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Search of human proteins with 4506179
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
(263 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 532 e-151
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] 530 e-151
gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens] 228 5e-60
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] 141 7e-34
gi|4506189 proteasome alpha 7 subunit [Homo sapiens] 138 6e-33
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] 134 6e-32
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] 121 7e-28
gi|23110942 proteasome alpha 5 subunit [Homo sapiens] 121 7e-28
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] 113 1e-25
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 106 2e-23
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 106 2e-23
gi|23110944 proteasome alpha 6 subunit [Homo sapiens] 104 7e-23
gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] 97 1e-20
gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens] 91 8e-19
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] 69 4e-12
gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens] 48 8e-06
gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens] 48 8e-06
gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens] 48 8e-06
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens] 35 0.087
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] 34 0.15
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens] 33 0.25
gi|83921609 hypothetical protein LOC127254 [Homo sapiens] 33 0.25
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 30 2.8
gi|7705344 DNA-directed DNA polymerase kappa [Homo sapiens] 30 2.8
gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 29 4.8
gi|210032509 hypothetical protein LOC100130302 [Homo sapiens] 29 4.8
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 28 6.2
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 28 6.2
gi|16905522 golgi SNAP receptor complex member 2 isoform A [Homo... 28 6.2
gi|16905520 golgi SNAP receptor complex member 2 isoform B [Homo... 28 6.2
>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
Length = 263
Score = 532 bits (1370), Expect = e-151
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 1 MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
Sbjct: 1 MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60
Query: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT 120
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
Sbjct: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT 120
Query: 121 QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 180
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
Sbjct: 121 QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 180
Query: 181 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP 240
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
Sbjct: 181 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP 240
Query: 241 QRKAQPAQPADEPAEKADEPMEH 263
QRKAQPAQPADEPAEKADEPMEH
Sbjct: 241 QRKAQPAQPADEPAEKADEPMEH 263
>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
Length = 269
Score = 530 bits (1365), Expect = e-151
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 2 FRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK 61
FRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK
Sbjct: 8 FRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK 67
Query: 62 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 121
KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ
Sbjct: 68 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 127
Query: 122 RYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 181
RYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME
Sbjct: 128 RYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 187
Query: 182 CNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQ 241
CNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQ
Sbjct: 188 CNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQ 247
Query: 242 RKAQPAQPADEPAEKADEPMEH 263
RKAQPAQPADEPAEKADEPMEH
Sbjct: 248 RKAQPAQPADEPAEKADEPMEH 269
>gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]
