BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13129110 WD repeat domain 77 [Homo sapiens] (342 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13129110 WD repeat domain 77 [Homo sapiens] 703 0.0 gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens] 65 9e-11 gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens] 65 9e-11 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 64 1e-10 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 64 1e-10 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 64 1e-10 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 61 2e-09 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 61 2e-09 gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 59 6e-09 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 58 1e-08 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 56 4e-08 gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 54 2e-07 gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 54 2e-07 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 54 2e-07 gi|16554629 WD repeat domain 5 [Homo sapiens] 54 3e-07 gi|16554627 WD repeat domain 5 [Homo sapiens] 54 3e-07 gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 53 5e-07 gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 53 5e-07 gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 53 5e-07 gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens] 53 5e-07 gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens] 53 5e-07 gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens] 53 5e-07 gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens] 53 5e-07 gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens] 53 5e-07 gi|19913369 transducin beta-like 3 [Homo sapiens] 52 6e-07 gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 52 1e-06 gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 50 2e-06 gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s... 50 3e-06 gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 50 3e-06 gi|89886480 zinedin isoform 2 [Homo sapiens] 50 4e-06 >gi|13129110 WD repeat domain 77 [Homo sapiens] Length = 342 Score = 703 bits (1814), Expect = 0.0 Identities = 342/342 (100%), Positives = 342/342 (100%) Query: 1 MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 60 MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL Sbjct: 1 MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 60 Query: 61 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC Sbjct: 61 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD Sbjct: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV Sbjct: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV Sbjct: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 Query: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE Sbjct: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342 >gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens] Length = 367 Score = 65.1 bits (157), Expect = 9e-11 Identities = 52/176 (29%), Positives = 83/176 (47%), Gaps = 8/176 (4%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D VS V+ L+S VSG KD + ++ V+ ++ H ++T VA P K S F Sbjct: 61 HMDTVSVVAALNSDL-CVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP-KSSQF 118 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 S S D +++WD Q C + T LA P S++ G + T+ L D Sbjct: 119 FSASRDRMVMMWDLHGSSQPRQQLC-GHAMVVTGLAVSPDSSQLCT-GSRDNTLLLWDVV 176 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS---SLSELFRSQAH 296 + V ++V VT L + P P++ SED +L + DS ++ +F ++ H Sbjct: 177 TGQSVERASVSRNVVTHLCWVPRE-PYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 231 >gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens] Length = 366 Score = 65.1 bits (157), Expect = 9e-11 Identities = 52/176 (29%), Positives = 83/176 (47%), Gaps = 8/176 (4%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D VS V+ L+S VSG KD + ++ V+ ++ H ++T VA P K S F Sbjct: 60 HMDTVSVVAALNSDL-CVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP-KSSQF 117 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 S S D +++WD Q C + T LA P S++ G + T+ L D Sbjct: 118 FSASRDRMVMMWDLHGSSQPRQQLC-GHAMVVTGLAVSPDSSQLCT-GSRDNTLLLWDVV 175 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS---SLSELFRSQAH 296 + V ++V VT L + P P++ SED +L + DS ++ +F ++ H Sbjct: 176 TGQSVERASVSRNVVTHLCWVPRE-PYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 230 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 64.3 bits (155), Expect = 1e-10 Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 5/161 (3%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V +V S G V+ S D +KVW +Q L S H V C SP + Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGRLI 122 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 +S S+D + LWD + + C G++ T + +HP + + G +N TV + D + Sbjct: 123 VSASDDKTVKLWD-KSSRECVHSYCEHGGFV-TYVDFHPSGTCIAAAGMDN-TVKVWDVR 179 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 + + +HS V GL F P S +L + S D +L +LD Sbjct: 180 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 219 Score = 52.4 bits (124), Expect = 6e-07 Identities = 51/192 (26%), Positives = 79/192 (41%), Gaps = 6/192 (3%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D V+ V+ SG SGS+D +++W + + +RAH A V V S F Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS-F 80 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 ++ S+D + +W T K + A + V ++ TV L D Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINW---VRCAKFSPDGRLIVSASDDKTVKLWDKS 137 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRD 302 S CV S H VT + F P S +A+ D ++ V D L + Q H V Sbjct: 138 SRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196 Query: 303 ATWSPLNHSLLT 314 ++ P + L+T Sbjct: 197 LSFHPSGNYLIT 208 Score = 49.3 bits (116), Expect = 5e-06 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R I+ ASD V+LW+ E V +C EH V+ V SGT + D +KV Sbjct: 120 RLIVSASDDKTVKLWDKSSREC--VHSYC--EHGGFVTYVDFHPSGTCIAAAGMDNTVKV 175 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 WD+ +L Y+ H+A V ++ P + ++ S D+ + + D Sbjct: 176 WDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 219 Score = 39.7 bits (91), Expect = 0.004 Identities = 42/178 (23%), Positives = 65/178 (36%), Gaps = 7/178 (3%) Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 D C+ VW + Q + H VTCV SP + S S D + +W P + Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLLASGSRDKTVRIW---VPNVKGE 57 Query: 206 IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 265 + FV ++ TV + T + S + H V FSP Sbjct: 58 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117 Query: 266 HSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRDATWSPLNHSLLTTVGWDHQV 322 + S S+D ++ + D S E S H FV + P + + + G D+ V