Guide to the Human Genome
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Search of human proteins with 4506183

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
         (255 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]        509   e-144
gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]       488   e-138
gi|23110942 proteasome alpha 5 subunit [Homo sapiens]                 126   2e-29
gi|4506189 proteasome alpha 7 subunit [Homo sapiens]                  125   3e-29
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]       122   4e-28
gi|23110944 proteasome alpha 6 subunit [Homo sapiens]                 117   1e-26
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]       115   4e-26
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]             111   5e-25
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]      111   7e-25
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]        111   7e-25
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]         97   1e-20
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]        97   1e-20
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]        81   1e-15
gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]       77   2e-14
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]       63   2e-10
gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]             60   2e-09
gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]             60   2e-09
gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]             60   2e-09
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]        33   0.24 
gi|212276078 leucine rich repeat (in FLII) interacting protein 1...    30   1.6  
gi|50428925 cytoskeleton associated protein 1 [Homo sapiens]           30   1.6  
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]     30   2.0  
gi|115529463 protein kinase D1 [Homo sapiens]                          28   5.9  
gi|55749742 HEAT repeat containing 5B [Homo sapiens]                   28   5.9  
gi|24308089 chromodomain helicase DNA binding protein 5 [Homo sa...    28   5.9  
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]         28   5.9  
gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens]        28   7.8  
gi|23308729 zinc finger protein 268 [Homo sapiens]                     28   7.8  
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          28   7.8  
gi|157671915 guanylate binding protein family, member 6 [Homo sa...    28   7.8  

>gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
          Length = 255

 Score =  509 bits (1310), Expect = e-144
 Identities = 255/255 (100%), Positives = 255/255 (100%)

Query: 1   MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE 60
           MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
Sbjct: 1   MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE 60

Query: 61  EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV 120
           EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
Sbjct: 61  EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV 120

Query: 121 HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL 180
           HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
Sbjct: 121 HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL 180

Query: 181 QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 240
           QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
Sbjct: 181 QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 240

Query: 241 KESLKEEDESDDDNM 255
           KESLKEEDESDDDNM
Sbjct: 241 KESLKEEDESDDDNM 255


>gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]
          Length = 248

 Score =  488 bits (1256), Expect = e-138
 Identities = 248/255 (97%), Positives = 248/255 (97%), Gaps = 7/255 (2%)

Query: 1   MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE 60
           MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
Sbjct: 1   MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE 60

Query: 61  EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV 120
           EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
Sbjct: 61  EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV 120

Query: 121 HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL 180
           HAYTLYSAVRPFGC       SVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
Sbjct: 121 HAYTLYSAVRPFGC-------SVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL 173

Query: 181 QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 240
           QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
Sbjct: 174 QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 233

Query: 241 KESLKEEDESDDDNM 255
           KESLKEEDESDDDNM
Sbjct: 234 KESLKEEDESDDDNM 248


>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
          Length = 241

 Score =  126 bits (317), Expect = 2e-29
 Identities = 76/215 (35%), Positives = 121/215 (56%), Gaps = 7/215 (3%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD   +TFSP+GR+FQVEYA++A++  STAIGI+  +GV   VEK + S L E  S +++
Sbjct: 8   YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKI 67

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
             +D H+G A++GL+ADA++L D AR E  N    +   + ++ +   V+     +    
Sbjct: 68  VEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEED 127

Query: 128 A-----VRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQM 182
           A      RPFG + + G      G QL+ +DPSG        AIG A + A++ ++++  
Sbjct: 128 ADPGAMSRPFGVALLFGGVD-EKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYH 186

Query: 183 KEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWV 217
           K MT ++ +K    I+  V +E K  A  +EL+ V
Sbjct: 187 KSMTLKEAIKSSLIILKQVMEE-KLNATNIELATV 220


>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
          Length = 248

 Score =  125 bits (315), Expect = 3e-29
 Identities = 79/250 (31%), Positives = 137/250 (54%), Gaps = 18/250 (7%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD + + FSPDG +FQVEYA +AV+  STA+G+R +D VV GVEK  ++KL +E + +++
Sbjct: 3   YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKI 62

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
             +D +V MA AGL ADAR + + AR E  + R      + ++++   +A     YT  +
Sbjct: 63  CALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSN 122

Query: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEK------LQ 181
             RPFG S ++  +  +   +LY  DPSG  + +   AIG+  ++ +  +EK      ++
Sbjct: 123 GRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIE 182

