Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 42718011
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo
sapiens]
(664 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 1342 0.0
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 832 0.0
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 825 0.0
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 791 0.0
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 791 0.0
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 593 e-169
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 302 7e-82
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 294 2e-79
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 177 2e-44
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 171 2e-42
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 167 3e-41
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 164 2e-40
gi|27886653 potassium voltage-gated channel, subfamily H, member... 154 3e-37
gi|22024390 potassium voltage-gated channel, subfamily H, member... 152 1e-36
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 150 3e-36
gi|27886648 potassium voltage-gated channel, subfamily H, member... 150 4e-36
gi|13540549 potassium voltage-gated channel, subfamily H, member... 149 6e-36
gi|27437001 potassium voltage-gated channel, subfamily H, member... 143 4e-34
gi|27886667 potassium voltage-gated channel, subfamily H, member... 140 3e-33
gi|26051273 voltage-gated potassium channel, subfamily H, member... 140 5e-33
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 140 5e-33
gi|27886646 potassium voltage-gated channel, subfamily H, member... 134 3e-31
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 131 2e-30
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 130 5e-30
gi|27886651 potassium voltage-gated channel, subfamily H, member... 126 7e-29
gi|26051271 voltage-gated potassium channel, subfamily H, member... 121 2e-27
gi|27886665 potassium voltage-gated channel, subfamily H, member... 88 2e-17
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 45 2e-04
gi|116256487 patatin-like phospholipase domain containing 6 [Hom... 42 0.001
gi|18201890 hypothetical protein LOC140894 [Homo sapiens] 39 0.012
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 1342 bits (3474), Expect = 0.0
Identities = 664/664 (100%), Positives = 664/664 (100%)
Query: 1 MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ 60
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
Sbjct: 1 MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ 60
Query: 61 QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE 120
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
Sbjct: 61 QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE 120
Query: 121 DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY 180
DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
Sbjct: 121 DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY 180
Query: 181 VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI 240
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
Sbjct: 181 VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI 240
Query: 241 HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI 300
HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
Sbjct: 241 HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI 300
Query: 301 GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG 360
GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
Sbjct: 301 GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG 360
Query: 361 VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK 420
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
Sbjct: 361 VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK 420
Query: 421 KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY 480
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
Sbjct: 421 KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY 480
Query: 481 ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI 540
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
Sbjct: 481 ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI 540
Query: 541 RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK 600
RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
Sbjct: 541 RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK 600
Query: 601 LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA 660
LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
Sbjct: 601 LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA 660
Query: 661 ADEP 664
ADEP
Sbjct: 661 ADEP 664
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 832 bits (2150), Expect = 0.0
Identities = 421/666 (63%), Positives = 517/666 (77%), Gaps = 23/666 (3%)
Query: 4 KTNGVKSSPANNHNHHAPPAIKANGKDDHRTS---SRPHSAADDDTS-------SELQRL 53
K N S P+ H +K + +D +R SR HS++++ +S E + L
Sbjct: 3 KINTQYSHPSRTHLK-----VKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGL 57
Query: 54 ADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDG 113
AD G R+ RL+ ++R WA ++ ++ PDSF +RFRG EL+ V++QE +
Sbjct: 58 ADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
Query: 114 K---GDKDGEDKGTKKKF---ELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDL 167
+ G ++ D+G +KK + V+DP+ + YY WL IA+PV YNW LL+ RACF +L
Sbjct: 118 QANVGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDEL 177
Query: 168 QKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVAS 227
Q Y ++WLVLDY +DV+Y+ D+ +R RTGFLEQGL+V DT +L +Y T QFKLDV S
Sbjct: 178 QSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLS 237
Query: 228 IIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIH 287
++PTDL Y V + PEVRFNRLL F+R+FEFFDRTETRTNYPN+FRI NLVLYIL+IIH
Sbjct: 238 LVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIH 297
Query: 288 WNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKD 347
WNACIY+AISK IGFG D+WVYPNI+ PE+G L+R+YIY LYWSTLTLTTIGETPPPVKD
Sbjct: 298 WNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKD 357
Query: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407
EEYLFV+ DFL+GVLIFATIVGNVGSMISNMNA+RAEFQAKID++K YMQFRKV+K +E
Sbjct: 358 EEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLET 417
Query: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467
+VIRWFDYLW NKKTVDE+E+LK+LP KL+AEIAINVHL TLKKVRIF DCEAGLLVELV
Sbjct: 418 RVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELV 477
Query: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527
LKLRP VFSPGDYIC+KGDIGKEMYII EGKLAVVADDGVTQ+ +LS GS FGEISILNI
Sbjct: 478 LKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNI 537
Query: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDEN 587
