Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 42734375
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42734375 ankyrin repeat and sterile alpha motif domain
containing 3 [Homo sapiens]
(656 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42734375 ankyrin repeat and sterile alpha motif domain contai... 1310 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 105 1e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 99 1e-20
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 99 1e-20
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 99 1e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 97 4e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 97 4e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 97 4e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 97 4e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 97 4e-20
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 96 1e-19
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 94 4e-19
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 94 4e-19
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 93 9e-19
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 92 1e-18
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 91 3e-18
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 91 3e-18
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 91 3e-18
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 91 4e-18
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 91 4e-18
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 91 4e-18
gi|118150656 ankyrin repeat domain 7 [Homo sapiens] 90 7e-18
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 90 7e-18
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 89 1e-17
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 89 2e-17
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 86 8e-17
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 86 8e-17
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 85 2e-16
gi|153791352 prostate, ovary, testis expressed protein on chromo... 84 4e-16
gi|134133226 protein expressed in prostate, ovary, testis, and p... 82 1e-15
>gi|42734375 ankyrin repeat and sterile alpha motif domain
containing 3 [Homo sapiens]
Length = 656
Score = 1310 bits (3390), Expect = 0.0
Identities = 656/656 (100%), Positives = 656/656 (100%)
Query: 1 MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRREL 60
MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRREL
Sbjct: 1 MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRREL 60
Query: 61 DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF 120
DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF
Sbjct: 61 DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF 120
Query: 121 LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAG 180
LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAG
Sbjct: 121 LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAG 180
Query: 181 HEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYRSPEKYE 240
HEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYRSPEKYE
Sbjct: 181 HEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYRSPEKYE 240
Query: 241 DLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTF 300
DLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTF
Sbjct: 241 DLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTF 300
Query: 301 NSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARA 360
NSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARA
Sbjct: 301 NSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARA 360
Query: 361 QGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQ 420
QGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQ
Sbjct: 361 QGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQ 420
Query: 421 RAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTS 480
RAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTS
Sbjct: 421 RAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTS 480
Query: 481 AIARWHSSARPPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVE 540
AIARWHSSARPPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVE
Sbjct: 481 AIARWHSSARPPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVE 540
Query: 541 SCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAV 600
SCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAV
Sbjct: 541 SCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAV 600
Query: 601 PPADSKGWQASLQAMSLPELSGALEDRVREMGQALCLVTQSLEKLQVLNGKKWRET 656
PPADSKGWQASLQAMSLPELSGALEDRVREMGQALCLVTQSLEKLQVLNGKKWRET
Sbjct: 601 PPADSKGWQASLQAMSLPELSGALEDRVREMGQALCLVTQSLEKLQVLNGKKWRET 656
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 105 bits (263), Expect = 1e-22
Identities = 73/203 (35%), Positives = 108/203 (53%), Gaps = 9/203 (4%)
Query: 25 GTQVSGEELDVPLDLHTAA-----SIGQYEVVKECVQR-RELDLNKKNGGGWTPLMYASY 78
G +V+ E++D L AA S G VV + R E+D K+G TPL+ A+Y
Sbjct: 700 GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG--MTPLLVAAY 757
Query: 79 IGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTA 138
GH +V LLLE G V+ G+TPL+ A+S G+ S+ LL GA ++ D +G T
Sbjct: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L ++ G+ +VR LLD G + N R+ G+TPL AA GH +I + + G + +
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDD-AGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
D+ G +LA Q GH V ++
Sbjct: 877 DNDGRIPFILASQEGHYDCVQIL 899
Score = 100 bits (250), Expect = 3e-21
Identities = 72/210 (34%), Positives = 104/210 (49%), Gaps = 9/210 (4%)
Query: 17 SLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYA 76
+L + G ++ PL L AA G +VV C+ ++N + GWT L A
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTL--AARQGHTKVVN-CLIGCGANINHTDQDGWTALRSA 618
Query: 77 SYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGW 136
++ GH +V LL AGV V+ + +T L A+ G+E I LLQ GAE+ D +G
Sbjct: 619 AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
Query: 137 TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEA-----AAAGHEIIVQYFLNH 191
TAL GH+ +V LLD GA N E + G T L A A+ GH +V ++
Sbjct: 679 TALIAAAYMGHREIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 192 GVKVDARDHSGATARMLAKQYGHMKIVALM 221
G +VD D G T ++A GH+ +V L+
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Score = 94.4 bits (233), Expect = 3e-19
Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L A++ G EVV+ + R LD N ++ GWTPL A++ GH I L+E G N
Sbjct: 818 LSIASAQGNVEVVRTLLDRG-LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+G+ P +LAS G+ LL+ + ++ + G AL GH+ +V L G
Sbjct: 877 DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N ++ G L A + +YFL +G V+A D G TA ++ GHM++V
Sbjct: 937 ADVNCKD-ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMV 995
Query: 219 ALMDTY 224
++ Y
Sbjct: 996 QVLIAY 1001
Score = 89.7 bits (221), Expect = 7e-18
Identities = 65/219 (29%), Positives = 99/219 (45%), Gaps = 21/219 (9%)
Query: 20 MWHG------LGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELD------------ 61
+W+G L T + E+ + L + A + + C+ R+ L+
Sbjct: 476 IWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNG 535
Query: 62 --LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAY 119
+N+ + G T L A+Y G +V+LL+ G + + G TPL LA+ G+ +
Sbjct: 536 ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 120 FLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAA 179
L+ GA + D GWTAL GH +V LL +G + + T L AA
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD-ADSRTALRAAAWG 654
Query: 180 GHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
GHE IV L HG +V+ D+ G TA + A GH +IV
Sbjct: 655 GHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693
Score = 84.0 bits (206), Expect = 4e-16
Identities = 55/180 (30%), Positives = 90/180 (50%), Gaps = 2/180 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A+ G Y+ V+ ++ + +++++ G L A+ GH IV LL G VN +
Sbjct: 887 ASQEGHYDCVQILLENKS-NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD 945
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G+ L + + ++A + L+ GA +E D +G TAL GH MV+ L+ A+
Sbjct: 946 GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + + L AA GH +VQ + HG VD + GATA +A Q GH+ +V ++
Sbjct: 1006 NAADNE-KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Score = 69.7 bits (169), Expect = 8e-12
Identities = 58/211 (27%), Positives = 91/211 (43%), Gaps = 35/211 (16%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G +V + D L AA G +VV + + D++ + G TPL+ A+ +GH ++
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVV-DLLLEGGADVDHTDNNGRTPLLAAASMGHASV 796
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC-- 142
V+ LL G +V+ EG+T L +AS+ GN + LL +G + +D GWT L
Sbjct: 797 VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF 856
Query: 143 -------------------------------TSAGHQHMVRFLLDSGANANVREPICGFT 171
+ GH V+ LL++ +N + R G
Sbjct: 857 EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR-GYDGRN 915
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSG 202
L AA GH IV+ +HG V+ +D G
Sbjct: 916 ALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 1/137 (0%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V + + LH + G E+V+ + D+N + + L A++ GH +
Sbjct: 969 GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA-DVNAADNEKRSALQSAAWQGHVKV 1027
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LL+E G V+ +G T L +A+ G+ + LL+ GA+ D G TA+
Sbjct: 1028 VQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAK 1087
Query: 145 AGHQHMVRFLLDSGANA 161
GH +++ L GA++
Sbjct: 1088 NGHSQIIKLLEKYGASS 1104
Score = 53.1 bits (126), Expect = 8e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 1/124 (0%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G T L + + GH +V +L+ VN E ++ L A+ G+ + L++ GA +
Sbjct: 979 GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
+ QG TAL GH +V+ LL+ GA+ N + G T + AA GH I++
Sbjct: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF-GRTAMRVAAKNGHSQIIKLL 1097
Query: 189 LNHG 192
+G
Sbjct: 1098 EKYG 1101
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 99.0 bits (245), Expect = 1e-20
Identities = 65/202 (32%), Positives = 100/202 (49%), Gaps = 2/202 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q ++ + + N G TPL AS GH +V LLL+ G ++++
Sbjct: 612 LHIAAKKNQMQIASTLLNYGA-ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 670
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G T L LA+ ++A L + GA+ + G+T L G+ MV FLL G
Sbjct: 671 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG 730
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N + G+TPL +AA GH I+ L HG K +A +G TA +AK+ G++ +V
Sbjct: 731 ANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Query: 219 ALMDTYSPSLPKSLYRSPEKYE 240
+ + + + EK++
Sbjct: 790 DTLKVVTEEVTTTTTTITEKHK 811
Score = 90.9 bits (224), Expect = 3e-18
Identities = 66/181 (36%), Positives = 85/181 (46%), Gaps = 4/181 (2%)
Query: 39 LHTAASIGQYEVVKECVQRREL-DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
LH AA G +V K +QRR D KNG TPL A++ + + LLLE G S +
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNG--LTPLHVAAHYDNQKVALLLLEKGASPHA 603
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDS 157
G TPL +A+ IA LL GAE + QG T L + GH MV LLD
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Query: 158 GANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
GAN ++ G T L AA + HG DA G T ++A YG++K+
Sbjct: 664 GANIHMSTK-SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
Query: 218 V 218
V
Sbjct: 723 V 723
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/183 (32%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +VK + R ++ K G TPL A+ GHD +V LLLE G +
Sbjct: 249 LHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 307
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +PL +A+ + LLQ A ++ + TAL GH + + LLD
Sbjct: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 367
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N R + GFTPL A +++ + +G + A SG T +A GH+ IV
Sbjct: 368 ANPNAR-ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 426
Query: 219 ALM 221
L+
Sbjct: 427 LLL 429
Score = 87.8 bits (216), Expect = 3e-17
Identities = 66/194 (34%), Positives = 98/194 (50%), Gaps = 10/194 (5%)
Query: 34 DVPLD----LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLL 89
DV LD LH AA G Y V K + +R + N + G+TPL A ++ LL+
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGFTPLHIACKKNRIKVMELLV 397
Query: 90 EAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQH 149
+ G S+ T G TP+ +A+ G+ +I LLQ GA ++ +I+G TAL AG
Sbjct: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 457
Query: 150 MVRFLLDSGA--NANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARM 207
+VR LL +GA +A RE TPL A+ G IVQ L H DA +G T
Sbjct: 458 VVRCLLRNGALVDARAREE---QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514
Query: 208 LAKQYGHMKIVALM 221
++ + G + + +++
Sbjct: 515 ISAREGQVDVASVL 528
Score = 83.2 bits (204), Expect = 7e-16
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 1/160 (0%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFL 121
+N+ G+TPL A++ G+ + LLL G +V+ G TPL +AS GN ++ L
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 122 LQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
L +G +++ K G T L +GH +V LL+ GA R G +PL AA H
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDH 323
Query: 182 EIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
V++ L H VD TA +A GH ++ L+
Sbjct: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Score = 80.1 bits (196), Expect = 6e-15
Identities = 58/197 (29%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V + LH A+ +G+ E+V+ +Q + G+TPL ++ G +
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDV 524
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+LLEAG + ++ T +G TPL +A+ G+ +A LLQ+ A + G T L
Sbjct: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
+Q + LL+ GA+ + G+TPL AA I LN+G + + G T
Sbjct: 585 YDNQKVALLLLEKGASPHATAK-NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643
Query: 205 ARMLAKQYGHMKIVALM 221
LA Q GH +V L+
Sbjct: 644 PLHLASQEGHTDMVTLL 660
Score = 75.1 bits (183), Expect = 2e-13
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 2/157 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
AA G + V E + + +D+N N G L A+ GH +V LL G SV+ T +
Sbjct: 17 AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L +AS G + L+++GA + + G+T L+ H +V++LL++GAN
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+ GFTPL A GH V L + K R
Sbjct: 136 STATE-DGFTPLAVALQQGHNQAVAILLENDTKGKVR 171
Score = 73.9 bits (180), Expect = 4e-13
Identities = 60/206 (29%), Positives = 92/206 (44%), Gaps = 12/206 (5%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G G+ V LH A+ GQ EVVK V + ++N ++ G+TPL A+ H
Sbjct: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAAQENHI 122
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLE G + + T +G TPL +A G+ LL+ + +++ AL
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR----LPALHIA 178
Query: 143 TSAGHQHMVRFLLDSGANANVREPI-------CGFTPLMEAAAAGHEIIVQYFLNHGVKV 195
LL + NA+V+ + GFTPL AA G+ + LN G V
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Query: 196 DARDHSGATARMLAKQYGHMKIVALM 221
D +G T +A + G+ +V L+
Sbjct: 239 DFTARNGITPLHVASKRGNTNMVKLL 264
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/183 (30%), Positives = 78/183 (42%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
+H AA +G +V +Q + N G T L A+ G +V LL G V+
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 472
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
E QTPL +AS G I LLQ A + G+T L G + LL++G
Sbjct: 473 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A A+ GFTPL AA G + + L D+ +G T +A Y + K+
Sbjct: 533 A-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 591
Query: 219 ALM 221
L+
Sbjct: 592 LLL 594
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 1/118 (0%)
Query: 101 EGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGAN 160
+ + A+ GN L+ G ++ + G AL GH +V+ LL G++
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 161 ANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G T L A+ AG +V+ + G ++A+ +G T +A Q H+ +V
Sbjct: 69 VDSATK-KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Score = 31.2 bits (69), Expect = 3.2
Identities = 18/53 (33%), Positives = 25/53 (47%)
Query: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G L AA GH +VQ L G VD+ G TA +A G ++V ++
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 99.0 bits (245), Expect = 1e-20
Identities = 65/202 (32%), Positives = 100/202 (49%), Gaps = 2/202 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q ++ + + N G TPL AS GH +V LLL+ G ++++
Sbjct: 633 LHIAAKKNQMQIASTLLNYGA-ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G T L LA+ ++A L + GA+ + G+T L G+ MV FLL G
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG 751
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N + G+TPL +AA GH I+ L HG K +A +G TA +AK+ G++ +V
Sbjct: 752 ANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 219 ALMDTYSPSLPKSLYRSPEKYE 240
+ + + + EK++
Sbjct: 811 DTLKVVTEEVTTTTTTITEKHK 832
Score = 90.9 bits (224), Expect = 3e-18
Identities = 66/181 (36%), Positives = 85/181 (46%), Gaps = 4/181 (2%)
Query: 39 LHTAASIGQYEVVKECVQRREL-DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
LH AA G +V K +QRR D KNG TPL A++ + + LLLE G S +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNG--LTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDS 157
G TPL +A+ IA LL GAE + QG T L + GH MV LLD
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 158 GANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
GAN ++ G T L AA + HG DA G T ++A YG++K+
Sbjct: 685 GANIHMSTK-SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 218 V 218
V
Sbjct: 744 V 744
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/183 (32%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +VK + R ++ K G TPL A+ GHD +V LLLE G +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +PL +A+ + LLQ A ++ + TAL GH + + LLD
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N R + GFTPL A +++ + +G + A SG T +A GH+ IV
Sbjct: 389 ANPNAR-ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
Query: 219 ALM 221
L+
Sbjct: 448 LLL 450
Score = 87.8 bits (216), Expect = 3e-17