Length = 130
Score = 228 bits (580), Expect = 5e-60
Identities = 114/114 (100%), Positives = 114/114 (100%)
Query: 1 MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
Sbjct: 1 MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60
Query: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGS 114
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGS
Sbjct: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGS 114
>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
Length = 250
Score = 141 bits (355), Expect = 7e-34
Identities = 78/241 (32%), Positives = 139/241 (57%), Gaps = 7/241 (2%)
Query: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 61
++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + +
Sbjct: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
Query: 62 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 121
KI +D+H+ ++ AGLTADAR++ N R EC + + P+ V + I + Q TQ
Sbjct: 63 KICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQ 122
Query: 122 RYGRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 180
GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE++ +E
Sbjct: 123 SNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDA 182
Query: 181 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP 240
+ +E +K ++AL E + + KN+ + I+ ++ ++ +V ++ +E+
Sbjct: 183 IASDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEK 238
Query: 241 Q 241
+
Sbjct: 239 E 239
>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
Length = 248
Score = 138 bits (347), Expect = 6e-33
Identities = 79/246 (32%), Positives = 139/246 (56%), Gaps = 7/246 (2%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--KKI 63
YD +TV+SP G + Q+EYA EAVK+GS VG++ + VL K++ ++L + +KI
Sbjct: 3 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKI 62
Query: 64 LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 123
+D+++ ++ AGLTADAR++ N R EC R + P+ V + I S Q TQ
Sbjct: 63 CALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSN 122
Query: 124 GRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMEC 182
GRRP+G+ LI G+D D P ++QT PS Y +A +IG ++S R +LE++ ++
Sbjct: 123 GRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIE 182
Query: 183 NLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQR 242
+ +K ++AL E + + KN+ + ++ +D I + +++ ++ +E+ +
Sbjct: 183 TDDLTIKLVIKALLEVVQS----GGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEE 238
Query: 243 KAQPAQ 248
+ Q
Sbjct: 239 NEKKKQ 244
>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
Length = 256
Score = 134 bits (338), Expect = 6e-32
Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 13/247 (5%)
Query: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 61
++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + +
Sbjct: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
Query: 62 KILHVDNHIGISIA------GLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSK 115
KI +D+H+ ++ A GLTADAR++ N R EC + + P+ V + I +
Sbjct: 63 KICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
Query: 116 TQIPTQRYGRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLER 174
Q TQ GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE+
Sbjct: 123 KQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEK 182
Query: 175 HMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLE 234
+ +E + +E +K ++AL E + + KN+ + I+ ++ ++ +V ++
Sbjct: 183 NYTEDAIASDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVT 238
Query: 235 GLEERPQ 241
+E+ +
Sbjct: 239 EIEKEKE 245
>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
Length = 234
Score = 121 bits (303), Expect = 7e-28
Identities = 71/216 (32%), Positives = 120/216 (55%), Gaps = 6/216 (2%)
Query: 1 MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60
M Y +T +SP G++ QIEYA+ AV G+ +VG+K+ VL K+ +S L +
Sbjct: 1 MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
Query: 61 K--KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQI 118
K+ + HIG+ +G+ D R+L + R+ V+ P+P ++LV + S Q
Sbjct: 61 SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120
Query: 119 PTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSE 178
TQ G RP+GV LLI G+++ P++FQ+ PS YF +A ++G + +T+LE+ +E
Sbjct: 121 YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE 180
