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Search of human proteins with 4557445
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
(551 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557445 regulator of chromosome condensation and BTB domain c... 1134 0.0
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 791 0.0
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 153 4e-37
gi|126032348 hect domain and RLD 2 [Homo sapiens] 151 2e-36
gi|7657152 hect domain and RLD 3 [Homo sapiens] 150 4e-36
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 149 8e-36
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 149 8e-36
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 139 9e-33
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 139 9e-33
gi|110825982 hect domain and RLD 5 [Homo sapiens] 134 2e-31
gi|61563742 hect domain and RLD 6 [Homo sapiens] 129 7e-30
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 120 2e-27
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 118 1e-26
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 118 1e-26
gi|6912330 deafness locus associated putative guanine nucleotide... 104 2e-22
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 102 9e-22
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 102 9e-22
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 101 2e-21
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 100 3e-21
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 99 1e-20
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 91 4e-18
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 91 4e-18
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 90 6e-18
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 90 6e-18
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 83 6e-16
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 83 6e-16
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 83 6e-16
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 83 6e-16
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 83 6e-16
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 83 6e-16
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 1134 bits (2934), Expect = 0.0
Identities = 551/551 (100%), Positives = 551/551 (100%)
Query: 1 MEEELPLFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLY 60
MEEELPLFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLY
Sbjct: 1 MEEELPLFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLY 60
Query: 61 TTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEV 120
TTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEV
Sbjct: 61 TTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEV 120
Query: 121 FTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNN 180
FTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNN
Sbjct: 121 FTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNN 180
Query: 181 SGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLG 240
SGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLG
Sbjct: 181 SGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLG 240
Query: 241 NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300
NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP
Sbjct: 241 NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300
Query: 301 TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACF 360
TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACF
Sbjct: 301 TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACF 360
Query: 361 ATPAVTWRLLSVEPDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR 420
ATPAVTWRLLSVEPDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR
Sbjct: 361 ATPAVTWRLLSVEPDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR 420
Query: 421 SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQ 480
SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQ
Sbjct: 421 SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQ 480
Query: 481 QTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFI 540
QTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFI
Sbjct: 481 QTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFI 540
Query: 541 SKASRVGAFKN 551
SKASRVGAFKN
Sbjct: 541 SKASRVGAFKN 551
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 791 bits (2043), Expect = 0.0
Identities = 374/531 (70%), Positives = 439/531 (82%), Gaps = 4/531 (0%)
Query: 25 MLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQ 84
M+DVGKWPIF+L S +E+ IR+ACVFG++ +E LY T NDE+FV G N CLG GD Q
Sbjct: 1 MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ 60
Query: 85 STIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCH 144
ST+ P++L+ L GKKI LSYGSGPH++L+T +G V+ WGHN YSQLGNGTTN G+ P
Sbjct: 61 STLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQ 120
Query: 145 ISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN 204
+ TNL KQV+EVACGS+HS+ L +DGEVFAWGYNN GQVGSGST NQP PR+VT CL
Sbjct: 121 VCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHI 180
Query: 205 KVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVAC 264
K VV IACGQ MAV+D GEVY WGYNGNGQLGLGN+GNQ TP RVAAL + V ++ C
Sbjct: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVC 240
Query: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAA 324
GYAHTL LTDEG +YAWGAN+YGQLGTGNK+N P + VEK+R++EIAACHS HTSAA
Sbjct: 241 GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 325 KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESL 384
KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAV+WRLLSVE +D LTVAESL
Sbjct: 301 KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESL 360
Query: 385 KREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED--NED--DIVEMSEFSYPV 440
K+EFD+P+TADLKF +DGKYI+ HK +LKIRCEHFRS + NED +++E+ +FSYPV
Sbjct: 361 KKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPV 420
Query: 441 YRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAV 500
YRAFL+YLYTD++ L PE+A+GLLDLAT Y ENRLKKLCQ IK+GI ENA +L SAAV
Sbjct: 421 YRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAV 480
Query: 501 KYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 551
+YDA+DLEEFCF+FCINHLT VTQT+ F +MD LLK FI+KAS+ GAFKN
Sbjct: 481 RYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN 531
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 153 bits (386), Expect = 4e-37
Identities = 98/289 (33%), Positives = 148/289 (51%), Gaps = 6/289 (2%)
Query: 64 NDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACL--SYGSGPHIVLATTEGEVF 121
N + G G LG G+ + +L G + L S GS H + T GEVF
Sbjct: 4045 NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 4104
Query: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
+WG Y +LG+G ++ P I L ++V++++CG HS V+TSDG++F +G +
Sbjct: 4105 SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163
Query: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAV-VDTGEVYVWGYNGNGQLGLG 240
G++G G+T N+ +P RVT L+ + +ACG +AV D V+ +G G+LGLG
Sbjct: 4164 GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 4222
Query: 241 NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300
NS + +P ++ L GI +++VACG ++ LT +G VY +G + L G N + P
Sbjct: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 4282
Query: 301 TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 349
+ V IIE A + HT A G VY WG + L H H
Sbjct: 4283 QQIPVLAGVIIEDVAVGAEHT-LALASNGDVYAWGSNSEGQLGLGHTNH 4330
Score = 145 bits (366), Expect = 9e-35
Identities = 92/276 (33%), Positives = 156/276 (56%), Gaps = 8/276 (2%)
Query: 52 GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHI 111
GS G+ + T + E+F G G LG G+ PR++++L G+++ +S G H
Sbjct: 4089 GSDGHSMALTE-SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHS 4146
Query: 112 VLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171
+ T++G++FT+G+ Y +LG G T++ +P + T L Q+ +VACG H+L +++DG
Sbjct: 4147 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADG 4205
Query: 172 E-VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
V+A+G + G++G G++ + P+++ L + +ACG +A+ G VY +G
Sbjct: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKID-VLCGIGIKKVACGTQFSVALTKDGHVYTFG 4264
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+ L G + N P ++ L G+ ++ VA G HTL L G VYAWG+NS GQLG
Sbjct: 4265 QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 4324
Query: 291 TGNKSNQSYPTPVT-VEKDRIIEIAA--CHSTHTSA 323
G+ ++ PT VT ++ + +I+A CHS +A
Sbjct: 4325 LGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
Score = 133 bits (334), Expect = 5e-31
Identities = 93/272 (34%), Positives = 137/272 (50%), Gaps = 16/272 (5%)
Query: 71 GTNCCGCLGLGDV--QSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAY 128
G G LGLGD QST++ + K S GS H + TTEGEVF+WG Y
Sbjct: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDY 487
Query: 129 SQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGS 188
+LG+G ++ P I L K V+ V+ G HS +T DGE++ WG + G++G G
Sbjct: 488 GKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGD 547
Query: 189 TVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG--NGQLGLGNSGNQP 246
+ ++ IP V V ++CG +A+ G VW + G NG+LG G++
Sbjct: 548 SNSRNIPTLVKDISN---VGEVSCGSSHTIALSKDGRT-VWSFGGGDNGKLGHGDTNRVY 603
Query: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE 306
P + ALQG+ +++V G +L LT GQVYAWG + LG G+ S + P +E
Sbjct: 604 KPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGS-SEATALRPKLIE 660
Query: 307 K---DRIIEIAACHSTHTSAAKTQGGHVYMWG 335
+ RI++++ S A + VY WG
Sbjct: 661 ELAATRIVDVSIGDS--HCLALSHDNEVYAWG 690
Score = 133 bits (334), Expect = 5e-31
Identities = 88/259 (33%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 52 GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDS-LNGKKIACLSYGSGPH 110
GS G+ + +TT E+F G G LG G+ + P+ + L GK + C+S G H
Sbjct: 465 GSDGHTLAFTT-EGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYR-H 522
Query: 111 IVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSD 170
T +GE++TWG + +LG+G +N +P + ++SN V EV+CGS H++ L+ D
Sbjct: 523 SAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVK-DISN--VGEVSCGSSHTIALSKD 579
Query: 171 GE-VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229
G V+++G ++G++G G T N+ +V LQ + + G +A+ TG+VY W
Sbjct: 580 GRTVWSFGGGDNGKLGHGDT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
Query: 230 GYNGNGQLGLGNS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288
G LG G+S P + L R+ V+ G +H L L+ + +VYAWG NS GQ
Sbjct: 639 GCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQ 696
Query: 289 LGTGNKSNQSYPTPVTVEK 307
G GN + P+T K
Sbjct: 697 CGQGNSTG-----PITKPK 710
Score = 129 bits (324), Expect = 7e-30
Identities = 85/273 (31%), Positives = 140/273 (51%), Gaps = 9/273 (3%)
Query: 66 EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
E++V G+N L G + ++P+ S + + + G V++T +G V G
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT--IEAGQYCTFVIST-DGSVRACGK 429
Query: 126 NAYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 183
+Y +LG G +N+ L + S K+V H+L T++GEVF+WG + G+
Sbjct: 430 GSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGK 489
Query: 184 VGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG 243
+G G++ Q P+ + G LQ KVVV ++ G AV + GE+Y WG G+LG G+S
Sbjct: 490 LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
Query: 244 NQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQ-VYAWGANSYGQLGTGNKSNQSYPTP 302
++ P V + V V+CG +HT+ L+ +G+ V+++G G+LG G+ +N+ Y
Sbjct: 550 SRNIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGD-TNRVYKPK 606
Query: 303 VTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
V + C + +S A T G VY WG
Sbjct: 607 VIEALQGMFIRKVCAGSQSSLALTSTGQVYAWG 639
Score = 120 bits (302), Expect = 2e-27
Identities = 75/220 (34%), Positives = 117/220 (53%), Gaps = 8/220 (3%)
Query: 119 EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178
+V+ WG + QL N +VP + +QVI CG + V+ ++G V A G
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNV-MVPAAAPSFSQAQQVI---CGQNCTFVIQANGTVLACGE 4053
Query: 179 NNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTI--ACGQMC-CMAVVDTGEVYVWGYNGNG 235
+ G++G G++ + + V LQ VV + +CG MA+ ++GEV+ WG G
Sbjct: 4054 GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4112
Query: 236 QLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKS 295
+LG GNS Q P ++ ALQG V +++CG+ H+ V+T +G+++ +G YG+LG GN S
Sbjct: 4113 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4172
Query: 296 NQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
N+ P VT + I AC HT A G V+ +G
Sbjct: 4173 NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
Score = 92.0 bits (227), Expect = 1e-18
Identities = 54/174 (31%), Positives = 82/174 (47%), Gaps = 6/174 (3%)
Query: 166 VLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGE 225
+++ EV+ WG N+S Q+ G+ P+ + TI GQ C + G
Sbjct: 367 IVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQ---TIEAGQYCTFVISTDGS 423
Query: 226 VYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYA---HTLVLTDEGQVYAWG 282
V G G+LGLG+S NQ T ++ +++V+ HTL T EG+V++WG
Sbjct: 424 VRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWG 483
Query: 283 ANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
YG+LG GN S Q YP + + + SAA T+ G +Y WG+
Sbjct: 484 DGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
Score = 71.2 bits (173), Expect = 2e-12
Identities = 43/127 (33%), Positives = 71/127 (55%), Gaps = 6/127 (4%)
Query: 76 GCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGT 135
G LG GD +P+ +++L G I + GS + L +T G+V+ WG A LG G+
Sbjct: 592 GKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTST-GQVYAWGCGAC--LGCGS 648
Query: 136 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPI- 194
+ + + L+ ++++V+ G H L L+ D EV+AWG N+ GQ G G++ PI
Sbjct: 649 SEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTG-PIT 707
Query: 195 -PRRVTG 200
P++V+G
Sbjct: 708 KPKKVSG 714
