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Search of human proteins with 4502511
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502511 complement component 9 precursor [Homo sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502511 complement component 9 precursor [Homo sapiens] 1150 0.0
gi|4557389 complement component 8, alpha polypeptide precursor [... 261 2e-69
gi|189242612 complement component 6 precursor [Homo sapiens] 225 9e-59
gi|169636415 complement component 6 precursor [Homo sapiens] 225 9e-59
gi|4557391 complement component 8, beta polypeptide preproprotei... 222 6e-58
gi|45580688 complement component 7 precursor [Homo sapiens] 216 6e-56
gi|157384998 low density lipoprotein receptor-related protein 4 ... 60 5e-09
gi|93102379 low density lipoprotein-related protein 1B precursor... 57 6e-08
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 55 2e-07
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 54 4e-07
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 54 4e-07
gi|4507157 sortilin-related receptor containing LDLR class A rep... 52 1e-06
gi|29244926 corin [Homo sapiens] 52 1e-06
gi|148727288 low density lipoprotein receptor-related protein 6 ... 52 2e-06
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 52 2e-06
gi|119709832 low density lipoprotein receptor-related protein 5 ... 51 2e-06
gi|11415040 matriptase [Homo sapiens] 51 2e-06
gi|61744471 low density lipoprotein receptor-related protein 8 i... 50 7e-06
gi|61744467 low density lipoprotein receptor-related protein 8 i... 50 7e-06
gi|66082554 low density lipoprotein receptor-related protein 8 i... 50 7e-06
gi|65301119 low density lipoprotein receptor-related protein 8 i... 50 7e-06
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 49 2e-05
gi|208973262 low density lipoprotein-related protein 12 isoform ... 48 3e-05
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 48 3e-05
gi|28557796 low density lipoprotein receptor class A domain cont... 45 1e-04
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 45 2e-04
gi|32490559 low density lipoprotein receptor-related protein 10 ... 45 2e-04
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 44 4e-04
gi|133908621 perforin 1 precursor [Homo sapiens] 42 0.001
gi|40254808 perforin 1 precursor [Homo sapiens] 42 0.001
>gi|4502511 complement component 9 precursor [Homo sapiens]
Length = 559
Score = 1150 bits (2976), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQ 60
MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQ
Sbjct: 1 MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQ 60
Query: 61 MFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCN 120
MFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCN
Sbjct: 61 MFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCN 120
Query: 121 GDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGL 180
GDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGL
Sbjct: 121 GDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGL 180
Query: 181 CNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAIS 240
CNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAIS
Sbjct: 181 CNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAIS 240
Query: 241 LKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGE 300
LKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGE
Sbjct: 241 LKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGE 300
Query: 301 IHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIY 360
IHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIY
Sbjct: 301 IHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIY 360
Query: 361 VLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSEN 420
VLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSEN
Sbjct: 361 VLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSEN 420
Query: 421 LIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLV 480
LIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLV
Sbjct: 421 LIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLV 480
Query: 481 PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACE 540
PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACE
Sbjct: 481 PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACE 540
Query: 541 ISKQKISEGLPALEFPNEK 559
ISKQKISEGLPALEFPNEK
Sbjct: 541 ISKQKISEGLPALEFPNEK 559
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 261 bits (666), Expect = 2e-69
Identities = 168/568 (29%), Positives = 269/568 (47%), Gaps = 53/568 (9%)
Query: 7 FAVAICILEISILTAQYTTSYDPELTES---SGSASHIDCRMSPWSEWSQCDPCLRQMFR 63
FAV IL S++T Q + ++ + + + + + C++S WSEW+ C PC + +R
Sbjct: 2 FAVVFFIL--SLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYR 59
Query: 64 SRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCS-TGRCIKMRLRCNGD 122
RS+ +F G C+ + D+ C + C + CG DFQC TGRC+K L CNGD
Sbjct: 60 HRSLLQPNKFGGTICSGDIWDQASCSSSTTCV-RQAQCGQDFQCKETGRCLKRHLVCNGD 118
Query: 123 NDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNG--- 179
DC D SDEDDCE E ++ A G NIL + + +D +Y G
Sbjct: 119 QDCLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCE 178
Query: 180 --------------LCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFK 225
C R G+ Y+R+P+N +E + +E Y+ +
Sbjct: 179 TVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLS 238
Query: 226 SIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLS 285
+ ++K+ +F I + A S L G G S+S++ ++ L+
Sbjct: 239 KVKKDKSDSFGVTIGIG---------------PAGSPLLVGVG---VSHSQDTSFLNELN 280
Query: 286 YSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTH 345
++K+ +F + ++ F MR D++L + + LP Y G Y F+ YGTH
Sbjct: 281 KYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTH 340
Query: 346 YSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDC 405
Y +SGS+GG+YE I V+DKA M+ G+ +DI C G L + +I+VG + D C
Sbjct: 341 YITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYE-DKINVGGGLSGDHC 399
Query: 406 VKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDA 465
K G G+ ++D++S +RGG+ ++ L + R T+ + +W S+
Sbjct: 400 KKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQN--RSTI----TYRSWGRSLKYN 453
Query: 466 PVLISQKLSPIYNLV-PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDG 524
PV+I ++ PI+ ++ + K+QNL RA++ Y+ EF+ +C C N G IL
Sbjct: 454 PVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGT 513
Query: 525 KCLCACPFKFEGIACEISKQKISEGLPA 552
C C C G ACE Q +EG A
Sbjct: 514 SCRCQCRLGSLGAACE---QTQTEGAKA 538
>gi|189242612 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 225 bits (573), Expect = 9e-59
Identities = 141/514 (27%), Positives = 238/514 (46%), Gaps = 32/514 (6%)
Query: 30 ELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCV 89
E E + I+C + + WS CDPC+ + + RS+ QF G+ CT + + C+
Sbjct: 69 ETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCI 128
Query: 90 PTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEE 149
P++ C+ E DC N F+C +GRCI +L CNG+NDCGD SDE DC + C R
Sbjct: 129 PSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDC-GRTKAVC-TRKYNP 186
Query: 150 SELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETK-G 208
+ G G + L +P DN F G+C + T YR P N+ ++ +E +
Sbjct: 187 IPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTA 246
Query: 209 EKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKG 268
E + +T+ Y++ + Q+ + + S ++K +
Sbjct: 247 EDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSE--------------- 291
Query: 269 SFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPT 328
+ + N ++ + S KK+ F+ + + + F + +D+ L+ F+ + LP
Sbjct: 292 ----NINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPL 347
Query: 329 TYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVS 388
Y Y + +GTHY +SGSLGG+Y+L+Y +K G+ ++ K C+
Sbjct: 348 EYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKR 407
Query: 389 LAFS-EISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELK-EKLLR 446
+ F+ + V + ++ EG + ++ +SLIRGG +Y L EK
Sbjct: 408 VLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKS-----ISLIRGGRSEYGAALAWEKGSS 462
Query: 447 GTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFS 506
G ++ F W S+ + P +I +L+PI +LV + A K+ NL +A+++Y +F
Sbjct: 463 G--LEEKTFSEWLESVKENPAVIDFELAPIVDLVR-NIPCAVTKRNNLRKALQEYAAKFD 519
Query: 507 VRKCHTCQNGGTVILMDGKCLCACPFKFEGIACE 540
+C C N G L +CLC C G CE
Sbjct: 520 PCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCE 553
Score = 30.8 bits (68), Expect = 3.4
Identities = 30/115 (26%), Positives = 42/115 (36%), Gaps = 23/115 (20%)
Query: 41 IDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD 100
+D + WS WS CD ++ Q GKRC G++RQ E+D
Sbjct: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCE---GEKRQ----------EED 610
Query: 101 CGNDFQCSTGR-CIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELAR 154
C + G+ CI ND + + D E E C V E+ R
Sbjct: 611 CTFSIMENNGQPCI---------NDDEEMKEVDLPEIEADSGCPQPVPPENGFIR 656
>gi|169636415 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 225 bits (573), Expect = 9e-59
Identities = 141/514 (27%), Positives = 238/514 (46%), Gaps = 32/514 (6%)
Query: 30 ELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCV 89
E E + I+C + + WS CDPC+ + + RS+ QF G+ CT + + C+
Sbjct: 69 ETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCI 128
Query: 90 PTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEE 149
P++ C+ E DC N F+C +GRCI +L CNG+NDCGD SDE DC + C R
Sbjct: 129 PSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDC-GRTKAVC-TRKYNP 186
Query: 150 SELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETK-G 208
+ G G + L +P DN F G+C + T YR P N+ ++ +E +
Sbjct: 187 IPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTA 246
Query: 209 EKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKG 268
E + +T+ Y++ + Q+ + + S ++K +
Sbjct: 247 EDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSE--------------- 291
Query: 269 SFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPT 328
+ + N ++ + S KK+ F+ + + + F + +D+ L+ F+ + LP
Sbjct: 292 ----NINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPL 347
