Guide to the Human Genome
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Search of human proteins with 4557729

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557729 voltage-gated potassium channel, subfamily H, member
2 isoform a [Homo sapiens]
         (1159 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557729 voltage-gated potassium channel, subfamily H, member ...  2346   0.0  
gi|26051271 voltage-gated potassium channel, subfamily H, member...  1611   0.0  
gi|26051273 voltage-gated potassium channel, subfamily H, member...  1598   0.0  
gi|27886653 potassium voltage-gated channel, subfamily H, member...  1234   0.0  
gi|27886665 potassium voltage-gated channel, subfamily H, member...   930   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   926   0.0  
gi|27886651 potassium voltage-gated channel, subfamily H, member...   813   0.0  
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   478   e-134
gi|27886667 potassium voltage-gated channel, subfamily H, member...   477   e-134
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   471   e-132
gi|22024390 potassium voltage-gated channel, subfamily H, member...   463   e-130
gi|27886648 potassium voltage-gated channel, subfamily H, member...   463   e-130
gi|27437001 potassium voltage-gated channel, subfamily H, member...   461   e-129
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   448   e-125
gi|27886646 potassium voltage-gated channel, subfamily H, member...   409   e-114
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   175   3e-43
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   174   3e-43
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   173   1e-42
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   171   3e-42
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   157   4e-38
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   157   4e-38
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   148   3e-35
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   148   3e-35
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    140   9e-33
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    133   9e-31
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    100   1e-20
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    98   4e-20
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       48   5e-05
gi|5031767 heat shock transcription factor 1 [Homo sapiens]            46   2e-04
gi|58530876 melanoma antigen family C, 1 [Homo sapiens]                44   9e-04

>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
            isoform a [Homo sapiens]
          Length = 1159

 Score = 2346 bits (6079), Expect = 0.0
 Identities = 1159/1159 (100%), Positives = 1159/1159 (100%)

Query: 1    MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
            MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
Sbjct: 1    MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61   QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
            QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
Sbjct: 61   QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121  AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
            AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV
Sbjct: 121  AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180

Query: 181  RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240
            RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP
Sbjct: 181  RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240

Query: 241  PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300
            PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP
Sbjct: 241  PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300

Query: 301  RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360
            RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA
Sbjct: 301  RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360

Query: 361  PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420
            PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY
Sbjct: 361  PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420

Query: 421  TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480
            TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE
Sbjct: 421  TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480

Query: 481  EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540
            EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD
Sbjct: 481  EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540

Query: 541  RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600
            RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS
Sbjct: 541  RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600

Query: 601  GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660
            GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS
Sbjct: 601  GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660

Query: 661  AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720
            AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF
Sbjct: 661  AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720

Query: 721  PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780
            PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY
Sbjct: 721  PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780

Query: 781  FISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE 840
            FISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE
Sbjct: 781  FISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE 840

Query: 841  VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTE 900
            VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTE
Sbjct: 841  VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTE 900

Query: 901  QPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSS 960
            QPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSS
Sbjct: 901  QPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSS 960

Query: 961  PRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTP 1020
            PRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTP
Sbjct: 961  PRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTP 1020

Query: 1021 SLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSA 1080
            SLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSA
Sbjct: 1021 SLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSA 1080

Query: 1081 VTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPG 1140
            VTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPG
Sbjct: 1081 VTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPG 1140

Query: 1141 QLGALTSQPLHRHGSDPGS 1159
            QLGALTSQPLHRHGSDPGS
Sbjct: 1141 QLGALTSQPLHRHGSDPGS 1159


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score = 1611 bits (4172), Expect = 0.0
 Identities = 800/800 (100%), Positives = 800/800 (100%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
Sbjct: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
Sbjct: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
           AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV
Sbjct: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180

Query: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240
           RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP
Sbjct: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240

Query: 241 PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300
           PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP
Sbjct: 241 PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300

Query: 301 RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360
           RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA
Sbjct: 301 RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360

Query: 361 PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420
           PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY
Sbjct: 361 PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420

Query: 421 TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480
           TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE
Sbjct: 421 TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480

Query: 481 EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540
           EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD
Sbjct: 481 EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540

Query: 541 RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600
           RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS
Sbjct: 541 RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600

Query: 601 GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660
           GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS
Sbjct: 601 GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660

Query: 661 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720
           AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF
Sbjct: 661 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720

Query: 721 PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780
           PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY
Sbjct: 721 PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780

Query: 781 FISRGSIEILRGDVVVAILG 800
           FISRGSIEILRGDVVVAILG
Sbjct: 781 FISRGSIEILRGDVVVAILG 800


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
            isoform c [Homo sapiens]
          Length = 819

 Score = 1598 bits (4138), Expect = 0.0
 Identities = 783/784 (99%), Positives = 784/784 (100%)

Query: 376  QVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 435
            +VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE
Sbjct: 36   EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95

Query: 436  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 495
            TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK
Sbjct: 96   TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155

Query: 496  GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 555
            GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC
Sbjct: 156  GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 215

Query: 556  TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615
            TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL
Sbjct: 216  TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275

Query: 616  YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
            YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT
Sbjct: 276  YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335

Query: 676  QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
            QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS
Sbjct: 336  QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395

Query: 736  LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
            LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV
Sbjct: 396  LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455

Query: 796  VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS 855
            VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS
Sbjct: 456  VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS 515

Query: 856  LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 915
            LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA
Sbjct: 516  LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 575

Query: 916  GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 975
            GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME
Sbjct: 576  GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 635

Query: 976  DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 1035
            DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR
Sbjct: 636  DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 695

Query: 1036 GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL 1095
            GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL
Sbjct: 696  GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL 755

Query: 1096 PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS 1155
            PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS
Sbjct: 756  PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS 815

Query: 1156 DPGS 1159
            DPGS
Sbjct: 816  DPGS 819


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
            isoform 1 [Homo sapiens]
          Length = 1196

 Score = 1234 bits (3192), Expect = 0.0
 Identities = 679/1113 (61%), Positives = 795/1113 (71%), Gaps = 69/1113 (6%)

Query: 1    MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
            MPVRRGHVAPQNTFL TIIRKFEGQ++KFIIANARV+NCA+IYCNDGFCE+ G+SR +VM
Sbjct: 1    MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61   QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
            Q+PCTCDFLHGP T+R   AQIAQALLG+EERKVE+ +Y K+GS F+C   ++PVKN++G
Sbjct: 61   QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121  AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
              +MFI+NFE V + +   +P      R  P   +     K F  K P L  LT R+ S+
Sbjct: 121  VAMMFIINFEYVTDNENAATP-----ERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSL 175

Query: 181  RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPG-- 238
                      P  VV+D     +  S +S+A+    +          A++ +AL+ P   
Sbjct: 176  PQED------PDVVVID----SSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKC 225

