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Search of human proteins with 4504053
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504053 guanine nucleotide-binding protein, beta-3 subunit
[Homo sapiens]
(340 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 701 0.0
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 612 e-175
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 593 e-170
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 588 e-168
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 368 e-102
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 368 e-102
gi|32189425 WD repeat domain 69 [Homo sapiens] 128 6e-30
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 117 2e-26
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 112 6e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 110 2e-24
gi|16554627 WD repeat domain 5 [Homo sapiens] 110 2e-24
gi|23199987 WD repeat domain 5B [Homo sapiens] 108 9e-24
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 106 3e-23
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 106 3e-23
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 106 3e-23
gi|113865883 WD repeat domain 38 [Homo sapiens] 105 4e-23
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 104 1e-22
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 100 1e-21
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 100 1e-21
gi|21071067 TBP-associated factor 5 [Homo sapiens] 100 2e-21
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 99 5e-21
gi|157266266 WD repeat domain 86 [Homo sapiens] 95 1e-19
gi|13376840 WD repeat domain 61 [Homo sapiens] 94 2e-19
gi|26665869 WD repeat domain 51B [Homo sapiens] 94 2e-19
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 93 4e-19
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 91 1e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 91 2e-18
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 91 2e-18
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 90 3e-18
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 89 4e-18
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 701 bits (1809), Expect = 0.0
Identities = 340/340 (100%), Positives = 340/340 (100%)
Query: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA
Sbjct: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
Query: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM
Sbjct: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
Query: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF
Sbjct: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
Query: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA
Sbjct: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
Query: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM
Sbjct: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
Query: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN
Sbjct: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 612 bits (1578), Expect = e-175
Identities = 283/340 (83%), Positives = 315/340 (92%)
Query: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
M E++QLRQEAEQLK QI DARKACAD TL+++ + ++ VGR+QMRTRRTLRGHLAKIYA
Sbjct: 1 MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
MHW TDS+LLVSASQDGKLI+WDSYTTNKVHAIPLRSSWVMTCAYAPSGN+VACGGLDN+
Sbjct: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
Query: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
CSIYNLK+REGNV+VSREL+ HTGYLSCCRFLDDN IVTSSGDTTCALWDIETGQQ T F
Sbjct: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180
Query: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
GHTGD MSL+++PD LF+SGACDASAKLWDVREG CRQTFTGHESDINAICFFPNG A
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
TGSDDA+CRLFDLRADQEL+ +SH++IICGITSV+FS SGRLL AGYDDFNCNVWD++
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
K++R G+L+GHDNRVSCLGVT DGMAVATGSWDSFLKIWN
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 593 bits (1528), Expect = e-170
Identities = 275/340 (80%), Positives = 306/340 (90%)
Query: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
M E+EQLRQEAEQL+ QI DARKAC D TL ++ +GL+ VGR+QMRTRRTLRGHLAKIYA
Sbjct: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
MHW TDS+LLVSASQDGKLI+WDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDN+
Sbjct: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
Query: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
CSIY+LK+REGNV+VSREL HTGYLSCCRFLDDN I+TSSGDTTCALWDIETGQQ F
Sbjct: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
Query: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
GH+GD MSL+++PD F+SGACDAS KLWDVR+ CRQTF GHESDINA+ FFPNG A
Sbjct: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
Query: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
TGSDDA+CRLFDLRADQEL+ +SH++IICGITSVAFS SGRLL AGYDDFNCN+WD+M
Sbjct: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
Query: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
K +R G+L+GHDNRVSCLGVT DGMAVATGSWDSFLKIWN
Sbjct: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 588 bits (1516), Expect = e-168
Identities = 271/340 (79%), Positives = 306/340 (90%)
Query: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
M E+EQLRQEAEQL+ QI DARKAC D TL ++ S ++ VGR+QMRTRRTLRGHLAKIYA
Sbjct: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
MHW DS+LLVSASQDGKLI+WDSYTTNK+HAIPLRSSWVMTCAYAPSGN+VACGGLDN+
Sbjct: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
Query: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
CSIYNLK+REGNV+VSREL HTGYLSCCRFLDD+ IVTSSGDTTCALWDIET QQ T F
Sbjct: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
Query: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
GH+GD MSL++SPD F+SGACDAS+KLWD+R+G CRQ+FTGH SDINA+ FFPNG A
Sbjct: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
Query: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
TGSDDA+CRLFDLRADQEL+ +SH++IICGITSVAFS SGRLL AGYDDFNCNVWD++
Sbjct: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
Query: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
K +R G+L+GHDNRVSCLGVT DGMAVATGSWDSFL+IWN
Sbjct: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 368 bits (944), Expect = e-102
Identities = 178/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%)
Query: 4 MEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHW 63
+ L+ EAE LK ++ + R DV L ++ +E +G+ M+TRRTL+GH K+ M W
Sbjct: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
Query: 64 ATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSI 123
D + +VS+SQDGK+IVWDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
Query: 124 YNLK--SREGNVKVSRELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVF 180
Y L E + ++ HT YLS C F + D I+T+SGD TCALWD+E+GQ F
Sbjct: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Query: 181 VGHTGD--CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNG 238
GH D C+ LA S N F+SG CD A +WD+R G C Q F HESDIN++ ++P+G
Sbjct: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
Query: 239 EAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD 298
+A +GSDDA+CRL+DLRAD+E+ +S ESII G +SV FSLSGRLLFAGY+D+ NVWD
Sbjct: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
Query: 299 SMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
+K RV IL GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 56.2 bits (134), Expect = 4e-08
Identities = 50/215 (23%), Positives = 87/215 (40%), Gaps = 7/215 (3%)
Query: 133 VKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLA 191
+K R L H + C + D IV+SS D +WD T ++ M+ A
Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112
Query: 192 VSPDFNLFISGACDASAKLW----DVREGTC--RQTFTGHESDINAICFFPNGEAICTGS 245
+P G D ++ D E +++ H + ++A F + I T S
Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172
Query: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
D +C L+D+ + Q L F +A S +G +G D VWD + V
Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232
Query: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
H++ ++ + G A A+GS D+ ++++
Sbjct: 233 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 368 bits (944), Expect = e-102
Identities = 178/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%)
Query: 4 MEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHW 63
+ L+ EAE LK ++ + R DV L ++ +E +G+ M+TRRTL+GH K+ M W
Sbjct: 54 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
Query: 64 ATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSI 123
D + +VS+SQDGK+IVWDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
Query: 124 YNLK--SREGNVKVSRELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVF 180
Y L E + ++ HT YLS C F + D I+T+SGD TCALWD+E+GQ F
Sbjct: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
Query: 181 VGHTGD--CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNG 238
GH D C+ LA S N F+SG CD A +WD+R G C Q F HESDIN++ ++P+G
Sbjct: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
Query: 239 EAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD 298
+A +GSDDA+CRL+DLRAD+E+ +S ESII G +SV FSLSGRLLFAGY+D+ NVWD
Sbjct: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
Query: 299 SMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
+K RV IL GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 56.2 bits (134), Expect = 4e-08
Identities = 50/215 (23%), Positives = 87/215 (40%), Gaps = 7/215 (3%)
Query: 133 VKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLA 191
+K R L H + C + D IV+SS D +WD T ++ M+ A
Sbjct: 95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 154
Query: 192 VSPDFNLFISGACDASAKLW----DVREGTC--RQTFTGHESDINAICFFPNGEAICTGS 245
+P G D ++ D E +++ H + ++A F + I T S
Sbjct: 155 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 214
Query: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
D +C L+D+ + Q L F +A S +G +G D VWD + V
Sbjct: 215 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 274
Query: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
H++ ++ + G A A+GS D+ ++++
Sbjct: 275 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 128 bits (322), Expect = 6e-30
Identities = 81/293 (27%), Positives = 137/293 (46%), Gaps = 10/293 (3%)
Query: 50 TLRGHLAKIYAMHWATD-SKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
TL GH +YA+ + + + S D +W T H ++ ++ ++ P
