Search of human proteins with 42716287

Search of human proteins with 42716287

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42716287 WD repeat domain 41 [Homo sapiens]
         (459 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42716287 WD repeat domain 41 [Homo sapiens]                        930   0.0  
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    61   2e-09
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    61   2e-09
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    61   2e-09
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    57   5e-08
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    53   5e-07
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    53   5e-07
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    52   1e-06
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    52   1e-06
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    52   1e-06
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    49   7e-06
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s...    49   1e-05
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]               47   4e-05
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]               47   4e-05
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    47   4e-05
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    47   4e-05
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    46   6e-05
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    46   6e-05
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    46   6e-05
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    46   6e-05
gi|32189425 WD repeat domain 69 [Homo sapiens]                         46   6e-05
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    45   2e-04
gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]         45   2e-04
gi|18874090 WD repeat domain 48 [Homo sapiens]                         44   2e-04
gi|23199987 WD repeat domain 5B [Homo sapiens]                         44   2e-04
gi|16554629 WD repeat domain 5 [Homo sapiens]                          44   4e-04
gi|16554627 WD repeat domain 5 [Homo sapiens]                          44   4e-04
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     43   5e-04
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    43   5e-04
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     43   7e-04

>gi|42716287 WD repeat domain 41 [Homo sapiens]
          Length = 459

 Score =  930 bits (2403), Expect = 0.0
 Identities = 459/459 (100%), Positives = 459/459 (100%)

Query: 1   MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASA 60
           MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASA
Sbjct: 1   MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASA 60

Query: 61  GDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDG 120
           GDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDG
Sbjct: 61  GDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDG 120

Query: 121 DTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSDTGISALV 180
           DTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSDTGISALV
Sbjct: 121 DTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSDTGISALV 180

Query: 181 EIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFVTGS 240
           EIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFVTGS
Sbjct: 181 EIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFVTGS 240

Query: 241 HVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAV 300
           HVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAV
Sbjct: 241 HVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAV 300

Query: 301 GRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAE 360
           GRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAE
Sbjct: 301 GRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAE 360

Query: 361 PVPTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLV 420
           PVPTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLV
Sbjct: 361 PVPTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLV 420

Query: 421 TCSADHLIILWKNGERESGLRSLRLFQKLEENGDLYLAV 459
           TCSADHLIILWKNGERESGLRSLRLFQKLEENGDLYLAV
Sbjct: 421 TCSADHLIILWKNGERESGLRSLRLFQKLEENGDLYLAV 459


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 9/122 (7%)

Query: 38  VLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLE 97
           VLK H D V   +Q    R  S  DD  + VW+A TG+ L  L GHT  +          
Sbjct: 257 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--------- 307

Query: 98  SCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCV 157
           S + ++ +I++ S DRT+ VW+ +T   +  +    STV+C+ + ++  V  S    L V
Sbjct: 308 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRV 367

Query: 158 WN 159
           W+
Sbjct: 368 WD 369



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 39/157 (24%), Positives = 71/157 (45%), Gaps = 12/157 (7%)

Query: 36  LLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           L VL  H   VR  VQ D  R  S   D +V VW+ +T   L  L GHT ++ + + F  
Sbjct: 376 LHVLMGHVAAVR-CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQFDG 433

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDL 155
           +         +++ S D ++ VWD +T   +  ++  QS    + +   + V  +  + +
Sbjct: 434 IH--------VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTV 485

Query: 156 CVWNRKLDLLCKTSHLSDTGISAL--VEIPKNCVVAA 190
            +W+ K     +T    +   SA+  ++  KN V+ +
Sbjct: 486 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS 522



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 47/225 (20%), Positives = 83/225 (36%), Gaps = 45/225 (20%)

Query: 39  LKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLES 98
           L  H   VR +  L + R  S   D  + VW+ +TG+ L  L GH   +  +        
Sbjct: 339 LYGHTSTVRCM-HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV-------- 389

Query: 99  CEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVW 158
            +   + +++ + D  V VWD +T               CL  LQ        G+   V+
Sbjct: 390 -QYDGRRVVSGAYDFMVKVWDPETE-------------TCLHTLQ--------GHTNRVY 427

Query: 159 NRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAP----TEGSLE----- 209
           + + D +   S   DT I        NC+    G + +   +         G+ +     
Sbjct: 428 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKI 487

Query: 210 WDI-----LEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWD 249
           WDI     L+  +  +   + ++ +  N    +T S  G + +WD
Sbjct: 488 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 532


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 9/122 (7%)

Query: 38  VLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLE 97
           VLK H D V   +Q    R  S  DD  + VW+A TG+ L  L GHT  +          
Sbjct: 375 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--------- 425

Query: 98  SCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCV 157
           S + ++ +I++ S DRT+ VW+ +T   +  +    STV+C+ + ++  V  S    L V
Sbjct: 426 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRV 485

Query: 158 WN 159
           W+
Sbjct: 486 WD 487



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 39/157 (24%), Positives = 71/157 (45%), Gaps = 12/157 (7%)

Query: 36  LLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           L VL  H   VR  VQ D  R  S   D +V VW+ +T   L  L GHT ++ + + F  
Sbjct: 494 LHVLMGHVAAVR-CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQFDG 551

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDL 155
           +         +++ S D ++ VWD +T   +  ++  QS    + +   + V  +  + +
Sbjct: 552 IH--------VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTV 603

Query: 156 CVWNRKLDLLCKTSHLSDTGISAL--VEIPKNCVVAA 190
            +W+ K     +T    +   SA+  ++  KN V+ +
Sbjct: 604 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS 640



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 47/225 (20%), Positives = 83/225 (36%), Gaps = 45/225 (20%)

Query: 39  LKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLES 98
           L  H   VR +  L + R  S   D  + VW+ +TG+ L  L GH   +  +        
Sbjct: 457 LYGHTSTVRCM-HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV-------- 507

Query: 99  CEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVW 158
            +   + +++ + D  V VWD +T               CL  LQ        G+   V+
Sbjct: 508 -QYDGRRVVSGAYDFMVKVWDPETE-------------TCLHTLQ--------GHTNRVY 545