KGSK GNRRTANIRS+GYSDLFCLSKDDLMEA+TEYP+AKK LEE+GR+ILMK+ L+DE
Sbjct: 538 KGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 597
Query: 588 EVATSME-VDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNED 646
+ D++EK+ QL ++++TL TRF RLLAEY Q K+KQR++ LE+++K D
Sbjct: 598 LARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVK-GGGD 656
Query: 647 DYLSDG 652
L+DG
Sbjct: 657 KPLADG 662
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 825 bits (2130), Expect = 0.0
Identities = 423/685 (61%), Positives = 518/685 (75%), Gaps = 43/685 (6%)
Query: 4 KTNGVKSSPANNHNHHAPPAIKANGKDDHRTS---SRPHSAADDDTS-------SELQRL 53
K N S P+ H +K + +D +R SR HS++++ +S E + L
Sbjct: 3 KINTQYSHPSRTHLK-----VKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGL 57
Query: 54 ADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDG 113
AD G R+ RL+ ++R WA ++ ++ PDSF +RFRG EL+ V++QE +
Sbjct: 58 ADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
Query: 114 K---GDKDGEDKG----------------------TKKKFELFVLDPAGDWYYCWLFVIA 148
+ G ++ D+G TKKK + V+DP+ + YY WL IA
Sbjct: 118 QANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKK-DAIVVDPSSNLYYRWLTAIA 176
Query: 149 MPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDT 208
+PV YNW LL+ RACF +LQ Y ++WLVLDY +DV+Y+ D+ +R RTGFLEQGL+V DT
Sbjct: 177 LPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDT 236
Query: 209 KKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTN 268
+L +Y T QFKLDV S++PTDL Y V + PEVRFNRLL F+R+FEFFDRTETRTN
Sbjct: 237 NRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTN 296
Query: 269 YPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCL 328
YPN+FRI NLVLYIL+IIHWNACIY+AISK IGFG D+WVYPNI+ PE+G L+R+YIY L
Sbjct: 297 YPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSL 356
Query: 329 YWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAK 388
YWSTLTLTTIGETPPPVKDEEYLFV+ DFL+GVLIFATIVGNVGSMISNMNA+RAEFQAK
Sbjct: 357 YWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416
Query: 389 IDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLST 448
ID++K YMQFRKV+K +E +VIRWFDYLW NKKTVDE+E+LK+LP KL+AEIAINVHL T
Sbjct: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476
Query: 449 LKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVT 508
LKKVRIF DCEAGLLVELVLKLRP VFSPGDYIC+KGDIGKEMYII EGKLAVVADDGVT
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536
Query: 509 QYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKK 568
Q+ +LS GS FGEISILNIKGSK GNRRTANIRS+GYSDLFCLSKDDLMEA+TEYP+AKK
Sbjct: 537 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 596
Query: 569 VLEERGREILMKEGLLDENEVATSME-VDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQ 627
LEE+GR+ILMK+ L+DE + D++EK+ QL ++++TL TRF RLLAEY Q
Sbjct: 597 ALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQM 656
Query: 628 KLKQRITVLETKMKQNNEDDYLSDG 652
K+KQR++ LE+++K D L+DG
Sbjct: 657 KMKQRLSQLESQVK-GGGDKPLADG 680
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 791 bits (2043), Expect = 0.0
Identities = 386/574 (67%), Positives = 471/574 (82%), Gaps = 1/574 (0%)
Query: 78 EWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAG 137
E K +E++ + D E PE + + K ++ +DK ++K E+ V+DP+G
Sbjct: 172 EEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSG 231
Query: 138 DWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTG 197
+ YY WLF I +PV+YNW +++ARACF +LQ Y WL+LDYVSD+VY+ D+F+R RTG
Sbjct: 232 NTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTG 291
Query: 198 FLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMF 257
+LEQGLLVK+ KL + Y LQFKLDV S+IPTDL+YF + + PE+R NRLL F+RMF
Sbjct: 292 YLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMF 351
Query: 258 EFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEY 317
EFF RTETRTNYPNIFRISNLV+YI++IIHWNAC++Y+ISK+IGFG DTWVYP+I DPE+
Sbjct: 352 EFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEF 411
Query: 318 GYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISN 377
G LAR+Y+Y LYWSTLTLTTIGETPPPV+D EY+FV+ DFLIGVLIFATIVGN+GSMISN
Sbjct: 412 GRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISN 471
Query: 378 MNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLR 437
MNA RAEFQA+IDA+K YM FR VSK ME +VI+WFDYLWTNKKTVDE+E+LK LP KLR
Sbjct: 472 MNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLR 531
Query: 438 AEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEG 497
AEIAINVHL TLKKVRIF DCEAGLLVELVLKL+PQV+SPGDYIC+KGDIG+EMYIIKEG
Sbjct: 532 AEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEG 591
Query: 498 KLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLM 557
KLAVVADDGVTQ+ +LS GS FGEISILNIKGSK GNRRTANI+S+GYSDLFCLSKDDLM
Sbjct: 592 KLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLM 651
Query: 558 EAVTEYPDAKKVLEERGREILMKEGLLDENEV-ATSMEVDVQEKLGQLETNMETLYTRFG 616
EA+TEYPDAK +LEE+G++ILMK+GLLD N A S D++EK+ ++E +++ L TRF
Sbjct: 652 EALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFA 711
Query: 617 RLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLS 650
R+LAEY QQKLKQR+T +E +K + ++ S
Sbjct: 712 RILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSS 745
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 791 bits (2043), Expect = 0.0
Identities = 386/574 (67%), Positives = 471/574 (82%), Gaps = 1/574 (0%)
Query: 78 EWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAG 137
E K +E++ + D E PE + + K ++ +DK ++K E+ V+DP+G
Sbjct: 103 EEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSG 162
Query: 138 DWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTG 197
+ YY WLF I +PV+YNW +++ARACF +LQ Y WL+LDYVSD+VY+ D+F+R RTG
Sbjct: 163 NTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTG 222
Query: 198 FLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMF 257
+LEQGLLVK+ KL + Y LQFKLDV S+IPTDL+YF + + PE+R NRLL F+RMF
Sbjct: 223 YLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMF 282
Query: 258 EFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEY 317
EFF RTETRTNYPNIFRISNLV+YI++IIHWNAC++Y+ISK+IGFG DTWVYP+I DPE+
Sbjct: 283 EFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEF 342
Query: 318 GYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISN 377
G LAR+Y+Y LYWSTLTLTTIGETPPPV+D EY+FV+ DFLIGVLIFATIVGN+GSMISN
Sbjct: 343 GRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISN 402
Query: 378 MNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLR 437
MNA RAEFQA+IDA+K YM FR VSK ME +VI+WFDYLWTNKKTVDE+E+LK LP KLR
Sbjct: 403 MNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLR 462
Query: 438 AEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEG 497
AEIAINVHL TLKKVRIF DCEAGLLVELVLKL+PQV+SPGDYIC+KGDIG+EMYIIKEG
