BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sapiens] (384 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa... 761 0.0 gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 249 3e-66 gi|13540517 endothelial differentiation, sphingolipid G-protein-... 245 6e-65 gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 244 9e-65 gi|134244587 endothelial differentiation, sphingolipid G-protein... 205 5e-53 gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 181 8e-46 gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 169 4e-42 gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 169 4e-42 gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 161 1e-39 gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 119 6e-27 gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 119 6e-27 gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 119 6e-27 gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 119 6e-27 gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 119 6e-27 gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 119 6e-27 gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 108 6e-24 gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] 103 2e-22 gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 96 7e-20 gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 90 4e-18 gi|5921992 adenosine A2a receptor [Homo sapiens] 82 1e-15 gi|5174535 melanocortin 5 receptor [Homo sapiens] 81 2e-15 gi|71999131 opsin 3 [Homo sapiens] 74 2e-13 gi|4506527 rhodopsin [Homo sapiens] 73 5e-13 gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 72 6e-13 gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 72 6e-13 gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 72 6e-13 gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 72 6e-13 gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 72 6e-13 gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 72 6e-13 gi|119508433 melanocortin 4 receptor [Homo sapiens] 72 1e-12 >gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sapiens] Length = 384 Score = 761 bits (1966), Expect = 0.0 Identities = 384/384 (100%), Positives = 384/384 (100%) Query: 1 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV 60 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV Sbjct: 1 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV 60 Query: 61 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL 120 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL Sbjct: 61 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL 120 Query: 121 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP 180 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP Sbjct: 121 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP 180 Query: 181 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP 240 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP Sbjct: 181 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP 240 Query: 241 AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS 300 AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS Sbjct: 241 AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS 300 Query: 301 AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS 360 AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS Sbjct: 301 AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS 360 Query: 361 FRGSRSLSFRMREPLSSISSVRSI 384 FRGSRSLSFRMREPLSSISSVRSI Sbjct: 361 FRGSRSLSFRMREPLSSISSVRSI 384 >gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] Length = 378 Score = 249 bits (636), Expect = 3e-66 Identities = 141/333 (42%), Positives = 196/333 (58%), Gaps = 5/333 (1%) Query: 28 HYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVN 87 HY + G+LAGR G L + +VLENL+VL AI + + +Y+ + N Sbjct: 21 HYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGN 80 Query: 88 ITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATM 147 + L DLL G AY N+L+SG +TF L+P WFLREG +F AL AST SLL A ER TM Sbjct: 81 LALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTM 140 Query: 148 VRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILF 207 ++ + A K RV+ IG+CWL+A LG LP+LGWNCL CS++LPLYSK+YI F Sbjct: 141 IK-MRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAF 199 Query: 208 CLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPL 267 C+ IF +L TI+ LY I+ LV++S +K ++ LL+TV++++ F+ CW PL Sbjct: 200 CISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPL 259 Query: 268 FGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCL 327 F L L DV + A L W + LAVLNSA+NP+IY+ S+E+ RA L C CL Sbjct: 260 FILFLIDV-ACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFR-LVCNCL 317 Query: 328 RLGMRGPGDCLARAVE--AHSGASTTDSSLRPR 358 G + A++ +S+ +SS P+ Sbjct: 318 VRGRGARASPIQPALDPSRSKSSSSNNSSHSPK 350 >gi|13540517 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 [Homo sapiens] Length = 398 Score = 245 bits (625), Expect = 6e-65 Identities = 152/342 (44%), Positives = 198/342 (57%), Gaps = 22/342 (6%) Query: 22 SRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWV 81 S +IVLHYN++G+L G GL A + +A +VLENL VL + H R + Sbjct: 12 SEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPM 71 Query: 82 YYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAG 141 + L ++TLSDLL GAAY AN+LLSG T +L+PA WF REG +F AL AS SLL A Sbjct: 72 FLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIAL 131 Query: 142 ERFATMVR----PVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLL 197 ER TM R PV+ G R W ++ LLG+LP LGWNCL D CS++L Sbjct: 132 ERSLTMARRGPAPVSSRG-----RTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVL 186 Query: 198 PLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP-RPA--------ARRKAR- 247 PLY+K Y+LFC++ F G+LA I LY I+ V+A+ ++ P RP ARRK R Sbjct: 187 PLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRS 246 Query: 248 -RLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPII 306 LL+T+ ++LLAF+ CWGPLF LLL DV L+ D L LA+ NS +NPII Sbjct: 247 LALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQA-DPFLGLAMANSLLNPII 305 Query: 307 YSFRSREVCRAVLSFLCCGCLRLGMRGPG-DCLARAVEAHSG 347 Y+ +R++ A+L +CCG G G A A EA G Sbjct: 306 YTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGG 347 >gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] Length = 382 Score = 244 bits (623), Expect = 9e-65 Identities = 133/334 (39%), Positives = 199/334 (59%), Gaps = 11/334 (3%) Query: 1 MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV 60 M T P+ ++ + +IV HYN++G+L ++ + + + C + Sbjct: 1 MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKL-NISADKENSIKLTSVVFILICCFI 59 Query: 61 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL 120 +LEN+ VL I + R +YY + N+ LSDLL G AY AN+LLSGA T++L PAQWFL Sbjct: 60 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFL 119 Query: 121 REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP 180 REG +F AL+AS FSLL A ER+ TM++ +G + R++ I CW+++ +LG LP Sbjct: 120 REGSMFVALSASVFSLLAIAIERYITMLKMKLHNG-SNNFRLFLLISACWVISLILGGLP 178 Query: 181 LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQK---- 236 ++GWNC+ A CS++LPLY K YILFC +F +L +I+ LY I+ LV+ ++ Sbjct: 179 IMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFR 238 Query: 237 ---APRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWIL 293 + + K+ LLKTV+++L F+ CW PLF LLL DV G + + L ++ L Sbjct: 239 KNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV-GCKVKTCDILFRAEYFL 297 Query: 294 ALAVLNSAVNPIIYSFRSREVCRAVLSFL-CCGC 326 LAVLNS NPIIY+ ++E+ RA + + CC C Sbjct: 298 VLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKC 331 >gi|134244587 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Homo sapiens] Length = 353 Score = 205 bits (522), Expect = 5e-53 Identities = 117/280 (41%), Positives = 170/280 (60%), Gaps = 6/280 (2%) Query: 54 VAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRL 113 V C +V+ENLLVL A+ + + +Y L N+ SDLL G A++AN LLSG+ T RL Sbjct: 41 VILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRL 100 Query: 114 APAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLA 173 P QWF REG F L+AS FSLL A ER + + V G+ K+ R+ IG WL++ Sbjct: 101 TPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAK-VKLYGSDKSCRMLLLIGASWLIS 159 Query: 174 ALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQAS 233 +LG LP+LGWNCL + CS++LPLY+K Y+L + IF+ +L I+ LY I+ +V++S Sbjct: 160 LVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSS 219 Query: 234 GQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWIL 293 P + LLKTV ++L F+VCW P F +LL D + + + L + Sbjct: 220 HADMAAP----QTLALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVHSCPILYKAHYFF 274 Query: 294 ALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRG 333 A++ LNS +NP+IY++RSR++ R VL L C +G++G Sbjct: 275 AVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQG 314 >gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] Length = 351 Score = 181 bits (460), Expect = 8e-46 Identities = 129/336 (38%), Positives = 181/336 (53%), Gaps = 15/336 (4%) Query: 21 HSRLIVLHYNHSGR-LAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRR 79 ++ I YN+SG+ L+ P+D + AL GL+V S LV+L NLLV+AAI S+ R + Sbjct: 9 YNETIGFFYNNSGKELSSHWRPKDVVVVAL-GLTV--SVLVLLTNLLVIAAIASNRRFHQ 65 Query: 80 WVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFT 139 +YY L N+ +DL G AYL + +G RT RL+ WFLR+GLL T+L AS +LL Sbjct: 66 PIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAI 125 Query: 140 AGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPL 199 A ER +++ S + V +G+ W+ A LG+LP W+CLCA DRCS + PL Sbjct: 126 AVERHRSVMAVQLHSRLPRGRVVMLIVGV-WVAALGLGLLPAHSWHCLCALDRCSRMAPL 184 Query: 200 YSKRYI----LFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP-RPAARRKARRLLKTVL 254 S+ Y+ L L++F ++A ++ + R VQ + P R L+KTV+ Sbjct: 185 LSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVV 244 Query: 255 MILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREV 314 +IL AF+VCW P +LL D G + L + L LA NS