Guide to the Human Genome
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Search of human proteins with 130502140

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|130502140 NEZHA isoform 2 [Homo sapiens]
         (1249 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|130502140 NEZHA isoform 2 [Homo sapiens]                          2498   0.0  
gi|122937255 NEZHA isoform 1 [Homo sapiens]                          2484   0.0  
gi|44955929 calmodulin regulated spectrin-associated protein 1-l...   669   0.0  
gi|186659512 calmodulin regulated spectrin-associated protein 1 ...   367   e-101
gi|163965366 nascent polypeptide-associated complex alpha subuni...    72   3e-12
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    72   4e-12
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     69   3e-11
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         67   1e-10
gi|150170670 piccolo isoform 2 [Homo sapiens]                          67   1e-10
gi|150378539 piccolo isoform 1 [Homo sapiens]                          67   1e-10
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    65   3e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    63   2e-09
gi|116256464 hypothetical protein LOC343990 [Homo sapiens]             62   3e-09
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    62   3e-09
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    62   3e-09
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       61   8e-09
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   60   1e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   60   1e-08
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   60   1e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    60   1e-08
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              60   1e-08
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    60   1e-08
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    60   1e-08
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    60   1e-08
gi|157785645 SPEG complex locus [Homo sapiens]                         60   2e-08
gi|39930375 enabled homolog isoform b [Homo sapiens]                   59   2e-08
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    59   2e-08
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]       59   4e-08
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       59   4e-08
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     59   4e-08

>gi|130502140 NEZHA isoform 2 [Homo sapiens]
          Length = 1249

 Score = 2498 bits (6475), Expect = 0.0
 Identities = 1249/1249 (100%), Positives = 1249/1249 (100%)

Query: 1    MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPF 60
            MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPF
Sbjct: 1    MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPF 60

Query: 61   YTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPER 120
            YTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPER
Sbjct: 61   YTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPER 120

Query: 121  PVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRL 180
            PVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRL
Sbjct: 121  PVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRL 180

Query: 181  QEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRAPCFPTVTSLQDLASGAALAA 240
            QEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRAPCFPTVTSLQDLASGAALAA
Sbjct: 181  QEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRAPCFPTVTSLQDLASGAALAA 240

Query: 241  TIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLK 300
            TIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLK
Sbjct: 241  TIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLK 300

Query: 301  VNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPL 360
            VNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPL
Sbjct: 301  VNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPL 360

Query: 361  LSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVV 420
            LSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVV
Sbjct: 361  LSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVV 420

Query: 421  MGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAAD 480
            MGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAAD
Sbjct: 421  MGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAAD 480

Query: 481  GSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKP 540
            GSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKP
Sbjct: 481  GSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKP 540

Query: 541  PAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEM 600
            PAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEM
Sbjct: 541  PAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEM 600

Query: 601  SELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGP 660
            SELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGP
Sbjct: 601  SELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGP 660

Query: 661  VPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
            VPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL
Sbjct: 661  VPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720

Query: 721  TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRS 780
            TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRS
Sbjct: 721  TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRS 780

Query: 781  PKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAAR 840
            PKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAAR
Sbjct: 781  PKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAAR 840

Query: 841  PGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMA 900
            PGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMA
Sbjct: 841  PGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMA 900

Query: 901  QKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAP 960
            QKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAP
Sbjct: 901  QKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAP 960

Query: 961  AARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRS 1020
            AARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRS
Sbjct: 961  AARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRS 1020

Query: 1021 GCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMS 1080
            GCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMS
Sbjct: 1021 GCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMS 1080

Query: 1081 PSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNE 1140
            PSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNE
Sbjct: 1081 PSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNE 1140

Query: 1141 PQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEG 1200
            PQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEG
Sbjct: 1141 PQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEG 1200

Query: 1201 IYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTTPKKGGGTPK 1249
            IYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTTPKKGGGTPK
Sbjct: 1201 IYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTTPKKGGGTPK 1249


>gi|122937255 NEZHA isoform 1 [Homo sapiens]
          Length = 1276

 Score = 2484 bits (6437), Expect = 0.0
 Identities = 1249/1276 (97%), Positives = 1249/1276 (97%), Gaps = 27/1276 (2%)

Query: 1    MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPF 60
            MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPF
Sbjct: 1    MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPF 60

Query: 61   YTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPER 120
            YTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPER
Sbjct: 61   YTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPER 120

Query: 121  PVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRL 180
            PVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRL
Sbjct: 121  PVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRL 180

Query: 181  QEKTEQEAAQRASPAAPADGAAPAQPS---------------------------IRYRKD 213
            QEKTEQEAAQRASPAAPADGAAPAQPS                           IRYRKD
Sbjct: 181  QEKTEQEAAQRASPAAPADGAAPAQPSCPTRWYWKLVPHAIAFCLKESGSKPPMIRYRKD 240

Query: 214  RVVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLV 273
            RVVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLV
Sbjct: 241  RVVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLV 300

Query: 274  QDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAA 333
            QDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAA
Sbjct: 301  QDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAA 360

Query: 334  SPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAW 393
            SPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAW
Sbjct: 361  SPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAW 420

Query: 394  NRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEP 453
            NRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEP
Sbjct: 421  NRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEP 480

Query: 454  GDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRP 513
            GDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRP
Sbjct: 481  GDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRP 540

Query: 514  TKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQ 573
            TKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQ
Sbjct: 541  TKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQ 600

Query: 574  LVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLG 633
            LVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLG
Sbjct: 601  LVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLG 660

Query: 634  KSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPH 693
            KSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPH
Sbjct: 661  KSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPH 720

Query: 694  EGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPK 753
            EGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPK
Sbjct: 721  EGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPK 780

Query: 754  AASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKF 813
            AASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKF
Sbjct: 781  AASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKF 840

Query: 814  SPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEE 873
            SPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEE
Sbjct: 841  SPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEE 900

Query: 874  EASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRRE 933
            EASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRRE
Sbjct: 901  EASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRRE 960

Query: 934  EAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDD 993
            EAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDD
Sbjct: 961  EAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDD 1020

Query: 994  LDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLS 1053
            LDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLS
Sbjct: 1021 LDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLS 1080

Query: 1054 TVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLY 1113
            TVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLY
Sbjct: 1081 TVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLY 1140

Query: 1114 KEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALY 1173
            KEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALY
Sbjct: 1141 KEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALY 1200

Query: 1174 TLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLW 1233
            TLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLW
Sbjct: 1201 TLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLW 1260

Query: 1234 QGKKPTTPKKGGGTPK 1249
            QGKKPTTPKKGGGTPK
Sbjct: 1261 QGKKPTTPKKGGGTPK 1276


>gi|44955929 calmodulin regulated spectrin-associated protein 1-like 1
            [Homo sapiens]
          Length = 1478

 Score =  669 bits (1725), Expect = 0.0
 Identities = 519/1517 (34%), Positives = 730/1517 (48%), Gaps = 333/1517 (21%)

Query: 9    PGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQE 68
            P  +R+TF+VP IK  D YDFSRAK A +LAW++  AFG  E+VP EL EPFYTDQY QE
Sbjct: 7    PREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFG-TENVPEELQEPFYTDQYDQE 65

Query: 69   HVKPPVTRLLLSAELYCRAWRQALPQLETPP--NPSALLALLARRGTVPALPERPVREAD 126
            H+KPPV  LLLSAELYCRA    L      P     A++  LA++G      E+ V E D
Sbjct: 66   HIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERD 125

Query: 127  LRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTS--------------LEHKLLFW 172
            L  +PI M AHLA+ID LM A+  E   ++   +A                 +E  +++W
Sbjct: 126  LHKKPIQMSAHLAMIDTLMMAYTVEMV-SIEKVIACAQQYSAFFQATDLPYDIEDAVMYW 184

Query: 173  VDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRAPCFPTVTSL-QD 231
            ++     L++  EQE   +      A G   A    RYRK++ + ++ PC P V +L +D
Sbjct: 185  INKVNEHLKDIMEQEQKLKEHHTVEAPGGQKA----RYRKEQTLLKQLPCIPLVENLLKD 240

Query: 232  LASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLED 291
               G ALAA IH YCP ++RLE++CLK+ MS+ADSLYNLQL+Q+FC   L + C  +LED
Sbjct: 241  GTDGCALAALIHFYCPDVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLED 300

Query: 292  LLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQ-----------VKDLPDG---HAASPRG 337
            +LY    +K N +V +AELF  FEV+KP FVQ           VKD+P     +AA    
Sbjct: 301  MLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV 360

Query: 338  TEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAW---- 393
             ++S    +SG  +      H L S          ++G ++ S SMS+++     W    
Sbjct: 361  LDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEK 420

Query: 394  ------------------------NRQLSRPLS--------------------------- 402
                                    NR ++R +S                           
Sbjct: 421  RSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGE 480

Query: 403  -QAVSFSTPFGLDSDVDVVMGDPVLLRSVSS-DSLGPPRPAPARTPTQPPPEPG---DLP 457
             +A S      +DS  D+    P+    ++S +++    P  A        E G   + P
Sbjct: 481  EEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETP 540

Query: 458  TIEEALQIIHSAEPRL---LPDGAADGSFYLHSPE----------GPSKPSLASPYLPEG 504
            +IEEALQIIH  E       PD  A+G F+LHS E            S P   +    +G
Sbjct: 541  SIEEALQIIHDTEKSPHTPQPDQIANG-FFLHSQEMSILNSNIKLNQSSPDNVTD--TKG 597

Query: 505  TSKPLSDRP-TKAPVYMPH---PETPSKPSPCL---------VGEASK------------ 539
               P++D       +++P    PET  + S            + +ASK            
Sbjct: 598  ALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNT 657

Query: 540  ----PPAPSEGSPKAVASSPAATNSEVKMTSFAERK-KQLVKAEAEA-GAGSPTSTPAPP 593
                 P PS  S K+   S A+++S VKMTSFAE+K ++L   + ++ G+ S  +TP   
Sbjct: 658  REALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGS 717

Query: 594  EA--------------------------LSSEMSELSARLEEKRRAIEAQKRRIEAIFAK 627
            E                           L+SEM  L  +LEEKRRAIEAQK+++EA F K
Sbjct: 718  ELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTK 777

Query: 628  HRQRLGKSAFLQVQPREASG-------EAEAEAEEADSGPVPGGERPAGEGQG------- 673
             RQ++G++AFL V  ++  G        A AE E+  +      E    +GQ        
Sbjct: 778  QRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADI 837

Query: 674  -EPTSRPKAVTFSPDLGPVPHEG----------------LGEYNRAVSKLSAALSSLQRD 716
             E    P+A        P+  E                 + EY +++ KL+++L  LQ++
Sbjct: 838  KESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQE 897

Query: 717  MQRLTDQQQRLL----------APPEA----------PGSAPPPAAWVIPGPTTGPKAAS 756
            MQRL+ QQ+ L+          +PP+           P      ++ + P  +  P+   
Sbjct: 898  MQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTH 957

Query: 757  PSP--ARRVPAT-----RRSPGPGPSQ-SPRSPKHTRPAELRLAPLTRVLTPPH------ 802
            PSP  + R  A+     +R+P P   + +P +   T P  +   P  R  +P        
Sbjct: 958  PSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTR 1017

Query: 803  -----DVDSLPHLRKFSPSQV-------------------------PVQTRSSILLA--- 829
                   D  P L++  P +                          P ++  S +L+   
Sbjct: 1018 SFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPV 1077

Query: 830  -----------EETPPEEPAARP----------GLIEIPLGSLADPAAEDEGDGSPAGAE 868
                       +   P EP  +P           LIE+ L  L  P   D     P    
Sbjct: 1078 TETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADV----PVEKY 1133

Query: 869  DSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEK 928
            D   ++   + + +V  GFF+KD+ K E++MA KRA+LLE++ RR +E + RKQ  E E 
Sbjct: 1134 DGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEM 1193

Query: 929  EQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQL 988
            E ++EE  R  +EE                    R   E+E   R  +F RQEY RR QL
Sbjct: 1194 EHKKEETRRKTEEE--------------------RQKKEDERARR--EFIRQEYMRRKQL 1231

Query: 989  KLMDDLDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQS 1048
            KLM+D+D V++PR      P    ++  RP+S   D     ++P +G        + S S
Sbjct: 1232 KLMEDMDTVIKPR------PQVVKQKKQRPKSIHRDHIESPKTPIKG------PPVSSLS 1279

Query: 1049 TLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSR--ERDWENGSNASSPASVPE 1106
              SL+T  NE+ ++    + T R+ S  G +SPSR  GSR  E+DWEN S  SS AS  E
Sbjct: 1280 LASLNTGDNESVHS---GKRTPRSESVEGFLSPSRC-GSRNGEKDWENASTTSSVASGTE 1335

Query: 1107 YTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSS 1166
            YTGP+LYKEPSAKSNK II NAL+HCCLAGKVNE QK +ILEE+EKS AN+FLILFRDS 
Sbjct: 1336 YTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILFRDSG 1395

Query: 1167 CQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAF 1226
            CQFR+LYT   ETEE+++L G GP+++T  M+EG+YKYNSDRK+F+ IPAKT+S SVDA 
Sbjct: 1396 CQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSASVDAI 1455

Query: 1227 TIQGHLWQGKKPTTPKK 1243
            TI  HLWQ K+P TPKK
Sbjct: 1456 TIHSHLWQTKRPVTPKK 1472


>gi|186659512 calmodulin regulated spectrin-associated protein 1 [Homo
            sapiens]
          Length = 1602

 Score =  367 bits (941), Expect = e-101
 Identities = 305/903 (33%), Positives = 413/903 (45%), Gaps = 200/903 (22%)

Query: 486  HSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSE 545
            H   G + P + S Y+ E  S  L +   K   +    +   + SPCL            
Sbjct: 750  HDFMGEAHPVVFSRYIGEEESAKLQE-DMKVKEHEDKDDASGRSSPCL------------ 796

Query: 546  GSPKAVASSPAATNSEVKMTSFAERKKQ-LVKAEAEAGAGSPTST--------PAP---- 592
             S  +  SS +  +  VKMTSFAERK Q L   E ++   S   T        PAP    
Sbjct: 797  -STASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKTTPDASESCPAPLTTW 855

Query: 593  ---------------PEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAF 637
                              L+SE+ +L  +LEEKRRAIEAQK+++EA+ A+ R +LGK+AF
Sbjct: 856  RQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKMEALSARQRLKLGKAAF 915

Query: 638  LQVQPR-----------------------EASGEA----------EAEAEEADSGPVPGG 664
            L V  +                       E  G+A          E + EE    P    
Sbjct: 916  LHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVKEEQREELLHEPQDVD 975

Query: 665  ERPAGEGQGEPTSRP------------KAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSS 712
            +      Q      P             A      +G V    + E + ++ KL+  +S+
Sbjct: 976  KESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVD--VNECDLSIEKLNETIST 1033

Query: 713  LQRDMQRLTDQQQRLLAPPEA---PGS--------APPPAAWVIPGPTTG---------- 751
            LQ+ + +++ QQ++LL        PGS           P  +V P   TG          
Sbjct: 1034 LQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLSPTGVAGHRKAPRL 1093

Query: 752  --------------------PKAAS----------------PSPARRVPATRRSPGPGPS 775
                                P+ +S                P PA   P T   PG   +
Sbjct: 1094 GQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSA 1153

Query: 776  QSPRSPKHTR----PAELRLAPLTRVLTPPHDVD--------SLPHLRKFSPSQVPVQTR 823
              P    H +       L      R LT     D        SL  +   S  +V   + 
Sbjct: 1154 LEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEVLDASVKEVG-SSS 1212

Query: 824  SSILLAEETPPEEPA-ARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPR 882
            S +   E  P EEP  +R  LIE+ L  L  P    + DG     + S +    SEG+ +
Sbjct: 1213 SDVSGKESVPVEEPLRSRASLIEVDLSDLKAP----DEDGELVSLDGSAD--LVSEGDQK 1266

Query: 883  VGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEE 942
             G+GFF+KDE K EDE+A+KRA+ L +QQR+AEEAR RKQ  E E E +R+EA R A+E+
Sbjct: 1267 PGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEED 1326

Query: 943  APGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRA 1002
                                R   EEE   R  +  +QEY RR Q +++++         
Sbjct: 1327 --------------------RVRKEEEKARR--ELIKQEYLRRKQQQILEE--------- 1355

Query: 1003 AGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVAN-EAHN 1061
             G G P +   +  RP+S   ++S              LS+  S S+LSL++ A  E  +
Sbjct: 1356 QGLGKP-KSKPKKPRPKSVHREESCSDSGTKCSSTPDNLSRTQSGSSLSLASAATTEPES 1414

Query: 1062 NLGVKRPTSRAPSPSGLMSPSRLPG-SRERDWENGSNASSPASVPEYTGPRLYKEPSAKS 1120
                  P+ R  S   L   SR P  S +RDWE  S ASS ASV EYTGP+L+KEPS+KS
Sbjct: 1415 VHSGGTPSQRVESMEALPILSRNPSRSTDRDWETASAASSLASVAEYTGPKLFKEPSSKS 1474

Query: 1121 NKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETE 1180
            NK IIHNA+SHCCLAGKVNEP KN ILEE+EK  ANH++ILFRD+ CQFRALY    +TE
Sbjct: 1475 NKPIIHNAISHCCLAGKVNEPHKNSILEELEKCDANHYIILFRDAGCQFRALYCYYPDTE 1534

Query: 1181 ELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTT 1240
            E+ +L G GP+ +T  M++ +YKY+SDRK+F  IPAKTMS+SVDA TI  HLWQ K+P  
Sbjct: 1535 EIYKLTGTGPKNITKKMIDKLYKYSSDRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAV 1594

Query: 1241 PKK 1243
            PKK
Sbjct: 1595 PKK 1597



 Score =  245 bits (626), Expect = 2e-64
 Identities = 200/638 (31%), Positives = 299/638 (46%), Gaps = 114/638 (17%)

Query: 2   VEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFY 61
           +EA P G   L     VP    LD+YD +RAK AA+L W+   A+G  +++P +L +PFY
Sbjct: 16  MEAPPDGAADL-----VP----LDRYDAARAKIAANLQWICAKAYG-RDNIPEDLRDPFY 65

Query: 62  TDQYAQEHVKPPVTRLLLSAELYCRAWRQALP--QLETPPNPSALLALLARRGT-VPALP 118
            DQY QEH+KPPV +LLLS+ELYCR     L   Q+       +++  L+R+G  V    
Sbjct: 66  VDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIYVMESD 125

Query: 119 ERPVREADLRHQPILMGAHLAVIDALMAAFAFEW------------------TKTLPGPL 160
           + PV E+DL   PI M AH+A++DALM A+  E                   +K LP   
Sbjct: 126 DTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKELP--- 182

Query: 161 ALTSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRA 220
               LE  ++FW++    +++E TE+E   +          +PA   +RYR++ + AR++
Sbjct: 183 --YDLEDAMVFWINKVNLKMREITEKEVKLKQQLLE-----SPAHQKVRYRREHLSARQS 235

Query: 221 PCFPTVTSL-QDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCAS 279
           P FP +  L +D + GAAL A IH YCP+ ++L+++CLK+  S+ADSLYN++L+++F   
Sbjct: 236 PYFPLLEDLMRDGSDGAALLAVIHYYCPEQMKLDDICLKEVTSMADSLYNIRLLREFSNE 295

Query: 280 RLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPD---------- 329
            L +   L+LED+LY P  LK N++V +AELF  FE +KPDFVQ +D+ +          
Sbjct: 296 YLNKCFYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDVQELKDAKTVLHQ 355

Query: 330 ------------------GHAASPRGTEASPP-----------------QNNSGSSSPVF 354
                             G  A+    E  PP                     G  +  F
Sbjct: 356 KSSRPPVPISNATKRSFLGSPAAGTLAELQPPVQLPAEGCHRHYLHPEEPEYLGKGTAAF 415

Query: 355 TFRHPLL--------SSGGPQSP-LRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAV 405
           +  HPLL        S  G   P  R  + SL          A+  AW  + +RP SQ  
Sbjct: 416 SPSHPLLPLRQKQQKSIQGEDIPDQRHRSNSLTRVDGQPRGAAI--AWPEKKTRPASQPT 473

Query: 406 SFSTPFGLDSDVDVVMGDPV-LLRSVSSDSLG--------PPRPAPARTPTQPPPEPGDL 456
            F+       +VD   GD + L RS+S DSL           +P P  T +       ++
Sbjct: 474 PFALHHAASCEVDPSSGDSISLARSISKDSLASNIVNLTPQNQPHPTATKSHGKSLLSNV 533

Query: 457 PTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLA-SPYLPEGTSKPLSDRPTK 515
              +E  +++      ++P   AD  F   SP      + A SP     TS+   D    
Sbjct: 534 SIEDEEEELVAIVRADVVPQ-QADPEFPRASPRALGLTANARSPQGQLDTSESKPDSFFL 592

Query: 516 APVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVAS 553
            P+ MP    P+K    +  E  +     EG P+++ S
Sbjct: 593 EPL-MPAVLKPAKEKQVITKEDER----GEGRPRSIVS 625


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 147/607 (24%), Positives = 196/607 (32%), Gaps = 120/607 (19%)

Query: 327  LPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHM 386
            LP    AS     A  PQN     + +        S   P  P  G+    K    +SH 
Sbjct: 698  LPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHT 757

Query: 387  EALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTP 446
             AL    +     P   + + +T     +   +      L  SVS  +  PP    +  P
Sbjct: 758  SALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGP 817

Query: 447  TQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSK-----PSLASPYL 501
              P    G+L +    ++     E  L   G+ D     HSP  PS      PS  +P  
Sbjct: 818  DTPI---GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLS 874

Query: 502  PEGTSKPLSDRPTKAPVYMPHPE----TPS-KPSPCLVGEASKP------PAP----SEG 546
            P+G + P  + PT + V +P P+    TP+ K +P L   +S P      PAP    +  
Sbjct: 875  PKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASP 934

Query: 547  SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSAR 606
            SPK   + PAAT    K        K      A A   SP   PA P    +     +  
Sbjct: 935  SPKGAPTPPAATPPSPKGGPATPSPKWAPTPPA-ATPPSPKGGPATPSPKGAPTPPAATP 993

Query: 607  LEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGER 666
               K        +             G      V P    G   A      +   P    
Sbjct: 994  PSPKGGPATPSPK-------------GAPTPPAVTPPSPKGSPAATPFPKGASTPPAATP 1040

Query: 667  PAGEGQGEPTSRPKAVTFSPDLG-PVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQ 725
            P+ +G    T  PK    +P    P P  G                              
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGP----------------------------- 1071

Query: 726  RLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPA-TRRSPGPG----------- 773
               A P   G+  PPAA   P P  GP   SP  A   PA T  SP  G           
Sbjct: 1072 ---ATPSLKGAPTPPAA-TPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPT 1127

Query: 774  -PSQSPRSPKH-----------TRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQ 821
             P+ +P SPK            T PA    +P   + TPP      P     +P+  P  
Sbjct: 1128 TPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPP------PKGAPTTPAATPPS 1181

Query: 822  TRSSILLAEETP---PEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSE 878
             +    LA  +P   P  PAA P     P G LA P        SP GA  +    A++ 
Sbjct: 1182 PKGG--LATPSPKGAPTTPAATP---PSPKGGLATP--------SPKGAPTT---PAATP 1225

Query: 879  GEPRVGL 885
              P+ GL
Sbjct: 1226 PSPKGGL 1232



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 127/569 (22%), Positives = 199/569 (34%), Gaps = 96/569 (16%)

Query: 328  PDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRG-STGSLKSSPSMSHM 386
            P     SP+G  A+PP   +           P   +  P SP  G +T S K +P+    
Sbjct: 1152 PAATPPSPKGGLATPPPKGA-----------PTTPAATPPSPKGGLATPSPKGAPTTP-- 1198

Query: 387  EALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTP 446
             A   +    L+ P  +    +TP          +  P    + ++ +  PP P     P
Sbjct: 1199 AATPPSPKGGLATPSPKGAP-TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG--P 1255

Query: 447  TQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEG-- 504
              PPP+    P          +A P  L  G A         +G   P++ +P  P+G  
Sbjct: 1256 ATPPPKGAPTPP---------AATPPSLKGGLATPPH-----KGAPNPAVVTPPSPKGGP 1301

Query: 505  TSKPLSDRPTKAPVYMPHPE-TPSKPSPCLVGEASKPPAPSEGSPKAVASSPAAT-NSEV 562
             + P    PT      P P+ +P  P P     A  PPA +  SPK   + PA T +S+ 
Sbjct: 1302 ATSPPKGAPTPPAATPPSPKGSPGTPPP---KGAPTPPAVTPPSPKGTPTLPATTPSSKG 1358

Query: 563  KMTSFAERKKQLVKAEAEAGAGSPTSTPAPPE---ALSSEMSELS--ARLEEKRRAIEAQ 617
              T+ + ++     A   +  G P  TP  P+   A+ S   + +  A +    +   A 
Sbjct: 1359 GPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPAT 1418

Query: 618  KRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEG------ 671
                E      +  L   A   V  ++A          A S P  G   P+ +G      
Sbjct: 1419 PVTREGAATPSKGDLTPPAVTPVSLKKA---------PATSAPKGGPATPSSKGDPTLPA 1469

Query: 672  ------QGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQ 725
                  +  P  +  A + SP   P     +G        L A + S  +++      ++
Sbjct: 1470 VTPPSPKEPPAPKQVATSSSPKKAPATPAPMG-----APTLPAVIPSSPKEVPATPSSRR 1524

Query: 726  RLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPG-PGPSQSP------ 778
              +AP     S   PA       T  PK A   PA  VP+ +++P  P P ++P      
Sbjct: 1525 DPIAPTATLLSKKTPA-------TLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSK 1577

Query: 779  --RSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEE 836
               SP    P+  + AP  + L  P      P +   SP + P              PE+
Sbjct: 1578 EASSPPAVTPSTYKGAPSPKELLIP------PAVTSPSPKEAPTPP-----AVTPPSPEK 1626

Query: 837  PAARPGLIEIPLGSLADPAAEDEGDGSPA 865
              A P     P      P++  +   SPA
Sbjct: 1627 GPATPAPKGTPTSPPVTPSSLKDSPTSPA 1655



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 154/645 (23%), Positives = 209/645 (32%), Gaps = 141/645 (21%)

Query: 286  PLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAASPRGTEASPPQN 345
            P + E+    P P   N    LA L +  E+  P  V    LP   A +P GT+     +
Sbjct: 702  PTASENCPVAPSPQ--NTCAPLATLVLAPEI--PKSVPSPSLPP--AGTPPGTKKVDGIS 755

Query: 346  NSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLK---SSPSMSHMEALGKAWNRQLSRPLS 402
            ++ + +PV +      +     S    S G+L     SPS      LG + + Q  RP +
Sbjct: 756  HTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPS-----PLGVSVSPQTKRPPT 810

Query: 403  QAVSFS--TPFG-LDSDVDVVMGDPVLLRSVS----------SDSLGPPRPAPARTPTQ- 448
            +  S    TP G L S V  V    +   S+S          + S  PP P  A TP+  
Sbjct: 811  KKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAV 870

Query: 449  ---------------PPPEPGDLPTIEE-----------ALQIIHSAEPRLLPDGAADGS 482
                           P P   +LP  +E           AL +  S+  +     A  G 
Sbjct: 871  TPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGI 930

Query: 483  FYLHSPEGPSKPSLASPYLPEGTSKPLSDR--PTKAPVYMPHPET-PSKPSPCLVGEASK 539
                SP+G   P  A+P  P+G     S +  PT      P P+  P+ PSP     A  
Sbjct: 931  PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSP---KGAPT 987

Query: 540  PPAPSEGSPKA-------------VASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSP 586
            PPA +  SPK               A +P +       T F +       A   +  GSP
Sbjct: 988  PPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSP 1047

Query: 587  TSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREAS 646
             +TP P  A ++  + L                                      P    
Sbjct: 1048 AATPLPKGAPTTPAATL--------------------------------------PSPKG 1069

Query: 647  GEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSP-DLGPVPHEGLGEYNRAVSK 705
            G A    + A   P P    P     G  T  PK     P    P P  GL       + 
Sbjct: 1070 GPATPSLKGA---PTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP 1126

Query: 706  LSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTG-----PKAASPSPA 760
             + A +            +  L  PP  P  AP   A   P P  G     PK A  +PA
Sbjct: 1127 TTPAATP--------PSPKGGLATPP--PKGAPTTPAATPPSPKGGLATPPPKGAPTTPA 1176

Query: 761  RRVPATRRS-PGPGPSQSPRSPKHTRPA--------ELRLAPLTRVLTPPHDVDSLPHLR 811
               P+ +     P P  +P +P  T P+          + AP T   TPP     L    
Sbjct: 1177 ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPS 1236

Query: 812  KFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIP--LGSLADP 854
                   P  T  S      TPP + A  P     P   G LA P
Sbjct: 1237 PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATP 1281



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 139/567 (24%), Positives = 187/567 (32%), Gaps = 66/567 (11%)

Query: 330  GHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEAL 389
            G   SP  T +  P +  G+ +P         S+  P SP +G T   K +P+ S +   
Sbjct: 845  GSKDSPATTHSPTPPSPKGAPTP---------SAVTPLSP-KGVTLPPKETPTPSVVNLP 894

Query: 390  GKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQP 449
                      P  QA + S          +    P   R+  +    P  P+P   PT P
Sbjct: 895  FPKEGPATPAP-KQAPALS----------MTSSSPKKARATPAPKGIPASPSPKGAPTPP 943

Query: 450  ---PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTS 506
               PP P   P          +  P      +  G     SP+G   P  A+P  P+G  
Sbjct: 944  AATPPSPKGGPATPSPKW---APTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGP 1000

Query: 507  KPLSDR--PTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKM 564
               S +  PT   V  P P+     +P   G AS PPA +  SPK    SPAAT     +
Sbjct: 1001 ATPSPKGAPTPPAVTPPSPKGSPAATPFPKG-ASTPPAATPPSPKG---SPAAT----PL 1052

Query: 565  TSFAERKKQLVKAEAEAGAGSPT--STPAPPEALSSEMSELSARLEEKRRAIE--AQKRR 620
               A           + G  +P+    P PP A         A    K   +   A    
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS 1112

Query: 621  IEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPK 680
             +   A    +   +      P    G A    + A + P      P G   G  T  PK
Sbjct: 1113 PKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG---GLATPPPK 1169

Query: 681  AVTFSPDLGPV-PHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPP 739
                +P   P  P  GL   +   +  + A +             +  LA P   G+   
Sbjct: 1170 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATP---------PSPKGGLATPSPKGAPTT 1220

Query: 740  PAAWVIPGPTTGPKAASPSPARRVP-ATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVL 798
            PAA   P P  G    SP  A   P AT  SP  GP+  P     T PA    +    + 
Sbjct: 1221 PAA-TPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLA 1279