Query: 159 NRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAP----TEGSLE----- 209
           + + D +   S   DT I        NC+    G + +   +         G+ +     
Sbjct: 546 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKI 605

Query: 210 WDI-----LEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWD 249
           WDI     L+  +  +   + ++ +  N    +T S  G + +WD
Sbjct: 606 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 650


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 9/122 (7%)

Query: 38  VLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLE 97
           VLK H D V   +Q    R  S  DD  + VW+A TG+ L  L GHT  +          
Sbjct: 295 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--------- 345

Query: 98  SCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCV 157
           S + ++ +I++ S DRT+ VW+ +T   +  +    STV+C+ + ++  V  S    L V
Sbjct: 346 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRV 405

Query: 158 WN 159
           W+
Sbjct: 406 WD 407



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 39/157 (24%), Positives = 71/157 (45%), Gaps = 12/157 (7%)

Query: 36  LLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           L VL  H   VR  VQ D  R  S   D +V VW+ +T   L  L GHT ++ + + F  
Sbjct: 414 LHVLMGHVAAVR-CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQFDG 471

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDL 155
           +         +++ S D ++ VWD +T   +  ++  QS    + +   + V  +  + +
Sbjct: 472 IH--------VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTV 523

Query: 156 CVWNRKLDLLCKTSHLSDTGISAL--VEIPKNCVVAA 190
            +W+ K     +T    +   SA+  ++  KN V+ +
Sbjct: 524 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS 560



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 47/225 (20%), Positives = 83/225 (36%), Gaps = 45/225 (20%)

Query: 39  LKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLES 98
           L  H   VR +  L + R  S   D  + VW+ +TG+ L  L GH   +  +        
Sbjct: 377 LYGHTSTVRCM-HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV-------- 427

Query: 99  CEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVW 158
            +   + +++ + D  V VWD +T               CL  LQ        G+   V+
Sbjct: 428 -QYDGRRVVSGAYDFMVKVWDPETE-------------TCLHTLQ--------GHTNRVY 465

Query: 159 NRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAP----TEGSLE----- 209
           + + D +   S   DT I        NC+    G + +   +         G+ +     
Sbjct: 466 SLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKI 525

Query: 210 WDI-----LEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWD 249
           WDI     L+  +  +   + ++ +  N    +T S  G + +WD
Sbjct: 526 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWD 570


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 46/135 (34%), Positives = 62/135 (45%), Gaps = 14/135 (10%)

Query: 39  LKAHHDIVRFL-VQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLE 97
           LK H   V  L    D     SA  D  V VW+++TGE++  L GHT  +       S  
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN------SCY 158

Query: 98  SCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVL--QRLDVWLSGG--N 153
                 QL+ T S D TV +WD    R+   I  FQ+T + L V      D  +SGG  N
Sbjct: 159 PARRGPQLVCTGSDDGTVKLWD---IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDN 215

Query: 154 DLCVWNRKLDLLCKT 168
           D+ VW+ + + L  T
Sbjct: 216 DIKVWDLRQNKLTYT 230



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 83/379 (21%), Positives = 151/379 (39%), Gaps = 77/379 (20%)

Query: 5   LIGGGREP---QGLAEKSPLQTIGEEQTQNPYTELLVLKAHH-DIVRFLVQLDDYRFASA 60
           L+G G  P   Q  A    L   G  +  +    +++L  H  ++       +    ASA
Sbjct: 25  LLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASA 84

Query: 61  GDDGIVVVWNAQTG-EKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWD 119
           G D ++++WN     +    L GH+  +  +              ++ +AS D+TV VWD
Sbjct: 85  GFDRLILLWNVYGDCDNYATLKGHSGAVMEL-------HYNTDGSMLFSASTDKTVAVWD 137

Query: 120 GDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSDTGISAL 179
            +T  +V+R+    S V                N      R   L+C     SD G   L
Sbjct: 138 SETGERVKRLKGHTSFV----------------NSCYPARRGPQLVCTG---SDDGTVKL 178

Query: 180 VEIPKNCVVAAVGKELIIFRLVAPT---------EGSLEWDILEVKRLLDHQDNILSLIN 230
            +I K    AA+      ++++A T          G ++ DI    ++ D + N L+   
Sbjct: 179 WDIRKK---AAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDI----KVWDLRQNKLTYTM 231

Query: 231 VNDLSFVTG---SHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIH 287
                 VTG   S  G  ++ +A+D T++      WD  P    ++ +K+ Q     ++H
Sbjct: 232 RGHADSVTGLSLSSEGSYLLSNAMDNTVRV-----WDVRPFAPKERCVKIFQG----NVH 282

Query: 288 HFTCDEENVF-------------AAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPN 334
           +F   E+N+               +  R +YV+    +R++  +   H  ++  VA  P+
Sbjct: 283 NF---EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL-YKLPGHAGSINEVAFHPD 338

Query: 335 RQ-LISCSEDGSVRIWELR 352
              +IS S D  + + E++
Sbjct: 339 EPIIISASSDKRLYMGEIQ 357


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 45/221 (20%), Positives = 93/221 (42%), Gaps = 13/221 (5%)

Query: 35  ELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLL---ELNGHTQKITAII 91
           E+L    HH      ++ ++    +   D  + VW+  +   +     L GH   +  + 
Sbjct: 338 EMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV- 396

Query: 92  TFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSG 151
                   +  ++ I++AS DRT+ VW+  T   V+ ++  +  + CL    RL V  S 
Sbjct: 397 --------DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSS 448

Query: 152 GNDLCVWNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD 211
            N + +W+ +     +     +  +  +    K  V  A   ++ ++ LVA  +      
Sbjct: 449 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAG 508

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWDALD 252
            L ++ L++H   +  L   ++   V+ SH   ++IWD L+
Sbjct: 509 TLCLRTLVEHSGRVFRL-QFDEFQIVSSSHDDTILIWDFLN 548



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 65/322 (20%), Positives = 121/322 (37%), Gaps = 44/322 (13%)

Query: 48  FLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLIL 107
           + +Q DD +  S   D  + +W+  T E    L GHT  +  +         +   ++I+
Sbjct: 271 YCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCL---------QYDERVII 321