Sbjct: 118 DG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTV 173 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 64.3 bits (155), Expect = 1e-10 Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 5/161 (3%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V +V S G V+ S D +KVW +Q L S H V C SP + Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD-GRLI 160 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 +S S+D + LWD + + C G++ T + +HP + + G +N TV + D + Sbjct: 161 VSASDDKTVKLWD-KSSRECVHSYCEHGGFV-TYVDFHPSGTCIAAAGMDN-TVKVWDVR 217 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 + + +HS V GL F P S +L + S D +L +LD Sbjct: 218 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257 Score = 50.8 bits (120), Expect = 2e-06 Identities = 50/200 (25%), Positives = 75/200 (37%), Gaps = 7/200 (3%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D V+ V + Q SGS D C+ VW + Q + H VTCV SP + Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLL 76 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 S S D + +W P + + FV ++ TV + T Sbjct: 77 ASGSRDKTVRIW---VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRD 302 + S + H V FSP + S S+D ++ + D S E S H FV Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192 Query: 303 ATWSPLNHSLLTTVGWDHQV 322 + P + + + G D+ V Sbjct: 193 VDFHP-SGTCIAAAGMDNTV 211 Score = 49.3 bits (116), Expect = 5e-06 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R I+ ASD V+LW+ E V +C EH V+ V SGT + D +KV Sbjct: 158 RLIVSASDDKTVKLWDKSSREC--VHSYC--EHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 WD+ +L Y+ H+A V ++ P + ++ S D+ + + D Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 64.3 bits (155), Expect = 1e-10 Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 5/161 (3%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V +V S G V+ S D +KVW +Q L S H V C SP + Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD-GRLI 160 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 +S S+D + LWD + + C G++ T + +HP + + G +N TV + D + Sbjct: 161 VSASDDKTVKLWD-KSSRECVHSYCEHGGFV-TYVDFHPSGTCIAAAGMDN-TVKVWDVR 217 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 + + +HS V GL F P S +L + S D +L +LD Sbjct: 218 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257 Score = 50.8 bits (120), Expect = 2e-06 Identities = 50/200 (25%), Positives = 75/200 (37%), Gaps = 7/200 (3%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D V+ V + Q SGS D C+ VW + Q + H VTCV SP + Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLL 76 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 S S D + +W P + + FV ++ TV + T Sbjct: 77 ASGSRDKTVRIW---VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRD 302 + S + H V FSP + S S+D ++ + D S E S H FV Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192 Query: 303 ATWSPLNHSLLTTVGWDHQV 322 + P + + + G D+ V Sbjct: 193 VDFHP-SGTCIAAAGMDNTV 211 Score = 49.3 bits (116), Expect = 5e-06 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R I+ ASD V+LW+ E V +C EH V+ V SGT + D +KV Sbjct: 158 RLIVSASDDKTVKLWDKSSREC--VHSYC--EHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 WD+ +L Y+ H+A V ++ P + ++ S D+ + + D Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 60.8 bits (146), Expect = 2e-09 Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 34/232 (14%) Query: 93 GILVASDSG--AVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 G L+AS S ++LW+ E + + HD VS+V+++ +G VS S+D IK Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTM----HGHDHNVSSVAIMPNGDHIVSASRDKTIK 217 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQIGCS 209 +W++ + ++ H V V P++D + SCS D + +W + +++ Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVATKECKAEL--R 273 Query: 210 APGYLPTSLAWHPQQS-------------------EVFVFGDENGTVSLVDTKSTSCVLS 250 ++ ++W P+ S + G + T+ + D + C+++ Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333 Query: 251 SAVHSQCVTGLVFSPHS-VPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300 H V G++F HS F+ S ++D +L V D ++ AH FV Sbjct: 334 LVGHDNWVRGVLF--HSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383 Score = 46.2 bits (108), Expect = 4e-05 Identities = 54/230 (23%), Positives = 85/230 (36%), Gaps = 18/230 (7%) Query: 97 ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 AS+ +++W+ + + K H D V +S SG S S D+ IK+WD Sbjct: 126 ASEDATIKVWDYETGDFERTLK----GHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181 Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR---CPKPASQIGCSAPGY 213 + + H V+ VA P+ D + +S S D I +W+ + C K + G+ Sbjct: 182 FECIRTMHGHDHNVSSVAIMPNGDHI-VSASRDKTIKMWEVQTGYCVK-------TFTGH 233 Query: 214 LPTSLAWHPQQSEVFVFGDENG-TVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 272 P Q + N TV + + C H V + ++P S + Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPES--SYS 291 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 S+SE S F RD L+T VG D+ V Sbjct: 292 SISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341 Score = 38.1 bits (87), Expect = 0.011 Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 12/171 (7%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR-- 198 VS S+D IKVWD + + H V ++ H + SCS D I LWD + Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGF 182 Query: 199 -CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQC 257 C + + +S+A P + V + T+ + + ++ CV + H + Sbjct: 183 ECIRT-----MHGHDHNVSSVAIMPNGDHI-VSASRDKTIKMWEVQTGYCVKTFTGHREW 236 Query: 258 VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSP 307 V +V +AS S D ++ V + E + H V +W+P Sbjct: 237 VR-MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP 286 Score = 32.7 bits (73), Expect = 0.48 Identities = 32/135 (23%), Positives = 60/135 (44%), Gaps = 12/135 (8%) Query: 67 APNEGFCSAGVQTEAGVADLTWVGERG--ILVASDSGAVELWELDENETLIVSKFCKYEH 124 AP + S +EA ++ G+ G +L S +++W++ L+ H Sbjct: 285 APESSYSSI---SEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL----VGH 337 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF- 183 D+ V V S G +S + D ++VWD + + + AH VT + HK + + Sbjct: 338 DNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVT--SLDFHKTAPYV 395 Query: 184 LSCSEDNRILLWDTR 198 ++ S D + +W+ R Sbjct: 396 VTGSVDQTVKVWECR 410 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 60.8 bits (146), Expect = 2e-09 Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 14/194 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G + + SD G V+LW++ + + +++ V V+ + Q +SG D I Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQT-----FQNTYQVLAVTFNDTSDQIISGGIDNDI 217 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 KVWDL Q + + R HA VT ++ S + S LS + DN + +WD R P + Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLS-SEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI 276 Query: 210 APGYLPT------SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 G + +W P S++ G + V + DT S + H+ + + F Sbjct: 277 FQGNVHNFEKNLLRCSWSPDGSKI-AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAF 335 Query: 264 SPHSVPFLASLSED 277 P P + S S D Sbjct: 336 HPDE-PIIISASSD 348 Score = 37.4 bits (85), Expect = 0.020 Identities = 41/194 (21%), Positives = 77/194 (39%), Gaps = 16/194 (8%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V + + G+ S S D + VWD + + H + V + + Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 + S+D + LWD R K A Q + Y ++ ++ ++ G +N + + D + Sbjct: 168 CTGSDDGTVKLWDIR-KKAAIQTFQNT--YQVLAVTFNDTSDQIISGGIDN-DIKVWDLR 223 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-------SSLSELFRSQAH 296 + H+ VTGL S +L S + D ++ V D ++F+ H Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSEG-SYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVH 282 Query: 297 ---RDFVRDATWSP 307 ++ +R +WSP Sbjct: 283 NFEKNLLR-CSWSP 295 >gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] Length = 323 Score = 58.9 bits (141), Expect = 6e-09 Identities = 59/249 (23%), Positives = 103/249 (41%), Gaps = 14/249 (5%) Query: 82 GVADLTWV--GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 G+ D+TW E ++ S G+++LW D + + K ++ S + G Q Sbjct: 69 GLFDVTWSENNEHVLITCSGDGSLQLW--DTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQ 126 Query: 140 -AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 VSGS D +K+WD L ++R H + + SPH F S S D + +WD + Sbjct: 127 LVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186 Query: 199 CPKPASQIGCSAPGYLPTSLA--WHPQQSEVFVFGDENGTVSLVDTKST-SCVLSSAVHS 255 A+ + P + L+ W + V G + ++ D ++ V H+ Sbjct: 187 ----AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHT 242 Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL--SELFRSQAHRDFVRDATWSPLNHSLL 313 + + FSP LAS S D ++ + S S L + H +F +S + + + Sbjct: 243 YAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQV 302 Query: 314 TTVGWDHQV 322 WD + Sbjct: 303 ADCSWDETI 311 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 58.2 bits (139), Expect = 1e-08 Identities = 49/184 (26%), Positives = 84/184 (45%), Gaps = 13/184 (7%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H + V +V+ +G SGS D ++ WDL+ + + + H V ++ SP + Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAWHP----QQSEVFVFGDENGTV 237 C ++ +ILLWD P Q+G + G+ T L+W P + ++G+V Sbjct: 173 SGC-KNGQILLWD---PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228 Query: 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAH 296 + DT + C H+Q VT L + + L S S+D ++ V + L R+ Q H Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDGL--LYSASQDRTIKVWRAHDGVLCRTLQGH 286 Query: 297 RDFV 300 +V Sbjct: 287 GHWV 290 Score = 41.2 bits (95), Expect = 0.001 Identities = 39/127 (30%), Positives = 56/127 (44%), Gaps = 7/127 (5%) Query: 141 VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 VSGS D + +W A+ + L+ H A + V SP + S S D I LWD R Sbjct: 345 VSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS-RIVASASFDKSIKLWDGRT 403 Query: 200 PKP-ASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 K AS G A Y +AW S + V G + T+ + D K+ + H+ V Sbjct: 404 GKYLASLRGHVAAVY---QIAWSAD-SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459 Query: 259 TGLVFSP 265 + +SP Sbjct: 460 YAVDWSP 466 Score = 39.7 bits (91), Expect = 0.004 Identities = 36/140 (25%), Positives = 56/140 (40%), Gaps = 10/140 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G ++ SD + LW E++ + H +++ V S S D I Sbjct: 340 GPERLVSGSDDFTLFLWSPAEDKKPLTRMT---GHQALINQVLFSPDSRIVASASFDKSI 396 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 K+WD L+S R H A V +A S + +S S D+ + +WD + K A + Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWDVKAQKLAMDL--- 452 Query: 210 APGYLPTSLA--WHPQQSEV 227 PG+ A W P V Sbjct: 453 -PGHADEVYAVDWSPDGQRV 471 Score = 35.4 bits (80), Expect = 0.074 Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 2/64 (3%) Query: 245 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDA 303 T C S HS+ V + FSP + +LAS S D ++ D S+ + F + HR +V Sbjct: 104 TRCTSSLEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSI 162 Query: 304 TWSP 307 +WSP Sbjct: 163 SWSP 166 Score = 35.0 bits (79), Expect = 0.097 Identities = 30/107 (28%), Positives = 45/107 (42%), Gaps = 6/107 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKY-----EHDDIVSTVSVLSSGTQAVSGSKDIC 148 +L + DS V D++ L + KY H V ++ + VSGS D Sbjct: 378 VLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDST 437 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 +KVWD+ Q + HA +V V SP V S +D + +W Sbjct: 438 LKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 483 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 56.2 bits (134), Expect = 4e-08 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 14/178 (7%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 E I+ S SG++ +W+L+ + L H + ++ G SGS+D IK Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILRTLM----GHKANICSLDFHPYGEFVASGSQDTNIK 130 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQIGCS 209 +WD+ ++ + YR H+ V C+ SP D +L S ++D+ + LWD K S+ Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSP--DGKWLASAADDHTVKLWDLTAGKMMSEF--- 185 Query: 210 APGYL-PTSLA-WHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 265 PG+ P ++ +HP + + G + T+ D + V V ++F+P Sbjct: 186 -PGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241 Score = 47.8 bits (112), Expect = 1e-05 Identities = 41/167 (24%), Positives = 76/167 (45%), Gaps = 9/167 (5%) Query: 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLS 185 ++ S V +SG +G D + +W + + + S H + V V + + + ++ Sbjct: 22 NVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT-PEELIVA 80 Query: 186 CSEDNRILLWDTRCPKPASQIGCSAPGYLPT--SLAWHPQQSEVFVFGDENGTVSLVDTK 243 S+ I +WD A++I + G+ SL +HP E G ++ + L D + Sbjct: 81 GSQSGSIRVWDLE----AAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIKLWDIR 135 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL 290 CV HSQ V L FSP +LAS ++D ++ + D + ++ Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDG-KWLASAADDHTVKLWDLTAGKM 181 Score = 42.0 bits (97), Expect = 8e-04 Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 5/107 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R + D V LW +++ ++ H V +V + + V+GS+ I+V Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLT----GHTSPVESVRLNTPEELIVAGSQSGSIRV 89 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 WDL +L + H A + + P+ + V S S+D I LWD R Sbjct: 90 WDLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIR 135 Score = 39.7 bits (91), Expect = 0.004 Identities = 38/160 (23%), Positives = 68/160 (42%), Gaps = 8/160 (5%) Query: 165 