Search of human proteins with 4504919

Search of human proteins with 4504919

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504919 keratin 8 [Homo sapiens]
         (483 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504919 keratin 8 [Homo sapiens]                                   918   0.0  
gi|119395754 keratin 5 [Homo sapiens]                                 526   e-149
gi|5031839 keratin 6A [Homo sapiens]                                  523   e-148
gi|153791158 keratin 75 [Homo sapiens]                                522   e-148
gi|155969697 keratin 6C [Homo sapiens]                                521   e-148
gi|119703753 keratin 6B [Homo sapiens]                                519   e-147
gi|67782365 keratin 7 [Homo sapiens]                                  509   e-144
gi|109148552 keratin 3 [Homo sapiens]                                 503   e-142
gi|109255249 keratin 4 [Homo sapiens]                                 490   e-138
gi|153791670 keratin 76 [Homo sapiens]                                477   e-135
gi|119395750 keratin 1 [Homo sapiens]                                 473   e-133
gi|28372503 keratin 72 isoform 1 [Homo sapiens]                       463   e-130
gi|226246663 keratin 72 isoform 1 [Homo sapiens]                      463   e-130
gi|28173564 keratin 73 [Homo sapiens]                                 463   e-130
gi|32567786 keratin 6L [Homo sapiens]                                 460   e-129
gi|15431316 keratin, hair, basic, 4 [Homo sapiens]                    457   e-129
gi|47132620 keratin 2 [Homo sapiens]                                  454   e-127
gi|15618995 keratin 71 [Homo sapiens]                                 446   e-125
gi|194018511 keratin 77 [Homo sapiens]                                442   e-124
gi|148612803 keratin 6 irs4 [Homo sapiens]                            439   e-123
gi|4504935 keratin 85 [Homo sapiens]                                  429   e-120
gi|27477127 keratin 82 [Homo sapiens]                                 419   e-117
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap...   415   e-116
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap...   415   e-116
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap...   415   e-116
gi|14318422 keratin 86 [Homo sapiens]                                 415   e-116
gi|89357932 keratin 5b [Homo sapiens]                                 413   e-115
gi|169790841 keratin 83 [Homo sapiens]                                411   e-115
gi|169790853 keratin, hair, basic, 1 [Homo sapiens]                   410   e-114
gi|226246665 keratin 72 isoform 2 [Homo sapiens]                      397   e-110

>gi|4504919 keratin 8 [Homo sapiens]
          Length = 483

 Score =  918 bits (2372), Expect = 0.0
 Identities = 483/483 (100%), Positives = 483/483 (100%)

Query: 1   MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM 60
           MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM
Sbjct: 1   MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM 60

Query: 61  GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLE 120
           GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLE
Sbjct: 61  GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLE 120

Query: 121 TKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYE 180
           TKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYE
Sbjct: 121 TKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYE 180

Query: 181 DEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQIS 240
           DEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQIS
Sbjct: 181 DEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQIS 240

Query: 241 DTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDL 300
           DTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDL
Sbjct: 241 DTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDL 300

Query: 301 RRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAAL 360
           RRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAAL
Sbjct: 301 RRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAAL 360

Query: 361 QRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYA 420
           QRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYA
Sbjct: 361 QRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYA 420

Query: 421 GGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDV 480
           GGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDV
Sbjct: 421 GGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDV 480

Query: 481 LPK 483
           LPK
Sbjct: 481 LPK 483


>gi|119395754 keratin 5 [Homo sapiens]
          Length = 590

 Score =  526 bits (1354), Expect = e-149
 Identities = 289/471 (61%), Positives = 351/471 (74%), Gaps = 27/471 (5%)

Query: 8   KSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYG--GASGMGG--- 62
           K   +STSG    +     +G G      + S  G   F GG GGG+G  G +G GG   
Sbjct: 72  KRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFG---FGGGAGGGFGLGGGAGFGGGFG 128

Query: 63  -----------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRF 111
                      I  VTVNQSLL+PL L++DP+IQ VRT+E+EQIKTLNNKFASFIDKVRF
Sbjct: 129 GPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRF 188

Query: 112 LEQQNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQ 169
           LEQQNK+L+TKW+LLQ+Q  KT R N++ +FE YINNLRRQL+++  E+ +L++EL NMQ
Sbjct: 189 LEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQ 248

Query: 170 GLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYE 229
            LVEDFKNKYEDEINKRT  ENEFV++KKDVD AYMNKVELE++++ L DEINF++  ++
Sbjct: 249 DLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFD 308

Query: 230 EEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEEL 289
            E+ ++Q+ +SDTSVVLSMDN+R+LD+DSIIAEVKAQYE+IANRSR EAES YQ KYEEL
Sbjct: 309 AELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEEL 368

Query: 290 QSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDA 349
           Q  AG+HGDDLR TK EISEMNR I RL+AEI+ +K Q A+L+ AIADAEQRGELA+KDA
Sbjct: 369 QQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDA 428

Query: 350 NAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES---GM 406
             KL+ELE ALQ+AKQDMAR LREYQELMN KLALD+EIATYRKLLEGEE RL     G 
Sbjct: 429 RNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGP 488

Query: 407 QNMSIHTKT-TSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTS 456
            N+S+ T + +SGY  G  S YGG    GL   LG     G+  S +S +S
Sbjct: 489 VNISVVTSSVSSGYGSG--SGYGGGLGGGLGGGLGGGLAGGSSGSYYSSSS 537



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 25/61 (40%), Positives = 32/61 (52%), Gaps = 10/61 (16%)

Query: 7  QKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYG-----GASGMG 61
          Q S    + G R+FS+ S  +   SR S +S SR G     GG GGG+G     GA G+G
Sbjct: 4  QSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSG-----GGGGGGFGRVSLAGACGVG 58

Query: 62 G 62
          G
Sbjct: 59 G 59


>gi|5031839 keratin 6A [Homo sapiens]
          Length = 564

 Score =  523 bits (1346), Expect = e-148
 Identities = 293/473 (61%), Positives = 347/473 (73%), Gaps = 24/473 (5%)

Query: 9   SYKVSTSGPRAFSSRSYTSGPGSRI----SSSSFSRVGSSNFRGGLGGGYGGASGMGG-- 62
           S ++S  G     S  Y S  G       + S F   G +    GLGGG G A G GG  
Sbjct: 67  SKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPG 126

Query: 63  --------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQ 114
                   I  VTVNQSLL+PL L++DP IQ VR +E+EQIKTLNNKFASFIDKVRFLEQ
Sbjct: 127 FPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQ 186

Query: 115 QNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLV 172
           QNK+LETKW+LLQ+Q  KT R N++ +FE YINNLRRQL+++  E+ +L++EL  MQ LV
Sbjct: 187 QNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLV 246

Query: 173 EDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEI 232
           EDFKNKYEDEINKRT  ENEFV +KKDVD AYMNKVEL+++ + LTDEINFLR LY+ E+
Sbjct: 247 EDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAEL 306

Query: 233 RELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSL 292
            ++Q+ ISDTSVVLSMDN+R+LD+DSIIAEVKAQYE+IA RSRAEAES YQ KYEELQ  
Sbjct: 307 SQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVT 366

Query: 293 AGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAK 352
           AG+HGDDLR TK EI+E+NR I RL++EI+ +K Q A+L+AAIADAEQRGE+A+KDA  K
Sbjct: 367 AGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNK 426

Query: 353 LSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES---GMQNM 409
           L  LE ALQ+AKQD+AR L+EYQELMNVKLALD+EIATYRKLLEGEE RL     G  N+
Sbjct: 427 LEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNI 486

Query: 410 SIHTKTTSGYAGGLSSAYGGL-TSPGLSYSLGSSFGSGAGSSSFSRTSSSRAV 461
           S+   T S   GG S    GL    G SYS GS  G G G SS    SS RA+
Sbjct: 487 SVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSS----SSGRAI 535



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 26/72 (36%), Positives = 35/72 (48%), Gaps = 12/72 (16%)

Query: 6  TQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRG--GLGGGYGGAS----- 58
          T  + +  +S  R FS+ S    PG  +S S FS V  S  RG  GLGG  GGA      
Sbjct: 4  TSTTIRSHSSSRRGFSANSARL-PG--VSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRS 60

Query: 59 --GMGGITAVTV 68
            G+GG   +++
Sbjct: 61 LYGLGGSKRISI 72


>gi|153791158 keratin 75 [Homo sapiens]
          Length = 551

 Score =  522 bits (1344), Expect = e-148
 Identities = 287/449 (63%), Positives = 345/449 (76%), Gaps = 16/449 (3%)

Query: 24  SYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGAS----GMGGITAVTVNQSLLSPLVLE 79
           S  SG G R +S+ F       + GG+GGG+ G S      GGI  VTVNQSLL+PL L+
Sbjct: 79  SCRSGFGGR-ASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQ 137

