Search of human proteins with 4507005

Search of human proteins with 4507005

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
         (557 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507005 solute carrier family 22 member 5 [Homo sapiens]          1115   0.0  
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          860   0.0  
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        301   1e-81
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   276   3e-74
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           275   1e-73
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          273   3e-73
gi|166064021 solute carrier family 22 (organic anion transporter...   264   2e-70
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   263   4e-70
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   258   1e-68
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          256   4e-68
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          248   1e-65
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   244   2e-64
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       241   1e-63
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       240   3e-63
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   238   1e-62
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   238   1e-62
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          223   3e-58
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   200   2e-51
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       196   5e-50
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       194   1e-49
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   194   2e-49
gi|157426885 organic cation transporter like 4 [Homo sapiens]         182   9e-46
gi|42542386 solute carrier family 22 (organic anion/cation trans...   177   2e-44
gi|153791484 putative UST1-like organic anion transporter [Homo ...   177   3e-44
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          173   3e-43
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   150   3e-36
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   144   2e-34
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       129   5e-30
gi|24308167 SV2 related protein [Homo sapiens]                        128   2e-29
gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo sap...   126   5e-29

>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score = 1115 bits (2883), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60
           MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
Sbjct: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60

Query: 61  AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120
           AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
Sbjct: 61  AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120

Query: 121 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 180
           QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
Sbjct: 121 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 180

Query: 181 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA 240
           TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA
Sbjct: 181 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA 240

Query: 241 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA 300
           FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA
Sbjct: 241 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA 300

Query: 301 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 360
           AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG
Sbjct: 301 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 360

Query: 361 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV 420
           LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV
Sbjct: 361 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV 420

Query: 421 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 480
           PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF
Sbjct: 421 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 480

Query: 481 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR 540
           VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR
Sbjct: 481 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR 540

Query: 541 MLKDGQERPTILKSTAF 557
           MLKDGQERPTILKSTAF
Sbjct: 541 MLKDGQERPTILKSTAF 557


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  860 bits (2221), Expect = 0.0
 Identities = 425/557 (76%), Positives = 482/557 (86%), Gaps = 6/557 (1%)

Query: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60
           MRDYDEV AFLGEWGPFQRLIFFLLSASIIPNGF G+S VFL  TPEHRCRVPDAANLSS
Sbjct: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS 60

Query: 61  AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120
           AWRN++VPLRLRDGREVPHSC RYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
Sbjct: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120

Query: 121 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 180
           QDVYLST+VTEWNLVCED+WK PLT SLFFVGVLLGSF+SGQLSDRFGRKNVLF TM +Q
Sbjct: 121 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 180

Query: 181 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA 240
           TGFSFLQIFS ++EMF VLFV+VGMGQISNYV AF+LGTEILGKSVRIIFSTLGVC F+A
Sbjct: 181 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA 240

Query: 241 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA 300
            GYM+LPLFAYFIRDWRMLL+ALT+PGVLCV LWWFIPESPRWLISQ RF EAE II+KA
Sbjct: 241 VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA 300

Query: 301 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 360
           AK N I VP+ IFD   +++L+  KQQ   ILDL RT NI ++TIMS++LWM  SVGYF 
Sbjct: 301 AKMNNIAVPAVIFD--SVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFA 358

Query: 361 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV 420
           LSLD PNLHGD ++NCFLSA++E+PAY+ AWLLL+ LPRRY +A  LF GG VLLF+QLV
Sbjct: 359 LSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLV 418

Query: 421 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 480
           P D Y+L+  LVM+GKFG+T+AFSM+YV+TAELYPT+VRNM VGV+STASR+GSI++PYF
Sbjct: 419 PVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF 478

Query: 481 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR 540
           VYLGAY+R LPYI+MGSLT+L  ILTLF PES G  LP+T++QM +VK  +  K    TR
Sbjct: 479 VYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK---KTR 535

Query: 541 MLKDGQERPTILKSTAF 557
              + +E P +L  TAF
Sbjct: 536 DSMETEENPKVL-ITAF 551


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  301 bits (770), Expect = 1e-81
 Identities = 188/564 (33%), Positives = 298/564 (52%), Gaps = 47/564 (8%)

Query: 2   RDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP-------- 53
           R ++ +   +G +G FQR+++F+ +   I  G   L+SVF+  TP H CR P        
Sbjct: 4   RHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVF 63

Query: 54  ---------DAANLSSAWRNHTVPLRLRDGR--EVPHSCRRYRLATIANFSALGLEPGRD 102
                    D   L S+ +   V ++L++G   E+    R  R     N S+LG E    
Sbjct: 64  HNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKR----ENTSSLGYEY--- 116

Query: 103 VDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQ 162
              G  ++  C+DG+ + Q+ + ST VT+WNLVC+  W A L   LF  GVLLGS   G 
Sbjct: 117 --TGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGY 174

Query: 163 LSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEIL 222
            SDR GR+ VL+ T      F     F+ ++  F+     + M      V  FV   E +
Sbjct: 175 FSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFI 234

Query: 223 GKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDW---RMLLVALTMPGVLCVALWWFIPE 279
           G   R  ++++ +  F+A G +++ L  Y +R W   +M+L  +T+P +LC    W +PE
Sbjct: 235 GMKSRT-WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC---WVLPE 290

Query: 280 SPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDL--------SSKKQQSHNI 331
           +P WL+S+GR+EEA+ I+   AK N     ++    SEL  L        S  + Q HN+
Sbjct: 291 TPFWLLSEGRYEEAQKIVDIMAKWNR----ASSCKLSELLSLDLQGPVSNSPTEVQKHNL 346

Query: 332 LDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAW 391
             L   W+I   T+   ++W T S+G++  SL++ NL G+ ++N FL  +VE+PAY    
Sbjct: 347 SYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVC 406

Query: 392 LLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTA 451
           + +  + RR  +A +LF        + ++P   Y L  V  MVGKF + AAF ++Y+YTA
Sbjct: 407 IAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTA 466

Query: 452 ELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPE 511
           ELYPT+VR++ VG  S   RL SIL+P+ V L +   F+P + +G++ +L+ +LTL LPE
Sbjct: 467 ELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPE 526

Query: 512 SFGTPLPDTIDQMLRVKGMKHRKT 535
           + G  L  T ++  +++     K+
Sbjct: 527 TLGKRLATTWEEAAKLESENESKS 550


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  276 bits (707), Expect = 3e-74
 Identities = 195/537 (36%), Positives = 283/537 (52%), Gaps = 28/537 (5%)

Query: 1   MRDYDEVTAFLGEWGPFQR---LIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAAN 57
           M   D++   +GE G FQ+   LI  LLSA+  P     +  VFL  TP+H C+ P  A 
Sbjct: 1   MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAP---ICVGIVFLGFTPDHHCQSPGVAE 57

Query: 58  LSS--AWR-----NHTVPLRLRDGREVPHSCRRYRLATIANFSALG-LEPGRDV--DLGQ 107
           LS    W      N+TVP     G      CRRY +    N SAL  ++P   +  +   
Sbjct: 58  LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDW--NQSALSCVDPLASLATNRSH 115

Query: 108 LEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRF 167
           L    C DGW +  D   S+IVTE+NLVC D WK  L  S    G L GS   G  +DRF
Sbjct: 116 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173