Identities = 66/194 (34%), Positives = 98/194 (50%), Gaps = 10/194 (5%)
Query: 34 DVPLD----LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLL 89
DV LD LH AA G Y V K + +R + N + G+TPL A ++ LL+
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGFTPLHIACKKNRIKVMELLV 418
Query: 90 EAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQH 149
+ G S+ T G TP+ +A+ G+ +I LLQ GA ++ +I+G TAL AG
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 150 MVRFLLDSGA--NANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARM 207
+VR LL +GA +A RE TPL A+ G IVQ L H DA +G T
Sbjct: 479 VVRCLLRNGALVDARAREE---QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Query: 208 LAKQYGHMKIVALM 221
++ + G + + +++
Sbjct: 536 ISAREGQVDVASVL 549
Score = 83.2 bits (204), Expect = 7e-16
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 1/160 (0%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFL 121
+N+ G+TPL A++ G+ + LLL G +V+ G TPL +AS GN ++ L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 122 LQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
L +G +++ K G T L +GH +V LL+ GA R G +PL AA H
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDH 344
Query: 182 EIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
V++ L H VD TA +A GH ++ L+
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 80.1 bits (196), Expect = 6e-15
Identities = 58/197 (29%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V + LH A+ +G+ E+V+ +Q + G+TPL ++ G +
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDV 545
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+LLEAG + ++ T +G TPL +A+ G+ +A LLQ+ A + G T L
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
+Q + LL+ GA+ + G+TPL AA I LN+G + + G T
Sbjct: 606 YDNQKVALLLLEKGASPHATAK-NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 205 ARMLAKQYGHMKIVALM 221
LA Q GH +V L+
Sbjct: 665 PLHLASQEGHTDMVTLL 681
Score = 75.1 bits (183), Expect = 2e-13
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 2/157 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
AA G + V E + + +D+N N G L A+ GH +V LL G SV+ T +
Sbjct: 38 AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L +AS G + L+++GA + + G+T L+ H +V++LL++GAN
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+ GFTPL A GH V L + K R
Sbjct: 157 STATE-DGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Score = 73.9 bits (180), Expect = 4e-13
Identities = 60/206 (29%), Positives = 92/206 (44%), Gaps = 12/206 (5%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G G+ V LH A+ GQ EVVK V + ++N ++ G+TPL A+ H
Sbjct: 85 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAAQENHI 143
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLE G + + T +G TPL +A G+ LL+ + +++ AL
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR----LPALHIA 199
Query: 143 TSAGHQHMVRFLLDSGANANVREPI-------CGFTPLMEAAAAGHEIIVQYFLNHGVKV 195
LL + NA+V+ + GFTPL AA G+ + LN G V
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 196 DARDHSGATARMLAKQYGHMKIVALM 221
D +G T +A + G+ +V L+
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLL 285
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/183 (30%), Positives = 78/183 (42%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
+H AA +G +V +Q + N G T L A+ G +V LL G V+
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
E QTPL +AS G I LLQ A + G+T L G + LL++G
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A A+ GFTPL AA G + + L D+ +G T +A Y + K+
Sbjct: 554 A-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 219 ALM 221
L+
Sbjct: 613 LLL 615
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 1/118 (0%)
Query: 101 EGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGAN 160
+ + A+ GN L+ G ++ + G AL GH +V+ LL G++
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 161 ANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G T L A+ AG +V+ + G ++A+ +G T +A Q H+ +V
Sbjct: 90 VDSATK-KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Score = 31.2 bits (69), Expect = 3.2
Identities = 18/53 (33%), Positives = 25/53 (47%)
Query: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G L AA GH +VQ L G VD+ G TA +A G ++V ++
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 99.0 bits (245), Expect = 1e-20
Identities = 65/202 (32%), Positives = 100/202 (49%), Gaps = 2/202 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q ++ + + N G TPL AS GH +V LLL+ G ++++
Sbjct: 633 LHIAAKKNQMQIASTLLNYGA-ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G T L LA+ ++A L + GA+ + G+T L G+ MV FLL G
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG 751
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N + G+TPL +AA GH I+ L HG K +A +G TA +AK+ G++ +V
Sbjct: 752 ANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 219 ALMDTYSPSLPKSLYRSPEKYE 240
+ + + + EK++
Sbjct: 811 DTLKVVTEEVTTTTTTITEKHK 832
Score = 90.9 bits (224), Expect = 3e-18
Identities = 66/181 (36%), Positives = 85/181 (46%), Gaps = 4/181 (2%)
Query: 39 LHTAASIGQYEVVKECVQRREL-DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
LH AA G +V K +QRR D KNG TPL A++ + + LLLE G S +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNG--LTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDS 157
G TPL +A+ IA LL GAE + QG T L + GH MV LLD
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 158 GANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
GAN ++ G T L AA + HG DA G T ++A YG++K+
Sbjct: 685 GANIHMSTK-SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 218 V 218
V
Sbjct: 744 V 744
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/183 (32%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +VK + R ++ K G TPL A+ GHD +V LLLE G +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +PL +A+ + LLQ A ++ + TAL GH + + LLD
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N R + GFTPL A +++ + +G + A SG T +A GH+ IV
Sbjct: 389 ANPNAR-ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
Query: 219 ALM 221
L+
Sbjct: 448 LLL 450
Score = 87.8 bits (216), Expect = 3e-17
Identities = 66/194 (34%), Positives = 98/194 (50%), Gaps = 10/194 (5%)
Query: 34 DVPLD----LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLL 89
DV LD LH AA G Y V K + +R + N + G+TPL A ++ LL+
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRA-NPNARALNGFTPLHIACKKNRIKVMELLV 418
Query: 90 EAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQH 149
+ G S+ T G TP+ +A+ G+ +I LLQ GA ++ +I+G TAL AG
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 150 MVRFLLDSGA--NANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARM 207
+VR LL +GA +A RE TPL A+ G IVQ L H DA +G T
Sbjct: 479 VVRCLLRNGALVDARAREE---QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Query: 208 LAKQYGHMKIVALM 221
++ + G + + +++
Sbjct: 536 ISAREGQVDVASVL 549
Score = 83.2 bits (204), Expect = 7e-16
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 1/160 (0%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFL 121
+N+ G+TPL A++ G+ + LLL G +V+ G TPL +AS GN ++ L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 122 LQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
L +G +++ K G T L +GH +V LL+ GA R G +PL AA H
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDH 344
Query: 182 EIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
V++ L H VD TA +A GH ++ L+
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 80.1 bits (196), Expect = 6e-15
Identities = 58/197 (29%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V + LH A+ +G+ E+V+ +Q + G+TPL ++ G +
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDV 545
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+LLEAG + ++ T +G TPL +A+ G+ +A LLQ+ A + G T L
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
+Q + LL+ GA+ + G+TPL AA I LN+G + + G T
Sbjct: 606 YDNQKVALLLLEKGASPHATAK-NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 205 ARMLAKQYGHMKIVALM 221
LA Q GH +V L+
Sbjct: 665 PLHLASQEGHTDMVTLL 681
Score = 75.1 bits (183), Expect = 2e-13
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 2/157 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
AA G + V E + + +D+N N G L A+ GH +V LL G SV+ T +
Sbjct: 38 AARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L +AS G + L+++GA + + G+T L+ H +V++LL++GAN
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+ GFTPL A GH V L + K R
Sbjct: 157 STATE-DGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Score = 73.9 bits (180), Expect = 4e-13
Identities = 60/206 (29%), Positives = 92/206 (44%), Gaps = 12/206 (5%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G G+ V LH A+ GQ EVVK V + ++N ++ G+TPL A+ H
Sbjct: 85 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAAQENHI 143
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLE G + + T +G TPL +A G+ LL+ + +++ AL
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR----LPALHIA 199
Query: 143 TSAGHQHMVRFLLDSGANANVREPI-------CGFTPLMEAAAAGHEIIVQYFLNHGVKV 195
LL + NA+V+ + GFTPL AA G+ + LN G V
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 196 DARDHSGATARMLAKQYGHMKIVALM 221
D +G T +A + G+ +V L+
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLL 285
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/183 (30%), Positives = 78/183 (42%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
+H AA +G +V +Q + N G T L A+ G +V LL G V+
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
E QTPL +AS G I LLQ A + G+T L G + LL++G
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A A+ GFTPL AA G + + L D+ +G T +A Y + K+
Sbjct: 554 A-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 219 ALM 221
L+
Sbjct: 613 LLL 615
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 1/118 (0%)
Query: 101 EGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGAN 160
+ + A+ GN L+ G ++ + G AL GH +V+ LL G++
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 161 ANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G T L A+ AG +V+ + G ++A+ +G T +A Q H+ +V
Sbjct: 90 VDSATK-KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Score = 31.2 bits (69), Expect = 3.2
Identities = 18/53 (33%), Positives = 25/53 (47%)
Query: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G L AA GH +VQ L G VD+ G TA +A G ++V ++
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/183 (35%), Positives = 84/183 (45%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA G+ V E + R+ N G TPL A + + IV LLL G S + P
Sbjct: 573 LHVAAKYGKVRVA-ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL +A+ +A LLQ G + +QG T L GH MV LL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N+ G TPL A GH + + HGV VDA G T +A YG++K+V
Sbjct: 692 ANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 750
Query: 219 ALM 221
+
Sbjct: 751 KFL 753
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/197 (30%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + + L+ LH A V+ E + + ++ G TPL AS++GH I
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LL+ G S NV + +TPL +A+ G+ +A +LLQ A++ K T L
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH +MV+ LL++ AN N+ G TPL AA GH V L G T
Sbjct: 513 IGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 571
Query: 205 ARMLAKQYGHMKIVALM 221
+A +YG +++ L+
Sbjct: 572 PLHVAAKYGKVRVAELL 588
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/183 (30%), Positives = 91/183 (49%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q EV + +Q N ++ G TPL A+ GH +V LLL + N+
Sbjct: 639 LHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL L + G+ +A L++ G ++ G+T L + G+ +V+FLL
Sbjct: 698 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N + + G++PL +AA GH IV L +G + G T +AK+ G++ +
Sbjct: 758 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 816
Query: 219 ALM 221
++
Sbjct: 817 DVL 819
Score = 83.2 bits (204), Expect = 7e-16
Identities = 49/142 (34%), Positives = 73/142 (51%), Gaps = 1/142 (0%)
Query: 57 RRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNES 116
R +D+N N G L AS GH +V LL + + T +G T L +A+ G +
Sbjct: 66 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 125
Query: 117 IAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEA 176
+ L+ GA + + +G+T L+ H +V+FLL++GAN NV GFTPL A
Sbjct: 126 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE-DGFTPLAVA 184
Query: 177 AAAGHEIIVQYFLNHGVKVDAR 198
GHE +V + +N+G K R
Sbjct: 185 LQQGHENVVAHLINYGTKGKVR 206
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +V+ + R + K TPL A+ GH I +LL+ G +
Sbjct: 276 LHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 334
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +P+ +A+ + LLQ AE++ + T L GH + + LLD G
Sbjct: 335 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 394
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N R + GFTPL A H +++ L G +DA SG T +A GH+ IV
Sbjct: 395 AKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
TPL A++ GH + +LL+ G N G TPL +A + + LL+ GA ++
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
G T L + GH +V+ LL GA+ NV + TPL AA AGH + +Y L
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQ 491
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM--DTYSPSLPKSLYRSP 236
+ KV+A+ T A + GH +V L+ + +P+L + +P
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 539
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 29/211 (13%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G ++V E + + E+ L G T L A+ G D +V L+ G +VN
Sbjct: 82 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 140
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+ +G TPL +A+ + + FLL+ GA + G+T L GH+++V L++ G
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 159 ANANVREPI----------------------------CGFTPLMEAAAAGHEIIVQYFLN 190
VR P GFTPL AA + + Q LN
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G V+ +G T +A + G++ +V L+
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
Score = 75.5 bits (184), Expect = 1e-13
Identities = 66/231 (28%), Positives = 95/231 (41%), Gaps = 35/231 (15%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G VS +++ PL H AA G EV K +Q + +N K TPL A+ IGH
Sbjct: 460 GASPNVSNVKVETPL--HMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHT 516
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLLE + N+ T G TPL +A+ G+ LL++ A +G+T L
Sbjct: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Query: 143 TSAGHQHMVRFLLDSGANANVR-----EPI---------------------------CGF 170
G + LL+ A+ N P+ G+
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
Query: 171 TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPL AA + + L +G +A G T LA Q GH ++VAL+
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Score = 74.3 bits (181), Expect = 3e-13
Identities = 52/157 (33%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + E + LH AA G E+V + + + + N N G TPL + GH +
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPV 716
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+L++ GV V+ T G TPL +AS GN + FLLQ A++ K G++ L
Sbjct: 717 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 776
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
GH +V LL +GA+ N G TPL A G+
Sbjct: 777 QGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGY 812
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/233 (27%), Positives = 95/233 (40%), Gaps = 31/233 (13%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V+ + L+ AA EVVK ++ + N G+TPL A GH+ +
Sbjct: 134 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQNVATEDGFTPLAVALQQGHENV 192
Query: 85 VHLLLEAGVSVNV------------------------PTPE-----GQTPLMLASSCGNE 115
V L+ G V P P+ G TPL +A+ N
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 252
Query: 116 SIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLME 175
++A LL +GA + G T L + G+ MVR LLD GA + TPL
Sbjct: 253 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHC 311
Query: 176 AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
AA GH I + L+HG + A+ +G + +A Q H+ V L+ Y +
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 364
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/185 (30%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRR--ELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN 96
LH AA G E V +++ + + KK G+TPL A+ G + LLLE N
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHPN 596
Query: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD 156
G TPL +A N I LL +G G+T L + R LL
Sbjct: 597 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656
Query: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
G +AN E + G TPL AA GH +V L+ + + SG T L Q GH+
Sbjct: 657 YGGSANA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 217 IVALM 221
+ ++
Sbjct: 716 VADVL 720
Score = 69.7 bits (169), Expect = 8e-12
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 1/153 (0%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G+TPL A++ + + LLL G SVN G TPL +AS GN + LL +GA++
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
E K T L GH + LLD GA + G +P+ AA H V+
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLL 357
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
L + ++D T +A GH ++ ++
Sbjct: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 390
Score = 68.2 bits (165), Expect = 2e-11
Identities = 47/136 (34%), Positives = 64/136 (47%), Gaps = 1/136 (0%)
Query: 89 LEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQ 148
L GV +N G L LAS G+ + LL + LE +G TAL AG
Sbjct: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124
Query: 149 HMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARML 208
+VR L++ GAN N + GFTPL AA H +V++ L +G + G T +
Sbjct: 125 EVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 183
Query: 209 AKQYGHMKIVALMDTY 224
A Q GH +VA + Y
Sbjct: 184 ALQQGHENVVAHLINY 199
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 1/121 (0%)
Query: 101 EGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGAN 160
+ T + A+ GN A L+ G ++ + G L + GH MV LL
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103
Query: 161 ANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVAL 220
G T L AA AG + +V+ +N+G V+A+ G T +A Q H+++V
Sbjct: 104 LETTTK-KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 221 M 221
+
Sbjct: 163 L 163
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/183 (35%), Positives = 84/183 (45%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA G+ V E + R+ N G TPL A + + IV LLL G S + P