Query: 108 TASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWN--RKLDLL 165
           T S+D TV VWD +T   +  +      V  L     + V  S    + VW+     D+ 
Sbjct: 322 TGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDIT 381

Query: 166 CKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD--ILEVKRLLDHQD 223
            +   +       +V+     +V+A G   I             W+    E  R L+   
Sbjct: 382 LRRVLVGHRAAVNVVDFDDKYIVSASGDRTI-----------KVWNTSTCEFVRTLNGHK 430

Query: 224 NILSLINVNDLSFVTGSHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSND 283
             ++ +   D   V+GS    + +WD       A  R        L+  +E+  C + ++
Sbjct: 431 RGIACLQYRDRLVVSGSSDNTIRLWDI---ECGACLR-------VLEGHEELVRCIRFDN 480

Query: 284 ISIHHFTCDEE----NVFAAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLIS 339
             I     D +    ++ AA+       +L ++ ++      H   V  + +    Q++S
Sbjct: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV-----EHSGRVFRL-QFDEFQIVS 534

Query: 340 CSEDGSVRIWELREKQQLAAEP 361
            S D ++ IW+        AEP
Sbjct: 535 SSHDDTILIWDFLNDPAAQAEP 556



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 12/116 (10%)

Query: 322 HDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAEPVPTGF---FNMWGFGR---V 375
           H   VLH+ R  N  +++CS+D S+ +W++     +    V  G     N+  F     V
Sbjct: 346 HCEAVLHL-RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIV 404

Query: 376 SKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
           S    + +K    N ++C  E +  L GH   +   L + D  +V+ S+D+ I LW
Sbjct: 405 SASGDRTIKVW--NTSTC--EFVRTLNGHKRGIAC-LQYRDRLVVSGSSDNTIRLW 455



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 14/135 (10%)

Query: 308 SLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQL-----AAEPV 362
           +L+ KR++    T H  +VL + +   R +I+ S D +VR+W++   + L       E V
Sbjct: 296 TLECKRIL----TGHTGSVLCL-QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV 350

Query: 363 PTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTC 422
               FN       SK  S  V    + A+   + L   L+GH ++V + + F+D  +V+ 
Sbjct: 351 LHLRFNNGMMVTCSKDRSIAV---WDMASPTDITLRRVLVGHRAAVNV-VDFDDKYIVSA 406

Query: 423 SADHLIILWKNGERE 437
           S D  I +W     E
Sbjct: 407 SGDRTIKVWNTSTCE 421


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 45/221 (20%), Positives = 93/221 (42%), Gaps = 13/221 (5%)

Query: 35  ELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLL---ELNGHTQKITAII 91
           E+L    HH      ++ ++    +   D  + VW+  +   +     L GH   +  + 
Sbjct: 374 EMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV- 432

Query: 92  TFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSG 151
                   +  ++ I++AS DRT+ VW+  T   V+ ++  +  + CL    RL V  S 
Sbjct: 433 --------DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSS 484

Query: 152 GNDLCVWNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD 211
            N + +W+ +     +     +  +  +    K  V  A   ++ ++ LVA  +      
Sbjct: 485 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAG 544

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWDALD 252
            L ++ L++H   +  L   ++   V+ SH   ++IWD L+
Sbjct: 545 TLCLRTLVEHSGRVFRL-QFDEFQIVSSSHDDTILIWDFLN 584



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 65/322 (20%), Positives = 121/322 (37%), Gaps = 44/322 (13%)

Query: 48  FLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLIL 107
           + +Q DD +  S   D  + +W+  T E    L GHT  +  +         +   ++I+
Sbjct: 307 YCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCL---------QYDERVII 357

Query: 108 TASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWN--RKLDLL 165
           T S+D TV VWD +T   +  +      V  L     + V  S    + VW+     D+ 
Sbjct: 358 TGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDIT 417

Query: 166 CKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD--ILEVKRLLDHQD 223
            +   +       +V+     +V+A G   I             W+    E  R L+   
Sbjct: 418 LRRVLVGHRAAVNVVDFDDKYIVSASGDRTI-----------KVWNTSTCEFVRTLNGHK 466

Query: 224 NILSLINVNDLSFVTGSHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSND 283
             ++ +   D   V+GS    + +WD       A  R        L+  +E+  C + ++
Sbjct: 467 RGIACLQYRDRLVVSGSSDNTIRLWDI---ECGACLR-------VLEGHEELVRCIRFDN 516

Query: 284 ISIHHFTCDEE----NVFAAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLIS 339
             I     D +    ++ AA+       +L ++ ++      H   V  + +    Q++S
Sbjct: 517 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV-----EHSGRVFRL-QFDEFQIVS 570

Query: 340 CSEDGSVRIWELREKQQLAAEP 361
            S D ++ IW+        AEP
Sbjct: 571 SSHDDTILIWDFLNDPAAQAEP 592



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 12/116 (10%)

Query: 322 HDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAEPVPTGF---FNMWGFGR---V 375
           H   VLH+ R  N  +++CS+D S+ +W++     +    V  G     N+  F     V
Sbjct: 382 HCEAVLHL-RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIV 440

Query: 376 SKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
           S    + +K    N ++C  E +  L GH   +   L + D  +V+ S+D+ I LW
Sbjct: 441 SASGDRTIKVW--NTSTC--EFVRTLNGHKRGIAC-LQYRDRLVVSGSSDNTIRLW 491



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 14/135 (10%)

Query: 308 SLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQL-----AAEPV 362
           +L+ KR++    T H  +VL + +   R +I+ S D +VR+W++   + L       E V
Sbjct: 332 TLECKRIL----TGHTGSVLCL-QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV 386

Query: 363 PTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTC 422
               FN       SK  S  V    + A+   + L   L+GH ++V + + F+D  +V+ 
Sbjct: 387 LHLRFNNGMMVTCSKDRSIAV---WDMASPTDITLRRVLVGHRAAVNV-VDFDDKYIVSA 442

Query: 423 SADHLIILWKNGERE 437
           S D  I +W     E
Sbjct: 443 SGDRTIKVWNTSTCE 457


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 43/221 (19%), Positives = 91/221 (41%), Gaps = 13/221 (5%)

