Search of human proteins with 13129110

Search of human proteins with 13129110

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13129110 WD repeat domain 77 [Homo sapiens]
         (342 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13129110 WD repeat domain 77 [Homo sapiens]                        703   0.0  
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]               65   9e-11
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]               65   9e-11
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             64   1e-10
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             64   1e-10
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             64   1e-10
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    61   2e-09
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    61   2e-09
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              59   6e-09
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            58   1e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     56   4e-08
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    54   2e-07
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    54   2e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     54   2e-07
gi|16554629 WD repeat domain 5 [Homo sapiens]                          54   3e-07
gi|16554627 WD repeat domain 5 [Homo sapiens]                          54   3e-07
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    53   5e-07
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    53   5e-07
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    53   5e-07
gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens]                  53   5e-07
gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens]                  53   5e-07
gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens]                  53   5e-07
gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens]                   53   5e-07
gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens]                   53   5e-07
gi|19913369 transducin beta-like 3 [Homo sapiens]                      52   6e-07
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             52   1e-06
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)...    50   2e-06
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s...    50   3e-06
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               50   3e-06
gi|89886480 zinedin isoform 2 [Homo sapiens]                           50   4e-06

>gi|13129110 WD repeat domain 77 [Homo sapiens]
          Length = 342

 Score =  703 bits (1814), Expect = 0.0
 Identities = 342/342 (100%), Positives = 342/342 (100%)

Query: 1   MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 60
           MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL
Sbjct: 1   MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 60

Query: 61  FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120
           FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC
Sbjct: 61  FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120

Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180
           KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD
Sbjct: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180

Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240
           SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV
Sbjct: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240

Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300
           DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV
Sbjct: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300

Query: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342
           RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE
Sbjct: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342


>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
          Length = 367

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 52/176 (29%), Positives = 83/176 (47%), Gaps = 8/176 (4%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H D VS V+ L+S    VSG KD  +  ++     V+  ++ H  ++T VA  P K S F
Sbjct: 61  HMDTVSVVAALNSDL-CVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP-KSSQF 118

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
            S S D  +++WD        Q  C     + T LA  P  S++   G  + T+ L D  
Sbjct: 119 FSASRDRMVMMWDLHGSSQPRQQLC-GHAMVVTGLAVSPDSSQLCT-GSRDNTLLLWDVV 176

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS---SLSELFRSQAH 296
           +   V  ++V    VT L + P   P++   SED +L + DS    ++ +F ++ H
Sbjct: 177 TGQSVERASVSRNVVTHLCWVPRE-PYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 231


>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
          Length = 366

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 52/176 (29%), Positives = 83/176 (47%), Gaps = 8/176 (4%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H D VS V+ L+S    VSG KD  +  ++     V+  ++ H  ++T VA  P K S F
Sbjct: 60  HMDTVSVVAALNSDL-CVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP-KSSQF 117

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
            S S D  +++WD        Q  C     + T LA  P  S++   G  + T+ L D  
Sbjct: 118 FSASRDRMVMMWDLHGSSQPRQQLC-GHAMVVTGLAVSPDSSQLCT-GSRDNTLLLWDVV 175

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS---SLSELFRSQAH 296
           +   V  ++V    VT L + P   P++   SED +L + DS    ++ +F ++ H
Sbjct: 176 TGQSVERASVSRNVVTHLCWVPRE-PYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 230


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 5/161 (3%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H   V +V   S G   V+ S D  +KVW   +Q  L S   H   V C   SP    + 
Sbjct: 64  HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGRLI 122

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
           +S S+D  + LWD +  +      C   G++ T + +HP  + +   G +N TV + D +
Sbjct: 123 VSASDDKTVKLWD-KSSRECVHSYCEHGGFV-TYVDFHPSGTCIAAAGMDN-TVKVWDVR 179

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284
           +   +    +HS  V GL F P S  +L + S D +L +LD
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 219



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 51/192 (26%), Positives = 79/192 (41%), Gaps = 6/192 (3%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H D V+ V+   SG    SGS+D  +++W    +   + +RAH A V  V       S F
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS-F 80

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
           ++ S+D  + +W T   K    +            A       + V   ++ TV L D  
Sbjct: 81  VTASDDKTVKVWATHRQKFLFSLSQHINW---VRCAKFSPDGRLIVSASDDKTVKLWDKS 137

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRD 302
           S  CV S   H   VT + F P S   +A+   D ++ V D     L +  Q H   V  
Sbjct: 138 SRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196

Query: 303 ATWSPLNHSLLT 314
            ++ P  + L+T
Sbjct: 197 LSFHPSGNYLIT 208



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%)

Query: 92  RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151
           R I+ ASD   V+LW+    E   V  +C  EH   V+ V    SGT   +   D  +KV
Sbjct: 120 RLIVSASDDKTVKLWDKSSREC--VHSYC--EHGGFVTYVDFHPSGTCIAAAGMDNTVKV 175

Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
           WD+    +L  Y+ H+A V  ++  P   +  ++ S D+ + + D
Sbjct: 176 WDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 219



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 42/178 (23%), Positives = 65/178 (36%), Gaps = 7/178 (3%)

Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205
           D C+ VW +  Q     +  H   VTCV  SP    +  S S D  + +W    P    +
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLLASGSRDKTVRIW---VPNVKGE 57

Query: 206 IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 265
                               + FV   ++ TV +  T     + S + H   V    FSP
Sbjct: 58  STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117

Query: 266 HSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRDATWSPLNHSLLTTVGWDHQV 322
                + S S+D ++ + D S  E   S   H  FV    + P + + +   G D+ V
Sbjct: 118 DG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTV 173


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 5/161 (3%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H   V +V   S G   V+ S D  +KVW   +Q  L S   H   V C   SP    + 
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD-GRLI 160

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
           +S S+D  + LWD +  +      C   G++ T + +HP  + +   G +N TV + D +
Sbjct: 161 VSASDDKTVKLWD-KSSRECVHSYCEHGGFV-TYVDFHPSGTCIAAAGMDN-TVKVWDVR 217

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284
           +   +    +HS  V GL F P S  +L + S D +L +LD
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 50/200 (25%), Positives = 75/200 (37%), Gaps = 7/200 (3%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H D V+ V    +  Q  SGS D C+ VW +  Q     +  H   VTCV  SP    + 
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLL 76

