Search of human proteins with 45243534

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
         (1237 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]       2480   0.0  
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]        2388   0.0  
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]       1294   0.0  
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]       1293   0.0  
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]       1281   0.0  
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ...  1184   0.0  
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...  1181   0.0  
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]       1176   0.0  
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]       1176   0.0  
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        738   0.0  
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        698   0.0  
gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]        697   0.0  
gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]        697   0.0  
gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]        694   0.0  
gi|190194360 protocadherin 20 [Homo sapiens]                          656   0.0  
gi|14589929 protocadherin 18 precursor [Homo sapiens]                 383   e-106
gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precur...   372   e-102
gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precur...   372   e-102
gi|94538350 protocadherin 17 precursor [Homo sapiens]                 370   e-102
gi|157426847 protocadherin 19 isoform a [Homo sapiens]                370   e-102
gi|157426845 protocadherin 19 isoform b [Homo sapiens]                370   e-102
gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precurs...   367   e-101
gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precurs...   367   e-101
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       362   1e-99
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]       362   1e-99
gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs...   362   2e-99
gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur...   362   2e-99
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            354   3e-97
gi|14589880 protocadherin gamma subfamily A, 3 isoform 1 precurs...   353   4e-97
gi|14196465 protocadherin gamma subfamily A, 3 isoform 2 precurs...   353   4e-97

>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score = 2480 bits (6427), Expect = 0.0
 Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)

Query: 1    MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA 60
            MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA
Sbjct: 1    MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA 60

Query: 61   SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN 120
            SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN
Sbjct: 61   SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN 120

Query: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180
            DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE
Sbjct: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180

Query: 181  LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV 240
            LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV
Sbjct: 181  LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV 240

Query: 241  TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
            TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK
Sbjct: 241  TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300

Query: 301  RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL 360
            RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL
Sbjct: 301  RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL 360

Query: 361  RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420
            RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL
Sbjct: 361  RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420

Query: 421  LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480
            LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE
Sbjct: 421  LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480

Query: 481  NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
            NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF
Sbjct: 481  NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540

Query: 541  TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
            TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD
Sbjct: 541  TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600

Query: 601  AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660
            AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK
Sbjct: 601  AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660

Query: 661  VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720
            VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG
Sbjct: 661  VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720

Query: 721  NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
            NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN
Sbjct: 721  NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780

Query: 781  ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH 840
            ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH
Sbjct: 781  ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH 840

Query: 841  ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
            ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI
Sbjct: 841  ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
            NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK
Sbjct: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSD 1020
            HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSD
Sbjct: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSD 1020

Query: 1021 NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI 1080
            NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI
Sbjct: 1021 NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI 1080

Query: 1081 SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD 1140
            SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD
Sbjct: 1081 SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD 1140

Query: 1141 NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS 1200
            NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS
Sbjct: 1141 NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS 1200

Query: 1201 NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL 1237
            NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL
Sbjct: 1201 NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL 1237


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score = 2388 bits (6190), Expect = 0.0
 Identities = 1203/1237 (97%), Positives = 1203/1237 (97%), Gaps = 34/1237 (2%)

Query: 1    MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA 60
            MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA
Sbjct: 1    MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA 60

Query: 61   SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN 120
            SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN
Sbjct: 61   SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN 120

Query: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180
            DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE
Sbjct: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180

Query: 181  LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV 240
            LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV
Sbjct: 181  LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV 240

Query: 241  TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
            TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK
Sbjct: 241  TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300

Query: 301  RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL 360
            RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL
Sbjct: 301  RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL 360

Query: 361  RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420
            RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL
Sbjct: 361  RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420

Query: 421  LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480
            LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE
Sbjct: 421  LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480

Query: 481  NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
            NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF
Sbjct: 481  NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540

Query: 541  TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
            TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD
Sbjct: 541  TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600

Query: 601  AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660
            AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK
Sbjct: 601  AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660

Query: 661  VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720
            VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG
Sbjct: 661  VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720

Query: 721  NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
            NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN
Sbjct: 721  NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780

Query: 781  ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH 840
            ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH
Sbjct: 781  ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH 840

Query: 841  ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
            ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI
Sbjct: 841  ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
            NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK
Sbjct: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSD 1020
            HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQ        
Sbjct: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQ-------- 1012

Query: 1021 NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI 1080
                                      SQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI
Sbjct: 1013 --------------------------SQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI 1046

Query: 1081 SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD 1140
            SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD
Sbjct: 1047 SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD 1106

Query: 1141 NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS 1200
            NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS
Sbjct: 1107 NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS 1166

Query: 1201 NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL 1237
            NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL
Sbjct: 1167 NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL 1203


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 664/1158 (57%), Positives = 863/1158 (74%), Gaps = 33/1158 (2%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+AC+   S  AQE  YTIREE+PENV IG++ KDLN+S I   + T+A + ++L
Sbjct: 8    YIFAVLLACVVFHSG-AQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA-MQFKL 65

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 66   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAG--IPRDEHCFYEVEVAILPDEIFRLV 123

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 124  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 184  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 244  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 304  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLET++ 
Sbjct: 364  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 424  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             LT +SA D DSG NA I Y LGP+A   F LD +TG+LT  +  DRE++++++FT+ A+
Sbjct: 484  QLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN + F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 544  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 604  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PPSN S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 664  VDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 723

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 724  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 783

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R++ E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 784  ELVRKSTEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 841

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++KQ +EW +PN EN+Q    KKKK+KK+ SPK+ LLNFVTIEE+K DD   +  
Sbjct: 842  LKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGN 901

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP++  K
Sbjct: 902  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLN-SK 959

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECS-SQGGFKTKGPLHTRQCNSHSKS 1019
            HH+IQELPLDNTFV  CD++SK SS+SSD +S S+C      F+    +HTR      K 
Sbjct: 960  HHIIQELPLDNTFV-ACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTR---PPMKE 1015

Query: 1020 DNIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTL 1079
                 TP K   ST   I  + +   +SQRRVTFHLP+GSQES SD GLGDH+  GS T 
Sbjct: 1016 VVRSCTPMK--ESTTMEIWIHPQP--QSQRRVTFHLPEGSQESSSDGGLGDHD-AGSLTS 1070

Query: 1080 ISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLA---------EATEMCT 1130
             SH LPL  PQ+E++D+A+P  RTE DGNSDP S    G +  A         EA++ CT
Sbjct: 1071 TSHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEASDNCT 1130

Query: 1131 QECLVLGHSDNCWMPPGL 1148
            QECL+ GHSD CWMP  L
Sbjct: 1131 QECLIYGHSDACWMPASL 1148


>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
          Length = 1347

 Score = 1293 bits (3346), Expect = 0.0
 Identities = 661/1162 (56%), Positives = 861/1162 (74%), Gaps = 31/1162 (2%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+AC+   S  AQE  YTIREE+PENV IG++ KDLN+S I   + T+A + ++L
Sbjct: 8    YIFAVLLACVVFHSG-AQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA-MQFKL 65

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 66   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAG--IPRDEHCFYEVEVAILPDEIFRLV 123

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 124  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 184  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 244  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 304  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLET++ 
Sbjct: 364  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 424  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             LT +SA D DSG NA I Y LGP+A   F LD +TG+LT  +  DRE++++++FT+ A+
Sbjct: 484  QLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN + F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 544  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 604  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PPSN S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 664  VDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 723

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 724  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 783

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R++ E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 784  ELVRKSTEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 841

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++KQ +EW +PN EN+Q    KKKK+KK+ SPK+ LLNFVTIEE+K DD   +  
Sbjct: 842  LKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGN 901

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP++  K
Sbjct: 902  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLN-SK 959

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECS-SQGGFKTKGPLHTRQCNSHSKS 1019
            HH+IQELPLDNTFV  CD++SK SS+SSD +S S+C      F+    +HTR        
Sbjct: 960  HHIIQELPLDNTFV-ACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPPMKEVVR 1018

Query: 1020 DNIPVTPQKCPSSTGFHIQENEESH----YESQRRVTFHLPDGSQESCSDSGLGDHEPVG 1075
               P+  +        H Q   +S      +SQRRVTFHLP+GSQES SD GLGDH+  G
Sbjct: 1019 SCTPM-KESTTMEIWIHPQPQRKSEGKVAGKSQRRVTFHLPEGSQESSSDGGLGDHD-AG 1076

Query: 1076 SGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLA---------EAT 1126
            S T  SH LPL  PQ+E++D+A+P  RTE DGNSDP S    G +  A         EA+
Sbjct: 1077 SLTSTSHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEAS 1136

Query: 1127 EMCTQECLVLGHSDNCWMPPGL 1148
            + CTQECL+ GHSD CWMP  L
Sbjct: 1137 DNCTQECLIYGHSDACWMPASL 1158


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score = 1281 bits (3314), Expect = 0.0
 Identities = 653/1155 (56%), Positives = 854/1155 (73%), Gaps = 56/1155 (4%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+ C+   S  AQE  YTIREE+PENV IGN+ KDLN+S I   + T+ ++ ++L
Sbjct: 40   YIFAVLLVCVVFHSG-AQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTT-TMQFKL 97

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 98   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIP--RDEHCFYEVEVAILPDEIFRLV 155

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 156  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 215

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 216  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 275

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 276  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 335

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 336  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 395

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLE ++ 
Sbjct: 396  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 455

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 456  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 515

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             L  +SATD DSG NA+I Y LGP+A   F LDR+TG+LT  +  DRE++++++FT+ A+
Sbjct: 516  QLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN ++F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 576  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS 635

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 636  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 695

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PP N S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 696  VDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 755

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 756  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 815

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R+++E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 816  ELVRKSIEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 873

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++ Q +EW +PN EN+Q    KKKK+KK+ SPK+ LLN VTIEE+K DD   +  
Sbjct: 874  LKAAQKNMQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGN 933

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP+++ K
Sbjct: 934  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNL-K 991

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSD 1020
            HH+IQELPLDNTFV  CD++S  SS+SSD +S S+C                        
Sbjct: 992  HHIIQELPLDNTFV-ACDSISNCSSSSSDPYSVSDC------------------------ 1026

Query: 1021 NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI 1080
              PVT  + P S   H +        SQRRVTFHLP+GSQES SD GLGDH+  GS T  
Sbjct: 1027 GYPVTTFEVPVSV--HTR-------PSQRRVTFHLPEGSQESSSDGGLGDHD-AGSLTST 1076

Query: 1081 SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPR-------GLAEATEMCTQEC 1133
            SH LPL  PQ+E++D+A+P  RTE DGNSDP S    G +        + EA++ CTQEC
Sbjct: 1077 SHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKEITVQPTVEEASDNCTQEC 1136

Query: 1134 LVLGHSDNCWMPPGL 1148
            L+ GHSD CWMP  L
Sbjct: 1137 LIYGHSDACWMPASL 1151


>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
            sapiens]
          Length = 1025

 Score = 1184 bits (3062), Expect = 0.0
 Identities = 594/1023 (58%), Positives = 782/1023 (76%), Gaps = 16/1023 (1%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+AC+   S  AQE  YTIREE+PENV IG++ KDLN+S I   + T+A + ++L
Sbjct: 8    YIFAVLLACVVFHSG-AQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA-MQFKL 65

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 66   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIP--RDEHCFYEVEVAILPDEIFRLV 123

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 124  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 184  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 244  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 304  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLET++ 
Sbjct: 364  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 424  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             LT +SA D DSG NA I Y LGP+A   F LD +TG+LT  +  DRE++++++FT+ A+
Sbjct: 484  QLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN + F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 544  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 604  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PPSN S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 664  VDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 723

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 724  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 783

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R++ E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 784  ELVRKSTEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 841

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++KQ +EW +PN EN+Q    KKKK+KK+ SPK+ LLNFVTIEE+K DD   +  
Sbjct: 842  LKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGN 901

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP++  K
Sbjct: 902  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLN-SK 959

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECS-SQGGFKTKGPLHTRQCNSHSKS 1019
            HH+IQELPLDNTFV  CD++SK SS+SSD +S S+C      F+    +HTR  +S + +
Sbjct: 960  HHIIQELPLDNTFV-ACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPTDSRTST 1018

Query: 1020 DNI 1022
              I
Sbjct: 1019 IEI 1021


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
            sapiens]
          Length = 1021

 Score = 1181 bits (3056), Expect = 0.0
 Identities = 592/1012 (58%), Positives = 777/1012 (76%), Gaps = 16/1012 (1%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+AC+   S  AQE  YTIREE+PENV IG++ KDLN+S I   + T+A + ++L
Sbjct: 8    YIFAVLLACVVFHSG-AQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA-MQFKL 65

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 66   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIP--RDEHCFYEVEVAILPDEIFRLV 123

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 124  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 184  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 243

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 244  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 304  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLET++ 
Sbjct: 364  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 424  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             LT +SA D DSG NA I Y LGP+A   F LD +TG+LT  +  DRE++++++FT+ A+
Sbjct: 484  QLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN + F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 544  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 604  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PPSN S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 664  VDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 723

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 724  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 783

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R++ E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 784  ELVRKSTEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 841

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++KQ +EW +PN EN+Q    KKKK+KK+ SPK+ LLNFVTIEE+K DD   +  
Sbjct: 842  LKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGN 901

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP++  K
Sbjct: 902  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLN-SK 959

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECS-SQGGFKTKGPLHTR 1011
            HH+IQELPLDNTFV  CD++SK SS+SSD +S S+C      F+    +HTR
Sbjct: 960  HHIIQELPLDNTFV-ACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTR 1010


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score = 1176 bits (3043), Expect = 0.0
 Identities = 588/1018 (57%), Positives = 779/1018 (76%), Gaps = 16/1018 (1%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+ C+   S  AQE  YTIREE+PENV IGN+ KDLN+S I   + T+ ++ ++L
Sbjct: 40   YIFAVLLVCVVFHSG-AQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTT-TMQFKL 97

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 98   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIP--RDEHCFYEVEVAILPDEIFRLV 155

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 156  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 215

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 216  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 275

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 276  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 335

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 336  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 395

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLE ++ 
Sbjct: 396  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 455

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 456  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 515

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             L  +SATD DSG NA+I Y LGP+A   F LDR+TG+LT  +  DRE++++++FT+ A+
Sbjct: 516  QLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN ++F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 576  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS 635

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 636  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 695

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PP N S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 696  VDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 755

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 756  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 815

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R+++E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 816  ELVRKSIEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 873

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++ Q +EW +PN EN+Q    KKKK+KK+ SPK+ LLN VTIEE+K DD   +  
Sbjct: 874  LKAAQKNMQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGN 933

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP+++ K
Sbjct: 934  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNL-K 991

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECS-SQGGFKTKGPLHTRQCNSHS 1017
            HH+IQELPLDNTFV  CD++S  SS+SSD +S S+C      F+    +HTR  +S +
Sbjct: 992  HHIIQELPLDNTFV-ACDSISNCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPTDSRT 1048


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score = 1176 bits (3043), Expect = 0.0
 Identities = 588/1018 (57%), Positives = 779/1018 (76%), Gaps = 16/1018 (1%)

Query: 7    YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
            Y+ A L+ C+   S  AQE  YTIREE+PENV IGN+ KDLN+S I   + T+ ++ ++L
Sbjct: 29   YIFAVLLVCVVFHSG-AQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTT-TMQFKL 86

Query: 67   VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
            V K GD PL+++   TGEIFTT  RIDREKLCAG     +  CF+E+EV ILP++ FRL+
Sbjct: 87   VYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIP--RDEHCFYEVEVAILPDEIFRLV 144

Query: 127  KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            KI+ +++D NDNAP+FP+ VINISIPEN+ INS++ +P+A DPD G NGVQ+YEL+  Q+
Sbjct: 145  KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 204

Query: 187  VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            +FGLD++ETPEG+K PQLIVQ+ LDRE+KDTYVMK+KVEDGG PQ+SSTAILQV+V+D N
Sbjct: 205  IFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTN 264

Query: 247  DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
            DN PVFKE ++EV IPENAPVGTSV QLHATDADIG NA+I + F   V+   +RLF LN
Sbjct: 265  DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 324

Query: 307  NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
             TTGLIT++  LDREET  HK+ VLASDG   PARA V +NVTDVNDN P+ID+RYI++P
Sbjct: 325  ATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNP 384

Query: 367  INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
            +N TV LSE  P+NTKIALITV+DKD D NG+V CF + E+PF L+ V+ NQ+LLE ++ 
Sbjct: 385  VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY 444

Query: 427  LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
            LDYE TKE++ K++A+D+GKP LNQ+A++ +K++DENDN P+F Q  + +S+ ENN  G+
Sbjct: 445  LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 504

Query: 487  YLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTAR 545
             L  +SATD DSG NA+I Y LGP+A   F LDR+TG+LT  +  DRE++++++FT+ A+
Sbjct: 505  QLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 564

Query: 546  DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
            DNG PPL S   V V+++D+NDNSP FTHN ++F+V ENLP++ TVG+ITVTD D G+N 
Sbjct: 565  DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS 624

Query: 606  AVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            AVTLSIL++ND+F +D  +GVI+ N+SFDRE+Q SYTF VKA DGG+  RSS+AKVTINV
Sbjct: 625  AVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINV 684

Query: 666  MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL 725
            +DVNDN PV I PP N S++LV  S  PG+VV +V AVD DTGMNAE++Y+IV GN + L
Sbjct: 685  VDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 744

Query: 726  FRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIY 785
            F ID  TGNITL EK   TD+GLHR++V  +DLG P SL ++V+V L+VN++  NA+ I 
Sbjct: 745  FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLIN 804

Query: 786  DLIRRTMETPLDRN--IGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASR 843
            +L+R+++E P+  N  I D S P    DY+ I++A +AG + V+VVIF+T +VRCR A  
Sbjct: 805  ELVRKSIEAPVTPNTEIADVSSP--TSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPH 862

Query: 844  FKAAQRSKQGAEWMSPNQENKQ---NKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI 900
             KAAQ++ Q +EW +PN EN+Q    KKKK+KK+ SPK+ LLN VTIEE+K DD   +  
Sbjct: 863  LKAAQKNMQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGN 922

Query: 901  NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK 960
              T+ LP +LEEQ++G+++W    PTTFKP+SPDLA+HYKSASPQPAF ++P+TP+++ K
Sbjct: 923  RVTLDLPIDLEEQTMGKYNW-VTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNL-K 980

Query: 961  HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECS-SQGGFKTKGPLHTRQCNSHS 1017
            HH+IQELPLDNTFV  CD++S  SS+SSD +S S+C      F+    +HTR  +S +
Sbjct: 981  HHIIQELPLDNTFV-ACDSISNCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPTDSRT 1037


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  738 bits (1905), Expect = 0.0
 Identities = 476/1197 (39%), Positives = 658/1197 (54%), Gaps = 116/1197 (9%)

Query: 8    LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67
            +L AL+  L      A  ++Y + EE P N  IG++  D     +          +Y+L 
Sbjct: 42   MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH--------LYKL- 92

Query: 68   SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI---LPNDFFR 124
             + G AP ++V   TG+IFTT   IDRE L    +    + C  E EV I   + N   R
Sbjct: 93   -EVG-APYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR 150

Query: 125  LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184
            L++ +I V+D NDN P F SPVI ++IPENT I S FPIP A+D D G NGV  YEL  G
Sbjct: 151  LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG 210

Query: 185  ---QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
               Q +FGL + E  E EK PQLIV  NLDRE+ D+Y + IKV+DGG+P ++S+A+L+VT
Sbjct: 211  PEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269

Query: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
            V D NDN P F+    E  + EN+P+G SVIQ+ A D+D G+NAEI Y F  Q     +R
Sbjct: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH-QAPEVVRR 328

Query: 302  LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNID 359
            L  L+  TGLITVQ  +DRE+ +  + +VLA D  + P  ARA V + V D+NDN P I+
Sbjct: 329  LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388

Query: 360  LRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417
            +R I  ++  +G   +SE     T +AL+ VSD+D   N  V C +  +VPF L+   + 
Sbjct: 389  IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448

Query: 418  ------QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471
                  +Y L+T++ LDYE  K+++ +IVA DSG P L+ T  ++V++ D NDN P+F Q
Sbjct: 449  GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508

Query: 472  PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---FFDLDRKTGVLTASR 528
             V E++  ENN+ G  +  I+A+D DSG NA++VY L P  +    F +  +TG +    
Sbjct: 509  SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKT 568

Query: 529  VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588
              DRE++E +   V A D G+P LQ  A V+V VLD NDN PKF  + + F V EN+P  
Sbjct: 569  SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628

Query: 589  STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
            S VG++TV D D GEN  V LS+  DN +FV+   +G I S++SFDREQQS+YTF +KA 
Sbjct: 629  SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688

Query: 649  DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708
            DGG PPRS+   VTINV+D NDN+P  I+ PSNTS KL+      G  V++V A D D+G
Sbjct: 689  DGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747

Query: 709  MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
            +NAEL Y+I  GN  GLF+I   +G ITLE++      GLHRLVV +SD G P    T  
Sbjct: 748  VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGT-A 806

Query: 769  LVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIV 828
            LV LYVN+T  N + +  L+  +++TPLD +I    +  +++    I+  ++AG + V +
Sbjct: 807  LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866

Query: 829  VIFVTVLVR-CRH---ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNF 884
            +I + VLVR CR     S ++A ++  +      P+ +  +  K K KK KSPK      
Sbjct: 867  LIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKP----- 921

Query: 885  VTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASP 944
            V   E + +  + + +   +   A  +   I         P  + P SPDL +HY+S SP
Sbjct: 922  VKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHL-------PLNYPPGSPDLGRHYRSNSP 974