Query: 80  VDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQ--KTARSNMD 137
           +DP IQ VR +E+EQIKTLNNKFASFIDKVRFLEQQNK+LETKW+LLQ+Q  +T R N++
Sbjct: 138 IDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLE 197

Query: 138 NMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIK 197
            +F+SY + LRRQLE++  E+ +LEAEL NMQ +VEDFK +YEDEINKRT  ENEFV +K
Sbjct: 198 PLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALK 257

Query: 198 KDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMD 257
           KDVD AYMNKVELE++++ L +EINF+  +++ E+ +LQ+Q+ DTSVVLSMDN+R+LD+D
Sbjct: 258 KDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLD 317

Query: 258 SIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRL 317
           SIIAEVKAQYEDIANRSRAEAES YQ KYEELQ  AG+HGDDLR TK EISEMNR I RL
Sbjct: 318 SIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRL 377

Query: 318 QAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQEL 377
           +AEI+ +K Q +SL+ AIADAEQRGELA+KDA AKL +LE ALQ+AKQDMAR LREYQEL
Sbjct: 378 RAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQEL 437

Query: 378 MNVKLALDIEIATYRKLLEGEESRLES---GMQNMSIHTKT-TSGYAGGLSSAYGGL-TS 432
           MN+KLALD+EIATYRKLLEGEE RL        N+S+ T T +SGY  G S   G L   
Sbjct: 438 MNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLG 497

Query: 433 PGLSYSL----GSSFGSGAGSSSFSRTSS 457
            G  YS     G S G+G G S FS TS+
Sbjct: 498 GGSGYSFTTSGGHSLGAGLGGSGFSATSN 526


>gi|155969697 keratin 6C [Homo sapiens]
          Length = 564

 Score =  521 bits (1343), Expect = e-148
 Identities = 293/473 (61%), Positives = 347/473 (73%), Gaps = 24/473 (5%)

Query: 9   SYKVSTSGPRAFSSRSYTSGPGSRI----SSSSFSRVGSSNFRGGLGGGYGGASGMGG-- 62
           S ++S  G     S  Y S  G       + S F   G +    GLGGG G A G GG  
Sbjct: 67  SKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPG 126

Query: 63  --------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQ 114
                   I  VTVNQSLL+PL L++DP IQ VR +E+EQIKTLNNKFASFIDKVRFLEQ
Sbjct: 127 FPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQ 186

Query: 115 QNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLV 172
           QNK+L+TKW+LLQ+Q  KT R N++ +FE YINNLRRQL+++  E+ +L++EL NMQ LV
Sbjct: 187 QNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLV 246

Query: 173 EDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEI 232
           ED KNKYEDEINKRT  ENEFV +KKDVD AYMNKVEL+++ + LTDEINFLR LY+ E+
Sbjct: 247 EDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAEL 306

Query: 233 RELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSL 292
            ++Q+ ISDTSVVLSMDN+R+LD+DSIIAEVKAQYE+IA RSRAEAES YQ KYEELQ  
Sbjct: 307 SQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVT 366

Query: 293 AGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAK 352
           AG+HGDDLR TK EI+E+NR I RL++EI+ +K Q ASL+AAIADAEQRGE+A+KDA  K
Sbjct: 367 AGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNK 426

Query: 353 LSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES---GMQNM 409
           L  LE ALQ+AKQD+AR L+EYQELMNVKLALD+EIATYRKLLEGEE RL     G  N+
Sbjct: 427 LEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNV 486

Query: 410 SIHTKTTSGYAGGLSSAYGGL-TSPGLSYSLGSSFGSGAGSSSFSRTSSSRAV 461
           S+   T S   GG S    GL    G SYS GS  G G G SS    SS RA+
Sbjct: 487 SVVQSTISSGYGGASGVGSGLGLGGGSSYSYGSGLGIGGGFSS----SSGRAI 535



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 12/72 (16%)

Query: 6  TQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRG--GLGGGYGGAS----- 58
          T  + +  +S  R FS+ S    PG  +S S FS +  S  RG  GLGG  GGA      
Sbjct: 4  TSTTIRSHSSSRRGFSANSARL-PG--VSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS 60

Query: 59 --GMGGITAVTV 68
            G+GG   +++
Sbjct: 61 LYGLGGSKRISI 72


>gi|119703753 keratin 6B [Homo sapiens]
          Length = 564

 Score =  519 bits (1337), Expect = e-147
 Identities = 289/465 (62%), Positives = 342/465 (73%), Gaps = 20/465 (4%)

Query: 9   SYKVSTSGPRAFSSRSYTSGPGSRI----SSSSFSRVGSSNFRGGLGGGYGGASGMGG-- 62
           S ++S  G     S  Y S  G       + S F   G +    GLGGG G A G GG  
Sbjct: 67  SKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPG 126

Query: 63  --------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQ 114
                   I  VTVNQSLL+PL L++DP IQ VR +E+EQIKTLNNKFASFIDKVRFLEQ
Sbjct: 127 FPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQ 186

Query: 115 QNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLV 172
           QNK+L+TKW+LLQ+Q  KT R N++ +FE YINNLRRQL+ +  E+ +L++EL NMQ LV
Sbjct: 187 QNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLV 246

Query: 173 EDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEI 232
           ED KNKYEDEINKRT  ENEFV +KKDVD AYMNKVEL+++ + LTDEINFLR LY+ E+
Sbjct: 247 EDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAEL 306

Query: 233 RELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSL 292
            ++Q+ ISDTSVVLSMDN+R+LD+DSIIAEVKAQYE+IA RSRAEAES YQ KYEELQ  
Sbjct: 307 SQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQIT 366

Query: 293 AGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAK 352
           AG+HGDDLR TK EI+E+NR I RL++EI+ +K Q A+L+AAIADAEQRGE+A+KDA  K
Sbjct: 367 AGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNK 426

Query: 353 LSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES---GMQNM 409
           L  LE ALQ+AKQD+AR L+EYQELMNVKLALD+EIATYRKLLEGEE RL     G  N+
Sbjct: 427 LEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNI 486

Query: 410 SIHTKTTSGYAGGLSSAYGGL-TSPGLSYSLGSSFGSGAGSSSFS 453
           S+   T S   GG S    GL    G SYS GS  G G G SS S
Sbjct: 487 SVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSS 531



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 12/72 (16%)

Query: 6  TQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRG--GLGGGYGGAS----- 58
          T  + +  +S  R FS+ S    PG  +S S FS +  S  RG  GLGG  GGA      
Sbjct: 4  TSTTIRSHSSSRRGFSANSARL-PG--VSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS 60

Query: 59 --GMGGITAVTV 68
            G+GG   +++
Sbjct: 61 LYGLGGSKRISI 72


>gi|67782365 keratin 7 [Homo sapiens]
          Length = 469

 Score =  509 bits (1310), Expect = e-144
 Identities = 292/450 (64%), Positives = 341/450 (75%), Gaps = 17/450 (3%)

Query: 9   SYKVSTSGPRAFSSRSY-----TSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGI 63
           S  V TS   AFS R       ++ PG  + SSS   +G+S  R  +   YGG  G  GI
Sbjct: 6   SSPVFTSRSAAFSGRGAQVRLSSARPGG-LGSSSLYGLGASRPRVAVRSAYGGPVG-AGI 63

Query: 64  TAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKW 123
             VT+NQSLL+PL L+ DP++Q VR +E EQIKTLNNKFASFIDKVRFLEQQNK+LETKW
Sbjct: 64  REVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKW 123

Query: 124 SLLQQQKTARSN-MDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDE 182
           +LLQ+QK+A+S+ + ++FE+ I  LR QLE L  +  +LEAEL +MQ +VEDFKNKYEDE
Sbjct: 124 TLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDE 183

Query: 183 INKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDT 242
           IN RT  ENEFV++KKDVD AYM+KVELE++++ L DEINFLR L E E+ ELQSQISDT
Sbjct: 184 INHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDT 243

Query: 243 SVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRR 302
           SVVLSMDNSRSLD+D IIAEVKAQYE++A  SRAEAE+ YQ K+E LQ+ AGKHGDDLR 
Sbjct: 244 SVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRN 303

Query: 303 TKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQR 362
           T+ EISEMNR I RLQAEI+ +K QRA LEAAIA+AE+RGELA+KDA AK  ELEAALQR
Sbjct: 304 TRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQR 363

Query: 363 AKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES---GMQNMSIHTKTTSGY 419
            KQDMARQLREYQELM+VKLALDIEIATYRKLLEGEESRL     G  N+S+   T    
Sbjct: 364 GKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNST---- 419

Query: 420 AGGLSSAYG-GLTSPGLSYSLGSSFGSGAG 448
            GG SS  G GLT  G   S   SF S AG
Sbjct: 420 -GGSSSGGGIGLTLGGTMGSNALSFSSSAG 448


