Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4505807
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1
[Homo sapiens]
(854 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 1738 0.0
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 1738 0.0
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 393 e-109
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 193 5e-49
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 154 4e-37
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 137 4e-32
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 136 7e-32
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 130 4e-30
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 127 3e-29
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 116 8e-26
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 115 2e-25
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 112 2e-24
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 48 3e-05
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 44 6e-04
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 44 6e-04
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 38 0.035
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 38 0.035
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 38 0.035
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 38 0.035
gi|226246554 hypothetical protein LOC643677 [Homo sapiens] 36 0.17
gi|239756039 PREDICTED: hypothetical protein LOC643677 [Homo sap... 36 0.17
gi|239750569 PREDICTED: hypothetical protein LOC643677 [Homo sap... 36 0.17
gi|239744870 PREDICTED: hypothetical protein LOC643677 [Homo sap... 36 0.17
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 34 0.50
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 34 0.50
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 34 0.50
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 33 1.5
gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens] 32 2.5
gi|113411363 PREDICTED: hypothetical protein [Homo sapiens] 32 2.5
gi|113411347 PREDICTED: hypothetical protein [Homo sapiens] 32 2.5
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1
[Homo sapiens]
Length = 854
Score = 1738 bits (4500), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI 60
MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI
Sbjct: 1 MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI 60
Query: 61 AKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNA 120
AKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNA
Sbjct: 61 AKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNA 120
Query: 121 TIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVP 180
TIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVP
Sbjct: 121 TIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVP 180
Query: 181 PDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKR 240
PDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKR
Sbjct: 181 PDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKR 240
Query: 241 RTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAW 300
RTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAW
Sbjct: 241 RTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAW 300
Query: 301 SISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSH 360
SISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSH
Sbjct: 301 SISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSH 360
Query: 361 VLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY 420
VLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY
Sbjct: 361 VLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY 420
Query: 421 VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAK 480
VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAK
Sbjct: 421 VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAK 480
Query: 481 DFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDID 540
DFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDID
Sbjct: 481 DFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDID 540
Query: 541 YKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAI 600
YKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAI
Sbjct: 541 YKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAI 600
Query: 601 FKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL 660
FKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL
Sbjct: 601 FKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL 660
Query: 661 GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK 720
GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK
Sbjct: 661 GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK 720
Query: 721 GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 780
GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR