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCAL 168
VA G +D ++++++ E V R SA +S + I+T S D T +
Sbjct: 189 STLVATGSMDTTAKLWDIQNGE-EVYTLRGHSAEI--ISLSFNTSGDRIITGSFDHTVVV 245
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
WD +TG++ + +GH + S + + D +L ++G+ D + KLWD G C T TGH+ +
Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
Query: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELIC--FSHESIICGITSVAFSLSGRLLF 286
I CF G+ I T S D + R+F A ++ I HE I+ ++F+ G L
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFS-AATRKCIAKLEGHEG---EISKISFNPQGNHLL 361
Query: 287 AGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
G D +WD+ + + +L GH + + G V TGS D+ +IW
Sbjct: 362 TGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 118 bits (296), Expect = 7e-27
Identities = 80/260 (30%), Positives = 127/260 (48%), Gaps = 25/260 (9%)
Query: 89 KVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSC 148
K H +PL + A SG+ G D C +++ S E EL+ G+ +
Sbjct: 89 KAHILPLTN-----VALNKSGSCFITGSYDRTCKLWDTASGE-------ELNTLEGHRNV 136
Query: 149 CRFLDDNN-----IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGA 203
+ NN I T S D TC LW +ETG+ F GHT + + L+ +P L +G+
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
Query: 204 CDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL-I 262
D +AKLWD++ G T GH ++I ++ F +G+ I TGS D + ++D +++ I
Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256
Query: 263 CFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV--SCLGV 320
H I+S +F+ L+ G D C +WD+ + V L+GHD+ + SC
Sbjct: 257 LIGH---CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
Query: 321 TADGMAVATGSWDSFLKIWN 340
T G +AT S D +I++
Sbjct: 314 T--GKLIATASADGTARIFS 331
Score = 78.2 bits (191), Expect = 1e-14
Identities = 47/164 (28%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 179 VFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICF-FPN 237
V H ++A++ + FI+G+ D + KLWD G T GH + + AI F P
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 238 GEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFAGYDDFNCNV 296
G+ I TGS D +C+L+ + + C+ + I ++F+ L+ G D +
Sbjct: 147 GDKIATGSFDKTCKLWSVETGK---CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 297 WDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
WD E V L GH + L G + TGS+D + +W+
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 117 bits (292), Expect = 2e-26
Identities = 82/260 (31%), Positives = 127/260 (48%), Gaps = 15/260 (5%)
Query: 48 RRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAP 107
+R LRGH + + ++D + +S S DG L +WD T + V++ A++
Sbjct: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
Query: 108 SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL--DDNNIVTSSG-DT 164
+ G D ++N G K + + +H+ ++SC RF N I+ S G D
Sbjct: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 165 TCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTG 224
+W++ + KT +GHTG ++ VSPD +L SG D A LWD+ EG T G
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
Query: 225 HESDINAICFFPNGEAICTGSDDASCRLFDLRA-------DQELICFSHESIICGITSVA 277
+ INA+CF PN +C + S +++DL QE+I S ++ TS+A
Sbjct: 233 GDI-INALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
Query: 278 FSLSGRLLFAGYDDFNCNVW 297
+S G+ LFAGY D VW
Sbjct: 291 WSADGQTLFAGYTDNLVRVW 310
Score = 72.0 bits (175), Expect = 7e-13
Identities = 67/252 (26%), Positives = 105/252 (41%), Gaps = 14/252 (5%)
Query: 97 SSWVMTCAYAPS-GNFVACGGLDNMCSIYNLKSREGNVKV-SRELSAHTGYLSCCRFLDD 154
+ WV A P + + D ++ L E N + R L H+ ++S D
Sbjct: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74
Query: 155 NNIVTS-SGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDV 213
S S D T LWD+ TG FVGHT D +S+A S D +SG+ D + KLW+
Sbjct: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134
Query: 214 REGTCRQTF--TGHESDINAICFFPNGE--AICTGSDDASCRLFDLRADQELICFSHESI 269
G C+ T H ++ + F PN I + D ++++L + + +H
Sbjct: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGH 191
Query: 270 ICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHD-NRVSCLGVTADGMAVA 328
+ +V S G L +G D +WD + + + L G D C + A
Sbjct: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251
Query: 329 TGSWDSFLKIWN 340
TG +KIW+
Sbjct: 252 TG---PSIKIWD 260
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/225 (22%), Positives = 82/225 (36%), Gaps = 59/225 (26%)
Query: 47 TRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIP-LRSSWVMTCAY 105
T R GH + ++ +++D++ +VS S+D + +W++ K S WV +
Sbjct: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRF 156
Query: 106 APSGN---FVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG 162
+P+ + V+CG D + ++NL N K+ HTGYL+ D ++ S G
Sbjct: 157 SPNSSNPIIVSCGW-DKLVKVWNL----ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211
Query: 163 -DTTCALWDIETGQQKTVFVGH------------------TG------------------ 185
D LWD+ G+ G TG
Sbjct: 212 KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271
Query: 186 -------------DCMSLAVSPDFNLFISGACDASAKLWDVREGT 217
C SLA S D +G D ++W V GT
Sbjct: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 112 bits (279), Expect = 6e-25
Identities = 80/295 (27%), Positives = 136/295 (46%), Gaps = 30/295 (10%)
Query: 62 HWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG---------NFV 112
H++ +SK+L +A G +W N +H + ++ V + P N
Sbjct: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
Query: 113 ACGGLDNMCSIYNLKSREG-------NVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165
+C D +++L S E V+V+R + +G RFL T+ D +
Sbjct: 298 SCAA-DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG-----RFLG-----TTCYDRS 346
Query: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225
LWD+E ++ GH+ +A D +L +G DA ++WD+R G C GH
Sbjct: 347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406
Query: 226 ESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRL 284
+I I F PNG I TGS D +C+++DLR + + +H++++ G+ + G
Sbjct: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE--PIHGNF 464
Query: 285 LFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
L G D +W + L+GH+ +V L +++DG +AT S+D K+W
Sbjct: 465 LLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 75.5 bits (184), Expect = 6e-14
Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 13/205 (6%)
Query: 146 LSCCRFLDDNNIV-TSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSP---------D 195
+S C F ++ ++ T+ C LW + GH + ++ P D
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
Query: 196 FNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDL 255
NL S A D S KLW + GH + + + P+G + T D S RL+DL
Sbjct: 294 VNL-ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 256 RADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 315
A +E++ E G+ +AF G L G D VWD + L GH +
Sbjct: 353 EAQEEIL--HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 316 SCLGVTADGMAVATGSWDSFLKIWN 340
+ + +G +ATGS D+ K+W+
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWD 435
Score = 65.9 bits (159), Expect = 5e-11
Identities = 49/211 (23%), Positives = 88/211 (41%), Gaps = 18/211 (8%)
Query: 51 LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
+ GH ++ + W + L + D +WD ++ S V A+ G+
Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
Query: 111 FVACGGLDNMCSIYNLKS------REGNVKVSRELS-AHTGYLSCCRFLDDNNIVTSSGD 163
GGLD +++L++ EG++K ++ + GY +I T SGD
Sbjct: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY----------HIATGSGD 428
Query: 164 TTCALWDIETGQQKTVFVGHTGDCMSLAVSP-DFNLFISGACDASAKLWDVREGTCRQTF 222
TC +WD+ + H + P N ++GA D +AK+W + +T
Sbjct: 429 NTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTL 488
Query: 223 TGHESDINAICFFPNGEAICTGSDDASCRLF 253
GHE + + +G+ I T S D + +L+
Sbjct: 489 AGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 52.8 bits (125), Expect = 4e-07
Identities = 42/143 (29%), Positives = 62/143 (43%), Gaps = 10/143 (6%)
Query: 36 GLEVVGRV-QMRTRRT---LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVH 91
GL+ GRV +RT R L GHL +IY ++++ + + + S D VWD V+
Sbjct: 384 GLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVY 443
Query: 92 AIPLRSSWVMTCAYAP-SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR 150
IP + V + P GNF+ G DN I+ + L+ H G +
Sbjct: 444 TIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT----HPGWSPLKTLAGHEGKVMGLD 499
Query: 151 FLDDNNIV-TSSGDTTCALWDIE 172
D ++ T S D T LW E
Sbjct: 500 ISSDGQLIATCSYDRTFKLWMAE 522
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 110 bits (275), Expect = 2e-24
Identities = 67/245 (27%), Positives = 120/245 (48%), Gaps = 9/245 (3%)
Query: 100 VMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNI-V 158
V + ++P+G ++A D + I+ + +G K + +S H +S + D+N+ V
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWG--AYDG--KFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 159 TSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTC 218
++S D T +WD+ +G+ GH+ +P NL +SG+ D S ++WDV+ G C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 219 RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAF 278
+T H ++A+ F +G I + S D CR++D + Q L + ++ V F
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD-NPPVSFVKF 222
Query: 279 SLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV---TADGMAVATGSWDSF 335
S +G+ + A D +WD K + + +GH N C+ G + +GS D+
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 336 LKIWN 340
+ IWN
Sbjct: 283 VYIWN 287
Score = 109 bits (273), Expect = 3e-24
Identities = 68/230 (29%), Positives = 116/230 (50%), Gaps = 13/230 (5%)
Query: 37 LEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLR 96
+++ G + +T+ GH I + W++DS LLVSAS D L +WD + + +
Sbjct: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
S++V C + P N + G D I+++K+ K + L AH+ +S F D +
Sbjct: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGS 184
Query: 157 -IVTSSGDTTCALWDIETGQ-QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
IV+SS D C +WD +GQ KT+ + SP+ ++ D + KLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Query: 215 EGTCRQTFTGHESDINAICFFPN-----GEAICTGSDDASCRLFDLRADQ 259
+G C +T+TGH+++ C F N G+ I +GS+D +++L+ +
Sbjct: 245 KGKCLKTYTGHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292
Score = 97.4 bits (241), Expect = 2e-20
Identities = 69/295 (23%), Positives = 135/295 (45%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ ++ + + L S+S D + +W +Y I + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCAL 168