Query: 329 TYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVS 388
Y Y + +GTHY +SGSLGG+Y+L+Y +K G+ ++ K C+
Sbjct: 348 EYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKR 407
Query: 389 LAFS-EISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELK-EKLLR 446
+ F+ + V + ++ EG + ++ +SLIRGG +Y L EK
Sbjct: 408 VLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKS-----ISLIRGGRSEYGAALAWEKGSS 462
Query: 447 GTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFS 506
G ++ F W S+ + P +I +L+PI +LV + A K+ NL +A+++Y +F
Sbjct: 463 G--LEEKTFSEWLESVKENPAVIDFELAPIVDLVR-NIPCAVTKRNNLRKALQEYAAKFD 519
Query: 507 VRKCHTCQNGGTVILMDGKCLCACPFKFEGIACE 540
+C C N G L +CLC C G CE
Sbjct: 520 PCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCE 553
Score = 30.8 bits (68), Expect = 3.4
Identities = 30/115 (26%), Positives = 42/115 (36%), Gaps = 23/115 (20%)
Query: 41 IDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD 100
+D + WS WS CD ++ Q GKRC G++RQ E+D
Sbjct: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCE---GEKRQ----------EED 610
Query: 101 CGNDFQCSTGR-CIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELAR 154
C + G+ CI ND + + D E E C V E+ R
Sbjct: 611 CTFSIMENNGQPCI---------NDDEEMKEVDLPEIEADSGCPQPVPPENGFIR 656
>gi|4557391 complement component 8, beta polypeptide preproprotein
[Homo sapiens]
Length = 591
Score = 222 bits (566), Expect = 6e-58
Identities = 144/512 (28%), Positives = 239/512 (46%), Gaps = 41/512 (8%)
Query: 41 IDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD 100
IDC +S WS W+ CDPC ++ +R + QF+G+ C + + CV PC ++
Sbjct: 63 IDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPC-GSQVR 121
Query: 101 CGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGI 160
C TGRC+ RL CNGDNDCGD SDE +C + C+ + + + A GI
Sbjct: 122 CEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKK-CQHEMDQYWGIGSLAS-GI 179
Query: 161 NILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQ 220
N+ D+ +Y G C+ NT +R+P+NV S +T+G+ F + YE
Sbjct: 180 NLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTPQTQGKYEFILKEYESY 237
Query: 221 IEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFR----FSYSK 276
+ +++ ++ S + K E SS S GK R FS++K
Sbjct: 238 SDFERNVTEKMASKSGFSFGFKIPGI--------FELGISSQSDRGKHYIRRTKRFSHTK 289
Query: 277 NETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYF 336
+ +FLH + ++ + + ++ R ++L F+ +K LP Y GEY
Sbjct: 290 S---------------VFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYR 334
Query: 337 AFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISV 396
+GTHY + LGG+YE V++K +M+R L ++ C + A E+ V
Sbjct: 335 DLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYV 394
Query: 397 GAEFNKDDCVKRGEGRAVNITS--ENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTD 454
+ C RG + + + +++D+V L+RGG ++ L + L +
Sbjct: 395 SLGVSVGKC--RGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADL---- 448
Query: 455 FVNWASSINDAPVLISQKLSPIYNLV-PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTC 513
W ++ P +I K+ P+Y LV + +QN+++A+E++ E S C C
Sbjct: 449 MQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPC 508
Query: 514 QNGGTVILMDGKCLCACPFKFEGIACEISKQK 545
Q G +L +C C CP +G+ACE+S +K
Sbjct: 509 QGNGVPVLKGSRCDCICPVGSQGLACEVSYRK 540
>gi|45580688 complement component 7 precursor [Homo sapiens]
Length = 843
Score = 216 bits (549), Expect = 6e-56
Identities = 152/519 (29%), Positives = 235/519 (45%), Gaps = 54/519 (10%)
Query: 30 ELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCV 89
E S ++S ++C+ ++ WS+C+ C + R RS+ V+GQ+ G+ C + + C
Sbjct: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCE 74
Query: 90 PTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCG-DFSDEDDCE-SEPRPPCR-DRV 146
PT C E+ CG F+C +G+CI L CNGD+DC D +DED CE SE RP C D+
Sbjct: 75 PTRGC-PTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKP 133
Query: 147 VEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYET 206
EL G G N L + + + + G C + G+ +YR NV S ++
Sbjct: 134 PPNIEL---TGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQV 190
Query: 207 KGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHG 266
K +F E Y K E TS S
Sbjct: 191 KINNDFNYEFYNSTWSYVKHTSTEHTS-----------------------------SSRK 221
Query: 267 KGSFRFSYSKNETYQLFLSYSSK-KEKMFLHVKGEIHLGRFVMRNRDVV-LTTTFVDDIK 324
+ FR S S + +Y + K K L V+ + + +F+ N + + L F ++
Sbjct: 222 RSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELS 281
Query: 325 ALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRC--LG 382
LP+ Y+ Y ++ YGTHY SGSLGG Y +++ +D +K+ + K+C G
Sbjct: 282 HLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSG 341
Query: 383 YHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKE 442
+H V +F+ C + ++N + IRGG + L
Sbjct: 342 WHFVV-----------KFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSY 390
Query: 443 KLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYI 502
L + + WA S+ + P +I QKL+P+Y LV ++ A +KK L+ A+E+Y+
Sbjct: 391 LELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVK-EVPCASVKKLYLKWALEEYL 449
Query: 503 NEFSVRKCHTCQNGGTVILMDGKCLCAC-PFKFEGIACE 540
+EF C CQNGG + CLC C P+ F G ACE
Sbjct: 450 DEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTF-GAACE 487
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 60.1 bits (144), Expect = 5e-09
Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 15/107 (14%)
Query: 42 DCRMSPWSEWSQCD---PCLRQMFRSRS---IEVFGQFNGKRCTDAVGDRRQCVPTEPCE 95
DC WS+ S C PC F S I + +G D D R C T C
Sbjct: 215 DC--GDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCT-TSMCT 271
Query: 96 DAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPC 142
F+C +GRC+++ RC+G++DC D SDE++CE+ P C
Sbjct: 272 ------AEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQC 312
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/85 (42%), Positives = 43/85 (50%), Gaps = 13/85 (15%)
Query: 78 CTDAVGDRRQC---VPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C D D C VP PC E FQC+ GRCI C+GD+DCGD+SDE DC
Sbjct: 173 CKDG-SDEENCPSAVPAPPCNLEE------FQCAYGRCILDIYHCDGDDDCGDWSDESDC 225
Query: 135 ESEPRPPCRD-RVVEESELARTAGY 158
S PCR + +S L AG+
Sbjct: 226 SS--HQPCRSGEFMCDSGLCINAGW 248
Score = 57.0 bits (136), Expect = 4e-08
Identities = 34/91 (37%), Positives = 42/91 (46%), Gaps = 23/91 (25%)
Query: 88 CVPTEPCEDAEDDCGN---------------DFQCSTGRCIKMRLRCNGDNDCGDFSDED 132
C+P + D ++DCG+ DF C G+CI+ C+GDNDC D SDE
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQ 103
Query: 133 DCESEPRPPCRDRVVEESELARTAGYGINIL 163
DC PP R EE E GY I L
Sbjct: 104 DC-----PP---RECEEDEFPCQNGYCIRSL 126
Score = 53.1 bits (126), Expect = 6e-07
Identities = 31/91 (34%), Positives = 41/91 (45%), Gaps = 32/91 (35%)
Query: 84 DRRQCVPTE------PCE-----------DAEDDCGN--------------DFQCSTGRC 112
D + C P E PC+ D ++DCG+ +F+CS G C
Sbjct: 101 DEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSC 160
Query: 113 IKMRLRCNGDNDCGDFSDEDDCESE-PRPPC 142
I C+GD DC D SDE++C S P PPC
Sbjct: 161 IAEHWYCDGDTDCKDGSDEENCPSAVPAPPC 191
Score = 52.4 bits (124), Expect = 1e-06
Identities = 44/147 (29%), Positives = 59/147 (40%), Gaps = 37/147 (25%)
Query: 32 TESSGSASHIDCRMSPWSEWSQCDP--CLRQMFR-SRSIEVFGQFNGKRCTDAVGDRRQ- 87
++ S +SH CR + CD C+ +R + Q + + CT ++ Q
Sbjct: 220 SDESDCSSHQPCRSGEF----MCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQF 275
Query: 88 ------CVPTEPCEDAEDDCGND------------------FQCSTGRCIKMRLRCNGDN 123
CV D EDDC ++ F C GRCI R CNG N
Sbjct: 276 RCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVN 335
Query: 124 DCGDFSDEDDCESEPRPPCRDRVVEES 150
DCGD SDE P+ CR R EE+
Sbjct: 336 DCGDNSDE-----SPQQNCRPRTGEEN 357
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 56.6 bits (135), Expect = 6e-08
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 7/57 (12%)
Query: 82 VGDRRQCVPTEPCEDAEDDCG-------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
+ + C + C D D+ G N F+CS+GRCI C+GDNDCGDFSDE
Sbjct: 981 ISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDE 1037
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/79 (40%), Positives = 39/79 (49%), Gaps = 16/79 (20%)
Query: 80 DAVGDRRQCVPTEPCEDAEDDCG-----------NDFQC-STGRCIKMRLRCNGDNDCGD 127
+ V D +C + CED D+ G F C STGRCI C+GD DC D
Sbjct: 1065 NCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 1124
Query: 128 FSDEDDCES----EPRPPC 142
SDEDDC+S P+ PC
Sbjct: 1125 QSDEDDCDSFLCGPPKHPC 1143
Score = 49.7 bits (117), Expect = 7e-06
Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 17/65 (26%)
Query: 87 QCVPTEPCEDAEDDCGND-----------------FQCSTGRCIKMRLRCNGDNDCGDFS 129
+C+P D EDDCG+ F C +GRCI + C+ D+DCGD S
Sbjct: 938 RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGS 997
Query: 130 DEDDC 134
DE C
Sbjct: 998 DEVGC 1002
Score = 48.9 bits (115), Expect = 1e-05
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 15/66 (22%)
Query: 86 RQCVPTEPCEDAEDDCGN---------------DFQCSTGRCIKMRLRCNGDNDCGDFSD 130
R+C+P D E+DCG+ +F+C+ G CI RCN + DC D SD
Sbjct: 2562 RRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASD 2621
Query: 131 EDDCES 136
E +C +
Sbjct: 2622 EKNCNN 2627
Score = 47.4 bits (111), Expect = 4e-05
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 8/58 (13%)
Query: 88 CVPTEPCEDAEDD-------CG-NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESE 137
C C DA D+ CG ++FQC CI RC+ NDC D SDE++C+ +
Sbjct: 3456 CDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQ 3513
Score = 47.0 bits (110), Expect = 5e-05
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 15/64 (23%)
Query: 88 CVPTEPCEDAEDDCGN---------------DFQCSTGRCIKMRLRCNGDNDCGDFSDED 132
C+P D+++DC + DF C+ G C+ R C+GD DC D SDE
Sbjct: 3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDER 3547
Query: 133 DCES 136
+CE+
Sbjct: 3548 NCET 3551
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/45 (44%), Positives = 28/45 (62%), Gaps = 1/45 (2%)
Query: 94 CEDAEDDCGN-DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESE 137
CE A C + ++ C++ CI L+CNG+ DC D SDE DC +E
Sbjct: 3587 CEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTE 3631
Score = 46.6 bits (109), Expect = 6e-05
Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 16/66 (24%)
Query: 87 QCVPTEPCEDAEDDCGND----------------FQCSTGRCIKMRLRCNGDNDCGDFSD 130
+C+P D DDCG+ FQC TG C C+G+NDCGD SD
Sbjct: 3328 KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSD 3387
Query: 131 EDDCES 136
E +C++
Sbjct: 3388 ELNCDT 3393
Score = 46.2 bits (108), Expect = 8e-05
Identities = 23/62 (37%), Positives = 31/62 (50%), Gaps = 16/62 (25%)
Query: 96 DAEDDCGND---------------FQCSTG-RCIKMRLRCNGDNDCGDFSDEDDCESEPR 139
D E+DCG++ F+C+ +CI + LRCNG +DCGD DE DC
Sbjct: 3377 DGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
Query: 140 PP 141
P
Sbjct: 3437 SP 3438
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/73 (35%), Positives = 32/73 (43%), Gaps = 8/73 (10%)
Query: 80 DAVGDRRQCVPTEPCEDAEDD------CGND-FQCSTGRCIKMRLRCNGDNDCGDFSDED 132
D V R C C D D+ C D F+CS G+CI + +C+G DC DE
Sbjct: 3526 DCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEK 3585
Query: 133 DCESEPRPPCRDR 145
CE P C R
Sbjct: 3586 SCE-PASPTCSSR 3597
Score = 45.4 bits (106), Expect = 1e-04
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 15/76 (19%)
Query: 86 RQCVPTEPCEDA--EDDCG------------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
+ C + C D ED CG ++F CS +CI M L+C+ +DCGD SDE
Sbjct: 3734 QMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDE 3793
Query: 132 DDCESEPRP-PCRDRV 146
C P C D V
Sbjct: 3794 QGCRIAPTEYTCEDNV 3809
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/53 (41%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 84 DRRQCVPTEP-CEDAEDDCGNDF-QCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
D P P C+ AE C + F C GRCI C+ +DCGD SDE +C
Sbjct: 2873 DHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 43.1 bits (100), Expect = 7e-04
Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 7/53 (13%)
Query: 88 CVPTEPCEDAEDD------CG-NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDD 133
C + CED D+ C N F CS +CI C+G++DCGD DE D
Sbjct: 2701 CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 23/87 (26%)
Query: 71 GQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGND---------------FQCSTGR-CIK 114
GQF +CT ++C+P + +DDCG++ FQC T + CI
Sbjct: 3399 GQF---KCTK----NQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCIS 3451
Query: 115 MRLRCNGDNDCGDFSDEDDCESEPRPP 141
C+ D DC D SDE +C+ + P
Sbjct: 3452 KLWVCDEDPDCADASDEANCDKKTCGP 3478
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 10/79 (12%)
Query: 94 CEDAEDD---------CGNDFQ-CSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCR 143
C+D D+ C F+ C RCI C+G+NDCGD SDE DC+
Sbjct: 2536 CKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVE 2595
Query: 144 DRVVEESELARTAGYGINI 162
R + + + R+A NI
Sbjct: 2596 FRCADGTCIPRSARCNQNI 2614
Score = 41.6 bits (96), Expect = 0.002
Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 17/61 (27%)
Query: 88 CVPTEPCEDAEDDCGN----------------DFQCSTGRCI-KMRLRCNGDNDCGDFSD 130
C+P + D +DDCG+ +F C+ GRC+ + +C+GD DC D SD
Sbjct: 2817 CIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSD 2876
Query: 131 E 131
E
Sbjct: 2877 E 2877
Score = 40.4 bits (93), Expect = 0.004
Identities = 24/73 (32%), Positives = 33/73 (45%), Gaps = 11/73 (15%)
Query: 71 GQFNGKRCTDAVGDRRQCVPTEPCEDAEDD---------CGND-FQCSTGRCIKMRLRCN 120
G+F K + R +C + C D D+ C +D F+C RCI R C+
Sbjct: 848 GEFRCKN-RHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCD 906
Query: 121 GDNDCGDFSDEDD 133
G NDCG DE +
Sbjct: 907 GANDCGSNEDESN 919
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/39 (46%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 102 GNDFQCST-GRCIKMRLRCNGDNDCGDFSDEDDCESEPR 139
GN+FQC G C+ RC+G+ DC D SDE C R
Sbjct: 1055 GNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIR 1093
Score = 40.0 bits (92), Expect = 0.006
Identities = 27/88 (30%), Positives = 36/88 (40%), Gaps = 20/88 (22%)
Query: 77 RCTDAVGDRR--QCVPTEPCEDAEDD--CGND---------------FQC-STGRCIKMR 116
RC D R +C C DA D+ C N +C ST C+
Sbjct: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPT 2656
Query: 117 LRCNGDNDCGDFSDEDDCESEPRPPCRD 144
C+G NDCGD+SDE C + + C +
Sbjct: 2657 WICDGSNDCGDYSDELKCPVQNKHKCEE 2684
Score = 39.7 bits (91), Expect = 0.007
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 26/108 (24%)
Query: 40 HIDCRMSPWSEWSQCDP-----------CLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQC 88
H DC+ + C+P C S S++ G+++ C D D C
Sbjct: 3575 HEDCKYG--EDEKSCEPASPTCSSREYICASDGCISASLKCNGEYD---CADG-SDEMDC 3628
Query: 89 VPTEPCEDAEDDCGNDFQCST-GRCIKMRLRCNGDNDCGDFSDEDDCE 135
V TE ED F+C CI +R C+G +DC D SDE++CE
Sbjct: 3629 V-TECKED-------QFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCE 3668
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/58 (36%), Positives = 28/58 (48%), Gaps = 19/58 (32%)
Query: 96 DAEDDCGND----------FQCSTGR---------CIKMRLRCNGDNDCGDFSDEDDC 134
D EDDCG++ F C + R C++ CNG ++CGD SDED C
Sbjct: 3694 DGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
Score = 39.3 bits (90), Expect = 0.010
Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 17/62 (27%)
Query: 87 QCVPTEPCEDAEDDCGND-----------------FQCSTGRCIKMRLRCNGDNDCGDFS 129
+C+P D +DCG++ F C GRCI C+ ++DCGD +
Sbjct: 897 RCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQT 956
Query: 130 DE 131
DE
Sbjct: 957 DE 958
Score = 38.5 bits (88), Expect = 0.016
Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 19/66 (28%)
Query: 89 VPTEPCEDAEDDCG------------------NDFQCSTGRCIKMRLRCNGDNDCGDFSD 130
+PT C D +DCG N F C +GRCI C+G DC D D
Sbjct: 2654 LPTWIC-DGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRD 2712
Query: 131 EDDCES 136
E C+S
Sbjct: 2713 EFHCDS 2718
Score = 38.1 bits (87), Expect = 0.021
Identities = 17/44 (38%), Positives = 22/44 (50%), Gaps = 6/44 (13%)
Query: 88 CVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
C P C++ N F C CI + C+ D+DCGD SDE
Sbjct: 2799 CAPNNTCDE------NAFMCHNKVCIPKQFVCDHDDDCGDGSDE 2836
Score = 37.7 bits (86), Expect = 0.028
Identities = 16/33 (48%), Positives = 22/33 (66%), Gaps = 1/33 (3%)
Query: 103 NDFQCSTGRCIKMRLRCNGDNDCGDFSDE-DDC 134
+ F+C T +CI +C+ +DCGD SDE DDC
Sbjct: 3320 SQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDC 3352
Score = 35.8 bits (81), Expect = 0.11
Identities = 32/108 (29%), Positives = 44/108 (40%), Gaps = 14/108 (12%)
Query: 92 EPCEDAEDDC-GNDFQCSTGRCIKMRLRCNGDNDCGDFSDE--DDCESEPRPPCRDRVVE 148
E CE + C ++F C+ C C+G++DCGD SDE D C P R
Sbjct: 3665 ENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCR 3724
Query: 149 ESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRP 196
+ + + N G+D DN + D G LTY RP
Sbjct: 3725 NNRICLQSEQMCN--GIDECG---DNS------DEDHCGGKLTYKARP 3761
Score = 35.4 bits (80), Expect = 0.14
Identities = 25/80 (31%), Positives = 33/80 (41%), Gaps = 9/80 (11%)
Query: 74 NGKRCTDAVGDRRQCVPTEPCEDAEDDCG--NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
NG+ GDR + C C ++F+C G CI +L C+G C D SDE
Sbjct: 2484 NGRVNCSCRGDRI-LLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDE 2542
Query: 132 DDCESEPR------PPCRDR 145
E R PC +R
Sbjct: 2543 KLLYCENRSCRRGFKPCYNR 2562
Score = 33.5 bits (75), Expect = 0.53
Identities = 22/56 (39%), Positives = 26/56 (46%), Gaps = 16/56 (28%)
Query: 94 CEDA--EDDCGNDFQCS---------TGRCIKMRLRCNGDNDCGDFSDE----DDC 134
CED EDDC + F C T C++ CNG DC D SDE D+C
Sbjct: 1122 CEDQSDEDDC-DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDEC 1176
Score = 33.1 bits (74), Expect = 0.69
Identities = 19/64 (29%), Positives = 26/64 (40%), Gaps = 18/64 (28%)
Query: 86 RQCVPTEPCEDAEDDCGND-----------------FQCSTGR-CIKMRLRCNGDNDCGD 127
++C+ D EDDCG+ F C R C+ C+G+ DC D
Sbjct: 2730 QKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPD 2789
Query: 128 FSDE 131
SDE
Sbjct: 2790 GSDE 2793
Score = 30.8 bits (68), Expect = 3.4
Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 1/34 (2%)
Query: 511 HTCQNGGTVILMD-GKCLCACPFKFEGIACEISK 543
H C N + + D G C CP ++EG CE+ K
Sbjct: 4327 HYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDK 4360
Score = 30.0 bits (66), Expect = 5.8
Identities = 14/33 (42%), Positives = 16/33 (48%), Gaps = 2/33 (6%)
Query: 112 CIKMRLRCNGDNDCGDFSDE--DDCESEPRPPC 142
C+ C+GD DC D SDE D C E C
Sbjct: 45 CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKC 77
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 54.7 bits (130), Expect = 2e-07
Identities = 26/72 (36%), Positives = 34/72 (47%), Gaps = 17/72 (23%)
Query: 84 DRRQCVPTEPCEDAEDDCGN-----------------DFQCSTGRCIKMRLRCNGDNDCG 126
D +C+P D EDDCG+ F+C RC+ R +C+ DNDCG
Sbjct: 3503 DSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCG 3562
Query: 127 DFSDEDDCESEP 138
D SDE+ C P
Sbjct: 3563 DNSDEESCTPRP 3574
Score = 53.9 bits (128), Expect = 4e-07
Identities = 24/51 (47%), Positives = 30/51 (58%), Gaps = 7/51 (13%)
Query: 84 DRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
D C P PC ++E F C+ GRCI R +C+GD+DC D SDE DC
Sbjct: 3566 DEESCTP-RPCSESE------FSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 53.5 bits (127), Expect = 5e-07
Identities = 25/65 (38%), Positives = 32/65 (49%), Gaps = 17/65 (26%)
Query: 87 QCVPTEPCEDAEDDCGN-----------------DFQCSTGRCIKMRLRCNGDNDCGDFS 129
+C+P D +DDCG+ F C+ GRCI + RC+ DNDCGD S
Sbjct: 947 RCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNS 1006
Query: 130 DEDDC 134
DE C
Sbjct: 1007 DEAGC 1011
Score = 53.1 bits (126), Expect = 6e-07
Identities = 27/68 (39%), Positives = 35/68 (51%), Gaps = 14/68 (20%)
Query: 86 RQCVPTEPCEDA--EDDCG------------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
RQC T+ C D E+DC +F C RC+ LRCN +DCGD SDE
Sbjct: 3714 RQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE 3773
Query: 132 DDCESEPR 139
+DC +P+
Sbjct: 3774 EDCSIDPK 3781
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/78 (37%), Positives = 40/78 (51%), Gaps = 13/78 (16%)
Query: 74 NGKRCTDAVGDRRQCVPTEPCEDAEDDCG-------NDFQCSTGRCIKMRLRCNGDNDCG 126
N RC + +C C D D+ G F+C++GRCI C+GDNDCG
Sbjct: 985 NNGRC---ININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCG 1041
Query: 127 DFSDED--DCESE-PRPP 141
D+SDE +C ++ RPP
Sbjct: 1042 DYSDETHANCTNQATRPP 1059
Score = 50.4 bits (119), Expect = 4e-06