Sbjct: 721 GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 780
Query: 781 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSR 840
PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSR
Sbjct: 781 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSR 840
Query: 841 TYDMIQYYQNDIPY 854
TYDMIQYYQNDIPY
Sbjct: 841 TYDMIQYYQNDIPY 854
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 1738 bits (4500), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI 60
MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI
Sbjct: 1191 MREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEI 1250
Query: 61 AKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNA 120
AKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNA
Sbjct: 1251 AKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNA 1310
Query: 121 TIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVP 180
TIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVP
Sbjct: 1311 TIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVP 1370
Query: 181 PDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKR 240
PDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKR
Sbjct: 1371 PDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKR 1430
Query: 241 RTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAW 300
RTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAW
Sbjct: 1431 RTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAW 1490
Query: 301 SISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSH 360
SISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSH
Sbjct: 1491 SISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSH 1550
Query: 361 VLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY 420
VLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY
Sbjct: 1551 VLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGY 1610
Query: 421 VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAK 480
VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAK
Sbjct: 1611 VREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAK 1670
Query: 481 DFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDID 540
DFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDID
Sbjct: 1671 DFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDID 1730
Query: 541 YKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAI 600
YKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAI
Sbjct: 1731 YKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAI 1790
Query: 601 FKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL 660
FKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL
Sbjct: 1791 FKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL 1850
Query: 661 GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK 720
GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK
Sbjct: 1851 GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK 1910
Query: 721 GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 780
GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR
Sbjct: 1911 GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 1970
Query: 781 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSR 840
PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSR
Sbjct: 1971 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSR 2030
Query: 841 TYDMIQYYQNDIPY 854
TYDMIQYYQNDIPY
Sbjct: 2031 TYDMIQYYQNDIPY 2044
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
type 3 alpha [Homo sapiens]
Length = 286
Score = 393 bits (1009), Expect = e-109
Identities = 191/192 (99%), Positives = 192/192 (100%)
Query: 547 MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDD 606
MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFK+GDD
Sbjct: 1 MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDD 60
Query: 607 CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 666
CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF
Sbjct: 61 CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 120
Query: 667 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 726
GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI
Sbjct: 121 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180
Query: 727 DFGFMFESSPGG 738
DFGFMFESSPGG
Sbjct: 181 DFGFMFESSPGG 192
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 193 bits (491), Expect = 5e-49
Identities = 105/267 (39%), Positives = 166/267 (62%), Gaps = 7/267 (2%)
Query: 591 GQKISWQ--AAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 648
G +W+ + I K GDD RQ++LA Q++ ++I++ + L++ PY+++ + G+I
Sbjct: 563 GHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMI 622
Query: 649 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 708
E + + S Q+ +Q+ + DYF +++G +T AF A+ NF++S A Y L+ +LLQ+K
Sbjct: 623 EPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVK 682