>gi|109148552 keratin 3 [Homo sapiens]
          Length = 628

 Score =  503 bits (1295), Expect = e-142
 Identities = 270/444 (60%), Positives = 331/444 (74%), Gaps = 16/444 (3%)

Query: 16  GPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSP 75
           G   F       GPG    S  F   GS     G  GG+G     GGI  VT+NQSLL P
Sbjct: 127 GAGGFGGAGGFGGPGGFGGSGGFGGPGSL----GSPGGFGPGGFPGGIQEVTINQSLLQP 182

Query: 76  LVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTAR-- 133
           L +E+DP I  V+ QE+EQIKTLNNKFASFIDKVRFLEQQNK+LETKW+LLQQQ T+   
Sbjct: 183 LNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSIS 242

Query: 134 --SNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMEN 191
             +N++ +FE++IN LR  L+ +  E+ +L++EL NM+ LVEDFK KYEDEINKRT  EN
Sbjct: 243 GTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAEN 302

Query: 192 EFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNS 251
           EFV +KKDVD AYMNKVEL+++++ L DEI+FLR LY+ E+ ++QS ISDTSVVLSMDN+
Sbjct: 303 EFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMDNN 362

Query: 252 RSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMN 311
           RSLD+DSIIAEV+AQYEDIA RS+AEAE++YQ K  ELQ+ AG+HGDDLR TK+EI E+N
Sbjct: 363 RSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELN 422

Query: 312 RNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQL 371
           R I RL+AEIEG+K Q A+L+ AIA+AEQ GE+A+KDANAKL EL+AALQ+AK D+AR L
Sbjct: 423 RMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLL 482

Query: 372 REYQELMNVKLALDIEIATYRKLLEGEESRLE----SGMQNMSIHTKTTSGYAGGLSSAY 427
           R+YQELMNVKLALD+EIATYRKLLEGEE R+     S +    + + TTS  AGG    Y
Sbjct: 483 RDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGGGY 542

Query: 428 GGLTSPGLSYSLGSSFGSGAGSSS 451
           GG    G+   LG  F +G GS S
Sbjct: 543 GG----GMGGGLGGGFSAGGGSGS 562



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 22/59 (37%), Positives = 30/59 (50%), Gaps = 9/59 (15%)

Query: 5  VTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGG-YGGASGMGG 62
          +++++ K S  G + FS RS      SR+S  + S        GG GGG YG  SG GG
Sbjct: 1  MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHS--------GGAGGGAYGFRSGAGG 51



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 16/43 (37%), Positives = 22/43 (51%), Gaps = 3/43 (6%)

Query: 25  YTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVT 67
           +++G GS    S F R G     GG GGG  G SG  G  +++
Sbjct: 554 FSAGGGS---GSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSIS 593



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 1/65 (1%)

Query: 1   MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM 60
           +++ V   +Y+    G     S    S     + SSS +   +  + GG GGG GG  G 
Sbjct: 493 LALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGGGYGGGMGGGLG- 551

Query: 61  GGITA 65
           GG +A
Sbjct: 552 GGFSA 556


>gi|109255249 keratin 4 [Homo sapiens]
          Length = 594

 Score =  490 bits (1261), Expect = e-138
 Identities = 258/439 (58%), Positives = 337/439 (76%), Gaps = 11/439 (2%)

Query: 42  GSSNFRGGLGGGYGGASG-------MGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQ 94
           G+  F GG GG + G  G        GGI  VT+NQSLL+PL +E+DP IQ VRT+E+EQ
Sbjct: 155 GTGGFGGGFGGSFSGKGGPGFPVCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQ 214

Query: 95  IKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARS--NMDNMFESYINNLRRQLE 152
           IK LNNKFASFIDKV+FLEQQNK+LETKW+LLQQQ T  S  N++ +FE+Y++ LR+QL+
Sbjct: 215 IKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLD 274

Query: 153 TLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELES 212
           TLG +K +L++EL  MQ  VEDFK KYE+EINKRT  EN+FV++KKDVD AY+NKVELE+
Sbjct: 275 TLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELEA 334

Query: 213 RLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIAN 272
           +++ L DEINFL+ LY+ E+ ++Q+ +SDTSVVLSMDN+R+LD+DSIIAEV+AQYE+IA 
Sbjct: 335 KVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQ 394

Query: 273 RSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLE 332
           RS+AEAE++YQ K ++LQ    +HGD+L+ TK+EI+E+NR I RL+AEIE +K Q  +L+
Sbjct: 395 RSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQ 454

Query: 333 AAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYR 392
            ++ADAEQRGE A+KDA++K  ELEAALQ+AK+++AR LREYQELM+VKLALDIEIATYR
Sbjct: 455 VSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYR 514

Query: 393 KLLEGEESRLESGMQN-MSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAG-SS 450
           KLLEGEE R+    Q+ +SI   + S   GG+S   G  +  GLS   GS  GSG G   
Sbjct: 515 KLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGG 574

Query: 451 SFSRTSSSRAVVVKKIETR 469
           S S +SSS+ +    +  R
Sbjct: 575 SVSGSSSSKIISTTTLNKR 593


>gi|153791670 keratin 76 [Homo sapiens]
          Length = 638

 Score =  477 bits (1228), Expect = e-135
 Identities = 264/448 (58%), Positives = 326/448 (72%), Gaps = 23/448 (5%)

Query: 24  SYTSG-PGSRISSSSFSRVGSSNFRGGLGG--------GYGGASGMG------GITAVTV 68
           SY  G  G R   S F   G     GG GG         +GG  G G      GI  V V
Sbjct: 101 SYGGGFGGGRGVGSGFGGAGGFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIV 160

Query: 69  NQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQ 128
           NQSLL PL +E+DP I  V+ QE+EQIKTLNNKFASFIDKVRFLEQQNK+LETKW LLQQ
Sbjct: 161 NQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQ 220

Query: 129 QKTAR--SNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKR 186
           Q T    S+++  FESYI+ L +QL++L  E+  LE EL +MQ LVEDFK KYEDEINKR
Sbjct: 221 QTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKR 280

Query: 187 TEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVL 246
           T  ENEFV +KKDVD A+MNKVEL+++++ LTDE++FLR LYE E+ ++QS  SDTSVVL
Sbjct: 281 TAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVL 340

Query: 247 SMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTE 306
           SMDN+R LD+ SIIAEV+AQYE+IA RS++EAE++YQ K  ELQ+ AG+HGDDLR TK+E
Sbjct: 341 SMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSE 400

Query: 307 ISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQD 366
           I E+NR I RL+AEIE +K Q A+L+ AIA+AEQRGE+A+KDANAKL +L+ ALQ+AK D
Sbjct: 401 IMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDD 460

Query: 367 MARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQ-----NMSIHTKTTSGYAG 421
           +AR LR+YQELMNVKLALD+EIATYRKLLEGEE R+    Q     ++  +  +TSG +G
Sbjct: 461 LARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSG 520

Query: 422 GLSSAYGGLTSPGL-SYSLGSSFGSGAG 448
                +GG++  G   Y  GSS  S +G
Sbjct: 521 SSRGVFGGVSGSGSGGYKGGSSSSSSSG 548



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 5/66 (7%)

Query: 14  TSGPRAFSSRSYTSGPGSRIS-----SSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTV 68
           ++G R  S    +S  GSR+      S S S +GSS+      GG G  SG GG T++  
Sbjct: 566 STGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRF 625

Query: 69  NQSLLS 74
           +Q+  S
Sbjct: 626 SQTTSS 631


>gi|119395750 keratin 1 [Homo sapiens]
          Length = 644

 Score =  473 bits (1218), Expect = e-133
 Identities = 248/408 (60%), Positives = 320/408 (78%), Gaps = 7/408 (1%)

Query: 48  GGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFID 107
           GG GGGYG     GGI  VT+NQSLL PL +E+DP IQ V+++E+EQIK+LNN+FASFID
Sbjct: 137 GGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFID 196

Query: 108 KVRFLEQQNKMLETKWSLLQQQKTARS--NMDNMFESYINNLRRQLETLGQEKLKLEAEL 165
           KVRFLEQQN++L+TKW LLQQ  T+    N++  FES+INNLRR+++ L  ++ +L++EL
Sbjct: 197 KVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSEL 256

Query: 166 GNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLR 225
            NMQ +VED++NKYEDEINKRT  ENEFV IKKDVD AYM KV+L+++L+ L  EI+FL 
Sbjct: 257 KNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLT 316

Query: 226 QLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIK 285
            LY+ E+ ++Q+QIS+T+V+LSMDN+RSLD+DSIIAEVKAQYEDIA +S+AEAES+YQ K
Sbjct: 317 ALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSK 376

Query: 286 YEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELA 345
           YEELQ  AG+HGD +R +K EISE+NR I RL++EI+ +K Q ++L+ +I+DAEQRGE A
Sbjct: 377 YEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENA 436

