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Search of human proteins with 4506999
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
(554 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 1123 0.0
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 944 0.0
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 813 0.0
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 555 e-158
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 277 2e-74
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 276 3e-74
gi|166064021 solute carrier family 22 (organic anion transporter... 266 5e-71
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 256 5e-68
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 255 8e-68
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 254 1e-67
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 243 4e-64
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 226 3e-59
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens] 224 2e-58
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 221 1e-57
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 220 2e-57
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 215 7e-56
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 214 1e-55
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 211 1e-54
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 209 7e-54
gi|211059435 solute carrier family 22, member 24 [Homo sapiens] 208 1e-53
gi|157426885 organic cation transporter like 4 [Homo sapiens] 200 2e-51
gi|148664184 solute carrier family 22, member 10 [Homo sapiens] 194 1e-49
gi|153791484 putative UST1-like organic anion transporter [Homo ... 169 8e-42
gi|42542386 solute carrier family 22 (organic anion/cation trans... 161 2e-39
gi|24308167 SV2 related protein [Homo sapiens] 157 3e-38
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens] 141 1e-33
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1... 130 3e-30
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6... 129 7e-30
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ... 125 8e-29
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ... 119 7e-27
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 1123 bits (2904), Expect = 0.0
Identities = 554/554 (100%), Positives = 554/554 (100%)
Query: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ 60
MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ
Sbjct: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ 60
Query: 61 RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120
RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP
Sbjct: 61 RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120
Query: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180
CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL
Sbjct: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180
Query: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240
GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY
Sbjct: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240
Query: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300
QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK
Sbjct: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300
Query: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360
IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL
Sbjct: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360
Query: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM 420
YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM
Sbjct: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM 420
Query: 421 IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT 480
IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT
Sbjct: 421 IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT 480
Query: 481 PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN 540
PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN
Sbjct: 481 PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN 540
Query: 541 TIYLKVQTSEPSGT 554
TIYLKVQTSEPSGT
Sbjct: 541 TIYLKVQTSEPSGT 554
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 944 bits (2441), Expect = 0.0
Identities = 462/465 (99%), Positives = 463/465 (99%)
Query: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ 60
MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ
Sbjct: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ 60
Query: 61 RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120
RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP
Sbjct: 61 RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120
Query: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180
CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL
Sbjct: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180
Query: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240
GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY
Sbjct: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240
Query: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300
QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK
Sbjct: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300
Query: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360
IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL
Sbjct: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360
Query: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM 420
YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM
Sbjct: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM 420
Query: 421 IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLG 465
IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFV +G
Sbjct: 421 IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 813 bits (2100), Expect = 0.0
Identities = 385/545 (70%), Positives = 447/545 (82%)
Query: 3 TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62
TVDD+LE GE +FQKQ F +L LLSA FAPI VGIVFLGFTPDH C+SPGVAELS RC
Sbjct: 4 TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRC 63
Query: 63 GWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQ 122
GWSPAEELNYTVPG GPAGEA QCRRYEVDWNQS CVDPLASL TNRS LPLGPC+
Sbjct: 64 GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123
Query: 123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182
DGWVY+TPGSSIVTEFNLVCA+SW LDLFQS +N GF GS+ +GY ADRFGRKLCLL T
Sbjct: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183
Query: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242
VL+NA +GVLMA SP Y ML+FRL+QGLVSK W+ GY LITEFVG RRTV I YQ+
Sbjct: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243
Query: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302
A+TVGL+ L G+AYALPHWRWLQ V+LP F FLLYYWC+PESPRWL+SQ +N EA++I+
Sbjct: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303
Query: 303 DHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQ 362
HIA+KNGK PA L+ L LEE+ +KL+PSF DL RTP++RK T ILMY WFT SVLYQ
Sbjct: 304 KHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQ 363
Query: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422
GLI+HMG N+YLDF YSALVE P AF+ ++TIDR+GR YP A SN++AGAACL +F
Sbjct: 364 GLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVF 423
Query: 423 ISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPF 482