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
            S S D  + +W    P    +                    + FV   ++ TV +  T 
Sbjct: 77  ASGSRDKTVRIW---VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRD 302
               + S + H   V    FSP     + S S+D ++ + D S  E   S   H  FV  
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192

Query: 303 ATWSPLNHSLLTTVGWDHQV 322
             + P + + +   G D+ V
Sbjct: 193 VDFHP-SGTCIAAAGMDNTV 211



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%)

Query: 92  RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151
           R I+ ASD   V+LW+    E   V  +C  EH   V+ V    SGT   +   D  +KV
Sbjct: 158 RLIVSASDDKTVKLWDKSSREC--VHSYC--EHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213

Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
           WD+    +L  Y+ H+A V  ++  P   +  ++ S D+ + + D
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 5/161 (3%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H   V +V   S G   V+ S D  +KVW   +Q  L S   H   V C   SP    + 
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD-GRLI 160

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
           +S S+D  + LWD +  +      C   G++ T + +HP  + +   G +N TV + D +
Sbjct: 161 VSASDDKTVKLWD-KSSRECVHSYCEHGGFV-TYVDFHPSGTCIAAAGMDN-TVKVWDVR 217

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284
           +   +    +HS  V GL F P S  +L + S D +L +LD
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 50/200 (25%), Positives = 75/200 (37%), Gaps = 7/200 (3%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H D V+ V    +  Q  SGS D C+ VW +  Q     +  H   VTCV  SP    + 
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLL 76

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
            S S D  + +W    P    +                    + FV   ++ TV +  T 
Sbjct: 77  ASGSRDKTVRIW---VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRD 302
               + S + H   V    FSP     + S S+D ++ + D S  E   S   H  FV  
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192

Query: 303 ATWSPLNHSLLTTVGWDHQV 322
             + P + + +   G D+ V
Sbjct: 193 VDFHP-SGTCIAAAGMDNTV 211



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 5/105 (4%)

Query: 92  RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151
           R I+ ASD   V+LW+    E   V  +C  EH   V+ V    SGT   +   D  +KV
Sbjct: 158 RLIVSASDDKTVKLWDKSSREC--VHSYC--EHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213

Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
           WD+    +L  Y+ H+A V  ++  P   +  ++ S D+ + + D
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 34/232 (14%)

Query: 93  GILVASDSG--AVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150
           G L+AS S    ++LW+    E +       + HD  VS+V+++ +G   VS S+D  IK
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTM----HGHDHNVSSVAIMPNGDHIVSASRDKTIK 217

Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQIGCS 209
           +W++     + ++  H   V  V   P++D   + SCS D  + +W     +  +++   
Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVATKECKAEL--R 273

Query: 210 APGYLPTSLAWHPQQS-------------------EVFVFGDENGTVSLVDTKSTSCVLS 250
              ++   ++W P+ S                      + G  + T+ + D  +  C+++
Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333

Query: 251 SAVHSQCVTGLVFSPHS-VPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300
              H   V G++F  HS   F+ S ++D +L V D       ++  AH  FV
Sbjct: 334 LVGHDNWVRGVLF--HSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 54/230 (23%), Positives = 85/230 (36%), Gaps = 18/230 (7%)

Query: 97  ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156
           AS+   +++W+ +  +     K     H D V  +S   SG    S S D+ IK+WD   
Sbjct: 126 ASEDATIKVWDYETGDFERTLK----GHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181

Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR---CPKPASQIGCSAPGY 213
              + +   H   V+ VA  P+ D + +S S D  I +W+ +   C K       +  G+
Sbjct: 182 FECIRTMHGHDHNVSSVAIMPNGDHI-VSASRDKTIKMWEVQTGYCVK-------TFTGH 233

Query: 214 LPTSLAWHPQQSEVFVFGDENG-TVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 272
                   P Q    +    N  TV +    +  C      H   V  + ++P S    +
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPES--SYS 291

Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322
           S+SE        S     F     RD             L+T VG D+ V
Sbjct: 292 SISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 12/171 (7%)

Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR-- 198
           VS S+D  IKVWD        + + H   V  ++   H   +  SCS D  I LWD +  
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGF 182

Query: 199 -CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQC 257
            C +           +  +S+A  P    + V    + T+ + + ++  CV +   H + 
Sbjct: 183 ECIRT-----MHGHDHNVSSVAIMPNGDHI-VSASRDKTIKMWEVQTGYCVKTFTGHREW 236

Query: 258 VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSP 307
           V  +V        +AS S D ++ V   +  E     + H   V   +W+P
Sbjct: 237 VR-MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP 286



 Score = 32.7 bits (73), Expect = 0.48
 Identities = 32/135 (23%), Positives = 60/135 (44%), Gaps = 12/135 (8%)

Query: 67  APNEGFCSAGVQTEAGVADLTWVGERG--ILVASDSGAVELWELDENETLIVSKFCKYEH 124
           AP   + S    +EA  ++    G+ G  +L  S    +++W++     L+        H
Sbjct: 285 APESSYSSI---SEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL----VGH 337

Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF- 183
           D+ V  V   S G   +S + D  ++VWD   +  + +  AH   VT  +   HK + + 
Sbjct: 338 DNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVT--SLDFHKTAPYV 395

Query: 184 LSCSEDNRILLWDTR 198
           ++ S D  + +W+ R
Sbjct: 396 VTGSVDQTVKVWECR 410


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 14/194 (7%)

Query: 90  GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149
           G + +   SD G V+LW++ +   +       +++   V  V+   +  Q +SG  D  I
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQT-----FQNTYQVLAVTFNDTSDQIISGGIDNDI 217

Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209
           KVWDL Q  +  + R HA  VT ++ S  + S  LS + DN + +WD R   P  +    
Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLS-SEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI 276

Query: 210 APGYLPT------SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263
             G +          +W P  S++   G  +  V + DT S   +     H+  +  + F
Sbjct: 277 FQGNVHNFEKNLLRCSWSPDGSKI-AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAF 335

Query: 264 SPHSVPFLASLSED 277
            P   P + S S D
Sbjct: 336 HPDE-PIIISASSD 348



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 41/194 (21%), Positives = 77/194 (39%), Gaps = 16/194 (8%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H   V  +   + G+   S S D  + VWD      +   + H + V     +     + 
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
            + S+D  + LWD R  K A Q   +   Y   ++ ++    ++   G +N  + + D +
Sbjct: 168 CTGSDDGTVKLWDIR-KKAAIQTFQNT--YQVLAVTFNDTSDQIISGGIDN-DIKVWDLR 223

