Search of human proteins with 4505771

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform
A [Homo sapiens]
         (1279 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...  2489   0.0  
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...  2482   0.0  
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...  2371   0.0  
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...  1902   0.0  
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...  1249   0.0  
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ...   951   0.0  
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...   349   1e-95
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ...   318   2e-86
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ...   314   3e-85
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member...   314   3e-85
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ...   295   2e-79
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho...   258   3e-68
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is...   243   7e-64
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa...   236   1e-61
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform...   235   2e-61
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is...   223   9e-58
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor...   220   8e-57
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor...   216   9e-56
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor...   214   6e-55
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor...   214   6e-55
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor...   210   6e-54
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s...   207   4e-53
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ...   207   5e-53
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor...   182   2e-45
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor...   166   1e-40
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor...   153   1e-36
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member...   149   1e-35
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]           149   2e-35
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor...   145   3e-34
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor...   145   3e-34

>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
            [Homo sapiens]
          Length = 1279

 Score = 2489 bits (6451), Expect = 0.0
 Identities = 1279/1279 (100%), Positives = 1279/1279 (100%)

Query: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
            MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60

Query: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
            TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120

Query: 121  SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
            SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121  SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180

Query: 181  ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
            ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181  ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240

Query: 241  FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
            FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241  FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300

Query: 301  MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
            MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301  MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360

Query: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
            RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420

Query: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
            SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480

Query: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
            LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540

Query: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
            IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600

Query: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
            AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660

Query: 661  RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
            RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661  RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720

Query: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
            NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780

Query: 781  EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
            EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781  EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840

Query: 841  NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
            NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841  NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900

Query: 901  ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
            ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA
Sbjct: 901  ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960

Query: 961  YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
            YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 961  YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020

Query: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
            SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080

Query: 1081 LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS 1140
            LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS
Sbjct: 1081 LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS 1140

Query: 1141 QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE 1200
            QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE
Sbjct: 1141 QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE 1200

Query: 1201 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260
            ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL
Sbjct: 1201 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260

Query: 1261 AQKGIYFSMVSVQAGTQNL 1279
            AQKGIYFSMVSVQAGTQNL
Sbjct: 1261 AQKGIYFSMVSVQAGTQNL 1279


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
            [Homo sapiens]
          Length = 1286

 Score = 2482 bits (6433), Expect = 0.0
 Identities = 1279/1286 (99%), Positives = 1279/1286 (99%), Gaps = 7/1286 (0%)

Query: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
            MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60

Query: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
            TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120

Query: 121  SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
            SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121  SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180

Query: 181  ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
            ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181  ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240

Query: 241  FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
            FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241  FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300

Query: 301  MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
            MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301  MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360

Query: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
            RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420

Query: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
            SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480

Query: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
            LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540

Query: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
            IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600

Query: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
            AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660

Query: 661  RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
            RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661  RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720

Query: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
            NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780

Query: 781  EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
            EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781  EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840

Query: 841  NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
            NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841  NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900

Query: 901  ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
            ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA
Sbjct: 901  ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960

Query: 961  YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
            YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 961  YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020

Query: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
            SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080

Query: 1081 LLERFYDPLAGTV-------LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1133
            LLERFYDPLAGTV       LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG
Sbjct: 1081 LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1140

Query: 1134 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1193
            DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP
Sbjct: 1141 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1200

Query: 1194 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1253
            QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
Sbjct: 1201 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1260

Query: 1254 GTHQQLLAQKGIYFSMVSVQAGTQNL 1279
            GTHQQLLAQKGIYFSMVSVQAGTQNL
Sbjct: 1261 GTHQQLLAQKGIYFSMVSVQAGTQNL 1286


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
            [Homo sapiens]
          Length = 1232

 Score = 2371 bits (6145), Expect = 0.0
 Identities = 1232/1279 (96%), Positives = 1232/1279 (96%), Gaps = 47/1279 (3%)

Query: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
            MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60

Query: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
            TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120

Query: 121  SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
            SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121  SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180

Query: 181  ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
            ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181  ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240

Query: 241  FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
            FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241  FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300

Query: 301  MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
            MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301  MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360

Query: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
            RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420

Query: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
            SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480

Query: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
            LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540

Query: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
            IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600

Query: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
            AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660

Query: 661  RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
            RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661  RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720

Query: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
            NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780

Query: 781  EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
            EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781  EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840

Query: 841  NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
            NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841  NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900

Query: 901  ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
            ENIRTVVSLTQERKFESMYVEKLYGPYR                                
Sbjct: 901  ENIRTVVSLTQERKFESMYVEKLYGPYR-------------------------------- 928

Query: 961  YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
                           VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 929  ---------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 973

Query: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
            SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 974  SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1033

Query: 1081 LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS 1140
            LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS
Sbjct: 1034 LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS 1093

Query: 1141 QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE 1200
            QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE
Sbjct: 1094 QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE 1153

Query: 1201 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260
            ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL
Sbjct: 1154 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1213

Query: 1261 AQKGIYFSMVSVQAGTQNL 1279
            AQKGIYFSMVSVQAGTQNL
Sbjct: 1214 AQKGIYFSMVSVQAGTQNL 1232


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
            sapiens]
          Length = 1280

 Score = 1902 bits (4927), Expect = 0.0
 Identities = 977/1289 (75%), Positives = 1117/1289 (86%), Gaps = 23/1289 (1%)

Query: 1    MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
            MDLE  +NG A +    +  F+L   S++ +K+ K    + V ++FRYS+W DKL+M +G
Sbjct: 1    MDLEGDRNGGAKK----KNFFKLNNKSEKDKKEKKPT--VSVFSMFRYSNWLDKLYMVVG 54

Query: 61   TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKI--------LEEE 112
            T+ AI HG+GLPLMM+VFGEMTD F + AGN     +   ++ N   I        LEE+
Sbjct: 55   TLAAIIHGAGLPLMMLVFGEMTDIFAN-AGNLE---DLMSNITNRSDINDTGFFMNLEED 110

Query: 113  MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
            MTRYAYYYSG+GAGVLVAAYIQVSFW LAAGRQI KIR++FFHAI+RQEIGWFD++D  E
Sbjct: 111  MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGE 170

Query: 173  LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
            LNTRLTDD+SKI+EGIGDK+GMFFQ++ATFF GFIVGF RGWKLTLVI+AISP+LGLSAA
Sbjct: 171  LNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 230

Query: 233  VWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIK 292
            VWAKILS+F+DKEL AYAKAGAVAEE L AIRTVIAFGGQ KELERY K+LE AK IGIK
Sbjct: 231  VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIK 290

Query: 293  KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAP 352
            KAI+ANIS+G AFLLIYASYALAFWYG+TLV+S EY+IG  +TVFFS+LIGAFSVGQA+P
Sbjct: 291  KAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350

Query: 353  CIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
             I+AFANARGAAY IF IIDN P IDS+S+ GHKPD+IKGNLEF +VHFSYPSR  VKIL
Sbjct: 351  SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKIL 410

Query: 413  KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
            KGLNLKVQSGQTVALVG+SGCGKSTTVQL+QRLYDP EG +++DGQDIR  NV +LREII
Sbjct: 411  KGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREII 470

Query: 473  GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
            GVVSQEPVLF+TTIAENI YGR NVTMDEI+KAVKEANAY+FIMKLP KFDTLVGERGAQ
Sbjct: 471  GVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ 530

Query: 533  LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
            LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VQ ALDKAR+GRTTIVIAHRLS
Sbjct: 531  LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLS 590

Query: 593  TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEF--ELNDEKAA 650
            TVRNADVIAGF+DGVIVE+G+H ELMK++G+YFKLV MQT+G++++ E    E   E  A
Sbjct: 591  TVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA 650

Query: 651  TRMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWP 709
              M+ N  +S L R  ST+++++ SQ   + L  + + L+ ++PPVSF +++KLN TEWP
Sbjct: 651  LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK-EALDESIPPVSFWRIMKLNLTEWP 709

Query: 710  YFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFT 768
            YFVVG  CAI NGGLQPAF++IFS+II +F   DD   K+Q  N+FSL+FL LGIISF T
Sbjct: 710  YFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769

Query: 769  FFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGAT 828
            FFLQGFTFGKAGEILT+RLR M F++MLRQD+SWFDD KN+TGAL+TRLA DAAQV+GA 
Sbjct: 770  FFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAI 829

Query: 829  GTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE 888
            G+RLA+I QNIANLGTGIIISFIYGWQLTLLLLA+VPIIA++G+VEMK+L+G A +DKKE
Sbjct: 830  GSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 889

Query: 889  LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFM 948
            LE +GKIATEAIEN RTVVSLTQE+KFE MY + L  PYRNS++KAHI+GITFS +QA M
Sbjct: 890  LEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 949

Query: 949  YFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
            YFSYAGCFRFGAYL+ +  M F DV+LVFSA+VFGA+A+G  SSFAPDYAKAK+SAAH+ 
Sbjct: 950  YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 1009

Query: 1009 MLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1068
            M+ E+ PLIDSYS EGL P+  EGN+TF EVVFNYPTR ++PVLQGLSLEVKKGQTLALV
Sbjct: 1010 MIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1069

Query: 1069 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1128
            GSSGCGKSTVVQLLERFYDPLAG VLLDG+E K+LNVQWLRA LGIVSQEPILFDCSIAE
Sbjct: 1070 GSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAE 1129

Query: 1129 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1188
            NIAYGDNSRVVSQ+EIV AAK ANIH FIE+LP+KY T+VGDKGTQLSGGQKQRIAIARA
Sbjct: 1130 NIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARA 1189

Query: 1189 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1248
            L+RQP ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG
Sbjct: 1190 LVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1249

Query: 1249 RVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
            RVKEHGTHQQLLAQKGIYFSMVSVQAGT+
Sbjct: 1250 RVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
            [Homo sapiens]
          Length = 1321

 Score = 1249 bits (3232), Expect = 0.0
 Identities = 648/1293 (50%), Positives = 875/1293 (67%), Gaps = 56/1293 (4%)

Query: 26   SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
            S  Q  KK   V+ +G   LFR+S   D   M +G++ A  HG   P ++++FG MTD F
Sbjct: 32   SRLQDEKKGDGVR-VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVF 90

Query: 86   VD--------------TAGNFSFPVNFSLS----------LLNPGKILEEEMTRYAYYYS 121
            +D                 N     N SL+          LLN    +E EM ++A YY+
Sbjct: 91   IDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLN----IESEMIKFASYYA 146

Query: 122  GLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDI 181
            G+   VL+  YIQ+ FW +AA RQI+K+R+ +F  I+R EIGWFD N   ELNTR +DDI
Sbjct: 147  GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDI 206

Query: 182  SKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAF 241
            +KI++ I D++ +F Q + +   GF++GF RGWKLTLVI+++SP++G+ AA     +S F
Sbjct: 207  NKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKF 266

Query: 242  SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISM 301
            +D EL AYAKAG VA+E + ++RTV AFGG+ +E+ERY+K+L  A+  GI+K I      
Sbjct: 267  TDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 326

Query: 302  GIAFLLIYASYALAFWYGSTLVISK-EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
            G  + LI+  YALAFWYGSTLV+ + EYT G  + +F S+++GA ++G A+PC++AFA  
Sbjct: 327  GFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 386

Query: 361  RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
            R AA  IF+ ID  P ID  SE G+K D IKG +EF++V F YPSR  VKIL  LN+ ++
Sbjct: 387  RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK 446

Query: 421  SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
             G+  ALVG SG GKST +QLIQR YDP EG + +DG DIR+ N+ +LR+ IG+V QEPV
Sbjct: 447  PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPV 506

Query: 481  LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
            LFSTTIAENI YGR + TM++I +A KEANAY FIM LPQ+FDTLVGE G Q+SGGQKQR
Sbjct: 507  LFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR 566

Query: 541  IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
            +AIARAL+RNPKILLLD ATSALD ESEA VQ  L K + G T I +AHRLSTVR AD I
Sbjct: 567  VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTI 626

Query: 601  AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR--MAPNGW 658
             GFE G  VE+G+H EL++++GVYF LV +Q+ G+Q  +EE    D K AT   M    +
Sbjct: 627  IGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEE----DIKDATEDDMLARTF 682

Query: 659  KSRLFRHSTQKNLKNSQMCQKSLDV--------------ETDGLEANVP------PVSFL 698
                ++ S + +++     Q S  V              E D  + ++P      P    
Sbjct: 683  SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVR 742

Query: 699  KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIF 758
            ++LK +  EWPY +VG+V A  NG + P ++ +FS+I+  F   D   ++ + N   L+F
Sbjct: 743  RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802

Query: 759  LFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 818
            + +G +S FT FLQG+ F K+GE+LT+RLR   F+AML QD++WFDD +NS GAL+TRLA
Sbjct: 803  VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862

Query: 819  TDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLL 878
            TDA+QVQGA G+++ +I  +  N+   +II+F + W+L+L++L   P +A+SG  + ++L
Sbjct: 863  TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922

Query: 879  AGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
             G A RDK+ LE  G+I  EA+ NIRTV  + +ER+F      +L  P++ ++QKA+IYG
Sbjct: 923  TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982

Query: 939  ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYA 998
              F+ +Q  M+ + +  +R+G YLI N  + F  V  V SA+V  A ALG A S+ P YA
Sbjct: 983  FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042

Query: 999  KAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLE 1058
            KAK+SAA  F L +RQP I  Y+  G K D F+G I F +  F YP+R +  VL GLS+ 
Sbjct: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1102

Query: 1059 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQE 1118
            +  GQTLA VGSSGCGKST +QLLERFYDP  G V++DG ++KK+NVQ+LR+ +GIVSQE
Sbjct: 1103 ISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQE 1162

Query: 1119 PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGG 1178
            P+LF CSI +NI YGDN++ +  + +++AAK A +H F+ +LP KYET VG +G+QLS G
Sbjct: 1163 PVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1222

Query: 1179 QKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQN 1238
            +KQRIAIARA++R P+ILLLDEATSALDTESEK VQ ALDKAREGRTCIVIAHRLSTIQN
Sbjct: 1223 EKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQN 1282

Query: 1239 ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271
            AD+I V   G V E GTH++L+AQKG Y+ +V+
Sbjct: 1283 ADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315



 Score =  392 bits (1007), Expect = e-108
 Identities = 229/653 (35%), Positives = 365/653 (55%), Gaps = 50/653 (7%)

Query: 667  TQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--WPYFVVGTVCAIANGGL 724
            + K+  N +  +   + + DG+      V F ++ + + +   W  FV G++CA  +G  
Sbjct: 22   SDKSYNNDKKSRLQDEKKGDGVR-----VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIA 75

Query: 725  QPAFSVIFSEIIAIFG-----------PGDDAVKQQ----------------KCNI---- 753
            QP   +IF  +  +F            PG   V                   +C +    
Sbjct: 76   QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135

Query: 754  -----FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKN 808
                 F+  +  + +    T ++Q   +  A     +++R   F+ ++R ++ WFD   N
Sbjct: 136  SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--N 193

