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Search of human proteins with 4505895
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
(514 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 1060 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 139 5e-33
gi|16554627 WD repeat domain 5 [Homo sapiens] 139 5e-33
gi|23199987 WD repeat domain 5B [Homo sapiens] 137 3e-32
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 130 2e-30
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 129 8e-30
gi|32189425 WD repeat domain 69 [Homo sapiens] 128 1e-29
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 125 9e-29
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 125 9e-29
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 125 9e-29
gi|113865883 WD repeat domain 38 [Homo sapiens] 122 6e-28
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 110 3e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 104 2e-22
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 104 2e-22
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 104 2e-22
gi|157266266 WD repeat domain 86 [Homo sapiens] 103 5e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 102 6e-22
gi|26665869 WD repeat domain 51B [Homo sapiens] 102 6e-22
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 101 2e-21
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 101 2e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 100 3e-21
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 100 5e-21
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 100 5e-21
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 100 5e-21
gi|21071067 TBP-associated factor 5 [Homo sapiens] 99 9e-21
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 97 4e-20
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 96 1e-19
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 95 1e-19
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 95 1e-19
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 95 1e-19
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 1060 bits (2742), Expect = 0.0
Identities = 514/514 (100%), Positives = 514/514 (100%)
Query: 1 MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT 60
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
Sbjct: 1 MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT 60
Query: 61 SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE 120
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
Sbjct: 61 SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE 120
Query: 121 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK 180
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
Sbjct: 121 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK 180
Query: 181 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL 240
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
Sbjct: 181 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL 240
Query: 241 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI 300
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
Sbjct: 241 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI 300
Query: 301 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
Sbjct: 301 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
Query: 361 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT 420
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
Sbjct: 361 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT 420
Query: 421 VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA 480
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
Sbjct: 421 VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA 480
Query: 481 EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF 514
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
Sbjct: 481 EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF 514
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 139 bits (351), Expect = 5e-33
Identities = 90/327 (27%), Positives = 159/327 (48%), Gaps = 22/327 (6%)
Query: 174 NSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL 233
+SA +K P P + L ++GH V + P +W + SAD+ IKIW
Sbjct: 21 SSATQSKPTPVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
Query: 234 ASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYG 293
GK + +++GH + V S+ S L S +DK +K WD+ K ++ GH + V+
Sbjct: 75 YDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC 134
Query: 294 LDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTT 353
+ +P +++V+ S D + RIWDV+T + TL H++ V+ V I++ S+D
Sbjct: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 354 IRLWDLVAGKTRVTL-TNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSG 411
R+WD +G+ TL + V V P Y A+ + +K W + G ++ +G
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 412 HN----AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467
H I +V +VSG+++ +++W+ +T Q++ G D + +
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VIS 306
Query: 468 CAFDQSESRLLTA--EADKTIKVYRED 492
A +E+ + +A E DKTIK+++ D
Sbjct: 307 TACHPTENIIASAALENDKTIKLWKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 139 bits (351), Expect = 5e-33
Identities = 90/327 (27%), Positives = 159/327 (48%), Gaps = 22/327 (6%)
Query: 174 NSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL 233
+SA +K P P + L ++GH V + P +W + SAD+ IKIW
Sbjct: 21 SSATQSKPTPVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
Query: 234 ASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYG 293
GK + +++GH + V S+ S L S +DK +K WD+ K ++ GH + V+
Sbjct: 75 YDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC 134
Query: 294 LDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTT 353
+ +P +++V+ S D + RIWDV+T + TL H++ V+ V I++ S+D
Sbjct: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 354 IRLWDLVAGKTRVTL-TNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSG 411
R+WD +G+ TL + V V P Y A+ + +K W + G ++ +G
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 412 HN----AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467
H I +V +VSG+++ +++W+ +T Q++ G D + +
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VIS 306
Query: 468 CAFDQSESRLLTA--EADKTIKVYRED 492
A +E+ + +A E DKTIK+++ D
Sbjct: 307 TACHPTENIIASAALENDKTIKLWKSD 333
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 137 bits (344), Expect = 3e-32
Identities = 89/330 (26%), Positives = 160/330 (48%), Gaps = 16/330 (4%)
Query: 168 ETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRT 227
E+ + K ++ A + +P + L + GH V + P +W + SADR
Sbjct: 5 ESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRL 64
Query: 228 IKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGH 287
I IW GK + +L GH + V S+ S L S +DK +K WD+ K ++ GH
Sbjct: 65 IIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH 124
Query: 288 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT 347
+ V+ + +P +++++ S D T +IW+V+T + TLS H++ V+ V + I++
Sbjct: 125 SNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVS 184
Query: 348 GSHDTTIRLWDLVAGKTRVTLT-NHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSF 405
GS+D R+WD +G+ TL + V V P + + DN +K W + G
Sbjct: 185 GSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC 244
Query: 406 IQNLSGHN----AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDS 461
++ +GH I +V +VSG+++ +++W+ +T Q++ G D
Sbjct: 245 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV 299
Query: 462 ESGIFACAFDQSESRLLTA--EADKTIKVY 489
+ + A +E+ + +A E DKTIK++
Sbjct: 300 ---VISAACHPTENLIASAALENDKTIKLW 326
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 130 bits (328), Expect = 2e-30
Identities = 67/249 (26%), Positives = 114/249 (45%), Gaps = 1/249 (0%)
Query: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI 253
WKL +++ + + + TG D + +W + +SLTGH S V V
Sbjct: 11 WKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR 70
Query: 254 VSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313
++T + + + ++ WDLE K++R GH + + LD HP + + + S+D+ +
Sbjct: 71 LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
Query: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK 373
+WD+R K V GH+ AV +R + + + D T++LWDL AGK H
Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
Query: 374 SVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGAD 432
V V HP Y ASGS D I+ W + + G + ++ N DG +
Sbjct: 191 PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGC 250
Query: 433 NGTMHLWDW 441
++ ++ W
Sbjct: 251 QDSLRVYGW 259
Score = 90.9 bits (224), Expect = 3e-18
Identities = 58/190 (30%), Positives = 86/190 (45%), Gaps = 10/190 (5%)
Query: 302 VLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361
+L T D +W + + +L+GHT+ V +VR E I+ GS +IR+WDL A
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 362 GKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLT 420
K TL HK ++ ++ HP ASGS D NIK W + GH+ + L
Sbjct: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
Query: 421 VNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLT 479
+ DG L S AD+ T+ LWD G P + F +E L +
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP--------VNVVEFHPNEYLLAS 206
Query: 480 AEADKTIKVY 489
+D+TI+ +
Sbjct: 207 GSSDRTIRFW 216
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 129 bits (323), Expect = 8e-30
Identities = 87/323 (26%), Positives = 143/323 (44%), Gaps = 30/323 (9%)
Query: 189 QWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIST 248
+W P +SGH V + P V+ S D TIK+WD +G + +L GH +
Sbjct: 93 EWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
Query: 249 VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSR 308
V+ + L SC D +K WD + + IR HGH V + + P D +V+ SR
Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
Query: 309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL 368
D T ++W+V+T V T +GH V VR I + S+D T+R+W + + + L
Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
Query: 369 TNHKKSVRAVVLHPR-----------HYTFASGSP----------DNIKQWKFPDGSFIQ 407
H+ V + P T SG P IK W G +
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
Query: 408 NLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIF 466
L GH+ + + +S G ++S AD+ T+ +WD++ + ++A E +
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA--------HEHFVT 384
Query: 467 ACAFDQSESRLLTAEADKTIKVY 489
+ F ++ ++T D+T+KV+
Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVW 407
Score = 86.7 bits (213), Expect = 5e-17
Identities = 46/181 (25%), Positives = 82/181 (45%), Gaps = 20/181 (11%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+ +GH WVR + + S D+T+++W +A+ + K L H V + +