Query: 35  ELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLL---ELNGHTQKITAII 91
           E+L    HH+     ++  +    +   D  + VW+  +   +     L GH   +  + 
Sbjct: 311 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV- 369

Query: 92  TFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSG 151
                   +  ++ I++AS DRT+ VW   T   V+ ++  +  + CL    RL V  S 
Sbjct: 370 --------DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSS 421

Query: 152 GNDLCVWNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD 211
            N + +W+ +     +     +  +  +    K  V  A   ++ ++ L A  +      
Sbjct: 422 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 481

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWDALD 252
            L ++ L++H   +  L   ++   ++ SH   ++IWD L+
Sbjct: 482 TLCLRTLVEHSGRVFRL-QFDEFQIISSSHDDTILIWDFLN 521



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 46/204 (22%), Positives = 80/204 (39%), Gaps = 20/204 (9%)

Query: 48  FLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLIL 107
           + +Q DD +  S   D  + +W+  + E L  L GHT  +  +         +   ++I+
Sbjct: 244 YCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL---------QYDERVIV 294

Query: 108 TASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWN--RKLDLL 165
           T S+D TV VWD +T   +  +      V  L     L V  S    + VW+     D+ 
Sbjct: 295 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDIT 354

Query: 166 CKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNI 225
            +   +       +V+     +V+A G   I     +  E         V+ L  H+  I
Sbjct: 355 LRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCE--------FVRTLNGHKRGI 406

Query: 226 LSLINVNDLSFVTGSHVGELIIWD 249
            + +   D   V+GS    + +WD
Sbjct: 407 -ACLQYRDRLVVSGSSDNTIRLWD 429



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 12/116 (10%)

Query: 322 HDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAEPVPTGF---FNMWGFGR---V 375
           H+  VLH+ R  N  +++CS+D S+ +W++     +    V  G     N+  F     V
Sbjct: 319 HNEAVLHL-RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIV 377

Query: 376 SKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
           S    + +K      ++ + E +  L GH   +   L + D  +V+ S+D+ I LW
Sbjct: 378 SASGDRTIKVW----STSTCEFVRTLNGHKRGIAC-LQYRDRLVVSGSSDNTIRLW 428



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 51/158 (32%)

Query: 278 CQKSNDISIHHFTCDEENVFAAVGRGLYVYSLQM--KRVIACQK--TAHDSNVLHVARLP 333
           C+  N   ++    D+E + +    GL   S+++  K  + C K  T H  +VL + +  
Sbjct: 235 CRSENSKGVYCLQYDDEKIIS----GLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYD 289

Query: 334 NRQLISCSEDGSVRIWELREKQQLAAEPVPTGFFNMWGFGRVSKQASQPVKKQQENATSC 393
            R +++ S D +VR+W+           V TG                            
Sbjct: 290 ERVIVTGSSDSTVRVWD-----------VNTG---------------------------- 310

Query: 394 SLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
             E++  LI H+ +V + L F +  +VTCS D  I +W
Sbjct: 311 --EVLNTLIHHNEAV-LHLRFSNGLMVTCSKDRSIAVW 345


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 43/221 (19%), Positives = 91/221 (41%), Gaps = 13/221 (5%)

Query: 35  ELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLL---ELNGHTQKITAII 91
           E+L    HH+     ++  +    +   D  + VW+  +   +     L GH   +  + 
Sbjct: 277 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV- 335

Query: 92  TFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSG 151
                   +  ++ I++AS DRT+ VW   T   V+ ++  +  + CL    RL V  S 
Sbjct: 336 --------DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSS 387

Query: 152 GNDLCVWNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD 211
            N + +W+ +     +     +  +  +    K  V  A   ++ ++ L A  +      
Sbjct: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 447

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWDALD 252
            L ++ L++H   +  L   ++   ++ SH   ++IWD L+
Sbjct: 448 TLCLRTLVEHSGRVFRL-QFDEFQIISSSHDDTILIWDFLN 487



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 46/204 (22%), Positives = 80/204 (39%), Gaps = 20/204 (9%)

Query: 48  FLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLIL 107
           + +Q DD +  S   D  + +W+  + E L  L GHT  +  +         +   ++I+
Sbjct: 210 YCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL---------QYDERVIV 260

Query: 108 TASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWN--RKLDLL 165
           T S+D TV VWD +T   +  +      V  L     L V  S    + VW+     D+ 
Sbjct: 261 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDIT 320

Query: 166 CKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNI 225
            +   +       +V+     +V+A G   I     +  E         V+ L  H+  I
Sbjct: 321 LRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCE--------FVRTLNGHKRGI 372

Query: 226 LSLINVNDLSFVTGSHVGELIIWD 249
            + +   D   V+GS    + +WD
Sbjct: 373 -ACLQYRDRLVVSGSSDNTIRLWD 395



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 12/116 (10%)

Query: 322 HDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAEPVPTGF---FNMWGFGR---V 375
           H+  VLH+ R  N  +++CS+D S+ +W++     +    V  G     N+  F     V
Sbjct: 285 HNEAVLHL-RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIV 343

Query: 376 SKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
           S    + +K      ++ + E +  L GH   +   L + D  +V+ S+D+ I LW
Sbjct: 344 SASGDRTIKVW----STSTCEFVRTLNGHKRGIAC-LQYRDRLVVSGSSDNTIRLW 394



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 51/158 (32%)

Query: 278 CQKSNDISIHHFTCDEENVFAAVGRGLYVYSLQM--KRVIACQK--TAHDSNVLHVARLP 333
           C+  N   ++    D+E + +    GL   S+++  K  + C K  T H  +VL + +  
Sbjct: 201 CRSENSKGVYCLQYDDEKIIS----GLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYD 255

Query: 334 NRQLISCSEDGSVRIWELREKQQLAAEPVPTGFFNMWGFGRVSKQASQPVKKQQENATSC 393
            R +++ S D +VR+W+           V TG                            
Sbjct: 256 ERVIVTGSSDSTVRVWD-----------VNTG---------------------------- 276

Query: 394 SLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
             E++  LI H+ +V + L F +  +VTCS D  I +W
Sbjct: 277 --EVLNTLIHHNEAV-LHLRFSNGLMVTCSKDRSIAVW 311