I DL WL III C+GRMGIT+A +++CLVNAELYPTF+RNLGV +CSS+CDIGGIITPF
Sbjct: 424 IPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPF 483
Query: 483 IVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKENTI 542
+V+RL +W LPL++F VLGL+A G+ LLLPETKG ALPET+++AEN+ R K KE I
Sbjct: 484 LVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMI 543
Query: 543 YLKVQ 547
YL+VQ
Sbjct: 544 YLQVQ 548
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 555 bits (1430), Expect = e-158
Identities = 272/540 (50%), Positives = 379/540 (70%), Gaps = 12/540 (2%)
Query: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHH-CQSPGVAELS 59
MP+ D+ L++VGE G FQ++ FL+LCL FA + VG+VFLG PDH+ C+ P A L+
Sbjct: 1 MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
Query: 60 QRCGWSPAEELNYTVPGL-GPAGEAFLGQCRRYEVDWNQ------SALSCVDPLASLATN 112
+RCGWSP EE N T P GP G+C+RY ++ SALSC DPLA+ N
Sbjct: 61 ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP-N 119
Query: 113 RSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADR 172
RS PL PC+ GW Y S+IV+EF+LVC ++W LDL Q+ LN GFL G+ +GY ADR
Sbjct: 120 RS-APLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178
Query: 173 FGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGS 232
+GR + L + L V+GV++AF+PN+ ++FR LQG+ KG WM Y ++TE VGS
Sbjct: 179 YGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQ 238
Query: 233 RRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQ 292
RR V I+ QM FT+G++ L G+AY +P+W+ +QLA++LP+FLFLLYYW VPESPRWL+++
Sbjct: 239 RRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITR 298
Query: 293 KRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMY 352
K+ +A++I+ IA+ NGK ++ +++ ++ E +PSF DL RTP++RK T ILM+
Sbjct: 299 KKGDKALQILRRIAKCNGKYLSSNYSEITVTDE--EVSNPSFLDLVRTPQMRKCTLILMF 356
Query: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
WFT +V+YQGL++ +G GNLY+DF S +VE+PGA + L+TI+R+GR P A SN++
Sbjct: 357 AWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIV 416
Query: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
AG ACLV F+ + WL + +GR+GIT+A +++ LVN+ELYPT +RN GV +CS L
Sbjct: 417 AGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGL 476
Query: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLG 532
CD GGII PF++FRL VW LPLI+F +L + G+ +LLPETKG+ALPET+ D E LG
Sbjct: 477 CDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLG 536
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 277 bits (709), Expect = 2e-74
Identities = 182/544 (33%), Positives = 275/544 (50%), Gaps = 33/544 (6%)
Query: 3 TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62
T +IL++VG G FQ IL L A + +F TP HHC+ P A
Sbjct: 2 TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-- 59
Query: 63 GWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQ 122
+ +P +GP G+ +C R+ V P + N + + PC
Sbjct: 60 ---------WVLP-MGPNGKP--ERCLRF-----------VHPPNASLPNDTQRAMEPCL 96
Query: 123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182
DGWVY++ SIVTE++LVC + ++ QS AG L G L +G +DRFGR+ L +
Sbjct: 97 DGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCS 156
Query: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242
L+ A SG AFSP + ++FR L G G ++ L E+V + R ++
Sbjct: 157 YLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGY 216
Query: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302
+T G L GLAYA+P WRWLQL VS+P F+F L W PES RWL+ ++++A+KI+
Sbjct: 217 CYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276
Query: 303 DHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFT 356
+A NGK L +LK+ +E K + +DLFR P LR+ TF L WF
Sbjct: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFA 336
Query: 357 DSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAA 416
Y L + + NLY+ + V++P FI ++++ +GR A + LLAG A
Sbjct: 337 TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396
Query: 417 CLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIG 476
L + F+ DL + ++ G+ ++ + + L +ELYPT +R G+ V + +G
Sbjct: 397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVG 456
Query: 477 GIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKA- 535
+++P + EV +P I++ + LL L LPET LPET++D EN +A
Sbjct: 457 SMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAK 515
Query: 536 KPKE 539
KPK+
Sbjct: 516 KPKQ 519
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 276 bits (707), Expect = 3e-74
Identities = 195/537 (36%), Positives = 283/537 (52%), Gaps = 28/537 (5%)
Query: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAP---ICVGIVFLGFTPDHHCQSPGVAE 57
M D++ +GE G FQ+ LI LLSA+ P + VFL TP+H C+ P A
Sbjct: 1 MRDYDEVTAFLGEWGPFQR---LIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAAN 57
Query: 58 LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDW--NQSALSCVDPLASLATNRSH 115
LS W N+TVP G CRRY + N SAL ++P + +
Sbjct: 58 LSS--AWR-----NHTVPLRLRDGREVPHSCRRYRLATIANFSALG-LEPGRDV--DLGQ 107
Query: 116 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173
L C DGW + D S+IVTE+NLVC D WK L S G L GS G +DRF
Sbjct: 108 LEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRF 167
Query: 174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233
GRK L T+ + L FS N+ ++ +L G+ N++A + L TE +G R
Sbjct: 168 GRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR 227
Query: 234 ---RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLL 290
T+ + AF G + L AY + WR L +A+++P L + +W +PESPRWL+
Sbjct: 228 IIFSTLGVCIFYAF--GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 285
Query: 291 SQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPS--FADLFRTPRLRKRTF 348
SQ R EA I+ A+ NG + P+ + S +D++ K S DL RT +R T
Sbjct: 286 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI 345
Query: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408
+ + LW T SV Y GL L G+++++ SA+VE+P +A + + + R Y MA
Sbjct: 346 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT 405
Query: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 468
+ L G+ L M + PDL++L +++ VG+ G+T A M+ + AELYPT VRN+GV V
Sbjct: 406 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV 465
Query: 469 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETM 525
S+ +G I++P+ V+ L + LP IL L +L A +TL LPE+ G LP+T+
Sbjct: 466 SSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 266 bits (679), Expect = 5e-71
Identities = 186/554 (33%), Positives = 276/554 (49%), Gaps = 28/554 (5%)
Query: 7 ILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSP 66
+L ++G+ G FQ Q ++LC+L+ VF+ HHC V + S
Sbjct: 7 VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVK--NHTFNLSA 64
Query: 67 AEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126
AE+L +VP L AG C + A + + + S N + PC GW
Sbjct: 65 AEQLVLSVP-LDTAGHP--EPCLMFRPP---PANASLQDILSHRFNETQ----PCDMGWE 114
Query: 127 Y-DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLV 185
Y + S+ EFNLVC D QS AG L G+L G DR GRK +L +L+
Sbjct: 115 YPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174
Query: 186 NAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFT 245
+ G+ AF P++ + R G + TL+TE+VG R ++ Q F+
Sbjct: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234
Query: 246 VGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHI 305
+G + L GLAY +WR LQ+ + P L Y+W +PES RWLL++ R EAI+++
Sbjct: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294
Query: 306 AQKN-GKLPPADLKMLSLEEDVTEKLSPS--FADLFRTPRLRKRTFILMYLWFTDSVLYQ 362