Sbjct: 463 AEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEG 522
Query: 498 KLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLM 557
KLAVVADDGVTQ+ +LS GS FGEISILNIKGSK GNRRTANI+S+GYSDLFCLSKDDLM
Sbjct: 523 KLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLM 582
Query: 558 EAVTEYPDAKKVLEERGREILMKEGLLDENEV-ATSMEVDVQEKLGQLETNMETLYTRFG 616
EA+TEYPDAK +LEE+G++ILMK+GLLD N A S D++EK+ ++E +++ L TRF
Sbjct: 583 EALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFA 642
Query: 617 RLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLS 650
R+LAEY QQKLKQR+T +E +K + ++ S
Sbjct: 643 RILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSS 676
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 593 bits (1528), Expect = e-169
Identities = 291/540 (53%), Positives = 395/540 (73%), Gaps = 8/540 (1%)
Query: 124 TKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSD 183
+K + L VLDP+GD+YY WL + PV+YN +LV RACF DLQ GY + WLVLDY SD
Sbjct: 18 SKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSD 77
Query: 184 VVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSP 243
++Y+ D+ +R TGFLEQG+LV D ++ Y+ T F LD+AS++PTD++Y + H+P
Sbjct: 78 LLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTP 137
Query: 244 EVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFG 303
+R NR L R+FE FDRTETRT YPN FRI+ L+LYI V+IHWN+C+Y+A+S+ +GFG
Sbjct: 138 TLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFG 197
Query: 304 VDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLI 363
D WVYP+ P + L R+Y+Y Y+STL LTT+G+TPPP ++EEYLF++ DFL+ V+
Sbjct: 198 RDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMG 257
Query: 364 FATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTV 423
FATI+G++ S+I NMN A F VK YM+ + V++ +E +VI W+ +L NKK
Sbjct: 258 FATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMT 317
Query: 424 DEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICR 483
+E IL++LP +LRAE+A++VHLSTL +V+IF +CEA LL ELVLKL+PQ +SPG+Y+CR
Sbjct: 318 NEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCR 377
Query: 484 KGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSL 543
KGDIG+EMYII+EG+LAVVADDG+TQYA+L AG FGEISI+NIKG+ GNRRTANI+SL
Sbjct: 378 KGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSL 437
Query: 544 GYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQE---- 599
GYSDLFCLSK+DL E ++EYP A+ ++EE+GREIL+K LD N A + E+ +QE
Sbjct: 438 GYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVN--AEAAEIALQEATES 495
Query: 600 KLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQ--NNEDDYLSDGMNSPE 657
+L L+ ++ L T+F RLLAE + K+ RI LE + ++ ED +D PE
Sbjct: 496 RLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPE 555
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 302 bits (773), Expect = 7e-82
Identities = 188/614 (30%), Positives = 311/614 (50%), Gaps = 49/614 (7%)
Query: 3 EKTNGVKSSPANNHNHHA---PPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAP 59
EK+ KS+P + H K N D T+ P +AA+ + Q+ ++D
Sbjct: 50 EKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQK--EMDPG 107
Query: 60 QQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFR---------GPELQTVTTQE 110
++G + + +I E+A+ R ++ PE T +
Sbjct: 108 KEGPNSPQNKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKP 167
Query: 111 GDGKGDKDGEDKGTKKKFELF--------------------VLDPAGD-WYYCWLFVIAM 149
K+ +DK T+ + L +D D Y WL ++ +
Sbjct: 168 TAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTL 227
Query: 150 PVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIAD-LFIRLRTGFLEQGLLVKDT 208
+N C + R F WL+ D + D++Y+ D LFI+ R F+ G ++ D+
Sbjct: 228 AYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDS 287
Query: 209 KKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTN 268
+LR +Y + +F+LDVASIIP D+ Y + P R NR+L + FEF E+ +
Sbjct: 288 NELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYTSFFEFNHHLESIMD 346
Query: 269 YPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCL 328
I+R+ Y+L I+H NAC+YY S G G WVY D E EY+ C
Sbjct: 347 KAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVY----DGE----GNEYLRCY 398
Query: 329 YWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAK 388
YW+ TL TIG P P E +F + +F GV +F++++G + +I A + F+A
Sbjct: 399 YWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRAC 458
Query: 389 IDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLST 448
+D YM + K ++ +V W++Y W +++ +DE ++LK LP ++ +AI+V+ S
Sbjct: 459 MDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSI 518
Query: 449 LKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVV-ADDGV 507
+ KV +F C+ ++ +++L+L+ ++ PGD++C+KG+IGKEMYIIK G++ V+ DG
Sbjct: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578
Query: 508 TQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAK 567
L AGS FGEIS+L G GNRRTAN+ + G+++L L K L E + YPD++
Sbjct: 579 KVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSE 635
Query: 568 KVLEERGREILMKE 581
++L ++ R +L ++
Sbjct: 636 RILMKKARVLLKQK 649
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 294 bits (752), Expect = 2e-79
Identities = 149/441 (33%), Positives = 256/441 (58%), Gaps = 14/441 (3%)
Query: 140 YYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFI-RLRTGF 198
Y WLF + M +N L+ R F WL++DY+ D++Y D+ + + R F
Sbjct: 656 YVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQF 715
Query: 199 LEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFE 258
+ G ++ D K +R+NY+ + +FK+D+ S++P D +Y V ++ P +R R L + FE
Sbjct: 716 VRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYMAFFE 774
Query: 259 FFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYG 318
F R E+ + ++R+ Y+L +H N+C+YY S G G WVY +
Sbjct: 775 FNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGV------ 828
Query: 319 YLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNM 378
YI C Y++ TL TIG P P E +F + ++ GV F+ ++G + ++
Sbjct: 829 --GNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAA 886
Query: 379 NATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRA 438
A + +++ +D+ YM F K+ K ++ +V W++Y W ++ +DE E++ LP K+R
Sbjct: 887 TAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRL 946
Query: 439 EIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGK 498
++AI+V+ + + KV +F C+ ++ +++ +LR V+ P DY+C+KG+IG+EMYII+ G+
Sbjct: 947 DLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQ 1006
Query: 499 LAVV-ADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLM 557
+ V+ DG + L AGS FGEIS+L + G GNRRTAN+ + G+++LF L K DL
Sbjct: 1007 VQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDKKDLN 1063
Query: 558 EAVTEYPDAKKVLEERGREIL 578
E + YP+++K+L ++ R +L
Sbjct: 1064 EILVHYPESQKLLRKKARRML 1084