Sbjct: 540 LHVAAKYGKVRVA-ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL +A+ +A LLQ G + +QG T L GH MV LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N+ G TPL A GH + + HGV VDA G T +A YG++K+V
Sbjct: 659 ANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 219 ALM 221
+
Sbjct: 718 KFL 720
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/197 (30%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + + L+ LH A V+ E + + ++ G TPL AS++GH I
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LL+ G S NV + +TPL +A+ G+ +A +LLQ A++ K T L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH +MV+ LL++ AN N+ G TPL AA GH V L G T
Sbjct: 480 IGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 205 ARMLAKQYGHMKIVALM 221
+A +YG +++ L+
Sbjct: 539 PLHVAAKYGKVRVAELL 555
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/183 (30%), Positives = 91/183 (49%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q EV + +Q N ++ G TPL A+ GH +V LLL + N+
Sbjct: 606 LHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL L + G+ +A L++ G ++ G+T L + G+ +V+FLL
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N + + G++PL +AA GH IV L +G + G T +AK+ G++ +
Sbjct: 725 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 219 ALM 221
++
Sbjct: 784 DVL 786
Score = 83.6 bits (205), Expect = 5e-16
Identities = 55/171 (32%), Positives = 82/171 (47%), Gaps = 2/171 (1%)
Query: 28 VSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHL 87
V E D AA G + + + R +D+N N G L AS GH +V
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 88 LLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGH 147
LL + + T +G T L +A+ G + + L+ GA + + +G+T L+ H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 148 QHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+V+FLL++GAN NV GFTPL A GHE +V + +N+G K R
Sbjct: 124 LEVVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +V+ + R + K TPL A+ GH I +LL+ G +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +P+ +A+ + LLQ AE++ + T L GH + + LLD G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N R + GFTPL A H +++ L G +DA SG T +A GH+ IV
Sbjct: 362 AKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
TPL A++ GH + +LL+ G N G TPL +A + + LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
G T L + GH +V+ LL GA+ NV + TPL AA AGH + +Y L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQ 458
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM--DTYSPSLPKSLYRSP 236
+ KV+A+ T A + GH +V L+ + +P+L + +P
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 29/211 (13%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G ++V E + + E+ L G T L A+ G D +V L+ G +VN
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+ +G TPL +A+ + + FLL+ GA + G+T L GH+++V L++ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 159 ANANVREPI----------------------------CGFTPLMEAAAAGHEIIVQYFLN 190
VR P GFTPL AA + + Q LN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G V+ +G T +A + G++ +V L+
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 75.5 bits (184), Expect = 1e-13
Identities = 66/231 (28%), Positives = 95/231 (41%), Gaps = 35/231 (15%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G VS +++ PL H AA G EV K +Q + +N K TPL A+ IGH
Sbjct: 427 GASPNVSNVKVETPL--HMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHT 483
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLLE + N+ T G TPL +A+ G+ LL++ A +G+T L
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 143 TSAGHQHMVRFLLDSGANANVR-----EPI---------------------------CGF 170
G + LL+ A+ N P+ G+
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 171 TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPL AA + + L +G +A G T LA Q GH ++VAL+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 74.3 bits (181), Expect = 3e-13
Identities = 52/157 (33%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + E + LH AA G E+V + + + + N N G TPL + GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPV 683
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+L++ GV V+ T G TPL +AS GN + FLLQ A++ K G++ L
Sbjct: 684 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
GH +V LL +GA+ N G TPL A G+
Sbjct: 744 QGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/233 (27%), Positives = 95/233 (40%), Gaps = 31/233 (13%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V+ + L+ AA EVVK ++ + N G+TPL A GH+ +
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQNVATEDGFTPLAVALQQGHENV 159
Query: 85 VHLLLEAGVSVNV------------------------PTPE-----GQTPLMLASSCGNE 115
V L+ G V P P+ G TPL +A+ N
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 116 SIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLME 175
++A LL +GA + G T L + G+ MVR LLD GA + TPL
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHC 278
Query: 176 AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
AA GH I + L+HG + A+ +G + +A Q H+ V L+ Y +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/185 (30%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRR--ELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN 96
LH AA G E V +++ + + KK G+TPL A+ G + LLLE N
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD 156
G TPL +A N I LL +G G+T L + R LL
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
G +AN E + G TPL AA GH +V L+ + + SG T L Q GH+
Sbjct: 624 YGGSANA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 217 IVALM 221
+ ++
Sbjct: 683 VADVL 687
Score = 69.7 bits (169), Expect = 8e-12
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 1/153 (0%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G+TPL A++ + + LLL G SVN G TPL +AS GN + LL +GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
E K T L GH + LLD GA + G +P+ AA H V+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLL 324
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
L + ++D T +A GH ++ ++
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/128 (27%), Positives = 55/128 (42%), Gaps = 1/128 (0%)
Query: 94 SVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
SV + T + A+ GN A L+ G ++ + G L + GH MV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL G T L AA AG + +V+ +N+G V+A+ G T +A Q
Sbjct: 64 LLHKEIILETTTK-KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 214 HMKIVALM 221
H+++V +
Sbjct: 123 HLEVVKFL 130
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/183 (35%), Positives = 84/183 (45%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA G+ V E + R+ N G TPL A + + IV LLL G S + P
Sbjct: 540 LHVAAKYGKVRVA-ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL +A+ +A LLQ G + +QG T L GH MV LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N+ G TPL A GH + + HGV VDA G T +A YG++K+V
Sbjct: 659 ANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 219 ALM 221
+
Sbjct: 718 KFL 720
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/197 (30%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + + L+ LH A V+ E + + ++ G TPL AS++GH I
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LL+ G S NV + +TPL +A+ G+ +A +LLQ A++ K T L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH +MV+ LL++ AN N+ G TPL AA GH V L G T
Sbjct: 480 IGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 205 ARMLAKQYGHMKIVALM 221
+A +YG +++ L+
Sbjct: 539 PLHVAAKYGKVRVAELL 555
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/183 (30%), Positives = 91/183 (49%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q EV + +Q N ++ G TPL A+ GH +V LLL + N+
Sbjct: 606 LHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL L + G+ +A L++ G ++ G+T L + G+ +V+FLL
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N + + G++PL +AA GH IV L +G + G T +AK+ G++ +
Sbjct: 725 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 219 ALM 221
++
Sbjct: 784 DVL 786
Score = 83.6 bits (205), Expect = 5e-16
Identities = 55/171 (32%), Positives = 82/171 (47%), Gaps = 2/171 (1%)
Query: 28 VSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHL 87
V E D AA G + + + R +D+N N G L AS GH +V
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 88 LLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGH 147
LL + + T +G T L +A+ G + + L+ GA + + +G+T L+ H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 148 QHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+V+FLL++GAN NV GFTPL A GHE +V + +N+G K R
Sbjct: 124 LEVVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +V+ + R + K TPL A+ GH I +LL+ G +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +P+ +A+ + LLQ AE++ + T L GH + + LLD G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N R + GFTPL A H +++ L G +DA SG T +A GH+ IV
Sbjct: 362 AKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
TPL A++ GH + +LL+ G N G TPL +A + + LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
G T L + GH +V+ LL GA+ NV + TPL AA AGH + +Y L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQ 458
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM--DTYSPSLPKSLYRSP 236
+ KV+A+ T A + GH +V L+ + +P+L + +P
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 29/211 (13%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G ++V E + + E+ L G T L A+ G D +V L+ G +VN
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+ +G TPL +A+ + + FLL+ GA + G+T L GH+++V L++ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 159 ANANVREPI----------------------------CGFTPLMEAAAAGHEIIVQYFLN 190
VR P GFTPL AA + + Q LN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G V+ +G T +A + G++ +V L+
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 75.5 bits (184), Expect = 1e-13
Identities = 66/231 (28%), Positives = 95/231 (41%), Gaps = 35/231 (15%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G VS +++ PL H AA G EV K +Q + +N K TPL A+ IGH
Sbjct: 427 GASPNVSNVKVETPL--HMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHT 483
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLLE + N+ T G TPL +A+ G+ LL++ A +G+T L
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 143 TSAGHQHMVRFLLDSGANANVR-----EPI---------------------------CGF 170
G + LL+ A+ N P+ G+
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 171 TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPL AA + + L +G +A G T LA Q GH ++VAL+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 74.3 bits (181), Expect = 3e-13
Identities = 52/157 (33%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + E + LH AA G E+V + + + + N N G TPL + GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPV 683
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+L++ GV V+ T G TPL +AS GN + FLLQ A++ K G++ L
Sbjct: 684 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
GH +V LL +GA+ N G TPL A G+
Sbjct: 744 QGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/233 (27%), Positives = 95/233 (40%), Gaps = 31/233 (13%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V+ + L+ AA EVVK ++ + N G+TPL A GH+ +
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQNVATEDGFTPLAVALQQGHENV 159
Query: 85 VHLLLEAGVSVNV------------------------PTPE-----GQTPLMLASSCGNE 115
V L+ G V P P+ G TPL +A+ N
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 116 SIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLME 175
++A LL +GA + G T L + G+ MVR LLD GA + TPL
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHC 278
Query: 176 AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
AA GH I + L+HG + A+ +G + +A Q H+ V L+ Y +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/185 (30%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRR--ELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN 96
LH AA G E V +++ + + KK G+TPL A+ G + LLLE N
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD 156
G TPL +A N I LL +G G+T L + R LL
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
G +AN E + G TPL AA GH +V L+ + + SG T L Q GH+
Sbjct: 624 YGGSANA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 217 IVALM 221
+ ++
Sbjct: 683 VADVL 687
Score = 69.7 bits (169), Expect = 8e-12
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 1/153 (0%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G+TPL A++ + + LLL G SVN G TPL +AS GN + LL +GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
E K T L GH + LLD GA + G +P+ AA H V+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLL 324
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
L + ++D T +A GH ++ ++
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/128 (27%), Positives = 55/128 (42%), Gaps = 1/128 (0%)
Query: 94 SVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
SV + T + A+ GN A L+ G ++ + G L + GH MV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL G T L AA AG + +V+ +N+G V+A+ G T +A Q
Sbjct: 64 LLHKEIILETTTK-KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 214 HMKIVALM 221
H+++V +
Sbjct: 123 HLEVVKFL 130
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/183 (35%), Positives = 84/183 (45%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA G+ V E + R+ N G TPL A + + IV LLL G S + P
Sbjct: 540 LHVAAKYGKVRVA-ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL +A+ +A LLQ G + +QG T L GH MV LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N+ G TPL A GH + + HGV VDA G T +A YG++K+V
Sbjct: 659 ANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 219 ALM 221
+
Sbjct: 718 KFL 720
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/197 (30%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + + L+ LH A V+ E + + ++ G TPL AS++GH I
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LL+ G S NV + +TPL +A+ G+ +A +LLQ A++ K T L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH +MV+ LL++ AN N+ G TPL AA GH V L G T
Sbjct: 480 IGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 205 ARMLAKQYGHMKIVALM 221
+A +YG +++ L+
Sbjct: 539 PLHVAAKYGKVRVAELL 555
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/183 (30%), Positives = 91/183 (49%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q EV + +Q N ++ G TPL A+ GH +V LLL + N+
Sbjct: 606 LHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL L + G+ +A L++ G ++ G+T L + G+ +V+FLL
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N + + G++PL +AA GH IV L +G + G T +AK+ G++ +
Sbjct: 725 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 219 ALM 221
++
Sbjct: 784 DVL 786
Score = 83.6 bits (205), Expect = 5e-16
Identities = 55/171 (32%), Positives = 82/171 (47%), Gaps = 2/171 (1%)
Query: 28 VSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHL 87
V E D AA G + + + R +D+N N G L AS GH +V
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 88 LLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGH 147
LL + + T +G T L +A+ G + + L+ GA + + +G+T L+ H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 148 QHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+V+FLL++GAN NV GFTPL A GHE +V + +N+G K R
Sbjct: 124 LEVVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +V+ + R + K TPL A+ GH I +LL+ G +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +P+ +A+ + LLQ AE++ + T L GH + + LLD G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N R + GFTPL A H +++ L G +DA SG T +A GH+ IV
Sbjct: 362 AKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
TPL A++ GH + +LL+ G N G TPL +A + + LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
G T L + GH +V+ LL GA+ NV + TPL AA AGH + +Y L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQ 458
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM--DTYSPSLPKSLYRSP 236
+ KV+A+ T A + GH +V L+ + +P+L + +P
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 29/211 (13%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G ++V E + + E+ L G T L A+ G D +V L+ G +VN
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+ +G TPL +A+ + + FLL+ GA + G+T L GH+++V L++ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 159 ANANVREPI----------------------------CGFTPLMEAAAAGHEIIVQYFLN 190
VR P GFTPL AA + + Q LN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G V+ +G T +A + G++ +V L+
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 75.5 bits (184), Expect = 1e-13
Identities = 66/231 (28%), Positives = 95/231 (41%), Gaps = 35/231 (15%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G VS +++ PL H AA G EV K +Q + +N K TPL A+ IGH
Sbjct: 427 GASPNVSNVKVETPL--HMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHT 483
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLLE + N+ T G TPL +A+ G+ LL++ A +G+T L
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 143 TSAGHQHMVRFLLDSGANANVR-----EPI---------------------------CGF 170
G + LL+ A+ N P+ G+
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 171 TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPL AA + + L +G +A G T LA Q GH ++VAL+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 74.3 bits (181), Expect = 3e-13
Identities = 52/157 (33%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + E + LH AA G E+V + + + + N N G TPL + GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPV 683
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+L++ GV V+ T G TPL +AS GN + FLLQ A++ K G++ L
Sbjct: 684 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
GH +V LL +GA+ N G TPL A G+
Sbjct: 744 QGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/233 (27%), Positives = 95/233 (40%), Gaps = 31/233 (13%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V+ + L+ AA EVVK ++ + N G+TPL A GH+ +
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQNVATEDGFTPLAVALQQGHENV 159
Query: 85 VHLLLEAGVSVNV------------------------PTPE-----GQTPLMLASSCGNE 115
V L+ G V P P+ G TPL +A+ N
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 116 SIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLME 175
++A LL +GA + G T L + G+ MVR LLD GA + TPL
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHC 278
Query: 176 AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
AA GH I + L+HG + A+ +G + +A Q H+ V L+ Y +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/185 (30%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRR--ELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN 96
LH AA G E V +++ + + KK G+TPL A+ G + LLLE N
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD 156
G TPL +A N I LL +G G+T L + R LL