Sbjct: 228 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE 287
Query: 258 S--------------------PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLH 297
S P+L S DK +K WD+ + GH + V G+ H
Sbjct: 288 SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH 347
Query: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
+++C+ D T R+WD + K + TL+ H + V ++ P ++TGS D T+++W
Sbjct: 348 SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Query: 358 D 358
+
Sbjct: 408 E 408
Score = 84.0 bits (206), Expect = 3e-16
Identities = 42/126 (33%), Positives = 71/126 (56%), Gaps = 1/126 (0%)
Query: 193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV 252
P Y IS G + +PG + ++GS D+TIK+WD+++G ++L GH + VRGV
Sbjct: 286 PESSYSSISEATGSETKKSGKPG-PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV 344
Query: 253 IVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTA 312
+ + ++ SC +DK ++ WD + + ++ + H V LD H T +VT S D T
Sbjct: 345 LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404
Query: 313 RIWDVR 318
++W+ R
Sbjct: 405 KVWECR 410
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 128 bits (322), Expect = 1e-29
Identities = 90/342 (26%), Positives = 156/342 (45%), Gaps = 57/342 (16%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
L++V+ H+ + +A+ F+TGS DRT K+WD ASG+ +L GH + V ++
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVV--YAIA 141
Query: 256 TRSPY---LFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTA 312
+PY + + DK K W +E K + GH + + L +P ++ T S D+TA
Sbjct: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
Query: 313 RIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHK 372
++WD++ V+TL GH+ + ++ + +IITGS D T+ +WD G+ L H
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
Query: 373 KSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGH-NAIINT---------LTV 421
+ + + +GS D K W +G + L+GH + I+++ T
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 422 NSDGV---------------------------------LVSGADNGTMHLWDWRTGYNFQ 448
++DG L++G+ + T +WD +TG Q
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ 381
Query: 449 RVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490
V G D IF+CAF+ + ++T D T +++R
Sbjct: 382 -----VLEGHTDE---IFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 106 bits (265), Expect = 4e-23
Identities = 61/247 (24%), Positives = 108/247 (43%), Gaps = 2/247 (0%)
Query: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
K Y GH + C++ P + TGS D T K+WD+ +G+ +L GH + + +
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+T + + D V WD + + + GH + + + +++T S D T ++
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
WD V TL+GH + + I T S D T R++ K L H+
Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE 347
Query: 375 VRAVVLHPRHYTFASGSPDNIKQ-WKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGAD 432
+ + +P+ +GS D + W G +Q L GH I + N G ++++G+
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSK 407
Query: 433 NGTMHLW 439
+ T +W
Sbjct: 408 DNTCRIW 414
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 125 bits (314), Expect = 9e-29
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 20/294 (6%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+V+ GH V GN+ V+GS D T+K+W +GK +L GH V R
Sbjct: 256 KVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSS--QMR 312
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
+ S D+ +K W+ E + I +GH S V + LH +V+ SRD+T R+WD+
Sbjct: 313 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDI 370
Query: 318 RTKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
T +H L GH VA VRC Q ++++G++D +++WD TL H V
Sbjct: 371 ETGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427
Query: 377 AVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGT 435
++ H SGS D +I+ W G+ I L+GH ++ + + + D +LVSG + T
Sbjct: 428 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-KDNILVSGNADST 484
Query: 436 MHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+ +WD +TG Q + G +S + F +++ ++T+ D T+K++
Sbjct: 485 VKIWDIKTGQCLQTLQ-----GPNKHQSAVTCLQF--NKNFVITSSDDGTVKLW 531
Score = 123 bits (309), Expect = 3e-28
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 15/254 (5%)
Query: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
K R + GH G V + + ++GS DRT+K+W+ +G+ +L GH STVR + +
Sbjct: 294 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + S D ++ WD+E + + GH++AV + +V+ + D ++
Sbjct: 352 HEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKV 407
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
WD T+ +HTL GHTN V +++ +++GS DT+IR+WD+ G TLT H+
Sbjct: 408 WDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSL 465
Query: 375 VRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG---HNAIINTLTVNSDGVLVSG 430
+ L + SG+ D+ +K W G +Q L G H + + L N + V+ S
Sbjct: 466 TSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS- 522
Query: 431 ADNGTMHLWDWRTG 444
+D+GT+ LWD +TG
Sbjct: 523 SDDGTVKLWDLKTG 536
Score = 108 bits (269), Expect = 2e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
GH VRC+ + + V+GS D T+++WD+ +G+ L GH++ VR V R +
Sbjct: 341 GHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--V 396
Query: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
S D VK WD E + GH + VY L +V+ S D++ R+WDV T
Sbjct: 397 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN 454
Query: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL- 380
+HTL+GH + + + + + +++G+ D+T+++WD+ G+ TL K AV
Sbjct: 455 CIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512
Query: 381 -HPRHYTFASGSPDNIKQWKFPDGSFIQNL-----SGHNAIINTLTV-NSDGVLVSGADN 433
+++ S +K W G FI+NL G ++ + N+ V G+ N
Sbjct: 513 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 572
Query: 434 GT 435
GT
Sbjct: 573 GT 574
Score = 85.9 bits (211), Expect = 8e-17
Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
V+ GH+ VRC+ + + V+G+ D +K+WD + +L GH + V +
Sbjct: 378 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--G 433
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
++ S D ++ WD+E I GH S G++L I LV+ + DST +IWD++
Sbjct: 434 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 491
Query: 319 TKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGK 363
T + TL G + V C Q + +IT S D T++LWDL G+
Sbjct: 492 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 125 bits (314), Expect = 9e-29
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 20/294 (6%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+V+ GH V GN+ V+GS D T+K+W +GK +L GH V R
Sbjct: 374 KVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSS--QMR 430
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
+ S D+ +K W+ E + I +GH S V + LH +V+ SRD+T R+WD+
Sbjct: 431 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDI 488
Query: 318 RTKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
T +H L GH VA VRC Q ++++G++D +++WD TL H V
Sbjct: 489 ETGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
Query: 377 AVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGT 435
++ H SGS D +I+ W G+ I L+GH ++ + + + D +LVSG + T
Sbjct: 546 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-KDNILVSGNADST 602
Query: 436 MHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+ +WD +TG Q + G +S + F +++ ++T+ D T+K++
Sbjct: 603 VKIWDIKTGQCLQTLQ-----GPNKHQSAVTCLQF--NKNFVITSSDDGTVKLW 649
Score = 123 bits (309), Expect = 3e-28
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 15/254 (5%)
Query: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
K R + GH G V + + ++GS DRT+K+W+ +G+ +L GH STVR + +
Sbjct: 412 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + S D ++ WD+E + + GH++AV + +V+ + D ++
Sbjct: 470 HEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKV 525
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
WD T+ +HTL GHTN V +++ +++GS DT+IR+WD+ G TLT H+
Sbjct: 526 WDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
Query: 375 VRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG---HNAIINTLTVNSDGVLVSG 430
+ L + SG+ D+ +K W G +Q L G H + + L N + V+ S
Sbjct: 584 TSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS- 640
Query: 431 ADNGTMHLWDWRTG 444
+D+GT+ LWD +TG
Sbjct: 641 SDDGTVKLWDLKTG 654
Score = 108 bits (269), Expect = 2e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
GH VRC+ + + V+GS D T+++WD+ +G+ L GH++ VR V R +
Sbjct: 459 GHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--V 514
Query: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
S D VK WD E + GH + VY L +V+ S D++ R+WDV T
Sbjct: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN 572
Query: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL- 380
+HTL+GH + + + + + +++G+ D+T+++WD+ G+ TL K AV
Sbjct: 573 CIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
Query: 381 -HPRHYTFASGSPDNIKQWKFPDGSFIQNL-----SGHNAIINTLTV-NSDGVLVSGADN 433
+++ S +K W G FI+NL G ++ + N+ V G+ N
Sbjct: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
Query: 434 GT 435
GT
Sbjct: 691 GT 692
Score = 85.9 bits (211), Expect = 8e-17
Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
V+ GH+ VRC+ + + V+G+ D +K+WD + +L GH + V +
Sbjct: 496 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--G 551
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
++ S D ++ WD+E I GH S G++L I LV+ + DST +IWD++
Sbjct: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 609
Query: 319 TKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGK 363
T + TL G + V C Q + +IT S D T++LWDL G+
Sbjct: 610 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 125 bits (314), Expect = 9e-29
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 20/294 (6%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+V+ GH V GN+ V+GS D T+K+W +GK +L GH V R
Sbjct: 294 KVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSS--QMR 350
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
+ S D+ +K W+ E + I +GH S V + LH +V+ SRD+T R+WD+
Sbjct: 351 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDI 408
Query: 318 RTKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
T +H L GH VA VRC Q ++++G++D +++WD TL H V
Sbjct: 409 ETGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465
Query: 377 AVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGT 435
++ H SGS D +I+ W G+ I L+GH ++ + + + D +LVSG + T
Sbjct: 466 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-KDNILVSGNADST 522
Query: 436 MHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+ +WD +TG Q + G +S + F +++ ++T+ D T+K++
Sbjct: 523 VKIWDIKTGQCLQTLQ-----GPNKHQSAVTCLQF--NKNFVITSSDDGTVKLW 569