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 177 bits (450), Expect = 2e-44
Identities = 131/485 (27%), Positives = 232/485 (47%), Gaps = 47/485 (9%)
Query: 119 GEDKGTKKKFE------LFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYY 172
G K +K+ E +++ P D+ + W ++ + ++ N ++ F Q
Sbjct: 115 GSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTT-- 172
Query: 173 LVWLVLDYVSDVVYIADLFIRLRTGFLEQGL--LVKDTKKLRDNYIHTLQFKLDVASIIP 230
W++ + SD V++ DL + RTG + + ++ D K ++ NY+ + F +D S IP
Sbjct: 173 TPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSW-FVVDFISSIP 231
Query: 231 TDLIYFAVDIHSPE-----------VRFN------RLLHFARMFEFFDRTE-----TRTN 268
D I+ V+ VRF RLL +R+ + + E T
Sbjct: 232 VDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL 291
Query: 269 YPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPN-ITDPEYGYLAREYIYC 327
+ RI NL+ +L++ HW+ C+ + + F D WV N + + +G ++Y Y
Sbjct: 292 ASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWG---KQYSYA 348
Query: 328 LYWSTLTLTTIGE-TPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQ 386
L+ + + IG PV + + ++G +A VG+ ++I +++++R ++Q
Sbjct: 349 LFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQ 408
Query: 387 AKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHL 446
K V+ YM F K+ M K+ ++++ + K DE IL L LR EI
Sbjct: 409 EKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGK-IFDEENILNELNDPLREEIVNFNCR 467
Query: 447 STLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDG 506
+ + +F + + + ++ KLR +VF PGDYI R+G +GK+MY I+ G V+
Sbjct: 468 KLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS- 526
Query: 507 VTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDA 566
++ L+ GS FGEI +L KG RRTA++R+ Y L+ LS D+ E + EYP
Sbjct: 527 -SKEMKLTDGSYFGEICLLT-KG-----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMM 579
Query: 567 KKVLE 571
++ E
Sbjct: 580 RRAFE 584
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 171 bits (433), Expect = 2e-42
Identities = 125/473 (26%), Positives = 227/473 (47%), Gaps = 43/473 (9%)
Query: 126 KKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVV 185
K +++ P D+ + W + + ++ N ++ F + W+V + VSD
Sbjct: 248 KSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTPWIVFNVVSDTF 305
Query: 186 YIADLFIRLRTGFL--EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSP 243
++ DL + RTG + + ++ D ++++ Y+ + F +D S IP D I+ V+
Sbjct: 306 FLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRID 364
Query: 244 E-----------VRFN------RLLHFARMFEFFDRTE-----TRTNYPNIFRISNLVLY 281
VRF RLL +R+ + + E T + RI NL+
Sbjct: 365 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGM 424
Query: 282 ILVIIHWNACIYYAISKSIGFGVDTWV-YPNITDPEYGYLAREYIYCLYWSTLTLTTIGE 340
+L++ HW+ C+ + + F D WV N+ + +G ++Y Y L+ + + IG
Sbjct: 425 MLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWG---KQYSYALFKAMSHMLCIGY 481
Query: 341 -TPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFR 399
PV + + ++G +A +G+ ++I +++++R ++Q K V+ YM F
Sbjct: 482 GRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 541
Query: 400 KVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTL-KKVRIFHDC 458
K+ ++ ++++ + K DE IL L LR EI IN + L + +F +
Sbjct: 542 KLPPDTRQRIHDYYEHRYQGKM-FDEESILGELSEPLREEI-INFNCRKLVASMPLFANA 599
Query: 459 EAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSC 518
+ + ++ KLR +VF PGDYI R+G IGK+MY I+ G ++V+ + L+ GS
Sbjct: 600 DPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKETKLADGSY 657
Query: 519 FGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLE 571
FGEI +L RRTA++R+ Y L+ LS D+ E + EYP ++ E
Sbjct: 658 FGEICLLT------RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 704
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 167 bits (423), Expect = 3e-41
Identities = 124/467 (26%), Positives = 223/467 (47%), Gaps = 41/467 (8%)
Query: 131 FVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADL 190
+++ P D+ + W F + + ++ N ++ F + W+V + VSD ++ DL
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFLMDL 259
Query: 191 FIRLRTGFL--EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVD--IHSPE-- 244
+ RTG + + ++ D +K++ Y+ T F +D S IP D I+ V+ I S
Sbjct: 260 VLNFRTGIVIEDNTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYK 318
Query: 245 -------VRFN------RLLHFARMFEFFDRTE-----TRTNYPNIFRISNLVLYILVII 286
VRF RLL +R+ + + E T + RI NL+ +L++
Sbjct: 319 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 378
Query: 287 HWNACIYYAISKSIGFGVDTWVYPN-ITDPEYGYLAREYIYCLYWSTLTLTTIGE-TPPP 344
HW+ C+ + + F + WV N + + + L Y + L+ + + IG P
Sbjct: 379 HWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSEL---YSFALFKAMSHMLCIGYGRQAP 435
Query: 345 VKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKG 404
+ + ++G +A +G+ ++I +++++R ++Q K V+ YM F K+
Sbjct: 436 ESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPAD 495
Query: 405 MEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLV 464
K+ ++++ + K DE IL L LR EI + + +F + + +
Sbjct: 496 FRQKIHDYYEHRYQGKM-FDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVT 554
Query: 465 ELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISI 524
++ KL+ +VF PGDYI R+G IGK+MY I+ G ++V+ + LS GS FGEI +
Sbjct: 555 AMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEMKLSDGSYFGEICL 612
Query: 525 LNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLE 571
L RRTA++R+ Y L+ LS D+ E + EYP ++ E
Sbjct: 613 LT------RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 653
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 164 bits (415), Expect = 2e-40
Identities = 122/480 (25%), Positives = 228/480 (47%), Gaps = 43/480 (8%)
Query: 131 FVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADL 190
+++ P D+ + W ++ + ++ N +L F + W+V + +SD ++ DL
Sbjct: 84 WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSP--PWIVFNVLSDTFFLLDL 141
Query: 191 FIRLRTGFL-EQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPE---- 244
+ RTG + E+G ++ + +R Y+ T F +D+ S IP D I+ V++
Sbjct: 142 VLNFRTGIVVEEGAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEV 200
Query: 245 ---------VRFN------RLLHFARMFEFFDRTE-----TRTNYPNIFRISNLVLYILV 284
VRF RLL +R+ + + E T + RI NL+ +L+
Sbjct: 201 YKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLL 260
Query: 285 IIHWNACIYYAISKSIGFGVDTWVYPN-ITDPEYGYLAREYIYCLYWSTLTLTTIGE-TP 342
+ HW+ C+ + + F D WV N + + +G R+Y + L+ + + IG
Sbjct: 261 LCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWG---RQYSHALFKAMSHMLCIGYGQQ 317
Query: 343 PPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVS 402
PV + + ++G +A +G+ ++I +++++R ++Q K V+ YM F K+
Sbjct: 318 APVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP 377
Query: 403 KGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGL 462