Score = 57.0 bits (136), Expect = 4e-08
Identities = 38/136 (27%), Positives = 68/136 (50%), Gaps = 10/136 (7%)
Query: 45 IRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQST-IEPRRLDSLNGKKIACL 103
IR+ C GS + L +T +++ G C CLG G ++T + P+ ++ L +I +
Sbjct: 616 IRKVCA-GSQSSLALTST--GQVYAWG--CGACLGCGSSEATALRPKLIEELAATRIVDV 670
Query: 104 SYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYH 163
S G H + + + EV+ WG+N+ Q G G + + + L + +++ G+ H
Sbjct: 671 SIGDS-HCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSH 729
Query: 164 SLVLTS---DGEVFAW 176
SL T+ D +V AW
Sbjct: 730 SLAWTALPRDRQVVAW 745
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 151 bits (381), Expect = 2e-36
Identities = 96/276 (34%), Positives = 143/276 (51%), Gaps = 5/276 (1%)
Query: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
S G TV+ ++F G G LG + +PR +++L K+I ++ GS H
Sbjct: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS-HSA 3112
Query: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSY--HSLVLTSD 170
T+ GE++TWG Y +LG+G L P + L ++ VI+VACGS +L LT +
Sbjct: 3113 ALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHR-VIQVACGSRDAQTLALTDE 3171
Query: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
G VF+WG + G++G G + IP+ + L + V I CG +A+ +G V+ WG
Sbjct: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFSLALTKSGVVWTWG 3230
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+LG G+ + P V L+G ++ VA G H L +TD GQVYAWG N +GQ G
Sbjct: 3231 KGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
Query: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
G + PT V + + I AC S+H+ A T
Sbjct: 3291 NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
Score = 146 bits (368), Expect = 5e-35
Identities = 88/263 (33%), Positives = 142/263 (53%), Gaps = 13/263 (4%)
Query: 86 TIEPRRLDSLNGKKIACLS-YGSGPHIVLATTEGEVFTWGHNAYSQLGNGTT---NHGLV 141
T+ P+ + L + I ++ + G H + GEV++WG +LG+G T V
Sbjct: 481 TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV 540
Query: 142 PCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC 201
S + K V+ +ACGS +S +T++GE++ WG N G++G GS+ ++ IP V G
Sbjct: 541 ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG- 599
Query: 202 LQNKVVVTIACGQ--MCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRV 259
L+ V+ +ACG +AV + G+V+ WG G+LG G S TP + LQ + V
Sbjct: 600 LKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDV 659
Query: 260 QRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT-VEKDRIIEIAACHS 318
+V CG ++ LT +GQVY+WG +LG G + + YP + ++ ++I++AA S
Sbjct: 660 VKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAA-GS 718
Query: 319 THTSAAKTQGGHVYMWG---QCR 338
TH A T+ V+ WG QC+
Sbjct: 719 TH-CLALTEDSEVHSWGSNDQCQ 740
Score = 146 bits (368), Expect = 5e-35
Identities = 88/276 (31%), Positives = 137/276 (49%), Gaps = 5/276 (1%)
Query: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
S G L + E++ G G LG G+ PR ++SL G ++ ++ G G H
Sbjct: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG-GAHSA 4104
Query: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGS--YHSLVLTSD 170
T G+++TWG Y +LG+ + L P + L +V+++ACGS +L LT D
Sbjct: 4105 CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-LQGHRVVDIACGSGDAQTLCLTDD 4163
Query: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
V++WG + G++G G + +P ++ L VV + CG +A+ +G VY WG
Sbjct: 4164 DTVWSWGDGDYGKLGRGGSDGCKVPMKIDS-LTGLGVVKVECGSQFSVALTKSGAVYTWG 4222
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+LG G+ + P +V LQG +V +A G H + T++G+VY WG N GQLG
Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
Query: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
G + P V + + + AC S HT A T
Sbjct: 4283 DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWST 4318
Score = 144 bits (362), Expect = 3e-34
Identities = 98/307 (31%), Positives = 151/307 (49%), Gaps = 23/307 (7%)
Query: 40 EELQLIRQACVFGSAGNEVLYT-TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNG- 97
E L +R + G G + L+ T + +++ G G LG+G +S P L+S+
Sbjct: 3980 EALATLRPVQLIG--GEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHV 4037
Query: 98 --KKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPC---HISTNLSNK 152
KK+A S G H + ++EGEV++WG +LG+G + PC + +L
Sbjct: 4038 FIKKVAVNS--GGKHCLALSSEGEVYSWGEAEDGKLGHGNRS----PCDRPRVIESLRGI 4091
Query: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212
+V++VA G HS +T+ G+++ WG G++G + +Q P+ V LQ VV IAC
Sbjct: 4092 EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-LQGHRVVDIAC 4150
Query: 213 G----QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAH 268
G Q C+ DT V+ WG G+LG G S P ++ +L G+ V +V CG
Sbjct: 4151 GSGDAQTLCLTDDDT--VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQF 4208
Query: 269 TLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQG 328
++ LT G VY WG Y +LG G+ + P V + + + A S H T+
Sbjct: 4209 SVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCC-TED 4267
Query: 329 GHVYMWG 335
G VY WG
Sbjct: 4268 GEVYTWG 4274
Score = 141 bits (355), Expect = 2e-33
Identities = 95/290 (32%), Positives = 144/290 (49%), Gaps = 12/290 (4%)
Query: 53 SAGNEVLYT-TVNDEIFVLGTNCCGCLGLGDVQSTIE-PRRLDSLNG---KKIACLSYGS 107
+ G++ L+ TV +++ G G LGLG T+ PR++ +L+ KK+A +
Sbjct: 2998 AGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAV--HSG 3055
Query: 108 GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVL 167
G H T +G+VF+WG +LG+ + + P I L K++ ++ACGS HS L
Sbjct: 3056 GRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA-LKTKRIRDIACGSSHSAAL 3114
Query: 168 TSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCC--MAVVDTGE 225
TS GE++ WG G++G G Q P+ V L ++V+ +ACG +A+ D G
Sbjct: 3115 TSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVI-QVACGSRDAQTLALTDEGL 3173
Query: 226 VYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANS 285
V+ WG G+LG G S P + L G V ++ CG +L LT G V+ WG
Sbjct: 3174 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGD 3233
Query: 286 YGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Y +LG G+ + P V + + I A + H A T G VY WG
Sbjct: 3234 YFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAV-TDSGQVYAWG 3282
Score = 132 bits (331), Expect = 1e-30
Identities = 80/245 (32%), Positives = 127/245 (51%), Gaps = 15/245 (6%)
Query: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKK-------IACLSY 105
S G+ L E++ G G LG GD EP+ + + +GK+ IAC
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIAC--- 558
Query: 106 GSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGS--YH 163
+ T EGE++TWG Y +LG+G++ +P ++ L +VI+VACGS
Sbjct: 559 -GSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVA-GLKGLKVIDVACGSGDAQ 616
Query: 164 SLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDT 223
+L +T +G+V++WG + G++G G + P+ + LQ+ VV + CG +A+
Sbjct: 617 TLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEK-LQDLDVVKVRCGSQFSIALTKD 675
Query: 224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA 283
G+VY WG N +LG G + P + LQG +V VA G H L LT++ +V++WG+
Sbjct: 676 GQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGS 735
Query: 284 NSYGQ 288
N Q
Sbjct: 736 NDQCQ 740
Score = 120 bits (300), Expect = 4e-27
Identities = 80/226 (35%), Positives = 119/226 (52%), Gaps = 6/226 (2%)
Query: 114 ATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEV 173
AT +VF WG N QLG + VP S LS V++VA GS +T +G+V
Sbjct: 2955 ATIRTKVFVWGLNDKDQLGGLKGSKIKVPS-FSETLSALNVVQVAGGSKSLFAVTVEGKV 3013
Query: 174 FAWGYNNSGQVGSG-STVNQPIPRRVTGCLQNKVV--VTIACGQMCCMAVVDTGEVYVWG 230
+A G +G++G G S+ PIPR++T L + VV V + G A+ G+V+ WG
Sbjct: 3014 YACGEATNGRLGLGISSGTVPIPRQITA-LSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+G+LG + N P + AL+ R++ +ACG +H+ LT G++Y WG YG+LG
Sbjct: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
Query: 291 TGNKSNQSYPTPVTV-EKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
G+ + Q P V V R+I++A + A T G V+ WG
Sbjct: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3178
Score = 115 bits (287), Expect = 1e-25
Identities = 85/280 (30%), Positives = 124/280 (44%), Gaps = 60/280 (21%)
Query: 119 EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACG------------------ 160
EV WG + N G + C L+N V ++AC
Sbjct: 424 EVIGWGLIGWKYYANVI---GPIQCE---GLANLGVTQIACAEKRFLILSRNGRVYTQAY 477
Query: 161 --------------------------SYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPI 194
+H L L + GEV++WG + G++G G TV
Sbjct: 478 NSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEE 537
Query: 195 PRRV---TGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
P+ + +G K VV IACG A+ GE+Y WG G+LG G+S ++ P V
Sbjct: 538 PKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLV 597
Query: 252 AALQGIRVQRVACGY--AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDR 309
A L+G++V VACG A TL +T+ GQV++WG YG+LG G + TP +EK +
Sbjct: 598 AGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRG--GSDGCKTPKLIEKLQ 655
Query: 310 IIEIAACH-STHTSAAKTQGGHVYMWGQCRGQSVILPHLT 348
+++ + S A T+ G VY WG +G + L H T
Sbjct: 656 DLDVVKVRCGSQFSIALTKDGQVYSWG--KGDNQRLGHGT 693
Score = 110 bits (276), Expect = 3e-24
Identities = 71/223 (31%), Positives = 107/223 (47%), Gaps = 9/223 (4%)
Query: 118 GEVFTWGHNAYSQLGN--GTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFA 175
G ++ WGHN QLG G PC L Q+I G +T+DG+++A
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIG---GEQTLFAVTADGKLYA 4008
Query: 176 WGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV--VTIACGQMCCMAVVDTGEVYVWGYNG 233
GY G++G G T + P + +Q+ + V + G C+A+ GEVY WG
Sbjct: 4009 TGYGAGGRLGIGGTESVSTPTLLES-IQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
Query: 234 NGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN 293
+G+LG GN P + +L+GI V VA G AH+ +T G +Y WG YG+LG +
Sbjct: 4068 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127
Query: 294 KSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
+Q P V ++ R+++IA + T V+ WG
Sbjct: 4128 SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWG 4170
Score = 89.7 bits (221), Expect = 6e-18
Identities = 61/172 (35%), Positives = 86/172 (50%), Gaps = 5/172 (2%)
Query: 42 LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIA 101
L++I AC GS + L T N +++ G G LG G P+ ++ L +
Sbjct: 603 LKVIDVAC--GSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV 660
Query: 102 CLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGS 161
+ GS I L T +G+V++WG +LG+GT H P + L K+VI+VA GS
Sbjct: 661 KVRCGSQFSIAL-TKDGQVYSWGKGDNQRLGHGTEEHVRYP-KLLEGLQGKKVIDVAAGS 718
Query: 162 YHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACG 213
H L LT D EV +WG N+ Q V +P P + G L K +V IACG
Sbjct: 719 THCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPG-LDTKHIVGIACG 769
Score = 58.2 bits (139), Expect = 2e-08
Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 5/117 (4%)
Query: 223 TGEVYVWGYNGNGQLG--LGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+G +Y WG+N GQLG G PTPC AL +R ++ G +T +G++YA
Sbjct: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCE--ALATLRPVQLIGGEQTLFAVTADGKLYA 4008
Query: 281 WGANSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
G + G+LG G + S PT + +++ I ++A A + G VY WG+
Sbjct: 4009 TGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
Score = 31.2 bits (69), Expect = 2.6
Identities = 17/56 (30%), Positives = 30/56 (53%)
Query: 62 TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTE 117
T + E++ G N G LG G + PR + +L GKK+ ++ GS + +T++
Sbjct: 4265 TEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK 4320
Score = 30.0 bits (66), Expect = 5.7
Identities = 14/34 (41%), Positives = 16/34 (47%)
Query: 269 TLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTP 302
TL G +Y WG N GQLG + PTP
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTP 3978
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 150 bits (378), Expect = 4e-36
Identities = 91/288 (31%), Positives = 149/288 (51%), Gaps = 6/288 (2%)
Query: 55 GNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLA 114
GN ++ + E++ G N G LG + +P ++ +L + I ++ G H +
Sbjct: 43 GNHSVFLLEDGEVYTCGLNTKG--QLGHEREGNKPEQIGALADQHIIHVACGES-HSLAL 99
Query: 115 TTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVF 174
+ G++F+WG + QLG TT + + L+ + +++V+CG++H L L +DG+ F
Sbjct: 100 SDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFF 159
Query: 175 AWGYNNSGQVGSGSTV-NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG 233
WG N+ GQ+G G +Q P+RV L+ + +A G A+ +G V+ WG N
Sbjct: 160 TWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 218
Query: 234 NGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN 293
GQLGL + ++ +PC V L+ +V ++CG HT VLT G V+ +GA S GQLG +
Sbjct: 219 AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDS 278
Query: 294 KSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG-QCRGQ 340
+++ P V + AC HT A G +Y +G RGQ
Sbjct: 279 MNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQ 326
Score = 135 bits (340), Expect = 1e-31
Identities = 82/240 (34%), Positives = 122/240 (50%), Gaps = 4/240 (1%)
Query: 66 EIFVLGTNCCGCLGLGDVQSTIE-PRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWG 124
++F G G LGL + ++ PR + LN + I +S G+ H + +G+ FTWG
Sbjct: 104 QLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNW-HCLALAADGQFFTWG 162
Query: 125 HNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQV 184
N++ QLG G +L + +VA G HS L+ G VF WG NN+GQ+
Sbjct: 163 KNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQL 222
Query: 185 GSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGN 244
G ++ P V L+ + VV I+CG+ + +G V+ +G GQLG + +
Sbjct: 223 GLSDEKDRESPCHVK-LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMND 281
Query: 245 QPTPCRVAALQGIRVQRVACGYAHTLVLT-DEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
+ P RV L G V ++ACG HTL G +YA+G + GQLGTG+ N P+PV
Sbjct: 282 EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 341