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
G +AN E + G TPL AA GH +V L+ + + SG T L Q GH+
Sbjct: 624 YGGSANA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 217 IVALM 221
+ ++
Sbjct: 683 VADVL 687
Score = 69.7 bits (169), Expect = 8e-12
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 1/153 (0%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G+TPL A++ + + LLL G SVN G TPL +AS GN + LL +GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
E K T L GH + LLD GA + G +P+ AA H V+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLL 324
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
L + ++D T +A GH ++ ++
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/128 (27%), Positives = 55/128 (42%), Gaps = 1/128 (0%)
Query: 94 SVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
SV + T + A+ GN A L+ G ++ + G L + GH MV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL G T L AA AG + +V+ +N+G V+A+ G T +A Q
Sbjct: 64 LLHKEIILETTTK-KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 214 HMKIVALM 221
H+++V +
Sbjct: 123 HLEVVKFL 130
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/183 (35%), Positives = 84/183 (45%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA G+ V E + R+ N G TPL A + + IV LLL G S + P
Sbjct: 540 LHVAAKYGKVRVA-ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL +A+ +A LLQ G + +QG T L GH MV LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N+ G TPL A GH + + HGV VDA G T +A YG++K+V
Sbjct: 659 ANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 219 ALM 221
+
Sbjct: 718 KFL 720
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/197 (30%), Positives = 92/197 (46%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + + L+ LH A V+ E + + ++ G TPL AS++GH I
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LL+ G S NV + +TPL +A+ G+ +A +LLQ A++ K T L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH +MV+ LL++ AN N+ G TPL AA GH V L G T
Sbjct: 480 IGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 205 ARMLAKQYGHMKIVALM 221
+A +YG +++ L+
Sbjct: 539 PLHVAAKYGKVRVAELL 555
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/183 (30%), Positives = 91/183 (49%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q EV + +Q N ++ G TPL A+ GH +V LLL + N+
Sbjct: 606 LHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL L + G+ +A L++ G ++ G+T L + G+ +V+FLL
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N + + G++PL +AA GH IV L +G + G T +AK+ G++ +
Sbjct: 725 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 219 ALM 221
++
Sbjct: 784 DVL 786
Score = 83.6 bits (205), Expect = 5e-16
Identities = 55/171 (32%), Positives = 82/171 (47%), Gaps = 2/171 (1%)
Query: 28 VSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHL 87
V E D AA G + + + R +D+N N G L AS GH +V
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 88 LLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGH 147
LL + + T +G T L +A+ G + + L+ GA + + +G+T L+ H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 148 QHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
+V+FLL++GAN NV GFTPL A GHE +V + +N+G K R
Sbjct: 124 LEVVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +V+ + R + K TPL A+ GH I +LL+ G +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +P+ +A+ + LLQ AE++ + T L GH + + LLD G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N R + GFTPL A H +++ L G +DA SG T +A GH+ IV
Sbjct: 362 AKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 3/168 (1%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
TPL A++ GH + +LL+ G N G TPL +A + + LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
G T L + GH +V+ LL GA+ NV + TPL AA AGH + +Y L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQ 458
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM--DTYSPSLPKSLYRSP 236
+ KV+A+ T A + GH +V L+ + +P+L + +P
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 29/211 (13%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G ++V E + + E+ L G T L A+ G D +V L+ G +VN
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+ +G TPL +A+ + + FLL+ GA + G+T L GH+++V L++ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 159 ANANVREPI----------------------------CGFTPLMEAAAAGHEIIVQYFLN 190
VR P GFTPL AA + + Q LN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G V+ +G T +A + G++ +V L+
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 75.5 bits (184), Expect = 1e-13
Identities = 66/231 (28%), Positives = 95/231 (41%), Gaps = 35/231 (15%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G VS +++ PL H AA G EV K +Q + +N K TPL A+ IGH
Sbjct: 427 GASPNVSNVKVETPL--HMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHT 483
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+V LLLE + N+ T G TPL +A+ G+ LL++ A +G+T L
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 143 TSAGHQHMVRFLLDSGANANVR-----EPI---------------------------CGF 170
G + LL+ A+ N P+ G+
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 171 TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPL AA + + L +G +A G T LA Q GH ++VAL+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 74.3 bits (181), Expect = 3e-13
Identities = 52/157 (33%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + E + LH AA G E+V + + + + N N G TPL + GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPV 683
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+L++ GV V+ T G TPL +AS GN + FLLQ A++ K G++ L
Sbjct: 684 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGH 181
GH +V LL +GA+ N G TPL A G+
Sbjct: 744 QGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/233 (27%), Positives = 95/233 (40%), Gaps = 31/233 (13%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V+ + L+ AA EVVK ++ + N G+TPL A GH+ +
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQNVATEDGFTPLAVALQQGHENV 159
Query: 85 VHLLLEAGVSVNV------------------------PTPE-----GQTPLMLASSCGNE 115
V L+ G V P P+ G TPL +A+ N
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 116 SIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLME 175
++A LL +GA + G T L + G+ MVR LLD GA + TPL
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHC 278
Query: 176 AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
AA GH I + L+HG + A+ +G + +A Q H+ V L+ Y +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/185 (30%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRR--ELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN 96
LH AA G E V +++ + + KK G+TPL A+ G + LLLE N
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD 156
G TPL +A N I LL +G G+T L + R LL
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
G +AN E + G TPL AA GH +V L+ + + SG T L Q GH+
Sbjct: 624 YGGSANA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 217 IVALM 221
+ ++
Sbjct: 683 VADVL 687
Score = 69.7 bits (169), Expect = 8e-12
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 1/153 (0%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G+TPL A++ + + LLL G SVN G TPL +AS GN + LL +GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
E K T L GH + LLD GA + G +P+ AA H V+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLL 324
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
L + ++D T +A GH ++ ++
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/128 (27%), Positives = 55/128 (42%), Gaps = 1/128 (0%)
Query: 94 SVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
SV + T + A+ GN A L+ G ++ + G L + GH MV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL G T L AA AG + +V+ +N+G V+A+ G T +A Q
Sbjct: 64 LLHKEIILETTTK-KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 214 HMKIVALM 221
H+++V +
Sbjct: 123 HLEVVKFL 130
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 95.5 bits (236), Expect = 1e-19
Identities = 52/184 (28%), Positives = 97/184 (52%), Gaps = 1/184 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A S+ +++ +Q + ++ N G+T LM A+ G+ +V +L+ G VN+
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G+ LMLA G+ + +L + GA + +D+ G TAL GH ++ +++ G
Sbjct: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
Query: 159 ANANVREPICGFTPLME-AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
+V + G+TPLM +A +G++ + ++ G V+ +D +G T M+A H ++
Sbjct: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
Query: 218 VALM 221
V L+
Sbjct: 294 VQLL 297
Score = 89.7 bits (221), Expect = 7e-18
Identities = 61/186 (32%), Positives = 94/186 (50%), Gaps = 4/186 (2%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G +VK V D+N KNG G LM A Y GH +V L G S
Sbjct: 148 LMVAAQKGYTRLVKILVSNGT-DVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDI-QGWTALFHCTS-AGHQHMVRFLLD 156
G T L A+ G+ S+ ++++ G E+++ D GWT L ++ +G+Q + L+D
Sbjct: 207 DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLID 266
Query: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
+GAN NV++ G TPLM A HE +VQ L+ G ++ G +A+ +
Sbjct: 267 AGANVNVKDRN-GKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
Query: 217 IVALMD 222
+V+L++
Sbjct: 326 VVSLLE 331
Score = 67.4 bits (163), Expect = 4e-11
Identities = 47/142 (33%), Positives = 75/142 (52%), Gaps = 3/142 (2%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
GT V+ + L A G +VVK ++R ++ GG T L +A+ GH ++
Sbjct: 167 GTDVNLKNGSGKDSLMLACYAGHLDVVKY-LRRHGASWQARDLGGCTALHWAADGGHCSV 225
Query: 85 VHLLLEAGVSVNV-PTPEGQTPLMLASSC-GNESIAYFLLQQGAELEMKDIQGWTALFHC 142
+ +++ G V+V T G TPLM S+ GN+ +A L+ GA + +KD G T L
Sbjct: 226 IEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVA 285
Query: 143 TSAGHQHMVRFLLDSGANANVR 164
H+ +V+ LLD GA+A+V+
Sbjct: 286 VLNNHEELVQLLLDKGADASVK 307
Score = 39.3 bits (90), Expect = 0.012
Identities = 20/59 (33%), Positives = 34/59 (57%)
Query: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPS 227
GFT LM AA G+ +V+ +++G V+ ++ SG + MLA GH+ +V + + S
Sbjct: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGAS 202
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 94.0 bits (232), Expect = 4e-19
Identities = 74/242 (30%), Positives = 108/242 (44%), Gaps = 13/242 (5%)
Query: 1 MSELSDEASEP------ELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKEC 54
+ E++DE P E +++ G G ++ + + T A G + V +
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
Query: 55 VQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGN 114
+ + D+ G TPLM A+ GH +V LL AG +V+ T G T L A G+
Sbjct: 553 LIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609
Query: 115 ESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLM 174
+A LLQ GA+LE + G T L AGH V+FL+ GAN N T L
Sbjct: 610 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669
Query: 175 EAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYR 234
A A GH +V+ L HG R G+T + A + GH +V + Y P +L
Sbjct: 670 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY----PNNLLS 725
Query: 235 SP 236
+P
Sbjct: 726 AP 727
Score = 90.9 bits (224), Expect = 3e-18
Identities = 60/181 (33%), Positives = 84/181 (46%), Gaps = 30/181 (16%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T LM A GH + LLL++G VN+P ++PL LA+ G+ +A L+++GA LE
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE----------PICG----------- 169
+ +G+T L GH+ MV LL GAN N + CG
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 170 ---------FTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVAL 220
TPLMEAA GH +V+Y L G V A +G TA A + GH + +
Sbjct: 556 AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
Query: 221 M 221
+
Sbjct: 616 L 616
Score = 89.0 bits (219), Expect = 1e-17
Identities = 63/183 (34%), Positives = 88/183 (48%), Gaps = 4/183 (2%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G Y V + + + N G TPLM A GH + LLLE G +N +
Sbjct: 339 TYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Query: 101 E-GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
E ++ L LA G+ + FLL+ GA+ E K + TAL GH + R LLDSGA
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 160 NANVREPICGF-TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
N+ P F +PL AA GH + + G ++ + G T M A + GH ++V
Sbjct: 459 QVNM--PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Query: 219 ALM 221
AL+
Sbjct: 517 ALL 519
Score = 88.2 bits (217), Expect = 2e-17
Identities = 57/184 (30%), Positives = 99/184 (53%), Gaps = 3/184 (1%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G +E + + + R + ++ G+TPL+ A+ GH +V +LL+ G + +
Sbjct: 1088 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 1147
Query: 101 EGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
+ TPL LA S G + + LL +GA E +++ +T L S G+ ++++ LL++GA
Sbjct: 1148 RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1207
Query: 160 NANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR-DHSGATARMLAKQYGHMKI 217
N R G +PLM AA GH V+ L+ G ++A+ + + TA LA G ++
Sbjct: 1208 EINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1267
Query: 218 VALM 221
V+L+
Sbjct: 1268 VSLL 1271
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/195 (33%), Positives = 99/195 (50%), Gaps = 11/195 (5%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA+ G ++VK + + D+N ++ G T L YA G+ +V +LLE+G S+
Sbjct: 305 LMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAEL-----EMKDIQGWTALFHCTSAGHQHMVRF 153
G TPLM A S G+ +A LL+ GA + E K+ +AL GH MVRF
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE----SALTLACYKGHLEMVRF 419
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL++GA+ + T LMEA GH + + L+ G +V+ S + LA G
Sbjct: 420 LLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 214 HMKIVALMDTYSPSL 228
H+++ AL+ SL
Sbjct: 479 HVELAALLIERGASL 493
Score = 81.3 bits (199), Expect = 3e-15
Identities = 55/154 (35%), Positives = 81/154 (52%), Gaps = 4/154 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A GH+ +V LLE G S+ +G TPL+LA++ G+ + LL GA++E
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 131 KDIQGW-TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFL 189
+ + T L S G Q +V LL GAN R + +TPL AA+ G+ I++ L
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN-VSDYTPLSLAASGGYVNIIKILL 1203
Query: 190 NHGVKVDARDHS--GATARMLAKQYGHMKIVALM 221
N G ++++R S G + MLA GH V L+
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 81.3 bits (199), Expect = 3e-15
Identities = 60/187 (32%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG--GWTPLMYASYIGHDTIVHLLLEAGVSVN 96
L AAS G ++K + ++N + G G +PLM A+ GH V LLL+ G +N
Sbjct: 1187 LSLAASGGYVNIIK-ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245
Query: 97 VPTPEGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLL 155
+ T L LA G + LL + A +E + G T L S G+ + R LL
Sbjct: 1246 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1305
Query: 156 DSGANANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGH 214
D GA+ N P T L AA GH + + G +D R+ G T LA GH
Sbjct: 1306 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1365
Query: 215 MKIVALM 221
+ +V L+
Sbjct: 1366 LDVVQLL 1372
Score = 80.5 bits (197), Expect = 5e-15
Identities = 60/197 (30%), Positives = 88/197 (44%), Gaps = 2/197 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A S G YE+ + + ++ G TPLM A+ GH IV LLL VN +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A + G + LL+ GA +E + G T L SAGH + R LL++GA
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + L A GH +V++ L G + + TA M A GH+++ L+
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 222 --DTYSPSLPKSLYRSP 236
++P + SP
Sbjct: 454 LDSGAQVNMPADSFESP 470
Score = 75.1 bits (183), Expect = 2e-13
Identities = 53/150 (35%), Positives = 72/150 (48%), Gaps = 3/150 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A + G +V LLL+ +V G TPLM A+S G + LL +GA++
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313
Query: 131 KDIQGW--TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
+ TAL GH L+ GA+ +VR G TPL AA GH +VQ
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK-GNTPLWLAANGGHLDVVQLL 1372
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G VDA D+ T M A + GH+K+V
Sbjct: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVV 1402
Score = 67.0 bits (162), Expect = 5e-11
Identities = 48/143 (33%), Positives = 70/143 (48%), Gaps = 2/143 (1%)
Query: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQG-WTA 138
G V LL G SVN T EG++ L LA S G +A LL A +E + I+G T
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L + GH +V+ LL A+ N + G T L A A G+ +V+ L G ++
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
+ +G T M A GH+++ L+
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLL 386
Score = 64.7 bits (156), Expect = 3e-10
Identities = 44/146 (30%), Positives = 79/146 (54%), Gaps = 4/146 (2%)
Query: 46 GQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP-TPEGQ- 103
G+ EVV + R+ ++ + G TPLM A+ G+ + +LL+ G VN P P +
Sbjct: 1263 GRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1321
Query: 104 TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANV 163
T L +A+ G+ L+ +GA +++++ +G T L+ + GH +V+ L+ +GA+ +
Sbjct: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381
Query: 164 REPICGFTPLMEAAAAGHEIIVQYFL 189
+ TPLM A GH +V+Y +
Sbjct: 1382 ADNR-KITPLMAAFRKGHVKVVRYLV 1406
Score = 49.7 bits (117), Expect = 9e-06
Identities = 37/116 (31%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 108 LASSC--GNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
LA +C G+ + LL +G + +G + L SAG+ + + LL AN R
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPLM AA GH IV+ L H V+A+ +G TA A G++ +V ++
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 39 LHTAASIGQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
L AA G Y+ + + R +D+ K G TPL A+ GH +V LL++AG V+
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGN--TPLWLAANGGHLDVVQLLVQAGADVDA 1381
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQ 124
TPLM A G+ + +L+++
Sbjct: 1382 ADNRKITPLMAAFRKGHVKVVRYLVKE 1408
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 94.0 bits (232), Expect = 4e-19
Identities = 74/242 (30%), Positives = 108/242 (44%), Gaps = 13/242 (5%)
Query: 1 MSELSDEASEP------ELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKEC 54
+ E++DE P E +++ G G ++ + + T A G + V +
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
Query: 55 VQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGN 114
+ + D+ G TPLM A+ GH +V LL AG +V+ T G T L A G+
Sbjct: 553 LIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609