++ ++++ + K DE IL L LR EI + + +F +
Sbjct: 378 ADTRQRIHEYYEHRYQGKM-FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSF 436
Query: 463 LVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEI 522
+ ++ KLR +VF PGD + R+G +G++MY I+ G L+V+A + L+ GS FGEI
Sbjct: 437 VTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEI 494
Query: 523 SILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEG 582
+L RRTA++R+ Y L+ LS D + E+P ++ E + L++ G
Sbjct: 495 CLLT------RGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIG 548
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 154 bits (388), Expect = 3e-37
Identities = 112/409 (27%), Positives = 199/409 (48%), Gaps = 31/409 (7%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D+++I D+ I RT ++ Q +V D K+ +Y F +D+ + IP DL+
Sbjct: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 511
Query: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNA 290
F ++ RLL R+ DR + Y + + ++ L I HW A
Sbjct: 512 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRY---SEYGAAVLMLLMCIFAL-IAHWLA 567
Query: 291 CIYYAISK--------SIGF----GVDTWVYPNITDPEYGYLARE-YIYCLYWSTLTLTT 337
CI+YAI IG+ G N +D G ++ Y+ LY++ +LT+
Sbjct: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627
Query: 338 IG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYM 396
+G P + E +F I LIG L++A+I GNV ++I + + A + ++ VK ++
Sbjct: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687
Query: 397 QFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFH 456
+F ++ + ++ +F + WT +D +LK P L+A+I ++++ + L+ + F
Sbjct: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747
Query: 457 DCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAG 516
G L L +K + PGD + GD+ +Y + G + ++ DD V A+L
Sbjct: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805
Query: 517 SCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565
FGE+ L K K A++R+L Y DL + ++DL+E + YP+
Sbjct: 806 DIFGEMVHLYAKPGK----SNADVRALTYCDLHKIQREDLLEVLDMYPE 850
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 152 bits (384), Expect = 1e-36
Identities = 145/583 (24%), Positives = 256/583 (43%), Gaps = 87/583 (14%)
Query: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194
+YC W +VI + Y ++ F Q + WLVLD V DV+++ D+ +
Sbjct: 209 HYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNF 266
Query: 195 RTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253
T F+ G ++ D K +R NY+ T F +D+ S +P D+I ++ L
Sbjct: 267 HTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKV 325
Query: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILV---IIHWNACIYYAISK-------SIGFG 303
R+ R + ++ + + LVL + V + HW ACI+Y+I +
Sbjct: 326 VRLLRL-GRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQ 384
Query: 304 VDTWVYP---NITDPEYGYLARE------------YIYCLYWSTLTLTTIG-ETPPPVKD 347
+D+W+Y +I P Y Y Y+ LY++ +LTTIG P D
Sbjct: 385 IDSWLYQLALSIGTP-YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443
Query: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407
E +F + ++G L++ATI GNV ++ M A + ++ V+ +++ +V KG+
Sbjct: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503
Query: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467
+V+ + W+ K +D ++L P +RA+I ++++ + F G L L
Sbjct: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563
Query: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527
++ + +PGD I G+ + + G L V+ DD V A+L G FG+I
Sbjct: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIF---W 618
Query: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD---------------AKKVLEE 572
K + + + AN+R+L Y DL + ++ L++ + Y K+++
Sbjct: 619 KETTLAH-ACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFR 677
Query: 573 RGREILM--KEGLLDENEVATSMEVD-----------VQEKL-------GQLETNMETLY 612
+ ++ +E L +NEV S+ VD Q++L G E N +
Sbjct: 678 KISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVE 737
Query: 613 TRFGRLLAEYTGAQQKLKQRITVLET---------KMKQNNED 646
+R + A TG +IT ++T +KQNN D
Sbjct: 738 SRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRD 780
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 150 bits (380), Expect = 3e-36
Identities = 117/456 (25%), Positives = 209/456 (45%), Gaps = 42/456 (9%)
Query: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194
+YC W ++I + Y L+ F Q + WLV+D + DV+++ D+ +
Sbjct: 212 HYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNF 269
Query: 195 RTGFL-EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253
T F+ G ++ D K +R NY+ T F +D+ S +P D+I ++ L
Sbjct: 270 HTTFVGPAGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEGISSLFSSLKV 328
Query: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILVI---IHWNACIYYAISKSIGFGVDT---- 306
R+ R + ++ + + LVL + V HW ACI+Y+I F DT
Sbjct: 329 VRLLRL-GRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR 387
Query: 307 ---WVYPNITDPEYGYLARE---------------YIYCLYWSTLTLTTIG-ETPPPVKD 347
W+Y D Y YI LY++ +LT++G P D
Sbjct: 388 NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTD 447
Query: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407
E +F + +IG L++ATI GNV ++ M A + +++V+ +++ +V KG+
Sbjct: 448 IEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSE 507
Query: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467
+V+ + W+ + +D ++L+ P +RA+I ++++ K+ F G L L
Sbjct: 508 RVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA 567
Query: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527
++ + +PGD I G+ + + G L V+ DD V A+L G FG++
Sbjct: 568 MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVF---W 622
Query: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY 563
K + + + AN+R+L Y DL + +D L + + Y
Sbjct: 623 KEATLA-QSCANVRALTYCDLHVIKRDALQKVLEFY 657
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 150 bits (379), Expect = 4e-36
Identities = 119/456 (26%), Positives = 212/456 (46%), Gaps = 43/456 (9%)
Query: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194
+YC W +VI + Y ++ F Q + WLVLD V DV+++ D+ +
Sbjct: 151 HYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNF 208
Query: 195 RTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253
T F+ G ++ D K +R NY+ T F +D+ S +P D+I ++ L
Sbjct: 209 HTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKV 267
Query: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILV---IIHWNACIYYAISK-------SIGFG 303
R+ R + ++ + + LVL + V + HW ACI+Y+I +
Sbjct: 268 VRLLRL-GRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQ 326
Query: 304 VDTWVYP---NITDPEYGYLARE------------YIYCLYWSTLTLTTIG-ETPPPVKD 347
+D+W+Y +I P Y Y Y+ LY++ +LTTIG P D
Sbjct: 327 IDSWLYQLALSIGTP-YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 385
Query: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407