VN +YS R E+ Sbjct: 245 IILGAFVVCWTPGQVVLLLDGLGCE--SCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEM 302 Query: 315 CRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGAST 350 R LCC CLR R + + A GAST Sbjct: 303 RRTFRRLLCCACLRQSTR---ESVHYTSSAQGGAST 335 >gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 169 bits (428), Expect = 4e-42 Identities = 104/309 (33%), Positives = 157/309 (50%), Gaps = 11/309 (3%) Query: 21 HSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRW 80 ++ I YN SG+ L + GL + ++L NLLV+ AI + R Sbjct: 26 YNESIAFFYNRSGKHLATEWNTVSKL--VMGLGITVCIFIMLANLLVMVAIYVNRRFHFP 83 Query: 81 VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTA 140 +YY + N+ +D G AY + +G T RL + W LR+GL+ T+L AS +LL A Sbjct: 84 IYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIA 143 Query: 141 GERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLY 200 ER T+ R + RV I + W +A ++G +P +GWNC+C + CS++ PLY Sbjct: 144 IERHITVFRMQLHT-RMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLY 202 Query: 201 SKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARR-----LLKTVLM 255 S Y++F + ++ LY IF V+ + R ++ + R LLKTV++ Sbjct: 203 SDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVI 262 Query: 256 ILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVC 315 +L AF++CW P LLL DV Y + + L LA NSA+NPIIYS+R +E+ Sbjct: 263 VLGAFIICWTPGLVLLLLDVCCPQCDVLAYEK---FFLLLAEFNSAMNPIIYSYRDKEMS 319 Query: 316 RAVLSFLCC 324 LCC Sbjct: 320 ATFRQILCC 328 >gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 169 bits (428), Expect = 4e-42 Identities = 104/309 (33%), Positives = 157/309 (50%), Gaps = 11/309 (3%) Query: 21 HSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRW 80 ++ I YN SG+ L + GL + ++L NLLV+ AI + R Sbjct: 26 YNESIAFFYNRSGKHLATEWNTVSKL--VMGLGITVCIFIMLANLLVMVAIYVNRRFHFP 83 Query: 81 VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTA 140 +YY + N+ +D G AY + +G T RL + W LR+GL+ T+L AS +LL A Sbjct: 84 IYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIA 143 Query: 141 GERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLY 200 ER T+ R + RV I + W +A ++G +P +GWNC+C + CS++ PLY Sbjct: 144 IERHITVFRMQLHT-RMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLY 202 Query: 201 SKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARR-----LLKTVLM 255 S Y++F + ++ LY IF V+ + R ++ + R LLKTV++ Sbjct: 203 SDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVI 262 Query: 256 ILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVC 315 +L AF++CW P LLL DV Y + + L LA NSA+NPIIYS+R +E+ Sbjct: 263 VLGAFIICWTPGLVLLLLDVCCPQCDVLAYEK---FFLLLAEFNSAMNPIIYSYRDKEMS 319 Query: 316 RAVLSFLCC 324 LCC Sbjct: 320 ATFRQILCC 328 >gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] Length = 353 Score = 161 bits (407), Expect = 1e-39 Identities = 97/273 (35%), Positives = 148/273 (54%), Gaps = 9/273 (3%) Query: 58 CLVVL-ENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPA 116 CL + N LV+AA+ + + YY L N+ +D G AY+ + +G + L Sbjct: 41 CLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVN 100 Query: 117 QWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALL 176 +WFLR+GLL ++L AS +LL A ER +++R S TK RV I L W +A + Sbjct: 101 RWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTK-KRVTLLILLVWAIAIFM 159 Query: 177 GMLPLLGWNCLCAFDRCSSLLPLYSKRYILFC----LVIFAGVLATIMGLYGAIFRLVQA 232 G +P LGWNCLC CSSL P+YS+ Y++F L+ F ++ + +Y + R Sbjct: 160 GAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNV 219 Query: 233 -SGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW 291 S + + RR +L+KTV+ +L AF+VCW P +LL D ++++ W Sbjct: 220 LSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVK--RW 277 Query: 292 ILALAVLNSAVNPIIYSFRSREVCRAVLSFLCC 324 L LA+LNS VNPIIYS++ ++ + +CC Sbjct: 278 FLLLALLNSVVNPIIYSYKDEDMYGTMKKMICC 310 >gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 119 bits (297), Expect = 6e-27 Identities = 96/330 (29%), Positives = 159/330 (48%), Gaps = 34/330 (10%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRW--VYYCLVNITLSDLLTGAAYLANVLL 105 A+ LS+ VLENLLVL I H RS R Y+ + ++ ++DLL ++ + + Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVIL-HSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 176 Query: 106 SGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGF 165 + + + + G + + AS SL TA +R+ ++ RP+A + Sbjct: 177 FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 236 Query: 166 IGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGA 225 L W +A ++ +LPLLGWNC CS + P + Y++F + + + +L I+ Y Sbjct: 237 FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 296 Query: 226 IF--------RLVQASGQKA-------------PRPAARRKARRLLKTVLMILLAFLVCW 264 I R++Q QK+ RP R RL KT+++IL+ ++CW Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 Query: 265 GPLFGLLLADVFGSNLWAQEYLRGM-DWILALAVLNSAVNPIIYSFRSREVCRAVLSFL- 322 GPL +++ DVFG + ++ + + L +LNS VNPIIY+ RS+++ A S Sbjct: 357 GPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 413 Query: 