Identities = 30/86 (34%), Positives = 37/86 (43%), Gaps = 20/86 (23%)
Query: 77 RCTDA--VGDRRQCVPTEPCEDAED-------DCGNDFQCS-----------TGRCIKMR 116
RC D +G+ +C CEDA D DC + F+ T C
Sbjct: 2611 RCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPS 2670
Query: 117 LRCNGDNDCGDFSDEDDCESEPRPPC 142
C+G NDCGD+SDE DC RP C
Sbjct: 2671 WVCDGANDCGDYSDERDCPGVKRPRC 2696
Score = 50.4 bits (119), Expect = 4e-06
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 16/65 (24%)
Query: 87 QCVPTEPCEDAEDDCGN----------------DFQCSTGRCIKMRLRCNGDNDCGDFSD 130
+C+P D EDDCG+ FQCSTG C C+GDNDC D SD
Sbjct: 3345 KCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSD 3404
Query: 131 EDDCE 135
E +C+
Sbjct: 3405 EANCD 3409
Score = 49.7 bits (117), Expect = 7e-06
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 3/54 (5%)
Query: 84 DRRQCVPTEP-CEDAEDDCG--NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
D+ P P C E C + F CS+GRC+ L CNG +DCGD SDE C
Sbjct: 2886 DQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC 2939
Score = 49.3 bits (116), Expect = 9e-06
Identities = 34/93 (36%), Positives = 42/93 (45%), Gaps = 17/93 (18%)
Query: 49 SEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD------CG 102
S+ C P R S F NG RC + R +C C D D+ C
Sbjct: 3565 SDEESCTP------RPCSESEFSCANG-RC---IAGRWKCDGDHDCADGSDEKDCTPRCD 3614
Query: 103 ND-FQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
D FQC +G CI +R RC+ D DC D SDE+ C
Sbjct: 3615 MDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/80 (41%), Positives = 42/80 (52%), Gaps = 13/80 (16%)
Query: 76 KRCTDAVG--DR-RQCVP--TEPCEDAEDDCGND-FQCS-TGRCIKMRLRCNGDNDCGDF 128
KRC V DR CV EP + CG D F+C +GRCI R +C+G++DCGD
Sbjct: 3464 KRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDG 3523
Query: 129 SDEDDCESEPRPPCRDRVVE 148
SD EP+ C +R E
Sbjct: 3524 SD------EPKEECDERTCE 3537
Score = 47.0 bits (110), Expect = 5e-05
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 17/65 (26%)
Query: 84 DRRQCVPTEPCEDAEDDCGND-----------------FQCSTGRCIKMRLRCNGDNDCG 126
+ +C+P D ++DCGN F C++GRCI + C+ D+DCG
Sbjct: 903 ENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCG 962
Query: 127 DFSDE 131
D SDE
Sbjct: 963 DRSDE 967
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 12/72 (16%)
Query: 82 VGDRRQCVPTEPCEDAEDD---------CGND-FQCSTGRCIKMRLRCNGDNDCGDFSDE 131
+ +R +C C D D+ C +D F+C RCI R C+GDNDCG+ DE
Sbjct: 867 IQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDE 926
Query: 132 DD--CESEPRPP 141
+ C + PP
Sbjct: 927 SNATCSARTCPP 938
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 24/73 (32%)
Query: 87 QCVPTEPCEDAEDDCGN-----------------------DFQCST-GRCIKMRLRCNGD 122
+C+P D ++DCG+ +FQC G CI +R RC+GD
Sbjct: 1026 RCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGD 1085
Query: 123 NDCGDFSDEDDCE 135
DC D SDE CE
Sbjct: 1086 TDCMDSSDEKSCE 1098
Score = 45.8 bits (107), Expect = 1e-04
Identities = 24/57 (42%), Positives = 28/57 (49%), Gaps = 10/57 (17%)
Query: 88 CVPTEPCEDAEDD---------CGNDF-QCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C C+D D+ C F QCS GRC+ L CNG +DCGD SDE C
Sbjct: 2544 CDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC 2600
Score = 44.3 bits (103), Expect = 3e-04
Identities = 26/70 (37%), Positives = 33/70 (47%), Gaps = 15/70 (21%)
Query: 87 QCVPTEPCEDAEDDC--GND------------FQCSTGRCIKMRLRCNGDNDCGDFSDE- 131
+C+P D EDDC G D F+C RCI + C+G +DCGD SDE
Sbjct: 2707 RCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2766
Query: 132 DDCESEPRPP 141
CE + P
Sbjct: 2767 AHCEGKTCGP 2776
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/63 (38%), Positives = 33/63 (52%), Gaps = 17/63 (26%)
Query: 86 RQCVPTE-------PCEDAEDD--------CG-NDFQCSTGRCIKMRL-RCNGDNDCGDF 128
RQC+P C D D+ CG ++F+C+ GRC+ R C+G+NDC D
Sbjct: 2828 RQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQ 2887
Query: 129 SDE 131
SDE
Sbjct: 2888 SDE 2890
Score = 43.1 bits (100), Expect = 7e-04
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 6/43 (13%)
Query: 89 VPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
VP C+ E F C+ RCI+ R +C+GDNDC D SDE
Sbjct: 849 VPPPQCQPGE------FACANSRCIQERWKCDGDNDCLDNSDE 885
Score = 43.1 bits (100), Expect = 7e-04
Identities = 22/56 (39%), Positives = 28/56 (50%), Gaps = 9/56 (16%)
Query: 88 CVPTEPCEDAEDDCGND--------FQCS-TGRCIKMRLRCNGDNDCGDFSDEDDC 134
C C+D D+ D F+C+ T RCI RCNG ++CGD DE DC
Sbjct: 3393 CDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 3448
Score = 42.7 bits (99), Expect = 9e-04
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 12/71 (16%)
Query: 85 RRQCVPTEPCEDAEDD--CG--------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE--D 132
R +C C D D+ CG ++FQC+ C + +C+G++DCGD SDE +
Sbjct: 3629 RWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPE 3688
Query: 133 DCESEPRPPCR 143
+C PP R
Sbjct: 3689 ECARFVCPPNR 3699
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/56 (42%), Positives = 28/56 (50%), Gaps = 7/56 (12%)
Query: 94 CEDAEDDCGND--FQCS-TGRCIKMRLRCNGDNDCGDFSDEDDCES----EPRPPC 142
CE C F C + RCI C+GDNDC D SDE++CES P PC
Sbjct: 1097 CEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPC 1152
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 11/80 (13%)
Query: 65 RSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD-------CG-NDFQCSTGRCIKMR 116
R + F Q + RC V + C + C D D+ CG +F+C G CI
Sbjct: 2565 RCKKTFRQCSNGRC---VSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNS 2621
Query: 117 LRCNGDNDCGDFSDEDDCES 136
RCN DC D SDE +C +
Sbjct: 2622 SRCNQFVDCEDASDEMNCSA 2641
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 29/83 (34%)
Query: 88 CVPTEPCEDAEDDCGND------------------FQCSTGR-CIKMRLRCNGDNDCGDF 128
C P D EDDCG++ F+C R C+ + +C+G ++CGD
Sbjct: 3666 CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDG 3725
Query: 129 SDEDDCESEPRPP------CRDR 145
+DE+DCE PP C+D+
Sbjct: 3726 TDEEDCE----PPTAHTTHCKDK 3744
Score = 41.2 bits (95), Expect = 0.003
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 24/101 (23%)
Query: 42 DCRMSPWSEWSQCD--PCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAED 99
DC+ + S+ + CD CL F+ N RC + +C + C D ED
Sbjct: 3398 DCQDN--SDEANCDIHVCLPSQFKCT--------NTNRCIPGIF---RCNGQDNCGDGED 3444
Query: 100 --DCG------NDFQCS-TGRCIKMRLRCNGDNDCGDFSDE 131
DC N FQCS T RCI C+ DNDC D SDE
Sbjct: 3445 ERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3485
Score = 37.4 bits (85), Expect = 0.037
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 9/63 (14%)
Query: 76 KRCTDAVGDR--RQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDED- 132
K C D + C+ C+D E F C +CI C+ D DC D SDE
Sbjct: 2798 KDCADGADESIAAGCLYNSTCDDRE------FMCQNRQCIPKHFVCDHDRDCADGSDESP 2851
Query: 133 DCE 135
+CE
Sbjct: 2852 ECE 2854
Score = 35.4 bits (80), Expect = 0.14
Identities = 17/45 (37%), Positives = 24/45 (53%), Gaps = 3/45 (6%)
Query: 103 NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCE---SEPRPPCRD 144
N F C +GRCI M C+ ++DC DE C SE + C++
Sbjct: 2699 NYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQN 2743
Score = 35.4 bits (80), Expect = 0.14
Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 4/42 (9%)
Query: 103 NDFQCSTGRCIKMRLRCNGDNDCGDFSDE-DDCESEPRPPCR 143
+ F C +CI +C+ ++DCGD SDE DC P CR
Sbjct: 3337 SQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDC---PEFKCR 3375
Score = 34.7 bits (78), Expect = 0.24
Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 2/40 (5%)
Query: 94 CEDAEDDCG--NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
C C ++F+C+ G CI L C+G C D SDE
Sbjct: 2517 CRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDE 2556
Score = 34.7 bits (78), Expect = 0.24
Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 19/75 (25%)
Query: 76 KRCTDAVGD--RRQCVPTEPCEDAEDDCGN----------------DFQC-STGRCIKMR 116
K C++A + +C+ + D DDCG+ F C T C+ R
Sbjct: 2732 KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPER 2791
Query: 117 LRCNGDNDCGDFSDE 131
C+GD DC D +DE
Sbjct: 2792 WLCDGDKDCADGADE 2806
Score = 32.0 bits (71), Expect = 1.5
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 16/75 (21%)
Query: 74 NGKR-CTDAVGDRRQCVP---TEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFS 129
+G+R C D + + P + C+ E +C T C+ M CNG DC D S
Sbjct: 48 DGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-----LGTELCVPMSRLCNGVQDCMDGS 102
Query: 130 DEDDCESEPRPPCRD 144
DE P CR+
Sbjct: 103 DEG-------PHCRE 110
Score = 32.0 bits (71), Expect = 1.5
Identities = 25/94 (26%), Positives = 36/94 (38%), Gaps = 31/94 (32%)
Query: 54 CDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD------------- 100
CDP ++ FG + RC + C CED D+
Sbjct: 1104 CDPSVK----------FGCKDSARC---ISKAWVCDGDNDCEDNSDEENCESLACRPPSH 1150
Query: 101 -CGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDD 133
C N+ T C+ C+G++DCGD SDE +
Sbjct: 1151 PCANN----TSVCLPPDKLCDGNDDCGDGSDEGE 1180
Score = 30.4 bits (67), Expect = 4.5
Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 1/32 (3%)
Query: 513 CQNGGTV-ILMDGKCLCACPFKFEGIACEISK 543
C+N GT + DG C C FEG CE++K
Sbjct: 4312 CENFGTCQMAADGSRQCRCTAYFEGSRCEVNK 4343
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 53.9 bits (128), Expect = 4e-07
Identities = 27/68 (39%), Positives = 34/68 (50%), Gaps = 8/68 (11%)
Query: 75 GKRCTDAVGDRRQCVPTEPCEDAEDD--CGN------DFQCSTGRCIKMRLRCNGDNDCG 126
G T + +C C+ ED+ CGN +F CS+GRCI CNG +DC
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
Query: 127 DFSDEDDC 134
D SDE DC
Sbjct: 181 DGSDELDC 188
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 9/81 (11%)
Query: 52 SQCDPCLRQMFRSRSIEVFGQFNGKR-CTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTG 110
++C+P Q R I + + +G C D D + CV E +DF C+ G
Sbjct: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDG-SDEKNCVKKTCAE-------SDFVCNNG 82
Query: 111 RCIKMRLRCNGDNDCGDFSDE 131
+C+ R +C+GD DC D SDE
Sbjct: 83 QCVPSRWKCDGDPDCEDGSDE 103
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/32 (53%), Positives = 23/32 (71%)
Query: 103 NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+ FQC+ GRCI + +C+GD DC D SDE +C