E +F + ++G L++ATI GNV ++ M A + ++ V+ +++ +V KG+
Sbjct: 386 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 445
Query: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467
+V+ + W+ K +D ++L P +RA+I ++++ + F G L L
Sbjct: 446 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 505
Query: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527
++ + +PGD I G+ + + G L V+ DD V A+L G FG+I
Sbjct: 506 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIF---W 560
Query: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY 563
K + + + AN+R+L Y DL + ++ L++ + Y
Sbjct: 561 KETTLAH-ACANVRALTYCDLHIIKREALLKVLDFY 595
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 149 bits (377), Expect = 6e-36
Identities = 111/413 (26%), Positives = 197/413 (47%), Gaps = 41/413 (9%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D++++ D+ I RT ++ +V +++ +Y F +D+ + IP DL+
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
Query: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----I 285
F ++ RLL R+ DR VL++L+ I
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALI 411
Query: 286 IHWNACIYYAISK--------SIGF----GVDTWVYPNITDPEYGYLARE-YIYCLYWST 332
HW ACI+YAI IG+ GV N +DP G ++ Y+ LY++
Sbjct: 412 AHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTF 471
Query: 333 LTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDA 391
+LT++G P + E +F I LIG L++A+I GNV ++I + + A + ++
Sbjct: 472 SSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLR 531
Query: 392 VKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKK 451
VK +++F ++ + ++ +F + W+ +D +LK P L+A+I +++H + L+
Sbjct: 532 VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQH 591
Query: 452 VRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYA 511
F G L L +K + PGD + GD+ +Y I G + ++ DD V A
Sbjct: 592 CPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--A 649
Query: 512 LLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYP 564
+L FGE L+ + K +A++R+L Y DL + + DL+E + YP
Sbjct: 650 ILGKNDIFGEPVSLHAQPGK----SSADVRALTYCDLHKIQRADLLEVLDMYP 698
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 143 bits (361), Expect = 4e-34
Identities = 123/491 (25%), Positives = 212/491 (43%), Gaps = 85/491 (17%)
Query: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194
+YC W ++I + Y L+ F Q + WLV+D + DV+++ D+ +
Sbjct: 212 HYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNF 269
Query: 195 RTGFL-EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY------------------ 235
T F+ G ++ D K +R NY+ T F +D+ S +P D+I
Sbjct: 270 HTTFVGPAGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEVSAFMGDPGKI 328
Query: 236 -FAVDIHSP--------------EVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVL 280
FA I P ++ RLL R+ D + VL
Sbjct: 329 GFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVL 379
Query: 281 YILVII-----HWNACIYYAISKSIGFGVDT-------WVYPNITDPEYGYLARE----- 323
+LV + HW ACI+Y+I F DT W+Y D Y
Sbjct: 380 VLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGK 439
Query: 324 ----------YIYCLYWSTLTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVG 372
YI LY++ +LT++G P D E +F + +IG L++ATI GNV
Sbjct: 440 WEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVT 499
Query: 373 SMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNL 432
++ M A + +++V+ +++ +V KG+ +V+ + W+ + +D ++L+
Sbjct: 500 TIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQIC 559
Query: 433 PAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMY 492
P +RA+I ++++ K+ F G L L ++ + +PGD I G+ +
Sbjct: 560 PKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLC 619
Query: 493 IIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLS 552
+ G L V+ DD V A+L G FG++ K + + + AN+R+L Y DL +
Sbjct: 620 FVVSGSLEVIQDDEVV--AILGKGDVFGDVF---WKEATLA-QSCANVRALTYCDLHVIK 673
Query: 553 KDDLMEAVTEY 563
+D L + + Y
Sbjct: 674 RDALQKVLEFY 684
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 140 bits (354), Expect = 3e-33
Identities = 115/450 (25%), Positives = 221/450 (49%), Gaps = 40/450 (8%)
Query: 145 FVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQ-GL 203
F +A+ V YN C + DL V D ++++I D+ + RT ++ + G
Sbjct: 233 FYVAVTVPYNVCFIGN----DDLSTTRSTT--VSDIAVEILFIIDIILNFRTTYVSKSGQ 286
Query: 204 LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY-FAVDIHSPE--VRFNRLLHFARMFEFF 260
++ + + + +Y+ T F +D+ + +P DL+Y F V + S ++ RLL R+ +
Sbjct: 287 VIFEARSICIHYV-TTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKL 345
Query: 261 DRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISK------SIGFGVDTWVYP---N 311
DR + ++ L+ ++ HW ACI+Y I K S+ W++
Sbjct: 346 DRYSQHSTIV----LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKR 401
Query: 312 ITDPEYGY-------LAREYIYCLYWSTLTLTTIGETPPPVK-DEEYLFVIFDFLIGVLI 363
+ P YG + YI LY++ +LT++G D E +F I LIG L+
Sbjct: 402 LESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALM 461
Query: 364 FATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTV 423
A + GNV ++I M + + + + +K +++ + + ++ +++ +F W+ +
Sbjct: 462 HALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGI 521
Query: 424 DEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICR 483
D E+LK+ P +LR++I ++++ L ++ +F G L L L ++ +PG+Y+ R
Sbjct: 522 DSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLR 580
Query: 484 KGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSL 543
+GD + +Y + G + V+ D V A+L G G + L+IK + + A++++L
Sbjct: 581 QGDALQAIYFVCSGSMEVLKDSMV--LAILGKGDLIG--ANLSIKDQVI--KTNADVKAL 634
Query: 544 GYSDLFCLSKDDLMEAVTEYPD-AKKVLEE 572
Y DL C+ L E + YP+ A K +E+
Sbjct: 635 TYCDLQCIILKGLFEVLDLYPEYAHKFVED 664
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 140 bits (352), Expect = 5e-33
Identities = 107/411 (26%), Positives = 195/411 (47%), Gaps = 39/411 (9%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D+++I D+ I RT ++ +V ++ +Y F +D+ + IP DL+
Sbjct: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 172
Query: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288
F ++ RLL R+ DR VL++L+ I HW
Sbjct: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223
Query: 289 NACIYYAISKSIGFGVDT---WVYPNITDP---EYGY-------LAREYIYCLYWSTLTL 335
ACI+YAI +D+ W++ N+ D Y + +Y+ LY++ +L
Sbjct: 224 LACIWYAIGNMEQPHMDSRIGWLH-NLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSL 282
Query: 336 TTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKH 394
T++G P + E +F I LIG L++A+I GNV ++I + + A + ++ V+
Sbjct: 283 TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVRE 342
Query: 395 YMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRI 454
+++F ++ + ++ +F + W+ +D +LK P L+A+I ++++ S L+ +
Sbjct: 343 FIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKP 402