Query: 346 IKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESG 405
           +KDA  KL++LE ALQ+AK+D+AR LR+YQELMN KLALD+EIATYR LLEGEESR+   
Sbjct: 437 LKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGE 496

Query: 406 -MQNMSIH---TKTTSGYAGGLSSAYGGLTSPGLSY-SLGSSFGSGAG 448
              N+S+    + TT    G      GG  S G SY S G S+GSG G
Sbjct: 497 CAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGG 544



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 19/39 (48%), Positives = 21/39 (53%)

Query: 24  SYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG 62
           SY SG G     S  S   S  +RGG GGG GG+SG  G
Sbjct: 565 SYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRG 603



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 6/62 (9%)

Query: 1   MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM 60
           +S+ V+     +S  G R      Y SG       SS+   G S   GG GGG  G+ G 
Sbjct: 501 VSVSVSTSHTTISGGGSRGGGGGGYGSG------GSSYGSGGGSYGSGGGGGGGRGSYGS 554

Query: 61  GG 62
           GG
Sbjct: 555 GG 556



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 26/71 (36%), Positives = 30/71 (42%), Gaps = 17/71 (23%)

Query: 18 RAFSSRS-YTSGPG------------SRISSSSFSRVGSSNFR----GGLGGGYGGASGM 60
          R FSSRS Y SG G             R +SSS  R G    R    GG GG +G   G 
Sbjct: 3  RQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGF 62

Query: 61 GGITAVTVNQS 71
          G  + V +  S
Sbjct: 63 GSRSLVNLGGS 73



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 24/56 (42%), Positives = 29/56 (51%), Gaps = 3/56 (5%)

Query: 415 TTSGYAGGLSSAYGGLTSPGLSYSLGSSFGS--GAGSSSFSRTSSSRAVVVKKIET 468
           ++ GY GG S   GG +S G     GSS GS  G GSSS    SS  +  VK + T
Sbjct: 583 SSGGYRGG-SGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVST 637


>gi|28372503 keratin 72 isoform 1 [Homo sapiens]
          Length = 511

 Score =  463 bits (1192), Expect = e-130
 Identities = 253/456 (55%), Positives = 332/456 (72%), Gaps = 16/456 (3%)

Query: 9   SYKVSTSGPRAFSSRSYTSGPGSR-ISSSSFSRVGSSNFRGGLGGGYGGAS--------- 58
           S++    G  +F S+S +   GSR ++ S+ +R G     G +G  +G A          
Sbjct: 33  SFRARVKGSASFGSKSLSCLGGSRSLALSAAARRGGGRLGGFVGTAFGSAGLGPKCPSVC 92

Query: 59  GMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKM 118
             GGI  VTVN+SLL+PL +E+DP IQ VR QE+EQIK LNNKFASFIDKVRFLEQQN++
Sbjct: 93  PPGGIPQVTVNKSLLAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQNQV 152

Query: 119 LETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFK 176
           LETKW+LLQQ      R N++ ++E YI+NL++QLE L  + ++L++EL NMQ LVED+K
Sbjct: 153 LETKWNLLQQLDLNNCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSELRNMQDLVEDYK 212

Query: 177 NKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQ 236
            +YE EIN+RT  ENEFV++KKDVD AYMNKVEL+++++ LTDEI F + LYE EI ++Q
Sbjct: 213 KRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEITQIQ 272

Query: 237 SQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKH 296
           S ISDTS+VLSMDN+R LD+DSIIAEV+AQYE+IA +S+AEAE++YQ K +ELQ  AG+H
Sbjct: 273 SHISDTSIVLSMDNNRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKIQELQVTAGQH 332

Query: 297 GDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSEL 356
           GDDL+ TK EISE+NR I R+++EI  +K Q A LE AIADAEQRG+ A+KDA AKL EL
Sbjct: 333 GDDLKLTKAEISELNRLIQRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARAKLDEL 392

Query: 357 EAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN---MSIHT 413
           E AL +AK+++AR LREYQEL+++KLALD+EIATYRKLLE EE R+     N   +S+ +
Sbjct: 393 EGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVIS 452

Query: 414 KTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGS 449
            T +G AGG   + G   S   SY   ++     GS
Sbjct: 453 STNAG-AGGAGFSMGFGASSSYSYKTAAADVKTKGS 487


>gi|226246663 keratin 72 isoform 1 [Homo sapiens]
          Length = 511

 Score =  463 bits (1192), Expect = e-130
 Identities = 253/456 (55%), Positives = 332/456 (72%), Gaps = 16/456 (3%)

Query: 9   SYKVSTSGPRAFSSRSYTSGPGSR-ISSSSFSRVGSSNFRGGLGGGYGGAS--------- 58
           S++    G  +F S+S +   GSR ++ S+ +R G     G +G  +G A          
Sbjct: 33  SFRARVKGSASFGSKSLSCLGGSRSLALSAAARRGGGRLGGFVGTAFGSAGLGPKCPSVC 92

Query: 59  GMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKM 118
             GGI  VTVN+SLL+PL +E+DP IQ VR QE+EQIK LNNKFASFIDKVRFLEQQN++
Sbjct: 93  PPGGIPQVTVNKSLLAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQNQV 152

Query: 119 LETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFK 176
           LETKW+LLQQ      R N++ ++E YI+NL++QLE L  + ++L++EL NMQ LVED+K
Sbjct: 153 LETKWNLLQQLDLNNCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSELRNMQDLVEDYK 212

Query: 177 NKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQ 236
            +YE EIN+RT  ENEFV++KKDVD AYMNKVEL+++++ LTDEI F + LYE EI ++Q
Sbjct: 213 KRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEITQIQ 272

Query: 237 SQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKH 296
           S ISDTS+VLSMDN+R LD+DSIIAEV+AQYE+IA +S+AEAE++YQ K +ELQ  AG+H
Sbjct: 273 SHISDTSIVLSMDNNRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKIQELQVTAGQH 332

Query: 297 GDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSEL 356
           GDDL+ TK EISE+NR I R+++EI  +K Q A LE AIADAEQRG+ A+KDA AKL EL
Sbjct: 333 GDDLKLTKAEISELNRLIQRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARAKLDEL 392

Query: 357 EAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN---MSIHT 413
           E AL +AK+++AR LREYQEL+++KLALD+EIATYRKLLE EE R+     N   +S+ +
Sbjct: 393 EGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVIS 452

Query: 414 KTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGS 449
            T +G AGG   + G   S   SY   ++     GS
Sbjct: 453 STNAG-AGGAGFSMGFGASSSYSYKTAAADVKTKGS 487


>gi|28173564 keratin 73 [Homo sapiens]
          Length = 540

 Score =  463 bits (1191), Expect = e-130
 Identities = 269/511 (52%), Positives = 353/511 (69%), Gaps = 43/511 (8%)

Query: 6   TQKSYKVSTSG-PRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM---- 60
           +  SY+    G    FSSRS  S  G+R  S SF+    S + GG G G G ASG     
Sbjct: 28  SSSSYRAGGKGLSGGFSSRSLYSLGGAR--SISFNVASGSGWAGGYGFGRGRASGFAGSM 85

Query: 61  ----------------GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFAS 104
                           GGI  VT+N+SLL+PL +E+DP IQ VR QE+EQIK LNNKFAS
Sbjct: 86  FGSVALGSVCPSLCPPGGIHQVTINKSLLAPLNVELDPEIQKVRAQEREQIKVLNNKFAS 145

Query: 105 FIDKVRFLEQQNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLE 162
           FIDKVRFLEQQN++LETKW LLQQ      ++N++ + E YI+NLR+QLETL  ++++L+
Sbjct: 146 FIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLD 205

Query: 163 AELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEIN 222
           +EL +++ +VED+K +YE+EINKRT  ENEFV++KKDVD AY +KVEL+++++ L  EI 
Sbjct: 206 SELRSVREVVEDYKKRYEEEINKRTTAENEFVVLKKDVDAAYTSKVELQAKVDALDGEIK 265

Query: 223 FLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMY 282
           F + LYE E  ++QS ISDTS++LSMDN+R+LD+DSIIAEV+AQYE+IA +S+AEAE++Y
Sbjct: 266 FFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDSIIAEVRAQYEEIARKSKAEAEALY 325

Query: 283 QIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRG 342
           Q K++ELQ  AG+HGDDL+ TK EISE+ R I RL++EIE +K Q A+LE AIADAEQRG
Sbjct: 326 QTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLRSEIESVKKQCANLETAIADAEQRG 385

Query: 343 ELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRL 402
           + A+KDA AKL ELE ALQ+AK+++AR LREYQEL++VKL+LDIEIATYRKLLEGEE R+
Sbjct: 386 DCALKDARAKLDELEGALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRM 445