Query: 945  QPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKT 1004
             P+  L+P +P + KKH V+Q+LP  NTFVG  DT S  S   SD+           ++T
Sbjct: 975  LPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY----------SYRT 1024

Query: 1005 KGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEESHYESQRRVTF-------HLPD 1057
                                 P K PS    H            RRVTF        L D
Sbjct: 1025 --------------------NPPKYPSKQLPH------------RRVTFSATSQAQELQD 1052

Query: 1058 GSQESCSDSGLGDHEPVGSGTLISHPL-PLVQPQDEFYDQASPDKRTEADGN----SDPN 1112
             SQ S  DSGL + E   S +     L PL  P+D +       +RT  DG+      P 
Sbjct: 1053 PSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHY-------ERTTPDGSIGEMEHPE 1105

Query: 1113 SDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKS---PLSTFAPQKE 1166
            +D  L P      T  CT+EC   GHSD CWMP    P +  KS    LSTF P ++
Sbjct: 1106 ND--LRPLPDVAMTGTCTRECSEFGHSDTCWMPGQSSPSRRTKSSALKLSTFVPYQD 1160


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  698 bits (1801), Expect = 0.0
 Identities = 420/1006 (41%), Positives = 589/1006 (58%), Gaps = 50/1006 (4%)

Query: 8    LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67
            +L AL+  L      A  ++Y + EE P N  IG++  D     +          +Y+L 
Sbjct: 42   MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH--------LYKL- 92

Query: 68   SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI---LPNDFFR 124
             + G AP ++V   TG+IFTT   IDRE L    +    + C  E EV I   + N   R
Sbjct: 93   -EVG-APYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR 150

Query: 125  LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184
            L++ +I V+D NDN P F SPVI ++IPENT I S FPIP A+D D G NGV  YEL  G
Sbjct: 151  LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG 210

Query: 185  ---QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
               Q +FGL + E  E EK PQLIV  NLDRE+ D+Y + IKV+DGG+P ++S+A+L+VT
Sbjct: 211  PEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269

Query: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
            V D NDN P F+    E  + EN+P+G SVIQ+ A D+D G+NAEI Y F  Q     +R
Sbjct: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH-QAPEVVRR 328

Query: 302  LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNID 359
            L  L+  TGLITVQ  +DRE+ +  + +VLA D  + P  ARA V + V D+NDN P I+
Sbjct: 329  LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388

Query: 360  LRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417
            +R I  ++  +G   +SE     T +AL+ VSD+D   N  V C +  +VPF L+   + 
Sbjct: 389  IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448

Query: 418  ------QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471
                  +Y L+T++ LDYE  K+++ +IVA DSG P L+ T  ++V++ D NDN P+F Q
Sbjct: 449  GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508

Query: 472  PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---FFDLDRKTGVLTASR 528
             V E++  ENN+ G  +  I+A+D DSG NA++VY L P  +    F +  +TG +    
Sbjct: 509  SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKT 568

Query: 529  VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588
              DRE++E +   V A D G+P LQ  A V+V VLD NDN PKF  + + F V EN+P  
Sbjct: 569  SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628

Query: 589  STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
            S VG++TV D D GEN  V LS+  DN +FV+   +G I S++SFDREQQS+YTF +KA 
Sbjct: 629  SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688

Query: 649  DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708
            DGG PPRS+   VTINV+D NDN+P  I+ PSNTS KL+      G  V++V A D D+G
Sbjct: 689  DGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747

Query: 709  MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
            +NAEL Y+I  GN  GLF+I   +G ITLE++      GLHRLVV +SD G P    T  
Sbjct: 748  VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGT-A 806

Query: 769  LVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIV 828
            LV LYVN+T  N + +  L+  +++TPLD +I    +  +++    I+  ++AG + V +
Sbjct: 807  LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866

Query: 829  VIFVTVLVR-CRH---ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNF 884
            +I + VLVR CR     S ++A ++  +      P+ +  +  K K KK KSPK      
Sbjct: 867  LIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKP----- 921

Query: 885  VTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASP 944
            V   E + +  + + +   +   A  +   I         P  + P SPDL +HY+S SP
Sbjct: 922  VKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHL-------PLNYPPGSPDLGRHYRSNSP 974

Query: 945  QPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDH 990
             P+  L+P +P + KKH V+Q+LP  NTFVG  DT S  S   SD+
Sbjct: 975  LPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020


>gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]
          Length = 1069

 Score =  697 bits (1799), Expect = 0.0
 Identities = 427/1078 (39%), Positives = 606/1078 (56%), Gaps = 98/1078 (9%)

Query: 4    RDFYLLAALIACLRLDSAIAQELI-YTIREELPENVPIGNIPKDLNISHINAATGTSASL 62
            R + L   L+  L L  A A++L+ Y + EE P +V IGN+  DL I      TG S  +
Sbjct: 11   RGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-----VTG-SGEV 64

Query: 63   VYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL--PN 120
             + L S    +  +K+ + TGE+ T+  RIDREKL       +ENECF + EV ++    
Sbjct: 65   TFSLES---GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQ 121

Query: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATD------------ 168
             +  L + ++IV D NDN P FPSPV+ +++ EN  + + + +P+ATD            
Sbjct: 122  SWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYE 181

Query: 169  -------------------------PDTGFNGV---------QHYELLNG---------Q 185
                                     P  G NG          +  +   G          
Sbjct: 182  LLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRS 241

Query: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
            SVF L + +TP+GEK PQLIV+  LDREQ+D+Y + ++V DGG P +SS AIL+V ++DV
Sbjct: 242  SVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDV 301

Query: 246  NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
            NDN P F++   E  + EN+  GT ++QL A D D+G N +I Y+FGA    + +RL  L
Sbjct: 302  NDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESVRRLLRL 360

Query: 306  NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVTDVNDNPPNIDLRYI 363
            + T+G ++V   +DREE    + TV+A D    P   +ATV +N+ D NDN P+I++R I
Sbjct: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420

Query: 364  --ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ--- 418
              I   +G   ++E   V+T IAL+ VSD+D   NG V C +  +VPF LK   D +   
Sbjct: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480

Query: 419  ----YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVI 474
                Y L TS+ LDYE T+EF+  IVA DSG PSL+    + VK+ D NDNPP+F Q V+
Sbjct: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540

Query: 475  ELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDRE 533
            E+   ENN  G  + T+ ATD DSGKNA+I Y L  +    F +D  +G +  + V DRE
Sbjct: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600

Query: 534  EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
            + +R+ F V A+D G P LQ    VIV V D+NDN PKF  + F F+V ENL   S VG+
Sbjct: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660

Query: 594  ITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
            +TV DAD G N  ++L I  +N+ F ++  +G I S +SFDRE Q++YTF VKA DGG P
Sbjct: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720

Query: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
            PRS+TA V++ VMD NDN+P V + P N S+ L+P S+   +VVA V A D D G+NA+L
Sbjct: 721  PRSATATVSLFVMDENDNAPTV-TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADL 779

Query: 714  KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLY 773
             Y+IV GN   LF IDP +G ++L  K      GLHRLVV ++D G P S  T  LV ++
Sbjct: 780  NYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVF 838

Query: 774  VNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVT 833
            VN++  NA+ I   I R++  PL ++I        ++  L+I+I ++AG M VI++I + 
Sbjct: 839  VNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIV 898

Query: 834  VLVR-CRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLL-NFVTIEESK 891
            V+ R CR  ++       K   ++ +P Q +K  K KK KK K  K  L  + VT+E SK
Sbjct: 899  VMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASK 958

Query: 892  PDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLK 951
            P+   ++ +N  +S     +  S+GR+           P SPDLA+HYKS+SP P   L 
Sbjct: 959  PNGQRYDSVNEKLS-----DSPSMGRY-----RSVNGGPGSPDLARHYKSSSPLPTVQLH 1008

Query: 952  PDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLH 1009
            P +P + KKH  +Q+LP  NTFVG  D +    S  SDH S   C +   +  +  LH
Sbjct: 1009 PQSPTAGKKHQAVQDLPPANTFVGAGDNI----SIGSDHCSEYSCQTNNKYSKQMRLH 1062


>gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]
          Length = 1200

 Score =  697 bits (1798), Expect = 0.0
 Identities = 466/1267 (36%), Positives = 668/1267 (52%), Gaps = 116/1267 (9%)

Query: 4    RDFYLLAALIACLRLDSAIAQELI-YTIREELPENVPIGNIPKDLNISHINAATGTSASL 62
            R + L   L+  L L  A A++L+ Y + EE P +V IGN+  DL I      TG S  +
Sbjct: 11   RGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-----VTG-SGEV 64

Query: 63   VYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL--PN 120
             + L S    +  +K+ + TGE+ T+  RIDREKL       +ENECF + EV ++    
Sbjct: 65   TFSLES---GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQ 121

Query: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180
             +  L + ++IV D NDN P FPSPV+ +++ EN  + + + +P+ATD D G NG++ YE
Sbjct: 122  SWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYE 181

Query: 181  LLN--------GQS--VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP 230
            LL         G+S      D    P G             + + D          GGT 
Sbjct: 182  LLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDA-----SEGGGGTN 236

Query: 231  QKSSTAILQVTVSDVNDNRP---VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEI 287
                +++ ++ V+D  D      +  +G  E  + EN+  GT ++QL A D D+G N +I
Sbjct: 237  PGGRSSVFELQVADTPDGEKQPQLIVKGVYEADLAENSAPGTPILQLRAADLDVGVNGQI 296

Query: 288  RYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVT 345
             Y+FGA    + +RL  L+ T+G ++V   +DREE    + TV+A D    P   +ATV 
Sbjct: 297  EYVFGA-ATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVV 355

Query: 346  INVTDVNDNPPNIDLRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI 403
            +N+ D NDN P+I++R I  I   +G   ++E   V+T IAL+ VSD+D   NG V C +
Sbjct: 356  LNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTV 415

Query: 404  EREVPFHLKAVYDNQ-------YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVR 456
              +VPF LK   D +       Y L TS+ LDYE T+EF+  IVA DSG PSL+    + 
Sbjct: 416  VGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLI 475

Query: 457  VKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFF 515
            VK+ D NDNPP+F Q V+E+   ENN  G  + T+ ATD DSGKNA+I Y L  +    F
Sbjct: 476  VKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIF 535

Query: 516  DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHN 575
             +D  +G +  + V DRE+ +R+ F V A+D G P LQ    VIV V D+NDN PKF  +
Sbjct: 536  AIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQD 595

Query: 576  HFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDR 635
             F F+V ENL   S VG++TV DAD G N  ++L I  +N+ F ++  +G I S +SFDR
Sbjct: 596  VFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDR 655

Query: 636  EQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGS 695
            E Q++YTF VKA DGG PPRS+TA V++ VMD NDN+P V + P N S+ L+P S+   +
Sbjct: 656  EHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTV-TLPKNISYTLLPPSSNVRT 714

Query: 696  VVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755
            VVA V A D D G+NA+L Y+IV GN   LF IDP +G ++L  K      GLHRLVV +
Sbjct: 715  VVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQV 774

Query: 756  SDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTI 815
            +D G P S  T  LV ++VN++  NA+ I   I R++  PL ++I        ++  L+I
Sbjct: 775  NDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSI 833

Query: 816  MIAIIAGAMVVIVVIFVTVLVR-CRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKR 874
            +I ++AG M VI++I + V+ R CR  ++       K   ++ +P Q +K  K KK KK 
Sbjct: 834  VIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKN 893

Query: 875  KSPKSSLL-NFVTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSP 933
            K  K  L  + VT+E SKP+   ++ +N  +S     +  S+GR+           P SP
Sbjct: 894  KKSKQPLYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSMGRY-----RSVNGGPGSP 943

Query: 934  DLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSA 993
            DLA+HYKS+SP P   L P +P + KKH  +Q+LP  NTFVG  D +    S  SDH S 
Sbjct: 944  DLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNI----SIGSDHCSE 999

Query: 994  SECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEESHYESQRRVTF 1053
              C +               N +SK     VT         F +    +  ++       
Sbjct: 1000 YSCQTN--------------NKYSKQPFRRVT---------FSVVSQPQDPHQ------- 1029

Query: 1054 HLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNS 1113
                GS +SC DSGL + E   S +     L  +   ++ Y++ +PD   +    S P  
Sbjct: 1030 ----GSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVD----SRPLP 1081

Query: 1114 DGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSP-LSTFAPQKEWVKKDK 1172
            D  L        T  CT+EC   GHSD+CWMP    P +    P LSTF P  E   ++K
Sbjct: 1082 DVAL--------TGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEK 1133

Query: 1173 LVNGHTLTRAWKEDSNRNQFNDR-----KQYGSNEGHFNNGSHMTDIPLANLKSYKQAGG 1227
            L NG     A   D NRN  N +     + + +     N  ++  DIPL     YK +  
Sbjct: 1134 LANGEA---AIMGDRNRNLLNKKLTSSYETFSAASFSKNEEANPEDIPLTKTGEYKPSPV 1190

Query: 1228 ATESPKE 1234
             T + +E
Sbjct: 1191 NTLTRRE 1197


>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
          Length = 1072

 Score =  694 bits (1792), Expect = 0.0
 Identities = 425/1071 (39%), Positives = 603/1071 (56%), Gaps = 98/1071 (9%)

Query: 4    RDFYLLAALIACLRLDSAIAQELI-YTIREELPENVPIGNIPKDLNISHINAATGTSASL 62
            R + L   L+  L L  A A++L+ Y + EE P +V IGN+  DL I      TG S  +
Sbjct: 11   RGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-----VTG-SGEV 64

Query: 63   VYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL--PN 120
             + L S    +  +K+ + TGE+ T+  RIDREKL       +ENECF + EV ++    
Sbjct: 65   TFSLES---GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQ 121

Query: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATD------------ 168
             +  L + ++IV D NDN P FPSPV+ +++ EN  + + + +P+ATD            
Sbjct: 122  SWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYE 181

Query: 169  -------------------------PDTGFNGV---------QHYELLNG---------Q 185
                                     P  G NG          +  +   G          
Sbjct: 182  LLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRS 241

Query: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
            SVF L + +TP+GEK PQLIV+  LDREQ+D+Y + ++V DGG P +SS AIL+V ++DV
Sbjct: 242  SVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDV 301

Query: 246  NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
            NDN P F++   E  + EN+  GT ++QL A D D+G N +I Y+FGA    + +RL  L
Sbjct: 302  NDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESVRRLLRL 360

Query: 306  NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVTDVNDNPPNIDLRYI 363
            + T+G ++V   +DREE    + TV+A D    P   +ATV +N+ D NDN P+I++R I
Sbjct: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420

Query: 364  --ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ--- 418
              I   +G   ++E   V+T IAL+ VSD+D   NG V C +  +VPF LK   D +   
Sbjct: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480

Query: 419  ----YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVI 474
                Y L TS+ LDYE T+EF+  IVA DSG PSL+    + VK+ D NDNPP+F Q V+
Sbjct: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540

Query: 475  ELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDRE 533
            E+   ENN  G  + T+ ATD DSGKNA+I Y L  +    F +D  +G +  + V DRE
Sbjct: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600

Query: 534  EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
            + +R+ F V A+D G P LQ    VIV V D+NDN PKF  + F F+V ENL   S VG+
Sbjct: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660

Query: 594  ITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
            +TV DAD G N  ++L I  +N+ F ++  +G I S +SFDRE Q++YTF VKA DGG P
Sbjct: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720

Query: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
            PRS+TA V++ VMD NDN+P V + P N S+ L+P S+   +VVA V A D D G+NA+L
Sbjct: 721  PRSATATVSLFVMDENDNAPTV-TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADL 779

Query: 714  KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLY 773
             Y+IV GN   LF IDP +G ++L  K      GLHRLVV ++D G P S  T  LV ++
Sbjct: 780  NYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVF 838

Query: 774  VNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVT 833
            VN++  NA+ I   I R++  PL ++I        ++  L+I+I ++AG M VI++I + 
Sbjct: 839  VNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIV 898

Query: 834  VLVR-CRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLL-NFVTIEESK 891
            V+ R CR  ++       K   ++ +P Q +K  K KK KK K  K  L  + VT+E SK
Sbjct: 899  VMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASK 958

Query: 892  PDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLK 951
            P+   ++ +N  +S     +  S+GR+           P SPDLA+HYKS+SP P   L 
Sbjct: 959  PNGQRYDSVNEKLS-----DSPSMGRY-----RSVNGGPGSPDLARHYKSSSPLPTVQLH 1008

Query: 952  PDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGF 1002
            P +P + KKH  +Q+LP  NTFVG  D +    S  SDH S   C +   +
Sbjct: 1009 PQSPTAGKKHQAVQDLPPANTFVGAGDNI----SIGSDHCSEYSCQTNNKY 1055


>gi|190194360 protocadherin 20 [Homo sapiens]
          Length = 951

 Score =  656 bits (1692), Expect = 0.0
 Identities = 364/823 (44%), Positives = 507/823 (61%), Gaps = 36/823 (4%)

Query: 6   FYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNI-----------SHINA 54
           F+L     +CL   S  A EL+Y++ E LP  V IG++ +DL +           S +  
Sbjct: 49  FFLFVGPFSCLGSYSR-ATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPE 107

Query: 55  ATGT--SASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCA------------G 100
            TG   +  L + L S+      V + + +GE+ T++  IDRE LC              
Sbjct: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167

Query: 101 ASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSR 160
            S +  + C   L+V++LP ++FR +K+KI ++D NDNAP FP   I++ +PEN  +N+R
Sbjct: 168 ISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTR 227

Query: 161 FPIPS-ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYV 219
             I   A DPD G NGVQ Y LL+   +F LD+ E   GE+ P LIV   LDRE +D YV
Sbjct: 228 LAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYV 287

Query: 220 MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDA 279
             I  EDGG+P    +A L + +SD+NDN P+F + Q+ V +  NA VGT +  + A D 
Sbjct: 288 SIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDK 347

Query: 280 DIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP 339
           D+G+NA+I Y +  +V  A+K LF L+  TG+I +   +       HK+T+LA+     P
Sbjct: 348 DLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIP 407

Query: 340 ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV 399
           A  T  +++  V   PP I  RYI + I+G VYL E +PVNT IA  T+  +D +   KV
Sbjct: 408 AVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKV 465

Query: 400 ICFIEREVPFHLKAV--YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRV 457
            C+++ E PF L     Y+N+YLLET+  +DYE  + +   +VA +S     +   +++V
Sbjct: 466 NCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKV 523

Query: 458 KLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFD 516
           +L D+NDN PIF QP+IEL++ ENN    +LT + ATD DS +   + Y LGP+A S+F 
Sbjct: 524 QLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 583

Query: 517 LDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576
           LD  TG+LT S   DREE+E++ +TV A D G PP +S A V +TVLD+NDNSP+F +  
Sbjct: 584 LDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKD 643

Query: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636
           F FFV EN P Y  +GVI+VTDADAG N  V LS++N +D FV+D   G++++ VS DRE
Sbjct: 644 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDRE 703

Query: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696
           QQSSYT  V+A DGG+P  SSTAK+TI ++D+NDN P+V+ P SN S+ LV  S +PGS 
Sbjct: 704 QQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSP 763

Query: 697 VAEVFAVDVDTGMNAELKYTIVS--GNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVN 754
           V EV+AVD DTGMNA + Y+I+   G     FRIDP TGNITLEE    TD GLHRL+V 
Sbjct: 764 VTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVK 823

Query: 755 ISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLD 797
           +SD GYP+ LH+ V+V L+VNDT  N SYI  L+R+  E  ++
Sbjct: 824 VSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIE 866


>gi|14589929 protocadherin 18 precursor [Homo sapiens]
          Length = 1135

 Score =  383 bits (984), Expect = e-106
 Identities = 224/664 (33%), Positives = 362/664 (54%), Gaps = 28/664 (4%)

Query: 7   YLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL 66
           ++ A LI     D  + + L Y I EE      I  + +D  ++ +       +++ +R 
Sbjct: 12  FVFALLIVSFNHD-VLGKNLKYRIYEEQRVGSVIARLSED--VADVLLKLPNPSTVRFRA 68

Query: 67  VSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLI 126
           + + G++PL+ V+   GEI +    IDRE+LC      +   C  E +V+ LP +  +L 
Sbjct: 69  MQR-GNSPLLVVNEDNGEI-SIGATIDREQLCQ-----KNLNCSIEFDVITLPTEHLQLF 121

Query: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
            I++ V D NDN+P F   +I I I E+  + +R P+ SA DPD G N +  Y L +   
Sbjct: 122 HIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSL-SAND 180

Query: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
            F +++    +G K+ +LIV + LDRE K +Y +++   D G PQ+S ++IL++++SD N
Sbjct: 181 FFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSN 240

Query: 247 DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
           DN P F++    + + EN+PVGT ++ L+ATD D G+N +I Y F + V+P     F ++
Sbjct: 241 DNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKID 300

Query: 307 NTTGLITVQRSLDREETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRYII 364
           +  G +T+ + +D E T  +++ V A D   +S PA   + I V DVNDN P I++  + 
Sbjct: 301 SERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMS 360

Query: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETS 424
                  Y+ E DP++T +AL+ V DKD+ +NG+++C +     F L+  Y+N YL+ T+
Sbjct: 361 PGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTN 420

Query: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
           + LD E   E+S  ++A D G PSL+      V++ D NDNPP F +   E  +SENN  
Sbjct: 421 ATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSP 480