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 43/221 (19%), Positives = 91/221 (41%), Gaps = 13/221 (5%)

Query: 35  ELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLL---ELNGHTQKITAII 91
           E+L    HH+     ++  +    +   D  + VW+  +   +     L GH   +  + 
Sbjct: 298 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV- 356

Query: 92  TFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSG 151
                   +  ++ I++AS DRT+ VW   T   V+ ++  +  + CL    RL V  S 
Sbjct: 357 --------DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSS 408

Query: 152 GNDLCVWNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD 211
            N + +W+ +     +     +  +  +    K  V  A   ++ ++ L A  +      
Sbjct: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 468

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWDALD 252
            L ++ L++H   +  L   ++   ++ SH   ++IWD L+
Sbjct: 469 TLCLRTLVEHSGRVFRL-QFDEFQIISSSHDDTILIWDFLN 508



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 46/204 (22%), Positives = 80/204 (39%), Gaps = 20/204 (9%)

Query: 48  FLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLIL 107
           + +Q DD +  S   D  + +W+  + E L  L GHT  +  +         +   ++I+
Sbjct: 231 YCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL---------QYDERVIV 281

Query: 108 TASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWN--RKLDLL 165
           T S+D TV VWD +T   +  +      V  L     L V  S    + VW+     D+ 
Sbjct: 282 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDIT 341

Query: 166 CKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNI 225
            +   +       +V+     +V+A G   I     +  E         V+ L  H+  I
Sbjct: 342 LRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCE--------FVRTLNGHKRGI 393

Query: 226 LSLINVNDLSFVTGSHVGELIIWD 249
            + +   D   V+GS    + +WD
Sbjct: 394 -ACLQYRDRLVVSGSSDNTIRLWD 416



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 12/116 (10%)

Query: 322 HDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAEPVPTGF---FNMWGFGR---V 375
           H+  VLH+ R  N  +++CS+D S+ +W++     +    V  G     N+  F     V
Sbjct: 306 HNEAVLHL-RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIV 364

Query: 376 SKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
           S    + +K      ++ + E +  L GH   +   L + D  +V+ S+D+ I LW
Sbjct: 365 SASGDRTIKVW----STSTCEFVRTLNGHKRGIAC-LQYRDRLVVSGSSDNTIRLW 415



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 51/158 (32%)

Query: 278 CQKSNDISIHHFTCDEENVFAAVGRGLYVYSLQM--KRVIACQK--TAHDSNVLHVARLP 333
           C+  N   ++    D+E + +    GL   S+++  K  + C K  T H  +VL + +  
Sbjct: 222 CRSENSKGVYCLQYDDEKIIS----GLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYD 276

Query: 334 NRQLISCSEDGSVRIWELREKQQLAAEPVPTGFFNMWGFGRVSKQASQPVKKQQENATSC 393
            R +++ S D +VR+W+           V TG                            
Sbjct: 277 ERVIVTGSSDSTVRVWD-----------VNTG---------------------------- 297

Query: 394 SLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILW 431
             E++  LI H+ +V + L F +  +VTCS D  I +W
Sbjct: 298 --EVLNTLIHHNEAV-LHLRFSNGLMVTCSKDRSIAVW 332


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 7/102 (6%)

Query: 53  DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
           D  +  + G D  VVV++  + + L  L GHT+K+T+++  PS         L+ +AS D
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPS-------QDLVFSASPD 285

Query: 113 RTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND 154
            T+ +W       VQ +   +S V  L++    D  LS  +D
Sbjct: 286 ATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDD 327


>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
           sapiens]
          Length = 475

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 48/251 (19%), Positives = 102/251 (40%), Gaps = 16/251 (6%)

Query: 6   IGGGREPQGLAEKSPLQTIGEEQTQNPYT-ELLVLKAHH-DIVRFLVQLDDYRFASAGDD 63
           + G  +   L ++  LQ +  ++ Q P + ++ VL+ H   I   +V  DD    SA  D
Sbjct: 108 VAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKD 167

Query: 64  GIVVVWNAQTGEKLLEL----NGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWD 119
             ++ W+ ++G KL  +     G   K     +     +     + + +    + +++W+
Sbjct: 168 CSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWE 227

Query: 120 GDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND--LCVWNRKLDLLCKTSHLSDTGIS 177
             + + +   +  +  V  L   +      S  +D  + VWN   +   +T       ++
Sbjct: 228 AQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVA 287

Query: 178 ALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFV 237
           AL  + + C V A G++  +     P E  L +          HQ +I  +  +N+   V
Sbjct: 288 ALDALSRECCVTAGGRDGTVRVWKIPEESQLVF--------YGHQGSIDCIHLINEEHMV 339

Query: 238 TGSHVGELIIW 248
           +G+  G + +W
Sbjct: 340 SGADDGSVALW 350


>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
          Length = 367

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 7/96 (7%)

Query: 41  AHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCE 100
           AH D V  +  L+     S G D  VV +N +TG  +    GH  +IT +       +C 
Sbjct: 60  AHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKV-------ACI 112

Query: 101 EKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTV 136
            K+    +AS DR V++WD   + Q ++  C  + V
Sbjct: 113 PKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMV 148


>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
          Length = 366

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 7/96 (7%)

Query: 41  AHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCE 100
           AH D V  +  L+     S G D  VV +N +TG  +    GH  +IT +       +C 
Sbjct: 59  AHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKV-------ACI 111

Query: 101 EKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTV 136
            K+    +AS DR V++WD   + Q ++  C  + V
Sbjct: 112 PKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMV 147


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 46/214 (21%), Positives = 83/214 (38%), Gaps = 45/214 (21%)

Query: 54  DYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADR 113
           D +  +A  DG   +W+ ++G+ L   +GH   +  +   PS     E     ++   D+
Sbjct: 165 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS-----ETGNTFVSGGCDK 219

Query: 114 TVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSD 173
             +VWD  + + VQ     +S +  +      D + SG                    SD
Sbjct: 220 KAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG--------------------SD 259

Query: 174 TGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLE---------------WDILEVKR- 217
                L ++  +  VA   KE IIF   +  + SL                WD+L+  R 
Sbjct: 260 DATCRLYDLRADREVAIYSKESIIFG-ASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318