Query: 403 ESGMQN---MSIHTKTTSGYAG-----GLSSA--YG---GLTSPGLSYSLGSSFGSGAGS 449
                N   +S+   + +G AG     G S+A  YG      S G S   G   G   GS
Sbjct: 446 SGEYTNSVSISVINSSMAGMAGTGAGFGFSNAGTYGYWPSSVSGGYSMLPG---GCVTGS 502

Query: 450 SSFSRTSSSRAVVVKKIETRD--GKLVSESS 478
            + S    +R  +    E RD  GK ++ SS
Sbjct: 503 GNCSPRGEARTRLGSASEFRDSQGKTLALSS 533


>gi|32567786 keratin 6L [Homo sapiens]
          Length = 535

 Score =  460 bits (1183), Expect = e-129
 Identities = 254/457 (55%), Positives = 322/457 (70%), Gaps = 21/457 (4%)

Query: 16  GPRAFSSRS-YTSGPGSRISSSSFSRVGSSNFRGGLGGG-------------YGGASGMG 61
           G   F SRS Y  G    IS S           GG G G             +G A   G
Sbjct: 53  GTGGFGSRSLYNLGGHKSISVSVAGGALLGRALGGFGFGSRAFMGQGAGRQTFGPACPPG 112

Query: 62  GITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLET 121
           GI  VTVNQSLL+PL +E+DP IQ VRTQE+EQIKTLNNKFASFIDKVRFLEQQNK+LET
Sbjct: 113 GIQEVTVNQSLLTPLHVEIDPEIQRVRTQEREQIKTLNNKFASFIDKVRFLEQQNKVLET 172

Query: 122 KWSLLQQQK----TARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKN 177
           KW+LLQ+Q       R+N++ +FE+Y+ ++R  L+ L  E+ +L++EL N+Q LVEDFKN
Sbjct: 173 KWALLQEQGQNLGVTRNNLEPLFEAYLGSMRSTLDRLQSERGRLDSELRNVQDLVEDFKN 232

Query: 178 KYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQS 237
           KYEDEINK T  ENEFV++KKDVD AYM +++L  ++  LT EI+FL+QLYE E+ ++Q+
Sbjct: 233 KYEDEINKHTAAENEFVVLKKDVDAAYMGRMDLHGKVGTLTQEIDFLQQLYEMELSQVQT 292

Query: 238 QISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHG 297
            +S+T+VVLSMDN+R+LD+DSIIAEVKAQYE IA RSRAEAE+ YQ KYEELQ  AGKHG
Sbjct: 293 HVSNTNVVLSMDNNRNLDLDSIIAEVKAQYELIAQRSRAEAEAWYQTKYEELQVTAGKHG 352

Query: 298 DDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELE 357
           D+LR TK EI+E+ R I RLQ E +  K Q   L+ AIA+AEQRGELA+KDA  KL +L+
Sbjct: 353 DNLRDTKNEIAELTRTIQRLQGEADAAKKQCQQLQTAIAEAEQRGELALKDAQKKLGDLD 412

Query: 358 AALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES---GMQNMSIHTK 414
            AL +AK+D+ R LR+YQELMNVKLALD+EIATYRKLLE EESR+        ++S+   
Sbjct: 413 VALHQAKEDLTRLLRDYQELMNVKLALDVEIATYRKLLESEESRMSGECPSAVSISVTGN 472

Query: 415 TTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSS 451
           +T+   GG +S  GG++  G   +    F +  G S+
Sbjct: 473 STTVCGGGAASFGGGISLGGSGGATKGGFSTNVGYST 509


>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
          Length = 600

 Score =  457 bits (1176), Expect = e-129
 Identities = 257/449 (57%), Positives = 316/449 (70%), Gaps = 28/449 (6%)

Query: 16  GPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYG----GASGMGGITAVTVNQS 71
           GPRA S      G GS I              GG G GY     G      ITAVTVN+S
Sbjct: 96  GPRADSCVGLGFGAGSGIGYGF----------GGPGFGYRVGGVGVPAAPSITAVTVNKS 145

Query: 72  LLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKT 131
           LL+PL LE+DPN Q V+  EKEQIKTLNNKFASFIDKVRFLEQQNK+LETKWS LQ+QK 
Sbjct: 146 LLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKC 205

Query: 132 ARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMEN 191
            RSN++ +FESYI NLRRQLE L  ++ +L+AE  ++Q ++E FK KYE+E+  R   EN
Sbjct: 206 IRSNLEPLFESYITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAEN 265

Query: 192 EFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNS 251
           EFV +KKDVD A+MNK +LE+ ++ LT EI+FL+ LY EEI+ LQS IS+TSV++ MDNS
Sbjct: 266 EFVALKKDVDAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNS 325

Query: 252 RSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMN 311
           R L++D IIAEVKAQYE++A RSRA+AE+ YQ KYEE+Q  AG+H D+LR  + EI+E+ 
Sbjct: 326 RDLNLDGIIAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELT 385

Query: 312 RNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQL 371
           R I RL+AEIE  K QRA LEAA+A+AEQ+GE  + DA  KL++LE ALQ+AKQDMARQL
Sbjct: 386 RLIQRLKAEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQL 445

Query: 372 REYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLT 431
            EYQELMN KL LDIEIATYR+LLEGEESRL  G+  ++I           +SS+ GGL 
Sbjct: 446 CEYQELMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNI----------SVSSSRGGLV 495

Query: 432 SPGLSYSLGSSFGSG----AGSSSFSRTS 456
                   GS+   G    +GSSS   TS
Sbjct: 496 CGPEPLVAGSTLSRGGVTFSGSSSVCATS 524


>gi|47132620 keratin 2 [Homo sapiens]
          Length = 639

 Score =  454 bits (1167), Expect = e-127
 Identities = 252/453 (55%), Positives = 318/453 (70%), Gaps = 26/453 (5%)

Query: 28  GPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG---------------ITAVTVNQSL 72
           G GS  S   F   G   F GG  GG+GG  G+GG               I  V+VNQSL
Sbjct: 103 GGGSGFSGGGF---GGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSL 159

Query: 73  LSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQK-- 130
           L PL ++VDP IQ V+ QE+EQIKTLNNKFASFIDKVRFLEQQN++L+TKW LLQQ    
Sbjct: 160 LQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVG 219

Query: 131 TARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEME 190
           T   N++ +F+ YI++L+R L+ L  E+    +EL NMQ LVED+K KYEDEINKRT  E
Sbjct: 220 TRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAE 279

Query: 191 NEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDN 250
           N+FV +KKDVD AYM KVEL+S+++ L  EI FL+ LY+ EI ++   ++DT+V+LSMDN
Sbjct: 280 NDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDN 339

Query: 251 SRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEM 310
           SR+LD+DSIIAEVKAQYE+IA RS+ EAE++Y  KYEELQ   G+HGD L+  K EISE+
Sbjct: 340 SRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISEL 399

Query: 311 NRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQ 370
           NR I RLQ EI  +K Q  +++ AIADAEQRGE A+KDA  KL++LE ALQ+AK+D+AR 
Sbjct: 400 NRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARL 459

Query: 371 LREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSS--AYG 428
           LR+YQELMNVKLALD+EIATYRKLLEGEE R+   + +    + T+S  +  ++S  A+G
Sbjct: 460 LRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFG 519

Query: 429 GL----TSPGLSYSLGSSFGSGAGSSSFSRTSS 457
           G     +S G  YS GSS     G  S SR  S
Sbjct: 520 GSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGS 552



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 24/61 (39%), Positives = 33/61 (54%), Gaps = 10/61 (16%)

Query: 16 GPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGAS-------GMGGITAVTV 68
          G R FSS S     GSR S+SSFS +      GG GGG+GG         G+GG  ++++
Sbjct: 18 GFRGFSSGSAVVSGGSRRSTSSFSCLSR---HGGGGGGFGGGGFGSRSLVGLGGTKSISI 74

Query: 69 N 69
          +
Sbjct: 75 S 75



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 7/69 (10%)

Query: 1   MSIRVTQKSYKVSTSGPRAFSS---RSYTSGPGSRISSSSFSRVG-SSNFRGGLGGG--- 53
           +++ VT  +   + +   AF     R  +SG G    SSS+   G  S  RGG GGG   
Sbjct: 499 VTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSI 558

Query: 54  YGGASGMGG 62
            GG  G GG
Sbjct: 559 SGGGYGSGG 567



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 21/48 (43%), Positives = 23/48 (47%), Gaps = 1/48 (2%)

Query: 15  SGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG 62
           SG R   SR  + G GS IS   +   G S  R G GGG  G S  GG
Sbjct: 541 SGGRQSGSRGGSGGGGS-ISGGGYGSGGGSGGRYGSGGGSKGGSISGG 587



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 21/54 (38%), Positives = 28/54 (51%), Gaps = 2/54 (3%)