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-------SSLSELFRSQAH 296
                 +   H+  VTGL  S     +L S + D ++ V D           ++F+   H
Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSEG-SYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVH 282

Query: 297 ---RDFVRDATWSP 307
              ++ +R  +WSP
Sbjct: 283 NFEKNLLR-CSWSP 295


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 59/249 (23%), Positives = 103/249 (41%), Gaps = 14/249 (5%)

Query: 82  GVADLTWV--GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139
           G+ D+TW    E  ++  S  G+++LW  D  +     +  K    ++ S     + G Q
Sbjct: 69  GLFDVTWSENNEHVLITCSGDGSLQLW--DTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQ 126

Query: 140 -AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198
             VSGS D  +K+WD      L ++R H + +     SPH    F S S D  + +WD +
Sbjct: 127 LVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186

Query: 199 CPKPASQIGCSAPGYLPTSLA--WHPQQSEVFVFGDENGTVSLVDTKST-SCVLSSAVHS 255
               A+ +    P +    L+  W      + V G  + ++   D ++    V     H+
Sbjct: 187 ----AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHT 242

Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL--SELFRSQAHRDFVRDATWSPLNHSLL 313
             +  + FSP     LAS S D ++   + S   S L   + H +F     +S  + + +
Sbjct: 243 YAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQV 302

Query: 314 TTVGWDHQV 322
               WD  +
Sbjct: 303 ADCSWDETI 311


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 49/184 (26%), Positives = 84/184 (45%), Gaps = 13/184 (7%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H + V +V+   +G    SGS D  ++ WDL+ +    + + H   V  ++ SP    + 
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAWHP----QQSEVFVFGDENGTV 237
             C ++ +ILLWD   P    Q+G +  G+    T L+W P     +        ++G+V
Sbjct: 173 SGC-KNGQILLWD---PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228

Query: 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAH 296
            + DT +  C      H+Q VT L +    +  L S S+D ++ V  +    L R+ Q H
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDGL--LYSASQDRTIKVWRAHDGVLCRTLQGH 286

Query: 297 RDFV 300
             +V
Sbjct: 287 GHWV 290



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 39/127 (30%), Positives = 56/127 (44%), Gaps = 7/127 (5%)

Query: 141 VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199
           VSGS D  + +W  A+ +  L+    H A +  V  SP    +  S S D  I LWD R 
Sbjct: 345 VSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS-RIVASASFDKSIKLWDGRT 403

Query: 200 PKP-ASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258
            K  AS  G  A  Y    +AW    S + V G  + T+ + D K+    +    H+  V
Sbjct: 404 GKYLASLRGHVAAVY---QIAWSAD-SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459

Query: 259 TGLVFSP 265
             + +SP
Sbjct: 460 YAVDWSP 466



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 36/140 (25%), Positives = 56/140 (40%), Gaps = 10/140 (7%)

Query: 90  GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149
           G   ++  SD   + LW   E++  +        H  +++ V          S S D  I
Sbjct: 340 GPERLVSGSDDFTLFLWSPAEDKKPLTRMT---GHQALINQVLFSPDSRIVASASFDKSI 396

Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209
           K+WD      L+S R H A V  +A S     + +S S D+ + +WD +  K A  +   
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWDVKAQKLAMDL--- 452

Query: 210 APGYLPTSLA--WHPQQSEV 227
            PG+     A  W P    V
Sbjct: 453 -PGHADEVYAVDWSPDGQRV 471



 Score = 35.4 bits (80), Expect = 0.074
 Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 2/64 (3%)

Query: 245 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDA 303
           T C  S   HS+ V  + FSP +  +LAS S D ++   D S+ +  F  + HR +V   
Sbjct: 104 TRCTSSLEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSI 162

Query: 304 TWSP 307
           +WSP
Sbjct: 163 SWSP 166



 Score = 35.0 bits (79), Expect = 0.097
 Identities = 30/107 (28%), Positives = 45/107 (42%), Gaps = 6/107 (5%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKY-----EHDDIVSTVSVLSSGTQAVSGSKDIC 148
           +L + DS  V     D++  L   +  KY      H   V  ++  +     VSGS D  
Sbjct: 378 VLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDST 437

Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
           +KVWD+  Q +      HA +V  V  SP    V  S  +D  + +W
Sbjct: 438 LKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 483


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 14/178 (7%)

Query: 91  ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150
           E  I+  S SG++ +W+L+  + L         H   + ++     G    SGS+D  IK
Sbjct: 75  EELIVAGSQSGSIRVWDLEAAKILRTLM----GHKANICSLDFHPYGEFVASGSQDTNIK 130

Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQIGCS 209
           +WD+ ++  +  YR H+  V C+  SP  D  +L S ++D+ + LWD    K  S+    
Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSP--DGKWLASAADDHTVKLWDLTAGKMMSEF--- 185

Query: 210 APGYL-PTSLA-WHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 265
            PG+  P ++  +HP +  +   G  + T+   D +    V         V  ++F+P
Sbjct: 186 -PGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 41/167 (24%), Positives = 76/167 (45%), Gaps = 9/167 (5%)

Query: 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLS 185
           ++ S V   +SG    +G  D  + +W + +   + S   H + V  V  +   + + ++
Sbjct: 22  NVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT-PEELIVA 80

Query: 186 CSEDNRILLWDTRCPKPASQIGCSAPGYLPT--SLAWHPQQSEVFVFGDENGTVSLVDTK 243
            S+   I +WD      A++I  +  G+     SL +HP   E    G ++  + L D +
Sbjct: 81  GSQSGSIRVWDLE----AAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIKLWDIR 135

Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL 290
              CV     HSQ V  L FSP    +LAS ++D ++ + D +  ++
Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDG-KWLASAADDHTVKLWDLTAGKM 181



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 5/107 (4%)

Query: 92  RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151
           R +    D   V LW +++   ++        H   V +V + +     V+GS+   I+V
Sbjct: 34  RLLATGGDDCRVNLWSINKPNCIMSLT----GHTSPVESVRLNTPEELIVAGSQSGSIRV 89

Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198
           WDL    +L +   H A +  +   P+ + V  S S+D  I LWD R
Sbjct: 90  WDLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIR 135



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 38/160 (23%), Positives = 68/160 (42%), Gaps = 8/160 (5%)