N + D I+++ S K + L H+ Y+ CC F +N IV+ S D + +
Sbjct: 100 NLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES- 227
WD++TG+ H+ ++ + D +L +S + D ++WD G C +T ++
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 228 DINAICFFPNGEAICTGSDDASCRLFDLRADQELICFS-HESIICGITSVAFSLSGRLLF 286
++ + F PNG+ I + D + +L+D + L ++ H++ I + G+ +
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 287 AGYDDFNCNVWDSMKSERVGILSGHDNRV--SCLGVTADGMAVATGSWDSFLKIW 339
+G +D +W+ E V L GH + V + T + +A A D +K+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 68.9 bits (167), Expect = 6e-12
Identities = 39/166 (23%), Positives = 75/166 (45%), Gaps = 6/166 (3%)
Query: 177 KTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFP 236
K GHT S+ SP+ S + D K+W +G +T +GH+ I+ + +
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 237 NGEAICTGSDDASCRLFDLRADQELICFSHES--IICGITSVAFSLSGRLLFAGYDDFNC 294
+ + + SDD + +++D+ + + L S + C F+ L+ +G D +
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC----CNFNPQSNLIVSGSFDESV 153
Query: 295 NVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
+WD + + L H + VS + DG + + S+D +IW+
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 35.8 bits (81), Expect = 0.056
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 49 RTLRGHLAK---IYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105
+T GH + I+A T K +VS S+D + +W+ T V + + V++ A
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 106 APSGNFVACGGLDNMCSIYNLKS 128
P+ N +A L+N +I KS
Sbjct: 310 HPTENIIASAALENDKTIKLWKS 332
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 110 bits (275), Expect = 2e-24
Identities = 67/245 (27%), Positives = 120/245 (48%), Gaps = 9/245 (3%)
Query: 100 VMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNI-V 158
V + ++P+G ++A D + I+ + +G K + +S H +S + D+N+ V
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWG--AYDG--KFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 159 TSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTC 218
++S D T +WD+ +G+ GH+ +P NL +SG+ D S ++WDV+ G C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 219 RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAF 278
+T H ++A+ F +G I + S D CR++D + Q L + ++ V F
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD-NPPVSFVKF 222
Query: 279 SLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV---TADGMAVATGSWDSF 335
S +G+ + A D +WD K + + +GH N C+ G + +GS D+
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 336 LKIWN 340
+ IWN
Sbjct: 283 VYIWN 287
Score = 109 bits (273), Expect = 3e-24
Identities = 68/230 (29%), Positives = 116/230 (50%), Gaps = 13/230 (5%)
Query: 37 LEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLR 96
+++ G + +T+ GH I + W++DS LLVSAS D L +WD + + +
Sbjct: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
S++V C + P N + G D I+++K+ K + L AH+ +S F D +
Sbjct: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGS 184
Query: 157 -IVTSSGDTTCALWDIETGQ-QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
IV+SS D C +WD +GQ KT+ + SP+ ++ D + KLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Query: 215 EGTCRQTFTGHESDINAICFFPN-----GEAICTGSDDASCRLFDLRADQ 259
+G C +T+TGH+++ C F N G+ I +GS+D +++L+ +
Sbjct: 245 KGKCLKTYTGHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292
Score = 97.4 bits (241), Expect = 2e-20
Identities = 69/295 (23%), Positives = 135/295 (45%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ ++ + + L S+S D + +W +Y I + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCAL 168
N + D I+++ S K + L H+ Y+ CC F +N IV+ S D + +
Sbjct: 100 NLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES- 227
WD++TG+ H+ ++ + D +L +S + D ++WD G C +T ++
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 228 DINAICFFPNGEAICTGSDDASCRLFDLRADQELICFS-HESIICGITSVAFSLSGRLLF 286
++ + F PNG+ I + D + +L+D + L ++ H++ I + G+ +
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 287 AGYDDFNCNVWDSMKSERVGILSGHDNRV--SCLGVTADGMAVATGSWDSFLKIW 339
+G +D +W+ E V L GH + V + T + +A A D +K+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 68.9 bits (167), Expect = 6e-12
Identities = 39/166 (23%), Positives = 75/166 (45%), Gaps = 6/166 (3%)
Query: 177 KTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFP 236
K GHT S+ SP+ S + D K+W +G +T +GH+ I+ + +
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 237 NGEAICTGSDDASCRLFDLRADQELICFSHES--IICGITSVAFSLSGRLLFAGYDDFNC 294
+ + + SDD + +++D+ + + L S + C F+ L+ +G D +
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC----CNFNPQSNLIVSGSFDESV 153
Query: 295 NVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
+WD + + L H + VS + DG + + S+D +IW+
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 35.8 bits (81), Expect = 0.056
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 49 RTLRGHLAK---IYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105
+T GH + I+A T K +VS S+D + +W+ T V + + V++ A
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 106 APSGNFVACGGLDNMCSIYNLKS 128
P+ N +A L+N +I KS
Sbjct: 310 HPTENIIASAALENDKTIKLWKS 332
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 108 bits (269), Expect = 9e-24
Identities = 72/283 (25%), Positives = 132/283 (46%), Gaps = 21/283 (7%)
Query: 74 SQDGKLIVWDSYTTNKVHAIPLRSSWVMTCA------------YAPSGNFVACGGLDNMC 121
S+D K + S + N+ +P ++ + C ++P+G ++A D +
Sbjct: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 122 SIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVF 180
I+ + +G K + L H +S + D++ +V++S D T LWD+ +G+
Sbjct: 66 IIWG--AYDG--KYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121
Query: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
GH+ +P NL ISG+ D + K+W+V+ G C +T + H ++A+ F +G
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
I +GS D CR++D + Q L + ++ V FS +G+ + D +WD
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDD-NPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Query: 301 KSERVGILSGHDNRVSCLGV---TADGMAVATGSWDSFLKIWN 340
+ + +GH N C+ G + +GS D+ + IWN
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 103 bits (256), Expect = 3e-22
Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 13/226 (5%)
Query: 41 GRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWV 100
G + +TL GH +I + W++DS LVSAS D L +WD + + + S++V
Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Query: 101 MTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVT 159
C + P N + G D I+ +K+ K + LSAH+ +S F + IV+
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTG----KCLKTLSAHSDPVSAVHFNCSGSLIVS 184
Query: 160 SSGDTTCALWDIETGQ-QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTC 218
S D C +WD +GQ KT+ + SP+ ++ D + KLWD G C
Sbjct: 185 GSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC 244
Query: 219 RQTFTGHESDINAICFFPN-----GEAICTGSDDASCRLFDLRADQ 259
+T+TGH+++ C F N G+ I +GS+D +++L+ +
Sbjct: 245 LKTYTGHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288
Score = 97.1 bits (240), Expect = 2e-20
Identities = 73/326 (22%), Positives = 151/326 (46%), Gaps = 10/326 (3%)
Query: 20 DARKACADVTLAELVS-GLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGK 78
++R A A + L+ + EV + TL GH + ++ ++ + + L S+S D
Sbjct: 5 ESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRL 64
Query: 79 LIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRE 138
+I+W +Y + + + A++ + + D +++++S K +
Sbjct: 65 IIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG----KCLKT 120
Query: 139 LSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFN 197
L H+ Y+ CC F +N I++ S D T +W+++TG+ H+ ++ + +
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
Query: 198 LFISGACDASAKLWDVREGTCRQTFTGHES-DINAICFFPNGEAICTGSDDASCRLFDLR 256
L +SG+ D ++WD G C +T ++ ++ + F PNG+ I T + D + +L+D
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Query: 257 ADQELICFS-HESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 315
+ L ++ H++ I + G+ + +G +D +W+ E V L GH + V
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Query: 316 --SCLGVTADGMAVATGSWDSFLKIW 339
+ T + +A A D +K+W
Sbjct: 301 ISAACHPTENLIASAALENDKTIKLW 326
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 106 bits (264), Expect = 3e-23
Identities = 67/213 (31%), Positives = 103/213 (48%), Gaps = 12/213 (5%)
Query: 129 REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCM 188
R G +K + L H ++ C N IV+ S D T +W TG+ VGHTG
Sbjct: 248 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 307
Query: 189 SLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDA 248
S + N+ ISG+ D + K+W+ G C T GH S + C + + + +GS DA
Sbjct: 308 SSQMRD--NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDA 363
Query: 249 SCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGI 307
+ R++D+ Q L + H + + V + GR + +G DF VWD +
Sbjct: 364 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 308 LSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
L GH NRV L DG+ V +GS D+ +++W+
Sbjct: 419 LQGHTNRVYSL--QFDGIHVVSGSLDTSIRVWD 449
Score = 76.6 bits (187), Expect = 3e-14
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 22/271 (8%)
Query: 37 LEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLR 96
L+V V + RTL GH +++ + +++S S D L VW++ T +H +
Sbjct: 285 LKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGH 342
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
+S V C + V+ G D ++++++ + L H + C ++ D
Sbjct: 343 TSTVR-CMHLHEKRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRR 395
Query: 157 IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
+V+ + D +WD ET GHT SL D +SG+ D S ++WDV G
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 453
Query: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF----SHESIICG 272
C T TGH+S + + N + +G+ D++ +++D++ Q L H+S
Sbjct: 454 NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS---A 508
Query: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSE 303
+T + F+ + + DD +WD E
Sbjct: 509 VTCLQFNKN--FVITSSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 106 bits (264), Expect = 3e-23
Identities = 67/213 (31%), Positives = 103/213 (48%), Gaps = 12/213 (5%)
Query: 129 REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCM 188
R G +K + L H ++ C N IV+ S D T +W TG+ VGHTG
Sbjct: 366 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 425