Query: 19  AFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSL 72
           + S   Y SG G + SS   SR GSS+  GG G G GG+S + G +      S+
Sbjct: 583 SISGGGYGSG-GGKHSSGGGSRGGSSS-GGGYGSGGGGSSSVKGSSGEAFGSSV 634


>gi|15618995 keratin 71 [Homo sapiens]
          Length = 523

 Score =  446 bits (1148), Expect = e-125
 Identities = 246/446 (55%), Positives = 319/446 (71%), Gaps = 30/446 (6%)

Query: 6   TQKSYKVSTSG-PRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM---- 60
           +  S++  + G    F SRS  S  G R    S +    S   GG G G G ASG     
Sbjct: 28  SSSSFRAGSKGLSGGFGSRSLYSLGGVR----SLNVASGSGKSGGYGFGRGRASGFAGSM 83

Query: 61  ----------------GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFAS 104
                           GGI  VTVN+SLL+PL +E+DP IQ VR QE+EQIK LNNKFAS
Sbjct: 84  FGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFAS 143

Query: 105 FIDKVRFLEQQNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLE 162
           FIDKVRFLEQQN++LETKW LLQQ      ++N++ + E YI+NLR+QLETL  ++++L+
Sbjct: 144 FIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLD 203

Query: 163 AELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEIN 222
           +EL N++ +VED+K +YE+EINKRT  ENEFVL+KKDVD AY NKVEL++++E +  EI 
Sbjct: 204 SELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIK 263

Query: 223 FLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMY 282
           F R L+E EI ++QS ISD SV+LSMDN+R+LD+DSII EV+ QYE+IA +S+AEAE++Y
Sbjct: 264 FFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALY 323

Query: 283 QIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRG 342
           Q K++ELQ  AG+HGDDL+ TK EISE+ R I R+++EIE +K Q ++LE AIADAEQRG
Sbjct: 324 QTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRG 383

Query: 343 ELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRL 402
           + A+KDA AKL ELE AL +AK+++AR LREYQELM++KLALD+EIATYRKLLE EE R+
Sbjct: 384 DNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRM 443

Query: 403 ESGMQNMSIHTKTTSGYAGGLSSAYG 428
            SG     +     S  +GG  S YG
Sbjct: 444 -SGEFPSPVSISIISSTSGG--SVYG 466


>gi|194018511 keratin 77 [Homo sapiens]
          Length = 578

 Score =  442 bits (1136), Expect = e-124
 Identities = 238/465 (51%), Positives = 323/465 (69%), Gaps = 29/465 (6%)

Query: 25  YTSGPGSRISSSSFSRVGSSNFRG-GLG------GGYGGASGMGGITAVTVNQSLLSPLV 77
           +  G G  + S+     G   F G G G      GG+G     GGI  VT+NQSLL PL 
Sbjct: 91  FGGGRGFGVGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLH 150

Query: 78  LEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTAR--SN 135
           LEVDP IQ ++TQE+EQI  LNNKFASFIDKVRFLEQQN++L+TKW LLQQ  T+   +N
Sbjct: 151 LEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNN 210

Query: 136 MDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVL 195
           ++ + E+YI +LRRQ++ L  E+++  AE+ +MQ +VED+K+KYEDEINKRT  EN+FV+
Sbjct: 211 LEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVV 270

Query: 196 IKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLD 255
           +KKDVD AY++KV+LESR++ LT E+NFL+ L+  E+ ++Q+ ISDT+V+LSMDN+RSLD
Sbjct: 271 LKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLD 330

Query: 256 MDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNIS 315
           +DSII  V+ QYE IA RS+ EAE++YQ KY+ELQ  AG+HGDDL+ +K EI+E+NR + 
Sbjct: 331 LDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQ 390

Query: 316 RLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQ 375
           RLQAEI  +K Q   +++ I+DAE+RGE A++DA  KL +LE ALQ++K+++AR LR+YQ
Sbjct: 391 RLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQ 450

Query: 376 ELMNVKLALDIEIATYRKLLEGEESRLESGMQ---NMSIHTKTTS--------------G 418
            ++ VKL+LD+EIATYR+LLEGEESR+   +Q   ++S+     S              G
Sbjct: 451 AMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGG 510

Query: 419 YAGGLSSAYGGLTS---PGLSYSLGSSFGSGAGSSSFSRTSSSRA 460
           Y GG    YGG  S    G     G  +GSG G    S   S R+
Sbjct: 511 YGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRS 555



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 2/62 (3%)

Query: 1   MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM 60
           +S++ +Q S      G  ++ S  Y  G G         R G +  RG  GGGYG   G 
Sbjct: 487 ISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGA--RGRSGGGYGSGCGG 544

Query: 61  GG 62
           GG
Sbjct: 545 GG 546


>gi|148612803 keratin 6 irs4 [Homo sapiens]
          Length = 529

 Score =  439 bits (1130), Expect = e-123
 Identities = 258/493 (52%), Positives = 337/493 (68%), Gaps = 43/493 (8%)

Query: 9   SYKVSTSGPRA-FSSRS-YTSGPGSRIS---SSSFSRVGSSNFRGGLGGGYGGASGM--- 60
           SY  +  G  A F SRS Y+ G   RIS   +    R G   FR G G G G ASG    
Sbjct: 33  SYCAAGRGAGAGFGSRSLYSLGGNRRISFNVAGGGVRAGGYGFRPGSGYGGGRASGFAGS 92

Query: 61  -----------------GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFA 103
                            GGI  VTVN+SLL+PL +E+DP IQ VR QE+EQIK LN+KFA
Sbjct: 93  MFGSVALGPACLSVCPPGGIHQVTVNKSLLAPLNVELDPEIQKVRAQEREQIKVLNDKFA 152

Query: 104 SFIDKVRFLEQQNKMLETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKL 161
           SFIDKVRFLEQQN++LETKW LLQQ      + N++ + E YI+NLR+QLETL  ++++L
Sbjct: 153 SFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYISNLRKQLETLSGDRVRL 212

Query: 162 EAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEI 221
           ++EL +M+ LVED+K +YE EIN+RT  ENEFV++KKD D AY  KVEL+++++ L  EI
Sbjct: 213 DSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVELQAKVDSLDKEI 272

Query: 222 NFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESM 281
            FL+ LY+ EI ++Q+  S+TSV+LSMDN+R LD+DSIIAEV+  YE+IA +S+AEAE++
Sbjct: 273 KFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEVRMHYEEIALKSKAEAEAL 332

Query: 282 YQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQR 341
           YQ K +ELQ  A +HGDDL+ T++E+ E+NR I R++ EI  +K QRASLE AIADAEQR
Sbjct: 333 YQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIADAEQR 392

Query: 342 GELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESR 401
           G+ A+KDA AKL ELE AL +AK+++AR LREYQELM++KLALD+EIATYRKLLEGEE R
Sbjct: 393 GDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEECR 452

Query: 402 LESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTS-SSRA 460
           + SG    S+     S      SS+Y        SY   SS G   G+S+ + +S S+++
Sbjct: 453 M-SGENPSSVSISVIS------SSSY--------SYHHPSSAGVDLGASAVAGSSGSTQS 497

Query: 461 VVVKKIETRDGKL 473
              K  E R G L
Sbjct: 498 GQTKTTEARGGDL 510


>gi|4504935 keratin 85 [Homo sapiens]
          Length = 507

 Score =  429 bits (1103), Expect = e-120
 Identities = 237/437 (54%), Positives = 312/437 (71%), Gaps = 20/437 (4%)

Query: 12  VSTSGPRAFSSRSYTSGPGSRISSSSFS---RVGSSNFRGGLGG---GY--GGASGMGG- 62
           +S +  R  S     +G GSR   +  S   R+    FR G  G   GY  GG  G    
Sbjct: 34  ISAAPYRGVSCYRGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPP 93

Query: 63  -ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLET 121
            IT V+VN+SLL+PL LE+DPN Q V+ +EKEQIK+LN++FA+FIDKVRFLEQQNK+LET
Sbjct: 94  CITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLET 153

Query: 122 KWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYED 181
           KW   Q Q+   SN++ +F  YI  LRR+ E +  +  +L +EL ++Q ++E +K KYE+
Sbjct: 154 KWQFYQNQRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEE 213

Query: 182 EINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISD 241
           E+  R   ENEFV++KKDVD AY+ K +LE+ +E L +E +FLR+LYEEEIR LQ+ ISD
Sbjct: 214 EVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISD 273

Query: 242 TSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLR 301
           TSV++ MDNSR L+MD IIAE+KAQY+D+A+RSRAEAES Y+ K EE+++   +HG+ LR
Sbjct: 274 TSVIVKMDNSRDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLR 333

Query: 302 RTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQ 361
           RTK EI+E+NR I RL AEIE  K QRA LEAA+A+AEQ+GE A+ DA  KL+ELE ALQ
Sbjct: 334 RTKEEINELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQ 393