Sbjct: 36 SQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Score = 44.7 bits (104), Expect = 2e-04
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 15/69 (21%)
Query: 88 CVPTEPCEDAEDD----CG-----------NDFQCSTGRCIKMRLRCNGDNDCGDFSDED 132
C C D D+ CG ++ QC +G CI + RC+GD DC D SDE
Sbjct: 212 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 271
Query: 133 DCESEPRPP 141
+C S P
Sbjct: 272 NCPSRTCRP 280
Score = 43.1 bits (100), Expect = 7e-04
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 10/61 (16%)
Query: 88 CVPTEPCEDAEDD-------CG-NDFQCSTGRCIKMRLRCNGDNDCGDFSDE--DDCESE 137
C + C D D+ CG ++FQCST CI + C+ D DC D SDE + C +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 138 P 138
P
Sbjct: 233 P 233
Score = 40.4 bits (93), Expect = 0.004
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 8/65 (12%)
Query: 80 DAVGDRRQCVPTEPCEDAEDDCG--------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
+ + + +C C+D D+ + F+C G CI +CNG DC D SDE
Sbjct: 250 ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Query: 132 DDCES 136
+C++
Sbjct: 310 VNCKN 314
Score = 40.0 bits (92), Expect = 0.006
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 10/56 (17%)
Query: 86 RQCVPTEPCEDAEDD--CGN--------DFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
RQC C D D+ C N F+C +G CI + CN + DC D+SDE
Sbjct: 295 RQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 53.9 bits (128), Expect = 4e-07
Identities = 27/68 (39%), Positives = 34/68 (50%), Gaps = 8/68 (11%)
Query: 75 GKRCTDAVGDRRQCVPTEPCEDAEDD--CGN------DFQCSTGRCIKMRLRCNGDNDCG 126
G T + +C C+ ED+ CGN +F CS+GRCI CNG +DC
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
Query: 127 DFSDEDDC 134
D SDE DC
Sbjct: 181 DGSDELDC 188
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 9/81 (11%)
Query: 52 SQCDPCLRQMFRSRSIEVFGQFNGKR-CTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTG 110
++C+P Q R I + + +G C D D + CV E +DF C+ G
Sbjct: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDG-SDEKNCVKKTCAE-------SDFVCNNG 82
Query: 111 RCIKMRLRCNGDNDCGDFSDE 131
+C+ R +C+GD DC D SDE
Sbjct: 83 QCVPSRWKCDGDPDCEDGSDE 103
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/32 (53%), Positives = 23/32 (71%)
Query: 103 NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+ FQC+ GRCI + +C+GD DC D SDE +C
Sbjct: 36 SQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Score = 44.7 bits (104), Expect = 2e-04
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 15/69 (21%)
Query: 88 CVPTEPCEDAEDD----CG-----------NDFQCSTGRCIKMRLRCNGDNDCGDFSDED 132
C C D D+ CG ++ QC +G CI + RC+GD DC D SDE
Sbjct: 212 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 271
Query: 133 DCESEPRPP 141
+C S P
Sbjct: 272 NCPSRTCRP 280
Score = 43.1 bits (100), Expect = 7e-04
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 10/61 (16%)
Query: 88 CVPTEPCEDAEDD-------CG-NDFQCSTGRCIKMRLRCNGDNDCGDFSDE--DDCESE 137
C + C D D+ CG ++FQCST CI + C+ D DC D SDE + C +
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ 232
Query: 138 P 138
P
Sbjct: 233 P 233
Score = 40.4 bits (93), Expect = 0.004
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 8/65 (12%)
Query: 80 DAVGDRRQCVPTEPCEDAEDDCG--------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
+ + + +C C+D D+ + F+C G CI +CNG DC D SDE
Sbjct: 250 ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Query: 132 DDCES 136
+C++
Sbjct: 310 VNCKN 314
Score = 40.0 bits (92), Expect = 0.006
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 10/56 (17%)
Query: 86 RQCVPTEPCEDAEDD--CGN--------DFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
RQC C D D+ C N F+C +G CI + CN + DC D+SDE
Sbjct: 295 RQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 52.0 bits (123), Expect = 1e-06
Identities = 24/62 (38%), Positives = 33/62 (53%), Gaps = 15/62 (24%)
Query: 88 CVPTEPCEDAEDDCGN---------------DFQCSTGRCIKMRLRCNGDNDCGDFSDED 132
C+P D EDDCG+ ++ CS+G CI+ C+GDNDC D+SDE
Sbjct: 1131 CIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEA 1190
Query: 133 DC 134
+C
Sbjct: 1191 NC 1192
Score = 47.8 bits (112), Expect = 3e-05
Identities = 18/37 (48%), Positives = 25/37 (67%)
Query: 105 FQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPP 141
FQC G CI + +C+G +DCGD+SDE +CE+ P
Sbjct: 1330 FQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAP 1366
Score = 47.8 bits (112), Expect = 3e-05
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 13/61 (21%)
Query: 87 QCVPTEPCEDAEDD--CGN-----------DFQCSTGRCIKMRLRCNGDNDCGDFSDEDD 133
+C + C D D+ C N F+C G CI R +C+ +NDCGD+SDE D
Sbjct: 1343 KCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKD 1402
Query: 134 C 134
C
Sbjct: 1403 C 1403
Score = 45.8 bits (107), Expect = 1e-04
Identities = 20/42 (47%), Positives = 25/42 (59%), Gaps = 1/42 (2%)
Query: 94 CEDAEDDC-GNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C E+ C N ++CS G CI C+ DNDCGD SDE +C
Sbjct: 1071 CVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/62 (37%), Positives = 29/62 (46%), Gaps = 12/62 (19%)
Query: 88 CVPTEPCEDAEDDCG----------NDFQCSTGRCIKMRLRCNGDNDCGDFSDED--DCE 135
C C D D+ ++FQC G CI R C+GD DC D SDED +CE
Sbjct: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
Query: 136 SE 137
+
Sbjct: 1237 KK 1238
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/102 (30%), Positives = 41/102 (40%), Gaps = 19/102 (18%)
Query: 42 DCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD- 100
DCR WS+ + C ++ + F NG + R C C+D D+
Sbjct: 1182 DCR--DWSDEANCTA----IYHTCEASNFQCRNGH----CIPQRWACDGDTDCQDGSDED 1231
Query: 101 -------CGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCE 135
C N F+C G CI C+G DC D SDE CE
Sbjct: 1232 PVNCEKKC-NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCE 1272
Score = 43.1 bits (100), Expect = 7e-04
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 8/59 (13%)
Query: 78 CTDAVGDRRQCVPTEPCEDAEDDCGNDFQCS-TGRCIKMRLRCNGDNDCGDFSDEDDCE 135
C D + D R C PT C D F+C +G CI + +C+ ++DCGD SDE CE
Sbjct: 1103 CGD-MSDERNC-PTTIC-----DLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCE 1154
Score = 40.0 bits (92), Expect = 0.006
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 12/64 (18%)
Query: 86 RQCVPTEPCEDAEDDCG-----------NDFQCSTGR-CIKMRLRCNGDNDCGDFSDEDD 133
++C + C+D D+ +FQC G CI + RC+G DC D SDE
Sbjct: 1489 KRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKA 1548
Query: 134 CESE 137
C E
Sbjct: 1549 CSDE 1552
Score = 38.1 bits (87), Expect = 0.021
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 21/79 (26%)
Query: 77 RCTDA--VGDRRQCVPTEPCEDAED--DCG-----------------NDFQCSTGRCIKM 115
RC + + +R +C C D D DCG N ++CS+G C+
Sbjct: 1375 RCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMD 1434
Query: 116 RLRCNGDNDCGDFSDEDDC 134
C+G DC D SDE+ C
Sbjct: 1435 TWVCDGYRDCADGSDEEAC 1453
Score = 32.0 bits (71), Expect = 1.5
Identities = 15/43 (34%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 104 DFQCSTGR-CIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDR 145
+F+C + CI RC+G DC D DE +C + C R
Sbjct: 1475 EFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSR 1517
Score = 30.8 bits (68), Expect = 3.4
Identities = 23/80 (28%), Positives = 33/80 (41%), Gaps = 15/80 (18%)
Query: 74 NGKRCTDA--VGDRRQCVPTEPCEDAEDD------CGN--DFQCSTGR-CIKMRLRCNGD 122
NG RC + + + C C D D+ C + DF C + C+ + C+G
Sbjct: 1240 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGI 1299
Query: 123 NDCGDFSDED----DCESEP 138
C D SDED C +P
Sbjct: 1300 IQCRDGSDEDAAFAGCSQDP 1319
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 52.0 bits (123), Expect = 1e-06
Identities = 23/57 (40%), Positives = 31/57 (54%), Gaps = 5/57 (8%)
Query: 87 QCVPTEPCEDAEDDCG-----NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEP 138
QC C+D D+ N F C TG+C+ L C+G +DCGD SDE +C+ P
Sbjct: 288 QCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNP 344
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/33 (54%), Positives = 24/33 (72%)
Query: 102 GNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
G +F C++G CI +L+CNG NDC D+SDE C
Sbjct: 272 GENFLCASGICIPGKLQCNGYNDCDDWSDEAHC 304
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 15/64 (23%)
Query: 96 DAEDDCGN-------------DFQCSTGRCIKMRLRCNGDNDCGDFSDEDD--CESEPRP 140
D DDCG+ + +C GRCI M C+GD+DC D SDE + C S+
Sbjct: 326 DGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLV 385
Query: 141 PCRD 144
CR+
Sbjct: 386 ECRN 389
Score = 43.9 bits (102), Expect = 4e-04
Identities = 20/56 (35%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 84 DRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPR 139
D + C+ P E E+ + F+C +G+C+ RC+G DC D SDE++C + R
Sbjct: 566 DNQTCLM--PDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKER 619
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 14/65 (21%)
Query: 83 GDRRQCVPTEPCEDAEDDCGND-------------FQCSTGRCIKMRLRCNGDNDCGDFS 129
GD R C+ E D + DC + +C G+CI +C+GD DC D S
Sbjct: 351 GDGR-CIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGS 409
Query: 130 DEDDC 134
DE++C
Sbjct: 410 DEENC 414
Score = 38.5 bits (88), Expect = 0.016
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 3/41 (7%)
Query: 94 CEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C +DD + +C+ C+ L C+G+ DC D SDE DC
Sbjct: 652 CSFCQDD---ELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 35.4 bits (80), Expect = 0.14
Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 7/56 (12%)
Query: 86 RQCVPTEPCEDAEDD--CG----NDFQC-STGRCIKMRLRCNGDNDCGDFSDEDDC 134
R+C C+D D+ CG + ++C S +C+K + C+G DC D+ DE +C
Sbjct: 597 RRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/76 (38%), Positives = 40/76 (52%), Gaps = 8/76 (10%)
Query: 66 SIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCG------NDFQCSTGRCIKMRLRC 119
S + F F G+ D + +C CED D+ + FQC++G+CI LRC
Sbjct: 1250 SPQQFTCFTGE--IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRC 1307
Query: 120 NGDNDCGDFSDEDDCE 135
NGD +C D SDE +CE
Sbjct: 1308 NGDANCQDKSDEKNCE 1323
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/107 (28%), Positives = 44/107 (41%), Gaps = 21/107 (19%)
Query: 49 SEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCG------ 102