Query: 189 SLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDA 248
S + N+ ISG+ D + K+W+ G C T GH S + C + + + +GS DA
Sbjct: 426 SSQMRD--NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDA 481
Query: 249 SCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGI 307
+ R++D+ Q L + H + + V + GR + +G DF VWD +
Sbjct: 482 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 308 LSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
L GH NRV L DG+ V +GS D+ +++W+
Sbjct: 537 LQGHTNRVYSL--QFDGIHVVSGSLDTSIRVWD 567
Score = 76.6 bits (187), Expect = 3e-14
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 22/271 (8%)
Query: 37 LEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLR 96
L+V V + RTL GH +++ + +++S S D L VW++ T +H +
Sbjct: 403 LKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGH 460
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
+S V C + V+ G D ++++++ + L H + C ++ D
Sbjct: 461 TSTVR-CMHLHEKRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRR 513
Query: 157 IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
+V+ + D +WD ET GHT SL D +SG+ D S ++WDV G
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 571
Query: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF----SHESIICG 272
C T TGH+S + + N + +G+ D++ +++D++ Q L H+S
Sbjct: 572 NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS---A 626
Query: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSE 303
+T + F+ + + DD +WD E
Sbjct: 627 VTCLQFNKN--FVITSSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 106 bits (264), Expect = 3e-23
Identities = 67/213 (31%), Positives = 103/213 (48%), Gaps = 12/213 (5%)
Query: 129 REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCM 188
R G +K + L H ++ C N IV+ S D T +W TG+ VGHTG
Sbjct: 286 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 345
Query: 189 SLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDA 248
S + N+ ISG+ D + K+W+ G C T GH S + C + + + +GS DA
Sbjct: 346 SSQMRD--NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDA 401
Query: 249 SCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGI 307
+ R++D+ Q L + H + + V + GR + +G DF VWD +
Sbjct: 402 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 308 LSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
L GH NRV L DG+ V +GS D+ +++W+
Sbjct: 457 LQGHTNRVYSL--QFDGIHVVSGSLDTSIRVWD 487
Score = 76.6 bits (187), Expect = 3e-14
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 22/271 (8%)
Query: 37 LEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLR 96
L+V V + RTL GH +++ + +++S S D L VW++ T +H +
Sbjct: 323 LKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGH 380
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
+S V C + V+ G D ++++++ + L H + C ++ D
Sbjct: 381 TSTVR-CMHLHEKRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRR 433
Query: 157 IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
+V+ + D +WD ET GHT SL D +SG+ D S ++WDV G
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 491
Query: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF----SHESIICG 272
C T TGH+S + + N + +G+ D++ +++D++ Q L H+S
Sbjct: 492 NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS---A 546
Query: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSE 303
+T + F+ + + DD +WD E
Sbjct: 547 VTCLQFNKN--FVITSSDDGTVKLWDLKTGE 575
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 105 bits (263), Expect = 4e-23
Identities = 69/245 (28%), Positives = 115/245 (46%), Gaps = 11/245 (4%)
Query: 100 VMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVT 159
V + A++P G + G D +Y ++R G ++ L HTG + CRF D ++
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGC--VYGWETRSG--QLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 160 SSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTC 218
S+ D T LWD+ + V GH +++ SPD SG D LWDV+ G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 219 RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESI---ICGITS 275
+ GH I + F P + TGS D++ ++DLR + SH+++ I+
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAV--SHQALEGHSANISC 197
Query: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
+ +S SG LL +G D ++W S + L GH V + + D + +A+ +
Sbjct: 198 LCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
Query: 336 LKIWN 340
+K+W+
Sbjct: 257 VKVWD 261
Score = 102 bits (253), Expect = 6e-22
Identities = 62/203 (30%), Positives = 96/203 (47%), Gaps = 9/203 (4%)
Query: 142 HTGYLSCCRFLDDNNIVTSSGDTTCAL-WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFI 200
H G ++ F D ++ + + C W+ +GQ GHTG SPD +LF
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 201 SGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQE 260
S +CD + +LWDV C + GH+ + + F P+ + +G D L+D+++ Q
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 261 L-ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD-SMKSERVG--ILSGHDNRVS 316
L + H I S FS + L G D ++WD M + V L GH +S
Sbjct: 140 LRLLVGHRD---SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANIS 196
Query: 317 CLGVTADGMAVATGSWDSFLKIW 339
CL +A G+ +A+GSWD + IW
Sbjct: 197 CLCYSASGL-LASGSWDKTIHIW 218
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/285 (24%), Positives = 127/285 (44%), Gaps = 13/285 (4%)
Query: 54 HLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVA 113
H ++ + ++ D ++L++ S+DG + W++ + + + + V C ++P G+ A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 114 CGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIE 172
D ++++ K R L H + F D+ + S G D LWD++
Sbjct: 80 SASCDCTVRLWDV----ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ 135
Query: 173 TGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGT---CRQTFTGHESDI 229
+GQ + VGH S SP N +G+ D++ +WD+R T Q GH ++I
Sbjct: 136 SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Query: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGR-LLFAG 288
+ +C+ +G + +GS D + ++ LI + + + S+AFS L AG
Sbjct: 196 SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLI--QLKGHVTWVKSIAFSPDELWLASAG 252
Query: 289 YDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWD 333
Y VWD + + L G + T DG + +G+ D
Sbjct: 253 YSRM-VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/203 (24%), Positives = 89/203 (43%), Gaps = 1/203 (0%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R L+GH + + ++ DS+ L S D ++++WD + + + + + ++P+
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCAL 168
N +A G D+ I++L+ V + L H+ +SC + + + S D T +
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVS-HQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
W T GH S+A SPD S K+WD G C +T G
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 229 INAICFFPNGEAICTGSDDASCR 251
+ F P+G+ + +G+ D + R
Sbjct: 278 AHTCAFTPDGKILVSGAADQTRR 300
Score = 75.9 bits (185), Expect = 5e-14
Identities = 47/162 (29%), Positives = 75/162 (46%), Gaps = 4/162 (2%)
Query: 180 FVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGE 239
F H G+ S A SPD + ++G+ D W+ R G GH + F P+G
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 240 AICTGSDDASCRLFDL-RADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD 298
+ S D + RL+D+ RA + H+ + +V+FS R L +G D +WD
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQR---SVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 299 SMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
+ + +L GH + + + +ATGSWDS + IW+
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 104 bits (259), Expect = 1e-22
Identities = 82/339 (24%), Positives = 139/339 (41%), Gaps = 55/339 (16%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKV-HAIPLRSSWVMTCAYAP- 107
T +GH + ++ W+ D + L S ++G++++WD T +V + S W+ ++ P
Sbjct: 151 TCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL 210
Query: 108 ----SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD 163
+VA D I++ + + R L+ HT ++C R+ D + ++S D
Sbjct: 211 HANPECRYVASSSKDGSVRIWDTTAG----RCERILTGHTQSVTCLRWGGDGLLYSASQD 266
Query: 164 TTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL------------------------- 198
T +W G GH ++A+S D+ L
Sbjct: 267 RTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELK 326
Query: 199 -----------------FISGACDASAKLWDVREGTCRQT-FTGHESDINAICFFPNGEA 240
+SG+ D + LW E T TGH++ IN + F P+
Sbjct: 327 ERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRI 386
Query: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
+ + S D S +L+D R + L S + + +A+S RLL +G D VWD
Sbjct: 387 VASASFDKSIKLWDGRTGKYLA--SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
Query: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
+ L GH + V + + DG VA+G D L+IW
Sbjct: 445 AQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/360 (22%), Positives = 145/360 (40%), Gaps = 69/360 (19%)
Query: 38 EVVGRVQMRTRRT--LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPL 95
+ + RV+ TR T L GH + ++ ++ K L S S D + WD T
Sbjct: 95 QAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKG 154
Query: 96 RSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSC------- 148
WV++ +++P G +A G + +++ + + +V R L+ H+ +++
Sbjct: 155 HRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGK---QVGRTLAGHSKWITGLSWEPLH 211
Query: 149 ----CRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGAC 204
CR+ + +SS D + +WD G+ + + GHT L D L S +
Sbjct: 212 ANPECRY-----VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQ 265
Query: 205 DASAKLWDVREGTCRQTFTGHESDINAI-----------CFFP----------------- 236
D + K+W +G +T GH +N + F P
Sbjct: 266 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQEL 325
Query: 237 --------------NGEAICTGSDDASCRLFDLRADQELI--CFSHESIICGITSVAFSL 280
E + +GSDD + L+ D++ + H+++ I V FS
Sbjct: 326 KERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQAL---INQVLFSP 382
Query: 281 SGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
R++ + D + +WD + + L GH V + +AD + +GS DS LK+W+
Sbjct: 383 DSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 7/253 (2%)
Query: 46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105
R R L GH + + W D LL SASQD + VW ++ + WV T A
Sbjct: 237 RCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295
Query: 106 APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165
+ + + G + + N + +G+++ +E + L R +V+ S D T