Query: 218 --LLDHQDNILSL-INVNDLSFVTGSHVGELIIW 248
             L  H++ + +L ++ +  +F +GS    L +W
Sbjct: 319 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352



 Score = 29.3 bits (64), Expect = 7.8
 Identities = 15/51 (29%), Positives = 28/51 (54%), Gaps = 7/51 (13%)

Query: 80  LNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRIS 130
           L GH  K+        ++ C++K +++ ++S D  VIVWD  TT +   ++
Sbjct: 59  LKGHGNKVLC------MDWCKDKRRIV-SSSQDGKVIVWDSFTTNKEHAVT 102


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 46/214 (21%), Positives = 83/214 (38%), Gaps = 45/214 (21%)

Query: 54  DYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADR 113
           D +  +A  DG   +W+ ++G+ L   +GH   +  +   PS     E     ++   D+
Sbjct: 207 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS-----ETGNTFVSGGCDK 261

Query: 114 TVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSD 173
             +VWD  + + VQ     +S +  +      D + SG                    SD
Sbjct: 262 KAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG--------------------SD 301

Query: 174 TGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLE---------------WDILEVKR- 217
                L ++  +  VA   KE IIF   +  + SL                WD+L+  R 
Sbjct: 302 DATCRLYDLRADREVAIYSKESIIFG-ASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360

Query: 218 --LLDHQDNILSL-INVNDLSFVTGSHVGELIIW 248
             L  H++ + +L ++ +  +F +GS    L +W
Sbjct: 361 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 29.3 bits (64), Expect = 7.8
 Identities = 15/51 (29%), Positives = 28/51 (54%), Gaps = 7/51 (13%)

Query: 80  LNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRIS 130
           L GH  K+        ++ C++K +++ ++S D  VIVWD  TT +   ++
Sbjct: 101 LKGHGNKVLC------MDWCKDKRRIV-SSSQDGKVIVWDSFTTNKEHAVT 144


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 8/103 (7%)

Query: 37  LVLKAHHDIVRFLVQLDD-YRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           LV++ H D V      +D  R AS G D  + V+ A+TGEKLLE+  H  ++        
Sbjct: 609 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC----- 663

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKC 138
             +    ++ I T S D+ V +W+  T   V         V C
Sbjct: 664 --AFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNC 704



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 55/244 (22%), Positives = 93/244 (38%), Gaps = 49/244 (20%)

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELI-IWDALDWTMQAYERNFWDPSPQLD 270
           +LE+K    H+D +L      D  F+    V + + IW+++   +             + 
Sbjct: 650 LLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL-------------VH 693

Query: 271 TQQEIKLCQKSNDISIHHFTCDEENVFAAVGRG---LYVYSLQMKRVIACQKT--AHDSN 325
           T  E      S  ++  HFT    ++  A G     L ++ L  K    C+ T   H ++
Sbjct: 694 TYDE-----HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE---CRNTMFGHTNS 745

Query: 326 VLHVARLPNRQLI-SCSEDGSVRIWELREKQQLAAEPVPTGFFNM--------------- 369
           V H    P+ +L+ SCS DG++++W+     +  +  V   F N+               
Sbjct: 746 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCS 805

Query: 370 WGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFED-HGLVTCSADHLI 428
           W         +   K    N  S S   + D  GH S V   ++  D    +T S D  I
Sbjct: 806 WSADGARIMVAAKNKIFLWNTDSRS--KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 863

Query: 429 ILWK 432
            LW+
Sbjct: 864 RLWE 867



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 9/84 (10%)

Query: 53   DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
            D+    S+ DD  + VWN Q  +K + L GH + +              KN  +L+ S D
Sbjct: 971  DEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLL--------KNSRLLSWSFD 1021

Query: 113  RTVIVWDGDTTRQVQRISCFQSTV 136
             TV VW+  T  + +   C Q TV
Sbjct: 1022 GTVKVWNIITGNKEKDFVCHQGTV 1045



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 14/144 (9%)

Query: 37   LVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSL 96
            + L+ H + V+    L + R  S   DG V VWN  TG K  +   H   +         
Sbjct: 995  IFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL-------- 1046

Query: 97   ESCEEKNQL--ILTASADRTVIVWDGDTTRQVQRISCFQSTVKC--LTVLQRLDVWLSGG 152
             SC+  +      + SAD+T  +W  D    +  +      V+C   +V   L       
Sbjct: 1047 -SCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDN 1105

Query: 153  NDLCVWN-RKLDLLCKTSHLSDTG 175
             ++ +WN    +LL   + LS+ G
Sbjct: 1106 GEIRIWNVSNGELLHLCAPLSEEG 1129



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 83/393 (21%), Positives = 140/393 (35%), Gaps = 88/393 (22%)

Query: 35   ELLVLKAHHDIVRFLVQLDDYRF-ASAGDDGIVVVWNAQTGE------------------ 75
            +LL +KAH D V       D RF A+   D  V +WN+ TGE                  
Sbjct: 649  KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 708

Query: 76   -----------------KLLELNGHTQKITAIITFPSLESCE--EKNQLILTASADRTVI 116
                             KL +LN    + T      S+  C     ++L+ + SAD T+ 
Sbjct: 709  NSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 768

Query: 117  VWDGDTTRQVQRISCFQSTVKC------LTVLQRLDVWLSGG--------NDLCVWN--- 159
            +WD  +  + + I+  Q  +        + V+ +   W + G        N + +WN   
Sbjct: 769  LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDS 828

Query: 160  RKLDLLCKTSHLS------------------DTGISALVEIPKNCVVAAVGKELIIFRLV 201
            R     C+  HLS                  D     L E  K C  +AV         +
Sbjct: 829  RSKVADCR-GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAV---------M 878

Query: 202  APTEGSLEWDILEVKRLLDHQDNILSLIN--VNDLSFVTGSHVGELIIWDALDWTMQAYE 259
               E  + +   EV  L       L LIN     + ++T + V    +   L +     E
Sbjct: 879  LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDE 938

Query: 260  RNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAVGRG-LYVYSLQMKRVIACQ 318
                +    ++ +      Q    +    FT DE+ + ++     + V++ Q+ + I  +
Sbjct: 939  NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR 998