S+ C C F+ S GQ C D +C C+D D+
Sbjct: 1280 SDELNCPVCSESQFQCAS----GQ-----CIDGA---LRCNGDANCQDKSDEKNCEVLCL 1327
Query: 103 -NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC--ESEPRPPCRDRV 146
+ F+C+ G+CI +C+ + DC D SDE DC EP P + V
Sbjct: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTV 1374
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/75 (38%), Positives = 38/75 (50%), Gaps = 16/75 (21%)
Query: 88 CVPTEPCEDAEDD---CGN--------DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCES 136
C C DA D+ CG+ +F+C GRCI C+GDNDCGD SDED
Sbjct: 2883 CDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDED---- 2938
Query: 137 EPRPPCRDRVVEESE 151
R C+++ +SE
Sbjct: 2939 -KRHQCQNQNCSDSE 2952
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 9/89 (10%)
Query: 55 DPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCG---------NDF 105
+P M + + F +F+ K + C + C D D+ G DF
Sbjct: 3666 EPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDF 3725
Query: 106 QCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+C CI +R +C+G NDCGD SDE++C
Sbjct: 3726 RCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 15/64 (23%)
Query: 86 RQCVPTEPCEDAEDDCGND---------------FQCSTGRCIKMRLRCNGDNDCGDFSD 130
+QC+P+ D +DCG++ FQC++G C+ L+C+G DC D SD
Sbjct: 3769 QQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASD 3828
Query: 131 EDDC 134
E DC
Sbjct: 3829 EADC 3832
Score = 49.7 bits (117), Expect = 7e-06
Identities = 24/59 (40%), Positives = 30/59 (50%), Gaps = 8/59 (13%)
Query: 88 CVPTEPCEDAEDD-------CGN-DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEP 138
C C+D D+ CG F C +GRCI C+G++DC D DED CES P
Sbjct: 202 CDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP 260
Score = 49.7 bits (117), Expect = 7e-06
Identities = 29/77 (37%), Positives = 39/77 (50%), Gaps = 15/77 (19%)
Query: 72 QFNGKRCTDAVGDRRQCVPTEPCEDAEDD----CGN------DFQCSTGRCIKMRLRCNG 121
Q KRC + + QC CED D+ C + F+C+ GRCI +C+
Sbjct: 3600 QCANKRC---IPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDV 3656
Query: 122 DNDCGDFSDE--DDCES 136
DNDCGD SDE ++C S
Sbjct: 3657 DNDCGDHSDEPIEECMS 3673
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/86 (33%), Positives = 38/86 (44%), Gaps = 23/86 (26%)
Query: 72 QFNGKRCTDA----VGDR---RQCVPTEPCEDAEDDCG----------------NDFQCS 108
Q + C+D+ V DR R+C+P D + DC N+F C
Sbjct: 2942 QCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCG 3001
Query: 109 TGRCIKMRLRCNGDNDCGDFSDEDDC 134
G CI RC+ NDCGD+SDE C
Sbjct: 3002 YGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/61 (37%), Positives = 29/61 (47%), Gaps = 7/61 (11%)
Query: 78 CTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESE 137
C + CVP + C + F C G CI C+ DNDCGD SDE DC ++
Sbjct: 1256 CLYGSDEHNACVP-KTCPSSY------FHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQ 1308
Query: 138 P 138
P
Sbjct: 1309 P 1309
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/119 (29%), Positives = 51/119 (42%), Gaps = 21/119 (17%)
Query: 35 SGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRC--TDAVGDRRQCVPTE 92
+G SHI C P QC P + + + + NG+RC + +C+ E
Sbjct: 2659 NGGCSHI-CAPGPNGAECQC-PHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEE 2716
Query: 93 PCEDAEDDCGND-----------------FQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
D ++DCG+ F C+ GRC++ RC+ NDCGD SDE C
Sbjct: 2717 WKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Score = 47.4 bits (111), Expect = 4e-05
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 19/79 (24%)
Query: 76 KRCTDAVGDRR----QCVPTEPCEDAEDDCGN---------------DFQCSTGRCIKMR 116
+R VGD R C+P D ++DCG+ +F+C +CI R
Sbjct: 3716 ERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSR 3775
Query: 117 LRCNGDNDCGDFSDEDDCE 135
C+ NDCGD SDE DCE
Sbjct: 3776 WICDHYNDCGDNSDERDCE 3794
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/72 (37%), Positives = 31/72 (43%), Gaps = 18/72 (25%)
Query: 88 CVPTEPCEDAEDDCG---------------NDFQCSTGRCIKMRLRCNGDNDCGDFSDE- 131
C+P D +DCG N F C GRCI C+ DNDCGD SDE
Sbjct: 3005 CIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDEL 3064
Query: 132 -DDCESEPRPPC 142
C + P P C
Sbjct: 3065 MHLCHT-PEPTC 3075
Score = 44.7 bits (104), Expect = 2e-04
Identities = 25/77 (32%), Positives = 32/77 (41%), Gaps = 20/77 (25%)
Query: 88 CVPTEPCEDAEDDCG------------------NDFQCSTGRCIKMRLRCNGDNDCGDFS 129
C+P D +DDCG N F+C RCI CNG +DCGD +
Sbjct: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 3913
Query: 130 D--EDDCESEPRPPCRD 144
D E+ C PC +
Sbjct: 3914 DETEEHCRKPTPKPCTE 3930
Score = 44.3 bits (103), Expect = 3e-04
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 7/57 (12%)
Query: 78 CTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C D D + C TE C+ ++ F C RCI + C+GD DC D SDE C
Sbjct: 1134 CGDG-SDEKNCNSTETCQPSQ------FNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Score = 43.1 bits (100), Expect = 7e-04
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 16/65 (24%)
Query: 87 QCVPT-------EPCEDAED---DCG------NDFQCSTGRCIKMRLRCNGDNDCGDFSD 130
QC+P + C+D D DC + CS G+CI RC+ DC D +D
Sbjct: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGAD 138
Query: 131 EDDCE 135
E+DC+
Sbjct: 139 ENDCQ 143
Score = 42.7 bits (99), Expect = 9e-04
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 10/67 (14%)
Query: 88 CVPTEPCEDAEDD--CG--------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESE 137
C + C D D+ CG + F C G CI RC+ NDC D SDE +C +
Sbjct: 1045 CDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTH 1104
Query: 138 PRPPCRD 144
C D
Sbjct: 1105 APASCLD 1111
Score = 42.7 bits (99), Expect = 9e-04
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 13/81 (16%)
Query: 72 QFN--GKRCTDAVGDRRQCVPTEPCEDAEDDCG-------NDFQCSTG-RCIKMRLRCNG 121
QFN RC D C + C D D+ G + F+C++G +CI + RC+G
Sbjct: 1153 QFNCPNHRCIDL---SFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDG 1209
Query: 122 DNDCGDFSDEDDCESEPRPPC 142
DC D SDE C + P C
Sbjct: 1210 VFDCSDNSDEAGCPTRPPGMC 1230
Score = 42.7 bits (99), Expect = 9e-04
Identities = 24/58 (41%), Positives = 27/58 (46%), Gaps = 3/58 (5%)
Query: 90 PTEPCEDAEDDCGN--DFQCSTG-RCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRD 144
P E C + C N +F C T RCI CNG +DC D SDE CE P D
Sbjct: 3667 PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD 3724
Score = 42.7 bits (99), Expect = 9e-04
Identities = 21/87 (24%), Positives = 36/87 (41%), Gaps = 20/87 (22%)
Query: 84 DRRQCVPTEPCEDAEDDCGN--------------------DFQCSTGRCIKMRLRCNGDN 123
D +C+ + + DDCG+ +++C G CI C+ +
Sbjct: 3892 DNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDAD 3951
Query: 124 DCGDFSDEDDCESEPRPPCRDRVVEES 150
DCGD+SDE C C + + E++
Sbjct: 3952 DCGDWSDELGCNKGKERTCAENICEQN 3978
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 7/48 (14%)
Query: 94 CEDAEDDCG-------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C D+ D+ N+F C G CI C+ DNDC D SDE C
Sbjct: 170 CRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Score = 41.2 bits (95), Expect = 0.003
Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 17/61 (27%)
Query: 88 CVPTEPCEDAEDDCGN-----------------DFQCSTGRCIKMRLRCNGDNDCGDFSD 130
C+P D ++DCG+ +FQC++GRCI C+ + DC D SD
Sbjct: 2835 CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASD 2894
Query: 131 E 131
E
Sbjct: 2895 E 2895
Score = 41.2 bits (95), Expect = 0.003
Identities = 19/42 (45%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query: 94 CEDAEDDCG-NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C E C ++F+C GRCI+M CN +DC D SDE C
Sbjct: 3068 CHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 40.4 bits (93), Expect = 0.004
Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 18/68 (26%)
Query: 87 QCVPTEPCEDAEDDC--GND----------------FQCSTGRCIKMRLRCNGDNDCGDF 128
+C+P D +DC G+D + C +CI C+ DNDCGD
Sbjct: 1078 ECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDG 1137
Query: 129 SDEDDCES 136
SDE +C S
Sbjct: 1138 SDEKNCNS 1145
Score = 39.7 bits (91), Expect = 0.007
Identities = 28/85 (32%), Positives = 38/85 (44%), Gaps = 16/85 (18%)
Query: 71 GQFNGKRCTDA--VGDRRQCVPTEPCEDAEDD---------C-GNDFQCSTGRCIKMRLR 118
GQF +C+D + C + C D D+ C N++QC+ RCI +
Sbjct: 3556 GQF---QCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 3612
Query: 119 CNGDNDCGDFSDEDDCESEPRPPCR 143
C+ NDC D SDED R CR
Sbjct: 3613 CDTFNDCEDNSDEDSSHCASR-TCR 3636
Score = 38.9 bits (89), Expect = 0.013
Identities = 24/71 (33%), Positives = 32/71 (45%), Gaps = 15/71 (21%)
Query: 77 RCTDA--VGDRRQCVPTEPCEDAED--DC-----------GNDFQCSTGRCIKMRLRCNG 121
+CT V +C + C DA D DC F+C CI +C+G
Sbjct: 3804 QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDG 3863
Query: 122 DNDCGDFSDED 132
D+DCGD SDE+
Sbjct: 3864 DDDCGDGSDEE 3874
Score = 38.5 bits (88), Expect = 0.016
Identities = 30/102 (29%), Positives = 41/102 (40%), Gaps = 32/102 (31%)
Query: 84 DRRQCVPTEPCEDAEDDCG------------------NDFQCSTG-----RCIKMRLRCN 120
D +C+P+E D ++DCG ++F C RCI C+
Sbjct: 2914 DGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCD 2973
Query: 121 GDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINI 162
GD DC D DE+ C R E+E T GYG+ I
Sbjct: 2974 GDVDCTDGYDENQ-------NCTRRTCSENEF--TCGYGLCI 3006
Score = 38.1 bits (87), Expect = 0.021
Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 18/72 (25%)
Query: 79 TDAVGDRRQCVPTEPCEDAEDDCGN----------DFQCSTGR--------CIKMRLRCN 120
T+ + + R+C+P E + D+C + D C +G CI C+
Sbjct: 2784 TEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCD 2843
Query: 121 GDNDCGDFSDED 132
GDNDCGD SDE+
Sbjct: 2844 GDNDCGDNSDEN 2855
Score = 37.7 bits (86), Expect = 0.028
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 1/42 (2%)
Query: 93 PCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
P E D + F+C +G CI RC+G DC D +DE C
Sbjct: 22 PASGQECDSAH-FRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
Score = 36.6 bits (83), Expect = 0.062
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 95 EDAEDDCGN-DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
E + CG F C GRC+ C+G +DC D SDE C
Sbjct: 1020 EPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Score = 35.4 bits (80), Expect = 0.14