323 -CCGCLRL--GMRGPGDCLARAVEAHSGAS 349 C G + G DCL + A++ AS Sbjct: 414 SCEGTAQPLDNSMGDSDCLHK--HANNAAS 441 >gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 119 bits (297), Expect = 6e-27 Identities = 96/330 (29%), Positives = 159/330 (48%), Gaps = 34/330 (10%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRW--VYYCLVNITLSDLLTGAAYLANVLL 105 A+ LS+ VLENLLVL I H RS R Y+ + ++ ++DLL ++ + + Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVIL-HSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 176 Query: 106 SGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGF 165 + + + + G + + AS SL TA +R+ ++ RP+A + Sbjct: 177 FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 236 Query: 166 IGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGA 225 L W +A ++ +LPLLGWNC CS + P + Y++F + + + +L I+ Y Sbjct: 237 FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 296 Query: 226 IF--------RLVQASGQKA-------------PRPAARRKARRLLKTVLMILLAFLVCW 264 I R++Q QK+ RP R RL KT+++IL+ ++CW Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 Query: 265 GPLFGLLLADVFGSNLWAQEYLRGM-DWILALAVLNSAVNPIIYSFRSREVCRAVLSFL- 322 GPL +++ DVFG + ++ + + L +LNS VNPIIY+ RS+++ A S Sbjct: 357 GPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 413 Query: 323 -CCGCLRL--GMRGPGDCLARAVEAHSGAS 349 C G + G DCL + A++ AS Sbjct: 414 SCEGTAQPLDNSMGDSDCLHK--HANNAAS 441 >gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 119 bits (297), Expect = 6e-27 Identities = 96/330 (29%), Positives = 159/330 (48%), Gaps = 34/330 (10%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRW--VYYCLVNITLSDLLTGAAYLANVLL 105 A+ LS+ VLENLLVL I H RS R Y+ + ++ ++DLL ++ + + Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVIL-HSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 176 Query: 106 SGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGF 165 + + + + G + + AS SL TA +R+ ++ RP+A + Sbjct: 177 FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 236 Query: 166 IGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGA 225 L W +A ++ +LPLLGWNC CS + P + Y++F + + + +L I+ Y Sbjct: 237 FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 296 Query: 226 IF--------RLVQASGQKA-------------PRPAARRKARRLLKTVLMILLAFLVCW 264 I R++Q QK+ RP R RL KT+++IL+ ++CW Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 Query: 265 GPLFGLLLADVFGSNLWAQEYLRGM-DWILALAVLNSAVNPIIYSFRSREVCRAVLSFL- 322 GPL +++ DVFG + ++ + + L +LNS VNPIIY+ RS+++ A S Sbjct: 357 GPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 413 Query: 323 -CCGCLRL--GMRGPGDCLARAVEAHSGAS 349 C G + G DCL + A++ AS Sbjct: 414 SCEGTAQPLDNSMGDSDCLHK--HANNAAS 441 >gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 119 bits (297), Expect = 6e-27 Identities = 96/330 (29%), Positives = 159/330 (48%), Gaps = 34/330 (10%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRW--VYYCLVNITLSDLLTGAAYLANVLL 105 A+ LS+ VLENLLVL I H RS R Y+ + ++ ++DLL ++ + + Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVIL-HSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 176 Query: 106 SGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGF 165 + + + + G + + AS SL TA +R+ ++ RP+A + Sbjct: 177 FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 236 Query: 166 IGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGA 225 L W +A ++ +LPLLGWNC CS + P + Y++F + + + +L I+ Y Sbjct: 237 FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 296 Query: 226 IF--------RLVQASGQKA-------------PRPAARRKARRLLKTVLMILLAFLVCW 264 I R++Q QK+ RP R RL KT+++IL+ ++CW Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 Query: 265 GPLFGLLLADVFGSNLWAQEYLRGM-DWILALAVLNSAVNPIIYSFRSREVCRAVLSFL- 322 GPL +++ DVFG + ++ + + L +LNS VNPIIY+ RS+++ A S Sbjct: 357 GPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 413 Query: 323 -CCGCLRL--GMRGPGDCLARAVEAHSGAS 349 C G + G DCL + A++ AS Sbjct: 414 SCEGTAQPLDNSMGDSDCLHK--HANNAAS 441 >gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 119 bits (297), Expect = 6e-27 Identities = 96/330 (29%), Positives = 159/330 (48%), Gaps = 34/330 (10%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRW--VYYCLVNITLSDLLTGAAYLANVLL 105 A+ LS+ VLENLLVL I H RS R Y+ + ++ ++DLL ++ + + Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVIL-HSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 176 Query: 106 SGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGF 165 + + + + G + + AS SL TA +R+ ++ RP+A + Sbjct: 177 FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 236 Query: 166 IGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGA 225 L W +A ++ +LPLLGWNC CS + P + Y++F + + + +L I+ Y Sbjct: 237 FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 296 Query: 226 IF--------RLVQASGQKA-------------PRPAARRKARRLLKTVLMILLAFLVCW 264 I R++Q QK+ RP R RL KT+++IL+ ++CW Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 Query: 265 GPLFGLLLADVFGSNLWAQEYLRGM-DWILALAVLNSAVNPIIYSFRSREVCRAVLSFL- 322 GPL +++ DVFG + ++ + + L +LNS VNPIIY+ RS+++ A S Sbjct: 357 GPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 413 Query: 323 -CCGCLRL--GMRGPGDCLARAVEAHSGAS 349 C G + G DCL + A++ AS Sbjct: 414 SCEGTAQPLDNSMGDSDCLHK--HANNAAS 441 >gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] Length = 439 Score = 119 bits (297), Expect = 6e-27 Identities = 96/330 (29%), Positives = 159/330 (48%), Gaps = 34/330 (10%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRW--VYYCLVNITLSDLLTGAAYLANVLL 105 A+ LS+ VLENLLVL I H RS R Y+ + ++ ++DLL ++ + + Sbjct: 85 AIAVLSLTLGTFTVLENLLVLCVIL-HSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 143 Query: 106 SGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGF 165 + + + + G + + AS SL TA +R+ ++ RP+A + Sbjct: 144 FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 203 Query: 166 IGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGA 225 L W +A ++ +LPLLGWNC CS + P + Y++F + + + +L I+ Y Sbjct: 204 FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 263 Query: 226 IF--------RLVQASGQKA-------------PRPAARRKARRLLKTVLMILLAFLVCW 264 I R++Q QK+ RP R RL KT+++IL+ ++CW Sbjct: 264 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 323 Query: 265 GPLFGLLLADVFGSNLWAQEYLRGM-DWILALAVLNSAVNPIIYSFRSREVCRAVLSFL- 322 GPL +++ DVFG + ++ + + L +LNS VNPIIY+ RS+++ A S Sbjct: 324 GPLLAIMVYDVFGK---MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 380 Query: 323 -CCGCLRL--GMRGPGDCLARAVEAHSGAS 349 C G + G DCL + A++ AS Sbjct: 381 SCEGTAQPLDNSMGDSDCLHK--HANNAAS 408 >gi|4885325 G protein-coupled receptor 3 [Homo sapiens] Length = 330 Score = 108 bits (271), Expect = 6e-24 Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 21/276 (7%) Query: 59 LVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQW 118 LV EN LV+A I R ++ + ++ ++DLL G ++L A F + A+ Sbjct: 53 LVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLG----LVLHFAAVFCIGSAEM 108 Query: 119 FL-REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLG 177 L G+L A AS SLL +R+ ++ + T +R Y + L W A LG Sbjct: 109 SLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLG 168 Query: 178 MLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLV-----QA 232 +LP+L WNCL C + PL SK +++ + F V ++ LY I R+V Q Sbjct: 169 LLPVLAWNCLDGLTTCGVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQI 227 Query: 233 SGQKAPRPAARRKA-RRLLKTVLMILLAFLVCWGPL-FGLLLADVFGSNLWAQEYLRGMD 290 + Q+ PA+ A R+ + T+ ++L AF CW P LL D L+ YL Sbjct: 228 ALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYT--YL---- 281 Query: 291 WILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGC 326 L A NS +NPIIY+FR+++V + VL +CC C Sbjct: 282 -TLLPATYNSMINPIIYAFRNQDV-QKVLWAVCCCC 315 >gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] Length = 360 Score = 103 bits (258), Expect = 2e-22 Identities = 83/281 (29%), Positives = 133/281 (47%), Gaps = 23/281 (8%) Query: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSG 107 A+ L L LEN+ VL I S + RR Y + L GA +LA+V+ + Sbjct: 35 AVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGS-----LAGADFLASVVFAC 89 Query: 108 ART-FRL-----APAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSR 161 + F + + A + L+ G + AS SLL TA +R+ + P + R Sbjct: 90 SFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGR 149 Query: 162 VYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMG 221 +G+ W+L+AL+ LPL+GW C C CS L PL Y+L L+ A + + I+ Sbjct: 150 ALVTLGIMWVLSALVSYLPLMGWTC-CP-RPCSELFPLIPNDYLLSWLLFIAFLFSGIIY 207 Query: 222 LYGAIF-----RLVQASG---QKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLA 273 YG + + SG ++ P A R RL KT+ ++L L+CW P+ L+ Sbjct: 208 TYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAH 267 Query: 274 DVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREV 314 + + + + + + L ++NS VNP+IY+ RS E+ Sbjct: 268 SL--ATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEI 306 >gi|4885295 G protein-coupled receptor 12 [Homo sapiens] Length = 334 Score = 95.5 bits (236), Expect = 7e-20 Identities = 75/289 (25%), Positives = 132/289 (45%), Gaps = 23/289 (7%) Query: 59 LVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQW 118 L+ EN +V+ I + R ++ + ++ L+DLL G + N + + + A Sbjct: 57 LISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA---YLLQSEATK 113 Query: 119 FLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGM 178 + GL+ + +AS SLL +R+ ++ + + Y + + W + LG+ Sbjct: 114 LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGL 173 Query: 179 LPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP 238 LP++GWNCL CS + PL +K V F + A ++ LY I ++V + Sbjct: 174 LPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIA 232 Query: 239 ------RPAARRKARRLLKTVLMILLAFLVCWGPL-FGLLLADVFGSNLWAQEYLRGMDW 291 + R+ + T+ +IL F CW P L+AD +++ Sbjct: 233 LQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYA------- 285 Query: 292 ILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGM----RGPGD 336 L A NS +NP+IY+FR++E+ +A L +CCGC+ + R P D Sbjct: 286 TLLPATYNSIINPVIYAFRNQEIQKA-LCLICCGCIPSSLAQRARSPSD 