Query: 319  KTAHDSNVLHVARLPNRQLISCSEDGSVRIWEL 351
               H   V     L N +L+S S DG+V++W +
Sbjct: 999  --GHQETVKDFRLLKNSRLLSWSFDGTVKVWNI 1029


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 8/103 (7%)

Query: 37  LVLKAHHDIVRFLVQLDD-YRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           LV++ H D V      +D  R AS G D  + V+ A+TGEKLLE+  H  ++        
Sbjct: 609 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC----- 663

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKC 138
             +    ++ I T S D+ V +W+  T   V         V C
Sbjct: 664 --AFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNC 704



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 31/165 (18%)

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELI-IWDALDWTMQAYERNFWDPSPQLD 270
           +LE+K    H+D +L      D  F+    V + + IW+++   +             + 
Sbjct: 650 LLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL-------------VH 693

Query: 271 TQQEIKLCQKSNDISIHHFTCDEENVFAAVGRG---LYVYSLQMKRVIACQKT--AHDSN 325
           T  E      S  ++  HFT    ++  A G     L ++ L  K    C+ T   H ++
Sbjct: 694 TYDE-----HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE---CRNTMFGHTNS 745

Query: 326 VLHVARLPNRQLI-SCSEDGSVRIWELREKQQLAAEPVPTGFFNM 369
           V H    P+ +L+ SCS DG++++W+     +  +  V   F N+
Sbjct: 746 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 9/84 (10%)

Query: 53   DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
            D+    S+ DD  + VWN Q  +K + L GH + +              KN  +L+ S D
Sbjct: 1014 DEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLL--------KNSRLLSWSFD 1064

Query: 113  RTVIVWDGDTTRQVQRISCFQSTV 136
             TV VW+  T  + +   C Q TV
Sbjct: 1065 GTVKVWNIITGNKEKDFVCHQGTV 1088



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 14/144 (9%)

Query: 37   LVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSL 96
            + L+ H + V+    L + R  S   DG V VWN  TG K  +   H   +         
Sbjct: 1038 IFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL-------- 1089

Query: 97   ESCEEKNQL--ILTASADRTVIVWDGDTTRQVQRISCFQSTVKC--LTVLQRLDVWLSGG 152
             SC+  +      + SAD+T  +W  D    +  +      V+C   +V   L       
Sbjct: 1090 -SCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDN 1148

Query: 153  NDLCVWN-RKLDLLCKTSHLSDTG 175
             ++ +WN    +LL   + LS+ G
Sbjct: 1149 GEIRIWNVSNGELLHLCAPLSEEG 1172



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/64 (28%), Positives = 34/64 (53%), Gaps = 3/64 (4%)

Query: 289  FTCDEENVFAAVGRG-LYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVR 347
            FT DE+ + ++     + V++ Q+ + I  +   H   V     L N +L+S S DG+V+
Sbjct: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLR--GHQETVKDFRLLKNSRLLSWSFDGTVK 1068

Query: 348  IWEL 351
            +W +
Sbjct: 1069 VWNI 1072


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 8/103 (7%)

Query: 37  LVLKAHHDIVRFLVQLDD-YRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           LV++ H D V      +D  R AS G D  + V+ A+TGEKLLE+  H  ++        
Sbjct: 598 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC----- 652

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKC 138
             +    ++ I T S D+ V +W+  T   V         V C
Sbjct: 653 --AFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNC 693



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 55/244 (22%), Positives = 93/244 (38%), Gaps = 49/244 (20%)

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELI-IWDALDWTMQAYERNFWDPSPQLD 270
           +LE+K    H+D +L      D  F+    V + + IW+++   +             + 
Sbjct: 639 LLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL-------------VH 682

Query: 271 TQQEIKLCQKSNDISIHHFTCDEENVFAAVGRG---LYVYSLQMKRVIACQKT--AHDSN 325
           T  E      S  ++  HFT    ++  A G     L ++ L  K    C+ T   H ++
Sbjct: 683 TYDE-----HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE---CRNTMFGHTNS 734

Query: 326 VLHVARLPNRQLI-SCSEDGSVRIWELREKQQLAAEPVPTGFFNM--------------- 369
           V H    P+ +L+ SCS DG++++W+     +  +  V   F N+               
Sbjct: 735 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCS 794

Query: 370 WGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFED-HGLVTCSADHLI 428
           W         +   K    N  S S   + D  GH S V   ++  D    +T S D  I
Sbjct: 795 WSADGARIMVAAKNKIFLWNTDSRS--KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 852

Query: 429 ILWK 432
            LW+
Sbjct: 853 RLWE 856



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 9/84 (10%)

Query: 53   DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
            D+    S+ DD  + VWN Q  +K + L GH + +              KN  +L+ S D
Sbjct: 960  DEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLL--------KNSRLLSWSFD 1010

Query: 113  RTVIVWDGDTTRQVQRISCFQSTV 136
             TV VW+  T  + +   C Q TV
Sbjct: 1011 GTVKVWNIITGNKEKDFVCHQGTV 1034



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 14/144 (9%)

Query: 37   LVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSL 96
            + L+ H + V+    L + R  S   DG V VWN  TG K  +   H   +         
Sbjct: 984  IFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL-------- 1035

Query: 97   ESCEEKNQL--ILTASADRTVIVWDGDTTRQVQRISCFQSTVKC--LTVLQRLDVWLSGG 152
             SC+  +      + SAD+T  +W  D    +  +      V+C   +V   L       
Sbjct: 1036 -SCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDN 1094

Query: 153  NDLCVWN-RKLDLLCKTSHLSDTG 175
             ++ +WN    +LL   + LS+ G
Sbjct: 1095 GEIRIWNVSNGELLHLCAPLSEEG 1118



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 83/393 (21%), Positives = 140/393 (35%), Gaps = 88/393 (22%)

Query: 35   ELLVLKAHHDIVRFLVQLDDYRF-ASAGDDGIVVVWNAQTGE------------------ 75
            +LL +KAH D V       D RF A+   D  V +WN+ TGE                  
Sbjct: 638  KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 697