Score = 119 bits (297), Expect = 9e-27
Identities = 77/266 (28%), Positives = 122/266 (45%), Gaps = 55/266 (20%)
Query: 123 WGHNAYSQLGNGTTNHGLVP-CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
WG+ + Q G T G+V + +S++ V EVACG HS+ L DGEV+ G N
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 182 GQVGSGSTVNQP------------------------------------------------ 193
GQ+G N+P
Sbjct: 64 GQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTED 123
Query: 194 ---IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNS-GNQPTPC 249
+PR + L + ++ ++CG C+A+ G+ + WG N +GQLGLG +Q +P
Sbjct: 124 SVAVPRLIQK-LNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQ 182
Query: 250 RVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDR 309
RV +L+GI + +VA G AH+ L+ G V+ WG N+ GQLG ++ ++ P V + + +
Sbjct: 183 RVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ 242
Query: 310 IIEIAACHSTHTSAAKTQGGHVYMWG 335
+ +C HT A T+ G V+ +G
Sbjct: 243 KVVYISCGEEHT-AVLTKSGGVFTFG 267
Score = 107 bits (268), Expect = 2e-23
Identities = 75/212 (35%), Positives = 106/212 (50%), Gaps = 6/212 (2%)
Query: 43 QLIRQACVFGSAGN-EVLYTTVNDEIFVLGTNCCGCLGLG-DVQSTIEPRRLDSLNGKKI 100
+L +Q + S GN L + + F G N G LGLG + S P+R+ SL G +
Sbjct: 133 KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 192
Query: 101 ACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACG 160
A ++ G G H + G VF WG N QLG PCH+ L ++V+ ++CG
Sbjct: 193 AQVAAG-GAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKL-LRTQKVVYISCG 250
Query: 161 SYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAV 220
H+ VLT G VF +G + GQ+G S ++ PRRV L V IACG+ +A
Sbjct: 251 EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLE-LMGSEVTQIACGRQHTLAF 309
Query: 221 V-DTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
V +G +Y +G GQLG G++ N P V
Sbjct: 310 VPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 341
Score = 72.4 bits (176), Expect = 1e-12
Identities = 45/140 (32%), Positives = 70/140 (50%), Gaps = 3/140 (2%)
Query: 62 TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121
+++ +F G N G LGL D + P + L +K+ +S G H + T G VF
Sbjct: 206 SLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGE-EHTAVLTKSGGVF 264
Query: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLT-SDGEVFAWGYNN 180
T+G + QLG+ + N + P + L +V ++ACG H+L S G ++A+G
Sbjct: 265 TFGAGSCGQLGHDSMNDEVNPRRV-LELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGA 323
Query: 181 SGQVGSGSTVNQPIPRRVTG 200
GQ+G+G T N P V G
Sbjct: 324 RGQLGTGHTCNVKCPSPVKG 343
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 149 bits (375), Expect = 8e-36
Identities = 88/265 (33%), Positives = 139/265 (52%), Gaps = 6/265 (2%)
Query: 75 CGCLGLGDV---QSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQL 131
CGC LG + +S +P ++ +L+ + I +S G H + +G+V+ WG ++ QL
Sbjct: 58 CGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEA-HTLALNDKGQVYAWGLDSDGQL 116
Query: 132 GN-GTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTV 190
G G+ VP +I + LS+ Q+++VACG YHSL L+ EVF WG N GQ+G G+
Sbjct: 117 GLVGSEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDC 175
Query: 191 NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCR 250
+ ++ L + +A G + +G ++ WG N GQLGL + ++ P
Sbjct: 176 KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235
Query: 251 VAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRI 310
+ +L+ ++ + CG HT LT EG V+ +GA YGQLG + S++ P V I
Sbjct: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
Query: 311 IEIAACHSTHTSAAKTQGGHVYMWG 335
+ AC HTSA G +Y +G
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFG 320
Score = 141 bits (355), Expect = 2e-33
Identities = 91/269 (33%), Positives = 141/269 (52%), Gaps = 10/269 (3%)
Query: 71 GTNCCGCLGLG--DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAY 128
G G LGLG D + +EPR+ D K++ + G H V +G V+T G N
Sbjct: 5 GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLR-HTVFVLDDGTVYTCGCNDL 63
Query: 129 SQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVG-SG 187
QLG+ + P + L + ++ V+CG H+L L G+V+AWG ++ GQ+G G
Sbjct: 64 GQLGHEKSRK--KPEQV-VALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 188 STVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLG-NSGNQP 246
S +PR + L + +V +ACG +A+ EV+ WG N GQLGLG + Q
Sbjct: 121 SEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
Query: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE 306
+P + +L GI +VA G AH+ VLT G ++ WG N +GQLG +++++ P +
Sbjct: 180 SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Query: 307 KDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
+ + I C HT+A +GG V+ +G
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGG-VFTFG 267
Score = 130 bits (326), Expect = 4e-30
Identities = 89/269 (33%), Positives = 134/269 (49%), Gaps = 7/269 (2%)
Query: 39 EEELQLIRQACVFGSAGNEVLYTTVND--EIFVLGTNCCGCLGLGDVQSTIE-PRRLDSL 95
E+ + L Q V S G E +ND +++ G + G LGL + I PR + SL
Sbjct: 76 EQVVALDAQNIVAVSCG-EAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 96 NGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVI 155
+ +I ++ G H + + EVF WG N Y QLG GT + +L +
Sbjct: 135 SDIQIVQVACGYY-HSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
Query: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215
+VA G HS VLT G +F WG N GQ+G ++ +P + L+++ +V I CG+
Sbjct: 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGED 252
Query: 216 CCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT-D 274
A+ G V+ +G G GQLG ++ ++ P +V L G V +ACG HT
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPS 312
Query: 275 EGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
G++Y++G GQLGTG+ SN+ P V
Sbjct: 313 SGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341
Score = 117 bits (292), Expect = 4e-26
Identities = 74/216 (34%), Positives = 115/216 (53%), Gaps = 9/216 (4%)
Query: 38 SEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLG-DVQSTIEPRRLDSLN 96
S ++Q+++ AC + + L + E+F G N G LGLG D + P+ L SL
Sbjct: 133 SLSDIQIVQVACGYYHS----LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
Query: 97 GKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIE 156
G ++ G G H + T G +F WG N + QLG N VP ++ +L +++++
Sbjct: 189 GIPFMQVAAG-GAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP-NLLKSLRSQKIVY 246
Query: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMC 216
+ CG H+ LT +G VF +G GQ+G ST ++ PR+V L +V IACG+
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE-LMGSIVTEIACGRQH 305
Query: 217 CMAVV-DTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
A V +G +Y +G GNGQLG G++ N+ +P V
Sbjct: 306 TSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341
Score = 116 bits (291), Expect = 5e-26
Identities = 68/216 (31%), Positives = 109/216 (50%), Gaps = 5/216 (2%)
Query: 123 WGHNAYSQLGNGTTNHGLV-PCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
WG+ ++ QLG G + +V S NK+V +V CG H++ + DG V+ G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGL-G 240
GQ+G + +P L + +V ++CG+ +A+ D G+VY WG + +GQLGL G
Sbjct: 64 GQLGHEKSRKKP---EQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 241 NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300
+ P + +L I++ +VACGY H+L L+ +V+ WG N YGQLG G +
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 301 TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
+ I + S T G ++ WG+
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
Score = 86.7 bits (213), Expect = 5e-17
Identities = 54/149 (36%), Positives = 75/149 (50%), Gaps = 3/149 (2%)
Query: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
+ G T++ IF G N G LGL D P L SL +KI + G H
Sbjct: 197 AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGED-HTA 255
Query: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYH-SLVLTSDG 171
T EG VFT+G Y QLG+ +T+H + P + L V E+ACG H S + S G
Sbjct: 256 ALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSG 314
Query: 172 EVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200
++++G +GQ+G+GST N+ P V G
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Score = 37.0 bits (84), Expect = 0.047
Identities = 20/82 (24%), Positives = 35/82 (42%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+F G G LG I PR++ L G + ++ G + G ++++G
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLG 322
Query: 127 AYSQLGNGTTNHGLVPCHISTN 148
QLG G+T++ P + N
Sbjct: 323 GNGQLGTGSTSNRKSPFTVKGN 344
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 149 bits (375), Expect = 8e-36
Identities = 88/265 (33%), Positives = 139/265 (52%), Gaps = 6/265 (2%)
Query: 75 CGCLGLGDV---QSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQL 131
CGC LG + +S +P ++ +L+ + I +S G H + +G+V+ WG ++ QL
Sbjct: 58 CGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEA-HTLALNDKGQVYAWGLDSDGQL 116
Query: 132 GN-GTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTV 190
G G+ VP +I + LS+ Q+++VACG YHSL L+ EVF WG N GQ+G G+
Sbjct: 117 GLVGSEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDC 175
Query: 191 NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCR 250
+ ++ L + +A G + +G ++ WG N GQLGL + ++ P
Sbjct: 176 KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235
Query: 251 VAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRI 310
+ +L+ ++ + CG HT LT EG V+ +GA YGQLG + S++ P V I
Sbjct: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
Query: 311 IEIAACHSTHTSAAKTQGGHVYMWG 335
+ AC HTSA G +Y +G
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFG 320
Score = 141 bits (355), Expect = 2e-33
Identities = 91/269 (33%), Positives = 141/269 (52%), Gaps = 10/269 (3%)
Query: 71 GTNCCGCLGLG--DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAY 128
G G LGLG D + +EPR+ D K++ + G H V +G V+T G N
Sbjct: 5 GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLR-HTVFVLDDGTVYTCGCNDL 63
Query: 129 SQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVG-SG 187
QLG+ + P + L + ++ V+CG H+L L G+V+AWG ++ GQ+G G
Sbjct: 64 GQLGHEKSRK--KPEQV-VALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 188 STVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLG-NSGNQP 246
S +PR + L + +V +ACG +A+ EV+ WG N GQLGLG + Q
Sbjct: 121 SEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
Query: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE 306
+P + +L GI +VA G AH+ VLT G ++ WG N +GQLG +++++ P +
Sbjct: 180 SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Query: 307 KDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
+ + I C HT+A +GG V+ +G
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGG-VFTFG 267
Score = 130 bits (326), Expect = 4e-30
Identities = 89/269 (33%), Positives = 134/269 (49%), Gaps = 7/269 (2%)
Query: 39 EEELQLIRQACVFGSAGNEVLYTTVND--EIFVLGTNCCGCLGLGDVQSTIE-PRRLDSL 95
E+ + L Q V S G E +ND +++ G + G LGL + I PR + SL
Sbjct: 76 EQVVALDAQNIVAVSCG-EAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 96 NGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVI 155
+ +I ++ G H + + EVF WG N Y QLG GT + +L +
Sbjct: 135 SDIQIVQVACGYY-HSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
Query: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215
+VA G HS VLT G +F WG N GQ+G ++ +P + L+++ +V I CG+
Sbjct: 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGED 252
Query: 216 CCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT-D 274
A+ G V+ +G G GQLG ++ ++ P +V L G V +ACG HT
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPS 312
Query: 275 EGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
G++Y++G GQLGTG+ SN+ P V
Sbjct: 313 SGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341
Score = 117 bits (292), Expect = 4e-26
Identities = 74/216 (34%), Positives = 115/216 (53%), Gaps = 9/216 (4%)
Query: 38 SEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLG-DVQSTIEPRRLDSLN 96
S ++Q+++ AC + + L + E+F G N G LGLG D + P+ L SL
Sbjct: 133 SLSDIQIVQVACGYYHS----LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
Query: 97 GKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIE 156
G ++ G G H + T G +F WG N + QLG N VP ++ +L +++++
Sbjct: 189 GIPFMQVAAG-GAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP-NLLKSLRSQKIVY 246
Query: 157 VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMC 216
+ CG H+ LT +G VF +G GQ+G ST ++ PR+V L +V IACG+
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE-LMGSIVTEIACGRQH 305
Query: 217 CMAVV-DTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
A V +G +Y +G GNGQLG G++ N+ +P V
Sbjct: 306 TSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341
Score = 116 bits (291), Expect = 5e-26
Identities = 68/216 (31%), Positives = 109/216 (50%), Gaps = 5/216 (2%)
Query: 123 WGHNAYSQLGNGTTNHGLV-PCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
WG+ ++ QLG G + +V S NK+V +V CG H++ + DG V+ G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGL-G 240
GQ+G + +P L + +V ++CG+ +A+ D G+VY WG + +GQLGL G
Sbjct: 64 GQLGHEKSRKKP---EQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 241 NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300
+ P + +L I++ +VACGY H+L L+ +V+ WG N YGQLG G +
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 301 TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
+ I + S T G ++ WG+
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
Score = 86.7 bits (213), Expect = 5e-17
Identities = 54/149 (36%), Positives = 75/149 (50%), Gaps = 3/149 (2%)
Query: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
+ G T++ IF G N G LGL D P L SL +KI + G H
Sbjct: 197 AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGED-HTA 255
Query: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYH-SLVLTSDG 171
T EG VFT+G Y QLG+ +T+H + P + L V E+ACG H S + S G
Sbjct: 256 ALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSG 314
Query: 172 EVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200