Identities = 22/58 (37%), Positives = 28/58 (48%), Gaps = 10/58 (17%)
Query: 87 QCVPTEPCEDAEDDCG--------NDFQC-STGRCIKMRLRCNGDNDCGDFSDE-DDC 134
+C T+ C D D+ G F+C S G+CI C+ D DC D SDE DC
Sbjct: 46 RCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDC 103
Score = 35.0 bits (79), Expect = 0.18
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 11/59 (18%)
Query: 87 QCVPTEPCEDAEDDCG---------NDFQCSTGRCIKMRLRCNGDNDCGD--FSDEDDC 134
+C C D D+ G +F C+ RCI CNG ++C D SDE +C
Sbjct: 2759 RCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNC 2817
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 17/63 (26%)
Query: 87 QCVPTE-------PCEDAEDDCGNDFQ--------CSTGRCIKMRLRCNGDNDCGDFSDE 131
QC+P+E C D D+ ND Q C G C +C+ DC D SDE
Sbjct: 119 QCIPSEYRCDHVRDCPDGADE--NDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDE 176
Query: 132 DDC 134
+C
Sbjct: 177 INC 179
Score = 30.0 bits (66), Expect = 5.8
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 7/44 (15%)
Query: 88 CVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
C+P C + C N+ +CI + +C+G DC D SDE
Sbjct: 3508 CMPM--CSSTQFLCANN-----EKCIPIWWKCDGQKDCSDGSDE 3544
Score = 29.6 bits (65), Expect = 7.6
Identities = 21/70 (30%), Positives = 29/70 (41%), Gaps = 15/70 (21%)
Query: 74 NGKRCTDAVGDRRQCVPTEPCEDAEDDCG-----------NDFQCST-GRCIKMRLRCNG 121
+G +C +G +C C D D+ G ++FQC G CI C+G
Sbjct: 1196 SGDKC---IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDG 1252
Query: 122 DNDCGDFSDE 131
DC SDE
Sbjct: 1253 HPDCLYGSDE 1262
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 51.2 bits (121), Expect = 2e-06
Identities = 23/63 (36%), Positives = 35/63 (55%), Gaps = 6/63 (9%)
Query: 80 DAVGDRRQCVPTEPCEDAEDDCG------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDD 133
D + +C C+D D+ G F C+ G+C+ +RLRC+G+ DC D SDE D
Sbjct: 1272 DCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEAD 1331
Query: 134 CES 136
C++
Sbjct: 1332 CDA 1334
Score = 46.2 bits (108), Expect = 8e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 11/96 (11%)
Query: 77 RCTDAVGDRRQCVPTEPCEDAED--DCG-----NDFQCSTGRCIKMRLRCNGDNDCGDFS 129
+C D R +C C+D D DC N F+C++G+C+ ++ +C+ DC D S
Sbjct: 1309 QCVDL---RLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGS 1365
Query: 130 DEDDCESEPRPPCRDRVVEESELARTAGYGINILGM 165
DE CE +PP D S + G +++ M
Sbjct: 1366 DELMCEI-TKPPSDDSPAHSSAIGPVIGIILSLFVM 1400
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 51.2 bits (121), Expect = 2e-06
Identities = 21/42 (50%), Positives = 26/42 (61%)
Query: 96 DAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESE 137
D+ D C F C TGRCI+ LRC+G DC D SDE +C +
Sbjct: 448 DSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCD 489
Score = 47.8 bits (112), Expect = 3e-05
Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 88 CVPTEPCEDAEDDCG-----NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C C D D+ G F+CS G+C+ +CNG +DCGD SDE C
Sbjct: 508 CDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Score = 38.5 bits (88), Expect = 0.016
Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 14/73 (19%)
Query: 77 RCTDA--VGDRRQCVPTEPCEDAEDDCG-----------NDFQCSTGRCI-KMRLRCNGD 122
RC++ + +QC + C D D+ + ++C G C+ K C+G
Sbjct: 531 RCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGK 590
Query: 123 NDCGDFSDEDDCE 135
DC D SDE DC+
Sbjct: 591 EDCSDGSDEKDCD 603
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 49.7 bits (117), Expect = 7e-06
Identities = 25/52 (48%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 93 PCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRD 144
P +D E D FQC RCI RC+ D+DC D SDEDDC P+ C D
Sbjct: 43 PAKDCEKD---QFQCRNERCIPSVWRCDEDDDCLDHSDEDDC---PKKTCAD 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 11/70 (15%)
Query: 72 QFNGKRCTDAVGDRRQCVPTEPCEDA--EDDC------GNDFQCSTGRCIKMRLRCNGDN 123
Q +RC +V +C + C D EDDC +DF C G CI R +C+G+
Sbjct: 53 QCRNERCIPSVW---RCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
Query: 124 DCGDFSDEDD 133
+C D SDE +
Sbjct: 110 ECPDGSDESE 119
Score = 45.1 bits (105), Expect = 2e-04
Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 10/66 (15%)
Query: 87 QCVPTEPCEDAEDDCG-------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPR 139
+C + CE D+ G ++FQC C+ C+GD+DCGD SDE C
Sbjct: 147 RCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCAD--- 203
Query: 140 PPCRDR 145
P C R
Sbjct: 204 PACGPR 209
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/82 (32%), Positives = 35/82 (42%), Gaps = 23/82 (28%)
Query: 82 VGDRRQCVPTEPCEDAEDD----CG----------------NDFQCSTGRCIKMRLRCNG 121
+ +R C CED D+ CG + F C +G C+ + RC+G
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDG 281
Query: 122 DNDCGDFSDEDDCESEPRPPCR 143
D DC D SDE DC P CR
Sbjct: 282 DRDCKDKSDEADC---PLGTCR 300
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 8/56 (14%)
Query: 87 QCVPTEPCEDAED--DC------GNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+C C+D D DC G++FQC G C+ CN + DC D SDE C
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 30.4 bits (67), Expect = 4.5
Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 12/65 (18%)
Query: 82 VGDRRQCVPTEPCEDAEDDC----------GNDFQC--STGRCIKMRLRCNGDNDCGDFS 129
+ +R +C E C D D+ C ++ +C+ RC+G+ DC +
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA 158
Query: 130 DEDDC 134
DE C
Sbjct: 159 DEAGC 163
Score = 30.0 bits (66), Expect = 5.8
Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 18/64 (28%)
Query: 86 RQCVPTEPCEDAEDDCGN---------------DFQCST---GRCIKMRLRCNGDNDCGD 127
R C+ D +DDCG+ +F+C G CI R C+ DC D
Sbjct: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Query: 128 FSDE 131
SDE
Sbjct: 237 RSDE 240
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 49.7 bits (117), Expect = 7e-06
Identities = 25/52 (48%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 93 PCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRD 144
P +D E D FQC RCI RC+ D+DC D SDEDDC P+ C D
Sbjct: 43 PAKDCEKD---QFQCRNERCIPSVWRCDEDDDCLDHSDEDDC---PKKTCAD 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 11/70 (15%)
Query: 72 QFNGKRCTDAVGDRRQCVPTEPCEDA--EDDC------GNDFQCSTGRCIKMRLRCNGDN 123
Q +RC +V +C + C D EDDC +DF C G CI R +C+G+
Sbjct: 53 QCRNERCIPSVW---RCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
Query: 124 DCGDFSDEDD 133
+C D SDE +
Sbjct: 110 ECPDGSDESE 119
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/65 (33%), Positives = 27/65 (41%), Gaps = 17/65 (26%)
Query: 87 QCVPTEPCEDAEDDC-----------------GNDFQCSTGRCIKMRLRCNGDNDCGDFS 129
+CVP D E DC G++FQC G C+ CN + DC D S
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
Query: 130 DEDDC 134
DE C
Sbjct: 200 DEAGC 204
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 49.7 bits (117), Expect = 7e-06
Identities = 25/52 (48%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 93 PCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRD 144
P +D E D FQC RCI RC+ D+DC D SDEDDC P+ C D
Sbjct: 43 PAKDCEKD---QFQCRNERCIPSVWRCDEDDDCLDHSDEDDC---PKKTCAD 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 11/70 (15%)
Query: 72 QFNGKRCTDAVGDRRQCVPTEPCEDA--EDDC------GNDFQCSTGRCIKMRLRCNGDN 123
Q +RC +V +C + C D EDDC +DF C G CI R +C+G+
Sbjct: 53 QCRNERCIPSVW---RCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
Query: 124 DCGDFSDEDD 133
+C D SDE +
Sbjct: 110 ECPDGSDESE 119
Score = 30.4 bits (67), Expect = 4.5
Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 12/65 (18%)
Query: 82 VGDRRQCVPTEPCEDAEDDC----------GNDFQC--STGRCIKMRLRCNGDNDCGDFS 129
+ +R +C E C D D+ C ++ +C+ RC+G+ DC +
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA 158
Query: 130 DEDDC 134
DE C
Sbjct: 159 DEAGC 163
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 49.7 bits (117), Expect = 7e-06
Identities = 25/52 (48%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 93 PCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRD 144
P +D E D FQC RCI RC+ D+DC D SDEDDC P+ C D
Sbjct: 43 PAKDCEKD---QFQCRNERCIPSVWRCDEDDDCLDHSDEDDC---PKKTCAD 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 11/70 (15%)
Query: 72 QFNGKRCTDAVGDRRQCVPTEPCEDA--EDDC------GNDFQCSTGRCIKMRLRCNGDN 123
Q +RC +V +C + C D EDDC +DF C G CI R +C+G+
Sbjct: 53 QCRNERCIPSVW---RCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
Query: 124 DCGDFSDEDD 133
+C D SDE +
Sbjct: 110 ECPDGSDESE 119
Score = 45.1 bits (105), Expect = 2e-04
Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 10/66 (15%)
Query: 87 QCVPTEPCEDAEDDCG-------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPR 139
+C + CE D+ G ++FQC C+ C+GD+DCGD SDE C
Sbjct: 147 RCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCAD--- 203
Query: 140 PPCRDR 145
P C R
Sbjct: 204 PACGPR 209
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/82 (32%), Positives = 35/82 (42%), Gaps = 23/82 (28%)
Query: 82 VGDRRQCVPTEPCEDAEDD----CG----------------NDFQCSTGRCIKMRLRCNG 121
+ +R C CED D+ CG + F C +G C+ + RC+G
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDG 281
Query: 122 DNDCGDFSDEDDCESEPRPPCR 143
D DC D SDE DC P CR
Sbjct: 282 DRDCKDKSDEADC---PLGTCR 300
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 8/56 (14%)
Query: 87 QCVPTEPCEDAED--DC------GNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+C C+D D DC G++FQC G C+ CN + DC D SDE C
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 30.4 bits (67), Expect = 4.5
Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 12/65 (18%)
Query: 82 VGDRRQCVPTEPCEDAEDDC----------GNDFQC--STGRCIKMRLRCNGDNDCGDFS 129
+ +R +C E C D D+ C ++ +C+ RC+G+ DC +
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA 158
Query: 130 DEDDC 134
DE C
Sbjct: 159 DEAGC 163
Score = 30.0 bits (66), Expect = 5.8
Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 18/64 (28%)
Query: 86 RQCVPTEPCEDAEDDCGN---------------DFQCST---GRCIKMRLRCNGDNDCGD 127
R C+ D +DDCG+ +F+C G CI R C+ DC D
Sbjct: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Query: 128 FSDE 131
SDE
Sbjct: 237 RSDE 240
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 10/65 (15%)