Score = 123 bits (309), Expect = 3e-28
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 15/254 (5%)
Query: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
K R + GH G V + + ++GS DRT+K+W+ +G+ +L GH STVR + +
Sbjct: 332 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + S D ++ WD+E + + GH++AV + +V+ + D ++
Sbjct: 390 HEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKV 445
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
WD T+ +HTL GHTN V +++ +++GS DT+IR+WD+ G TLT H+
Sbjct: 446 WDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSL 503
Query: 375 VRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG---HNAIINTLTVNSDGVLVSG 430
+ L + SG+ D+ +K W G +Q L G H + + L N + V+ S
Sbjct: 504 TSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS- 560
Query: 431 ADNGTMHLWDWRTG 444
+D+GT+ LWD +TG
Sbjct: 561 SDDGTVKLWDLKTG 574
Score = 108 bits (269), Expect = 2e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
GH VRC+ + + V+GS D T+++WD+ +G+ L GH++ VR V R +
Sbjct: 379 GHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--V 434
Query: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
S D VK WD E + GH + VY L +V+ S D++ R+WDV T
Sbjct: 435 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN 492
Query: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL- 380
+HTL+GH + + + + + +++G+ D+T+++WD+ G+ TL K AV
Sbjct: 493 CIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550
Query: 381 -HPRHYTFASGSPDNIKQWKFPDGSFIQNL-----SGHNAIINTLTV-NSDGVLVSGADN 433
+++ S +K W G FI+NL G ++ + N+ V G+ N
Sbjct: 551 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 610
Query: 434 GT 435
GT
Sbjct: 611 GT 612
Score = 85.9 bits (211), Expect = 8e-17
Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
V+ GH+ VRC+ + + V+G+ D +K+WD + +L GH + V +
Sbjct: 416 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--G 471
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
++ S D ++ WD+E I GH S G++L I LV+ + DST +IWD++
Sbjct: 472 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 529
Query: 319 TKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGK 363
T + TL G + V C Q + +IT S D T++LWDL G+
Sbjct: 530 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 575
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 122 bits (307), Expect = 6e-28
Identities = 79/241 (32%), Positives = 117/241 (48%), Gaps = 6/241 (2%)
Query: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259
+ GH G V+ P F + S D T+++WD+A K L GH +V V S S
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
Query: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR- 318
L S G DK+V WD++ +++R GH ++ D PT++ L T S DST IWD+R
Sbjct: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
Query: 319 -TKASVH-TLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
T A H L GH+ ++ + C +A + +GS D TI +W + L H V+
Sbjct: 179 VTPAVSHQALEGHSANISCL-CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK 237
Query: 377 AVVLHPRHYTFAS-GSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNG 434
++ P AS G +K W G ++ L G + +T DG +LVSGA +
Sbjct: 238 SIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
Query: 435 T 435
T
Sbjct: 298 T 298
Score = 95.1 bits (235), Expect = 1e-19
Identities = 77/288 (26%), Positives = 120/288 (41%), Gaps = 14/288 (4%)
Query: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
H G V A P Q +TGS D + W+ SG+L L GH V+ S
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS 322
S D V+ WD+ K +R GH +V + P L + D +WDV++
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL---VAGKTRVTLTNHKKSVRAVV 379
+ L GH +++ + + TGS D+T+ +WDL + L H ++ + +
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCL 198
Query: 380 LHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTM-H 437
+ ASGS D I WK S + L GH + ++ + D + ++ A M
Sbjct: 199 CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Query: 438 LWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKT 485
+WD TG + + G LD CAF L++ AD+T
Sbjct: 259 VWDCNTGKCLETL-----KGVLDV---AHTCAFTPDGKILVSGAADQT 298
Score = 79.7 bits (195), Expect = 6e-15
Identities = 60/215 (27%), Positives = 90/215 (41%), Gaps = 14/215 (6%)
Query: 281 IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQA 340
++ + H V P +L+T S D W+ R+ + L GHT V R
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 341 AEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWK 399
+ S D T+RLWD+ K L H++SV V P ASG D + W
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 400 FPDGSFIQNLSGHNAIINTL----TVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455
G ++ L GH I + TVN L +G+ + T+H+WD R V AV
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVN---CLATGSWDSTVHIWDLR------MVTPAVS 184
Query: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490
+L+ S +C + L + DKTI +++
Sbjct: 185 HQALEGHSANISCLCYSASGLLASGSWDKTIHIWK 219
Score = 70.5 bits (171), Expect = 4e-12
Identities = 50/206 (24%), Positives = 83/206 (40%), Gaps = 4/206 (1%)
Query: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
K RV+ GH V ++ P ++ +G D+ + +WD+ SG++ L GH +++
Sbjct: 96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF 155
Query: 255 STRSPYLFSCGEDKQVKCWDLE-YNKVIRH--YHGHLSAVYGLDLHPTIDVLVTCSRDST 311
S L + D V WDL + H GH SA + +L + S D T
Sbjct: 156 SPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH-SANISCLCYSASGLLASGSWDKT 214
Query: 312 ARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNH 371
IW T + + L GH V ++ E + + + +++WD GK TL
Sbjct: 215 IHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGV 274
Query: 372 KKSVRAVVLHPRHYTFASGSPDNIKQ 397
P SG+ D ++
Sbjct: 275 LDVAHTCAFTPDGKILVSGAADQTRR 300
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 110 bits (275), Expect = 3e-24
Identities = 68/233 (29%), Positives = 110/233 (47%), Gaps = 3/233 (1%)
Query: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 269
++++P + + +AD ++K+W L S + + GH V V+ +L + D+
Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRS 346
Query: 270 VKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGH 329
+ WDLE + I H GH VY + H + T D+ R+WD+RT + L GH
Sbjct: 347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406
Query: 330 TNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTF-A 388
+ + I TGS D T ++WDL + T+ H+ V V P H F
Sbjct: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLL 466
Query: 389 SGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGAD-NGTMHLW 439
+G+ DN K W P S ++ L+GH + L ++SDG L++ + T LW
Sbjct: 467 TGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 85.9 bits (211), Expect = 8e-17
Identities = 54/201 (26%), Positives = 89/201 (44%), Gaps = 2/201 (0%)
Query: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259
I GH V + P ++ T DR+ ++WDL + + L GH V +
Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
Query: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319
+ G D + WDL + I GHL +YG++ P + T S D+T ++WD+R
Sbjct: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ 438
Query: 320 KASVHTLSGHTNAVATVRCQAAEPQ-IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378
+ V+T+ H N V V+ + ++TG++D T ++W TL H+ V +
Sbjct: 439 RRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGL 498
Query: 379 VLHPRHYTFASGSPD-NIKQW 398
+ A+ S D K W
Sbjct: 499 DISSDGQLIATCSYDRTFKLW 519
Score = 49.7 bits (117), Expect = 6e-06
Identities = 43/202 (21%), Positives = 77/202 (38%), Gaps = 18/202 (8%)
Query: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV--------ATVRCQAAEPQIITGS 349
P +L T ++W V +HTL GH V +TV + + + +
Sbjct: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300
Query: 350 HDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQN 408
D +++LW L + + + H V V+ HP + D + + W I +
Sbjct: 301 ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360
Query: 409 LSGHNAIINTLTVNSDGVLV-SGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467
GH+ + + + DG L +G + +WD RTG + ++ I+
Sbjct: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE--------IYG 412
Query: 468 CAFDQSESRLLTAEADKTIKVY 489
F + + T D T KV+
Sbjct: 413 INFSPNGYHIATGSGDNTCKVW 434
Score = 39.7 bits (91), Expect = 0.007
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 3/79 (3%)
Query: 200 ISGHLGWVRCIAVEP--GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
I H V + EP GN + +TG+ D T KIW +L GH V G+ +S+
Sbjct: 445 IPAHQNLVTGVKFEPIHGN-FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSD 503
Query: 258 SPYLFSCGEDKQVKCWDLE 276
+ +C D+ K W E
Sbjct: 504 GQLIATCSYDRTFKLWMAE 522
Score = 35.8 bits (81), Expect = 0.096
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 191 HPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIW 231
HP W + ++GH G V + + Q T S DRT K+W
Sbjct: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 104 bits (259), Expect = 2e-22
Identities = 63/202 (31%), Positives = 93/202 (46%), Gaps = 1/202 (0%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
V H VR + Q FVT S D+T+K+W K SL+ HI+ VR S
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
+ S +DK VK WD + + Y H V +D HP+ + D+T ++WDVR
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 319 TKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378
T + H+ AV + + +IT S D+T+++ DL+ G+ TL H+ V
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
Query: 379 VLHPRHYTFAS-GSPDNIKQWK 399
FAS GS + + WK
Sbjct: 240 AFSRTGEYFASGGSDEQVMVWK 261
Score = 94.4 bits (233), Expect = 2e-19
Identities = 62/254 (24%), Positives = 102/254 (40%), Gaps = 5/254 (1%)
Query: 190 WH--PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIS 247
WH P + YR +GH V C+ P +GS D+T++IW H +
Sbjct: 8 WHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA 66
Query: 248 TVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCS 307
TVR V + + +DK VK W K + H++ V P ++V+ S
Sbjct: 67 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 126
Query: 308 RDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVT 367
D T ++WD ++ VH+ H V V + I D T+++WD+ +
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186
Query: 368 LTNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG- 425
H +V + HP +Y + S +K +G + L GH T+ + G
Sbjct: 187 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 246
Query: 426 VLVSGADNGTMHLW 439
SG + + +W
Sbjct: 247 YFASGGSDEQVMVW 260
Score = 79.7 bits (195), Expect = 6e-15
Identities = 63/273 (23%), Positives = 107/273 (39%), Gaps = 16/273 (5%)
Query: 225 DRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHY 284
D + +W + TGH V V S L S DK V+ W +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 285 HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ 344