A N KL P + L V EK PS DLFR P+LRK T I+ +WF DS+ Y
Sbjct: 295 ASVNRRKLSPELMNQL-----VPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYY 349
Query: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422
GL L +G ++YL L VE+P ++ + R GR + + +L G C+++IF
Sbjct: 350 GLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIF 409
Query: 423 ISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPF 482
I DL + ++ VG+M A + + +AEL+PT +R G+ + IGGI+TP
Sbjct: 410 IPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPL 469
Query: 483 IVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLG-----RKAKP 537
++ L E ALP++++ L ++A + LLPET G L +T++D E LG K+ P
Sbjct: 470 VIL-LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE-LGPHPRSPKSVP 527
Query: 538 KENTIYLKVQTSEP 551
E K +TS P
Sbjct: 528 SEKETEAKGRTSSP 541
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 256 bits (653), Expect = 5e-68
Identities = 178/544 (32%), Positives = 267/544 (49%), Gaps = 34/544 (6%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG- 63
+D+L+QVG G FQ+ ++ L A F P HHC+ P A LS+ G
Sbjct: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
Query: 64 --WSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGP 120
W P + C R+ W L+ + + AT P
Sbjct: 64 EVWLPRDRQGQPE------------SCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
Query: 121 CQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLC 178
C DGW+YD T S+IVTE++LVC+ L QS G L G++ GY ADR GR+
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
Query: 179 LLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238
L+ L AVSG AF+PN+ FRLL G+ G + TL E++ +R V
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
Query: 239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEA 298
+ +++G L G+AYA+PHWR LQL VS P F F +Y W ES RW S R
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
Query: 299 IKIMDHIAQKNGKLPP-ADLKM----LSLEEDVT-EKLSPSFADLFRTPRLRKRTFILMY 352
++ + +A+ NGK A L M SL++++T K S +L R P LR L
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
Query: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
LWF S Y GL++ + ++YL + V++P + + I+ +GR + LL
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
Query: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
AG L+ I D + + +G+ + + I L ELYPT +R G+ + S++
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464
Query: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLG 532
+G I++P +V E++ ++PL ++ + + A+ VT+LLPET G LP+T++D E+
Sbjct: 465 ARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES-- 521
Query: 533 RKAK 536
RK K
Sbjct: 522 RKGK 525
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 255 bits (651), Expect = 8e-68
Identities = 175/538 (32%), Positives = 264/538 (49%), Gaps = 32/538 (5%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG- 63
+D+L+QVG G FQ+ ++ L A F P HHC+ P A LS+ G
Sbjct: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
Query: 64 --WSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGP 120
W P + C R+ W L+ + + AT P
Sbjct: 64 EVWLPRDRQGQPE------------SCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
Query: 121 CQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLC 178
C DGW+YD T S+IVTE++LVC+ L QS G L G++ GY ADR GR+
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
Query: 179 LLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238
L+ L AVSG AF+PN+ FRLL G+ G + TL E++ +R V
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
Query: 239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEA 298
+ +++G L G+AYA+PHWR LQL VS P F F +Y W ES RW S R
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
Query: 299 IKIMDHIAQKNGKLPP-ADLKM----LSLEEDVT-EKLSPSFADLFRTPRLRKRTFILMY 352
++ + +A+ NGK A L M SL++++T K S +L R P LR L
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
Query: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
LWF S Y GL++ + ++YL + V++P + + I+ +GR + LL
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
Query: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
AG L+ I D + + +G+ + + I L ELYPT +R G+ + S++
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464
Query: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAEN 530
+G I++P +V E++ ++PL ++ + + A+ VT+LLPET G LP+T++D E+
Sbjct: 465 ARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 254 bits (649), Expect = 1e-67
Identities = 189/555 (34%), Positives = 278/555 (50%), Gaps = 29/555 (5%)
Query: 1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPIC---VGIVFLGFTPDHHCQSPGVAE 57
M D+++ +GE G FQ+ LI LLSA+ P + +VFL TP+H C+ P A
Sbjct: 1 MRDYDEVIAFLGEWGPFQR---LIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAAN 57
Query: 58 LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDW--NQSALSCVDPLASLATNRSH 115
LS W N +VP G C RY + N SAL ++P + +
Sbjct: 58 LSS--AWR-----NNSVPLRLRDGREVPHSCSRYRLATIANFSALG-LEPGRDV--DLGQ 107
Query: 116 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173
L C DGW + D S++VTE+NLVC D+WK+ L S G L GS G +DRF
Sbjct: 108 LEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRF 167
Query: 174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233
GRK L T+ V L FS ++ + ++ G+ N++ + L TE +G R
Sbjct: 168 GRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR 227
Query: 234 RTVAIMYQMAF-TVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQ 292
+ + F VG + L AY + WR L LA+++P L + +W +PESPRWL+SQ
Sbjct: 228 IIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQ 287
Query: 293 KRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFA-DLFRTPRLRKRTFILM 351
+R EA I+ A+ N PA + S+EE K +F DLFRT + T + +
Sbjct: 288 RRFREAEDIIQKAAKMNNIAVPAVI-FDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSL 346
Query: 352 YLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNL 411
LW SV Y L L G+ YL+ SAL+EIP A + + + R Y +A
Sbjct: 347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 406
Query: 412 LAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSS 471
G L + + D ++L+I ++ +G+ GIT A M+ + AELYPT VRN+ V V S+
Sbjct: 407 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTST 466
Query: 472 LCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENL 531
+G II P+ V+ L + LP I+ L +L +TL PE+ G+ LPET++ + +
Sbjct: 467 ASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKV 525
Query: 532 -----GRKAKPKENT 541
G+K + T
Sbjct: 526 KWFRSGKKTRDSMET 540
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 243 bits (619), Expect = 4e-64
Identities = 177/566 (31%), Positives = 268/566 (47%), Gaps = 33/566 (5%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAE---LSQR 61
+ I + VG G FQ+ + I + + + VF+G TP H C+ PG
Sbjct: 7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNH 66
Query: 62 CGWS--------PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNR 113
WS + + +Y L L +C R + + N S+L ++
Sbjct: 67 SNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRE-NTSSLG-----YEYTGSK 120
Query: 114 SHLPLGPCQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFAD 171
PC DG++YD T S+ VT++NLVC W L Q G L GS+ GYF+D
Sbjct: 121 KEF---PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSD 177
Query: 172 RFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSG 231
R GR++ L T + G+ AF+ +Y + + R +V+ G + G+ + EF+G
Sbjct: 178 RLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMK 237