Query: 179 FMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGI 214
+E L + + + L+E+ E +T N+ +GI
Sbjct: 181 DLE--LEDAIHTAILTLKESF--EGQMTEDNIEVGI 212
>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
Length = 241
Score = 121 bits (303), Expect = 7e-28
Identities = 74/243 (30%), Positives = 126/243 (51%), Gaps = 15/243 (6%)
Query: 3 RNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQ 60
R++YD V +SP+GR+ Q+EYA+EA+K GS +G+++ L KR S L +
Sbjct: 5 RSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSI 64
Query: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPL-------PVSRLVSLIG 113
+KI+ +D HIG +++GL ADA+ L + R E + F ++ + VS L G
Sbjct: 65 EKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFG 124
Query: 114 SKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLE 173
+ P RP+GV LL G D+ GP +F PS + C A +IG+ S+ A++ L+
Sbjct: 125 EEDADPGAM--SRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQ 182
Query: 174 RHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFL 233
+ M L E +K L L++ + E+ L N+ + V F ++ +++ +
Sbjct: 183 EVYHKSM--TLKEAIKSSLIILKQVM--EEKLNATNIELATVQPGQNFHMFTKEELEEVI 238
Query: 234 EGL 236
+ +
Sbjct: 239 KDI 241
>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
Length = 212
Score = 113 bits (283), Expect = 1e-25
Identities = 69/239 (28%), Positives = 119/239 (49%), Gaps = 41/239 (17%)
Query: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKI 63
++YD +TV+SP G + Q+EYA EAVK+GS VG++
Sbjct: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIR------------------------ 38
Query: 64 LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 123
GLTADAR++ N R EC + + P+ V + I + Q TQ
Sbjct: 39 ------------GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 86
Query: 124 GRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMEC 182
GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE++ +E
Sbjct: 87 GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIA 146
Query: 183 NLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQ 241
+ +E +K ++AL E + + KN+ + I+ ++ ++ +V ++ +E+ +
Sbjct: 147 SDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKE 201
>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 106 bits (264), Expect = 2e-23
Identities = 75/259 (28%), Positives = 133/259 (51%), Gaps = 10/259 (3%)
Query: 5 QYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAH---QK 61
+YD+ T++SP+GR++Q+EYAMEA+ +G+ + +L A +R +L +
Sbjct: 4 RYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSE 63
Query: 62 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 121
KI ++ + S+AG+T+DA +L N +R + P+P +LV+ + Q TQ
Sbjct: 64 KIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQ 123
Query: 122 RYGRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 180
G+RP+GV LL G+D G ++Q+ PS NY +A IG S +A + L++ E
Sbjct: 124 FGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKE-G 182
Query: 181 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFT---IYDDDDVSPFLEGLE 237
E L + ++ L +T+ + L+ + V I + ++ T + +V ++ E
Sbjct: 183 EMTLKSALALAIKVLNKTMDVSK-LSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHE 241
Query: 238 ERPQRKAQPAQPADEPAEK 256
E + KA+ + E EK
Sbjct: 242 EE-EAKAEREKKEKEQKEK 259
>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 106 bits (264), Expect = 2e-23
Identities = 75/259 (28%), Positives = 133/259 (51%), Gaps = 10/259 (3%)
Query: 5 QYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAH---QK 61
+YD+ T++SP+GR++Q+EYAMEA+ +G+ + +L A +R +L +
Sbjct: 4 RYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSE 63
Query: 62 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 121
KI ++ + S+AG+T+DA +L N +R + P+P +LV+ + Q TQ
Sbjct: 64 KIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQ 123
Query: 122 RYGRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 180
G+RP+GV LL G+D G ++Q+ PS NY +A IG S +A + L++ E
Sbjct: 124 FGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKE-G 182
Query: 181 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFT---IYDDDDVSPFLEGLE 237
E L + ++ L +T+ + L+ + V I + ++ T + +V ++ E
Sbjct: 183 EMTLKSALALAIKVLNKTMDVSK-LSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHE 241
Query: 238 ERPQRKAQPAQPADEPAEK 256