Query: 168 GRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR 227
           GRK  L  T+ +      L  FS N+   ++  +L G+    N++A + L TE +G   R
Sbjct: 174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233

Query: 228 IIFSTLGVCIFYAF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 285
               T+ +    AF  G + L   AY +  WR L +A+++P  L +  +W +PESPRWL+
Sbjct: 234 ---RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLL 290

Query: 286 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI 345
           SQ R  EA  I+   A+ NG + P+ +   S  +D++ K   S    DL RT  +R  T 
Sbjct: 291 SQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPS--FADLFRTPRLRKRTF 348

Query: 346 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT 405
           + + LW T SV Y GL L      G+++++   SA+VE+P   +A + +  + R Y MA 
Sbjct: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408

Query: 406 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV 465
           +  L G+  L M  + PDL++L  +++ VG+ G+T A  M+ +  AELYPT VRN+GV V
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 468

Query: 466 SSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521
            S+   +G I++P+ V+ L    + LP IL   L +L A +TL LPE+ G  LP+T+
Sbjct: 469 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETM 525


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  275 bits (702), Expect = 1e-73
 Identities = 184/533 (34%), Positives = 281/533 (52%), Gaps = 24/533 (4%)

Query: 5   DEVTAFLGEWGPFQRLIFFLL---SASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-- 59
           D+V    GE+  FQ+ +FFLL   SA+  P  + G+  VFL  TP+HRCR P  A LS  
Sbjct: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPI-YVGI--VFLGFTPDHRCRSPGVAELSLR 62

Query: 60  SAWR-----NHTVPLRLRDGREVPHSCRRYRLA-TIANFSALGLEPGRDVDLGQLEQESC 113
             W      N+TVP     G   P  CRRY +    + F  +      D +  +L    C
Sbjct: 63  CGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPC 122

Query: 114 LDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVL 173
            DGW +      S+IVTE+NLVC + W   L  S   VG  +GS   G ++DRFGRK  L
Sbjct: 123 RDGWVYETPG--SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL 180

Query: 174 FVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTL 233
             T+ +      L   S  +   ++  ++ G+   + ++  ++L TE +G+  R    T+
Sbjct: 181 LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR---RTV 237

Query: 234 GVC--IFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFE 291
           G+   + Y  G +VL   AY +  WR L   + +P    +  +W IPESPRWLISQ +  
Sbjct: 238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNA 297

Query: 292 EAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLW 351
           EA  II+  AK NG  +P+++     L++ + KK    + LDL+RT  IR  T++ +  W
Sbjct: 298 EAMRIIKHIAKKNGKSLPASL-QRLRLEEETGKKLNP-SFLDLVRTPQIRKHTMILMYNW 355

Query: 352 MTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGG 411
            T SV Y GL +       +I+++ F SA+VE PA  +  L +  + RRY  A +  + G
Sbjct: 356 FTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAG 415

Query: 412 SVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASR 471
           +  L    +P DL +L  ++  +G+ G+T A+ +V +  AELYPT +RN+GV + S+   
Sbjct: 416 AACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCD 475

Query: 472 LGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 523
           +G I++P+ VY L      LP ++ G L ++   L L LPE+ G  LP+TI++
Sbjct: 476 IGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEE 528


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  273 bits (698), Expect = 3e-73
 Identities = 185/566 (32%), Positives = 303/566 (53%), Gaps = 46/566 (8%)

Query: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHR-CRVPDAANLS 59
           M  +DE    +GE+G FQR +F LL  + +   F  +  VFL   P+H  CR P AA L+
Sbjct: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60

Query: 60  S--AWR-----NHTVPLRLRDGREVPHS---CRRYRLATIANFSA-----------LGLE 98
               W      N T P     G E P     C+RY L   AN SA           L   
Sbjct: 61  ERCGWSPEEEWNRTAPASR--GPEPPERRGRCQRYLLEA-ANDSASATSALSCADPLAAF 117

Query: 99  PGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSF 158
           P R   L       C  GW ++Q    STIV+E++LVC + W   LT ++  +G L G+F
Sbjct: 118 PNRSAPL-----VPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAF 170

Query: 159 ISGQLSDRFGRKNVLFVTMGMQTGFSFLQI-FSKNFEMFVVLFVLVGMGQISNYVAAFVL 217
             G  +DR+GR  V+++   +  G + + + F+ NF +FV+   L G+     ++  +V+
Sbjct: 171 TLGYAADRYGRI-VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVI 229

Query: 218 GTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFI 277
            TEI+G   R I   + + +F+  G ++LP  AYFI +W+ + +A+T+P  L +  +W +
Sbjct: 230 VTEIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVV 288

Query: 278 PESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRT 337
           PESPRWLI++ + ++A  I+R+ AK NG  + S     SE+  ++ ++  + + LDL+RT
Sbjct: 289 PESPRWLITRKKGDKALQILRRIAKCNGKYLSSNY---SEIT-VTDEEVSNPSFLDLVRT 344

Query: 338 WNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYL 397
             +R  T++ +  W T +V Y GL +    + G+++++ F+S +VE+P  +L  L ++ L
Sbjct: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERL 404

Query: 398 PRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 457
            RR   A +  + G   L    +P  + +L T +  +G+ G+T AF +VY+  +ELYPT 
Sbjct: 405 GRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTT 464

Query: 458 VRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTP 516
           +RN GV + S     G I++P+ ++ L A    LP I+ G L  +   L + LPE+ G  
Sbjct: 465 LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIA 524

Query: 517 LPDTIDQMLRV------KGMKHRKTP 536
           LP+T+D + ++      K  +++KTP
Sbjct: 525 LPETVDDVEKLGSPHSCKCGRNKKTP 550


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  264 bits (674), Expect = 2e-70
 Identities = 175/534 (32%), Positives = 268/534 (50%), Gaps = 30/534 (5%)

Query: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60
           M  + +V A +G++G FQ  +  LL      + F   + VF++    H C V        
Sbjct: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAV-------- 52

Query: 61  AW-RNHTVPLRLR---------DGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQ 110
           AW +NHT  L            D    P  C  +R    AN S   +   R       E 
Sbjct: 53  AWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPP-ANASLQDILSHRFN-----ET 106

Query: 111 ESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 170
           + C  GWE+ ++  L ++  E+NLVC+       T S+F  G+L+G+ + G L DR GRK
Sbjct: 107 QPCDMGWEYPEN-RLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRK 165

Query: 171 NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230
             +   + + T       F  +FE+++ L   V         +   L TE +G S R   
Sbjct: 166 ATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQA 225

Query: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290
             L  C F + G MVL   AY  R+WR+L +  T PG+L    +W +PES RWL+++GR 
Sbjct: 226 VVLAQCNF-SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRM 284

Query: 291 EEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIML 350
           +EA  +I+KAA  N   +   + +    Q +  K   S N LDL R   +R VT++   +
Sbjct: 285 DEAIQLIQKAASVNRRKLSPELMN----QLVPEKTGPSGNALDLFRHPQLRKVTLIIFCV 340

Query: 351 WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLG 410
           W   S+GY+GLSL   +   D+++   +   VEVPA   +  ++Q   R++S    L LG
Sbjct: 341 WFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLG 400

Query: 411 GSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470
           G + + +  +P DL  + T+L +VGK    AAF++ YVY+AEL+PT++R  G+G+    S
Sbjct: 401 GLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFS 460