H + V + VT S D T ++W + + +LS H N VRC P
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN---WVRCAKFSPD 118
Query: 345 ---IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKF 400
I++ S D T++LWD + + + H V V HP A+ DN +K W
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 401 PDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSL 459
+Q+ H+A +N L+ + G L++ + + T+ + D G +H P +
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT- 237
Query: 460 DSESGIFACAFDQSESRLLTAEADKTIKVYRED 492
AF ++ + +D+ + V++ +
Sbjct: 238 -------TVAFSRTGEYFASGGSDEQVMVWKSN 263
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
H V ++ P + +T S+D T+KI DL G+L +L GH V S Y
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 249
Query: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAV 291
S G D+QV W ++ V HG ++ V
Sbjct: 250 SGGSDEQVMVWKSNFDIV---DHGEVTKV 275
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 104 bits (259), Expect = 2e-22
Identities = 63/202 (31%), Positives = 93/202 (46%), Gaps = 1/202 (0%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
V H VR + Q FVT S D+T+K+W K SL+ HI+ VR S
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
+ S +DK VK WD + + Y H V +D HP+ + D+T ++WDVR
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 319 TKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378
T + H+ AV + + +IT S D+T+++ DL+ G+ TL H+ V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 379 VLHPRHYTFAS-GSPDNIKQWK 399
FAS GS + + WK
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWK 299
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/302 (23%), Positives = 118/302 (39%), Gaps = 16/302 (5%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
L R GH V C+ + +GS D + +W + TGH V V S
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 256 TRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315
L S DK V+ W + H + V + VT S D T ++W
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 316 DVRTKASVHTLSGHTNAVATVRCQAAEPQ---IITGSHDTTIRLWDLVAGKTRVTLTNHK 372
+ + +LS H N VRC P I++ S D T++LWD + + + H
Sbjct: 131 ATHRQKFLFSLSQHIN---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
Query: 373 KSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSG 430
V V HP A+ DN +K W +Q+ H+A +N L+ + G L++
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 247
Query: 431 ADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490
+ + T+ + D G +H P + AF ++ + +D+ + V++
Sbjct: 248 SSDSTLKILDLMEGRLLYTLHGHQGPAT--------TVAFSRTGEYFASGGSDEQVMVWK 299
Query: 491 ED 492
+
Sbjct: 300 SN 301
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
H V ++ P + +T S+D T+KI DL G+L +L GH V S Y
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 287
Query: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAV 291
S G D+QV W ++ V HG ++ V
Sbjct: 288 SGGSDEQVMVWKSNFDIV---DHGEVTKV 313
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 104 bits (259), Expect = 2e-22
Identities = 63/202 (31%), Positives = 93/202 (46%), Gaps = 1/202 (0%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
V H VR + Q FVT S D+T+K+W K SL+ HI+ VR S
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
+ S +DK VK WD + + Y H V +D HP+ + D+T ++WDVR
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 319 TKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378
T + H+ AV + + +IT S D+T+++ DL+ G+ TL H+ V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 379 VLHPRHYTFAS-GSPDNIKQWK 399
FAS GS + + WK
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWK 299
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/302 (23%), Positives = 118/302 (39%), Gaps = 16/302 (5%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
L R GH V C+ + +GS D + +W + TGH V V S
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 256 TRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315
L S DK V+ W + H + V + VT S D T ++W
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 316 DVRTKASVHTLSGHTNAVATVRCQAAEPQ---IITGSHDTTIRLWDLVAGKTRVTLTNHK 372
+ + +LS H N VRC P I++ S D T++LWD + + + H
Sbjct: 131 ATHRQKFLFSLSQHIN---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
Query: 373 KSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSG 430
V V HP A+ DN +K W +Q+ H+A +N L+ + G L++
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 247
Query: 431 ADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490
+ + T+ + D G +H P + AF ++ + +D+ + V++
Sbjct: 248 SSDSTLKILDLMEGRLLYTLHGHQGPAT--------TVAFSRTGEYFASGGSDEQVMVWK 299
Query: 491 ED 492
+
Sbjct: 300 SN 301
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
H V ++ P + +T S+D T+KI DL G+L +L GH V S Y
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 287
Query: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAV 291
S G D+QV W ++ V HG ++ V
Sbjct: 288 SGGSDEQVMVWKSNFDIV---DHGEVTKV 313
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 103 bits (256), Expect = 5e-22
Identities = 74/261 (28%), Positives = 120/261 (45%), Gaps = 22/261 (8%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
++ GH +V +E ++ T SAD TI+ WD+ +G+ GH S V ++V+
Sbjct: 52 LLQGHESYVTFCQLE--DEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ 109
Query: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV--------------LV 304
LFS D+ + W ++ ++ R + GH + V L D+ LV
Sbjct: 110 --LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLV 167
Query: 305 TCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364
T S D TA++W V + TL GHT AV + TGS D TIR WD+++G+
Sbjct: 168 TGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ 227
Query: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNS 423
H+ SV + L R SGS D +K W G ++ + H ++ L ++
Sbjct: 228 LRVFREHRGSVICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
Query: 424 DGVLVSGADNGTMHLWDWRTG 444
G L +G+ + +D ++G
Sbjct: 286 -GTLFTGSGDACARAFDAQSG 305
Score = 98.6 bits (244), Expect = 1e-20
Identities = 71/262 (27%), Positives = 113/262 (43%), Gaps = 20/262 (7%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
RV + H G + +++ P Q +TGS D T ++W A G+ L GH S V
Sbjct: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TFCQLE 66
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
F+C D ++ WD+ + ++ Y GH S V + + + L + S D TAR+W V
Sbjct: 67 DEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARVWSV 124
Query: 318 RTKASVHTLSGHTNAVATVRCQ--------------AAEPQIITGSHDTTIRLWDLVAGK 363
GH N V T+ AA ++TGS D T ++W + +G
Sbjct: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
Query: 364 TRVTLTNHKKSVRAVVLH-PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVN 422
TL H +V +VL P H F + I+ W G ++ H + L +
Sbjct: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL- 243
Query: 423 SDGVLVSGADNGTMHLWDWRTG 444
+ ++ SG+ + T+ W TG
Sbjct: 244 VNRLVYSGSADRTVKCWLADTG 265
Score = 77.4 bits (189), Expect = 3e-14
Identities = 48/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%)
Query: 197 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256
++ + GH G V C+ ++ TGS D TI+ WD+ SG+ H +V + +
Sbjct: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLEL 243
Query: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
+ ++S D+ VKCW + + +R + H V L H L T S D+ AR +D
Sbjct: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFD 301
Query: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDL 359
++ GHT + C Q++ T SHD +RLWD+
Sbjct: 302 AQSGELRRVFRGHT---FIINCIQVHGQVLYTASHDGALRLWDV 342
Score = 56.6 bits (135), Expect = 5e-08
Identities = 38/121 (31%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
RV H G V C+ E N+ +GSADRT+K W +G+ + T H V +
Sbjct: 229 RVFREHRGSVICL--ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL--KYH 284
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
+ LF+ D + +D + ++ R + GH + + +H VL T S D R+WDV
Sbjct: 285 AGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHDGALRLWDV 342
Query: 318 R 318
R
Sbjct: 343 R 343
Score = 46.6 bits (109), Expect = 5e-05
Identities = 43/180 (23%), Positives = 71/180 (39%), Gaps = 16/180 (8%)
Query: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 380
+++ + H + + +++TGS D T RLW G+ L H+ V L
Sbjct: 6 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
Query: 381 HPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW- 439
F + I++W G +Q GH +I+N + V ++ + S D T +W
Sbjct: 66 ED-EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDR-TARVWS 123
Query: 440 --------DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLL-TAEADKTIKVYR 490
++R N A P L S CA + + LL T D T KV++
Sbjct: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPST----PCAEEAAAGGLLVTGSTDGTAKVWQ 179
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 102 bits (255), Expect = 6e-22
Identities = 71/268 (26%), Positives = 105/268 (39%), Gaps = 34/268 (12%)
Query: 212 VEPGNQWFVTGSADRTIKIWDLASGKLKLS------------------------------ 241
+ P ++ G + IK+W L S KLK
Sbjct: 276 ISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEM 335
Query: 242 --LTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPT 299
L GH V S L SC ED ++ WDL Y GH V+ LD+ P
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
Query: 300 IDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359
+ S D TAR+W + +GH V V+ + TGS D T+RLW
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
Query: 360 VAGKTRVTLTNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINT 418
G + T H+ V ++ P Y ++G +K W G+ + L GH I +
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
Query: 419 LTVNSD-GVLVSGADNGTMHLWDWRTGY 445
LT + D G++ S + + ++ +WD R Y
Sbjct: 516 LTFSPDSGLIASASMDNSVRVWDIRNTY 543
Score = 94.0 bits (232), Expect = 3e-19
Identities = 55/202 (27%), Positives = 89/202 (44%), Gaps = 1/202 (0%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+++ GH G V + ++ S D +I+ WDL S + GH V + +S
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
S Y S D+ + W + +R Y GHL+ V + HP + L T S D T R+W
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
Query: 318 RTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRA 377
+ SV +GH V ++ + + D ++LWDL +G L H ++ +
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
Query: 378 VVLHPRHYTFASGSPDN-IKQW 398
+ P AS S DN ++ W
Sbjct: 516 LTFSPDSGLIASASMDNSVRVW 537
Score = 92.4 bits (228), Expect = 9e-19
Identities = 46/162 (28%), Positives = 76/162 (46%), Gaps = 11/162 (6%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
R+ +GHL V C+ P + + TGS D+T+++W G TGH V + S
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN 479
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