Query: 232 SRRTVAIMYQMAFTVG--LVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWL 289
SR ++ F VG LVALTG Y + W Q+ +S T F+L W +PE+P WL
Sbjct: 238 SRTWASVHLHSFFAVGTLLVALTG--YLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295
Query: 290 LSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLE------EDVTEKLSPSFADLFRTPRL 343
LS+ R EA KI+D +A+ N ++LSL+ TE + + LF +
Sbjct: 296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSI 355
Query: 344 RKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRI 403
KRT + +WFT S+ + L+ GN YL+ +VEIP I +D+VGR
Sbjct: 356 TKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRR 415
Query: 404 YPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRN 463
+A S + AC V++ I + L ++ VG+ I A +I L AELYPT VR+
Sbjct: 416 TVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRS 475
Query: 464 LGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPE 523
L V S +C + I+ PF V L +W +P + + LL+ +TL LPET G L
Sbjct: 476 LAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLAT 534
Query: 524 TMKDAENLGRKAKPKENTIYLKVQTS 549
T ++A L + + K + + L S
Sbjct: 535 TWEEAAKLESENESKSSKLLLTTNNS 560
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 226 bits (577), Expect = 3e-59
Identities = 167/549 (30%), Positives = 252/549 (45%), Gaps = 37/549 (6%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGV-AELSQRCG 63
+++LEQVG G FQ + +L L + +FL P H C PG A S +
Sbjct: 4 EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
Query: 64 WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123
W A L + L C R+ + + S PC
Sbjct: 64 WLEAH--------LPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
Query: 124 GWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLG 181
GW YD S+I TE++LVC + AG L G++ GY +DRFGR+ LL
Sbjct: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175
Query: 182 TVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLIT-----EFVGSGSRRTV 236
+ V G+ A S +Y+ + R L G +AG+T+I E++ R
Sbjct: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSA-----LAGFTIIVMPLELEWLDVEHRTVA 230
Query: 237 AIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNT 296
++ +T G++ L + Y + WRWL LAV+LP +L W VPES RWLL+Q
Sbjct: 231 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVK 290
Query: 297 EAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLS--------PSFADLFRTPRLRKRTF 348
EA + + H A+ NG+ D S ++ K++ PS+ DLFRTPRLR +
Sbjct: 291 EAHRYLLHCARLNGRPVCED----SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL 346
Query: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408
+ +WF + Y GL L + N+Y L VE+P + +++ GR A
Sbjct: 347 CCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAG 406
Query: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 468
+ L A + +S D+ + ++ +G+ A L +ELYPT +R G+ +
Sbjct: 407 TLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 466
Query: 469 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDA 528
+ + +GG + P L VW +LP + + + LLAAG LLLPET+ LPET++D
Sbjct: 467 TALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDV 525
Query: 529 ENLGRKAKP 537
E RK+ P
Sbjct: 526 E---RKSAP 531
>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
Length = 553
Score = 224 bits (570), Expect = 2e-58
Identities = 172/541 (31%), Positives = 254/541 (46%), Gaps = 29/541 (5%)
Query: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFT---PDHHCQSP----GVAEL 58
++L+ VG G FQ L L + +C + F+ P H C +P A+
Sbjct: 5 ELLDLVGGLGRFQ---VLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQA 61
Query: 59 SQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPL 118
S SP L ++P P QCRR+ Q +DP A+ AT+ S
Sbjct: 62 SILGSLSPEALLAISIP---PGPNQRPHQCRRFR----QPQWQLLDPNAT-ATSWSEADT 113
Query: 119 GPCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRK 176
PC DGWVYD S+IV ++NLVC + QS AG L G+ G +DRFGR+
Sbjct: 114 EPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRR 173
Query: 177 LCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTV 236
L L + L AV G AF+P + LFR L G M TL+ E+ + +R V
Sbjct: 174 LVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLV 233
Query: 237 AIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNT 296
+ + F+ G +AY + W LQL VS+P FL LY W + ES RWLL+ R
Sbjct: 234 MTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLD 293
Query: 297 EAIKIMDHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFIL 350
++ + +A NGK L P L EE + S L R P LR RT I
Sbjct: 294 WGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCIS 353
Query: 351 MYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSN 410
WF + GL L + A N++L ++ +V+IP AL+ + +GR +A S
Sbjct: 354 TLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASL 413
Query: 411 LLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCS 470
LLAG L + ++ L + +G G+ A I + ++EL+PT +R V +
Sbjct: 414 LLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQ 473
Query: 471 SLCDIGGIITPFI-VFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAE 529
G I+ P + + + W LPL+++ + +L+ LLLPET+ + LP+T++D +
Sbjct: 474 MAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 531
Query: 530 N 530
N
Sbjct: 532 N 532
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 221 bits (564), Expect = 1e-57
Identities = 167/551 (30%), Positives = 252/551 (45%), Gaps = 39/551 (7%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGV-AELSQRCG 63
+++LEQVG G FQ + +L L + +FL P H C PG A S +
Sbjct: 4 EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
Query: 64 WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123
W A L + L C R+ + + S PC
Sbjct: 64 WLEAH--------LPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
Query: 124 GWVYDTP--GSSIVTE--FNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL 179
GW YD S+I TE ++LVC + AG L G++ GY +DRFGR+ L
Sbjct: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175
Query: 180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLIT-----EFVGSGSRR 234
L + V G+ A S +Y+ + R L G +AG+T+I E++ R
Sbjct: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSA-----LAGFTIIVMPLELEWLDVEHRT 230
Query: 235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKR 294
++ +T G++ L + Y + WRWL LAV+LP +L W VPES RWLL+Q
Sbjct: 231 VAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGH 290
Query: 295 NTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLS--------PSFADLFRTPRLRKR 346
EA + + H A+ NG+ D S ++ K++ PS+ DLFRTPRLR
Sbjct: 291 VKEAHRYLLHCARLNGRPVCED----SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHI 346
Query: 347 TFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPM 406
+ + +WF + Y GL L + N+Y L VE+P + +++ GR
Sbjct: 347 SLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQ 406
Query: 407 AMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGV 466
A + L A + +S D+ + ++ +G+ A L +ELYPT +R G+
Sbjct: 407 AGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGM 466
Query: 467 MVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMK 526
+ + + +GG + P L VW +LP + + + LLAAG LLLPET+ LPET++
Sbjct: 467 GLTALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQ 525
Query: 527 DAENLGRKAKP 537
D E RK+ P
Sbjct: 526 DVE---RKSAP 533
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 220 bits (561), Expect = 2e-57
Identities = 167/551 (30%), Positives = 254/551 (46%), Gaps = 38/551 (6%)
Query: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIV--FLGFTPDHHCQSPG---VAELSQ 60