Query: 455 FHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLS 514
F G L L +K + PGD + GD+ +Y I G + ++ D V A+L
Sbjct: 403 FRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILG 460
Query: 515 AGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565
FGE L + K ++R+L Y DL + +DDL+E + YP+
Sbjct: 461 KNDIFGEPLNLYARPGK----SNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 140 bits (352), Expect = 5e-33
Identities = 107/411 (26%), Positives = 195/411 (47%), Gaps = 39/411 (9%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D+++I D+ I RT ++ +V ++ +Y F +D+ + IP DL+
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 512
Query: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288
F ++ RLL R+ DR VL++L+ I HW
Sbjct: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
Query: 289 NACIYYAISKSIGFGVDT---WVYPNITDP---EYGY-------LAREYIYCLYWSTLTL 335
ACI+YAI +D+ W++ N+ D Y + +Y+ LY++ +L
Sbjct: 564 LACIWYAIGNMEQPHMDSRIGWLH-NLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSL 622
Query: 336 TTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKH 394
T++G P + E +F I LIG L++A+I GNV ++I + + A + ++ V+
Sbjct: 623 TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVRE 682
Query: 395 YMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRI 454
+++F ++ + ++ +F + W+ +D +LK P L+A+I ++++ S L+ +
Sbjct: 683 FIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKP 742
Query: 455 FHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLS 514
F G L L +K + PGD + GD+ +Y I G + ++ D V A+L
Sbjct: 743 FRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILG 800
Query: 515 AGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565
FGE L + K ++R+L Y DL + +DDL+E + YP+
Sbjct: 801 KNDIFGEPLNLYARPGK----SNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 134 bits (337), Expect = 3e-31
Identities = 103/400 (25%), Positives = 183/400 (45%), Gaps = 37/400 (9%)
Query: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194
+YC W +VI + Y ++ F Q + WLVLD V DV+++ D+ +
Sbjct: 209 HYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNF 266
Query: 195 RTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253
T F+ G ++ D K +R NY+ T F +D+ S +P D+I ++ L
Sbjct: 267 HTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKV 325
Query: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILV---IIHWNACIYYAISK-------SIGFG 303
R+ R + ++ + + LVL + V + HW ACI+Y+I +
Sbjct: 326 VRLLRL-GRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQ 384
Query: 304 VDTWVYP---NITDPEYGYLARE------------YIYCLYWSTLTLTTIG-ETPPPVKD 347
+D+W+Y +I P Y Y Y+ LY++ +LTTIG P D
Sbjct: 385 IDSWLYQLALSIGTP-YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443
Query: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407
E +F + ++G L++ATI GNV ++ M A + ++ V+ +++ +V KG+
Sbjct: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503
Query: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467
+V+ + W+ K +D ++L P +RA+I ++++ + F G L L
Sbjct: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563
Query: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGV 507
++ + +PGD I G+ + + G L V+ DD V
Sbjct: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEV 603
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 131 bits (329), Expect = 2e-30
Identities = 108/435 (24%), Positives = 201/435 (46%), Gaps = 56/435 (12%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQ-GLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V D +V++I D+ + RT F+ + G +V K + +Y+ T F LDV + +P DL++
Sbjct: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLH 321
Query: 236 -FAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYY 294
F V+++ + + R+ R + + Y + ++ L+ ++ HW AC+++
Sbjct: 322 AFKVNVYFG-AHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWF 379
Query: 295 AISK-----------SIGF------GVDTWVYPNITDPEYGY------------------ 319
I + IG+ ++T Y P G
Sbjct: 380 YIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTG 439
Query: 320 --------LAREYIYCLYWSTLTLTTIGETPPPVK-DEEYLFVIFDFLIGVLIFATIVGN 370
L YI LY++ +LT++G D E +F I LIG L+ A + GN
Sbjct: 440 LELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGN 499
Query: 371 VGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILK 430
V ++I M A R + ++ ++ Y++ ++ K ++ +++ +F W +D E+L+
Sbjct: 500 VTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQ 559
Query: 431 NLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKE 490
+LP +LRA+IA+++H L ++ +F G L L L LRP +PG+Y+ +GD +
Sbjct: 560 SLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQA 618
Query: 491 MYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFC 550
+Y + G + V+ G T A+L G G + + + A+++ L Y L C
Sbjct: 619 LYFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQC 672
Query: 551 LSKDDLMEAVTEYPD 565
L L +++ YP+
Sbjct: 673 LQLAGLHDSLALYPE 687
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 130 bits (326), Expect = 5e-30
Identities = 102/415 (24%), Positives = 202/415 (48%), Gaps = 32/415 (7%)
Query: 176 LVLDYVSDVVYIADLFIRLRTGFLEQ-GLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLI 234
LV D ++++I D+ + RT ++ Q G ++ + + +Y+ T F +D+ + +P DL+
Sbjct: 264 LVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFF-IDLIAALPFDLL 322
Query: 235 YFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYY 294
Y + V + + R+ + E R + + ++ L+ ++ HW ACI+Y
Sbjct: 323 YIFNITVTSLVHLLKTVRLLRLLRLLQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWY 381
Query: 295 AISKSIGFGVDT------WVY--------PNITDPEYGYLARE-YIYCLYWSTLTLTTIG 339
I + D W++ P + G R YI LY++ +LT++G
Sbjct: 382 VIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVG 441
Query: 340 ETPPPVK-DEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQF 398
D E +F I LIG L+ A + GNV ++I M + R+ + +++ +K +++
Sbjct: 442 FGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRV 501
Query: 399 RKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDC 458
++ + ++ +++ +F W +D E+L++ P +LRA+IA++++ L ++ +F
Sbjct: 502 HRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAA 560
Query: 459 EAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSC 518
G L L L ++ +PG+Y+ R+GD + Y + G L V+ D+ V A+L G
Sbjct: 561 SRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDL 618
Query: 519 FGEISILNIKGSKMG--------NRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565
G + + G + G + +A++++L Y L LS L E + YP+
Sbjct: 619 IG--ADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 126 bits (316), Expect = 7e-29
Identities = 99/399 (24%), Positives = 177/399 (44%), Gaps = 66/399 (16%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D++++ D+ I RT ++ +V +++ +Y F +D+ + IP DL+
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