E + KA+ + E EK
Sbjct: 242 EE-EAKAEREKKEKEQKEK 259
>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
Length = 246
Score = 104 bits (260), Expect = 7e-23
Identities = 62/239 (25%), Positives = 122/239 (51%), Gaps = 7/239 (2%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSEL--AAHQKK 62
+D +T++SP+GR++Q+EYA +A+ QG T V ++ K AV+V K+ +L ++
Sbjct: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
Query: 63 ILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQR 122
+ + +IG + G+TAD+R R E + ++ + +PV L I +Q+ TQ
Sbjct: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128
Query: 123 YGRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 181
RP G +++ G D + GP +++ P+ Y +A + G + + ++LE+ + + +
Sbjct: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188
Query: 182 CNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVG-KDLEFTIYDDDDVSPFLEGLEER 239
+ V+ + L L D + +G+V ++ +F I + ++ L L ER
Sbjct: 189 WTFEQTVETAITCLSTVLSI--DFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAER 245
>gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
Length = 255
Score = 97.1 bits (240), Expect = 1e-20
Identities = 55/180 (30%), Positives = 91/180 (50%), Gaps = 3/180 (1%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQKKI 63
YD + +SP GR+ Q+EYAM+AV+ S +G++ K V K S+L K++
Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
Query: 64 LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 123
+VD H+G+++AGL ADAR L + R+E + R F +P+ L + T
Sbjct: 68 FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
Query: 124 GRRPYGVGLLIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMEC 182
RP+G ++ Y + G ++ PS + +IG Q+A+T +E+ + M C
Sbjct: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 187
>gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]
Length = 248
Score = 91.3 bits (225), Expect = 8e-19
Identities = 54/179 (30%), Positives = 89/179 (49%), Gaps = 8/179 (4%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQKKI 63
YD + +SP GR+ Q+EYAM+AV+ S +G++ K V K S+L K++
Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
Query: 64 LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 123
+VD H+G+++AGL ADAR L + R+E + R F +P+ L + T
Sbjct: 68 FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
Query: 124 GRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMEC 182
RP+G + + G ++ PS + +IG Q+A+T +E+ + M C
Sbjct: 128 AVRPFGCSV------NDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 180
>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
Length = 190
Score = 68.9 bits (167), Expect = 4e-12
Identities = 54/188 (28%), Positives = 93/188 (49%), Gaps = 7/188 (3%)
Query: 73 SIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGL 132
S+AG+T+DA +L N +R + P+P +LV+ + Q TQ G+RP+GV L
Sbjct: 4 SVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSL 63
Query: 133 LIAGYD-DMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHG 191
L G+D G ++Q+ PS NY +A IG S +A + L++ E E L +
Sbjct: 64 LYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKE-GEMTLKSALALA 122
Query: 192 LRALRETLPAEQDLTTKNVSIGIVGKDLEFT---IYDDDDVSPFLEGLEERPQRKAQPAQ 248
++ L +T+ + L+ + V I + ++ T + +V ++ EE + KA+ +
Sbjct: 123 IKVLNKTMDVSK-LSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEE-EAKAEREK 180
Query: 249 PADEPAEK 256
E EK
Sbjct: 181 KEKEQKEK 188
>gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 48.1 bits (113), Expect = 8e-06
Identities = 34/169 (20%), Positives = 73/169 (43%), Gaps = 38/169 (22%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSELAAHQKKIL 64
+D + ++SP+ +++Q++YA +A+ QG T V ++ K AV+V K +L + +
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRTHLF 152
Query: 65 HVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYG 124
+ + G I G+TAD+R S+ Q +
Sbjct: 153 KMTKNTGRVITGVTADSR-------------------------------SREQRAQYKAA 181
Query: 125 RRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLE 173
Y + ++++GP +++ + Y +A + G + + ++LE
Sbjct: 182 NCKYNI------FEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224
>gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 48.1 bits (113), Expect = 8e-06
Identities = 34/169 (20%), Positives = 73/169 (43%), Gaps = 38/169 (22%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSELAAHQKKIL 64