Query: 362 RAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAG 421
           +AKQDMA  L+EYQE+MN KL LDIEIATYR+LLEGEE RL  G+ ++++          
Sbjct: 394 KAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNV---------- 443

Query: 422 GLSSAYGGLTSPGLSYS 438
            +SS+ GG++  GLSYS
Sbjct: 444 CVSSSRGGVSCGGLSYS 460


>gi|27477127 keratin 82 [Homo sapiens]
          Length = 513

 Score =  419 bits (1078), Expect = e-117
 Identities = 221/395 (55%), Positives = 293/395 (74%), Gaps = 6/395 (1%)

Query: 30  GSR-ISSSSFSRVGSSNFRGGLGGGYGGASGM-----GGITAVTVNQSLLSPLVLEVDPN 83
           GSR + +  F R   ++  GG   G+G   G        IT VT+N+SLL PL LE+DP 
Sbjct: 53  GSRSLCNVGFGRPRVASRCGGTLPGFGYRLGATCGPSACITPVTINESLLVPLALEIDPT 112

Query: 84  IQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESY 143
           +Q V+  EKEQIK LNN+FASFI+KVRFLEQ+NK+LETKW+ +QQQ+  ++N++ +FE Y
Sbjct: 113 VQRVKRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRCCQTNIEPIFEGY 172

Query: 144 INNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEA 203
           I+ LRRQL+ +  ++++LE+EL ++Q  +E +K KYE+E++ R  +ENEFV +KKDVD A
Sbjct: 173 ISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCVENEFVALKKDVDTA 232

Query: 204 YMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEV 263
           ++ K +LE+  E L  EI+FL+ LYEEEI  LQSQIS+TSV++ MDNSR LD+D IIAE+
Sbjct: 233 FLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNSRELDVDGIIAEI 292

Query: 264 KAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEG 323
           KAQY+DIA+RS+AEAE+ YQ +YEEL+  AG H D+LR  K EI EMN+ I RLQ E E 
Sbjct: 293 KAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQETEN 352

Query: 324 LKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLA 383
           +K QR  LE AIA+AEQ+GE A+ DA  KL+ LE ALQ+AKQDMA  L+EYQE+MN KL 
Sbjct: 353 VKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLG 412

Query: 384 LDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSG 418
           LDIEIATYR+LLEGEE RL  G+  ++I   ++ G
Sbjct: 413 LDIEIATYRRLLEGEEHRLCEGIGPVNISVSSSKG 447


>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
           sapiens]
          Length = 486

 Score =  415 bits (1067), Expect = e-116
 Identities = 227/430 (52%), Positives = 299/430 (69%), Gaps = 25/430 (5%)

Query: 13  STSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG---------- 62
           S  G RAFS  S       R   ++    G S +RG L GG+G  S  GG          
Sbjct: 5   SYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRG-LTGGFGSHSVCGGFRAGSCGRSF 63

Query: 63  --------------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDK 108
                         IT V+VN+SLL+PL LE+DPN Q V+ +EKEQIK+LN++FA+FIDK
Sbjct: 64  GYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDK 123

Query: 109 VRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNM 168
           VRFLEQQNK+LETK    Q ++  +SN++ +FE YI  LRR+ E +  +  +L +EL ++
Sbjct: 124 VRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHV 183

Query: 169 QGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLY 228
           Q ++E +K KYE+E++ R   ENEFV +KKDVD AY+ K +LE+ +E L  EI+FLR+LY
Sbjct: 184 QEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLY 243

Query: 229 EEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEE 288
           EEEIR LQS ISDTSVV+ +DNSR L+MD IIAE+KAQY+DI  RSRAEAES Y+ K EE
Sbjct: 244 EEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEE 303

Query: 289 LQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKD 348
           +++   +HG+ LRRTK EI+E+NR I RL AE+E  K Q + LEAA+A +EQ+GE A+ D
Sbjct: 304 MKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSD 363

Query: 349 ANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN 408
           A  KL+ELE ALQ+AKQDMA  +REYQE+MN KL LDIEIATYR+LLEGEE RL  G+ +
Sbjct: 364 ARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGS 423

Query: 409 MSIHTKTTSG 418
           +++   ++ G
Sbjct: 424 VNVCVSSSRG 433


>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
           sapiens]
          Length = 486

 Score =  415 bits (1067), Expect = e-116
 Identities = 227/430 (52%), Positives = 299/430 (69%), Gaps = 25/430 (5%)

Query: 13  STSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG---------- 62
           S  G RAFS  S       R   ++    G S +RG L GG+G  S  GG          
Sbjct: 5   SYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRG-LTGGFGSHSVCGGFRAGSCGRSF 63

Query: 63  --------------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDK 108
                         IT V+VN+SLL+PL LE+DPN Q V+ +EKEQIK+LN++FA+FIDK
Sbjct: 64  GYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDK 123

Query: 109 VRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNM 168
           VRFLEQQNK+LETK    Q ++  +SN++ +FE YI  LRR+ E +  +  +L +EL ++
Sbjct: 124 VRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHV 183

Query: 169 QGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLY 228
           Q ++E +K KYE+E++ R   ENEFV +KKDVD AY+ K +LE+ +E L  EI+FLR+LY
Sbjct: 184 QEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLY 243

Query: 229 EEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEE 288
           EEEIR LQS ISDTSVV+ +DNSR L+MD IIAE+KAQY+DI  RSRAEAES Y+ K EE
Sbjct: 244 EEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEE 303

Query: 289 LQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKD 348
           +++   +HG+ LRRTK EI+E+NR I RL AE+E  K Q + LEAA+A +EQ+GE A+ D
Sbjct: 304 MKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSD 363

Query: 349 ANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN 408
           A  KL+ELE ALQ+AKQDMA  +REYQE+MN KL LDIEIATYR+LLEGEE RL  G+ +
Sbjct: 364 ARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGS 423

Query: 409 MSIHTKTTSG 418
           +++   ++ G
Sbjct: 424 VNVCVSSSRG 433


>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
           sapiens]
          Length = 486

 Score =  415 bits (1067), Expect = e-116
 Identities = 227/430 (52%), Positives = 299/430 (69%), Gaps = 25/430 (5%)

Query: 13  STSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG---------- 62
           S  G RAFS  S       R   ++    G S +RG L GG+G  S  GG          
Sbjct: 5   SYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRG-LTGGFGSHSVCGGFRAGSCGRSF 63

Query: 63  --------------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDK 108
                         IT V+VN+SLL+PL LE+DPN Q V+ +EKEQIK+LN++FA+FIDK
Sbjct: 64  GYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDK 123

Query: 109 VRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNM 168
           VRFLEQQNK+LETK    Q ++  +SN++ +FE YI  LRR+ E +  +  +L +EL ++
Sbjct: 124 VRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHV 183

Query: 169 QGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLY 228
           Q ++E +K KYE+E++ R   ENEFV +KKDVD AY+ K +LE+ +E L  EI+FLR+LY
Sbjct: 184 QEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLY 243

Query: 229 EEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEE 288
           EEEIR LQS ISDTSVV+ +DNSR L+MD IIAE+KAQY+DI  RSRAEAES Y+ K EE
Sbjct: 244 EEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEE 303

Query: 289 LQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKD 348
           +++   +HG+ LRRTK EI+E+NR I RL AE+E  K Q + LEAA+A +EQ+GE A+ D
Sbjct: 304 MKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSD 363

Query: 349 ANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN 408
           A  KL+ELE ALQ+AKQDMA  +REYQE+MN KL LDIEIATYR+LLEGEE RL  G+ +
Sbjct: 364 ARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGS 423

Query: 409 MSIHTKTTSG 418
           +++   ++ G
Sbjct: 424 VNVCVSSSRG 433


>gi|14318422 keratin 86 [Homo sapiens]
          Length = 486

 Score =  415 bits (1067), Expect = e-116
 Identities = 227/430 (52%), Positives = 299/430 (69%), Gaps = 25/430 (5%)

Query: 13  STSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG---------- 62
           S  G RAFS  S       R   ++    G S +RG L GG+G  S  GG          
Sbjct: 5   SYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRG-LTGGFGSHSVCGGFRAGSCGRSF 63

Query: 63  --------------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDK 108
                         IT V+VN+SLL+PL LE+DPN Q V+ +EKEQIK+LN++FA+FIDK
Sbjct: 64  GYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDK 123

Query: 109 VRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNM 168
           VRFLEQQNK+LETK    Q ++  +SN++ +FE YI  LRR+ E +  +  +L +EL ++
Sbjct: 124 VRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHV 183

Query: 169 QGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLY 228
           Q ++E +K KYE+E++ R   ENEFV +KKDVD AY+ K +LE+ +E L  EI+FLR+LY
Sbjct: 184 QEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLY 243

Query: 229 EEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEE 288
           EEEIR LQS ISDTSVV+ +DNSR L+MD IIAE+KAQY+DI  RSRAEAES Y+ K EE
Sbjct: 244 EEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEE 303