Query: 182 MKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAK 241
             ++T + ++K + +++     +   K  EL +         R + +     EE EKY  
Sbjct: 183 TDDLTIKLVIKALLEVV-----QSGGKNIELAVM-------RRDQSLKILNPEEIEKYVA 230

Query: 242 ESLKEEDESD 251
           E  KE++E++
Sbjct: 231 EIEKEKEENE 240


>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
          Length = 250

 Score =  122 bits (305), Expect = 4e-28
 Identities = 79/245 (32%), Positives = 135/245 (55%), Gaps = 8/245 (3%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD + + FSPDG +FQVEYA +AV+  STA+GIR  + VV GVEK  ++KL +E + +++
Sbjct: 5   YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
             +D HV MA AGL ADAR + + AR E  + +      + ++++   +A     YT  +
Sbjct: 65  CALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 124

Query: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 187
             RPFG S ++  +  +  ++LY  DPSG  + +   AIG++ +  +  +EK   ++   
Sbjct: 125 GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIA 184

Query: 188 RDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKE 246
            D   E  K+ I  + + V+     +EL+ +      R++ +     +E E Y  E  KE
Sbjct: 185 SD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYVTEIEKE 237

Query: 247 EDESD 251
           ++E++
Sbjct: 238 KEEAE 242


>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
          Length = 246

 Score =  117 bits (293), Expect = 1e-26
 Identities = 62/179 (34%), Positives = 97/179 (54%), Gaps = 1/179 (0%)

Query: 7   GYDLSASTFSPDGRVFQVEYAMKAVENSS-TAIGIRCKDGVVFGVEKLVLSKLYEEGSNK 65
           G+D   + FSP+GR++QVEYA KA+     T++ +R KD  V   +K V  KL +  +  
Sbjct: 8   GFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVT 67

Query: 66  RLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTL 125
            LF +  ++G  + G+ AD+RS    AR EA+N++  +GY IP+  L  R+A     YT 
Sbjct: 68  HLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ 127

Query: 126 YSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKE 184
            + +RP GC  +L       G Q+Y  DP+G   G+   A G  +  + + +EK   K+
Sbjct: 128 NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKK 186


>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
          Length = 256

 Score =  115 bits (288), Expect = 4e-26
 Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 14/251 (5%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD + + FSPDG +FQVEYA +AV+  STA+GIR  + VV GVEK  ++KL +E + +++
Sbjct: 5   YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64

Query: 68  FNVDRHVGMAVA------GLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVH 121
             +D HV MA A      GL ADAR + + AR E  + +      + ++++   +A    
Sbjct: 65  CALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQ 124

Query: 122 AYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQ 181
            YT  +  RPFG S ++  +  +  ++LY  DPSG  + +   AIG++ +  +  +EK  
Sbjct: 125 KYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNY 184

Query: 182 MKEMTCRDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 240
            ++    D   E  K+ I  + + V+     +EL+ +      R++ +     +E E Y 
Sbjct: 185 TEDAIASD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYV 237

Query: 241 KESLKEEDESD 251
            E  KE++E++
Sbjct: 238 TEIEKEKEEAE 248


>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
          Length = 234

 Score =  111 bits (278), Expect = 5e-25
 Identities = 64/186 (34%), Positives = 100/186 (53%), Gaps = 3/186 (1%)

Query: 7   GYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKR 66
           GY  S +TFSP G++ Q+EYA+ AV   + ++GI+  +GVV   EK   S LY+E S  +
Sbjct: 5   GYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHK 64

Query: 67  LFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLY 126
           +  + +H+G+  +G+  D R L   AR+ A  +   +   IP   L  RVA  +  YT  
Sbjct: 65  VEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQS 124

Query: 127 SAVRPFGCSFMLGSYSVNDG-AQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEM 185
             VRPFG S ++  +  N+G   L+  DPSG  + +   A+GK     KT +EK   +++
Sbjct: 125 GGVRPFGVSLLICGW--NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDL 182

Query: 186 TCRDIV 191
              D +
Sbjct: 183 ELEDAI 188


>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
          Length = 261

 Score =  111 bits (277), Expect = 7e-25
 Identities = 76/258 (29%), Positives = 128/258 (49%), Gaps = 16/258 (6%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEE-GSNKR 66
           YD   + FSP+GR++QVEYAM+A+ ++ T +GI   DGV+   E+  + KL +E   +++
Sbjct: 5   YDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEK 64

Query: 67  LFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLY 126
           ++ ++  +  +VAG+ +DA  L +  R  A  +   +   IP + L   +     AYT +
Sbjct: 65  IYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQF 124