+D + ++SP+ +++Q++YA +A+ QG T V ++ K AV+V K +L + +
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRTHLF 152
Query: 65 HVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYG 124
+ + G I G+TAD+R S+ Q +
Sbjct: 153 KMTKNTGRVITGVTADSR-------------------------------SREQRAQYKAA 181
Query: 125 RRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLE 173
Y + ++++GP +++ + Y +A + G + + ++LE
Sbjct: 182 NCKYNI------FEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224
>gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 48.1 bits (113), Expect = 8e-06
Identities = 34/169 (20%), Positives = 73/169 (43%), Gaps = 38/169 (22%)
Query: 6 YDNDVTVWSPQGRIHQIEYAMEAVKQGSAT-VGLKSKTHAVLVALKRAQSELAAHQKKIL 64
+D + ++SP+ +++Q++YA +A+ QG T V ++ K AV+V K +L + +
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRTHLF 152
Query: 65 HVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYG 124
+ + G I G+TAD+R S+ Q +
Sbjct: 153 KMTKNTGRVITGVTADSR-------------------------------SREQRAQYKAA 181
Query: 125 RRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLE 173
Y + ++++GP +++ + Y +A + G + + ++LE
Sbjct: 182 NCKYNI------FEELGPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224
>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
Length = 263
Score = 34.7 bits (78), Expect = 0.087
Identities = 32/153 (20%), Positives = 64/153 (41%), Gaps = 7/153 (4%)
Query: 32 GSATVGLKSKTHAVLVALKRAQS-ELAAHQ--KKILHVDNHIGISIAGLTADARLLCNFM 88
G+ T+ K + ++ A RA + A Q KK++ ++ ++ ++AG AD +
Sbjct: 59 GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118
Query: 89 RQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTC 148
++C + V+ L+ + +Y +G +I G+D GP ++
Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVY----QYKGMGLSMGTMICGWDKRGPGLYYVD 174
Query: 149 PSANYFDCRAMSIGARSQSARTYLERHMSEFME 181
N S+G+ S A ++R S +E
Sbjct: 175 SEGNRISGATFSVGSGSVYAYGVMDRGYSYDLE 207
>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
Length = 273
Score = 33.9 bits (76), Expect = 0.15
Identities = 45/192 (23%), Positives = 73/192 (38%), Gaps = 25/192 (13%)
Query: 28 AVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK---KILHVDNHIGISIAGLTADARLL 84
A K G+ GL + +L A RA ++ K KI + I AG+ ADA +
Sbjct: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
Query: 85 CNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHI 144
+ + ++ + P V+ I +T Q + G L++ G D GP +
Sbjct: 95 TRMVASK-MELHALSTGREPRVATVTRILRQTLFRYQGH----VGASLIVGGVDLTGPQL 149
Query: 145 FQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQD 204
+ P +Y ++G+ +A LE M TL A Q
Sbjct: 150 YGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNM-----------------TLEAAQG 192
Query: 205 LTTKNVSIGIVG 216
L + V+ GI+G
Sbjct: 193 LLVEAVTAGILG 204
>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
Length = 277
Score = 33.1 bits (74), Expect = 0.25
Identities = 37/156 (23%), Positives = 60/156 (38%), Gaps = 10/156 (6%)
Query: 30 KQGSATVGLKSKTHAVLVALKRAQSELAAHQK---KILHVDNHIGISIAGLTADARLLCN 86
K G+ G+ K VL A RA + K KI + +I AG AD
Sbjct: 41 KTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTD---- 96
Query: 87 FMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPY-GVGLLIAGYDDMGPHIF 145
M + + S L RL ++ + + + + Y G L++ G D GPH++
Sbjct: 97 -MTTQLISSNLEL-HSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLY 154
Query: 146 QTCPSANYFDCRAMSIGARSQSARTYLERHMSEFME 181
P + +++G+ S +A E ME
Sbjct: 155 SIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME 190
>gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
Length = 1530
Score = 33.1 bits (74), Expect = 0.25
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 177 SEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGL 236
+E NL L H + ALRE +E+ V++ VG+ E D +D P +
Sbjct: 906 NEAAALNLEHL--HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTA 963
Query: 237 EERPQRKAQPAQPADEPAEKADEPM 261
+R + +EPA++ E M
Sbjct: 964 SKREDGSEEAILGGEEPAKERKEVM 988
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 29.6 bits (65), Expect = 2.8
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 10/84 (11%)
Query: 21 QIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGIS--IAGLT 78