Query: 799  TPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP----PEEPAARPGLIEIPLGSLADP 854
            TPPH     P+    +P        +S      TP    P  P   PG    P G+   P
Sbjct: 1280 TPPH--KGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPG-TPPPKGAPTPP 1336

Query: 855  AAEDEGDGSPAGAEDSLEEEASSEGEP 881
            A       SP G         SS+G P
Sbjct: 1337 AVTPP---SPKGTPTLPATTPSSKGGP 1360



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 136/584 (23%), Positives = 193/584 (33%), Gaps = 144/584 (24%)

Query: 334  SPRGTEASP------------PQNNSGSSSPVFTFRHPLLSSGGPQSPLRG-STGSLKSS 380
            SP+GT   P            P +  G + P  T  H    +  P SP RG +  S K  
Sbjct: 1342 SPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGD 1401

Query: 381  PSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGD-------PVLLRSVSSD 433
            P+   +             PLS   + +TP   +       GD       PV L+   + 
Sbjct: 1402 PTSPAVI------------PLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPAT 1449

Query: 434  SL---GPPRPAPARTPTQP---PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHS 487
            S    GP  P+    PT P   PP P + P  +   Q+  S+ P+  P   A        
Sbjct: 1450 SAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPK---QVATSSSPKKAPATPA-------- 1498

Query: 488  PEG-PSKPSLASPYLPEGTSKPLSDRPTKAPVY-MPHPETPSKPSPCLVGEASKPPAPSE 545
            P G P+ P++      E  + P S R   AP   +   +TP+  +P    EA  PPA + 
Sbjct: 1499 PMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAP---KEALIPPAMTV 1555

Query: 546  GSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSA 605
             SPK   + P    +    +S        V      GA SP     PP   S        
Sbjct: 1556 PSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPS------ 1609

Query: 606  RLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGE 665
                                                P+EA              P P   
Sbjct: 1610 ------------------------------------PKEA--------------PTPPAV 1619

Query: 666  RPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVS-KLSAALSSLQRDM---QRLT 721
             P    +G  T  PK    SP + P   +       +V+ K+ A +    + +   +  T
Sbjct: 1620 TPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPT 1679

Query: 722  DQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRR-SPGPGPSQSPR- 779
              ++ L+AP  AP S P   A    GP T   +A+  P    P+ +  S GP  + +P  
Sbjct: 1680 ALKEVLVAP--APESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAP 1737

Query: 780  -------SPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEET 832
                   S K  +  +   +P    L PP    S P         +P    +S+  A   
Sbjct: 1738 LLPVQKDSSKTAKGKDASHSP-KGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSP 1796

Query: 833  PPEEPAA----------------RPGLI-EIPLGSLADPAAEDE 859
            P   P A                 PGL+ E P   LA PA EDE
Sbjct: 1797 PVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLA-PADEDE 1839


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 128/516 (24%), Positives = 178/516 (34%), Gaps = 111/516 (21%)

Query: 437 PPRPAPARTPTQPPPE-------PGDLPT--IEEALQIIHSAE----------------P 471
           P  P P  +PT PPPE       P +LP   + EAL +    E                P
Sbjct: 448 PLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPP 507

Query: 472 RLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSP 531
              P    + S      E P  P+L +P  P   + PLS    ++P+  P  E P+ P P
Sbjct: 508 ESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPP 567

Query: 532 CLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTP- 590
               EAS+   P E SP    S P     E  M+   E  +     E    +  P  +P 
Sbjct: 568 ----EASRLSPPPEESP---MSPPP---EESPMSPPPEASRLFPPFEESPLSPPPEESPL 617

Query: 591 -APPEAL----SSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREA 645
             PPEA       E S +S   EE   +   +  R+  +    R          + P   
Sbjct: 618 SPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSR----------LSPPPE 667

Query: 646 SGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSK 705
                   EE+ + P P   R +   +  PTS P          P P + L     ++  
Sbjct: 668 ESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPE---DSPASPPPEDSL----MSLPL 720

Query: 706 LSAALSSLQRDMQRLTDQQQRLLAP-PEAPGSAPPPAAWVIPGPTTGPKAASP--SPARR 762
             + L  L  + Q     +   L+P PE P  +P P       P   P+A  P  SP   
Sbjct: 721 EESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEE-----PHLSPQAEEPHLSPQPE 775

Query: 763 VPATRRSP--------GPGPSQSPRSPKHTRPAELRLAPLTR-----------VLTP-PH 802
            P     P          GP  SP      +P EL L+P T             L+P P 
Sbjct: 776 EPCLCAVPEEPHLSPQAEGPHLSP------QPEELHLSPQTEEPHLSPVPEEPCLSPQPE 829

Query: 803 DVDSLPHLRKFSPSQVPVQTRSSILLAE-------ETPPEEPAARPGLIEIPL------- 848
           +    P   +   S  P ++  S  L +       E PPEEP   P   E+PL       
Sbjct: 830 ESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEP 889

Query: 849 ---GSLADPAAEDEGDGSPAGAEDSLEEEASSEGEP 881
                L +PA  + G+   +   + L    S  GEP
Sbjct: 890 SLSPLLGEPALSEPGEPPLSPLPEEL--PLSPSGEP 923



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 147/603 (24%), Positives = 205/603 (33%), Gaps = 99/603 (16%)

Query: 319  PDFVQVKDLPDGHAASPRGTEA--SPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGS 376
            P+ +     P+    SP   E+  SPP   S  S P    R   L     +SPL      
Sbjct: 558  PEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASR---LFPPFEESPLSPPPEE 614

Query: 377  LKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLG 436
               SP            +  +S P  ++     P     +V  +   PV+ R        
Sbjct: 615  SPLSPPPEASRLSPPPEDSPMSPPPEES-----PMSPPPEVSRLSPLPVVSRLSPPPEES 669

Query: 437  PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
            P  P P  +PT PPPE   L    E        E         D    L   E P  P  
Sbjct: 670  PLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLP 729

Query: 497  ASPYL-PEGTSKPLSDRPTKAPVYMPHPE-------------TPSKPSPCLVGEASKPPA 542
              P L P      LS RP + P   P PE             +P    PCL     +P  
Sbjct: 730  EEPQLCPRSEGPHLSPRPEE-PHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHL 788

Query: 543  PSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSE 602
                SP+A     +    E+ ++   E        E       P  +P P E+  S  SE
Sbjct: 789  ----SPQAEGPHLSPQPEELHLSPQTEEPHLSPVPE------EPCLSPQPEESHLSPQSE 838

Query: 603  ---LSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAF-----LQVQPREAS-----GE- 648
               LS R EE   + E +K  +     K  +  G+        L   P E S     GE 
Sbjct: 839  EPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEP 898

Query: 649  AEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSA 708
            A +E  E    P+P  E P     GEP+  P+ +   PD  P P   +     A     +
Sbjct: 899  ALSEPGEPPLSPLPE-ELPLSPS-GEPSLSPQLMP--PDPLPPPLSPI--ITAAAPPALS 952

Query: 709  ALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRR 768
             L  L+       D        PE+P +AP     ++  P + P  A+ +    VP    
Sbjct: 953  PLGELEYPFGAKGDSD------PESPLAAP-----ILETPISPPPEANCTDPEPVPPMIL 1001

Query: 769  SPGPGPSQSPRSPKHTRPAELRLAPLTR-VLTPPHDVDSLPHLRKFSPSQVPVQTRSSIL 827
             P PG    P SP    P   + +PL +  L P +   S     + SP  +P+   S + 
Sbjct: 1002 PPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPS-----QCSPPALPLSVPSPLS 1056

Query: 828  -------LAEE-----------TPPEEPAARPGL---IEIPLGSLADPAAEDEGDGSPAG 866
                   +++E           + PE PA  P     +  P+G L+ PA       SPA 
Sbjct: 1057 PIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAP------SPAP 1110

Query: 867  AED 869
            A D
Sbjct: 1111 ALD 1113



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 107/429 (24%), Positives = 145/429 (33%), Gaps = 103/429 (24%)

Query: 450 PPEPGDLPTIE-EALQIIHSAEPR------------------LLPDGAADGSF--YLHSP 488
           PPEPGD PT E +AL +    +P+                    P G A       L +P
Sbjct: 374 PPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAP 433

Query: 489 EGPSKPSL----ASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPS 544
                P L     SP  P     P S  P  + +  P  E P+ P P    EA     P 
Sbjct: 434 LNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLP----EALHLSRPL 489

Query: 545 EGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELS 604
           E SP +     +  +   + + F+  ++  +    E+       TP  P     E S LS
Sbjct: 490 EESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSP---PPEASPLS 546

Query: 605 ARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGG 664
              EE   +   ++                   L   P   +       EE+   P P  
Sbjct: 547 PPFEESPLSPPPEE-------------------LPTSPPPEASRLSPPPEESPMSPPP-- 585

Query: 665 ERPAGEGQGEPTSRPKAVT--FSP----DLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQ 718
                  +  P S P   +  F P     L P P E         S LS           
Sbjct: 586 -------EESPMSPPPEASRLFPPFEESPLSPPPEE---------SPLSP---------- 619

Query: 719 RLTDQQQRLLAPPE-APGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSP-GPGPSQ 776
               +  RL  PPE +P S PP  + + P P     +  P  +R  P    SP  P P +
Sbjct: 620 --PPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEE 677

Query: 777 SPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP--- 833
           SP SP    P   RL+P      PP D  + P   + SP+  P +     L  EE+P   
Sbjct: 678 SPTSPP---PEASRLSP------PPEDSPTSPP-PEDSPASPPPEDSLMSLPLEESPLLP 727

Query: 834 -PEEPAARP 841
            PEEP   P
Sbjct: 728 LPEEPQLCP 736



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 99/451 (21%), Positives = 158/451 (35%), Gaps = 111/451 (24%)

Query: 438  PRPAPARTPTQPPPE-PGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
            P+P P+    QPP   PG     ++ + ++H+A       G + G        G S  + 
Sbjct: 4082 PQPQPSSLQLQPPLRLPGQQ---QQQVSLLHTA------GGGSHGQL----GSGSSSEAS 4128

Query: 497  ASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPA 556
            + P+L    S  L D+P      +  P+ P    P       +PP P             
Sbjct: 4129 SVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPG------------ 4176

Query: 557  ATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEA-LSSEMSELSARLEEKRRAIE 615
                                   ++G G P     P    L +++  + A+  + R    
Sbjct: 4177 --------------------PVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSP 4216

Query: 616  AQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAE-----EADSGPVPG------- 663
             Q+++++A+  + RQ     A  Q  P +  G   +  +     +   G  PG       
Sbjct: 4217 QQQQQLQALLMQ-RQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQ 4275

Query: 664  --GERPAGEGQGEPTSRPKAVTFSPDLGPV---PHEGLGEYNRAVSKLSAALSSLQRDMQ 718
              G  P  +G     + P A++  P LGPV   P     +  +  S+L +  S L  + Q
Sbjct: 4276 ELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQ 4335

Query: 719  RLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSP-ARRVPATRRSPGPGPSQS 777
                       PP  PG+  P       GPT  P     SP A ++  T  S G GP   
Sbjct: 4336 ----------LPPTHPGTPKP------QGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDP 4379

Query: 778  PRSPKHT-RPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEE 836
            P +   T +P +  L P               HL + +   VP  ++ SI   ++ P EE
Sbjct: 4380 PDNLAETQKPEQSSLVP--------------GHLDQVNGQVVPEASQLSI---KQEPREE 4422

Query: 837  PAARPGLIEIPLGSLADPAAEDEGDGSPAGA 867
            P A           L   + + E +G P GA
Sbjct: 4423 PCA-----------LGAQSVKREANGEPIGA 4442



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 60/227 (26%), Positives = 80/227 (35%), Gaps = 45/227 (19%)

Query: 342  PPQNNSGSSSPVFTFRHPLLSSGG--PQSPLRGSTGSLKS--------SPSMSHM----- 386
            P QNN+G   P      P+L SG   P   +  + G L++        +P + H+     
Sbjct: 4163 PMQNNTGPQPPK---PGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQ 4219

Query: 387  ---EALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPA 443
               +AL      Q S+ + Q   +  P    S +  ++G    L        GP +   A
Sbjct: 4220 QQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGA 4279

Query: 444  RTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPE 503
                Q PP    LP    AL    S  P L P         +H    PS P    P  P 
Sbjct: 4280 GPRPQGPPR---LPAPPGAL----STGPVLGP---------VHPTPPPSSPQ--EPKRPS 4321

Query: 504  GTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKA 550
                P S  PT+A +   HP TP    P L       P P   SP A
Sbjct: 4322 QLPSPSSQLPTEAQLPPTHPGTPKPQGPTL------EPPPGRVSPAA 4362



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 145/695 (20%), Positives = 232/695 (33%), Gaps = 109/695 (15%)

Query: 435  LGPPRPAPARTPTQPPPEPGDL----PTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEG 490
            L P  P PA+     PP   D+       +   Q   +  P+  P  +         P  
Sbjct: 2347 LRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSD 2406

Query: 491  PSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPA-PSEGSPK 549
            P     ASP     +  PL+ RP  A  + P P TP   SP      S+PP+ P    P 
Sbjct: 2407 PFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSP---DPYSRPPSRPQSRDPF 2463

Query: 550  AVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEE 609
            A    P       +    A +   L      AG G P + PA P        EL A++  
Sbjct: 2464 APLHKP----PRPQPPEVAFKAGSLAHTSLGAG-GFPAALPAGP------AGELHAKVPS 2512

Query: 610  KRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAG 669
             +     +     A        +G  + ++    +A GE   +      G  P     + 
Sbjct: 2513 GQPPNFVRSPGTGAF-------VGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSH 2565

Query: 670  EGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLA 729
             G G    +P++  ++           G ++ + S L  +  S          +   +L 
Sbjct: 2566 FGPGPTLGKPQSTNYT--------VATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLP 2617

Query: 730  PPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAEL 789
            PP   GS P    ++  G     ++   SP  +    R  PG G   S  + +     + 
Sbjct: 2618 PPAPDGSLP----YLSHG--ASQRSGITSPVEK----REDPGTGMGSSLATAELPGTQDP 2667

Query: 790  RLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLG 849
             ++ L++      +++     ++     +  Q + + L  E+   E  AA  G +  P  
Sbjct: 2668 GMSGLSQT-----ELEKQRQRQRLRELLIRQQIQRNTLRQEK---ETAAAAAGAVGPPGS 2719

Query: 850  SLADPAAE-----DEGDGSPAGAEDS---LEEEASSEGEPRVGLGFFYKDE--DKPEDEM 899
              A+P++        G    AG +D    +    S    P +G G F  D+   +P    
Sbjct: 2720 WGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPA 2779

Query: 900  AQKRASLLERQ---------QRRAEEARRRKQWQEVEKEQRREEAARLAQEEA------- 943
                  +  RQ         QR         Q Q+ +  Q+++  A  +   A       
Sbjct: 2780 TPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPS 2839

Query: 944  -PGP--------APLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDL 994
             PGP        +PL     ++T  P    P     GP +             ++L  ++
Sbjct: 2840 TPGPELGRQALGSPLAG---ISTRLPGPGEPVPGPAGPAQ------------FIELRHNV 2884

Query: 995  DKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLST 1054
             K L P   G+  PG+G  +  R      D   LA    RGL  S L      S      
Sbjct: 2885 QKGLGP--GGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPP-QKPSAPPAPE 2941

Query: 1055 VANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSRE 1089
            + N  H     K PT     P+GL   +R P S E
Sbjct: 2942 LNNSLHPTPHTKGPT----LPTGLELVNRPPSSTE 2972



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 94/373 (25%), Positives = 127/373 (34%), Gaps = 51/373 (13%)

Query: 342  PPQNNSGSSSPVFTFRHPLL--SSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSR 399
            PP+ N     PV     P    S  GP SP+       + SP + H      +   Q S 
Sbjct: 985  PPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSP 1044

Query: 400  PLSQAVSFSTPFGLDSDVDVV-MGDPVLLRSVSSDSLGPPR-PAPARTPTQPPPEP-GDL 456
            P   A+  S P  L     VV + D   L  + ++ +  P  PA   + T P P P GDL
Sbjct: 1045 P---ALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDL 1101

Query: 457  ----PTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDR 512
                P+   AL           P    D       P G +  SLAS       S  L D 
Sbjct: 1102 SCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEP-GQTPGSLASELKG---SPVLLDP 1157

Query: 513  PTKAPV-----YMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSF 567
               APV     Y    +T  + SPC   E  +P AP   +P  +  S     +E+   S 
Sbjct: 1158 EELAPVTPMEVYPECKQTAGQGSPC--EEQEEPRAPVAPTPPTLIKSDIV--NEISNLS- 1212

Query: 568  AERKKQLVKAEAEAGAGSPTSTPA----PPEALSSEMSELSARLEEKRRAIEAQKRRIEA 623
                      + +A A  P S P      PE   S   EL    +      E   R    
Sbjct: 1213 ----------QGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTD 1262

Query: 624  IFAKHRQRLGKSAFLQVQPREASGE--------AEAEAEEADSGPVPGGERPAG---EGQ 672
               +    L   A   +   +A GE        A +  ++  S   PG  RP G    G+
Sbjct: 1263 SLPETDDSLLCDAGTAISGGKAEGEKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGR 1322

Query: 673  GEPTSRPKAVTFS 685
            G   +R K+   S
Sbjct: 1323 GRGRARLKSTASS 1335



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 97/466 (20%), Positives = 157/466 (33%), Gaps = 83/466 (17%)

Query: 477  GAADGSFYLHSPEGPSKPSLA-SPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVG 535
            G  + S  L SP+   +  +A  P +P    +  S      P  +   +  +   P +  
Sbjct: 3976 GLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSS 4035

Query: 536  EASKPPAPSEGSPKAVASSP---AATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA- 591
            EA++ P+  +G P A+ ++P   A    EVK +   + +  LV+ + +     P+S    
Sbjct: 4036 EATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQP---QPSSLQLQ 4092

Query: 592  PPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEA 651
            PP  L  +  +  + L         Q      + +           L  QP  + G+   
Sbjct: 4093 PPLRLPGQQQQQVSLLHTAGGGSHGQ------LGSGSSSEASSVPHLLAQPSVSLGDQPG 4146

Query: 652  EAEEADSGPV-PGGERPAGEGQGEPTSRPKAVTFS----PDLGPVPHEG-LGEYNRAVSK 705
               +   GP  P  ERP     G    +P  V  S    P +G +P  G L    + V  
Sbjct: 4147 SMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLA 4206

Query: 706  LSAALSSL----QRDMQRLTDQQQ-------RLLAP------------------------ 730
             +  L  L    Q+ +Q L  Q+Q       R   P                        
Sbjct: 4207 KNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF 4266

Query: 731  ----------------PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGP 774
                            P+ P   P P   +  GP  GP   +P P+      R      P
Sbjct: 4267 PGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKR------P 4320

Query: 775  SQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPP 834
            SQ P SP    P E +L P       P      P   + SP+   +   +  L ++   P
Sbjct: 4321 SQLP-SPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQL---ADTLFSKGLGP 4376

Query: 835  EEPAARPGLIEIPLGSLADPAAEDEGDGS--PAGAEDSLEEEASSE 878
             +P       + P  S   P   D+ +G   P  ++ S+++E   E
Sbjct: 4377 WDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREE 4422



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 102/466 (21%), Positives = 147/466 (31%), Gaps = 91/466 (19%)

Query: 450  PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPL 509
            PP+PG L +   A      A P +        +    S +G  KP   S   P+   +  
Sbjct: 2107 PPQPGALGSPPPA------AAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELF 2160

Query: 510  SDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAE 569
               P + P  +P  + P   +P    E   P AP    P      P+ T         A 
Sbjct: 2161 LKLPPQVPAQVPSQD-PFGLAPAYPLEPRFPTAPPTYPPY-----PSPTG--------AP 2206

Query: 570  RKKQLVKAEAEAGAGSPTST-PAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKH 628
             +  ++ A +  GAG P      PP     + S     L+ +  +++             
Sbjct: 2207 AQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLD------------- 2253

Query: 629  RQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGE-RPAGEGQGEPTSRPKAVTFSPD 687
                       +   E+ G    +A E    P P GE R A E + E           P+
Sbjct: 2254 ----------NLAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPN 2303

Query: 688  LGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPG-----SAPPPAA 742
            LG V     G +          L     D+ +     +     P++PG       PPPA 
Sbjct: 2304 LGFVDSPSSGTH-------LGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQ 2356

Query: 743  WVIPGPTTGPKAASP----SPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVL 798
             + P P + P    P     P  + P T R   P P      P  + P++    P +RV 
Sbjct: 2357 ALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSD----PFSRVP 2412

Query: 799  TPPHDVDSLP--------HLRKFSPSQVPVQTRSSILLAEETPPEEPAAR---------- 840
              P    S              F PS  PV  R         PP  P +R          
Sbjct: 2413 ASPQSQSSSQSPLTPRPLSAEAFCPS--PVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPP 2470

Query: 841  ---PGLIEIPLGSLADPAAEDEG--DGSPAGAEDSLEEEASSEGEP 881
               P  +    GSLA  +    G     PAG    L  +  S G+P
Sbjct: 2471 RPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPS-GQP 2515



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 47/220 (21%), Positives = 77/220 (35%), Gaps = 27/220 (12%)

Query: 890  KDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPL 949
            + + K + ++ Q R    E     AE   +++Q Q+ +++Q+++ +A LA   +  P  L
Sbjct: 3569 EQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLL 3628

Query: 950  VSAVPMATPA----PAARAPAEEEVGPRK------------GDFTRQEYERRAQLKLMDD 993
                    P     P    P  +  G R             G F      ++ Q +    
Sbjct: 3629 TKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMALPGQPGGPFLNTALAQQQQQQHSGG 3688

Query: 994  LDKVLRPRAAGSGG--PGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQST-- 1049
               +  P    SGG  PG    R+  P S    +  L     R  L  +L +   Q    
Sbjct: 3689 AGSLAGP----SGGFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQ 3744

Query: 1050 ---LSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPG 1086
               L    +  +     GV+   +  P P GLM PS   G
Sbjct: 3745 QHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQG 3784



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 71/296 (23%), Positives = 101/296 (34%), Gaps = 71/296 (23%)

Query: 300  KVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHP 359
            ++N V   AE  +  +    D  +  D P  H   P      P     GS  P      P
Sbjct: 2072 RINKVQKQAESQINKQTKVGDIARKTDRPALHLRIP------PQPGALGSPPPAAA---P 2122

Query: 360  LLSSGGPQSPLRGST---GSLKS-SPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDS 415
             +  G P +P   ST   G LK  + S+   ++ G+ + + L   +   V    PFGL  
Sbjct: 2123 TIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLK-LPPQVPAQVPSQDPFGL-- 2179

Query: 416  DVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLP 475
                    P+  R  ++    PP P+P   P QPP               +  A  R  P
Sbjct: 2180 ----APAYPLEPRFPTAPPTYPPYPSPTGAPAQPP---------------MLGASSR--P 2218

Query: 476  DGAADGSFYLHSPEGP-SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLV 534
                 G F+   P  P  +PS   P+L                     P  PS      +
Sbjct: 2219 GAGQPGEFHTTPPGTPRHQPSTPDPFL--------------------KPRCPS------L 2252

Query: 535  GEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTP 590
               + P +P  G  K  AS P      +    F E +K L   + E GA SP+  P
Sbjct: 2253 DNLAVPESPGVGGGK--ASEPL-----LSPPPFGESRKALEVKKEELGASSPSYGP 2301



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 44/154 (28%), Positives = 55/154 (35%), Gaps = 19/154 (12%)

Query: 732 EAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAE--- 788
           E P   PP  + + P P   P +  P  +R  P     P    S  P +   +RP E   
Sbjct: 437 EMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPA---SPLPEALHLSRPLEESP 493

Query: 789 LRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPL 848
           L   P    L+PP      P    FSP +      S +   EE+PP  PA    L   P 
Sbjct: 494 LSPPPEESPLSPP------PESSPFSPLE-----ESPLSPPEESPP-SPALETPLSPPPE 541

Query: 849 GS-LADPAAEDEGDGSPAGAEDSLEEEASSEGEP 881
            S L+ P  E      P     S   EAS    P
Sbjct: 542 ASPLSPPFEESPLSPPPEELPTSPPPEASRLSPP 575



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 47/172 (27%), Positives = 58/172 (33%), Gaps = 33/172 (19%)

Query: 716  DMQRLTDQQQRLLAPPEAPGS--APPPAAW---VIPGPTTGPKAASPSPARRVPATRRSP 770
            D+ R TD+    L  P  PG+  +PPPAA     I  PTT    ++ +     P     P
Sbjct: 2092 DIARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVP 2151

Query: 771  GPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAE 830
            GP             P EL L        PP             P+QVP Q    +  A 
Sbjct: 2152 GPDS-----------PGELFLK------LPPQ-----------VPAQVPSQDPFGLAPAY 2183

Query: 831  ETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPR 882
               P  P A P     P  + A       G  S  GA    E   +  G PR
Sbjct: 2184 PLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPR 2235



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 43/155 (27%), Positives = 55/155 (35%), Gaps = 18/155 (11%)

Query: 330  GHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEAL 389
            G    P+G    P    + S+ PV    HP      PQ P R S   L S  S    EA 
Sbjct: 4278 GAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPS--QLPSPSSQLPTEAQ 4335

Query: 390  GKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQP 449
                +    +P  Q  +   P G  S     + D     ++ S  LGP  P      TQ 
Sbjct: 4336 LPPTHPGTPKP--QGPTLEPPPGRVSPAAAQLAD-----TLFSKGLGPWDPPDNLAETQK 4388

Query: 450  PPE----PGDL-----PTIEEALQIIHSAEPRLLP 475
            P +    PG L       + EA Q+    EPR  P
Sbjct: 4389 PEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEP 4423



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 21/65 (32%), Positives = 24/65 (36%), Gaps = 5/65 (7%)

Query: 722  DQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSP 781
            D +Q    PPE P   P P A     P T P    P+     P     P P P     SP
Sbjct: 4902 DVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEP-----PVPSPLPLASSP 4956

Query: 782  KHTRP 786
            +  RP
Sbjct: 4957 ESARP 4961



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query: 938  LAQEEAPGPAPLVSAVPMATPAPAARAPAEEE 969
            LA+   P P PL S+   A P P AR P E E
Sbjct: 4941 LAEPPVPSPLPLASSPESARPKPRARPPEEGE 4972



 Score = 30.8 bits (68), Expect = 8.4
 Identities = 15/86 (17%), Positives = 47/86 (54%), Gaps = 1/86 (1%)

Query: 857  EDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEE 916
            + +  GS AG     +   S  G+P++        +   + +  Q++  L ++QQ++ ++
Sbjct: 3863 QHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQ 3922

Query: 917  ARRRKQWQEVEKEQRREEAARLAQEE 942
             ++ +Q Q+++++Q++++  +  Q++
Sbjct: 3923 QQQLQQ-QQLQQQQQQQQLQQQQQQQ 3947


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 112/546 (20%), Positives = 206/546 (37%), Gaps = 56/546 (10%)

Query: 511  DRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAER 570
            +  TK+P       +P K +   V E +K PA ++   K  A SPA   S  K  S A+ 
Sbjct: 498  EEETKSPP-AEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556

Query: 571  KKQL---VKAEAEAGAGSPTSTPAPPEALSSEMSE----LSARLEEKRRAIEAQKRRIEA 623
            + +     K+  +  A SP    +P +A S    E      A+  EK ++   ++ +  A
Sbjct: 557  EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616

Query: 624  IFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVT 683
                  +   KS      P +A    + EA+  +    P  E+   +   +  S  KA  
Sbjct: 617  EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP--EKEEAKSPEKAKSPVKAEA 674

Query: 684  FSPDLGPVPHEGLGEY-NRAVSKLSAALSSLQRDMQRLTDQ---QQRLLAPPEAPGSAPP 739
             SP+    P +   +   +A S +     S ++    + ++    ++  +P +     P 
Sbjct: 675  KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734

Query: 740  PAAWVIPGPTTGP-KAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVL 798
             A   +      P KA SP  A+ +            +  RSP    P + +      V 
Sbjct: 735  KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794

Query: 799  TPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAED 858
            +P      L    K    ++P +      + EE  P+         E+ +      A E+
Sbjct: 795  SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ---------EVKVKEPPKKAEEE 845

Query: 859  EGDGSPAGAE--DSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAE- 915
            +   +P   E  DS +EEA  +  P+       K E+K E  + + + S +E ++  AE 
Sbjct: 846  KAPATPKTEEKKDSKKEEAPKKEAPKP------KVEEKKEPAVEKPKESKVEAKKEEAED 899

Query: 916  ---------EARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPA 966
                     EA  + + +E  K + + E A+   ++A    P       + PA    A A
Sbjct: 900  KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP-------SKPAEKKEA-A 951

Query: 967  EEEVGPRKGDFTRQEYERRAQLKLMDDLDKVL-----RPRAAGSGGPGRGGRRATRPRSG 1021
             E+   ++    + E + + + K  +D DK L     +P+A  +       ++ ++P   
Sbjct: 952  PEKKDTKEEKAKKPEEKPKTEAKAKED-DKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010

Query: 1022 CCDDSA 1027
              +D A
Sbjct: 1011 ATEDKA 1016



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 95/412 (23%), Positives = 157/412 (38%), Gaps = 48/412 (11%)

Query: 568 AERKKQLVKAEAEAGAGS-PTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFA 626
           A  +K L   E   G G  P S P     + S  + +  + EEK + +E  ++  E +  
Sbjct: 400 AAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEK--ETVIV 457

Query: 627 KHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSP 686
           +      ++   QV   E + E E EA+E +     GGE    EG  E T  P A     
Sbjct: 458 EE-----QTEETQV-TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPA----- 506

Query: 687 DLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIP 746
                  E       A S +     S   + +    ++ +  A  ++P  A  PA     
Sbjct: 507 ------EEAASPEKEAKSPVKEEAKS-PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559

Query: 747 GPTTGPKAASPSPAR-RVPATRRSPGPGPS---QSPRSPKHTRPAELRLAPLTRVLTPPH 802
            P   P+A SP     + PA  +SP    S   +  +SP   +  E   +P+      P 
Sbjct: 560 SP---PEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616

Query: 803 DVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDG 862
           +  S       SP++V    ++     EE    E A  P               E E   
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP---------------EKEEAK 661

Query: 863 SPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQ 922
           SP  A+  ++ EA S  + +  +    K  +K +  + ++  S  + +    EEA+  ++
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721

Query: 923 WQEVEKEQRR--EEAARLAQEEAPGPAPLVS---AVPMATPAPAARAPAEEE 969
            +   KE+ +  E+A    +EEA  P    S   A  +   +P A+ PA+EE
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 101/470 (21%), Positives = 173/470 (36%), Gaps = 55/470 (11%)