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYL-PTSLAWHPQ 223 AHA+ V+ + + + +D R+ LW P S G+ P Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI----MSLTGHTSPVESVRLNT 73 Query: 224 QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 E+ V G ++G++ + D ++ + + H + L F P+ F+AS S+D ++ + Sbjct: 74 PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIKLW 132 Query: 284 DSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D +FR + H VR +SP + L + DH V Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTV 171 Score = 39.3 bits (90), Expect = 0.005 Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 5/104 (4%) Query: 97 ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 A+D V+LW+L + ++S+F H V+ V + SGS D I+ WDL + Sbjct: 165 AADDHTVKLWDLTAGK--MMSEFPG--HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220 Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRC 199 V+S V V +P ++ C + R+ W+ RC Sbjct: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERC 264 >gi|5729852 guanine nucleotide-binding protein, beta-5 subunit isoform a [Homo sapiens] Length = 353 Score = 54.3 bits (129), Expect = 2e-07 Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 23/223 (10%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 D+NE + K H + +S S +S Q ++ S D +WD+ +L S+ H A Sbjct: 137 DKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGA 196 Query: 169 QVTCVAASPHK-DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 V C+ +P + + F+S D + ++WD R + S+ ++P + Sbjct: 197 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI--NSVRYYP-SGDA 253 Query: 228 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF------LASLSEDCSLA 281 F G ++ T L D ++ V A++S+ ++F SV F L + D ++ Sbjct: 254 FASGSDDATCRLYDLRADREV---AIYSK--ESIIFGASSVDFSLSGRLLFAGYNDYTIN 308 Query: 282 VLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320 V D S +S LF H + V SP + + + WDH Sbjct: 309 VWDVLKGSRVSILF---GHENRVSTLRVSP-DGTAFCSGSWDH 347 Score = 28.5 bits (62), Expect = 9.1 Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 + H++ VST+ V GT SGS D ++VW Sbjct: 322 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 >gi|20336270 guanine nucleotide-binding protein, beta-5 subunit isoform b [Homo sapiens] Length = 395 Score = 54.3 bits (129), Expect = 2e-07 Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 23/223 (10%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 D+NE + K H + +S S +S Q ++ S D +WD+ +L S+ H A Sbjct: 179 DKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGA 238 Query: 169 QVTCVAASPHK-DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 V C+ +P + + F+S D + ++WD R + S+ ++P + Sbjct: 239 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI--NSVRYYP-SGDA 295 Query: 228 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF------LASLSEDCSLA 281 F G ++ T L D ++ V A++S+ ++F SV F L + D ++ Sbjct: 296 FASGSDDATCRLYDLRADREV---AIYSK--ESIIFGASSVDFSLSGRLLFAGYNDYTIN 350 Query: 282 VLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320 V D S +S LF H + V SP + + + WDH Sbjct: 351 VWDVLKGSRVSILF---GHENRVSTLRVSP-DGTAFCSGSWDH 389 Score = 28.5 bits (62), Expect = 9.1 Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 + H++ VST+ V GT SGS D ++VW Sbjct: 364 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 53.9 bits (128), Expect = 2e-07 Identities = 59/222 (26%), Positives = 90/222 (40%), Gaps = 11/222 (4%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V + L+ + +S S+D+ I+ WDL Y+ HA V + SP+ F Sbjct: 341 HCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY-SLYF 399 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAWHPQQSEVFVFGDENGTVSLVD 241 S S D LW P G+L + +HP S G + TV L Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYA----GHLADVDCVKFHP-NSNYLATGSTDKTVRLWS 454 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300 + + V H V L FSP+ +LAS ED L + D + L++ + H D + Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNG-KYLASAGEDQRLKLWDLASGTLYKELRGHTDNI 513 Query: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342 T+SP + L+ + D+ V + AP S +E Sbjct: 514 TSLTFSP-DSGLIASASMDNSVRVWDIRNTYCSAPADGSSSE 554 Score = 46.2 bits (108), Expect = 4e-05 Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 13/194 (6%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDI-VSTVSVLSSGTQAVSGSKDICIKV 151 G+L S+ ++ W+L ++ + Y D+ +S S+ + SGS D ++ Sbjct: 356 GLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFA-----SGSHDRTARL 410 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-GCSA 210 W + L Y H A V CV P+ + + S D + LW + G Sbjct: 411 WSFDRTYPLRIYAGHLADVDCVKFHPN-SNYLATGSTDKTVRLWSAQQGNSVRLFTGHRG 469 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF 270 P SLA+ P + E+ + L D S + H+ +T L FSP S Sbjct: 470 P---VLSLAFSP-NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS-GL 524 Query: 271 LASLSEDCSLAVLD 284 +AS S D S+ V D Sbjct: 525 IASASMDNSVRVWD 538 Score = 44.3 bits (103), Expect = 2e-04 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 8/113 (7%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW + ++ + H V +++ +G S +D +K+WD Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFT----GHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR---CPKPA 203 LA + R H +T + SP + S S DN + +WD R C PA Sbjct: 497 LASGTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDIRNTYCSAPA 548 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 53.5 bits (127), Expect = 3e-07 Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 19/234 (8%) Query: 82 GVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 G++D+ W + +LV ASD +++W++ + L K H + V + Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSNLI 144 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--- 197 VSGS D +++WD+ L + AH+ V+ V + S+ +S S D +WDT Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASG 203 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ- 256 +C K + I P P S + + + T+ L D C+ + H Sbjct: 204 QCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 Query: 257 --CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 307 C+ FS ++ S SED + + + E+ + Q H D V P Sbjct: 259 KYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 Score = 42.7 bits (99), Expect = 5e-04 Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 2/107 (1%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 IL A+ ++LW+ + + L K E I + SV + G VSGS+D + +W+ Sbjct: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWN 287 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE-DNRILLWDTRC 199 L + ++ + H V A P ++ + + E D I LW + C Sbjct: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 53.5 bits (127), Expect = 3e-07 Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 19/234 (8%) Query: 82 GVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 