++++G +GQ+G+GST N+ P V G
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Score = 37.0 bits (84), Expect = 0.047
Identities = 20/82 (24%), Positives = 35/82 (42%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+F G G LG I PR++ L G + ++ G + G ++++G
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLG 322
Query: 127 AYSQLGNGTTNHGLVPCHISTN 148
QLG G+T++ P + N
Sbjct: 323 GNGQLGTGSTSNRKSPFTVKGN 344
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 139 bits (349), Expect = 9e-33
Identities = 99/280 (35%), Positives = 145/280 (51%), Gaps = 10/280 (3%)
Query: 62 TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121
T N+++++ G+N G LGLG + +P + +L +K+ + G H +++T G V+
Sbjct: 51 TGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNVY 109
Query: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
G N QLG G T IS S ++ +++ GS S LT DG +F WG N+
Sbjct: 110 ATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSE 169
Query: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN 241
GQ+G + N +P++VT K V I+CG V GE+YV+G NG+LGL N
Sbjct: 170 GQIGLKNVSNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226
Query: 242 S--GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN-KSNQS 298
GN TP V+ + +V +VACG HT+VLT E VY +G +GQLG G S
Sbjct: 227 QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETS 284
Query: 299 YPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCR 338
P + +D+ I +C HT A T G +Y +G R
Sbjct: 285 EPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
Score = 99.8 bits (247), Expect = 6e-21
Identities = 72/236 (30%), Positives = 116/236 (49%), Gaps = 18/236 (7%)
Query: 113 LATTEGEVFTWGHNAYSQLGNGTT-NHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171
L G VFT+G + +++ G VP H+S CG HS V+T +
Sbjct: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLS------------CGDEHSAVVTGNN 54
Query: 172 EVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGY 231
+++ +G NN GQ+G GS P V KV + ACG+ + + G VY G
Sbjct: 55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLA-ACGRNHTLVSTEGGNVYATGG 113
Query: 232 NGNGQLGLGNSGNQPTPCRVAALQG-IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
N GQLGLG++ + T ++ ++++++ G + LT++G+++ WG NS GQ+G
Sbjct: 114 NNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIG 173
Query: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPH 346
N SN P VT+ K + +C H SA T G +Y++G+ + LP+
Sbjct: 174 LKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYVFGEPENGKLGLPN 226
Score = 86.3 bits (212), Expect = 7e-17
Identities = 66/225 (29%), Positives = 115/225 (51%), Gaps = 13/225 (5%)
Query: 53 SAGNEVLYTTVND-EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHI 111
SAG+ D +F+ G N G +GL +V + P+++ GK ++ +S G H
Sbjct: 146 SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY-HS 202
Query: 112 VLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNK---QVIEVACGSYHSLVLT 168
TT+GE++ +G +LG + L+ H + L ++ +VI+VACG H++VLT
Sbjct: 203 AFVTTDGELYVFGEPENGKLG---LPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT 259
Query: 169 SDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
+ V+ +G GQ+G G+ + + +V ++++ + I+CG+ + D G +Y
Sbjct: 260 ENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYT 318
Query: 229 WGYNGNGQLGLG--NSGNQPTPCRVAALQGIRVQRVACGYAHTLV 271
+G +G+LGLG N N P + V+ VACG H +V
Sbjct: 319 FGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 139 bits (349), Expect = 9e-33
Identities = 99/280 (35%), Positives = 145/280 (51%), Gaps = 10/280 (3%)
Query: 62 TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121
T N+++++ G+N G LGLG + +P + +L +K+ + G H +++T G V+
Sbjct: 51 TGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNVY 109
Query: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
G N QLG G T IS S ++ +++ GS S LT DG +F WG N+
Sbjct: 110 ATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSE 169
Query: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN 241
GQ+G + N +P++VT K V I+CG V GE+YV+G NG+LGL N
Sbjct: 170 GQIGLKNVSNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226
Query: 242 S--GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN-KSNQS 298
GN TP V+ + +V +VACG HT+VLT E VY +G +GQLG G S
Sbjct: 227 QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETS 284
Query: 299 YPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCR 338
P + +D+ I +C HT A T G +Y +G R
Sbjct: 285 EPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
Score = 99.8 bits (247), Expect = 6e-21
Identities = 72/236 (30%), Positives = 116/236 (49%), Gaps = 18/236 (7%)
Query: 113 LATTEGEVFTWGHNAYSQLGNGTT-NHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171
L G VFT+G + +++ G VP H+S CG HS V+T +
Sbjct: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLS------------CGDEHSAVVTGNN 54
Query: 172 EVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGY 231
+++ +G NN GQ+G GS P V KV + ACG+ + + G VY G
Sbjct: 55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLA-ACGRNHTLVSTEGGNVYATGG 113
Query: 232 NGNGQLGLGNSGNQPTPCRVAALQG-IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
N GQLGLG++ + T ++ ++++++ G + LT++G+++ WG NS GQ+G
Sbjct: 114 NNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIG 173
Query: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPH 346
N SN P VT+ K + +C H SA T G +Y++G+ + LP+
Sbjct: 174 LKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYVFGEPENGKLGLPN 226
Score = 86.3 bits (212), Expect = 7e-17
Identities = 66/225 (29%), Positives = 115/225 (51%), Gaps = 13/225 (5%)
Query: 53 SAGNEVLYTTVND-EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHI 111
SAG+ D +F+ G N G +GL +V + P+++ GK ++ +S G H
Sbjct: 146 SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY-HS 202
Query: 112 VLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNK---QVIEVACGSYHSLVLT 168
TT+GE++ +G +LG + L+ H + L ++ +VI+VACG H++VLT
Sbjct: 203 AFVTTDGELYVFGEPENGKLG---LPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT 259
Query: 169 SDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
+ V+ +G GQ+G G+ + + +V ++++ + I+CG+ + D G +Y
Sbjct: 260 ENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYT 318
Query: 229 WGYNGNGQLGLG--NSGNQPTPCRVAALQGIRVQRVACGYAHTLV 271
+G +G+LGLG N N P + V+ VACG H +V
Sbjct: 319 FGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 134 bits (338), Expect = 2e-31
Identities = 78/243 (32%), Positives = 128/243 (52%), Gaps = 6/243 (2%)
Query: 95 LNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQV 154
L KKI ++ G H + + GE+F WG N + QLG G I +L+ +
Sbjct: 135 LQEKKIIQITCGDY-HSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPL 193
Query: 155 IEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQ 214
+++ G HS+ L+ G +++WG N GQ+G G T ++ P + G L N+ V +ACG
Sbjct: 194 AQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVACGG 252
Query: 215 MCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLV-LT 273
+ G ++ +G +GQLG ++ N+ PC VA L G RV ++ACG HTL ++
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
Query: 274 DEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGH--V 331
D G+V+++G+ GQLG G +Q P PV V +++ + H++ GG+ +
Sbjct: 313 DLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLES-HTSEKELIMIAGGNQSI 371
Query: 332 YMW 334
+W
Sbjct: 372 LLW 374
Score = 127 bits (320), Expect = 2e-29
Identities = 73/240 (30%), Positives = 121/240 (50%), Gaps = 13/240 (5%)
Query: 97 GKKIACLSYGSGP-HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVI 155
GK + S G H+++ +++G+ F + N+ + + L K++I
Sbjct: 94 GKNMKIHSVDQGAEHMLILSSDGKPFEYD------------NYSMKHLRFESILQEKKII 141
Query: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215
++ CG YHSL L+ GE+FAWG N GQ+G G ++ L + I+ G+
Sbjct: 142 QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEA 201
Query: 216 CCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDE 275
MA+ +G +Y WG N GQLGLG++ ++ P + L +V+ VACG +H+ +LT +
Sbjct: 202 HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQD 261
Query: 276 GQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
G ++ +GA +GQLG + N+ P V + AC HT A + G V+ +G
Sbjct: 262 GLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFG 321
Score = 93.6 bits (231), Expect = 4e-19
Identities = 52/148 (35%), Positives = 90/148 (60%), Gaps = 5/148 (3%)
Query: 62 TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121
+++ I+ G N CG LGLG +S +P ++ L+ +K+ ++ G G H L T +G +F
Sbjct: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACG-GSHSALLTQDGLLF 265
Query: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSD-GEVFAWGYNN 180
T+G + QLG+ +T + L PC ++ L +V ++ACG +H+L SD G+VF++G
Sbjct: 266 TFGAGKHGQLGHNSTQNELRPCLVA-ELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGK 324
Query: 181 SGQVGSGSTVNQ--PIPRRVTGCLQNKV 206
GQ+G+G T +Q P+P +V+ + K+
Sbjct: 325 DGQLGNGGTRDQLMPLPVKVSSSEELKL 352
Score = 42.7 bits (99), Expect = 9e-04
Identities = 26/102 (25%), Positives = 46/102 (45%)
Query: 55 GNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLA 114
G+ T + +F G G LG Q+ + P + L G ++ ++ G +
Sbjct: 252 GSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYV 311
Query: 115 TTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIE 156
+ G+VF++G QLGNG T L+P + + S + +E
Sbjct: 312 SDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLE 353
Score = 37.4 bits (85), Expect = 0.036
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 21/127 (16%)
Query: 214 QMCC----MAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269
Q+CC +AV++ G V + QL L SG TP + + +++ V G H
Sbjct: 55 QLCCSPGRLAVLERGGAGVQVH----QL-LAGSGGARTPKCIKLGKNMKIHSVDQGAEHM 109
Query: 270 LVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGG 329
L+L+ +G+ + + N S + +++ +II+I C H S A ++GG
Sbjct: 110 LILSSDGKPFEYD----------NYSMKHLRFESILQEKKIIQIT-CGDYH-SLALSKGG 157
Query: 330 HVYMWGQ 336
++ WGQ
Sbjct: 158 ELFAWGQ 164
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 129 bits (324), Expect = 7e-30
Identities = 104/311 (33%), Positives = 144/311 (46%), Gaps = 24/311 (7%)
Query: 41 ELQLIRQACVFGSAGNEVLYTT----------VNDEIFVLGTNCCGCLGLGDVQSTIEPR 90
ELQ R A GS G E+L N + G N G LG Q P
Sbjct: 11 ELQRRRTA---GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPE 67
Query: 91 RLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNH-GLVPCHISTNL 149
+ +L + +S G H + +G VF WG + QLG G P I T L
Sbjct: 68 PIQALETLIVDLVSCGK-EHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMT-L 125
Query: 150 SNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTV-NQPIPRRVTGCLQNKVVV 208
++ ++I+V+CG YHSL L+ D +VF+WG N+ GQ+G G +Q P+RV L+ +
Sbjct: 126 NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLA 184
Query: 209 TIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT----PCRVAALQGIRVQRVAC 264
+A G A+ G + WG N GQL L + N P P V AL+ + V ++C
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLAL-SGRNVPVQSNKPLSVGALKNLGVVYISC 243
Query: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAA 324
G AHT VLT +G+V+ +G N GQLG + P V D ++ C S HT A
Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVE-RIDGLVSQIDCGSYHTLAY 302
Query: 325 KTQGGHVYMWG 335
G V +G
Sbjct: 303 VHTTGQVVSFG 313
Score = 69.3 bits (168), Expect = 9e-12
Identities = 45/149 (30%), Positives = 76/149 (51%), Gaps = 6/149 (4%)
Query: 191 NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCR 250
++ + RR T ++ A G+ + ++ V G N GQLG + P
Sbjct: 9 SRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEP 68
Query: 251 VAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTP---VTVEK 307
+ AL+ + V V+CG H+L + +G+V+AWGA S GQLG G S+ TP +T+
Sbjct: 69 IQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISF-TPKKIMTLND 127
Query: 308 DRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
+II+++ H + S A ++ V+ WG+
Sbjct: 128 IKIIQVSCGH--YHSLALSKDSQVFSWGK 154
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 120 bits (302), Expect = 2e-27
Identities = 76/276 (27%), Positives = 133/276 (48%), Gaps = 19/276 (6%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
I G+ GCLG G + +P +++L G ++ ++ G+ H++ +TE E+F WG
Sbjct: 412 IMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGAS-HVLALSTERELFAWGRG 470
Query: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186
+LG GT P + ++ V CG S++LT G+ A G N ++G
Sbjct: 471 DSGRLGLGTRESHSCPQQVPMP-PGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGL 529
Query: 187 G--STVNQPIPRRV-----------TGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG 233
S +P+P + + L + +++I G AV +G+ Y +G N
Sbjct: 530 DHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQ 589
Query: 234 NGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN 293
+GQLG PC+V L+GI++ VACG A T+ + E +VY+WG + G+LG +
Sbjct: 590 HGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRD 649
Query: 294 KSNQSYPTPVTVEKDR---IIEIAACHSTHTSAAKT 326
+ + P PV +++ + ++ CH A ++
Sbjct: 650 E-DAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRS 684
Score = 90.5 bits (223), Expect = 4e-18
Identities = 63/205 (30%), Positives = 94/205 (45%), Gaps = 9/205 (4%)
Query: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGS----TVNQPIPRRVTGCLQNKV 206
N +V++VA G +T G + W G G GS V QP P+ ++ L+ +
Sbjct: 331 NTEVVQVAAGRTQKAGVTRSGRLILWEAPPLG-AGGGSLLPGAVEQPQPQFISRFLEGQS 389
Query: 207 VVTI---ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVA 263
VTI ACG + D G + +G NG LG G+ + P V AL G + +VA
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVA 449
Query: 264 CGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
CG +H L L+ E +++AWG G+LG G + + S P V + + + C +S
Sbjct: 450 CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVC-GIDSSM 508
Query: 324 AKTQGGHVYMWGQCRGQSVILPHLT 348
T G G R + L HL+
Sbjct: 509 ILTVPGQALACGSNRFNKLGLDHLS 533
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/201 (28%), Positives = 92/201 (45%), Gaps = 18/201 (8%)