Query: 485 GLYLTTISATDEDSGKNADIVYQ------LGPN-ASFFDLDRKTGVLTASRVFDREEQER 537
           G Y+TT++ATD D G+N  + Y       LG +  ++  +D   G + A R+FD EE  +
Sbjct: 481 GAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQ 540

Query: 538 FIFTVTARDNGTP-PLQSQAAVIVTVLDENDN-----SPKFTHNHFQFFVSENLPKYSTV 591
             F V ARD G+P  L S   V++T++DENDN      P   +N  +  + +       V
Sbjct: 541 ITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHV 600

Query: 592 GVITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
             I   D D+G N  ++ +I+  N+ + F++DP S  I +NVS D    + +   V   D
Sbjct: 601 TRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQD 660

Query: 650 GGQP 653
            G P
Sbjct: 661 KGNP 664



 Score =  259 bits (662), Expect = 1e-68
 Identities = 275/1002 (27%), Positives = 423/1002 (42%), Gaps = 173/1002 (17%)

Query: 238  LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
            ++V V D+NDN P F    + + I E+A VGT +    A D D+G N+   Y   A    
Sbjct: 123  IEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSAN--- 179

Query: 298  ATKRLFALNNTTGL----ITVQRSLDREETAIHKVTVLASDGSSTPARA---TVTINVTD 350
                +     T G     + V R LDRE  + +++ + ASD    P R+    + I+++D
Sbjct: 180  DFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASD-MGVPQRSGSSILKISISD 238

Query: 351  VNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFH 410
             NDN P  + +  I      + L E  PV T +  +  +D D   NGK++      V   
Sbjct: 239  SNDNSPAFEQQSYI------IQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPK 292

Query: 411  LKAVY---DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPP 467
            +   +     +  L     +DYE TK +   + A D G  S+     + +K+ D NDN P
Sbjct: 293  IMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKP 352

Query: 468  IFNQPVI-----ELS-VSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFF--DLDR 519
              N  ++     E+S + E +    ++  +   D+DSG N +IV +L  +  F       
Sbjct: 353  EININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYE 412

Query: 520  KTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQF 579
               ++  +   DRE++  +  TV A D GTP L +     V + D NDN P F  + ++F
Sbjct: 413  NNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEF 472

Query: 580  FVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVL----------DPYSGVIKS 629
             +SEN    + +  +T TD D GEN  VT +IL   ++F+L          DP +G I +
Sbjct: 473  VISENNSPGAYITTVTATDPDLGENGQVTYTIL---ESFILGSSITTYVTIDPSNGAIYA 529

Query: 630  NVSFDREQQSSYTFDVKATDGGQPPRS-STAKVTINVMDVNDNSPVVISPP--SNTSFKL 686
               FD E+ S  TF V+A DGG P +  S   V + ++D NDN PVVI P   +NT+   
Sbjct: 530  LRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEIT 589

Query: 687  VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDP----VTGNITLEEKPA 742
            +P  A  G  V  + A+D D+G+NAEL   IV+GN + +F IDP    +  N++++  P 
Sbjct: 590  IPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPY 649

Query: 743  PTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGD 802
                    L V I D G P+ LHT VL+   + + A       + +  T  T + +   D
Sbjct: 650  TE----WELSVIIQDKGNPQ-LHTKVLLKCMIFEYA-------ESVTSTAMTSVSQASLD 697

Query: 803  SSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQE 862
             S        + I +  I   ++VI+V+F T   RC         +  K    +     E
Sbjct: 698  VSM------IIIISLGAICAVLLVIMVLFAT---RCN--------REKKDTRSYNCRVAE 740

Query: 863  NKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGP 922
            +      KR  R+  K  +    TI             NGT  LP     +S       P
Sbjct: 741  STYQHHPKRPSRQIHKGDITLVPTI-------------NGT--LPIRSHHRS------SP 779

Query: 923  APPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSK 982
            +       +SP L +    +      H   ++ V++  +HV +   L+ T          
Sbjct: 780  S-------SSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHAT------- 825

Query: 983  RSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEE 1042
                      A E  SQ        LH  Q              Q  PS  G     N+ 
Sbjct: 826  ---------PAVEQVSQ----LLSMLHQGQY-------------QPRPSFRG-----NKY 854

Query: 1043 SHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKR 1102
            S     R   + L D  + S  DSG GD E   S              D    + SP  R
Sbjct: 855  S-----RSYRYALQDMDKFSLKDSGRGDSEAGDS--------------DYDLGRDSPIDR 895

Query: 1103 TEADGNSDPN-SDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTF 1161
               +G SD   +DG +       A  +CT+EC VLGHSD CWMPP   P    +S  + F
Sbjct: 896  LLGEGFSDLFLTDGRI-----PAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRS--NMF 948

Query: 1162 APQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGSNEG 1203
             P +E+  + +  + H   ++ ++D+      ++K+  S  G
Sbjct: 949  IPGEEFPTQPQQQHPH---QSLEDDAQPADSGEKKKSFSTFG 987


>gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precursor
           [Homo sapiens]
          Length = 936

 Score =  372 bits (955), Expect = e-102
 Identities = 231/663 (34%), Positives = 355/663 (53%), Gaps = 42/663 (6%)

Query: 23  AQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSST 82
           A+++ Y+I EEL +   +GNI KDL +     A    A    R+VS+ G   L  ++  +
Sbjct: 32  ARQISYSIPEELEKGSFVGNISKDLGL-----APRELAERGVRIVSR-GRTQLFSLNPRS 85

Query: 83  GEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMF 142
           G + T + RIDRE+LCA ++      C     +++   D  +L  I+I V D NDNAP F
Sbjct: 86  GSLIT-AGRIDREELCAQSA-----RCVVSFNILV--EDRVKLFGIEIEVTDINDNAPKF 137

Query: 143 PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWP 202
            +  +++ I EN     RFP+P A DPD G N +Q Y+L   +  F L +     G K+P
Sbjct: 138 QAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKH-FSLRVQSRANGVKYP 196

Query: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
           +L+++ +LDRE++  + + +   DGG P +S T ++ VTV D NDN PVF   +  V +P
Sbjct: 197 ELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVP 256

Query: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
           EN PVGT ++ + ATD D G+N E+ Y F  +  P T+ L F LN  TG I +  +LD E
Sbjct: 257 ENLPVGTQLLTVTATDRDEGANGEVTYSF--RKLPDTQLLKFQLNKYTGEIKISENLDYE 314

Query: 322 ETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNT 381
           ET  +++ + A DG +  A A V I V DVNDN P + +  + SP+      +E  P+ T
Sbjct: 315 ETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPV------TEDSPLGT 368

Query: 382 KIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVA 441
            +AL+ V D D++ NG+V C I   +PF L+   D+ Y L     LD E    ++  + A
Sbjct: 369 VVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTA 428

Query: 442 SDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKN 501
           +D G P L+  A   +++ D NDNPP F+Q      + ENN RG  + +++A D DS +N
Sbjct: 429 TDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKEN 488

Query: 502 ADIVYQLG-------PNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQS 554
           A I+Y L        P +S+  ++  TGVL A R FD E+       VTA D+G PPL S
Sbjct: 489 AQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSS 548

Query: 555 QAAVIVTVLDENDNSPKFTHNHFQFFVSENL--------PKYSTVGVITVTDADAGENKA 606
             ++ + VLD+NDN+P+  +       S  +        P Y    V+ V D D+G+N  
Sbjct: 549 NVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV-DRDSGQNAW 607

Query: 607 VTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTIN 664
           ++  +L  ++   F +  ++G +++  +         +  V   D GQPP S+T  +T+ 
Sbjct: 608 LSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVA 667

Query: 665 VMD 667
           V D
Sbjct: 668 VAD 670



 Score =  246 bits (627), Expect = 1e-64
 Identities = 189/636 (29%), Positives = 300/636 (47%), Gaps = 53/636 (8%)

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           +++ V+D+NDN P F+   ++V I EN   G       A D D+G N+   Y    Q++P
Sbjct: 123 IEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSY----QLSP 178

Query: 298 ATKRLFAL---NNTTGL----ITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT- 349
              + F+L   +   G+    + ++ SLDREE AIH + + ASDG       TV ++VT 
Sbjct: 179 --NKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTV 236

Query: 350 -DVNDNPPNIDL-RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREV 407
            D NDN P   L  Y +S       + E  PV T++  +T +D+D   NG+V     +  
Sbjct: 237 FDANDNAPVFTLPEYRVS-------VPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLP 289

Query: 408 PFHLKAVYDNQYL--LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDN 465
              L     N+Y   ++ S  LDYE T  +  +I A D G  +   TA V + +ED NDN
Sbjct: 290 DTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDGG--AYLATAKVLITVEDVNDN 347

Query: 466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGV-- 523
            P      +   V+E++  G  +  ++  D DS +N  +   +     F  L++      
Sbjct: 348 SPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPF-KLEKSIDSYY 406

Query: 524 -LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
            L   R  DRE+   +  TVTA D G+PPL ++A  ++ V D NDN P F+   +  ++ 
Sbjct: 407 RLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIP 466

Query: 583 ENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDR 635
           EN  + +++  +T  D D+ EN  +  S+  D    V       ++  +GV+ +  SFD 
Sbjct: 467 ENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDY 526

Query: 636 EQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP----SNTSFKLVPLSA 691
           EQ       V A+D G PP SS   +++ V+D NDN+P ++ P      +T  +L P SA
Sbjct: 527 EQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 586

Query: 692 IPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRL 751
            PG +V +V AVD D+G NA L Y ++  +  GLF +   TG +         D     L
Sbjct: 587 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSL 646

Query: 752 VVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNED 811
           VV + D G P    T+ L     +        + DL   + E+P +    D +       
Sbjct: 647 VVAVQDHGQPPLSATVTLTVAVADSI---PQVLADL--GSFESPANSETSDLTL------ 695

Query: 812 YLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAA 847
           YL + +A ++   +  V++ +   +R  H SR   A
Sbjct: 696 YLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQA 731


>gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precursor
           [Homo sapiens]
          Length = 850

 Score =  372 bits (955), Expect = e-102
 Identities = 231/663 (34%), Positives = 355/663 (53%), Gaps = 42/663 (6%)

Query: 23  AQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSST 82
           A+++ Y+I EEL +   +GNI KDL +     A    A    R+VS+ G   L  ++  +
Sbjct: 32  ARQISYSIPEELEKGSFVGNISKDLGL-----APRELAERGVRIVSR-GRTQLFSLNPRS 85

Query: 83  GEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMF 142
           G + T + RIDRE+LCA ++      C     +++   D  +L  I+I V D NDNAP F
Sbjct: 86  GSLIT-AGRIDREELCAQSA-----RCVVSFNILV--EDRVKLFGIEIEVTDINDNAPKF 137

Query: 143 PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWP 202
            +  +++ I EN     RFP+P A DPD G N +Q Y+L   +  F L +     G K+P
Sbjct: 138 QAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKH-FSLRVQSRANGVKYP 196

Query: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
           +L+++ +LDRE++  + + +   DGG P +S T ++ VTV D NDN PVF   +  V +P
Sbjct: 197 ELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVP 256

Query: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
           EN PVGT ++ + ATD D G+N E+ Y F  +  P T+ L F LN  TG I +  +LD E
Sbjct: 257 ENLPVGTQLLTVTATDRDEGANGEVTYSF--RKLPDTQLLKFQLNKYTGEIKISENLDYE 314

Query: 322 ETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNT 381
           ET  +++ + A DG +  A A V I V DVNDN P + +  + SP+      +E  P+ T
Sbjct: 315 ETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPV------TEDSPLGT 368

Query: 382 KIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVA 441
            +AL+ V D D++ NG+V C I   +PF L+   D+ Y L     LD E    ++  + A
Sbjct: 369 VVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTA 428

Query: 442 SDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKN 501
           +D G P L+  A   +++ D NDNPP F+Q      + ENN RG  + +++A D DS +N
Sbjct: 429 TDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKEN 488

Query: 502 ADIVYQLG-------PNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQS 554
           A I+Y L        P +S+  ++  TGVL A R FD E+       VTA D+G PPL S
Sbjct: 489 AQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSS 548

Query: 555 QAAVIVTVLDENDNSPKFTHNHFQFFVSENL--------PKYSTVGVITVTDADAGENKA 606
             ++ + VLD+NDN+P+  +       S  +        P Y    V+ V D D+G+N  
Sbjct: 549 NVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV-DRDSGQNAW 607

Query: 607 VTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTIN 664
           ++  +L  ++   F +  ++G +++  +         +  V   D GQPP S+T  +T+ 
Sbjct: 608 LSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVA 667

Query: 665 VMD 667
           V D
Sbjct: 668 VAD 670



 Score =  246 bits (627), Expect = 1e-64
 Identities = 189/636 (29%), Positives = 300/636 (47%), Gaps = 53/636 (8%)

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           +++ V+D+NDN P F+   ++V I EN   G       A D D+G N+   Y    Q++P
Sbjct: 123 IEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSY----QLSP 178

Query: 298 ATKRLFAL---NNTTGL----ITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT- 349
              + F+L   +   G+    + ++ SLDREE AIH + + ASDG       TV ++VT 
Sbjct: 179 --NKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTV 236

Query: 350 -DVNDNPPNIDL-RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREV 407
            D NDN P   L  Y +S       + E  PV T++  +T +D+D   NG+V     +  
Sbjct: 237 FDANDNAPVFTLPEYRVS-------VPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLP 289

Query: 408 PFHLKAVYDNQYL--LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDN 465
              L     N+Y   ++ S  LDYE T  +  +I A D G  +   TA V + +ED NDN
Sbjct: 290 DTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDGG--AYLATAKVLITVEDVNDN 347

Query: 466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGV-- 523
            P      +   V+E++  G  +  ++  D DS +N  +   +     F  L++      
Sbjct: 348 SPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPF-KLEKSIDSYY 406

Query: 524 -LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
            L   R  DRE+   +  TVTA D G+PPL ++A  ++ V D NDN P F+   +  ++ 
Sbjct: 407 RLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIP 466

Query: 583 ENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDR 635
           EN  + +++  +T  D D+ EN  +  S+  D    V       ++  +GV+ +  SFD 
Sbjct: 467 ENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDY 526

Query: 636 EQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP----SNTSFKLVPLSA 691
           EQ       V A+D G PP SS   +++ V+D NDN+P ++ P      +T  +L P SA
Sbjct: 527 EQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 586

Query: 692 IPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRL 751
            PG +V +V AVD D+G NA L Y ++  +  GLF +   TG +         D     L
Sbjct: 587 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSL 646

Query: 752 VVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNED 811
           VV + D G P    T+ L     +        + DL   + E+P +    D +       
Sbjct: 647 VVAVQDHGQPPLSATVTLTVAVADSI---PQVLADL--GSFESPANSETSDLTL------ 695

Query: 812 YLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAA 847
           YL + +A ++   +  V++ +   +R  H SR   A
Sbjct: 696 YLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQA 731


>gi|94538350 protocadherin 17 precursor [Homo sapiens]
          Length = 1159

 Score =  370 bits (950), Expect = e-102
 Identities = 252/679 (37%), Positives = 364/679 (53%), Gaps = 55/679 (8%)

Query: 24  QELIYTIREELPENVPIGNIPKDLNISH-----INAATGTSASLVYRLVSKAGDAP-LVK 77
           + L Y++ EE      IGNI +D  +            G S S  YR++  +  AP L+ 
Sbjct: 19  KNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENS--APHLLD 76

Query: 78  VSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTND 137
           V + +G ++T   RIDRE LC         +C   LEV    ND   +  IK+ ++D ND
Sbjct: 77  VDADSGLLYT-KQRIDRESLCR-----HNAKCQLSLEV--FANDK-EICMIKVEIQDIND 127

Query: 138 NAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL-NGQSVFGLDIVETP 196
           NAP F S  I + I EN    +RFP+ SA DPD G NG++ Y L  +   +FGLD+    
Sbjct: 128 NAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRG 187

Query: 197 EGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQ 256
           +G K+P+L++Q+ LDREQ++ + + +   DGG P +S+T  + V V D NDN PVF+   
Sbjct: 188 DGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPS 247

Query: 257 VEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQR 316
             V +PENAP+GT VI L+ATDAD G N E+ Y F + V    + LF+++  TGLI V+ 
Sbjct: 248 YLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKG 307

Query: 317 SLDREETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLS 374
           +LD EE  + ++ V A D   +  PA   VT+ + D NDN P+I     +S   G   LS
Sbjct: 308 NLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIG---FVSVRQGA--LS 362

Query: 375 EKDPVNTKIALITVSDKDTDVNGKVICFI---------------EREVPFHLKAVYDNQY 419
           E  P  T IAL+ V+D+D+  NG++ C +                  VPF L+  YDN Y
Sbjct: 363 EAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFY 422

Query: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVS 479
            + T   LD E   E++  IVA D G P LN T    +K+ DENDNPP F + +  L V 
Sbjct: 423 TVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVH 482

Query: 480 ENNRRGLYLTTISATDEDSGKNADIVYQLGPN-------ASFFDLDRKTGVLTASRVFDR 532
           ENN  G YL ++ A D D G+N  + Y + P+        ++  ++   G + A R F+ 
Sbjct: 483 ENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNF 542

Query: 533 EEQERFIFTVTARDNGTPP-LQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE-NLPKYST 590
           E+ + F F V A+D+G P  L+S A V VTVLD NDN+P       Q   +E  +P+ + 
Sbjct: 543 EQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAG 602

Query: 591 VGVITVT----DADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFD 644
           +G +  T    D+D GE+  +T  I++ ND+  F +DP SG I++   F  +        
Sbjct: 603 LGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELV 662

Query: 645 VKATDGGQPPRSSTAKVTI 663
           VK TD G+P  S+ AK+ I
Sbjct: 663 VKVTDHGKPTLSAVAKLII 681



 Score =  270 bits (689), Expect = 8e-72
 Identities = 288/1086 (26%), Positives = 431/1086 (39%), Gaps = 177/1086 (16%)

Query: 139  APMFPSPVINISIPEN----TLINS-------RFPIPSATDPDTGFNGVQHYELLNGQSV 187
            AP      +N S+PE     T+I +       +  +P A     G +    Y +L   + 
Sbjct: 13   APALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAP 72

Query: 188  FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVND 247
              LD V+   G     L  +Q +DRE    +  K ++            +++V + D+ND
Sbjct: 73   HLLD-VDADSG----LLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDIND 127

Query: 248  NRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNN 307
            N P F   Q+E+ I ENA  GT      A D D G N    Y+           LF L+ 
Sbjct: 128  NAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRD----DHGLFGLDV 183

Query: 308  TTG-------LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT--DVNDNPPNI 358
             +         + +Q++LDRE+   H + + A DG   P  ATV INV   D NDN P  
Sbjct: 184  KSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSP-- 241

Query: 359  DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD-- 416
                +    +  V L E  P+ T +  +  +D D   NG+V+      VP  ++ ++   
Sbjct: 242  ----VFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSID 297

Query: 417  -NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN-QPVI 474
                L+     LDYE        + A D G   +     V VKL D NDN P      V 
Sbjct: 298  PKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVR 357

Query: 475  ELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-------------GPNASF-FDLDRK 520
            + ++SE    G  +  +  TD DSGKN  +  ++             GP  S  F L+  
Sbjct: 358  QGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEEN 417

Query: 521  TG---VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHF 577
                  +   R  DRE Q+ +  T+ ARD G+PPL S  +  + +LDENDN P+FT   +
Sbjct: 418  YDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLY 477

Query: 578  QFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSN 630
               V EN      +G +   D D G+N  V+ SIL  +   V       ++P +G I + 
Sbjct: 478  VLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYAL 537

Query: 631  VSFDREQQSSYTFDVKATDGGQPPR-SSTAKVTINVMDVNDNSPVVISPP--SNTSFKLV 687
             SF+ EQ  ++ F V A D G P    S A V + V+DVNDN+PV++ P   ++T+   V
Sbjct: 538  RSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQV 597

Query: 688  PLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVG 747
            P +A  G +V+ V A+D D G +  L Y IV GN+  LF IDP +G I            
Sbjct: 598  PRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTP 657

Query: 748  LHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPY 807
            +  LVV ++D G P                    S +  LI R++   L   +   +   
Sbjct: 658  VVELVVKVTDHGKP------------------TLSAVAKLIIRSVSGSLPEGVPRVNGEQ 699

Query: 808  QNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNK 867
             + D    +I  ++   ++++   +T+ V+C+  ++ +    + + AE+  P     + K
Sbjct: 700  HHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENK-EIRTYNCRIAEYSHPQLGGGKGK 758

Query: 868  KKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTT 927
            KKK  K                           N  + + +E+EE++        A    
Sbjct: 759  KKKINK---------------------------NDIMLVQSEVEERN--------AMNVM 783

Query: 928  FKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFV-----GGCDTLSK 982
               +SP LA      SP   F  +   P+S  +  V+   P  N         GC T   
Sbjct: 784  NVVSSPSLA-----TSPM-YFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFT 837

Query: 983  RSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEE 1042
               T++    A+  S                    ++DN P  P    S   F       
Sbjct: 838  GQGTNASETPATRMSI------------------IQTDNFPAEPNYMGSRQQF------- 872

Query: 1043 SHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKR 1102
                 Q   TF  P+  + S  DSG GD +   S              D    +A   K 
Sbjct: 873  ----VQSSSTFKDPE--RASLRDSGHGDSDQADS----DQDTNKGSCCDMSVREALKMKT 922