Query: 127 SAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMK--E 184
              RPFG S +   +  + G QLY  DPSG +YG W         AA   + K   K  E
Sbjct: 125 GGKRPFGVSLLYIGWDKHYGFQLYQSDPSG-NYGGWKATCIGNNSAAAVSMLKQDYKEGE 183

Query: 185 MTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGR-----------HEIVPKDIR 233
           MT +  +    K++    D  K  A ++E++ +    NG+            +++ K   
Sbjct: 184 MTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTR-ENGKTVIRVLKQKEVEQLIKKHEE 242

Query: 234 EEAEKYAKESLKEEDESD 251
           EEA+   ++  KE+ E D
Sbjct: 243 EEAKAEREKKEKEQKEKD 260


>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
          Length = 261

 Score =  111 bits (277), Expect = 7e-25
 Identities = 76/258 (29%), Positives = 128/258 (49%), Gaps = 16/258 (6%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEE-GSNKR 66
           YD   + FSP+GR++QVEYAM+A+ ++ T +GI   DGV+   E+  + KL +E   +++
Sbjct: 5   YDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEK 64

Query: 67  LFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLY 126
           ++ ++  +  +VAG+ +DA  L +  R  A  +   +   IP + L   +     AYT +
Sbjct: 65  IYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQF 124

Query: 127 SAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMK--E 184
              RPFG S +   +  + G QLY  DPSG +YG W         AA   + K   K  E
Sbjct: 125 GGKRPFGVSLLYIGWDKHYGFQLYQSDPSG-NYGGWKATCIGNNSAAAVSMLKQDYKEGE 183

Query: 185 MTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGR-----------HEIVPKDIR 233
           MT +  +    K++    D  K  A ++E++ +    NG+            +++ K   
Sbjct: 184 MTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTR-ENGKTVIRVLKQKEVEQLIKKHEE 242

Query: 234 EEAEKYAKESLKEEDESD 251
           EEA+   ++  KE+ E D
Sbjct: 243 EEAKAEREKKEKEQKEKD 260


>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
          Length = 263

 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 55/180 (30%), Positives = 91/180 (50%), Gaps = 3/180 (1%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD   + +SP GR+ Q+EYAM+AV+  S  +G++ K   V    K   S+L      K++
Sbjct: 6   YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQKKI 63

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
            +VD H+G+++AGL ADAR L +  R+E  + R  F   +P+  L   +       T   
Sbjct: 64  LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 123

Query: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 187
             RP+G   ++  Y  + G  ++   PS   +     +IG   Q+A+T +E+   + M C
Sbjct: 124 GRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMEC 182


>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
          Length = 269

 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 55/180 (30%), Positives = 91/180 (50%), Gaps = 3/180 (1%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD   + +SP GR+ Q+EYAM+AV+  S  +G++ K   V    K   S+L      K++
Sbjct: 12  YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQKKI 69

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
            +VD H+G+++AGL ADAR L +  R+E  + R  F   +P+  L   +       T   
Sbjct: 70  LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 129

Query: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 187
             RP+G   ++  Y  + G  ++   PS   +     +IG   Q+A+T +E+   + M C
Sbjct: 130 GRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMEC 188


>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
          Length = 212

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 64/245 (26%), Positives = 111/245 (45%), Gaps = 46/245 (18%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD + + FSPDG +FQVEYA +AV+  STA+GIR                          
Sbjct: 5   YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIR-------------------------- 38

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
                       GL ADAR + + AR E  + +      + ++++   +A     YT  +
Sbjct: 39  ------------GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 86

Query: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 187
             RPFG S ++  +  +  ++LY  DPSG  + +   AIG++ +  +  +EK   ++   
Sbjct: 87  GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIA 146

Query: 188 RDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKE 246
            D   E  K+ I  + + V+     +EL+ +      R++ +     +E E Y  E  KE
Sbjct: 147 SD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYVTEIEKE 199

Query: 247 EDESD 251
           ++E++
Sbjct: 200 KEEAE 204


>gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]
          Length = 130

 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 39/109 (35%), Positives = 62/109 (56%), Gaps = 2/109 (1%)

Query: 8   YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
           YD   + +SP GR+ Q+EYAM+AV+  S  +G++ K   V    K   S+L      K++
Sbjct: 6   YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQKKI 63

Query: 68  FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRV 116
            +VD H+G+++AGL ADAR L +  R+E  + R  F   +P+  L   +
Sbjct: 64  LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLI 112