Query: 709 DRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPD-IKLTDEMVMIMGGKMEATPFKW 767
DRHNGNI+LD +GHIIHIDFGF+ SSP NLG+E KLT E V +MGG ++ F +
Sbjct: 683 DRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNY 740
Query: 768 FMEMCVRGYLAVRPYMDAVVSLVTLMLD-TGLPCFRG-QTIKLLKHRFSPNMTEREAANF 825
+ + ++G +A R +MD VV +V +M + LPCF G TI+ LK RF +MTE +
Sbjct: 741 YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLL 800
Query: 826 IMKVIQSCFLSNRSRTYDMIQYYQNDI 852
+ +++ S ++ YD QY N I
Sbjct: 801 VEQMVDGSMRSITTKLYDGFQYLTNGI 827
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 154 bits (388), Expect = 4e-37
Identities = 140/517 (27%), Positives = 225/517 (43%), Gaps = 62/517 (11%)
Query: 338 VPEAIKFL---VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVL 394
+PE + L V W++ D A V W P P + YP P+ + V+ L
Sbjct: 561 IPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPD-PMVRGFAVRCL 619
Query: 395 RSF-PPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDE 451
+ D + Y+ Q+VQ L+Y++ + ++L A +Q + H F W++K+
Sbjct: 620 EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKS------ 673
Query: 452 EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK 511
E H K + L+E + K R+ + K+ N++ I+K K DE +K
Sbjct: 674 EMHNKT--VSQRFGLLLESYCRACGMYLKHL-NRQVEAMEKLINLTDILKQEKK-DETQK 729
Query: 512 ACLSALSEVKVQP-------GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRC 564
+ L E +P G P NP A L +++ C
Sbjct: 730 VQMKFLVEQMRRPDFMDALQGFLSPLNP--------------------AHQLGNLRLEEC 769
Query: 565 GVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIF 624
+ K L ++ D S +I IFK GDD RQDML LQII + +NI+
Sbjct: 770 RIMSSAKRPLWLNWENPDIMSELLFQNNEI-----IFKNGDDLRQDMLTLQIIRIMENIW 824
Query: 625 QLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL----GRQTDFGMYDYFTRQYGDES 680
Q GLDL + PY ++ G+IE + + + Q+ G + + Q+ +
Sbjct: 825 QNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDK 884
Query: 681 TLA--FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSP-- 736
+ A F RS A Y + F+L I DRHN NIM+ G + HIDFG +
Sbjct: 885 NKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKK 944
Query: 737 -GGNLGWEPDIKLTDEMVMIMGGKMEAT---PFKWFMEMCVRGYLAVRPYMDAVVSLVTL 792
G P + D +++I G E T F+ F EMC + YLA+R + + ++L ++
Sbjct: 945 FGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSM 1004
Query: 793 MLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFIMK 828
ML +G+P + I ++ + + TE+EA + MK
Sbjct: 1005 MLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMK 1041
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 137 bits (345), Expect = 4e-32
Identities = 123/457 (26%), Positives = 218/457 (47%), Gaps = 40/457 (8%)
Query: 391 VKVLRSFPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIY 448
V+ L S D +L Y+ Q+VQA++++ + ++L +++ + H W +++ I
Sbjct: 645 VQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA 704
Query: 449 LDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDE 508
Q+ I L + G + DF Q + + V+ IK E
Sbjct: 705 QSRHYQQRFAVI------LEAYLRGCGTAMLHDFTQ-QVQVIEMLQKVTLDIKSLSA--E 755
Query: 509 RKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSE 568
+ +S++K + N + L ++ P KA LA +++C V
Sbjct: 756 KYDVSSQVISQLKQKL-----ENLQNSQLPESFR--VPYDPGLKAGALA---IEKCKVMA 805
Query: 569 LEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVG 628
+K+ L E +C+ A + IFK GDD RQDML LQI+ + ++I++
Sbjct: 806 SKKKPLWL----EFKCADPTALSNETI--GIIFKHGDDLRQDMLILQILRIMESIWETES 859
Query: 629 LDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQT--DFGMY-DYFTRQYGDESTLA-- 683
LDL + PY ++T G+IE + D T+ ++ + T + G + D + E +
Sbjct: 860 LDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEE 919
Query: 684 -FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGN 739
FQ A F+ S A Y + F+L I DRHN NIM+ + G++ HIDFG + ++S G N
Sbjct: 920 KFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGIN 979
Query: 740 LGWEPDIKLTDEMVMIMG--GKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 797
P + LT + + +MG GK + F+ F ++CV+ YLA+R + + ++ L ++ML TG
Sbjct: 980 KERVPFV-LTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTG 1038
Query: 798 LPCFRG-QTIKLLKHRFSPNMTEREAANFIMKVIQSC 833
+P + I+ ++ + E +A + + I+ C
Sbjct: 1039 MPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVC 1075
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 136 bits (343), Expect = 7e-32
Identities = 123/490 (25%), Positives = 220/490 (44%), Gaps = 59/490 (12%)
Query: 364 WAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYD--KMGYV 421
W + P L +S +P + + V+ L + D +L Y+PQ+VQA++++ +
Sbjct: 716 WTFSQPLEALGLLTSSFPDQEIR-KVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPL 774
Query: 422 REYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKD 481
+ +L + +S +AH+ W +K + E + K +L+ + D
Sbjct: 775 VQLLLHRSLQSIQVAHRLYWLLKN---AENEAYFKS-----WYQKLLAALQFCAGKALND 826