Query: 1103 TEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMP--PGLGPYQHPKSPLST 1160
            T     S P    P       E    CT EC VLGHSD CWMP  P     ++     + 
Sbjct: 923  TST--KSQPLEQEP-------EECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNL 973

Query: 1161 FAPQKE 1166
            F P  E
Sbjct: 974  FVPTVE 979


>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
          Length = 1101

 Score =  370 bits (949), Expect = e-102
 Identities = 246/710 (34%), Positives = 374/710 (52%), Gaps = 35/710 (4%)

Query: 12  LIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAG 71
           L+A L   +A    L Y++ EE      I N+ KD        A     +  +R+VS + 
Sbjct: 11  LLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAR--EAGFALDPRQASAFRVVSNS- 67

Query: 72  DAP-LVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKI 130
            AP LV ++ S+G +  T  +IDR+ LC      +  +C   LEV+   +    +  IK+
Sbjct: 68  -APHLVDINPSSG-LLVTKQKIDRDLLCR-----QSPKCIISLEVM---SSSMEICVIKV 117

Query: 131 IVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
            +KD NDNAP FP+  I + I E     +R P+ SA DPD+G  GVQ YEL   + +FGL
Sbjct: 118 EIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNE-LFGL 176

Query: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRP 250
           +I    +G ++ +L+V+++LDRE +  Y  +I   DGG P +  T  L + V+D NDN P
Sbjct: 177 EIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNP 236

Query: 251 VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG 310
           VF E    V +PEN+P  T VI+L+A+D D G+N ++ Y F   V   T+ LF ++  +G
Sbjct: 237 VFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSG 296

Query: 311 LITVQRSLDREETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRYIISPIN 368
           L+TV  +LD EE  ++++ V A D   +S PA   VT++V D NDNPP I+L  + S + 
Sbjct: 297 LVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSEL- 355

Query: 369 GTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLD 428
             V +SE  P    IAL+ VSD+D+ +NG+V C +   VPF L+  Y++   +     LD
Sbjct: 356 --VEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLD 412

Query: 429 YEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
            E   +++  I A D G P L       V + DENDN P F++P  ++ V ENN  G YL
Sbjct: 413 REQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL 472

Query: 489 TTISATDEDSGKNADIVYQLGPNA-------SFFDLDRKTGVLTASRVFDREEQERFIFT 541
            ++SA D D G N  + YQ+ P+        ++  ++  +G + A R F+ E+ + F F 
Sbjct: 473 LSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFK 532

Query: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFT-----HNHFQFFVSENLPKYSTVGVITV 596
           V A+D G P LQS A V V +LD NDN+P  T     +   + ++  N      V V+  
Sbjct: 533 VLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKA 592

Query: 597 TDADAGENKAVTLSIL-NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
            D D GEN  VT  +   D   F +D  +G +++  +F    +SSY   V A D G+   
Sbjct: 593 EDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSL 652

Query: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDV 705
           S++A V I +    D    + S   +  F ++ L +I G +   +  V +
Sbjct: 653 SASALVLIYLSPALDAQESMGSVNLSLIF-IIALGSIAGILFVTMIFVAI 701



 Score =  242 bits (618), Expect = 1e-63
 Identities = 198/697 (28%), Positives = 313/697 (44%), Gaps = 68/697 (9%)

Query: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
           L+ +Q +DR+       K  +            +++V + D+NDN P F   Q+E+ I E
Sbjct: 81  LVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISE 140

Query: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPAT-KRLFALNNTT-------GLITVQ 315
            A  GT +    A D D GS       FG Q    T   LF L   T         + V+
Sbjct: 141 AASPGTRIPLDSAYDPDSGS-------FGVQTYELTPNELFGLEIKTRGDGSRFAELVVE 193

Query: 316 RSLDREETAIHKVTVLASDGSSTPARATV--TINVTDVNDNPPNIDLRYIISPINGTVYL 373
           +SLDRE  + +   + A DG   P   TV  +I VTD NDN P      + S     V +
Sbjct: 194 KSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNP------VFSESTYAVSV 247

Query: 374 SEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD---NQYLLETSSLLDYE 430
            E  P NT +  +  SD D   NG+V+      V    + ++    +  L+  +  LDYE
Sbjct: 248 PENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYE 307

Query: 431 GTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIE---LSVSENNRRGLY 487
               +   + A D G  S+     V V + D NDNPP+ N   +    + VSE+   G  
Sbjct: 308 EGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYV 367

Query: 488 LTTISATDEDSGKNADIVYQLGPNASFF--DLDRKTGVLTASRVFDREEQERFIFTVTAR 545
           +  +  +D DSG N  +  +L  N  F   + +  + +L   R+ DRE+ +++  T+ AR
Sbjct: 368 IALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRL-DREQHDQYNLTIQAR 426

Query: 546 DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
           D G P LQS  +  V + DENDN P F+  ++Q  V EN    + +  ++  D D G N 
Sbjct: 427 DGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNG 486

Query: 606 AVTLSIL----NDNDNFV---LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
           +V+  I+     D   F    ++P SG I +  SF+ EQ  ++ F V A DGG P   S 
Sbjct: 487 SVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSN 546

Query: 659 AKVTINVMDVNDNSPVVISPP--SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
           A V + ++DVNDN+PV+ +PP  + T+   +P ++  G +V  V A D D G N  + Y 
Sbjct: 547 ATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYD 606

Query: 717 IVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVND 776
           +  G+ +G F ID V G +        +    + L+V   D G   SL    LV +Y++ 
Sbjct: 607 MTEGD-RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHG-KTSLSASALVLIYLSP 664

Query: 777 TAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLV 836
                                    D+ +   + +   I I  +     ++ V  + V +
Sbjct: 665 AL-----------------------DAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAI 701

Query: 837 RCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKK 873
           +C+  ++ +    + + AE+ S   + K +KKKK  K
Sbjct: 702 KCKRDNK-EIRTYNCRIAEY-SYGHQKKSSKKKKISK 736



 Score =  160 bits (406), Expect = 5e-39
 Identities = 146/530 (27%), Positives = 224/530 (42%), Gaps = 34/530 (6%)

Query: 295 VAPATKRLFALNNTTGLITVQRSLDREETAIH--KVTVLASDGSSTPARATVTINVTDVN 352
           V+ +   L  +N ++GL+  ++ +DR+       K  +     SS+     + + + D+N
Sbjct: 64  VSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLN 123

Query: 353 DNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHL- 411
           DN P+     I       + +SE     T+I L +  D D+   G     +     F L 
Sbjct: 124 DNAPSFPAAQI------ELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLE 177

Query: 412 -KAVYDNQYLLE--TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPI 468
            K   D     E      LD E    +SF+I A D G P    T  + +K+ D NDN P+
Sbjct: 178 IKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPV 237

Query: 469 FNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-----GPNASFFDLDRKTGV 523
           F++    +SV EN+     +  ++A+D D G N  +VY             F +D  +G+
Sbjct: 238 FSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGL 297

Query: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKF---THNHFQFF 580
           +T +   D EE   +   V A+D G   + +   V V+VLD NDN P     + N     
Sbjct: 298 VTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVE 357

Query: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQ 638
           VSE+ P    + ++ V+D D+G N  V   +L  N  F L  Y     I  +   DREQ 
Sbjct: 358 VSESAPPGYVIALVRVSDRDSGLNGRVQCRLLG-NVPFRLQEYESFSTILVDGRLDREQH 416

Query: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698
             Y   ++A DGG P   S    T+ + D NDN P    P       +V  +  PG+ + 
Sbjct: 417 DQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQV---IVQENNTPGAYLL 473

Query: 699 EVFAVDVDTGMNAELKYTIVSGNNKGL-----FRIDPVTGNITLEEKPAPTDVGLHRLVV 753
            V A D D G+N  + Y IV    + +       I+P +G+I                 V
Sbjct: 474 SVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKV 533

Query: 754 NISDLGYP--KSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIG 801
              D G P  +S  T+ ++ L VND     +    LI  T E  + RN G
Sbjct: 534 LAKDGGLPSLQSNATVRVIILDVNDNTPVIT-APPLINGTAEVYIPRNSG 582



 Score = 38.1 bits (87), Expect = 0.052
 Identities = 16/29 (55%), Positives = 19/29 (65%), Gaps = 1/29 (3%)

Query: 1129 CTQECLVLGHSDNCWMPPGLGPYQHPKSP 1157
            C +EC +LGHSD CWMP    P +  KSP
Sbjct: 910  CREECRILGHSDRCWMPRNPMPIR-SKSP 937


>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
          Length = 1100

 Score =  370 bits (949), Expect = e-102
 Identities = 246/710 (34%), Positives = 374/710 (52%), Gaps = 35/710 (4%)

Query: 12  LIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAG 71
           L+A L   +A    L Y++ EE      I N+ KD        A     +  +R+VS + 
Sbjct: 11  LLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAR--EAGFALDPRQASAFRVVSNS- 67

Query: 72  DAP-LVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKI 130
            AP LV ++ S+G +  T  +IDR+ LC      +  +C   LEV+   +    +  IK+
Sbjct: 68  -APHLVDINPSSG-LLVTKQKIDRDLLCR-----QSPKCIISLEVM---SSSMEICVIKV 117

Query: 131 IVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
            +KD NDNAP FP+  I + I E     +R P+ SA DPD+G  GVQ YEL   + +FGL
Sbjct: 118 EIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNE-LFGL 176

Query: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRP 250
           +I    +G ++ +L+V+++LDRE +  Y  +I   DGG P +  T  L + V+D NDN P
Sbjct: 177 EIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNP 236

Query: 251 VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG 310
           VF E    V +PEN+P  T VI+L+A+D D G+N ++ Y F   V   T+ LF ++  +G
Sbjct: 237 VFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSG 296

Query: 311 LITVQRSLDREETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRYIISPIN 368
           L+TV  +LD EE  ++++ V A D   +S PA   VT++V D NDNPP I+L  + S + 
Sbjct: 297 LVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSEL- 355

Query: 369 GTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLD 428
             V +SE  P    IAL+ VSD+D+ +NG+V C +   VPF L+  Y++   +     LD
Sbjct: 356 --VEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLD 412

Query: 429 YEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
            E   +++  I A D G P L       V + DENDN P F++P  ++ V ENN  G YL
Sbjct: 413 REQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL 472

Query: 489 TTISATDEDSGKNADIVYQLGPNA-------SFFDLDRKTGVLTASRVFDREEQERFIFT 541
            ++SA D D G N  + YQ+ P+        ++  ++  +G + A R F+ E+ + F F 
Sbjct: 473 LSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFK 532

Query: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFT-----HNHFQFFVSENLPKYSTVGVITV 596
           V A+D G P LQS A V V +LD NDN+P  T     +   + ++  N      V V+  
Sbjct: 533 VLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKA 592

Query: 597 TDADAGENKAVTLSIL-NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
            D D GEN  VT  +   D   F +D  +G +++  +F    +SSY   V A D G+   
Sbjct: 593 EDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSL 652

Query: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDV 705
           S++A V I +    D    + S   +  F ++ L +I G +   +  V +
Sbjct: 653 SASALVLIYLSPALDAQESMGSVNLSLIF-IIALGSIAGILFVTMIFVAI 701



 Score =  242 bits (618), Expect = 1e-63
 Identities = 198/697 (28%), Positives = 313/697 (44%), Gaps = 68/697 (9%)

Query: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
           L+ +Q +DR+       K  +            +++V + D+NDN P F   Q+E+ I E
Sbjct: 81  LVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISE 140

Query: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPAT-KRLFALNNTT-------GLITVQ 315
            A  GT +    A D D GS       FG Q    T   LF L   T         + V+
Sbjct: 141 AASPGTRIPLDSAYDPDSGS-------FGVQTYELTPNELFGLEIKTRGDGSRFAELVVE 193

Query: 316 RSLDREETAIHKVTVLASDGSSTPARATV--TINVTDVNDNPPNIDLRYIISPINGTVYL 373
           +SLDRE  + +   + A DG   P   TV  +I VTD NDN P      + S     V +
Sbjct: 194 KSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNP------VFSESTYAVSV 247

Query: 374 SEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD---NQYLLETSSLLDYE 430
            E  P NT +  +  SD D   NG+V+      V    + ++    +  L+  +  LDYE
Sbjct: 248 PENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYE 307

Query: 431 GTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIE---LSVSENNRRGLY 487
               +   + A D G  S+     V V + D NDNPP+ N   +    + VSE+   G  
Sbjct: 308 EGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYV 367

Query: 488 LTTISATDEDSGKNADIVYQLGPNASFF--DLDRKTGVLTASRVFDREEQERFIFTVTAR 545
           +  +  +D DSG N  +  +L  N  F   + +  + +L   R+ DRE+ +++  T+ AR
Sbjct: 368 IALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRL-DREQHDQYNLTIQAR 426

Query: 546 DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605
           D G P LQS  +  V + DENDN P F+  ++Q  V EN    + +  ++  D D G N 
Sbjct: 427 DGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNG 486

Query: 606 AVTLSIL----NDNDNFV---LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
           +V+  I+     D   F    ++P SG I +  SF+ EQ  ++ F V A DGG P   S 
Sbjct: 487 SVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSN 546

Query: 659 AKVTINVMDVNDNSPVVISPP--SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
           A V + ++DVNDN+PV+ +PP  + T+   +P ++  G +V  V A D D G N  + Y 
Sbjct: 547 ATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYD 606

Query: 717 IVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVND 776
           +  G+ +G F ID V G +        +    + L+V   D G   SL    LV +Y++ 
Sbjct: 607 MTEGD-RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHG-KTSLSASALVLIYLSP 664

Query: 777 TAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLV 836
                                    D+ +   + +   I I  +     ++ V  + V +
Sbjct: 665 AL-----------------------DAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAI 701

Query: 837 RCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKK 873
           +C+  ++ +    + + AE+ S   + K +KKKK  K
Sbjct: 702 KCKRDNK-EIRTYNCRIAEY-SYGHQKKSSKKKKISK 736



 Score =  160 bits (406), Expect = 5e-39
 Identities = 146/530 (27%), Positives = 224/530 (42%), Gaps = 34/530 (6%)

Query: 295 VAPATKRLFALNNTTGLITVQRSLDREETAIH--KVTVLASDGSSTPARATVTINVTDVN 352
           V+ +   L  +N ++GL+  ++ +DR+       K  +     SS+     + + + D+N
Sbjct: 64  VSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLN 123

Query: 353 DNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHL- 411
           DN P+     I       + +SE     T+I L +  D D+   G     +     F L 
Sbjct: 124 DNAPSFPAAQI------ELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLE 177

Query: 412 -KAVYDNQYLLE--TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPI 468
            K   D     E      LD E    +SF+I A D G P    T  + +K+ D NDN P+
Sbjct: 178 IKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPV 237

Query: 469 FNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-----GPNASFFDLDRKTGV 523
           F++    +SV EN+     +  ++A+D D G N  +VY             F +D  +G+
Sbjct: 238 FSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGL 297

Query: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKF---THNHFQFF 580
           +T +   D EE   +   V A+D G   + +   V V+VLD NDN P     + N     
Sbjct: 298 VTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVE 357

Query: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQ 638
           VSE+ P    + ++ V+D D+G N  V   +L  N  F L  Y     I  +   DREQ 
Sbjct: 358 VSESAPPGYVIALVRVSDRDSGLNGRVQCRLLG-NVPFRLQEYESFSTILVDGRLDREQH 416

Query: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698
             Y   ++A DGG P   S    T+ + D NDN P    P       +V  +  PG+ + 
Sbjct: 417 DQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQV---IVQENNTPGAYLL 473

Query: 699 EVFAVDVDTGMNAELKYTIVSGNNKGL-----FRIDPVTGNITLEEKPAPTDVGLHRLVV 753
            V A D D G+N  + Y IV    + +       I+P +G+I                 V
Sbjct: 474 SVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKV 533

Query: 754 NISDLGYP--KSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIG 801
              D G P  +S  T+ ++ L VND     +    LI  T E  + RN G
Sbjct: 534 LAKDGGLPSLQSNATVRVIILDVNDNTPVIT-APPLINGTAEVYIPRNSG 582



 Score = 38.1 bits (87), Expect = 0.052
 Identities = 16/29 (55%), Positives = 19/29 (65%), Gaps = 1/29 (3%)

Query: 1129 CTQECLVLGHSDNCWMPPGLGPYQHPKSP 1157
            C +EC +LGHSD CWMP    P +  KSP
Sbjct: 909  CREECRILGHSDRCWMPRNPMPIR-SKSP 936


>gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  367 bits (943), Expect = e-101
 Identities = 235/683 (34%), Positives = 358/683 (52%), Gaps = 42/683 (6%)

Query: 2   DLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSAS 61
           D R F+LL+ L+       A A  ++Y++ EE  +   +G+I KDL +     A      
Sbjct: 9   DYRGFFLLSILLGTPW--EAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERG--- 63

Query: 62  LVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND 121
              R++S+ G   L  ++  +G +  T+ RIDRE++CA ++      C       IL  D
Sbjct: 64  --VRIISR-GRTQLFALNQRSGSL-VTAGRIDREEICAQSA-----RCLVNFN--ILMED 112

Query: 122 FFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL 181
              L  I + + D NDN P F +  IN+ I ENT    RFP+  A DPD G N +Q Y+L
Sbjct: 113 KMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQL 172

Query: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
              +  F L +    +  K+P+L++++ LDRE++  + + +   DGG P +SSTA +QVT
Sbjct: 173 SPNRH-FSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVT 231

Query: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
           V DVND+ PVF   Q +V +PEN PVGT ++ +HA D D G N E+ Y F  ++ P   +
Sbjct: 232 VVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF-RKITPKLPK 290

Query: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLR 361
           +F LN+ TG I+    LD EETA +++ V A DG  +  +A V I V DVNDN P + + 
Sbjct: 291 MFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMT 350

Query: 362 YIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL 421
            + S I       E  P+ T IAL  + D+D+  NG+V C I   +PF L+   DN Y L
Sbjct: 351 SLSSSI------PEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRL 404

Query: 422 ETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN 481
            T+  LD E    ++  + A+D G P L++   + +++ D NDNPP F      + ++EN
Sbjct: 405 VTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAEN 464

Query: 482 NRRGLYLTTISATDEDSGKNADIVYQL-------GPNASFFDLDRKTGVLTASRVFDREE 534
           N RG  +  ++A D DS  NA I Y L        P +S+  ++  TGVL A + FD E+
Sbjct: 465 NPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQ 524

Query: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL--------P 586
                  VTA D+G PPL S  ++ + VLD+NDN P+  +       S  +        P
Sbjct: 525 LRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEP 584

Query: 587 KYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFD 644
            Y    V+ V D D+G+N  ++  +L  ++   F +  Y+G +++  +         +  
Sbjct: 585 GYLVTKVVAV-DKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQSLV 643

Query: 645 VKATDGGQPPRSSTAKVTINVMD 667
           V   D GQPP S+T  +T+ V D
Sbjct: 644 VAVQDHGQPPLSATVTLTVAVAD 666



 Score =  253 bits (647), Expect = 6e-67
 Identities = 192/641 (29%), Positives = 301/641 (46%), Gaps = 53/641 (8%)

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           + V + D+NDN P F   ++ V I EN   G       A D D+G+N+   Y    Q++P
Sbjct: 119 IDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSY----QLSP 174

Query: 298 ATKRLFALNNTTG-------LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT- 349
              R F+L   +G        + ++R LDREE  +H + + ASDG   P  +T  I VT 
Sbjct: 175 --NRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTV 232

Query: 350 -DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP 408
            DVND+ P      + S     V + E  PV T++  +   D D  VNG+V     +  P
Sbjct: 233 VDVNDHTP------VFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITP 286

Query: 409 FHLKAVYDNQYLLETSSL--LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNP 466
              K  + N    E S+L  LDYE T  +  ++ A D G  SL + A V + + D NDN 
Sbjct: 287 KLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD-GPGSLTK-AKVLITVLDVNDNA 344

Query: 467 PIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFF---DLDRKTGV 523
           P      +  S+ E+   G  +      D DSGKN ++   +  N  F     +D    +
Sbjct: 345 PEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRL 404

Query: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
           +T   + DRE    +  T+ A D GTPPL  +  + + V D NDN P F H+ +  +++E
Sbjct: 405 VTTKNL-DRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463

Query: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDN------DNFV-LDPYSGVIKSNVSFDRE 636
           N P+ +++ ++T  D D+ +N  +T S+  D        ++V ++  +GV+ +  SFD E
Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYE 523

Query: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP----SNTSFKLVPLSAI 692
           Q       V A D G PP SS   +++ V+D NDN P ++ P      +T  +L P SA 
Sbjct: 524 QLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAE 583

Query: 693 PGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLV 752
           PG +V +V AVD D+G NA L Y ++  +  GLF +   TG +         D     LV
Sbjct: 584 PGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQSLV 643

Query: 753 VNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDY 812
           V + D G P    T+ L       T   A  I +++          ++  S  PY  +  
Sbjct: 644 VAVQDHGQPPLSATVTL-------TVAVADSIPEVLADL------GSLEPSDGPYNYDLT 690

Query: 813 LTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQG 853
           L +++A+   + V +  + V + +R R   + +  Q S+ G
Sbjct: 691 LYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASEGG 731


>gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precursor
           [Homo sapiens]
          Length = 817

 Score =  367 bits (943), Expect = e-101
 Identities = 235/683 (34%), Positives = 358/683 (52%), Gaps = 42/683 (6%)