Query: 809  STGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIA 868
            S G L+TR + D  ++  A   ++AL  Q + +   G ++ F  GW+LTL++++V P+I 
Sbjct: 194  SVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIG 253

Query: 869  VSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
            +        ++     + K    AG +A E I ++RTV +   E++    Y + L    R
Sbjct: 254  IGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQR 313

Query: 929  NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVN-GHMRFRDVILVFSAIVFGAVAL 987
              ++K  + G         ++  YA  F +G+ L+++ G      ++ +F +++ GA+ L
Sbjct: 314  WGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNL 373

Query: 988  GHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRA 1047
            G+AS     +A  + +A  +F   +R+P+ID  SE+G K D+ +G I F+ V F+YP+R 
Sbjct: 374  GNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433

Query: 1048 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQW 1107
             V +L  L++ +K G+  ALVG SG GKST +QL++RFYDP  G V +DG + + LN+QW
Sbjct: 434  EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493

Query: 1108 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1167
            LR Q+GIV QEP+LF  +IAENI YG      + ++IV AAK AN + FI  LP +++T 
Sbjct: 494  LRDQIGIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDLPQQFDTL 551

Query: 1168 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCI 1227
            VG+ G Q+SGGQKQR+AIARALIR P+ILLLD ATSALD ESE +VQE L K + G T I
Sbjct: 552  VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTII 611

Query: 1228 VIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA-GTQNL 1279
             +AHRLST++ AD I+ F++G   E GTH++LL +KG+YF++V++Q+ G Q L
Sbjct: 612  SVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664


>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
            sapiens]
          Length = 812

 Score =  951 bits (2458), Expect = 0.0
 Identities = 478/820 (58%), Positives = 627/820 (76%), Gaps = 11/820 (1%)

Query: 455  IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEF 514
            +D  DIR  NV + R+ IGVVSQEPVLF TTI+ NI YGR +VT +E+++A +EANAY+F
Sbjct: 2    VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61

Query: 515  IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAA 574
            IM+ P KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQAA
Sbjct: 62   IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121

Query: 575  LDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
            L+KA +GRTTIV+AHRLST+R+AD+I   +DG++ E+G+H+ELM K G+Y+ LV      
Sbjct: 122  LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV------ 175

Query: 635  SQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
                S++ +  DE+  +       K+      + K++K S    K+ +  T   E ++P 
Sbjct: 176  ---MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIK-SDFIDKA-EESTQSKEISLPE 230

Query: 695  VSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIF 754
            VS LK+LKLNK EWP+ V+GT+ ++ NG + P FS+IF++II +FG  D    +    I+
Sbjct: 231  VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290

Query: 755  SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS 814
            S+IF+ LG+I F ++F+QG  +G+AGEILT RLR +AFKAML QD++WFD+ +NSTG L+
Sbjct: 291  SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350

Query: 815  TRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVE 874
            T LA D AQ+QGATG+R+ ++ QN  N+G  +IISFIYGW++T L+L++ P++AV+G++E
Sbjct: 351  TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410

Query: 875  MKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKA 934
               + G A +DK+EL+ AGKIATEA+ENIRT+VSLT+E+ FE MY E L   +RN+ +KA
Sbjct: 411  TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470

Query: 935  HIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFA 994
             I G  ++ S AF+YF+YA  FRFGAYLI  G M    + +VF+AI +GA+A+G     A
Sbjct: 471  QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530

Query: 995  PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1054
            P+Y+KAK  AAHLF L E++P IDS S+EG KPD  EGN+ F EV F YP R +V +L+G
Sbjct: 531  PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590

Query: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1114
            LSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G VL DG +AK+LNVQWLR+Q+ I
Sbjct: 591  LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650

Query: 1115 VSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQ 1174
            V QEP+LF+CSIAENIAYGDNSRVV  DEI  AA AANIH FIE LP KY T+VG KG Q
Sbjct: 651  VPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQ 710

Query: 1175 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1234
            LSGGQKQR+AIARAL+++P+ILLLDEATSALD +SEKVVQ ALDKAR GRTC+V+ HRLS
Sbjct: 711  LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLS 770

Query: 1235 TIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274
             IQNADLIVV  NG++KE GTHQ+LL  + IYF +V+ Q+
Sbjct: 771  AIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810



 Score =  429 bits (1104), Expect = e-120
 Identities = 244/611 (39%), Positives = 362/611 (59%), Gaps = 24/611 (3%)

Query: 26  SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
           S++ K      V ++ +L L +  +W    F+ LGT+ ++ +G+  P+  I+F ++   F
Sbjct: 220 STQSKEISLPEVSLLKILKLNK-PEWP---FVVLGTLASVLNGTVHPVFSIIFAKIITMF 275

Query: 86  VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQ 145
               GN            N    L+ +   Y+  +  LG    V+ ++Q  F+  A    
Sbjct: 276 ----GN------------NDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEIL 319

Query: 146 IRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
             ++R   F A+L Q+I WFD   N T  L T L  DI++I    G ++G+  Q      
Sbjct: 320 TMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMG 379

Query: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
              I+ FI GW++T +I++I+P+L ++  +    ++ F++K+      AG +A EAL  I
Sbjct: 380 LSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENI 439

Query: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
           RT+++   +    + Y++ L+       KKA         +   IY +YA  F +G+ L+
Sbjct: 440 RTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI 499

Query: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
            +   T      VF +I  GA ++G+       ++ A+  A  +F +++  P IDS S+ 
Sbjct: 500 QAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQE 559

Query: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
           G KPD+ +GNLEF +V F YP R +V IL+GL+L ++ G+TVA VGSSGCGKST+VQL+Q
Sbjct: 560 GKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQ 619

Query: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDE 501
           RLYDP +G +  DG D +  NV +LR  I +V QEPVLF+ +IAENI YG  +  V +DE
Sbjct: 620 RLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE 679

Query: 502 IKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561
           IK+A   AN + FI  LP+K++T VG +GAQLSGGQKQR+AIARAL++ PKILLLDEATS
Sbjct: 680 IKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739

Query: 562 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE 621
           ALD +SE  VQ ALDKAR GRT +V+ HRLS ++NAD+I    +G I EQG+H EL++  
Sbjct: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799

Query: 622 GVYFKLVNMQT 632
            +YFKLVN Q+
Sbjct: 800 DIYFKLVNAQS 810



 Score =  194 bits (494), Expect = 3e-49
 Identities = 97/180 (53%), Positives = 137/180 (76%), Gaps = 2/180 (1%)

Query: 1094 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1153
            ++D  + + LNV+  R  +G+VSQEP+LF  +I+ NI YG +   V+ +E+  AA+ AN 
Sbjct: 1    MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58

Query: 1154 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1213
            + FI   P+K+ T VG+KG Q+SGGQKQRIAIARAL+R P+IL+LDEATSALD+ES+  V
Sbjct: 59   YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118

Query: 1214 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
            Q AL+KA +GRT IV+AHRLSTI++ADLIV  ++G + E G H +L+A++G+Y+S+V  Q
Sbjct: 119  QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score =  349 bits (895), Expect = 1e-95
 Identities = 204/533 (38%), Positives = 299/533 (56%), Gaps = 4/533 (0%)

Query: 104 NPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIG 163
           NP     + +TR     S +      A  I+V     +  R + ++R   F +ILRQE+ 
Sbjct: 202 NPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 261

Query: 164 WFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
           +FD   T EL  RL+ D + +   + + +    +A A    G  + F     L   ++++
Sbjct: 262 FFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSV 321

Query: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
            P + + A ++ + L   +     + A+A  +AEE +G +RTV AFG +  E+E+Y   +
Sbjct: 322 VPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKV 381

Query: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
           ++  ++  K+A +     G   L          + G  L+ S   T+G   +        
Sbjct: 382 DHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWV 441

Query: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
             S+G  +          GA   ++++++  PK+           S +G LEF +VHF+Y
Sbjct: 442 GISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAY 501

Query: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
           P+R  V I +  +L + SG   ALVG SG GKST + L+ RLYDP  GTI++DG DIR  
Sbjct: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561

Query: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGR---GNVTMDEIKKAVKEANAYEFIMKLPQ 520
           N  +LR  IG VSQEP+LFS +IAENI YG     +VT +EI++  + ANA  FI   PQ
Sbjct: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621

Query: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKARE 580
            F+T+VGE+G  LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E  VQ ALD+  +
Sbjct: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD 681

Query: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQT 632
           GRT +VIAHRLST++NA+++A  + G I E G H EL+ K  G+Y KL+N Q+
Sbjct: 682 GRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734



 Score =  330 bits (846), Expect = 5e-90
 Identities = 198/502 (39%), Positives = 293/502 (58%), Gaps = 12/502 (2%)

Query: 779  AGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQN 838
            +G+ +  RLR+  F ++LRQ++++FD  K  TG L  RL++D A +  +    L+   + 
Sbjct: 239  SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296

Query: 839  IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
             A    GI + F     L   +L+VVP +++  ++  + L    K  +  L  A ++A E
Sbjct: 297  GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356

Query: 899  AIENIRTVVS----LTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG 954
             I N+RTV +    +T+  K+ S     +    + +  +A  +G T  +S   +  S   
Sbjct: 357  RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGAT-GLSGNLIVLSV-- 413

Query: 955  CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ 1014
                G  L+ + HM   ++        +  +++G  SSF  +  K   +   L+ L ER+
Sbjct: 414  -LYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472

Query: 1015 PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
            P +       L    F+G + F  V F YP R  VP+ Q  SL +  G   ALVG SG G
Sbjct: 473  PKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSG 532

Query: 1075 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG- 1133
            KSTV+ LL R YDP +GT+ LDG + ++LN  WLR+++G VSQEPILF CSIAENIAYG 
Sbjct: 533  KSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGA 592

Query: 1134 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1193
            D+   V+ +EI   A+ AN   FI   P  + T VG+KG  LSGGQKQRIAIARAL++ P
Sbjct: 593  DDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNP 652

Query: 1194 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1253
            +ILLLDEATSALD E+E +VQEALD+  +GRT +VIAHRLSTI+NA+++ V   G++ E+
Sbjct: 653  KILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEY 712

Query: 1254 GTHQQLLAQ-KGIYFSMVSVQA 1274
            G H++LL++  GIY  +++ Q+
Sbjct: 713  GKHEELLSKPNGIYRKLMNKQS 734


>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
           sapiens]
          Length = 718

 Score =  318 bits (815), Expect = 2e-86
 Identities = 193/489 (39%), Positives = 284/489 (58%), Gaps = 11/489 (2%)

Query: 149 IRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIV 208
           +R+  F ++LRQ+I +FD N T +L +RLT D+ +        +    ++  T  AG +V
Sbjct: 210 MRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLV 268

Query: 209 GF-IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVI 267
              +   +LTL++M  +P L     +    L   S +     A+A  VA+EALG +RTV 
Sbjct: 269 SLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVR 328

Query: 268 AFGGQNKELERYQKHLE----NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
           AF  + +E ERY   LE     A+E+G   A+   +S  IAF  +        + G +LV
Sbjct: 329 AFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS-NIAFNCMVLG---TLFIGGSLV 384

Query: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
             ++ T G+ M+   +      S+   +           A   +F+ +  NP I      
Sbjct: 385 AGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444

Query: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
               + ++G++ F +V FSYP R   ++LK   L +  G+ VALVG SG GK+T   L++
Sbjct: 445 CVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504

Query: 444 RLYDPDEGTINIDGQDIRNFNVNYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEI 502
           R YDP  G + +DG+D+R  + ++LR +++G +SQEPVLF TTI ENI +G+   + +E+
Sbjct: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564

Query: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562
             A +EANA+EFI   P+ ++T+VGERG  LSGGQKQR+AIARAL++ P +L+LDEATSA
Sbjct: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624

Query: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEG 622
           LD ESE  VQ ALD+A  GRT +VIAHRLSTVR A  I    DG + E G+H EL+KK G
Sbjct: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684

Query: 623 VYFKLVNMQ 631
           +Y +L+  Q
Sbjct: 685 LYAELIRRQ 693



 Score =  310 bits (794), Expect = 6e-84
 Identities = 189/526 (35%), Positives = 291/526 (55%), Gaps = 10/526 (1%)

Query: 752  NIFSLIFLFLGIISFFTFFLQGFT--FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809
            N+ + + +  G+    TF   G+       GE +   +R   F ++LRQD+++FD   N 
Sbjct: 176  NLSTHLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANK 230

Query: 810  TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869
            TG L +RL TD  + + +    ++   ++   +   ++   +   +LTLLL+   P +  
Sbjct: 231  TGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMG 290

Query: 870  SGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRN 929
             G +    L   +++ ++++  A  +A EA+ N+RTV +   E++ E  Y  +L      
Sbjct: 291  VGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCR 350

Query: 930  SVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGH 989
            + +      +   +S         G    G  L+    +   D++    A      ++ +
Sbjct: 351  AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410

Query: 990  ASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV 1049
             S       +   + A +F      P I       +  ++  G++TF  V F+YP R   
Sbjct: 411  LSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470

Query: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109
             VL+  +L +  G+ +ALVG SG GK+TV  LLERFYDP AG V+LDG++ + L+  WLR
Sbjct: 471  EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLR 530

Query: 1110 AQL-GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1168
             Q+ G +SQEP+LF  +I ENI +G      S +E+ +AA+ AN H FI + P  Y T V
Sbjct: 531  GQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNTVV 588

Query: 1169 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1228
            G++GT LSGGQKQR+AIARALI+QP +L+LDEATSALD ESE+VVQEALD+A  GRT +V
Sbjct: 589  GERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLV 648

Query: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274
            IAHRLST++ A  IVV  +GRV E GTH++LL + G+Y  ++  QA
Sbjct: 649  IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694


>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score =  314 bits (805), Expect = 3e-85
 Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)

Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
           L  G   AA I+   +TL   R   ++R   F +++ QE  +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294

Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
            +S+ +   + +F +         +  F   W+L+LV     PI+ + + ++ K     S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354

Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
            +   A A+A   AEE + A++TV +F  + +E E Y + L+   ++  K+A +    + 
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414

Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
            + L +        +YG  LVIS + T GN +       +    +              G
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474

Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
           AA  +F+ ID  P +    +    PD ++G ++F +V F+Y +R + ++L+ ++  +  G
Sbjct: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532

Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
           +  ALVG SG GKS+ V +++  Y  + G + +DG+ I  ++  YL  +I +VSQEPVLF
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592

Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
           + +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQKQR+A
Sbjct: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652

Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
           +ARALVRNP +L+LDEATSALD ESE  +Q A+    +  T ++IAHRLSTV +A +I  
Sbjct: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712

Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
            + G +V+QG+H +L+ + G+Y KLV  Q  G Q
Sbjct: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746



 Score =  304 bits (779), Expect = 3e-82
 Identities = 196/542 (36%), Positives = 289/542 (53%), Gaps = 25/542 (4%)

Query: 743  DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
            D  V Q+  + FS   +I   L I S F   ++G  F      L  RLR+  F++++ Q+
Sbjct: 214  DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273