Query: 88 CVPTEPCEDAED--DCG-------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESE- 137
C E CED D DCG N+F C G C RC+GD DC D +DE +C ++
Sbjct: 304 CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 363
Query: 138 PRPPC 142
P C
Sbjct: 364 PEEVC 368
Score = 40.4 bits (93), Expect = 0.004
Identities = 20/43 (46%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 101 CG-NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPC 142
CG + C G CI C+G DC D SDE DC P PPC
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDC--GPPPPC 325
Score = 36.6 bits (83), Expect = 0.062
Identities = 27/95 (28%), Positives = 30/95 (31%), Gaps = 39/95 (41%)
Query: 78 CTDAVGDRRQCVPTEPCEDAEDDCGN------------DFQC------------------ 107
C D D C P PCE E CGN DF C
Sbjct: 310 CEDG-SDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVC 368
Query: 108 --------STGRCIKMRLRCNGDNDCGDFSDEDDC 134
ST CI C+ ++DC D SDE C
Sbjct: 369 GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 33.1 bits (74), Expect = 0.69
Identities = 19/49 (38%), Positives = 24/49 (48%), Gaps = 7/49 (14%)
Query: 89 VPTEP--CEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCE 135
VP P C +AE C S C+ + RC+ DC D SDE +CE
Sbjct: 192 VPQFPRACTEAEFACH-----SYNECVALEYRCDRRPDCRDMSDELNCE 235
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 47.8 bits (112), Expect = 3e-05
Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 98 EDDCGND-FQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPP 141
E +C D F+C G+CI +CN ++CGD SDE+ C E PP
Sbjct: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPP 188
Score = 37.0 bits (84), Expect = 0.048
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 104 DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+F C RC+ C+ +DCGD SDE++C
Sbjct: 436 NFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 33.9 bits (76), Expect = 0.40
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 9/70 (12%)
Query: 74 NGKRCTDAVGDRRQCVP--TEPCEDAEDDCG-NDFQCSTG-----RCIKMRLRCNGDNDC 125
N C D+ D C P A C N FQC + C+ L+C+G+ DC
Sbjct: 168 NMDECGDS-SDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDC 226
Query: 126 GDFSDEDDCE 135
D DE DC+
Sbjct: 227 LDLGDEIDCD 236
Score = 29.3 bits (64), Expect = 10.0
Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 7/58 (12%)
Query: 84 DRRQCVPTEPCEDAEDDCG------NDFQCS-TGRCIKMRLRCNGDNDCGDFSDEDDC 134
++++C C + D+ +F CS G C RCN N C + SDE +C
Sbjct: 372 EQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 47.8 bits (112), Expect = 3e-05
Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 98 EDDCGND-FQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPP 141
E +C D F+C G+CI +CN ++CGD SDE+ C E PP
Sbjct: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPP 207
Score = 37.0 bits (84), Expect = 0.048
Identities = 13/31 (41%), Positives = 19/31 (61%)
Query: 104 DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+F C RC+ C+ +DCGD SDE++C
Sbjct: 455 NFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 33.9 bits (76), Expect = 0.40
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 9/70 (12%)
Query: 74 NGKRCTDAVGDRRQCVP--TEPCEDAEDDCG-NDFQCSTG-----RCIKMRLRCNGDNDC 125
N C D+ D C P A C N FQC + C+ L+C+G+ DC
Sbjct: 187 NMDECGDS-SDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDC 245
Query: 126 GDFSDEDDCE 135
D DE DC+
Sbjct: 246 LDLGDEIDCD 255
Score = 29.3 bits (64), Expect = 10.0
Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 7/58 (12%)
Query: 84 DRRQCVPTEPCEDAEDDCG------NDFQCS-TGRCIKMRLRCNGDNDCGDFSDEDDC 134
++++C C + D+ +F CS G C RCN N C + SDE +C
Sbjct: 391 EQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 45.4 bits (106), Expect = 1e-04
Identities = 22/47 (46%), Positives = 28/47 (59%), Gaps = 2/47 (4%)
Query: 94 CEDAEDDCGNDF-QCSTG-RCIKMRLRCNGDNDCGDFSDEDDCESEP 138
C A+ CG F C++G CI R RCNG DC D SDE++C + P
Sbjct: 64 CPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANP 110
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 10/66 (15%)
Query: 85 RRQCVPTEPCEDAEDD---CGNDFQCSTGR-------CIKMRLRCNGDNDCGDFSDEDDC 134
R +C E C D D+ N CST R CI C+G N+C D SDE+ C
Sbjct: 88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Query: 135 ESEPRP 140
ES P
Sbjct: 148 ESSQEP 153
Score = 38.9 bits (89), Expect = 0.013
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 93 PCEDAEDDCG--NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
P + ++C +F CS GRCI +C+G DC D SDE +C
Sbjct: 21 PGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC 64
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 33 ESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTE 92
ES + + C+ +S + + C+ Q +R +G+ D D + C P
Sbjct: 58 ESQETCLSVTCKSGDFSCGGRVNRCIPQFWRC---------DGQVDCDNGSDEQGCPPKT 108
Query: 93 PCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+D +F+C G+CI + C+ D DC D SDE C
Sbjct: 109 CSQD-------EFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
Score = 42.7 bits (99), Expect = 9e-04
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 77 RCTDA--VGDRRQCVPTEPCEDAEDDCG----------NDFQCSTGRCIKMRLRCNGDND 124
+C+D + RQC C+D D+ G N F+C +G CI + CN D
Sbjct: 242 QCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD 301
Query: 125 CGDFSDE 131
C D+SDE
Sbjct: 302 CRDWSDE 308
Score = 39.7 bits (91), Expect = 0.007
Identities = 15/31 (48%), Positives = 20/31 (64%)
Query: 104 DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+F C +G CI RC+G DC D SDE++C
Sbjct: 201 EFHCLSGECIHSSWRCDGGPDCKDKSDEENC 231
Score = 38.9 bits (89), Expect = 0.013
Identities = 20/56 (35%), Positives = 28/56 (50%), Gaps = 8/56 (14%)
Query: 87 QCVPTEPCEDAEDD--CG------NDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
+C C+D D+ C ++FQCS G CI +C+ + DC D SDE C
Sbjct: 215 RCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 270
Score = 37.7 bits (86), Expect = 0.028
Identities = 21/51 (41%), Positives = 26/51 (50%), Gaps = 14/51 (27%)
Query: 81 AVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDE 131
AVGDR CE N+FQC G+CI + C+G +C D SDE
Sbjct: 22 AVGDR--------CER------NEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Score = 37.4 bits (85), Expect = 0.037
Identities = 24/65 (36%), Positives = 28/65 (43%), Gaps = 10/65 (15%)
Query: 77 RCTDAVGDRRQ--CVPTEPCEDAEDD-------CGN-DFQCSTGRCIKMRLRCNGDNDCG 126
RC D RQ C C D D+ CG FQC++ CI C+ D DC
Sbjct: 115 RCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE 174
Query: 127 DFSDE 131
D SDE
Sbjct: 175 DGSDE 179
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 44.7 bits (104), Expect = 2e-04
Identities = 20/44 (45%), Positives = 25/44 (56%)
Query: 104 DFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVV 147
+FQC RC+ RC+G + CGD SDE C S+P P R V
Sbjct: 144 EFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPV 187
Score = 36.2 bits (82), Expect = 0.082
Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 10/57 (17%)
Query: 78 CTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDC 134
C D D R+C +P +F+C +C+ C+G DC D SDE DC
Sbjct: 387 CADGA-DERRCRHCQP---------GNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Score = 33.9 bits (76), Expect = 0.40
Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 9/69 (13%)
Query: 74 NGKRCTDAVGDRRQCVPTE-PCEDAEDDCGNDFQCSTG---RCIKMRLRCNGDNDCGDFS 129
NG+ R C+P + PC G+ G RC RC+G DC D +
Sbjct: 294 NGRGFNATYHVRGYCLPWDRPC-----GLGSGLGAGEGLGERCYSEAQRCDGSWDCADGT 348
Query: 130 DEDDCESEP 138
DE+DC P
Sbjct: 349 DEEDCPGCP 357
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 43.9 bits (102), Expect = 4e-04
Identities = 20/38 (52%), Positives = 25/38 (65%), Gaps = 1/38 (2%)
Query: 105 FQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPC 142
F+CS+G C+ RC+G NDC D SDE C S P+P C
Sbjct: 363 FRCSSGLCVPQAQRCDGVNDCFDESDELFCVS-PQPAC 399
Score = 39.7 bits (91), Expect = 0.007
Identities = 20/65 (30%), Positives = 28/65 (43%), Gaps = 7/65 (10%)
Query: 84 DRRQCVPTEPCEDAEDDCGNDFQCSTGRCI-KMRLRCNGDNDCGDFSDEDDCESEPRPPC 142
D + C + PC + CGND C K +C+G DC D SDE+ C
Sbjct: 423 DEQNCTQSIPCNNRTFKCGNDI------CFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSA 476
Query: 143 RDRVV 147
R++
Sbjct: 477 LHRII 481
>gi|133908621 perforin 1 precursor [Homo sapiens]
Length = 555
Score = 42.4 bits (98), Expect = 0.001
Identities = 42/198 (21%), Positives = 78/198 (39%), Gaps = 14/198 (7%)
Query: 335 YFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEI 394
Y + YGTH+ + LGG + L + +G+ +++ CL V++
Sbjct: 212 YLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHG- 270
Query: 395 SVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTD 454
S+ AE C ++ + + + + S + GG LL G
Sbjct: 271 SISAEAKA--CEEKKKKHKMTASFHQTYRERHSEVVGGHHTSI----NDLLFGIQAGPEQ 324
Query: 455 FVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFS-VRKC-HT 512
+ W +S+ +P L+ L P++ V + + +++ L RA+ Y+ + + R C
Sbjct: 325 YSAWVNSLPGSPGLVDYTLEPLH----VLLDSQDPRREALRRALSQYLTDRARWRDCSRP 380
Query: 513 CQNGGTVILMDGKCLCAC 530
C G D C C C
Sbjct: 381 CPPGRQKSPRD-PCQCVC 397
>gi|40254808 perforin 1 precursor [Homo sapiens]
Length = 555
Score = 42.4 bits (98), Expect = 0.001
Identities = 42/198 (21%), Positives = 78/198 (39%), Gaps = 14/198 (7%)
Query: 335 YFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEI 394
Y + YGTH+ + LGG + L + +G+ +++ CL V++
Sbjct: 212 YLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHG- 270
Query: 395 SVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTD 454
S+ AE C ++ + + + + S + GG LL G
Sbjct: 271 SISAEAKA--CEEKKKKHKMTASFHQTYRERHSEVVGGHHTSI----NDLLFGIQAGPEQ 324
Query: 455 FVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFS-VRKC-HT 512
+ W +S+ +P L+ L P++ V + + +++ L RA+ Y+ + + R C
Sbjct: 325 YSAWVNSLPGSPGLVDYTLEPLH----VLLDSQDPRREALRRALSQYLTDRARWRDCSRP 380
Query: 513 CQNGGTVILMDGKCLCAC 530
C G D C C C
Sbjct: 381 CPPGRQKSPRD-PCQCVC 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,921,277
Number of Sequences: 37866
Number of extensions: 1012796
Number of successful extensions: 3203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 2492
Number of HSP's gapped (non-prelim): 695
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.