Query: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524
           R+G IL+P  + LG Y   LP ++ GSL I+  +L   LPE+ G  L DT+  +
Sbjct: 461 RIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDL 514


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  263 bits (671), Expect = 4e-70
 Identities = 177/536 (33%), Positives = 267/536 (49%), Gaps = 24/536 (4%)

Query: 4   YDEVTAFLGEWGPFQ--RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDA-ANLS- 59
           ++E+   +G +GPFQ   +    L   ++P  F  L  +FL A P HRC +P A AN S 
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHF--LLPIFLAAVPAHRCALPGAPANFSH 60

Query: 60  -SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES----CL 114
              W    +P   R+      SC R+        + LG E       G+LE E     C 
Sbjct: 61  QDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCS 114

Query: 115 DGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLF 174
            GWE+    + STI TEW+LVCE         + FF GVL+G+   G LSDRFGR+ +L 
Sbjct: 115 QGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLL 174

Query: 175 VTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLG 234
           V              S ++ MF +   L G       +    L  E L    R +   L 
Sbjct: 175 VAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLS 234

Query: 235 VCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAE 294
              F+  G M+L L  Y IRDWR LL+A+T+P    +   W++PES RWL++QG  +EA 
Sbjct: 235 -STFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAH 293

Query: 295 VIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ--QSHNILDLLRTWNIRMVTIMSIMLWM 352
             +   A+ NG  V    F    +  +++ ++  +  + LDL RT  +R +++  +++W 
Sbjct: 294 RYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWF 353

Query: 353 TISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGS 412
            ++  Y+GLSLD   L  +++    L   VE+P+ +L +L ++Y  RR + A  L   G+
Sbjct: 354 GVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL--GT 411

Query: 413 VLLF--MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470
            L F    LV  D+   +TVL ++GK    AAF+  Y++T+ELYPTV+R  G+G+++   
Sbjct: 412 ALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVG 471

Query: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLR 526
           RLG  L+P    L      LP +  G + +L A   L LPE+    LP+TI  + R
Sbjct: 472 RLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  258 bits (658), Expect = 1e-68
 Identities = 177/538 (32%), Positives = 267/538 (49%), Gaps = 26/538 (4%)

Query: 4   YDEVTAFLGEWGPFQ--RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDA-ANLS- 59
           ++E+   +G +GPFQ   +    L   ++P  F  L  +FL A P HRC +P A AN S 
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHF--LLPIFLAAVPAHRCALPGAPANFSH 60

Query: 60  -SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES----CL 114
              W    +P   R+      SC R+        + LG E       G+LE E     C 
Sbjct: 61  QDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCS 114

Query: 115 DGWEFSQDVYLSTIVTE--WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNV 172
            GWE+    + STI TE  W+LVCE         + FF GVL+G+   G LSDRFGR+ +
Sbjct: 115 QGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRL 174

Query: 173 LFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST 232
           L V              S ++ MF +   L G       +    L  E L    R +   
Sbjct: 175 LLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGV 234

Query: 233 LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEE 292
           L    F+  G M+L L  Y IRDWR LL+A+T+P    +   W++PES RWL++QG  +E
Sbjct: 235 LS-STFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKE 293

Query: 293 AEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ--QSHNILDLLRTWNIRMVTIMSIML 350
           A   +   A+ NG  V    F    +  +++ ++  +  + LDL RT  +R +++  +++
Sbjct: 294 AHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVV 353

Query: 351 WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLG 410
           W  ++  Y+GLSLD   L  +++    L   VE+P+ +L +L ++Y  RR + A  L   
Sbjct: 354 WFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL-- 411

Query: 411 GSVLLF--MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSST 468
           G+ L F    LV  D+   +TVL ++GK    AAF+  Y++T+ELYPTV+R  G+G+++ 
Sbjct: 412 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 471

Query: 469 ASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLR 526
             RLG  L+P    L      LP +  G + +L A   L LPE+    LP+TI  + R
Sbjct: 472 VGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 529


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  256 bits (654), Expect = 4e-68
 Identities = 170/530 (32%), Positives = 264/530 (49%), Gaps = 34/530 (6%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63
           + E+   +G  G FQ L   +L   I+      L  +F  ATP H CR P  A+ +  W 
Sbjct: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAS-TGPWV 61

Query: 64  NHTVPLRLRDGREVPHSCRRY---RLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120
               P    +G+  P  C R+     A++ N +   +EP             CLDGW ++
Sbjct: 62  LPMGP----NGK--PERCLRFVHPPNASLPNDTQRAMEP-------------CLDGWVYN 102

Query: 121 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 180
                 +IVTEW+LVC  +    +  S+F  G+L+G  + G LSDRFGR+ +L  +  + 
Sbjct: 103 STK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160

Query: 181 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST-LGVCIFY 239
                   FS  F +++V   L G G     ++  +L  E +   +R I ST LG C  Y
Sbjct: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC--Y 218

Query: 240 AFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 299
            FG  +LP  AY I  WR L + +++P  +     W+ PES RWL+  G+  +A  I+R+
Sbjct: 219 TFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278

Query: 300 AAKANGIVVPSTIFDPSELQDLSSKKQQS-----HNILDLLRTWNIRMVTIMSIMLWMTI 354
            A  NG           EL+ L+ +K+ S     +   DL R   +R +T    + W   
Sbjct: 279 VAVFNGKKEEGERLSLEELK-LNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337

Query: 355 SVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVL 414
              Y+ L++       ++++   +   V+VPA  +  L L YL R  + A AL L G  +
Sbjct: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397

Query: 415 LFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGS 474
           L +  VP DL  + TVL + GK  ++++FS +++YT+ELYPTV+R  G+GVS+  +R+GS
Sbjct: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457

Query: 475 ILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524
           ++SP     G    F+P I+ G   +L     LFLPE+   PLP+TI+ +
Sbjct: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDL 507


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  248 bits (633), Expect = 1e-65
 Identities = 176/573 (30%), Positives = 281/573 (49%), Gaps = 41/573 (7%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP-------DAA 56
           + E+   +G  G FQ L    L  SI+      +   F  A P HRC  P        A+
Sbjct: 3   FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQAS 62

Query: 57  NLSSAWRNHTVPLRLRDG-REVPHSCRRYRLATIANFSALGLEPGRDV-DLGQLEQESCL 114
            L S      + + +  G  + PH CRR+R           L+P        + + E C+
Sbjct: 63  ILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQL-----LDPNATATSWSEADTEPCV 117

Query: 115 DGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVL- 173
           DGW + + ++ STIV +WNLVC+     P+  S++  G+L+G+   G  SDRFGR+ VL 
Sbjct: 118 DGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLT 177

Query: 174 --FVTMG-MQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230
             ++ M  M T  +F   F   + +F  L      G + N     +  T    + + +  
Sbjct: 178 WSYLQMAVMGTAAAFAPAFPV-YCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL 236

Query: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290
           ++LG    ++FG+ +    AY +RDW +L + +++P  LC    W++ ES RWL++ GR 
Sbjct: 237 NSLG----FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 292

Query: 291 EEAEVIIRKAAKANGIVVPSTIFDP----SELQDLSSKKQQSHNILDLLRTWNIRMVTIM 346
           +     + + A  NG         P    S +++  S  Q   ++  LLR   +R  T +
Sbjct: 293 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI 352