Query: 800  MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
             S+FD+  N TG L +RL +D   V       + +  +N   +   ++  F   WQL+L+
Sbjct: 274  TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331

Query: 860  LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
                 PII +   +  K     +K  +  L  A   A E I  ++TV S   E +   +Y
Sbjct: 332  TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391

Query: 920  VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972
            + KL   Y+ + ++A  Y       G+T  + Q  + +       +G +L+++G M   +
Sbjct: 392  LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444

Query: 973  VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031
            +I  +    V G   +    S      +   +A  +F   +RQP +    +  L PD  E
Sbjct: 445  LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501

Query: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
            G + F  V F Y TR +  VLQ +S  +  G+  ALVG SG GKS+ V +LE FY    G
Sbjct: 502  GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561

Query: 1092 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1151
             VLLDG+     + ++L   + +VSQEP+LF  SI +NI+YG     V  + +V AA+ A
Sbjct: 562  RVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKA 619

Query: 1152 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1211
            N H FI  L   Y T  G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE 
Sbjct: 620  NAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEY 679

Query: 1212 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271
            ++Q+A+    +  T ++IAHRLST+++A LIVV   GRV + GTHQQLLAQ G+Y  +V 
Sbjct: 680  LIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739

Query: 1272 VQ 1273
             Q
Sbjct: 740  RQ 741


>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score =  314 bits (805), Expect = 3e-85
 Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)

Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
           L  G   AA I+   +TL   R   ++R   F +++ QE  +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294

Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
            +S+ +   + +F +         +  F   W+L+LV     PI+ + + ++ K     S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354

Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
            +   A A+A   AEE + A++TV +F  + +E E Y + L+   ++  K+A +    + 
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414

Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
            + L +        +YG  LVIS + T GN +       +    +              G
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474

Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
           AA  +F+ ID  P +    +    PD ++G ++F +V F+Y +R + ++L+ ++  +  G
Sbjct: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532

Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
           +  ALVG SG GKS+ V +++  Y  + G + +DG+ I  ++  YL  +I +VSQEPVLF
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592

Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
           + +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQKQR+A
Sbjct: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652

Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
           +ARALVRNP +L+LDEATSALD ESE  +Q A+    +  T ++IAHRLSTV +A +I  
Sbjct: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712

Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
            + G +V+QG+H +L+ + G+Y KLV  Q  G Q
Sbjct: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746



 Score =  304 bits (779), Expect = 3e-82
 Identities = 196/542 (36%), Positives = 289/542 (53%), Gaps = 25/542 (4%)

Query: 743  DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
            D  V Q+  + FS   +I   L I S F   ++G  F      L  RLR+  F++++ Q+
Sbjct: 214  DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273

Query: 800  MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
             S+FD+  N TG L +RL +D   V       + +  +N   +   ++  F   WQL+L+
Sbjct: 274  TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331

Query: 860  LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
                 PII +   +  K     +K  +  L  A   A E I  ++TV S   E +   +Y
Sbjct: 332  TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391

Query: 920  VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972
            + KL   Y+ + ++A  Y       G+T  + Q  + +       +G +L+++G M   +
Sbjct: 392  LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444

Query: 973  VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031
            +I  +    V G   +    S      +   +A  +F   +RQP +    +  L PD  E
Sbjct: 445  LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501

Query: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
            G + F  V F Y TR +  VLQ +S  +  G+  ALVG SG GKS+ V +LE FY    G
Sbjct: 502  GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561

Query: 1092 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1151
             VLLDG+     + ++L   + +VSQEP+LF  SI +NI+YG     V  + +V AA+ A
Sbjct: 562  RVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKA 619

Query: 1152 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1211
            N H FI  L   Y T  G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE 
Sbjct: 620  NAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEY 679

Query: 1212 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271
            ++Q+A+    +  T ++IAHRLST+++A LIVV   GRV + GTHQQLLAQ G+Y  +V 
Sbjct: 680  LIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739

Query: 1272 VQ 1273
             Q
Sbjct: 740  RQ 741


>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 2 [Homo sapiens]
          Length = 723

 Score =  295 bits (755), Expect = 2e-79
 Identities = 176/514 (34%), Positives = 282/514 (54%), Gaps = 45/514 (8%)

Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
           L  G   AA I+   +TL   R   ++R   F +++ QE  +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294

Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
            +S+ +   + +F +         +  F   W+L+LV     PI+ + + ++ K     S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354

Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
            +   A A+A   AEE + A++TV +F  + +E E Y + L+   ++  K+A        
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA-------- 406

Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
                  A+Y    W GS          G+  +V+  ++ G                  G
Sbjct: 407 -------AAYMYYVW-GS----------GSVGSVYSGLMQGV-----------------G 431

Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
           AA  +F+ ID  P +    +    PD ++G ++F +V F+Y +R + ++L+ ++  +  G
Sbjct: 432 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 489

Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
           +  ALVG SG GKS+ V +++  Y  + G + +DG+ I  ++  YL  +I +VSQEPVLF
Sbjct: 490 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 549

Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
           + +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQKQR+A
Sbjct: 550 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 609

Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
           +ARALVRNP +L+LDEATSALD ESE  +Q A+    +  T ++IAHRLSTV +A +I  
Sbjct: 610 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 669

Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
            + G +V+QG+H +L+ + G+Y KLV  Q  G Q
Sbjct: 670 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 703



 Score =  290 bits (742), Expect = 6e-78
 Identities = 192/534 (35%), Positives = 276/534 (51%), Gaps = 52/534 (9%)

Query: 743  DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
            D  V Q+  + FS   +I   L I S F   ++G  F      L  RLR+  F++++ Q+
Sbjct: 214  DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273

Query: 800  MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
             S+FD+  N TG L +RL +D   V       + +  +N   +   ++  F   WQL+L+
Sbjct: 274  TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331

Query: 860  LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
                 PII +   +  K     +K  +  L  A   A E I  ++TV S   E +   +Y
Sbjct: 332  TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391

Query: 920  VEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSA 979
            + KL   Y+ + ++A           A+MY+ +                    V  V+S 
Sbjct: 392  LRKLQQVYKLNRKEA----------AAYMYYVWGS----------------GSVGSVYSG 425

Query: 980  IVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEV 1039
            ++ G  A                 A  +F   +RQP +    +  L PD  EG + F  V
Sbjct: 426  LMQGVGA-----------------AEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENV 466

Query: 1040 VFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQE 1099
             F Y TR +  VLQ +S  +  G+  ALVG SG GKS+ V +LE FY    G VLLDG+ 
Sbjct: 467  TFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKP 526

Query: 1100 AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET 1159
                + ++L   + +VSQEP+LF  SI +NI+YG     V  + +V AA+ AN H FI  
Sbjct: 527  ISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 584

Query: 1160 LPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK 1219
            L   Y T  G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE ++Q+A+  
Sbjct: 585  LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 644

Query: 1220 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
              +  T ++IAHRLST+++A LIVV   GRV + GTHQQLLAQ G+Y  +V  Q
Sbjct: 645  NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 698


>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
           sapiens]
          Length = 808

 Score =  258 bits (658), Expect = 3e-68
 Identities = 164/521 (31%), Positives = 267/521 (51%), Gaps = 5/521 (0%)

Query: 111 EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT 170
           +  TR     S L     V  ++    +    G     ++ + F A+LRQE  +F  N T
Sbjct: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQT 341

Query: 171 TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS 230
             + +R+T+D S +S+ + + + +F   +        +       LT+V +   P+L L 
Sbjct: 342 GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLL 401

Query: 231 AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
                K       +   + AK+  VA EAL A+ TV +F  +  E +++++ L+  K + 
Sbjct: 402 PKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461

Query: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
            K+A++  ++     +          + G  LV S   + GN +T     +    +V   
Sbjct: 462 QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVL 521

Query: 351 APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK 410
                    A G++  IF+ +D  P+          P  ++G ++F DV F+YP+R +V 
Sbjct: 522 LSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL--TPLHLEGLVQFQDVSFAYPNRPDVL 579

Query: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
           +L+GL   ++ G+  ALVG +G GKST   L+Q LY P  G + +DG+ +  +   YL  
Sbjct: 580 VLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHR 639

Query: 471 IIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
            +  V QEP +F  ++ ENI YG     TM+EI  A  ++ A+ FI  LPQ +DT V E 
Sbjct: 640 QVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699

Query: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA--REGRTTIVI 587
           G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD  S+ +V+  L ++  R  R+ ++I
Sbjct: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLI 759

Query: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
              LS V  AD I   E G I E G+H +LM+K+G Y+ +V
Sbjct: 760 TQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800



 Score =  238 bits (607), Expect = 3e-62
 Identities = 160/493 (32%), Positives = 256/493 (51%), Gaps = 13/493 (2%)

Query: 787  LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
            L+   F A+LRQ+  +F   +N TG + +R+  D + +  +    L+L    +     G+
Sbjct: 320  LQGEVFGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GL 374

Query: 847  IISFIYGW---QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENI 903
             +  I  W    LT++ L  +P++ +      K       + ++ L  + ++A EA+  +
Sbjct: 375  CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 434

Query: 904  RTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLI 963
             TV S   E      + EKL      + ++A  Y +    +         G    G  L+
Sbjct: 435  PTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLV 494

Query: 964  VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEE 1023
             +G +   +++      +    A+    S  P   KA  S+  +F   +R P        
Sbjct: 495  TSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL- 553

Query: 1024 GLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1083
             L P   EG + F +V F YP R +V VLQGL+  ++ G+  ALVG +G GKSTV  LL+
Sbjct: 554  -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612

Query: 1084 RFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1143
              Y P  G +LLDG+   +   ++L  Q+  V QEP +F  S+ ENIAYG   +  + +E
Sbjct: 613  NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQK-PTMEE 671

Query: 1144 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1203
            I +AA  +  H FI  LP  Y+T V + G+QLSGGQ+Q +A+ARALIR+P +L+LD+ATS
Sbjct: 672  ITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATS 731

Query: 1204 ALDTESEKVVQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1261
            ALD  S+  V++ L ++  R  R+ ++I   LS ++ AD I+  + G ++E GTHQQL+ 
Sbjct: 732  ALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLME 791

Query: 1262 QKGIYFSMVSVQA 1274
            +KG Y++MV   A
Sbjct: 792  KKGCYWAMVQAPA 804


>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
           isoform 1 [Homo sapiens]
          Length = 703

 Score =  243 bits (621), Expect = 7e-64
 Identities = 165/505 (32%), Positives = 273/505 (54%), Gaps = 29/505 (5%)

Query: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
           +T    R   +IR++ F ++LRQ++G+F    T ELN+RL+ D + +S  +     +  +
Sbjct: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273

Query: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
           ++       GF++      +LTL+ +   P    +  V+     ++L    D    A A+
Sbjct: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327

Query: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
           AG V  EA+G ++TV +FG +  E+ RY++ LE  +++  ++ +   + + +  +L    
Sbjct: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387

Query: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
             L    G   +   E T G+ +    S +I   SVG     +     D  +N  GAA  
Sbjct: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442

Query: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
           +F  +D  P + S       P +++G ++F DV F+YP+R +  +LKGL   ++ G+  A
Sbjct: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500

Query: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
           LVG +G GKST   L+Q LY P  G + +D + I  +   YL   +  V QEPVLFS ++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560

Query: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
             NI YG  +   D++  A + A+A +FI ++     T VGE+G+QL+ GQKQR+AIARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620

Query: 547 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606
           LVR+P++L+LDEATSALD + E  +Q     +R  RT +VIAHRL  V+ A  I   ++G
Sbjct: 621 LVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEG 678

Query: 607 VIVEQGSHSELMKKEGVYFKLVNMQ 631
            + +    ++L + + +Y +LV  +
Sbjct: 679 KLQKL---AQLQEGQDLYSRLVQQR 700



 Score =  224 bits (572), Expect = 3e-58
 Identities = 176/575 (30%), Positives = 291/575 (50%), Gaps = 53/575 (9%)

Query: 699  KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
            ++LKL++ + P  V      V A+    L P +S     +I I G   D       + F+
Sbjct: 140  RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190

Query: 756  LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
                F+ + SF +    G   G     ++R   R+R   F ++LRQD+ +F + K  TG 
Sbjct: 191  SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248

Query: 813  LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
            L++RL++D   +         ++ +++        +  +YG+      +LTLL L  +P 
Sbjct: 249  LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302

Query: 867  IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
               +  V         +  +  +  AG++  EA+  ++TV S   E      Y E     
Sbjct: 303  TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362

Query: 922  -KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI 980
             +LY  +R  +++A +Y +   +    +      C   G   + +G +    ++   S +
Sbjct: 363  RQLY--WRRDLERA-LYLLVRRVLHLGVQMLMLSC---GLQQMQDGELTQGSLL---SFM 413

Query: 981  VFGAVALGHASSFAPDYAK--AKLSAAH-LFMLFERQPLIDSYSEEGLKPDKFEGNITFN 1037
            ++      +  +    Y    + + AA  +F   +RQP + S     L P   +G + F 
Sbjct: 414  IYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQ 471

Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1097
            +V F YP R + PVL+GL+  ++ G+  ALVG +G GKSTV  LL+  Y P  G VLLD 
Sbjct: 472  DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDE 531

Query: 1098 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1157
            +   +    +L +Q+  V QEP+LF  S+  NIAYG  S     D++++AA+AA+   FI
Sbjct: 532  KPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHADDFI 589

Query: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1217
            + + H   T VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E+ +Q+  
Sbjct: 590  QEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW- 648

Query: 1218 DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE 1252
              +R  RT +VIAHRL  +Q A  I+V Q G++++
Sbjct: 649  -NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682


>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
           sapiens]
          Length = 842

 Score =  236 bits (601), Expect = 1e-61
 Identities = 175/490 (35%), Positives = 252/490 (51%), Gaps = 43/490 (8%)

Query: 176 RLTDDISKISE-GIGDKVGMF----FQAVATFFAGFIVG------FIRGWKLTLVIMAIS 224
           R T ++ +I++ G     G+     F  + T  A  I+G      F   W   +V + +S
Sbjct: 364 RRTGEVLRIADRGTSSVTGLLSYLVFNVIPTL-ADIIIGIIYFSMFFNAWFGLIVFLCMS 422

Query: 225 PILGLSAAV--W-AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
             L L+  V  W  K   A + +E A  A+A     ++L    TV  +  ++ E+ERY++
Sbjct: 423 LYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETVKYYNAESYEVERYRE 478

Query: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
            +   + +  K + S  +      L+I           +  V  ++  +G+       +L
Sbjct: 479 AIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDY------VL 532

Query: 342 IGAFSVGQAAPCIDAFANARGAAYVIF--DIIDNNPKIDSFSERGHKPDSI--------K 391
            G + +    P      N  G  Y +   + ID     D   E     D          K
Sbjct: 533 FGTYIIQLYMPL-----NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK 587

Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
           G +EF +VHFSY        L+ ++  V  GQT+ALVG SG GKST ++L+ R YD   G
Sbjct: 588 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645

Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
            I IDGQDI       LR  IGVV Q+ VLF+ TIA+NI YGR     DE++ A + A  
Sbjct: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705

Query: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
           ++ IM  P+ + T VGERG +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E  +
Sbjct: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765

Query: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
           QA+L K    RTTIV+AHRLSTV NAD I   +DG IVE+G H  L+ + GVY  +  +Q
Sbjct: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825

Query: 632 TSGSQIQSEE 641
             G +  SE+
Sbjct: 826 -QGQEETSED 834



 Score =  224 bits (570), Expect = 5e-58
 Identities = 163/524 (31%), Positives = 266/524 (50%), Gaps = 32/524 (6%)

Query: 767  FTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQG 826
            F   L+ F + +  +  +RR+  + F  +    + W    +  TG +        + V G
Sbjct: 325  FVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRR--TGEVLRIADRGTSSVTG 382

Query: 827  ATGTRLALIAQNIANLGTGII-ISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD 885
                 +  +   +A++  GII  S  +     L++   + +     IV  +      +  
Sbjct: 383  LLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAM 442

Query: 886  KKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQ 945
              +  A    A +++ N  TV    +    ES  VE+    YR ++ K    G+ +  S 
Sbjct: 443  NTQENATRARAVDSLLNFETV----KYYNAESYEVER----YREAIIKYQ--GLEWKSSA 492

Query: 946  AFMYFSYAGCFRFG----------AYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAP 995
            + +  +       G          AY +    ++  D +L  + I+   + L    ++  
Sbjct: 493  SLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552

Query: 996  DYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE-GNITFNEVVFNYPTRANVPVLQG 1054
                  +   ++F L + +  +      G  P +F+ G I F  V F+Y        LQ 
Sbjct: 553  MIQTNFIDMENMFDLLKEETEVKDLPGAG--PLRFQKGRIEFENVHFSYADGRET--LQD 608

Query: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1114
            +S  V  GQTLALVG SG GKST+++LL RFYD  +G + +DGQ+  ++    LR+ +G+
Sbjct: 609  VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGV 668

Query: 1115 VSQEPILFDCSIAENIAYGDNSRVVS-QDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1173
            V Q+ +LF+ +IA+NI YG   RV +  DE+ +AA+AA IH  I   P  Y T+VG++G 
Sbjct: 669  VPQDTVLFNDTIADNIRYG---RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725

Query: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1233
            +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E+ +Q +L K    RT IV+AHRL
Sbjct: 726  KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 785

Query: 1234 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
            ST+ NAD I+V ++G + E G H+ LL++ G+Y  M  +Q G +
Sbjct: 786  STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQE 829


>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
            [Homo sapiens]
          Length = 1437

 Score =  235 bits (600), Expect = 2e-61
 Identities = 281/1185 (23%), Positives = 504/1185 (42%), Gaps = 169/1185 (14%)

Query: 198  AVATFFAGFIVGFIRGWKLTLVIMAISPILGLS-------AAVWAKILSA-FSDKELAAY 249
            AV +  AG  V  I G    ++I+  +  LG +       A ++A  L+A F  K +AA 
Sbjct: 292  AVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAAT 351

Query: 250  AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
             +      E L  I+ +  +       +  QK  E  + I  K     +I++G+A +++ 
Sbjct: 352  DERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVV 411

Query: 310  ASYALAF----WYGSTLVISKEYTIG---NAMTVFFSILIGAFSV---GQAAPCIDAFA- 358
             +  + F      G  L  ++ +T+    N+MT  F++ +  FSV    +A+  +D F  
Sbjct: 412  IASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMT--FALKVTPFSVKSLSEASVAVDRFKS 469

Query: 359  -----------NARGAAYVIFDI-------------IDNNPKI------DSFSERGHKPD 388
                       N   + ++  ++             I N+PK+      D  + RG K  
Sbjct: 470  LFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEK 529

Query: 389  --------------SIKGNLEFNDVHFSYPSRANVK-----------ILKGLNLKVQSGQ 423
                            KG+L  +      P     K            L  ++L++Q G+
Sbjct: 530  VRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGK 589

Query: 424  TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS 483
             V + GS G GK++ +  I       EG+I I G                 V+Q+  + +
Sbjct: 590  LVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILN 636

Query: 484  TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 543
             T+ +NI +G+     +     +        +  LP    T +GERGA LSGGQ+QRI++
Sbjct: 637  ATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL 695

Query: 544  ARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
            ARAL  +  I +LD+  SALD      +  +A+ K  + +T + + H+L  + + D +  
Sbjct: 696  ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIF 755

Query: 603  FEDGVIVEQGSHSELMKKEGVYFKLVNM----QTSGSQIQSEEFELNDEKAATRMAPNGW 658
             ++G I E+G+H ELM   G Y  + N     +T   +I S++     +K +    P   
Sbjct: 756  MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTG 815

Query: 659  ---KSRLFRHSTQKNLKNSQMCQKSLDVETDG--LEANVPPVSFLKVLKLN--------- 704
               K +  +    + ++  +  Q S+     G  ++A   P++FL ++ L          
Sbjct: 816  SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875

Query: 705  KTEWPYFVV--GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLG 762
             T W  + +  G+       G + + S             D+   Q   +I++L    + 
Sbjct: 876  STWWLSYWIKQGSGNTTVTRGNETSVSDSMK---------DNPHMQYYASIYALSMAVML 926

Query: 763  IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
            I+      ++G  F K     + RL    F+ +LR  M +FD     TG +  R + D  
Sbjct: 927  ILKA----IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMD 980

Query: 823  QVQGATGTRLALIAQNIANLGTGI-IISFIYGWQLTLLLLAVVPIIAVSGIVEM--KLLA 879
            +V      +  +  QN+  +   + +I+ ++ W     L+AV P++ +  ++ +  ++L 
Sbjct: 981  EVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHIVSRVLI 1036

Query: 880  GNAKR-DKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
               KR D           T +I+ + T+ +  + ++F   Y E L         +A  + 
Sbjct: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL------DDNQAPFFL 1090

Query: 939  ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI--VFGAVALGHASSFAPD 996
             T ++    +           A +   G M    ++L+   I   +  +A+ +A      
Sbjct: 1091 FTCAMRWLAVRLDLISI----ALITTTGLM----IVLMHGQIPPAYAGLAISYAVQLTGL 1142

Query: 997  YAKAKLSAAHLFMLFERQPLIDSY------------SEEGLKPD-KFEGNITFNEVVFNY 1043
            +      A+     F     I+ Y              +   PD   EG +TF      Y
Sbjct: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202

Query: 1044 PTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKK 1102
              R N+P VL+ +S  +K  + + +VG +G GKS++   L R  +   G + +DG     
Sbjct: 1203 --RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD 1260

Query: 1103 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1162
            + +  LR++L I+ QEP+LF  ++  N+   D     ++D+I  A +  ++   I  LP 
Sbjct: 1261 IGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQLPL 1317

Query: 1163 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKARE 1222
            K E+ V + G   S G++Q + IARAL+R  +IL+LDEAT+A+DTE++ ++QE + +A  
Sbjct: 1318 KLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1377

Query: 1223 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1267
              T + IAHRL T+  +D I+V   G+V E  T   LL+     F
Sbjct: 1378 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422



 Score =  147 bits (371), Expect = 6e-35
 Identities = 141/534 (26%), Positives = 248/534 (46%), Gaps = 43/534 (8%)

Query: 113  MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
            M  YA  Y+   A +L+   I+   +     R   ++  + F  ILR  + +FD   T  
Sbjct: 911  MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970

Query: 173  LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRG---WKLTLV--IMAISPIL 227
            +  R + D+ ++   +  +  MF Q V   F  F VG I G   W L  V  ++ +  +L
Sbjct: 971  ILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVFPWFLVAVGPLVILFSVL 1028

Query: 228  GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLEN-- 285
             + + V  + L    +   + +    +    ++  + T+ A+    + L RYQ+ L++  
Sbjct: 1029 HIVSRVLIRELKRLDNITQSPFL---SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ 1085

Query: 286  ---------AKEIGIKK---AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNA 333
                      + + ++    +I+   + G+  +L++     A+   + L IS  Y +   
Sbjct: 1086 APFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAY---AGLAIS--YAV--Q 1138

Query: 334  MTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKG 392
            +T  F      F+V  A+     F +     + I  +    P       +   PD   +G
Sbjct: 1139 LTGLFQ-----FTVRLASETEARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEG 1191

Query: 393  NLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
             + F +    Y  R N+  +LK ++  ++  + + +VG +G GKS+    + RL +   G
Sbjct: 1192 EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249

Query: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
             I IDG  I +  +  LR  + ++ QEPVLFS T+  N+       T D+I  A++  + 
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-DPFNQYTEDQIWDALERTHM 1308

Query: 512  YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
             E I +LP K ++ V E G   S G++Q + IARAL+R+ KIL+LDEAT+A+DTE++  +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368

Query: 572  QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
            Q  + +A    T + IAHRL TV  +D I     G +VE  + S L+  +   F
Sbjct: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422


>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
           isoform 2 [Homo sapiens]
          Length = 653

 Score =  223 bits (568), Expect = 9e-58
 Identities = 147/442 (33%), Positives = 240/442 (54%), Gaps = 24/442 (5%)

Query: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
           +T    R   +IR++ F ++LRQ++G+F    T ELN+RL+ D + +S  +     +  +
Sbjct: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273

Query: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
           ++       GF++      +LTL+ +   P    +  V+     ++L    D    A A+
Sbjct: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327

Query: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
           AG V  EA+G ++TV +FG +  E+ RY++ LE  +++  ++ +   + + +  +L    
Sbjct: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387

Query: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
             L    G   +   E T G+ +    S +I   SVG     +     D  +N  GAA  
Sbjct: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442

Query: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
           +F  +D  P + S       P +++G ++F DV F+YP+R +  +LKGL   ++ G+  A
Sbjct: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500

Query: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
           LVG +G GKST   L+Q LY P  G + +D + I  +   YL   +  V QEPVLFS ++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560

Query: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
             NI YG  +   D++  A + A+A +FI ++     T VGE+G+QL+ GQKQR+AIARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620

Query: 547 LVRNPKILLLDEATSALDTESE 568
           LVR+P++L+LDEATSALD + E
Sbjct: 621 LVRDPRVLILDEATSALDVQCE 642



 Score =  198 bits (503), Expect = 3e-50
 Identities = 160/534 (29%), Positives = 265/534 (49%), Gaps = 51/534 (9%)

Query: 699  KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
            ++LKL++ + P  V      V A+    L P +S     +I I G   D       + F+
Sbjct: 140  RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190

Query: 756  LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
                F+ + SF +    G   G     ++R   R+R   F ++LRQD+ +F + K  TG 
Sbjct: 191  SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248

Query: 813  LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
            L++RL++D   +         ++ +++        +  +YG+      +LTLL L  +P 
Sbjct: 249  LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302

Query: 867  IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
               +  V         +  +  +  AG++  EA+  ++TV S   E      Y E     
Sbjct: 303  TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362

Query: 922  -KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI 980
             +LY  +R  +++A +Y +   +    +      C   G   + +G +    ++   S +
Sbjct: 363  RQLY--WRRDLERA-LYLLVRRVLHLGVQMLMLSC---GLQQMQDGELTQGSLL---SFM 413

Query: 981  VFGAVALGHASSFAPDYAK--AKLSAAH-LFMLFERQPLIDSYSEEGLKPDKFEGNITFN 1037
            ++      +  +    Y    + + AA  +F   +RQP + S     L P   +G + F 
Sbjct: 414  IYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQ 471

Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1097
            +V F YP R + PVL+GL+  ++ G+  ALVG +G GKSTV  LL+  Y P  G VLLD 
Sbjct: 472  DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDE 531

Query: 1098 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1157
            +   +    +L +Q+  V QEP+LF  S+  NIAYG  S     D++++AA+AA+   FI
Sbjct: 532  KPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHADDFI 589

Query: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1211
            + + H   T VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E+
Sbjct: 590  QEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643


>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2B [Homo sapiens]
          Length = 1549

 Score =  220 bits (560), Expect = 8e-57
 Identities = 226/929 (24%), Positives = 416/929 (44%), Gaps = 119/929 (12%)

Query: 400  HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
            +FS+ S   +  L  +++++ +GQ   +VG  GCGKS+ +  I       EG ++     
Sbjct: 678  YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735

Query: 458  QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
            +   +F     R    V   +Q+P L + T+ ENI +G  +    +  KAV +A + +  
Sbjct: 736  ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793

Query: 515  IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
            I  LP    T +GERG  LSGGQ+QRI +ARAL +N  I+ LD+  SALD   S+  +Q 
Sbjct: 794  IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853

Query: 574  ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
             + K  +   RT +++ H+L  + +AD I   +DG ++ +G+  ++  K+    +L    
Sbjct: 854  GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910

Query: 632  TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
             +    Q +E E + E   T +     +  ++    +  +++    ++  + E D    N
Sbjct: 911  KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966

Query: 692  VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
            +  V  L+     KT W Y        + +GG      +IFS+      I+AI       
Sbjct: 967  MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018

Query: 739  --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
                     G  D        +I     +FL +++  T    G T  K        L   
Sbjct: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1071

Query: 791  AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
                ++   + +FD      G +  R + D   + Q    T  +L    +  L    +IS
Sbjct: 1072 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1129

Query: 850  FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
            +       + L+A++P+      ++       A +D +EL+ + ++      +E  E + 
Sbjct: 1130 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1183

Query: 905  TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
            T+ +   E +F+   +E                 +T + + A+++ S A  +        
Sbjct: 1184 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1226

Query: 959  GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
            GA +++        +  +  +   G V LG  +A +          + A L +       
Sbjct: 1227 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281

Query: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
            ++S+    ++ + +EG +  ++V  ++P    +              PVL+ +   +K G
Sbjct: 1282 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1339

Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
            Q + + G +G GKS++     R  D   G +++DG +  KL +  LR++L I+ Q+PILF
Sbjct: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1399

Query: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
              SI  N+   D     + D +  A + A +   +++LP   +  V + G   S GQ+Q 
Sbjct: 1400 SGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQL 1456

Query: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
              +ARA +R+  IL++DEAT+++D  +E ++Q+ +  A   RT + IAHR+ TI  ADL+
Sbjct: 1457 FCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLV 1516

Query: 1243 VVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1270
            +V + G + E+ T + LLAQ+ G++ S V
Sbjct: 1517 IVMKRGNILEYDTPESLLAQENGVFASFV 1545



 Score =  122 bits (307), Expect = 2e-27
 Identities = 79/240 (32%), Positives = 131/240 (54%), Gaps = 5/240 (2%)

Query: 391  KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
            +G ++ +D+   Y +  N+K +LK +   ++ GQ V + G +G GKS+      R+ D  
Sbjct: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366

Query: 450  EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
            +G I IDG DI    ++ LR  + ++ Q+P+LFS +I  N+       T D + +A++ A
Sbjct: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425

Query: 510  NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
                 +  LP   D +V E G   S GQ+Q   +ARA VR   IL++DEAT+++D  +E 
Sbjct: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485