Query: 2   DLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSAS 61
           D R F+LL+ L+       A A  ++Y++ EE  +   +G+I KDL +     A      
Sbjct: 9   DYRGFFLLSILLGTPW--EAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERG--- 63

Query: 62  LVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND 121
              R++S+ G   L  ++  +G +  T+ RIDRE++CA ++      C       IL  D
Sbjct: 64  --VRIISR-GRTQLFALNQRSGSL-VTAGRIDREEICAQSA-----RCLVNFN--ILMED 112

Query: 122 FFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL 181
              L  I + + D NDN P F +  IN+ I ENT    RFP+  A DPD G N +Q Y+L
Sbjct: 113 KMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQL 172

Query: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
              +  F L +    +  K+P+L++++ LDRE++  + + +   DGG P +SSTA +QVT
Sbjct: 173 SPNRH-FSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVT 231

Query: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
           V DVND+ PVF   Q +V +PEN PVGT ++ +HA D D G N E+ Y F  ++ P   +
Sbjct: 232 VVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF-RKITPKLPK 290

Query: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLR 361
           +F LN+ TG I+    LD EETA +++ V A DG  +  +A V I V DVNDN P + + 
Sbjct: 291 MFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMT 350

Query: 362 YIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL 421
            + S I       E  P+ T IAL  + D+D+  NG+V C I   +PF L+   DN Y L
Sbjct: 351 SLSSSI------PEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRL 404

Query: 422 ETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN 481
            T+  LD E    ++  + A+D G P L++   + +++ D NDNPP F      + ++EN
Sbjct: 405 VTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAEN 464

Query: 482 NRRGLYLTTISATDEDSGKNADIVYQL-------GPNASFFDLDRKTGVLTASRVFDREE 534
           N RG  +  ++A D DS  NA I Y L        P +S+  ++  TGVL A + FD E+
Sbjct: 465 NPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQ 524

Query: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL--------P 586
                  VTA D+G PPL S  ++ + VLD+NDN P+  +       S  +        P
Sbjct: 525 LRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEP 584

Query: 587 KYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFD 644
            Y    V+ V D D+G+N  ++  +L  ++   F +  Y+G +++  +         +  
Sbjct: 585 GYLVTKVVAV-DKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQSLV 643

Query: 645 VKATDGGQPPRSSTAKVTINVMD 667
           V   D GQPP S+T  +T+ V D
Sbjct: 644 VAVQDHGQPPLSATVTLTVAVAD 666



 Score =  253 bits (647), Expect = 6e-67
 Identities = 192/641 (29%), Positives = 301/641 (46%), Gaps = 53/641 (8%)

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           + V + D+NDN P F   ++ V I EN   G       A D D+G+N+   Y    Q++P
Sbjct: 119 IDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSY----QLSP 174

Query: 298 ATKRLFALNNTTG-------LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT- 349
              R F+L   +G        + ++R LDREE  +H + + ASDG   P  +T  I VT 
Sbjct: 175 --NRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTV 232

Query: 350 -DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP 408
            DVND+ P      + S     V + E  PV T++  +   D D  VNG+V     +  P
Sbjct: 233 VDVNDHTP------VFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITP 286

Query: 409 FHLKAVYDNQYLLETSSL--LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNP 466
              K  + N    E S+L  LDYE T  +  ++ A D G  SL + A V + + D NDN 
Sbjct: 287 KLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD-GPGSLTK-AKVLITVLDVNDNA 344

Query: 467 PIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFF---DLDRKTGV 523
           P      +  S+ E+   G  +      D DSGKN ++   +  N  F     +D    +
Sbjct: 345 PEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRL 404

Query: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
           +T   + DRE    +  T+ A D GTPPL  +  + + V D NDN P F H+ +  +++E
Sbjct: 405 VTTKNL-DRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAE 463

Query: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDN------DNFV-LDPYSGVIKSNVSFDRE 636
           N P+ +++ ++T  D D+ +N  +T S+  D        ++V ++  +GV+ +  SFD E
Sbjct: 464 NNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYE 523

Query: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP----SNTSFKLVPLSAI 692
           Q       V A D G PP SS   +++ V+D NDN P ++ P      +T  +L P SA 
Sbjct: 524 QLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAE 583

Query: 693 PGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLV 752
           PG +V +V AVD D+G NA L Y ++  +  GLF +   TG +         D     LV
Sbjct: 584 PGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQSLV 643

Query: 753 VNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDY 812
           V + D G P    T+ L       T   A  I +++          ++  S  PY  +  
Sbjct: 644 VAVQDHGQPPLSATVTL-------TVAVADSIPEVLADL------GSLEPSDGPYNYDLT 690

Query: 813 LTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQG 853
           L +++A+   + V +  + V + +R R   + +  Q S+ G
Sbjct: 691 LYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASEGG 731


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  362 bits (929), Expect = 1e-99
 Identities = 232/700 (33%), Positives = 367/700 (52%), Gaps = 61/700 (8%)

Query: 8   LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67
           ++  L A L +   +  +L YT++EE      +GNI +DL +      T  SA     + 
Sbjct: 2   IVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLD----ITKLSARGFQTVP 57

Query: 68  SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIK 127
           +     P + ++  TG ++  + +IDRE++C      +   C   LEV +   +   L +
Sbjct: 58  NSR--TPYLDLNLETGVLYV-NEKIDREQICK-----QSPSCVLHLEVFL--ENPLELFQ 107

Query: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
           ++I V D NDN P FP P + + I E+    +RFP+ SA DPD G N ++ YE+    S 
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-TPNSY 166

Query: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG------------------- 228
           F LD+    +G ++ +L++++ LDREQ+  +   +   DGG                   
Sbjct: 167 FSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPP 226

Query: 229 TPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIR 288
             Q++ TA+L + V D NDN P F +    V +PEN+P GT VIQL+ATD D G N E+ 
Sbjct: 227 QQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVV 286

Query: 289 YIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD--GSSTPARATVTI 346
           Y F + ++P  + LF L+  TG + V   LD EE+ +++V V A D   ++ PA   V +
Sbjct: 287 YSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLV 346

Query: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIERE 406
            V D NDN P I    +   +      SE     T +AL +V+D+D++ NG+V C +  +
Sbjct: 347 RVLDANDNAPEISFSTVKEAV------SEGAAPGTVVALFSVTDRDSEENGQVQCELLGD 400

Query: 407 VPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNP 466
           VPF LK+ + N Y + T + LD E    ++  +VA D G+P+L+ +  ++V++ D NDN 
Sbjct: 401 VPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNA 460

Query: 467 PIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL------GPNA-SFFDLDR 519
           P F+QPV ++ V+ENN  G Y+  +SATD D G NA + Y +      G +  ++  ++ 
Sbjct: 461 PRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINS 520

Query: 520 KTGVLTASRVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFT---HN 575
           + G L A R FD E+ + F F V ARD G+P  L   A V + ++D+NDN+P        
Sbjct: 521 ENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPG 580

Query: 576 HFQFFVSENLPKYSTVGV----ITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKS 629
                  E LP+ +  G     +   DAD GEN  +T SI+  N+   F +D  +G +++
Sbjct: 581 RNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRT 640

Query: 630 --NVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
              V   R+ Q  Y   ++  D GQPP SSTA + + ++D
Sbjct: 641 ARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  226 bits (577), Expect = 8e-59
 Identities = 190/661 (28%), Positives = 298/661 (45%), Gaps = 86/661 (13%)

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           +++ V D+NDN P F E  + V I E+A  GT      A D D+G+N+   Y    ++ P
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDY----EITP 163

Query: 298 ATKRLFALN-------NTTGLITVQRSLDREETAIHKVTVLASDGSS------------- 337
            +   F+L+       N    + +++ LDRE+ A+H+  + A DG               
Sbjct: 164 NS--YFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGG 221

Query: 338 --------TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVS 389
                       A +TI V D NDN P  D      P+  TV L E  P  T +  +  +
Sbjct: 222 AGLPPQQQRTGTALLTIRVLDSNDNVPAFD-----QPVY-TVSLPENSPPGTLVIQLNAT 275

Query: 390 DKDTDVNGKVICFIEREVPFHLKAVYD---NQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
           D D   NG+V+      +    + ++        LE S  LDYE +  +   + A D G 
Sbjct: 276 DPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGP 335

Query: 447 PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
            ++     V V++ D NDN P  +   ++ +VSE    G  +   S TD DS +N  +  
Sbjct: 336 NAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQC 395

Query: 507 QLGPNASFF--DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD 564
           +L  +  F      +    +      DRE  + +  TV ARD G P L +  ++ V V D
Sbjct: 396 ELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSD 455

Query: 565 ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFV----- 619
            NDN+P+F+   +  +V+EN    + +  ++ TD D G N  +  SIL      +     
Sbjct: 456 VNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTY 515

Query: 620 --LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR-SSTAKVTINVMDVNDNSPVVI 676
             ++  +G + +  SFD EQ   ++F V+A D G P   +  A V I ++D NDN+P ++
Sbjct: 516 VSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIV 575

Query: 677 SP----PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVT 732
           +P        + +++P SA PG ++  V AVD D G NA L Y+IV GN   LFR+D  T
Sbjct: 576 APLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRT 635

Query: 733 GNI-TLEEKPAPTDVGL-HRLVVNISDLGYPKSLHTLVLVFLYVN---------DTAGNA 781
           G + T    PA  D    + LV+ + D G P    T  LV   V+          + G  
Sbjct: 636 GELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGG 695

Query: 782 SYIYDLIRRT--METPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVL-VRC 838
           S  +    R+   ET LD               LT+++ I  G++  I ++ + VL VRC
Sbjct: 696 SGEHQRPSRSGGGETSLD---------------LTLILIIALGSVSFIFLLAMIVLAVRC 740

Query: 839 R 839
           +
Sbjct: 741 Q 741



 Score = 39.3 bits (90), Expect = 0.023
 Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)

Query: 1107 GNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMP 1145
            G+SD ++       G+ +    CT+EC  LGHSD CWMP
Sbjct: 919  GDSDHDATNRAQSAGM-DLFSNCTEECKALGHSDRCWMP 956



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 34/107 (31%), Positives = 45/107 (42%), Gaps = 13/107 (12%)

Query: 660 KVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVS 719
           +V I V+D+NDN P    P        +  SA PG+      A D D G N+   Y I  
Sbjct: 107 QVEIEVLDINDNPPSFPEPDLTVE---ISESATPGTRFPLESAFDPDVGTNSLRDYEITP 163

Query: 720 GNNKGLFRIDPVT---GNITLE---EKPAPTD-VGLHRLVVNISDLG 759
            +    F +D  T   GN   E   EKP   +   +HR V+   D G
Sbjct: 164 NS---YFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGG 207


>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
          Length = 896

 Score =  362 bits (929), Expect = 1e-99
 Identities = 232/700 (33%), Positives = 367/700 (52%), Gaps = 61/700 (8%)

Query: 8   LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67
           ++  L A L +   +  +L YT++EE      +GNI +DL +      T  SA     + 
Sbjct: 2   IVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLD----ITKLSARGFQTVP 57

Query: 68  SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIK 127
           +     P + ++  TG ++  + +IDRE++C      +   C   LEV +   +   L +
Sbjct: 58  NSR--TPYLDLNLETGVLYV-NEKIDREQICK-----QSPSCVLHLEVFL--ENPLELFQ 107

Query: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
           ++I V D NDN P FP P + + I E+    +RFP+ SA DPD G N ++ YE+    S 
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-TPNSY 166

Query: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG------------------- 228
           F LD+    +G ++ +L++++ LDREQ+  +   +   DGG                   
Sbjct: 167 FSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPP 226

Query: 229 TPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIR 288
             Q++ TA+L + V D NDN P F +    V +PEN+P GT VIQL+ATD D G N E+ 
Sbjct: 227 QQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVV 286

Query: 289 YIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD--GSSTPARATVTI 346
           Y F + ++P  + LF L+  TG + V   LD EE+ +++V V A D   ++ PA   V +
Sbjct: 287 YSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLV 346

Query: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIERE 406
            V D NDN P I    +   +      SE     T +AL +V+D+D++ NG+V C +  +
Sbjct: 347 RVLDANDNAPEISFSTVKEAV------SEGAAPGTVVALFSVTDRDSEENGQVQCELLGD 400

Query: 407 VPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNP 466
           VPF LK+ + N Y + T + LD E    ++  +VA D G+P+L+ +  ++V++ D NDN 
Sbjct: 401 VPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNA 460

Query: 467 PIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL------GPNA-SFFDLDR 519
           P F+QPV ++ V+ENN  G Y+  +SATD D G NA + Y +      G +  ++  ++ 
Sbjct: 461 PRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINS 520

Query: 520 KTGVLTASRVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFT---HN 575
           + G L A R FD E+ + F F V ARD G+P  L   A V + ++D+NDN+P        
Sbjct: 521 ENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPG 580

Query: 576 HFQFFVSENLPKYSTVGV----ITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKS 629
                  E LP+ +  G     +   DAD GEN  +T SI+  N+   F +D  +G +++
Sbjct: 581 RNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRT 640

Query: 630 --NVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
              V   R+ Q  Y   ++  D GQPP SSTA + + ++D
Sbjct: 641 ARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  226 bits (577), Expect = 8e-59
 Identities = 190/661 (28%), Positives = 298/661 (45%), Gaps = 86/661 (13%)

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           +++ V D+NDN P F E  + V I E+A  GT      A D D+G+N+   Y    ++ P
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDY----EITP 163

Query: 298 ATKRLFALN-------NTTGLITVQRSLDREETAIHKVTVLASDGSS------------- 337
            +   F+L+       N    + +++ LDRE+ A+H+  + A DG               
Sbjct: 164 NS--YFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGG 221

Query: 338 --------TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVS 389
                       A +TI V D NDN P  D      P+  TV L E  P  T +  +  +
Sbjct: 222 AGLPPQQQRTGTALLTIRVLDSNDNVPAFD-----QPVY-TVSLPENSPPGTLVIQLNAT 275

Query: 390 DKDTDVNGKVICFIEREVPFHLKAVYD---NQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
           D D   NG+V+      +    + ++        LE S  LDYE +  +   + A D G 
Sbjct: 276 DPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGP 335

Query: 447 PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
            ++     V V++ D NDN P  +   ++ +VSE    G  +   S TD DS +N  +  
Sbjct: 336 NAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQC 395

Query: 507 QLGPNASFF--DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD 564
           +L  +  F      +    +      DRE  + +  TV ARD G P L +  ++ V V D
Sbjct: 396 ELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSD 455

Query: 565 ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFV----- 619
            NDN+P+F+   +  +V+EN    + +  ++ TD D G N  +  SIL      +     
Sbjct: 456 VNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTY 515

Query: 620 --LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR-SSTAKVTINVMDVNDNSPVVI 676
             ++  +G + +  SFD EQ   ++F V+A D G P   +  A V I ++D NDN+P ++
Sbjct: 516 VSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIV 575

Query: 677 SP----PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVT 732
           +P        + +++P SA PG ++  V AVD D G NA L Y+IV GN   LFR+D  T
Sbjct: 576 APLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRT 635

Query: 733 GNI-TLEEKPAPTDVGL-HRLVVNISDLGYPKSLHTLVLVFLYVN---------DTAGNA 781
           G + T    PA  D    + LV+ + D G P    T  LV   V+          + G  
Sbjct: 636 GELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGG 695

Query: 782 SYIYDLIRRT--METPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVL-VRC 838
           S  +    R+   ET LD               LT+++ I  G++  I ++ + VL VRC
Sbjct: 696 SGEHQRPSRSGGGETSLD---------------LTLILIIALGSVSFIFLLAMIVLAVRC 740

Query: 839 R 839
           +
Sbjct: 741 Q 741



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 34/107 (31%), Positives = 45/107 (42%), Gaps = 13/107 (12%)

Query: 660 KVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVS 719
           +V I V+D+NDN P    P        +  SA PG+      A D D G N+   Y I  
Sbjct: 107 QVEIEVLDINDNPPSFPEPDLTVE---ISESATPGTRFPLESAFDPDVGTNSLRDYEITP 163

Query: 720 GNNKGLFRIDPVT---GNITLE---EKPAPTD-VGLHRLVVNISDLG 759
            +    F +D  T   GN   E   EKP   +   +HR V+   D G
Sbjct: 164 NS---YFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGG 207


>gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  362 bits (928), Expect = 2e-99
 Identities = 225/660 (34%), Positives = 352/660 (53%), Gaps = 40/660 (6%)

Query: 25  ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
           ++ Y++ EEL +   +G+I +DL +     A         R++ + G   L  ++  +G 
Sbjct: 30  QIRYSVPEELEKGSRVGDISRDLGLEPRELAERG-----VRIIPR-GRTQLFALNPRSGS 83

Query: 85  IFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144
           +  T+ RIDRE+LC GA      +C  +L + IL  D  ++  +++ V+D NDNAP F  
Sbjct: 84  L-VTAGRIDREELCMGAI-----KC--QLNLDILMEDKVKIYGVEVEVRDINDNAPYFRE 135

Query: 145 PVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQL 204
             + I I EN     RFP+P A DPD G N +Q YEL +  + F L +    +G K+P+L
Sbjct: 136 SELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL-SPNTHFSLIVQNGADGSKYPEL 194

Query: 205 IVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPEN 264
           ++++ LDRE+K  + + +   DGG P ++ TA ++V V D NDN P F + +    +PEN
Sbjct: 195 VLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPEN 254

Query: 265 APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
             +GT ++ ++ATD D G NAE+RY F   V     ++F L+  +G I+    LD EE+ 
Sbjct: 255 LALGTQLLVVNATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESG 313

Query: 325 IHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384
            +++ V A D +   ARA V I V DVNDN P + L  + S +       E  P  T IA
Sbjct: 314 FYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSV------PENSPRGTLIA 367

Query: 385 LITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
           L+ V+D+D++ NG+VICFI+  +PF L+  Y N Y L T  +LD E    ++  + A+D 
Sbjct: 368 LLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDR 427

Query: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
           G P L+    + + + D NDNPP+F Q      + ENN RG+ L +++A D D  +NA I
Sbjct: 428 GTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQI 487

Query: 505 VYQLGPN-------ASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAA 557
            Y L  N       +S+  ++  TGVL A   FD E+       V ARDNG PPL S  +
Sbjct: 488 TYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVS 547

Query: 558 VIVTVLDENDNSPKFTHNHFQFFVSENL--------PKYSTVGVITVTDADAGENKAVTL 609
           + + VLD+NDN+P+  +       S  +        P Y    V+ V D D+G+N  ++ 
Sbjct: 548 LSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV-DRDSGQNAWLSY 606

Query: 610 SILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
            +L  ++   F +  ++G +++  +         +  V   D GQPP S+T  +T+ V D
Sbjct: 607 RLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666



 Score =  244 bits (622), Expect = 5e-64
 Identities = 195/670 (29%), Positives = 310/670 (46%), Gaps = 52/670 (7%)

Query: 204 LIVQQNLDREQKDTYVMKIKVE-DGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
           L+    +DRE+     +K ++  D     K     ++V V D+NDN P F+E ++E+ I 
Sbjct: 84  LVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKIS 143

Query: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK-RLFALNNTTGL----ITVQRS 317
           ENA         HA D DIG N+   Y    +++P T   L   N   G     + ++R+
Sbjct: 144 ENAATEMRFPLPHAWDPDIGKNSLQSY----ELSPNTHFSLIVQNGADGSKYPELVLKRA 199

Query: 318 LDREETAIHKVTVLASDGSSTPAR---ATVTINVTDVNDNPPNIDLRYIISPINGTVYLS 374
           LDREE A H + + ASDG   P R   A + + V D NDN P        +       + 
Sbjct: 200 LDREEKAAHHLVLTASDGGD-PVRTGTARIRVMVLDANDNAP------AFAQPEYRASVP 252

Query: 375 EKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD---NQYLLETSSLLDYEG 431
           E   + T++ ++  +D D  VN +V  +  R V      V+    N   + T   LD+E 
Sbjct: 253 ENLALGTQLLVVNATDPDEGVNAEVR-YSFRYVDDKAAQVFKLDCNSGTISTIGELDHEE 311

Query: 432 TKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTI 491
           +  +  ++ A D+   S     L+ V   D NDN P      +  SV EN+ RG  +  +
Sbjct: 312 SGFYQMEVQAMDNAGYSARAKVLITVL--DVNDNAPEVVLTSLASSVPENSPRGTLIALL 369

Query: 492 SATDEDSGKNADIVYQLGPNASFFDLDRKTG---VLTASRVFDREEQERFIFTVTARDNG 548
           +  D+DS +N  ++  +  N  F  L++  G    L    V DRE+   +  TVTA D G
Sbjct: 370 NVNDQDSEENGQVICFIQGNLPF-KLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRG 428

Query: 549 TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVT 608
           TPPL ++  + + V D NDN P F    +  ++ EN P+  ++  +T  D D  EN  +T
Sbjct: 429 TPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQIT 488

Query: 609 LSILNDN------DNFV-LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKV 661
            S+  +        ++V ++  +GV+ +  SFD EQ       V A D G PP SS   +
Sbjct: 489 YSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSL 548

Query: 662 TINVMDVNDNSPVVISPP----SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717
           ++ V+D NDN+P ++ P      +T  +L P SA PG +V +V AVD D+G NA L Y +
Sbjct: 549 SLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRL 608

Query: 718 VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDT 777
           +  +  GLF +   TG +         D     LVV + D G P    T+ L     +  
Sbjct: 609 LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSI 668