Query: 239  SPPRSAPGQL----PSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAG 294
            SP  +  G L    P  +   L PD   SS  L+ +RSRES  S+RRASS  DIE    G
Sbjct: 226  SPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGF--G 283

Query: 295  VLPPP---PRHAST-------GAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLK 344
            V P      RHAS        G  + ++S LL STSDS+L +Y TI+KIPQ+TLNF ++K
Sbjct: 284  VHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVK 343

Query: 345  GDPFLASP-TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHY 403
             +   +SP +SD+ IIAPK+K+RTHNVTEKVTQVLSLGADVLPEYKLQ PRI+++TILHY
Sbjct: 344  TEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHY 403

Query: 404  SPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMF 463
            SPFKAVWDWLILLLVIYTA+FTPYSAAFLL + EE     ECGY+C PL VVDLIVDIMF
Sbjct: 404  SPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMF 462

Query: 464  IVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---L 520
            I+DILINFRTTYVN NEEVVS P +IA+HYFKGWFLIDMVAAIPFDLLIFGSGS+E   L
Sbjct: 463  IIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTL 522

Query: 521  IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 580
            IGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAHWLACIWYAIGN+E+P++ 
Sbjct: 523  IGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLT 582

Query: 581  SRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 639
             +IGWL +LG QIGK YN S    GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI
Sbjct: 583  DKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 642

Query: 640  FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEE 699
            FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRV+EFIRFHQIPNPLRQRLEE
Sbjct: 643  FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEE 702

Query: 700  YFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFK 759
            YFQHAW+YTNGIDMN VLKGFPECLQADICLHLN++LLQ+CK FRGA+KGCLRALAMKFK
Sbjct: 703  YFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFK 762

Query: 760  TTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSN 819
            TTHAPPGDTLVH GD+LTALYF+SRGSIEIL+ D+VVAILGKNDIFGE ++LYA+PGKSN
Sbjct: 763  TTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSN 822

Query: 820  GDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNM---IPGSPGSTE 876
             DVRALTYCDLHKI R+DLLEVLDMYPEFSDHF ++LE+TFNLR  +    +  S    +
Sbjct: 823  ADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMND 882

Query: 877  LEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPS 936
             EG   + R+RKLSF    +K+        +    R              + E  S   S
Sbjct: 883  SEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSKRH------FEEKKSRSSS 936

Query: 937  SPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSN 996
               S +DE            P  S      P  G+    D E++     P SG       
Sbjct: 937  FISSIDDEQK----------PLFSGIVDSSPGIGKASGLDFEETV----PTSGRMHIDKR 982

Query: 997  IFSFWGDSRGRQYQELPRCPAP---TPSLLNIPL----SSPGRRPRGDVESRLDALQRQL 1049
              S    +  R ++     P P   +PS L         +      G+VE RLD LQ QL
Sbjct: 983  SHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQL 1042

Query: 1050 NRLETRLSADMATVLQLLQRQMTLVPPAYSAVT 1082
            NRLE++++ D+ T+LQLLQ+Q T+VPPAYS VT
Sbjct: 1043 NRLESQMTTDIQTILQLLQKQTTVVPPAYSMVT 1075


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  930 bits (2403), Expect = 0.0
 Identities = 490/730 (67%), Positives = 564/730 (77%), Gaps = 32/730 (4%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNTFL TIIRKFEGQ++KFIIANARV+NCA+IYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFLHGP T+R   AQIAQALLG+EERKVE+ +Y K+GS F+C   ++PVKN++G
Sbjct: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
             +MFI+NFE V + +   +P      R  P   +     K F  K P L  LT R+ S+
Sbjct: 121 VAMMFIINFEYVTDNENAATP-----ERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSL 175

Query: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPG-- 238
                     P  VV+D     +  S +S+A+    +          A++ +AL+ P   
Sbjct: 176 PQED------PDVVVID----SSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKC 225

Query: 239 SPPRSAPGQL----PSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAG 294
           SP  +  G L    P  +   L PD   SS  L+ +RSRES  S+RRASS  DIE    G
Sbjct: 226 SPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGF--G 283

Query: 295 VLPPP---PRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLAS 351
           V P      RHAS G  + ++S LL STSDS+L +Y TI+KIPQ+TLNF ++K +   +S
Sbjct: 284 VHPKNIFRDRHASEGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSS 343

Query: 352 P-TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVW 410
           P +SD+ IIAPK+K+RTHNVTEKVTQVLSLGADVLPEYKLQ PRI+++TILHYSPFKAVW
Sbjct: 344 PPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVW 403

Query: 411 DWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILIN 470
           DWLILLLVIYTA+FTPYSAAFLL + EE     ECGY+C PL VVDLIVDIMFI+DILIN
Sbjct: 404 DWLILLLVIYTAIFTPYSAAFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMFIIDILIN 462

Query: 471 FRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTA 527
           FRTTYVN NEEVVS P +IA+HYFKGWFLIDMVAAIPFDLLIFGSGS+E   LIGLLKTA
Sbjct: 463 FRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTA 522

Query: 528 RLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLH 587
           RLLRLVRVARKLDRYSEYGAAVL LLMC FALIAHWLACIWYAIGN+E+P++  +IGWL 
Sbjct: 523 RLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLD 582

Query: 588 NLGDQIGKPYNSS-GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646
           +LG QIGK YN S    GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML
Sbjct: 583 SLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 642

Query: 647 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 706
           IGSLMYASIFGNVSAIIQRLYSGTARYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+
Sbjct: 643 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 702

Query: 707 YTNGIDMNAV 716
           YTNGIDMN V
Sbjct: 703 YTNGIDMNMV 712


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
            isoform 1 [Homo sapiens]
          Length = 994

 Score =  926 bits (2393), Expect = 0.0
 Identities = 532/868 (61%), Positives = 605/868 (69%), Gaps = 89/868 (10%)

Query: 326  RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384
            +YRTIS+IPQ TLNFV+   +   +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 174  KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

Query: 385  LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
            LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E      
Sbjct: 234  LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292

Query: 445  CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
            C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 293  CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352

Query: 505  AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561
            AIPFDLLIF +GS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 353  AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412

Query: 562  HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFS 620
            HWLACIWYAIGN+E+P+++ +IGWL +LG Q+GK YN S    GPS++DKYVTALYFTFS
Sbjct: 413  HWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFS 472

Query: 621  SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
            SLTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV
Sbjct: 473  SLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 532

Query: 681  REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
            +EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC
Sbjct: 533  KEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHC 592

Query: 741  KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
              F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILG
Sbjct: 593  PAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILG 652

Query: 801  KNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITF 860
            KNDIFGEP++L+A+PGKS+ DVRALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TF
Sbjct: 653  KNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTF 712

Query: 861  NLRDT-----NMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEV---------S 906
            NLRD      +    +PGS + +G F             +D  +  P E+         S
Sbjct: 713  NLRDAAGGLHSSPRQAPGSQDHQGFF------------LSDNQSGSPHELGPQFPSKGYS 760