Query: 487  SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
            SPE     S A    PE    P  +   K+P     PE    P    V E +K PA ++ 
Sbjct: 566  SPEKEEAKSPAEVKSPEKAKSPAKEE-AKSPAEAKSPEKAKSP----VKEEAKSPAEAKS 620

Query: 547  SPKAVASSPAATNSEVKMTS---------------------FAERKKQLVKAEAEA--GA 583
              K  A SPA   S  K  S                       E+ K  VKAEA++   A
Sbjct: 621  PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680

Query: 584  GSPTSTPA-PPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFA--KHRQRLGKSAFLQV 640
             SP    A  PE   S + E +   E+ +  ++ + +  E   +  K   +  + A   V
Sbjct: 681  KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740

Query: 641  QPREASGEAEAEAEEADSGPV--PGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGE 698
            +    S E     E+A +  V  P  + PA E    P  +      SP       E +  
Sbjct: 741  KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP-----VKEEVKS 795

Query: 699  YNRAVSKLSAALSSLQRDMQRLTDQQQRLL---APPEAPGSAPPPAAWVIPGPTTGPKAA 755
              +A S L     + ++++ +  + +  +     P E     PP  A     P T PK  
Sbjct: 796  PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT-PKTE 854

Query: 756  SPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSP 815
                +++  A ++       +  + P   +P E ++           D   +P   K +P
Sbjct: 855  EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE---EAEDKKKVPTPEKEAP 911

Query: 816  SQVPV----QTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSL 871
            ++V V    + +    +A++ P +  A  P   +      A P  +D  +      E+  
Sbjct: 912  AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPS--KPAEKKEAAPEKKDTKEEKAKKPEEKP 969

Query: 872  EEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRK 921
            + EA ++ + +       K+  KP+ E A+K +S  ++  +  E+A   K
Sbjct: 970  KTEAKAKEDDKT----LSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 64/294 (21%), Positives = 111/294 (37%), Gaps = 38/294 (12%)

Query: 868  EDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVE 927
            E  + EE + E E         K+E+  E+E  ++  +    ++ ++  A      ++  
Sbjct: 463  ETQVTEEVTEEEEKEA------KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA 516

Query: 928  KEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEV--GPRKGDFTRQEYERR 985
            K   +EEA   A+ ++P      S   + +P   A++PA+EE    P      ++E +  
Sbjct: 517  KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP-EKAKSPAKEEAKSPPEAKSPEKEEAKSP 575

Query: 986  AQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIY 1045
            A++K     +K   P    +  P      A  P          A+SPA            
Sbjct: 576  AEVK---SPEKAKSPAKEEAKSPA----EAKSPEKAKSPVKEEAKSPAE----------- 617

Query: 1046 SQSTLSLSTVANEAHNNLGVKRP-TSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASV 1104
                 + S V  EA +   VK P  +++P+     SP +     + + ++   A SP   
Sbjct: 618  -----AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672

Query: 1105 PEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEI---EKSKA 1155
             E   P   K P  K+       A S      K  E  K+ + EE    EK+K+
Sbjct: 673  -EAKSPEKAKSP-VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKS 724


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 129/608 (21%), Positives = 202/608 (33%), Gaps = 102/608 (16%)

Query: 431 SSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHS-----------------AEPRL 473
           +SD L  P+P P   P +P PE       E+      S                   PR 
Sbjct: 241 TSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRR 300

Query: 474 LPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCL 533
                +        P    +PS      P     P   R +++PV      + S      
Sbjct: 301 RHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSS 360

Query: 534 VGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPP 593
              +S+  +P +  PK  +S P  T       S   R+ +           SP +TP PP
Sbjct: 361 SSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHR----------PSPPATP-PP 409

Query: 594 EALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAE-AE 652
           +   S   + S R  + R  +     R      KH+   G        P     + E +E
Sbjct: 410 KTRHSPTPQQSNRTRKSR--VSVSPGRTSGKVTKHK---GTEKRESPSPAPKPRKVELSE 464

Query: 653 AEEADSGPVPGGE---------RPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAV 703
           +EE   G +   +         R   +   +  S   +    P    V +  +G   R  
Sbjct: 465 SEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHS 524

Query: 704 SKLSAALSSLQRDMQRL-TDQQQRLLAPP-----EAPGSAPPPAAWVIPGPTTGPKAASP 757
              SA+ S  +R  +     +++R  +PP      +P  APPP     P P    +  SP
Sbjct: 525 PSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSP 584

Query: 758 SPARRVPATRR---------SPGPGPSQSPRSP------------------KHTRPAELR 790
            P RR P+ RR         SP P P +   SP                   H+ P + R
Sbjct: 585 PPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQR 644

Query: 791 LAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGS 850
            +P+T+  +P     S  H +  SPS+   + RS       +P   P A       P  S
Sbjct: 645 SSPVTKRRSPSL---SSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRA-------PQTS 694

Query: 851 LADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQ 910
            + P        SP        +  S    P        +    PE +  +K AS   + 
Sbjct: 695 SSPPPVRRGASSSP-----QRRQSPSPSTRP------IRRVSRTPEPKKIKKAASPSPQS 743

Query: 911 QRRAEEARRRKQWQEVEKEQRREEAARLAQEEAP----GPAPLVSAVPMATPAPAARAPA 966
            RR   +R      E   ++     + + Q ++P     PA  V      TP+P+    +
Sbjct: 744 VRRVSSSRSVSGSPEPAAKKPPAPPSPV-QSQSPSTNWSPAVPVKKAKSPTPSPSPPRNS 802

Query: 967 EEEVGPRK 974
           ++E G +K
Sbjct: 803 DQEGGGKK 810



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 128/602 (21%), Positives = 212/602 (35%), Gaps = 94/602 (15%)

Query: 429  SVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSP 488
            S SS S  PP+  P RT + P           +  ++  SA P                 
Sbjct: 362  SSSSRSRSPPKKPPKRTSSPP----------RKTRRLSPSASPP-------------RRR 398

Query: 489  EGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSP 548
              PS P+   P      +   S+R  K+ V +    T  K +     E  + P+P+   P
Sbjct: 399  HRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAP-KP 457

Query: 549  KAVASSPAATNSEVKMTSF------AERKKQLVKAEAEAGAGSPTSTPAPPEA------- 595
            + V  S +  +   KM +        + ++Q  ++ +++G+ S +    P  +       
Sbjct: 458  RKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEV 517

Query: 596  ------LSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEA 649
                    S  +  S R  +K  +   ++RR  +     R+R    A     PR      
Sbjct: 518  GRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPA---PPPRRRRTPT 574

Query: 650  EAEAEEADS------GPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAV 703
                    S       P P    P  + +  P+  PK  T SP   P P           
Sbjct: 575  PPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPP--PPPKRRASPSPPPK 632

Query: 704  SKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRV 763
             ++S +    QR    +T ++   L+     GS+P  +      P    K  SPSP  R 
Sbjct: 633  RRVSHSPPPKQRS-SPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPN-KRHSPSPRPRA 690

Query: 764  PATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTR 823
            P T  SP P    +  SP+  +       P+ RV   P   +     +  SPS   V+  
Sbjct: 691  PQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTP---EPKKIKKAASPSPQSVRRV 747

Query: 824  SSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRV 883
            SS      +P  EPAA+                       PA       +  S+   P V
Sbjct: 748  SSSRSVSGSP--EPAAKK---------------------PPAPPSPVQSQSPSTNWSPAV 784

Query: 884  GLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEA 943
             +    K    P    +  R S     Q    + +++K+ ++ +K+++ ++  +  +E+A
Sbjct: 785  PV----KKAKSPTPSPSPPRNS----DQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKA 836

Query: 944  PGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAA 1003
               A   +  P A  A       EE V   +    ++E E  A+  L DDL+K LR +A 
Sbjct: 837  VAAAAAAAVTPAAIAAATTTLAQEEPVAAPE---PKKETESEAEDNL-DDLEKHLREKAL 892

Query: 1004 GS 1005
             S
Sbjct: 893  RS 894



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 60/292 (20%), Positives = 112/292 (38%), Gaps = 39/292 (13%)

Query: 855  AAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYK-DEDKPEDEMAQKRASLLERQQRR 913
            +A++   G P+   +  +EE       +  L    K DEDK + +  +K +S  +R++ R
Sbjct: 111  SAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSR 170

Query: 914  AEEARR------RKQWQEVEKEQRREEAA---RLAQEEAPGPAPLVSAVPMATPAPAARA 964
            +   R+      R++   V +E++R  +       +  +P PAP         P P+ + 
Sbjct: 171  SPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKV 230

Query: 965  PAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPR--AAGSGGPGRGGRRATRPRSGC 1022
              E  V         QE    + +  +   + +  P+  +          +  TRPRS  
Sbjct: 231  -KEPSV---------QEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRS 280

Query: 1023 CDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSP- 1081
               S  +R+ +R    +R  + +   + S S     +      +RP+ R  +P   M P 
Sbjct: 281  RSKSR-SRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPR----RRPSPRRRTPPRRMPPP 335

Query: 1082 -----SRLPGSRER------DWENGSNASSPASVPEYTGPRLYKEPSAKSNK 1122
                 SR P  R R         + S++SS +  P    P+    P  K+ +
Sbjct: 336  PRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRR 387



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 26/120 (21%), Positives = 46/120 (38%), Gaps = 7/120 (5%)

Query: 722 DQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSP 781
           ++++R  +P      +P P     P      ++ S SP  R  +  RSP P P +  ++P
Sbjct: 164 EKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKS--RSPSPAPEKKEKTP 221

Query: 782 KHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARP 841
           +   P+     P  +  T   D+  +P      P  +P     S     +   E+   RP
Sbjct: 222 ELPEPSVKVKEPSVQEATSTSDILKVP-----KPEPIPEPKEPSPEKNSKKEKEKEKTRP 276


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 169/790 (21%), Positives = 261/790 (33%), Gaps = 181/790 (22%)

Query: 330  GHAASPRGTEASPPQNNSGSSSPVF----TFRHPLLSSG---------GPQSPLRGSTGS 376
            GH  S  G  A PP   SG + P+     T + P+   G         GP  P    TGS
Sbjct: 320  GHEKSQPGP-AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGS 378

Query: 377  LKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLG 436
             K S      +AL        ++P     + +   G        +G P  L         
Sbjct: 379  EKPSSEQPGPKAL--------AQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSP 430

Query: 437  PPRPAPARTPTQPPPEPGDLPTIE------EALQIIHSAEPRLLPDGAADGSFYLHSPEG 490
               P P +TP Q P  PG +P  +       A Q   +  P  LP  A           G
Sbjct: 431  AKAPGPTKTPVQQPG-PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPP----QQPG 485

Query: 491  PSKPSLASPYLPEGTSKPLSDRP--TKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSP 548
            P+KP    P    G++KP S +P  TK P   P P  PS   P     ++KPP+   GS 
Sbjct: 486  PAKPPPQQP----GSAKPPSQQPGSTKPPPQQPGPAKPSPQQP----GSTKPPSQQPGSA 537

Query: 549  KAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA--------PPEALSSEM 600
            K  A  P+               +Q  K  ++ G+G P   P         P + L   +
Sbjct: 538  KPSAQQPSPAKPSA---------QQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI 588

Query: 601  ------SELSARLEEKRRAIEAQKRRIEAIFA------KHRQRLGKSAFLQVQPREASGE 648
                  +EL   + EK       + +             H   + +   L  Q + A G 
Sbjct: 589  CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALG- 647

Query: 649  AEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSA 708
                    D  PVP   +P  + +  P +   AV+ S    P P +              
Sbjct: 648  -------GDLAPVPSSPQP--KLKTAPVTTTSAVSKS---SPQPQQ-------------- 681

Query: 709  ALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRR 768
              +S ++D            AP +    AP P                P P  + P    
Sbjct: 682  --TSPKKD-----------AAPKQDLSKAPEP--------------KKPPPLVKQPTLHG 714

Query: 769  SPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILL 828
            SP     Q P +   ++PA        +  + P + D  P +    P Q  +   ++ L+
Sbjct: 715  SPSAKAKQPPEADSLSKPAP------PKEPSVPSEQDKAP-VADDKPKQPKMVKPTTDLV 767

Query: 829  AEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFF 888
            +  +   +P       +IP   +   A E     +P    DS +    S+  P  G    
Sbjct: 768  SSSSATTKP-------DIPSSKVQSQAEEKT---TPPLKTDSAK---PSQSFPPTG---- 810

Query: 889  YKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAP 948
              ++  P D  A  R +   +       +   K  ++V+  Q++EE  +   + +P P  
Sbjct: 811  --EKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPD- 867

Query: 949  LVSAVPMATPAPAARAPAEEEVGPRKGDFTR-QEYERRAQLKLMDDLDKVLRPRAAGSGG 1007
                +P  +P P    P   +  P      + QE  RR  L L                 
Sbjct: 868  -AKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNL----------------- 909

Query: 1008 PGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEA-HNNLGVK 1066
                G     P+S         +    G L    + I+SQ++  +ST      H+  G  
Sbjct: 910  ----GSITDAPKS----QPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961

Query: 1067 RPTSRAPSPS 1076
             P  +AP+PS
Sbjct: 962  APMKQAPAPS 971



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 110/517 (21%), Positives = 175/517 (33%), Gaps = 94/517 (18%)

Query: 319 PDFVQVKDLPDGHAASPRGTEASP---PQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTG 375
           P   + ++L   H     G    P    Q     S    TFR      G  +SP   ST 
Sbjct: 79  PSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPG--RSP---STI 133

Query: 376 SLKSSPSMS-----HMEALGKAWNRQLSR--PLSQAVSFSTPFGLDSDVDVVMGDPVLLR 428
           SLK S S +     H  ++   +  +++    +S  V+   PF L SD +    +    +
Sbjct: 134 SLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQ 193

Query: 429 SVSSDSLGPP----RPAPARTPTQPPPE---PGDLPTIEEAL-QIIHSAEPRLLPDGAAD 480
            V     G P    +P   + P +P P+   PG  P  ++   + I S +P  +      
Sbjct: 194 KVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPG 253

Query: 481 GSFYLHSP--------------EGPSKPSLASPYLPEGTS-KPLSDRPTKAPVYMPHPET 525
               +  P                 S+P      +  G S KP    P+K P+  P P  
Sbjct: 254 TGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGK 313

Query: 526 P---------SKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLV- 575
           P         S+P P      +KPPA   G  K +A  P      V+     +   Q + 
Sbjct: 314 PPAQQPGHEKSQPGP------AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367

Query: 576 ---KAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRL 632
                  + G+  P+S    P+AL+          ++   A    ++          + L
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQ------VGTPKPL 421

Query: 633 GKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVP 692
            +   LQ  P +A G  +   ++   G +P  +   G+   + T   K  +  P     P
Sbjct: 422 AQQPGLQ-SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPP 480

Query: 693 HEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPP-EAPGSAPPPAAWVIPGPTTG 751
            +  G                     +   QQ     PP + PGS  PP     PGP   
Sbjct: 481 PQQPGP-------------------AKPPPQQPGSAKPPSQQPGSTKPPPQQ--PGP--- 516

Query: 752 PKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAE 788
              A PSP +  P + + P   P  +  S +   PA+
Sbjct: 517 ---AKPSPQQ--PGSTKPPSQQPGSAKPSAQQPSPAK 548



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 89/419 (21%), Positives = 140/419 (33%), Gaps = 71/419 (16%)

Query: 424  PVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSF 483
            PV   S  S S   P+    +    P  +    P  ++         P L+      GS 
Sbjct: 665  PVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKP--------PPLVKQPTLHGSP 716

Query: 484  YLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPS--KPSPCLVGEASKPP 541
               + + P   SL+ P  P+  S P      KAPV    P+ P   KP+  LV  +S   
Sbjct: 717  SAKAKQPPEADSLSKPAPPKEPSVP--SEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774

Query: 542  APSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMS 601
             P   S K  + +   T   +K  S   +  Q      E  +   +     P + S  +S
Sbjct: 775  KPDIPSSKVQSQAEEKTTPPLKTDS--AKPSQSFPPTGEKVSPFDSKAIPRPASDSKIIS 832

Query: 602  ELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSG-P 660
                  E K +      ++++ +  K      K A  ++ P+        +A+    G P
Sbjct: 833  HPGPSSESKGQ------KQVDPVQKKEEP---KKAQTKMSPKP-------DAKPMPKGSP 876

Query: 661  VPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
             P G RP   GQ  PT         P   P P E    ++  +  ++             
Sbjct: 877  TPPGPRPTA-GQTVPT---------PQQSPKPQEQSRRFSLNLGSIT------------- 913

Query: 721  TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRS 780
                       +AP S P      + G   G  A+  S A  + +T   PGP     P +
Sbjct: 914  -----------DAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGA 962

Query: 781  PKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAA 839
            P    PA  +  P ++   PP      P         +PV+  +    AE+  P+   A
Sbjct: 963  PMKQAPAPSQ-PPTSQ--GPPKSTGQAP---PAPAKSIPVKKETKAPAAEKLEPKAEQA 1015



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 112/573 (19%), Positives = 206/573 (35%), Gaps = 67/573 (11%)

Query: 442  PARTPTQPPPEPGDLP-TIEEALQIIHSAEPRLLPDGAA-----DGSFYLHSPEGPSKPS 495
            P+ TP   P E      TI+E  Q   +A+P  +  G       D      S + P  P 
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358

Query: 496  LASP--YLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVAS 553
              S   Y  +G S  L + P+  P          K         S+  +PS  S  A   
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKD-----SFSQESSPSSPSDLAKLE 1413

Query: 554  SPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTS---TPAPPEALSSEMSELSARLEEK 610
            S   +  E + ++ A+ K +      E     P     T +  E L   +SE   +  ++
Sbjct: 1414 STVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473

Query: 611  RRAIEAQKRRIEAIFAKHRQRLGKSAFLQ-VQPREASGEAEAEAEEADSGPVPGGERPA- 668
             R  +  K+  +      +    KS F+  +  R    ++  E+ E+++ PVP  +R   
Sbjct: 1474 ERK-DTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTS 1532

Query: 669  ---------------GEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSL 713
                           G G+ E   R + +  S D      E        + ++S++  S 
Sbjct: 1533 VGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQ 1592

Query: 714  QRDMQR----LTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRS 769
            +++  +    +T  + R L    +  S    A           +A   SP  +   T+  
Sbjct: 1593 KKEETKGKGKITAGKHRRLTRKSST-SIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQ 1651

Query: 770  P--------GPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPV- 820
                     G G  +      ++  A+   A  ++  T  +  D  P L   S +  P  
Sbjct: 1652 ESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLY-FDEEPELEMESLTDSPED 1710

Query: 821  ----QTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEAS 876
                +  SS+  +  TP   P +   L             +++ D SP+  +   +++  
Sbjct: 1711 RSRGEGSSSLHASSFTPGTSPTSVSSL-------------DEDSDSSPSHKKGESKQQRK 1757

Query: 877  SEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAA 936
            +   P   L    +D  + E+E+ ++   L E++++R  E ++RK   +  K+ + E  A
Sbjct: 1758 ARHRPHGPLLPTIEDSSE-EEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRA 1816

Query: 937  RLAQEEAPGPAPLVSAVPMATPAPAARAPAEEE 969
            +  +E    P   +S +  A+P    R  AE E
Sbjct: 1817 QRRRERPKTPPSNLSPIEDASPTEELRQAAEME 1849



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 49/185 (26%), Positives = 68/185 (36%), Gaps = 32/185 (17%)

Query: 430  VSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPE 489
            +S+    PP P P   P  PPP P  LP          S +P +LP         + SP 
Sbjct: 2401 ISAQPPPPPPPPPPPPPPPPPPPPPPLPPPT-------SPKPTILP----KKKLTVASPV 2449

Query: 490  GPSKP------SLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVG-------E 536
              + P      +L +  +      P++   T AP     P  P KPS    G       E
Sbjct: 2450 TTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP-----PPVPPKPSSIPSGLVFTHRPE 2504

Query: 537  ASKPP-APSEGSPKAVASSPAATNSEVKMTSFAERKKQLVK--AEAEAGAGSPTSTPAPP 593
             SKPP AP    P+   ++   T+   K T  +      +     A+    SPTS  +P 
Sbjct: 2505 PSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPH 2564

Query: 594  EALSS 598
               SS
Sbjct: 2565 SNKSS 2569


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 169/790 (21%), Positives = 261/790 (33%), Gaps = 181/790 (22%)

Query: 330  GHAASPRGTEASPPQNNSGSSSPVF----TFRHPLLSSG---------GPQSPLRGSTGS 376
            GH  S  G  A PP   SG + P+     T + P+   G         GP  P    TGS
Sbjct: 320  GHEKSQPGP-AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGS 378

Query: 377  LKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLG 436
             K S      +AL        ++P     + +   G        +G P  L         
Sbjct: 379  EKPSSEQPGPKAL--------AQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSP 430

Query: 437  PPRPAPARTPTQPPPEPGDLPTIE------EALQIIHSAEPRLLPDGAADGSFYLHSPEG 490
               P P +TP Q P  PG +P  +       A Q   +  P  LP  A           G
Sbjct: 431  AKAPGPTKTPVQQPG-PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPP----QQPG 485

Query: 491  PSKPSLASPYLPEGTSKPLSDRP--TKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSP 548
            P+KP    P    G++KP S +P  TK P   P P  PS   P     ++KPP+   GS 
Sbjct: 486  PAKPPPQQP----GSAKPPSQQPGSTKPPPQQPGPAKPSPQQP----GSTKPPSQQPGSA 537

Query: 549  KAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA--------PPEALSSEM 600
            K  A  P+               +Q  K  ++ G+G P   P         P + L   +
Sbjct: 538  KPSAQQPSPAKPSA---------QQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI 588

Query: 601  ------SELSARLEEKRRAIEAQKRRIEAIFA------KHRQRLGKSAFLQVQPREASGE 648
                  +EL   + EK       + +             H   + +   L  Q + A G 
Sbjct: 589  CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALG- 647

Query: 649  AEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSA 708
                    D  PVP   +P  + +  P +   AV+ S    P P +              
Sbjct: 648  -------GDLAPVPSSPQP--KLKTAPVTTTSAVSKS---SPQPQQ-------------- 681

Query: 709  ALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRR 768
              +S ++D            AP +    AP P                P P  + P    
Sbjct: 682  --TSPKKD-----------AAPKQDLSKAPEP--------------KKPPPLVKQPTLHG 714

Query: 769  SPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILL 828
            SP     Q P +   ++PA        +  + P + D  P +    P Q  +   ++ L+
Sbjct: 715  SPSAKAKQPPEADSLSKPAP------PKEPSVPSEQDKAP-VADDKPKQPKMVKPTTDLV 767

Query: 829  AEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFF 888
            +  +   +P       +IP   +   A E     +P    DS +    S+  P  G    
Sbjct: 768  SSSSATTKP-------DIPSSKVQSQAEEKT---TPPLKTDSAK---PSQSFPPTG---- 810

Query: 889  YKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAP 948
              ++  P D  A  R +   +       +   K  ++V+  Q++EE  +   + +P P  
Sbjct: 811  --EKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPD- 867

Query: 949  LVSAVPMATPAPAARAPAEEEVGPRKGDFTR-QEYERRAQLKLMDDLDKVLRPRAAGSGG 1007
                +P  +P P    P   +  P      + QE  RR  L L                 
Sbjct: 868  -AKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNL----------------- 909

Query: 1008 PGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEA-HNNLGVK 1066
                G     P+S         +    G L    + I+SQ++  +ST      H+  G  
Sbjct: 910  ----GSITDAPKS----QPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961

Query: 1067 RPTSRAPSPS 1076
             P  +AP+PS
Sbjct: 962  APMKQAPAPS 971



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 110/517 (21%), Positives = 175/517 (33%), Gaps = 94/517 (18%)

Query: 319 PDFVQVKDLPDGHAASPRGTEASP---PQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTG 375
           P   + ++L   H     G    P    Q     S    TFR      G  +SP   ST 
Sbjct: 79  PSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPG--RSP---STI 133

Query: 376 SLKSSPSMS-----HMEALGKAWNRQLSR--PLSQAVSFSTPFGLDSDVDVVMGDPVLLR 428
           SLK S S +     H  ++   +  +++    +S  V+   PF L SD +    +    +
Sbjct: 134 SLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQ 193

Query: 429 SVSSDSLGPP----RPAPARTPTQPPPE---PGDLPTIEEAL-QIIHSAEPRLLPDGAAD 480
            V     G P    +P   + P +P P+   PG  P  ++   + I S +P  +      
Sbjct: 194 KVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPG 253

Query: 481 GSFYLHSP--------------EGPSKPSLASPYLPEGTS-KPLSDRPTKAPVYMPHPET 525
               +  P                 S+P      +  G S KP    P+K P+  P P  
Sbjct: 254 TGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGK 313

Query: 526 P---------SKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLV- 575
           P         S+P P      +KPPA   G  K +A  P      V+     +   Q + 
Sbjct: 314 PPAQQPGHEKSQPGP------AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367

Query: 576 ---KAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRL 632
                  + G+  P+S    P+AL+          ++   A    ++          + L
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQ------VGTPKPL 421

Query: 633 GKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVP 692
            +   LQ  P +A G  +   ++   G +P  +   G+   + T   K  +  P     P
Sbjct: 422 AQQPGLQ-SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPP 480

Query: 693 HEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPP-EAPGSAPPPAAWVIPGPTTG 751
            +  G                     +   QQ     PP + PGS  PP     PGP   
Sbjct: 481 PQQPGP-------------------AKPPPQQPGSAKPPSQQPGSTKPPPQQ--PGP--- 516

Query: 752 PKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAE 788
              A PSP +  P + + P   P  +  S +   PA+
Sbjct: 517 ---AKPSPQQ--PGSTKPPSQQPGSAKPSAQQPSPAK 548



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 89/419 (21%), Positives = 140/419 (33%), Gaps = 71/419 (16%)

Query: 424  PVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSF 483
            PV   S  S S   P+    +    P  +    P  ++         P L+      GS 
Sbjct: 665  PVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKP--------PPLVKQPTLHGSP 716

Query: 484  YLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPS--KPSPCLVGEASKPP 541
               + + P   SL+ P  P+  S P      KAPV    P+ P   KP+  LV  +S   
Sbjct: 717  SAKAKQPPEADSLSKPAPPKEPSVP--SEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774

Query: 542  APSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMS 601
             P   S K  + +   T   +K  S   +  Q      E  +   +     P + S  +S
Sbjct: 775  KPDIPSSKVQSQAEEKTTPPLKTDS--AKPSQSFPPTGEKVSPFDSKAIPRPASDSKIIS 832

Query: 602  ELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSG-P 660
                  E K +      ++++ +  K      K A  ++ P+        +A+    G P
Sbjct: 833  HPGPSSESKGQ------KQVDPVQKKEEP---KKAQTKMSPKP-------DAKPMPKGSP 876

Query: 661  VPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
             P G RP   GQ  PT         P   P P E    ++  +  ++             
Sbjct: 877  TPPGPRPTA-GQTVPT---------PQQSPKPQEQSRRFSLNLGSIT------------- 913

Query: 721  TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRS 780
                       +AP S P      + G   G  A+  S A  + +T   PGP     P +
Sbjct: 914  -----------DAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGA 962

Query: 781  PKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAA 839
            P    PA  +  P ++   PP      P         +PV+  +    AE+  P+   A
Sbjct: 963  PMKQAPAPSQ-PPTSQ--GPPKSTGQAP---PAPAKSIPVKKETKAPAAEKLEPKAEQA 1015



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 112/573 (19%), Positives = 206/573 (35%), Gaps = 67/573 (11%)

Query: 442  PARTPTQPPPEPGDLP-TIEEALQIIHSAEPRLLPDGAA-----DGSFYLHSPEGPSKPS 495
            P+ TP   P E      TI+E  Q   +A+P  +  G       D      S + P  P 
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358

Query: 496  LASP--YLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVAS 553
              S   Y  +G S  L + P+  P          K         S+  +PS  S  A   
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKD-----SFSQESSPSSPSDLAKLE 1413

Query: 554  SPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTS---TPAPPEALSSEMSELSARLEEK 610
            S   +  E + ++ A+ K +      E     P     T +  E L   +SE   +  ++
Sbjct: 1414 STVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473

Query: 611  RRAIEAQKRRIEAIFAKHRQRLGKSAFLQ-VQPREASGEAEAEAEEADSGPVPGGERPA- 668
             R  +  K+  +      +    KS F+  +  R    ++  E+ E+++ PVP  +R   
Sbjct: 1474 ERK-DTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTS 1532

Query: 669  ---------------GEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSL 713
                           G G+ E   R + +  S D      E        + ++S++  S 
Sbjct: 1533 VGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQ 1592

Query: 714  QRDMQR----LTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRS 769
            +++  +    +T  + R L    +  S    A           +A   SP  +   T+  
Sbjct: 1593 KKEETKGKGKITAGKHRRLTRKSST-SIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQ 1651

Query: 770  P--------GPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPV- 820
                     G G  +      ++  A+   A  ++  T  +  D  P L   S +  P  
Sbjct: 1652 ESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLY-FDEEPELEMESLTDSPED 1710

Query: 821  ----QTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEAS 876
                +  SS+  +  TP   P +   L             +++ D SP+  +   +++  
Sbjct: 1711 RSRGEGSSSLHASSFTPGTSPTSVSSL-------------DEDSDSSPSHKKGESKQQRK 1757

Query: 877  SEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAA 936
            +   P   L    +D  + E+E+ ++   L E++++R  E ++RK   +  K+ + E  A
Sbjct: 1758 ARHRPHGPLLPTIEDSSE-EEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRA 1816

Query: 937  RLAQEEAPGPAPLVSAVPMATPAPAARAPAEEE 969
            +  +E    P   +S +  A+P    R  AE E
Sbjct: 1817 QRRRERPKTPPSNLSPIEDASPTEELRQAAEME 1849



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 49/185 (26%), Positives = 68/185 (36%), Gaps = 32/185 (17%)

Query: 430  VSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPE 489
            +S+    PP P P   P  PPP P  LP          S +P +LP         + SP 
Sbjct: 2401 ISAQPPPPPPPPPPPPPPPPPPPPPPLPPPT-------SPKPTILP----KKKLTVASPV 2449

Query: 490  GPSKP------SLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVG-------E 536
              + P      +L +  +      P++   T AP     P  P KPS    G       E
Sbjct: 2450 TTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP-----PPVPPKPSSIPSGLVFTHRPE 2504

Query: 537  ASKPP-APSEGSPKAVASSPAATNSEVKMTSFAERKKQLVK--AEAEAGAGSPTSTPAPP 593
             SKPP AP    P+   ++   T+   K T  +      +     A+    SPTS  +P 
Sbjct: 2505 PSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPH 2564