YL S GED+++K WDL + + GH + L P ++ + S D++ R+WD+
Sbjct: 480 GKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Query: 318 R-----------TKASVHTLSGHTNAVATVRCQAAEPQIITG 348
R + V +G + V +V+ A ++TG
Sbjct: 540 RNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
Score = 77.0 bits (188), Expect = 4e-14
Identities = 42/158 (26%), Positives = 70/158 (44%)
Query: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
GH V + + P + +F +GS DRT ++W GH++ V V S YL
Sbjct: 382 GHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL 441
Query: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
+ DK V+ W + +R + GH V L P L + D ++WD+ +
Sbjct: 442 ATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT 501
Query: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359
L GHT+ + ++ I + S D ++R+WD+
Sbjct: 502 LYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 31.6 bits (70), Expect = 1.8
Identities = 15/66 (22%), Positives = 28/66 (42%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
LY+ + GH + + P + + S D ++++WD+ + G S + GV
Sbjct: 502 LYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561
Query: 256 TRSPYL 261
S L
Sbjct: 562 QMSNVL 567
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 102 bits (255), Expect = 6e-22
Identities = 54/169 (31%), Positives = 81/169 (47%), Gaps = 5/169 (2%)
Query: 194 WKLYRV-----ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIST 248
W +YR + H WVRC P + V+ S D+TIKIWD + + + + +
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 249 VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSR 308
V + + S G D+ VK WD+ NK+++HY H V + HP+ + L+T S
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
D T +I D+ ++TL GHT V TV +G DT + LW
Sbjct: 249 DGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 94.0 bits (232), Expect = 3e-19
Identities = 62/252 (24%), Positives = 101/252 (40%), Gaps = 10/252 (3%)
Query: 143 PSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWK-LYRVIS 201
P YR+ G D +V + + L+A + W P + +
Sbjct: 49 PHARAYRYVGHKD---------VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK 99
Query: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
H VR + Q+ T S D++IK+W + + SL H VR S +
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLI 159
Query: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
SC EDK +K WD + + ++ + +D +P+ + + D T ++WDVR
Sbjct: 160 VSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNK 219
Query: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH 381
+ H+ V + + +IT S D T+++ DL+ G+ TL H V V
Sbjct: 220 LLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS 279
Query: 382 PRHYTFASGSPD 393
FASG D
Sbjct: 280 KGGELFASGGAD 291
Score = 86.7 bits (213), Expect = 5e-17
Identities = 70/324 (21%), Positives = 124/324 (38%), Gaps = 19/324 (5%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
L R GH + + + P + T S D + +W+ GH V V S
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 256 TRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315
L S D+ V+ W + + H + V +D L T S D + ++W
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 316 DVRTKASVHTLSGHTNAVATVRCQAAEPQ---IITGSHDTTIRLWDLVAGKTRVTLTNHK 372
+ + +++L HT+ VRC P I++ S D TI++WD + ++
Sbjct: 130 SMYRQRFLYSLYRHTH---WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSV 186
Query: 373 KSVRAVVLHPRHYTFAS-GSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSG 430
V +P AS GS +K W +Q+ H+ +N ++ + G L++
Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
Query: 431 ADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490
+ +GT+ + D G + P +F +F + + AD + ++R
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGP--------VFTVSFSKGGELFASGGADTQVLLWR 298
Query: 491 EDDTATEETHPVSWKPEIIKRKRF 514
T +E H +KR F
Sbjct: 299 ---TNFDELHCKGLTKRNLKRLHF 319
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/86 (34%), Positives = 42/86 (48%)
Query: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
KL + H G V CI+ P + +T S+D T+KI DL G+L +L GH V V
Sbjct: 219 KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSF 278
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKV 280
S S G D QV W ++++
Sbjct: 279 SKGGELFASGGADTQVLLWRTNFDEL 304
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 101 bits (251), Expect = 2e-21
Identities = 79/279 (28%), Positives = 134/279 (48%), Gaps = 16/279 (5%)
Query: 216 NQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
+Q V+G D TIKIWD + + K LTGH +V + R + + D V+ WD+
Sbjct: 277 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDV 334
Query: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNA 332
+++ H AV L L ++VTCS+D + +WD+ + + L GH A
Sbjct: 335 NTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392
Query: 333 VATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSP 392
V V + I++ S D TI++W+ + TL HK+ + L R SGS
Sbjct: 393 VNVV--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSS 448
Query: 393 DN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVH 451
DN I+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + +
Sbjct: 449 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLVAALDPRAPA 507
Query: 452 AAVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
+ +L SG +F FD E +++++ D TI ++
Sbjct: 508 GTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIW 544
Score = 100 bits (248), Expect = 4e-21
Identities = 71/257 (27%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
R+++GH G V C+ + + +TGS+D T+++WD+ +G++ +L H V + +
Sbjct: 301 RILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFN 356
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 357 NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 414
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
W+ T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 415 WNTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 472
Query: 375 VRAVVLHPRHYTFASGSPD-NIKQW--------KFPDGSF-IQNLSGHNAIINTLTVNSD 424
VR + + SG+ D IK W + P G+ ++ L H+ + L + +
Sbjct: 473 VRCIRFDNKR--IVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD-E 529
Query: 425 GVLVSGADNGTMHLWDW 441
+VS + + T+ +WD+
Sbjct: 530 FQIVSSSHDDTILIWDF 546
Score = 66.6 bits (161), Expect = 5e-11
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
L RV+ GH V + + +++ V+ S DRTIK+W+ ++ + +L GH RG+ +
Sbjct: 382 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGH---KRGIACL 436
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 494
Query: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
WD+ R A + TL H+ V R Q E QI++ SHD TI +WD +
Sbjct: 495 WDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 547
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 26/194 (13%)
Query: 299 TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
TI+ C R S RI H S + V + Q + +I++G D TI++WD
Sbjct: 245 TIESNWRCGRHSLQRI---------HCRSETSKGVYCL--QYDDQKIVSGLRDNTIKIWD 293
Query: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIIN 417
+ + LT H SV + R +GS D+ ++ W G + L H +
Sbjct: 294 KNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVL 351
Query: 418 TLTVNSDGVLVSGADNGTMHLWDWR--TGYNFQRVHAAVQPGSLDSESGIFACAFDQSES 475
L N +G++V+ + + ++ +WD T +RV + + + FD +
Sbjct: 352 HLRFN-NGMMVTCSKDRSIAVWDMASPTDITLRRV-------LVGHRAAVNVVDFD--DK 401
Query: 476 RLLTAEADKTIKVY 489
+++A D+TIKV+
Sbjct: 402 YIVSASGDRTIKVW 415
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 101 bits (251), Expect = 2e-21
Identities = 79/279 (28%), Positives = 134/279 (48%), Gaps = 16/279 (5%)
Query: 216 NQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
+Q V+G D TIKIWD + + K LTGH +V + R + + D V+ WD+
Sbjct: 313 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDV 370
Query: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNA 332
+++ H AV L L ++VTCS+D + +WD+ + + L GH A
Sbjct: 371 NTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428
Query: 333 VATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSP 392
V V + I++ S D TI++W+ + TL HK+ + L R SGS
Sbjct: 429 VNVV--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSS 484
Query: 393 DN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVH 451
DN I+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + +
Sbjct: 485 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLVAALDPRAPA 543
Query: 452 AAVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
+ +L SG +F FD E +++++ D TI ++
Sbjct: 544 GTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIW 580
Score = 100 bits (248), Expect = 4e-21
Identities = 71/257 (27%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
R+++GH G V C+ + + +TGS+D T+++WD+ +G++ +L H V + +
Sbjct: 337 RILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFN 392
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 393 NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 450
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
W+ T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 451 WNTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 508
Query: 375 VRAVVLHPRHYTFASGSPD-NIKQW--------KFPDGSF-IQNLSGHNAIINTLTVNSD 424
VR + + SG+ D IK W + P G+ ++ L H+ + L + +
Sbjct: 509 VRCIRFDNKR--IVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD-E 565
Query: 425 GVLVSGADNGTMHLWDW 441
+VS + + T+ +WD+
Sbjct: 566 FQIVSSSHDDTILIWDF 582
Score = 66.6 bits (161), Expect = 5e-11
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
L RV+ GH V + + +++ V+ S DRTIK+W+ ++ + +L GH RG+ +
Sbjct: 418 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGH---KRGIACL 472
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 530
Query: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
WD+ R A + TL H+ V R Q E QI++ SHD TI +WD +
Sbjct: 531 WDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 583
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 26/194 (13%)
Query: 299 TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
TI+ C R S RI H S + V + Q + +I++G D TI++WD
Sbjct: 281 TIESNWRCGRHSLQRI---------HCRSETSKGVYCL--QYDDQKIVSGLRDNTIKIWD 329
Query: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIIN 417
+ + LT H SV + R +GS D+ ++ W G + L H +
Sbjct: 330 KNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVL 387
Query: 418 TLTVNSDGVLVSGADNGTMHLWDWR--TGYNFQRVHAAVQPGSLDSESGIFACAFDQSES 475
L N +G++V+ + + ++ +WD T +RV + + + FD +
Sbjct: 388 HLRFN-NGMMVTCSKDRSIAVWDMASPTDITLRRV-------LVGHRAAVNVVDFD--DK 437
Query: 476 RLLTAEADKTIKVY 489
+++A D+TIKV+
Sbjct: 438 YIVSASGDRTIKVW 451
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 100 bits (249), Expect = 3e-21
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 9/284 (3%)