Query: 907  ALGPG---RAGAGPSSRGRPGG--PWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSP 961
             LGPG     GAGP + G P    P   S +SG   PE  ++           + P  SP
Sbjct: 761  LLGPGSQNSMGAGPCAPGHPDAAPPLSISDASG-LWPELLQE-----------MPPRHSP 808

Query: 962  RPPGEPPGGEPLM--EDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPT 1019
            + P E P   PL      E+     N L    S  S++      SR  Q  + P      
Sbjct: 809  QSPQEDPDCWPLKLGSRLEQLQAQMNRLESRVS--SDL------SRILQLLQKPMPQGHA 860

Query: 1020 PSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYS 1079
              +L  P S+         +  L  +  +      RL        Q          P+Y 
Sbjct: 861  SYILEAPASN---------DLALVPIASETTSPGPRLPQGFLPPAQ---------TPSYG 902

Query: 1080 AVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL--PPGAPELPQE------G 1131
             +    P   ++SP +P   L   T  +L+  S+    E L  P  +P  P E      G
Sbjct: 903  DLDDCSPKHRNSSPRMP--HLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 960

Query: 1132 PTRRLSLPGQLGALTSQ-PLHRHGSDPG 1158
            P    SLP  LG++  Q    RHGSDPG
Sbjct: 961  PCFS-SLPEHLGSVPKQLDFQRHGSDPG 987



 Score =  224 bits (570), Expect = 5e-58
 Identities = 106/130 (81%), Positives = 117/130 (90%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T   A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFE 130
           AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  813 bits (2099), Expect = 0.0
 Identities = 422/565 (74%), Positives = 456/565 (80%), Gaps = 62/565 (10%)

Query: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384
           +YRTIS+IPQ TLNFV+   +   +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

Query: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
           LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E      
Sbjct: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292

Query: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
           C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352

Query: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561
           AIPFDLLIF +GS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412

Query: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSS 621
           HWLACI                                                     S
Sbjct: 413 HWLACI----------------------------------------------------CS 420

Query: 622 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVR 681
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+
Sbjct: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480

Query: 682 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCK 741
           EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC 
Sbjct: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540

Query: 742 PFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGK 801
            F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGK
Sbjct: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600

Query: 802 NDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFN 861
           NDIFGEP++L+A+PGKS+ DVRALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFN
Sbjct: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660

Query: 862 LRDT-----NMIPGSPGSTELEGGF 881
           LRD      +    +PGS + +G F
Sbjct: 661 LRDAAGGLHSSPRQAPGSQDHQGFF 685



 Score =  224 bits (570), Expect = 5e-58
 Identities = 106/130 (81%), Positives = 117/130 (90%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T   A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFE 130
           AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 79/250 (31%), Positives = 103/250 (41%), Gaps = 71/250 (28%)

Query: 959  SSPRP-PGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPA 1017
            SSPR  PG        + D    SD   PLS     +S+    W +      QE+P   +
Sbjct: 670  SSPRQAPGSQDHQGFFLSD--NQSDAAPPLS-----ISDASGLWPEL----LQEMPPRHS 718

Query: 1018 PTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQM------ 1071
            P       P   P   P   + SRL+ LQ Q+NRLE+R+S+D++ +LQLLQ+ M      
Sbjct: 719  PQS-----PQEDPDCWPL-KLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHAS 772

Query: 1072 -----------TLVPPAYSAVTTPGP-------GPTST----------------SPLLPV 1097
                        LVP A S  T+PGP        P  T                SP +P 
Sbjct: 773  YILEAPASNDLALVPIA-SETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMP- 830

Query: 1098 SPLPTLTLDSLSQVSQFMACEEL--PPGAPELPQE------GPTRRLSLPGQLGALTSQ- 1148
              L   T  +L+  S+    E L  P  +P  P E      GP    SLP  LG++  Q 
Sbjct: 831  -HLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFS-SLPEHLGSVPKQL 888

Query: 1149 PLHRHGSDPG 1158
               RHGSDPG
Sbjct: 889  DFQRHGSDPG 898


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
            [Homo sapiens]
          Length = 1017

 Score =  478 bits (1231), Expect = e-134
 Identities = 316/800 (39%), Positives = 437/800 (54%), Gaps = 77/800 (9%)

Query: 385  LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
            +PEYK+ +    R  +LHYS  KA+WD LILL   Y AV  PY+  F     ++  P T 
Sbjct: 204  VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260

Query: 445  CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
                 +   V D+ V+++FI+DI++NFRTTYV+ + +V+S P  I +HY   WF ID++A
Sbjct: 261  -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315

Query: 505  AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 563
            A+PFDLL IF      L+ LLKT RLLRL+R+ +KL+RYS+  A VL LLM  FAL+AHW
Sbjct: 316  ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375

Query: 564  LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 620
            +ACIWY IG  E    D     IGWLH LG ++  PY +  +GGPS +  Y+ ALYFT S
Sbjct: 376  MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435

Query: 621  SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
            SLTSVGFGNV  NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS  + YH++M  +
Sbjct: 436  SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495

Query: 681  REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
            ++FIR H++P PL+QR+ EYFQ  W+  +GID N +L+ FP+ L+ADI +HLNR +LQ  
Sbjct: 496  KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554

Query: 741  KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
              F  A++GCLRAL++  KT+   PG+ L+  GD L A Y++  GS+E+LR ++V+AILG
Sbjct: 555  PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614

Query: 801  KNDIFGEPL-------NLYARPG---KSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSD 850
            K D+ G  +        L A P    K++ DV+ALTYC L ++    L EVL +YPE+  
Sbjct: 615  KGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGA 674

Query: 851  HFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSR-QRKRKLSFRRRTDKDTEQPGEVSA 907
             F + L  ++TFNLR      GS  S     G SR  R  +LS  R     +     + +
Sbjct: 675  AFRAGLPRDLTFNLRQ-----GSDTS-----GLSRFSRSPRLSQPRSESLGSSSDKTLPS 724

Query: 908  LGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESS-----EDEGPGRS---SSPLRLVPFS 959
            +    +GA P    RP  P    P+  P+ P  S      +E P  S   SSP  L P  
Sbjct: 725  ITEAESGAEPGGGPRPRRPL-LLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSL 782

Query: 960  SPRPPGE----PPGGEPLMEDCEKSSDTCNPLSGAF----------SGVSNIFSFWGDSR 1005
            SP   G+     P G P      K      P  G F           G+ +  S   ++ 
Sbjct: 783  SPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGS-TAEAP 841

Query: 1006 GRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQ 1065
              ++   P  P P            G RP  ++ S  + ++ ++ RL   +S     V Q
Sbjct: 842  SFRFSRRPELPRPRSQ-----APPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQ 896

Query: 1066 LLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAP 1125
             L R++  +     A   P PG  + S   P  P P L    LS       C   PP  P
Sbjct: 897  -LSRELRHIMGLLQARLGP-PGHPAGSAWTPDPPCPQLRPPCLS------PCASRPP--P 946