Query: 482 FYQREFDFFNKITNVSAIIKPYPKGDERK--KACLSALSEVKVQPG-CYLPSNPEAIVLD 538
+ +E + ++ +K ++ K + L E C+LP NP +
Sbjct: 827 EFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKG 886
Query: 539 IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQA 598
ID+ + + S A K+ + + G+ IS
Sbjct: 887 IDHDACSYFTSNA-----LPLKITFINANPM---------------------GKNIS--- 917
Query: 599 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658
IFK GDD RQDML LQ+I + NI+ GLD+ + YR ++T G+++ +PD +
Sbjct: 918 IIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLA 977
Query: 659 QLGRQT-------DFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 711
++ R + + + +F++ + +++A NF S A + ++ F+L + DRH
Sbjct: 978 KIHRHSGLIGPLKENTIKKWFSQH--NHLKADYEKALRNFFYSCAGWCVVTFILGVCDRH 1035
Query: 712 NGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIKLTDEMVMIMGGKMEATPFKWF 768
N NIML K GH+ HIDFG F+ + G + + P I ++ I G F+ F
Sbjct: 1036 NDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDF 1095
Query: 769 MEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFIM 827
+E+C R Y +R + +++L+ +ML GLP G Q +K + + P T+ EA +
Sbjct: 1096 VELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFT 1155
Query: 828 KVIQ---SCF 834
K I+ CF
Sbjct: 1156 KKIKESLECF 1165
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 130 bits (328), Expect = 4e-30
Identities = 128/516 (24%), Positives = 221/516 (42%), Gaps = 61/516 (11%)
Query: 335 VSDVPEAIKFLVTWHTIDADAPELSHVLC-WAPTDPPTGLSYFSSMYPPHPLTAQYGVKV 393
VS +P + +W A P++ +L W + L + +P + + V+
Sbjct: 850 VSSLPLVLASAPSWEW--ACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR-RMAVQW 906
Query: 394 LRSFPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDE 451
+ S +L Y+PQ+VQAL+Y+ + ++L A + H F W +K +
Sbjct: 907 IGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGL---- 962
Query: 452 EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK 511
KD L+ + ++ + R+ N + ++ ++ R+
Sbjct: 963 ----KDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPS-ARQG 1017
Query: 512 ACLSALSEVK----VQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVS 567
+ L EVK + C LP +P +V I + + S A L+ V G
Sbjct: 1018 ILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLG-- 1075
Query: 568 ELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLV 627
E +R IFK GDD RQDML LQ+I + I+
Sbjct: 1076 ----ENIR-----------------------VIFKCGDDLRQDMLTLQMIRIMSKIWVQE 1108
Query: 628 GLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL-------GRQTDFGMYDYFTRQYGDES 680
GLD+ + +R +T G G++E IP+ + ++ G D + D+ + E
Sbjct: 1109 GLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED 1168
Query: 681 TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFG-FMFESSPGGN 739
+++A NFI S A + ++L I DRHN NIML GH+ HIDFG F+ + GN
Sbjct: 1169 --EYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGN 1226
Query: 740 LGWE--PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 797
+ + P + +D +I GG ++ F F+++C + Y +R + ++L+ LML G
Sbjct: 1227 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCG 1286
Query: 798 LPCFRG-QTIKLLKHRFSPNMTEREAANFIMKVIQS 832
+P + +K + P TE A + ++I+S
Sbjct: 1287 IPELSDLEDLKYVYDALRPQDTEANATTYFTRLIES 1322
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 127 bits (320), Expect = 3e-29
Identities = 121/486 (24%), Positives = 216/486 (44%), Gaps = 59/486 (12%)
Query: 364 WAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKM--GYV 421
W P L S + + + V + + D + +PQ VQAL+Y+ +
Sbjct: 934 WPALYPLIALELLDSKFADQEVRS-LAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSL 992
Query: 422 REYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKD 481
+++L A + +AH W +K ++ + + + +G LL + + L K
Sbjct: 993 VQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTK- 1051
Query: 482 FYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKV---QPGCYLPSNPEAIVLD 538
Q K+ S G R+ ++ V+ + C LP P + +
Sbjct: 1052 LVQLLGGVAEKVRQAS--------GSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKE 1103
Query: 539 IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQA 598
++ KS + S A KV + G++I+
Sbjct: 1104 LNIKSCSFFSSNA-----VPLKVTMVNADPM---------------------GEEIN--- 1134
Query: 599 AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658
+FKVG+D RQDMLALQ+I + I+ GLDL + ++ ++T G++E +P +
Sbjct: 1135 VMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLR 1194
Query: 659 QLGRQTDFGMYDYFT--------RQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDR 710
++ Q ++G+ F R+Y + S +++A NFI S A + ++L I DR
Sbjct: 1195 KI--QVEYGVTGSFKDKPLAEWLRKY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDR 1251
Query: 711 HNGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIKLTDEMVMIMGGKMEATPFKW 767
HN NIML GH+ HIDFG F+ + G+ + P + +D +I GG+ F+
Sbjct: 1252 HNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQL 1311