Query: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----I 285
F ++ RLL R+ DR VL++L+ I
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALI 411
Query: 286 IHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPV 345
HW ACI S+GFG N++ P
Sbjct: 412 AHWLACI--CSLTSVGFG-------NVS------------------------------PN 432
Query: 346 KDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGM 405
+ E +F I LIG L++A+I GNV ++I + + A + ++ VK +++F ++ +
Sbjct: 433 TNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPL 492
Query: 406 EAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVE 465
++ +F + W+ +D +LK P L+A+I +++H + L+ F G L
Sbjct: 493 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRA 552
Query: 466 LVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISIL 525
L +K + PGD + GD+ +Y I G + ++ DD V A+L FGE L
Sbjct: 553 LAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSL 610
Query: 526 NIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYP 564
+ + K +A++R+L Y DL + + DL+E + YP
Sbjct: 611 HAQPGK----SSADVRALTYCDLHKIQRADLLEVLDMYP 645
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 121 bits (304), Expect = 2e-27
Identities = 100/397 (25%), Positives = 185/397 (46%), Gaps = 37/397 (9%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D+++I D+ I RT ++ +V ++ +Y F +D+ + IP DL+
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 512
Query: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288
F ++ RLL R+ DR VL++L+ I HW
Sbjct: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
Query: 289 NACIYYAISKSIGFGVDT---WVYPNITDP---EYGY-------LAREYIYCLYWSTLTL 335
ACI+YAI +D+ W++ N+ D Y + +Y+ LY++ +L
Sbjct: 564 LACIWYAIGNMEQPHMDSRIGWLH-NLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSL 622
Query: 336 TTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKH 394
T++G P + E +F I LIG L++A+I GNV ++I + + A + ++ V+
Sbjct: 623 TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVRE 682
Query: 395 YMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRI 454
+++F ++ + ++ +F + W+ +D +LK P L+A+I ++++ S L+ +
Sbjct: 683 FIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKP 742
Query: 455 FHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLS 514
F G L L +K + PGD + GD+ +Y I G + ++ D V A+L
Sbjct: 743 FRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILG 800
Query: 515 AGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCL 551
G +G + L + + N++SLG CL
Sbjct: 801 MG--WGAGTGLEMPSAASRGASLLNMQSLGLWTWDCL 835
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 88.2 bits (217), Expect = 2e-17
Identities = 71/268 (26%), Positives = 128/268 (47%), Gaps = 25/268 (9%)
Query: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
V+D + D+++I D+ I RT ++ Q +V D K+ +Y F +D+ + IP DL+
Sbjct: 446 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 504
Query: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNA 290
F ++ RLL R+ DR + Y + + ++ L I HW A
Sbjct: 505 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRY---SEYGAAVLMLLMCIFAL-IAHWLA 560
Query: 291 CIYYAISK--------SIGF----GVDTWVYPNITDPEYGYLARE-YIYCLYWSTLTLTT 337
CI+YAI IG+ G N +D G ++ Y+ LY++ +LT+
Sbjct: 561 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 620
Query: 338 IG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYM 396
+G P + E +F I LIG L++A+I GNV ++I + + A + ++ VK ++
Sbjct: 621 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 680
Query: 397 QFRKVSKGMEAKVIRWFDYLWTNKKTVD 424
+F ++ + ++ +F + WT +D
Sbjct: 681 RFHQIPNPLRQRLEEYFQHAWTYTNGID 708
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/161 (26%), Positives = 81/161 (50%), Gaps = 15/161 (9%)
Query: 418 TNKKT-VDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFS 476
TN KT +RE+ +N+ + A+ + + L+ V + + L +++ L + +
Sbjct: 250 TNVKTWALDREVFQNIMRRT-AQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYD 308
Query: 477 PGDYICRKGDIGKEMYIIKEGKLAVV-ADDGVTQYAL---LSAGSCFGEISILNIKGSKM 532
GDYI R+G+ G +I+ +GK+ V + +G Q L L G FGE ++++
Sbjct: 309 KGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALIS------ 362
Query: 533 GNRRTANIRSLGYSDLFCL--SKDDLMEAVTEYPDAKKVLE 571
+ R+ANI + +D+ CL ++ + V + + +K LE
Sbjct: 363 DDVRSANIIA-EENDVACLVIDRETFNQTVGTFEELQKYLE 402
Score = 34.7 bits (78), Expect = 0.29
Identities = 28/132 (21%), Positives = 59/132 (44%), Gaps = 17/132 (12%)
Query: 475 FSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGN 534
+ G YI ++G+ G ++++ EG+L V G + + + FGE++IL
Sbjct: 189 YQQGSYIIKQGEPGNHIFVLAEGRLEVF--QGEKLLSSIPMWTTFGELAIL------YNC 240
Query: 535 RRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDE------NE 588
RTA+++++ + L ++ + A+ +E+ R L LL +
Sbjct: 241 TRTASVKAITNVKTWALDREVFQNIMRRTAQAR---DEQYRNFLRSVSLLKNLPEDKLTK 297
Query: 589 VATSMEVDVQEK 600
+ +EV+ +K
Sbjct: 298 IIDCLEVEYYDK 309
>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
sapiens]
Length = 1327
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/147 (25%), Positives = 65/147 (44%), Gaps = 13/147 (8%)
Query: 433 PAKLRAEIA----INVHLST-----LKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICR 483
PA L A++ N HL + LK VR+ E L +EL + Q GDY+ R
Sbjct: 117 PAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFR 176
Query: 484 KGDIGKEMYIIKEG--KLAVVADDG--VTQYALLSAGSCFGEISILNIKGSKMGNRRTAN 539
G +Y++++G +L + DG ++ S +SIL++ +RT +
Sbjct: 177 PGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVS 236
Query: 540 IRSLGYSDLFCLSKDDLMEAVTEYPDA 566
R+ S + L + T+YP++
Sbjct: 237 ARAARDSTVLRLPVEAFSAVFTKYPES 263
>gi|18201890 hypothetical protein LOC140894 [Homo sapiens]
Length = 572
Score = 39.3 bits (90), Expect = 0.012
Identities = 48/204 (23%), Positives = 88/204 (43%), Gaps = 24/204 (11%)
Query: 427 EILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGD 486
+I++ P+ R E I + L+ + + + L + L +R + F I +KG
Sbjct: 90 QIMQKKPS-WRTEDEIQAVCNILQVLDSYRNYAEPLQLLLAKVMRFERFGRRRVIIKKGQ 148
Query: 487 IGKEMYIIKEGKLAVVAD-DGVTQYA-----LLSAGSCFGEISILNIKGSKMGNRRTANI 540
G Y I G +A+ D DG + + LL GSCFGE+ +L+ A++
Sbjct: 149 KGNSFYFIYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLH-----------ASV 197
Query: 541 RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK 600
R S + C+ + + + E A K+ +E ++ + + E+ S EK
Sbjct: 198 RR---STIVCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFASWS---DEK 251
Query: 601 LGQLETNMETLYTRFGRLLAEYTG 624
L QL + +G+L+++ G
Sbjct: 252 LWQLVAMAKIERFSYGQLISKDFG 275
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,228,773
Number of Sequences: 37866
Number of extensions: 1059803
Number of successful extensions: 3210
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3070
Number of HSP's gapped (non-prelim): 107
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.