Query: 594  EALSS 598
               SS
Sbjct: 2565 SNKSS 2569


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/273 (27%), Positives = 101/273 (36%), Gaps = 41/273 (15%)

Query: 642 PREASGEAEA--------EAEEADSGPVPGG------ERPAGEGQGEPTSRPKAVTF--S 685
           P  A+GEA          +A  A S P+P G      ++P      +  + P+A T   S
Sbjct: 608 PAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPS 667

Query: 686 PDLGPVPHE-GLGEYNRAVSKLSAALSSLQ------RDMQRLTDQQQRLLAPPEAPGSAP 738
           P L   P +  LG+   A         SLQ      R  Q L+ +   L  P     SAP
Sbjct: 668 PGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAP 727

Query: 739 PPAAWVIP------GPTTGPKA----ASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAE 788
           PPA    P      G   GP+A    ASP+PA ++PA     GPGPS SP  P      +
Sbjct: 728 PPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGD 787

Query: 789 LRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPL 848
               P      PP    S P      PS+ P        L    PP+ P   PG+  I  
Sbjct: 788 SPHLPSPHPTRPPSRPPSRPQSVSRPPSEPP--------LHPCPPPQAPPTLPGIFVIQN 839

Query: 849 GSLADPAAEDEGDGSPAGAEDSLEEEASSEGEP 881
                P A +    +P   +  L  ++     P
Sbjct: 840 QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGP 872



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 112/469 (23%), Positives = 168/469 (35%), Gaps = 62/469 (13%)

Query: 424 PVLLRSVSSDSLGPPRPA-PARTP-----TQPPPEPGDLPTIEEALQIIHSAEPRLLPDG 477
           PV L + S  +   P PA PA T      T PP     L T +  +Q    A P      
Sbjct: 558 PVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLVQ---PATPAAATGE 614

Query: 478 AADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYM---PHPETPSKPSPCLV 534
           AA       +P+ P  P++++P LP G  +P + +P +AP      P   T  +PSP   
Sbjct: 615 AAPVLTVQPAPQAP--PAVSTP-LPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSP--- 668

Query: 535 GEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEA-EAGAGSPTSTPAPP 593
           G AS P     G P +   +   T   ++M    ER +Q + AE       +     APP
Sbjct: 669 GLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPP 728

Query: 594 EALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEA 653
            A         A    K   +  Q    +A  A   Q +  +A L+     +S     +A
Sbjct: 729 PA----QDPAPATPVAKGAGLGPQAPDSQASPAPAPQ-IPAAAPLKGPGPSSSPSLPHQA 783

Query: 654 EEADSG--PVPGGERPAGEGQGEPTSRPKAVT---FSPDLGPVPHEGLGEYNRAVSKLSA 708
              DS   P P   RP       P SRP++V+     P L P P          +  +  
Sbjct: 784 PLGDSPHLPSPHPTRPPSR----PPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQN 839

Query: 709 ALSSLQRDMQRLTDQQQRLLAPPEAP--GSAPPPAAWVIPGPTTGPKAASPSPARRVPAT 766
            L          ++       PP+ P    + PP   + P P   P + S + A     +
Sbjct: 840 QLGV----PPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETS 895

Query: 767 RRSPGPGPSQ-----SPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQ 821
            R P P PS       P    H  P            TPP  +  +P     +P   P +
Sbjct: 896 SRLPAPTPSDFQLQFPPSQGPHKSP------------TPPPTLHLVP--EPAAPPPPPPR 941

Query: 822 TRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDS 870
           T   +       P+  A      ++P G +     +++  G+PA  + S
Sbjct: 942 TFQMVTTPFPALPQPKALLERFHQVPSGII----LQNKAGGAPAAPQTS 986



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 134/704 (19%), Positives = 216/704 (30%), Gaps = 93/704 (13%)

Query: 342 PPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPL 401
           PPQ+    +  V  F  P+        P+ G  G    SP  +    LG A  + + +P+
Sbjct: 183 PPQDVVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPIQVVGQPV 242

Query: 402 SQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPG------- 454
                      L++    ++   V +    + + GP  P    +    P   G       
Sbjct: 243 ---------MALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNL 293

Query: 455 --DLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASP-YLPEGTSKPLSD 511
              + T      +   A     P G   G     +P   S P + +P  +   T  P+  
Sbjct: 294 SAAVATTLNGNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQP 353

Query: 512 RPT-----KAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTS 566
           +P      K     P P  P+  +  + GE    P   +        +       V ++ 
Sbjct: 354 KPAGVLPPKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSG 413

Query: 567 FAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFA 626
           F     Q    +      +  + P PP ALS  MS            +    +    +  
Sbjct: 414 FPAPALQANVFKQPPATTTGAAPPQPPGALSKPMS------------VHLLNQGSSIVIP 461

Query: 627 KHRQRLGKSAFLQVQPREASGEAEAEAEEAD-SGPVPGGERPAGEGQ--GEPTSRPKAVT 683
                 G++ FL           +  A  A+  G +     P   GQ    P    + + 
Sbjct: 462 AQHMLPGQNQFLLPGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLA 521

Query: 684 FSPDLGPV--PHEG-------------LGEYNRAVSKLSAALSSLQRDMQ------RLTD 722
               LGPV  PH G             +G+       +S A  SL    Q        T 
Sbjct: 522 GPLSLGPVLAPHSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATT 581

Query: 723 QQQRLLAPPEAPGSAPPPAAWVIPG-PTTGPKAASP----SPARRVPATRRSPGPGPSQS 777
             Q +  PP A      P   V P  P      A+P     PA + P    +P P   Q 
Sbjct: 582 VLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQ 641

Query: 778 PRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP---P 834
           P++ +  +    + A   +  TP           K    Q P  T ++IL  +      P
Sbjct: 642 PQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLP 701

Query: 835 EEPAARPGLIEIPLGSL-------ADPAAEDEGDGSPAGAEDSL-----EEEASSEGEPR 882
           +E + +P   E P  S+       A P A+D    +P      L     + +AS    P+
Sbjct: 702 QERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQ 761

Query: 883 VGLGFFYKDEDKPEDEMAQKRASL-----LERQQRRAEEARRRKQWQEVEKEQRREEAAR 937
           +      K            +A L     L         +R   + Q V +         
Sbjct: 762 IPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHP 821

Query: 938 LAQEEAPGPAPLVSAV--------PMATPAPAARAPAEEEVGPR 973
               +AP   P +  +        P + PAP A  P +  + P+
Sbjct: 822 CPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQ 865



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 69/298 (23%), Positives = 98/298 (32%), Gaps = 56/298 (18%)

Query: 334 SPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGST---GSLKSSPSMSHMEALG 390
           +P    A+PPQ  +   SP        +  G P S    +     SL+        +   
Sbjct: 650 APTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPL 709

Query: 391 KAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPP 450
            A    LS P S  VS   P   D      +     L   + DS   P PAP      P 
Sbjct: 710 SAEGPHLSVPASVIVSAPPP-AQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPL 768

Query: 451 PEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLS 510
             PG             S+ P L        S +L SP  P++P    P  P+  S+P S
Sbjct: 769 KGPGP------------SSSPSLPHQAPLGDSPHLPSPH-PTRPPSRPPSRPQSVSRPPS 815

Query: 511 DRP------------------------TKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
           + P                           P   P P  P  P P L  ++  P  P   
Sbjct: 816 EPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPP 875

Query: 547 SP--------KAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEAL 596
           +P         AVASS + T+S +   + ++ + Q   ++       P  +P PP  L
Sbjct: 876 APHLPPSSTSSAVASS-SETSSRLPAPTPSDFQLQFPPSQ------GPHKSPTPPPTL 926



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 77/319 (24%), Positives = 110/319 (34%), Gaps = 57/319 (17%)

Query: 323  QVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPS 382
            Q  D     A +P+   A+P +    SSSP    + PL  S  P  P    T      PS
Sbjct: 748  QAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDS--PHLPSPHPTRPPSRPPS 805

Query: 383  MSHMEALGKAWNRQLSRPLSQAVSFSTP-----------FGLDSDVDVVMGDPVLLRSVS 431
                        + +SRP S+      P           F + +     +G P    + +
Sbjct: 806  RP----------QSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQ----LGVPPPASNPA 851

Query: 432  SDSLGPPRPAPARTPTQPP----PEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHS 487
              + GPP+P P R  +QPP    P    LP    +  +  S+E            F L  
Sbjct: 852  PTAPGPPQP-PLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQF 910

Query: 488  P--EGPSKPSLASPYL---PEGTSKPLSDRPTKAPVYMPHPETPSK----------PSPC 532
            P  +GP K     P L   PE  + P     T   V  P P  P            PS  
Sbjct: 911  PPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGI 970

Query: 533  LVGE--ASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGA-----GS 585
            ++       P AP   +     +SPAA+   V ++  A        + A A A     G 
Sbjct: 971  ILQNKAGGAPAAPQTSTSLGPLTSPAAS---VLVSGQAPSGTPTAPSHAPAPAPMAATGL 1027

Query: 586  PTSTPAPPEALSSEMSELS 604
            P   PA  +A +S +  L+
Sbjct: 1028 PPLLPAENKAFASNLPTLN 1046



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 46/206 (22%), Positives = 72/206 (34%), Gaps = 21/206 (10%)

Query: 329  DGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSP----LRGSTGSLKSSPSMS 384
            +GH     G  +S     S    P    +  +   G   SP     R S+    SS S S
Sbjct: 1217 EGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSSSSSS 1276

Query: 385  HMEALGKAWNRQL---SRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPA 441
               +L    +  +   +RP  +     +  GL   +    G   ++ + + D +  P P 
Sbjct: 1277 AASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPP 1336

Query: 442  P-----ARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGP----S 492
            P     A  P +PPP P     +   +     A P   P G A      H P  P     
Sbjct: 1337 PATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAP-----HCPRLPLRKTY 1391

Query: 493  KPSLASPYLPEGTSKPLSDRPTKAPV 518
            + ++  P  PEGT    +   + AP+
Sbjct: 1392 RENVGGPGAPEGTPAGRARGGSPAPL 1417



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 1/83 (1%)

Query: 441  APARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPS-LASP 499
            AP+ TPT P   P   P     L  +  AE +         +    +  GP KPS L   
Sbjct: 1005 APSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYE 1064

Query: 500  YLPEGTSKPLSDRPTKAPVYMPH 522
                G  KP + +P+K   ++ H
Sbjct: 1065 SKLSGLKKPPTLQPSKEACFLEH 1087


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 80/322 (24%), Positives = 115/322 (35%), Gaps = 52/322 (16%)

Query: 661  VPGGERPAGEGQGEPTSRPKAV---TFSPDL---GPVPHEGLGEYNRA-VSKLSAALSSL 713
            +PG E        +P   P      T  PD    G VP      Y++   S +  +L S 
Sbjct: 724  LPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESD 783

Query: 714  QRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPG 773
              D   +  +    L PP   G+ PPP A     PT  P A+ P PA+  P    +  PG
Sbjct: 784  SDDSVVIVPEGLPPLPPPPPSGATPPPIA-----PTGPPTASPPVPAKEEPEELPA-APG 837

Query: 774  PSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP 833
            P   P  P    P  + L P                     P  VP          E TP
Sbjct: 838  PLPPPPPPPPPVPGPVTLPP---------------------PQLVP----------EGTP 866

Query: 834  PE--EPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKD 891
                 PA    L  I + S  +   E+E +      E+  EE+   E E        Y +
Sbjct: 867  GGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEE----YFE 922

Query: 892  EDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRRE--EAARLAQEEAPGPAPL 949
            E++ E+E  ++     E +    EE    ++ +E+E+ +  E   A    +E AP P  L
Sbjct: 923  EEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTL 982

Query: 950  VSAVPMATPAPAARAPAEEEVG 971
              A+P     P  +   E E G
Sbjct: 983  PPALPPPESPPKVQPEPEPEPG 1004



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 100/433 (23%), Positives = 149/433 (34%), Gaps = 66/433 (15%)

Query: 356  FRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLS-QAVSFSTPFGLD 414
            FR P     GP  P  GS  S    PS   M + G   + +   P +   +  S P GL 
Sbjct: 660  FRAPPFHPPGPM-PSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVP-GLV 717

Query: 415  SDVDVVMGDPVLLRSVSSDSLGPPRPAPARTP--TQPPPEP--GDLPTI-------EEAL 463
            S    ++  P   R+ S++    P  AP+ TP  T PP E   G +P         EEA 
Sbjct: 718  SVPPRLLPGPENHRAGSNED---PILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEAS 774

Query: 464  QIIHSAEPR------LLPDGAAD-----GSFYLHSPEGPSKPSLASPYLPEGTSKPLSDR 512
             +  S E        ++P+G         S     P  P+ P  ASP +P   +K   + 
Sbjct: 775  DVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVP---AKEEPEE 831

Query: 513  PTKAPVYMPHPETPSKPSPCLVGEASKPP-------APSEGSPKAVASSPAATNSEVKMT 565
               AP  +P P  P  P P   G  + PP        P  G P A+       N    + 
Sbjct: 832  LPAAPGPLPPPPPPPPPVP---GPVTLPPPQLVPEGTPGGGGPPALEEDLTVIN----IN 884

Query: 566  SFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIF 625
            S  E +++  + E E             E    E  +     E++    E ++   E   
Sbjct: 885  SSDEEEEEEEEEEEEE------------EEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFE 932

Query: 626  AKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVT-- 683
             +  +  G+   L+ +  E   E E E EE +            EG   P + P A+   
Sbjct: 933  EEFEEEEGE---LEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPP 989

Query: 684  -FSPDLGPVPHEGLG---EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPP 739
               P + P P    G   E     ++      +           Q  +    E+P + PP
Sbjct: 990  ESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPP 1049

Query: 740  PAAWVIPGPTTGP 752
            P   V   P+  P
Sbjct: 1050 PQELVEEEPSAPP 1062



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 43/163 (26%), Positives = 65/163 (39%), Gaps = 36/163 (22%)

Query: 437  PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
            PP  +P +   +P PEPG L  +E         EP    +  AD           + P+L
Sbjct: 987  PPPESPPKVQPEPEPEPGLLLEVE---------EPGTEEERGAD-----------TAPTL 1026

Query: 497  ASPYLPEGTSKPLSDRPTKAPVYMPHP-----ETPSKPSPCLVGEASKPPAPSEGSPKAV 551
            A   LP   S+   +R  ++P   P P     E PS P P L+ E ++     +GS K  
Sbjct: 1027 APEALP---SQGEVEREGESPAAGPPPQELVEEEPSAP-PTLLEEETE-----DGSDK-- 1075

Query: 552  ASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPE 594
               P  T +E +M +  E +    K + +  A        PP+
Sbjct: 1076 VQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPD 1118



 Score = 33.9 bits (76), Expect = 1.00
 Identities = 30/105 (28%), Positives = 40/105 (38%), Gaps = 22/105 (20%)

Query: 513  PTKAPVYMPHPETPSK------PSPCLVGEASKPPAPSE-GSPKAVASSPAATNSEVKMT 565
            P   P  +P PE+P K      P P L+ E  +P    E G+  A   +P A  S+    
Sbjct: 979  PPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQ---- 1034

Query: 566  SFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEK 610
                        E E    SP + P P E +  E S     LEE+
Sbjct: 1035 -----------GEVEREGESPAAGPPPQELVEEEPSAPPTLLEEE 1068


>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
          Length = 962

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 160/713 (22%), Positives = 235/713 (32%), Gaps = 173/713 (24%)

Query: 339 EASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEAL-------GK 391
           E SP +  S     V   R P     GP +PL    G+      + H  AL       G 
Sbjct: 271 EVSPEERPSSGQQDVAPDRGP---EPGPPAPLPPPGGARARRARLQHSSALTASVEEGGV 327

Query: 392 AWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAP--ARTPTQP 449
                 SRP       +TP   + +       P L     S   GPP P P   +   + 
Sbjct: 328 PGEDPSSRP-------ATPELAEPE-----SAPTLRVEPPSPPEGPPNPGPDGGKQDGEA 375

Query: 450 PPEPGDLPTIEEALQIIHSAE------PRLLPDG-----AADGSFYLHSPEGPSKPSLAS 498
           PP     P  ++A +++ + E      P  +P+G       D +    +P     P  + 
Sbjct: 376 PPAGPCAPATDKAEEVVCAPEDVASPFPTAIPEGDTTPPETDPAATSEAPSARDGPERSV 435

Query: 499 PYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSP---------CLVGEASKPPAPSEGSPK 549
           P   E T   L D     P   P PE  ++  P          +  E S  PAPS  +PK
Sbjct: 436 PKEAEPTPPVLPDEEKGPPGPAPEPEREAETEPERGAGTEPERIGTEPSTAPAPSPPAPK 495

Query: 550 AVASSPAATNSEVKMTSFAERKKQLVKAEA---EAGAGSPTSTPAPPEALSSEMSELSAR 606
           +      A  SE    S       L  AE+   E G GS  +  A PE   +E +E    
Sbjct: 496 SCLKHRPAAASEGPAAS-----PPLAAAESPPVEPGPGSLDAEAAAPERPKAERAEAPPA 550

Query: 607 LEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGER 666
             E+     A +R+ E   A+ R                 G  +       + P PG  R
Sbjct: 551 GAERA----APERKAERGGAELR-----------------GAKKFSVSSCRARPRPGVSR 589

Query: 667 PAGEGQGE-PTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQ 725
           P     G  P +R          GPV             +  AAL  LQ           
Sbjct: 590 PLERASGRLPLARS---------GPV------------WRSEAALDDLQ----------- 617

Query: 726 RLLAPPEAPGSAPPPAAWVIPGPT-TGPKAASPSPARR-------VPATRRSPGPGPSQS 777
                PE   + P P      GP  +G +AASP+  R+        P TR         +
Sbjct: 618 ---GLPEPQHAKPGPRKLAERGPQDSGDRAASPAGPRKSPQEAAAAPGTREPCPAAQEPA 674

Query: 778 PRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEE------ 831
           P   ++  P +LR   L+           +  ++++S ++V ++   ++L  EE      
Sbjct: 675 PSEDRNPFPVKLRSTSLSLKYRDGAS-QEVKGVKRYS-AEVRLERSLTVLPKEEKCPLGT 732

Query: 832 ------------------TPPEEPAARPGLIEIPLGSL----ADPAAEDEGDGSPAGAED 869
                              PPE  +++P L   PL         PA  D G G       
Sbjct: 733 APALRGTRAPSDQGKGKARPPEPLSSKPPLPRKPLLQSFTLPHQPAPPDAGPG------- 785

Query: 870 SLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKE 929
               E     EPR         E +P    A+K  SL         + +    W  V ++
Sbjct: 786 ----EREPRKEPRTA-------EKRPLRRGAEK--SLPPAATGPGADGQPAPPWITVTRQ 832

Query: 930 QRREEAARLA-QEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQE 981
           +RR    +   QE+ PG   L S      P   A+ P   +   ++ DF R +
Sbjct: 833 KRRGTLDQPPNQEDKPGARTLKS-----EPGKQAKVPERGQEPVKQADFVRSK 880



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 138/562 (24%), Positives = 187/562 (33%), Gaps = 74/562 (13%)

Query: 449 PPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLH--SPEGPSKPSLASP-YLPEGT 505
           PPP PG LP  +       S+E   LP    + S  LH   P    K S+ SP ++ + T
Sbjct: 136 PPPPPGGLPA-KRGEDAGMSSEDDGLPRSPPEMSL-LHDVGPGTTIKVSVVSPDHVSDST 193

Query: 506 SKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASK-----PPAPSEGSPKAVASSPAATNS 560
                   + APV       P++ S CL   A+K      P     S     SS A + S
Sbjct: 194 VSARISDNSLAPV--ADFSYPAESSSCLDNSAAKHKLQVKPRNQRSSKMRRLSSRAQSES 251

Query: 561 EVKMTSFAERKKQLVKAEAEAGAGSPTST------------PAPPEALSSEMSELSARLE 608
              +T   E ++   K   E       S+            P PP  L            
Sbjct: 252 LSDLTCTPEEEENEEKPLLEVSPEERPSSGQQDVAPDRGPEPGPPAPLPPP--------- 302

Query: 609 EKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPRE--ASGEAEAEAEEADSGPVPGGER 666
                  A++ R++     H   L  S      P E  +S  A  E  E +S P    E 
Sbjct: 303 ---GGARARRARLQ-----HSSALTASVEEGGVPGEDPSSRPATPELAEPESAPTLRVE- 353

Query: 667 PAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL-TDQQQ 725
           P    +G P   P       +  P      G    A  K    + + +       T   +
Sbjct: 354 PPSPPEGPPNPGPDGGKQDGEAPPA-----GPCAPATDKAEEVVCAPEDVASPFPTAIPE 408

Query: 726 RLLAPPEAPGSAPPPAAWVIPGPTTG-PKAASPSPARRVPATRRSPGPGP------SQSP 778
               PPE   +A   A     GP    PK A P+P       +  PGP P         P
Sbjct: 409 GDTTPPETDPAATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPEREAETEP 468

Query: 779 RSPKHTRPAELRLAPLTR-VLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
                T P  +   P T    +PP     L H R  + S+ P    S  L A E+PP EP
Sbjct: 469 ERGAGTEPERIGTEPSTAPAPSPPAPKSCLKH-RPAAASEGP--AASPPLAAAESPPVEP 525

Query: 838 AARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRV-GLGFFYKDEDKPE 896
              PG ++    +   P AE   +  PAGAE +  E  +  G   + G   F     +  
Sbjct: 526 G--PGSLDAEAAAPERPKAE-RAEAPPAGAERAAPERKAERGGAELRGAKKFSVSSCRAR 582

Query: 897 DEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPM- 955
                 R   LER   R   AR    W+  E      +     Q   PGP  L    P  
Sbjct: 583 PRPGVSRP--LERASGRLPLARSGPVWRS-EAALDDLQGLPEPQHAKPGPRKLAERGPQD 639

Query: 956 -----ATPAPAARAPAEEEVGP 972
                A+PA   ++P E    P
Sbjct: 640 SGDRAASPAGPRKSPQEAAAAP 661


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 133/574 (23%), Positives = 187/574 (32%), Gaps = 101/574 (17%)

Query: 330 GHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSP-------- 381
           G A  P     + P  ++G+SS     R P    G    P + ++    SSP        
Sbjct: 66  GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125

Query: 382 -----------SMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLR-- 428
                      S     A GKA        LS      T     S        P + R  
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDT-----SGPTPGTPSPAMARRS 180

Query: 429 SVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHS-AEPRLLPDGAADGSFYLHS 487
             +   +G PRPAP+  P   PP  G   ++  A +  HS  EP             L  
Sbjct: 181 RAAGTEVGLPRPAPSARPR--PPTEGPRKSVSSASE--HSTTEPSPAARRRPSAGGGLQR 236

Query: 488 PEGPSKPSLASPYLPEGTSKPLSDRPTKAPVY--MPHPETPSKPSPCLVGEASKPPAPSE 545
           P   S  S A+P      S P +    +AP +   P P+      P  V    K  AP+ 
Sbjct: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296

Query: 546 G----SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMS 601
           G    SP A  S  AA  S+   T  A      +  +          +P+ P +L +  S
Sbjct: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356

Query: 602 ELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPV 661
             +    +   ++ +       + A H       +FL   P         +A  A + P 
Sbjct: 357 PPATPPSQATTSLGS-----PTLQATH-------SFLPSPPLSPLATPPPQAPPALALP- 403

Query: 662 PGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNR-AVSKLSAALSSLQRDMQRL 720
                        P   P +   SP L P+        N  AV  L A  S         
Sbjct: 404 -------------PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS--------- 441

Query: 721 TDQQQRLLAPPEAPGSAP--PPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSP 778
                    PP  P  AP  PPA+  +    T P  A PS A   P  +  P P P+  P
Sbjct: 442 --------PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA--APPLQVPPSP-PASPP 490

Query: 779 RSPKHTRPAE----LRLAPLTRVLTPPH--------DVDSLPHLRKFSPSQVPVQTRSSI 826
            SP  T P +    L   PL     PP          + +LP      P Q P    +S+
Sbjct: 491 MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 550

Query: 827 LLAE-ETPPEE--PAARPGLIEIPLGSLADPAAE 857
            ++   TPP +  P     L+++P    A P  +
Sbjct: 551 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 584



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 180/814 (22%), Positives = 248/814 (30%), Gaps = 171/814 (21%)

Query: 437  PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
            P   AP     +PP  P   P +  A   +  A   +     A+ +  +     P     
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 497  ASPYLPEGTSK-------PLSDRPTKAPVYMPHPETPSKPSPCLV-GEASKPPAPSEGSP 548
            A P    GTS        P S R  +AP     P   + P P    G AS    P     
Sbjct: 77   AGPTRSAGTSSRNPASRPPASGRGERAP-----PAKNTSPGPVSSPGRASGTTRPGPLGQ 131

Query: 549  KAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARL- 607
            K +  S   T +  K T   +R      A  +    +P  TP+P  A  S  +     L 
Sbjct: 132  KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-GTPSPAMARRSRAAGTEVGLP 190

Query: 608  ------------EEKRRAIEAQKRR--IEAIFAKHRQRLGKSAFLQVQPREASGEAEAEA 653
                        E  R+++ +       E   A  R+        +   R  S  A   +
Sbjct: 191  RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250

Query: 654  EEADSGPVPGG--ERPAGEGQGEPTS----RPKAVT-----FSPDLGPVPHEGLGEYNRA 702
              A SGP   G    PA   Q +P      RP  VT      +P LGP+    L     A
Sbjct: 251  SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL-----A 305

Query: 703  VSKLSAALSSLQRDMQRLTDQQQRL---------LAPPE-----------APGSAPPPAA 742
                SAAL S        T     L         LAPP            +P + PP  A
Sbjct: 306  TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQA 365

Query: 743  WV-------------IPGPTTGPKAASP---SPARRVPATRRSPGPGPS----------- 775
                           +P P   P A  P    PA  +P  +  P P  S           
Sbjct: 366  TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSP 425

Query: 776  -----------QSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRS 824
                       Q+P SP  + P +   AP +   +PP    + P      PSQ P    +
Sbjct: 426  QAPNALAVHLLQAPFSPPPSPPVQ---APFSPPASPPVSPSATP------PSQAPPSLAA 476

Query: 825  SILLAEETPPEEPAARPGLIEIPLG--SLADP---AAEDEGDGSPAGAEDSLE----EEA 875
              L    +PP  P   P     P     LA P    A+      PA A   L+      A
Sbjct: 477  PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPA 536

Query: 876  SSEGE----PRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQR 931
            S  G+    P   L         P+         L       A    +  +         
Sbjct: 537  SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 596

Query: 932  REEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLM 991
                 RL    APGP           P P +R+P+    GP     +        +L+  
Sbjct: 597  SVSGPRLTLALAPGP-----------PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 645

Query: 992  DDLDKVLRPRAAGSGGPGRGGRRATRP---RSGCCDDSALARSPA-----RGLLGSRL-- 1041
            D              GP  GG  A+ P       C  +A +R PA     RG  G+ L  
Sbjct: 646  D-------------SGP-EGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPW 691

Query: 1042 -SKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSRERDWENGSNASS 1100
                   S   L T+          + P S  P+P G + P   PG+       G+ A +
Sbjct: 692  PPATGPGSADGLCTIYE-------TEGPESATPAP-GALDPGPSPGTSGGKAAAGAGAGA 743

Query: 1101 PASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCL 1134
             +  P+    RL + P       ++ + LS   L
Sbjct: 744  SSRSPKQA--RLGELPLGALQASVVQHLLSRTLL 775



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 132/557 (23%), Positives = 176/557 (31%), Gaps = 130/557 (23%)

Query: 334 SPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSP--------SMSH 385
           S R   + PP +  G  +P      P     GP S    ++G+ +  P        S   
Sbjct: 86  SSRNPASRPPASGRGERAPPAKNTSP-----GPVSSPGRASGTTRPGPLGQKGLRISAEE 140

Query: 386 MEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRS--VSSDSLGPPRPAPA 443
             A GKA        LS      T     S        P + R    +   +G PRPAP+
Sbjct: 141 TVARGKATEAPKRSALSAGARRDT-----SGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195

Query: 444 RTP-------------------TQPPPEPGDLPTIEEALQ------IIHSAEPRLLPDGA 478
             P                   T+P P     P+    LQ      +  SA P   P  A
Sbjct: 196 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP--A 253

Query: 479 ADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTK--APVYMPHPETP-SKPSPCLVG 535
             G     +P  P+ PS   P   +    P    P K  AP   P   +P + PSP    
Sbjct: 254 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAAL 313

Query: 536 EASKPPA----------------------PSEGSPKAVAS--SPAATNSEVKMTSFAERK 571
           ++  PP                       PS  +P ++ +  SP AT      TS     
Sbjct: 314 QSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 373

Query: 572 KQLVKAEAEAGAGSPTSTPAP--PEAL-------------SSEMSELSARLEEKRRAIEA 616
            Q   +   +   SP +TP P  P AL             S  +S L+    +   A+  
Sbjct: 374 LQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAV 433

Query: 617 QKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERP--AGEGQGE 674
               ++A F+               P +A     A    + S   P    P  A      
Sbjct: 434 HL--LQAPFSPPPS----------PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 481

Query: 675 PTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEA- 733
           P S P +   SP   P P         A   L  A    Q      T   Q L +PP + 
Sbjct: 482 PPSPPASPPMSPSATPPPQ---APPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF 538

Query: 734 PGSAP-------PPAAWVIPGPTTGPKAASP----------SPARRVPATRRSPGPGPSQ 776
           PG AP       P +    P P   P  A+P          SP  + P  RR P PGP  
Sbjct: 539 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP--RRPPTPGPDT 596

Query: 777 SPRSPKHTRPAELRLAP 793
           S   P+ T    L LAP
Sbjct: 597 SVSGPRLT----LALAP 609



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 161/700 (23%), Positives = 231/700 (33%), Gaps = 103/700 (14%)

Query: 97  TPPNPSALLALLARR-GTVPALPERPVREADLRHQPILMGAHLAVIDALMAAFAFEWTKT 155
           TP  PS  +A  +R  GT   LP RP   A  R +P   G   +V      + A E + T
Sbjct: 168 TPGTPSPAMARRSRAAGTEVGLP-RPAPSA--RPRPPTEGPRKSV------SSASEHSTT 218

Query: 156 LPGPLALT------SLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIR 209
            P P A         L+      + ++   L        + R +P APA  + P    ++
Sbjct: 219 EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQ 278

Query: 210 -YRKDRVVARRAPCFPTVTSLQD--LASGAALAATIHCYCPQLLRLEEVCLKDPMSVADS 266
             R  +V   R    P +  L    LA+ +  AA +    P  L         P +   S
Sbjct: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAA-LQSQAPPTL---------PATPHSS 328