Query: 347 SIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATA 406
           S + W      +FGL+LD   L  +IF+      +V++PA + A LLL +L RR ++A +
Sbjct: 353 STLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 412

Query: 407 LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVS 466
           L L G  +L   LVP ++  L + L ++G  GV AAF+ + +Y++EL+PTV+R   VG+ 
Sbjct: 413 LLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472

Query: 467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID--QM 524
             A+R G+IL P    LG +  +LP ++ G++ +L+ +  L LPE+   PLPDTI   Q 
Sbjct: 473 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQN 532

Query: 525 LRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF 557
             VK   H            G    ++LKST F
Sbjct: 533 QAVKKATH------------GTLGNSVLKSTQF 553


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  244 bits (622), Expect = 2e-64
 Identities = 165/546 (30%), Positives = 267/546 (48%), Gaps = 18/546 (3%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63
           ++++   +G  G FQ++   L+   ++          F  A P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NHTVPLRL-RDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182
            + STIVTEW+LVC       L  SL+ VGVLLG+ + G L+DR GR+ VL +   +QT 
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY-LQTA 173

Query: 183 FS-FLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241
            S     F+ NF ++    +L GM      +    L  E +    R    TL +   Y+ 
Sbjct: 174 VSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSL 232

Query: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301
           G  +L   AY +  WR L + ++ P        WF  ES RW  S GR +     +++ A
Sbjct: 233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVA 292

Query: 302 KANG-----IVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISV 356
           + NG       +   +   S  ++L+  K Q+ + ++LLR   +R + +   MLW   S 
Sbjct: 293 RINGKREEGAKLSMEVLRASLQKELTMGKGQA-SAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 357 GYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416
            Y+GL +D       I++   +   V++PA ++ +L++  L RR +   AL L G  +L 
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 417 MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 476
             ++P D   + T L ++GK  + A+F+ +++YT ELYPT++R  G+G+ ST +R+GSI+
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471

Query: 477 SPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTP 536
           SP           +P  + G++ +  + +T+ LPE+ G PLPDT+  +   KG + R+  
Sbjct: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQ 531

Query: 537 SHTRML 542
            H + +
Sbjct: 532 EHQKYM 537


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  241 bits (615), Expect = 1e-63
 Identities = 177/564 (31%), Positives = 266/564 (47%), Gaps = 38/564 (6%)

Query: 11  LGEWGPFQRLIFFLLSASIIPNGFTGLSSV---FLIATPEHRCRVPD-----AANLSSAW 62
           LG  G FQ     LL   ++P G     +    F  A P H CR P      + N S AW
Sbjct: 10  LGSMGRFQLNHTALL---LLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTNDSGAW 66

Query: 63  RNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
              T+PL   D    P  CRR+     A  S     PG          E C DGW +++ 
Sbjct: 67  LRATIPL---DQLGAPEPCRRFTKPQWALLSPNSSIPGAAT-------EGCKDGWVYNRS 116

Query: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182
           V+ STIV EW+LVCE      L  S++  GVL+G+ + G L+DR G K  L  +      
Sbjct: 117 VFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAA 176

Query: 183 FSFLQIFSKNFEMFVVLFVLVGM---GQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFY 239
                 +  +F  + V   L+GM   G I N V+  V      G++V       G+ + Y
Sbjct: 177 SGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVA------GILLGY 230

Query: 240 AF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 297
           +F  G ++L   AY IR WR L  A++ P ++     W++PES RWL+  G+ + A   +
Sbjct: 231 SFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNL 290

Query: 298 RKAAKANGIVVPSTIFDP----SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMT 353
           +K A  NG              S +Q   +    S++ILDL RT  IR VT   +++W +
Sbjct: 291 QKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFS 350

Query: 354 ISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSV 413
            SV Y+GL++D       +++   L  ++  PA ++A   + Y+ RR ++A+ L L G +
Sbjct: 351 NSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLM 410

Query: 414 LLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLG 473
           ++    VP     L T    +GK  + ++F  VY++T ELYPT +R MG+G +S  +RLG
Sbjct: 411 VIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLG 470

Query: 474 SILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLR--VKGMK 531
            + +P    LG Y   LP +  G+  IL  +    L E+   PL +TI  M R   +G  
Sbjct: 471 GLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSS 530

Query: 532 HRKTPSHTRMLKDGQERPTILKST 555
            +     +  +   Q R + LK T
Sbjct: 531 KKHVEEKSEEISLQQLRASPLKET 554


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  240 bits (612), Expect = 3e-63
 Identities = 149/422 (35%), Positives = 228/422 (54%), Gaps = 17/422 (4%)

Query: 115 DGWEFSQDVYLST----IVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 170
           +G E  + V+ S+    I +EW L+    +K     S FF GV +G    GQLSDRFGRK
Sbjct: 80  NGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRK 139

Query: 171 NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230
            V      +   F+    FS ++E F V   LVGM      + AFVL  E +G +   + 
Sbjct: 140 KVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALA 199

Query: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290
            ++G  +F+A G     L  YFIR WR L + + + G +   L  FIPESPRWL SQGR 
Sbjct: 200 GSIGG-LFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRL 258

Query: 291 EEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIML 350
            EAE  +   AK N  +     F  +   + S ++  S   LDL R   +   T++ + +
Sbjct: 259 SEAEEALYLIAKRNRKL--KCTFSLTHPANRSCRETGS--FLDLFRYRVLLGHTLILMFI 314

Query: 351 WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLL--QYLPRRYSMATALF 408
           W   S+ Y+GL+L   +L G I+ N  LS ++E+P+Y L   L+  ++  R+ +++  L 
Sbjct: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374

Query: 409 LGGSVLLFMQLVPP--DLYYLATV----LVMVGKFGVTAAFSMVYVYTAELYPTVVRNMG 462
           LGG   L +  +P   D    A V    L ++GK  ++AAF++VY+YT+ELYPTV+RN+G
Sbjct: 375 LGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434

Query: 463 VGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID 522
           +G  S  SR+G I++P+   L      LP+I+ G+  + + +L+L LPE+  +PL +T  
Sbjct: 435 LGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494

Query: 523 QM 524
            +
Sbjct: 495 DL 496


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  238 bits (606), Expect = 1e-62
 Identities = 173/489 (35%), Positives = 251/489 (51%), Gaps = 30/489 (6%)

Query: 1   MRDYDEVTAFLGEWGPFQR---LIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAAN 57
           M   D++   +GE G FQ+   LI  LLSA+  P     +  VFL  TP+H C+ P  A 
Sbjct: 1   MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAP---ICVGIVFLGFTPDHHCQSPGVAE 57

Query: 58  LSS--AWR-----NHTVPLRLRDGREVPHSCRRYRLATIANFSALG-LEPGRDV--DLGQ 107
           LS    W      N+TVP     G      CRRY +    N SAL  ++P   +  +   
Sbjct: 58  LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDW--NQSALSCVDPLASLATNRSH 115

Query: 108 LEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRF 167
           L    C DGW +  D   S+IVTE+NLVC D WK  L  S    G L GS   G  +DRF
Sbjct: 116 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173

Query: 168 GRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR 227
           GRK  L  T+ +      L  FS N+   ++  +L G+    N++A + L TE +G   R
Sbjct: 174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233

Query: 228 IIFSTLGVCIFYAF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 285
               T+ +    AF  G + L   AY +  WR L +A+++P  L +  +W +PESPRWL+
Sbjct: 234 ---RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLL 290