Query: 570  EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLV 628
             +Q  +  A   RT + IAHR+ T+  AD++   + G I+E  +   L+ +E GV+   V
Sbjct: 1486 ILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545



 Score =  106 bits (264), Expect = 2e-22
 Identities = 71/248 (28%), Positives = 127/248 (51%), Gaps = 13/248 (5%)

Query: 1017 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
            +DSY  S   L+P + E +I        +   + +  L  + + +  GQ   +VG  GCG
Sbjct: 652  LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710

Query: 1075 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ----LGIVSQEPILFDCSIAENI 1130
            KS+++  +      L G V        + + +  R++    +   +Q+P L + ++ ENI
Sbjct: 711  KSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENI 770

Query: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
             +G      ++    +   A ++ P I+ LP   +T +G++G  LSGGQ+QRI +ARAL 
Sbjct: 771  TFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827

Query: 1191 RQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVVFQN 1247
            +   I+ LD+  SALD   S+ ++QE + K    + RT +++ H+L  + +AD I+  ++
Sbjct: 828  QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887

Query: 1248 GRVKEHGT 1255
            G V   GT
Sbjct: 888  GSVLREGT 895


>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
            [Homo sapiens]
          Length = 1531

 Score =  216 bits (551), Expect = 9e-56
 Identities = 214/926 (23%), Positives = 395/926 (42%), Gaps = 63/926 (6%)

Query: 378  DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
            DS   R  K      ++   +  F++ +R++   L G+   +  G  VA+VG  GCGKS+
Sbjct: 628  DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686

Query: 438  TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
             +  +    D  EG + I G              +  V Q+  + + ++ ENI +G   +
Sbjct: 687  LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGC-QL 732

Query: 498  TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
                 +  ++       +  LP    T +GE+G  LSGGQKQR+++ARA+  N  I L D
Sbjct: 733  EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792

Query: 558  EATSALDTESEAEVQAALDKAR---EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
            +  SA+D      +   +   +   + +T I++ H +S +   DVI     G I E GS+
Sbjct: 793  DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852

Query: 615  SELMKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKN 673
             EL+ ++G + + +    S  Q Q +EE  +       + A       L   S  K L+ 
Sbjct: 853  QELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR 912

Query: 674  SQMCQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGT 715
                  S   +         +  +A        K+++ +K +         W Y   +G 
Sbjct: 913  QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL 972

Query: 716  VCAIANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFL 771
              +  +  L      S + S         D  V   Q+   +   ++  LGI      F 
Sbjct: 973  FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFG 1032

Query: 772  QGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTR 831
                    G + +R L      ++LR  MS+F+  +  +G L  R + +   V       
Sbjct: 1033 YSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEV 1090

Query: 832  LALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
            + +   ++ N+    I+  +     T +   ++P + +      +    ++ R  K LE+
Sbjct: 1091 IKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLES 1145

Query: 892  AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFM 948
              +    +  N  T++ ++  R FE    E+        V   QKA+   I  +   A  
Sbjct: 1146 VSRSPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVR 1202

Query: 949  YFSYAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAA 1005
                  C    A L  +++ H     ++ L  S  +     L      + +     ++  
Sbjct: 1203 LECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE 1262

Query: 1006 HLFMLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1063
             L    E +       +E   P  +   G + F      Y    +  VL+ +++ +  G+
Sbjct: 1263 RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGE 1321

Query: 1064 TLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1123
             + +VG +G GKS++   L R  +   G +++DG    K+ +  LR ++ I+ Q+P+LF 
Sbjct: 1322 KVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFS 1381

Query: 1124 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI 1183
             S+  N+   D     S +E+ ++ + A++  F+  LP K +    + G  LS GQ+Q +
Sbjct: 1382 GSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1438

Query: 1184 AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1243
             +ARAL+R+ +IL+LDEAT+A+D E++ ++Q  +    E  T + IAHRL+TI +   ++
Sbjct: 1439 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI 1498

Query: 1244 VFQNGRVKEHGTHQQLLAQKGIYFSM 1269
            V   G ++E+G    LL Q+G+++SM
Sbjct: 1499 VLDKGEIQEYGAPSDLLQQRGLFYSM 1524



 Score =  124 bits (311), Expect = 6e-28
 Identities = 81/270 (30%), Positives = 132/270 (48%), Gaps = 30/270 (11%)

Query: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
            S E L+PD  E           +IT     F +  R++ P L G++  + +G  +A+VG 
Sbjct: 621  SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679

Query: 1071 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1130
             GCGKS+++  L    D + G V + G  A      W++       +E ILF C + E  
Sbjct: 680  VGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDS---LRENILFGCQLEEPY 736

Query: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
                           S  +A  + P +E LP    T +G+KG  LSGGQKQR+++ARA+ 
Sbjct: 737  YR-------------SVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783

Query: 1191 RQPQILLLDEATSALDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNADLIVVFQN 1247
                I L D+  SA+D    K + E +   +   + +T I++ H +S +   D+I+V   
Sbjct: 784  SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843

Query: 1248 GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
            G++ E G++Q+LLA+ G +   +   A T+
Sbjct: 844  GKISEMGSYQELLARDGAFAEFLRTYASTE 873


>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A-delta-14 [Homo sapiens]
          Length = 1513

 Score =  214 bits (544), Expect = 6e-55
 Identities = 225/926 (24%), Positives = 411/926 (44%), Gaps = 118/926 (12%)

Query: 400  HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
            +FS+ S   +  L  +++++ +GQ   +VG  GCGKS+ +  I       EG ++     
Sbjct: 642  YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 699

Query: 458  QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
            +   +F     R    V   +Q+P L + T+ ENI +G  +    +  KAV +A + +  
Sbjct: 700  ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 757

Query: 515  IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
            I  LP    T +GERG  LSGGQ+QRI +ARAL +N  I+ LD+  SALD   S+  +Q 
Sbjct: 758  IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 817

Query: 574  ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
             + K  +   RT +++ H+L  + +AD I   +DG ++ +G+  ++  K+    +L    
Sbjct: 818  GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 874

Query: 632  TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
             +    Q +E E + E   T +     +  ++    +  +++    ++  + E D    N
Sbjct: 875  KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 930

Query: 692  VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
            +  V  L+     KT W Y        + +GG      +IFS+      I+AI       
Sbjct: 931  MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982

Query: 739  --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
                     G  D        +I     +FL +++  T    G T  K        L   
Sbjct: 983  TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1035

Query: 791  AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
                ++   + +FD      G +  R + D   + Q    T  +L    +  L    +IS
Sbjct: 1036 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1093

Query: 850  FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
            +       + L+A++P+      ++       A +D +EL+ + ++      +E  E + 
Sbjct: 1094 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1147

Query: 905  TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
            T+ +   E +F+   +E                 +T + + A+++ S A  +        
Sbjct: 1148 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1190

Query: 959  GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
            GA +++        +  +  +   G V LG  +A +          + A L +       
Sbjct: 1191 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1245

Query: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
            ++S+    ++ + +EG +  ++V  ++P    +              PVL+ +   +K G
Sbjct: 1246 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1303

Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
            Q + + G +G GKS++     R  D   G +++DG +  KL +  LR++L I+ Q+PILF
Sbjct: 1304 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1363

Query: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
              SI  N+   D     + D +  A + A +   +++LP   +  V + G   S GQ+Q 
Sbjct: 1364 SGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQL 1420

Query: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
              +ARA +R+  IL++DEAT+++D  +E ++Q+ +  A   RT + IAHR+S+I +A L+
Sbjct: 1421 FCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLV 1480

Query: 1243 VVFQNGRVKEHGTHQQLLAQKGIYFS 1268
            +VF  G + E  T   LLA K   FS
Sbjct: 1481 LVFSEGILVECDTVPNLLAHKNGLFS 1506



 Score =  125 bits (314), Expect = 3e-28
 Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)

Query: 391  KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
            +G ++ +D+   Y +  N+K +LK +   ++ GQ V + G +G GKS+      R+ D  
Sbjct: 1273 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1330

Query: 450  EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
            +G I IDG DI    ++ LR  + ++ Q+P+LFS +I  N+       T D + +A++ A
Sbjct: 1331 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1389

Query: 510  NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
                 +  LP   D +V E G   S GQ+Q   +ARA VR   IL++DEAT+++D  +E 
Sbjct: 1390 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1449

Query: 570  EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
             +Q  +  A   RT + IAHR+S++ +A ++  F +G++VE  +   L+  K G++  LV
Sbjct: 1450 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509


>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A [Homo sapiens]
          Length = 1549

 Score =  214 bits (544), Expect = 6e-55
 Identities = 225/926 (24%), Positives = 411/926 (44%), Gaps = 118/926 (12%)

Query: 400  HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
            +FS+ S   +  L  +++++ +GQ   +VG  GCGKS+ +  I       EG ++     
Sbjct: 678  YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735

Query: 458  QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
            +   +F     R    V   +Q+P L + T+ ENI +G  +    +  KAV +A + +  
Sbjct: 736  ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793

Query: 515  IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
            I  LP    T +GERG  LSGGQ+QRI +ARAL +N  I+ LD+  SALD   S+  +Q 
Sbjct: 794  IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853

Query: 574  ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
             + K  +   RT +++ H+L  + +AD I   +DG ++ +G+  ++  K+    +L    
Sbjct: 854  GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910

Query: 632  TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
             +    Q +E E + E   T +     +  ++    +  +++    ++  + E D    N
Sbjct: 911  KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966

Query: 692  VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
            +  V  L+     KT W Y        + +GG      +IFS+      I+AI       
Sbjct: 967  MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018

Query: 739  --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
                     G  D        +I     +FL +++  T    G T  K        L   
Sbjct: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1071

Query: 791  AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
                ++   + +FD      G +  R + D   + Q    T  +L    +  L    +IS
Sbjct: 1072 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1129

Query: 850  FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
            +       + L+A++P+      ++       A +D +EL+ + ++      +E  E + 
Sbjct: 1130 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1183

Query: 905  TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
            T+ +   E +F+   +E                 +T + + A+++ S A  +        
Sbjct: 1184 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1226

Query: 959  GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
            GA +++        +  +  +   G V LG  +A +          + A L +       
Sbjct: 1227 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281

Query: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
            ++S+    ++ + +EG +  ++V  ++P    +              PVL+ +   +K G
Sbjct: 1282 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1339

Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
            Q + + G +G GKS++     R  D   G +++DG +  KL +  LR++L I+ Q+PILF
Sbjct: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1399

Query: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
              SI  N+   D     + D +  A + A +   +++LP   +  V + G   S GQ+Q 
Sbjct: 1400 SGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQL 1456

Query: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
              +ARA +R+  IL++DEAT+++D  +E ++Q+ +  A   RT + IAHR+S+I +A L+
Sbjct: 1457 FCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLV 1516

Query: 1243 VVFQNGRVKEHGTHQQLLAQKGIYFS 1268
            +VF  G + E  T   LLA K   FS
Sbjct: 1517 LVFSEGILVECDTVPNLLAHKNGLFS 1542



 Score =  125 bits (314), Expect = 3e-28
 Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)

Query: 391  KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
            +G ++ +D+   Y +  N+K +LK +   ++ GQ V + G +G GKS+      R+ D  
Sbjct: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366

Query: 450  EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
            +G I IDG DI    ++ LR  + ++ Q+P+LFS +I  N+       T D + +A++ A
Sbjct: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425

Query: 510  NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
                 +  LP   D +V E G   S GQ+Q   +ARA VR   IL++DEAT+++D  +E 
Sbjct: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485

Query: 570  EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
             +Q  +  A   RT + IAHR+S++ +A ++  F +G++VE  +   L+  K G++  LV
Sbjct: 1486 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545



 Score =  106 bits (264), Expect = 2e-22
 Identities = 71/248 (28%), Positives = 127/248 (51%), Gaps = 13/248 (5%)

Query: 1017 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
            +DSY  S   L+P + E +I        +   + +  L  + + +  GQ   +VG  GCG
Sbjct: 652  LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710

Query: 1075 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ----LGIVSQEPILFDCSIAENI 1130
            KS+++  +      L G V        + + +  R++    +   +Q+P L + ++ ENI
Sbjct: 711  KSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENI 770

Query: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
             +G      ++    +   A ++ P I+ LP   +T +G++G  LSGGQ+QRI +ARAL 
Sbjct: 771  TFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827

Query: 1191 RQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVVFQN 1247
            +   I+ LD+  SALD   S+ ++QE + K    + RT +++ H+L  + +AD I+  ++
Sbjct: 828  QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887

Query: 1248 GRVKEHGT 1255
            G V   GT
Sbjct: 888  GSVLREGT 895


>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
            [Homo sapiens]
          Length = 1325

 Score =  210 bits (535), Expect = 6e-54
 Identities = 226/954 (23%), Positives = 434/954 (45%), Gaps = 132/954 (13%)

Query: 377  IDSFSERGHK-PDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
            +D  S+R  + P   K  +   D    +   +    L+GL+  V+ G+ +A+VG  G GK
Sbjct: 392  LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451

Query: 436  STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
            S+ +  +     P  G +++ G+             I  VSQ+P +FS T+  NI +G+ 
Sbjct: 452  SSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTLRSNILFGK- 497

Query: 496  NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
                +  +K +K     + +  L     T++G+RG  LSGGQK R+ +ARA+ ++  I L
Sbjct: 498  KYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557

Query: 556  LDEATSALDTE-SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
            LD+  SA+D E S    +  + +    + TI++ H+L  ++ A  I   +DG +V++G++
Sbjct: 558  LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTY 617

Query: 615  SELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNS 674
            +E + K G+ F        GS ++ +  E   E+      P   ++R F  S+  + ++S
Sbjct: 618  TEFL-KSGIDF--------GSLLKKDNEE--SEQPPVPGTPT-LRNRTFSESSVWSQQSS 665

Query: 675  QMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--------------WPYFVVGTVCAIA 720
            +   K   +E+   E NVP    + + + N++E                +++V     + 
Sbjct: 666  RPSLKDGALESQDTE-NVP----VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720

Query: 721  NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSL----------IFLFLGIISFFTFF 770
            N   Q A+      ++  +     A KQ   N+             +  +LGI S  T  
Sbjct: 721  NTAAQVAY------VLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT-- 772

Query: 771  LQGFTFGKAGEIL--------TRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
            +    FG A  +L        ++ L +  F+++L+  + +FD  +N  G +  R + D  
Sbjct: 773  VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKDIG 830

Query: 823  QVQGATG-TRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
             +      T L  I   +  +G   +   +  W    + + +VP+  +   +    L   
Sbjct: 831  HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPW----IAIPLVPLGIIFIFLRRYFL--E 884

Query: 882  AKRDKKELEAAGKI-----ATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHI 936
              RD K LE+  +       + +++ + T+ +   E +      ++L+  +++   +A  
Sbjct: 885  TSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEER-----CQELFDAHQDLHSEAWF 939