Query: 267 LYNLQLVQDFCASRLPRGCPLSLEDLLYVP--PPLKVNL-----VVMLAELFMCFEVLKP 319
               QL      +      P SL+ L   P  PP +         +     F+    L P
Sbjct: 329 SLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 388

Query: 320 DFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKS 379
                   P   A  P     SPP   S   SP        L++  PQ+P   +   L++
Sbjct: 389 LATPPPQAPPALALPPLQAPPSPPA--SPPLSP--------LATPSPQAPNALAVHLLQA 438

Query: 380 SPSMSHMEALGKAWNRQLSRPLSQAVS--FSTPFGLDSDVDVVMGDPVLLRSVSSDSLGP 437
             S      +   ++   S P+S + +     P  L +    V   P     +S  +  P
Sbjct: 439 PFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP 498

Query: 438 PRPAP---------ARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLP--DGAADGSFYLH 486
           P+  P         A+ P Q PP     P   +AL    ++ P   P    A+     L 
Sbjct: 499 PQAPPPLAAPPLQLAKPPPQAPPALATPPL--QALPSPPASFPGQAPFSPSASLPMSPLA 556

Query: 487 SPEGPSKPSLASPYL---PEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAP 543
           +P   + P LA+P L   P   + P    P + P   P P+T        +  A  PP P
Sbjct: 557 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT--PGPDTSVSGPRLTLALAPGPPPP 614

Query: 544 SEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSEL 603
              SP +  S P         TS  E  +          A SP     PP+A   E++  
Sbjct: 615 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASP-----PPDA---ELAAC 666

Query: 604 SARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSA---FLQVQPREASGEAEAEAEEADSGP 660
                 +  A     R             G  +      +   E    A       D GP
Sbjct: 667 HPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP 726

Query: 661 VP---GGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDM 717
            P   GG+  AG G G  +  PK       LG +P                 L +LQ  +
Sbjct: 727 SPGTSGGKAAAGAGAGASSRSPKQAR----LGELP-----------------LGALQASV 765

Query: 718 QRLTDQQQRLLAPPE--APGSAPPPAAWVIPGPTTGPKAA 755
            +    +  LLA  E  A GS   P      G T G +AA
Sbjct: 766 VQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAA 805


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 132/528 (25%), Positives = 183/528 (34%), Gaps = 104/528 (19%)

Query: 363 SGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQ-----LSRPLSQAVSFS-TPFGLDSD 416
           S  P+ P  G   S+ S+   S  E    A  R      L RP S+++S S TP    + 
Sbjct: 195 SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA- 253

Query: 417 VDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPD 476
                      RS  S + G PR APA  P+QP P+        +       A P L P 
Sbjct: 254 -----------RSGPS-ARGTPR-APAH-PSQPKPKGLQALRPPQVTPPRKDAAPALGP- 298

Query: 477 GAADGSFYLHSPEGPSKPSLASPYLPEGTSKPL-SDRPTKAPVYMPHPETPSKPS--PCL 533
             +       SP G +K     P  P+  + PL +  P   P+  P P  P  PS  P L
Sbjct: 299 -LSSSPLATPSPSG-TKARPVPP--PDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSL 354

Query: 534 VGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPP 593
               S P  P   +P ++ + P      ++     +    L          SP S  APP
Sbjct: 355 QTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLT---------SP-SLQAPP 404

Query: 594 EALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEA 653
             L+  +S L A        ++A                   +FL + PR+      + +
Sbjct: 405 SPLA--LSSLQATTSLGSPTLQATH-----------------SFLTMSPRQTQASLTSPS 445

Query: 654 EEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLS-----A 708
             A + P      P       P S P   + SP + P+         +A+S L+     A
Sbjct: 446 RPASTPP---DSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQA 502

Query: 709 ALSSLQRDMQRLTDQQQRLLAPPEA---------------PGSAPPPAAWVIPGPTTG-- 751
            LSSL   M  L  Q    LAPP                 P  APPP        TT   
Sbjct: 503 PLSSLI--MPPLETQSS--LAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHL 558

Query: 752 --PKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPH 809
             P   +P P +  P+   +P P    S  +P    P  L   PL  + +PP    + P 
Sbjct: 559 ETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATP- 617

Query: 810 LRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAE 857
                P Q P       L A  +PP  P         PL  LA P+ +
Sbjct: 618 -----PPQAPPXLALPPLQAPPSPPASP---------PLSPLATPSPQ 651



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 126/493 (25%), Positives = 169/493 (34%), Gaps = 106/493 (21%)

Query: 334 SPRGTEASPPQNNSGS------SSPVFTFRHPL-----LSSGGPQSPLRGSTGSLKSSPS 382
           +P    ASPP   S S      SSP+    HPL     L+S  PQ+PL        SS  
Sbjct: 459 APLSLPASPPLQTSLSPAVSPLSSPLTI--HPLQALSSLASHSPQAPL--------SSLI 508

Query: 383 MSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGP---PR 439
           M  +E         L  P     S +TP  L++   +    P  L++ S+    P     
Sbjct: 509 MPPLETQSSLAPPSLQTP---PASLTTP-PLENLPSLA---PPPLQTASAPLTTPHLETP 561

Query: 440 PAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFY---------LHSPEG 490
           P PA  P Q PP P   P  E    I  +  P   P   A              L +P  
Sbjct: 562 PCPAPCPLQAPPSPLTTPPPETPSSI--ATPPPQAPPALASPPLQGLPSPPLSPLATPPP 619

Query: 491 PSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLV-GEASKPPAPSEGSPK 549
            + P LA P L    S P S  P  +P+  P P+ P+  +  L+    S PP+P   +P 
Sbjct: 620 QAPPXLALPPLQAPPSPPAS--PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 677

Query: 550 AVASSP----AATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAP--PEALSSEMSEL 603
           +  +SP    +AT       S A    Q+  +   +   SP++TP P  P  L++   ++
Sbjct: 678 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQV 737

Query: 604 --SARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPR-EASGEAEAEAEEADSGP 660
             S               R+  + A        +  LQV P   AS      A+     P
Sbjct: 738 PPSPPASPPMSPSATPPPRVPPLLA--------APPLQVPPSPPASLPMSPLAKPPPQAP 789

Query: 661 VPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
                 P       P S P    FSP                    S  +S L       
Sbjct: 790 PALATPPLQALPSPPASFPGQAPFSP------------------SASLPMSPL------- 824

Query: 721 TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRS 780
                    PP+AP     P   V P P   P   +P         RR P PGP  S   
Sbjct: 825 ------ATPPPQAPPVLAAPLLQVPPSPPASPTLQAP---------RRPPTPGPDTSVSG 869

Query: 781 PKHTRPAELRLAP 793
           P+ T    L LAP
Sbjct: 870 PRLT----LALAP 878



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 195/887 (21%), Positives = 275/887 (31%), Gaps = 174/887 (19%)

Query: 328  PDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHME 387
            P     S RGT  +P   +      +   R P ++   P+     + G L SSP  +   
Sbjct: 252  PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP--PRKDAAPALGPLSSSPLATPSP 309

Query: 388  ALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPV-----------LLRSVSSDSLG 436
            +  KA      RP+    + +TP          +  P+            L+++ S    
Sbjct: 310  SGTKA------RPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPAT 363

Query: 437  PPRPAPARTPTQPPPEPGDLPTIEEALQIIHS-------AEPRLL-------------PD 476
            PP  AP    T P   P  L TI   +Q+ HS       A P  L             P 
Sbjct: 364  PPSQAPPSMTTPPMQAPPSLQTIPP-IQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPT 422

Query: 477  GAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMP---------HPETPS 527
              A  SF   SP   ++ SL SP  P  T  P    P +AP+ +P          P    
Sbjct: 423  LQATHSFLTMSPR-QTQASLTSPSRPAST--PPDSPPLQAPLSLPASPPLQTSLSPAVSP 479

Query: 528  KPSPCLVGEASKPPAPSEGSPKAVASS----PAATNSEVKMTSFAERKKQLVKAEAE--- 580
              SP  +       + +  SP+A  SS    P  T S +   S       L     E   
Sbjct: 480  LSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLP 539

Query: 581  -------AGAGSPTSTP-------APPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFA 626
                     A +P +TP         P  L +  S L+    E   +I     +     A
Sbjct: 540  SLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALA 599

Query: 627  KHRQRLGKSAFL--------QVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSR 678
                +   S  L        Q  P  A    +A      S P+     P+ +        
Sbjct: 600  SPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 659

Query: 679  PKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAP 738
                 FSP   P                SA   S              L APP     +P
Sbjct: 660  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS---------QAPPSLAAPPLQVPPSP 710

Query: 739  PPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVL 798
            P +  + P  T  P+A  P  A   P  +  P P P+  P SP  T P   R+ PL  + 
Sbjct: 711  PASPPMSPSATPPPQAPPPLAA---PPLQVPPSP-PASPPMSPSATPPP--RVPPL--LA 762

Query: 799  TPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAED 858
             PP  V   P      P+ +P+   +        PP  P A P L   PL +L  P A  
Sbjct: 763  APPLQVPPSP------PASLPMSPLAK-------PP--PQAPPALATPPLQALPSPPASF 807

Query: 859  EGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEAR 918
             G  +P     SL     +   P+            P    A        R      +  
Sbjct: 808  PGQ-APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT- 865

Query: 919  RRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFT 978
                              RL    APGP           P P +R+P+    GP     +
Sbjct: 866  -------------SVSGPRLTLALAPGP-----------PPPPSRSPSSTLSGPDLAGHS 901

Query: 979  RQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRP---RSGCCDDSALARSPA-- 1033
                    +L+  D              GP  GG  A+ P       C  +A +R PA  
Sbjct: 902  SSATSTPEELRGYD-------------SGP-EGGAAASPPPDAELAACHPAAWSRGPAPP 947

Query: 1034 ---RGLLGSRL---SKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGS 1087
               RG  G+ L         S   L T+          + P S  P+P G + P   PG+
Sbjct: 948  LAFRGAPGAPLPWPPATGPGSADGLCTIYE-------TEGPESATPAP-GALDPGPSPGT 999

Query: 1088 RERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCL 1134
                   G+ A + +  P+    RL + P       ++ + LS   L
Sbjct: 1000 SGGKAAAGAGAGASSRSPKQA--RLGELPLGALQASVVQHLLSRTLL 1044



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 178/758 (23%), Positives = 236/758 (31%), Gaps = 119/758 (15%)

Query: 91   ALPQLETPPNPSALLALLARRGTVPALPERPVREA--DLRHQPILMGAHLAVIDALMAAF 148
            A P    PP+PSA  +L     T+P+ P  P  +A   +   P+     L  I  +    
Sbjct: 338  ATPLPLAPPSPSAPPSLQ----TLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPH 393

Query: 149  AFEWT--KTLPGPLALTSLEHKLLFWVDT---TVRRLQEKTEQEAAQRASPAAPADGAAP 203
            +      +  P PLAL+SL+        T   T   L     Q  A   SP+ PA    P
Sbjct: 394  SLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAS-TPP 452

Query: 204  AQPSIRYRKDRVVARRAPCFPTV-TSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMS 262
              P ++           P  P + TSL    S  +   TIH     L  L  +    P +
Sbjct: 453  DSPPLQ------APLSLPASPPLQTSLSPAVSPLSSPLTIH----PLQALSSLASHSPQA 502

Query: 263  VADSLYNLQL-VQDFCASRLPRGCPLSL-----EDL-LYVPPPLKVNLVVMLAELFMCFE 315
               SL    L  Q   A    +  P SL     E+L    PPPL+     +         
Sbjct: 503  PLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPP 562

Query: 316  VLKPDFVQVKDLP--DGHAASPRGTEASPPQNNSGSSSPVFTF--RHPL--LSSGGPQSP 369
               P  +Q    P       +P      PPQ     +SP        PL  L++  PQ+P
Sbjct: 563  CPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAP 622

Query: 370  LRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSF-STPFGLDSDVDVVMGDPVLLR 428
               +   L++ PS      L          P + AV     PF       V         
Sbjct: 623  PXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 682

Query: 429  SVSSDSLGPPRPAP---ARTPTQPPPEPGDLPTIEEALQIIHSAEPRLL-PDGAADGSFY 484
               S S  PP  AP   A  P Q PP P   P +  +      A P L  P      S  
Sbjct: 683  PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPP 742

Query: 485  LHSPEGPSK-------PSLASPYLPEGTS-------KPLSDRPTKAPVYMPHPETPSKPS 530
               P  PS        P LA+P L    S        PL+  P +AP  +  P   + PS
Sbjct: 743  ASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPS 802

Query: 531  PCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTP 590
            P        P +PS   P +  ++P      V           L++      A      P
Sbjct: 803  PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA-------PLLQVPPSPPASPTLQAP 855

Query: 591  APPEALSSEMSELSARLE-EKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEA 649
              P     + S    RL             R  +         G S+     P E  G  
Sbjct: 856  RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 915

Query: 650  EAEAEEADSGPVPGGERPA------GEGQGEPTSRPKA----VTFSPDLGPVPHEGLGEY 699
                  A + P P  E  A        G   P +   A    + + P  GP   +GL   
Sbjct: 916  SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGL--- 972

Query: 700  NRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGP---TTGPKAAS 756
                                        +   E P SA P    + PGP   T+G KAA+
Sbjct: 973  --------------------------CTIYETEGPESATPAPGALDPGPSPGTSGGKAAA 1006

Query: 757  PSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPL 794
                          G G   S RSPK  R  EL L  L
Sbjct: 1007 --------------GAGAGASSRSPKQARLGELPLGAL 1030



 Score = 34.7 bits (78), Expect = 0.58
 Identities = 65/261 (24%), Positives = 88/261 (33%), Gaps = 50/261 (19%)

Query: 735 GSAPPPAAWVIPGPTTGPKAASPSPARRVPATRR--------SPGPGPSQSP-RSPKHTR 785
           G A  P +    GPT     +S +PA R PA+ R        +  PGP  SP R+   TR
Sbjct: 66  GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125

Query: 786 P-----------AELRLAPLTRVLTPPHDVDSLPHLRKFS----PSQVPVQTRSSILLAE 830
           P           AE  +A       P     S    R  S     +  P   R S     
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 831 ET--PPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFF 888
           E   P   P+ARP            P        S A    + E   ++   P  G G  
Sbjct: 186 EVGLPRPAPSARP----------RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL- 234

Query: 889 YKDEDKPEDEMAQKRASLLERQQRRAEEAR--RRKQWQEVEKEQRREEAARLAQ------ 940
                +P        A+ L    R    AR   R      + + +  +A R  Q      
Sbjct: 235 ----QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 290

Query: 941 EEAPGPAPLVSAVPMATPAPA 961
           + AP   PL S+ P+ATP+P+
Sbjct: 291 DAAPALGPL-SSSPLATPSPS 310



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 66/258 (25%), Positives = 84/258 (32%), Gaps = 76/258 (29%)

Query: 657 DSGPVPGGERPAGEGQGEPTSRPKA--------VTFSPDLGPVPHEG----------LGE 698
           +S P  G  R AG     P SRP A           +   GPV   G          LG+
Sbjct: 72  ESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 131

Query: 699 YNRAVS--------------KLSAALSSLQRDMQRLTD-------QQQRLLAPPEAPGSA 737
               +S              K SA  +  +RD    T         ++   A  E     
Sbjct: 132 KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 191

Query: 738 PPPAAWVIPGPTTGPK-----AASPSPARRVPATRRSP---------------------- 770
           P P+A   P PT GP+     A+  S     PA RR P                      
Sbjct: 192 PAPSARPRP-PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250

Query: 771 -----GPGPSQSPRSPKH-TRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRS 824
                GP    +PR+P H ++P    L  L      P   D+ P L   S S  P+ T S
Sbjct: 251 SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS--PLATPS 308

Query: 825 -SILLAEETPPEEPAARP 841
            S   A   PP + AA P
Sbjct: 309 PSGTKARPVPPPDNAATP 326


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 129/511 (25%), Positives = 178/511 (34%), Gaps = 97/511 (18%)

Query: 482 SFYLHSPEGPSKPSLASPYLPEGTSKPLSD------RPTKAPVYMPHPET-PSKPSPCLV 534
           SF   + +GP  P L    L E  + P+        +   A +  P  E  P+K  P LV
Sbjct: 217 SFTQETKKGP--PVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLV 274

Query: 535 GEASKP--PAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSP-TSTPA 591
            EA+    P P+E +   V  S   T      T+ AE     VK +      +P    PA
Sbjct: 275 EEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENS---VKVQPPPAEEAPLVEFPA 331

Query: 592 ---PPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGE 648
              PP A  S   EL A                                 ++ P  A  E
Sbjct: 332 EIQPPSAEESPSVELLA---------------------------------EILPPSAE-E 357

Query: 649 AEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSA 708
           + +E   A+  P P  + P+ E  GE  S P A     ++ P+P EG             
Sbjct: 358 SPSEEPPAEILPPPAEKSPSVELLGEIRS-PSAQKAPIEVQPLPAEG------------- 403

Query: 709 ALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRR 768
           AL      ++  T ++      P  P  AP   A  +   T     A  +PA   P   +
Sbjct: 404 ALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLST-----AMETPAEEAPTEFQ 458

Query: 769 SPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSL----PHLRKFSPSQVPVQTRS 824
           SP P  + +  +      AE++L   T    PP D        P   + S  +   + +S
Sbjct: 459 SPLPKETTAEEAS-----AEIQLLAATE---PPADETPAEARSPLSEETSAEEAHAEVQS 510

Query: 825 SILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVG 884
              LAEET  EE +A   L+          A E   D +PA A+  L EE S+E  P   
Sbjct: 511 P--LAEETTAEEASAEIQLLA---------AIEAPADETPAEAQSPLSEETSAEEAPAEV 559

Query: 885 LGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAP 944
                K     E  +  +  S  E     A  A +     E   E+   E      EEAP
Sbjct: 560 QSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAP 619

Query: 945 G---PAPLVSAVPMATPAPAARAPAEEEVGP 972
               P P   A     P PA  APAE +  P
Sbjct: 620 AEVQPPPAEEAPAEVQPPPAEEAPAEVQPPP 650



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 123/541 (22%), Positives = 190/541 (35%), Gaps = 111/541 (20%)

Query: 438 PRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFY-----LHSPEGPS 492
           PRPA   T  Q  P   + P  E A  +  ++  ++ P  A +         +  P    
Sbjct: 283 PRPAE-ETHVQVQPSTEETPDAEAATAVAENSV-KVQPPPAEEAPLVEFPAEIQPPSAEE 340

Query: 493 KPS--LASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKP---------- 540
            PS  L +  LP    +  S+ P   P  +  P     PS  L+GE   P          
Sbjct: 341 SPSVELLAEILPPSAEESPSEEP---PAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQ 397

Query: 541 PAPSEGSPKAVASSPAATNSEVKMTSFAE--------------RKKQLVKAEAEAGAGSP 586
           P P+EG   A+  +PA         + A+              R+ QL  A       +P
Sbjct: 398 PLPAEG---ALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAP 454

Query: 587 TS--TPAPPEALSSEMS------------------ELSARLEEKRRAIEAQKRRIEAIFA 626
           T   +P P E  + E S                  E  + L E+  A EA    +++  A
Sbjct: 455 TEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAE-VQSPLA 513

Query: 627 KHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSP 686
           +       SA +Q+    A+ EA A+   A++      E  A E   E  S P A   S 
Sbjct: 514 EETTAEEASAEIQLL---AAIEAPADETPAEAQSPLSEETSAEEAPAEVQS-PSAKGVSI 569

Query: 687 DLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPP--EAPGSAPPPAAWV 744
           +  P+  +          + SAA+  L        +    +  PP  EAP    PP A  
Sbjct: 570 EEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEE 629

Query: 745 IPGPTTGPKA------ASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVL 798
            P     P A        P PA   PA  + P          P    PAE++  P     
Sbjct: 630 APAEVQPPPAEEAPAEVQPPPAEEAPAEVQPP----------PAEEAPAEVQPPPAEEA- 678

Query: 799 TPPHDVDSLPHLRKFSPSQVPVQTRSSIL---LAEETPPEE--------PAARPGLIEIP 847
             P +V SLP        + P++   + +    A++ P EE        PA      E P
Sbjct: 679 --PAEVQSLP------AEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEFP 730

Query: 848 LGSLADPAAEDEGDGSPAGAEDSLEEEASSE-------GEPRVGLGFFYKDEDKPEDEMA 900
           +G  +   +    + +P   +++L E  S+E       G P V LG    + +   +E++
Sbjct: 731 IGEASAEVSPPPSEQTP--EDEALVENVSTEFQSPQVAGIPAVKLGSVVLEGEAKFEEVS 788

Query: 901 Q 901
           +
Sbjct: 789 K 789


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 98/421 (23%), Positives = 141/421 (33%), Gaps = 43/421 (10%)

Query: 429 SVSSDSLGPPRPAPARTPTQP--PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLH 486
           ++ S    P  PAP  T + P  P EP    T E A        P    + A   +    
Sbjct: 236 TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT--KS 293

Query: 487 SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
           +P  P +P+  +P  P  T+ P    PT      P P TP +P+P     A  P  P E 
Sbjct: 294 APTTPKEPAPTTPKKPAPTT-PKEPAPTTPKE--PTPTTPKEPAPTTKEPA--PTTPKEP 348

Query: 547 SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTS--TPAPPEALSSEMSELS 604
           +P A       T  E   T+  E      K        SPT+   PAP    S+  +   
Sbjct: 349 APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKE 402

Query: 605 ARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-G 663
                 + A    K        +      K        + A    +  A      P P  
Sbjct: 403 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 462

Query: 664 GERPAGEGQGEP---TSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
            ++PA     EP   T +  A T    L P   E               L+    +    
Sbjct: 463 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE--------------KLAPTTPEKPAP 508

Query: 721 TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASP-SPARRVPATRRSPGPGPSQ--S 777
           T  ++     PE P    P      P PTT PKAA+P +P    P T + P P   +  +
Sbjct: 509 TTPEELAPTTPEEPTPTTPEE----PAPTT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPA 563

Query: 778 PRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
           P +PK T P   +    T +  P       P  ++ +P+     T ++      T P+  
Sbjct: 564 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623

Query: 838 A 838
           A
Sbjct: 624 A 624



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 79/359 (22%), Positives = 120/359 (33%), Gaps = 34/359 (9%)

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAV 551
           +KP+  +    +G +      PT      P   TP +P+P  +  A  P  P E +P   
Sbjct: 195 AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--PTTPKEPAPTTT 252

Query: 552 ASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKR 611
            S+P         T+     K+      +  A + T  PAP        +  SA    K 
Sbjct: 253 KSAPTTPKEPAPTTT-----KEPAPTTPKEPAPTTTKEPAPT-------TTKSAPTTPKE 300

Query: 612 RAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGG-ERPAGE 670
            A    K+       +      K       P+E +   +  A      P P   ++PA  
Sbjct: 301 PAPTTPKKPAPTTPKEPAPTTPKEP-TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT 359

Query: 671 GQGEP---TSRPKAVTFSPDLGPV-PHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQR 726
              EP   T +  A T + +  P  P E      ++    +   +         T ++  
Sbjct: 360 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE-- 417

Query: 727 LLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQ-----SPRSP 781
              P       P P     P PTT  K A  +P    P T + P P  ++     +P+ P
Sbjct: 418 ---PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 474

Query: 782 KHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP--PEEPA 838
             T P E   AP T     P   + L       P+    +  +     E TP  PEEPA
Sbjct: 475 APTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 531



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 82/407 (20%), Positives = 127/407 (31%), Gaps = 35/407 (8%)

Query: 437 PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
           P  PAP  T + P       PT  ++                A  +    +P  P KP+ 
Sbjct: 385 PKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP 444

Query: 497 ASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPA 556
            +P  P  T+ P    PT      P P TP +P+P    E + P  P + +P        
Sbjct: 445 TTPKEPAPTT-PKEPAPTTTK--KPAPTTPKEPAPTTPKETA-PTTPKKLTPTTPEKLAP 500

Query: 557 ATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAP--PEALSSEMSELSARLEEKRRAI 614
            T  +   T+     ++L     E    +    PAP  P+A +    +  A    K  A 
Sbjct: 501 TTPEKPAPTT----PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 556

Query: 615 EAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-GGERPAGEGQG 673
              K                +   +  P    G A    +E    P P   ++PA +   
Sbjct: 557 TTPKEP------------APTTPKETAPTTPKGTAPTTLKE----PAPTTPKKPAPKELA 600

Query: 674 EPTSRPKAVTFSPDLGPVPHEGLG---EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAP 730
             T++    T      P   +G         A +       +  +     T ++     P
Sbjct: 601 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP 660

Query: 731 PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELR 790
            +       P     P  TT  K A  +P    P T + P P    +P+ P  T P    
Sbjct: 661 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP---TTPKKPAPTTPE--T 715

Query: 791 LAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
             P T  ++ P        + K      P  +      A E  P+EP
Sbjct: 716 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 762



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 45/188 (23%), Positives = 68/188 (36%), Gaps = 16/188 (8%)

Query: 437 PPRPAPARTPTQPPPEP--GDLPTI--EEALQIIHSAEPRLLPDGAADGSFYLHSPE-GP 491
           P  PAP  TP +P P    G  PT   E A        P+ L      G     S +  P
Sbjct: 628 PKEPAPT-TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 686

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEA---------SKPPA 542
           + P   +P  P+  +     +P       P P T    +P    E          S P  
Sbjct: 687 TTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 746

Query: 543 PSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSE 602
            +E +PKA+ +SP         T  A + +    A+ +       +TP    A + +M++
Sbjct: 747 SAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA-APKMTK 805

Query: 603 LSARLEEK 610
            +A   EK
Sbjct: 806 ETATTTEK 813


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 98/421 (23%), Positives = 141/421 (33%), Gaps = 43/421 (10%)

Query: 429 SVSSDSLGPPRPAPARTPTQP--PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLH 486
           ++ S    P  PAP  T + P  P EP    T E A        P    + A   +    
Sbjct: 277 TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT--KS 334

Query: 487 SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
           +P  P +P+  +P  P  T+ P    PT      P P TP +P+P     A  P  P E 
Sbjct: 335 APTTPKEPAPTTPKKPAPTT-PKEPAPTTPKE--PTPTTPKEPAPTTKEPA--PTTPKEP 389

Query: 547 SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTS--TPAPPEALSSEMSELS 604
           +P A       T  E   T+  E      K        SPT+   PAP    S+  +   
Sbjct: 390 APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKE 443

Query: 605 ARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-G 663
                 + A    K        +      K        + A    +  A      P P  
Sbjct: 444 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 503

Query: 664 GERPAGEGQGEP---TSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
            ++PA     EP   T +  A T    L P   E               L+    +    
Sbjct: 504 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE--------------KLAPTTPEKPAP 549

Query: 721 TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASP-SPARRVPATRRSPGPGPSQ--S 777
           T  ++     PE P    P      P PTT PKAA+P +P    P T + P P   +  +
Sbjct: 550 TTPEELAPTTPEEPTPTTPEE----PAPTT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPA 604

Query: 778 PRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
           P +PK T P   +    T +  P       P  ++ +P+     T ++      T P+  
Sbjct: 605 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664

Query: 838 A 838
           A
Sbjct: 665 A 665



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 79/359 (22%), Positives = 120/359 (33%), Gaps = 34/359 (9%)

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAV 551
           +KP+  +    +G +      PT      P   TP +P+P  +  A  P  P E +P   
Sbjct: 236 AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--PTTPKEPAPTTT 293

Query: 552 ASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKR 611
            S+P         T+     K+      +  A + T  PAP        +  SA    K 
Sbjct: 294 KSAPTTPKEPAPTTT-----KEPAPTTPKEPAPTTTKEPAPT-------TTKSAPTTPKE 341

Query: 612 RAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGG-ERPAGE 670
            A    K+       +      K       P+E +   +  A      P P   ++PA  
Sbjct: 342 PAPTTPKKPAPTTPKEPAPTTPKEP-TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT 400

Query: 671 GQGEP---TSRPKAVTFSPDLGPV-PHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQR 726
              EP   T +  A T + +  P  P E      ++    +   +         T ++  
Sbjct: 401 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE-- 458

Query: 727 LLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQ-----SPRSP 781
              P       P P     P PTT  K A  +P    P T + P P  ++     +P+ P
Sbjct: 459 ---PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 515

Query: 782 KHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP--PEEPA 838
             T P E   AP T     P   + L       P+    +  +     E TP  PEEPA
Sbjct: 516 APTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 572



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 82/407 (20%), Positives = 127/407 (31%), Gaps = 35/407 (8%)

Query: 437 PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
           P  PAP  T + P       PT  ++                A  +    +P  P KP+ 
Sbjct: 426 PKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP 485

Query: 497 ASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPA 556
            +P  P  T+ P    PT      P P TP +P+P    E + P  P + +P        
Sbjct: 486 TTPKEPAPTT-PKEPAPTTTK--KPAPTTPKEPAPTTPKETA-PTTPKKLTPTTPEKLAP 541

Query: 557 ATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAP--PEALSSEMSELSARLEEKRRAI 614
            T  +   T+     ++L     E    +    PAP  P+A +    +  A    K  A 
Sbjct: 542 TTPEKPAPTT----PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 597

Query: 615 EAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-GGERPAGEGQG 673
              K                +   +  P    G A    +E    P P   ++PA +   
Sbjct: 598 TTPKEP------------APTTPKETAPTTPKGTAPTTLKE----PAPTTPKKPAPKELA 641

Query: 674 EPTSRPKAVTFSPDLGPVPHEGLG---EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAP 730
             T++    T      P   +G         A +       +  +     T ++     P
Sbjct: 642 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP 701

Query: 731 PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELR 790
            +       P     P  TT  K A  +P    P T + P P    +P+ P  T P    
Sbjct: 702 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP---TTPKKPAPTTPE--T 756

Query: 791 LAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
             P T  ++ P        + K      P  +      A E  P+EP
Sbjct: 757 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 803



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 45/188 (23%), Positives = 68/188 (36%), Gaps = 16/188 (8%)

Query: 437 PPRPAPARTPTQPPPEP--GDLPTI--EEALQIIHSAEPRLLPDGAADGSFYLHSPE-GP 491
           P  PAP  TP +P P    G  PT   E A        P+ L      G     S +  P
Sbjct: 669 PKEPAPT-TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 727

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEA---------SKPPA 542
           + P   +P  P+  +     +P       P P T    +P    E          S P  
Sbjct: 728 TTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 787

Query: 543 PSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSE 602
            +E +PKA+ +SP         T  A + +    A+ +       +TP    A + +M++
Sbjct: 788 SAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA-APKMTK 846

Query: 603 LSARLEEK 610
            +A   EK
Sbjct: 847 ETATTTEK 854


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 98/421 (23%), Positives = 141/421 (33%), Gaps = 43/421 (10%)

Query: 429 SVSSDSLGPPRPAPARTPTQP--PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLH 486
           ++ S    P  PAP  T + P  P EP    T E A        P    + A   +    
Sbjct: 329 TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT--KS 386