Query: 1126 ELPQEGPTRRLSLPGQLGAL 1145
             L Q+     +  P  +G +
Sbjct: 947  SL-QDTTLAEVHCPASVGTM 965



 Score =  154 bits (389), Expect = 5e-37
 Identities = 74/155 (47%), Positives = 104/155 (67%), Gaps = 11/155 (7%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANAR-VENCAVIYCNDGFCELCGYSRAEV 59
           MPV +G +APQNTFLDTI  +F+G    F++ANA+      ++YC+DGFCEL GY R EV
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQ+ C+C FL+GP T   A  ++ +AL G +E + EI FYRKDGS F CL+D++P+KNE 
Sbjct: 61  MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120

Query: 120 GAVIMFILNFEVVMEKDMVGSPA-------HDTNH 147
           G V++F+ +F+ + +    GSP         D+NH
Sbjct: 121 GEVVLFLFSFKDITQS---GSPGLGPQGGRGDSNH 152


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
            [Homo sapiens]
          Length = 1107

 Score =  477 bits (1228), Expect = e-134
 Identities = 291/738 (39%), Positives = 419/738 (56%), Gaps = 52/738 (7%)

Query: 373  KVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFL 432
            K+   + +     PEYK+   +  ++ +LH+S FKA WDWLILL   Y AV  PY+  F+
Sbjct: 187  KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246

Query: 433  LKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVH 492
              +      +T          V D+ V+I+FI+DI++NFRTTYV+ + +V+     I +H
Sbjct: 247  GNDDLSTTRST---------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297

Query: 493  YFKGWFLIDMVAAIPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 551
            Y   WF+ID++AA+PFDLL  F      L+ LLKT RLLRL+R+ +KLDRYS++   VL 
Sbjct: 298  YVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLT 357

Query: 552  LLMCTFALIAHWLACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSI 607
            LLM  FAL+AHW+ACIWY IG ME+     +   +GWLH LG ++  PY  ++ LGGPSI
Sbjct: 358  LLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSI 417

Query: 608  KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLY 667
            +  Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+Y
Sbjct: 418  RSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMY 477

Query: 668  SGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 727
            S  + YHT+   +++FIR H +P  L+QR+ EYFQ  WS  NGID N +LK FP+ L++D
Sbjct: 478  SRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537

Query: 728  ICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSI 787
            I +HLN+ +LQ    F  A++GCLR+L++  KT+   PG+ L+  GD L A+YF+  GS+
Sbjct: 538  ITMHLNKEILQ-LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSM 596

Query: 788  EILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
            E+L+  +V+AILGK D+ G  L++  +  K+N DV+ALTYCDL  I    L EVLD+YPE
Sbjct: 597  EVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPE 656

Query: 848  FSDHFWSSL--EITFNLRD-------TNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKD 898
            ++  F   +  ++T+NLR+       + +   S  S     G     KR  S     +++
Sbjct: 657  YAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEE 716

Query: 899  TEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPF 958
             E   E +         G SSR +  G        G S  + +    P    SP+R+   
Sbjct: 717  EEGEEEEAVSLSPICTRGSSSRNKKVG--SNKAYLGLSLKQLASGTVP--FHSPIRVSRS 772

Query: 959  SSPRPPGE--PPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCP 1016
            +SP+   E  PP      E   K   +    +G       I    G   G   +E     
Sbjct: 773  NSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVD--GIEDGNSSEESQTFD 830

Query: 1017 APTPSLLNIPLSSPGRRPRGDVE-------SRLDALQRQLNRLE----------TRLSAD 1059
              +  + + P  SP   P GD E        + +  ++Q+N+L           ++L  D
Sbjct: 831  FGSERIRSEPRISP---PLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKD 887

Query: 1060 MATVLQLLQRQMTLVPPA 1077
            M  V+QLL+  ++   P+
Sbjct: 888  MRNVIQLLENVLSPQQPS 905



 Score =  144 bits (362), Expect = 6e-34
 Identities = 68/142 (47%), Positives = 99/142 (69%), Gaps = 1/142 (0%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARV-ENCAVIYCNDGFCELCGYSRAEV 59
           MPV +G +APQNTFLDTI  +F+G    FI+ANA+V +   ++YC+DGFCEL G++R EV
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQ+ C+C FL G  T  +   QI ++L    E K EI FY+K+GS F CL+D+VP+KNE 
Sbjct: 61  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120

Query: 120 GAVIMFILNFEVVMEKDMVGSP 141
           G V++F+ +F+ + +  +  +P
Sbjct: 121 GDVVLFLASFKDITDTKVKITP 142


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  471 bits (1213), Expect = e-132
 Identities = 243/530 (45%), Positives = 344/530 (64%), Gaps = 32/530 (6%)

Query: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217

Query: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265

Query: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGL 523
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   
Sbjct: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSS 325

Query: 524 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 583
           LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E    D++ 
Sbjct: 326 LKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKT 385

Query: 584 ----GWLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPN 633
                WL+ L   IG PY  +G G      GPS    Y+++LYFT +SLTSVGFGN++P+
Sbjct: 386 IRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPS 445

Query: 634 TNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPL 693
           T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L
Sbjct: 446 TDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGL 505

Query: 694 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRA 753
            +R+ +Y    WS + GID   VL+  P+ ++ADIC+HLNR + +    FR A+ GCLRA
Sbjct: 506 SERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRA 565

Query: 754 LAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYA 813
           LAM+F+T H  PGD + HAG+ + +L F+  GS+E+++ D VVAILGK D+FG+     A
Sbjct: 566 LAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEA 625

Query: 814 RPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 863
              +S  +VRALTYCDLH I RD L +VL+ Y  FS  F  +L +T+NLR
Sbjct: 626 TLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFILNF 129
           +F+  F
Sbjct: 125 LFLCTF 130


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  463 bits (1191), Expect = e-130
 Identities = 237/528 (44%), Positives = 339/528 (64%), Gaps = 25/528 (4%)

Query: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 156 LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 215

Query: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 263

Query: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 264 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 323

Query: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 324 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 383

Query: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 384 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443

Query: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

Query: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563

Query: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARP 815
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILGK D+FG+        
Sbjct: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTL 623

Query: 816 GKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 863
             +  +VRALTYCDLH I R+ LL+VLD Y  F++ F  +L +T NLR
Sbjct: 624 AHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 671



 Score =  103 bits (258), Expect = 7e-22
 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           +RG VAPQNTFL+ I+R+    S  F++ NA++ +  V+Y NDGFC+L GY RA+VMQ+ 
Sbjct: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE   V+
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFILNFEVVMEKDMVGSPAHDTNHRG 149
           +F+  F+ +    +   P  D + +G
Sbjct: 123 LFLCTFKDI---TLFKQPIEDDSTKG 145


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  463 bits (1191), Expect = e-130
 Identities = 237/528 (44%), Positives = 339/528 (64%), Gaps = 25/528 (4%)