Query: 286 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI 345
           SQ R  EA  I+   A+ NG + P+ +   S  +D++ K   S    DL RT  +R  T 
Sbjct: 291 SQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPS--FADLFRTPRLRKRTF 348

Query: 346 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT 405
           + + LW T SV Y GL L      G+++++   SA+VE+P   +A + +  + R Y MA 
Sbjct: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408

Query: 406 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGV-- 463
           +  L G+  L M  + PDL++L  +++ VG+ G+T A  M+ +  AELYPT V  +G   
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVGPAC 468

Query: 464 -GVSSTASR 471
            G  +T+SR
Sbjct: 469 RGSDATSSR 477


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  238 bits (606), Expect = 1e-62
 Identities = 161/528 (30%), Positives = 259/528 (49%), Gaps = 18/528 (3%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63
           ++++   +G  G FQ++   L+   ++          F  A P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NHTVPLRL-RDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182
            + STIVTEW+LVC       L  SL+ VGVLLG+ + G L+DR GR+ VL +   +QT 
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY-LQTA 173

Query: 183 FS-FLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241
            S     F+ NF ++    +L GM      +    L  E +    R    TL +   Y+ 
Sbjct: 174 VSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSL 232

Query: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301
           G  +L   AY +  WR L + ++ P        WF  ES RW  S GR +     +++ A
Sbjct: 233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVA 292

Query: 302 KANG-----IVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISV 356
           + NG       +   +   S  ++L+  K Q+ + ++LLR   +R + +   MLW   S 
Sbjct: 293 RINGKREEGAKLSMEVLRASLQKELTMGKGQA-SAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 357 GYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416
            Y+GL +D       I++   +   V++PA ++ +L++  L RR +   AL L G  +L 
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 417 MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 476
             ++P D   + T L ++GK  + A+F+ +++YT ELYPT++R  G+G+ ST +R+GSI+
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471

Query: 477 SPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524
           SP           +P  + G++ +  + +T+ LPE+ G PLPDT+  +
Sbjct: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDL 519


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  223 bits (569), Expect = 3e-58
 Identities = 164/525 (31%), Positives = 258/525 (49%), Gaps = 20/525 (3%)

Query: 12  GEWGPFQRL--IFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHT--- 66
           G  G FQ L  + F+L   +IP+    L   F  A P HRC      N S+   N T   
Sbjct: 11  GGVGLFQTLQVLTFILPCLMIPSQM--LLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKA 68

Query: 67  -VPLRLRDG-REVPHSCRRYRLATIANFSALGLEPGRDV-DLGQLEQESCLDGWEFSQDV 123
            + + +  G  + PH CRR+R           L+P        + + E C+DGW + + V
Sbjct: 69  LLTISIPPGPNQGPHQCRRFRQPQWQL-----LDPNATATSWSEADTEPCVDGWVYDRSV 123

Query: 124 YLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGF 183
           + STIV +W+LVC      PL+ S+F  G+L+GSFI G LS RFGRK +L          
Sbjct: 124 FTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVA 183

Query: 184 SFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGY 243
               IF+  F ++  L  +   G    ++++  L  E    S R +  T+  C F A G 
Sbjct: 184 GTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSA-GQ 242

Query: 244 MVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKA 303
             L   A+ +RDWR L +A ++P      + W++PES RWLI +G+ ++A   +RK A+ 
Sbjct: 243 AALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARI 302

Query: 304 NGIVVPSTIFDP---SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 360
           NG      +      S +++  +  ++  ++LDL     +R  +   +++  ++ + Y+G
Sbjct: 303 NGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYG 362

Query: 361 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV 420
           L  D  +L  DIF+   L   V+        LLL +L RR   A +  + G  +L   LV
Sbjct: 363 LVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLV 422

Query: 421 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 480
           P DL  L  V  ++GK     + + + +Y AEL+PT VR    G+  T  RLG+++ P  
Sbjct: 423 PQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLI 482

Query: 481 VYLGAYDRFLPYILMGSLTILTAILTL-FLPESFGTPLPDTIDQM 524
           +        LP +L G ++I ++++ L FLPE+ G PLPDTI  +
Sbjct: 483 LMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDL 527


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  200 bits (509), Expect = 2e-51
 Identities = 153/546 (28%), Positives = 244/546 (44%), Gaps = 62/546 (11%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63
           ++++   +G  G FQ++   L+   ++          F  A P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NHTVPLRL-RDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182
            + STIVTEW+LVC       L  SL+ VGVLLG+ + G L+DR GR+ VL +   +QT 
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY-LQTA 173

Query: 183 FS-FLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241
            S     F+ NF ++    +L GM      +    L  E +    R    TL +   Y+ 
Sbjct: 174 VSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSL 232

Query: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301
           G  +L   AY +  WR L + ++ P        WF  ES RW  S GR +     +++ A
Sbjct: 233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVA 292

Query: 302 KANG-----IVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISV 356
           + NG       +   +   S  ++L+  K Q+ + ++LLR   +R + +   MLW   S 
Sbjct: 293 RINGKREEGAKLSMEVLRASLQKELTMGKGQA-SAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 357 GYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416
            Y+GL +D       I++   +   V++PA ++ +L++  L RR +   AL L G  +L 
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 417 MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 476
             ++P D   + T L ++GK  + A+F+ +++YT ELYPT++R                 
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR----------------- 454

Query: 477 SPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTP 536
                                       +T+ LPE+ G PLPDT+  +   KG + R+  
Sbjct: 455 ---------------------------AVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQ 487

Query: 537 SHTRML 542
            H + +
Sbjct: 488 EHQKYM 493


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  196 bits (498), Expect = 5e-50
 Identities = 156/538 (28%), Positives = 245/538 (45%), Gaps = 33/538 (6%)

Query: 4   YDEVTAFLGEWGPFQ--RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSA 61
           ++E+ + +G  G FQ   L+F L S  ++      L   F  A P HRC V    N + +
Sbjct: 3   FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHI--LLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 62  WRNH-----------TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQ 110
                          ++PL   D    P  CRR+       +  L L  G      + + 
Sbjct: 61  GNETGILSEDALLRISIPL---DSNLRPEKCRRF---VHPQWQLLHLN-GTIHSTSEADT 113

Query: 111 ESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 170
           E C+DGW + Q  + STIVT+W+LVC+      +   L   G+L+G  I G +SDRFGR+
Sbjct: 114 EPCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRR 173

Query: 171 NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQ---ISNYVAAFVLGTEILGKSVR 227
            +L   +           F+  F ++ VL  L G      ISN             K++ 
Sbjct: 174 FILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALV 233

Query: 228 IIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQ 287
           +I S+  + I    G ++L   AY  RDW+ L V  ++P  +   L  ++ ES RWLI  
Sbjct: 234 VILSSGALSI----GQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIIT 289

Query: 288 GRFEEAEVIIRKAAKANGIVVPSTIFD----PSELQDLSSKKQQSHNILDLLRTWNIRMV 343
            + +E    +RK A+ NGI       +     S +Q+     Q    + DL R  ++R  
Sbjct: 290 NKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKR 349

Query: 344 TIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSM 403
             + + L    ++ ++G  ++  ++  +IF+   L   V +    LA L L ++ RR S 
Sbjct: 350 ICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQ 409