D+L+ +G G FQ +L L A C + F P HHC+ P A +
Sbjct: 5 DLLDALGSMGRFQLNHTALLLLPCGLLA--CHNFLQNFTAAVPPHHCRGPANHTEASTND 62
Query: 61 RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120
W L T+P L G CRR+ P +L + S +P
Sbjct: 63 SGAW-----LRATIP-LDQLGAP--EPCRRF-----------TKPQWALLSPNSSIPGAA 103
Query: 121 ---CQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGR 175
C+DGWVY+ S+IV E++LVC DL QS AG L G+ G ADR G
Sbjct: 104 TEGCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGC 163
Query: 176 KLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRT 235
K L+ + L A SG A+ ++ + +FR L G+ G + +L+ E++ + R
Sbjct: 164 KGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTV 223
Query: 236 VAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRN 295
I+ +FT+G + L G+AY + WR LQ A+S P +F LY W +PES RWLL ++
Sbjct: 224 AGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKS 283
Query: 296 TEAIKIMDHIAQKNG------KLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFI 349
A++ + +A NG +L + E + S S DLFRTP +RK T
Sbjct: 284 QLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCC 343
Query: 350 LMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMS 409
LM +WF++SV Y GL + + +LYL ++ P +A T+ VGR +A
Sbjct: 344 LMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASF 403
Query: 410 NLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVC 469
+LAG + +F+ L +G+ + + + L ELYPT +R +G+
Sbjct: 404 LILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFA 463
Query: 470 SSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAE 529
S +GG+ P +V L E LP + F +LA +L ET+ + L ET+ E
Sbjct: 464 SVHARLGGLTAP-LVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522
Query: 530 NLGRKAKPKEN 540
++ K++
Sbjct: 523 RRVKEGSSKKH 533
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 215 bits (548), Expect = 7e-56
Identities = 168/544 (30%), Positives = 240/544 (44%), Gaps = 78/544 (14%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG- 63
+D+L+QVG G FQ+ ++ L A F P HHC+ P A LS+ G
Sbjct: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
Query: 64 --WSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGP 120
W P + C R+ W L+ + + AT P
Sbjct: 64 EVWLPRDRQGQPE------------SCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
Query: 121 CQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLC 178
C DGW+YD T S+IVTE++LVC+ L QS G L G++ GY ADR GR+
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
Query: 179 LLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238
L+ L AVSG AF+PN+ FRLL G+ G + TL E++ +R V
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
Query: 239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEA 298
+ +++G L G+AYA+PHWR LQL VS P F F +Y W ES RW S R
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
Query: 299 IKIMDHIAQKNGKLPP-ADLKM----LSLEEDVT-EKLSPSFADLFRTPRLRKRTFILMY 352
++ + +A+ NGK A L M SL++++T K S +L R P LR L
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
Query: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
LWF S Y GL++ + ++YL + V++P + + I+ +GR + LL
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
Query: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
AG L+ I D + + +G+ + + I L ELYPT +R
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR---------- 454
Query: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLG 532
VT+LLPET G LP+T++D E+
Sbjct: 455 -----------------------------------AVTVLLPETLGQPLPDTVQDLES-- 477
Query: 533 RKAK 536
RK K
Sbjct: 478 RKGK 481
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 214 bits (546), Expect = 1e-55
Identities = 165/538 (30%), Positives = 237/538 (44%), Gaps = 76/538 (14%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG- 63
+D+L+QVG G FQ+ ++ L A F P HHC+ P A LS+ G
Sbjct: 4 NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63
Query: 64 --WSPAEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGP 120
W P + C R+ W L+ + + AT P
Sbjct: 64 EVWLPRDRQGQPE------------SCLRFTSPQWGLPFLNGTEANGTGATE-------P 104
Query: 121 CQDGWVYD--TPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLC 178
C DGW+YD T S+IVTE++LVC+ L QS G L G++ GY ADR GR+
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164
Query: 179 LLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238
L+ L AVSG AF+PN+ FRLL G+ G + TL E++ +R V
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224
Query: 239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEA 298
+ +++G L G+AYA+PHWR LQL VS P F F +Y W ES RW S R
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284
Query: 299 IKIMDHIAQKNGKLPP-ADLKM----LSLEEDVT-EKLSPSFADLFRTPRLRKRTFILMY 352
++ + +A+ NGK A L M SL++++T K S +L R P LR L
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344
Query: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412
LWF S Y GL++ + ++YL + V++P + + I+ +GR + LL
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404
Query: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
AG L+ I D + + +G+ + + I L ELYPT +R
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR---------- 454
Query: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAEN 530
VT+LLPET G LP+T++D E+
Sbjct: 455 -----------------------------------AVTVLLPETLGQPLPDTVQDLES 477
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 211 bits (538), Expect = 1e-54
Identities = 161/533 (30%), Positives = 257/533 (48%), Gaps = 18/533 (3%)
Query: 7 ILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ-RCGWS 65
+LEQ G G FQ L L + F P H C + + S +
Sbjct: 6 LLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMT 65
Query: 66 PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGW 125
P L ++P P QCRR+ Q +DP A+ AT+ S PC DGW
Sbjct: 66 PKALLTISIP---PGPNQGPHQCRRFR----QPQWQLLDPNAT-ATSWSEADTEPCVDGW 117
Query: 126 VYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTV 183
VYD S+IV +++LVC+ L QS +G L GS G + RFGRK L
Sbjct: 118 VYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCC 177
Query: 184 LVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMA 243
L AV+G F+P ++ R + G +++ TL+ E+ + R + A
Sbjct: 178 LQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCA 237
Query: 244 FTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMD 303
F+ G AL GLA+AL WR LQLA S+P F L W +PES RWL+ + + +A++ +
Sbjct: 238 FSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELR 297
Query: 304 HIAQKNG----KLPPADLKMLSLEEDVTEKLSP-SFADLFRTPRLRKRTFILMYLWFTDS 358
+A+ NG K ++ M S++E+V P S DLF P LR R+ ++ + F+
Sbjct: 298 KVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLL 357
Query: 359 VLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACL 418
+ Y GL+ + + +++L V+ G + + +GR A S +AG A L
Sbjct: 358 ISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAIL 417
Query: 419 VMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGI 478
+ + DL L ++ +G+ I++ + + AEL+PT VR + ++ +G +
Sbjct: 418 ANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAM 477
Query: 479 ITPFIVFRLREVWQALPLILFAVLGLLAAGVTL-LLPETKGVALPETMKDAEN 530
+ P I+ R+ LP +L+ V+ + ++ V L LPET+G+ LP+T++D E+
Sbjct: 478 MGPLILMS-RQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLES 529
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 209 bits (531), Expect = 7e-54
Identities = 163/537 (30%), Positives = 254/537 (47%), Gaps = 53/537 (9%)