+++ +ME + S ++ TH L +A L AH + + H NH+ I+ + +
Sbjct: 540 ELQISMEVNDRAS-----QASTHGNLAVAYQA---LGAHDRALQHYQNHLNIARELRDIQ 591
Query: 79 ADARLLCNFMRQECLDSRFVFDRP 102
++AR L N C +V P
Sbjct: 592 SEARALSNLGNFHCSRGEYVQAAP 615
>gi|7705344 DNA-directed DNA polymerase kappa [Homo sapiens]
Length = 870
Score = 29.6 bits (65), Expect = 2.8
Identities = 38/176 (21%), Positives = 64/176 (36%), Gaps = 20/176 (11%)
Query: 91 ECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPS 150
E D+ + D+P+ V GS + + T Y R +GV + G+ + CP
Sbjct: 116 EMRDNPELKDKPIAV-------GSMSMLSTSNYHARRFGVRAAMPGFIAK-----RLCPQ 163
Query: 151 ANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNV 210
A S+ + L + FM +L+E + + L E +D +
Sbjct: 164 LIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFI 223
Query: 211 SIGI------VGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEP 260
+G GK++ + +SP L EE P P P E+ + P
Sbjct: 224 KMGSSVENDNPGKEVNKLSEHERSISPLL--FEESPSDVQPPGDPFQVNFEEQNNP 277
>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
Length = 1037
Score = 28.9 bits (63), Expect = 4.8
Identities = 48/220 (21%), Positives = 84/220 (38%), Gaps = 28/220 (12%)
Query: 38 LKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRF 97
+K+++ V++ LK SEL A + H L A C F+R E + R
Sbjct: 394 MKTESQRVVLQLKGHVSELEADLAEQQH-----------LRQQAADDCEFLRAELDELRR 442
Query: 98 VFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCR 157
+ R +S I K Q QRY + L+ + D+ +
Sbjct: 443 QREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQV------ 496
Query: 158 AMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPA----EQDLTTKNVSIG 213
+ ++ A+ LER E +E +L + G R +E L +Q+L T +
Sbjct: 497 -----SMARQAQVDLEREKKE-LEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQ 550
Query: 214 IVGKDLEFTIYDDDD-VSPFLEGLEERPQRKAQPAQPADE 252
++ LE + + + + F E +ER + A +E
Sbjct: 551 VLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEE 590
>gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]
Length = 887
Score = 28.9 bits (63), Expect = 4.8
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 7/94 (7%)
Query: 29 VKQGSATV-GLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNF 87
V QGSA + G + ++H LV+L++ Q AAH + + +G+S G A+ L
Sbjct: 689 VPQGSAVLTGPQQQSHQ-LVSLQQLQQPTAAHPPQPGPQGSALGLSTQGQAFPAQQLLKV 747
Query: 88 MRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 121
+P P ++SL+GS Q+P Q
Sbjct: 748 NPTRARSGL----QPQPQPAVLSLLGS-AQVPQQ 776
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 28.5 bits (62), Expect = 6.2
Identities = 18/73 (24%), Positives = 33/73 (45%)
Query: 190 HGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQP 249
+GLR+L P Q L + + G++L DDDD S + L+E +
Sbjct: 1060 NGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNT 1119
Query: 250 ADEPAEKADEPME 262
++ E+ +E ++
Sbjct: 1120 EEDELEEEEEDLQ 1132
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 28.5 bits (62), Expect = 6.2
Identities = 14/31 (45%), Positives = 18/31 (58%), Gaps = 1/31 (3%)
Query: 223 IYDDDDVSPFLEGLEERPQRKAQPAQPADEP 253
IYDD+ +S G +E P+ AQP QP P
Sbjct: 304 IYDDNSLSQDFPG-DESPRPDAQPTQPTPAP 333
>gi|16905522 golgi SNAP receptor complex member 2 isoform A [Homo
sapiens]
Length = 212
Score = 28.5 bits (62), Expect = 6.2
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 7 DNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHV 66
D+D T+ P Q +++ V G + L H +L L+ + L QKKIL +
Sbjct: 113 DSDTTI--PMDESLQFNSSLQKVHNGMDDLILDG--HNILDGLRTQRLTLKGTQKKILDI 168
Query: 67 DNHIGIS 73
N +G+S
Sbjct: 169 ANMLGLS 175
>gi|16905520 golgi SNAP receptor complex member 2 isoform B [Homo
sapiens]
Length = 213
Score = 28.5 bits (62), Expect = 6.2
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 7 DNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHV 66
D+D T+ P Q +++ V G + L H +L L+ + L QKKIL +
Sbjct: 113 DSDTTI--PMDESLQFNSSLQKVHNGMDDLILDG--HNILDGLRTQRLTLKGTQKKILDI 168
Query: 67 DNHIGIS 73
N +G+S
Sbjct: 169 ANMLGLS 175
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,759,900
Number of Sequences: 37866
Number of extensions: 415998
Number of successful extensions: 1246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1199
Number of HSP's gapped (non-prelim): 41
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.