333 >gi|4885341 G protein-coupled receptor 6 [Homo sapiens] Length = 362 Score = 89.7 bits (221), Expect = 4e-18 Identities = 79/285 (27%), Positives = 128/285 (44%), Gaps = 21/285 (7%) Query: 52 LSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTF 111 L + ++ EN LV+A I S R ++ + ++ +DLL G + + + Sbjct: 78 LLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQ----- 132 Query: 112 RLAPAQW--FLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLC 169 L P++ L G L + AAS SLL +R+ ++ + V+ + Sbjct: 133 YLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192 Query: 170 WLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRL 229 W ++ LG+LP+LGWNCL CS + PL ++ ++ F V ++ LY I ++ Sbjct: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPL-ARSHVALLSAAFFMVFGIMLHLYVRICQV 251 Query: 230 VQ------ASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQ 283 V A Q P R+ + T+ ++L F W P + V GS+ Sbjct: 252 VWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLP---FAIYCVVGSHEDPA 308 Query: 284 EYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLR 328 Y L A NS +NPIIY+FR++E+ RA L L CGC + Sbjct: 309 VYTYA---TLLPATYNSMINPIIYAFRNQEIQRA-LWLLLCGCFQ 349 >gi|5921992 adenosine A2a receptor [Homo sapiens] Length = 412 Score = 81.6 bits (200), Expect = 1e-15 Identities = 79/302 (26%), Positives = 128/302 (42%), Gaps = 59/302 (19%) Query: 52 LSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTF 111 + +A + L +L N+LV A+ + + Y +V++ +D+ G A F Sbjct: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVL---------AIPF 62 Query: 112 RLAPAQWFLR--EGLLFTAL------AASTFSLLFTAGERFATMVRPVAESGATKTSRVY 163 + + F G LF A +S FSLL A +R+ + P+ +G +R Sbjct: 63 AITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 Query: 164 GFIGLCWLLAALLGMLPLLGWN-------------------CLCAFDRCSSLLPLYSKRY 204 G I +CW+L+ +G+ P+LGWN C F+ ++P+ Y Sbjct: 123 GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFE---DVVPMNYMVY 179 Query: 205 ILFCLVIFAGVLATIMGLYGAIF-----RLVQASGQKAPRPAAR---RKARRLLKTVLMI 256 F + +L ++G+Y IF +L Q Q P AR +K K++ +I Sbjct: 180 FNFFACVLVPLL-LMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAII 238 Query: 257 LLAFLVCWGPL-----FGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRS 311 + F +CW PL F D + LW M + L+ NS VNP IY++R Sbjct: 239 VGLFALCWLPLHIINCFTFFCPDCSHAPLWL------MYLAIVLSHTNSVVNPFIYAYRI 292 Query: 312 RE 313 RE Sbjct: 293 RE 294 >gi|5174535 melanocortin 5 receptor [Homo sapiens] Length = 325 Score = 80.9 bits (198), Expect = 2e-15 Identities = 71/289 (24%), Positives = 128/289 (44%), Gaps = 32/289 (11%) Query: 61 VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTG-AAYLANVLLSGARTFRLAPAQWF 119 +LEN+LV+ AI + +Y+ + ++ ++D+L ++ + + L A F Sbjct: 51 LLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAF 110 Query: 120 LR------EGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLA 173 +R + ++ ++ AS SLL A +R+ T+ + R I W Sbjct: 111 VRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFC 170 Query: 174 ALLGMLPLLGWNCLCAFDRCSSLLPLYSKR-YILFCLV-IFAGVLATIMGLYGAIFRLVQ 231 C + LYS+ Y++ CL+ +F +L ++ LY +F L + Sbjct: 171 T-----------------GCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLAR 213 Query: 232 ASGQK-APRPAA----RRKARRLLKTVLMILLAFLVCWGPLF-GLLLADVFGSNLWAQEY 285 ++ A P A +R + + TV M+L F VCW P F L L NL+ + Sbjct: 214 THVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRF 273 Query: 286 LRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGP 334 + + L L + NS ++P+IY+FRS+E+ + +CC R+ P Sbjct: 274 MSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFP 322 >gi|71999131 opsin 3 [Homo sapiens] Length = 402 Score = 74.3 bits (181), Expect = 2e-13 Identities = 90/340 (26%), Positives = 130/340 (38%), Gaps = 45/340 (13%) Query: 18 AGGHSRLIVLHYNHSGRLAGRGGPEDGGL---------GALRGLSVAASCLVVL---ENL 65 +GGH Y G AG GP G G L++ + +L NL Sbjct: 7 SGGHG------YWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNL 60 Query: 66 LVLAAITSHMRSRRWVYYCLVNITLSDLLT---GAAYLANVLLSGARTFRLAPAQWFLRE 122 LVL R R + LVNI+LSDLL G + L + W Sbjct: 61 LVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFS 120 Query: 123 GLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLL 182 G LF ++ +T ++L A ER+ +V + S + I WL + PLL Sbjct: 121 GSLFGIVSIATLTVL--AYERYIRVVH----ARVINFSWAWRAITYIWLYSLAWAGAPLL 174 Query: 183 GWNCL--------CAFDRCSSLLPLYSKRYILF----CLVIFAGVLATIMG--LYGAIFR 228 GWN C D S ++LF CLV+ GV+A G LY Sbjct: 175 GWNRYILDVHGLGCTVDWKSK--DANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRML 232 Query: 229 LVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRG 288 Q + ++L K +++ FLVCW P + V G + Sbjct: 233 RCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISI 292 Query: 289 MDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLR 328 + ++ A + N+ NP+IY F R+ R++L LC LR Sbjct: 293 VSYLFAKS--NTVYNPVIYVFMIRKFRRSLLQLLCLRLLR 330 >gi|4506527 rhodopsin [Homo sapiens] Length = 348 Score = 72.8 bits (177), Expect = 5e-13 Identities = 62/282 (21%), Positives = 