Query: 937  YGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPD 996
              +T   S+ F     A C  F              +I+ F +++            A  
Sbjct: 940  LFLT--TSRWFAVRLDAICAMF-------------VIIVAFGSLILAKTLDAGQVGLALS 984

Query: 997  YAK---------AKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE----------GNITFN 1037
            YA           + SA    M+   + +I+    E   P +++          G I F+
Sbjct: 985  YALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFD 1044

Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1097
             V F Y     + VL+ L+  +K  + + +VG +G GKS+++  L R  +P  G + +D 
Sbjct: 1045 NVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDK 1102

Query: 1098 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1157
                ++ +  LR ++ I+ QEP+LF  ++ +N+   D     + +E+ +A +   +   I
Sbjct: 1103 ILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWNALQEVQLKETI 1159

Query: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1217
            E LP K +T + + G+  S GQ+Q + +ARA++R+ QIL++DEAT+ +D  +++++Q+ +
Sbjct: 1160 EDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKI 1219

Query: 1218 DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1270
             +     T + IAHRL+TI ++D I+V  +GR+KE+     LL  K  +++ MV
Sbjct: 1220 REKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273



 Score =  129 bits (324), Expect = 2e-29
 Identities = 129/542 (23%), Positives = 250/542 (46%), Gaps = 40/542 (7%)

Query: 106  GKILEE-EMTRYAYYYSGLGAGVLVAAYIQ--VSFWTLAAGRQIRKIRQKFFHAILRQEI 162
            G + E+ ++  Y   YSGL    ++    +  + F+ L    Q   +  K F +IL+  +
Sbjct: 753  GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT--LHNKMFESILKAPV 810

Query: 163  GWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMA 222
             +FD N    +  R + DI  + +            +   F  FI   ++   +  V +A
Sbjct: 811  LFFDRNPIGRILNRFSKDIGHLDD-----------LLPLTFLDFIQTLLQVVGVVSVAVA 859

Query: 223  ISPILGLSAAVWAKIL---------SAFSDKELAAYAKAGAVAE--EALGAIRTVIAFGG 271
            + P + +       I          ++   K L +  ++   +    +L  + T+ A+  
Sbjct: 860  VIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKA 919

Query: 272  QNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIG 331
            + +  E +  H +   E      ++ +    +    I A + +   +GS L+++K    G
Sbjct: 920  EERCQELFDAHQDLHSEAWFL-FLTTSRWFAVRLDAICAMFVIIVAFGS-LILAKTLDAG 977

Query: 332  NAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIID-NNPKIDSFSERGHKPDSI 390
                V  ++      +G    C+   A        +  +I+  + + ++  E   +P   
Sbjct: 978  Q---VGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPA 1034

Query: 391  ---KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYD 447
               +G + F++V+F Y S     +LK L   ++S + V +VG +G GKS+ +  + RL +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093

Query: 448  PDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVK 507
            P EG I ID        ++ LR+ + ++ QEPVLF+ T+ +N+     + T +E+  A++
Sbjct: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEH-TDEELWNALQ 1151

Query: 508  EANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
            E    E I  LP K DT + E G+  S GQ+Q + +ARA++R  +IL++DEAT+ +D  +
Sbjct: 1152 EVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRT 1211

Query: 568  EAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGS-HSELMKKEGVYFK 626
            +  +Q  + +     T + IAHRL+T+ ++D I   + G + E    +  L  KE +++K
Sbjct: 1212 DELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYK 1271

Query: 627  LV 628
            +V
Sbjct: 1272 MV 1273



 Score =  113 bits (283), Expect = 1e-24
 Identities = 137/575 (23%), Positives = 246/575 (42%), Gaps = 56/575 (9%)

Query: 710  YFVVGTVCAIANGG--LQPAFSVIFSEIIAIFGPGD--DAVKQQKCNIFSLIFLFLGIIS 765
            Y V+G    I      +QP F     +II  F   D  D+V       ++ +  F  +I 
Sbjct: 92   YLVLGIFTLIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL 148

Query: 766  FFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQ 825
                 L  +    AG  L   +  M ++  LR  +S     K +TG +   L+ D  +  
Sbjct: 149  AILHHLYFYHVQCAGMRLRVAMCHMIYRKALR--LSNMAMGKTTTGQIVNLLSNDVNKFD 206

Query: 826  GATGTRLALIAQNI------ANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLA 879
              T     L A  +      A L   I IS + G  + ++LL   P+ +  G    KL +
Sbjct: 207  QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL---PLQSCFG----KLFS 259

Query: 880  GNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV----EKLYGPYRNSVQKAH 935
                +     +A  +   E I  IR +     E+ F ++      +++    R+S  +  
Sbjct: 260  SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319

Query: 936  IYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI-VFGAVALGHASSFA 994
                 FS S+  ++ ++      G+ +  +          VF A+ ++GAV L   + F 
Sbjct: 320  NLASFFSASKIIVFVTFTTYVLLGSVITASR---------VFVAVTLYGAVRLT-VTLFF 369

Query: 995  PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLK-PDKFEGNITFNEVVFNYPTRANVPVLQ 1053
            P   +    A       +   L+D  S+   + P   +  +   +    +   +  P LQ
Sbjct: 370  PSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ 429

Query: 1054 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLG 1113
            GLS  V+ G+ LA+VG  G GKS+++  +     P  G V + G+             + 
Sbjct: 430  GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IA 476

Query: 1114 IVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1173
             VSQ+P +F  ++  NI +G        ++++   KA  +   ++ L     T +GD+GT
Sbjct: 477  YVSQQPWVFSGTLRSNILFGKKYEKERYEKVI---KACALKKDLQLLEDGDLTVIGDRGT 533

Query: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKVVQEALDKAREGRTCIVIAHR 1232
             LSGGQK R+ +ARA+ +   I LLD+  SA+D E S  + +  + +    +  I++ H+
Sbjct: 534  TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593

Query: 1233 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1267
            L  ++ A  I++ ++G++ + GT+ + L + GI F
Sbjct: 594  LQYLKAASQILILKDGKMVQKGTYTEFL-KSGIDF 627


>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
            sapiens]
          Length = 753

 Score =  207 bits (528), Expect = 4e-53
 Identities = 156/513 (30%), Positives = 253/513 (49%), Gaps = 31/513 (6%)

Query: 776  FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALI 835
            FGK  +   RR+    F  +   D+ +    +  TGALS  +       +G +    AL+
Sbjct: 215  FGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQ--TGALSKAIDRGT---RGISFVLSALV 269

Query: 836  AQNIANLGTGIIISFIY----GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
               +  +   +++S +     G Q  L+ L  +       +   +          K    
Sbjct: 270  FNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND 329

Query: 892  AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFS 951
            AG  A +++ N  TV     ER     Y  + Y  +  + + A +   +   + A + F 
Sbjct: 330  AGNAAIDSLLNYETVKYFNNER-----YEAQRYDGFLKTYETASLKSTS---TLAMLNFG 381

Query: 952  YAGCFRFGAYLI--------VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLS 1003
             +  F  G   I        V G +   D+++V   +   ++ L    +   +  +A + 
Sbjct: 382  QSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALID 441

Query: 1004 AAHLFMLFERQPLI-DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKG 1062
               LF L +    I D      L+       + F+ V F Y     V  L G+S EV  G
Sbjct: 442  MNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGISFEVPAG 499

Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
            + +A+VG SG GKST+V+LL RFY+P  G++ L GQ  + ++++ LR  +G+V Q+ +LF
Sbjct: 500  KKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLF 559

Query: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
              +I  N+ YG+ S   S +E+ + AK A +H  I  +PH Y+T+VG++G +LSGG+KQR
Sbjct: 560  HNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQR 617

Query: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
            +AIARA+++ P ++L DEATS+LD+ +E+ +  A+    + RT I IAHRLST+ +AD I
Sbjct: 618  VAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEI 677

Query: 1243 VVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1274
            +V   G+V E GTH  LLA    IY  M   Q+
Sbjct: 678  IVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710



 Score =  200 bits (509), Expect = 6e-51
 Identities = 173/651 (26%), Positives = 301/651 (46%), Gaps = 55/651 (8%)

Query: 10  TAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYS----DWQDKLFMSLGTIMAI 65
           T W   +  G   L    K+  K   T K+I  +  + +     D + ++ +SLG +   
Sbjct: 95  TCWHGHAGGG---LHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFL--- 148

Query: 66  AHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGA 125
               G   M IV   M    VD+    S  +   L+L +    +    T     Y    A
Sbjct: 149 ---GGAKAMNIVVPFMFKYAVDSLNQMSGNM---LNLSDAPNTVATMATAVLIGYGVSRA 202

Query: 126 GVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKIS 185
           G      ++ + +   A   IR+I +  F  +   ++G+     T  L+  +      IS
Sbjct: 203 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS 262

Query: 186 EGIGDKVGMFFQAVATFFAGFIVGFIRGWK-------LTLVIMAISPILGLSAAVWAKIL 238
             +     + F  +   F   +V  +  +K       +TL  +       ++   W    
Sbjct: 263 FVLS---ALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWR--- 316

Query: 239 SAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
           + F  +   A   AG  A ++L    TV  F  +  E +RY   L+  +   +K   +  
Sbjct: 317 TRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTST-- 374

Query: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
               +A L    S   +    + +V++ +  +   +TV   +++       + P      
Sbjct: 375 ----LAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPL----- 425

Query: 359 NARGAAY-----------VIFDIIDNNPKI-DSFSERGHKPDSIKGNLEFNDVHFSYPSR 406
           N  G  Y            +F ++  + +I D       +       + F++VHF Y   
Sbjct: 426 NFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE- 484

Query: 407 ANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVN 466
              K+L G++ +V +G+ VA+VG SG GKST V+L+ R Y+P +G+I + GQ+I++ ++ 
Sbjct: 485 -GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543

Query: 467 YLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
            LR  +GVV Q+ VLF  TI  N+ YG  + + +E+    K A  ++ I+++P  +DT V
Sbjct: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603

Query: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
           GERG +LSGG+KQR+AIARA++++P ++L DEATS+LD+ +E  +  A+    + RT+I 
Sbjct: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIF 663

Query: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLVNMQTSGSQ 636
           IAHRLSTV +AD I   + G + E+G+H  L+     +Y ++ + Q+S  Q
Sbjct: 664 IAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ 714


>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
            sapiens]
          Length = 1581

 Score =  207 bits (527), Expect = 5e-53
 Identities = 213/928 (22%), Positives = 396/928 (42%), Gaps = 114/928 (12%)

Query: 409  VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL----IQRLY---------------DPD 449
            +  L  + +++  GQ   +VG  GCGKS+ +      +Q++                DP 
Sbjct: 693  IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752

Query: 450  EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
                     DIR       R  +   SQ+P L + T+ ENI +          K  ++  
Sbjct: 753  PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805

Query: 510  NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
            +    I  LP    T +GERG  LSGGQ+QRI++ARAL ++  ++ LD+  SALD     
Sbjct: 806  SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865

Query: 570  EVQAA--LDKAREG-RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
             +  A  L+  R+  RT +++ H+L  + +AD I   +DG I  +G+  +  + E   F+
Sbjct: 866  HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925

Query: 627  ----LVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD 682
                L+N Q      Q  E E   E+ AT   P G    +         +  +  + +  
Sbjct: 926  HWKTLMNRQD-----QELEKETVTERKATE-PPQGLSRAMSSRDGLLQDEEEEEEEAAES 979

Query: 683  VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCA--IANGGLQPAFSVIFSEII---- 736
             E D L + +            + E P+      CA  +++ G+     ++FS+++    
Sbjct: 980  EEDDNLSSMLH----------QRAEIPW----RACAKYLSSAGILLLSLLVFSQLLKHMV 1025

Query: 737  ----------------AIFGPGDDAVKQQKCN----IFSLIFLFLGIISFFTFFLQGFTF 776
                             +     +    Q+C     +++++F  L  +      +   T 
Sbjct: 1026 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTV 1085

Query: 777  GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALI 835
               G  + +RL       ++   M +F+      G++  R ++D   + Q    T   L 
Sbjct: 1086 EWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLS 1143

Query: 836  AQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI 895
               +  +    +IS++      + L+A++P+  V   ++       A RD ++L+   ++
Sbjct: 1144 RSTLLCVSALAVISYV----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQL 1197

Query: 896  A-----TEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYF 950
                   E +E + T+ +   E +F+   +E     Y +S   A ++ +T +     +  
Sbjct: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLE-----YTDSNNIASLF-LTAANRWLEVRM 1251

Query: 951  SYAG-CFRFGAYL--IVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1007
             Y G C    A +  I N   R     LV   + +  +   + +    + A  +L    +
Sbjct: 1252 EYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAV 1311

Query: 1008 FMLFERQPLIDSYSEEGLKPDKF-------EGNITFNEVVFNYPTRANVPVLQGLSLEVK 1060
              +       ++ S EGL            +G I    +   Y +    PVL+ ++  + 
Sbjct: 1312 KRIHGLLKT-EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALIA 1369

Query: 1061 KGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPI 1120
             GQ + + G +G GKS+      R  D   G +++DG +  KL +  LR++L I+ Q+P+
Sbjct: 1370 PGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPV 1429

Query: 1121 LFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK 1180
            LF  +I  N+   D  R  S   +  A + A +   ++ LP   +  + + G   S GQ+
Sbjct: 1430 LFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQR 1486

Query: 1181 QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNAD 1240
            Q   +ARA +R+  I ++DEAT+++D  +E ++Q+ +  A   RT + IAHR+ TI +AD
Sbjct: 1487 QLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSAD 1546

Query: 1241 LIVVFQNGRVKEHGTHQQLLAQKGIYFS 1268
            L++V + G + E    ++LL++K   F+
Sbjct: 1547 LVIVLKRGAILEFDKPEKLLSRKDSVFA 1574



 Score =  120 bits (302), Expect = 6e-27
 Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 3/239 (1%)

Query: 391  KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
            +G ++  ++   Y S     +LK +N  +  GQ + + G +G GKS+      R+ D  E
Sbjct: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399

Query: 451  GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
            G I IDG DI    ++ LR  + ++ Q+PVLFS TI  N+   R   +   + +A++ A 
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER-KCSDSTLWEALEIAQ 1458

Query: 511  AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
                +  LP   D ++ E G   S GQ+Q   +ARA VR   I ++DEAT+++D  +E  
Sbjct: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518

Query: 571  VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
            +Q  +  A   RT + IAHR+ T+ +AD++   + G I+E     +L+ +K+ V+   V
Sbjct: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577



 Score =  107 bits (266), Expect = 1e-22
 Identities = 64/228 (28%), Positives = 119/228 (52%), Gaps = 21/228 (9%)

Query: 1045 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG------- 1097
            T   +P L  +++ + +GQ   +VG  GCGKS+++         ++G V           
Sbjct: 689  TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748

Query: 1098 -------QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
                   + A  L+++  R  +   SQ+P L + ++ ENI +       ++       +A
Sbjct: 749  EDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIF---ESPFNKQRYKMVIEA 804