Query: 115 ESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLM 174
+A LLQ GA+LE + G T L AGH V+FL+ GAN N T L
Sbjct: 610 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669
Query: 175 EAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYR 234
A A GH +V+ L HG R G+T + A + GH +V + Y P +L
Sbjct: 670 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY----PNNLLS 725
Query: 235 SP 236
+P
Sbjct: 726 AP 727
Score = 90.9 bits (224), Expect = 3e-18
Identities = 60/181 (33%), Positives = 84/181 (46%), Gaps = 30/181 (16%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T LM A GH + LLL++G VN+P ++PL LA+ G+ +A L+++GA LE
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE----------PICG----------- 169
+ +G+T L GH+ MV LL GAN N + CG
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 170 ---------FTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVAL 220
TPLMEAA GH +V+Y L G V A +G TA A + GH + +
Sbjct: 556 AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
Query: 221 M 221
+
Sbjct: 616 L 616
Score = 89.0 bits (219), Expect = 1e-17
Identities = 63/183 (34%), Positives = 88/183 (48%), Gaps = 4/183 (2%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G Y V + + + N G TPLM A GH + LLLE G +N +
Sbjct: 339 TYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Query: 101 E-GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
E ++ L LA G+ + FLL+ GA+ E K + TAL GH + R LLDSGA
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 160 NANVREPICGF-TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
N+ P F +PL AA GH + + G ++ + G T M A + GH ++V
Sbjct: 459 QVNM--PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Query: 219 ALM 221
AL+
Sbjct: 517 ALL 519
Score = 88.2 bits (217), Expect = 2e-17
Identities = 57/184 (30%), Positives = 99/184 (53%), Gaps = 3/184 (1%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G +E + + + R + ++ G+TPL+ A+ GH +V +LL+ G + +
Sbjct: 837 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 896
Query: 101 EGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
+ TPL LA S G + + LL +GA E +++ +T L S G+ ++++ LL++GA
Sbjct: 897 RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 956
Query: 160 NANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR-DHSGATARMLAKQYGHMKI 217
N R G +PLM AA GH V+ L+ G ++A+ + + TA LA G ++
Sbjct: 957 EINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1016
Query: 218 VALM 221
V+L+
Sbjct: 1017 VSLL 1020
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/195 (33%), Positives = 99/195 (50%), Gaps = 11/195 (5%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA+ G ++VK + + D+N ++ G T L YA G+ +V +LLE+G S+
Sbjct: 305 LMAAANGGHVKIVKLLLAHKA-DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAEL-----EMKDIQGWTALFHCTSAGHQHMVRF 153
G TPLM A S G+ +A LL+ GA + E K+ +AL GH MVRF
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE----SALTLACYKGHLEMVRF 419
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL++GA+ + T LMEA GH + + L+ G +V+ S + LA G
Sbjct: 420 LLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 214 HMKIVALMDTYSPSL 228
H+++ AL+ SL
Sbjct: 479 HVELAALLIERGASL 493
Score = 81.3 bits (199), Expect = 3e-15
Identities = 55/154 (35%), Positives = 81/154 (52%), Gaps = 4/154 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A GH+ +V LLE G S+ +G TPL+LA++ G+ + LL GA++E
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 131 KDIQGW-TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFL 189
+ + T L S G Q +V LL GAN R + +TPL AA+ G+ I++ L
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN-VSDYTPLSLAASGGYVNIIKILL 952
Query: 190 NHGVKVDARDHS--GATARMLAKQYGHMKIVALM 221
N G ++++R S G + MLA GH V L+
Sbjct: 953 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 81.3 bits (199), Expect = 3e-15
Identities = 60/187 (32%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG--GWTPLMYASYIGHDTIVHLLLEAGVSVN 96
L AAS G ++K + ++N + G G +PLM A+ GH V LLL+ G +N
Sbjct: 936 LSLAASGGYVNIIK-ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994
Query: 97 VPTPEGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLL 155
+ T L LA G + LL + A +E + G T L S G+ + R LL
Sbjct: 995 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1054
Query: 156 DSGANANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGH 214
D GA+ N P T L AA GH + + G +D R+ G T LA GH
Sbjct: 1055 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1114
Query: 215 MKIVALM 221
+ +V L+
Sbjct: 1115 LDVVQLL 1121
Score = 80.5 bits (197), Expect = 5e-15
Identities = 60/197 (30%), Positives = 88/197 (44%), Gaps = 2/197 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A S G YE+ + + ++ G TPLM A+ GH IV LLL VN +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A + G + LL+ GA +E + G T L SAGH + R LL++GA
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + L A GH +V++ L G + + TA M A GH+++ L+
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 222 --DTYSPSLPKSLYRSP 236
++P + SP
Sbjct: 454 LDSGAQVNMPADSFESP 470
Score = 75.1 bits (183), Expect = 2e-13
Identities = 53/150 (35%), Positives = 72/150 (48%), Gaps = 3/150 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A + G +V LLL+ +V G TPLM A+S G + LL +GA++
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1062
Query: 131 KDIQGW--TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
+ TAL GH L+ GA+ +VR G TPL AA GH +VQ
Sbjct: 1063 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK-GNTPLWLAANGGHLDVVQLL 1121
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G VDA D+ T M A + GH+K+V
Sbjct: 1122 VQAGADVDAADNRKITPLMAAFRKGHVKVV 1151
Score = 67.0 bits (162), Expect = 5e-11
Identities = 48/143 (33%), Positives = 70/143 (48%), Gaps = 2/143 (1%)
Query: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQG-WTA 138
G V LL G SVN T EG++ L LA S G +A LL A +E + I+G T
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L + GH +V+ LL A+ N + G T L A A G+ +V+ L G ++
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
+ +G T M A GH+++ L+
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLL 386
Score = 64.7 bits (156), Expect = 3e-10
Identities = 44/146 (30%), Positives = 79/146 (54%), Gaps = 4/146 (2%)
Query: 46 GQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP-TPEGQ- 103
G+ EVV + R+ ++ + G TPLM A+ G+ + +LL+ G VN P P +
Sbjct: 1012 GRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1070
Query: 104 TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANV 163
T L +A+ G+ L+ +GA +++++ +G T L+ + GH +V+ L+ +GA+ +
Sbjct: 1071 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1130
Query: 164 REPICGFTPLMEAAAAGHEIIVQYFL 189
+ TPLM A GH +V+Y +
Sbjct: 1131 ADNR-KITPLMAAFRKGHVKVVRYLV 1155
Score = 49.7 bits (117), Expect = 9e-06
Identities = 37/116 (31%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 108 LASSC--GNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
LA +C G+ + LL +G + +G + L SAG+ + + LL AN R
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPLM AA GH IV+ L H V+A+ +G TA A G++ +V ++
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 39 LHTAASIGQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
L AA G Y+ + + R +D+ K G TPL A+ GH +V LL++AG V+
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGN--TPLWLAANGGHLDVVQLLVQAGADVDA 1130
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQ 124
TPLM A G+ + +L+++
Sbjct: 1131 ADNRKITPLMAAFRKGHVKVVRYLVKE 1157
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 92.8 bits (229), Expect = 9e-19
Identities = 63/194 (32%), Positives = 97/194 (50%), Gaps = 2/194 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G + E+LD L +A+ G +V+E + + ++L ++ GGWT LM+A Y G +
Sbjct: 61 GANCNLEDLDNWTALISASKEGHVHIVEELL-KCGVNLEHRDMGGWTALMWACYKGRTDV 119
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
V LLL G + +V P++ A+ G+ I + LLQ GA++ D G T L
Sbjct: 120 VELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAAR 179
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH V+ LL GA+ + +E T L+ A G+ V+ L V+ D G T
Sbjct: 180 KGHLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNT 238
Query: 205 ARMLAKQYGHMKIV 218
A M+A + GH +IV
Sbjct: 239 ALMIASKEGHTEIV 252
Score = 89.4 bits (220), Expect = 1e-17
Identities = 57/158 (36%), Positives = 84/158 (53%), Gaps = 1/158 (0%)
Query: 61 DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF 120
D++++N G TPLM A+ G+ IV L++ G + N+ + T L+ AS G+ I
Sbjct: 30 DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
Query: 121 LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAG 180
LL+ G LE +D+ GWTAL G +V LL GAN +V + P++ AA G
Sbjct: 90 LLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGLYSVYPIIWAAGRG 148
Query: 181 HEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
H IV L +G KV+ D G T + A + GH++ V
Sbjct: 149 HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECV 186
Score = 82.0 bits (201), Expect = 2e-15
Identities = 70/214 (32%), Positives = 103/214 (48%), Gaps = 9/214 (4%)
Query: 24 LGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDT 83
+G V E + L A G + VKE ++R ++N + G T LM AS GH
Sbjct: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNP-NVNLTDKDGNTALMIASKEGHTE 250
Query: 84 IVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCT 143
IV LL+AG VN+P G T L+ A G+ I LLQ+ A+++++ TAL+
Sbjct: 251 IVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
Query: 144 SAGHQHMVRFLLDSGANANVREPIC---GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDH 200
G+ MVR +L N IC G TPL++A + +V+ L+ G KV A D
Sbjct: 311 EKGNATMVRDIL----QCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
Query: 201 SGATARMLAKQYGHMKIVALMDTYSPSLPKSLYR 234
G T +A + K+ L+ +P + LYR
Sbjct: 367 KGDTPLHIAIRGRSRKLAELL-LRNPKDGRLLYR 399
Score = 74.7 bits (182), Expect = 2e-13
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 77 SYIGHDTIVHL--LLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQ 134
+Y+ + I L LLE V+ GQTPLM+A+ GN I L++ GA ++D+
Sbjct: 11 NYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD 70
Query: 135 GWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVK 194
WTAL + GH H+V LL G N R+ + G+T LM A G +V+ L+HG
Sbjct: 71 NWTALISASKEGHVHIVEELLKCGVNLEHRD-MGGWTALMWACYKGRTDVVELLLSHGAN 129
Query: 195 VDARDHSGATARMLAKQYGHMKIVALM 221
+ A GH IV L+
Sbjct: 130 PSVTGLYSVYPIIWAAGRGHADIVHLL 156
Score = 66.6 bits (161), Expect = 7e-11
Identities = 58/201 (28%), Positives = 89/201 (44%), Gaps = 4/201 (1%)
Query: 18 LSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYAS 77
L + HG V+G P+ AA G ++V +Q +N + G TPL++A+
Sbjct: 122 LLLSHGANPSVTGLYSVYPIIW--AAGRGHADIVHLLLQNGA-KVNCSDKYGTTPLVWAA 178
Query: 78 YIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWT 137
GH V LL G V+ T L++A G +L++ + + D G T
Sbjct: 179 RKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNT 238
Query: 138 ALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDA 197
AL + GH +V+ LLD+G N+ + G T L+ A GH IV+ L +D
Sbjct: 239 ALMIASKEGHTEIVQDLLDAGTYVNIPDR-SGDTVLIGAVRGGHVEIVRALLQKYADIDI 297
Query: 198 RDHSGATARMLAKQYGHMKIV 218
R TA A + G+ +V
Sbjct: 298 RGQDNKTALYWAVEKGNATMV 318
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/190 (32%), Positives = 92/190 (48%), Gaps = 2/190 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G + V+E V + D+N + G T L +A+ GH+ +V L G S
Sbjct: 50 LMVAAYAGHIDCVRELVLQGA-DINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFR 108
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T +G T L+ AS G+ + LL+ GA + + G TALF G+ ++R LL SG
Sbjct: 109 TKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASG 168
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N G PL A+ GH +V+ L G DA + G TA + A G+ ++
Sbjct: 169 AKVNQPRQD-GTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVI 227
Query: 219 ALMDTYSPSL 228
+ +SP+L
Sbjct: 228 KELLKFSPTL 237
Score = 86.7 bits (213), Expect = 6e-17
Identities = 56/180 (31%), Positives = 85/180 (47%), Gaps = 1/180 (0%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
AA G ++K + +D++ ++ G T LM A+Y GH V L+ G +N+
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A+ G+ + FL GA E + G TAL + GH +V LL GAN
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
+ + G T L AA G+ +++ L G KV+ G +A Q GH ++V +M
Sbjct: 139 H-DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
Score = 67.4 bits (163), Expect = 4e-11
Identities = 44/136 (32%), Positives = 67/136 (49%), Gaps = 6/136 (4%)
Query: 103 QTPL----MLASSCGNESIAYFLLQQG-AELEMKDIQGWTALFHCTSAGHQHMVRFLLDS 157
+TPL A+ GN ++ LL G +++ +D G T L AGH VR L+
Sbjct: 9 ETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ 68
Query: 158 GANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
GA+ N++ G T L AA GH +V++ G + R G TA + A QYGHM++
Sbjct: 69 GADINLQRE-SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQV 127
Query: 218 VALMDTYSPSLPKSLY 233
V + + ++ LY
Sbjct: 128 VETLLKHGANIHDQLY 143
Score = 60.1 bits (144), Expect = 6e-09
Identities = 47/188 (25%), Positives = 80/188 (42%), Gaps = 3/188 (1%)
Query: 23 GLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHD 82
G G D L A+ G +VV E + + +++ + G T L A+ G+
Sbjct: 100 GFGASTEFRTKDGGTALLAASQYGHMQVV-ETLLKHGANIHDQLYDGATALFLAAQGGYL 158
Query: 83 TIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHC 142
++ LLL +G VN P +G PL +AS G+ + +L +GA+ + G TAL
Sbjct: 159 DVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKA 218
Query: 143 TSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSG 202
+ G+ +++ LL + + G + L A +G+ V L G R+ +
Sbjct: 219 ANKGYNDVIKELLKFSPTLGILKN--GTSALHAAVLSGNIKTVALLLEAGADPSLRNKAN 276
Query: 203 ATARMLAK 210
L K
Sbjct: 277 ELPAELTK 284
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 90.9 bits (224), Expect = 3e-18
Identities = 60/197 (30%), Positives = 97/197 (49%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G QV + D LH +A +G+ ++V++ +Q+ N G+TPL ++ GH+ +
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP-NAATTSGYTPLHLSAREGHEDV 547
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
LL+ G S+++ T +G TPL +A+ G +A LLQ+ A + G T L
Sbjct: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
+Q + LLD GA+ + G+TPL AA I L +G +A G
Sbjct: 608 YDNQKVALLLLDQGASPHAAAK-NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIA 666
Query: 205 ARMLAKQYGHMKIVALM 221
+ LA Q GH+ +V+L+
Sbjct: 667 SVHLAAQEGHVDMVSLL 683
Score = 88.6 bits (218), Expect = 2e-17
Identities = 54/183 (29%), Positives = 88/183 (48%), Gaps = 2/183 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A + +V+ E + + + G TP+ A+++GH IV L+ G S N
Sbjct: 404 LHIACKKNRIKVM-ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G+T L +A+ G + +L+Q GA++E K T L G +V+ LL G
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N G+TPL +A GHE + + L+HG + G T +A +YG +++
Sbjct: 523 ASPNA-ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 219 ALM 221
L+
Sbjct: 582 NLL 584
Score = 87.0 bits (214), Expect = 5e-17
Identities = 60/190 (31%), Positives = 91/190 (47%), Gaps = 2/190 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA G Y+V K + ++ + N K G+TPL A ++ LLL+ G S+
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKA-NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G TP+ +A+ G+ +I L+ GA +++G TAL +G +VR+L+ G
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A + TPL +A G IVQ L G +A SG T L+ + GH +
Sbjct: 490 AQVEAKAK-DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 219 ALMDTYSPSL 228
A + + SL
Sbjct: 549 AFLLDHGASL 558
Score = 86.7 bits (213), Expect = 6e-17
Identities = 63/204 (30%), Positives = 88/204 (43%), Gaps = 4/204 (1%)
Query: 18 LSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYAS 77
L + HG Q E P+ H AA +G +V + + N N G T L A+
Sbjct: 418 LLLKHGASIQAVTESGLTPI--HVAAFMGHVNIVSQ-LMHHGASPNTTNVRGETALHMAA 474
Query: 78 YIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWT 137
G +V L++ G V + QTPL +++ G I LLQQGA G+T
Sbjct: 475 RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534
Query: 138 ALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDA 197
L GH+ + FLLD GA+ ++ GFTPL AA G + L DA
Sbjct: 535 PLHLSAREGHEDVAAFLLDHGASLSITTK-KGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 198 RDHSGATARMLAKQYGHMKIVALM 221
SG T +A Y + K+ L+
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLL 617
Score = 85.5 bits (210), Expect = 1e-16
Identities = 62/204 (30%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 22 HGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGH 81
HG ++ ++ PL H AA G+ EV +Q+ + G TPL A++ +
Sbjct: 554 HGASLSITTKKGFTPL--HVAAKYGKLEVANLLLQK-SASPDAAGKSGLTPLHVAAHYDN 610
Query: 82 DTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFH 141
+ LLL+ G S + G TPL +A+ IA LL+ GA+ QG ++
Sbjct: 611 QKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670
Query: 142 CTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHS 201
GH MV LL AN N+ G TPL AA + + +N G VDA+
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNK-SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 202 GATARMLAKQYGHMKIVALMDTYS 225
G T + YG++KIV + +S
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHS 753
Score = 79.0 bits (193), Expect = 1e-14
Identities = 54/181 (29%), Positives = 83/181 (45%), Gaps = 2/181 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH A+ G +VK + R ++ K G TPL + GH+ +V +LL+ +
Sbjct: 272 LHVASKRGNANMVKLLLDRGA-KIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
T G +PL +A+ + + LLQ ++ TAL GH + + LLD
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN N + + GFTPL A +++ L HG + A SG T +A GH+ IV
Sbjct: 391 ANPNAK-ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 219 A 219
+
Sbjct: 450 S 450
Score = 77.4 bits (189), Expect = 4e-14
Identities = 57/209 (27%), Positives = 88/209 (42%), Gaps = 31/209 (14%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
AA G E + + + +D+N N G L AS GH +V LL+ +V+ T +
Sbjct: 48 AARAGHLEKALDYI-KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK 106
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L +AS G + L+ GA + + G+T L+ H +V+FLLD+GA+
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVK--------------------------- 194
++ GFTPL A GH+ +V L + K
Sbjct: 167 SLATE-DGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQND 225
Query: 195 --VDARDHSGATARMLAKQYGHMKIVALM 221
D SG T +A YG++ + L+
Sbjct: 226 NNADVESKSGFTPLHIAAHYGNINVATLL 254
Score = 77.4 bits (189), Expect = 4e-14