G++D+ W + +LV ASD +++W++ + L K H + V + Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSNLI 144 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--- 197 VSGS D +++WD+ L + AH+ V+ V + S+ +S S D +WDT Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASG 203 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ- 256 +C K + I P P S + + + T+ L D C+ + H Sbjct: 204 QCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 Query: 257 --CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 307 C+ FS ++ S SED + + + E+ + Q H D V P Sbjct: 259 KYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 Score = 42.7 bits (99), Expect = 5e-04 Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 2/107 (1%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 IL A+ ++LW+ + + L K E I + SV + G VSGS+D + +W+ Sbjct: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWN 287 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE-DNRILLWDTRC 199 L + ++ + H V A P ++ + + E D I LW + C Sbjct: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 >gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sapiens] Length = 390 Score = 52.8 bits (125), Expect = 5e-07 Identities = 43/169 (25%), Positives = 80/169 (47%), Gaps = 10/169 (5%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGYLPT--SL 218 R H + ++ +P+ LS S+D+ I LWD + PK + G+ + Sbjct: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275 +WH +F ++ + + DT+S + S H+ V L F+P+S LA+ S Sbjct: 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 258 Query: 276 EDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D ++A+ D + +L ++H+D + WSP N ++L + G D ++ Sbjct: 259 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307 Score = 51.2 bits (121), Expect = 1e-06 Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 28/206 (13%) Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D I +WD++ +VV + + H A V V+ +S+F S ++D +++ Sbjct: 159 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 218 Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 219 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 276 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 277 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 336 Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320 H + D +W+P ++ +V D+ Sbjct: 337 GHTAKISDFSWNPNEPWVICSVSEDN 362 Score = 43.1 bits (100), Expect = 4e-04 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 24/178 (13%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L +LSG + S LW D A P EG G V D Sbjct: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 197 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140 ++W + E +D + +W+ N T S + D + V+ LS + Sbjct: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS----HSVDAHTAEVNCLSFNPYSEFI 253 Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +GS D + +WDL ++ L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 254 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311 Score = 39.3 bits (90), Expect = 0.005 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149 +L ASD + LW++ + ++ +K H +V VS L + S + D + Sbjct: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217 Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +WD S AH A+V C++ +P+ + + + S D + LWD R Sbjct: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269 Score = 30.0 bits (66), Expect = 3.1 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 254 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 311 Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 312 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367 >gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sapiens] Length = 424 Score = 52.8 bits (125), Expect = 5e-07 Identities = 43/169 (25%), Positives = 80/169 (47%), Gaps = 10/169 (5%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGYLPT--SL 218 R H + ++ +P+ LS S+D+ I LWD + PK + G+ + Sbjct: 173 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 232 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275 +WH +F ++ + + DT+S + S H+ V L F+P+S LA+ S Sbjct: 233 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 292 Query: 276 EDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D ++A+ D + +L ++H+D + WSP N ++L + G D ++ Sbjct: 293 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 341 Score = 51.2 bits (121), Expect = 1e-06 Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 28/206 (13%) Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D I +WD++ +VV + + H A V V+ +S+F S ++D +++ Sbjct: 193 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 252 Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 253 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 310 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 311 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 370 Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320 H + D +W+P ++ +V D+ Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDN 396 Score = 43.1 bits (100), Expect = 4e-04 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 24/178 (13%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L +LSG + S LW D A P EG G V D Sbjct: 175 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 231 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140 ++W + E +D + +W+ N T S + D + V+ LS + Sbjct: 232 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS----HSVDAHTAEVNCLSFNPYSEFI 287 Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +GS D + +WDL ++ L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 288 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 345 Score = 39.3 bits (90), Expect = 0.005 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149 +L ASD + LW++ + ++ +K H +V VS L + S + D + Sbjct: 192 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 251 Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +WD S AH A+V C++ +P+ + + + S D + LWD R Sbjct: 252 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303 Score = 30.0 bits (66), Expect = 3.1 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 288 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 345 Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 346 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 401 >gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapiens] Length = 425 Score = 52.8 bits (125), Expect = 5e-07 Identities = 43/169 (25%), Positives = 80/169 (47%), Gaps = 10/169 (5%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGYLPT--SL 218 R H + ++ +P+ LS S+D+ I LWD + PK + G+ + Sbjct: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275 +WH +F ++ + + DT+S + S H+ V L F+P+S LA+ S Sbjct: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 Query: 276 EDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D ++A+ D + +L ++H+D + WSP N ++L + G D ++ Sbjct: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 Score = 51.2 bits (121), Expect = 1e-06 Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 28/206 (13%) Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D I +WD++ +VV + + H A V V+ +S+F S ++D +++ Sbjct: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253 Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 254 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 371 Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320 H + D +W+P ++ +V D+ Sbjct: 372 GHTAKISDFSWNPNEPWVICSVSEDN 397 Score = 43.1 bits (100), Expect = 4e-04 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 24/178 (13%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L +LSG + S LW D A P EG G V D Sbjct: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 232 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140 ++W + E +D + +W+ N T S + D + V+ LS + Sbjct: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS----HSVDAHTAEVNCLSFNPYSEFI 288 Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +GS D + +WDL ++ L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 Score = 39.3 bits (90), Expect = 0.005 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149 +L ASD + LW++ + ++ +K H +V VS L + S + D + Sbjct: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +WD S AH A+V C++ +P+ + + + S D + LWD R Sbjct: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 Score = 30.0 bits (66), Expect = 3.1 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 289 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 346 Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 >gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens] Length = 1205 Score = 52.8 bits (125), Expect = 5e-07 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 93 GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 G+L+A ++G + L++ + ++ +++++ K+ V++ + A SG+ + Sbjct: 87 GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145 Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 I +WDL A + + ++C+A + + S S R +WD R +P Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260 ++ + + LAWHP + V E+ + ++ D + S L H++ + Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319 + +S L S +D + + + E L+ + + D W P N ++L+ +D Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325 Query: 320 HQV 322 ++ Sbjct: 326 GRI 328 >gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens] Length = 1220 Score = 52.8 bits (125), Expect = 5e-07 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 93 GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 G+L+A ++G + L++ + ++ +++++ K+ V++ + A SG+ + Sbjct: 87 GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145 Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 I +WDL A + + ++C+A + + S S R +WD R +P Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260 ++ + + LAWHP + V E+ + ++ D + S L H++ + Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319 + +S L S +D + + + E L+ + + D W P N ++L+ +D Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325 Query: 320 HQV 322 ++ Sbjct: 326 GRI 328 >gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens] Length = 1106 Score = 52.8 bits (125), Expect = 5e-07 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 93 GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 G+L+A ++G + L++ + ++ +++++ K+ V++ + A SG+ + Sbjct: 87 GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145 Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 I +WDL A + + ++C+A + + S S R +WD R +P Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260 ++ + + LAWHP + V E+ + ++ D + S L H++ + Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319 + +S L S +D + + + E L+ + + D W P N ++L+ +D Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325 Query: 320 HQV 322 ++ Sbjct: 326 GRI 328 >gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens] Length = 1181 Score = 52.8 bits (125), Expect = 5e-07 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 93 GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 G+L+A ++G + L++ + ++ +++++ K+ V++ + A SG+ + Sbjct: 87 GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145 Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 I +WDL A + + ++C+A + + S S R +WD R +P Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260 ++ + + LAWHP + V E+ + ++ D + S L H++ + Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319 + +S L S +D + + + E L+ + + D W P N ++L+ +D Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325 Query: 320 HQV 322 ++ Sbjct: 326 GRI 328 >gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens] Length = 1220 Score = 52.8 bits (125), Expect = 5e-07 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 93 GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 G+L+A ++G + L++ + ++ +++++ K+ V++ + A SG+ + Sbjct: 87 GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145 Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 I +WDL A + + ++C+A + + S S R +WD R +P Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260 ++ + + LAWHP + V E+ + ++ D + S L H++ + Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319 + +S L S +D + + + E L+ + + D W P N ++L+ +D Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325 Query: 320 HQV 322 ++ Sbjct: 326 GRI 328 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 52.4 bits (124), Expect = 6e-07 Identities = 54/222 (24%), Positives = 89/222 (40%), Gaps = 21/222 (9%) Query: 91 ERGILVASDSGAVELWEL-----------DENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 E ++ S V+LW L D L+ ++ + HD +++V++ + Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKL 493 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW---D 196 +GS+D K+W L Q +L + H + CV SP D V + S D I LW D Sbjct: 494 LATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSP-MDQVLATASADGTIKLWALQD 552 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ 256 C K S +A+ + +++ G + G V L K+ CV + H Sbjct: 553 FSCLKTFEGHDASV-----LKVAFVSRGTQLLSSGSD-GLVKLWTIKNNECVRTLDAHED 606 Query: 257 CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRD 298 V GL S L S+ + D + +E QA ++ Sbjct: 607 KVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQE 648 Score = 43.5 bits (101), Expect = 3e-04 Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 10/118 (8%) Query: 83 VADLTWVG--ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 V D+ ++G + ++VAS+S ++++EL + I+ + H DIV + V G Sbjct: 337 VLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL-----HGHTDIVLALDVFRKGWLF 391 Query: 141 VSGSKDICIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 S +KD +++W + Q + ++ H V V S K+S ++ S+D + LW Sbjct: 392 ASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449 Score = 37.7 bits (86), Expect = 0.015 Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 34/131 (25%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC-- 199 S + D I+VW L + L+ AH + VT +A S ++ LS D ++WD + Sbjct: 170 SSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM-LSSGRDKICIIWDLQSCQ 228 Query: 200 ------------------PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 +P SQ+G +PG F+ + GT+ + + Sbjct: 229 ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGL-------------YFLTAGDQGTLRVWE 275 Query: 242 TKSTSCVLSSA 252 S CV + A Sbjct: 276 AASGQCVYTQA 286 >gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] Length = 425 Score = 51.6 bits (122), Expect = 1e-06 Identities = 40/149 (26%), Positives = 72/149 (48%), Gaps = 10/149 (6%) Query: 184 LSCSEDNRILLWDTRC-PKPASQIGCSA----PGYLPTSLAWHPQQSEVFVFGDENGTVS 238 LS S+D+ + LWD PK + A + +AWH +F ++ + Sbjct: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252 Query: 239 LVDTKSTSCVLSSAV---HSQCVTGLVFSPHSVPFLASLSEDCSLAVLD--SSLSELFRS 293 + DT+S + S + H+ V L F+P+S LA+ S D ++A+ D + +L Sbjct: 253 IWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF 312 Query: 294 QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 ++H+D + WSP N ++L + G D ++ Sbjct: 313 ESHKDEIFQVHWSPHNETILASSGTDRRL 341 Score = 48.5 bits (114), Expect = 8e-06 Identities = 50/206 (24%), Positives = 90/206 (43%), Gaps = 28/206 (13%) Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D + +WD+ ++V + + H+A V VA +S+F S ++D +++ Sbjct: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252 Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 253 IWDTRSNTTSKPSHLVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 310 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 + H + + +SPH+ LAS D L V D S + E LF Sbjct: 311 TFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHG 370 Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320 H + D +W+P ++ +V D+ Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDN 396 Score = 41.6 bits (96), Expect = 0.001 Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 24/178 (13%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L S+LSG + S LW D A P EG G V D Sbjct: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLW---DINAGPKEGKIVDAKAIFTGHSAVVED 231 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140 + W + E +D + +W+ N T S D + V+ LS + Sbjct: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLV----DAHTAEVNCLSFNPYSEFI 287 Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +GS D + +WDL ++ L ++ +H ++ V SPH +++ S D R+ +WD Sbjct: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345 Score = 39.3 bits (90), Expect = 0.005 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149 +L ASD V LW+++ + ++ +K H +V V+ L + S + D + Sbjct: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251 Query: 150 KVWDLAQQVVLSSYR---AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +WD AH A+V C++ +P+ + + + S D + LWD R Sbjct: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303 Score = 29.6 bits (65), Expect = 4.1 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 288 LATGSADKTVALWDL-RNLKLKLHTFESHK-DEIFQVHWSPHNETILASSGTDRRLNVWD 345 Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 346 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401 >gi|4758032 coatomer protein complex, subunit beta 2 (beta prime) [Homo sapiens] Length = 906 Score = 50.4 bits (119), Expect = 2e-06 Identities = 47/210 (22%), Positives = 93/210 (44%), Gaps = 30/210 (14%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS-YRAHAAQVTCVAASPHKDSV 182 H D + ++V + ++ S D+ IK+WD ++ S + H V + +P ++ Sbjct: 98 HSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQ 157 Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ-----------QSEVFVFG 231 F S S D I +W Q+G S+P + +L H + + G Sbjct: 158 FASASLDRTIKVW---------QLGSSSPNF---TLEGHEKGVNCIDYYSGGDKPYLISG 205 Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 ++ V + D ++ +CV + H+Q V+ F P +P + + SED ++ + SS + Sbjct: 206 ADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIWHSS---TY 261 Query: 292 RSQAHRDFVRDATW--SPLNHSLLTTVGWD 319 R ++ ++ + W + L S +G+D Sbjct: 262 RLESTLNYGMERVWCVASLRGSNNVALGYD 291 Score = 43.5 bits (101), Expect = 3e-04 Identities = 24/101 (23%), Positives = 47/101 (46%), Gaps = 7/101 (6%) Query: 97 ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--VSGSKDICIKVWDL 154 AS +++W+L + F H+ V+ + S G + +SG+ D +K+WD Sbjct: 161 ASLDRTIKVWQLGSSSP----NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY 216 Query: 155 AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 + + + HA V+C + P + ++ SED + +W Sbjct: 217 QNKTCVQTLEGHAQNVSCASFHPEL-PIIITGSEDGTVRIW 256 Score = 41.6 bits (96), Expect = 0.001 Identities = 35/147 (23%), Positives = 62/147 (42%), Gaps = 6/147 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 IL +SD ++LW+ D+ + S+ + ++ V Q S S D IKVW Sbjct: 114 ILTSSDDMLIKLWDWDKKWSC--SQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL-LWDTRCPKPASQIGCSAPG 212 L + H V C+ D +L D+R++ +WD + + A Sbjct: 172 LGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQN 231 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSL 239 + ++HP + + + G E+GTV + Sbjct: 232 V--SCASFHP-ELPIIITGSEDGTVRI 255 Score = 41.2 bits (95), Expect = 0.001 Identities = 44/196 (22%), Positives = 90/196 (45%), Gaps = 9/196 (4%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDI-VSTVSVLSSGTQAVSGSKDICI 149 E +L + +G+V +W E +TL+ + +E D+ V ++ V+G+ D+ I Sbjct: 27 EPWMLASLYNGSVCVWN-HETQTLVKT----FEVCDLPVRAAKFVARKNWVVTGADDMQI 81 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 +V++ + + AH+ + C+A P + + L+ S+D I LWD SQ+ Sbjct: 82 RVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFI-LTSSDDMLIKLWDWDKKWSCSQVFEG 140 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL-VFSPHSV 268 Y+ + +P+ + F + T+ + S+S + H + V + +S Sbjct: 141 HTHYV-MQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDK 199 Query: 269 PFLASLSEDCSLAVLD 284 P+L S ++D + + D Sbjct: 200 PYLISGADDRLVKIWD 215 Score = 28.5 bits (62), Expect = 9.1 Identities = 29/129 (22%), Positives = 59/129 (45%), Gaps = 7/129 (5%) Query: 66 AAPNEGFCSAGVQTEAGVADLTWVGERGILVA-SDSGAVELWELDENETLIVSKFCKYEH 124 ++PN F G + D G++ L++ +D V++W+ +N+T + + H Sbjct: 175 SSPN--FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY-QNKTCVQTL---EGH 228 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 VS S ++GS+D +++W + + S+ +V CVA+ ++V L Sbjct: 229 AQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVAL 288 Query: 185 SCSEDNRIL 193 E + I+ Sbjct: 289 GYDEGSIIV 297 >gi|4507703 tumor suppressing subtransferable candidate 1 [Homo