>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
          Length = 190

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 15/188 (7%)

Query: 77  AVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSF 136
           +VAG+ +DA  L +  R  A  +   +   IP + L   +     AYT +   RPFG S 
Sbjct: 4   SVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSL 63

Query: 137 MLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMK--EMTCRDIVKEV 194
           +   +  + G QLY  DPSG +YG W         AA   + K   K  EMT +  +   
Sbjct: 64  LYIGWDKHYGFQLYQSDPSG-NYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALA 122

Query: 195 AKIIYIVHDEVKDKAFELELSWVGELTNGR-----------HEIVPKDIREEAEKYAKES 243
            K++    D  K  A ++E++ +    NG+            +++ K   EEA+   ++ 
Sbjct: 123 IKVLNKTMDVSKLSAEKVEIATLTR-ENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKK 181

Query: 244 LKEEDESD 251
            KE+ E D
Sbjct: 182 EKEQKEKD 189


>gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]
          Length = 272

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 56/98 (57%), Gaps = 3/98 (3%)

Query: 6   TGYDLSASTFSPDGRVFQVEYAMKAV-ENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSN 64
           TG+D     FSP  +++QV+YA KA+ +   T++ +R KD  V    K+V  KL +  S 
Sbjct: 91  TGFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLD--SR 148

Query: 65  KRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSN 102
             LF + ++ G  + G+ AD+RS    A+ +A+N + N
Sbjct: 149 THLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYN 186


>gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]
          Length = 272

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 56/98 (57%), Gaps = 3/98 (3%)

Query: 6   TGYDLSASTFSPDGRVFQVEYAMKAV-ENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSN 64
           TG+D     FSP  +++QV+YA KA+ +   T++ +R KD  V    K+V  KL +  S 
Sbjct: 91  TGFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLD--SR 148

Query: 65  KRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSN 102
             LF + ++ G  + G+ AD+RS    A+ +A+N + N
Sbjct: 149 THLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYN 186


>gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]
          Length = 272

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 34/98 (34%), Positives = 56/98 (57%), Gaps = 3/98 (3%)

Query: 6   TGYDLSASTFSPDGRVFQVEYAMKAV-ENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSN 64
           TG+D     FSP  +++QV+YA KA+ +   T++ +R KD  V    K+V  KL +  S 
Sbjct: 91  TGFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLD--SR 148

Query: 65  KRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSN 102
             LF + ++ G  + G+ AD+RS    A+ +A+N + N
Sbjct: 149 THLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYN 186


>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
          Length = 732

 Score = 33.1 bits (74), Expect = 0.24
 Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 9   DLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLF 68
           +LS    +PDGR  Q+   + +    +  +G+R     +FG   + L+  +E GS+ R  
Sbjct: 598 ELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFG-NNVTLASKFESGSHPRRI 656

Query: 69  NV 70
           NV
Sbjct: 657 NV 658


>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
           isoform 1 [Homo sapiens]
          Length = 640

 Score = 30.4 bits (67), Expect = 1.6
 Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 20/85 (23%)

Query: 169 ARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIV 228
           A++AA+ E  +++MKE+      +   K IY    +V+ K + L+  W G++        
Sbjct: 39  AKRAARAEAREIRMKEL------ERQQKEIY----QVQKKYYGLDTKW-GDI-------- 79

Query: 229 PKDIREEAEKYAKESLKEEDESDDD 253
            +   E++E+Y++ S +    SD+D
Sbjct: 80  -EQWMEDSERYSRRSRRNTSASDED 103


>gi|50428925 cytoskeleton associated protein 1 [Homo sapiens]
          Length = 244

 Score = 30.4 bits (67), Expect = 1.6
 Identities = 12/24 (50%), Positives = 18/24 (75%)

Query: 137 MLGSYSVNDGAQLYMIDPSGVSYG 160
           +LGSY V+DG ++++ID SG   G
Sbjct: 73  LLGSYPVDDGCRIHVIDHSGARLG 96


>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
          Length = 1312

 Score = 30.0 bits (66), Expect = 2.0
 Identities = 13/21 (61%), Positives = 16/21 (76%)

Query: 234 EEAEKYAKESLKEEDESDDDN 254
           EEAE+  +E  +EEDE DDDN
Sbjct: 540 EEAEEEEEEEEEEEDEDDDDN 560


>gi|115529463 protein kinase D1 [Homo sapiens]
          Length = 912

 Score = 28.5 bits (62), Expect = 5.9
 Identities = 17/56 (30%), Positives = 26/56 (46%)