Query: 778 AGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVR 837
                 + DL   ++E+P +    D +       YL + +A ++   +  V++ + + +R
Sbjct: 669 ---PQVLADL--GSLESPANSETSDLTL------YLVVAVAAVSCVFLAFVILLLALRLR 717

Query: 838 CRHASRFKAA 847
             H SR   A
Sbjct: 718 RWHKSRLLQA 727


>gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  362 bits (928), Expect = 2e-99
 Identities = 225/660 (34%), Positives = 352/660 (53%), Gaps = 40/660 (6%)

Query: 25  ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
           ++ Y++ EEL +   +G+I +DL +     A         R++ + G   L  ++  +G 
Sbjct: 30  QIRYSVPEELEKGSRVGDISRDLGLEPRELAERG-----VRIIPR-GRTQLFALNPRSGS 83

Query: 85  IFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144
           +  T+ RIDRE+LC GA      +C  +L + IL  D  ++  +++ V+D NDNAP F  
Sbjct: 84  L-VTAGRIDREELCMGAI-----KC--QLNLDILMEDKVKIYGVEVEVRDINDNAPYFRE 135

Query: 145 PVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQL 204
             + I I EN     RFP+P A DPD G N +Q YEL +  + F L +    +G K+P+L
Sbjct: 136 SELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL-SPNTHFSLIVQNGADGSKYPEL 194

Query: 205 IVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPEN 264
           ++++ LDRE+K  + + +   DGG P ++ TA ++V V D NDN P F + +    +PEN
Sbjct: 195 VLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPEN 254

Query: 265 APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
             +GT ++ ++ATD D G NAE+RY F   V     ++F L+  +G I+    LD EE+ 
Sbjct: 255 LALGTQLLVVNATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESG 313

Query: 325 IHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384
            +++ V A D +   ARA V I V DVNDN P + L  + S +       E  P  T IA
Sbjct: 314 FYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSV------PENSPRGTLIA 367

Query: 385 LITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
           L+ V+D+D++ NG+VICFI+  +PF L+  Y N Y L T  +LD E    ++  + A+D 
Sbjct: 368 LLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDR 427

Query: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
           G P L+    + + + D NDNPP+F Q      + ENN RG+ L +++A D D  +NA I
Sbjct: 428 GTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQI 487

Query: 505 VYQLGPN-------ASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAA 557
            Y L  N       +S+  ++  TGVL A   FD E+       V ARDNG PPL S  +
Sbjct: 488 TYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVS 547

Query: 558 VIVTVLDENDNSPKFTHNHFQFFVSENL--------PKYSTVGVITVTDADAGENKAVTL 609
           + + VLD+NDN+P+  +       S  +        P Y    V+ V D D+G+N  ++ 
Sbjct: 548 LSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV-DRDSGQNAWLSY 606

Query: 610 SILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
            +L  ++   F +  ++G +++  +         +  V   D GQPP S+T  +T+ V D
Sbjct: 607 RLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666



 Score =  244 bits (622), Expect = 5e-64
 Identities = 195/670 (29%), Positives = 310/670 (46%), Gaps = 52/670 (7%)

Query: 204 LIVQQNLDREQKDTYVMKIKVE-DGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
           L+    +DRE+     +K ++  D     K     ++V V D+NDN P F+E ++E+ I 
Sbjct: 84  LVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKIS 143

Query: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK-RLFALNNTTGL----ITVQRS 317
           ENA         HA D DIG N+   Y    +++P T   L   N   G     + ++R+
Sbjct: 144 ENAATEMRFPLPHAWDPDIGKNSLQSY----ELSPNTHFSLIVQNGADGSKYPELVLKRA 199

Query: 318 LDREETAIHKVTVLASDGSSTPAR---ATVTINVTDVNDNPPNIDLRYIISPINGTVYLS 374
           LDREE A H + + ASDG   P R   A + + V D NDN P        +       + 
Sbjct: 200 LDREEKAAHHLVLTASDGGD-PVRTGTARIRVMVLDANDNAP------AFAQPEYRASVP 252

Query: 375 EKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD---NQYLLETSSLLDYEG 431
           E   + T++ ++  +D D  VN +V  +  R V      V+    N   + T   LD+E 
Sbjct: 253 ENLALGTQLLVVNATDPDEGVNAEVR-YSFRYVDDKAAQVFKLDCNSGTISTIGELDHEE 311

Query: 432 TKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTI 491
           +  +  ++ A D+   S     L+ V   D NDN P      +  SV EN+ RG  +  +
Sbjct: 312 SGFYQMEVQAMDNAGYSARAKVLITVL--DVNDNAPEVVLTSLASSVPENSPRGTLIALL 369

Query: 492 SATDEDSGKNADIVYQLGPNASFFDLDRKTG---VLTASRVFDREEQERFIFTVTARDNG 548
           +  D+DS +N  ++  +  N  F  L++  G    L    V DRE+   +  TVTA D G
Sbjct: 370 NVNDQDSEENGQVICFIQGNLPF-KLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRG 428

Query: 549 TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVT 608
           TPPL ++  + + V D NDN P F    +  ++ EN P+  ++  +T  D D  EN  +T
Sbjct: 429 TPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQIT 488

Query: 609 LSILNDN------DNFV-LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKV 661
            S+  +        ++V ++  +GV+ +  SFD EQ       V A D G PP SS   +
Sbjct: 489 YSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSL 548

Query: 662 TINVMDVNDNSPVVISPP----SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717
           ++ V+D NDN+P ++ P      +T  +L P SA PG +V +V AVD D+G NA L Y +
Sbjct: 549 SLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRL 608

Query: 718 VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDT 777
           +  +  GLF +   TG +         D     LVV + D G P    T+ L     +  
Sbjct: 609 LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSI 668

Query: 778 AGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVR 837
                 + DL   ++E+P +    D +       YL + +A ++   +  V++ + + +R
Sbjct: 669 ---PQVLADL--GSLESPANSETSDLTL------YLVVAVAAVSCVFLAFVILLLALRLR 717

Query: 838 CRHASRFKAA 847
             H SR   A
Sbjct: 718 RWHKSRLLQA 727


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  354 bits (908), Expect = 3e-97
 Identities = 263/805 (32%), Positives = 414/805 (51%), Gaps = 67/805 (8%)

Query: 3   LRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASL 62
           LR F+LL+ L     +  A  ++ ++ + EE P    +G I              T    
Sbjct: 25  LRVFWLLSLLPGQAWVHGAEPRQ-VFQVLEEQPPGTLVGTIQ-------------TRPGF 70

Query: 63  VYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDF 122
            YRL        L  ++SSTG ++TTS  IDRE L +             + +V+L +  
Sbjct: 71  TYRLSESHA---LFAINSSTGALYTTST-IDRESLPSDV-----------INLVVLSSAP 115

Query: 123 FRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQH--YE 180
               +++++V+D NDNAP+FP P I ++  E++    +  + +ATD D G NGV H  Y 
Sbjct: 116 TYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYR 175

Query: 181 LLNGQSV--FGLDIVETPEGE-KWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAI 237
           ++ G     F LDI   P GE  +  L+ +  LDRE    Y + ++VED G P++     
Sbjct: 176 IIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQ 235

Query: 238 LQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAP 297
           + VTV D+NDN PVF     +  +PE+A VG+SV+Q+ A DAD G+NA+IRY    +  P
Sbjct: 236 VNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP 295

Query: 298 ATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGS--STPARATVTINVTDVNDNP 355
                F ++  TGLITV+  LD E    + +TV A D    S   RA   I + DVNDN 
Sbjct: 296 -----FQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDND 350

Query: 356 PNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTD-VNGKVICFI---EREVPFHL 411
           P +  RY     +    + E   V T +AL+TV+D D+   NG +   I     +  F +
Sbjct: 351 PVVKFRY-FPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEV 409

Query: 412 K-AVYDNQYLLETSSLLDYEGTKEFSFKIVASDS-GKP------SLNQTALVRVKLEDEN 463
           + +   N  L++ +S LD E    ++  +  SD+ G P      + +  A + + + D N
Sbjct: 410 QSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIN 469

Query: 464 DNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKT 521
           D+PP+F+Q V  +++SE    G Y++ ISATD DSG NA++ Y +  G    +F +   +
Sbjct: 470 DHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHS 529

Query: 522 GVLT--ASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTH-NHFQ 578
           G++T  +S   DRE   + +  ++ARD G  P  S A ++VT+LD ND  P F+    + 
Sbjct: 530 GLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYD 589

Query: 579 FFVSENLPKYSTVGVITVTDADAGENKAVTLSIL---NDNDNFVLDPYSGVIKSNVSFDR 635
             V EN P  + + ++  TD D G+N  V  S+     D  +F LDP SG + +  S DR
Sbjct: 590 VSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDR 649

Query: 636 EQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGS 695
           E+Q+ Y+  V ATD G PP+SS A++ ++++D+NDNSPV         F  +  +   GS
Sbjct: 650 EEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPV---QYFAHIKENEPGGS 706

Query: 696 VVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755
            +  V A D D G N  +KY+I +G ++  F+++  +G I+        +   ++L +  
Sbjct: 707 YITTVSATDPDLGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVA 765

Query: 756 SDLGYPKSLHTLVLVFLYVNDTAGN 780
           +D G  +S +   +V + V DT  N
Sbjct: 766 TDGGNLQSPNQ-AIVTITVLDTQDN 789



 Score =  306 bits (783), Expect = 1e-82
 Identities = 236/739 (31%), Positives = 352/739 (47%), Gaps = 51/739 (6%)

Query: 36   ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
            ENV +G      ++  ++A+T    S +  L++      +  ++  TG++ TT+N IDRE
Sbjct: 804  ENVALG-----YHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQL-TTANVIDRE 857

Query: 96   KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENT 155
            +           + F++L+VV           + I VKD NDN+P F   + ++++ EN 
Sbjct: 858  E-----------QSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENW 906

Query: 156  LINSRFPIPSATDPDTGFNGVQHYELL-NGQSVFGLDIVETPEGEKWPQLIVQQNLDREQ 214
                      A DPD G NG+  Y L  N +++F ++       EK   + +   LD   
Sbjct: 907  QAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAIN-------EKNGTISLLGPLD-VH 958

Query: 215  KDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQL 274
              +Y ++I   D G PQ SS+ IL V V DVNDN PVF +   EV + E+ PV +   ++
Sbjct: 959  AGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKV 1018

Query: 275  HATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
             A+D D G+N EI Y            +F      G + ++  LDRE    + + V+ASD
Sbjct: 1019 QASDKDSGANGEIAYTIAEGNTGDAFGIF----PDGQLYIKSELDRELQDRYVLMVVASD 1074

Query: 335  GSSTPARATVTINV--TDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKD 392
             +  P  ATV + V   DVNDN P      + +  N T Y  E+    + +  ++  DKD
Sbjct: 1075 RAVEPLSATVNVTVILEDVNDNRP------LFNSTNYTFYFEEEQRAGSFVGKVSAVDKD 1128

Query: 393  TDVNGKVICFIEREVP-FHLKAV---YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPS 448
               NG+V    E   P F L A+     N +  +  SL+   GT  FSF ++A+D G P 
Sbjct: 1129 FGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQ 1188

Query: 449  -LNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQ 507
             L   A V V ++D NDN P F +   + ++SE+      +  +SA+D D G N  I Y 
Sbjct: 1189 PLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYS 1248

Query: 508  L--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
            +  G     F +D  +G +T     D E    +   + A D+GT PL S   + + +LDE
Sbjct: 1249 IIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDE 1308

Query: 566  NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSI--LNDNDNFVLDPY 623
            NDN+P F  +     V EN+     V  +T TD+D+G+N  +  SI   N++  F + P 
Sbjct: 1309 NDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPN 1368

Query: 624  SGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS 683
            +G I      D E QS Y  ++ A D G+PPRSST  V I+V D NDN P   S P    
Sbjct: 1369 TGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPP---SFPPGDI 1425

Query: 684  FKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKG-LFRIDPVTGNITLEEKPA 742
            FK +  +   G+ V  V A D D  +N +L YTI+    +G  F ID V G I    +  
Sbjct: 1426 FKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEID 1485

Query: 743  PTDVGLHRLVVNISDLGYP 761
                 L  L V  +D   P
Sbjct: 1486 REFANLFELTVKANDQAVP 1504



 Score =  299 bits (765), Expect = 1e-80
 Identities = 214/671 (31%), Positives = 334/671 (49%), Gaps = 58/671 (8%)

Query: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS- 186
            + + V D NDN+P+F      +++ E+  +NSRF    A+D D+G NG   Y +  G + 
Sbjct: 982  LTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG 1041

Query: 187  -VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
              FG+     P+G    QL ++  LDRE +D YV+ +   D      S+T  + V + DV
Sbjct: 1042 DAFGI----FPDG----QLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDV 1093

Query: 246  NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
            NDNRP+F       +  E    G+ V ++ A D D G N E+RY F   V P     F L
Sbjct: 1094 NDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSF-EMVQPD----FEL 1148

Query: 306  NNTTGLITVQRSLDREE------TAIHKVTVLASD-GSSTPAR--ATVTINVTDVNDNPP 356
            +  +G IT     DRE       TA+   TV+A+D G   P +  ATV + + D+NDN P
Sbjct: 1149 HAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAP 1208

Query: 357  NIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD 416
                +++      T+  SE     T++  ++ SD D   NG +   I       +K   +
Sbjct: 1209 ----KFLKDFYQATI--SESAANLTQVLRVSASDVDEGNNGLIHYSI-------IKGNEE 1255

Query: 417  NQYLLETSS-------LLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
             Q+ ++++S        LDYE T  +S  I A DSG   LN T  + + + DENDN P F
Sbjct: 1256 RQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSF 1315

Query: 470  NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527
             +  + + V EN R G  +++++ATD DSG NAD+ Y +    N   F +   TG +  +
Sbjct: 1316 PKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLA 1375

Query: 528  RVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
            +  D E Q  +   +TA+D G PP  S  +V++ V D NDN P F        + EN+P 
Sbjct: 1376 KKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPI 1435

Query: 588  YSTVGVITVTDADAGENKAVTLSILND---NDNFVLDPYSGVIKSNVSFDREQQSSYTFD 644
             ++V  +T  D DA  N  ++ +I+      ++F +D   G I +N   DRE  + +   
Sbjct: 1436 GTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELT 1495

Query: 645  VKATDGGQP---PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVF 701
            VKA D   P    R +   VTI V D+NDN P+ IS  +  +      SA+ GSV+  + 
Sbjct: 1496 VKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAA----DPSAVIGSVLTTIM 1551

Query: 702  AVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
            A D D G N E++Y I++G+    F +D  +G++ +     P+ + ++ L+V+ +DLG  
Sbjct: 1552 AADPDEGANGEIEYEIINGDT-DTFIVDRYSGDLRVASALVPSQL-IYNLIVSATDLGPE 1609

Query: 762  KSLHTLVLVFL 772
            +   T  L  +
Sbjct: 1610 RRKSTTELTII 1620



 Score =  295 bits (755), Expect = 2e-79
 Identities = 222/717 (30%), Positives = 350/717 (48%), Gaps = 53/717 (7%)

Query: 35   PENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDR 94
            PEN P+ ++     ++ I  ++     + Y + S        ++   TG++ + S  +D 
Sbjct: 2577 PENQPVSSL-----VTTITGSSLRGEPMSYYIAS-GNLGNTFQIDQLTGQV-SISQPLDF 2629

Query: 95   EKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPEN 154
            EK+     + E  +  F          F    K+ I V D NDNAP+F        I EN
Sbjct: 2630 EKIQKYVVWIEARDGGFP--------PFSSYEKLDITVLDVNDNAPIFKEDPFISEILEN 2681

Query: 155  TLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQ 214
             L   +    SA D D+G NG   YE++NG       I          ++   + LDRE+
Sbjct: 2682 -LSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSI-----NHATGEIRSVRPLDREK 2735

Query: 215  KDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQL 274
               YV+ IK  D G+P +S++  + + + D NDN P F +     H+PEN+P+G +V ++
Sbjct: 2736 VSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRV 2794

Query: 275  HATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
              +D DIG NA  RY       P     F +N +TG I + R L+RE+T  +++ V A D
Sbjct: 2795 TTSDEDIGINAISRYSIMDASLP-----FTINPSTGDIVISRPLNREDTDRYRIRVSAHD 2849

Query: 335  GSSTPARATVTINVTDVNDNPPNIDLR--YIISPINGTVYLSEKDPVNTKIALITVSDKD 392
               T +   VTI VTD+NDN P       Y+  P        E   + +K+  +  +D D
Sbjct: 2850 SGWTVS-TDVTIFVTDINDNAPRFSRTSYYLDCP--------ELTEIGSKVTQVFATDPD 2900

Query: 393  TDVNGKVICFIEREVP-FHLKAVYD---NQYLLETSSLLDYEGTK--EFSFKIVASDSGK 446
               NG+V  FI+ +   F + A      N+ +L+  ++  +        SF + +SD GK
Sbjct: 2901 EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK 2960

Query: 447  PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDE-DSGKNADIV 505
            PSL     V + + D NDN P F +      V++N + G  L  ++A D+ D G N+++ 
Sbjct: 2961 PSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVE 3020

Query: 506  YQLGPNASF--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL 563
            Y +  +     F LD  TG ++ +     +  + F  TVTA+D G PPL SQA V +TV 
Sbjct: 3021 YFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVT 3080

Query: 564  DENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLD 621
            +EN ++P+F+ +H    + E+    S V  ++  D DA  N  +  SI + N+   F ++
Sbjct: 3081 EENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAIN 3140

Query: 622  PYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSN 681
              +G++    + D E    +   + A DGG   R+    VT+NV+DVNDNSPV +   S+
Sbjct: 3141 SSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFL---SD 3197

Query: 682  TSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLE 738
              F  V  +A  G+ V  + A D D+G NA + YT+ S ++  LF IDP TG IT +
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQS-SDSDLFVIDPNTGVITTQ 3253



 Score =  294 bits (753), Expect = 3e-79
 Identities = 239/766 (31%), Positives = 362/766 (47%), Gaps = 66/766 (8%)

Query: 34   LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRID 93
            + EN P G+      +S  +   GT+ ++ Y +   AGD    +V++ +G + +T   +D
Sbjct: 698  IKENEPGGSYIT--TVSATDPDLGTNGTVKYSI--SAGDRSRFQVNAQSG-VISTRMALD 752

Query: 94   REKLCAGASYAEENECFFELEVVIL-------PNDFFRLIKIKIIVKDTNDNAPMFPSPV 146
            RE+  A           ++L++V         PN       + I V DT DN P+F    
Sbjct: 753  REEKTA-----------YQLQIVATDGGNLQSPNQAI----VTITVLDTQDNPPVFSQVA 797

Query: 147  INISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIV 206
             +  + EN  +       SA+  D   N    Y +  G    G+  +    G    QL  
Sbjct: 798  YSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQK-GMFAINQVTG----QLTT 850

Query: 207  QQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAP 266
               +DRE++  Y +K+ V  GGT   +   ++ +TV D+NDN P F +    V++ EN  
Sbjct: 851  ANVIDREEQSFYQLKV-VASGGT--VTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQ 907

Query: 267  VGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIH 326
             G S+ Q  A D D G N  + Y     +    K LFA+N   G I++   LD      +
Sbjct: 908  AGHSIFQAKAVDPDEGVNGMVLY----SLKQNPKNLFAINEKNGTISLLGPLD-VHAGSY 962

Query: 327  KVTVLASDGSSTPARATV--TINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384
            ++ +LASD       ++V  T+ V DVNDN P      +   ++  V LSE +PVN++  
Sbjct: 963  QIEILASDMGVPQLSSSVILTVYVHDVNDNSP------VFDQLSYEVTLSESEPVNSRFF 1016

Query: 385  LITVSDKDTDVNGKVICFIEREVPFHLKAVY-DNQYLLETSSLLDYEGTKEFSFKIVASD 443
             +  SDKD+  NG++   I          ++ D Q  L   S LD E    +   +VASD
Sbjct: 1017 KVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQ--LYIKSELDRELQDRYVLMVVASD 1074

Query: 444  SGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNAD 503
                 L+ T  V V LED NDN P+FN         E  R G ++  +SA D+D G N +
Sbjct: 1075 RAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGE 1134

Query: 504  IVYQLGPNASFFDLDRKTGVLTASRVFDREEQER------FIFTVTARDNGTP-PLQSQA 556
            + Y        F+L   +G +T +  FDRE   R      F FTV A D G P PL+ QA
Sbjct: 1135 VRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQA 1194

Query: 557  AVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND 616
             V V + D NDN+PKF  + +Q  +SE+    + V  ++ +D D G N  +  SI+  N+
Sbjct: 1195 TVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNE 1254

Query: 617  --NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPV 674
               F +D  SG +      D E   +Y+  ++A D G  P +ST  + I+++D NDN+P 
Sbjct: 1255 ERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTP- 1313

Query: 675  VISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGN 734
              S P +T F  V  +   G +V+ V A D D+G NA+L Y+I   NN G F I P TG+
Sbjct: 1314 --SFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGS 1371

Query: 735  ITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
            I L +K       L++L +   D G P    T+ +V ++V D   N
Sbjct: 1372 IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVV-IHVRDFNDN 1416



 Score =  286 bits (732), Expect = 8e-77
 Identities = 232/760 (30%), Positives = 363/760 (47%), Gaps = 61/760 (8%)

Query: 34   LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRID 93
            L EN+P+G+     N++  +A  G ++ L Y + S  GD+ L + +     +      +D
Sbjct: 1953 LMENLPVGSTVLVFNVT--DADDGINSQLTYSIAS--GDS-LGQFTVDKNGVLKVLKALD 2007