Query: 165 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYL-PTSLAWHPQ 223
           AHA+ V+ +        +  +  +D R+ LW    P        S  G+  P        
Sbjct: 18  AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI----MSLTGHTSPVESVRLNT 73

Query: 224 QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283
             E+ V G ++G++ + D ++   + +   H   +  L F P+   F+AS S+D ++ + 
Sbjct: 74  PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIKLW 132

Query: 284 DSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322
           D      +FR + H   VR   +SP +   L +   DH V
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTV 171



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 5/104 (4%)

Query: 97  ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156
           A+D   V+LW+L   +  ++S+F    H   V+ V    +     SGS D  I+ WDL +
Sbjct: 165 AADDHTVKLWDLTAGK--MMSEFPG--HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220

Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRC 199
             V+S        V  V  +P    ++  C +  R+  W+  RC
Sbjct: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERC 264


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 23/223 (10%)

Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168
           D+NE +   K     H + +S  S  +S  Q ++ S D    +WD+    +L S+  H A
Sbjct: 137 DKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGA 196

Query: 169 QVTCVAASPHK-DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227
            V C+  +P +  + F+S   D + ++WD R  +               S+ ++P   + 
Sbjct: 197 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI--NSVRYYP-SGDA 253

Query: 228 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF------LASLSEDCSLA 281
           F  G ++ T  L D ++   V   A++S+    ++F   SV F      L +   D ++ 
Sbjct: 254 FASGSDDATCRLYDLRADREV---AIYSK--ESIIFGASSVDFSLSGRLLFAGYNDYTIN 308

Query: 282 VLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320
           V D    S +S LF    H + V     SP + +   +  WDH
Sbjct: 309 VWDVLKGSRVSILF---GHENRVSTLRVSP-DGTAFCSGSWDH 347



 Score = 28.5 bits (62), Expect = 9.1
 Identities = 13/31 (41%), Positives = 19/31 (61%)

Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152
           + H++ VST+ V   GT   SGS D  ++VW
Sbjct: 322 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 23/223 (10%)

Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168
           D+NE +   K     H + +S  S  +S  Q ++ S D    +WD+    +L S+  H A
Sbjct: 179 DKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGA 238

Query: 169 QVTCVAASPHK-DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227
            V C+  +P +  + F+S   D + ++WD R  +               S+ ++P   + 
Sbjct: 239 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI--NSVRYYP-SGDA 295

Query: 228 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF------LASLSEDCSLA 281
           F  G ++ T  L D ++   V   A++S+    ++F   SV F      L +   D ++ 
Sbjct: 296 FASGSDDATCRLYDLRADREV---AIYSK--ESIIFGASSVDFSLSGRLLFAGYNDYTIN 350

Query: 282 VLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320
           V D    S +S LF    H + V     SP + +   +  WDH
Sbjct: 351 VWDVLKGSRVSILF---GHENRVSTLRVSP-DGTAFCSGSWDH 389



 Score = 28.5 bits (62), Expect = 9.1
 Identities = 13/31 (41%), Positives = 19/31 (61%)

Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152
           + H++ VST+ V   GT   SGS D  ++VW
Sbjct: 364 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 59/222 (26%), Positives = 90/222 (40%), Gaps = 11/222 (4%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
           H   V +   L+  +  +S S+D+ I+ WDL        Y+ HA  V  +  SP+    F
Sbjct: 341 HCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY-SLYF 399

Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAWHPQQSEVFVFGDENGTVSLVD 241
            S S D    LW      P         G+L     + +HP  S     G  + TV L  
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYA----GHLADVDCVKFHP-NSNYLATGSTDKTVRLWS 454

Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300
            +  + V     H   V  L FSP+   +LAS  ED  L + D +   L++  + H D +
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNG-KYLASAGEDQRLKLWDLASGTLYKELRGHTDNI 513

Query: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342
              T+SP +  L+ +   D+ V    +      AP   S +E
Sbjct: 514 TSLTFSP-DSGLIASASMDNSVRVWDIRNTYCSAPADGSSSE 554



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 13/194 (6%)

Query: 93  GILVASDSGAVELWELDENETLIVSKFCKYEHDDI-VSTVSVLSSGTQAVSGSKDICIKV 151
           G+L  S+  ++  W+L      ++ +   Y   D+ +S  S+  +     SGS D   ++
Sbjct: 356 GLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFA-----SGSHDRTARL 410

Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-GCSA 210
           W   +   L  Y  H A V CV   P+  +   + S D  + LW  +         G   
Sbjct: 411 WSFDRTYPLRIYAGHLADVDCVKFHPN-SNYLATGSTDKTVRLWSAQQGNSVRLFTGHRG 469

Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF 270
           P     SLA+ P   +      E+  + L D  S +       H+  +T L FSP S   
Sbjct: 470 P---VLSLAFSP-NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS-GL 524

Query: 271 LASLSEDCSLAVLD 284
           +AS S D S+ V D
Sbjct: 525 IASASMDNSVRVWD 538



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 8/113 (7%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           +   S    V LW   +  ++ +       H   V +++   +G    S  +D  +K+WD
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFT----GHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496

Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR---CPKPA 203
           LA   +    R H   +T +  SP    +  S S DN + +WD R   C  PA
Sbjct: 497 LASGTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDIRNTYCSAPA 548


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 19/234 (8%)

Query: 82  GVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140
           G++D+ W  +  +LV ASD   +++W++   + L   K     H + V   +        
Sbjct: 89  GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSNLI 144

Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--- 197
           VSGS D  +++WD+     L +  AH+  V+ V  +    S+ +S S D    +WDT   
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASG 203

Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ- 256
           +C K  + I    P   P S        +  +    + T+ L D     C+ +   H   
Sbjct: 204 QCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258

Query: 257 --CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 307
             C+    FS     ++ S SED  + + +    E+ +  Q H D V      P
Sbjct: 259 KYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 2/107 (1%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           IL A+    ++LW+  + + L      K E   I +  SV + G   VSGS+D  + +W+
Sbjct: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWN 287

Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE-DNRILLWDTRC 199
           L  + ++   + H   V   A  P ++ +  +  E D  I LW + C
Sbjct: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 19/234 (8%)

Query: 82  GVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140
           G++D+ W  +  +LV ASD   +++W++   + L   K     H + V   +        
Sbjct: 89  GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSNLI 144

Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--- 197
           VSGS D  +++WD+     L +  AH+  V+ V  +    S+ +S S D    +WDT   
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASG 203

Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ- 256
           +C K  + I    P   P S        +  +    + T+ L D     C+ +   H   
Sbjct: 204 QCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258

Query: 257 --CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 307
             C+    FS     ++ S SED  + + +    E+ +  Q H D V      P
Sbjct: 259 KYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 2/107 (1%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           IL A+    ++LW+  + + L      K E   I +  SV + G   VSGS+D  + +W+
Sbjct: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWN 287

Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE-DNRILLWDTRC 199
           L  + ++   + H   V   A  P ++ +  +  E D  I LW + C
Sbjct: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 43/169 (25%), Positives = 80/169 (47%), Gaps = 10/169 (5%)

Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGYLPT--SL 218
           R H  +   ++ +P+     LS S+D+ I LWD +  PK    +       G+      +
Sbjct: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198

Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275
           +WH     +F    ++  + + DT+S +    S     H+  V  L F+P+S   LA+ S
Sbjct: 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 258

Query: 276 EDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322
            D ++A+ D  +   +L   ++H+D +    WSP N ++L + G D ++
Sbjct: 259 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 28/206 (13%)

Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193
           +S S D  I +WD++      +VV +   +  H A V  V+     +S+F S ++D +++
Sbjct: 159 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 218

Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250
           +WDTR     KP+  +           L+++P    +   G  + TV+L D ++    L 
Sbjct: 219 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 276

Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294
           S   H   +  + +SPH+   LAS   D  L V D S + E              LF   
Sbjct: 277 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 336

Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320
            H   + D +W+P    ++ +V  D+
Sbjct: 337 GHTAKISDFSWNPNEPWVICSVSEDN 362



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 24/178 (13%)

Query: 36  YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85
           ++ +G  L    +LSG   + S      LW   D  A P EG          G    V D
Sbjct: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 197

Query: 86  LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140
           ++W  + E      +D   + +W+   N T   S    +  D   + V+ LS    +   
Sbjct: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS----HSVDAHTAEVNCLSFNPYSEFI 253

Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
             +GS D  + +WDL   ++ L S+ +H  ++  V  SPH +++  S   D R+ +WD
Sbjct: 254 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 94  ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149
           +L ASD   + LW++    +   ++ +K     H  +V  VS  L   +   S + D  +
Sbjct: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217

Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198
            +WD           S  AH A+V C++ +P+ + +  + S D  + LWD R
Sbjct: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269



 Score = 30.0 bits (66), Expect = 3.1
 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           +   S    V LW+L  N  L +  F  ++ D+I        + T   S   D  + VWD
Sbjct: 254 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 311

Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
           L++                +L  +  H A+++  + +P++  V  S SEDN + +W
Sbjct: 312 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 43/169 (25%), Positives = 80/169 (47%), Gaps = 10/169 (5%)

Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGYLPT--SL 218
           R H  +   ++ +P+     LS S+D+ I LWD +  PK    +       G+      +
Sbjct: 173 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 232

Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275
           +WH     +F    ++  + + DT+S +    S     H+  V  L F+P+S   LA+ S
Sbjct: 233 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 292

Query: 276 EDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322
            D ++A+ D  +   +L   ++H+D +    WSP N ++L + G D ++
Sbjct: 293 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 341



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 28/206 (13%)

Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193
           +S S D  I +WD++      +VV +   +  H A V  V+     +S+F S ++D +++
Sbjct: 193 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 252

Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250
           +WDTR     KP+  +           L+++P    +   G  + TV+L D ++    L 
Sbjct: 253 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 310

Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294
           S   H   +  + +SPH+   LAS   D  L V D S + E              LF   
Sbjct: 311 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 370

Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320
            H   + D +W+P    ++ +V  D+
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDN 396



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 24/178 (13%)

Query: 36  YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85
           ++ +G  L    +LSG   + S      LW   D  A P EG          G    V D
Sbjct: 175 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 231

Query: 86  LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140
           ++W  + E      +D   + +W+   N T   S    +  D   + V+ LS    +   
Sbjct: 232 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS----HSVDAHTAEVNCLSFNPYSEFI 287

Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
             +GS D  + +WDL   ++ L S+ +H  ++  V  SPH +++  S   D R+ +WD
Sbjct: 288 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 345



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 94  ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149
           +L ASD   + LW++    +   ++ +K     H  +V  VS  L   +   S + D  +
Sbjct: 192 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 251

Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198
            +WD           S  AH A+V C++ +P+ + +  + S D  + LWD R
Sbjct: 252 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303



 Score = 30.0 bits (66), Expect = 3.1
 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           +   S    V LW+L  N  L +  F  ++ D+I        + T   S   D  + VWD
Sbjct: 288 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 345

Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
           L++                +L  +  H A+++  + +P++  V  S SEDN + +W
Sbjct: 346 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 401


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 43/169 (25%), Positives = 80/169 (47%), Gaps = 10/169 (5%)

Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGYLPT--SL 218
           R H  +   ++ +P+     LS S+D+ I LWD +  PK    +       G+      +
Sbjct: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233

Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275
           +WH     +F    ++  + + DT+S +    S     H+  V  L F+P+S   LA+ S
Sbjct: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293

Query: 276 EDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322
            D ++A+ D  +   +L   ++H+D +    WSP N ++L + G D ++
Sbjct: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 28/206 (13%)

Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193
           +S S D  I +WD++      +VV +   +  H A V  V+     +S+F S ++D +++
Sbjct: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253

Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250
           +WDTR     KP+  +           L+++P    +   G  + TV+L D ++    L 
Sbjct: 254 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311

Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294
           S   H   +  + +SPH+   LAS   D  L V D S + E              LF   
Sbjct: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 371

Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320
            H   + D +W+P    ++ +V  D+
Sbjct: 372 GHTAKISDFSWNPNEPWVICSVSEDN 397



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 24/178 (13%)

Query: 36  YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85
           ++ +G  L    +LSG   + S      LW   D  A P EG          G    V D
Sbjct: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 232

Query: 86  LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140
           ++W  + E      +D   + +W+   N T   S    +  D   + V+ LS    +   
Sbjct: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS----HSVDAHTAEVNCLSFNPYSEFI 288

Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
             +GS D  + +WDL   ++ L S+ +H  ++  V  SPH +++  S   D R+ +WD
Sbjct: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 94  ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149
           +L ASD   + LW++    +   ++ +K     H  +V  VS  L   +   S + D  +
Sbjct: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252

Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198
            +WD           S  AH A+V C++ +P+ + +  + S D  + LWD R
Sbjct: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304



 Score = 30.0 bits (66), Expect = 3.1
 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           +   S    V LW+L  N  L +  F  ++ D+I        + T   S   D  + VWD
Sbjct: 289 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 346

Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
           L++                +L  +  H A+++  + +P++  V  S SEDN + +W
Sbjct: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402


>gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens]
          Length = 1205

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%)

Query: 93  GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147
           G+L+A  ++G + L++  +    ++ +++++  K+        V++  +   A SG+ + 
Sbjct: 87  GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145

Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204
            I +WDL   A  +   +       ++C+A +     +  S S   R  +WD R  +P  
Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205

Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260
           ++   +     + LAWHP  +   V   E+  + ++   D +  S  L     H++ +  
Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265

Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319
           + +S      L S  +D  +   + +  E L+    +  +  D  W P N ++L+   +D
Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Query: 320 HQV 322
            ++
Sbjct: 326 GRI 328


>gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens]
          Length = 1220

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%)

Query: 93  GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147
           G+L+A  ++G + L++  +    ++ +++++  K+        V++  +   A SG+ + 
Sbjct: 87  GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145

Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204
            I +WDL   A  +   +       ++C+A +     +  S S   R  +WD R  +P  
Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205

Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260
           ++   +     + LAWHP  +   V   E+  + ++   D +  S  L     H++ +  
Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265

Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319
           + +S      L S  +D  +   + +  E L+    +  +  D  W P N ++L+   +D
Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Query: 320 HQV 322
            ++
Sbjct: 326 GRI 328


>gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens]
          Length = 1106

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%)

Query: 93  GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147
           G+L+A  ++G + L++  +    ++ +++++  K+        V++  +   A SG+ + 
Sbjct: 87  GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145

Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204
            I +WDL   A  +   +       ++C+A +     +  S S   R  +WD R  +P  
Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205

Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260
           ++   +     + LAWHP  +   V   E+  + ++   D +  S  L     H++ +  
Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265

Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319
           + +S      L S  +D  +   + +  E L+    +  +  D  W P N ++L+   +D
Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Query: 320 HQV 322
            ++
Sbjct: 326 GRI 328


>gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens]
          Length = 1181

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%)

Query: 93  GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147
           G+L+A  ++G + L++  +    ++ +++++  K+        V++  +   A SG+ + 
Sbjct: 87  GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145

Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204
            I +WDL   A  +   +       ++C+A +     +  S S   R  +WD R  +P  
Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205

Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260
           ++   +     + LAWHP  +   V   E+  + ++   D +  S  L     H++ +  
Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265

Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319
           + +S      L S  +D  +   + +  E L+    +  +  D  W P N ++L+   +D
Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Query: 320 HQV 322
            ++
Sbjct: 326 GRI 328


>gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens]
          Length = 1220

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 14/243 (5%)

Query: 93  GILVAS-DSGAVELWELDE----NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147
           G+L+A  ++G + L++  +    ++ +++++  K+        V++  +   A SG+ + 
Sbjct: 87  GVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA-SGANES 145

Query: 148 CIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204
            I +WDL   A  +   +       ++C+A +     +  S S   R  +WD R  +P  
Sbjct: 146 EIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPII 205

Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAV-HSQCVTG 260
           ++   +     + LAWHP  +   V   E+  + ++   D +  S  L     H++ +  
Sbjct: 206 KVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILA 265

Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319
           + +S      L S  +D  +   + +  E L+    +  +  D  W P N ++L+   +D
Sbjct: 266 IAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Query: 320 HQV 322
            ++
Sbjct: 326 GRI 328


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 54/222 (24%), Positives = 89/222 (40%), Gaps = 21/222 (9%)

Query: 91  ERGILVASDSGAVELWEL-----------DENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139
           E  ++  S    V+LW L           D    L+ ++  +  HD  +++V++  +   
Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKL 493

Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW---D 196
             +GS+D   K+W L Q  +L  +  H   + CV  SP  D V  + S D  I LW   D
Sbjct: 494 LATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSP-MDQVLATASADGTIKLWALQD 552

Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ 256
             C K       S        +A+  + +++   G + G V L   K+  CV +   H  
Sbjct: 553 FSCLKTFEGHDASV-----LKVAFVSRGTQLLSSGSD-GLVKLWTIKNNECVRTLDAHED 606

Query: 257 CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRD 298
            V GL  S      L   S+   +   D + +E    QA ++
Sbjct: 607 KVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQE 648



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 10/118 (8%)

Query: 83  VADLTWVG--ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140
           V D+ ++G  +  ++VAS+S  ++++EL  +   I+     + H DIV  + V   G   
Sbjct: 337 VLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL-----HGHTDIVLALDVFRKGWLF 391

Query: 141 VSGSKDICIKVWDL---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
            S +KD  +++W +    Q + ++    H   V  V  S  K+S  ++ S+D  + LW
Sbjct: 392 ASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449



 Score = 37.7 bits (86), Expect = 0.015
 Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 34/131 (25%)

Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC-- 199
           S + D  I+VW L  +  L+   AH + VT +A S    ++ LS   D   ++WD +   
Sbjct: 170 SSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM-LSSGRDKICIIWDLQSCQ 228

Query: 200 ------------------PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241
                              +P SQ+G  +PG               F+   + GT+ + +
Sbjct: 229 ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGL-------------YFLTAGDQGTLRVWE 275

Query: 242 TKSTSCVLSSA 252
             S  CV + A
Sbjct: 276 AASGQCVYTQA 286


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 40/149 (26%), Positives = 72/149 (48%), Gaps = 10/149 (6%)

Query: 184 LSCSEDNRILLWDTRC-PKPASQIGCSA----PGYLPTSLAWHPQQSEVFVFGDENGTVS 238
           LS S+D+ + LWD    PK    +   A       +   +AWH     +F    ++  + 
Sbjct: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252

Query: 239 LVDTKSTSCVLSSAV---HSQCVTGLVFSPHSVPFLASLSEDCSLAVLD--SSLSELFRS 293
           + DT+S +    S +   H+  V  L F+P+S   LA+ S D ++A+ D  +   +L   
Sbjct: 253 IWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF 312

Query: 294 QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322
           ++H+D +    WSP N ++L + G D ++
Sbjct: 313 ESHKDEIFQVHWSPHNETILASSGTDRRL 341