Query: 4 VDDILEQVGESGWFQKQ-AFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62
V++ + VGE G +Q FL+ LL A + I +G TP +H
Sbjct: 3 VEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH------------- 49
Query: 63 GWSPAEELNYTVPGLGPAGE--AFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120
W AE L G AGE AF DW L N S +
Sbjct: 50 -WDLAELLPNQSHGNQSAGEDQAF--------GDW------------LLTANGSEI---- 84
Query: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180
+ + +SI +E+ L+ S+K+ S +G G + G +DRFGRK L
Sbjct: 85 -HKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYL 143
Query: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240
++ + + FSP+Y + R L G+++ G + + L+ E VG+ +
Sbjct: 144 TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG 203
Query: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300
+ F VG+ L Y + WR L + V+L + L +PESPRWL SQ R +EA +
Sbjct: 204 GLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEE 263
Query: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360
+ IA++N KL L+ + + + + SF DLFR L T ILM++WF S++
Sbjct: 264 ALYLIAKRNRKLKCT--FSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLV 321
Query: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDR--VGRIYPMAMSNLLAGAACL 418
Y GL L G G++Y + S L+EIP + + I++ GR ++ L G ACL
Sbjct: 322 YYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACL 381
Query: 419 VMIFI--SPDLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472
+++F+ D ++ + +G++ I+ A ++ + +ELYPT +RN+G+ CS
Sbjct: 382 IVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMF 441
Query: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAE 529
+GGII PFI L+ V +LP I+F GL + ++LLLPET L ET D +
Sbjct: 442 SRVGGIIAPFIP-SLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
Length = 551
Score = 208 bits (529), Expect = 1e-53
Identities = 160/558 (28%), Positives = 248/558 (44%), Gaps = 29/558 (5%)
Query: 5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP----GVAELSQ 60
D +L+QVG G FQ C+ + P V F FTP H C P +
Sbjct: 4 DVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND 63
Query: 61 RCGWSPAEELNYTVP---GLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHL 116
S + L ++P L P +C+R+ W L+ P N +
Sbjct: 64 TGTLSKDDLLRISIPLDSNLRPQ------KCQRFIHPQWQLLHLNGTFP------NTNEP 111
Query: 117 PLGPCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFG 174
PC DGWVYD S+IVTE++LVC + QS AG L G L G+ +DR G
Sbjct: 112 DTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVG 171
Query: 175 RKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRR 234
RK+ L A+S AF+P ++ + R L G + + L E+ SR
Sbjct: 172 RKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRS 231
Query: 235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKR 294
++ +++VG + L GLA+A+ W LQL VS P + L W + ES RWL+ +
Sbjct: 232 MTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQ 291
Query: 295 NTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEK------LSPSFADLFRTPRLRKRTF 348
E +K + +A NGK + L +K + S LFR P+LR R F
Sbjct: 292 LDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVF 351
Query: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408
L ++ F +V + GLIL++ N+ L + V ++L+T++ +GR +
Sbjct: 352 GLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQIL 411
Query: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 468
G LV F+ ++ L +++ +G ++ A + + EL PT +R+ +
Sbjct: 412 FTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGI 471
Query: 469 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDA 528
+ G + P ++ L LP I + V +LA V LLLPET+ + LP T++D
Sbjct: 472 NAVSGRTGAALAP-LLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDV 530
Query: 529 ENLGRKAKPKENTIYLKV 546
EN K+ +KV
Sbjct: 531 ENEKDSRNIKQEDTCMKV 548
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 200 bits (509), Expect = 2e-51
Identities = 153/549 (27%), Positives = 259/549 (47%), Gaps = 38/549 (6%)
Query: 6 DILEQVGESGWFQKQ--AFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG 63
++L+ VGE G FQ++ A + + +AF VF P +C + + +
Sbjct: 54 NLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP--YCNTSWILAVGPHL- 110
Query: 64 WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123
S AE+LN T+P P G +FL V WN +D + N + CQD
Sbjct: 111 -SKAEQLNLTIPQ-APNG-SFLTCFMYLPVPWN------LDSIIQFGLNDTDT----CQD 157
Query: 124 GWVY-DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182
GW+Y D S++ EF+LVC K D Q AG GSL D+ GR +L +
Sbjct: 158 GWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
Query: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242
+L + G AF ++ L FR G ++ +L TE++ R I+
Sbjct: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
Query: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302
F VG V LTG+AY+LPHW+ L L + F+ Y W +PESPRWL+ + + EA +++
Sbjct: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337
Query: 303 DHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQ 362
+ A N K P++L + L+ + S D + +L K T ++ +WFT S Y
Sbjct: 338 CYAASVNKKTIPSNL-LDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYF 396
Query: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422
L L M +++ + +++E+P + + ++GR + +A++ L A CL+++F
Sbjct: 397 TLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLF 456
Query: 423 I---------------SPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVM 467
+ + +L + I+++ + + + + L AEL PT +R G+
Sbjct: 457 LPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLG 516
Query: 468 VCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKD 527
+ S G I++ I+ + + LP+ L VL ++A ++ LLPET+ L E++
Sbjct: 517 LVSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNH 573
Query: 528 AENLGRKAK 536
+ + K K
Sbjct: 574 SSQIRNKVK 582
>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
Length = 541
Score = 194 bits (494), Expect = 1e-49
Identities = 128/428 (29%), Positives = 212/428 (49%), Gaps = 11/428 (2%)
Query: 120 PCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL 177
PC DGWVYD S+IVT+++LVC + Q L G L G + G+ +DRFGR+
Sbjct: 115 PCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRF 174
Query: 178 CLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA 237
L +L A++ AF+P + + R L G S ITE++ S+ V
Sbjct: 175 ILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVV 234
Query: 238 IMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTE 297
I+ A ++G + L GLAY W+ L + S+P F+F L + ES RWL+ + E
Sbjct: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294
Query: 298 AIKIMDHIAQKNG-KLPPADLKMLSLEEDVTEKL-----SPSFADLFRTPRLRKRTFILM 351
+K + +A+ NG K L + + + E+L + DLFR P +RKR IL+
Sbjct: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILV 354
Query: 352 YLWFTDSVLYQGLILHMGATSGNLY-LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSN 410
+L F +++ + G ++++ N++ L LY A+ I +AL+T++ +GR +
Sbjct: 355 FLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRC-LALLTLNHMGRRISQILFM 413
Query: 411 LLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCS 470
L G + L F+ ++ L + + C+G + + EL PT +R +
Sbjct: 414 FLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDL 473
Query: 471 SLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAEN 530
+ IG + P ++ L + LP I++ + ++ + LLPETK + LP+T+KD EN
Sbjct: 474 TASRIGAALAP-LLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVEN 532
Query: 531 LGRKAKPK 538
+ K K
Sbjct: 533 QKKNLKEK 540