Identities = 57/184 (30%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 39 LHTAASIGQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
LH AA + +Q D+ K+G +TPL A++ G+ + LLL +V+
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSG--FTPLHIAAHYGNINVATLLLNRAAAVDF 263
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDS 157
TPL +AS GN ++ LL +GA+++ K G T L +GH+ +V LLD
Sbjct: 264 TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Query: 158 GANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
A + + G +PL A H VQ L H V VD + TA +A GH K+
Sbjct: 324 AAPI-LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382
Query: 218 VALM 221
++
Sbjct: 383 AKVL 386
Score = 77.0 bits (188), Expect = 5e-14
Identities = 54/180 (30%), Positives = 86/180 (47%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AA Q ++ ++ D N G + A+ GH +V LLL +VN+
Sbjct: 635 LHIAAKKNQMDIATTLLEYGA-DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS 693
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G TPL LA+ ++A L+ QGA ++ + G+T L G+ +V FLL
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHS 753
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A N + G+TPL +AA GH I+ L + + +G TA +A++ G++ +V
Sbjct: 754 AKVNAKTK-NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 812
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/148 (27%), Positives = 68/148 (45%), Gaps = 1/148 (0%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A++ GH + +LL+ + N G TPL +A + LL+ GA ++
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
G T + GH ++V L+ GA+ N + G T L AA +G +V+Y +
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN-VRGETALHMAARSGQAEVVRYLVQ 487
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIV 218
G +V+A+ T ++ + G IV
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIV 515
Score = 31.2 bits (69), Expect = 3.2
Identities = 22/79 (27%), Positives = 33/79 (41%), Gaps = 1/79 (1%)
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
AGH + +G + N+ G L A+ GH +V L VDA G T
Sbjct: 51 AGHLEKALDYIKNGVDINICNQN-GLNALHLASKEGHVEVVSELLQREANVDAATKKGNT 109
Query: 205 ARMLAKQYGHMKIVALMDT 223
A +A G ++V ++ T
Sbjct: 110 ALHIASLAGQAEVVKVLVT 128
Score = 30.0 bits (66), Expect = 7.0
Identities = 14/46 (30%), Positives = 27/46 (58%)
Query: 174 MEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVA 219
+ AA AGH ++ +GV ++ + +G A LA + GH+++V+
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVS 91
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 90.9 bits (224), Expect = 3e-18
Identities = 69/230 (30%), Positives = 103/230 (44%), Gaps = 9/230 (3%)
Query: 1 MSELSDEASEP------ELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKEC 54
+ E++DE P E +++ G ++ + + T A G + V +
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 55 VQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGN 114
+ + D+ G TPLM AS GH +V LL +G +V+ T G T L A G+
Sbjct: 524 LIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580
Query: 115 ESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLM 174
+A LLQ GA+LE + G T L AGH V+FL+ GAN N T +
Sbjct: 581 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVS 640
Query: 175 EAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTY 224
A A GH +V+ L HG R G+T + A + GH +V+ + Y
Sbjct: 641 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 90.5 bits (223), Expect = 4e-18
Identities = 69/230 (30%), Positives = 99/230 (43%), Gaps = 32/230 (13%)
Query: 22 HGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGH 81
HG G E L A G ++V+ ++ D K T LM A GH
Sbjct: 360 HGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGA-DQEHKTDEMHTALMEACMDGH 417
Query: 82 DTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFH 141
+ LLL++G VN+P ++PL LA+ G+ +A L+++GA LE + +G+T L
Sbjct: 418 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
Query: 142 CTSAGHQHMVRFLLDSGANANVRE----------PICG--------------------FT 171
GH+ MV LL GAN N + CG T
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
PLMEA+ GH +V+Y L G V A +G TA A + GH + ++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 4/183 (2%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G + + + + ++ N G TPLM A+ GH + +LL+ G +N +
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 101 E-GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
E ++ L LA G+ + FLL+ GA+ E K + TAL GH + R LLDSGA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 160 NANVREPICGF-TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
N+ P F +PL AA GH + + G ++ + G T M A + GH ++V
Sbjct: 430 QVNM--PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487
Query: 219 ALM 221
AL+
Sbjct: 488 ALL 490
Score = 85.5 bits (210), Expect = 1e-16
Identities = 57/184 (30%), Positives = 99/184 (53%), Gaps = 3/184 (1%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G +E + + R+ + ++ G+TPL+ A+ GH +V +LL+ G + +
Sbjct: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
Query: 101 EGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
+ TPL LA S G + + LL +GA E +++ +T L S G+ ++++ LL++GA
Sbjct: 1120 RTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1179
Query: 160 NANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR-DHSGATARMLAKQYGHMKI 217
N R G +PLM AA GH V+ L+ G ++A+ + + TA LA G ++
Sbjct: 1180 EINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEV 1239
Query: 218 VALM 221
V+L+
Sbjct: 1240 VSLL 1243
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/197 (31%), Positives = 88/197 (44%), Gaps = 2/197 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A S G YE+ + + ++ N G TPLM AS G+ IV LLL VN +
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A + G I LL +GA +E + G T L SAGH + R LLD GA
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + L A GH +V++ L G + + TA M A GH+++ L+
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 222 --DTYSPSLPKSLYRSP 236
++P + SP
Sbjct: 425 LDSGAQVNMPADSFESP 441
Score = 80.1 bits (196), Expect = 6e-15
Identities = 60/187 (32%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG--GWTPLMYASYIGHDTIVHLLLEAGVSVN 96
L AAS G ++K + ++N + G G +PLM A+ GH V LLL+ G +N
Sbjct: 1159 LSLAASGGYVNIIK-ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 97 VPTPEGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLL 155
+ T L LA G + LL + A +E + G T L S G+ + R LL
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
Query: 156 DSGANANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGH 214
D GA+ N P T L AA GH + ++ G +D R+ G T LA GH
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
Query: 215 MKIVALM 221
+V L+
Sbjct: 1338 FDVVQLL 1344
Score = 73.2 bits (178), Expect = 7e-13
Identities = 50/154 (32%), Positives = 80/154 (51%), Gaps = 4/154 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A GH+ +V +L+ + +G TPL+LA++ G+ + LL +G ++E
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 131 KDIQGW-TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFL 189
+ + T L S G Q +V LL GAN R + +TPL AA+ G+ I++ L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN-VSDYTPLSLAASGGYVNIIKILL 1175
Query: 190 NHGVKVDARDHS--GATARMLAKQYGHMKIVALM 221
N G ++++R S G + MLA GH+ V L+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Score = 73.2 bits (178), Expect = 7e-13
Identities = 52/150 (34%), Positives = 72/150 (48%), Gaps = 3/150 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A + G +V LLL+ +V G TPLM A+S G + LL +GA++
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285
Query: 131 KDIQGW--TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
+ TAL GH L+ GA+ +VR G TPL A+ GH +VQ
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKK-GNTPLWLASNGGHFDVVQLL 1344
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G VDA D+ T M A + GH+K+V
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/146 (30%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 46 GQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP-TPEGQ- 103
G+ EVV + R+ ++ + G TPLM A+ G+ + +LL+ G VN P P +
Sbjct: 1235 GRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 104 TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANV 163
T L +A+ G+ L+ +GA +++++ +G T L+ ++ GH +V+ L+ +GA+ +
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 164 REPICGFTPLMEAAAAGHEIIVQYFL 189
+ TPLM A GH +VQY +
Sbjct: 1354 ADNR-KITPLMSAFRKGHVKVVQYLV 1378
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/143 (33%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQG-WTA 138
G V LL+ G SVN T EG++ L LA S G +A LL A +E + +G T
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L +S G+ +V+ LL A+ N + G T L A A G IV+ LN G ++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
+ +G T M A GH+++ ++
Sbjct: 335 NENGHTPLMEAASAGHVEVARVL 357
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 108 LASSC--GNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
LA +C G+ + LL +G + +G + L SAG+ + + LL AN R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPLM A++ G+ IV+ L H V+++ +G TA A G + IV ++
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 39 LHTAASIGQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
L AA G Y+ + + R +D+ K G TPL AS GH +V LL++AG V+
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGN--TPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQ 124
TPLM A G+ + +L+++
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 90.9 bits (224), Expect = 3e-18
Identities = 69/230 (30%), Positives = 103/230 (44%), Gaps = 9/230 (3%)
Query: 1 MSELSDEASEP------ELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKEC 54
+ E++DE P E +++ G ++ + + T A G + V +
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 55 VQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGN 114
+ + D+ G TPLM AS GH +V LL +G +V+ T G T L A G+
Sbjct: 524 LIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580
Query: 115 ESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLM 174
+A LLQ GA+LE + G T L AGH V+FL+ GAN N T +
Sbjct: 581 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVS 640
Query: 175 EAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTY 224
A A GH +V+ L HG R G+T + A + GH +V+ + Y
Sbjct: 641 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 90.5 bits (223), Expect = 4e-18
Identities = 69/230 (30%), Positives = 99/230 (43%), Gaps = 32/230 (13%)
Query: 22 HGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGH 81
HG G E L A G ++V+ ++ D K T LM A GH
Sbjct: 360 HGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGA-DQEHKTDEMHTALMEACMDGH 417
Query: 82 DTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFH 141
+ LLL++G VN+P ++PL LA+ G+ +A L+++GA LE + +G+T L
Sbjct: 418 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
Query: 142 CTSAGHQHMVRFLLDSGANANVRE----------PICG--------------------FT 171
GH+ MV LL GAN N + CG T
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
PLMEA+ GH +V+Y L G V A +G TA A + GH + ++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 4/183 (2%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G + + + + ++ N G TPLM A+ GH + +LL+ G +N +
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 101 E-GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
E ++ L LA G+ + FLL+ GA+ E K + TAL GH + R LLDSGA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 160 NANVREPICGF-TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
N+ P F +PL AA GH + + G ++ + G T M A + GH ++V
Sbjct: 430 QVNM--PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487
Query: 219 ALM 221
AL+
Sbjct: 488 ALL 490
Score = 85.5 bits (210), Expect = 1e-16
Identities = 57/184 (30%), Positives = 99/184 (53%), Gaps = 3/184 (1%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G +E + + R+ + ++ G+TPL+ A+ GH +V +LL+ G + +
Sbjct: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
Query: 101 EGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
+ TPL LA S G + + LL +GA E +++ +T L S G+ ++++ LL++GA
Sbjct: 1120 RTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1179
Query: 160 NANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR-DHSGATARMLAKQYGHMKI 217
N R G +PLM AA GH V+ L+ G ++A+ + + TA LA G ++
Sbjct: 1180 EINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEV 1239
Query: 218 VALM 221
V+L+
Sbjct: 1240 VSLL 1243
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/197 (31%), Positives = 88/197 (44%), Gaps = 2/197 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A S G YE+ + + ++ N G TPLM AS G+ IV LLL VN +
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A + G I LL +GA +E + G T L SAGH + R LLD GA
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + L A GH +V++ L G + + TA M A GH+++ L+
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 222 --DTYSPSLPKSLYRSP 236
++P + SP
Sbjct: 425 LDSGAQVNMPADSFESP 441
Score = 80.1 bits (196), Expect = 6e-15
Identities = 60/187 (32%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG--GWTPLMYASYIGHDTIVHLLLEAGVSVN 96
L AAS G ++K + ++N + G G +PLM A+ GH V LLL+ G +N
Sbjct: 1159 LSLAASGGYVNIIK-ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 97 VPTPEGQ-TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLL 155
+ T L LA G + LL + A +E + G T L S G+ + R LL
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
Query: 156 DSGANANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGH 214
D GA+ N P T L AA GH + ++ G +D R+ G T LA GH
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
Query: 215 MKIVALM 221
+V L+
Sbjct: 1338 FDVVQLL 1344
Score = 73.2 bits (178), Expect = 7e-13
Identities = 50/154 (32%), Positives = 80/154 (51%), Gaps = 4/154 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A GH+ +V +L+ + +G TPL+LA++ G+ + LL +G ++E
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 131 KDIQGW-TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFL 189
+ + T L S G Q +V LL GAN R + +TPL AA+ G+ I++ L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN-VSDYTPLSLAASGGYVNIIKILL 1175
Query: 190 NHGVKVDARDHS--GATARMLAKQYGHMKIVALM 221
N G ++++R S G + MLA GH+ V L+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Score = 73.2 bits (178), Expect = 7e-13
Identities = 52/150 (34%), Positives = 72/150 (48%), Gaps = 3/150 (2%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L A + G +V LLL+ +V G TPLM A+S G + LL +GA++
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285
Query: 131 KDIQGW--TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYF 188
+ TAL GH L+ GA+ +VR G TPL A+ GH +VQ
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKK-GNTPLWLASNGGHFDVVQLL 1344
Query: 189 LNHGVKVDARDHSGATARMLAKQYGHMKIV 218
+ G VDA D+ T M A + GH+K+V
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/146 (30%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 46 GQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP-TPEGQ- 103
G+ EVV + R+ ++ + G TPLM A+ G+ + +LL+ G VN P P +
Sbjct: 1235 GRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 104 TPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANV 163
T L +A+ G+ L+ +GA +++++ +G T L+ ++ GH +V+ L+ +GA+ +
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 164 REPICGFTPLMEAAAAGHEIIVQYFL 189
+ TPLM A GH +VQY +
Sbjct: 1354 ADNR-KITPLMSAFRKGHVKVVQYLV 1378
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/143 (33%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQG-WTA 138
G V LL+ G SVN T EG++ L LA S G +A LL A +E + +G T
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L +S G+ +V+ LL A+ N + G T L A A G IV+ LN G ++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
+ +G T M A GH+++ ++
Sbjct: 335 NENGHTPLMEAASAGHVEVARVL 357
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 108 LASSC--GNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
LA +C G+ + LL +G + +G + L SAG+ + + LL AN R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPLM A++ G+ IV+ L H V+++ +G TA A G + IV ++
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 39 LHTAASIGQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
L AA G Y+ + + R +D+ K G TPL AS GH +V LL++AG V+
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGN--TPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQ 124
TPLM A G+ + +L+++
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 90.5 bits (223), Expect = 4e-18
Identities = 62/190 (32%), Positives = 93/190 (48%), Gaps = 2/190 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LHTAA+ G+Y + K + R L GWTPL A+Y GH I+HLL E+ ++
Sbjct: 564 LHTAAARGKYLICKMLL-RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
TPL LA+ G E++ LLQ GA+ + GWT L V LL+
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
AN + R + G+TP AA G+ I++ + G ++D +D T LA + I+
Sbjct: 683 ANVHARNKV-GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM 741
Query: 219 ALMDTYSPSL 228
+ ++ PS+
Sbjct: 742 SFLEGKEPSV 751
Score = 81.6 bits (200), Expect = 2e-15
Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 32/193 (16%)
Query: 61 DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF 120
D N+ + GW PL +A+ G D LLL+ G V+ EG TPL LA+ E++A
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 121 LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA-----NANVREPI-------- 167
L+ + A+ + + +G T L GH +V+ L GA N+R P+
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 168 -------------------CGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARML 208
G+ PL AAA G +I + L +G ++ H G T L
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 209 AKQYGHMKIVALM 221
A GH++I+ L+
Sbjct: 600 AAYKGHLEIIHLL 612
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/180 (28%), Positives = 89/180 (49%), Gaps = 2/180 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH + G E V+ + E+D++ + G+TPL+ A+ + LLL G N
Sbjct: 366 LHFLVAQGSVEQVR-LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+G PL A+ G++ A LL GA ++ ++ +GWT L +++ R L+
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
A+ N+ E G TPL AA GH +V+ + G ++DA+ + T LA + G ++ +
Sbjct: 485 ADPNLHEAE-GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Score = 77.8 bits (190), Expect = 3e-14
Identities = 67/220 (30%), Positives = 89/220 (40%), Gaps = 35/220 (15%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G V +E + LH AA +E V + R+ D N G TPL A+Y GH ++
Sbjct: 451 GACVDAQEREGWTPLHLAAQ-NNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509
Query: 85 VHLLLEAGVSV-----NVPTP----------------------------EGQTPLMLASS 111