Query: 768 FMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFI 826
F+++C + Y +R + ++L++LM+ +GLP Q +K ++ P T+ EA F
Sbjct: 1312 FVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFF 1371
Query: 827 MKVIQS 832
++I+S
Sbjct: 1372 TRLIES 1377
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo
sapiens]
Length = 887
Score = 116 bits (291), Expect = 8e-26
Identities = 72/237 (30%), Positives = 125/237 (52%), Gaps = 13/237 (5%)
Query: 600 IFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 659
IFK GDD RQD L LQII L + + LDL + PY+V+AT+ G ++ I +
Sbjct: 634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEV 693
Query: 660 LGRQTDFGMYDYFTRQYGDES---TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIM 716
L + G F R+Y + +++S A Y ++ ++L + DRH N++
Sbjct: 694 LDTE---GSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750
Query: 717 LDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGY 776
L K G + HIDFG++ P P +KL EMV MGG ++ ++ F + C +
Sbjct: 751 LTKTGKLFHIDFGYILGRDP---KPLPPPMKLNKEMVEGMGG-TQSEQYQEFRKQCYTAF 806
Query: 777 LAVRPYMDAVVSLVTLMLDTGLPCFR---GQTIKLLKHRFSPNMTEREAANFIMKVI 830
L +R Y + +++L +LM+D +P +T+K ++ +F ++++ EA +++ +I
Sbjct: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLI 863
Score = 39.3 bits (90), Expect = 0.016
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 3/106 (2%)
Query: 343 KFL--VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPD 400
KFL V W L + W P D L SS Y +P +Y V LR +
Sbjct: 332 KFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYT-NPTVRRYAVARLRQADDE 390
Query: 401 AILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTN 446
+L Y+ Q+VQAL+Y+ ++ + SQ + + N N
Sbjct: 391 DLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGIN 436
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 115 bits (287), Expect = 2e-25
Identities = 123/501 (24%), Positives = 204/501 (40%), Gaps = 67/501 (13%)
Query: 346 VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFY 405
+ W+ ++ A + + W P L YP +Y V LR + + Y
Sbjct: 580 IKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQ-YVREYAVGCLRQMSDEELSQY 638
Query: 406 IPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDL 463
+ Q+VQ L+Y+ + ++L A ++ + W++++ +++ Q G +
Sbjct: 639 LLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQ----FGVI 694
Query: 464 LDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIK------PYPKGDERKKACLSAL 517
L+ G + +K + + NK+ ++++IK KG E CL
Sbjct: 695 LEAYCRGSVGHMKVLSK-----QVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQS 749
Query: 518 SEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCR 577
+ + P NP I+ ++ + M S K +L + K G +
Sbjct: 750 AYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLV-YNNKVFGEDSV-------- 800
Query: 578 SDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYR 637
IFK GDD RQDML LQ++ L +++ GLDL + PY
Sbjct: 801 --------------------GVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840
Query: 638 VVATAPGCGVIECIPDC-TSRDQLGRQTDFGMYDYFTR----------QYGDESTLAFQQ 686
+AT G+IE + T D ++ F + GD+ A ++
Sbjct: 841 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900
Query: 687 ARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGNLGWE 743
F S A Y + ++L I DRH+ NIM+ K G + HIDFG + F+S G
Sbjct: 901 ----FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERV 956
Query: 744 PDIKLTDEMVMIMGGKMEAT-PFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR 802
P I D + +I GK T F F + C YL +R + + ++L LML GLP
Sbjct: 957 PFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELT 1016
Query: 803 G-QTIKLLKHRFSPNMTEREA 822
+ I+ LK + +E EA
Sbjct: 1017 SVKDIQYLKDSLALGKSEEEA 1037
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 112 bits (279), Expect = 2e-24
Identities = 123/506 (24%), Positives = 205/506 (40%), Gaps = 59/506 (11%)
Query: 339 PEAIK--FLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRS 396
PEA+ LVT D ++ ++LC P P P + +K LR
Sbjct: 543 PEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRK 602
Query: 397 FPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGH 454
D + Y+ Q+VQ L+Y+ + +++L A ++ + H W++++ +++
Sbjct: 603 LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVAL 662
Query: 455 QKDPDIGDLLDQLVEEITGSLSGPAKDFYQ-REFDFFNKITNVSAIIKPYPKGDERKKAC 513
+ G +L+ T + K + N +S+ P P+ E C
Sbjct: 663 R----FGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLC 718
Query: 514 LSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEG 573
+ + ++ P +P ++ ++ + T M S K ++
Sbjct: 719 MRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMY--------------- 763
Query: 574 LRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFV 633
S +E + + G IFK GDD RQDML LQ+I L +++ GLDL +
Sbjct: 764 ------SNEEAGSGGSVG-------IIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRM 810