Query: 289 LQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKD 348
           +++   +HG+ LRRTK EI+E+NR I RL AE+E  K Q + LEAA+A +EQ+GE A+ D
Sbjct: 304 MKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSD 363

Query: 349 ANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN 408
           A  KL+ELE ALQ+AKQDMA  +REYQE+MN KL LDIEIATYR+LLEGEE RL  G+ +
Sbjct: 364 ARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGS 423

Query: 409 MSIHTKTTSG 418
           +++   ++ G
Sbjct: 424 VNVCVSSSRG 433


>gi|89357932 keratin 5b [Homo sapiens]
          Length = 520

 Score =  413 bits (1062), Expect = e-115
 Identities = 231/439 (52%), Positives = 310/439 (70%), Gaps = 18/439 (4%)

Query: 20  FSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM-----GGITAVTVNQSLLS 74
           FSSRS  S  G  +  S  S  GS    G   G + G  G+     GGI  VT+NQ+LL+
Sbjct: 36  FSSRSLNSFGGC-LEGSRGSTWGSGGRLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLT 94

Query: 75  PLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARS 134
           PL +E+DP  Q VRTQE ++I+TLNN+FASFIDKVRFLEQQNK+LETKW LLQQQ  + S
Sbjct: 95  PLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGS 154

Query: 135 N--MDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENE 192
              ++ +FE+ ++ LR+QLE L  E+  L+AEL   +   E++K+KYE+E ++R  +EN+
Sbjct: 155 QQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLEND 214

Query: 193 FVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSR 252
           FV++KKDVD  +++K+ELE +LE L + + FL+ L EEE+ +LQ+Q SDTSVVLSMDN+R
Sbjct: 215 FVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNR 274

Query: 253 SLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNR 312
            LD  SII EV+A+YE+IA  S+AEAE++YQ KY+ELQ  A  HGD ++ TK +IS++++
Sbjct: 275 YLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQ 334

Query: 313 NISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLR 372
            I RLQ++ E LK Q ASL+AAI DAEQRGELA+KDA AK+ ELEAAL+ AKQ++AR L 
Sbjct: 335 EIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLC 394

Query: 373 EYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTS 432
           EYQEL + KL+LD+EIATYR+LLEGEE R+ SG     +   +  G A         + S
Sbjct: 395 EYQELTSTKLSLDVEIATYRRLLEGEECRM-SGECTSQVTISSVGGSA---------VMS 444

Query: 433 PGLSYSLGSSFGSGAGSSS 451
            G+   LGS+ G G+G  S
Sbjct: 445 GGVGGGLGSTCGLGSGKGS 463


>gi|169790841 keratin 83 [Homo sapiens]
          Length = 493

 Score =  411 bits (1056), Expect = e-115
 Identities = 218/396 (55%), Positives = 286/396 (72%), Gaps = 1/396 (0%)

Query: 23  RSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDP 82
           R  T G GS      F         G   GG  G S    IT V+VN+SLL+PL LE+DP
Sbjct: 44  RGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPC-ITTVSVNESLLTPLNLEIDP 102

Query: 83  NIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFES 142
           N Q V+ +EKEQIK+LN++FA+FIDKVRFLEQQNK+LETK    Q ++  +SN++ +F  
Sbjct: 103 NAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAG 162

Query: 143 YINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDE 202
           YI  LRR+ E +  +  +L +EL ++Q ++E +K KYE+E+  R   ENEFV +KKDVD 
Sbjct: 163 YIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDC 222

Query: 203 AYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAE 262
           AY+ K +LE+ +E L  EI+FLR+LYEEEIR LQS ISDTSVV+ +DNSR L+MD I+AE
Sbjct: 223 AYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIVAE 282

Query: 263 VKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIE 322
           +KAQY+DIA RSRAEAES Y+ K EE+++   +HG+ LRRTK EI+E+NR I RL AE+E
Sbjct: 283 IKAQYDDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVE 342

Query: 323 GLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKL 382
             K Q + LEAA+A +EQ+GE A+ DA  KL+ELE ALQ+AKQDMA  +REYQE+MN KL
Sbjct: 343 NAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKL 402

Query: 383 ALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSG 418
            LDIEIATYR+LLEGEE RL  G++ +++   ++ G
Sbjct: 403 GLDIEIATYRRLLEGEEQRLCEGVEAVNVCVSSSRG 438


>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
          Length = 505

 Score =  410 bits (1055), Expect = e-114
 Identities = 225/427 (52%), Positives = 296/427 (69%), Gaps = 25/427 (5%)

Query: 16  GPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGG------------- 62
           G RAFS  S       R   ++    G S +RG L GG+G  S  GG             
Sbjct: 8   GGRAFSCISACGPRPGRCCITAAPYRGISCYRG-LTGGFGSHSVCGGFRAGSCGRSFGYR 66

Query: 63  -----------ITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRF 111
                      IT V+VN+SLL+PL LE+DPN Q V+ +EKEQIK+LN++FA+FIDKVRF
Sbjct: 67  SGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRF 126

Query: 112 LEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGL 171
           LEQQNK+LETK    Q ++  +SN++ +FE YI  LRR+ E +  +  +L +EL ++Q +
Sbjct: 127 LEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEV 186

Query: 172 VEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEE 231
           +E +K KYE+E++ R   ENEFV +KKDVD AY+ K +LE+ +E L  EI+FLR+LYEEE
Sbjct: 187 LEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEE 246

Query: 232 IRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQS 291
           I  LQS ISDTSVV+ +DNSR L+MD IIAE+KAQY+DI  RSRAEAES Y+ K EE+++
Sbjct: 247 ILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKA 306

Query: 292 LAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANA 351
              +HG+ LRRTK EI+E+NR I RL AE+E  K Q + LEAA+A +EQ+GE A+ DA  
Sbjct: 307 TVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARC 366

Query: 352 KLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSI 411
           KL+ELE ALQ+AKQDMA  +REYQE+MN KL LDIEIATYR+LLEGEE RL  G+  +++
Sbjct: 367 KLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGIGAVNV 426

Query: 412 HTKTTSG 418
              ++ G
Sbjct: 427 CVSSSRG 433


>gi|226246665 keratin 72 isoform 2 [Homo sapiens]
          Length = 469

 Score =  397 bits (1020), Expect = e-110
 Identities = 229/456 (50%), Positives = 300/456 (65%), Gaps = 58/456 (12%)

Query: 9   SYKVSTSGPRAFSSRSYTSGPGSR-ISSSSFSRVGSSNFRGGLGGGYGGAS--------- 58
           S++    G  +F S+S +   GSR ++ S+ +R G     G +G  +G A          
Sbjct: 33  SFRARVKGSASFGSKSLSCLGGSRSLALSAAARRGGGRLGGFVGTAFGSAGLGPKCPSVC 92

Query: 59  GMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKM 118
             GGI  VTVN+SLL+PL +E+DP IQ VR QE+EQIK LNNKFASFIDKVRFLEQQN++
Sbjct: 93  PPGGIPQVTVNKSLLAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQNQV 152

Query: 119 LETKWSLLQQQ--KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFK 176
           LETKW+LLQQ      R N++ ++E YI+NL++QLE L  + ++L++EL NMQ LVED+K
Sbjct: 153 LETKWNLLQQLDLNNCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSELRNMQDLVEDYK 212

Query: 177 NKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQ 236
            +YE EIN+RT  ENEFV++KKDVD AYMNKVEL+++++ LTDEI F + LYE EI ++Q
Sbjct: 213 KRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEITQIQ 272

Query: 237 SQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKH 296
           S ISDTS+VLSMDN+R LD+DSIIAEV+AQYE+IA +S+AEAE++YQ K           
Sbjct: 273 SHISDTSIVLSMDNNRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKC---------- 322

Query: 297 GDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSEL 356
                                           A LE AIADAEQRG+ A+KDA AKL EL
Sbjct: 323 --------------------------------ADLETAIADAEQRGDCALKDARAKLDEL 350

Query: 357 EAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQN---MSIHT 413
           E AL +AK+++AR LREYQEL+++KLALD+EIATYRKLLE EE R+     N   +S+ +
Sbjct: 351 EGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVIS 410

Query: 414 KTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGS 449
            T +G AGG   + G   S   SY   ++     GS
Sbjct: 411 STNAG-AGGAGFSMGFGASSSYSYKTAAADVKTKGS 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,655,330
Number of Sequences: 37866
Number of extensions: 632667
Number of successful extensions: 8582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 640
Number of HSP's that attempted gapping in prelim test: 4900
Number of HSP's gapped (non-prelim): 2634
length of query: 483
length of database: 18,247,518
effective HSP length: 106
effective length of query: 377
effective length of database: 14,233,722
effective search space: 5366113194
effective search space used: 5366113194
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.