Query: 404 ATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGV 463
              +FL G  +L    VP ++  L   L  +G     A FS V V+  EL PTV+R    
Sbjct: 410 ILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARAS 469

Query: 464 GVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521
           G+  TASR+G+ L+P  + L  +   LP+I+ G   I+  ++   LPE+   PLPDTI
Sbjct: 470 GIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTI 527


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  194 bits (494), Expect = 1e-49
 Identities = 158/553 (28%), Positives = 250/553 (45%), Gaps = 37/553 (6%)

Query: 4   YDEVTAFLGEWGPFQ--RLIFF-----LLSASIIPNGFTGLSSVFLIATPEHRCRVP--- 53
           +D +   +G  G FQ   + FF     LL  +I+   FT         TP HRC VP   
Sbjct: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAF-------TPSHRCWVPLLD 55

Query: 54  -------DAANLSSA-WRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDL 105
                  D   LS       ++PL   D    P  C+R+       +  L L  G   + 
Sbjct: 56  NDTVSDNDTGTLSKDDLLRISIPL---DSNLRPQKCQRF---IHPQWQLLHLN-GTFPNT 108

Query: 106 GQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSD 165
            + + E C+DGW + +  +LSTIVTEW+LVCE      +  SLF  G LLG  I G LSD
Sbjct: 109 NEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSD 168

Query: 166 RFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKS 225
           R GRK +  +        +    F+  F ++ +L  L G   ++     F+L  E     
Sbjct: 169 RVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPR 228

Query: 226 VRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 285
            R +   + +C  Y+ G M+L   A+ I+DW +L + ++ P ++     W + ES RWLI
Sbjct: 229 SRSMTIMVLLCS-YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLI 287

Query: 286 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQS----HNILDLLRTWNIR 341
              + +E    +R+ A  NG            ++    K+  +     +I  L R   +R
Sbjct: 288 INNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLR 347

Query: 342 MVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRY 401
           M       +   I+V ++GL L+  +L  ++ +   L   V   A  ++ L L ++ RR 
Sbjct: 348 MRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRI 407

Query: 402 SMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNM 461
           S     F  G  +L    +P ++  L  VL  +G   V+AA +   V+  EL PT++R+ 
Sbjct: 408 SQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRST 467

Query: 462 GVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521
             G+++ + R G+ L+P  + L AY   LP+I  G   IL   + L LPE+   PLP+TI
Sbjct: 468 VAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTI 527

Query: 522 DQMLRVKGMKHRK 534
             +   K  ++ K
Sbjct: 528 QDVENEKDSRNIK 540


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  194 bits (493), Expect = 2e-49
 Identities = 149/528 (28%), Positives = 236/528 (44%), Gaps = 62/528 (11%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWR 63
           ++++   +G  G FQ++   L+   ++          F  A P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NHTVPLRL-RDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTG 182
            + STIVTEW+LVC       L  SL+ VGVLLG+ + G L+DR GR+ VL +   +QT 
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY-LQTA 173

Query: 183 FS-FLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241
            S     F+ NF ++    +L GM      +    L  E +    R    TL +   Y+ 
Sbjct: 174 VSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSL 232

Query: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301
           G  +L   AY +  WR L + ++ P        WF  ES RW  S GR +     +++ A
Sbjct: 233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVA 292

Query: 302 KANG-----IVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISV 356
           + NG       +   +   S  ++L+  K Q+ + ++LLR   +R + +   MLW   S 
Sbjct: 293 RINGKREEGAKLSMEVLRASLQKELTMGKGQA-SAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 357 GYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416
            Y+GL +D       I++   +   V++PA ++ +L++  L RR +   AL L G  +L 
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 417 MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 476
             ++P D   + T L ++GK  + A+F+ +++YT ELYPT++R                 
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR----------------- 454

Query: 477 SPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524
                                       +T+ LPE+ G PLPDT+  +
Sbjct: 455 ---------------------------AVTVLLPETLGQPLPDTVQDL 475


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  182 bits (461), Expect = 9e-46
 Identities = 148/555 (26%), Positives = 263/555 (47%), Gaps = 50/555 (9%)

Query: 11  LGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCR----VPDAANLSSAWR-NH 65
           +GE+G FQ+ +  L     I + F   +  F+    +  C     +    +LS A + N 
Sbjct: 59  VGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNL 118

Query: 66  TVPLRLRDGREVPH----SCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQ 121
           T+P       + P+    +C  Y L    N  ++       +  G  + ++C DGW +  
Sbjct: 119 TIP-------QAPNGSFLTCFMY-LPVPWNLDSI-------IQFGLNDTDTCQDGWIYP- 162

Query: 122 DVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQT 181
           D    +++ E++LVC  + K      +F  G+ +GS I   ++D+ GR   + +++    
Sbjct: 163 DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLI 222

Query: 182 GFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241
            F F   F  +F +++     +    +   +++  L TE L    R     LG C F+A 
Sbjct: 223 IFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC-FFAV 281

Query: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301
           G ++L   AY +  W++L +   +  +  ++  W +PESPRWL+ +G+ +EA+ ++  AA
Sbjct: 282 GAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAA 341

Query: 302 KANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGL 361
             N   +PS + D  ELQ L  KK    ++LD  +   +  VT++   +W T+S  YF L
Sbjct: 342 SVNKKTIPSNLLD--ELQ-LPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTL 398

Query: 362 SLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVP 421
           SL    L   +     + +++EVPA +    LLQ + R++S+A  L       L +  +P
Sbjct: 399 SLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLP 458

Query: 422 ---------------PDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVS 466
                           +L  +  +++M+ +F + A  ++ ++YTAEL PTV+R  G+G+ 
Sbjct: 459 EGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLV 518

Query: 467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQML- 525
           S AS  G+ILS     +      LP  L   L I+   L+  LPE+   PL ++++    
Sbjct: 519 SLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQ 576

Query: 526 ---RVKGMKHRKTPS 537
              +VK MK ++T S
Sbjct: 577 IRNKVKDMKTKETSS 591


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  177 bits (450), Expect = 2e-44
 Identities = 143/535 (26%), Positives = 244/535 (45%), Gaps = 26/535 (4%)

Query: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP---------- 53
           + ++    G+   FQ L    LS   +      +   F    P HRC V           
Sbjct: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDN 62

Query: 54  DAANLSS-AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES 112
           D   LS  A    ++PL   D    P  CRR+       +  L L  G   +    + E 
Sbjct: 63  DTGALSQDALLRISIPL---DSNMRPEKCRRF---VHPQWQLLHLN-GTFPNTSDADMEP 115

Query: 113 CLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNV 172
           C+DGW + +  + STIVTEW+LVC+      +   +F  G+++G  + G LSDRFGR+ V
Sbjct: 116 CVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFV 175

Query: 173 LFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST 232
           L                +  F ++  L  L G+  +S      +L  E      + +  T
Sbjct: 176 LRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGIT 235

Query: 233 LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEE 292
           LG+C      +M L   A+ IRDW +L + +++P  +      ++ ES RWLI   + EE
Sbjct: 236 LGMCPS-GIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEE 294

Query: 293 AEVIIRKAAKANGI-----VVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNI-RMVTIM 346
               +RKAA  +G+      +   I   +  ++L + +++  ++ ++L   NI + ++++
Sbjct: 295 GLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLL 354