Query: 634 FPYRVVATAPGCGVIECI--PDCTSRDQLGRQTDFGMYDYFTRQYGDESTL--------- 682
PY + T G+IE + D + QL + T + ++ L
Sbjct: 811 TPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAA-----TAAFNKDALLNWLKSKNPG 865
Query: 683 -AFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGG 738
A +A F S A Y + ++L I DRH+ NIM+ + G + HIDFG F++ G
Sbjct: 866 EALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGI 925
Query: 739 NLGWEPDIKLTDEMVMIMGGKM-EATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 797
N P I D + +I GK + F+ F C R Y +R + + L LM G
Sbjct: 926 NRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAG 985
Query: 798 LPCFR-GQTIKLLKHRFSPNMTEREA 822
LP + I+ LK + TE EA
Sbjct: 986 LPELSCSKDIQYLKDSLALGKTEEEA 1011
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/47 (48%), Positives = 33/47 (70%), Gaps = 1/47 (2%)
Query: 688 RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHIDFGFMFE 733
R N+ RS+A S++ ++L + DRH N+MLD+ G I+HIDFG FE
Sbjct: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFE 2363
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 669 YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 727
+++F R + D ++ + +R + RS A S++ ++L + DRH NI+ D G +H+D
Sbjct: 2437 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 2494
Query: 728 FGFMFESSPGGNLGWEPDIKLTDEMVMIMG 757
F +F + +LT MV MG
Sbjct: 2495 FNCLFNKGETFEVPEIVPFRLTHNMVNGMG 2524
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 669 YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 727
+++F R + D ++ + +R + RS A S++ ++L + DRH NI+ D G +H+D
Sbjct: 179 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 236
Query: 728 FGFMFESSPGGNLGWEPDIKLTDEMVMIMG 757
F +F + +LT MV MG
Sbjct: 237 FNCLFNKGETFEVPEIVPFRLTHNMVNGMG 266
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 38.1 bits (87), Expect = 0.035
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 668 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 726
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 1482 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540
Query: 727 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 782
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 1541 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 1593
Query: 783 MDAVVSLVTLML 794
+ ++++V ++L
Sbjct: 1594 QETLLTIVEVLL 1605
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 38.1 bits (87), Expect = 0.035
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 668 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 726
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 2830 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888
Query: 727 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 782
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 2889 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 2941
Query: 783 MDAVVSLVTLML 794
+ ++++V ++L
Sbjct: 2942 QETLLTIVEVLL 2953
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 38.1 bits (87), Expect = 0.035
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 668 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 726
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 2708 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2766
Query: 727 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 782
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 2767 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 2819
Query: 783 MDAVVSLVTLML 794
+ ++++V ++L
Sbjct: 2820 QETLLTIVEVLL 2831
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 38.1 bits (87), Expect = 0.035
Identities = 17/69 (24%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 690 NFIRSMAAYSLLLFLLQIKDRHNGNIMLD-KKGHIIHIDFGFMFESSPGGNLGWEPDIKL 748
++ RS A S++ +++ + DRH N+++D G ++HID+ FE + + ++
Sbjct: 2316 SYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRM 2375
Query: 749 TDEMVMIMG 757
T + +G
Sbjct: 2376 TQNIETALG 2384
>gi|226246554 hypothetical protein LOC643677 [Homo sapiens]
Length = 7081
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 445 TNIYLDEEGHQKDPDIGDLLDQLVE--EITGSLSGPAKDFYQREFDFFNKITNVSAIIKP 502
T YL E HQK + G+ D + +IT + AKD+ Q++ D KI+ I+ P
Sbjct: 4113 TRYYLPELSHQKSSEAGEKADGVASKGDITIKVQ-KAKDYMQQKEDDEVKISAKKDIMHP 4171
Query: 503 YPKGDERKKACLSALSEVKVQPG 525
KG + KKA L +PG
Sbjct: 4172 EDKGLKAKKALSQDLPLNTKEPG 4194
>gi|239756039 PREDICTED: hypothetical protein LOC643677 [Homo sapiens]
Length = 6929
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 445 TNIYLDEEGHQKDPDIGDLLDQLVE--EITGSLSGPAKDFYQREFDFFNKITNVSAIIKP 502
T YL E HQK + G+ D + +IT + AKD+ Q++ D KI+ I+ P
Sbjct: 4042 TRYYLPELSHQKSSEAGEKADGVASKGDITIKVQ-KAKDYMQQKEDDEVKISAKKDIMHP 4100
Query: 503 YPKGDERKKACLSALSEVKVQPG 525
KG + KKA L +PG
Sbjct: 4101 EDKGLKAKKALSQDLPLNTKEPG 4123
>gi|239750569 PREDICTED: hypothetical protein LOC643677 [Homo sapiens]