128/282 (45%), Gaps = 22/282 (7%) Query: 64 NLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREG 123 N L L H + R + Y L+N+ ++DL + L + + + EG Sbjct: 55 NFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEG 114 Query: 124 LLFTALAA-STFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLL 182 T + +SL+ A ER+ + +P++ + + G + W++A PL Sbjct: 115 FFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMG-VAFTWVMALACAAPPLA 173 Query: 183 GWN--------CLCAFDRCSSLLPLYSKRYILFCLVI-FAGVLATIMGLYGA-IFRLVQA 232 GW+ C C D + + ++ ++++ V+ F + I YG +F + +A Sbjct: 174 GWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEA 233 Query: 233 SGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVF---GSNLWAQEYLRGM 289 + Q+ ++ + + + V+++++AFL+CW P + + +F GSN + ++ Sbjct: 234 AAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP-YASVAFYIFTHQGSN-FGPIFMT-- 289 Query: 290 DWILALAVLNSAV-NPIIYSFRSREVCRAVLSFLCCGCLRLG 330 I A ++A+ NP+IY +++ +L+ +CCG LG Sbjct: 290 --IPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLG 329 >gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] Length = 359 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 54/309 (17%) Query: 59 LVVLENLLVLAAITSHMRSRRW-VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQ 117 + +L NLLV+ A+ + R+ Y +V++ +DLL +VL+ L Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDI 85 Query: 118 WF-------LREGLLFTALAASTFSLLFTAGERF-ATMVRPVAESGATKTSRVYGFIGLC 169 W +R L AS F L + +R+ A +P+ R+ +G C Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145 Query: 170 WLLAALLGMLPLL-GWNCLCAFD-----------RCSSLLPLYSKRYILFCLVI--FAGV 215 W++ + LP++ GWN + D + + + +K Y + C V+ + Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205 Query: 216 LATIMGLYGA------------IFRLVQASGQKAPRPAARRKARRL------LKTVLMIL 257 L ++ Y + + AS + P+ A + R+ KT+ +I+ Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIM 265 Query: 258 LAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW--ILALAVLNSAVNPIIYSFRSREVC 315 F +CW P F + D F + G W L L +NS +NP +Y+F ++ Sbjct: 266 GCFCLCWAPFFVTNIVDPF-----IDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFR 320 Query: 316 RAVLSFLCC 324 RA L LCC Sbjct: 321 RAFLIILCC 329 >gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] Length = 428 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 54/309 (17%) Query: 59 LVVLENLLVLAAITSHMRSRRW-VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQ 117 + +L NLLV+ A+ + R+ Y +V++ +DLL +VL+ L Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDI 85 Query: 118 WF-------LREGLLFTALAASTFSLLFTAGERF-ATMVRPVAESGATKTSRVYGFIGLC 169 W +R L AS F L + +R+ A +P+ R+ +G C Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145 Query: 170 WLLAALLGMLPLL-GWNCLCAFD-----------RCSSLLPLYSKRYILFCLVI--FAGV 215 W++ + LP++ GWN + D + + + +K Y + C V+ + Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205 Query: 216 LATIMGLYGA------------IFRLVQASGQKAPRPAARRKARRL------LKTVLMIL 257 L ++ Y + + AS + P+ A + R+ KT+ +I+ Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIM 265 Query: 258 LAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW--ILALAVLNSAVNPIIYSFRSREVC 315 F +CW P F + D F + G W L L +NS +NP +Y+F ++ Sbjct: 266 GCFCLCWAPFFVTNIVDPF-----IDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFR 320 Query: 316 RAVLSFLCC 324 RA L LCC Sbjct: 321 RAFLIILCC 329 >gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] Length = 360 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 54/309 (17%) Query: 59 LVVLENLLVLAAITSHMRSRRW-VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQ 117 + +L NLLV+ A+ + R+ Y +V++ +DLL +VL+ L Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDI 85 Query: 118 WF-------LREGLLFTALAASTFSLLFTAGERF-ATMVRPVAESGATKTSRVYGFIGLC 169 W +R L AS F L + +R+ A +P+ R+ +G C Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145 Query: 170 WLLAALLGMLPLL-GWNCLCAFD-----------RCSSLLPLYSKRYILFCLVI--FAGV 215 W++ + LP++ GWN + D + + + +K Y + C V+ + Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205 Query: 216 LATIMGLYGA------------IFRLVQASGQKAPRPAARRKARRL------LKTVLMIL 257 L ++ Y + + AS + P+ A + R+ KT+ +I+ Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIM 265 Query: 258 LAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW--ILALAVLNSAVNPIIYSFRSREVC 315 F +CW P F + D F + G W L L +NS +NP +Y+F ++ Sbjct: 266 GCFCLCWAPFFVTNIVDPF-----IDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFR 320 Query: 316 RAVLSFLCC 324 RA L LCC Sbjct: 321 RAFLIILCC 329 >gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] Length = 387 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 54/309 (17%) Query: 59 LVVLENLLVLAAITSHMRSRRW-VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQ 117 + +L NLLV+ A+ + R+ Y +V++ +DLL +VL+ L Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDI 85 Query: 118 WF-------LREGLLFTALAASTFSLLFTAGERF-ATMVRPVAESGATKTSRVYGFIGLC 169 W +R L AS F L + +R+ A +P+ R+ +G C Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145 Query: 170 