Query: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
             ++ P I+ LPH  +T++G++G  LSGGQ+QRI++ARAL +   ++ LD+  SALD    
Sbjct: 805  CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864

Query: 1211 KVVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1255
              + +A  L+  R+  RT +++ H+L  + +AD I+  ++G ++  GT
Sbjct: 865  DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912


>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
            [Homo sapiens]
          Length = 1472

 Score =  182 bits (462), Expect = 2e-45
 Identities = 182/783 (23%), Positives = 336/783 (42%), Gaps = 48/783 (6%)

Query: 521  KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR- 579
            K +  V  +G  LSGGQKQR+++ARA+  N  I L D+  SA+D      +   +   + 
Sbjct: 697  KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756

Query: 580  --EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
              + +T I++ H +S +   DVI     G I E GS+ EL+ ++G + + +    S  Q 
Sbjct: 757  MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816

Query: 638  Q-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE--------TDGL 688
            Q +EE  +       + A       L   S  K L+       S   +         +  
Sbjct: 817  QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ 876

Query: 689  EANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCAIANGGLQPA--FSVIFSEII 736
            +A        K+++ +K +         W Y   +G   +  +  L      S + S   
Sbjct: 877  KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 936

Query: 737  AIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKA 794
                  D  V   Q+   +   ++  LGI      F         G + +R L      +
Sbjct: 937  LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 996

Query: 795  MLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW 854
            +LR  MS+F+  +  +G L  R + +   V       + +   ++ N+    I+  +   
Sbjct: 997  ILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL--- 1051

Query: 855  QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERK 914
              T +   ++P + +      +    ++ R  K LE+  +    +  N  T++ ++  R 
Sbjct: 1052 -ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSRSPVYSHFN-ETLLGVSVIRA 1108

Query: 915  FESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFSYAGCFRFGAYL--IVNGHMR 969
            FE    E+        V   QKA+   I  +   A        C    A L  +++ H  
Sbjct: 1109 FEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSL 1166

Query: 970  FRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD 1028
               ++ L  S  +     L      + +     ++   L    E +       +E   P 
Sbjct: 1167 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1226

Query: 1029 KFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1086
             +   G + F      Y    +  VL+ +++ +  G+ + +VG +G GKS++   L R  
Sbjct: 1227 SWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1285

Query: 1087 DPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVS 1146
            +   G +++DG    K+ +  LR ++ I+ Q+P+LF  S+  N+   D     S +E+ +
Sbjct: 1286 ESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWT 1342

Query: 1147 AAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALD 1206
            + + A++  F+  LP K +    + G  LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D
Sbjct: 1343 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1402

Query: 1207 TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIY 1266
             E++ ++Q  +    E  T + IAHRL+TI +   ++V   G ++E+G    LL Q+G++
Sbjct: 1403 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1462

Query: 1267 FSM 1269
            +SM
Sbjct: 1463 YSM 1465



 Score =  137 bits (345), Expect = 7e-32
 Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)

Query: 97   NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
            N+ LSL     I+    E    R + Y + G+  G+ V  Y + VS   + A R +    
Sbjct: 934  NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 991

Query: 151  QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
                H+ILR  + +F+   +  L  R + ++  +   I + + MF  ++       IV  
Sbjct: 992  -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050

Query: 211  IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
            +     T +   I P LGL      +   A S   K L + +++   +   E L  +  +
Sbjct: 1051 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1106

Query: 267  IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
             AF    +E ER+  H  + K    +KA   +I  +  +A  L      +  +     VI
Sbjct: 1107 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161

Query: 325  SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
            S+         ++V +S+ +  +         +   N   A   + +  +   +     +
Sbjct: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1220

Query: 383  RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
                P S    G +EF +    Y    +  +L+ +N+ +  G+ V +VG +G GKS+   
Sbjct: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279

Query: 441  LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
             + R+ +  EG I IDG +I    ++ LR  I ++ Q+PVLFS ++  N+       + +
Sbjct: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1338

Query: 501  EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
            E+  +++ A+  +F+  LP K D    E G  LS GQ+Q + +ARAL+R  KIL+LDEAT
Sbjct: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398

Query: 561  SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
            +A+D E++  +Q+ +    E  T + IAHRL+T+ +   +   + G I E G+ S+L+++
Sbjct: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458

Query: 621  EGVYFKL 627
             G+++ +
Sbjct: 1459 RGLFYSM 1465



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 41/118 (34%), Positives = 67/118 (56%), Gaps = 3/118 (2%)

Query: 1163 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR- 1221
            K E  V  KG  LSGGQKQR+++ARA+     I L D+  SA+D    K + E +   + 
Sbjct: 697  KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756

Query: 1222 --EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
              + +T I++ H +S +   D+I+V   G++ E G++Q+LLA+ G +   +   A T+
Sbjct: 757  MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 814


>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
            [Homo sapiens]
          Length = 1475

 Score =  166 bits (421), Expect = 1e-40
 Identities = 198/923 (21%), Positives = 369/923 (39%), Gaps = 113/923 (12%)

Query: 378  DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
            DS   R  K      ++   +  F++ +R++   L G+   +  G  VA+VG  GCGKS+
Sbjct: 628  DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686

Query: 438  TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
             +  +    D  EG + I G              +  V Q+  + + ++ ENI +     
Sbjct: 687  LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILF----- 728

Query: 498  TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
                                            G QL     + +  A AL+ + +IL   
Sbjct: 729  --------------------------------GCQLEEPYYRSVIQACALLPDLEILPSG 756

Query: 558  EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL 617
            + T   +                 +T I++ H +S +   DVI     G I E GS+ EL
Sbjct: 757  DRTEIGE-----------------KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 799

Query: 618  MKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQM 676
            + ++G + + +    S  Q Q +EE  +       + A       L   S  K L+    
Sbjct: 800  LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLS 859

Query: 677  CQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCA 718
               S   +         +  +A        K+++ +K +         W Y   +G   +
Sbjct: 860  SSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFIS 919

Query: 719  IANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGF 774
              +  L      S + S         D  V   Q+   +   ++  LGI      F    
Sbjct: 920  FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSM 979

Query: 775  TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLAL 834
                 G + +R L      ++LR  MS+F+  +  +G L  R + +   V       + +
Sbjct: 980  AVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKM 1037

Query: 835  IAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGK 894
               ++ N+    I+  +     T +   ++P + +      +    ++ R  K LE+  +
Sbjct: 1038 FMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSR 1092

Query: 895  IATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFS 951
                +  N  T++ ++  R FE    E+        V   QKA+   I  +   A     
Sbjct: 1093 SPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1149

Query: 952  YAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
               C    A L  +++ H     ++ L  S  +     L      + +     ++   L 
Sbjct: 1150 VGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLK 1209

Query: 1009 MLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLA 1066
               E +       +E   P  +   G + F      Y    +  VL+ +++ +  G+ + 
Sbjct: 1210 EYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVG 1268

Query: 1067 LVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSI 1126
            +VG +G GKS++   L R  +   G +++DG    K+ +  LR ++ I+ Q+P+LF  S+
Sbjct: 1269 IVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSL 1328

Query: 1127 AENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIA 1186
              N+   D     S +E+ ++ + A++  F+  LP K +    + G  LS GQ+Q + +A
Sbjct: 1329 RMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLA 1385

Query: 1187 RALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1246
            RAL+R+ +IL+LDEAT+A+D E++ ++Q  +    E  T + IAHRL+TI +   ++V  
Sbjct: 1386 RALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLD 1445

Query: 1247 NGRVKEHGTHQQLLAQKGIYFSM 1269
             G ++E+G    LL Q+G+++SM
Sbjct: 1446 KGEIQEYGAPSDLLQQRGLFYSM 1468



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 61/267 (22%), Positives = 104/267 (38%), Gaps = 80/267 (29%)

Query: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
            S E L+PD  E           +IT     F +  R++ P L G++  + +G  +A+VG 
Sbjct: 621  SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679

Query: 1071 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1130
             GCGKS+++  L    D + G V + G  A              V Q+  + + S+ ENI
Sbjct: 680  VGCGKSSLLSALLAEMDKVEGHVAIKGSVA-------------YVPQQAWIQNDSLRENI 726

Query: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
             +G     + +    S  +A  + P +E LP    T +         G+K RI +  ++ 
Sbjct: 727  LFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEI---------GEKTRILVTHSMS 774

Query: 1191 RQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1250
              PQ+                                            D+I+V   G++
Sbjct: 775  YLPQV--------------------------------------------DVIIVMSGGKI 790

Query: 1251 KEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
             E G++Q+LLA+ G +   +   A T+
Sbjct: 791  SEMGSYQELLARDGAFAEFLRTYASTE 817


>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
            [Homo sapiens]
          Length = 1416

 Score =  153 bits (386), Expect = 1e-36
 Identities = 161/719 (22%), Positives = 303/719 (42%), Gaps = 45/719 (6%)

Query: 582  RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQ-SE 640
            +T I++ H +S +   DVI     G I E GS+ EL+ ++G + + +    S  Q Q +E
Sbjct: 705  KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764

Query: 641  EFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE--------TDGLEANV 692
            E  +       + A       L   S  K L+       S   +         +  +A  
Sbjct: 765  ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824

Query: 693  PPVSFLKVLKLNKTE---------WPYF-VVGTVCAIANGGLQPA--FSVIFSEIIAIFG 740
                  K+++ +K +         W Y   +G   +  +  L      S + S       
Sbjct: 825  KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884

Query: 741  PGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQ 798
              D  V   Q+   +   ++  LGI      F         G + +R L      ++LR 
Sbjct: 885  TDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRS 944

Query: 799  DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTL 858
             MS+F+  +  +G L  R + +   V       + +   ++ N+    I+  +     T 
Sbjct: 945  PMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATP 998

Query: 859  LLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESM 918
            +   ++P + +      +    ++ R  K LE+  +    +  N  T++ ++  R FE  
Sbjct: 999  IAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSRSPVYSHFN-ETLLGVSVIRAFEEQ 1056

Query: 919  YVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFSYAGCFRFGAYL--IVNGHMRFRDV 973
              E+        V   QKA+   I  +   A        C    A L  +++ H     +
Sbjct: 1057 --ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGL 1114

Query: 974  I-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE- 1031
            + L  S  +     L      + +     ++   L    E +       +E   P  +  
Sbjct: 1115 VGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQ 1174

Query: 1032 -GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
             G + F      Y    +  VL+ +++ +  G+ + +VG +G GKS++   L R  +   
Sbjct: 1175 VGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1233

Query: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
            G +++DG    K+ +  LR ++ I+ Q+P+LF  S+  N+   D     S +E+ ++ + 
Sbjct: 1234 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLEL 1290

Query: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
            A++  F+  LP K +    + G  LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1291 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1350

Query: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
             ++Q  +    E  T + IAHRL+TI +   ++V   G ++E+G    LL Q+G+++SM
Sbjct: 1351 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1409



 Score =  137 bits (345), Expect = 7e-32
 Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)

Query: 97   NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
            N+ LSL     I+    E    R + Y + G+  G+ V  Y + VS   + A R +    
Sbjct: 878  NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 935

Query: 151  QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
                H+ILR  + +F+   +  L  R + ++  +   I + + MF  ++       IV  
Sbjct: 936  -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 994

Query: 211  IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
            +     T +   I P LGL      +   A S   K L + +++   +   E L  +  +
Sbjct: 995  LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050

Query: 267  IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
             AF    +E ER+  H  + K    +KA   +I  +  +A  L      +  +     VI
Sbjct: 1051 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1105

Query: 325  SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
            S+         ++V +S+ +  +         +   N   A   + +  +   +     +
Sbjct: 1106 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1164

Query: 383  RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
                P S    G +EF +    Y    +  +L+ +N+ +  G+ V +VG +G GKS+   
Sbjct: 1165 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223

Query: 441  LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
             + R+ +  EG I IDG +I    ++ LR  I ++ Q+PVLFS ++  N+       + +
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1282

Query: 501  EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
            E+  +++ A+  +F+  LP K D    E G  LS GQ+Q + +ARAL+R  KIL+LDEAT
Sbjct: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342

Query: 561  SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
            +A+D E++  +Q+ +    E  T + IAHRL+T+ +   +   + G I E G+ S+L+++
Sbjct: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402

Query: 621  EGVYFKL 627
             G+++ +
Sbjct: 1403 RGLFYSM 1409



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 5/75 (6%)

Query: 1203 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1262
            SAL  E +KV      K R     I++ H +S +   D+I+V   G++ E G++Q+LLA+
Sbjct: 689  SALLAEMDKVEGHVAIKTR-----ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743

Query: 1263 KGIYFSMVSVQAGTQ 1277
             G +   +   A T+
Sbjct: 744  DGAFAEFLRTYASTE 758



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 11/85 (12%)

Query: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
            S E L+PD  E           +IT     F +  R++ P L G++  + +G  +A+VG 
Sbjct: 621  SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679

Query: 1071 SGCGKSTVVQLLERFYDPLAGTVLL 1095
             GCGKS+++  L    D + G V +
Sbjct: 680  VGCGKSSLLSALLAEMDKVEGHVAI 704



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 1/94 (1%)

Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
           DS   R  K      ++   +  F++ +R++   L G+   +  G  VA+VG  GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686

Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
            +  +    D  EG + I  + +   +++YL ++
Sbjct: 687 LLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720


>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
            [Homo sapiens]
          Length = 1545

 Score =  149 bits (377), Expect = 1e-35
 Identities = 136/527 (25%), Positives = 249/527 (47%), Gaps = 27/527 (5%)

Query: 110  EEEMTRYAYYYSGLGAGVLV-AAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDIN 168
            + +M    Y   GL  G+ V  A+   +F  + A   + K   +  + ILR  + +FD  
Sbjct: 1019 QRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHK---QLLNNILRAPMRFFDTT 1075

Query: 169  DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILG 228
             T  +  R   DIS +     D +    ++  T F G I   +     T V   I   LG
Sbjct: 1076 PTGRIVNRFAGDISTVD----DTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLG 1131

Query: 229  LSAAVWAKILSAFSDKEL-----AAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
            +   V  ++    + ++L        +   +   E +  +  + AF  Q + L+  +  +
Sbjct: 1132 I-IYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRI 1190

Query: 284  ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
            +  ++  +   I++N  + I   L+       F+    +VI ++   G+  TV F +L  
Sbjct: 1191 DTNQKC-VFSWITSNRWLAIRLELV--GNLTVFFSALMMVIYRDTLSGD--TVGF-VLSN 1244

Query: 344  AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDS----FSERGHKPD-SIKGNLEFND 398
            A ++ Q    +    +      V  + I    K+++     +++   PD   KG ++FN+
Sbjct: 1245 ALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNN 1304

Query: 399  VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
                Y    ++ +L+G+   + S + + +VG +G GKS+    + R+ +   G I IDG 
Sbjct: 1305 YQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGV 1363

Query: 459  DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKL 518
            DI +  ++ LRE + ++ Q+P+LFS ++  N+     N + +EI KA++ A+   F+  L
Sbjct: 1364 DIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASL 1422