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 50/206 (24%), Positives = 90/206 (43%), Gaps = 28/206 (13%)

Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193
           +S S D  + +WD+       ++V +   +  H+A V  VA     +S+F S ++D +++
Sbjct: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252

Query: 194 LWDTRC---PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250
           +WDTR     KP+  +           L+++P    +   G  + TV+L D ++    L 
Sbjct: 253 IWDTRSNTTSKPSHLVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 310

Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294
           +   H   +  + +SPH+   LAS   D  L V D S + E              LF   
Sbjct: 311 TFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHG 370

Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDH 320
            H   + D +W+P    ++ +V  D+
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDN 396



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 24/178 (13%)

Query: 36  YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85
           ++ +G  L   S+LSG   + S      LW   D  A P EG          G    V D
Sbjct: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLW---DINAGPKEGKIVDAKAIFTGHSAVVED 231

Query: 86  LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140
           + W  + E      +D   + +W+   N T   S       D   + V+ LS    +   
Sbjct: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLV----DAHTAEVNCLSFNPYSEFI 287

Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
             +GS D  + +WDL   ++ L ++ +H  ++  V  SPH +++  S   D R+ +WD
Sbjct: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 94  ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICI 149
           +L ASD   V LW+++   +   ++ +K     H  +V  V+  L   +   S + D  +
Sbjct: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251

Query: 150 KVWDLAQQVVLSSYR---AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198
            +WD              AH A+V C++ +P+ + +  + S D  + LWD R
Sbjct: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           +   S    V LW+L  N  L +  F  ++ D+I        + T   S   D  + VWD
Sbjct: 288 LATGSADKTVALWDL-RNLKLKLHTFESHK-DEIFQVHWSPHNETILASSGTDRRLNVWD 345

Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
           L++                +L  +  H A+++  + +P++  V  S SEDN + +W
Sbjct: 346 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401


>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
           [Homo sapiens]
          Length = 906

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 47/210 (22%), Positives = 93/210 (44%), Gaps = 30/210 (14%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS-YRAHAAQVTCVAASPHKDSV 182
           H D +  ++V  +    ++ S D+ IK+WD  ++   S  +  H   V  +  +P  ++ 
Sbjct: 98  HSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQ 157

Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ-----------QSEVFVFG 231
           F S S D  I +W         Q+G S+P +   +L  H +                + G
Sbjct: 158 FASASLDRTIKVW---------QLGSSSPNF---TLEGHEKGVNCIDYYSGGDKPYLISG 205

Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291
            ++  V + D ++ +CV +   H+Q V+   F P  +P + + SED ++ +  SS    +
Sbjct: 206 ADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIWHSS---TY 261

Query: 292 RSQAHRDFVRDATW--SPLNHSLLTTVGWD 319
           R ++  ++  +  W  + L  S    +G+D
Sbjct: 262 RLESTLNYGMERVWCVASLRGSNNVALGYD 291



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 24/101 (23%), Positives = 47/101 (46%), Gaps = 7/101 (6%)

Query: 97  ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--VSGSKDICIKVWDL 154
           AS    +++W+L  +       F    H+  V+ +   S G +   +SG+ D  +K+WD 
Sbjct: 161 ASLDRTIKVWQLGSSSP----NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY 216

Query: 155 AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195
             +  + +   HA  V+C +  P    + ++ SED  + +W
Sbjct: 217 QNKTCVQTLEGHAQNVSCASFHPEL-PIIITGSEDGTVRIW 256



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 35/147 (23%), Positives = 62/147 (42%), Gaps = 6/147 (4%)

Query: 94  ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153
           IL +SD   ++LW+ D+  +   S+  +     ++  V       Q  S S D  IKVW 
Sbjct: 114 ILTSSDDMLIKLWDWDKKWSC--SQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171

Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL-LWDTRCPKPASQIGCSAPG 212
           L       +   H   V C+      D  +L    D+R++ +WD +       +   A  
Sbjct: 172 LGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQN 231

Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSL 239
              +  ++HP +  + + G E+GTV +
Sbjct: 232 V--SCASFHP-ELPIIITGSEDGTVRI 255



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 44/196 (22%), Positives = 90/196 (45%), Gaps = 9/196 (4%)

Query: 91  ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDI-VSTVSVLSSGTQAVSGSKDICI 149
           E  +L +  +G+V +W   E +TL+ +    +E  D+ V     ++     V+G+ D+ I
Sbjct: 27  EPWMLASLYNGSVCVWN-HETQTLVKT----FEVCDLPVRAAKFVARKNWVVTGADDMQI 81

Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209
           +V++      +  + AH+  + C+A  P +  + L+ S+D  I LWD       SQ+   
Sbjct: 82  RVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFI-LTSSDDMLIKLWDWDKKWSCSQVFEG 140

Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL-VFSPHSV 268
              Y+   +  +P+ +  F     + T+ +    S+S   +   H + V  +  +S    
Sbjct: 141 HTHYV-MQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDK 199

Query: 269 PFLASLSEDCSLAVLD 284
           P+L S ++D  + + D
Sbjct: 200 PYLISGADDRLVKIWD 215



 Score = 28.5 bits (62), Expect = 9.1
 Identities = 29/129 (22%), Positives = 59/129 (45%), Gaps = 7/129 (5%)

Query: 66  AAPNEGFCSAGVQTEAGVADLTWVGERGILVA-SDSGAVELWELDENETLIVSKFCKYEH 124
           ++PN  F   G +      D    G++  L++ +D   V++W+  +N+T + +      H
Sbjct: 175 SSPN--FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY-QNKTCVQTL---EGH 228

Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184
              VS  S        ++GS+D  +++W  +   + S+      +V CVA+    ++V L
Sbjct: 229 AQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVAL 288

Query: 185 SCSEDNRIL 193
              E + I+
Sbjct: 289 GYDEGSIIV 297


>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
           sapiens]
          Length = 387

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 13/235 (5%)

Query: 102 AVELWELDENET---LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
           A E+W +  +     ++ + + +     +++  +V     +  SGS +        AQ +
Sbjct: 64  AGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTL 123

Query: 159 VLSSYRAHAAQ--VTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP----G 212
            L  +  + A   + CV   P  D   +    DN ILLWD +     + +  SA     G
Sbjct: 124 ELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183