Query: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 98  LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 157

Query: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 158 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 205

Query: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 206 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 265

Query: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 266 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 325

Query: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 326 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 385

Query: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 386 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 445

Query: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 446 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 505

Query: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARP 815
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILGK D+FG+        
Sbjct: 506 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTL 565

Query: 816 GKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 863
             +  +VRALTYCDLH I R+ LL+VLD Y  F++ F  +L +T NLR
Sbjct: 566 AHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 613



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQ+  TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE 
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRG 149
             V++F+  F+ +    +   P  D + +G
Sbjct: 61  EKVVLFLCTFKDI---TLFKQPIEDDSTKG 87


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  461 bits (1186), Expect = e-129
 Identities = 243/557 (43%), Positives = 344/557 (61%), Gaps = 59/557 (10%)

Query: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217

Query: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265

Query: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF-------------- 513
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++                
Sbjct: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDP 325

Query: 514 -----------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCT 556
                              G   L   LK  RLLRL RVARKLD Y EYGAAVL LL+C 
Sbjct: 326 GKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCV 385

Query: 557 FALIAHWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPS 606
           F L AHW+ACIWY+IG+ E    D++      WL+ L   IG PY  +G G      GPS
Sbjct: 386 FGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPS 445

Query: 607 IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 666
               Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++
Sbjct: 446 KNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQM 505

Query: 667 YSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQA 726
           Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++A
Sbjct: 506 YANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRA 565

Query: 727 DICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGS 786
           DIC+HLNR + +    FR A+ GCLRALAM+F+T H  PGD + HAG+ + +L F+  GS
Sbjct: 566 DICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGS 625

Query: 787 IEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 846
           +E+++ D VVAILGK D+FG+     A   +S  +VRALTYCDLH I RD L +VL+ Y 
Sbjct: 626 LEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYT 685

Query: 847 EFSDHFWSSLEITFNLR 863
            FS  F  +L +T+NLR
Sbjct: 686 AFSHSFSRNLILTYNLR 702



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFILNF 129
           +F+  F
Sbjct: 125 LFLCTF 130


>gi|38569493 potassium voltage-gated channel, subfamily H
            (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  448 bits (1153), Expect = e-125
 Identities = 300/782 (38%), Positives = 408/782 (52%), Gaps = 119/782 (15%)

Query: 385  LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
            LPEYK+ A R   + +LH    +A WD  ILL  +Y AV  PYS             A E
Sbjct: 202  LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253

Query: 445  CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
               A  P +V DL V+++FI+DI++NFRTT+V+ + +VV  P  I +HY   WFL+D++A
Sbjct: 254  PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313

Query: 505  AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 557
            A+PFDLL        FG+       LLKT RLLRL+R+  +LDRYS+Y A VL LLM  F
Sbjct: 314  ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367

Query: 558  ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 601
            AL+AHW+AC+W+ IG  E    +S    IGWL  L  ++  PY          NSSG   
Sbjct: 368  ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427

Query: 602  ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646
                           LGGPS++  Y+T+LYF  SSLTSVGFGNVS NT++EKIFSIC ML
Sbjct: 428  NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487

Query: 647  IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 706
            IG+LM+A +FGNV+AIIQR+Y+    YH++   +R++IR H+IP PL+QR+ EYFQ  W+
Sbjct: 488  IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547

Query: 707  YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 766
              NGID   +L+  P+ L+ADI +HL++ +LQ    F  A++GCLRAL++  +     PG
Sbjct: 548  VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606

Query: 767  DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALT 826
            + L+H GD L ALYF+  GS+E+L+G  V+AILGK D+ G  L    +  K+N DV+ LT
Sbjct: 607  EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLT 666

Query: 827  YCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSRQ 884
            YC L  +    L + L +YPEF+  F   L  E+++NL          GS E++      
Sbjct: 667  YCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL------GAGGGSAEVDTSSLSG 720

Query: 885  RKRKLSFRRRTDKDTEQ------------------PGEVSA------LGPGRAGAGP--S 918
                +S     + D EQ                  PG  S+      L P R    P   
Sbjct: 721  DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780

Query: 919  SRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCE 978
             RGRPG        +GPS+P         R+   LRL P     PP   P    +++  E
Sbjct: 781  GRGRPGRAGALKAEAGPSAPP--------RALEGLRLPPMPWNVPPDLSP---RVVDGIE 829

Query: 979  KSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDV 1038
                +  P           FSF     G +    P  P P   LL +P   P      D 
Sbjct: 830  DGCGSDQPK----------FSFRVGQSGPECSSSP-SPGPESGLLTVP-HGPSEARNTDT 877

Query: 1039 ESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTP-----GPGPTSTSP 1093
               LD L++ +  L  ++   M   LQ L++ + LV   +     P     GP P STS 
Sbjct: 878  ---LDKLRQAVTELSEQV-LQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSG 933

Query: 1094 LL 1095
            LL
Sbjct: 934  LL 935



 Score =  146 bits (369), Expect = 1e-34
 Identities = 74/159 (46%), Positives = 98/159 (61%), Gaps = 11/159 (6%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENC-AVIYCNDGFCELCGYSRAEV 59
           MP  RG +APQNTFLDTI  +F+G    F++ NA+V     V+YC+DGFC+L G+SRAEV
Sbjct: 1   MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQR C C FL+GP T      QI +AL   +E K E+  YRK G  F CL+DV+P+KNE 
Sbjct: 61  MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120

Query: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPG 158
           G V +F+++ + + E          T +RG P  W   G
Sbjct: 121 GEVALFLVSHKDISE----------TKNRGGPDRWKETG 149


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  409 bits (1052), Expect = e-114
 Identities = 207/464 (44%), Positives = 299/464 (64%), Gaps = 25/464 (5%)

Query: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 156 LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 215

Query: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 263

Query: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 264 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 323

Query: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 324 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 383

Query: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 384 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443

Query: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

Query: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563

Query: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAIL 799
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAIL
Sbjct: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607



 Score =  103 bits (258), Expect = 7e-22
 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           +RG VAPQNTFL+ I+R+    S  F++ NA++ +  V+Y NDGFC+L GY RA+VMQ+ 
Sbjct: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE   V+
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFILNFEVVMEKDMVGSPAHDTNHRG 149
           +F+  F+ +    +   P  D + +G
Sbjct: 123 LFLCTFKDI---TLFKQPIEDDSTKG 145


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
            potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  175 bits (443), Expect = 3e-43
 Identities = 176/783 (22%), Positives = 318/783 (40%), Gaps = 107/783 (13%)

Query: 398  WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
            W I  YS F+  WD ++L++++   V  P    F  ++T              P  + ++
Sbjct: 133  WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTT------------PWIIFNV 180

Query: 458  IVDIMFIVDILINFRTTYVNANE-EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 513
              D +F++D+++NFRT  VN +  E++  P  I ++Y K WF++D +++IP D +     
Sbjct: 181  ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE 240