Query: 150 SNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVT 209
S + VACG + + LT G + +G ++G +G GS + P V L + +V
Sbjct: 389 SGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYE-MVQ 447
Query: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269
+ACG +A+ E++ WG +G+LGLG + P +V G QRV CG +
Sbjct: 448 VACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSS 507
Query: 270 LVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTP---------------VTVEKDRIIEIA 314
++LT GQ A G+N + +LG + S P P ++++ ++ I
Sbjct: 508 MILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSID 567
Query: 315 ACHSTHTSAAKTQGGHVYMWG 335
T SAA T G Y +G
Sbjct: 568 L--GTAHSAAVTASGDCYTFG 586
Score = 79.3 bits (194), Expect = 8e-15
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 24/251 (9%)
Query: 43 QLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIAC 102
++++ AC + VL + E+F G G LGLG +S P+++ G++
Sbjct: 444 EMVQVAC----GASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQR 499
Query: 103 LSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHI-------------STNL 149
+ G ++L T G+ G N +++LG + G P S L
Sbjct: 500 VVCGIDSSMIL-TVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558
Query: 150 SNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVT 209
+ ++ + G+ HS +T+ G+ + +G N GQ+G+ + P +V G L+ +
Sbjct: 559 DQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG-LEGIKMAM 617
Query: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLG-LGNSGNQPTPCRVAALQGIRVQRVACGYAH 268
+ACG +A+ EVY WG G+LG P P ++ V V+C + +
Sbjct: 618 VACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGN 677
Query: 269 TLV----LTDE 275
TL+ +TDE
Sbjct: 678 TLLAVRSVTDE 688
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 118 bits (296), Expect = 1e-26
Identities = 82/273 (30%), Positives = 130/273 (47%), Gaps = 28/273 (10%)
Query: 89 PRRLDSLNGKKIACLSYGS-GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
P R L G ++ + GS H +L TTEG++++WG N QLG+G T P +
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
Query: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207
LS++ ++ ACG H+L LT G VFA+G N GQ+G G+ + +P + +
Sbjct: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPI 256
Query: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGN------------QPTPCRVAA-- 253
+ACG M + G +Y +G GQLG + G + P RVA
Sbjct: 257 TKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFI 316
Query: 254 ----------LQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
+ + V+ VACG HTLVL + +V++WG YG+LG + ++ P V
Sbjct: 317 EKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376
Query: 304 TVEKDRIIEIAACHSTHT-SAAKTQGGHVYMWG 335
+ + ++ +T S A ++ G ++ WG
Sbjct: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
Score = 106 bits (265), Expect = 5e-23
Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 41/239 (17%)
Query: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186
AY LG C + + V+ +C + HSL++T++G++++WG N GQ+G
Sbjct: 128 AYRNLGQNLWGPHRYGCLAGVRV--RTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGH 184
Query: 187 GSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ- 245
G T PR + G L ++V+V+ ACG+ +A+ +TG V+ +G N GQLGLGN +
Sbjct: 185 GDTKRVEAPRLIEG-LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAV 243
Query: 246 PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN------------ 293
P+P ++ G + ++ACG ++++ +G +Y++G YGQLG +
Sbjct: 244 PSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIE 302
Query: 294 -----------------KSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
K Q P P V +D AC + HT +Q V+ WG
Sbjct: 303 YDCELVPRRVAIFIEKTKDGQILPVPNVVVRD-----VACGANHTLVLDSQ-KRVFSWG 355
Score = 91.7 bits (226), Expect = 2e-18
Identities = 72/270 (26%), Positives = 121/270 (44%), Gaps = 37/270 (13%)
Query: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLAT 115
N L T +F G N G LGLG+ + NG+ I ++ G+ +++
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM-D 270
Query: 116 TEGEVFTWGHNAYSQLGNGTTNH------------GLVPCHISTNLS-----------NK 152
+G ++++G Y QLG+ + LVP ++ + N
Sbjct: 271 CKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNV 330
Query: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRV-TGCLQNKVVVTIA 211
V +VACG+ H+LVL S VF+WG+ G++G ++ +PR V + I
Sbjct: 331 VVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY 390
Query: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT--PCRVAALQGIRVQRVACGYAHT 269
G C AV + G ++ WG N+ + T P V L G R++ +ACG +
Sbjct: 391 AGYTCSFAVSEVGGLFFWGAT--------NTSRESTMYPKAVQDLCGWRIRSLACGKSSI 442
Query: 270 LVLTDEGQVYAWGAN-SYGQLGTGNKSNQS 298
+V DE + +WG + ++G+LG G+ +S
Sbjct: 443 IVAADESTI-SWGPSPTFGELGYGDHKPKS 471
Score = 90.1 bits (222), Expect = 5e-18
Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 27/267 (10%)
Query: 50 VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109
V GS L T +++ G N G LG GD + PR ++ L+ + I + G
Sbjct: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRN- 212
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
H + T G VF +G N QLG G VP + + + ++ACG+ S+++
Sbjct: 213 HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDC 271
Query: 170 DGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTGCLQ-----------NKV 206
G ++++G GQ+G S + +PRRV ++ N V
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
Query: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTP--CRVAALQGIRVQRVAC 264
V +ACG + + V+ WG+ G G+LG ++ P ++ G ++
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA 391
Query: 265 GYAHTLVLTDEGQVYAWGANSYGQLGT 291
GY + +++ G ++ WGA + + T
Sbjct: 392 GYTCSFAVSEVGGLFFWGATNTSREST 418
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 118 bits (296), Expect = 1e-26
Identities = 82/273 (30%), Positives = 130/273 (47%), Gaps = 28/273 (10%)
Query: 89 PRRLDSLNGKKIACLSYGS-GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
P R L G ++ + GS H +L TTEG++++WG N QLG+G T P +
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
Query: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207
LS++ ++ ACG H+L LT G VFA+G N GQ+G G+ + +P + +
Sbjct: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPI 256
Query: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGN------------QPTPCRVAA-- 253
+ACG M + G +Y +G GQLG + G + P RVA
Sbjct: 257 TKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFI 316
Query: 254 ----------LQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
+ + V+ VACG HTLVL + +V++WG YG+LG + ++ P V
Sbjct: 317 EKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376
Query: 304 TVEKDRIIEIAACHSTHT-SAAKTQGGHVYMWG 335
+ + ++ +T S A ++ G ++ WG
Sbjct: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
Score = 106 bits (265), Expect = 5e-23
Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 41/239 (17%)
Query: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186
AY LG C + + V+ +C + HSL++T++G++++WG N GQ+G
Sbjct: 128 AYRNLGQNLWGPHRYGCLAGVRV--RTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGH 184
Query: 187 GSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ- 245
G T PR + G L ++V+V+ ACG+ +A+ +TG V+ +G N GQLGLGN +
Sbjct: 185 GDTKRVEAPRLIEG-LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAV 243
Query: 246 PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN------------ 293
P+P ++ G + ++ACG ++++ +G +Y++G YGQLG +
Sbjct: 244 PSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIE 302
Query: 294 -----------------KSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
K Q P P V +D AC + HT +Q V+ WG
Sbjct: 303 YDCELVPRRVAIFIEKTKDGQILPVPNVVVRD-----VACGANHTLVLDSQ-KRVFSWG 355
Score = 91.7 bits (226), Expect = 2e-18
Identities = 72/270 (26%), Positives = 121/270 (44%), Gaps = 37/270 (13%)
Query: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLAT 115
N L T +F G N G LGLG+ + NG+ I ++ G+ +++
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM-D 270
Query: 116 TEGEVFTWGHNAYSQLGNGTTNH------------GLVPCHISTNLS-----------NK 152
+G ++++G Y QLG+ + LVP ++ + N
Sbjct: 271 CKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNV 330
Query: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRV-TGCLQNKVVVTIA 211
V +VACG+ H+LVL S VF+WG+ G++G ++ +PR V + I
Sbjct: 331 VVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY 390
Query: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT--PCRVAALQGIRVQRVACGYAHT 269
G C AV + G ++ WG N+ + T P V L G R++ +ACG +
Sbjct: 391 AGYTCSFAVSEVGGLFFWGAT--------NTSRESTMYPKAVQDLCGWRIRSLACGKSSI 442
Query: 270 LVLTDEGQVYAWGAN-SYGQLGTGNKSNQS 298
+V DE + +WG + ++G+LG G+ +S
Sbjct: 443 IVAADESTI-SWGPSPTFGELGYGDHKPKS 471
Score = 90.1 bits (222), Expect = 5e-18
Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 27/267 (10%)
Query: 50 VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109
V GS L T +++ G N G LG GD + PR ++ L+ + I + G
Sbjct: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRN- 212
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
H + T G VF +G N QLG G VP + + + ++ACG+ S+++
Sbjct: 213 HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDC 271
Query: 170 DGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTGCLQ-----------NKV 206
G ++++G GQ+G S + +PRRV ++ N V
Sbjct: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
Query: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTP--CRVAALQGIRVQRVAC 264
V +ACG + + V+ WG+ G G+LG ++ P ++ G ++
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA 391
Query: 265 GYAHTLVLTDEGQVYAWGANSYGQLGT 291
GY + +++ G ++ WGA + + T
Sbjct: 392 GYTCSFAVSEVGGLFFWGATNTSREST 418
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 104 bits (259), Expect = 2e-22
Identities = 80/252 (31%), Positives = 122/252 (48%), Gaps = 18/252 (7%)
Query: 50 VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109
+ G G+ + T D +FV G N G LGLG + SL G I ++ G
Sbjct: 54 ITGGGGHSAVVTDGGD-LFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDF 112
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHI--STNLSNKQVIEVACGSYHSLVL 167
I+L T G+V + G N++ QLG HG C + + L ++V+ +A G H++
Sbjct: 113 TIML-TENGQVLSCGSNSFGQLG---VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAA 168
Query: 168 TSDGEVFAWGYNNSG---QVGSGSTV----NQPIPRRVTGCLQNKVVVTIACGQMCCMAV 220
T+ G VF WG + ++ G T+ P RVTG L+N + + G ++
Sbjct: 169 TASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTG-LENSKAMCVLAGSDHSASL 227
Query: 221 VDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAA--LQGIRVQRVACGYAHTLVLTDEGQV 278
D GEVYVWG N +GQL + P P ++ A Q +V + G+ H + T+ G++
Sbjct: 228 TDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKM 286
Query: 279 YAWGANSYGQLG 290
+ WG YGQLG
Sbjct: 287 FTWGRADYGQLG 298
Score = 103 bits (258), Expect = 3e-22
Identities = 84/289 (29%), Positives = 130/289 (44%), Gaps = 33/289 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+F G N G LGLG + + P++L+ + G G H + T G++F G N
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 127 AYSQLGNGTTNH--GLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQV 184
QLG G T PC +L + +VACG +++LT +G+V + G N+ GQ+
Sbjct: 77 KDGQLGLGHTEDIPYFTPC---KSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQL 133
Query: 185 GSGSTVNQ-PIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG 243
G + +P+ + L + VV IA G +A +G V+ WG GL + G
Sbjct: 134 GVPHGPRRCVVPQAIE--LHKEKVVCIAAGLRHAVAATASGIVFQWG------TGLASCG 185
Query: 244 NQ-------------PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+ P RV L+ + V G H+ LTD G+VY WG+N +GQL
Sbjct: 186 RRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA 245
Query: 291 TGNKSNQSYPTPVTVEKD--RIIEIAACHSTHTS-AAKTQGGHVYMWGQ 336
P P +E + ++ A S T A+T+ G ++ WG+
Sbjct: 246 ---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGR 291
Score = 101 bits (251), Expect = 2e-21
Identities = 82/293 (27%), Positives = 125/293 (42%), Gaps = 42/293 (14%)
Query: 62 TVNDEIFVLGTNCCGCLGLGD-VQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEV 120
T N ++ G+N G LG+ + + P+ ++ L+ +K+ C++ G H V AT G V
Sbjct: 117 TENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLR-HAVAATASGIV 174
Query: 121 FTWGHNAYSQLGNGTTNHGLVPCHIS-------TNLSNKQVIEVACGSYHSLVLTSDGEV 173
F WG + G +P + T L N + + V GS HS LT GEV
Sbjct: 175 FQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEV 233
Query: 174 FAWGYNNSGQVGSGSTVNQPIPRRVTG-CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232
+ WG N GQ+ + + P+P+++ C QN+ V I G +A +TG+++ WG
Sbjct: 234 YVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRA 292
Query: 233 GNGQLGLG----------------------NSGNQPTPCRVAALQGIRVQRVACGYAHTL 270
GQLG NS C A + V+CG H L
Sbjct: 293 DYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATE------VSCGSEHNL 346
Query: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
+ G Y+WG N +G G G ++N P PV + C + H+ A
Sbjct: 347 AIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
Score = 90.1 bits (222), Expect = 5e-18
Identities = 70/247 (28%), Positives = 106/247 (42%), Gaps = 20/247 (8%)
Query: 114 ATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEV 173
A +F WG N+Y QLG G L+P ++ + V + G HS V+T G++
Sbjct: 11 APAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDL 70
Query: 174 FAWGYNNSGQVGSGSTVNQPI---PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
F G N GQ+G G T + P + + GC + +ACG + + + G+V G
Sbjct: 71 FVCGLNKDGQLGLGHTEDIPYFTPCKSLFGC----PIQQVACGWDFTIMLTENGQVLSCG 126
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
N GQLG+ + + + L +V +A G H + T G V+ WG G
Sbjct: 127 SNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG-TGLASCG 185
Query: 291 TGNKSNQSYPTPVTV-EKDRIIEI----AAC--HSTHTSAAKTQGGHVYMW-----GQCR 338
Q+ P T E R+ + A C + SA+ T G VY+W GQ
Sbjct: 186 RRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA 245
Query: 339 GQSVILP 345
++ LP
Sbjct: 246 NEAAFLP 252
Score = 74.3 bits (181), Expect = 3e-13
Identities = 70/257 (27%), Positives = 103/257 (40%), Gaps = 27/257 (10%)