Query: 213 YLP-TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQCVTGLVFSPHSVPF 270
            L  TS  W P  +   V    + T+   DT+S S +      H Q V  L F+P+   +
Sbjct: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYY 243

Query: 271 LASLSEDCSLAVLDS-SLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323
           LAS  +DC +   D+ +++E  ++ + H  +V +  ++  +  L+ T   D +V+
Sbjct: 244 LASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVI 298



 Score = 35.0 bits (79), Expect = 0.097
 Identities = 51/267 (19%), Positives = 103/267 (38%), Gaps = 20/267 (7%)

Query: 70  EGFCSAGVQTEAGVADLTW--VGERGILVASDSGAVELWELDENET-LIVSKFCKYEHDD 126
           E  C         +A + W  +G+   +++     + LW+L E+ +  +++     E   
Sbjct: 124 ELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183

Query: 127 IVSTVSVLSS---GTQAVSGSKDICIKVWDL-AQQVVLSSYRAHAAQVTCVAASPHKDSV 182
            +   S   S       V+ + D  ++ WD  +   +     AH   V  +  +P+K   
Sbjct: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYY 243

Query: 183 FLSCSEDNRILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241
             SC +D ++  WDTR   +P   +      +   ++ ++    ++ + G  +  V L +
Sbjct: 244 LASCGDDCKVKFWDTRNVTEPVKTL--EEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSN 301

Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVR 301
             S S        S+    LV            SE+ S   L  ++   +  + H D V 
Sbjct: 302 MVSIS--------SEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATY--EEHEDSVY 351

Query: 302 DATWSPLNHSLLTTVGWDHQVVHHVVP 328
              WS  +  L  ++ +D ++V + VP
Sbjct: 352 AVDWSSADPWLFASLSYDGRLVINRVP 378


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 35/146 (23%), Positives = 65/146 (44%), Gaps = 9/146 (6%)

Query: 81  AGVADLTWVGERGILVASDSGA---VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSG 137
           A V  + W   +G++V+    +   ++ W+    ++L       + H + V  V +  +G
Sbjct: 245 ADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATL----HAHKNTVMEVKLNLNG 300

Query: 138 TQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196
              ++ S+D   K++D+   +  L  +R H  + T VA  P  + +F S   D  +L W 
Sbjct: 301 NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360

Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHP 222
               K    +  +  G +  SLAWHP
Sbjct: 361 VGVEKEVGGMEMAHEGMI-WSLAWHP 385



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 58/250 (23%), Positives = 98/250 (39%), Gaps = 19/250 (7%)

Query: 88  WVGE-RGILVASDSGAVELWE-LDEN-ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144
           W  E R ++  + SG   LW  L  N ET++ +      HD  V  ++   +    ++  
Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQA------HDSPVRAMTWSHNDMWMLTAD 180

Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPA 203
               +K W      V   ++AH   +   + SP  D+ F +CS+D  + +WD  RC +  
Sbjct: 181 HGGYVKYWQSNMNNV-KMFQAHKEAIREASFSP-TDNKFATCSDDGTVRIWDFLRCHEER 238

Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFG--DENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261
              G  A       + WHP +  V V G  D    +   D K+   + +   H   V  +
Sbjct: 239 ILRGHGAD---VKCVDWHPTKGLV-VSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEV 294

Query: 262 VFSPHSVPFL-ASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320
             + +    L AS    C L  + +   EL   + H+       W P++  L  + G D 
Sbjct: 295 KLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDG 354

Query: 321 QVVHHVVPTE 330
            ++   V  E
Sbjct: 355 SLLFWHVGVE 364



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 58/277 (20%), Positives = 99/277 (35%), Gaps = 26/277 (9%)

Query: 42  LLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWV-GERGILVASDS 100
           L+ GASS     W G  + F+    A            ++ V  +TW   +  +L A   
Sbjct: 134 LVTGASSGEFTLWNGLTFNFETILQAH-----------DSPVRAMTWSHNDMWMLTADHG 182

Query: 101 GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL 160
           G V+ W+ + N   +        H + +   S   +  +  + S D  +++WD  +    
Sbjct: 183 GYVKYWQSNMNNVKMFQA-----HKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEE 237

Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSCSEDNR--ILLWDTRCPKPASQIGCSAPGYLPTSL 218
              R H A V CV   P K  V +S S+D++  I  WD +  +  + +       +   L
Sbjct: 238 RILRGHGADVKCVDWHPTKGLV-VSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKL 296

Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQCVTGLVFSPHSVPFLASLSED 277
             +       +    +    L D ++    L     H +  T + + P      AS   D
Sbjct: 297 NLN---GNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSD 353

Query: 278 CSLAVLDSSLSELF--RSQAHRDFVRDATWSPLNHSL 312
            SL      + +       AH   +    W PL H L
Sbjct: 354 GSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHIL 390


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 57/236 (24%), Positives = 89/236 (37%), Gaps = 29/236 (12%)

Query: 91  ERGILVASDSGAVELWELDE------NETLIVSKFCKYE-HDDIVSTVSVLSSGTQAVSG 143
           +  +L AS+ G ++LW L +      N  L V     +  H   V  V++ S+     SG
Sbjct: 457 QSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 516

Query: 144 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF-----------LSCSEDNRI 192
             D CI  W +   + +  Y  +   V       H D+V+            SCS D  +
Sbjct: 517 GADACIHSWKIPD-LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 575

Query: 193 LLWDTRCPKPASQIGCSAPGY----LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV 248
            +WD     PA    C+ P      +PTS+A+   +    V    +G   L D +  S +
Sbjct: 576 RIWDPSSSSPACL--CTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSAL 633

Query: 249 L---SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ-AHRDFV 300
           L   S           V S  + P   +  +D  +  LD+   +   S  AH D V
Sbjct: 634 LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV 689



 Score = 30.4 bits (67), Expect = 2.4
 Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 4/60 (6%)

Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ----VTCVAASPHK 179
           H D V+ ++V  +G   +SGS D  +++W L  +  +    AH  +    +  VA  P K
Sbjct: 685 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 744


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.130    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,251,837
Number of Sequences: 37866
Number of extensions: 698509
Number of successful extensions: 3446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 2492
Number of HSP's gapped (non-prelim): 829
length of query: 342
length of database: 18,247,518
effective HSP length: 103
effective length of query: 239
effective length of database: 14,347,320
effective search space: 3429009480
effective search space used: 3429009480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.