Query: 81  LLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSF 136
           LL  + S + I RE+ SN +S  G  I L  +        H + ++S  RP  C +
Sbjct: 231 LLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQY 286


>gi|55749742 HEAT repeat containing 5B [Homo sapiens]
          Length = 2071

 Score = 28.5 bits (62), Expect = 5.9
 Identities = 11/27 (40%), Positives = 18/27 (66%)

Query: 227  IVPKDIREEAEKYAKESLKEEDESDDD 253
            +V  +I++EAE   K ++K  D+ DDD
Sbjct: 1431 VVAMNIKKEAESKPKRAIKNTDDDDDD 1457


>gi|24308089 chromodomain helicase DNA binding protein 5 [Homo
           sapiens]
          Length = 1954

 Score = 28.5 bits (62), Expect = 5.9
 Identities = 11/25 (44%), Positives = 18/25 (72%)

Query: 230 KDIREEAEKYAKESLKEEDESDDDN 254
           K ++++ EK AK   K+EDE D+D+
Sbjct: 101 KKLKDKKEKKAKRKKKDEDEDDNDD 125


>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
          Length = 1317

 Score = 28.5 bits (62), Expect = 5.9
 Identities = 20/80 (25%), Positives = 38/80 (47%), Gaps = 13/80 (16%)

Query: 170 RQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVP 229
           +++ K E+E++Q +  T R   + V   I    + +K ++F +E                
Sbjct: 623 QKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKL------------- 669

Query: 230 KDIREEAEKYAKESLKEEDE 249
           KD+  E EK+ +E L+E+ E
Sbjct: 670 KDLLAEKEKFEEERLREQQE 689


>gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens]
          Length = 679

 Score = 28.1 bits (61), Expect = 7.8
 Identities = 17/56 (30%), Positives = 30/56 (53%)

Query: 200 IVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM 255
           IVH   KDK    E   V + + G  +   +++ + AEKYA+E  ++++  +  NM
Sbjct: 529 IVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNM 584


>gi|23308729 zinc finger protein 268 [Homo sapiens]
          Length = 947

 Score = 28.1 bits (61), Expect = 7.8
 Identities = 28/120 (23%), Positives = 52/120 (43%), Gaps = 8/120 (6%)

Query: 125 LYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCA-IGKARQAAKTEIEKLQM- 182
           +++ V+P+GCS    ++S+   +QL +   S      +GC+  GKA ++    I  ++  
Sbjct: 661 VHTGVKPYGCSQCAKTFSLK--SQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTH 718

Query: 183 ---KEMTCRDIVKEVA-KIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEK 238
              K   CR+  K  +     IVH  +       E S  G+  N + +++        EK
Sbjct: 719 TGEKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEK 778


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 28.1 bits (61), Expect = 7.8
 Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 19/83 (22%)

Query: 169 ARQAAKTEIEKLQM--KEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHE 226
           A++  KT I+K +   KE   +++ KE+ K      +E K+   E+           + E
Sbjct: 661 AKKEDKTPIKKEEKPKKEEVKKEVKKEIKK------EEKKEPKKEV-----------KKE 703

Query: 227 IVPKDIREEAEKYAKESLKEEDE 249
             PK++++E +K  K+ +K+E++
Sbjct: 704 TPPKEVKKEVKKEEKKEVKKEEK 726


>gi|157671915 guanylate binding protein family, member 6 [Homo
           sapiens]
          Length = 633

 Score = 28.1 bits (61), Expect = 7.8
 Identities = 27/122 (22%), Positives = 48/122 (39%), Gaps = 9/122 (7%)

Query: 135 SFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEV 194
           S   GS+SV  G +LYM     +   YW   + +    AK   ++    +M   + + + 
Sbjct: 420 SISAGSFSVPGGHKLYMETKERIEQDYW--QVPRKGVKAKEVFQRFLESQMVIEESILQS 477

Query: 195 AKII-----YIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA--KESLKEE 247
            K +      +  D  K +A E E   + +    + + +    +   E  A  KE L+ E
Sbjct: 478 DKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQME 537

Query: 248 DE 249
            E
Sbjct: 538 RE 539


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,544,727
Number of Sequences: 37866
Number of extensions: 333861
Number of successful extensions: 1496
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1447
Number of HSP's gapped (non-prelim): 39
length of query: 255
length of database: 18,247,518
effective HSP length: 100
effective length of query: 155
effective length of database: 14,460,918
effective search space: 2241442290
effective search space used: 2241442290
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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