Query: 94   REKLCAGASYAEENECFFELEVVI--LP----NDFFRLIKIKIIVKDTNDNAPMFPSPVI 147
            RE           ++ F+ L V +  LP    + F    ++ II+ D NDN P F SP +
Sbjct: 2008 RE-----------SQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL 2056

Query: 148  NISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQ 207
               IPENT I++      ATDPD+G N    Y LLN   +     + T +GE    + + 
Sbjct: 2057 TY-IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLN--PLGNKFSIGTIDGE----VRLT 2109

Query: 208  QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267
              LDRE+   Y + +   D G P  SS+  + V V D+NDN P+F +   +V I EN   
Sbjct: 2110 GELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLT 2169

Query: 268  GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327
            GT +IQ+ A D D G+N ++RY     V   T + F +++ TG ITV + LDRE+T  + 
Sbjct: 2170 GTDIIQVFAADGDEGTNGQVRY---GIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYH 2226

Query: 328  VTVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIAL 385
            +TV A+D  STP   T T+++   D+ND  P  +L    SP +  V       +   I  
Sbjct: 2227 LTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFEL----SPYSVNV-PENLGTLPRTILQ 2281

Query: 386  ITVSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
            +   D D   N K+   +     +  F L A  +    L  +  LD E  + F   I A+
Sbjct: 2282 VVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGE----LGVTQSLDRETKERFVLMITAT 2337

Query: 443  DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502
            DSG P+L  T  + V ++D NDN P F       ++ E+   G  +  ++A+D D+ KNA
Sbjct: 2338 DSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA 2397

Query: 503  DIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVT 561
             ++  +G N S F ++  TG +  S + DRE ++ +   V   D G+P PL S  +V+VT
Sbjct: 2398 -VIRIIGGN-SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVT 2455

Query: 562  VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDN-DNFVL 620
            V D NDN P+F H+ +   +       S V  +TVTDAD G N  +  S+   N + F +
Sbjct: 2456 VTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHI 2515

Query: 621  DPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPS 680
            DP  G I +  +      S  TF V   DGG  P++ +  VT+  ++  D   V     +
Sbjct: 2516 DPLRGAIMA--AGPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQT 2573

Query: 681  NTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEK 740
                +  P+S++       V  +   +     + Y I SGN    F+ID +TG +++ + 
Sbjct: 2574 FMFPENQPVSSL-------VTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQP 2626

Query: 741  PAPTDVGLHRLVVNISDLGYP--KSLHTLVLVFLYVNDTA 778
                 +  + + +   D G+P   S   L +  L VND A
Sbjct: 2627 LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNA 2666



 Score =  281 bits (718), Expect = 4e-75
 Identities = 221/757 (29%), Positives = 351/757 (46%), Gaps = 63/757 (8%)

Query: 40   IGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCA 99
            IG+  K + ++ ++A  G +A + Y ++S A D+   ++   +G++  T  R+DRE+   
Sbjct: 1753 IGDGSKIMQLTAMDADEGANALVTYTIISGADDS--FRIDPESGDLIAT-RRLDRERRSK 1809

Query: 100  GASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINS 159
             +     ++     ++           +I I V D ND+ P F  PV +  IPE+T+  S
Sbjct: 1810 YSLLVRADDGLQSSDM-----------RINITVSDVNDHTPKFSRPVYSFDIPEDTIPGS 1858

Query: 160  RFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYV 219
                  ATD D+G NG   Y ++N     G+  +    G       + + LD E +  Y+
Sbjct: 1859 LVAAILATDDDSGVNGEITY-IVNEDDEDGIFFLNPITG----VFNLTRLLDYEVQQYYI 1913

Query: 220  MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDA 279
            + ++ EDGG   + +T  +   + DVNDN P+F        + EN PVG++V+  + TDA
Sbjct: 1914 LTVRAEDGG--GQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDA 1971

Query: 280  DIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP 339
            D G N+++ Y     +A          +  G++ V ++LDRE  + + + V   D    P
Sbjct: 1972 DDGINSQLTY----SIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIP 2027

Query: 340  A-----RATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTD 394
            A      A V+I + DVNDNPP       +SP     Y+ E  P++T +     +D D+ 
Sbjct: 2028 ASRFTSTAQVSIILLDVNDNPPT-----FLSP--KLTYIPENTPIDTVVFKAQATDPDSG 2080

Query: 395  VNGKVICFIEREVPFHLKAVYDNQYLLET-------SSLLDYEGTKEFSFKIVASDSGKP 447
             N     +IE    + L     N++ + T       +  LD E    ++  +VA+D G+P
Sbjct: 2081 PNS----YIE----YTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQP 2132

Query: 448  SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQ 507
            SL+ +  V V + D NDN PIF Q + ++ ++EN   G  +  + A D D G N  + Y 
Sbjct: 2133 SLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYG 2192

Query: 508  L--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
            +  G     F +D  TG +T ++  DRE+   +  TV A D G+ P    + V + +LD 
Sbjct: 2193 IVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDI 2252

Query: 566  NDNSPKFTHNHFQFFVSENLPKY-STVGVITVTDADAGENKAVTLSILNDN-DNFVLDPY 623
            ND  P F  + +   V ENL     T+  +   D D G N  ++  +   N DN      
Sbjct: 2253 NDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSA 2312

Query: 624  SGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS 683
            SG +    S DRE +  +   + ATD G P  + T  + + V DVNDN P      S   
Sbjct: 2313 SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTF---ASKAY 2369

Query: 684  FKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAP 743
            F  +P  A  G+ V  V A D D   NA ++  I+ GN++  F I+P TG I        
Sbjct: 2370 FTTIPEDAPTGTDVLLVNASDADASKNAVIR--IIGGNSQ--FTINPSTGQIITSALLDR 2425

Query: 744  TDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
                 + LVV  SD G P+ L +   V + V D   N
Sbjct: 2426 ETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDN 2462



 Score =  275 bits (702), Expect = 3e-73
 Identities = 226/747 (30%), Positives = 345/747 (46%), Gaps = 61/747 (8%)

Query: 34   LPENVPIGNIPKDLNISHINAAT--GTSASLVYRLVSKAGDAPLV----KVSSSTGEIFT 87
            L E  PIG      N+  I AA+  G+ A + Y +VS   +   V     +   TG I  
Sbjct: 1638 LKEGEPIGT-----NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTG-IIQ 1691

Query: 88   TSNRIDREKLCAGASYAEENECFFELEVVILPNDFF----RLIKIKIIVKDTNDNAPMFP 143
            T+  +DRE          +  C + ++V  +         +  +++I ++D NDN P+FP
Sbjct: 1692 TAAILDRE----------QGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFP 1741

Query: 144  SPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPEGEKWP 202
            + ++++++ EN    S+    +A D D G N +  Y +++G    F +D    PE     
Sbjct: 1742 TDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRID----PES---G 1794

Query: 203  QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
             LI  + LDRE++  Y + ++ +DG    +SS   + +TVSDVND+ P F        IP
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTPKFSRPVYSFDIP 1851

Query: 263  ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREE 322
            E+   G+ V  + ATD D G N EI YI           +F LN  TG+  + R LD E 
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDG---IFFLNPITGVFNLTRLLDYEV 1908

Query: 323  TAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTK 382
               + +TV A DG        V  N+ DVNDNPP      I S  + +  L E  PV + 
Sbjct: 1909 QQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPP------IFSLNSYSTSLMENLPVGST 1962

Query: 383  IALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
            + +  V+D D  +N ++   I          V D   +L+    LD E    ++  +   
Sbjct: 1963 VLVFNVTDADDGINSQLTYSIASGDSLGQFTV-DKNGVLKVLKALDRESQSFYNLVVQVH 2021

Query: 443  DSGK---PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
            D  +        TA V + L D NDNPP F  P +   + EN      +    ATD DSG
Sbjct: 2022 DLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSG 2080

Query: 500  KNADIVYQ-LGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAV 558
             N+ I Y  L P  + F +    G +  +   DREE   +  TV A D G P L S   V
Sbjct: 2081 PNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEV 2140

Query: 559  IVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN- 617
            +V VLD NDN+P F    ++  ++EN    + +  +   D D G N  V   I+N N N 
Sbjct: 2141 VVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQ 2200

Query: 618  -FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI 676
             F +D  +G I      DRE+  +Y   V+ATD G  PR+ T+ V+I ++D+ND  PV  
Sbjct: 2201 EFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFE 2260

Query: 677  SPPSNTSFKLVP--LSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGN 734
              P + +   VP  L  +P +++ +V A D D G N++L Y +  GN    F +   +G 
Sbjct: 2261 LSPYSVN---VPENLGTLPRTIL-QVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-ASGE 2315

Query: 735  ITLEEKPAPTDVGLHRLVVNISDLGYP 761
            + + +           L++  +D G P
Sbjct: 2316 LGVTQSLDRETKERFVLMITATDSGSP 2342



 Score =  251 bits (641), Expect = 3e-66
 Identities = 202/673 (30%), Positives = 315/673 (46%), Gaps = 51/673 (7%)

Query: 128  IKIIVKDTNDNAPMFPSPVINISIPEN--TLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185
            + I++ D ND  P+F     ++++PEN  TL  +   +  A D D G N    Y L  G 
Sbjct: 2245 VSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVV-ARDDDRGSNSKLSYVLFGGN 2303

Query: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
                  +  + E      L V Q+LDRE K+ +V+ I   D G+P  + T  + V V DV
Sbjct: 2304 EDNAFTLSASGE------LGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDV 2357

Query: 246  NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
            NDN P F        IPE+AP GT V+ ++A+DAD   NA IR I G          F +
Sbjct: 2358 NDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGG-------NSQFTI 2410

Query: 306  NNTTGLITVQRSLDREETAIHKVTVLASD-GSSTP--ARATVTINVTDVNDNPPNIDLRY 362
            N +TG I     LDRE    + + V+ SD GS  P  +  +V + VTDVNDNPP      
Sbjct: 2411 NPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHP 2470

Query: 363  IISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI--EREVPFHLKAVYDNQYL 420
             ++      ++       + +  +TV+D D   N ++   +       FH+  +     +
Sbjct: 2471 YVT------HIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPL--RGAI 2522

Query: 421  LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480
            +    L    G  E +F +   D G      +  V V+  ++ D P +           E
Sbjct: 2523 MAAGPL---NGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKV-RAKEQTFMFPE 2578

Query: 481  NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
            N      +TTI+ +    G+        G   + F +D+ TG ++ S+  D E+ ++++ 
Sbjct: 2579 NQPVSSLVTTITGSSL-RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVV 2637

Query: 541  TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT--D 598
             + ARD G PP  S   + +TVLD NDN+P F  +    F+SE L   S   ++TV+  D
Sbjct: 2638 WIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDP---FISEILENLSPRKILTVSAMD 2694

Query: 599  ADAGENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRS 656
             D+G N  +   I+N N  ++F ++  +G I+S    DRE+ S Y   +K++D G P +S
Sbjct: 2695 KDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQS 2754

Query: 657  STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
            ++ KV IN++D NDN+P      S      VP ++  G  V  V   D D G+NA  +Y+
Sbjct: 2755 TSVKVMINILDENDNAPRF----SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYS 2810

Query: 717  IVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVND 776
            I+  +    F I+P TG+I +       D   +R+ V+  D G+  S    + V   +ND
Sbjct: 2811 IMDASLP--FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFV-TDIND 2867

Query: 777  TA---GNASYIYD 786
             A      SY  D
Sbjct: 2868 NAPRFSRTSYYLD 2880



 Score =  248 bits (634), Expect = 2e-65
 Identities = 230/765 (30%), Positives = 359/765 (46%), Gaps = 58/765 (7%)

Query: 30   IREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTS 89
            I + + EN+PIG     ++++  +     +  L Y ++ +        +    G I+T +
Sbjct: 1425 IFKSIVENIPIGT--SVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNA 1482

Query: 90   NRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINI 149
              IDRE         + N+     + V +    + L  + I+V D NDN PMF S     
Sbjct: 1483 E-IDREFANLFELTVKAND-----QAVPIETRRYALKNVTILVTDLNDNVPMFISQNALA 1536

Query: 150  SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGE-KWPQLIVQQ 208
            + P + +I S      A DPD G NG   YE++NG +     IV+   G+ +    +V  
Sbjct: 1537 ADP-SAVIGSVLTTIMAADPDEGANGEIEYEIINGDT--DTFIVDRYSGDLRVASALVPS 1593

Query: 209  NLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVG 268
             L       Y + +   D G  ++ ST  L + +  ++   PVF + +    + E  P+G
Sbjct: 1594 QL------IYNLIVSATDLGPERRKSTTELTIILQGLDG--PVFTQPKYITILKEGEPIG 1645

Query: 269  TSVIQLHATDADIGSNAEIR-YIFGAQVAPAT-KRLFALNNTTGLITVQRSLDREETA-I 325
            T+VI + A  +  GS A +  YI   +    T  RLF +   TG+I     LDRE+ A +
Sbjct: 1646 TNVISIEAA-SPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACL 1704

Query: 326  HKVTVLASDGSST---PARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTK 382
            + V V A + S+      RA V I + D+NDNPP      +       + + E     +K
Sbjct: 1705 YLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDML------DLTVEENIGDGSK 1758

Query: 383  IALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
            I  +T  D D   N  V   I        +   ++  L+ T   LD E   ++S  +V +
Sbjct: 1759 IMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRR-LDRERRSKYSL-LVRA 1816

Query: 443  DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502
            D G  S +    + + + D ND+ P F++PV    + E+   G  +  I ATD+DSG N 
Sbjct: 1817 DDGLQSSDMR--INITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNG 1874

Query: 503  DIVYQLGPN--ASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
            +I Y +  +     F L+  TGV   +R+ D E Q+ +I TV A D G     +   V  
Sbjct: 1875 EITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ--FTTIRVYF 1932

Query: 561  TVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND--NF 618
             +LD NDN P F+ N +   + ENLP  STV V  VTDAD G N  +T SI + +    F
Sbjct: 1933 NILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQF 1992

Query: 619  VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRS---STAKVTINVMDVNDNSPVV 675
             +D  +GV+K   + DRE QS Y   V+  D  Q P S   STA+V+I ++DVNDN P  
Sbjct: 1993 TVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 2051

Query: 676  ISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVS--GNNKGLFRIDPVTG 733
            +SP        +P +    +VV +  A D D+G N+ ++YT+++  GN    F I  + G
Sbjct: 2052 LSP----KLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK---FSIGTIDG 2104

Query: 734  NITLEEKPAPTDVGLHRLVVNISDLGYP--KSLHTLVLVFLYVND 776
             + L  +    +V  + L V  +D G P   S   +V++ L +ND
Sbjct: 2105 EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDIND 2149



 Score =  248 bits (633), Expect = 3e-65
 Identities = 223/773 (28%), Positives = 357/773 (46%), Gaps = 63/773 (8%)

Query: 34  LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRID 93
           +PE+  +G+    L ++  +A  GT+A + YRL  +       ++   TG + T    +D
Sbjct: 259 VPEDAVVGS--SVLQVAAADADEGTNADIRYRLQDEGTP---FQMDPETG-LITVREPLD 312

Query: 94  REKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPM-----FPSPVIN 148
            E   A   Y+   +   +  V  L      LI++     D NDN P+     FP+    
Sbjct: 313 FE---ARRQYSLTVQAM-DRGVPSLTGRAEALIQLL----DVNDNDPVVKFRYFPATSRY 364

Query: 149 ISIPENTLINSRFPIPSATDPDT-GFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLI-- 205
            S+ EN  + +   + + TD D+   NG    ++L G      ++    +  K P L   
Sbjct: 365 ASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEV----QSSKVPNLSLI 420

Query: 206 -VQQNLDREQKDTYVMKIKVEDG-GTPQ------KSSTAILQVTVSDVNDNRPVFKEGQV 257
            V   LDRE+  +Y + + V D  G P       +SS A L + V+D+ND+ PVF +   
Sbjct: 421 KVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVY 480

Query: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS 317
            V++ E AP G+ V  + ATD D G NA +RY     V+      F ++  +GL+T   S
Sbjct: 481 RVNLSEEAPPGSYVSGISATDGDSGLNANLRYSI---VSGNGLGWFHISEHSGLVTTGSS 537

Query: 318 --LDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNIDLRYIISPINGTVYL 373
             LDRE  +   + + A D    P  + A + + + DVND  P         P    V +
Sbjct: 538 GGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFS-----QPEGYDVSV 592

Query: 374 SEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP----FHLKAVYDNQYLLETSSLLDY 429
            E  P  T++ ++  +D D   NG V   ++        F L  V      L T S LD 
Sbjct: 593 VENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGR---LSTISSLDR 649

Query: 430 EGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLT 489
           E    +S  ++A+D G P  +  A + V L D NDN P+F        + EN   G Y+T
Sbjct: 650 EEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYIT 709

Query: 490 TISATDEDSGKNADIVYQLGP-NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNG 548
           T+SATD D G N  + Y +   + S F ++ ++GV++     DREE+  +   + A D G
Sbjct: 710 TVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769

Query: 549 TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVT 608
                +QA V +TVLD  DN P F+   + F V EN+     VG ++ +  D   N +  
Sbjct: 770 NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYL 829

Query: 609 LSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDV 668
           ++  +    F ++  +G + +    DRE+QS Y   V A+ G     +    V I V D+
Sbjct: 830 ITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG---TVTGDTMVNITVKDL 886

Query: 669 NDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
           NDNSP  +    + +   V  +   G  + +  AVD D G+N  + Y++   N K LF I
Sbjct: 887 NDNSPHFLQAIESVN---VVENWQAGHSIFQAKAVDPDEGVNGMVLYSL-KQNPKNLFAI 942

Query: 729 DPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNA 781
           +   G I+L   P     G +++ +  SD+G P+ L + V++ +YV+D   N+
Sbjct: 943 NEKNGTISL-LGPLDVHAGSYQIEILASDMGVPQ-LSSSVILTVYVHDVNDNS 993



 Score =  238 bits (607), Expect = 3e-62
 Identities = 178/580 (30%), Positives = 285/580 (49%), Gaps = 34/580 (5%)

Query: 210  LDREQKDT-YVMKI-KVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267
            LDREQ    Y++ +  +E      ++  A +++T+ D+NDN PVF    +++ + EN   
Sbjct: 1696 LDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGD 1755

Query: 268  GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327
            G+ ++QL A DAD G+NA + Y     +       F ++  +G +   R LDRE  + + 
Sbjct: 1756 GSKIMQLTAMDADEGANALVTY----TIISGADDSFRIDPESGDLIATRRLDRERRSKYS 1811

Query: 328  VTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALIT 387
            + V A DG  + +   + I V+DVND+ P         P+  +  + E     + +A I 
Sbjct: 1812 LLVRADDGLQS-SDMRINITVSDVNDHTPKFS-----RPVY-SFDIPEDTIPGSLVAAIL 1864

Query: 388  VSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
             +D D+ VNG++   +  +    +  +     +   + LLDYE  + +   + A D G  
Sbjct: 1865 ATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG-- 1922

Query: 448  SLNQTALVRV--KLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIV 505
               Q   +RV   + D NDNPPIF+      S+ EN   G  +   + TD D G N+ + 
Sbjct: 1923 --GQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLT 1980

Query: 506  YQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP---LQSQAAVIV 560
            Y +  G +   F +D K GVL   +  DRE Q  +   V   D    P     S A V +
Sbjct: 1981 YSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSI 2039

Query: 561  TVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN-FV 619
             +LD NDN P F       ++ EN P  + V     TD D+G N  +  ++LN   N F 
Sbjct: 2040 ILLDVNDNPPTFLSPKLT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFS 2098

Query: 620  LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPP 679
            +    G ++     DRE+ S+YT  V ATD GQP  SS+ +V + V+D+NDN+P+     
Sbjct: 2099 IGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIF---- 2154

Query: 680  SNTSFKL-VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLE 738
            +   +K+ +  + + G+ + +VFA D D G N +++Y IV+GN    FRID VTG IT+ 
Sbjct: 2155 AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVA 2214

Query: 739  EKPAPTDVGLHRLVVNISDLG-YPKS-LHTLVLVFLYVND 776
            +         + L V  +D G  P++   T+ +V L +ND
Sbjct: 2215 KPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDIND 2254



 Score =  206 bits (524), Expect = 1e-52
 Identities = 178/695 (25%), Positives = 317/695 (45%), Gaps = 51/695 (7%)

Query: 33   ELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
            + PE   IG+  K   +   +   G++  + Y + S++      +++++TGEIF  + +I
Sbjct: 2880 DCPELTEIGS--KVTQVFATDPDEGSNGQVFYFIKSQS---EYFRINATTGEIF--NKQI 2932

Query: 93   DREKLCAGASYAEENECFFELEVVILPND-----FFRLIKIKIIVKDTNDNAPMFPSPVI 147
             + +   G S    N   F    ++  +D           + I + D+NDNAP F     
Sbjct: 2933 LKYQNVTGFSNVNINRHSF----IVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKY 2988

Query: 148  NISIPENTLINSRF-PIPSATDPDTGFNGVQHYELLNGQSV--FGLDIVETPEGEKWPQL 204
               + +N  + ++   + +  D D G N    Y + N   +  F LD         W  +
Sbjct: 2989 FTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLD-----NDTGW--I 3041

Query: 205  IVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPEN 264
             V  +L  +    + + +  +D G P  SS A + +TV++ N + P F +  +   IPE+
Sbjct: 3042 SVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPES 3101