Sbjct: 296 S-TDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL--VRGQGPERLVSGSDDFT 352
Query: 166 CALWD-IETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTG 224
LW E + T GH + SPD + S + D S KLWD R G + G
Sbjct: 353 LFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG 412
Query: 225 HESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRL 284
H + + I + + + +GS D++ +++D++A + + + +V +S G+
Sbjct: 413 HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK--LAMDLPGHADEVYAVDWSPDGQR 470
Query: 285 LFAGYDDFNCNVW 297
+ +G D +W
Sbjct: 471 VASGGKDKCLRIW 483
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 100 bits (250), Expect = 1e-21
Identities = 74/294 (25%), Positives = 126/294 (42%), Gaps = 11/294 (3%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R +GH + + ++ ++K L S S D L+VW ++ + V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDD-NNIVTSSGDTTCA 167
G+ +A G D I+ + + +G V R AHT + F D + VT+S D T
Sbjct: 73 GHLLASGSRDKTVRIW-VPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 168 LWDIETGQQKTVF--VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225
+W T +QK +F H SPD L +S + D + KLWD C ++ H
Sbjct: 129 VW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH 186
Query: 226 ESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLL 285
+ + F P+G I D + +++D+R + L + S + ++F SG L
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS--AAVNGLSFHPSGNYL 244
Query: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
D + D M+ + L GH + + + G A+G D + +W
Sbjct: 245 ITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 76.3 bits (186), Expect = 4e-14
Identities = 47/207 (22%), Positives = 88/207 (42%), Gaps = 3/207 (1%)
Query: 135 VSRELSAHTGYLSCCRF-LDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVS 193
+ R H ++C F ++ + + S D+ +W ++ + F GH + S
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 194 PDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLF 253
P +L SG+ D + ++W F H + + ++ F +G++ T SDD + +++
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 254 DLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDN 313
+ L FS I + FS GRL+ + DD +WD E V H
Sbjct: 131 ATHRQKFL--FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 314 RVSCLGVTADGMAVATGSWDSFLKIWN 340
V+ + G +A D+ +K+W+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 100 bits (250), Expect = 1e-21
Identities = 74/294 (25%), Positives = 126/294 (42%), Gaps = 11/294 (3%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R +GH + + ++ ++K L S S D L+VW ++ + V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDD-NNIVTSSGDTTCA 167
G+ +A G D I+ + + +G V R AHT + F D + VT+S D T
Sbjct: 73 GHLLASGSRDKTVRIW-VPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 168 LWDIETGQQKTVF--VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225
+W T +QK +F H SPD L +S + D + KLWD C ++ H
Sbjct: 129 VW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH 186
Query: 226 ESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLL 285
+ + F P+G I D + +++D+R + L + S + ++F SG L
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS--AAVNGLSFHPSGNYL 244
Query: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
D + D M+ + L GH + + + G A+G D + +W
Sbjct: 245 ITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 76.3 bits (186), Expect = 4e-14
Identities = 47/207 (22%), Positives = 88/207 (42%), Gaps = 3/207 (1%)
Query: 135 VSRELSAHTGYLSCCRF-LDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVS 193
+ R H ++C F ++ + + S D+ +W ++ + F GH + S
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 194 PDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLF 253
P +L SG+ D + ++W F H + + ++ F +G++ T SDD + +++
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 254 DLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDN 313
+ L FS I + FS GRL+ + DD +WD E V H
Sbjct: 131 ATHRQKFL--FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 314 RVSCLGVTADGMAVATGSWDSFLKIWN 340
V+ + G +A D+ +K+W+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 100 bits (248), Expect = 2e-21
Identities = 60/215 (27%), Positives = 102/215 (47%), Gaps = 6/215 (2%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
+ L GH +Y ++ D L+S+S+DG + +W T + + V ++P
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCA 167
G + GG D + ++ + + R + H ++C RF ++N + T S D T
Sbjct: 597 GYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
LWD+ G +F GH G SL SP+ +GA D LWD+ G GH
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712
Query: 228 DINAICFFPNGEAICTGSDDASCRLFD-LRADQEL 261
+ ++ F +GE + +GS D + RL+D ++A ++L
Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDL 747
Score = 100 bits (248), Expect = 2e-21
Identities = 67/204 (32%), Positives = 97/204 (47%), Gaps = 5/204 (2%)
Query: 139 LSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFN 197
L H+G + F D N +++SS D T LW ++T + GH SP
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 198 LFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LR 256
F+SG D A+LW + F GH +D+N F PN + TGS D + RL+D L
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 257 ADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVS 316
+ I H+ I +T FS +GR L G D +WD VG L GH + V
Sbjct: 659 GNCVRIFTGHKGPIHSLT---FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 317 CLGVTADGMAVATGSWDSFLKIWN 340
L + DG +A+GS D+ +++W+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/254 (24%), Positives = 111/254 (43%), Gaps = 21/254 (8%)
Query: 57 KIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGG 116
K+ ++ A+D L+ S D + D T +++ + S V +++P N++
Sbjct: 503 KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS 562
Query: 117 LDNMCSIYNLKS-------REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALW 169
D +++L++ + N V + GY V+ D LW
Sbjct: 563 EDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY----------FVSGGHDRVARLW 612
Query: 170 DIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229
+ Q +F GH D P+ N +G+ D + +LWDV G C + FTGH+ I
Sbjct: 613 ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPI 672
Query: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFAG 288
+++ F PNG + TG+ D L+D+ + H +C S+ FS G +L +G
Sbjct: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC---SLRFSRDGEILASG 729
Query: 289 YDDFNCNVWDSMKS 302
D +WD++K+
Sbjct: 730 SMDNTVRLWDAIKA 743
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 99.0 bits (245), Expect = 5e-21
Identities = 64/214 (29%), Positives = 100/214 (46%), Gaps = 15/214 (7%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD--SYTTNKV---HAIPLRSSWVMTC 103
+ LRGH +Y+ + DS L+S S+D + WD S+T + HA P+ W +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV---WDLDI 392
Query: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSG 162
+ P + A G D +++ R + H + C +F ++N + T S
Sbjct: 393 S--PYSLYFASGSHDRTARLWSFD----RTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 163 DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTF 222
D T LW + G +F GH G +SLA SP+ S D KLWD+ GT +
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 223 TGHESDINAICFFPNGEAICTGSDDASCRLFDLR 256
GH +I ++ F P+ I + S D S R++D+R
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
Score = 94.4 bits (233), Expect = 1e-19
Identities = 55/204 (26%), Positives = 99/204 (48%), Gaps = 5/204 (2%)
Query: 139 LSAHTGYLSCCRFL-DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFN 197
L H G + RFL D + +++ S D + WD+ + ++ GH L +SP
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
Query: 198 LFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA 257
F SG+ D +A+LW + + GH +D++ + F PN + TGS D + RL+ +
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 258 DQELICFS-HESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVS 316
+ F+ H + S+AFS +G+ L + +D +WD L GH + ++
Sbjct: 458 GNSVRLFTGHRG---PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 317 CLGVTADGMAVATGSWDSFLKIWN 340
L + D +A+ S D+ +++W+
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWD 538
Score = 60.5 bits (145), Expect = 2e-09
Identities = 56/258 (21%), Positives = 102/258 (39%), Gaps = 17/258 (6%)
Query: 84 SYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMC-SIYNLKSREGNVKVSRELSAH 142
S TT +A + T +P +A G DN C +++L+S++ + ++
Sbjct: 255 SLTTICFYAFYNTEQLLNTAEISPDSKLLAAG-FDNSCIKLWSLRSKKLKSE-PHQVDVS 312
Query: 143 TGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISG 202
+L+C +I+ D D G + + GH G S D + +S
Sbjct: 313 RIHLAC-------DILEEEDDE-----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC 360
Query: 203 ACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELI 262
+ D S + WD+ T + GH + + P +GS D + RL+ L
Sbjct: 361 SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR 420
Query: 263 CFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTA 322
++ + + V F + L G D +W + + V + +GH V L +
Sbjct: 421 IYAGH--LADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSP 478
Query: 323 DGMAVATGSWDSFLKIWN 340
+G +A+ D LK+W+
Sbjct: 479 NGKYLASAGEDQRLKLWD 496
Score = 34.3 bits (77), Expect = 0.16
Identities = 16/39 (41%), Positives = 23/39 (58%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT 87
+ LRGH I ++ ++ DS L+ SAS D + VWD T
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 94.7 bits (234), Expect = 1e-19
Identities = 77/304 (25%), Positives = 124/304 (40%), Gaps = 35/304 (11%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R H I + + D + L++ S+DG +W + + S+V C
Sbjct: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR--FLDDNNIVTSSGDTTC 166
F C+I R +V + L + G+ S + +N + +SS D T
Sbjct: 69 AAFTCSAD----CTI-----RRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTA 119
Query: 167 ALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL--------------FISGACDASAKLWD 212
+W ++ GQ F GH ++LA S ++L ++G+ D +AK+W
Sbjct: 120 RVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
Query: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE--SII 270
V G C QT GH + + G TGS DA+ R +D+ + ++L F S+I
Sbjct: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Query: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330
C L RL+++G D W + E V + H VS L A + TG
Sbjct: 240 C------LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTG 291
Query: 331 SWDS 334
S D+
Sbjct: 292 SGDA 295
Score = 66.2 bits (160), Expect = 4e-11