V LL G + N+ TP G PL A++
Sbjct: 510 VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
Query: 112 CGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFT 171
G I LL+ GA LE+ QGWT L GH ++ L +S AN + +T
Sbjct: 570 RGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAV-NWT 628
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQ 211
PL AA G E +V L G +A + SG T LA Q
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668
Score = 73.2 bits (178), Expect = 7e-13
Identities = 55/197 (27%), Positives = 90/197 (45%), Gaps = 2/197 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G ++ ++ ++ LH A G+ ++ ++ + + + G+ PL A+ G I
Sbjct: 517 GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP-DALDQSGYGPLHTAAARGKYLI 575
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+LL G S+ +PT +G TPL LA+ G+ I + L + A + WT L
Sbjct: 576 CKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAAR 635
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
G + +V LL GA+ N E G+TPL A + V L H V AR+ G T
Sbjct: 636 HGEEAVVSALLQCGADPNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694
Query: 205 ARMLAKQYGHMKIVALM 221
LA G+ I+ ++
Sbjct: 695 PAHLAALKGNTAILKVL 711
Score = 68.9 bits (167), Expect = 1e-11
Identities = 47/158 (29%), Positives = 69/158 (43%), Gaps = 1/158 (0%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
TPL + G V LLL V V+ T G TPL++A+ + LL GA+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 190
D GW L G R LLD GA + +E G+TPL AA E + + ++
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLVS 482
Query: 191 HGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
+ + G T +A +GH+ +V L+ + L
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 90.5 bits (223), Expect = 4e-18
Identities = 69/230 (30%), Positives = 99/230 (43%), Gaps = 32/230 (13%)
Query: 22 HGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGH 81
HG G E L A G ++V+ ++ D K T LM A GH
Sbjct: 360 HGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGA-DQEHKTDEMHTALMEACMDGH 417
Query: 82 DTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFH 141
+ LLL++G VN+P ++PL LA+ G+ +A L+++GA LE + +G+T L
Sbjct: 418 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
Query: 142 CTSAGHQHMVRFLLDSGANANVRE----------PICG--------------------FT 171
GH+ MV LL GAN N + CG T
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
PLMEA+ GH +V+Y L G V A +G TA A + GH + ++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 4/183 (2%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G + + + + ++ N G TPLM A+ GH + +LL+ G +N +
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 101 E-GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
E ++ L LA G+ + FLL+ GA+ E K + TAL GH + R LLDSGA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 160 NANVREPICGF-TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
N+ P F +PL AA GH + + G ++ + G T M A + GH ++V
Sbjct: 430 QVNM--PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487
Query: 219 ALM 221
AL+
Sbjct: 488 ALL 490
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/197 (31%), Positives = 88/197 (44%), Gaps = 2/197 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A S G YE+ + + ++ N G TPLM AS G+ IV LLL VN +
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A + G I LL +GA +E + G T L SAGH + R LLD GA
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + L A GH +V++ L G + + TA M A GH+++ L+
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 222 --DTYSPSLPKSLYRSP 236
++P + SP
Sbjct: 425 LDSGAQVNMPADSFESP 441
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/143 (33%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQG-WTA 138
G V LL+ G SVN T EG++ L LA S G +A LL A +E + +G T
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L +S G+ +V+ LL A+ N + G T L A A G IV+ LN G ++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
+ +G T M A GH+++ ++
Sbjct: 335 NENGHTPLMEAASAGHVEVARVL 357
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 35/172 (20%)
Query: 29 SGEELDVPLDLH----TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
SG ++++P D T A+ G + + + R +L + N G+TPLM A+ GH+ +
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486
Query: 85 VHLLLEAGVSVNVPTPEGQ-------------------------------TPLMLASSCG 113
V LLL G ++N T E Q TPLM AS G
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEG 546
Query: 114 NESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
+ + +LL GA + G TAL + GH + LL +GA+ + +E
Sbjct: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598
Score = 50.1 bits (118), Expect = 7e-06
Identities = 45/159 (28%), Positives = 70/159 (44%), Gaps = 10/159 (6%)
Query: 1 MSELSDEASEP------ELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKEC 54
+ E++DE P E +++ G ++ + + T A G + V +
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 55 VQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGN 114
+ + D+ G TPLM AS GH +V LL +G +V+ T G T L A G+
Sbjct: 524 LIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580
Query: 115 ESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
+A LLQ GA+L+ ++ T L A HQ V F
Sbjct: 581 TDVADVLLQAGADLDKQEDMK-TILEGIDPAKHQVRVAF 618
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 108 LASSC--GNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
LA +C G+ + LL +G + +G + L SAG+ + + LL AN R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPLM A++ G+ IV+ L H V+++ +G TA A G + IV ++
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 90.5 bits (223), Expect = 4e-18
Identities = 69/230 (30%), Positives = 99/230 (43%), Gaps = 32/230 (13%)
Query: 22 HGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGH 81
HG G E L A G ++V+ ++ D K T LM A GH
Sbjct: 349 HGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGA-DQEHKTDEMHTALMEACMDGH 406
Query: 82 DTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFH 141
+ LLL++G VN+P ++PL LA+ G+ +A L+++GA LE + +G+T L
Sbjct: 407 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 466
Query: 142 CTSAGHQHMVRFLLDSGANANVRE----------PICG--------------------FT 171
GH+ MV LL GAN N + CG T
Sbjct: 467 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 526
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
PLMEA+ GH +V+Y L G V A +G TA A + GH + ++
Sbjct: 527 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 4/183 (2%)
Query: 41 TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP 100
T A G + + + + ++ N G TPLM A+ GH + +LL+ G +N +
Sbjct: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358
Query: 101 E-GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGA 159
E ++ L LA G+ + FLL+ GA+ E K + TAL GH + R LLDSGA
Sbjct: 359 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 418
Query: 160 NANVREPICGF-TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
N+ P F +PL AA GH + + G ++ + G T M A + GH ++V
Sbjct: 419 QVNM--PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 476
Query: 219 ALM 221
AL+
Sbjct: 477 ALL 479
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/197 (31%), Positives = 88/197 (44%), Gaps = 2/197 (1%)
Query: 42 AASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPE 101
A S G YE+ + + ++ N G TPLM AS G+ IV LLL VN +
Sbjct: 234 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 293
Query: 102 GQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANA 161
G T L A + G I LL +GA +E + G T L SAGH + R LLD GA
Sbjct: 294 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 353
Query: 162 NVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
N + L A GH +V++ L G + + TA M A GH+++ L+
Sbjct: 354 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 413
Query: 222 --DTYSPSLPKSLYRSP 236
++P + SP
Sbjct: 414 LDSGAQVNMPADSFESP 430
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/143 (33%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQG-WTA 138
G V LL+ G SVN T EG++ L LA S G +A LL A +E + +G T
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 139 LFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
L +S G+ +V+ LL A+ N + G T L A A G IV+ LN G ++
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 323
Query: 199 DHSGATARMLAKQYGHMKIVALM 221
+ +G T M A GH+++ ++
Sbjct: 324 NENGHTPLMEAASAGHVEVARVL 346
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 35/172 (20%)
Query: 29 SGEELDVPLDLH----TAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
SG ++++P D T A+ G + + + R +L + N G+TPLM A+ GH+ +
Sbjct: 416 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 475
Query: 85 VHLLLEAGVSVNVPTPEGQ-------------------------------TPLMLASSCG 113
V LLL G ++N T E Q TPLM AS G
Sbjct: 476 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEG 535
Query: 114 NESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
+ + +LL GA + G TAL + GH + LL +GA+ + +E
Sbjct: 536 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
Score = 50.1 bits (118), Expect = 7e-06
Identities = 45/159 (28%), Positives = 70/159 (44%), Gaps = 10/159 (6%)
Query: 1 MSELSDEASEP------ELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKEC 54
+ E++DE P E +++ G ++ + + T A G + V +
Sbjct: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 512
Query: 55 VQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGN 114
+ + D+ G TPLM AS GH +V LL +G +V+ T G T L A G+
Sbjct: 513 LIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 569
Query: 115 ESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
+A LLQ GA+L+ ++ T L A HQ V F
Sbjct: 570 TDVADVLLQAGADLDKQEDMK-TILEGIDPAKHQVRVAF 607
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 2/116 (1%)
Query: 108 LASSC--GNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
LA +C G+ + LL +G + +G + L SAG+ + + LL AN R
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
TPLM A++ G+ IV+ L H V+++ +G TA A G + IV ++
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
>gi|118150656 ankyrin repeat domain 7 [Homo sapiens]
Length = 254
Score = 89.7 bits (221), Expect = 7e-18
Identities = 57/171 (33%), Positives = 91/171 (53%), Gaps = 1/171 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
LH AAS+G + +KE +Q ++ D+N ++ TPL A GH +V L+E +NV
Sbjct: 29 LHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIEQQCKINVR 88
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
E ++PL+ A C NE A LL GA+ +++DI+ T L + +V LL+
Sbjct: 89 DSENKSPLIKAVQCQNEDCATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVEKLLEYE 148
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLA 209
A+ + G+TPL+ A + +V++ L G V+A D+ TA +LA
Sbjct: 149 ADLEAKNK-DGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILA 198
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/86 (38%), Positives = 42/86 (48%)
Query: 43 ASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEG 102
A GQ + E + E DL KN G+TPL+ A + +V LLE G VN
Sbjct: 132 AVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQ 191
Query: 103 QTPLMLASSCGNESIAYFLLQQGAEL 128
+T L+LA S + LLQQG EL
Sbjct: 192 RTALILAVSGEPPCLVKLLLQQGVEL 217
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/88 (31%), Positives = 41/88 (46%)
Query: 71 TPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 130
T L YA ++V LLE + +G TPL++A N + FLL++GA++
Sbjct: 127 TVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNA 186
Query: 131 KDIQGWTALFHCTSAGHQHMVRFLLDSG 158
D TAL S +V+ LL G
Sbjct: 187 SDNYQRTALILAVSGEPPCLVKLLLQQG 214
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 89.7 bits (221), Expect = 7e-18
Identities = 62/164 (37%), Positives = 88/164 (53%), Gaps = 2/164 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G+ EV + +++ + + N G PL GH IV LLL G VN+
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAA-VAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+G+TPLM+A+S G+ FLL QGA + + D +G TAL GH +VR L+D+G
Sbjct: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSG 202
A A G TPL AA G +VQ+ ++HG ++ D+SG
Sbjct: 1157 A-ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSG 1199
Score = 77.4 bits (189), Expect = 4e-14
Identities = 62/192 (32%), Positives = 84/192 (43%), Gaps = 10/192 (5%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG---------GWTPLMYASYIGHDTIVHLLL 89
L AAS+G E+V + E D + G T L A+ G + LLL
Sbjct: 995 LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL 1054
Query: 90 EAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQH 149
E G +V P G PL G+ I LL GA++ M D QG T L S GH
Sbjct: 1055 EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG 1114
Query: 150 MVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLA 209
V FLL GA+ + + G T L A GH +V+ +++G D D +G T LA
Sbjct: 1115 TVDFLLAQGASIALMDKE-GLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLA 1173
Query: 210 KQYGHMKIVALM 221
YG ++V +
Sbjct: 1174 AFYGDAEVVQFL 1185
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/124 (32%), Positives = 64/124 (51%), Gaps = 6/124 (4%)
Query: 73 LMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKD 132
L S++G+ +V LLLE G +V+ + G TPL A++ G SI L ++ A+++ D
Sbjct: 889 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 948
Query: 133 IQGWTALFHCTSAGHQHMVRFLLD-----SGANANV-REPICGFTPLMEAAAAGHEIIVQ 186
G AL H GH +V+FL+ +G V ++ L+ AA+ G+ IV
Sbjct: 949 KNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVS 1008
Query: 187 YFLN 190
Y L+
Sbjct: 1009 YLLD 1012
Score = 53.5 bits (127), Expect = 6e-07
Identities = 51/182 (28%), Positives = 78/182 (42%), Gaps = 20/182 (10%)
Query: 61 DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF 120
+++ + G TPL YA+ G+ +IV LL + V+ GQ L+ A+ G+ + F
Sbjct: 910 NVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKF 969
Query: 121 LL---------QQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD---------SGANAN 162
L+ QQG + IQ AL S G+ +V +LLD A N
Sbjct: 970 LIQCDWTMAGQQQGVFKKSHAIQ--QALIAAASMGYTEIVSYLLDLPEKDEEEVERAQIN 1027
Query: 163 VREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMD 222
+ + G T L AA G + + L G V + GA + GH +IV L+
Sbjct: 1028 SFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLL 1087
Query: 223 TY 224
T+
Sbjct: 1088 TH 1089
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 5/143 (3%)
Query: 18 LSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECV-QRRELDLNKKNGGGWTPLMYA 76
L + HG ++ ++ PL + AAS G V + Q + L K G T L +A
Sbjct: 1085 LLLTHGADVNMADKQGRTPLMM--AASEGHLGTVDFLLAQGASIALMDKEG--LTALSWA 1140
Query: 77 SYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGW 136
GH ++V L++ G + + G+TPL LA+ G+ + FL+ GA +E D G
Sbjct: 1141 CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM 1200
Query: 137 TALFHCTSAGHQHMVRFLLDSGA 159
L + +V LL GA
Sbjct: 1201 RPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/110 (31%), Positives = 51/110 (46%), Gaps = 3/110 (2%)
Query: 114 NESIAYFLLQQGAELEMKDIQGWTALFHCTSA--GHQHMVRFLLDSGANANVREPICGFT 171
N ++ L+ GA + + A C + G+ MV LL+ GAN + G T
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSE-SGLT 920
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
PL AAAAG+ IV KVD D +G A + A GH+++V +
Sbjct: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
Score = 38.9 bits (89), Expect = 0.015
Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 46 GQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQT 104
G VV+ V D KNG TPL A++ G +V L++ G + G
Sbjct: 1144 GHLSVVRSLVDNGAATDHADKNGR--TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMR 1201
Query: 105 PLMLASSCGNESIAYFLLQQGAEL 128
PL A C N S+ LL++GA++
Sbjct: 1202 PLDRAVGCRNTSVVVTLLKKGAKI 1225
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 89.0 bits (219), Expect = 1e-17
Identities = 63/184 (34%), Positives = 95/184 (51%), Gaps = 2/184 (1%)
Query: 39 LHTAASIGQYEVV-KECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNV 97
+HTAAS GQ + + K V ++ ++LNK++ T L +A GH +V L++ +NV
Sbjct: 42 IHTAASRGQVQKLEKMTVGKKPVNLNKRDMKKRTALHWACVNGHAEVVTFLVDRKCQLNV 101
Query: 98 PTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDS 157
EG+TPLM A C E+ A L+ GA+L D+ G TAL + + + MV LL
Sbjct: 102 LDGEGRTPLMKALQCEREACANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSY 161
Query: 158 GANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
GA V+ TPL+ A + V++ L +A + S TA MLA G +I
Sbjct: 162 GAVIEVQNK-ASLTPLLLAIQKRSKQTVEFLLTKNANANAFNESKCTALMLAICEGSSEI 220
Query: 218 VALM 221
V ++
Sbjct: 221 VGML 224
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/131 (32%), Positives = 53/131 (40%), Gaps = 1/131 (0%)
Query: 61 DLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYF 120
DLN + G T L YA Y + +V LL G + V TPL+LA ++ F
Sbjct: 131 DLNYVDVYGNTALHYAVYSENLLMVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTVEF 190
Query: 121 LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAG 180
LL + A + TAL G +V LL + E I G T AAA G
Sbjct: 191 LLTKNANANAFNESKCTALMLAICEGSSEIVGMLLQQNVDV-FAEDIHGITAERYAAACG 249
Query: 181 HEIIVQYFLNH 191
I Q L H
Sbjct: 250 VNYIHQQLLEH 260
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 88.6 bits (218), Expect = 2e-17
Identities = 66/194 (34%), Positives = 96/194 (49%), Gaps = 2/194 (1%)
Query: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
G VS + D L LH AA G +VK ++ + +N + G TPL A+ GH +
Sbjct: 560 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
Query: 85 VHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTS 144
+L++ VNV + QTPL +A+ G+ S A LL +GA E G+TAL
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679
Query: 145 AGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGAT 204
GH V+ L++ A+ R P+ T L AAA GH +V+ ++ V +D D G +
Sbjct: 680 NGHLATVKLLVEEKADVLARGPL-NQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLS 737
Query: 205 ARMLAKQYGHMKIV 218
A LA Q H + V
Sbjct: 738 ALHLAAQGRHAQTV 751
Score = 78.2 bits (191), Expect = 2e-14
Identities = 57/205 (27%), Positives = 87/205 (42%), Gaps = 35/205 (17%)
Query: 51 VKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLAS 110
V E + R++ +N K+ WT L +A+ G ++ LLLE SVN EG+TP+ +A
Sbjct: 486 VVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVAC 545
Query: 111 SCGNESIAYFLLQQGAELEMKDIQGW---------------------------------- 136
G E+I LL++G ++ ++ W
Sbjct: 546 QHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR 605
Query: 137 TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVD 196
T L GH + R L+D ++ NV + TPL AA GH + L+ G +
Sbjct: 606 TPLHLAAQRGHYRVARILIDLCSDVNVCS-LLAQTPLHVAAETGHTSTARLLLHRGAGKE 664
Query: 197 ARDHSGATARMLAKQYGHMKIVALM 221