Length = 6929
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 445 TNIYLDEEGHQKDPDIGDLLDQLVE--EITGSLSGPAKDFYQREFDFFNKITNVSAIIKP 502
T YL E HQK + G+ D + +IT + AKD+ Q++ D KI+ I+ P
Sbjct: 4042 TRYYLPELSHQKSSEAGEKADGVASKGDITIKVQ-KAKDYMQQKEDDEVKISAKKDIMHP 4100
Query: 503 YPKGDERKKACLSALSEVKVQPG 525
KG + KKA L +PG
Sbjct: 4101 EDKGLKAKKALSQDLPLNTKEPG 4123
>gi|239744870 PREDICTED: hypothetical protein LOC643677 [Homo sapiens]
Length = 6929
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 445 TNIYLDEEGHQKDPDIGDLLDQLVE--EITGSLSGPAKDFYQREFDFFNKITNVSAIIKP 502
T YL E HQK + G+ D + +IT + AKD+ Q++ D KI+ I+ P
Sbjct: 4042 TRYYLPELSHQKSSEAGEKADGVASKGDITIKVQ-KAKDYMQQKEDDEVKISAKKDIMHP 4100
Query: 503 YPKGDERKKACLSALSEVKVQPG 525
KG + KKA L +PG
Sbjct: 4101 EDKGLKAKKALSQDLPLNTKEPG 4123
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 34.3 bits (77), Expect = 0.50
Identities = 43/168 (25%), Positives = 60/168 (35%), Gaps = 32/168 (19%)
Query: 600 IFKVGDDCRQDMLALQIIDLFKNIF-QLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658
+ K G+D RQD Q+ + I Q R + P P C +D
Sbjct: 3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKD 3810
Query: 659 QLGRQT---DFGMY-------------------------DYFTRQYGDESTL--AFQQAR 688
L + + D G Y D R + ST AF R
Sbjct: 3811 WLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALR 3870
Query: 689 YNFIRSMAAYSLLLFLLQIKDRHNGNIMLD-KKGHIIHIDFGFMFESS 735
+F S A + ++L I DRH N M+ + G +I IDFG F S+
Sbjct: 3871 SHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSA 3918
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 34.3 bits (77), Expect = 0.50
Identities = 43/168 (25%), Positives = 60/168 (35%), Gaps = 32/168 (19%)
Query: 600 IFKVGDDCRQDMLALQIIDLFKNIF-QLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRD 658
+ K G+D RQD Q+ + I Q R + P P C +D
Sbjct: 3750 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKD 3809
Query: 659 QLGRQT---DFGMY-------------------------DYFTRQYGDESTL--AFQQAR 688
L + + D G Y D R + ST AF R
Sbjct: 3810 WLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALR 3869
Query: 689 YNFIRSMAAYSLLLFLLQIKDRHNGNIMLD-KKGHIIHIDFGFMFESS 735
+F S A + ++L I DRH N M+ + G +I IDFG F S+
Sbjct: 3870 SHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSA 3917
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 34.3 bits (77), Expect = 0.50
Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 5/110 (4%)
Query: 176 SQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHK 235
S+L + DT+ N + G T+ P +S+ S M K S++ +
Sbjct: 1801 SKLDSHSDDDTKDNKATSPGPTDLETRS-----PSPISISSSETSSIMQKLKKMRSRMDE 1855
Query: 236 YYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYI 285
++ +R L E L+ W L A E E+ Q + ++A W + I
Sbjct: 1856 KFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELI 1905
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 32.7 bits (73), Expect = 1.5
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 683 AFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLD-KKGHIIHIDFGFMFESS 735
AF R +F S A + ++L I DRH N M+ + G +I IDFG F S+
Sbjct: 3896 AFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSA 3949
>gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]
Length = 4753
Score = 32.0 bits (71), Expect = 2.5
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 14/74 (18%)
Query: 253 ERLITWYNPLSAPELE--LDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQL 310
E L TW PL+ PEL+ L G ++L E W D ++L + LA +
Sbjct: 179 EELATWLRPLTLPELQRCLGIVGAQ---------VALEEAVWLDGLSL---LPLALAADI 226
Query: 311 PARFKNTEAIGNEV 324
P R+++++ EV
Sbjct: 227 PVRYESSDTDNAEV 240
>gi|113411363 PREDICTED: hypothetical protein [Homo sapiens]
Length = 168
Score = 32.0 bits (71), Expect = 2.5
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 111 LLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQG 148
+L ++P R +L K+ AFD+ CPP P++G
Sbjct: 15 ILQGPLLPMKDTREMLLRKLELCAFDHLVCPPILPSEG 52
>gi|113411347 PREDICTED: hypothetical protein [Homo sapiens]
Length = 168
Score = 32.0 bits (71), Expect = 2.5
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 111 LLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQG 148
+L ++P R +L K+ AFD+ CPP P++G
Sbjct: 15 ILQGPLLPMKDTREMLLRKLELCAFDHLVCPPILPSEG 52
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,967,537
Number of Sequences: 37866
Number of extensions: 1468261
Number of successful extensions: 3543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 3470
Number of HSP's gapped (non-prelim): 69
length of query: 854
length of database: 18,247,518
effective HSP length: 111
effective length of query: 743
effective length of database: 14,044,392
effective search space: 10434983256
effective search space used: 10434983256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.