Query: 519  PQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 578
                   V E G  LS GQ+Q + + RAL+R  KIL+LDEAT+A+D E++  +Q  +   
Sbjct: 1423 QLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNE 1482

Query: 579  REGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
                T I IAHRL T+ ++D +   ++G I+E GS  EL++  G ++
Sbjct: 1483 FAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529



 Score =  142 bits (358), Expect = 2e-33
 Identities = 82/249 (32%), Positives = 144/249 (57%), Gaps = 5/249 (2%)

Query: 1031 EGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
            +G I FN     Y    ++ VL+G++ ++   + + +VG +G GKS++   L R  +   
Sbjct: 1297 KGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAG 1355

Query: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
            G +++DG +   + +  LR +L I+ Q+PILF  S+  N+   +N    S +EI  A + 
Sbjct: 1356 GQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNN---YSDEEIWKALEL 1412

Query: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
            A++  F+ +L       V + G  LS GQ+Q + + RAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1413 AHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETD 1472

Query: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
             ++Q  +       T I IAHRL TI ++D ++V  NG++ E G+ ++LL   G ++ M 
Sbjct: 1473 NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMA 1532

Query: 1271 SVQAGTQNL 1279
              +AG +N+
Sbjct: 1533 K-EAGIENV 1540



 Score =  105 bits (262), Expect = 3e-22
 Identities = 96/410 (23%), Positives = 176/410 (42%), Gaps = 29/410 (7%)

Query: 859  LLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESM 918
            +++ V+PI A+       +   N K   K L    KI  E +  I+ +     E  F   
Sbjct: 469  VMVLVIPINAILSTKSKTIQVKNMKNKDKRL----KIMNEILSGIKILKYFAWEPSFRDQ 524

Query: 919  YVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFS 978
                     +N +  + +  +   + Q            F  Y++V+ +    D    F+
Sbjct: 525  VQNLRKKELKNLLAFSQLQCVVIFVFQLTPVL--VSVVTFSVYVLVDSN-NILDAQKAFT 581

Query: 979  AIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITFN 1037
            +I    + L    S  P    + L A+      E+    D      ++ D  F+  + F+
Sbjct: 582  SITLFNI-LRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFS 640

Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1097
            E  F +   +   V + ++L++  GQ +A++G  G GKS+++  +    + + G + + G
Sbjct: 641  EASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG 699

Query: 1098 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1157
              A      W++             + +I +NI +G         +++ A     + P +
Sbjct: 700  TTAYVPQQSWIQ-------------NGTIKDNILFGTEFNEKRYQQVLEACA---LLPDL 743

Query: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1217
            E LP      +G+KG  LSGGQKQRI++ARA  +   I LLD+  SA+D    K +   +
Sbjct: 744  EMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKV 803

Query: 1218 ---DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1264
               +   +G+T +++ H +  +   D IVV  NG + E G++  LLA+KG
Sbjct: 804  LGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKG 853



 Score =  102 bits (253), Expect = 3e-21
 Identities = 115/482 (23%), Positives = 204/482 (42%), Gaps = 78/482 (16%)

Query: 394  LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI 453
            ++F++  F++   +   + + +NL + +GQ VA++G  G GKS+ +  +    +   G I
Sbjct: 637  MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695

Query: 454  NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE 513
             I G                 V Q+  + + TI +NI +G         ++ ++      
Sbjct: 696  TIKGTT-------------AYVPQQSWIQNGTIKDNILFGT-EFNEKRYQQVLEACALLP 741

Query: 514  FIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQA 573
             +  LP      +GE+G  LSGGQKQRI++ARA  +N  I LLD+  SA+D      +  
Sbjct: 742  DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801

Query: 574  AL---DKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
             +   +   +G+T +++ H +  +   D I    +G IVE+GS+S L+ K+G + K  N+
Sbjct: 802  KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK--NL 859

Query: 631  QT--------------SGSQIQSEEF-------ELNDEKAATRMAPNGWKSRLFRHSTQK 669
            +T               GS+ + +++       E+ ++ A+  M       R    S++ 
Sbjct: 860  KTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRS 919

Query: 670  NLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVC------AIANGG 723
            N ++ +  + SL  +T  + +       +K  KL K E  +   G V        +   G
Sbjct: 920  NGRHLKSLRNSL--KTRNVNSLKEDEELVKGQKLIKKE--FIETGKVKFSIYLEYLQAIG 975

Query: 724  LQPAFSVIFSEII-------------------AIFGPGDDAVKQQ--KCNIFSLIFLFLG 762
            L   F +I + ++                    IF   D    Q+  +  ++  + L  G
Sbjct: 976  LFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQG 1035

Query: 763  IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
            I  F   F   F F  A  IL ++L       +LR  M +FD     TG +  R A D +
Sbjct: 1036 IFVFIAHFWSAFGFVHASNILHKQL----LNNILRAPMRFFD--TTPTGRIVNRFAGDIS 1089

Query: 823  QV 824
             V
Sbjct: 1090 TV 1091


>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
          Length = 1359

 Score =  149 bits (375), Expect = 2e-35
 Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 2/238 (0%)

Query: 391  KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
            +G + F D    Y     + +L  LNL +QSGQTV +VG +G GKS+    + RL +P  
Sbjct: 1117 RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175

Query: 451  GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
            GTI ID  DI   ++  LR  + V+ Q+PVLF  T+  N+     + T + + + ++   
Sbjct: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTF 1234

Query: 511  AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
              + IMKLP+K    V E G   S G++Q + +ARAL+RN KI+LLDEAT+++D++++  
Sbjct: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294

Query: 571  VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
            VQ  +  A +G T + IAHRL+TV N D +   E+G ++E      L +K    F ++
Sbjct: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352



 Score =  141 bits (356), Expect = 3e-33
 Identities = 80/240 (33%), Positives = 140/240 (58%), Gaps = 6/240 (2%)

Query: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
            G ITF +    Y  R N P VL  L+L ++ GQT+ +VG +G GKS++   L R  +P +
Sbjct: 1118 GEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175

Query: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
            GT+ +D  +   L+++ LR +L ++ Q+P+LF  ++  N+   D     + + +    + 
Sbjct: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEMLWQVLER 1232

Query: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
              +   I  LP K +  V + G   S G++Q + +ARAL+R  +I+LLDEAT+++D++++
Sbjct: 1233 TFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTD 1292

Query: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
             +VQ  +  A +G T + IAHRL+T+ N D ++V +NG+V E    + L  +    F+M+
Sbjct: 1293 TLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352



 Score =  118 bits (295), Expect = 4e-26
 Identities = 67/228 (29%), Positives = 120/228 (52%), Gaps = 17/228 (7%)

Query: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1110
            VL  +S  V+KG+ L + G+ G GKS+++  L        G V ++G             
Sbjct: 495  VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542

Query: 1111 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1170
             L  VSQ+  +F  ++ ENI +G+              +   +   +  LP+   T +G+
Sbjct: 543  -LAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598

Query: 1171 KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIVI 1229
            +G  LSGGQ+QRI++ARA+    Q+ LLD+  SA+D    K V +E + K   G+T +++
Sbjct: 599  RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658

Query: 1230 AHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
             H+L  +++ D +++ ++G + E GTH++L+ ++G Y  ++    G Q
Sbjct: 659  THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706



 Score =  113 bits (283), Expect = 1e-24
 Identities = 117/512 (22%), Positives = 209/512 (40%), Gaps = 63/512 (12%)

Query: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
           +L  ++  V+ G+ + + G+ G GKS+ +  +       +G + ++G             
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542

Query: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
            +  VSQ+  +F   + ENI +G         +  V+     + +  LP    T +GERG
Sbjct: 543 -LAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600

Query: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAH 589
             LSGGQ+QRI++ARA+  + ++ LLD+  SA+D      V +  + K   G+T +++ H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660

Query: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELN---- 645
           +L  + + D +   EDG I E+G+H ELM++ G Y KL++    G Q +  E   N    
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH-NLRGLQFKDPEHLYNAAMV 719

Query: 646 ---DEKAATR--------MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
               E  A R        +AP   K       T     ++++ +  L       E  V  
Sbjct: 720 EAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTW 779

Query: 695 VSFLKVLKLNK-------TEWPYFVVGTVCAIANGGL------------QPAFSVIFSEI 735
            ++   +K +        T + + ++    A +N  L             P  +    E+
Sbjct: 780 KTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839

Query: 736 IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAM 795
            A+       V Q       +  L  G+        +GF F K   + +  L    F  +
Sbjct: 840 GAVLADIGQHVYQWVYTASMVFMLVFGV-------TKGFVFTKTTLMASSSLHDTVFDKI 892

Query: 796 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQ 855
           L+  MS+FD     TG L  R + D  ++      RL   A+N       ++   +    
Sbjct: 893 LKSPMSFFD--TTPTGRLMNRFSKDMDELD----VRLPFHAENFLQQFFMVVFILVILAA 946

Query: 856 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKK 887
           +   +L VV  +AV   + +++     +  KK
Sbjct: 947 VFPAVLLVVASLAVGFFILLRIFHRGVQELKK 978


>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
            [Homo sapiens]
          Length = 1382

 Score =  145 bits (365), Expect = 3e-34
 Identities = 92/248 (37%), Positives = 140/248 (56%), Gaps = 5/248 (2%)

Query: 392  GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
            G + F D H  Y       +L G+NL ++  + V +VG +G GKS+    + RL +P  G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197

Query: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENIC-YGRGNVTMDEIKKAVKEAN 510
             I IDG DI +  +  LR  + V+ Q+PVL S TI  N+  + R   T  +I  A++   
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255

Query: 511  AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
              + I K P+K  T V E G   S G++Q + IARA++RN KI+L+DEAT+++D E++  
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315

Query: 571  VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
            +Q  + +A +G T +VIAHR++TV N D I    +G +VE      L KK G  F  + M
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-M 1374

Query: 631  QTSGSQIQ 638
             T+ S ++
Sbjct: 1375 ATATSSLR 1382



 Score =  139 bits (351), Expect = 1e-32
 Identities = 80/244 (32%), Positives = 140/244 (57%), Gaps = 6/244 (2%)

Query: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
            G I F +    Y  R N P VL G++L ++  + + +VG +G GKS++   L R  +P+A
Sbjct: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196

Query: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
            G +L+DG +   + ++ LR++L ++ Q+P+L   +I  N+   D     +  +I  A + 
Sbjct: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQQIWDALER 1253

Query: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
              +   I   P K  T V + G   S G++Q + IARA++R  +I+L+DEAT+++D E++
Sbjct: 1254 TFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1313

Query: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
             ++Q  + +A +G T +VIAHR++T+ N D I+V  NG+V E    + L  + G  F+ +
Sbjct: 1314 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1373

Query: 1271 SVQA 1274
               A
Sbjct: 1374 MATA 1377



 Score =  114 bits (285), Expect = 6e-25
 Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)

Query: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109
            P L  ++L V KG  L + G++G GKS+++  +      L G+V + G            
Sbjct: 525  PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573

Query: 1110 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1169
              L  V Q+  +   +I ENI  G       +   +      +++  +E LP    T +G
Sbjct: 574  --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628

Query: 1170 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1228
            ++G  LSGGQKQRI++ARA+    QI LLD+  SA+D    K + +E + K   G+T ++
Sbjct: 629  ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688

Query: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
            + H+L  ++    I++ +NG++ E+GTH +L+ +KG Y  ++
Sbjct: 689  VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730



 Score =  102 bits (253), Expect = 3e-21
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)

Query: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
           L  +NL V  G  + + G++G GKS+ +  I       EG++ + G              
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573

Query: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
           +  V Q+  + S  I ENI  G G        + +   +    +  LP    T +GERG 
Sbjct: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632

Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
            LSGGQKQRI++ARA+  + +I LLD+  SA+D      + +  + K   G+T +++ H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692

Query: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
           L  +     I   E+G I E G+HSELM+K+G Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730


>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
            [Homo sapiens]
          Length = 1382

 Score =  145 bits (365), Expect = 3e-34
 Identities = 92/248 (37%), Positives = 140/248 (56%), Gaps = 5/248 (2%)

Query: 392  GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
            G + F D H  Y       +L G+NL ++  + V +VG +G GKS+    + RL +P  G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197

Query: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENIC-YGRGNVTMDEIKKAVKEAN 510
             I IDG DI +  +  LR  + V+ Q+PVL S TI  N+  + R   T  +I  A++   
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255

Query: 511  AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
              + I K P+K  T V E G   S G++Q + IARA++RN KI+L+DEAT+++D E++  
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315

Query: 571  VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
            +Q  + +A +G T +VIAHR++TV N D I    +G +VE      L KK G  F  + M
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-M 1374

Query: 631  QTSGSQIQ 638
             T+ S ++
Sbjct: 1375 ATATSSLR 1382



 Score =  139 bits (351), Expect = 1e-32
 Identities = 80/244 (32%), Positives = 140/244 (57%), Gaps = 6/244 (2%)

Query: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
            G I F +    Y  R N P VL G++L ++  + + +VG +G GKS++   L R  +P+A
Sbjct: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196

Query: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
            G +L+DG +   + ++ LR++L ++ Q+P+L   +I  N+   D     +  +I  A + 
Sbjct: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQQIWDALER 1253

Query: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
              +   I   P K  T V + G   S G++Q + IARA++R  +I+L+DEAT+++D E++
Sbjct: 1254 TFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1313

Query: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
             ++Q  + +A +G T +VIAHR++T+ N D I+V  NG+V E    + L  + G  F+ +
Sbjct: 1314 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1373

Query: 1271 SVQA 1274
               A
Sbjct: 1374 MATA 1377



 Score =  114 bits (285), Expect = 6e-25
 Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)

Query: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109
            P L  ++L V KG  L + G++G GKS+++  +      L G+V + G            
Sbjct: 525  PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573

Query: 1110 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1169
              L  V Q+  +   +I ENI  G       +   +      +++  +E LP    T +G
Sbjct: 574  --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628

Query: 1170 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1228
            ++G  LSGGQKQRI++ARA+    QI LLD+  SA+D    K + +E + K   G+T ++
Sbjct: 629  ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688

Query: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
            + H+L  ++    I++ +NG++ E+GTH +L+ +KG Y  ++
Sbjct: 689  VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730



 Score =  102 bits (253), Expect = 3e-21
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)

Query: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
           L  +NL V  G  + + G++G GKS+ +  I       EG++ + G              
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573

Query: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
           +  V Q+  + S  I ENI  G G        + +   +    +  LP    T +GERG 
Sbjct: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632

Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
            LSGGQKQRI++ARA+  + +I LLD+  SA+D      + +  + K   G+T +++ H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692

Query: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
           L  +     I   E+G I E G+HSELM+K+G Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,310,574
Number of Sequences: 37866
Number of extensions: 1603869
Number of successful extensions: 4694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 4050
Number of HSP's gapped (non-prelim): 332
length of query: 1279
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1165
effective length of database: 13,930,794
effective search space: 16229375010
effective search space used: 16229375010
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.