Query: 514  -GSGSE--------------ELIGLLKTARLLRLVRVARKLDR-----YSEYGAAV-LFL 552
             G  SE              +++ LL+  RL RL+R   + +      Y    A V +F 
Sbjct: 241  KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN 300

Query: 553  LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
            L+    L+ HW  C+ + +  ++    D  +     + D  GK Y+              
Sbjct: 301  LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSY------------- 347

Query: 613  TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
             AL+   S +  +G+G  +P + S+   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 348  -ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQ 406

Query: 673  YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
            Y  +  +V +++ FH++P  +RQ++ +Y++H +      D   +L    + L+ +I    
Sbjct: 407  YQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFN 465

Query: 733  NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
             R L+     F  A    + A+  K +     PGD ++  G +   +YFI  G   ++  
Sbjct: 466  CRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK 525

Query: 793  DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 852
                  L     FGE   L    G+    VRA TYC L+ +  D+  EVL+ YP     F
Sbjct: 526  SSKEMKLTDGSYFGEICLL--TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 583

Query: 853  WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQP------GE 904
             + +++    +   N I       +L  G F+ Q    L    + D++  Q        +
Sbjct: 584  ETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQ 643

Query: 905  VSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPP 964
            ++ L    +   P+SR R   P                   P  +++ L      SP P 
Sbjct: 644  MTTLNSTSSTTTPTSRMRTQSP-------------------PVYTATSLSHSNLHSPSPS 684

Query: 965  GEPPGGEPLMEDCEKSSDTCNP------LSGAF---SGVSNIFSFWGDSRGRQYQE---- 1011
             + P    ++  C  ++  C+P       +  F   S  ++  S       +Q Q+    
Sbjct: 685  TQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPP 744

Query: 1012 --LPRCPAPTPSLLNIPLSSPG-RRPRGDVESRLDALQR-QLNRLETRLSADMATVLQLL 1067
               P+ P+P P        +PG   P+ +V     AL    L R    LSA   ++   +
Sbjct: 745  QTQPQQPSPQP-------QTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEV 797

Query: 1068 QRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPP--GAP 1125
               ++   P         P P +  P   +      T+     + + M+   +PP  G P
Sbjct: 798  STLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVP 857

Query: 1126 ELP 1128
              P
Sbjct: 858  PAP 860


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  174 bits (442), Expect = 3e-43
 Identities = 124/474 (26%), Positives = 214/474 (45%), Gaps = 54/474 (11%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD  +LLL++   +  P    F   E               P  V ++
Sbjct: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300

Query: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516
           + D  F++D+++NFRT   V  N E++  P RI + Y K WF++D +++IP D +     
Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360

Query: 517 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 552
           +     + KTAR LR+VR  +        +L R   Y               +AV+ +  
Sbjct: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420

Query: 553 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
           L+    L+ HW  C+ + +  ++    D  +   + + +  GK Y+              
Sbjct: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467

Query: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
            AL+   S +  +G+G  +P   S+   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526

Query: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
           Y  +  +V +++ FH++P   RQR+ +Y++H +      D  ++L    E L+ +I    
Sbjct: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585

Query: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
            R L+     F  A    + ++  K +     PGD ++  G +   +YFI  G + +L  
Sbjct: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645

Query: 793 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 846
                 L     FGE + L  R G+    VRA TYC L+ +  D+  EVL+ YP
Sbjct: 646 GNKETKLADGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYP 697



 Score = 35.0 bits (79), Expect = 0.41
 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 22/102 (21%)

Query: 903 GEVSALGPGRAGAGPSSRGRPGGPWGESP------SSGPSSPE--------SSEDEGPGR 948
           G +++LG    G+G +  G   G   +S       + G +SP         ++E E PG 
Sbjct: 98  GSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGA 157

Query: 949 SSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSS-DTCNPLSG 989
           S+ P      +SP PP +PP  +P    CE+ S DT   + G
Sbjct: 158 SAQPA-----ASPPPPQQPP--QPASASCEQPSVDTAIKVEG 192


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  173 bits (438), Expect = 1e-42
 Identities = 161/659 (24%), Positives = 271/659 (41%), Gaps = 103/659 (15%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD+ +LL ++   +  P    F   ET              P  V ++
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249

Query: 458 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 513
           + D  F++D+++NFRT  V   N E++  P +I   Y + WF++D V++IP D +     
Sbjct: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309

Query: 514 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 556
            G  SE               +L   RLLRL R+ R + ++ E     Y  A   + +C 
Sbjct: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369

Query: 557 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
                 L+ HW  C+ + +  ++      R  W+           + +G+   S  + Y 
Sbjct: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415

Query: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
            AL+   S +  +G+G  +P + ++   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475

Query: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
           Y  +  +V +++ FH++P   RQ++ +Y++H +      D +++L      L+ +I    
Sbjct: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534

Query: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
            R L+     F  A    + A+  K K     PGD ++  G +   +YFI  G + +L  
Sbjct: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 594

Query: 793 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 852
                 L     FGE + L  R G+    VRA TYC L+ +  D+  EVL+ YP     F
Sbjct: 595 GNKEMKLSDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652

Query: 853 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQPGEVS---- 906
            + +++    +   N I       +L  G F+ Q    +    + D++  Q  E+     
Sbjct: 653 ETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVG 712

Query: 907 ---------------------------------ALGPGRAGAGPSSRGRPGGPWGESPSS 933
                                             +GP   G+    R  P GP   + S 
Sbjct: 713 LFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASP 772

Query: 934 GPSSPESSEDEGPGRSSSPLRLVPFSSPRP--PGEPPGGEPLMEDCEKSSDTCNPLSGA 990
           GP  P S     PG  +SP    P +SP    P  P  G  L     + S    PLS +
Sbjct: 773 GPPPPASP----PGAPASP--RAPRTSPYGGLPAAPLAGPAL--PARRLSRASRPLSAS 823



 Score = 31.6 bits (70), Expect = 4.6
 Identities = 21/65 (32%), Positives = 24/65 (36%), Gaps = 9/65 (13%)

Query: 909 GPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPP 968
           G GR G  P +   PG P    P   P+ P+      P     P    P   P PP  PP
Sbjct: 6   GGGRPGESPGATPAPGPP----PPPPPAPPQQQPPPPP-----PPAPPPGPGPAPPQHPP 56

Query: 969 GGEPL 973
             E L
Sbjct: 57  RAEAL 61



 Score = 31.2 bits (69), Expect = 6.0
 Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 13/75 (17%)

Query: 910 PGRAGAGPSSRGRPGGPWGE-SPSSGPSSPES------------SEDEGPGRSSSPLRLV 956
           PG  GA  +++G P G  G   P   P+ PE                 GP     P    
Sbjct: 85  PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEA 144

Query: 957 PFSSPRPPGEPPGGE 971
                 P GEP G +
Sbjct: 145 GSEEAGPAGEPRGSQ 159


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  171 bits (434), Expect = 3e-42
 Identities = 127/476 (26%), Positives = 213/476 (44%), Gaps = 56/476 (11%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD ++LLL++   +  P    F     EE  P         P  V ++
Sbjct: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131