>gi|153791484 putative UST1-like organic anion transporter [Homo
sapiens]
Length = 547
Score = 169 bits (427), Expect = 8e-42
Identities = 144/551 (26%), Positives = 236/551 (42%), Gaps = 45/551 (8%)
Query: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWS 65
D+L+QVG G FQ + L + + F F DH C W
Sbjct: 5 DLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRC-------------WV 51
Query: 66 PAEELNYTVPGLGP---AGEAFLG------------QCRRY-EVDWNQSALSCVDPLASL 109
+ N T+P P + +A L +CRR+ W L+ P
Sbjct: 52 HILD-NDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFP---- 106
Query: 110 ATNRSHLPLGPCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVG 167
N S PC DGWVYD S+IVT+++LVC + + AG + G G
Sbjct: 107 --NTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYG 164
Query: 168 YFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEF 227
+ +DRFGRK L + L A+ G AF+P + R L G + + LI E+
Sbjct: 165 HLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEW 224
Query: 228 VGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPR 287
+ + A ++G + L LA+ + LQL +S P F+F L+ + ES R
Sbjct: 225 ITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESAR 284
Query: 288 WLLSQKRNTEAIKIMDHIAQKNGKLPPAD-LKMLSLEEDVTEKLSP-----SFADLFRTP 341
WL+ + E +K + A +NG D L M L+ + ++L S +L R P
Sbjct: 285 WLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIP 344
Query: 342 RLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVG 401
+ KR L ++ F ++ + GL LH+ N++L V + +A ++ +
Sbjct: 345 NICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMS 404
Query: 402 RIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFV 461
R + L L +IF+ ++ L +++ +G ++ I EL P+ +
Sbjct: 405 RRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSII 464
Query: 462 RNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVAL 521
R + + +IGG + ++ L + LP I++ V +L+ V LLLPET+ L
Sbjct: 465 RGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPL 523
Query: 522 PETMKDAENLG 532
++++D EN G
Sbjct: 524 LDSIQDVENEG 534
>gi|42542386 solute carrier family 22 (organic anion/cation
transporter), member 9 [Homo sapiens]
Length = 553
Score = 161 bits (407), Expect = 2e-39
Identities = 121/464 (26%), Positives = 209/464 (45%), Gaps = 21/464 (4%)
Query: 87 QCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYD--TPGSSIVTEFNLVCA 143
+CRR+ W L+ P N S + PC DGWVYD + S+IVTE++LVC
Sbjct: 87 KCRRFVHPQWQLLHLNGTFP------NTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCD 140
Query: 144 DSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSML 203
+ + AG + G + G+ +DRFGR+ L L A+ G A +P ++
Sbjct: 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYC 200
Query: 204 LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRW 263
R L G+ + LI E+ + + + + L GLA+A+ W
Sbjct: 201 SLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHI 260
Query: 264 LQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSL- 322
LQL VS+P F+ L + ES RWL+ + E +K + A ++G D L +
Sbjct: 261 LQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEIL 320
Query: 323 ------EEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLY 376
E + +K PS ++ P + KR +L + F + + Y GL LH+ N++
Sbjct: 321 KSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVF 380
Query: 377 -LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIM 435
L L+ A++ + +A + + R + L L +IF+ ++ L ++
Sbjct: 381 LLQTLFGAVILLANC-VAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLA 439
Query: 436 CVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALP 495
+G +A + E+ PT +R + + ++ +I G + P ++ L LP
Sbjct: 440 TLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMI-LSVYSPPLP 498
Query: 496 LILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKE 539
I++ V ++ LLLPET+ L +T++D +N + P+E
Sbjct: 499 WIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKN--ERKDPRE 540
>gi|24308167 SV2 related protein [Homo sapiens]
Length = 548
Score = 157 bits (396), Expect = 3e-38
Identities = 124/411 (30%), Positives = 197/411 (47%), Gaps = 40/411 (9%)
Query: 145 SWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLL 204
SW++ L S + G + S G +D++GRK L +VL G+L AF+P Y +L+
Sbjct: 119 SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILV 178
Query: 205 FRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLA-YALPH--W 261
R L G G TL EF+ +R ++ ++ + +G V LA + +P W
Sbjct: 179 LRGLVGF-GIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGW 237
Query: 262 RWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLS 321
RWL + ++P LF + + +PES R+ + +AI + IA +NG P ++S
Sbjct: 238 RWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIIS 297
Query: 322 LEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL------HMGATSG-- 373
+ED DLF TP R T +L ++WF+++ Y GL+L G G
Sbjct: 298 RQED-----RGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGIS 351
Query: 374 -------------------NLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAG 414
Y+D L++ L E PG + L IDR+GR MA+ ++
Sbjct: 352 SRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIF- 410
Query: 415 AACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCD 474
+ C +++FI + L +++ + R I+ Q + E+YPT R LG+ CS +
Sbjct: 411 SFCSLLLFICVGRNVLTLLLF-IARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMAR 469
Query: 475 IGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLP-ETKGVALPET 524
+G +ITPFI + E L L +++ LLAA + LP ETKG L E+
Sbjct: 470 VGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520
>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
Length = 332
Score = 141 bits (356), Expect = 1e-33
Identities = 96/312 (30%), Positives = 152/312 (48%), Gaps = 9/312 (2%)
Query: 226 EFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPES 285
E+ + +R V + + F+ G +AY + W LQL VS+P FL LY W + ES
Sbjct: 2 EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61
Query: 286 PRWLLSQKRNTEAIKIMDHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFR 339
RWLL+ R ++ + +A NGK L P L EE + S L R
Sbjct: 62 ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLR 121
Query: 340 TPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDR 399
P LR RT I WF + GL L + A N++L ++ +V+IP AL+ +
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH 181
Query: 400 VGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPT 459
+GR +A S LLAG L + ++ L + +G G+ A I + ++EL+PT
Sbjct: 182 LGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 241
Query: 460 FVRNLGVMVCSSLCDIGGIITPFI-VFRLREVWQALPLILFAVLGLLAAGVTLLLPETKG 518
+R V + G I+ P + + + W LPL+++ + +L+ LLLPET+
Sbjct: 242 VLRMTAVGLGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQS 299
Query: 519 VALPETMKDAEN 530
+ LP+T++D +N
Sbjct: 300 LPLPDTIQDVQN 311
>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
[Homo sapiens]
Length = 558
Score = 130 bits (327), Expect = 3e-30
Identities = 139/545 (25%), Positives = 229/545 (42%), Gaps = 50/545 (9%)
Query: 27 LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79
L SA++ P I +G+V L P HC+ P + + R PA L+ +P LGP
Sbjct: 21 LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
Query: 80 AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFN 139
AL + P R+ P W G++ +N
Sbjct: 80 TRAP-------------AEALGVLSPSYLAPLTRAPRP-----SSWA-SCSGAAAGPTWN 120
Query: 140 LVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNY 199
LVC D WK+ L Q G+L G + +G DRFGR+ + ++++ G A + ++