Query: 170 GNTKNSALMAKKAPT----MPKPQWHPP---WKLYRVISGHLGWVRCIAVEPGNQWFVTG 222
GNTK+S P + K P +KL + H V C++++P V+
Sbjct: 311 GNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSC 370
Query: 223 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR 282
DR K+ L + L+ GH + L + D VK WDL I
Sbjct: 371 GEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCIL 430
Query: 283 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE 342
+ GH AV+ H + + + S D T++IWDV ++ TL GHT++V ++
Sbjct: 431 TFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS 490
Query: 343 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNI-KQWKFP 401
++T S D T+ +WD G +L H S+ + PR + AS + K W F
Sbjct: 491 NTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
Query: 402 DGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTG 444
I ++ + N + +S G VL + NG +HL D ++G
Sbjct: 551 KLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSG 594
Score = 63.5 bits (153), Expect = 4e-10
Identities = 44/166 (26%), Positives = 67/166 (40%), Gaps = 21/166 (12%)
Query: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
GH V I P + +T SAD+T+ IWD +G + SL GH+ ++ I R +
Sbjct: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
Query: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID----------VLVTCSRDST 311
SC K WD L + +D+ P+ VL S +
Sbjct: 536 ASCDACGVTKLWDFR----------KLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGV 585
Query: 312 ARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
+ D+++ +H L GH N TV + +G D T+R W
Sbjct: 586 IHLLDLKS-GEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 42.7 bits (99), Expect = 8e-04
Identities = 52/203 (25%), Positives = 88/203 (43%), Gaps = 20/203 (9%)
Query: 292 YGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHD 351
+ +D+ P ++ V+ S A+ +D + K + H V+ V Q + +++ D
Sbjct: 318 FPIDMQPNPNLNVSKESLSPAK-FDYKLK---NIFRLHELPVSCVSMQPHKDILVSCGED 373
Query: 352 TTIRLWDLVA-GKTRVTLTN--HKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQ 407
RLW ++ K V LT H + HP A+ S D +K W G I
Sbjct: 374 ---RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCIL 430
Query: 408 NLSGHNAIINTLTVNSDGVLVSGAD-NGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIF 466
GH+ + + T +S G V+ + + T +WD N +R + G DS + I
Sbjct: 431 TFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD----VNSERCRCTLY-GHTDSVNSIE 485
Query: 467 ACAFDQSESRLLTAEADKTIKVY 489
F + LLT+ ADKT+ ++
Sbjct: 486 FFPFSNT---LLTSSADKTLSIW 505
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 99.8 bits (247), Expect = 5e-21
Identities = 77/275 (28%), Positives = 133/275 (48%), Gaps = 16/275 (5%)
Query: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279
++G D +IKIWD S + LTGH +V + R + + D V+ WD+ +
Sbjct: 254 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGE 311
Query: 280 VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNAVATV 336
V+ H AV L L + ++VTCS+D + +WD+ + + L GH AV V
Sbjct: 312 VLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 369
Query: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395
+ I++ S D TI++W + TL HK+ + L R SGS DN I
Sbjct: 370 --DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTI 425
Query: 396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455
+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + + + + +
Sbjct: 426 RLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLQAALDPRAPASTLC 484
Query: 456 PGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
+L SG +F FD E +++++ D TI ++
Sbjct: 485 LRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIW 517
Score = 97.1 bits (240), Expect = 4e-20
Identities = 71/257 (27%), Positives = 123/257 (47%), Gaps = 24/257 (9%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+V++GH G V C+ + + VTGS+D T+++WD+ +G++ +L H V + S
Sbjct: 274 KVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS-- 329
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 330 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 387
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
W T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 388 WSTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 445
Query: 375 VRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV------- 426
VR + + SG+ D IK W + + TL +S V
Sbjct: 446 VRCIRFDNKR--IVSGAYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDE 502
Query: 427 --LVSGADNGTMHLWDW 441
++S + + T+ +WD+
Sbjct: 503 FQIISSSHDDTILIWDF 519
Score = 68.2 bits (165), Expect = 2e-11
Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
L RV+ GH V + + +++ V+ S DRTIK+W ++ + +L GH RG+ +
Sbjct: 355 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGH---KRGIACL 409
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 410 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 467
Query: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
WD+ R AS + TL H+ V R Q E QII+ SHD TI +WD +
Sbjct: 468 WDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWDFL 520
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 45/184 (24%)
Query: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG 362
+++ RD++ +IWD + + L+GHT +V + Q E I+TGS D+T+R+WD+ G
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTG 310
Query: 363 KTRVTLTNHKKSV---------------------------------RAVVLH-------- 381
+ TL +H ++V R +V H
Sbjct: 311 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 370
Query: 382 -PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440
Y ++ IK W F++ L+GH I L D ++VSG+ + T+ LWD
Sbjct: 371 FDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWD 429
Query: 441 WRTG 444
G
Sbjct: 430 IECG 433
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 15/154 (9%)
Query: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQ 397
Q + +II+G D +I++WD + + LT H SV + R +GS D+ ++
Sbjct: 247 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRV 304
Query: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDW--RTGYNFQRVHAAVQ 455
W G + L HN + L S+G++V+ + + ++ +WD T +RV
Sbjct: 305 WDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRV----- 358
Query: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+ + + FD + +++A D+TIKV+
Sbjct: 359 --LVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 388
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 99.8 bits (247), Expect = 5e-21
Identities = 77/275 (28%), Positives = 133/275 (48%), Gaps = 16/275 (5%)
Query: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279
++G D +IKIWD S + LTGH +V + R + + D V+ WD+ +
Sbjct: 220 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGE 277
Query: 280 VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNAVATV 336
V+ H AV L L + ++VTCS+D + +WD+ + + L GH AV V
Sbjct: 278 VLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 335
Query: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395
+ I++ S D TI++W + TL HK+ + L R SGS DN I
Sbjct: 336 --DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTI 391
Query: 396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455
+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + + + + +
Sbjct: 392 RLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLQAALDPRAPASTLC 450
Query: 456 PGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
+L SG +F FD E +++++ D TI ++
Sbjct: 451 LRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIW 483
Score = 97.1 bits (240), Expect = 4e-20
Identities = 71/257 (27%), Positives = 123/257 (47%), Gaps = 24/257 (9%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+V++GH G V C+ + + VTGS+D T+++WD+ +G++ +L H V + S
Sbjct: 240 KVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS-- 295
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 296 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 353
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
W T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 354 WSTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 411
Query: 375 VRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV------- 426
VR + + SG+ D IK W + + TL +S V
Sbjct: 412 VRCIRFDNKR--IVSGAYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDE 468
Query: 427 --LVSGADNGTMHLWDW 441
++S + + T+ +WD+
Sbjct: 469 FQIISSSHDDTILIWDF 485
Score = 68.2 bits (165), Expect = 2e-11
Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
L RV+ GH V + + +++ V+ S DRTIK+W ++ + +L GH RG+ +
Sbjct: 321 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGH---KRGIACL 375
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 376 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 433
Query: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
WD+ R AS + TL H+ V R Q E QII+ SHD TI +WD +
Sbjct: 434 WDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWDFL 486
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 45/184 (24%)
Query: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG 362
+++ RD++ +IWD + + L+GHT +V + Q E I+TGS D+T+R+WD+ G
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTG 276
Query: 363 KTRVTLTNHKKSV---------------------------------RAVVLH-------- 381
+ TL +H ++V R +V H
Sbjct: 277 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 336
Query: 382 -PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440
Y ++ IK W F++ L+GH I L D ++VSG+ + T+ LWD
Sbjct: 337 FDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWD 395
Query: 441 WRTG 444
G
Sbjct: 396 IECG 399
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 15/154 (9%)
Query: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQ 397
Q + +II+G D +I++WD + + LT H SV + R +GS D+ ++
Sbjct: 213 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRV 270
Query: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDW--RTGYNFQRVHAAVQ 455
W G + L HN + L S+G++V+ + + ++ +WD T +RV
Sbjct: 271 WDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRV----- 324
Query: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+ + + FD + +++A D+TIKV+
Sbjct: 325 --LVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 354
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 99.8 bits (247), Expect = 5e-21
Identities = 77/275 (28%), Positives = 133/275 (48%), Gaps = 16/275 (5%)
Query: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279
++G D +IKIWD S + LTGH +V + R + + D V+ WD+ +
Sbjct: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGE 298
Query: 280 VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNAVATV 336
V+ H AV L L + ++VTCS+D + +WD+ + + L GH AV V
Sbjct: 299 VLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 356