A G TA LA + GH+ V L+
Sbjct: 665 AMTSDGYTALHLAARNGHLATVKLL 689
Score = 58.2 bits (139), Expect = 2e-08
Identities = 48/176 (27%), Positives = 70/176 (39%), Gaps = 3/176 (1%)
Query: 46 GQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTP 105
G + + +Q +++DL +G L A G + LL + N+ G TP
Sbjct: 417 GDTSKLMKILQPQDVDLALDSGASLLHL--AVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
Query: 106 LMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE 165
L +A + LL + + KD WTAL G + R LL+ A+ N
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVN-EV 533
Query: 166 PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G TP+ A G E IV+ L GV V + A GH+ IV L+
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/164 (37%), Positives = 87/164 (53%), Gaps = 2/164 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G+ EV E + +++ N G PL A+ GH IV LLLE G VN+
Sbjct: 1075 LTAAAGRGKLEVC-ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+G+TPLM+A+ G+ S FLL +GA L D +G +AL GH+ +V++L++ G
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSG 202
A + + G TPL AA G V Y + G ++ DHSG
Sbjct: 1194 AAIDQTDK-NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
Score = 77.4 bits (189), Expect = 4e-14
Identities = 60/185 (32%), Positives = 84/185 (45%), Gaps = 7/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG-----GWTPLMYASYIGHDTIVHLLLEAGV 93
L AAS+G VV +C+ E + + G G T L A+ G + LLL G
Sbjct: 1037 LTAAASMGHSSVV-QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGA 1095
Query: 94 SVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
+V+ G PL A+ G+ I LL++G ++ + D QG T L GH V F
Sbjct: 1096 AVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1155
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL GA + + G + L A GH +VQY + G +D D +G T LA YG
Sbjct: 1156 LLSKGAALSSLDKE-GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG 1214
Query: 214 HMKIV 218
+ V
Sbjct: 1215 DAETV 1219
Score = 60.1 bits (144), Expect = 6e-09
Identities = 45/160 (28%), Positives = 76/160 (47%), Gaps = 11/160 (6%)
Query: 73 LMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKD 132
L S++GH+ +V LLLE G ++ + G T L A++ G+ + L ++G ++ D
Sbjct: 931 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 990
Query: 133 IQGWTALFHCTSAGHQHMVRFLLDSGAN------ANVREPICGFTPLMEAAAAGHEIIVQ 186
+G AL H GH ++++LL + +R+ L AA+ GH +VQ
Sbjct: 991 KKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQ 1050
Query: 187 YFL----NHGVKVDARDHS-GATARMLAKQYGHMKIVALM 221
L H V+V+ D G TA A G +++ L+
Sbjct: 1051 CLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1090
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/173 (28%), Positives = 75/173 (43%), Gaps = 15/173 (8%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFL 121
L+ + G T L YA+ GH +V LL + GV V+ +GQ L+ ++ G+ I +L
Sbjct: 953 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1012
Query: 122 L---------QQGAELEMKDIQGWTALFHCTSAGHQHMVRFLL----DSGANANVREPIC 168
L Q G + +Q AL S GH +V+ LL + N + +
Sbjct: 1013 LTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLW 1070
Query: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G T L AA G + + L HG V + G A + GH +IV L+
Sbjct: 1071 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLL 1123
Score = 54.7 bits (130), Expect = 3e-07
Identities = 60/200 (30%), Positives = 81/200 (40%), Gaps = 22/200 (11%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEG-------QTPLMLASSCGN 114
L+KK G L++++ GH I+ LL S P P Q L A+S G+
Sbjct: 989 LDKK---GQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGH 1045
Query: 115 ESIAYFLLQQGAELEMK-----DIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICG 169
S+ LL E E++ + G TAL G + LL GA + R G
Sbjct: 1046 SSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS-RTNRRG 1104
Query: 170 FTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLP 229
PL AA GH IV+ L G V+ D G T M+A GH+ V + L
Sbjct: 1105 VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL------LS 1158
Query: 230 KSLYRSPEKYEDLSSSDESC 249
K S E LS+ +C
Sbjct: 1159 KGAALSSLDKEGLSALSWAC 1178
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G V E + + L+ + G + L +A GH +V L+E G +++
Sbjct: 1141 LMVAACEGHLSTV-EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1199
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G+TPL LA+ G+ +L+++GA +E D G L + +V LL G
Sbjct: 1200 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259
Query: 159 A 159
A
Sbjct: 1260 A 1260
Score = 41.6 bits (96), Expect = 0.002
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 5/121 (4%)
Query: 114 NESIAYFLLQQGAELEMKDIQGWTALFHCTSA--GHQHMVRFLLDSGANANVREPICGFT 171
N ++ L+ GA + + A C + GH+ +V LL+ GA + G T
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSEN-GMT 962
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDT--YSPSLP 229
L AAAAGH +V GV+VD D G A + + GH I+ + T +SP P
Sbjct: 963 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
Query: 230 K 230
+
Sbjct: 1023 Q 1023
Score = 39.3 bits (90), Expect = 0.012
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 46 GQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQT 104
G VV+ V+ +D KNG TPL A++ G V L+E G + G
Sbjct: 1181 GHRAVVQYLVEEGAAIDQTDKNGR--TPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1238
Query: 105 PLMLASSCGNESIAYFLLQQGAEL 128
PL A C N S+ LL++GA+L
Sbjct: 1239 PLDRAIGCRNTSVVVALLRKGAKL 1262
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 86.3 bits (212), Expect = 8e-17
Identities = 61/164 (37%), Positives = 87/164 (53%), Gaps = 2/164 (1%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G+ EV E + +++ N G PL A+ GH IV LLLE G VN+
Sbjct: 1083 LTAAAGRGKLEVC-ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
+G+TPLM+A+ G+ S FLL +GA L D +G +AL GH+ +V++L++ G
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201
Query: 159 ANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSG 202
A + + G TPL AA G V Y + G ++ DHSG
Sbjct: 1202 AAIDQTDK-NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
Score = 77.4 bits (189), Expect = 4e-14
Identities = 60/185 (32%), Positives = 84/185 (45%), Gaps = 7/185 (3%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGG-----GWTPLMYASYIGHDTIVHLLLEAGV 93
L AAS+G VV +C+ E + + G G T L A+ G + LLL G
Sbjct: 1045 LTAAASMGHSSVV-QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGA 1103
Query: 94 SVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRF 153
+V+ G PL A+ G+ I LL++G ++ + D QG T L GH V F
Sbjct: 1104 AVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1163
Query: 154 LLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYG 213
LL GA + + G + L A GH +VQY + G +D D +G T LA YG
Sbjct: 1164 LLSKGAALSSLDKE-GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG 1222
Query: 214 HMKIV 218
+ V
Sbjct: 1223 DAETV 1227
Score = 60.1 bits (144), Expect = 6e-09
Identities = 45/160 (28%), Positives = 76/160 (47%), Gaps = 11/160 (6%)
Query: 73 LMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKD 132
L S++GH+ +V LLLE G ++ + G T L A++ G+ + L ++G ++ D
Sbjct: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 998
Query: 133 IQGWTALFHCTSAGHQHMVRFLLDSGAN------ANVREPICGFTPLMEAAAAGHEIIVQ 186
+G AL H GH ++++LL + +R+ L AA+ GH +VQ
Sbjct: 999 KKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQ 1058
Query: 187 YFL----NHGVKVDARDHS-GATARMLAKQYGHMKIVALM 221
L H V+V+ D G TA A G +++ L+
Sbjct: 1059 CLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1098
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/173 (28%), Positives = 75/173 (43%), Gaps = 15/173 (8%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFL 121
L+ + G T L YA+ GH +V LL + GV V+ +GQ L+ ++ G+ I +L
Sbjct: 961 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1020
Query: 122 L---------QQGAELEMKDIQGWTALFHCTSAGHQHMVRFLL----DSGANANVREPIC 168
L Q G + +Q AL S GH +V+ LL + N + +
Sbjct: 1021 LTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLW 1078
Query: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
G T L AA G + + L HG V + G A + GH +IV L+
Sbjct: 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLL 1131
Score = 54.7 bits (130), Expect = 3e-07
Identities = 60/200 (30%), Positives = 81/200 (40%), Gaps = 22/200 (11%)
Query: 62 LNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEG-------QTPLMLASSCGN 114
L+KK G L++++ GH I+ LL S P P Q L A+S G+
Sbjct: 997 LDKK---GQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGH 1053
Query: 115 ESIAYFLLQQGAELEMK-----DIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICG 169
S+ LL E E++ + G TAL G + LL GA + R G
Sbjct: 1054 SSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS-RTNRRG 1112
Query: 170 FTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLP 229
PL AA GH IV+ L G V+ D G T M+A GH+ V + L
Sbjct: 1113 VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL------LS 1166
Query: 230 KSLYRSPEKYEDLSSSDESC 249
K S E LS+ +C
Sbjct: 1167 KGAALSSLDKEGLSALSWAC 1186
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Query: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
L AA G V E + + L+ + G + L +A GH +V L+E G +++
Sbjct: 1149 LMVAACEGHLSTV-EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1207
Query: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
G+TPL LA+ G+ +L+++GA +E D G L + +V LL G
Sbjct: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267
Query: 159 A 159
A
Sbjct: 1268 A 1268
Score = 41.6 bits (96), Expect = 0.002
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 5/121 (4%)
Query: 114 NESIAYFLLQQGAELEMKDIQGWTALFHCTSA--GHQHMVRFLLDSGANANVREPICGFT 171
N ++ L+ GA + + A C + GH+ +V LL+ GA + G T
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSEN-GMT 970
Query: 172 PLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDT--YSPSLP 229
L AAAAGH +V GV+VD D G A + + GH I+ + T +SP P
Sbjct: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
Query: 230 K 230
+
Sbjct: 1031 Q 1031
Score = 39.3 bits (90), Expect = 0.012
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 46 GQYEVVKECVQR-RELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQT 104
G VV+ V+ +D KNG TPL A++ G V L+E G + G
Sbjct: 1189 GHRAVVQYLVEEGAAIDQTDKNGR--TPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1246
Query: 105 PLMLASSCGNESIAYFLLQQGAEL 128
PL A C N S+ LL++GA+L
Sbjct: 1247 PLDRAIGCRNTSVVVALLRKGAKL 1270
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 85.1 bits (209), Expect = 2e-16
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 43 ASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEG 102
A+ G +E + + RR +N +N GW+ LM A+ GH ++ HLLL+ G VN G
Sbjct: 85 AAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLG 144
Query: 103 QTPLMLASSCGNESIAYFLLQQGAELEMKDIQG--------------WTALFHCTSAGHQ 148
+ L +AS G+ + LL+ GA ++ G TAL GH+
Sbjct: 145 ASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHE 204
Query: 149 HMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARML 208
+VR L++ GA+ N G++PLM AA G + Q + G D TA +
Sbjct: 205 AVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEV 264
Query: 209 AKQYGHMKIVALMDTYSPSLPKS 231
A H +V +D + PK+
Sbjct: 265 ALDCKHRDLVDYLDPLTTVRPKT 287
Score = 70.1 bits (170), Expect = 6e-12
Identities = 47/145 (32%), Positives = 69/145 (47%), Gaps = 15/145 (10%)
Query: 91 AGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHM 150
A V V+ G T L A++ G+E + FLL++GA + ++ GW+AL GH +
Sbjct: 67 APVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSV 126
Query: 151 VRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSG-------- 202
LLD GA+ N + + G + L A+ GH +V+ L G VD SG
Sbjct: 127 AHLLLDHGADVNAQNRL-GASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGS 185
Query: 203 ------ATARMLAKQYGHMKIVALM 221
TA M A Q+GH +V L+
Sbjct: 186 RDEPLDITALMAAIQHGHEAVVRLL 210
Score = 65.9 bits (159), Expect = 1e-10
Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 69 GWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAEL 128
G T L +A+ GH+ +V LL G SVN G + LM A+ G+ S+A+ LL GA++
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 129 EMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPI-------------CGFTPLME 175
++ G + L + GH +V+ LL++GA + P T LM
Sbjct: 138 NAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
Query: 176 AAAAGHEIIVQYFLNHGVKVD-ARDHSGATARMLAKQYGHMKI 217
A GHE +V+ + G + A G + MLA G + +
Sbjct: 198 AIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV 240
Score = 62.4 bits (150), Expect = 1e-09
Identities = 37/102 (36%), Positives = 56/102 (54%), Gaps = 1/102 (0%)
Query: 38 DLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN- 96
D+ A +G +++VKE +N NG G TPLM A+ G +V LL+E V+
Sbjct: 295 DIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDK 354
Query: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTA 138
+ G T LM A+ GN+ I +LL QGA++ ++ G+TA
Sbjct: 355 QDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTA 396
Score = 60.5 bits (145), Expect = 5e-09
Identities = 51/187 (27%), Positives = 84/187 (44%), Gaps = 12/187 (6%)
Query: 304 GENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARAQGL 363
G L G +V S I + +++ + H + +GP SS SE A G
Sbjct: 650 GGELLNRSGGSIDNVLSQIAAQRKKAAGLLEQKPSHR-SSPVGPAPGSSPSELPASPAGG 708
Query: 364 SSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQRAP 423
S A V ++ S +KS T P P+ T + SS + ++
Sbjct: 709 S--APVGKKLETSKRPPSGTSTTSKSTSPTLTPSPS--PKGHTAESSVSSSSSHRQSKSS 764
Query: 424 -------YSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKR 476
+ +L +L+++ KY +FEEQ+VD+ FLTLT+ DLKE+GI G ++
Sbjct: 765 GGSSSGTITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQ 824
Query: 477 KMTSAIA 483
++ +AI+
Sbjct: 825 QILAAIS 831
Score = 56.2 bits (134), Expect = 9e-08
Identities = 30/94 (31%), Positives = 58/94 (61%), Gaps = 2/94 (2%)
Query: 73 LMYASYIGHDTIVHLLLEAGVS-VNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMK 131
+ +A +G+ +V + + S VN+ +G TPLMLA+ G ++ L+++ A+++ +
Sbjct: 296 IFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQ 355
Query: 132 D-IQGWTALFHCTSAGHQHMVRFLLDSGANANVR 164
D + GWTAL T G++ +V++LL+ GA+ +R
Sbjct: 356 DSVHGWTALMQATYHGNKEIVKYLLNQGADVTLR 389
Score = 52.8 bits (125), Expect = 1e-06
Identities = 64/269 (23%), Positives = 103/269 (38%), Gaps = 54/269 (20%)
Query: 22 HGLGTQVS-GEELDVPLD---LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYAS 77
H G Q+ G D PLD L A G VV+ ++ + GW+PLM A+
Sbjct: 174 HPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAA 233
Query: 78 YIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFL---------------- 121
G + L+E G + + + +T +A C + + +L
Sbjct: 234 LTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRR 293
Query: 122 ------LQQGAELEMKDI-------------QGWTALFHCTSAGHQHMVRFLLDSGANAN 162
L+ G +K+I G T L G +V+ L++ A+ +
Sbjct: 294 PDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
Query: 163 VREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATA---------------RM 207
++ + G+T LM+A G++ IV+Y LN G V R +G TA R+
Sbjct: 354 KQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRL 413
Query: 208 LAKQYGHMKIVALMDTYSPSLPKSLYRSP 236
LA + ++ P LP S R P
Sbjct: 414 LASVCMQVNKDKGRPSHQPPLPHSKVRQP 442
>gi|153791352 prostate, ovary, testis expressed protein on
chromosome 2 [Homo sapiens]
Length = 1075
Score = 84.0 bits (206), Expect = 4e-16
Identities = 112/426 (26%), Positives = 162/426 (38%), Gaps = 35/426 (8%)
Query: 26 TQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIV 85
T V+ ++ LH A++ G EVVK + RR LN + T L+ A D
Sbjct: 164 TDVNKQDKQKRTALHLASANGNSEVVKLLLDRR-CQLNVLDNKKRTALIKAVQCQEDECA 222
Query: 86 HLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSA 145
+LLE G N+P G T L A ++ +A LL GA++E K+ G T L
Sbjct: 223 LMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHE 282
Query: 146 GHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATA 205
Q +V+FL+ AN N + G T L+ A G IV L + V ++D SG TA
Sbjct: 283 QKQQVVKFLIKKKANLNALDRY-GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 341
Query: 206 RMLAKQYGHMKIVALMDTYSP----------SLPKSLYR--SPEKYEDLSSSDESCPAPQ 253
R A H I L+ Y S P+ + S E+ + S+ S P
Sbjct: 342 REYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKM 401
Query: 254 RQRP-CRKKG-------VSIHEGPRA--LARITG---IGLGGRAPRPRYEQAPPRGYVTF 300
Q P K G + HE L +T G G P+ + P
Sbjct: 402 SQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPEN---- 457
Query: 301 NSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARA 360
+N EE C ++ S E+ + SS +S E L + S +G
Sbjct: 458 QQFPDNESEEYHRIC-ELLSDYKEKQMPKYSSENSNPEQDL--KLTSEEESQRLKGSENG 514
Query: 361 QGLSSEASVESNEDSDHACKS-SARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQT 419
Q E N+D D ++ A ++ K + T + AT G P+
Sbjct: 515 QPEKRSQEPEINKDGDRELENFMAIEEMKKHRSTHVGFPENLTNGATAGNGDDGLIPPRK 574
Query: 420 QRAPYS 425
R P S
Sbjct: 575 SRTPES 580
>gi|134133226 protein expressed in prostate, ovary, testis, and
placenta 2 [Homo sapiens]
Length = 1075
Score = 82.4 bits (202), Expect = 1e-15
Identities = 72/226 (31%), Positives = 101/226 (44%), Gaps = 5/226 (2%)
Query: 26 TQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIV 85
T V+ ++ LH A++ G EVVK + RR LN + T L+ A D
Sbjct: 164 TDVNKKDKQKRTALHLASANGNSEVVKLLLDRR-CQLNVLDNKKRTALIKAVQCQEDECA 222
Query: 86 HLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSA 145
+LLE G N+P G T L A ++ +A LL GA++E K+ G T L
Sbjct: 223 LMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHE 282
Query: 146 GHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATA 205
Q +V+FL+ AN N + G T L+ A G IV L + V ++D SG TA
Sbjct: 283 QKQQVVKFLIKKKANLNALDRY-GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 341
Query: 206 RMLAKQYGHMKIVALMDTYSPSLP---KSLYRSPEKYEDLSSSDES 248
R A H I L+ Y S +PE+ L+S +ES
Sbjct: 342 REYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQELKLTSEEES 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,062,466
Number of Sequences: 37866
Number of extensions: 1221544
Number of successful extensions: 7372
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 369
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 3859
Number of HSP's gapped (non-prelim): 1910
length of query: 656
length of database: 18,247,518
effective HSP length: 109
effective length of query: 547
effective length of database: 14,120,124
effective search space: 7723707828
effective search space used: 7723707828
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.