Query: 487 SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
           +P  P +P+  +P  P  T+ P    PT      P P TP +P+P     A  P  P E 
Sbjct: 387 APTTPKEPAPTTPKKPAPTT-PKEPAPTTPKE--PTPTTPKEPAPTTKEPA--PTTPKEP 441

Query: 547 SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTS--TPAPPEALSSEMSELS 604
           +P A       T  E   T+  E      K        SPT+   PAP    S+  +   
Sbjct: 442 APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKE 495

Query: 605 ARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-G 663
                 + A    K        +      K        + A    +  A      P P  
Sbjct: 496 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 555

Query: 664 GERPAGEGQGEP---TSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
            ++PA     EP   T +  A T    L P   E               L+    +    
Sbjct: 556 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE--------------KLAPTTPEKPAP 601

Query: 721 TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASP-SPARRVPATRRSPGPGPSQ--S 777
           T  ++     PE P    P      P PTT PKAA+P +P    P T + P P   +  +
Sbjct: 602 TTPEELAPTTPEEPTPTTPEE----PAPTT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPA 656

Query: 778 PRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
           P +PK T P   +    T +  P       P  ++ +P+     T ++      T P+  
Sbjct: 657 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716

Query: 838 A 838
           A
Sbjct: 717 A 717



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 79/359 (22%), Positives = 120/359 (33%), Gaps = 34/359 (9%)

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAV 551
           +KP+  +    +G +      PT      P   TP +P+P  +  A  P  P E +P   
Sbjct: 288 AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--PTTPKEPAPTTT 345

Query: 552 ASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKR 611
            S+P         T+     K+      +  A + T  PAP        +  SA    K 
Sbjct: 346 KSAPTTPKEPAPTTT-----KEPAPTTPKEPAPTTTKEPAPT-------TTKSAPTTPKE 393

Query: 612 RAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGG-ERPAGE 670
            A    K+       +      K       P+E +   +  A      P P   ++PA  
Sbjct: 394 PAPTTPKKPAPTTPKEPAPTTPKEP-TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT 452

Query: 671 GQGEP---TSRPKAVTFSPDLGPV-PHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQR 726
              EP   T +  A T + +  P  P E      ++    +   +         T ++  
Sbjct: 453 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE-- 510

Query: 727 LLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQ-----SPRSP 781
              P       P P     P PTT  K A  +P    P T + P P  ++     +P+ P
Sbjct: 511 ---PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 567

Query: 782 KHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP--PEEPA 838
             T P E   AP T     P   + L       P+    +  +     E TP  PEEPA
Sbjct: 568 APTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 624



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 82/407 (20%), Positives = 127/407 (31%), Gaps = 35/407 (8%)

Query: 437 PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
           P  PAP  T + P       PT  ++                A  +    +P  P KP+ 
Sbjct: 478 PKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP 537

Query: 497 ASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPA 556
            +P  P  T+ P    PT      P P TP +P+P    E + P  P + +P        
Sbjct: 538 TTPKEPAPTT-PKEPAPTTTK--KPAPTTPKEPAPTTPKETA-PTTPKKLTPTTPEKLAP 593

Query: 557 ATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAP--PEALSSEMSELSARLEEKRRAI 614
            T  +   T+     ++L     E    +    PAP  P+A +    +  A    K  A 
Sbjct: 594 TTPEKPAPTT----PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 649

Query: 615 EAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-GGERPAGEGQG 673
              K                +   +  P    G A    +E    P P   ++PA +   
Sbjct: 650 TTPKEP------------APTTPKETAPTTPKGTAPTTLKE----PAPTTPKKPAPKELA 693

Query: 674 EPTSRPKAVTFSPDLGPVPHEGLG---EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAP 730
             T++    T      P   +G         A +       +  +     T ++     P
Sbjct: 694 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP 753

Query: 731 PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELR 790
            +       P     P  TT  K A  +P    P T + P P    +P+ P  T P    
Sbjct: 754 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP---TTPKKPAPTTPE--T 808

Query: 791 LAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
             P T  ++ P        + K      P  +      A E  P+EP
Sbjct: 809 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 855



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 45/188 (23%), Positives = 68/188 (36%), Gaps = 16/188 (8%)

Query: 437 PPRPAPARTPTQPPPEP--GDLPTI--EEALQIIHSAEPRLLPDGAADGSFYLHSPE-GP 491
           P  PAP  TP +P P    G  PT   E A        P+ L      G     S +  P
Sbjct: 721 PKEPAPT-TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 779

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEA---------SKPPA 542
           + P   +P  P+  +     +P       P P T    +P    E          S P  
Sbjct: 780 TTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 839

Query: 543 PSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSE 602
            +E +PKA+ +SP         T  A + +    A+ +       +TP    A + +M++
Sbjct: 840 SAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA-APKMTK 898

Query: 603 LSARLEEK 610
            +A   EK
Sbjct: 899 ETATTTEK 906


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 98/421 (23%), Positives = 141/421 (33%), Gaps = 43/421 (10%)

Query: 429 SVSSDSLGPPRPAPARTPTQP--PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLH 486
           ++ S    P  PAP  T + P  P EP    T E A        P    + A   +    
Sbjct: 370 TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT--KS 427

Query: 487 SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
           +P  P +P+  +P  P  T+ P    PT      P P TP +P+P     A  P  P E 
Sbjct: 428 APTTPKEPAPTTPKKPAPTT-PKEPAPTTPKE--PTPTTPKEPAPTTKEPA--PTTPKEP 482

Query: 547 SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTS--TPAPPEALSSEMSELS 604
           +P A       T  E   T+  E      K        SPT+   PAP    S+  +   
Sbjct: 483 APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKE 536

Query: 605 ARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-G 663
                 + A    K        +      K        + A    +  A      P P  
Sbjct: 537 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 596

Query: 664 GERPAGEGQGEP---TSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRL 720
            ++PA     EP   T +  A T    L P   E               L+    +    
Sbjct: 597 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE--------------KLAPTTPEKPAP 642

Query: 721 TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASP-SPARRVPATRRSPGPGPSQ--S 777
           T  ++     PE P    P      P PTT PKAA+P +P    P T + P P   +  +
Sbjct: 643 TTPEELAPTTPEEPTPTTPEE----PAPTT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPA 697

Query: 778 PRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
           P +PK T P   +    T +  P       P  ++ +P+     T ++      T P+  
Sbjct: 698 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757

Query: 838 A 838
           A
Sbjct: 758 A 758



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 79/359 (22%), Positives = 120/359 (33%), Gaps = 34/359 (9%)

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAV 551
           +KP+  +    +G +      PT      P   TP +P+P  +  A  P  P E +P   
Sbjct: 329 AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--PTTPKEPAPTTT 386

Query: 552 ASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKR 611
            S+P         T+     K+      +  A + T  PAP        +  SA    K 
Sbjct: 387 KSAPTTPKEPAPTTT-----KEPAPTTPKEPAPTTTKEPAPT-------TTKSAPTTPKE 434

Query: 612 RAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGG-ERPAGE 670
            A    K+       +      K       P+E +   +  A      P P   ++PA  
Sbjct: 435 PAPTTPKKPAPTTPKEPAPTTPKEP-TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT 493

Query: 671 GQGEP---TSRPKAVTFSPDLGPV-PHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQR 726
              EP   T +  A T + +  P  P E      ++    +   +         T ++  
Sbjct: 494 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE-- 551

Query: 727 LLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQ-----SPRSP 781
              P       P P     P PTT  K A  +P    P T + P P  ++     +P+ P
Sbjct: 552 ---PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 608

Query: 782 KHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP--PEEPA 838
             T P E   AP T     P   + L       P+    +  +     E TP  PEEPA
Sbjct: 609 APTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 665



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 82/407 (20%), Positives = 127/407 (31%), Gaps = 35/407 (8%)

Query: 437 PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
           P  PAP  T + P       PT  ++                A  +    +P  P KP+ 
Sbjct: 519 PKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP 578

Query: 497 ASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPA 556
            +P  P  T+ P    PT      P P TP +P+P    E + P  P + +P        
Sbjct: 579 TTPKEPAPTT-PKEPAPTTTK--KPAPTTPKEPAPTTPKETA-PTTPKKLTPTTPEKLAP 634

Query: 557 ATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAP--PEALSSEMSELSARLEEKRRAI 614
            T  +   T+     ++L     E    +    PAP  P+A +    +  A    K  A 
Sbjct: 635 TTPEKPAPTT----PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 690

Query: 615 EAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVP-GGERPAGEGQG 673
              K                +   +  P    G A    +E    P P   ++PA +   
Sbjct: 691 TTPKEP------------APTTPKETAPTTPKGTAPTTLKE----PAPTTPKKPAPKELA 734

Query: 674 EPTSRPKAVTFSPDLGPVPHEGLG---EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAP 730
             T++    T      P   +G         A +       +  +     T ++     P
Sbjct: 735 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP 794

Query: 731 PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELR 790
            +       P     P  TT  K A  +P    P T + P P    +P+ P  T P    
Sbjct: 795 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP---TTPKKPAPTTPE--T 849

Query: 791 LAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEP 837
             P T  ++ P        + K      P  +      A E  P+EP
Sbjct: 850 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 896



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 45/188 (23%), Positives = 68/188 (36%), Gaps = 16/188 (8%)

Query: 437 PPRPAPARTPTQPPPEP--GDLPTI--EEALQIIHSAEPRLLPDGAADGSFYLHSPE-GP 491
           P  PAP  TP +P P    G  PT   E A        P+ L      G     S +  P
Sbjct: 762 PKEPAPT-TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 820

Query: 492 SKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEA---------SKPPA 542
           + P   +P  P+  +     +P       P P T    +P    E          S P  
Sbjct: 821 TTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 880

Query: 543 PSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSE 602
            +E +PKA+ +SP         T  A + +    A+ +       +TP    A + +M++
Sbjct: 881 SAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA-APKMTK 939

Query: 603 LSARLEEK 610
            +A   EK
Sbjct: 940 ETATTTEK 947


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 141/562 (25%), Positives = 189/562 (33%), Gaps = 101/562 (17%)

Query: 488 PEGPSKPSLASPYL-PEGTSKPLSDRPTKA--PVYMPHPETPSKPSPCLVGEASKPPAPS 544
           P  P KP L  P+  P G   P  D P +   P   P PE   +       ++S   + +
Sbjct: 405 PPAP-KPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLA 463

Query: 545 EGSPKAVASSPAATNSEVKMTSFAERKKQL----------VKAEAEAGAGSPTSTPAPPE 594
               +           E +  + AE+ K+L          +KAE  A   +P STPAPP 
Sbjct: 464 VERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAP-STPAPPP 522

Query: 595 ALSSEMSELSA-----------RLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPR 643
           A+  E+    A             EE  +A  AQ      + A      G  +       
Sbjct: 523 AVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSST--- 579

Query: 644 EASGEAEAEAEE----ADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEY 699
            +SG  EA   E    +  GP P  E P       P   PK     P   P P +GLG Y
Sbjct: 580 -SSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQP-PSQGLG-Y 636

Query: 700 NRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPP------PAAWVIPGPTTGPK 753
            +    L       Q++  +L  QQQ+        GSAPP      P   V  G    P+
Sbjct: 637 PKYQKSLPPRFQRQQQE--QLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQ 694

Query: 754 AASPSPARRVPATRRSPGPGPSQS--PR---SPKHTRPAELRLAPLTRVLTP-PHDVDSL 807
           A  P P    P     P P P  +  PR    P +  P  L+  P      P  H    +
Sbjct: 695 APPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLV 754

Query: 808 PHLRKFS--PSQVPVQTRSSILLAEE-TPPEEP------------AARPGLIEIPLGSLA 852
           P  R  S   S  P    +  +L E  TPP +P             A P  +  PL   A
Sbjct: 755 PRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAA 814

Query: 853 DPAAEDEGDGSPAGAEDSLEEEASS------EGEPRVGLGFFYKDEDKP--------EDE 898
           D   +D+G  S            +S       G P   +  F  +E  P         DE
Sbjct: 815 D--EDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDE 872

Query: 899 MAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEA-PGPAPLVSAVPMAT 957
           +A                   + Q    +KE  +EE A+L   EA   PA  V +     
Sbjct: 873 VA-------------------KIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGP 913

Query: 958 PAPAARAPAEEEVGPRKGDFTR 979
           P P   +  E   GPR G   R
Sbjct: 914 PPPRRESRTETRWGPRPGSSRR 935



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 170/766 (22%), Positives = 252/766 (32%), Gaps = 143/766 (18%)

Query: 395  RQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSS-DSLGPPRPAPARTPTQPP-PE 452
            R L+ PL QA       G+ S+   V   P  L S       G P P  +R P + P P 
Sbjct: 804  RPLTSPLRQAADEDDK-GMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPR 862

Query: 453  PGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSD- 511
            P   P   + +  I +  P+  P    + +  L  PE   KP+       +G   P  + 
Sbjct: 863  PLPWPPGSDEVAKIQTPPPKKEPP--KEETAQLTGPEAGRKPARGVGSGGQGPPPPRRES 920

Query: 512  --------RPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVK 563
                    RP  +   +P PE P  P P   G   KPP P++     V   P     +  
Sbjct: 921  RTETRWGPRPGSSRRGIP-PEEPGAP-PRRAGPIKKPPPPTK-----VEELPPKPLEQGD 973

Query: 564  MTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEA 623
             T    +   L   + + G    T    PP    S    L      +R    + + R   
Sbjct: 974  ETPKPPKPDPLKITKGKLGGPKET----PPNGNLSPAPRLRRDYSYERVGPTSCRGRGRG 1029

Query: 624  -IFAKHRQRLGK--SAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPK 680
              FA+ R   G         + RE     E   ++   G   G   P    +G   S  +
Sbjct: 1030 EYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAP-RGRTASETR 1088

Query: 681  AVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPP 740
            +     +  P      G    + +  S    S   D +  T ++  L   P AP   PPP
Sbjct: 1089 SEGSEYEEIPKRRRQRGSETGSETHESDLAPS---DKEAPTPKEGTLTQVPLAP---PPP 1142

Query: 741  AAWVIPGPTT----GPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTR 796
             A   P P      G +  +P   R VP+ RR  G G     R P    P          
Sbjct: 1143 GAPPSPAPARFTARGGRVFTP---RGVPS-RRGRGGG-----RPPPQVCPG--------- 1184

Query: 797  VLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAA 856
              +PP         +  +P + P            T P  P+  P   ++  G L+  A 
Sbjct: 1185 -WSPP--------AKSLAPKKPP------------TGPLPPSKEPLKEKLIPGPLSPVAR 1223

Query: 857  EDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEE 916
                 GS  G ED                            E  ++R     +QQ +   
Sbjct: 1224 GGSNGGSNVGMEDG---------------------------ERPRRRRHGRAQQQDKPPR 1256

Query: 917  ARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGD 976
             RR KQ +E        + +      APGP   ++ V +A PAP   A    ++  +  D
Sbjct: 1257 FRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTVTVA-PAPRRAAAKSPDLSNQNSD 1315

Query: 977  FTRQEYERRAQLKLMDDLDK---------VLRPRAAGSGGPGRGGRRATRPRSGCCDDSA 1027
               +E+E  ++        +         +L P+A G+ G G GG             SA
Sbjct: 1316 QANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGG--------AVPGISA 1367

Query: 1028 LARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNL---GVKRPTSRAPS------PSGL 1078
            ++R        S+ +K  S+ + S      E  N     G K  +S + S      P G 
Sbjct: 1368 MSRGDL-----SQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGR 1422

Query: 1079 MSPSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFI 1124
              P R     +R W +  N S P   PE   P L   P   S+  +
Sbjct: 1423 TGPGR---GDKRSWPSPKNRSRP---PEERPPGLPLPPPPPSSSAV 1462



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 88/389 (22%), Positives = 132/389 (33%), Gaps = 55/389 (14%)

Query: 429 SVSSDSLGPPRPAPARTPTQP--PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLH 486
           +V  +   PP P PA  PT    P EP   P  +       +A P L+  G +  S    
Sbjct: 523 AVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSG 582

Query: 487 SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
           S E       ASP  P+  SK   + P + P     P    +P    +G   +PP+   G
Sbjct: 583 SFE-------ASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLG 635

Query: 547 SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTST-PAPPEALSSEMSELSA 605
            PK   S P     + +     ++++Q    + + G+  PT   P+PP+ ++        
Sbjct: 636 YPKYQKSLPPRFQRQ-QQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVT-------- 686

Query: 606 RLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFL--------------QVQPREASGEAEA 651
                  A+ A +       A +   LG+   +               V PR   G    
Sbjct: 687 -----LGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPL 741

Query: 652 EAEEA---DSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHE----GLGEYNRAVS 704
           +        SG VP     +G    EP  R  A     + G  P +     +G+   A  
Sbjct: 742 DFYPPGVHPSGLVPRERSDSGGSSSEPFDR-HAPAMLRERGTPPVDPKLAWVGDVFTATP 800

Query: 705 KLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVP 764
                L+S  R      D+  R   PP      PPP  ++   P      A   P  R P
Sbjct: 801 AEPRPLTSPLRQAADEDDKGMRSETPP-----VPPPPPYLASYPGFPENGAPGPPISRFP 855

Query: 765 ATRRSPGPGPSQSPRSPKHTRPAELRLAP 793
                  PGP   P  P     A+++  P
Sbjct: 856 LEE----PGPRPLPWPPGSDEVAKIQTPP 880



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 100/401 (24%), Positives = 140/401 (34%), Gaps = 86/401 (21%)

Query: 487  SPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEG 546
            SP+G  K +   P    G S PL+  P + P   P  E P +P          PPAP +G
Sbjct: 1671 SPDGGLKGAAEGPPKRPGGSSPLNAVPCEGP---PGSEPPRRP----------PPAPHDG 1717

Query: 547  SPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSAR 606
              K +          +        + Q      E G   P+  P PP    +   +   R
Sbjct: 1718 DRKELPREQPLPPGPI-----GTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLR 1772

Query: 607  LEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSG-----PV 661
            L     +++A+K     + A   + +  S   ++ P  A+  AE +++  DSG     P 
Sbjct: 1773 L-VVGDSLKAEKE----LTASVTEAIPVSRDWELLP-SAAASAEPQSKNLDSGHCVPEPS 1826

Query: 662  PGGERPAGE---GQGEPTS------------RPKAVTF---SPDLGPVPHEGLGEYNRAV 703
              G+R   E   G   P+S             P +  F   +P L P   + L       
Sbjct: 1827 SSGQRLYPEVFYGSAGPSSSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPL-YLPPGP 1885

Query: 704  SKLSAALSSLQRDMQRL---TDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPA 760
            +  SA LS L    Q L   T Q   L   P      PPP+    P       A  PSP 
Sbjct: 1886 APPSALLSGLALKGQFLDFSTMQATELGKLPAGGVLYPPPSFLYSP-------AFCPSP- 1937

Query: 761  RRVPATR----RSPGPGPS---QSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKF 813
              +P T     R   P PS    +P  P          AP  ++L P  D          
Sbjct: 1938 --LPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVD---------- 1985

Query: 814  SPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADP 854
              SQ+PV    S+      PP  P A P L  +P+G    P
Sbjct: 1986 --SQLPVVNFGSL------PPAPPPAPPPLSLLPVGPALQP 2018



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 72/301 (23%), Positives = 102/301 (33%), Gaps = 54/301 (17%)

Query: 569  ERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKH 628
            ER+     +E +     P S P P EAL++                         +    
Sbjct: 1263 ERENAARGSEGKPSLTLPASAPGPEEALTT-----------------------VTVAPAP 1299

Query: 629  RQRLGKSAFLQVQ-PREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPD 687
            R+   KS  L  Q   +A+ E E  +E +D      G++ A          P  V  +P 
Sbjct: 1300 RRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEA----------PPPVLLTPK 1349

Query: 688  LGPVPHEGLGEYNRAVSKLSAA-LSSLQRDMQRLTDQQQR--LLAPPEAPGSAPPPAAWV 744
                P  G G     +S +S   LS   +D+ + +   QR  +      PG         
Sbjct: 1350 AVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPG--------- 1400

Query: 745  IPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKH-TRPAELRLAPLTRVLTPPHD 803
             PG   G   +S       P  R  PG G  +S  SPK+ +RP E R   L     PP  
Sbjct: 1401 -PGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSS 1459

Query: 804  -----VDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAED 858
                 +D + H       Q   Q  SS   +   P   P  +PGL + P G    P    
Sbjct: 1460 SAVFRLDQVIHSNPAGIQQALAQL-SSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRY 1518

Query: 859  E 859
            E
Sbjct: 1519 E 1519



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 39/145 (26%), Positives = 56/145 (38%), Gaps = 16/145 (11%)

Query: 831 ETPPEEPAARPGLIEI---PLGSLADPAAEDEGDGSPAGA-----EDSLEEEASSEGEPR 882
           ET P  PA +P L      P G+   P    +  G P        ED    +   +    
Sbjct: 400 ETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSE 459

Query: 883 VGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRR-KQWQEVEKEQRREEAARLAQE 941
           + L        + E+E   +     ER+   AE+ +R  +++   +K  + E AA  A  
Sbjct: 460 ISLAVERARRRREEEERRMQE----ERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAP 515

Query: 942 EAPGPAPLVSAVPMATPAPAARAPA 966
             P P P   AVP   PAP A  PA
Sbjct: 516 STPAPPP---AVPKELPAPPAPPPA 537



 Score = 34.7 bits (78), Expect = 0.58
 Identities = 26/65 (40%), Positives = 31/65 (47%), Gaps = 10/65 (15%)

Query: 731  PEAPGSAPPPAAWVIPGPTTGPK--AASPSPARRVPATRRSPGPG---PSQSPRSPKHTR 785
            P AP  APPP + +  GP   P   A  P PA   PATR  P P    P+   R+  H  
Sbjct: 1997 PPAPPPAPPPLSLLPVGPALQPPSLAVRPPPA---PATRVLPSPARPFPASLGRAELH-- 2051

Query: 786  PAELR 790
            P EL+
Sbjct: 2052 PVELK 2056



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 85/370 (22%), Positives = 113/370 (30%), Gaps = 77/370 (20%)

Query: 439  RPAPARTPTQP-PPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLA 497
            RP   R P  P PP P     +    Q+IHS  P  +    A  S    S   P      
Sbjct: 1441 RPPEERPPGLPLPPPPPSSSAVFRLDQVIHS-NPAGIQQALAQLSSRQGSVTAPGGHPRH 1499

Query: 498  SPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKP----PAPS-EGSPKAVA 552
             P LP+    P            P P T  +P     G +S P    P P   G      
Sbjct: 1500 KPGLPQAPQGP-----------SPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPR 1548

Query: 553  SSPAATNSEVKMTSFAERKKQLVKAE------AEAGAGSPTSTPAP-PEALSSEMSELSA 605
             S   +    K      RK +L++ E      +    GS    P P  E+  +    L+ 
Sbjct: 1549 DSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTP 1608

Query: 606  RLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREA----SGEAEAEAEEADSGPV 661
             +  +     ++K    +      + L  S F  V   E     SG   +   +  SGP 
Sbjct: 1609 HIWNRLHTATSRKSYRPSSMEPWMEPL--SPFEDVAGTEMSQSDSGVDLSGDSQVSSGPC 1666

Query: 662  PGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLT 721
                 P G  +G     PK    S  L  VP EG                          
Sbjct: 1667 SQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEG-------------------------- 1700

Query: 722  DQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGP-GPSQSPRS 780
                    P   P   PPPA      P  G +   P   R  P     PGP G  +S R+
Sbjct: 1701 -------PPGSEPPRRPPPA------PHDGDRKELP---REQPL---PPGPIGTERSQRT 1741

Query: 781  PKHTRPAELR 790
             + T P  +R
Sbjct: 1742 DRGTEPGPIR 1751



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 78/372 (20%), Positives = 116/372 (31%), Gaps = 57/372 (15%)

Query: 490  GPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGS-- 547
            GP +    S   P+  S+P  +RP            P  P P        PP PS  +  
Sbjct: 1424 GPGRGDKRSWPSPKNRSRPPEERP------------PGLPLP--------PPPPSSSAVF 1463

Query: 548  --PKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSA 605
               + + S+PA     +   S  +           A  G P   P  P+A          
Sbjct: 1464 RLDQVIHSNPAGIQQALAQLSSRQ-------GSVTAPGGHPRHKPGLPQAPQGPSPRPPT 1516

Query: 606  RLEEKR--------RAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEAD 657
            R E +R           E     +  +    R   G S F   +      + E   EE+ 
Sbjct: 1517 RYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESL 1576

Query: 658  SGPVPG---GERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQ 714
              P      G +P G G    +        +P +           + A S+ S   SS++
Sbjct: 1577 PPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHI-------WNRLHTATSRKSYRPSSME 1629

Query: 715  RDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGP 774
              M+ L+  +   +A  E   S            ++GP +   SP   +      P   P
Sbjct: 1630 PWMEPLSPFED--VAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRP 1687

Query: 775  SQSPRSPKHTRPAE--LRLAPLTRVLTPPHDVD--SLPHLRKFSPSQVPVQTRSSILLAE 830
              S  SP +  P E      P  R    PHD D   LP  +   P  +  +         
Sbjct: 1688 GGS--SPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGT 1745

Query: 831  ETPPEEPAARPG 842
            E  P  P+ RPG
Sbjct: 1746 EPGPIRPSHRPG 1757


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 149/621 (23%), Positives = 212/621 (34%), Gaps = 110/621 (17%)

Query: 407  FSTPFGLDSD-VDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQI 465
            +S  +GL S  VD +   P  + +V+      P P    +  Q  P P        A  +
Sbjct: 1851 YSPDYGLPSPKVDALHCPPAAVVTVT------PSPEGVFSSLQAKPSPSP-----RAELL 1899

Query: 466  IHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPET 525
            + S E  L PD          +   P +PS   P L EG   P S   T+ PV   HP  
Sbjct: 1900 VPSLEGALPPDLDTSEDQQATAAIIPPEPSYLEP-LDEG---PFSAVITEEPVEWAHPSE 1955

Query: 526  PSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVK---AEAEAG 582
             +  S  + G +  P +   GS   +  SP       K    A+          + +EA 
Sbjct: 1956 QALASSLIGGTSENPVSWPVGS-DLLLKSPQRFPESPKRFCPADPLHSAAPGPFSASEAP 2014

Query: 583  AGSPTSTPAP---------PEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLG 633
              +P ++PAP          E +   +  + A +     A  A    +E+ F+  +    
Sbjct: 2015 YPAPPASPAPYALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSL-- 2072

Query: 634  KSAFLQVQPREASGEAEAEAE---EADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGP 690
              A L V P  A   A A+ E     ++  + G    +  GQ EP   P A  F+   GP
Sbjct: 2073 PEAPLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPV--PWADAFA---GP 2127

Query: 691  VPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQ----QRLLAPPEAPGSAPPPAAWVIP 746
                 LG +         +L  L    +   D +    +  LAPPE     PP A  VI 
Sbjct: 2128 EDDLDLGPF---------SLPELPLQTKDAADGEAEPVEESLAPPE---EMPPGAPGVIN 2175

Query: 747  GPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDS 806
            G       A   PA           P    S R P    P       L   L    + ++
Sbjct: 2176 GGDVSTVVAEEPPAL----------PPDQASTRLPAELEPEPSGEPKLDVALEAAVEAET 2225

Query: 807  LPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEG-DGSPA 865
            +P  R        V+           PPE+          PLGS  D  AE EG   +  
Sbjct: 2226 VPEERARGDPDSSVE-------PAPVPPEQR---------PLGS-GDQGAEAEGPPAASL 2268

Query: 866  GAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLER------QQRRAE---- 915
             A D       ++ +   G G        PED+    RA+          Q   AE    
Sbjct: 2269 CAPDGPAPNTVAQAQAADGAG--------PEDDTEASRAAAPAEGPPGGIQPEAAEPKPT 2320

Query: 916  -EARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAE------- 967
             EA +  + +E+ +   R  A  LA +   GP P        TPAP  RA A        
Sbjct: 2321 AEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPPSEKEC-APTPAPVTRAKARGSEDDDA 2379

Query: 968  EEVGPRKGDFTRQEYERRAQL 988
            +   PRK  F R   + + QL
Sbjct: 2380 QAQHPRKRRFQRSTQQLQQQL 2400



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 55/225 (24%), Positives = 88/225 (39%), Gaps = 38/225 (16%)

Query: 437  PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
            PP  A  R P +  PEP   P ++ AL+   + E   +P+  A G      P+   +P+ 
Sbjct: 2191 PPDQASTRLPAELEPEPSGEPKLDVALEA--AVEAETVPEERARG-----DPDSSVEPAP 2243

Query: 497  ASPY---LPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVG---------EASKPPAPS 544
              P    L  G     ++ P  A +  P    P+  +              EAS+  AP+
Sbjct: 2244 VPPEQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPA 2303

Query: 545  EGSPKAV---ASSPAATNSEVKMTSFAERKKQLVKAEAEAGA-----GSPTS------TP 590
            EG P  +   A+ P  T    K     E  +++ +  A+  A     G P S      TP
Sbjct: 2304 EGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPPSEKECAPTP 2363

Query: 591  APPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKS 635
            AP     +  SE     ++  +A   +KRR +    + +Q+L  S
Sbjct: 2364 APVTRAKARGSE-----DDDAQAQHPRKRRFQRSTQQLQQQLNTS 2403


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 134/527 (25%), Positives = 168/527 (31%), Gaps = 109/527 (20%)

Query: 333 ASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLR-GSTGSLKSSPSMSHMEALGK 391
           AS RG  A P +N S           P+ S G      R G  G      S     A GK
Sbjct: 87  ASGRGERAPPAKNTSPG---------PVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 137

Query: 392 AWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRS--VSSDSLGPPRPAPARTP--- 446
           A        LS      T     S        P + R    +   +G PRPAP+  P   
Sbjct: 138 ATEAPKRSALSAGARRDT-----SGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 192

Query: 447 ----------------TQPPPEPGDLPTIEEALQ------IIHSAEPRLLPDGAADGSFY 484
                           T+P P     P+    LQ      +  SA P   P  A  G   
Sbjct: 193 TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP--ARSGPSA 250

Query: 485 LHSPEGPSKPSLASPYLPEGTSKPLSDRPTK--APVYMPHPETP-SKPSPCLVGEASKPP 541
             +P  P+ PS   P   +    P    P K  AP   P   +P + PSP      S PP
Sbjct: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP------SAPP 304

Query: 542 APSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAP--PEAL--- 596
           +PS         SP AT      TS      Q   +   +   SP +TP P  P AL   
Sbjct: 305 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 364

Query: 597 ----------SSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREAS 646
                     S  +S L+    +   A+      ++A F+               P +A 
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAVHL--LQAPFSPPPS----------PPVQAP 412