Query: 40 EELQLIRQACVFGSAG-NEVLYTTVNDEIFVLGTNCCGC---LGLGDVQSTI----EPRR 91
+ ++L ++ V +AG + T + +F GT C L G EP R
Sbjct: 146 QAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSR 205
Query: 92 LDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTN-LS 150
+ L K C+ GS H T GEV+ WG N + QL N VP I +
Sbjct: 206 VTGLENSKAMCVLAGSD-HSASLTDAGEVYVWGSNKHGQLANEAAFLP-VPQKIEAHCFQ 263
Query: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQ-----------PIPRRVT 199
N++V + G H + T G++F WG + GQ+G + P R
Sbjct: 264 NEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPN 323
Query: 200 GCLQNKVVVT----IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQ 255
+ +T ++CG +A++ G Y WG+N +G G G N P V AL
Sbjct: 324 SMPSSPHCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALL 382
Query: 256 GIRVQRVACGYAHTLVL 272
V CG H+L L
Sbjct: 383 SSSGLLVGCGAGHSLAL 399
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/203 (24%), Positives = 85/203 (41%), Gaps = 26/203 (12%)
Query: 32 PIFSLCSEEE----LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI 87
P+F E L+ + CV + + T E++V G+N G L +
Sbjct: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG-EVYVWGSNKHGQLA-NEAAFLP 252
Query: 88 EPRRLDS--LNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNH------- 138
P+++++ +K+ + + H+V T G++FTWG Y QLG +
Sbjct: 253 VPQKIEAHCFQNEKVTAI-WSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEK 311
Query: 139 --GLVPCHISTNLSNKQ------VIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTV 190
+PC N EV+CGS H+L + G ++WG+N G G G+
Sbjct: 312 QDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEA 370
Query: 191 NQPIPRRVTGCLQNKVVVTIACG 213
N P+ V L + ++ + CG
Sbjct: 371 NVWAPKPVQALLSSSGLL-VGCG 392
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 102 bits (254), Expect = 9e-22
Identities = 57/161 (35%), Positives = 90/161 (55%), Gaps = 2/161 (1%)
Query: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGE 172
L+ E VF+WG + +LG G + +P +I L+ + V ++ CG+ L LT G
Sbjct: 18 LSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIE-RLNGQGVCQIECGAQFLLALTKSGV 76
Query: 173 VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232
V+ WG + ++G S V+ P+ V G L+ K +V +A G C+AV+D+G+VY WG N
Sbjct: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN 135
Query: 233 GNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273
+GQ G G + P V L+G ++ VACG +H++ T
Sbjct: 136 DHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 89.4 bits (220), Expect = 8e-18
Identities = 53/154 (34%), Positives = 78/154 (50%), Gaps = 1/154 (0%)
Query: 173 VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232
VF+WG + G++G G + IP+ + L + V I CG +A+ +G V+ WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 233 GNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292
+LG + + P V L+G ++ VA G H L + D GQVYAWG N +GQ G G
Sbjct: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
Query: 293 NKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
+ PT V + + I AC S+H+ A T
Sbjct: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
Score = 82.8 bits (203), Expect = 7e-16
Identities = 47/147 (31%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+F G G LG G + P+ ++ LNG+ + + G+ ++ T G V+TWG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKG 83
Query: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186
Y +LG+ + H P + L K+++ VA G+ H L + G+V+AWG N+ GQ G+
Sbjct: 84 DYFRLGHRSDVHVRKP-QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Query: 187 GSTVNQPIPRRVTGCLQNKVVVTIACG 213
G+T P V G L+ + ++ +ACG
Sbjct: 143 GTTTVNRKPTLVQG-LEGQKIMCVACG 168
Score = 55.8 bits (133), Expect = 1e-07
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 2/82 (2%)
Query: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
+P+ ++ L GKKI ++ G+ H + G+V+ WG N + Q GNGTT P +
Sbjct: 98 KPQVVEGLRGKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ- 155
Query: 148 NLSNKQVIEVACGSYHSLVLTS 169
L ++++ VACGS HS+ T+
Sbjct: 156 GLEGQKIMCVACGSSHSVAWTT 177
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/110 (31%), Positives = 47/110 (42%), Gaps = 1/110 (0%)
Query: 226 VYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANS 285
V+ WG G+LG G S P + L G V ++ CG L LT G V+ WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 286 YGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Y +LG + + P V + + I A + H A G VY WG
Sbjct: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWG 133
Score = 33.5 bits (75), Expect = 0.52
Identities = 22/99 (22%), Positives = 41/99 (41%), Gaps = 10/99 (10%)
Query: 29 GKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTV----------NDEIFVLGTNCCGCL 78
GK F L ++ + + V G G ++++ V + +++ G N G
Sbjct: 81 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 140
Query: 79 GLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTE 117
G G +P + L G+KI C++ GS + T +
Sbjct: 141 GNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVD 179
Score = 29.6 bits (65), Expect = 7.5
Identities = 17/65 (26%), Positives = 28/65 (43%), Gaps = 7/65 (10%)
Query: 275 EGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACH---STHTSAAKTQGGHV 331
E V++WG +G+LG G + P + +R+ C A T+ G V
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNI----ERLNGQGVCQIECGAQFLLALTKSGVV 77
Query: 332 YMWGQ 336
+ WG+
Sbjct: 78 WTWGK 82
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 102 bits (254), Expect = 9e-22
Identities = 56/156 (35%), Positives = 88/156 (56%), Gaps = 2/156 (1%)
Query: 118 GEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG 177
G VF+WG + +LG G + +P +I L+ + V ++ CG+ L LT G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIE-RLNGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 178 YNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQL 237
+ ++G S V+ P+ V G L+ K +V +A G C+AV+D+G+VY WG N +GQ
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 238 GLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273
G G + P V L+G ++ VACG +H++ T
Sbjct: 793 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 88.2 bits (217), Expect = 2e-17
Identities = 53/156 (33%), Positives = 78/156 (50%), Gaps = 1/156 (0%)
Query: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
G VF+WG + G++G G + IP+ + L + V I CG +A+ +G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+LG + + P V L+G ++ VA G H L + D GQVYAWG N +GQ G
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 793
Query: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
G + P V + + I AC S+H+ A T
Sbjct: 794 NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 829
Score = 83.2 bits (204), Expect = 6e-16
Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 15/186 (8%)
Query: 28 VGKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI 87
VG W S + + C G +F G G LG G +
Sbjct: 650 VGNWEYISTGKVSDNYALLTKCEMGGL------------VFSWGDGDFGKLGRGGSEGCN 697
Query: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
P+ ++ LNG+ + + G+ ++ T G V+TWG Y +LG+ + H P +
Sbjct: 698 IPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKP-QVVE 755
Query: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207
L K+++ VA G+ H L + G+V+AWG N+ GQ G+G+T P V G L+ + +
Sbjct: 756 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQG-LEGQKI 814
Query: 208 VTIACG 213
+ +ACG
Sbjct: 815 MCVACG 820
Score = 55.8 bits (133), Expect = 1e-07
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 2/82 (2%)
Query: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
+P+ ++ L GKKI ++ G+ H + G+V+ WG N + Q GNGTT P +
Sbjct: 750 KPQVVEGLRGKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQ- 807
Query: 148 NLSNKQVIEVACGSYHSLVLTS 169
L ++++ VACGS HS+ T+
Sbjct: 808 GLEGQKIMCVACGSSHSVAWTT 829
Score = 55.5 bits (132), Expect = 1e-07
Identities = 36/112 (32%), Positives = 48/112 (42%), Gaps = 1/112 (0%)
Query: 224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA 283
G V+ WG G+LG G S P + L G V ++ CG L LT G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 284 NSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Y +LG + + P V + + I A + H A G VY WG
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWG 785
Score = 33.1 bits (74), Expect = 0.68
Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 11/98 (11%)
Query: 29 GKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTV----------NDEIFVLGTNCCGCL 78
GK F L ++ + + V G G ++++ V + +++ G N G
Sbjct: 733 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 79 GLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATT 116
G G +P + L G+KI C++ GS H V TT
Sbjct: 793 GNGTTTVNRKPMLVQGLEGQKIMCVACGSS-HSVAWTT 829
Score = 30.8 bits (68), Expect = 3.4
Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 7/83 (8%)
Query: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316
I +V+ YA G V++WG +G+LG G + P + +R+ C
Sbjct: 656 ISTGKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNI----ERLNGQGVC 711
Query: 317 H---STHTSAAKTQGGHVYMWGQ 336
A T+ G V+ WG+
Sbjct: 712 QIECGAQFLLALTKSGVVWTWGK 734
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 101 bits (251), Expect = 2e-21
Identities = 95/367 (25%), Positives = 164/367 (44%), Gaps = 38/367 (10%)
Query: 1 MEEELPLFSGDSGKPVQATLSSLKML-------DVGKWPIFSLCSEEELQLIRQACVFGS 53
MEE++ L + + +P +T++ + +V W + ++L +I+ C
Sbjct: 315 MEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWG-GGKSTPQKLDVIKSGCSARQ 373
Query: 54 --AGN-EVLYTTVNDEIFVL-----GTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSY 105
AGN TV E++ GT G LG GD S +P+ ++ L GK I +S
Sbjct: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSC 433
Query: 106 GSGPHIVLATTEGEVFTWGHNAYSQLG--NGTTNHGLVPCHISTNLSNKQVIEVACGSYH 163
G V T EG+++ +G + Y +G L P ++ LSN V +V+CG H
Sbjct: 434 GD-DFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN-PVEQVSCGDNH 491
Query: 164 SLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDT 223
+VLT + EV++WG G++G S + P++V + ++V + CG + +
Sbjct: 492 VVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKV-DVPKALIIVAVQCGCDGTFLLTQS 550
Query: 224 GEVYVWGYNGNGQLGL--------GNSGNQPTPCRVA-----ALQGIRVQRVACGYAHTL 270
G+V G N +LGL + P + L +++ +A G HT
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
Query: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV--TVEKDRIIEIAACHSTHTSAAKTQG 328
+ + G++ +G N GQLG GN + + + ++I + +C T AA T
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV-SCGDEFTIAA-TDD 668
Query: 329 GHVYMWG 335
H++ WG
Sbjct: 669 NHIFAWG 675
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/282 (25%), Positives = 127/282 (45%), Gaps = 25/282 (8%)
Query: 62 TVNDEIFVLGTNCCGCLGLGDVQS--TIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGE 119
T +++ G++ GC+G+ V +EP +L+ + +S G H+V+ T E
Sbjct: 442 TDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDN-HVVVLTRNKE 500
Query: 120 VFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 179
V++WG Y +LG + P + + ++ V CG + +LT G+V A G N
Sbjct: 501 VYSWGCGEYGRLGLDSEEDYYTPQKVDVPKA-LIIVAVQCGCDGTFLLTQSGKVLACGLN 559
Query: 180 NSGQVGSGSTVN--------QPIPRRVTGCLQNKV----VVTIACGQMCCMAVVDTGEVY 227
++G ++ +P + L ++ + TIA G+ A+ + G +
Sbjct: 560 EFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLL 619
Query: 228 VWGYNGNGQLGLGNSGNQPTPCRVAA-LQGIRVQRVACGYAHTLVLTDEGQVYAWGANSY 286
+G N GQLG+GN + + L G +V RV+CG T+ TD+ ++AWG
Sbjct: 620 TFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGN 679
Query: 287 GQLGT-------GNKSNQSYPTPVTVEKDRIIEIAACHSTHT 321
G+L G+ S+P P+ + ++ +C HT
Sbjct: 680 GRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDL-SCRGWHT 720
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/196 (27%), Positives = 88/196 (44%), Gaps = 13/196 (6%)
Query: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLAT 115
N V+ T N E++ G G LGL + P+++D I + G +L T
Sbjct: 490 NHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL-T 548
Query: 116 TEGEVFTWGHNAYSQLG-----NGTTNHGL---VPCHISTNLSNK----QVIEVACGSYH 163
G+V G N +++LG +G NH VP S L+ + ++ +A G H
Sbjct: 549 QSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTH 608
Query: 164 SLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDT 223
+ + G + +G N GQ+G G+ + + G L K V+ ++CG +A D
Sbjct: 609 TAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDD 668
Query: 224 GEVYVWGYNGNGQLGL 239
++ WG GNG+L +
Sbjct: 669 NHIFAWGNGGNGRLAM 684
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 100 bits (250), Expect = 3e-21
Identities = 80/259 (30%), Positives = 119/259 (45%), Gaps = 20/259 (7%)
Query: 92 LDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP----CHIST 147
LD ++ +S G +VL EG VF+ G+N+Y Q G + + H
Sbjct: 168 LDRPQETRVLQVSCGRAHSLVLTDREG-VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226
Query: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207
+ QV++VACG HSL LT GEV++ G+ GQ G G P ++ G L V
Sbjct: 227 DFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285
Query: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGI-RVQRVACGY 266
+ +A CC+AV G ++ WG + QL Q R G+ +V++ ACG
Sbjct: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGG 345
Query: 267 AHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPV------TVEKDRIIEIA--ACH 317
VL EG V+ WG YG LG G N + P + E + I+++ C
Sbjct: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402
Query: 318 STHTSAAKTQGGHVYMWGQ 336
+H AA T G +++WG+
Sbjct: 403 LSH-FAALTNKGELFVWGK 420
Score = 99.4 bits (246), Expect = 8e-21
Identities = 83/283 (29%), Positives = 135/283 (47%), Gaps = 29/283 (10%)
Query: 40 EELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-----EPRRLDS 94
+E ++++ +C G A + VL T + +F +G N G G V++ I R+
Sbjct: 172 QETRVLQVSC--GRAHSLVL--TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
Query: 95 LNGK--KIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNK 152
+G+ ++AC H + T +GEV++ G A Q G G N P + +L+
Sbjct: 228 FDGQVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