Identities = 50/202 (24%), Positives = 77/202 (38%), Gaps = 33/202 (16%)
Query: 139 LSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL 198
L H Y++ C+ L+D T S D T WD+ TGQ V+ GHT + V+ N
Sbjct: 53 LQGHESYVTFCQ-LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--NQ 109
Query: 199 FISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRAD 258
S + D +A++W V +G + F GH + + + + + T + +
Sbjct: 110 LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA-------- 161
Query: 259 QELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCL 318
+G LL G D VW L GH V CL
Sbjct: 162 ----------------------AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
Query: 319 GVTADGMAVATGSWDSFLKIWN 340
+ G TGS D+ ++ W+
Sbjct: 200 VLDTPGHTAFTGSTDATIRAWD 221
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/181 (28%), Positives = 73/181 (40%), Gaps = 22/181 (12%)
Query: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
G V H G L++SPD ++G+ D +A+LW +G C GHES + C
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV-TFC 63
Query: 234 FFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFAGYDDF 292
+ EA T S D + R +D+ Q L + H SI+ I ++ LF+ D
Sbjct: 64 QLED-EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL-----VANNQLFSSSYDR 117
Query: 293 NCNVWDSMKSERVGILSGHDNRV--------------SCLGVTADGMAVATGSWDSFLKI 338
VW K + GH N V C A G + TGS D K+
Sbjct: 118 TARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKV 177
Query: 339 W 339
W
Sbjct: 178 W 178
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/166 (22%), Positives = 64/166 (38%), Gaps = 9/166 (5%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
+TLRGH + + T + S D + WD + ++ V+
Sbjct: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV-- 244
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCAL 168
V G D + + E R +AH +S ++ + T SGD
Sbjct: 245 NRLVYSGSADRTVKCWLADTGE----CVRTFTAHRRNVSALKY-HAGTLFTGSGDACARA 299
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
+D ++G+ + VF GHT + V + + + D + +LWDVR
Sbjct: 300 FDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHDGALRLWDVR 343
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 93.6 bits (231), Expect = 2e-19
Identities = 49/197 (24%), Positives = 99/197 (50%), Gaps = 5/197 (2%)
Query: 59 YAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLD 118
+ + ++ DS+ L + + GK+ ++ + K +++ R ++++ AY+P G ++A G +D
Sbjct: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
Query: 119 NMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNI-VTSSGDTTCALWDIETGQQK 177
+ +I+++ + K+ L H + F D+ + VT+S D ++D++
Sbjct: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
Query: 178 TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPN 237
GH +++A PD F+S + D S K+WDV TC TF H+ + + + N
Sbjct: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
Query: 238 GEAICTGSDDASCRLFD 254
G I + DD ++D
Sbjct: 286 GSKIVSVGDDQEIHIYD 302
Score = 72.0 bits (175), Expect = 7e-13
Identities = 55/251 (21%), Positives = 108/251 (43%), Gaps = 9/251 (3%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
+L GH + ++ + + S+S D + +WD ++ +I T A++P
Sbjct: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCAL 168
++A G +I+ ++S K L ++ + D + S D +
Sbjct: 119 QYLATGTHVGKVNIFGVESG----KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
+DI TG+ GH SL SPD L ++ + D K++DV+ T +GH S
Sbjct: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
Query: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFA 287
+ + F P+ + S D S +++D+ + F H+ + G V ++ +G + +
Sbjct: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG---VKYNGNGSKIVS 291
Query: 288 GYDDFNCNVWD 298
DD +++D
Sbjct: 292 VGDDQEIHIYD 302
Score = 71.6 bits (174), Expect = 9e-13
Identities = 60/231 (25%), Positives = 100/231 (43%), Gaps = 7/231 (3%)
Query: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHT-GYLSCCRFLDDNNIVTSSGDTTCALWD 170
V G LD++ ++ K R+ + + L H G +S +SS D LWD
Sbjct: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Query: 171 IETGQQ-KTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229
+E G+Q K++ G D +LA SPD +G ++ V G + I
Sbjct: 93 LENGKQIKSIDAGPV-DAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
Query: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGY 289
+I + P+G+ + +G+ D +FD+ + L + E I S+ FS +LL
Sbjct: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLL--HTLEGHAMPIRSLTFSPDSQLLVTAS 209
Query: 290 DDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
DD ++D + G LSGH + V + D + S D +K+W+
Sbjct: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
Score = 59.7 bits (143), Expect = 4e-09
Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 4/190 (2%)
Query: 153 DDNNIVTSSGDTTCALWDI--ETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKL 210
+ +VT S D +W E + GH +S+ +S + S + DA +L
Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
Query: 211 WDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESII 270
WD+ G ++ D + F P+ + + TG+ +F + + ++ +S ++
Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE--YSLDTRG 148
Query: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330
I S+A+S G+ L +G D N++D + + L GH + L + D + T
Sbjct: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
Query: 331 SWDSFLKIWN 340
S D ++KI++
Sbjct: 209 SDDGYIKIYD 218
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 93.6 bits (231), Expect = 2e-19
Identities = 68/292 (23%), Positives = 123/292 (42%), Gaps = 7/292 (2%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R +GH A I ++ + + K L +AS D L++W+ + + V + ++P
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCA 167
GN +A D ++ + + G E AHT + F D + T+S D +
Sbjct: 72 GNLLASASRDRTVRLW-IPDKRGKFS---EFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
+W + + HT SPD L +S + D + K+WD C F+
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
Query: 228 DINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFA 287
N + F P+G I + D + +++D+R ++ L + S G+ ++F SG L
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHS--GGVNCISFHPSGNYLIT 245
Query: 288 GYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
D + D ++ + L GH V + + G A+G D+ + +W
Sbjct: 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 82.0 bits (201), Expect = 7e-16
Identities = 48/213 (22%), Positives = 91/213 (42%), Gaps = 6/213 (2%)
Query: 52 RGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
+ H A + ++ ++ D + L +AS+D + VW Y ++++ + WV ++P G
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWD 170
+ D I++ +++ S G+ + F + S+G D T +WD
Sbjct: 159 IVSCSEDKTIKIWDTTNKQ----CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
Query: 171 IETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDIN 230
+ + + H+G ++ P N I+ + D + K+ D+ EG T GH +
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
Query: 231 AICFFPNGEAICTGSDDASCRLFDLRADQELIC 263
+ F GE +G D L+ D EL C
Sbjct: 275 TVSFSKGGELFASGGADTQVLLWRTNFD-ELHC 306
Score = 69.3 bits (168), Expect = 5e-12
Identities = 43/184 (23%), Positives = 82/184 (44%), Gaps = 2/184 (1%)
Query: 157 IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
+ T+S DT LW+ + + +VGH S+ SP NL S + D + +LW +
Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR 92
Query: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSV 276
F H + + ++ F +G+ + T S+D S +++ + + L +S +
Sbjct: 93 GKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFL--YSLYRHTHWVRCA 150
Query: 277 AFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFL 336
FS GRL+ + +D +WD+ + V S + + G +A+ D +
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
Query: 337 KIWN 340
K+W+
Sbjct: 211 KVWD 214
Score = 69.3 bits (168), Expect = 5e-12
Identities = 43/176 (24%), Positives = 79/176 (44%), Gaps = 5/176 (2%)
Query: 37 LEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLR 96
++V + R +L H + ++ D +L+VS S+D + +WD+ V+
Sbjct: 126 IKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDS 185
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
+ + PSG +A G D +++++ K+ + H+G ++C F N
Sbjct: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN----KLLQHYQVHSGGVNCISFHPSGN 241
Query: 157 -IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLW 211
++T+S D T + D+ G+ GHTG +++ S LF SG D LW
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 64.3 bits (155), Expect = 1e-10
Identities = 40/161 (24%), Positives = 71/161 (44%), Gaps = 2/161 (1%)
Query: 180 FVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGE 239
F GH SL +SP+ + + D LW+ + + GH+ + ++ F P+G
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 240 AICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDS 299
+ + S D + RL+ D+ ++ + SV FS G+ L +D + VW
Sbjct: 74 LLASASRDRTVRLW--IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 300 MKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
+ + L H + V C + DG + + S D +KIW+
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Score = 30.4 bits (67), Expect = 2.4
Identities = 17/81 (20%), Positives = 33/81 (40%)
Query: 54 HLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVA 113
H + + + L++AS DG L + D ++ + + V T +++ G A
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286
Query: 114 CGGLDNMCSIYNLKSREGNVK 134
GG D ++ E + K
Sbjct: 287 SGGADTQVLLWRTNFDELHCK 307
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 92.8 bits (229), Expect = 4e-19
Identities = 81/333 (24%), Positives = 148/333 (44%), Gaps = 40/333 (12%)
Query: 37 LEVVGRVQMRTRRT--LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD------SYTTN 88
+EV G V++ + LRGH ++++ W S LL S S D +W+ S +T
Sbjct: 149 MEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQ 208
Query: 89 KVHAIPLRSSW--------VMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELS 140
V +R V + + G +A G D I+ +++GN+ + L
Sbjct: 209 LVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW---TKDGNL--ASTLG 263
Query: 141 AHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLF 199
H G + ++ N + S+G D T +WD TG+ K F H+ + + + N F
Sbjct: 264 QHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NTF 322
Query: 200 ISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQ 259
S + D + + + +TF GH +++NAI + P G + + SDD + +++ ++ D
Sbjct: 323 ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDN 382
Query: 260 ---ELICFSHESIICGITSVAFSLSGR---------LLFAGYDDFNCNVWDSMKSERVGI 307
+L + E I ++ +S +G +L + D +WD + +