Query: 647 GEAEAEAEEADSGPVPGGERP--AGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVS 704
               A    + S   P    P  A      P S P +   SP   P P         A  
Sbjct: 413 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ---APPPLAAP 469

Query: 705 KLSAALSSLQRDMQRLTDQQQRLLAPPEA-PGSAP-------PPAAWVIPGPTTGPKAAS 756
            L  A    Q      T   Q L +PP + PG AP       P +    P P   P  A+
Sbjct: 470 PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529

Query: 757 P----------SPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAP 793
           P          SP  + P  RR P PGP  S   P+ T    L LAP
Sbjct: 530 PLLQVPPSPPASPTLQAP--RRPPTPGPDTSVSGPRLT----LALAP 570



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 177/782 (22%), Positives = 249/782 (31%), Gaps = 146/782 (18%)

Query: 437  PPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSL 496
            P   AP     +PP  P   P +  A   +  A   +     A+ +  +    G + P  
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG---GATIPES 73

Query: 497  ASPYLPEGTSKP-LSDRPTKAPVYMPHPETPSKPSPCLV-GEASKPPAPSEGSPKAVASS 554
            A    P  TS+P  S R  +AP     P   + P P    G AS    P     K +  S
Sbjct: 74   APRAGPTRTSRPPASGRGERAP-----PAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128

Query: 555  PAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARL------- 607
               T +  K T   +R      A  +    +P  TP+P  A  S  +     L       
Sbjct: 129  AEETVARGKATEAPKRSALSAGARRDTSGPTP-GTPSPAMARRSRAAGTEVGLPRPAPSA 187

Query: 608  ------EEKRRAIEAQKRR--IEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSG 659
                  E  R+++ +       E   A  R+        +   R  S  A   +  A SG
Sbjct: 188  RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 247

Query: 660  PVPGG--ERPAGEGQGEPTS----RPKAVT-----FSPDLGPVPHEGLGEYNRAVSKLSA 708
            P   G    PA   Q +P      RP  VT      +P LGP+    L   + +     +
Sbjct: 248  PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS 307

Query: 709  ALSSLQR----------------DMQRLTDQQQRLLAPPEAPGSAPPPAA---------W 743
            A  SLQ                     L      L +PP +P + PPP A          
Sbjct: 308  APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 367

Query: 744  VIPGPTTGPKA---ASPSP------ARRVPATRRSPGPGPS-QSPRSPKHTRPAELRLAP 793
              P P   P     A+PSP      A  +     SP P P  Q+P SP  + P      P
Sbjct: 368  APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 427

Query: 794  LTR----VLTPPHDV-DSLPHLRKFSPS-----QVPVQTRSSILLAEETPPEEPAARPGL 843
             ++    +  PP  V  S P     SPS     Q P    +  L   + PP+ P   P L
Sbjct: 428  PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP---PAL 484

Query: 844  IEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKR 903
               PL +L  P A   G  +P     SL     +   P+            P    A   
Sbjct: 485  ATPPLQALPSPPASFPGQ-APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 543

Query: 904  ASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAAR 963
                 R      +                    RL    APGP           P P +R
Sbjct: 544  LQAPRRPPTPGPDT--------------SVSGPRLTLALAPGP-----------PPPPSR 578

Query: 964  APAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRP---RS 1020
            +P+    GP     +        +L+  D              GP  GG  A+ P     
Sbjct: 579  SPSSTLSGPDLAGHSSSATSTPEELRGYD-------------SGP-EGGAAASPPPDAEL 624

Query: 1021 GCCDDSALARSPA-----RGLLGSRL---SKIYSQSTLSLSTVANEAHNNLGVKRPTSRA 1072
              C  +A +R PA     RG  G+ L         S   L T+          + P S  
Sbjct: 625  AACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYE-------TEGPESAT 677

Query: 1073 PSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHC 1132
            P+P G + P   PG+       G+ A + +  P+    RL + P       ++ + LS  
Sbjct: 678  PAP-GALDPGPSPGTSGGKAAAGAGAGASSRSPKQA--RLGELPLGALQASVVQHLLSRT 734

Query: 1133 CL 1134
             L
Sbjct: 735  LL 736



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 161/686 (23%), Positives = 224/686 (32%), Gaps = 105/686 (15%)

Query: 97  TPPNPSALLALLARR-GTVPALPERPVREADLRHQPILMGAHLAVIDALMAAFAFEWTKT 155
           TP  PS  +A  +R  GT   LP RP   A  R +P   G   +V      + A E + T
Sbjct: 159 TPGTPSPAMARRSRAAGTEVGLP-RPAPSA--RPRPPTEGPRKSV------SSASEHSTT 209

Query: 156 LPGPLALT------SLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIR 209
            P P A         L+      + ++   L        + R +P APA  + P    ++
Sbjct: 210 EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQ 269

Query: 210 -YRKDRVVARRAPCFPTVTSLQD--LASGAALAATIHCYCPQLLRLEEVCLKDPMSVADS 266
             R  +V   R    P +  L    LA+ +  A       P L  L       P     S
Sbjct: 270 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTS 329

Query: 267 LYN--LQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQV 324
           L +  LQ    F  S      PLS    L  PPP +    + L  L              
Sbjct: 330 LGSPTLQATHSFLPSP-----PLSP---LATPPP-QAPPALALPPL-------------- 366

Query: 325 KDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMS 384
              P    ASP  +  + P   + ++  V   + P      P SP   +  S  +SP +S
Sbjct: 367 -QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF---SPPPSPPVQAPFSPPASPPVS 422

Query: 385 HMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPAR 444
                        + P SQA        L          P+   +       PP  AP  
Sbjct: 423 PS-----------ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 471

Query: 445 TPTQPPPE-PGDLPTIE-EALQIIHSAEPRLLP--DGAADGSFYLHSPEGPSKPSLASPY 500
              +PPP+ P  L T   +AL    ++ P   P    A+     L +P   + P LA+P 
Sbjct: 472 QLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL 531

Query: 501 L---PEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAA 557
           L   P   + P    P + P   P P+T        +  A  PP P   SP +  S P  
Sbjct: 532 LQVPPSPPASPTLQAPRRPPT--PGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL 589

Query: 558 TNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQ 617
                  TS  E  +          A SP     PP+A   E++        +  A    
Sbjct: 590 AGHSSSATSTPEELRGYDSGPEGGAAASP-----PPDA---ELAACHPAAWSRGPAPPLA 641

Query: 618 KRRIEAIFAKHRQRLGKSA---FLQVQPREASGEAEAEAEEADSGPVP---GGERPAGEG 671
            R             G  +      +   E    A       D GP P   GG+  AG G
Sbjct: 642 FRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAG 701

Query: 672 QGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPP 731
            G  +  PK       LG +P                 L +LQ  + +    +  LLA  
Sbjct: 702 AGASSRSPKQAR----LGELP-----------------LGALQASVVQHLLSRTLLLAAA 740

Query: 732 E--APGSAPPPAAWVIPGPTTGPKAA 755
           E  A GS   P      G T G +AA
Sbjct: 741 EGAAGGSGGGPGGAEGGGVTGGARAA 766



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 88/365 (24%), Positives = 126/365 (34%), Gaps = 72/365 (19%)

Query: 525 TPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAG 584
           TP+  +P L+    +PP    GSP+     P  T + +++   A    +   AE   G G
Sbjct: 16  TPAARAPGLL--TPRPP----GSPRP---PPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 585 SPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQR-------LGKSAF 637
             T   + P A  +  S   A      RA  A+      + +  R         LG+   
Sbjct: 67  GATIPESAPRAGPTRTSRPPAS-GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 125

Query: 638 -LQVQPREASGEA---------EAEAEEADSGPVPGGERPA--------GEGQGEPTSRP 679
            +  +   A G+A          A A    SGP PG   PA        G   G P   P
Sbjct: 126 RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 185

Query: 680 KAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPP 739
            A    P  GP          ++VS  S             T+        P A G    
Sbjct: 186 SARPRPPTEGP---------RKSVSSASE---------HSTTEPSPAARRRPSAGGGLQR 227

Query: 740 PAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLT 799
           PA+  +    T       SPAR  P+ R +P     ++P  P   +P  L+     +V T
Sbjct: 228 PASRSLSSSAT----PLSSPARSGPSARGTP-----RAPAHPSQPKPKGLQALRPPQV-T 277

Query: 800 PPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDE 859
           PP   D+ P L   S S +   + S+        P  P+A P L  +P      P+    
Sbjct: 278 PPRK-DAAPALGPLSSSPLATPSPSA--------PPSPSAPPSLQTLPSPPATPPSQATT 328

Query: 860 GDGSP 864
             GSP
Sbjct: 329 SLGSP 333


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 107/465 (23%), Positives = 176/465 (37%), Gaps = 63/465 (13%)

Query: 536 EASKPPAPSEGSPKAVASSP----AATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA 591
           + + P A     P++ ++SP    + T S  +     ER +   + +  AG GSP     
Sbjct: 350 DRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGE---RRKPNAG-GSPAPVRR 405

Query: 592 PPEALSSEMSELS--ARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEA 649
            PEA   +  E     R  EK ++  A++R +     K RQ L  S   ++    AS E 
Sbjct: 406 RPEASPVQKKEKKDKERENEKEKSALARERSL-----KKRQSLPASPRARLSASTAS-EL 459

Query: 650 EAEAEEADSGPVPGGERPA------GEGQGEPTS--RPKAVTFSPDLGPVPHEGLGEYNR 701
             +++   S P     RPA      G G   P     P+  T SP       +G      
Sbjct: 460 SPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASP-------KGRVRRKE 512

Query: 702 AVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPAR 761
              +  +A     +   +     ++  A P +P  +P P+    P     P A +P+ A 
Sbjct: 513 EAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAA 572

Query: 762 RVPATRRSPGPGPSQSPRSPKH-TRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPV 820
            + +    P P P  +P  P   T   E      TR+L            R+ +  Q   
Sbjct: 573 VLTSP---PAPAPPVTPSKPMAGTTDRE----EATRLLAEK---------RRQAREQRER 616

Query: 821 QTRSSILLAEETPP--EEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSE 878
           + +   L AE      EE  AR           A+  AE E +      E    E+A +E
Sbjct: 617 EEQERRLQAERDKRMREEQLARE----------AEARAEREAEARRR-EEQEAREKAQAE 665

Query: 879 GEPRVGLGFFYKDEDKPEDEMAQKRASLLER--QQRRAEEARRRKQWQEVEKEQRREEAA 936
            E +  L    ++ +    E A+++    E+  QQ+  E   RRK+ +E+ K  R+ E +
Sbjct: 666 QEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVS 725

Query: 937 RLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQE 981
              Q++    A    + P    A  AR+P  ++   +K +   QE
Sbjct: 726 ETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 135/580 (23%), Positives = 200/580 (34%), Gaps = 88/580 (15%)

Query: 438 PRPAPARTPTQPPPE-----PGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPS 492
           PRP+P   P+ PPP      P   P    A++   S++   L            SP G  
Sbjct: 25  PRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEP---------ESPSGQV 75

Query: 493 KPSLASPYLPEGTSKPLSDRPTKAPVYMPH----PETPSKPSPCLVGEASKPPAPSEGSP 548
            P  A P     +S+  S  PT  P   P     P   S+PSP  V  +  PP   E   
Sbjct: 76  GPRPAPPQEESPSSEAKSRGPTP-PAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKK 134

Query: 549 KAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLE 608
                  A    E +    A +K   ++ E +A A               ++ E   RLE
Sbjct: 135 AGERHKLAKERREERAKYLAAKKAVWLEKEEKAKA-----------LREKQLQERRRRLE 183

Query: 609 EKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPA 668
           E+R  ++A++RR  A+  + RQ+L K+     +  EA+ +   +   A+       +R +
Sbjct: 184 EQR--LKAEQRR-AALEERQRQKLEKNK----ERYEAAIQRSVKKTWAEIRQ----QRWS 232

Query: 669 GEG---QGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAAL---SSLQRDMQRLTD 722
             G      P  +      S     +P       N+ +SK SA L    S  R +Q    
Sbjct: 233 WAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAW 292

Query: 723 QQQRL--LAPPEAPGSAPPPAAWVIP--------------GPTTGPKAAS----PSPARR 762
           +   +  L  P     A   +A  +P              GPT G   AS    P P R 
Sbjct: 293 ESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRT 352

Query: 763 VPATRRSPGP-GPSQSPRSPKHTRPAELRLAPL-TRVLTPPHDVDSLPHLRKFSPSQVPV 820
            P+      P   S SP +P     +  R AP   R      +    P   +  P   PV
Sbjct: 353 HPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPV 412

Query: 821 QTRSSILLAEETPPEEPA--------ARPGLIEIPLGSLADPAAED---EGDGSPAGAED 869
           Q +       E   E+ A         R  L   P   L+   A +   +    P+    
Sbjct: 413 QKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPST 472

Query: 870 SLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKE 929
           S    AS    P  G          P+    +   +  + + RR EEA+        E +
Sbjct: 473 SWHRPASPCPSPGPGHTL------PPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDK 526

Query: 930 QRREEAARLAQEEAPGPAPLVSAVPMATPAPAAR--APAE 967
            + +  A   +E A   +P  S  P  TPAP  +   PAE
Sbjct: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAE 566



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 99/402 (24%), Positives = 158/402 (39%), Gaps = 65/402 (16%)

Query: 631 RLGKSAFLQVQPREASGEAEAEAEEADSGP--VPGGERPAGEGQGEPTS--RPKAVTFSP 686
           R   SA + V PR AS           S     P GER  GE + +P +   P  V   P
Sbjct: 351 RTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGER--GERR-KPNAGGSPAPVRRRP 407

Query: 687 DLGPVPHEGLGEYNRAVSKLSAALS---SLQRDMQRLTDQQQRL-------LAPPEAPGS 736
           +  PV  +   +  R   K  +AL+   SL++        + RL       L+P      
Sbjct: 408 EASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARP 467

Query: 737 APPPAAWVIP---------GPTTGPKAASP-----SP---ARRVPATRRSPGP-GPSQSP 778
           + P  +W  P         G T  PK  SP     SP    RR    + SP   GP    
Sbjct: 468 SSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKS 527

Query: 779 RSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPA 838
           +S +     +   AP +   +P       P  ++  P++ P  T +++L    T P  PA
Sbjct: 528 QSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETP--TDAAVL----TSPPAPA 581

Query: 839 ARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDE 898
             P     P+    D   E+           + E+    E E R+      +D+   E++
Sbjct: 582 P-PVTPSKPMAGTTD--REEATRLLAEKRRQAREQREREEQERRLQAE---RDKRMREEQ 635

Query: 899 MAQKRASLLERQQRRAEEARRRKQWQEVEKEQ-RREEAARLAQEEAPGPAPLVSAVPMAT 957
           +A++  +  ER+     EARRR++ +  EK Q  +EE  RL +++    A          
Sbjct: 636 LAREAEARAEREA----EARRREEQEAREKAQAEQEEQERLQKQKEEAEA---------- 681

Query: 958 PAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLR 999
               +R  AE +   R+  F +QE ER+ + K ++++ K  R
Sbjct: 682 ---RSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTR 720



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 58/229 (25%), Positives = 83/229 (36%), Gaps = 26/229 (11%)

Query: 438 PRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLA 497
           P P P  T    PP P    T     ++    E +  P  A         PE  S+    
Sbjct: 482 PSPGPGHTLPPKPPSPRGT-TASPKGRVRRKEEAKESPSAAG--------PEDKSQSKRR 532

Query: 498 SPYLPEGTSKPLSDRPTKAPVYMPHP---ETPSKPSPCLVGEASKPPAPSEGSPKAVASS 554
           +    E  + P S  P+ AP   P P   E P   +P      + PPAP   +P    S 
Sbjct: 533 ASNEKESAA-PASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAP---APPVTPSK 588

Query: 555 PAA--TNSEVKMTSFAERKKQL----VKAEAEAGAGSPTSTPAPPEALSSEMSELSARLE 608
           P A  T+ E      AE+++Q      + E E    +        E L+ E    + R  
Sbjct: 589 PMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREA 648

Query: 609 EKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEAD 657
           E RR  E + R       + ++RL K    Q +  EA    EAE +  +
Sbjct: 649 EARRREEQEAREKAQAEQEEQERLQK----QKEEAEARSREEAERQRLE 693



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 49/203 (24%), Positives = 71/203 (34%), Gaps = 24/203 (11%)

Query: 740 PAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQS--PRSPKHTRPAELRLAPLTRV 797
           P A +  G      A +P   R  P    SP P P  +  P +P  T PA        ++
Sbjct: 5   PRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL 64

Query: 798 LTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPL-GSLADPAA 856
              P          +  P   P Q  S    A+   P  PA  P     P   S   P A
Sbjct: 65  PLEPESPSG-----QVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTA 119

Query: 857 EDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQR---- 912
               D  P   E     E     + R          ++    +A K+A  LE++++    
Sbjct: 120 VPASDSPPTKQEVKKAGERHKLAKER---------REERAKYLAAKKAVWLEKEEKAKAL 170

Query: 913 ---RAEEARRRKQWQEVEKEQRR 932
              + +E RRR + Q ++ EQRR
Sbjct: 171 REKQLQERRRRLEEQRLKAEQRR 193


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/440 (26%), Positives = 169/440 (38%), Gaps = 65/440 (14%)

Query: 485 LHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPS 544
           L   E   +P LAS    E   +P    P+K+ +  P       PSP  VG+ S P  P+
Sbjct: 279 LRREEPDLQPQLAS----EAPRRPAQPPPSKSALLPP-------PSP-RVGKRSPPGPPA 326

Query: 545 EGSPKAVASSPAATNSEVKM---TSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMS 601
           +  P A  +SP     E  +   T+  E++ +  K+   + AG+  S P  P  LS    
Sbjct: 327 Q--PAATPTSPHRRTQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESRPQTP--LSEASG 382

Query: 602 ELSARLEEKRRAIEAQKRRIEAI--FAKHRQRLGKS----AFLQ--VQPREASGEAEAEA 653
            LSA L    R + A  R ++ +  F + R+ L +S    A L+  V  R+A    + ++
Sbjct: 383 RLSA-LGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKS 441

Query: 654 EEADSGPVPGGERPAGEGQGEPTSR-----PKAVTF---------SPDLGPVPHEGLGEY 699
           E       PG  +      G    R      KA +          + DL     + LG  
Sbjct: 442 ERGAPWGTPGASQEELRAPGSVAERRRLFQQKAASLDERTRQRSPASDLELRFAQELGRI 501

Query: 700 NRAVSK--LSAALSSLQRDMQRLTDQQQR----LLAPPEAPGS--APPPAAWVIPGPTTG 751
            R+ S+  L  +  SL+  +QR    ++     L + P  P +  A  PAA   P P++ 
Sbjct: 502 RRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAAAQPPSPSSA 561

Query: 752 PKAASPS--PARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPH 809
            K       P  R PA R  PG GP Q  R          R     R   PP   D    
Sbjct: 562 EKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSPVPPPAADPPEA 621

Query: 810 LRKFSPSQVPVQTRSSI-LLAEETPPEEPAARPGLIEIPLGSLADPAAE------DEGDG 862
             K  P +       ++  L   TP  E AA P  +E    + A P AE       E DG
Sbjct: 622 RTKAPPGRKREPPAQAVRFLPWATPGLEGAAVPQTLE---KNRAGPEAEKRLRRGPEEDG 678

Query: 863 SPAGAEDSLEEEASSEGEPR 882
            P G  D     A S+G+ R
Sbjct: 679 -PWGPWD--RRGARSQGKGR 695



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 168/711 (23%), Positives = 245/711 (34%), Gaps = 112/711 (15%)

Query: 475  PDGAADGSFYLHSPEGPSKPSLASPYLPE--GTSKPLSDRPTKAPVYMPHPETPSKP--- 529
            P G    S      E    PS+  P  PE  G+   L+D PT+    +  PET +     
Sbjct: 1914 PSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEA-LGTPETGAATPMD 1972

Query: 530  ------SPCLVGEASKPPA-PSEGSPKAVASSPAATNSEVKMTSFAERK-KQLVKAEAEA 581
                  +P    EA  P A PS G   A  +SP     E++  S AE    +    E   
Sbjct: 1973 WQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPR--RGELRRGSSAESALPRAGPRELGR 2030

Query: 582  GAGSPTSTPAPPEALSSEMSELSAR--LEEKRRAIEAQKRRIEAIFAKHRQRL------- 632
            G     S   P     S  +   AR  L E   A     +R++A+    RQRL       
Sbjct: 2031 GLHKAASVELPQRRSPSPGATRLARGGLGEGEYA-----QRLQAL----RQRLLRGGPED 2081

Query: 633  GKSAFLQVQPREASGEAEAE---AEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLG 689
            GK + L+    E+ G    +   A  A S   P  + P      E     K+ +FS    
Sbjct: 2082 GKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPL-----ENRGLQKSSSFSQGEA 2136

Query: 690  PVPHEGLGEYNRA-------VSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAA 742
                E  G + RA       V++L A        +  L++ Q    A P AP  + P +A
Sbjct: 2137 ----EPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSA 2192

Query: 743  WVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPH 802
                     P A +PS A + PA + +    P   P   + ++PA    A  T  L    
Sbjct: 2193 --------EPSATTPSDAPQPPAPQPAQDKAPEPRPEPVRASKPAPPPQALQTLALPLTP 2244

Query: 803  DVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDG 862
                +  L+    +Q P Q           PP EP  +P        +   P A ++   
Sbjct: 2245 YAQIIQSLQLSGHAQGPSQ-------GPAAPPSEP--KPHAAVFARVASPPPGAPEKRVP 2295

Query: 863  SPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKP-----EDEMAQKRASLLERQQRRAEEA 917
            S  G     E+       PR G       E+       E +  + R S L    R    +
Sbjct: 2296 SAGGPPVLAEKARVPTVPPRPGSSLSSSIENLESEAVFEAKFKRSRESPLSLGLRLLSRS 2355

Query: 918  R--RRKQWQEVEKEQ---------------RREEAARLAQE-EAPGPAPLVSAVPMA--- 956
            R   R  ++  E+E                RR E +R  Q+  A G   LV  + ++   
Sbjct: 2356 RSEERGPFRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQDLRAVGEPGLVRRLSLSLSQ 2415

Query: 957  ----TPAPAARAPAEEEVG-----PRKGDFTRQEYERRAQLKLMDDLDKV-LRPRAAGSG 1006
                TP PA R PA E  G        G   R       + +L   L+++  R + +GS 
Sbjct: 2416 RLRRTP-PAQRHPAWEARGGDGESSEGGSSARGSPVLAMRRRLSFTLERLSSRLQRSGSS 2474

Query: 1007 GPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVK 1066
                G    + P  G      L R+ + G    RL   ++Q           A +     
Sbjct: 2475 EDSGGASGRSTPLFG-----RLRRATSEGESLRRLGLPHNQLAAQAGATTPSAESLGSEA 2529

Query: 1067 RPTSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPS 1117
              TS + +P    S  R   SR R  +  S  +  ASV E  G +  +  S
Sbjct: 2530 SATSGSSAPGESRSRLRWGFSRPRKDKGLSPPNLSASVQEELGHQYVRSES 2580



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 94/370 (25%), Positives = 137/370 (37%), Gaps = 69/370 (18%)

Query: 701  RAVS-KLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGP-KAASPS 758
            RA+S  +S   S L+R+   L  Q Q     P  P   PP  + ++P P+    K + P 
Sbjct: 266  RALSIHVSVPQSGLRREEPDL--QPQLASEAPRRPAQPPPSKSALLPPPSPRVGKRSPPG 323

Query: 759  PARRVPATRRSPGPGPSQSPRSPKHTRPAELR----------LAPL--TRVLTPPHDVDS 806
            P  +  AT  SP    +Q P  P+ T   E R          LA    +R  TP  +   
Sbjct: 324  PPAQPAATPTSPHRR-TQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESRPQTPLSEASG 382

Query: 807  LPHLRKFSPSQVPV-----------QTRSSILLAEETPPEEPAARPGLIEIPLGSLADPA 855
                   SP  V             + R   L   ++PP     RP +      SL  P 
Sbjct: 383  RLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAP--LRPWVPLRKARSLEQPK 440

Query: 856  AEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAE 915
            +E    G+P G   + +EE  + G        F + +    DE  ++R+   + + R A+
Sbjct: 441  SER---GAPWGTPGASQEELRAPGSVAERRRLF-QQKAASLDERTRQRSPASDLELRFAQ 496

Query: 916  EARRRKQWQEVEKEQRREEAARLAQEEAPGP-----APLVS--AVPMATPA--PAARAPA 966
            E  R ++    E+  R  E+ R   + AP P      PL S  + P  + A  PAA  P 
Sbjct: 497  ELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAAAQPP 556

Query: 967  EEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGG---PGRGGRRATRPRSGCC 1023
                  + G                   D+  RPR+ G  G   PG G ++  R R    
Sbjct: 557  SPSSAEKPG-------------------DEPGRPRSRGPAGRTEPGEGPQQEVRRR---- 593

Query: 1024 DDSALARSPA 1033
            D   L RS A
Sbjct: 594  DQFPLTRSRA 603



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 60/231 (25%), Positives = 90/231 (38%), Gaps = 27/231 (11%)

Query: 676  TSRPKAVTFSPDLGPVPHEGLGEYNRAVSKL-------SAALSSLQRDMQRLTDQQQRLL 728
            T  P  VT    +      G G ++ +  K+       S+A+ S       +T +  R  
Sbjct: 2736 THLPVGVTVRFRVACANRAGQGPFSNSSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARA- 2794

Query: 729  APPEAPGSAPPPAAWVIPGP--TTGPKAASPSPARRVPATRRSPGPGPSQSPRSPK---H 783
             PP++P S  PP A   P P   T   ++ P+P  +  ++ ++ GP P   PR  +    
Sbjct: 2795 RPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPTPPSQALSSLKAVGPPPQTPPRRHRGLQA 2854

Query: 784  TRPAELRLAPLTRVLTP----PHDVD-------SLPHLRKFSPSQVPVQTRSSILLAEET 832
             RPAE  L P T V TP    P  +D       S P   K   S  PV   +S + A   
Sbjct: 2855 ARPAEPTL-PSTHV-TPSEPKPFVLDTGTPIPASTPQGVKPVSSSTPVYVVTSFVSAPPA 2912

Query: 833  P-PEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPR 882
            P P  P   P   ++ + SL+         GS   +    E     +G P+
Sbjct: 2913 PEPPAPEPPPEPTKVTVQSLSPAKEVVSSPGSSPRSSPRPEGTTLRQGPPQ 2963



 Score = 38.1 bits (87), Expect = 0.053
 Identities = 73/310 (23%), Positives = 106/310 (34%), Gaps = 45/310 (14%)

Query: 377  LKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLG 436
            L+ SPS+S   AL +A     +RP   A   STP   +         P       +    
Sbjct: 2161 LQESPSLS---ALSEAQPSSPARP--SAPKPSTPKSAEPSATTPSDAPQPPAPQPAQDKA 2215

Query: 437  P-PRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPS 495
            P PRP P R  ++P P P  L T+   L         L   G A         +GPS+  
Sbjct: 2216 PEPRPEPVRA-SKPAPPPQALQTLALPLTPYAQIIQSLQLSGHA---------QGPSQGP 2265

Query: 496  LASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASK----PPAPS------- 544
             A P  P+  +   + R    P   P    PS   P ++ E ++    PP P        
Sbjct: 2266 AAPPSEPKPHAAVFA-RVASPPPGAPEKRVPSAGGPPVLAEKARVPTVPPRPGSSLSSSI 2324

Query: 545  ---------EGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEA 595
                     E   K    SP +    +   S +E +     AE E G   P+    P E 
Sbjct: 2325 ENLESEAVFEAKFKRSRESPLSLGLRLLSRSRSEERGPFRGAEEEDGIYRPSPAGTPLEL 2384

Query: 596  LSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQP----REASGEAEA 651
            +     E S  +++ R     +   +  +     QRL ++   Q  P    R   GE+  
Sbjct: 2385 V--RRPERSRSVQDLRAV--GEPGLVRRLSLSLSQRLRRTPPAQRHPAWEARGGDGESSE 2440

Query: 652  EAEEADSGPV 661
                A   PV
Sbjct: 2441 GGSSARGSPV 2450



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 16/131 (12%)

Query: 483  FYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSP--CLVGEASKP 540
            F   + +  + PS A    P  TS+P   RP  +P  +  P  P+ P+P    V  +S P
Sbjct: 2767 FVRGTQDSSAVPSAAHQEAPV-TSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPP 2825

Query: 541  PAPSE--GSPKAVASSP-----------AATNSEVKMTSFAERKKQLVKAEAEAGAGSPT 587
              PS+   S KAV   P           AA  +E  + S      +      + G   P 
Sbjct: 2826 TPPSQALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPA 2885

Query: 588  STPAPPEALSS 598
            STP   + +SS
Sbjct: 2886 STPQGVKPVSS 2896



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 83/355 (23%), Positives = 116/355 (32%), Gaps = 88/355 (24%)

Query: 775  SQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPP 834
            S++PR P    P++  L P      PP      P + K SP                 PP
Sbjct: 292  SEAPRRPAQPPPSKSALLP------PPS-----PRVGKRSPPG---------------PP 325

Query: 835  EEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDK 894
             +PAA P              +       P   ED+  EE   +     G       E +
Sbjct: 326  AQPAATP-------------TSPHRRTQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESR 372

Query: 895  PEDEMAQK--RASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSA 952
            P+  +++   R S L R  R      R     +  +E+RR     L + ++P PAPL   
Sbjct: 373  PQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRS----LERSDSP-PAPLRPW 427

Query: 953  VPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGG 1012
            VP+   A +   P  E   P       QE                   RA GS    R  
Sbjct: 428  VPLRK-ARSLEQPKSERGAPWGTPGASQE-----------------ELRAPGSVAERR-- 467

Query: 1013 RRATRPRSGCCDDSALARSPARGL-------LG------SRLSKIYSQSTLSLSTVANEA 1059
             R  + ++   D+    RSPA  L       LG      SR   + S  +L  +     +
Sbjct: 468  -RLFQQKAASLDERTRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPS 526

Query: 1060 HNNLG----VKRP----TSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPE 1106
                G      RP    TSRA SP+    PS     +  D      +  PA   E
Sbjct: 527  PREPGEPPLFSRPSTPKTSRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPAGRTE 581



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 54/249 (21%), Positives = 75/249 (30%), Gaps = 46/249 (18%)

Query: 431  SSDSLGPPRPAPARTPTQPPP---EPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHS 487
            + DS   P  A    P    P    P D PT         S  P L P      S  +  
Sbjct: 2771 TQDSSAVPSAAHQEAPVTSRPARARPPDSPT---------SLAPPLAPAAPTPPSVTVSP 2821