sapiens] Length = 387 Score = 50.1 bits (118), Expect = 3e-06 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 13/235 (5%) Query: 102 AVELWELDENET---LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158 A E+W + + ++ + + + +++ +V + SGS + AQ + Sbjct: 64 AGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTL 123 Query: 159 VLSSYRAHAAQ--VTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP----G 212 L + + A + CV P D + DN ILLWD + + + SA G Sbjct: 124 ELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183 Query: 213 YLP-TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQCVTGLVFSPHSVPF 270 L TS W P + V + T+ DT+S S + H Q V L F+P+ + Sbjct: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYY 243 Query: 271 LASLSEDCSLAVLDS-SLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 LAS +DC + D+ +++E ++ + H +V + ++ + L+ T D +V+ Sbjct: 244 LASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVI 298 Score = 35.0 bits (79), Expect = 0.097 Identities = 51/267 (19%), Positives = 103/267 (38%), Gaps = 20/267 (7%) Query: 70 EGFCSAGVQTEAGVADLTW--VGERGILVASDSGAVELWELDENET-LIVSKFCKYEHDD 126 E C +A + W +G+ +++ + LW+L E+ + +++ E Sbjct: 124 ELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183 Query: 127 IVSTVSVLSS---GTQAVSGSKDICIKVWDL-AQQVVLSSYRAHAAQVTCVAASPHKDSV 182 + S S V+ + D ++ WD + + AH V + +P+K Sbjct: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYY 243 Query: 183 FLSCSEDNRILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 SC +D ++ WDTR +P + + ++ ++ ++ + G + V L + Sbjct: 244 LASCGDDCKVKFWDTRNVTEPVKTL--EEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSN 301 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVR 301 S S S+ LV SE+ S L ++ + + H D V Sbjct: 302 MVSIS--------SEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATY--EEHEDSVY 351 Query: 302 DATWSPLNHSLLTTVGWDHQVVHHVVP 328 WS + L ++ +D ++V + VP Sbjct: 352 AVDWSSADPWLFASLSYDGRLVINRVP 378 >gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] Length = 1336 Score = 50.1 bits (118), Expect = 3e-06 Identities = 35/146 (23%), Positives = 65/146 (44%), Gaps = 9/146 (6%) Query: 81 AGVADLTWVGERGILVASDSGA---VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSG 137 A V + W +G++V+ + ++ W+ ++L + H + V V + +G Sbjct: 245 ADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATL----HAHKNTVMEVKLNLNG 300 Query: 138 TQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 ++ S+D K++D+ + L +R H + T VA P + +F S D +L W Sbjct: 301 NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHP 222 K + + G + SLAWHP Sbjct: 361 VGVEKEVGGMEMAHEGMI-WSLAWHP 385 Score = 43.1 bits (100), Expect = 4e-04 Identities = 58/250 (23%), Positives = 98/250 (39%), Gaps = 19/250 (7%) Query: 88 WVGE-RGILVASDSGAVELWE-LDEN-ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 W E R ++ + SG LW L N ET++ + HD V ++ + ++ Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQA------HDSPVRAMTWSHNDMWMLTAD 180 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPA 203 +K W V ++AH + + SP D+ F +CS+D + +WD RC + Sbjct: 181 HGGYVKYWQSNMNNV-KMFQAHKEAIREASFSP-TDNKFATCSDDGTVRIWDFLRCHEER 238 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFG--DENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261 G A + WHP + V V G D + D K+ + + H V + Sbjct: 239 ILRGHGAD---VKCVDWHPTKGLV-VSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEV 294 Query: 262 VFSPHSVPFL-ASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320 + + L AS C L + + EL + H+ W P++ L + G D Sbjct: 295 KLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDG 354 Query: 321 QVVHHVVPTE 330 ++ V E Sbjct: 355 SLLFWHVGVE 364 Score = 40.4 bits (93), Expect = 0.002 Identities = 58/277 (20%), Positives = 99/277 (35%), Gaps = 26/277 (9%) Query: 42 LLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWV-GERGILVASDS 100 L+ GASS W G + F+ A ++ V +TW + +L A Sbjct: 134 LVTGASSGEFTLWNGLTFNFETILQAH-----------DSPVRAMTWSHNDMWMLTADHG 182 Query: 101 GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL 160 G V+ W+ + N + H + + S + + + S D +++WD + Sbjct: 183 GYVKYWQSNMNNVKMFQA-----HKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEE 237 Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSCSEDNR--ILLWDTRCPKPASQIGCSAPGYLPTSL 218 R H A V CV P K V +S S+D++ I WD + + + + + L Sbjct: 238 RILRGHGADVKCVDWHPTKGLV-VSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKL 296 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQCVTGLVFSPHSVPFLASLSED 277 + + + L D ++ L H + T + + P AS D Sbjct: 297 NLN---GNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSD 353 Query: 278 CSLAVLDSSLSELF--RSQAHRDFVRDATWSPLNHSL 312 SL + + AH + W PL H L Sbjct: 354 GSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHIL 390 >gi|89886480 zinedin isoform 2 [Homo sapiens] Length = 760 Score = 49.7 bits (117), Expect = 4e-06 Identities = 57/236 (24%), Positives = 89/236 (37%), Gaps = 29/236 (12%) Query: 91 ERGILVASDSGAVELWELDE------NETLIVSKFCKYE-HDDIVSTVSVLSSGTQAVSG 143 + +L AS+ G ++LW L + N L V + H V V++ S+ SG Sbjct: 457 QSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 516 Query: 144 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF-----------LSCSEDNRI 192 D CI W + + + Y + V H D+V+ SCS D + Sbjct: 517 GADACIHSWKIPD-LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 575 Query: 193 LLWDTRCPKPASQIGCSAPGY----LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV 248 +WD PA C+ P +PTS+A+ + V +G L D + S + Sbjct: 576 RIWDPSSSSPACL--CTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSAL 633 Query: 249 L---SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ-AHRDFV 300 L S V S + P + +D + LD+ + S AH D V Sbjct: 634 LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV 689 Score = 30.4 bits (67), Expect = 2.4 Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 4/60 (6%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ----VTCVAASPHK 179 H D V+ ++V +G +SGS D +++W L + + AH + + VA P K Sbjct: 685 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 744 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.130 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,251,837 Number of Sequences: 37866 Number of extensions: 698509 Number of successful extensions: 3446 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 156 Number of HSP's successfully gapped in prelim test: 142 Number of HSP's that attempted gapping in prelim test: 2492 Number of HSP's gapped (non-prelim): 829 length of query: 342 length of database: 18,247,518 effective HSP length: 103 effective length of query: 239 effective length of database: 14,347,320 effective search space: 3429009480 effective search space used: 3429009480 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.