Sbjct: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
Query: 200 MSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALP 259
++L+ RLL G G +A Y E R ++ + VG + L GLA +
Sbjct: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
Query: 260 HWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP--- 313
WR LQ +L + L LL++ PESP WLL+ + A KI+ A+ +G P
Sbjct: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
Query: 314 ---------PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGL 364
+L MLS SP L RT + IL + +
Sbjct: 301 SLEENSLATATELTMLSARSPQPRYHSP--LGLLRTRVTWRNGLILGFSSLVGGGIRASF 358
Query: 365 ILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFIS 424
+ YL + A +E L+T D GR + + ++ G A L+++ +
Sbjct: 359 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 418
Query: 425 PDL-HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFI 483
L W + + +G + + L AE++PT +R G+ + +G P
Sbjct: 419 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLD 478
Query: 484 VFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGR----KAKPKE 539
R+ + L ++FA L +LA LLLPE++ LP++++DA+ L R + +P++
Sbjct: 479 TLHGRQGF-FLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQ 537
Query: 540 NTIYL 544
+ + L
Sbjct: 538 DHLPL 542
>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
[Homo sapiens]
Length = 560
Score = 129 bits (324), Expect = 7e-30
Identities = 140/546 (25%), Positives = 234/546 (42%), Gaps = 50/546 (9%)
Query: 27 LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79
L SA++ P I +G+V L P HC+ P + + R PA L+ +P LGP
Sbjct: 21 LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
Query: 80 AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNR-SHLPLGPCQDGWVYDTPGSSIVTEF 138
++A C+ PL L+ + + L P W G++ +
Sbjct: 80 T----------------RAASPCL-PLGVLSPSYLAPLTRAPRPSSWA-SCSGAAAGPTW 121
Query: 139 NLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPN 198
NLVC D WK+ L Q G+L G + +G DRFGR+ + ++++ G A + +
Sbjct: 122 NLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAAS 181
Query: 199 YMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258
+ ++L+ RLL G G +A Y E R ++ + VG + L GLA +
Sbjct: 182 FPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALV 241
Query: 259 PHWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP-- 313
WR LQ +L + L LL++ PESP WLL+ + A KI+ A+ +G P
Sbjct: 242 QDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGD 301
Query: 314 ----------PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQG 363
+L MLS SP L RT + IL + +
Sbjct: 302 SSLEENSLATATELTMLSARSPQPRYHSP--LGLLRTRVTWRNGLILGFSSLVGGGIRAS 359
Query: 364 LILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI 423
+ YL + A +E L+T D GR + + ++ G A L+++
Sbjct: 360 FRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 419
Query: 424 SPDL-HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPF 482
+ L W + + +G + + L AE++PT +R G+ + +G
Sbjct: 420 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLL 479
Query: 483 IVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGR----KAKPK 538
R+ + L ++FA L +LA LLLPE++ LP++++DA+ L R + +P+
Sbjct: 480 DTLHGRQGF-FLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPR 538
Query: 539 ENTIYL 544
++ + L
Sbjct: 539 QDHLPL 544
>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
sapiens]
Length = 520
Score = 125 bits (315), Expect = 8e-29
Identities = 125/429 (29%), Positives = 193/429 (44%), Gaps = 27/429 (6%)
Query: 121 CQDGWVYDTPGSSIVT-----EFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGR 175
C W Y+ G ++T +++LVC W++ L Q GF G L +GY ADRFGR
Sbjct: 70 CLKDWDYN--GLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGR 127
Query: 176 KLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRT 235
+ +L T+ + GV A + + ++ R L G + G + Y + E R
Sbjct: 128 RGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLR 187
Query: 236 VAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYW--CVPESPRWLLSQK 293
VA+ ++ G GLA WR+LQ ++ P LFL Y W ES RWL+ ++
Sbjct: 188 VALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKR 247
Query: 294 RNTEAIKIMDHIAQKN-------GKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKR 346
+ EA ++ +A++N G+ L+ L + S SFA L + K
Sbjct: 248 QIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKN 307
Query: 347 TFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIAL----ITIDRVGR 402
L+ L FT+ + + + G DF +L+ A +A +T+DR GR
Sbjct: 308 ---LLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGR 364
Query: 403 IYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCV-GRMGITIAIQMICLVNAELYPTFV 461
+ +S L G A LV++ + L+ I V G A + L+ AE+ PT V
Sbjct: 365 RGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTV 424
Query: 462 RNLGVMVCSSLCDIGGIITPFIVFRLREVWQA-LPLILFAVLGLLAAGVTLLLPETKGVA 520
R G+ + +L +GG+ P RL A L ++ A LL +LLPETK
Sbjct: 425 RGRGLGLIMALGALGGLSGP--AQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKL 482
Query: 521 LPETMKDAE 529
LPE ++D E
Sbjct: 483 LPEVLRDGE 491
>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
sapiens]
Length = 538
Score = 119 bits (298), Expect = 7e-27
Identities = 126/447 (28%), Positives = 195/447 (43%), Gaps = 45/447 (10%)
Query: 121 CQDGWVYDTPGSSIVT-----EFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGR 175
C W Y+ G ++T +++LVC W++ L Q GF G L +GY ADRFGR
Sbjct: 70 CLKDWDYN--GLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGR 127
Query: 176 KLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRT 235
+ +L T+ + GV A + + ++ R L G + G + Y + E R
Sbjct: 128 RGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLR 187
Query: 236 VAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYW--CVPESPRWLLSQK 293
VA+ ++ G GLA WR+LQ ++ P LFL Y W ES RWL+ ++
Sbjct: 188 VALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKR 247
Query: 294 RNTEAIKIMDHIAQKN-------GKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKR 346
+ EA ++ +A++N G+ L+ L + S SFA L + K
Sbjct: 248 QIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKN 307
Query: 347 TFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIAL----ITIDRVGR 402
L+ L FT+ + + + G DF +L+ A +A +T+DR GR
Sbjct: 308 ---LLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGR 364
Query: 403 IYPMAMSNLLAGAACLVMIFI------------------SPDLHWLNIIIMCV-GRMGIT 443
+ +S L G A LV++ + + DL+ I V G
Sbjct: 365 RGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQ 424
Query: 444 IAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQA-LPLILFAVL 502
A + L+ AE+ PT VR G+ + +L +GG+ P RL A L ++ A
Sbjct: 425 AAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP--AQRLHMGHGAFLQHVVLAAC 482
Query: 503 GLLAAGVTLLLPETKGVALPETMKDAE 529
LL +LLPETK LPE ++D E
Sbjct: 483 ALLCILSIMLLPETKRKLLPEVLRDGE 509
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.141 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,064,451
Number of Sequences: 37866
Number of extensions: 939565
Number of successful extensions: 2750
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2498
Number of HSP's gapped (non-prelim): 117
length of query: 554
length of database: 18,247,518
effective HSP length: 107
effective length of query: 447
effective length of database: 14,195,856
effective search space: 6345547632
effective search space used: 6345547632
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.