Query: 265  APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
              +G+ V  + A D D   N  I+Y   +      + +FA+N++TG++T+ ++LD E   
Sbjct: 3102 HSIGSIVRTVSARDRDAAMNGLIKYSISSG---NEEGIFAINSSTGILTLAKALDYELCQ 3158

Query: 325  IHKVTVLASDGS--STPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTK 382
             H++T+ A DG   +     +VT+NV DVNDN P     ++      TV   E  P  T 
Sbjct: 3159 KHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPV----FLSDDYFPTVL--ENAPSGTT 3212

Query: 383  IALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
            +  +  +D D+  N  VI +  +     L  +  N  ++ T   LD+E  + +   + A 
Sbjct: 3213 VIHLNATDADSGTNA-VIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAF 3271

Query: 443  DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502
            +         A V ++L+  N+  P F   +    +SE   +G  +  + A+D D G + 
Sbjct: 3272 NVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDG 3331

Query: 503  DIVYQLGPNA--SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQS--QAAV 558
            ++ Y +  N+    F +++KTG +  S + DRE++ER    V A++ G+       +  V
Sbjct: 3332 EVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTV 3391

Query: 559  IVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA---GENKAVTLSILNDN 615
             VTVLD ND  P FT N +   +SE +P  + V  ++  D+D+       +  +   N+N
Sbjct: 3392 NVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNEN 3450

Query: 616  DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVV 675
              F ++P +G I      DRE    Y   V A D G P  + +A + + + D+NDN P++
Sbjct: 3451 GAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML 3510

Query: 676  ISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMN 710
                   S   V  +  PG++V  + + D D   N
Sbjct: 3511 -----TVSEGEVMENKRPGTLVMTLQSTDPDLPPN 3540



 Score =  197 bits (502), Expect = 4e-50
 Identities = 196/673 (29%), Positives = 301/673 (44%), Gaps = 54/673 (8%)

Query: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
            + I V + N + P F    ++ +IPE+  I S     SA D D   NG+  Y + +G   
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEE 3134

Query: 188  FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVND 247
             G+  + +  G     L + + LD E    + M I   DGG   ++    + V V DVND
Sbjct: 3135 -GIFAINSSTGI----LTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVND 3189

Query: 248  NRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNN 307
            N PVF        + ENAP GT+VI L+ATDAD G+NA I Y     V  +   LF ++ 
Sbjct: 3190 NSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYT----VQSSDSDLFVIDP 3245

Query: 308  TTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPI 367
             TG+IT Q  LD E    + +TV A +       +  T+N+     N       Y+   +
Sbjct: 3246 NTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTN------EYVPRFV 3299

Query: 368  NGTVY--LSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLE 422
            +   Y  +SE  P  T +  +  SD+D   +G+V   I    R+  F +       Y+  
Sbjct: 3300 SKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYV-- 3357

Query: 423  TSSLLDYEGTKEFSFKIVASDSG--KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE 480
             S +LD E  +  S K++A + G  + +      V V + D ND PPIF   +  + +SE
Sbjct: 3358 -SGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISE 3415

Query: 481  NNRRGLYLTTISATDEDSGKN-ADIVYQLGPNAS--FFDLDRKTGVLTASRVFDREEQER 537
                G ++T +SA D DS  + +   Y +G       F ++ +TG +T +   DRE    
Sbjct: 3416 GVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPI 3475

Query: 538  FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597
            +  +V A D+GTP     A+++VT+ D NDN P  T +  +  V EN    + V  +  T
Sbjct: 3476 YNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGE--VMENKRPGTLVMTLQST 3533

Query: 598  DADAGENKA----VTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
            D D   N+       LS       F L   +GV+ +    DREQ + +   V   D G P
Sbjct: 3534 DPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVP 3592

Query: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPL---SAIPGSVVAEVFAVDVDTGMN 710
              SST  V I V+D NDN      P  + + ++      +  PG ++  V   D D    
Sbjct: 3593 QMSSTGTVHITVIDQNDN------PSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV--- 3643

Query: 711  AELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
             +  +  ++     LF I    G   L  +P  TD G   L V +S+ G   ++ + + V
Sbjct: 3644 LDSFHCSLTSGVTSLFSIP--GGTCDLNSQPRSTD-GTFDLTV-LSNDGVHSTVTSNIRV 3699

Query: 771  FL--YVNDTAGNA 781
            F   + N T  N+
Sbjct: 3700 FFAGFSNATVDNS 3712



 Score =  174 bits (442), Expect = 4e-43
 Identities = 160/546 (29%), Positives = 254/546 (46%), Gaps = 44/546 (8%)

Query: 34   LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRID 93
            +PE+  IG+I + ++    +AA      L+   +S   +  +  ++SSTG I T +  +D
Sbjct: 3098 IPESHSIGSIVRTVSARDRDAAMN---GLIKYSISSGNEEGIFAINSSTG-ILTLAKALD 3153

Query: 94   REKLCAGASYAEENECFFELEVVILPNDFFR---LIKIKIIVKDTNDNAPMFPSPVINIS 150
             E LC             E+ +  +   +        + + V D NDN+P+F S     +
Sbjct: 3154 YE-LCQK----------HEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPT 3202

Query: 151  IPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNL 210
            + EN    +     +ATD D+G N V  Y + +  S   L +++   G     +  Q  L
Sbjct: 3203 VLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS--DLFVIDPNTGV----ITTQGFL 3256

Query: 211  DREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS 270
            D E K +Y + +K  +    ++ S A + + +   N+  P F        I E AP GT 
Sbjct: 3257 DFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTI 3316

Query: 271  VIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
            V ++ A+D D+G++ E+ Y IFG     + K+ F +N  TG I V   LDRE+     + 
Sbjct: 3317 VGEVFASDRDLGTDGEVHYLIFGN----SRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372

Query: 330  VLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALIT 387
            VLA +  S        VT+NVT ++ N P I    I S     V +SE  P+ T +  ++
Sbjct: 3373 VLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYS-----VQISEGVPIGTHVTFVS 3427

Query: 388  VSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
              D D+  +  +   FI         ++      +  ++ LD E    ++  ++A DSG 
Sbjct: 3428 AFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT 3487

Query: 447  PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKN-ADIV 505
            PS   +A + V LED NDN P+    V E  V EN R G  + T+ +TD D   N     
Sbjct: 3488 PSATGSASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFT 3545

Query: 506  YQL---GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV 562
            Y L   GP  S+F L    GVL+ +R  DRE+   F  +V  +D+G P + S   V +TV
Sbjct: 3546 YYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITV 3604

Query: 563  LDENDN 568
            +D+NDN
Sbjct: 3605 IDQNDN 3610



 Score =  129 bits (324), Expect = 2e-29
 Identities = 129/475 (27%), Positives = 206/475 (43%), Gaps = 57/475 (12%)

Query: 42   NIPKDLNISHINAA---TGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREK-- 96
            N P    + H+NA    +GT+A + Y + S   D+ L  +  +TG + TT   +D E   
Sbjct: 3206 NAPSGTTVIHLNATDADSGTNAVIAYTVQSS--DSDLFVIDPNTG-VITTQGFLDFETKQ 3262

Query: 97   ----LCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPV----IN 148
                     +  +E  C F                + I +K TN+  P F S +    I+
Sbjct: 3263 SYHLTVKAFNVPDEERCSFAT--------------VNIQLKGTNEYVPRFVSKLYYFEIS 3308

Query: 149  ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208
             + P+ T++   F    A+D D G +G  HY +       G  I      +K  Q+ V  
Sbjct: 3309 EAAPKGTIVGEVF----ASDRDLGTDGEVHYLIFGNSRKKGFQI-----NKKTGQIYVSG 3359

Query: 209  NLDREQKDTYVMKIKVEDGGTPQKSST--AILQVTVSDVNDNRPVFKEGQVEVHIPENAP 266
             LDRE+++   +K+  ++ G+ + +      + VTV D ND  P+F      V I E  P
Sbjct: 3360 ILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVP 3418

Query: 267  VGTSVIQLHATDAD-IGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAI 325
            +GT V  + A D+D I S +   Y  G+         F++N  TG ITV   LDRE   I
Sbjct: 3419 IGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGA---FSINPQTGQITVTAELDRETLPI 3475

Query: 326  HKVTVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
            + ++VLA D  +  A  + ++ VT  D+NDN P      +++   G V +  K P  T +
Sbjct: 3476 YNLSVLAVDSGTPSATGSASLLVTLEDINDNGP------MLTVSEGEV-MENKRP-GTLV 3527

Query: 384  ALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
              +  +D D   N G    ++    P           +L T+  +D E   +F   +V  
Sbjct: 3528 MTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTK 3587

Query: 443  DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDED 497
            DSG P ++ T  V + + D+NDNP       I ++   N   G  L ++   D D
Sbjct: 3588 DSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD 3642



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 81/333 (24%), Positives = 134/333 (40%), Gaps = 54/333 (16%)

Query: 27   IYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRL---VSKAGDAPLVKVSSSTG 83
            IY++  ++ E VPIG      +++ ++A    S     R    +    +     ++  TG
Sbjct: 3408 IYSV--QISEGVPIGT-----HVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTG 3460

Query: 84   EIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN---DFFRLIKIKIIVKDTNDNAP 140
            +I  T+  +DRE L             + L V+ + +          + + ++D NDN P
Sbjct: 3461 QITVTAE-LDRETLP-----------IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP 3508

Query: 141  MFPSPVINISIPENTLINSRFPIPSATDPDTGFN-GVQHYELLN---GQSVFGLDIVETP 196
            M    V    + EN    +      +TDPD   N G   Y LL+     S F L      
Sbjct: 3509 MLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGV- 3565

Query: 197  EGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQ 256
                   L   + +DREQ   + + +  +D G PQ SST  + +TV D NDN    +  +
Sbjct: 3566 -------LSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVE 3618

Query: 257  VEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL-NNTTGLITVQ 315
            + V+   N   G  +  +   D D+  +      F   +      LF++   T  L +  
Sbjct: 3619 IFVNYYGNLFPGGILGSVKPQDPDVLDS------FHCSLTSGVTSLFSIPGGTCDLNSQP 3672

Query: 316  RSLDREETAIHKVTVLASDGSSTPARATVTINV 348
            RS D        +TVL++DG      +TVT N+
Sbjct: 3673 RSTD----GTFDLTVLSNDG----VHSTVTSNI 3697


>gi|14589880 protocadherin gamma subfamily A, 3 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  353 bits (907), Expect = 4e-97
 Identities = 226/681 (33%), Positives = 359/681 (52%), Gaps = 42/681 (6%)

Query: 4   RDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLV 63
           R   LL AL+  L    +   ++ Y++ EEL +   +GNI  DL +     A        
Sbjct: 11  RGLALLCALLGTLCETGS--GQIRYSVSEELDKGSFVGNIANDLGLEPRELAERG----- 63

Query: 64  YRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFF 123
            R+VS+ G   L  ++  +G +  T+ RIDRE+LCA         C  ++ +++   D  
Sbjct: 64  VRIVSR-GRTQLFSLNPQSGSL-VTAERIDREELCAQIPL-----CLVKINILV--EDKL 114

Query: 124 RLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN 183
           ++ +++I +KD NDNAP FP+  + I I E T+  +RFPI +A DPD G N +Q+Y+L +
Sbjct: 115 KIFEVEIEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKL-S 173

Query: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS 243
               F L +    EG K+P+L++++ LDRE+K+ + + +   DGG P  S    +QV V 
Sbjct: 174 PNDYFSLAVNSVSEGAKYPELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVL 233

Query: 244 DVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
           D NDN P+F + +  V + EN PVGT ++ ++ATD D G NA++ YI         + +F
Sbjct: 234 DANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAE-IF 292

Query: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
            LN+ +G +++ +SLD E+   +++ + A DG    +RA + + V DVNDN P I +  +
Sbjct: 293 HLNSVSGEVSILKSLDYEDAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSL 352

Query: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
            S +       E+  V  +IALI V D+D+  NG+V  F+   +PF L+   D  Y L T
Sbjct: 353 TSSV------PEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVT 406

Query: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
           ++ LD E   E++  + ASD G P L+    + + + D NDNPP F        + ENN 
Sbjct: 407 ATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNP 466

Query: 484 RGLYLTTISATDEDSGKNADIVYQL-------GPNASFFDLDRKTGVLTASRVFDREEQE 536
           RG  + +++A D DS  NA I Y L        P +SF  ++  TGVL A R FD E+  
Sbjct: 467 RGASIFSVTAQDPDSNNNARITYALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFR 526

Query: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL--------PKY 588
                VTA D+G PPL S  ++ + VLD+NDN+P+  +       S  +        P Y
Sbjct: 527 DLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGY 586

Query: 589 STVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVK 646
               V+ V D D+G+N  ++  +L  ++   F +  ++G +++  +         +  V 
Sbjct: 587 LVTKVVAV-DRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVA 645

Query: 647 ATDGGQPPRSSTAKVTINVMD 667
             D GQPP S+T  +T+ V D
Sbjct: 646 VQDHGQPPLSATVTLTVAVAD 666



 Score =  244 bits (622), Expect = 5e-64
 Identities = 195/683 (28%), Positives = 323/683 (47%), Gaps = 68/683 (9%)

Query: 204 LIVQQNLDREQKDTYV------MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQV 257
           L+  + +DRE+    +      + I VED     K     +++ + D+NDN P F   ++
Sbjct: 84  LVTAERIDREELCAQIPLCLVKINILVED-----KLKIFEVEIEIKDINDNAPNFPTEEL 138

Query: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG-----LI 312
           E+ I E    GT      A D D+G N+   Y    +++P      A+N+ +       +
Sbjct: 139 EIKIGELTVPGTRFPIKTAFDPDVGINSLQNY----KLSPNDYFSLAVNSVSEGAKYPEL 194

Query: 313 TVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGT 370
            ++R+LDRE+  IH++ ++ASDG        + I V   D NDNPP      + +     
Sbjct: 195 VLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPP------MFTQPEYR 248

Query: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP------FHLKAVYDNQYLLETS 424
           V + E  PV T++  +  +D D   N +V   +++ +P      FHL +V     +L++ 
Sbjct: 249 VSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDK-MPGKIAEIFHLNSVSGEVSILKS- 306

Query: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
             LDYE    +  KI A D   P L   A + V + D NDN P      +  SV E    
Sbjct: 307 --LDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTV 362

Query: 485 GLYLTTISATDEDSGKNADI-VYQLG--PNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
           G  +  I   D DSG+N  + V+ LG  P      +D+   ++TA+ + DRE+   +  +
Sbjct: 363 GREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVTATSL-DREQISEYNIS 421

Query: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
           + A D G+PPL ++  + + V+D NDN P F H  +  ++ EN P+ +++  +T  D D+
Sbjct: 422 LRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPDS 481

Query: 602 GENKAVTLSILNDN------DNFV-LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPP 654
             N  +T ++  D        +FV ++  +GV+ +  SFD EQ       V A+D G PP
Sbjct: 482 NNNARITYALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPP 541

Query: 655 RSSTAKVTINVMDVNDNSPVVISPP----SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMN 710
            SS   + + V+D NDN+P ++ P      +T  +L P SA PG +V +V AVD D+G N
Sbjct: 542 LSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601

Query: 711 AELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
           A L Y ++  +  GLF +   TG +         D     LVV + D G P    T+ L 
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL- 660

Query: 771 FLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVI 830
                 T   A  I D++          ++  S++P  ++  L +++A+ A + V +  +
Sbjct: 661 ------TVAVADRIPDILADL------GSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFV 708

Query: 831 FVTVLVRCRHASRFKAAQRSKQG 853
            V + +R R   + +  Q S  G
Sbjct: 709 IVLLALRLRRWHKSRLLQASGGG 731


>gi|14196465 protocadherin gamma subfamily A, 3 isoform 2 precursor
           [Homo sapiens]
          Length = 829

 Score =  353 bits (907), Expect = 4e-97
 Identities = 226/681 (33%), Positives = 359/681 (52%), Gaps = 42/681 (6%)

Query: 4   RDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLV 63
           R   LL AL+  L    +   ++ Y++ EEL +   +GNI  DL +     A        
Sbjct: 11  RGLALLCALLGTLCETGS--GQIRYSVSEELDKGSFVGNIANDLGLEPRELAERG----- 63

Query: 64  YRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFF 123
            R+VS+ G   L  ++  +G +  T+ RIDRE+LCA         C  ++ +++   D  
Sbjct: 64  VRIVSR-GRTQLFSLNPQSGSL-VTAERIDREELCAQIPL-----CLVKINILV--EDKL 114

Query: 124 RLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN 183
           ++ +++I +KD NDNAP FP+  + I I E T+  +RFPI +A DPD G N +Q+Y+L +
Sbjct: 115 KIFEVEIEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKL-S 173

Query: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS 243
               F L +    EG K+P+L++++ LDRE+K+ + + +   DGG P  S    +QV V 
Sbjct: 174 PNDYFSLAVNSVSEGAKYPELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVL 233

Query: 244 DVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
           D NDN P+F + +  V + EN PVGT ++ ++ATD D G NA++ YI         + +F
Sbjct: 234 DANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAE-IF 292

Query: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
            LN+ +G +++ +SLD E+   +++ + A DG    +RA + + V DVNDN P I +  +
Sbjct: 293 HLNSVSGEVSILKSLDYEDAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSL 352

Query: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
            S +       E+  V  +IALI V D+D+  NG+V  F+   +PF L+   D  Y L T
Sbjct: 353 TSSV------PEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVT 406

Query: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
           ++ LD E   E++  + ASD G P L+    + + + D NDNPP F        + ENN 
Sbjct: 407 ATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNP 466

Query: 484 RGLYLTTISATDEDSGKNADIVYQL-------GPNASFFDLDRKTGVLTASRVFDREEQE 536
           RG  + +++A D DS  NA I Y L        P +SF  ++  TGVL A R FD E+  
Sbjct: 467 RGASIFSVTAQDPDSNNNARITYALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFR 526

Query: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL--------PKY 588
                VTA D+G PPL S  ++ + VLD+NDN+P+  +       S  +        P Y
Sbjct: 527 DLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGY 586

Query: 589 STVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVK 646
               V+ V D D+G+N  ++  +L  ++   F +  ++G +++  +         +  V 
Sbjct: 587 LVTKVVAV-DRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVA 645

Query: 647 ATDGGQPPRSSTAKVTINVMD 667
             D GQPP S+T  +T+ V D
Sbjct: 646 VQDHGQPPLSATVTLTVAVAD 666



 Score =  244 bits (622), Expect = 5e-64
 Identities = 195/683 (28%), Positives = 323/683 (47%), Gaps = 68/683 (9%)

Query: 204 LIVQQNLDREQKDTYV------MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQV 257
           L+  + +DRE+    +      + I VED     K     +++ + D+NDN P F   ++
Sbjct: 84  LVTAERIDREELCAQIPLCLVKINILVED-----KLKIFEVEIEIKDINDNAPNFPTEEL 138

Query: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG-----LI 312
           E+ I E    GT      A D D+G N+   Y    +++P      A+N+ +       +
Sbjct: 139 EIKIGELTVPGTRFPIKTAFDPDVGINSLQNY----KLSPNDYFSLAVNSVSEGAKYPEL 194

Query: 313 TVQRSLDREETAIHKVTVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGT 370
            ++R+LDRE+  IH++ ++ASDG        + I V   D NDNPP      + +     
Sbjct: 195 VLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPP------MFTQPEYR 248

Query: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP------FHLKAVYDNQYLLETS 424
           V + E  PV T++  +  +D D   N +V   +++ +P      FHL +V     +L++ 
Sbjct: 249 VSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDK-MPGKIAEIFHLNSVSGEVSILKS- 306

Query: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
             LDYE    +  KI A D   P L   A + V + D NDN P      +  SV E    
Sbjct: 307 --LDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTV 362

Query: 485 GLYLTTISATDEDSGKNADI-VYQLG--PNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
           G  +  I   D DSG+N  + V+ LG  P      +D+   ++TA+ + DRE+   +  +
Sbjct: 363 GREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVTATSL-DREQISEYNIS 421

Query: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
           + A D G+PPL ++  + + V+D NDN P F H  +  ++ EN P+ +++  +T  D D+
Sbjct: 422 LRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPDS 481

Query: 602 GENKAVTLSILNDN------DNFV-LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPP 654
             N  +T ++  D        +FV ++  +GV+ +  SFD EQ       V A+D G PP
Sbjct: 482 NNNARITYALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPP 541

Query: 655 RSSTAKVTINVMDVNDNSPVVISPP----SNTSFKLVPLSAIPGSVVAEVFAVDVDTGMN 710
            SS   + + V+D NDN+P ++ P      +T  +L P SA PG +V +V AVD D+G N
Sbjct: 542 LSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601

Query: 711 AELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
           A L Y ++  +  GLF +   TG +         D     LVV + D G P    T+ L 
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL- 660

Query: 771 FLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVI 830
                 T   A  I D++          ++  S++P  ++  L +++A+ A + V +  +
Sbjct: 661 ------TVAVADRIPDILADL------GSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFV 708

Query: 831 FVTVLVRCRHASRFKAAQRSKQG 853
            V + +R R   + +  Q S  G
Sbjct: 709 IVLLALRLRRWHKSRLLQASGGG 731


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,602,643
Number of Sequences: 37866
Number of extensions: 2447187
Number of successful extensions: 15540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 6198
Number of HSP's gapped (non-prelim): 1114
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.