Query: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516
           + D  F++D+++NFRT   V    E++  P  I   Y + WFL+D++++IP D +     
Sbjct: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191

Query: 517 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 550
            E  +   + KTAR LR+VR  +        +L R   Y               +AV  +
Sbjct: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251

Query: 551 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 610
           F L+    L+ HW  C+ + +  ++    D  +   H +    G+ Y+            
Sbjct: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300

Query: 611 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 670
              AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357

Query: 671 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 730
            +Y  +  +V +++ FH++P   RQR+ EY++H +      D  ++L    E L+ +I  
Sbjct: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416

Query: 731 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790
              R L+ H   F  A    + A+  K +     PGD +V  G +   +YFI  G + +L
Sbjct: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476

Query: 791 RGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 846
                   L     FGE + L  R G+    VRA TYC L+ +  D    VL+ +P
Sbjct: 477 ARGARDTRLTDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDHFNAVLEEFP 530


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  157 bits (398), Expect = 4e-38
 Identities = 110/410 (26%), Positives = 203/410 (49%), Gaps = 37/410 (9%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245

Query: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
              G+      ++  RLL+  R+    DR             G  VL++L     +I HW
Sbjct: 246 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 298

Query: 564 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 623
            ACI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT
Sbjct: 299 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 346

Query: 624 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 683
           ++G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++
Sbjct: 347 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405

Query: 684 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 743
           ++F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F
Sbjct: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465

Query: 744 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGK 801
           +    G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L  
Sbjct: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525

Query: 802 NDIFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
              FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  157 bits (398), Expect = 4e-38
 Identities = 110/410 (26%), Positives = 203/410 (49%), Gaps = 37/410 (9%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263

Query: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
              G+      ++  RLL+  R+    DR             G  VL++L     +I HW
Sbjct: 264 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 316

Query: 564 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 623
            ACI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT
Sbjct: 317 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 364

Query: 624 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 683
           ++G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++
Sbjct: 365 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423

Query: 684 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 743
           ++F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F
Sbjct: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 483

Query: 744 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGK 801
           +    G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L  
Sbjct: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543

Query: 802 NDIFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
              FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  148 bits (373), Expect = 3e-35
 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 513
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330

Query: 514 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 571
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390

Query: 572 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 631
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437

Query: 632 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 691
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497

Query: 692 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 751
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557

Query: 752 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 809
             L +K +     PGD +   GD+   +Y I  G + ++  D V    +L     FGE  
Sbjct: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617

Query: 810 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
            L  +  K+      +++++ Y DL  + +DDL+E L  YP+
Sbjct: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 659


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  148 bits (373), Expect = 3e-35
 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 513
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 202 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 261

Query: 514 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 571
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 262 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 321

Query: 572 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 631
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 322 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 368

Query: 632 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 691
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 369 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 428

Query: 692 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 751
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 429 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 488

Query: 752 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 809
             L +K +     PGD +   GD+   +Y I  G + ++  D V    +L     FGE  
Sbjct: 489 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 548

Query: 810 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
            L  +  K+      +++++ Y DL  + +DDL+E L  YP+
Sbjct: 549 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 590


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  140 bits (352), Expect = 9e-33
 Identities = 107/418 (25%), Positives = 194/418 (46%), Gaps = 53/418 (12%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 512
           V+D + D+++I D+ I  RT ++     +V    ++  +Y     F +D+ + IP DL+ 
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235

Query: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
           F          ++  RLL   R+    DR                VL++L+     I HW
Sbjct: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288

Query: 564 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKD--------KYVTAL 615
            ACI+YAI       +D+   W++                 P+I D        +Y+  L
Sbjct: 289 NACIYYAISKSIGFGVDT---WVY-----------------PNITDPEYGYLAREYIYCL 328

Query: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
           Y++  +LT++G     P  + E +F I   LIG L++A+I GNV ++I  + +  A +  
Sbjct: 329 YWSTLTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQA 387

Query: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
           ++  V+ +++F ++   +  ++  +F + W+    +D   +LK  P  L+A+I ++++ S
Sbjct: 388 KIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLS 447

Query: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
            L+  + F     G L  L +K +     PGD +   GD+   +Y I  G + ++  D V
Sbjct: 448 TLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGV 507

Query: 796 V--AILGKNDIFGEPLNLYARPGK----SNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
              A+L     FGE   L  +  K       ++R+L Y DL  + +DDL+E +  YP+
Sbjct: 508 TQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  133 bits (335), Expect = 9e-31
 Identities = 100/419 (23%), Positives = 201/419 (47%), Gaps = 30/419 (7%)

Query: 441 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 499
           P  + GY    L V+D   D+++++D+++ F T ++     VV   GRI+  Y + W F 
Sbjct: 59  PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116

Query: 500 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 555
           +D+ + +P D++    G       L+  R LR  R+    DR         A  +  LM 
Sbjct: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174

Query: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615
              ++ HW +C+++A+        D+   W++          + +  G   ++ +Y+ + 
Sbjct: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222

Query: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
           YF+   LT+VG     P    E +F +   L+  + +A+I G++S++I  + +  A ++ 
Sbjct: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281

Query: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
               V+++++   +   L +R+ +++QH        +  A+L+  PE L+A++ + ++ S
Sbjct: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341

Query: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
            L   + F+      L  L +K +     PG+ +   GD+   +Y I  G + ++  D +
Sbjct: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401

Query: 796 V--AILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE 847
              A+LG    FGE +++    G  +G     ++++L Y DL  + ++DL EVL  YP+
Sbjct: 402 TQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 106/511 (20%), Positives = 208/511 (40%), Gaps = 50/511 (9%)

Query: 350 ASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLP--EY--KLQAPR-IHRWTILHYS 404
           ASP + +    P +KE     TE   ++L      +P  EY  +++ P  I  +T   Y 
Sbjct: 160 ASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLY- 218

Query: 405 PFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFI 464
               +W  L+ L   +   F P    F  +  +                + D+I DI+++
Sbjct: 219 ---LLWLLLVTLAYNWNCCFIPLRLVFPYQTADN----------IHYWLIADIICDIIYL 265

Query: 465 VDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLIFGSGSEELIG 522
            D+L I  R  +V   + +V     +  HY     F +D+ + IPFD+     G   +  
Sbjct: 266 YDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFR 324

Query: 523 LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNMEQPHMDS 581
             +  +          L+   +       +    + L I H  AC++Y   N E      
Sbjct: 325 ANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGI---G 381

Query: 582 RIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFS 641
              W+          Y+  G       ++Y+   Y+   +L ++G G   P T  E +F 
Sbjct: 382 TTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQ 423

Query: 642 ICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYF 701
           +     G  +++S+ G +  +I    +    +   M     ++  + IP  +++R+  ++
Sbjct: 424 LLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWY 483