Query: 347 SIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATA 406
           S   +    + YFGL+L   +L  ++F+   L   V + A  +A   L+Y+ RR S    
Sbjct: 355 SFTRFANF-MAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLL 413

Query: 407 LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVS 466
           +FL    LL +  VP ++  L  VL  +G      A ++ + +  E+ PT++R   +G++
Sbjct: 414 MFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGIN 473

Query: 467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521
           +T + +   L+P  + L  Y   LP+I+ G    ++    L LPE+   PL DTI
Sbjct: 474 ATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTI 528


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  177 bits (448), Expect = 3e-44
 Identities = 155/557 (27%), Positives = 257/557 (46%), Gaps = 44/557 (7%)

Query: 11  LGEWGPFQRL-IFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP----------DAANLS 59
           +G  G FQ L + FL+  ++I    T L + F     +HRC V           D   LS
Sbjct: 10  VGGLGRFQILQMVFLIMFNVIVYHQTQLEN-FAAFILDHRCWVHILDNDTIPDNDPGTLS 68

Query: 60  S-AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWE 118
             A    ++P    D    P  CRR+           G  P    +  + + E C+DGW 
Sbjct: 69  QDALLRISIPF---DSNLRPEKCRRFVHPQWKLIHLNGTFP----NTSEPDTEPCVDGWV 121

Query: 119 FSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMG 178
           + Q  + STIVT+W+LVCE      +   LF  G+++G  + G LSDRFGRK VL     
Sbjct: 122 YDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVL----- 176

Query: 179 MQTGFSFLQI--------FSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230
               +S+LQ+        F+    ++  L  L G    S  V   +L  E +      + 
Sbjct: 177 ---RWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMA 233

Query: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290
            TL +C   + G++ L   A+ IRD  +L + ++ P  +      ++ ES RWLI   + 
Sbjct: 234 LTLTLCAA-SIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKP 292

Query: 291 EEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKK----QQSHNILDLLRTWNI-RMVTI 345
           EE    +RKAA  NG+     I     L+    ++    Q+ H++ +LLR  NI + +  
Sbjct: 293 EEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICF 352

Query: 346 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT 405
           +S + + + ++ ++GL+L   +L  ++F+   L   V + A  +A   L ++ RR S   
Sbjct: 353 LSFVRFAS-TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQML 411

Query: 406 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV 465
            +FL  + LL +  VP ++  L  VL  +G    +   +       EL P+++R    G+
Sbjct: 412 LMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGI 471

Query: 466 SSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQML 525
           +   + +G  L+   + L  Y R LP+I+ G   IL+ ++ L LPE+   PL D+I Q +
Sbjct: 472 TGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSI-QDV 530

Query: 526 RVKGMKHRKTPSHTRML 542
             +G+     P  + +L
Sbjct: 531 ENEGVNSLAAPQRSSVL 547


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  173 bits (439), Expect = 3e-43
 Identities = 108/325 (33%), Positives = 173/325 (53%), Gaps = 18/325 (5%)

Query: 239 YAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIR 298
           ++FG+ +    AY +RDW +L + +++P  LC    W++ ES RWL++ GR +     + 
Sbjct: 20  FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 79

Query: 299 KAAKANGIVVPSTIFDP----SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTI 354
           + A  NG         P    S +++  S  Q   ++  LLR   +R  T +S + W   
Sbjct: 80  RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 139

Query: 355 SVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVL 414
              +FGL+LD   L  +IF+      +V++PA + A LLL +L RR ++A +L L G  +
Sbjct: 140 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 199

Query: 415 LFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGS 474
           L   LVP ++  L + L ++G  GV AAF+ + +Y++EL+PTV+R   VG+   A+R G+
Sbjct: 200 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 259

Query: 475 ILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID--QMLRVKGMKH 532
           IL P    LG +  +LP ++ G++ +L+ +  L LPE+   PLPDTI   Q   VK   H
Sbjct: 260 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH 319

Query: 533 RKTPSHTRMLKDGQERPTILKSTAF 557
                       G    ++LKST F
Sbjct: 320 ------------GTLGNSVLKSTQF 332


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  150 bits (379), Expect = 3e-36
 Identities = 159/555 (28%), Positives = 238/555 (42%), Gaps = 50/555 (9%)

Query: 15  GPFQRLIFFLLSASIIPNGFTGL---SSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRL 71
           G F R    L SAS +P    GL   S   L A P   CR PD   L  A R    P  L
Sbjct: 12  GGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCR-PDPTLLPPALRALRGPALL 70

Query: 72  RDGREVPHSCRRYRLA-TIANFSALG-LEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIV 129
                +P      RL  T A   ALG L P     L +  + S    W            
Sbjct: 71  --DAAIP------RLGPTRAPAEALGVLSPSYLAPLTRAPRPS---SWASCSGAAAGPT- 118

Query: 130 TEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIF 189
             WNLVC D WK PL      +G LLG  I G   DRFGR+ V   ++ + TG    +  
Sbjct: 119 --WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEAL 176

Query: 190 SKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLF 249
           + +F   +VL +L G       +A ++   E+     R+ FS +G  +F   G ++LP  
Sbjct: 177 AASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGL 235

Query: 250 AYFIRDWRMLLVALTMPGVLCVALWWF---IPESPRWLISQGRFEEAEVIIRKAAKANGI 306
           A  ++DWR+L     +   L +  W F    PESP WL++ G+   A  I+ + A+A+G+
Sbjct: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 295

Query: 307 ------VVPSTIFDPSELQDLSSKKQQS--HNILDLLR---TWNIRMVTIMSIMLWMTIS 355
                 +  +++   +EL  LS++  Q   H+ L LLR   TW   ++   S ++   I 
Sbjct: 296 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR 355

Query: 356 VGY-FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVL 414
             +   L+   P      ++  FL A +E  A V   L      RR  +     + G   
Sbjct: 356 ASFRRSLAPQVPT----FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411

Query: 415 LFM----QLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470
           L +    Q +P       +VL ++    V+A  S+   + AE++PTV+R  G+G+   A 
Sbjct: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL---FAAEVFPTVIRGAGLGLVLGAG 468

Query: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI---DQMLRV 527
            LG    P     G    FL  ++  SL +L  +  L LPES    LP ++   D++ R 
Sbjct: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 528

Query: 528 KGMKHRKTPSHTRML 542
             ++ R    H  +L
Sbjct: 529 PLLRGRPRQDHLPLL 543


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  144 bits (363), Expect = 2e-34
 Identities = 122/433 (28%), Positives = 197/433 (45%), Gaps = 30/433 (6%)

Query: 132 WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSK 191
           WNLVC D WK PL      +G LLG  I G   DRFGR+ V   ++ + TG    +  + 
Sbjct: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180

Query: 192 NFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAY 251
           +F   +VL +L G       +A ++   E+     R+ FS +G  +F   G ++LP  A 
Sbjct: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 239

Query: 252 FIRDWRMLLVALTMPGVLCVALWWF---IPESPRWLISQGRFEEAEVIIRKAAKANGI-- 306
            ++DWR+L     +   L +  W F    PESP WL++ G+   A  I+ + A+A+G+  
Sbjct: 240 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 299

Query: 307 ----VVPSTIFDPSELQDLSSKKQQS--HNILDLLR---TWNIRMVTIMSIMLWMTISVG 357
               +  +++   +EL  LS++  Q   H+ L LLR   TW   ++   S ++   I   
Sbjct: 300 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAS 359