Query: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQP-IPRRVTGCLQNKVVVTI- 210
VI+VA L +++DG +F WG + Q+ S + Q +PR CL V +
Sbjct: 284 NVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVR 339
Query: 211 --ACGQMCCMAVVDTGEVYVWGYN--GNGQLGLGNSGNQPTPCRVAALQG----IRVQRV 262
ACG C + G V+VWGY G G + ++ + P + L I+V R+
Sbjct: 340 QAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399
Query: 263 ACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305
CG +H LT++G+++ WG N G LG G +Q +P VT+
Sbjct: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442
Score = 39.3 bits (90), Expect = 0.009
Identities = 43/154 (27%), Positives = 66/154 (42%), Gaps = 39/154 (25%)
Query: 226 VYVWGYNGNGQLG-----LGNSGN------------QPTPCRVAALQGIRVQRVACGYAH 268
V+VWG++ +G LG + +SG QP P R+ Q ++ ACGY
Sbjct: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQ--KISSAACGYGF 118
Query: 269 TLV---LTDEGQVYAWGANSYGQLG---TGNKSNQSY-----PTPVTVEKDRIIEI---- 313
TL+ D +V+ G N QLG + + Y P+PV++ DR E
Sbjct: 119 TLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQ 178
Query: 314 AACHSTHTSAAKTQGGHVYM----WGQCRGQSVI 343
+C H+ + G M +GQC G+ V+
Sbjct: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQC-GRKVV 211
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 98.6 bits (244), Expect = 1e-20
Identities = 55/156 (35%), Positives = 87/156 (55%), Gaps = 2/156 (1%)
Query: 118 GEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG 177
G VF+WG + +LG G + +P +I L+ + V ++ CG+ L LT G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIE-RLNGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 178 YNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQL 237
+ ++G S V+ + V G L+ K +V +A G C+AV+D+G+VY WG N +GQ
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 238 GLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273
G G + P V L+G ++ VACG +H++ T
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Score = 84.3 bits (207), Expect = 3e-16
Identities = 52/156 (33%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
G VF+WG + G++G G + IP+ + L + V I CG +A+ +G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
+LG + + V L+G ++ VA G H L + D GQVYAWG N +GQ G
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 843
Query: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
G + P V + + I AC S+H+ A T
Sbjct: 844 NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 879
Score = 81.6 bits (200), Expect = 2e-15
Identities = 52/186 (27%), Positives = 86/186 (46%), Gaps = 15/186 (8%)
Query: 28 VGKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI 87
VG W S + + C G +F G G LG G +
Sbjct: 700 VGNWEYISTGKVSDNYALLTKCEMGGL------------VFSWGDGDFGKLGRGGSEGCN 747
Query: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
P+ ++ LNG+ + + G+ ++ T G V+TWG Y +LG+ + H + +
Sbjct: 748 IPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKGDYFRLGHRSDVH-VRKLQVVE 805
Query: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207
L K+++ VA G+ H L + G+V+AWG N+ GQ G+G+T P V G L+ + +
Sbjct: 806 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQG-LEGQKI 864
Query: 208 VTIACG 213
+ +ACG
Sbjct: 865 MCVACG 870
Score = 53.9 bits (128), Expect = 4e-07
Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 5/89 (5%)
Query: 84 QSTIEPRRL---DSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGL 140
+S + R+L + L GKKI ++ G+ H + G+V+ WG N + Q GNGTT
Sbjct: 793 RSDVHVRKLQVVEGLRGKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNR 851
Query: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTS 169
P + L ++++ VACGS HS+ T+
Sbjct: 852 KPMLVQ-GLEGQKIMCVACGSSHSVAWTT 879
Score = 32.7 bits (73), Expect = 0.89
Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 11/98 (11%)
Query: 29 GKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTV----------NDEIFVLGTNCCGCL 78
GK F L ++ + + V G G ++++ V + +++ G N G
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 79 GLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATT 116
G G +P + L G+KI C++ GS H V TT
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGSS-HSVAWTT 879
Score = 30.8 bits (68), Expect = 3.4
Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 7/83 (8%)
Query: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316
I +V+ YA G V++WG +G+LG G + P + +R+ C
Sbjct: 706 ISTGKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNI----ERLNGQGVC 761
Query: 317 H---STHTSAAKTQGGHVYMWGQ 336
A T+ G V+ WG+
Sbjct: 762 QIECGAQFLLALTKSGVVWTWGK 784
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 90.5 bits (223), Expect = 4e-18
Identities = 74/253 (29%), Positives = 117/253 (46%), Gaps = 25/253 (9%)
Query: 70 LGTNCCGCLGLGDVQSTI-----EPRRLDSLNGK--KIACLSYGSGPHIVLATTEGEVFT 122
+G N G G V++ I R+ +G+ ++AC H + T +GEV++
Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVAC----GQDHSLFLTDKGEVYS 56
Query: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182
G A Q G G N P + +L+ VI+VA L +++DG +F WG +
Sbjct: 57 CGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTI---ACGQMCCMAVVDTGEVYVWGYN--GNGQ 236
Q+ S + Q +PR CL V + ACG C + G V+VWGY G G
Sbjct: 117 QLASVTDSTQVNVPR----CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGP 172
Query: 237 LGLGNSGNQPTPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292
+ ++ + P + L I+V R+ CG + LT++G+++ WG N G LG G
Sbjct: 173 NLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIG 232
Query: 293 NKSNQSYPTPVTV 305
+Q +P VT+
Sbjct: 233 RLEDQYFPWRVTM 245
Score = 89.0 bits (219), Expect = 1e-17
Identities = 68/226 (30%), Positives = 101/226 (44%), Gaps = 17/226 (7%)
Query: 124 GHNAYSQLGNGTTNHGLVP----CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 179
G+N+Y Q G + + H + QV++VACG HSL LT GEV++ G+
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 180 NSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGL 239
GQ G G P ++ G L V+ +A CC+AV G ++ WG + QL
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 240 GNSGNQPTPCRVAALQGI-RVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQ 297
Q R G+ +V++ ACG VL EG V+ WG YG LG G N
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVES 177
Query: 298 SYPTPV------TVEKDRIIEIAACH-STHTSAAKTQGGHVYMWGQ 336
+ P + E + I+++ AA T G +++WG+
Sbjct: 178 AVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
Score = 83.2 bits (204), Expect = 6e-16
Identities = 77/243 (31%), Positives = 109/243 (44%), Gaps = 27/243 (11%)
Query: 43 QLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL--DSLNGKKI 100
Q+++ AC + L+ T E++ G G GLG T P +L D I
Sbjct: 34 QVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVI 89
Query: 101 ACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGT--TNHGLVPC-HISTNLSNKQVIEV 157
+YG + + +G +F WG++ Y QL + T T + C H S +V +
Sbjct: 90 QVATYGD--CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQA 144
Query: 158 ACGSYHSLVLTSDGEVFAWGYNNSGQVGSG-----STVNQPIPRRVTGCLQ---NKVVVT 209
ACG VL +G VF WGY G +G G S V + IP + G + V
Sbjct: 145 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201
Query: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269
I CG A+ + GE++VWG N G LG+G +Q P RV + G V VACG H
Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHM 259
Query: 270 LVL 272
+ L
Sbjct: 260 VTL 262
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 90.5 bits (223), Expect = 4e-18
Identities = 74/253 (29%), Positives = 117/253 (46%), Gaps = 25/253 (9%)
Query: 70 LGTNCCGCLGLGDVQSTI-----EPRRLDSLNGK--KIACLSYGSGPHIVLATTEGEVFT 122
+G N G G V++ I R+ +G+ ++AC H + T +GEV++
Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVAC----GQDHSLFLTDKGEVYS 56
Query: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182
G A Q G G N P + +L+ VI+VA L +++DG +F WG +
Sbjct: 57 CGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTI---ACGQMCCMAVVDTGEVYVWGYN--GNGQ 236
Q+ S + Q +PR CL V + ACG C + G V+VWGY G G
Sbjct: 117 QLASVTDSTQVNVPR----CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGP 172
Query: 237 LGLGNSGNQPTPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292
+ ++ + P + L I+V R+ CG + LT++G+++ WG N G LG G
Sbjct: 173 NLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIG 232
Query: 293 NKSNQSYPTPVTV 305
+Q +P VT+
Sbjct: 233 RLEDQYFPWRVTM 245
Score = 89.0 bits (219), Expect = 1e-17
Identities = 68/226 (30%), Positives = 101/226 (44%), Gaps = 17/226 (7%)
Query: 124 GHNAYSQLGNGTTNHGLVP----CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 179
G+N+Y Q G + + H + QV++VACG HSL LT GEV++ G+
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 180 NSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGL 239
GQ G G P ++ G L V+ +A CC+AV G ++ WG + QL
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 240 GNSGNQPTPCRVAALQGI-RVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQ 297
Q R G+ +V++ ACG VL EG V+ WG YG LG G N
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVES 177
Query: 298 SYPTPV------TVEKDRIIEIAACH-STHTSAAKTQGGHVYMWGQ 336
+ P + E + I+++ AA T G +++WG+
Sbjct: 178 AVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
Score = 83.2 bits (204), Expect = 6e-16
Identities = 77/243 (31%), Positives = 109/243 (44%), Gaps = 27/243 (11%)
Query: 43 QLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL--DSLNGKKI 100
Q+++ AC + L+ T E++ G G GLG T P +L D I
Sbjct: 34 QVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVI 89
Query: 101 ACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGT--TNHGLVPC-HISTNLSNKQVIEV 157
+YG + + +G +F WG++ Y QL + T T + C H S +V +
Sbjct: 90 QVATYGD--CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQA 144
Query: 158 ACGSYHSLVLTSDGEVFAWGYNNSGQVGSG-----STVNQPIPRRVTGCLQ---NKVVVT 209
ACG VL +G VF WGY G +G G S V + IP + G + V
Sbjct: 145 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201
Query: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269
I CG A+ + GE++VWG N G LG+G +Q P RV + G V VACG H
Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHM 259
Query: 270 LVL 272
+ L
Sbjct: 260 VTL 262
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 89.7 bits (221), Expect = 6e-18
Identities = 55/198 (27%), Positives = 90/198 (45%), Gaps = 39/198 (19%)
Query: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215
++ G+ H+L+L + G+VF+WG GQ+G G T+ + R+ LQ V+ +A G
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHG-TLEAELEPRLLEALQGLVMAEVAAGGW 220
Query: 216 CCMAVVDTGEVYVWGYNGNGQLG-------------------LGNSGN------------ 244
+ V +TG++Y+WG+N +GQL L G+
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
Query: 245 -------QPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQ 297
QP P + G + +CG HT V+T G++Y WG YGQLG + ++
Sbjct: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
Query: 298 SYPTPVTVEKDRIIEIAA 315
P V D+ +++ A
Sbjct: 341 DRPRRVEYFVDKQLQVKA 358
Score = 78.2 bits (191), Expect = 2e-14
Identities = 58/206 (28%), Positives = 86/206 (41%), Gaps = 42/206 (20%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
H +L G+VF+WG + QLG+GT L P + L + EVA G +HS+ ++
Sbjct: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSE 227
Query: 170 DGEVFAWGYNNSGQVG--------SGSTVN------------------------------ 191
G+++ WG+N SGQ+ G TV
Sbjct: 228 TGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAV 287
Query: 192 QPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
QP P + V +CG V TGE+Y WG+ GQLG ++ + P RV
Sbjct: 288 QPFP-ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRV 346
Query: 252 AAL--QGIRVQRVACGYAHTLVLTDE 275
+ ++V+ V CG +T V E
Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVE 372
Score = 67.4 bits (163), Expect = 3e-11
Identities = 49/186 (26%), Positives = 80/186 (43%), Gaps = 39/186 (20%)
Query: 66 EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
++F G G LG G +++ +EPR L++L G +A ++ G G H V + G+++ WG
Sbjct: 178 QVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG-GWHSVCVSETGDIYIWGW 236
Query: 126 NAYSQLGNGTTN---HGLVPCHISTNLS-------------------------------- 150
N QL T N G +T L+
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDL 296
Query: 151 --NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKV-V 207
++ +CGS H+ V+T GE++ WG+ GQ+G T + PRRV + ++ V
Sbjct: 297 PMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQV 356
Query: 208 VTIACG 213
+ CG
Sbjct: 357 KAVTCG 362
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 1/89 (1%)
Query: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316
+R +++ G H L+L GQV++WG +GQLG G + P + + ++ A
Sbjct: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAA 217
Query: 317 HSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
H S ++ G +Y+WG + LP
Sbjct: 218 GGWH-SVCVSETGDIYIWGWNESGQLALP 245
Score = 37.4 bits (85), Expect = 0.036
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 89 PRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTN 148
P LD G S GS H + T GE++TWG Y QLG+ T P +
Sbjct: 291 PALLDLPMGSDAVKASCGSR-HTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYF 349
Query: 149 LSNK-QVIEVACGSYHSLV 166
+ + QV V CG +++ V
Sbjct: 350 VDKQLQVKAVTCGPWNTYV 368
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 89.7 bits (221), Expect = 6e-18
Identities = 55/198 (27%), Positives = 90/198 (45%), Gaps = 39/198 (19%)
Query: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215
++ G+ H+L+L + G+VF+WG GQ+G G T+ + R+ LQ V+ +A G
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHG-TLEAELEPRLLEALQGLVMAEVAAGGW 220
Query: 216 CCMAVVDTGEVYVWGYNGNGQLG-------------------LGNSGN------------ 244
+ V +TG++Y+WG+N +GQL L G+
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
Query: 245 -------QPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQ 297
QP P + G + +CG HT V+T G++Y WG YGQLG + ++
Sbjct: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
Query: 298 SYPTPVTVEKDRIIEIAA 315
P V D+ +++ A
Sbjct: 341 DRPRRVEYFVDKQLQVKA 358
Score = 78.2 bits (191), Expect = 2e-14