Query: 702 QHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTT 761
           ++ W     +D + +LK  P  +Q  + + +N S++     F+G     +  + ++ K+ 
Sbjct: 484 EYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSV 543

Query: 762 HAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIFGEPLNLYARPG-- 816
              PGD +   G++   +Y I  G +++L    G  V+  L    +FGE ++L A  G  
Sbjct: 544 LYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE-ISLLAAGGGN 602

Query: 817 KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
           +   +V A  + +L  + +  L E+L  YP+
Sbjct: 603 RRTANVVAHGFANLLTLDKKTLQEILVHYPD 633


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 80/404 (19%), Positives = 185/404 (45%), Gaps = 35/404 (8%)

Query: 454  VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 511
            ++D + D+++ +DI +   R  +V   + +++    +  +Y K   F +D+++ +P D L
Sbjct: 693  LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751

Query: 512  IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 568
                G   L+ L +  + +       +L+  S    A ++ ++ T A + + L   +C++
Sbjct: 752  YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809

Query: 569  YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 628
            Y     +       +G  H + D +G              + Y+   YF   +L ++G G
Sbjct: 810  YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848

Query: 629  NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 688
               P T  E +F +     G   ++ + G +  ++    +G   Y + M    +++ F++
Sbjct: 849  LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908

Query: 689  IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 748
            IP  ++ R++ ++++ W     +D + ++   P+ ++ D+ + +N +++     F+G  +
Sbjct: 909  IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968

Query: 749  GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIF 805
              +  +  + ++    P D +   G++   +Y I  G +++L    G  V+  L    +F
Sbjct: 969  QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028

Query: 806  GEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
            GE ++L A  G  +   +V A  + +L  + + DL E+L  YPE
Sbjct: 1029 GE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 61/222 (27%), Positives = 82/222 (36%), Gaps = 27/222 (12%)

Query: 932  SSGPSSPESSEDE-GPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGA 990
            SS P +P S  +   PG   SP  + P +SP     P    P+      S+ + +P S  
Sbjct: 804  SSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVS-SNPSPHPTSSP 862

Query: 991  FSGVSNIFSFWGDSRGRQYQELPRCPAPT--PSLLNIPLSSPGRRPRGDVESRLDALQRQ 1048
                S+   F        +  LP    PT  P+   + LSSP   P     S        
Sbjct: 863  LPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAP 922

Query: 1049 LNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTL--- 1105
            L  L +  S  + TV Q L               +P PG  S SP  P SPLP+L L   
Sbjct: 923  LLSLASAFSLAVMTVAQSL--------------LSPSPGLLSQSPPAPPSPLPSLPLPPP 968

Query: 1106 ------DSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQ 1141
                  +S S  +  +  E  PP A  LP E     +S  G+
Sbjct: 969  VAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGK 1010


>gi|5031767 heat shock transcription factor 1 [Homo sapiens]
          Length = 529

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 63/236 (26%), Positives = 92/236 (38%), Gaps = 33/236 (13%)

Query: 930  SPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEP------PGGEPLMEDCEKSSDT 983
            +P+S  +SP  S DE P  SSSPL  V    P PP  P      PG    ++     +  
Sbjct: 272  APASPMASPGGSIDERP-LSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTAL 330

Query: 984  CNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLD 1043
             + +           +   D+RG    E  R P+P P+       S     + ++   LD
Sbjct: 331  IDSILRESEPAPASVTALTDARGHTDTE-GRPPSPPPTSTPEKCLSVACLDKNELSDHLD 389

Query: 1044 ALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTL 1103
            A+   L+ L+T LS+                   +S  T+      S S  +P   LP L
Sbjct: 390  AMDSNLDNLQTMLSSH-----------------GFSVDTSALLDLFSPSVTVPDMSLPDL 432

Query: 1104 TLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 1159
               SL+ + + ++ +E PP  PE     P        QL   T+QPL     DPGS
Sbjct: 433  D-SSLASIQELLSPQE-PPRPPEAENSSP----DSGKQLVHYTAQPLFL--LDPGS 480


>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
          Length = 1142

 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 67/255 (26%), Positives = 97/255 (38%), Gaps = 56/255 (21%)

Query: 930  SPSSGPSS-PESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLM--EDCEKSSDTCNP 986
            +PSS P S PESS+    G   SPL     S   PP       PL   E   +  D+ +P
Sbjct: 636  TPSSLPQSFPESSQSPPEGPVQSPLH----SPQSPPEGMHSQSPLQSPESAPEGEDSLSP 691

Query: 987  LS---GAFSGVSNIFSF--------WGDS-----------RGRQYQELPRCPAP---TPS 1021
            L        G  ++ S         W DS           +G  +Q   + P     + +
Sbjct: 692  LQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSST 751

Query: 1022 LLNIPLS---SPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAY 1078
             L++P S   SP   P G  +S    LQR ++      S  +A++LQ           ++
Sbjct: 752  SLSLPQSFPESPQSPPEGPAQS---PLQRPVSSF---FSYTLASLLQ----------SSH 795

Query: 1079 SAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQ---VSQF--MACEELPPGAPELPQEGPT 1133
             +  +P  GP  +    PVS  P+ T  SLSQ   VS F       L   +PE P + P 
Sbjct: 796  ESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPV 855

Query: 1134 RRLSLPGQLGALTSQ 1148
               S    L   + +
Sbjct: 856  ISFSSSTSLSPFSEE 870



 Score = 31.2 bits (69), Expect = 6.0
 Identities = 46/203 (22%), Positives = 76/203 (37%), Gaps = 43/203 (21%)

Query: 936  SSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCN---------- 985
            SSPES++    G   SPL++        PG P     L+   + S +  +          
Sbjct: 356  SSPESAQSTFEGFPQSPLQI--------PGSPSFSSTLLSLFQSSPERTHSTFEGFPQSP 407

Query: 986  ---PLSGAFSG-VSNIFSFWGDSRGRQYQELPRCPAPTP-------SLLNIPLSSPGRRP 1034
               P++ +FS  + +I     +S    ++  P+ P   P       +LL++  SSP R  
Sbjct: 408  LQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSSFSYTLLSLFQSSPER-- 465

Query: 1035 RGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAV--------TTPGP 1086
                 S  +   +   ++    S+  +T+L L Q         +            +P  
Sbjct: 466  ---THSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEGFPQSPLQIPQSPPE 522

Query: 1087 GPTSTSPLLPVSPLPTLTLDSLS 1109
            G  + SPL  V  LP    DSLS
Sbjct: 523  GENTHSPLQIVPSLPEWE-DSLS 544


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,506,277
Number of Sequences: 37866
Number of extensions: 2897580
Number of successful extensions: 20490
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 654
Number of HSP's that attempted gapping in prelim test: 16900
Number of HSP's gapped (non-prelim): 3860
length of query: 1159
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1046
effective length of database: 13,968,660
effective search space: 14611218360
effective search space used: 14611218360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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