Query: 358 Y-FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLF 416
           +   L+   P      ++  FL A +E  A V   L      RR  +     + G   L 
Sbjct: 360 FRRSLAPQVPT----FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLL 415

Query: 417 M----QLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRL 472
           +    Q +P       +VL ++    V+A  S+   + AE++PTV+R  G+G+   A  L
Sbjct: 416 LLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL---FAAEVFPTVIRGAGLGLVLGAGFL 472

Query: 473 GSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI---DQMLRVKG 529
           G          G    FL  ++  SL +L  +  L LPES    LP ++   D++ R   
Sbjct: 473 GQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPL 532

Query: 530 MKHRKTPSHTRML 542
           ++ R    H  +L
Sbjct: 533 LRGRPRQDHLPLL 545


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  129 bits (325), Expect = 5e-30
 Identities = 107/426 (25%), Positives = 200/426 (46%), Gaps = 61/426 (14%)

Query: 131 EWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFS 190
           EW L   ++W+  L  ++ F G ++ S + G L+DR+GR  +L ++      FS L  F+
Sbjct: 78  EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134

Query: 191 KNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFA 250
            ++  FV L  +VG G +S +    ++ TE L    R     L    + A   +++ L +
Sbjct: 135 PSYIWFVFLRTMVGCG-VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193

Query: 251 YFIR--DWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVV 308
             I    WR L+   ++PG++ +  + FIPES R+ +S G    A   + + AK N  V+
Sbjct: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVM 253

Query: 309 PSTIFDPSELQDLSSKKQQSHNILD--LLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTP 366
           P    +   ++ +  K+ +  ++LD   LRT      T+   ++W+ IS  Y+G+ L + 
Sbjct: 254 P----EGKLVEPVLEKRGRFADLLDAKYLRT------TLQIWVIWLGISFAYYGVILASA 303

Query: 367 NL---------------------HGDIFVNCF-------------LSAMVEVPAYVLAWL 392
            L                      G+    C+             +S + E+    L  L
Sbjct: 304 ELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNIL 363

Query: 393 LLQYLPRRYSMATALFLGGSVLLFMQL-VPPDLYYLATVLVMVGKFGVTAAFSMVYVYTA 451
            + +L RR S+  ++ +G + L F+ L +      L   L M+    V A F+ VY+YTA
Sbjct: 364 GINFLGRRLSL--SITMGCTALFFLLLNICTSSAGLIGFLFMLRAL-VAANFNTVYIYTA 420

Query: 452 ELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPE 511
           E+YPT +R +G+G S +  R+G++++P+   +      +   ++G+L + +++  +    
Sbjct: 421 EVYPTTMRALGMGTSGSLCRIGAMVAPFISQV-----LMSASILGALCLFSSVCVVCAIS 475

Query: 512 SFGTPL 517
           +F  P+
Sbjct: 476 AFTLPI 481


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  128 bits (321), Expect = 2e-29
 Identities = 106/413 (25%), Positives = 189/413 (45%), Gaps = 50/413 (12%)

Query: 131 EWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFS 190
           EW L     W+  L  S+ FVG++  S + G +SD++GRK  L +++     +  L  F+
Sbjct: 114 EWRL---PSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170

Query: 191 KNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFA 250
             +   +VL  LVG G I     +  L  E L    R     L + +F+A G +   + A
Sbjct: 171 PVYSWILVLRGLVGFG-IGGVPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLA 228

Query: 251 YFIRD---WRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIV 307
            F+     WR LL+   +P +L   L +++PES R+ +  G  E+A   +++ A  NG  
Sbjct: 229 VFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAP 288

Query: 308 VPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPN 367
           +P        L  L   +Q+    +  L T + R  T++   +W + +  Y+GL L T  
Sbjct: 289 MP--------LGKLIISRQEDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTE 340

Query: 368 LH--GDI-------------------------FVNCFLSAMVEVPAYVLAWLLLQYLPRR 400
           L   GD+                         +++   + + E P  ++   ++  L R+
Sbjct: 341 LFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRK 400

Query: 401 YSMATA--LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVV 458
            +MA    +F   S+LLF+ +    L    T+L+ + +  ++  F   YVYT E+YPT  
Sbjct: 401 KTMALCFVIFSFCSLLLFICVGRNVL----TLLLFIARAFISGGFQAAYVYTPEVYPTAT 456

Query: 459 RNMGVGVSSTASRLGSILSPYFVYLGAYDR-FLPYILMGSLTILTAILTLFLP 510
           R +G+G  S  +R+G++++P+   +      +L   +     +L A+ + FLP
Sbjct: 457 RALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLP 509


>gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
           sapiens]
          Length = 495

 Score =  126 bits (317), Expect = 5e-29
 Identities = 152/547 (27%), Positives = 224/547 (40%), Gaps = 97/547 (17%)

Query: 15  GPFQRLIFFLLSASIIPNGFTGL---SSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRL 71
           G F R    L SAS +P    GL   S   L A P   CR PD   L  A R    P  L
Sbjct: 12  GGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCR-PDPTLLPPALRALRGPALL 70

Query: 72  RDGREVPHSCRRYRLA-TIANFSALG-LEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIV 129
                +P      RL  T A   ALG L P     L +  + S    W            
Sbjct: 71  --DAAIP------RLGPTRAPAEALGVLSPSYLAPLTRAPRPS---SWASCSGAAAGPT- 118

Query: 130 TEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIF 189
             WNLVC D WK PL      +G LLG  I G   DRFGR+ V   ++ + TG    +  
Sbjct: 119 --WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEAL 176

Query: 190 SKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLF 249
           + +F   +VL +L G       +A ++   E+     R+ FS +G  +F   G ++LP  
Sbjct: 177 AASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGL 235

Query: 250 AYFIRDWRMLLVALTMPGVLCVALWWF---IPESPRWLISQGRFEEAEVIIRKAAKANGI 306
           A  ++DWR+L     +   L +  W F    PESP WL++ G+   A  I+ + A+A+G+
Sbjct: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 295

Query: 307 ------VVPSTIFDPSELQDLSSKKQQS--HNILDLLRTWNIRMVTIMSIMLWMTISVGY 358
                 +  +++   +EL  LS++  Q   H+ L LLRT   R+     ++L  +  VG 
Sbjct: 296 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRT---RVTWRNGLILGFSSLVG- 351

Query: 359 FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQ 418
                      G I  N        +P +                 T LFL         
Sbjct: 352 -----------GGIRAN--------LPGW-----------------TVLFL--------- 366

Query: 419 LVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 478
                     +VL ++    V+A  S+   + AE++PTV+R  G+G+   A  LG     
Sbjct: 367 ----------SVLGLLASRAVSALSSL---FAAEVFPTVIRGAGLGLVLGAGFLGQAAGL 413

Query: 479 YFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI---DQMLRVKGMKHRKT 535
                G    FL  ++  SL +L  +  L LPES    LP ++   D++ R   ++ R  
Sbjct: 414 LDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPR 473

Query: 536 PSHTRML 542
             H  +L
Sbjct: 474 QDHLPLL 480


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.142    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,645,036
Number of Sequences: 37866
Number of extensions: 834961
Number of successful extensions: 2551
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2342
Number of HSP's gapped (non-prelim): 88
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.