Identities = 58/206 (28%), Positives = 86/206 (41%), Gaps = 42/206 (20%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
H +L G+VF+WG + QLG+GT L P + L + EVA G +HS+ ++
Sbjct: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSE 227
Query: 170 DGEVFAWGYNNSGQVG--------SGSTVN------------------------------ 191
G+++ WG+N SGQ+ G TV
Sbjct: 228 TGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAV 287
Query: 192 QPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
QP P + V +CG V TGE+Y WG+ GQLG ++ + P RV
Sbjct: 288 QPFP-ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRV 346
Query: 252 AAL--QGIRVQRVACGYAHTLVLTDE 275
+ ++V+ V CG +T V E
Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVE 372
Score = 67.4 bits (163), Expect = 3e-11
Identities = 49/186 (26%), Positives = 80/186 (43%), Gaps = 39/186 (20%)
Query: 66 EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
++F G G LG G +++ +EPR L++L G +A ++ G G H V + G+++ WG
Sbjct: 178 QVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG-GWHSVCVSETGDIYIWGW 236
Query: 126 NAYSQLGNGTTN---HGLVPCHISTNLS-------------------------------- 150
N QL T N G +T L+
Sbjct: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDL 296
Query: 151 --NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKV-V 207
++ +CGS H+ V+T GE++ WG+ GQ+G T + PRRV + ++ V
Sbjct: 297 PMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQV 356
Query: 208 VTIACG 213
+ CG
Sbjct: 357 KAVTCG 362
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 1/89 (1%)
Query: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316
+R +++ G H L+L GQV++WG +GQLG G + P + + ++ A
Sbjct: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAA 217
Query: 317 HSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
H S ++ G +Y+WG + LP
Sbjct: 218 GGWH-SVCVSETGDIYIWGWNESGQLALP 245
Score = 37.4 bits (85), Expect = 0.036
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 89 PRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTN 148
P LD G S GS H + T GE++TWG Y QLG+ T P +
Sbjct: 291 PALLDLPMGSDAVKASCGSR-HTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYF 349
Query: 149 LSNK-QVIEVACGSYHSLV 166
+ + QV V CG +++ V
Sbjct: 350 VDKQLQVKAVTCGPWNTYV 368
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 83.2 bits (204), Expect = 6e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 54 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 111
Query: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 112 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 168
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 169 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 225
Query: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 226 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 285
Query: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Y QLGT + P +T K+
Sbjct: 286 YHQLGTPGTESCFIPQNLTSFKN 308
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 200 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 259
Query: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 260 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 319
Query: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 320 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 377
Query: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 378 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 428
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 289 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 346
Query: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 347 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 405
Query: 196 RRVTG-CLQNKVVVTIACG 213
+ G L+N+VV++++ G
Sbjct: 406 VEMMGKQLENRVVLSVSSG 424
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 50 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 107
Query: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 108 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 165
Query: 340 QSVIL 344
+ ++
Sbjct: 166 NNGVI 170
Score = 30.0 bits (66), Expect = 5.7
Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 263 ACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTVEKDRIIEIAACHSTHT 321
+C +H T+ G V G GQLG G N + P V++ +D + A HT
Sbjct: 39 SCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPED--VVQAEAGGMHT 96
Query: 322 SAAKTQGGHVYMWG 335
++ G VY +G
Sbjct: 97 -VCLSKSGQVYSFG 109
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 83.2 bits (204), Expect = 6e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 68 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 125
Query: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 126 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 182
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 183 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 239
Query: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 240 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 299
Query: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Y QLGT + P +T K+
Sbjct: 300 YHQLGTPGTESCFIPQNLTSFKN 322
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 214 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 273
Query: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 274 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 333
Query: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 334 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 391
Query: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 392 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 442
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 303 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 360
Query: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 361 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 419
Query: 196 RRVTG-CLQNKVVVTIACG 213
+ G L+N+VV++++ G
Sbjct: 420 VEMMGKQLENRVVLSVSSG 438
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 64 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 121
Query: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 122 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 179
Query: 340 QSVIL 344
+ ++
Sbjct: 180 NNGVI 184
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 83.2 bits (204), Expect = 6e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 37 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 95 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 152 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208
Query: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 268
Query: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Y QLGT + P +T K+
Sbjct: 269 YHQLGTPGTESCFIPQNLTSFKN 291
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 183 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 242
Query: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 243 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 302
Query: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 303 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 360
Query: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 411
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 329
Query: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 330 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
Query: 196 RRVTG-CLQNKVVVTIACG 213
+ G L+N+VV++++ G
Sbjct: 389 VEMMGKQLENRVVLSVSSG 407
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 90
Query: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 148
Query: 340 QSVIL 344
+ ++
Sbjct: 149 NNGVI 153
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 83.2 bits (204), Expect = 6e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 37 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 95 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 152 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208
Query: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 268
Query: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Y QLGT + P +T K+
Sbjct: 269 YHQLGTPGTESCFIPQNLTSFKN 291
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 183 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 242
Query: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 243 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 302
Query: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 303 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 360
Query: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 411
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 329
Query: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 330 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
Query: 196 RRVTG-CLQNKVVVTIACG 213
+ G L+N+VV++++ G
Sbjct: 389 VEMMGKQLENRVVLSVSSG 407
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 90
Query: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 148
Query: 340 QSVIL 344
+ ++
Sbjct: 149 NNGVI 153
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 83.2 bits (204), Expect = 6e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 37 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 95 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 152 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208
Query: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 268
Query: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Y QLGT + P +T K+
Sbjct: 269 YHQLGTPGTESCFIPQNLTSFKN 291
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 183 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 242
Query: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 243 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 302
Query: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 303 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 360
Query: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 411
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 329
Query: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 330 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
Query: 196 RRVTG-CLQNKVVVTIACG 213
+ G L+N+VV++++ G
Sbjct: 389 VEMMGKQLENRVVLSVSSG 407
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 90
Query: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 148
Query: 340 QSVIL 344
+ ++
Sbjct: 149 NNGVI 153
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 83.2 bits (204), Expect = 6e-16
Identities = 71/263 (26%), Positives = 120/263 (45%), Gaps = 29/263 (11%)
Query: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
+ LG G LGLG+ + +E ++ ++ + + G H V + G+V+++G N
Sbjct: 37 VLTLGQGDVGQLGLGE--NVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 127 AYSQLGNGTTNHG--LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY--NNSG 182
LG T+ G +VP + ++V++V+ G H+ LT DG VF WG +N+G
Sbjct: 95 DEGALGRDTSVEGSEMVPGKVELQ---EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNG 151
Query: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--- 238
+G + + +P +V + VV +A G + + G++Y G GQLG
Sbjct: 152 VIGLLEPMKKSMVPVQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVP 208
Query: 239 --LGNSGNQP-------TPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANS 285
N G + C + +G +R Q CG T ++ EG VY +G ++
Sbjct: 209 ELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSN 268
Query: 286 YGQLGTGNKSNQSYPTPVTVEKD 308
Y QLGT + P +T K+
Sbjct: 269 YHQLGTPGTESCFIPQNLTSFKN 291
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 21/231 (9%)
Query: 110 HIVLATTEGEVFTWGHNAYSQLGNGT---TNHG--------LVP-CHISTNLSNKQVI-- 155
H+V+ T +G+++T G QLG N G LVP C + + ++ +
Sbjct: 183 HLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRF 242
Query: 156 -EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN-KVVVTIACG 213
+ CG+Y + ++ +G V+ +G +N Q+G+ T + IP+ +T + K V + G
Sbjct: 243 QDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGG 302
Query: 214 QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVL 272
Q + + G+ Y G G+LGLG + + P ++ L V VACG + +
Sbjct: 303 QHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAV 360
Query: 273 TDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE--KDRIIEIAACHSTHT 321
T +G+V+AWG + QLGTG + P + + ++R++ + HT
Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHT 411
Score = 61.2 bits (147), Expect = 2e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 78 LGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPH-IVLATTEGEVFTWGHNAYSQLGNGTT 136
LG +S P+ L S + + + G H V +EG+ ++ G Y +LG G
Sbjct: 272 LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG-- 329
Query: 137 NHGLVPCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
G I T +S + VACG+ +T DG VFAWG + Q+G+G + P
Sbjct: 330 -EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP 388
Query: 196 RRVTG-CLQNKVVVTIACG 213
+ G L+N+VV++++ G
Sbjct: 389 VEMMGKQLENRVVLSVSSG 407
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 222 DTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
+ G V G GQLGLG N + P V+ + + VQ A G HT+ L+ GQVY+
Sbjct: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDV-VQAEAGGM-HTVCLSKSGQVYS 90
Query: 281 WGANSYGQLGTGNKSNQSYPTPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRG 339
+G N G LG S P VE ++++++++A S HT AA T G V++WG R
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS-HT-AALTDDGRVFLWGSFRD 148
Query: 340 QSVIL 344
+ ++
Sbjct: 149 NNGVI 153
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,225,294
Number of Sequences: 37866
Number of extensions: 945432
Number of successful extensions: 2717
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 1853
Number of HSP's gapped (non-prelim): 362
length of query: 551
length of database: 18,247,518
effective HSP length: 107
effective length of query: 444
effective length of database: 14,195,856
effective search space: 6302960064
effective search space used: 6302960064
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.