Sbjct: 383 CVHDLQAHNKE-----IYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHT 437
Query: 308 LSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
L+ H V + + DG +A+GS+D + IWN
Sbjct: 438 LTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Score = 80.1 bits (196), Expect = 3e-15
Identities = 61/262 (23%), Positives = 113/262 (43%), Gaps = 18/262 (6%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D I+WD++T P S+ + + +
Sbjct: 261 TLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 320
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCAL 168
F +C +MC I+ K G + + HT ++ ++ N++ S S D T +
Sbjct: 321 TFASCS--TDMC-IHVCKL--GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKI 375
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSP--------DFNLFISGAC-DASAKLWDVREGTCR 219
W ++ H + ++ SP + NL ++ A D++ +LWDV G C
Sbjct: 376 WSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICI 435
Query: 220 QTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFS 279
T T H+ + ++ F P+G + +GS D +++ + + + GI V ++
Sbjct: 436 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG---GIFEVCWN 492
Query: 280 LSGRLLFAGYDDFNCNVWDSMK 301
+G + A D + V D K
Sbjct: 493 AAGDKVGASASDGSVCVLDLRK 514
Score = 65.1 bits (157), Expect = 9e-11
Identities = 51/213 (23%), Positives = 84/213 (39%), Gaps = 37/213 (17%)
Query: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Q R +T +GH ++ A+ W LL S S D L +W N VH + + + T
Sbjct: 338 QDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTI 397
Query: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD 163
++P+G G +N + NL + ++S D
Sbjct: 398 KWSPTG-----PGTNNPNA--NLM-----------------------------LASASFD 421
Query: 164 TTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFT 223
+T LWD++ G H S+A SPD SG+ D +W+ + G ++
Sbjct: 422 STVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 481
Query: 224 GHESDINAICFFPNGEAICTGSDDASCRLFDLR 256
G I +C+ G+ + + D S + DLR
Sbjct: 482 G-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 90.9 bits (224), Expect = 1e-18
Identities = 48/188 (25%), Positives = 83/188 (44%)
Query: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
D N I+T D ++D + Q GHT S+ P +L S + DA+ ++W
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
Query: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICG 272
V +C Q HES + + G+ + + SDD D++ + L + E+ C
Sbjct: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
Query: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSW 332
+T F G + G D +WD + V GH ++ + + +G +AT +
Sbjct: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412
Query: 333 DSFLKIWN 340
DS +K+W+
Sbjct: 413 DSSVKLWD 420
Score = 79.0 bits (193), Expect = 6e-15
Identities = 64/253 (25%), Positives = 111/253 (43%), Gaps = 11/253 (4%)
Query: 65 TDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIY 124
+D+ +++ D ++V+D + + + + V + + PS + V D I+
Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
Query: 125 NLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHT 184
++ + V SA TG + +++SS D A DI+TG+ T T
Sbjct: 292 SVPNASCVQVVRAHESAVTGL---SLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348
Query: 185 GDCMSLAVS--PDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAIC 242
C PD +F +G D+ K+WD++E T F GH I +I F NG +
Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 408
Query: 243 TGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDD---FNCNVWDS 299
T +DD+S +L+DLR + ++ + S+ F SG L G D + C W
Sbjct: 409 TAADDSSVKLWDLRKLKNFKTLQLDNNF-EVKSLIFDQSGTYLALGGTDVQIYICKQWTE 467
Query: 300 MK--SERVGILSG 310
+ +E G+ +G
Sbjct: 468 ILHFTEHSGLTTG 480
Score = 71.6 bits (174), Expect = 9e-13
Identities = 56/231 (24%), Positives = 108/231 (46%), Gaps = 8/231 (3%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL+GH K+ ++ + L+ SAS D + +W + V + S V + +G
Sbjct: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIV-TSSGDTTCAL 168
+++ D + ++++ KV+ E S + L+C +F D I T + D+ +
Sbjct: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHPDGLIFGTGTMDSQIKI 376
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTF-TGHES 227
WD++ F GH+G S+A S + + A D+S KLWD+R+ +T +
Sbjct: 377 WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 436
Query: 228 DINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAF 278
++ ++ F +G + G D +++ + E++ F+ S + T VAF
Sbjct: 437 EVKSLIFDQSGTYLALGGTDV--QIYICKQWTEILHFTEHSGL--TTGVAF 483
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 90.5 bits (223), Expect = 2e-18
Identities = 52/205 (25%), Positives = 103/205 (50%), Gaps = 6/205 (2%)
Query: 139 LSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETG-QQKTVFVGHTGDCMSLAVSPDF 196
LS H G + CC+F + + + S+G D LW++ GH+G M L + D
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 197 NLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNG-EAICTGSDDASCRLFDL 255
++ S + D + +WD G + GH S +N+ G + +CTGSDD + +L+D+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 256 RADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 315
R + F + + +T F+ + + +G D + VWD +++ + GH + V
Sbjct: 182 RKKAAIQTFQNTYQVLAVT---FNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
Query: 316 SCLGVTADGMAVATGSWDSFLKIWN 340
+ L ++++G + + + D+ +++W+
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWD 263
Score = 90.1 bits (222), Expect = 3e-18
Identities = 70/254 (27%), Positives = 116/254 (45%), Gaps = 22/254 (8%)
Query: 100 VMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVT 159
V C + P+G+ +A G D + ++N+ G+ L H+G + + D +++
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVY---GDCDNYATLKGHSGAVMELHYNTDGSMLF 125
Query: 160 S-SGDTTCALWDIETGQQKTVFVGHTG---DCMSLAVSPDFNLFISGACDASAKLWDVRE 215
S S D T A+WD ETG++ GHT C P L +G+ D + KLWD+R+
Sbjct: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRK 183
Query: 216 GTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITS 275
QTF + + A+ F + I +G D +++DLR Q + ++ +T
Sbjct: 184 KAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR--QNKLTYTMRGHADSVTG 240
Query: 276 VAFSLSGRLLFAGYDDFNCNVWD----SMKSERVGILSGH-----DNRVSCLGVTADGMA 326
++ S G L + D VWD + K V I G+ N + C + DG
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDGSK 299
Query: 327 VATGSWDSFLKIWN 340
+A GS D F+ +W+
Sbjct: 300 IAAGSADRFVYVWD 313
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/214 (27%), Positives = 100/214 (46%), Gaps = 13/214 (6%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL+GH + +H+ TD +L SAS D + VWDS T +V + +S+V +C A G
Sbjct: 104 TLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRG 163
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCAL 168
+ C G D+ +K + K + + +T + F D ++ + S G D +
Sbjct: 164 PQLVCTGSDD----GTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKV 219
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR----EGTCRQTFTG 224
WD+ + GH L++S + + +S A D + ++WDVR + C + F G
Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG 279
Query: 225 H----ESDINAICFFPNGEAICTGSDDASCRLFD 254
+ E ++ + P+G I GS D ++D
Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Score = 76.6 bits (187), Expect = 3e-14
Identities = 70/300 (23%), Positives = 124/300 (41%), Gaps = 24/300 (8%)
Query: 51 LRGHLAKIYAMHWATDSKLLVSASQDGKLIVW------DSYTTNKVHAIPLRSSWVMTCA 104
L GH ++Y + + L SA D +++W D+Y T K H S VM
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGH-----SGAVMELH 116
Query: 105 YAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCC--RFLDDNNIVTSSG 162
Y G+ + D ++++ ++ E +V R L HT +++ C + T S
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGE---RVKR-LKGHTSFVNSCYPARRGPQLVCTGSD 172
Query: 163 DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTF 222
D T LWDI F +T +++ + + ISG D K+WD+R+ T
Sbjct: 173 DGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM 231
Query: 223 TGHESDINAICFFPNGEAICTGSDDASCRLFDLR--ADQE----LICFSHESIICGITSV 276
GH + + G + + + D + R++D+R A +E + + + +
Sbjct: 232 RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291
Query: 277 AFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFL 336
++S G + AG D VWD+ + L GH ++ + D + + S D L
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 42.0 bits (97), Expect = 8e-04
Identities = 32/164 (19%), Positives = 68/164 (41%), Gaps = 7/164 (4%)
Query: 57 KIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGG 116
++ A+ + S ++S D + VWD + + + V + + G+++
Sbjct: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254
Query: 117 LDNMCSIYNLKS---REGNVKVSRELSAHT---GYLSCCRFLDDNNIVTSSGDTTCALWD 170
+DN +++++ +E VK+ + + H L C D + I S D +WD
Sbjct: 255 MDNTVRVWDVRPFAPKERCVKIFQG-NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 171 IETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
+ + GH G +A PD + IS + D + +++
Sbjct: 314 TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 41.6 bits (96), Expect = 0.001
Identities = 28/129 (21%), Positives = 55/129 (42%), Gaps = 18/129 (13%)
Query: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD-----------SYTTNKVHA 92
Q + T+RGH + + +++ L+S + D + VWD VH
Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
Query: 93 IPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL 152
++ C+++P G+ +A G D +++ SR ++ +L H G ++ F
Sbjct: 284 FEKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSR----RILYKLPGHAGSINEVAFH 336
Query: 153 DDNNIVTSS 161
D I+ S+
Sbjct: 337 PDEPIIISA 345
Score = 30.4 bits (67), Expect = 2.4
Identities = 11/34 (32%), Positives = 19/34 (55%)
Query: 307 ILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
+LSGH+ V C +G +A+ +D + +WN
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 94
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/248 (26%), Positives = 112/248 (45%), Gaps = 14/248 (5%)
Query: 97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156
+ W+ C + PSG+ +A D +++L +G+ ++ E H+ + C + N
Sbjct: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLC--KGDCILTFE--GHSRAVWSCTWHSCGN 449
Query: 157 IVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVRE 215
V SS D T +WD+ + + + GHT S+ P N ++ + D + +WD R
Sbjct: 450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDART 509
Query: 216 GTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT- 274
G C Q+ GH IN F P G I + +L+D R ++ SI G +
Sbjct: 510 GICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIV-----SIDIGPSP 564