WLLAALLGMLPLL-GWNCLCAFD-----------RCSSLLPLYSKRYILFCLVI--FAGV 215 W++ + LP++ GWN + D + + + +K Y + C V+ + Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205 Query: 216 LATIMGLYGA------------IFRLVQASGQKAPRPAARRKARRL------LKTVLMIL 257 L ++ Y + + AS + P+ A + R+ KT+ +I+ Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIM 265 Query: 258 LAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW--ILALAVLNSAVNPIIYSFRSREVC 315 F +CW P F + D F + G W L L +NS +NP +Y+F ++ Sbjct: 266 GCFCLCWAPFFVTNIVDPF-----IDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFR 320 Query: 316 RAVLSFLCC 324 RA L LCC Sbjct: 321 RAFLIILCC 329 >gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] Length = 378 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 54/309 (17%) Query: 59 LVVLENLLVLAAITSHMRSRRW-VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQ 117 + +L NLLV+ A+ + R+ Y +V++ +DLL +VL+ L Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDI 85 Query: 118 WF-------LREGLLFTALAASTFSLLFTAGERF-ATMVRPVAESGATKTSRVYGFIGLC 169 W +R L AS F L + +R+ A +P+ R+ +G C Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145 Query: 170 WLLAALLGMLPLL-GWNCLCAFD-----------RCSSLLPLYSKRYILFCLVI--FAGV 215 W++ + LP++ GWN + D + + + +K Y + C V+ + Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205 Query: 216 LATIMGLYGA------------IFRLVQASGQKAPRPAARRKARRL------LKTVLMIL 257 L ++ Y + + AS + P+ A + R+ KT+ +I+ Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIM 265 Query: 258 LAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW--ILALAVLNSAVNPIIYSFRSREVC 315 F +CW P F + D F + G W L L +NS +NP +Y+F ++ Sbjct: 266 GCFCLCWAPFFVTNIVDPF-----IDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFR 320 Query: 316 RAVLSFLCC 324 RA L LCC Sbjct: 321 RAFLIILCC 329 >gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] Length = 388 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 54/309 (17%) Query: 59 LVVLENLLVLAAITSHMRSRRW-VYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQ 117 + +L NLLV+ A+ + R+ Y +V++ +DLL +VL+ L Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDI 85 Query: 118 WF-------LREGLLFTALAASTFSLLFTAGERF-ATMVRPVAESGATKTSRVYGFIGLC 169 W +R L AS F L + +R+ A +P+ R+ +G C Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145 Query: 170 WLLAALLGMLPLL-GWNCLCAFD-----------RCSSLLPLYSKRYILFCLVI--FAGV 215 W++ + LP++ GWN + D + + + +K Y + C V+ + Sbjct: 146 WVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPF 205 Query: 216 LATIMGLYGA------------IFRLVQASGQKAPRPAARRKARRL------LKTVLMIL 257 L ++ Y + + AS + P+ A + R+ KT+ +I+ Sbjct: 206 LLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIM 265 Query: 258 LAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDW--ILALAVLNSAVNPIIYSFRSREVC 315 F +CW P F + D F + G W L L +NS +NP +Y+F ++ Sbjct: 266 GCFCLCWAPFFVTNIVDPF-----IDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFR 320 Query: 316 RAVLSFLCC 324 RA L LCC Sbjct: 321 RAFLIILCC 329 >gi|119508433 melanocortin 4 receptor [Homo sapiens] Length = 332 Score = 71.6 bits (174), Expect = 1e-12 Identities = 76/319 (23%), Positives = 136/319 (42%), Gaps = 43/319 (13%) Query: 27 LHYNHSGRLAGRGGPEDGG----LGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVY 82 LH N S L G DGG L + V + +LEN+LV+ AI + +Y Sbjct: 23 LHSNASESLGK--GYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMY 80 Query: 83 YCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWF------LREGLLFTALAASTFSL 136 + + ++ ++D+L + + ++ AQ F + + ++ ++L AS SL Sbjct: 81 FFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSL 140 Query: 137 LFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSL 196 L A +R+ T+ + RV I W + G+L ++ Sbjct: 141 LSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFII-------------- 186 Query: 197 LPLYS-KRYILFCLV-IFAGVLATIMGLYGAIF--------RLVQASGQKAPRPAARRKA 246 YS ++ CL+ +F +LA + LY +F R+ G A R A K Sbjct: 187 ---YSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKG 243 Query: 247 RRLLKTVLMILLAFLVCWGPLFGLLLADVF-GSNLWAQEYLRGMDWILALAVLNSAVNPI 305 T+ +++ F+VCW P F L+ + N + ++ + L L + NS ++P+ Sbjct: 244 AI---TLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL 300 Query: 306 IYSFRSREVCRAVLSFLCC 324 IY+ RS+E+ + +CC Sbjct: 301 IYALRSQELRKTFKEIICC 319 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.328 0.140 0.436 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,644,740 Number of Sequences: 37866 Number of extensions: 570877 Number of successful extensions: 3147 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 159 Number of HSP's successfully gapped in prelim test: 301 Number of HSP's that attempted gapping in prelim test: 2499 Number of HSP's gapped (non-prelim): 561 length of query: 384 length of database: 18,247,518 effective HSP length: 104 effective length of query: 280 effective length of database: 14,309,454 effective search space: 4006647120 effective search space used: 4006647120 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.