Query: 488  PEGPSKPSLA---------SPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEAS 538
               P+ PS A          P  P    + L       P       TPS+P P ++   +
Sbjct: 2822 SSPPTPPSQALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGT 2881

Query: 539  KPPAPSEGSPKAVASS-----------------PAATNSEVKMTSFAERKKQLVKAEAEA 581
              PA +    K V+SS                 P A     + T    +     K    +
Sbjct: 2882 PIPASTPQGVKPVSSSTPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAKEVVSS 2941

Query: 582  GAGSPTSTPAPPEAL--SSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQ 639
               SP S+P P           +    LEEK R       R   + A      G++   +
Sbjct: 2942 PGSSPRSSPRPEGTTLRQGPPQKPYTFLEEKARG------RFGVVRACRENATGRTFVAK 2995

Query: 640  VQPREASGE 648
            + P  A G+
Sbjct: 2996 IVPYAAEGK 3004


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 85/348 (24%), Positives = 129/348 (37%), Gaps = 67/348 (19%)

Query: 393 WNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVL----LRSVSSDSLGPPRPAPARTPTQ 448
           W R+  R +S A +   P  +++ ++ V+GD       L++ S  +  P +      P  
Sbjct: 258 WERE--RRISSAAA---PASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLA 312

Query: 449 PPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPE-GTSK 507
           PPP P                    LP G A  S  L  P GP  P    P LP  G   
Sbjct: 313 PPPPPP-------------------LPPGPAQASVALPPPPGPPPP----PPLPSTGPPP 349

Query: 508 PLSDRPTKAPVYMPHPETPSKPSPC---LVGEASKPPAPSEGSPKAVASSPAATNSEVKM 564
           P    P    V  P P  P+ P P     +   S+   P  G   A+A +     S ++ 
Sbjct: 350 PPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMED 409

Query: 565 TSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAI 624
           TSF      +    A +   +       P   S  M E+SA L  +RR  E         
Sbjct: 410 TSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAE--------- 460

Query: 625 FAKHRQRLGKSAFLQVQPREASGE-AEAEAEEADSGPVPGGERPAGE------GQGEPT- 676
                    K + ++ + +E  GE +E    +A S   P   R   E      G   P  
Sbjct: 461 ---------KGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVI 511

Query: 677 SRPKAVTFS-PDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQ 723
           SRPK+   S P    V  EGL +Y+R    +   L  +++++ +L ++
Sbjct: 512 SRPKSTPLSQPSANGVQTEGL-DYDRLKQDI---LDEMRKELTKLKEE 555



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 80/354 (22%), Positives = 122/354 (34%), Gaps = 46/354 (12%)

Query: 594 EALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEA 653
           E L  E  E   +  E++  +E Q+R       + ++RL +    + Q RE     E E 
Sbjct: 184 ERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER-QERQERERLERLERER 242

Query: 654 EEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSL 713
           +E +       E+   E +   +S     +    L  V    LG+ + +   L AA    
Sbjct: 243 QERERQEQLEREQLEWERERRISSAAAPASVETPLNSV----LGDSSASEPGLQAASQPA 298

Query: 714 QRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPG 773
           +      T  QQ ++  P AP   PP    + PGP     A  P P    P    S GP 
Sbjct: 299 E------TPSQQGIVLGPLAPPPPPP----LPPGPAQASVALPPPPGPPPPPPLPSTGPP 348

Query: 774 PSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP 833
           P   P              PL   + PP             P   P    S   LA  + 
Sbjct: 349 PPPPP-------------PPLPNQVPPPP-----------PPPPAPPLPASGFFLASMSE 384

Query: 834 PEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDED 893
              P    GL     G+     +  E    P+G        ASS+ +   G G       
Sbjct: 385 DNRPLT--GLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGS 442

Query: 894 KPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEK-EQRREEAARLAQEEAPGP 946
              +EM    ++LL R++R AE+    +  Q+ +K E      ++ +    P P
Sbjct: 443 GLMEEM----SALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEP 492


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
            sapiens]
          Length = 2715

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 137/595 (23%), Positives = 201/595 (33%), Gaps = 112/595 (18%)

Query: 488  PEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPS--- 544
            P  P  PS   P  P  TS P        P   P P  P  P P      S PP P+   
Sbjct: 405  PLTPPAPSPPPPLPPPSTSPP--------PPLCPPPPPPVSPPPL----PSPPPPPAQEE 452

Query: 545  --EGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA-----PPEALS 597
              E  P  V ++ +       +T     +++  +A  E G   PT TP+     PPE   
Sbjct: 453  QEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPE-GTSPPTPTPSTATGGPPEDSP 511

Query: 598  SEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEAD 657
            +   + +  L+  R+        I  + +    R+ K+      PR    E   +  + +
Sbjct: 512  TVAPKSTTFLKNIRQF-------IMPVVSARSSRVIKT------PRRFMDEDPPKPPKVE 558

Query: 658  SGPV---PGGERPAGEGQGEPT-SRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSL 713
              PV   P    P    +  P  S P+A T  P   PVP   L E  R++         L
Sbjct: 559  VSPVLRPPITTSPPVPQEPAPVPSPPRAPT--PPSTPVP---LPEKRRSI---------L 604

Query: 714  QRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPK-------------------- 753
            +    R T   + L  PP AP   PPPA    P P T  +                    
Sbjct: 605  REPTFRWTSLTRELPPPPPAP--PPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIY 662

Query: 754  --AASPSPARRVPATRRSPGPGPSQSPRSPKHT---RPAELRLAPLTRVLTPPHDVDSLP 808
                +P P     A    P P    SP  P+     R   L L     V+T P   +  P
Sbjct: 663  ESVLTPPPLGAPEAPEPEPPPA-DDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSP 721

Query: 809  H----LRKFSPSQV----PVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEG 860
            H    L     +Q     P+Q   + LL +  PP +P  +P      +  L        G
Sbjct: 722  HGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVG 781

Query: 861  DGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRR 920
                +G E+ +          R  +  F  D+ + +   A    S   + +  A   ++ 
Sbjct: 782  SLPLSGVEEKMFSLLK-----RAKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQI 836

Query: 921  KQWQEVEKEQRREEA--ARLAQEEAPGPAPLVSAV--PMATPAPAARAPAEEEVGPR--- 973
                 V  E    EA   R +  E+P   P +  V    A     ARA   E+V PR   
Sbjct: 837  SDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDV-PRLSA 895

Query: 974  -----KGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGG----PGRGGRRATRPR 1019
                 + D   ++    ++ + +    +  +  AAG GG     G GG  A  PR
Sbjct: 896  LPLRDRQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPR 950



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 127/555 (22%), Positives = 189/555 (34%), Gaps = 115/555 (20%)

Query: 334 SPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAW 393
           S R    +      G+S P  T   P  ++GGP  P    T + KS+  + ++       
Sbjct: 477 SQRAEREAARAGPEGTSPPTPT---PSTATGGP--PEDSPTVAPKSTTFLKNI------- 524

Query: 394 NRQLSRPLSQAVS---FSTPFG-LDSDVDV---VMGDPVLLRSVSSDSLGPPRPAPARTP 446
            RQ   P+  A S     TP   +D D      V   PVL   +++    P  PAP  +P
Sbjct: 525 -RQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSP 583

Query: 447 TQPPPEPG-DLPTIEEALQIIH------SAEPRLLPDGAADGSFYLHSPEGPSKPSLASP 499
            + P  P   +P  E+   I+       ++  R LP            P  P  P   SP
Sbjct: 584 PRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPP----------PPPAPPPPPAPSP 633

Query: 500 YLPEGTSKPLSDRP--TKAPVYMPHP------ETPSKPSPCLVGEASKP-PAPSEGSPKA 550
                TS   S RP   +AP + P        E+   P P    EA +P P P++ SP  
Sbjct: 634 PPAPATS---SRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAE 690

Query: 551 VASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEK 610
                    + + +  FA      VKAE      SP   PA      S   +  A+L + 
Sbjct: 691 PEPRAVGRTNHLSLPRFAPVVTTPVKAEV-----SPHGAPA-----LSNGPQTQAQLLQP 740

Query: 611 RRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGE 670
            +A++ Q                                     +A   P P  + P   
Sbjct: 741 LQALQTQL----------------------------------LPQALPPPQPQLQPPPSP 766

Query: 671 GQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAP 730
            Q  P  + +       +G +P  G+ E      K+ + L   +  + ++  QQQ+ +A 
Sbjct: 767 QQMPPLEKARIA----GVGSLPLSGVEE------KMFSLLKRAKVQLFKIDQQQQQKVAA 816

Query: 731 --PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAE 788
             P +PG      A  +   +      S   +      R S    P Q PR     R A 
Sbjct: 817 SMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAA 876

Query: 789 LRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPL 848
           + L     ++  P DV  L  L       +  +  SS   A ET      +R G +E   
Sbjct: 877 VALGQARAMV--PEDVPRLSALPLRDRQDLATEDTSS---ASETESVPSRSRRGKVE--- 928

Query: 849 GSLADPAAEDEGDGS 863
              A P  E E  GS
Sbjct: 929 --AAGPGGESEPTGS 941



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 98/424 (23%), Positives = 138/424 (32%), Gaps = 102/424 (24%)

Query: 446  PTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAAD----------GSFYLHSP----EGP 491
            P  P  EP  L   EE   I+HS  P   P G  D          G+   HSP    + P
Sbjct: 1785 PWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPP 1844

Query: 492  SKPSLASPYLPEGTSKPLSDRPTKAPVY--------------MPHPETPSK--------- 528
             +P   S   P    +  S    K P Y              +P P +PS          
Sbjct: 1845 LRPDSGS--APPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVG 1902

Query: 529  ----PSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAG 584
                P+P        P AP    P   AS P  T+ ++++         L     E    
Sbjct: 1903 DPDFPAPPRRSRRPSPLAP-RPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPP 1961

Query: 585  SPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPRE 644
             P  +P PPE L  +  ++          + +     +  FA        ++ L  +P +
Sbjct: 1962 GPAPSPPPPEDLGPDFEDME---------VVSGLSAADLDFA--------ASLLGTEPFQ 2004

Query: 645  ASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSR----PKAVTFSPDLGPVPHEGLGEYN 700
                 E        G   GG   + E +  PTSR    P  V  +P L P    G     
Sbjct: 2005 -----EEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPR-- 2057

Query: 701  RAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPG-------------SAPP---PAAWV 744
              + +L         + + +  Q +    PP  PG             + PP   P+  V
Sbjct: 2058 --IEQLDGVDDGTDSEAEAV-QQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIV 2114

Query: 745  ------IPGP---TTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLT 795
                  + GP     GP+  S  PA  + A    P  G + SP  P  T  A L  AP  
Sbjct: 2115 DFVLKNLGGPGDGGAGPREESLPPAPPL-ANGSQPSQGLTASPADPTRTF-AWLPGAPGV 2172

Query: 796  RVLT 799
            RVL+
Sbjct: 2173 RVLS 2176



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 81/362 (22%), Positives = 104/362 (28%), Gaps = 59/362 (16%)

Query: 432 SDSLGPPRPAPARTPTQPPPEPG------------DLPTIEEALQIIHSAEPRLLPDGAA 479
           S S  PP   P   P  PPP P               P +  A        P L P   A
Sbjct: 421 STSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRA 480

Query: 480 DGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAP-----------VYMP------- 521
           +       PEG S P   +P     T  P  D PT AP             MP       
Sbjct: 481 EREAARAGPEGTSPP---TPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSS 537

Query: 522 ---------HPETPSKPSPCLVGEASKPP----APSEGSPKAVASSPAATNSEVKMTSFA 568
                      E P KP    V    +PP     P    P  V S P A           
Sbjct: 538 RVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLP 597

Query: 569 ERKKQLVKAE----AEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAI 624
           E+++ +++             P   PAPP   +       A    +   + A +      
Sbjct: 598 EKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEA 657

Query: 625 FAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTF 684
             K  +     + L   P  A    E E   AD  P     R  G        R   V  
Sbjct: 658 HLKIYE-----SVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVT 712

Query: 685 SPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWV 744
           +P    V   G      A+S      + L + +Q L  Q      PP  P   PPP+   
Sbjct: 713 TPVKAEVSPHGA----PALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQ 768

Query: 745 IP 746
           +P
Sbjct: 769 MP 770



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 42/166 (25%), Positives = 65/166 (39%), Gaps = 18/166 (10%)

Query: 731  PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPG----PGPSQSPRSPKHTRP 786
            P AP   PPP+ W  P   T P+   P P   V A   + G    PGP+ SP  P+   P
Sbjct: 1918 PLAP--RPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGP 1975

Query: 787  AELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETP----PEEPAARPG 842
                +  ++ +     D+D    L    P Q  +    ++  +   P     EE +    
Sbjct: 1976 DFEDMEVVSGLSAA--DLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSR 2033

Query: 843  LIEIPLGSLADPA-AEDEGDGSPA-----GAEDSLEEEASSEGEPR 882
             I  P+  ++ P  A     G+P      G +D  + EA +  +PR
Sbjct: 2034 YIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPR 2079



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 114/547 (20%), Positives = 171/547 (31%), Gaps = 119/547 (21%)

Query: 428 RSVSSDSLGPPR-----PAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGS 482
           R   +  L PPR     P P +TP +   E G    ++   +++  A+    P   A   
Sbjct: 154 RKHKTTPLPPPRLADVAPTPPKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRAC-- 211

Query: 483 FYLHSPEGPSKPSLASPYLPEGTSKPLSDRPT--KAPVYMPHPETPSKPSPCLVGEAS-- 538
                P  P +     P  P G  +         +A V +P PE P    P      S  
Sbjct: 212 ----EPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWK 267

Query: 539 --KPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEAL 596
             + P P  G+P+    S                           G G P        A 
Sbjct: 268 CKEGPGPGPGTPRRGGQSSRGGRGG---------------RGRGRGGGLPFVIKFVSRAK 312

Query: 597 SSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEA 656
             +M +LS  LE                                     SG+ + + EE+
Sbjct: 313 KVKMGQLSLGLE-------------------------------------SGQGQGQHEES 335

Query: 657 DSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRD 716
               VP  +R  G GQG      K      D      E   +      K   A++  +  
Sbjct: 336 WQD-VP--QRRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVA--EEM 390

Query: 717 MQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQ 776
           M     ++ +L  PP  P +  PP    +P P+T P    P P    P    SP P PS 
Sbjct: 391 MPAAEKEEAKLPPPPLTPPAPSPPPP--LPPPSTSP----PPPLCPPPPPPVSPPPLPSP 444

Query: 777 SPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEE 836
            P  P      E          +PP  V +    ++  P   P Q             E 
Sbjct: 445 PP-PPAQEEQEE----------SPPPVVPATCSRKRGRPPLTPSQR-----------AER 482

Query: 837 PAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPE 896
            AAR G    P G+           G P     ++  ++++          F K+  +  
Sbjct: 483 EAARAG----PEGTSPPTPTPSTATGGPPEDSPTVAPKSTT----------FLKNIRQFI 528

Query: 897 DEMAQKRASLLERQQRR-AEEARRRKQWQEVEKEQRR--EEAARLAQEEAPGPAPLVSAV 953
             +   R+S + +  RR  +E   +    EV    R     +  + QE AP P+P  +  
Sbjct: 529 MPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPT 588

Query: 954 PMATPAP 960
           P +TP P
Sbjct: 589 PPSTPVP 595



 Score = 33.9 bits (76), Expect = 1.00
 Identities = 50/210 (23%), Positives = 67/210 (31%), Gaps = 28/210 (13%)

Query: 642  PREASGEAEAEAEEAD--SGPVPGGERPAGEGQ---------GEPTSRPKAVTFSPDLGP 690
            PRE     EA  E       P P  E P GE           G P          P L P
Sbjct: 1788 PREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRP 1847

Query: 691  VPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTT 750
                      R+ S     + +     + L         P  +PGS   P++     PT 
Sbjct: 1848 DSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVS---FGPLPSPGS---PSSLTHHIPTV 1901

Query: 751  GPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLT----------P 800
            G       P R    +  +P P PS+    P  T P +LR+ P T V+T          P
Sbjct: 1902 GDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSP-QLRVPPPTSVVTALTPTSGELAP 1960

Query: 801  PHDVDSLPHLRKFSPSQVPVQTRSSILLAE 830
            P    S P      P    ++  S +  A+
Sbjct: 1961 PGPAPSPPPPEDLGPDFEDMEVVSGLSAAD 1990


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 105/433 (24%), Positives = 147/433 (33%), Gaps = 88/433 (20%)

Query: 580 EAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQ 639
           E G G  T   A P  L+ + SELS  L+        +   +    +  ++ +G  +   
Sbjct: 570 ENGEGPAT---AGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARS--- 623

Query: 640 VQPREASGEAEAEAEEADSG--PVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLG 697
                 SG ++ +     SG  P P  ER   EG   P   PK  +  P  GP P+  + 
Sbjct: 624 ----RGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERP---PKLCSSLPGQGPPPYVFMY 676

Query: 698 EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASP 757
                                            P +P   PPP A        GP A  P
Sbjct: 677 PQGS-----------------------------PSSPAPGPPPGAPWAFSYLAGPPATPP 707

Query: 758 SPARRVPATRRSPGPGPSQSPRSPKHTRPAELRL---APLTR------------VLTP-- 800
            P R    +     PGP++     +   P    L   A LTR             +TP  
Sbjct: 708 DPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTP 767

Query: 801 ----PHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPP---EEPAARPGLIEIPLGSLAD 853
               P         R+  P   P +  SS+      PP   E P  + G       +L++
Sbjct: 768 ARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSE 827

Query: 854 PAAEDEGDGSPAGA---EDSLEEEASSEGEP----RVGLGFFYKDEDKPEDEMAQKRASL 906
           PA   E  G PA A    D+ EEE   EG P      G G  + +E     +   K A  
Sbjct: 828 PAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGP 887

Query: 907 LERQQ----------RRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPA-PLVSAVPM 955
             R+             ++  +RR + +E E  Q    A  +A    PGPA PL S  P 
Sbjct: 888 PPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASA-TPGPAAPLPSPTPG 946

Query: 956 ATPAPAARAPAEE 968
            +P PA+  P  E
Sbjct: 947 ESP-PASSLPQPE 958



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 120/479 (25%), Positives = 163/479 (34%), Gaps = 68/479 (14%)

Query: 319  PDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLK 378
            P   Q ++LP+G    P+   + P     G   P + F +P    G P SP   + G   
Sbjct: 642  PSPPQERNLPEGTERPPKLCSSLP-----GQGPPPYVFMYP---QGSPSSP---APGPPP 690

Query: 379  SSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPV--LLRSVSSDSLG 436
             +P      A   A      RP  ++ S S P   + D +     PV   L S ++ +  
Sbjct: 691  GAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRR 750

Query: 437  PPRPAPARTPTQPPPEP--GDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKP 494
            P R A  RT     P P  G   +   AL+      P   P   +  S    SPE P  P
Sbjct: 751  PGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSG--PSPEPP--P 806

Query: 495  SLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASS 554
               SP   EG + P   R    P     P  P  P+        + P P EG+P +  SS
Sbjct: 807  LDESPGPKEGATGPRR-RTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP-EGTPPSRGSS 864

Query: 555  PAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAI 614
                        FAE     +K   +     P  TP PP    +     + +   K R  
Sbjct: 865  GEGL-------PFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCRER 917

Query: 615  EAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGE 674
            E  +  + A F       G +A L   P    G    E+  A S P P  E  +   QG 
Sbjct: 918  EPLQTALLA-FGVASATPGPAAPL---PSPTPG----ESPPASSLPQP--EPSSLPAQGV 967

Query: 675  PTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAP 734
            PT    +    P + P P  GL          S+A S    + +           PP AP
Sbjct: 968  PTPLAPSPAMQPPVPPCPGPGLE---------SSAASRWNGETE-----------PPAAP 1007

Query: 735  GSAPPPAAWVIPGPTTGPKAASPSPARRV-----PATRRSPGPGPSQSPRSPKHTRPAE 788
                  A   +PG  T PK  S +  +        A R  P P P   P S     P +
Sbjct: 1008 A-----ALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQ 1061



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 120/501 (23%), Positives = 171/501 (34%), Gaps = 91/501 (18%)

Query: 428  RSVSSDSLGPPRPAPARTPTQPPPEP--GDLPTIEEALQIIHSAEPRLLPDGAADGSFYL 485
            RS S +S+G        +  QP P+P  GD    +E          R LP+G        
Sbjct: 612  RSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQE----------RNLPEGTERPPKLC 661

Query: 486  HSPEGPSKPSLASPYLPEGTSKPLSDRPTKAP---VYMPHPET--PSKPSPCLVGEASKP 540
             S  G   P     Y     S P    P  AP    Y+  P    P  P P     +   
Sbjct: 662  SSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSR 721

Query: 541  PAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA--------- 591
            P P+EG  +  A  P  +     + S+A   ++  ++     + S T TPA         
Sbjct: 722  PGPTEGDAEGEAEGPVGST----LGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSF 777

Query: 592  --------PPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQP- 642
                    PP      +S +S    E     E+   + E      R+ L + A     P 
Sbjct: 778  ALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPK-EGATGPRRRTLSEPAGPSEPPG 836

Query: 643  REASGEAEAEAEEADSGP--VPGGERPAGEG-----QGEPT--SRPKAVTFSPDLGPVPH 693
              A     ++ EE + GP   P     +GEG     +G  T   RPK     P   PVP 
Sbjct: 837  PPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP- 895

Query: 694  EGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLA--------------PPEAPGSAPP 739
             GL ++N   S  +       R+ + L   Q  LLA              P   PG +PP
Sbjct: 896  PGL-DFNLTESD-TVKRRPKCREREPL---QTALLAFGVASATPGPAAPLPSPTPGESPP 950

Query: 740  PAAWVIPGPTTGPKAASPSPARRVPATRR--SPGPGPS-QSPRSPKHTRPAELRLAPLTR 796
             ++   P P++ P    P+P    PA +    P PGP  +S  + +     E   AP   
Sbjct: 951  ASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAAL 1010

Query: 797  VLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAA 856
            +  P             +P  V V   +   LA   P   P   P         +  P  
Sbjct: 1011 LKVPGAGT---------APKPVSV---ACTQLAFSGPKLAPRLGP-------RPVPPPRP 1051

Query: 857  EDEGDGSPAGAEDSLEEEASS 877
            E  G   P  A+  LE+ +SS
Sbjct: 1052 ESTGTVGPGQAQQRLEQTSSS 1072


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 105/433 (24%), Positives = 147/433 (33%), Gaps = 88/433 (20%)

Query: 580  EAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQ 639
            E G G  T   A P  L+ + SELS  L+        +   +    +  ++ +G  +   
Sbjct: 652  ENGEGPAT---AGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARS--- 705

Query: 640  VQPREASGEAEAEAEEADSG--PVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLG 697
                  SG ++ +     SG  P P  ER   EG   P   PK  +  P  GP P+  + 
Sbjct: 706  ----RGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERP---PKLCSSLPGQGPPPYVFMY 758

Query: 698  EYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASP 757
                                             P +P   PPP A        GP A  P
Sbjct: 759  PQGS-----------------------------PSSPAPGPPPGAPWAFSYLAGPPATPP 789

Query: 758  SPARRVPATRRSPGPGPSQSPRSPKHTRPAELRL---APLTR------------VLTP-- 800
             P R    +     PGP++     +   P    L   A LTR             +TP  
Sbjct: 790  DPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTP 849

Query: 801  ----PHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPP---EEPAARPGLIEIPLGSLAD 853
                P         R+  P   P +  SS+      PP   E P  + G       +L++
Sbjct: 850  ARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSE 909

Query: 854  PAAEDEGDGSPAGA---EDSLEEEASSEGEP----RVGLGFFYKDEDKPEDEMAQKRASL 906
            PA   E  G PA A    D+ EEE   EG P      G G  + +E     +   K A  
Sbjct: 910  PAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGP 969

Query: 907  LERQQ----------RRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPA-PLVSAVPM 955
              R+             ++  +RR + +E E  Q    A  +A    PGPA PL S  P 
Sbjct: 970  PPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASA-TPGPAAPLPSPTPG 1028

Query: 956  ATPAPAARAPAEE 968
             +P PA+  P  E
Sbjct: 1029 ESP-PASSLPQPE 1040



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 120/479 (25%), Positives = 163/479 (34%), Gaps = 68/479 (14%)

Query: 319  PDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLK 378
            P   Q ++LP+G    P+   + P     G   P + F +P    G P SP   + G   
Sbjct: 724  PSPPQERNLPEGTERPPKLCSSLP-----GQGPPPYVFMYP---QGSPSSP---APGPPP 772

Query: 379  SSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPV--LLRSVSSDSLG 436
             +P      A   A      RP  ++ S S P   + D +     PV   L S ++ +  
Sbjct: 773  GAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRR 832

Query: 437  PPRPAPARTPTQPPPEP--GDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKP 494
            P R A  RT     P P  G   +   AL+      P   P   +  S    SPE P  P
Sbjct: 833  PGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSG--PSPEPP--P 888

Query: 495  SLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASS 554
               SP   EG + P   R    P     P  P  P+        + P P EG+P +  SS
Sbjct: 889  LDESPGPKEGATGPRR-RTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP-EGTPPSRGSS 946

Query: 555  PAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAI 614
                        FAE     +K   +     P  TP PP    +     + +   K R  
Sbjct: 947  GEGL-------PFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCRER 999

Query: 615  EAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGE 674
            E  +  + A F       G +A L   P    G    E+  A S P P  E  +   QG 
Sbjct: 1000 EPLQTALLA-FGVASATPGPAAPL---PSPTPG----ESPPASSLPQP--EPSSLPAQGV 1049

Query: 675  PTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAP 734
            PT    +    P + P P  GL          S+A S    + +           PP AP
Sbjct: 1050 PTPLAPSPAMQPPVPPCPGPGLE---------SSAASRWNGETE-----------PPAAP 1089

Query: 735  GSAPPPAAWVIPGPTTGPKAASPSPARRV-----PATRRSPGPGPSQSPRSPKHTRPAE 788
                  A   +PG  T PK  S +  +        A R  P P P   P S     P +
Sbjct: 1090 A-----ALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQ 1143



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 120/501 (23%), Positives = 171/501 (34%), Gaps = 91/501 (18%)

Query: 428  RSVSSDSLGPPRPAPARTPTQPPPEP--GDLPTIEEALQIIHSAEPRLLPDGAADGSFYL 485
            RS S +S+G        +  QP P+P  GD    +E          R LP+G        
Sbjct: 694  RSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQE----------RNLPEGTERPPKLC 743

Query: 486  HSPEGPSKPSLASPYLPEGTSKPLSDRPTKAP---VYMPHPET--PSKPSPCLVGEASKP 540
             S  G   P     Y     S P    P  AP    Y+  P    P  P P     +   
Sbjct: 744  SSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSR 803

Query: 541  PAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPA--------- 591
            P P+EG  +  A  P  +     + S+A   ++  ++     + S T TPA         
Sbjct: 804  PGPTEGDAEGEAEGPVGST----LGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSF 859

Query: 592  --------PPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQP- 642
                    PP      +S +S    E     E+   + E      R+ L + A     P 
Sbjct: 860  ALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPK-EGATGPRRRTLSEPAGPSEPPG 918

Query: 643  REASGEAEAEAEEADSGP--VPGGERPAGEG-----QGEPT--SRPKAVTFSPDLGPVPH 693
              A     ++ EE + GP   P     +GEG     +G  T   RPK     P   PVP 
Sbjct: 919  PPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP- 977

Query: 694  EGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLA--------------PPEAPGSAPP 739
             GL ++N   S  +       R+ + L   Q  LLA              P   PG +PP
Sbjct: 978  PGL-DFNLTESD-TVKRRPKCREREPL---QTALLAFGVASATPGPAAPLPSPTPGESPP 1032

Query: 740  PAAWVIPGPTTGPKAASPSPARRVPATRR--SPGPGPS-QSPRSPKHTRPAELRLAPLTR 796
             ++   P P++ P    P+P    PA +    P PGP  +S  + +     E   AP   
Sbjct: 1033 ASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAAL 1092

Query: 797  VLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAA 856
            +  P             +P  V V   +   LA   P   P   P         +  P  
Sbjct: 1093 LKVPGAGT---------APKPVSV---ACTQLAFSGPKLAPRLGP-------RPVPPPRP 1133

Query: 857  EDEGDGSPAGAEDSLEEEASS 877
            E  G   P  A+  LE+ +SS
Sbjct: 1134 ESTGTVGPGQAQQRLEQTSSS 1154


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 90/352 (25%), Positives = 116/352 (32%), Gaps = 53/352 (15%)

Query: 689 GPVPHEGLGEYN-----RAVSKLSAALSSLQRDMQRLTDQQQRLL--APPEAPGSAPPPA 741
           GP P     E       RAV ++S   S   R+  R+   ++     APP AP  AP  A
Sbjct: 63  GPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPAPPRAPRGAPAAA 122

Query: 742 AWVIPGPTTGP-------KAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPL 794
           A   P PT  P        AA+P+ A R  A   +  P P  +   P+  R A L   P 
Sbjct: 123 AAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPP 182

Query: 795 T-------------RVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARP 841
                         R   PP      P L        P Q +       + PPE  A R 
Sbjct: 183 APAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRA 242

Query: 842 GLIEIPLGSLADPAAEDEGDGSPAG------AEDSLEEEASSEGE-PRVGLGFFYKDEDK 894
           G    P+ SL +      G G   G       +  LEEEA++ G   R  LG        
Sbjct: 243 GGAARPV-SLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGD 301

Query: 895 PEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAP---------- 944
                    ++   R +R  EE    K+ +E + E   EE       E P          
Sbjct: 302 RPGRAPPAASARPSRSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVPESDRPAGAQH 361

Query: 945 -------GPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLK 989
                  GP      V   TP        +E  GP  G  TRQ +   A  K
Sbjct: 362 HQLNGERGPQSAKERVKEWTPC-GPHQGQDEGRGPAPGSGTRQVFSMAAMNK 412



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 3/91 (3%)

Query: 503 EGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEV 562
           EG+  P SDRP  A  +  + E   + +   V E + P  P +G  +    +P +   +V
Sbjct: 346 EGSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWT-PCGPHQGQDEGRGPAPGSGTRQV 404

Query: 563 KMTSFAERKKQLVKAEAEAGAGSPTSTPAPP 593
              S A   K+   A    G  SP+  P PP
Sbjct: 405 --FSMAAMNKEGGTASVATGPDSPSPVPLPP 433


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,832,124
Number of Sequences: 37866
Number of extensions: 3824592
Number of successful extensions: 39436
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 286
Number of HSP's successfully gapped in prelim test: 1785
Number of HSP's that attempted gapping in prelim test: 22595
Number of HSP's gapped (non-prelim): 13569
length of query: 1249
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1135
effective length of database: 13,930,794
effective search space: 15811451190
effective search space used: 15811451190
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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