Query: 275 --SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSW 332
V F SGR+L + ++ D +KS + L GH+N + + DG + +G
Sbjct: 565 GNEVNFDSSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGS 623
Query: 333 DSFLKIWN 340
D ++ W+
Sbjct: 624 DGTVRTWS 631
Score = 77.0 bits (188), Expect = 2e-14
Identities = 62/231 (26%), Positives = 96/231 (41%), Gaps = 12/231 (5%)
Query: 70 LVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSR 129
L ++S D + +WD + + S V +C + GNFVA LD I+++ S
Sbjct: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468
Query: 130 EGNVKVSRELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCM 188
+ L HT ++ F N ++TSS D T ++WD TG + GH
Sbjct: 469 ----RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIN 524
Query: 189 SLAVSPDFNLFISGACDAS--AKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSD 246
P ++ S CDA KLWD R+ + S N + F +G + S
Sbjct: 525 DAIFDPRGHMIAS--CDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASG 582
Query: 247 DASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVW 297
+ L DL++ + HE+ +V FS G +LF+G D W
Sbjct: 583 NGVIHLLDLKSGEIHKLMGHEN---EAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 52.4 bits (124), Expect = 6e-07
Identities = 44/220 (20%), Positives = 87/220 (39%), Gaps = 9/220 (4%)
Query: 125 NLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFV--- 181
+L + + K+ H +SC +I+ S G+ LW + + V +
Sbjct: 334 SLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR--LWKVLGLPKCNVLLTGF 391
Query: 182 GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAI 241
GHT P + + + D + KLWD+ +G C TF GH + + + G +
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
Query: 242 CTGSDDASCRLFDLRADQ-ELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
+ S D + +++D+ +++ + H + S+ F L D ++WD+
Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTD---SVNSIEFFPFSNTLLTSSADKTLSIWDAR 508
Query: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
L GH + ++ G +A+ K+W+
Sbjct: 509 TGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Score = 40.4 bits (93), Expect = 0.002
Identities = 33/168 (19%), Positives = 71/168 (42%), Gaps = 8/168 (4%)
Query: 46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105
R R TL GH + ++ + S L+++S D L +WD+ T ++ + +
Sbjct: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIF 528
Query: 106 APSGNFVACGGLDNMCSIYNLKSREG--NVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD 163
P G+ +A + +++ + ++ + + S R L +SG+
Sbjct: 529 DPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVL-----AQASGN 583
Query: 164 TTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLW 211
L D+++G+ + +GH + ++ S D + SG D + + W
Sbjct: 584 GVIHLLDLKSGEIHKL-MGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 89.7 bits (221), Expect = 3e-18
Identities = 53/200 (26%), Positives = 95/200 (47%), Gaps = 5/200 (2%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
+L GH + + ++ T +L+V+ SQ G + VWD + + + + + + P G
Sbjct: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCAL 168
FVA G D +++++ R+G V R H+ + C RF D + S+ D T L
Sbjct: 118 EFVASGSQDTNIKLWDIR-RKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKL 173
Query: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
WD+ G+ + F GHTG + P+ L SG+ D + + WD+ + G
Sbjct: 174 WDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGP 233
Query: 229 INAICFFPNGEAICTGSDDA 248
+ ++ F P+G + +G D+
Sbjct: 234 VRSVLFNPDGCCLYSGCQDS 253
Score = 85.1 bits (209), Expect = 8e-17
Identities = 61/228 (26%), Positives = 103/228 (45%), Gaps = 7/228 (3%)
Query: 108 SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSGDTTC 166
SG +A GG D +++++ + N +S L+ HT + R + IV S +
Sbjct: 32 SGRLLATGGDDCRVNLWSIN--KPNCIMS--LTGHTSPVESVRLNTPEELIVAGSQSGSI 87
Query: 167 ALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHE 226
+WD+E + +GH + SL P SG+ D + KLWD+R C + GH
Sbjct: 88 RVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHS 147
Query: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLF 286
+ + F P+G+ + + +DD + +L+DL A + + F + + V F + LL
Sbjct: 148 QAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT--GPVNVVEFHPNEYLLA 205
Query: 287 AGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDS 334
+G D WD K + V + G V + DG + +G DS
Sbjct: 206 SGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
Score = 82.8 bits (203), Expect = 4e-16
Identities = 60/225 (26%), Positives = 93/225 (41%), Gaps = 7/225 (3%)
Query: 68 KLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLK 127
+LL + D ++ +W N + ++ +S V + + G +++L+
Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 128 SREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCALWDIETGQQKTVFVGHTGD 186
+ K+ R L H + F V S S DT LWDI + GH+
Sbjct: 94 A----AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQA 149
Query: 187 CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSD 246
L SPD S A D + KLWD+ G F GH +N + F PN + +GS
Sbjct: 150 VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSS 209
Query: 247 DASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDD 291
D + R +DL Q + C E + SV F+ G L++G D
Sbjct: 210 DRTIRFWDLEKFQVVSCIEGEP--GPVRSVLFNPDGCCLYSGCQD 252
Score = 81.6 bits (200), Expect = 9e-16
Identities = 45/184 (24%), Positives = 85/184 (46%), Gaps = 2/184 (1%)
Query: 157 IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
+ T D LW I GHT S+ ++ L ++G+ S ++WD+
Sbjct: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSV 276
+T GH+++I ++ F P GE + +GS D + +L+D+R ++ F + + +
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR--RKGCVFRYRGHSQAVRCL 153
Query: 277 AFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFL 336
FS G+ L + DD +WD + + GH V+ + + +A+GS D +
Sbjct: 154 RFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213
Query: 337 KIWN 340
+ W+
Sbjct: 214 RFWD 217
Score = 73.9 bits (180), Expect = 2e-13
Identities = 47/162 (29%), Positives = 73/162 (45%), Gaps = 5/162 (3%)
Query: 181 VGHTGDCMSLAVSP-DFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGE 239
V H + SL + L +G D LW + + C + TGH S + ++ E
Sbjct: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEE 76
Query: 240 AICTGSDDASCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD 298
I GS S R++DL A + L H++ IC S+ F G + +G D N +WD
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC---SLDFHPYGEFVASGSQDTNIKLWD 133
Query: 299 SMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
+ V GH V CL + DG +A+ + D +K+W+
Sbjct: 134 IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Score = 61.6 bits (148), Expect = 1e-09
Identities = 43/159 (27%), Positives = 70/159 (44%), Gaps = 5/159 (3%)
Query: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
RTL GH A I ++ + + + S SQD + +WD V S V ++P
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD 158
Query: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
G ++A D+ +++L + K+ E HTG ++ F + ++ S S D T
Sbjct: 159 GKWLASAADDHTVKLWDLTAG----KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
Query: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDA 206
WD+E Q + G G S+ +PD SG D+
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 89.4 bits (220), Expect = 4e-18
Identities = 80/333 (24%), Positives = 147/333 (44%), Gaps = 40/333 (12%)
Query: 37 LEVVGRVQMRTRRT--LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD------SYTTN 88
+E+ G V++ + + LRGH ++++ W S LL S S D +W+ +T
Sbjct: 161 MEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQ 220
Query: 89 KV---------HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSREL 139
V H +P V + + +G +A G D I+ + +GN+ + L
Sbjct: 221 LVLRHCIREGGHDVPSNKD-VTSLDWNTNGTLLATGSYDGFARIW---TEDGNL--ASTL 274
Query: 140 SAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL 198
H G + ++ N + S+G D T +WD TG+ K F H+ + + N
Sbjct: 275 GQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NN 331
Query: 199 FISGACDASAKLWDVREGTCR--QTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLR 256
+C + R G R +TF GH +++NAI + P+G + + SDD + +++ ++
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 391
Query: 257 ADQELICFSHESIICGITSVAFSLSGR---------LLFAGYDDFNCNVWDSMKSERVGI 307
QE+ ++ I ++ +S +G +L + D +WD +
Sbjct: 392 --QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHT 449
Query: 308 LSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
L+ H V + + DG +A+GS+D + IWN
Sbjct: 450 LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482
Score = 75.9 bits (185), Expect = 5e-14
Identities = 56/262 (21%), Positives = 110/262 (41%), Gaps = 18/262 (6%)
Query: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D I+WD++T P S+ + + +
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCAL 168
F +C +MC R G + + HT ++ ++ ++ S S D T +
Sbjct: 333 TFASCS--TDMCIHV---CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 387
Query: 169 WDIET--------GQQKTVFVGHTGDCMSLAVSPDFNLFISGAC-DASAKLWDVREGTCR 219
W ++ K ++ +P+ N+ ++ A D++ +LWD+ G C
Sbjct: 388 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 447
Query: 220 QTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFS 279
T T H+ + ++ F P+G+ + +GS D +++ ++ + + GI V ++
Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFEVCWN 504
Query: 280 LSGRLLFAGYDDFNCNVWDSMK 301
G + A D + V D K
Sbjct: 505 ARGDKVGASASDGSVCVLDLRK 526
Score = 64.3 bits (155), Expect = 1e-10
Identities = 47/211 (22%), Positives = 79/211 (37%), Gaps = 37/211 (17%)
Query: 46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105
R +T +GH ++ A+ W LL S S D L +W +H + + + T +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 106 APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165
+P+G + + M + ++S D+T
Sbjct: 412 SPTGPATSNPNSNIM------------------------------------LASASFDST 435
Query: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225
LWDIE G H S+A SPD SG+ D +W+ + G ++ G
Sbjct: 436 VRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG- 494
Query: 226 ESDINAICFFPNGEAICTGSDDASCRLFDLR 256
I +C+ G+ + + D S + DLR
Sbjct: 495 TGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,620,838
Number of Sequences: 37866
Number of extensions: 530533
Number of successful extensions: 4568
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 231
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 1536
Number of HSP's gapped (non-prelim): 1471
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.