Query: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395
+ I++ S D TI++W + TL HK+ + L R SGS DN I
Sbjct: 357 --DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTI 412
Query: 396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455
+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + + + + +
Sbjct: 413 RLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLQAALDPRAPASTLC 471
Query: 456 PGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
+L SG +F FD E +++++ D TI ++
Sbjct: 472 LRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIW 504
Score = 97.1 bits (240), Expect = 4e-20
Identities = 71/257 (27%), Positives = 123/257 (47%), Gaps = 24/257 (9%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
+V++GH G V C+ + + VTGS+D T+++WD+ +G++ +L H V + S
Sbjct: 261 KVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS-- 316
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 317 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 374
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
W T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 375 WSTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 432
Query: 375 VRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV------- 426
VR + + SG+ D IK W + + TL +S V
Sbjct: 433 VRCIRFDNKR--IVSGAYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDE 489
Query: 427 --LVSGADNGTMHLWDW 441
++S + + T+ +WD+
Sbjct: 490 FQIISSSHDDTILIWDF 506
Score = 68.2 bits (165), Expect = 2e-11
Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
L RV+ GH V + + +++ V+ S DRTIK+W ++ + +L GH RG+ +
Sbjct: 342 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGH---KRGIACL 396
Query: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 397 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 454
Query: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
WD+ R AS + TL H+ V R Q E QII+ SHD TI +WD +
Sbjct: 455 WDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWDFL 507
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 45/184 (24%)
Query: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG 362
+++ RD++ +IWD + + L+GHT +V + Q E I+TGS D+T+R+WD+ G
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTG 297
Query: 363 KTRVTLTNHKKSV---------------------------------RAVVLH-------- 381
+ TL +H ++V R +V H
Sbjct: 298 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 357
Query: 382 -PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440
Y ++ IK W F++ L+GH I L D ++VSG+ + T+ LWD
Sbjct: 358 FDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWD 416
Query: 441 WRTG 444
G
Sbjct: 417 IECG 420
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 15/154 (9%)
Query: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQ 397
Q + +II+G D +I++WD + + LT H SV + R +GS D+ ++
Sbjct: 234 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRV 291
Query: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDW--RTGYNFQRVHAAVQ 455
W G + L HN + L S+G++V+ + + ++ +WD T +RV
Sbjct: 292 WDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRV----- 345
Query: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+ + + FD + +++A D+TIKV+
Sbjct: 346 --LVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 375
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 99.0 bits (245), Expect = 9e-21
Identities = 74/286 (25%), Positives = 111/286 (38%), Gaps = 34/286 (11%)
Query: 188 PQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK-------L 240
P P Y ++ + G + + V + G AD T+++W + KL+ L
Sbjct: 455 PDCLPSICFYTFLNAYQG-LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDL 513
Query: 241 SLT------------------------GHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLE 276
SL GH V G S YL S ED V+ W L+
Sbjct: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
Query: 277 YNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATV 336
+ Y GH V+ P V+ D AR+W + +GH V
Sbjct: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633
Query: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395
R + TGS D T+RLWD++ G T HK + ++ P A+G+ D +
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440
W G + L GH + +L + DG +L SG+ + T+ LWD
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 82.4 bits (202), Expect = 9e-16
Identities = 41/155 (26%), Positives = 70/155 (45%)
Query: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
R+ +GHL V C P + + TGSADRT+++WD+ +G TGH + + S
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
+L + D +V WD+ + ++ GH V L ++L + S D+T R+WD
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
Query: 318 RTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDT 352
T A + +++ G++ T
Sbjct: 741 IKAFEDLETDDFTTATGHINLPENSQELLLGTYMT 775
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/147 (27%), Positives = 67/147 (45%)
Query: 214 PGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW 273
P +FV+G DR ++W + GH++ V S Y+ + D+ V+ W
Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
Query: 274 DLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV 333
D+ +R + GH ++ L P L T + D +WD+ V L GHT+ V
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714
Query: 334 ATVRCQAAEPQIITGSHDTTIRLWDLV 360
++R + +GS D T+RLWD +
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWDAI 741
Score = 53.1 bits (126), Expect = 6e-07
Identities = 41/141 (29%), Positives = 57/141 (40%), Gaps = 4/141 (2%)
Query: 307 SRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRV 366
S D RI D +T + + L GH+ V +++ S D T+RLW L V
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 367 TLTNHKKSVRAVVLHPRHYTFASGSPDNI-KQWKFPDGSFIQNLSGHNAIINTLTV--NS 423
H V P Y F SG D + + W ++ +GH A +N NS
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS 639
Query: 424 DGVLVSGADNGTMHLWDWRTG 444
+ V AD T+ LWD G
Sbjct: 640 NYVATGSADR-TVRLWDVLNG 659
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 97.1 bits (240), Expect = 4e-20
Identities = 64/263 (24%), Positives = 112/263 (42%), Gaps = 11/263 (4%)
Query: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV 249
W L + H G + + + ++ D+T IWD +G+ K H +
Sbjct: 252 WTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 311
Query: 250 RGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRD 309
V + + + SC D + L ++ I+ + GH + V + PT ++L +CS D
Sbjct: 312 LDVDWQSNNTFA-SCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDD 370
Query: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAEP---------QIITGSHDTTIRLWDLV 360
T +IW ++ VH L H + T++ P + + S D+T+RLWD+
Sbjct: 371 MTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD 430
Query: 361 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTL 419
G TLT H++ V +V P ASGS D + W G+ + + G I
Sbjct: 431 RGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC 490
Query: 420 TVNSDGVLVSGADNGTMHLWDWR 442
+ + + A +G++ + D R
Sbjct: 491 WNAAGDKVGASASDGSVCVLDLR 513
Score = 65.5 bits (158), Expect = 1e-10
Identities = 78/363 (21%), Positives = 133/363 (36%), Gaps = 77/363 (21%)
Query: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLA----SGKLKLSL----- 242
PP K V+ GH V A P + +GS D T +IW+L+ SG +L L
Sbjct: 158 PPNKAV-VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIR 216
Query: 243 -------------------------TG------HISTVRGVIVST--------------- 256
TG I T G + ST
Sbjct: 217 EGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNK 276
Query: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
+ ++ S G DK WD + + + H + +D + +CS D +
Sbjct: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NTFASCSTDMCIHVCK 335
Query: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
+ + T GHTN V ++ + + S D T+++W + L H K +
Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
Query: 377 AVVLHP---------RHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG- 425
+ P + AS S D+ ++ W G I L+ H + ++ + DG
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGR 455
Query: 426 VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKT 485
L SG+ + +H+W+ +TG VH S GIF ++ + ++ + +D +
Sbjct: 456 YLASGSFDKCVHIWNTQTG---ALVH------SYRGTGGIFEVCWNAAGDKVGASASDGS 506
Query: 486 IKV 488
+ V
Sbjct: 507 VCV 509
Score = 48.9 bits (115), Expect = 1e-05
Identities = 59/226 (26%), Positives = 88/226 (38%), Gaps = 38/226 (16%)
Query: 286 GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQI 345
GH S V+ +P D+L + S DSTARIW++ S ++ SG T V C Q
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNL----SENSTSGSTQLVLR-HCIREGGQD 221
Query: 346 ITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSF 405
+ + D T W+ + TL A+GS D + DG+
Sbjct: 222 VPSNKDVTSLDWN-----SEGTL------------------LATGSYDGFARIWTKDGNL 258
Query: 406 IQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPG---SLD 460
L H I L N G +L +G D T+ +WD TG Q+ P
Sbjct: 259 ASTLGQHKGPIFALKWNKKGNFILSAGVDKTTI-IWDAHTGEAKQQFPFHSAPALDVDWQ 317
Query: 461 SESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKP 506
S + +C+ D + D+ IK ++ T E + + W P
Sbjct: 318 SNNTFASCSTDMC-IHVCKLGQDRPIKTFQGH---TNEVNAIKWDP 359
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 95.5 bits (236), Expect = 1e-19
Identities = 84/302 (27%), Positives = 131/302 (43%), Gaps = 25/302 (8%)
Query: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL-ASGKLKLSLTGHISTVRGVIVSTR 257
++SGH G V C P + DR I +W++ +L GH V + +T
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
Query: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAV---YGLDLHPTIDVLVTCSRDSTARI 314
LFS DK V WD E + ++ GH S V Y P ++ T S D T ++
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDDGTVKL 178
Query: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
WD+R KA++ T +T V V QII+G D I++WDL K T+ H S
Sbjct: 179 WDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS 237
Query: 375 VRAVVLHPRHYTFASGSPDN-IKQWKF----PDGSFIQNLSG--HNAIINTL--TVNSDG 425
V + L S + DN ++ W P ++ G HN N L + + DG
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297
Query: 426 -VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADK 484
+ +G+ + +++WD + ++ PG S I AF E +++A +DK
Sbjct: 298 SKIAAGSADRFVYVWDTTSRRILYKL-----PGHAGS---INEVAFHPDEPIIISASSDK 349
Query: 485 TI 486
+
Sbjct: 350 RL 351
Score = 92.0 bits (227), Expect = 1e-18
Identities = 60/247 (24%), Positives = 108/247 (43%), Gaps = 11/247 (4%)
Query: 197 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256
Y + GH G V + + S D+T+ +WD +G+ L GH S V +
Sbjct: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Query: 257 RSPYLFSCG-EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315
R P L G +D VK WD+ I+ + + V + + T D +++ D+ ++W
Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 316 DVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL--VAGKTRV------T 367
D+R +T+ GH ++V + + +++ + D T+R+WD+ A K R
Sbjct: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
Query: 368 LTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV 426
+ N +K++ P A+GS D + W + L GH IN + + D
Sbjct: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
Query: 427 LVSGADN 433
++ A +
Sbjct: 341 IIISASS 347
Score = 89.0 bits (219), Expect = 1e-17
Identities = 69/253 (27%), Positives = 109/253 (43%), Gaps = 7/253 (2%)
Query: 242 LTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRH--YHGHLSAVYGLDLHPT 299
L+GH V L S G D+ + W++ Y + GH AV L +
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTD 120
Query: 300 IDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWD 358
+L + S D T +WD T V L GHT+ V + PQ++ TGS D T++LWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIIN 417
+ K + + V AV + SG DN IK W + GH +
Sbjct: 181 -IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
Query: 418 TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR 476
L+++S+G L+S A + T+ +WD R +R Q + E + C++ S+
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
Query: 477 LLTAEADKTIKVY 489
+ AD+ + V+
Sbjct: 300 IAAGSADRFVYVW 312
Score = 67.4 bits (163), Expect = 3e-11
Identities = 37/148 (25%), Positives = 68/148 (45%), Gaps = 8/148 (5%)
Query: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLE--- 276
++G D IK+WDL KL ++ GH +V G+ +S+ YL S D V+ WD+
Sbjct: 209 ISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
Query: 277 -YNKVIRHYHGHL----SAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTN 331
+ ++ + G++ + P + S D +WD ++ ++ L GH
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAG 328
Query: 332 AVATVRCQAAEPQIITGSHDTTIRLWDL 359
++ V EP II+ S D + + ++
Sbjct: 329 SINEVAFHPDEPIIISASSDKRLYMGEI 356
Score = 52.0 bits (123), Expect = 1e-06
Identities = 41/179 (22%), Positives = 76/179 (42%), Gaps = 23/179 (12%)
Query: 320 KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG-KTRVTLTNHKKSVRAV 378
+A + LSGH V + + + D I LW++ TL H +V +
Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
Query: 379 VLHPRHYT------FASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSG 430
HY F++ + + W G ++ L GH + +N+ G ++ +G
Sbjct: 116 -----HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170
Query: 431 ADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
+D+GT+ LWD R AA+Q + + + A F+ + ++++ D IKV+
Sbjct: 171 SDDGTVKLWDIRK-------KAAIQ--TFQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 1/70 (1%)
Query: 207 VRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266
+RC + P GSADR + +WD S ++ L GH ++ V P + S
Sbjct: 289 LRC-SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347
Query: 267 DKQVKCWDLE 276
DK++ +++
Sbjct: 348 DKRLYMGEIQ 357
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 95.1 bits (235), Expect = 1e-19
Identities = 61/263 (23%), Positives = 110/263 (41%), Gaps = 11/263 (4%)
Query: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV 249
W L + H G + + + ++ D+T IWD +G+ K H +
Sbjct: 264 WTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 323
Query: 250 RGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRD 309
V + + SC D + L ++ ++ + GH + V + P+ +L +CS D
Sbjct: 324 LDVDWQNNTTFA-SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 382
Query: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAEP---------QIITGSHDTTIRLWDLV 360
T +IW ++ + +H L H + T++ P + + S D+T+RLWD+
Sbjct: 383 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442
Query: 361 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTL 419
G TLT H++ V +V P ASGS D + W G+ + + G I
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC 502
Query: 420 TVNSDGVLVSGADNGTMHLWDWR 442
+ + A +G++ + D R
Sbjct: 503 WNARGDKVGASASDGSVCVLDLR 525
Score = 63.2 bits (152), Expect = 6e-10
Identities = 82/407 (20%), Positives = 139/407 (34%), Gaps = 75/407 (18%)
Query: 104 PGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMN 163
P V T + ++ A + A A A A T +G +++P + + +N
Sbjct: 89 PDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKN---REATVN 145
Query: 164 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGS 223
+ N A P + P V+ GH V A P + +GS
Sbjct: 146 GEENRAHSVNNHA-----KPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGS 200
Query: 224 ADRTIKIWDL----ASGKLKLSLT------GH---------------------------- 245
D T +IW+L G +L L GH
Sbjct: 201 GDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGF 260
Query: 246 --ISTVRGVIVST---------------RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHL 288
I T G + ST + Y+ S G DK WD + + + H
Sbjct: 261 ARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHS 320
Query: 289 SAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITG 348
+ +D +CS D + + V T GHTN V ++ + + +
Sbjct: 321 APALDVDWQNN-TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASC 379
Query: 349 SHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP---------RHYTFASGSPDN-IKQW 398
S D T+++W + L H K + + P + AS S D+ ++ W
Sbjct: 380 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Query: 399 KFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTG 444
G L+ H + ++ + DG L SG+ + +H+W+ ++G
Sbjct: 440 DIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 95.1 bits (235), Expect = 1e-19
Identities = 61/263 (23%), Positives = 110/263 (41%), Gaps = 11/263 (4%)
Query: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV 249
W L + H G + + + ++ D+T IWD +G+ K H +
Sbjct: 264 WTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 323
Query: 250 RGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRD 309
V + + SC D + L ++ ++ + GH + V + P+ +L +CS D
Sbjct: 324 LDVDWQNNTTFA-SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 382
Query: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAEP---------QIITGSHDTTIRLWDLV 360
T +IW ++ + +H L H + T++ P + + S D+T+RLWD+
Sbjct: 383 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442
Query: 361 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTL 419
G TLT H++ V +V P ASGS D + W G+ + + G I
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC 502
Query: 420 TVNSDGVLVSGADNGTMHLWDWR 442
+ + A +G++ + D R
Sbjct: 503 WNARGDKVGASASDGSVCVLDLR 525
Score = 63.2 bits (152), Expect = 6e-10
Identities = 82/407 (20%), Positives = 139/407 (34%), Gaps = 75/407 (18%)
Query: 104 PGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMN 163
P V T + ++ A + A A A A T +G +++P + + +N
Sbjct: 89 PDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKN---REATVN 145
Query: 164 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGS 223
+ N A P + P V+ GH V A P + +GS
Sbjct: 146 GEENRAHSVNNHA-----KPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGS 200
Query: 224 ADRTIKIWDL----ASGKLKLSLT------GH---------------------------- 245
D T +IW+L G +L L GH
Sbjct: 201 GDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGF 260
Query: 246 --ISTVRGVIVST---------------RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHL 288
I T G + ST + Y+ S G DK WD + + + H
Sbjct: 261 ARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHS 320
Query: 289 SAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITG 348
+ +D +CS D + + V T GHTN V ++ + + +
Sbjct: 321 APALDVDWQNN-TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASC 379
Query: 349 SHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP---------RHYTFASGSPDN-IKQW 398
S D T+++W + L H K + + P + AS S D+ ++ W
Sbjct: 380 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Query: 399 KFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTG 444
G L+ H + ++ + DG L SG+ + +H+W+ ++G
Sbjct: 440 DIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 95.1 bits (235), Expect = 1e-19
Identities = 61/263 (23%), Positives = 110/263 (41%), Gaps = 11/263 (4%)
Query: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV 249
W L + H G + + + ++ D+T IWD +G+ K H +
Sbjct: 315 WTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 374
Query: 250 RGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRD 309
V + + SC D + L ++ ++ + GH + V + P+ +L +CS D
Sbjct: 375 LDVDWQNNTTFA-SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 433
Query: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAEP---------QIITGSHDTTIRLWDLV 360
T +IW ++ + +H L H + T++ P + + S D+T+RLWD+
Sbjct: 434 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 493
Query: 361 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTL 419
G TLT H++ V +V P ASGS D + W G+ + + G I
Sbjct: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC 553
Query: 420 TVNSDGVLVSGADNGTMHLWDWR 442
+ + A +G++ + D R
Sbjct: 554 WNARGDKVGASASDGSVCVLDLR 576
Score = 63.2 bits (152), Expect = 6e-10
Identities = 82/407 (20%), Positives = 139/407 (34%), Gaps = 75/407 (18%)
Query: 104 PGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMN 163
P V T + ++ A + A A A A T +G +++P + + +N
Sbjct: 140 PDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKN---REATVN 196
Query: 164 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGS 223
+ N A P + P V+ GH V A P + +GS
Sbjct: 197 GEENRAHSVNNHA-----KPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGS 251
Query: 224 ADRTIKIWDL----ASGKLKLSLT------GH---------------------------- 245
D T +IW+L G +L L GH
Sbjct: 252 GDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGF 311
Query: 246 --ISTVRGVIVST---------------RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHL 288
I T G + ST + Y+ S G DK WD + + + H
Sbjct: 312 ARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHS 371
Query: 289 SAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITG 348
+ +D +CS D + + V T GHTN V ++ + + +
Sbjct: 372 APALDVDWQNN-TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASC 430
Query: 349 SHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP---------RHYTFASGSPDN-IKQW 398
S D T+++W + L H K + + P + AS S D+ ++ W
Sbjct: 431 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490
Query: 399 KFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTG 444
G L+ H + ++ + DG L SG+ + +H+W+ ++G
Sbjct: 491 DIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,321,790
Number of Sequences: 37866
Number of extensions: 985073
Number of successful extensions: 6233
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 249
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 2986
Number of HSP's gapped (non-prelim): 1607
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.