Query: 76   -----------------KLLELNGHTQKITAIITFPSLESCE--EKNQLILTASADRTVI 116
                             KL +LN    + T      S+  C     ++L+ + SAD T+ 
Sbjct: 698  NSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 757

Query: 117  VWDGDTTRQVQRISCFQSTVKC------LTVLQRLDVWLSGG--------NDLCVWN--- 159
            +WD  +  + + I+  Q  +        + V+ +   W + G        N + +WN   
Sbjct: 758  LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDS 817

Query: 160  RKLDLLCKTSHLS------------------DTGISALVEIPKNCVVAAVGKELIIFRLV 201
            R     C+  HLS                  D     L E  K C  +AV         +
Sbjct: 818  RSKVADCR-GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAV---------M 867

Query: 202  APTEGSLEWDILEVKRLLDHQDNILSLIN--VNDLSFVTGSHVGELIIWDALDWTMQAYE 259
               E  + +   EV  L       L LIN     + ++T + V    +   L +     E
Sbjct: 868  LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDE 927

Query: 260  RNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAVGRG-LYVYSLQMKRVIACQ 318
                +    ++ +      Q    +    FT DE+ + ++     + V++ Q+ + I  +
Sbjct: 928  NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR 987

Query: 319  KTAHDSNVLHVARLPNRQLISCSEDGSVRIWEL 351
               H   V     L N +L+S S DG+V++W +
Sbjct: 988  --GHQETVKDFRLLKNSRLLSWSFDGTVKVWNI 1018


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
           sapiens]
          Length = 1237

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 8/103 (7%)

Query: 37  LVLKAHHDIVRFLVQLDD-YRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPS 95
           LV++ H D V      +D  R AS G D  + V+ A+TGEKLLE+  H  ++        
Sbjct: 598 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC----- 652

Query: 96  LESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKC 138
             +    ++ I T S D+ V +W+  T   V         V C
Sbjct: 653 --AFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNC 693



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 31/165 (18%)

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELI-IWDALDWTMQAYERNFWDPSPQLD 270
           +LE+K    H+D +L      D  F+    V + + IW+++   +             + 
Sbjct: 639 LLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL-------------VH 682

Query: 271 TQQEIKLCQKSNDISIHHFTCDEENVFAAVGRG---LYVYSLQMKRVIACQKT--AHDSN 325
           T  E      S  ++  HFT    ++  A G     L ++ L  K    C+ T   H ++
Sbjct: 683 TYDE-----HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE---CRNTMFGHTNS 734

Query: 326 VLHVARLPNRQLI-SCSEDGSVRIWELREKQQLAAEPVPTGFFNM 369
           V H    P+ +L+ SCS DG++++W+     +  +  V   F N+
Sbjct: 735 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 9/84 (10%)

Query: 53   DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
            D+    S+ DD  + VWN Q  +K + L GH + +              KN  +L+ S D
Sbjct: 1003 DEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLL--------KNSRLLSWSFD 1053

Query: 113  RTVIVWDGDTTRQVQRISCFQSTV 136
             TV VW+  T  + +   C Q TV
Sbjct: 1054 GTVKVWNIITGNKEKDFVCHQGTV 1077



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 14/144 (9%)

Query: 37   LVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSL 96
            + L+ H + V+    L + R  S   DG V VWN  TG K  +   H   +         
Sbjct: 1027 IFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL-------- 1078

Query: 97   ESCEEKNQL--ILTASADRTVIVWDGDTTRQVQRISCFQSTVKC--LTVLQRLDVWLSGG 152
             SC+  +      + SAD+T  +W  D    +  +      V+C   +V   L       
Sbjct: 1079 -SCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDN 1137

Query: 153  NDLCVWN-RKLDLLCKTSHLSDTG 175
             ++ +WN    +LL   + LS+ G
Sbjct: 1138 GEIRIWNVSNGELLHLCAPLSEEG 1161



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/64 (28%), Positives = 34/64 (53%), Gaps = 3/64 (4%)

Query: 289  FTCDEENVFAAVGRG-LYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVR 347
            FT DE+ + ++     + V++ Q+ + I  +   H   V     L N +L+S S DG+V+
Sbjct: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLR--GHQETVKDFRLLKNSRLLSWSFDGTVK 1057

Query: 348  IWEL 351
            +W +
Sbjct: 1058 VWNI 1061


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 7/69 (10%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           A+   D    +W+ Q GE++  L GH+ +I ++       S       I+T S D TV+V
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL-------SFNTSGDRIITGSFDHTVVV 245

Query: 118 WDGDTTRQV 126
           WD DT R+V
Sbjct: 246 WDADTGRKV 254



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 35/115 (30%), Positives = 48/115 (41%), Gaps = 17/115 (14%)

Query: 35  ELLVLKAHH-DIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITF 93
           E+  L+ H  +I+         R  +   D  VVVW+A TG K+  L GH  +I      
Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI------ 264

Query: 94  PSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRI---------SCFQSTVKCL 139
            S  S      LILT S D+T  +WD    + V  +         SCF  T K +
Sbjct: 265 -SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLI 318



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 21/70 (30%), Positives = 37/70 (52%), Gaps = 7/70 (10%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           A+A  DG   +++A T + + +L GH  +I+ I       S   +   +LT S+D+T  +
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKI-------SFNPQGNHLLTGSSDKTARI 371

Query: 118 WDGDTTRQVQ 127
           WD  T + +Q
Sbjct: 372 WDAQTGQCLQ 381



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 7/60 (11%)

Query: 59  SAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVW 118
           +   D    +W+AQTG+ L  L GHT +I +        +   K  +++T S D T  +W
Sbjct: 362 TGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC-------AFNYKGNIVITGSKDNTCRIW 414



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 27/118 (22%), Positives = 45/118 (38%), Gaps = 7/118 (5%)

Query: 38  VLKAHH-DIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSL 96
           VLKAH   +    +      F +   D    +W+  +GE+L  L GH   + AI      
Sbjct: 87  VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI------ 140

Query: 97  ESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND 154
                    I T S D+T  +W  +T +         + + CL+   +  +  +G  D
Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 29/221 (13%)

Query: 39  LKAHHDIVRFLVQLDDYRFASAGD-DGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLE 97
           L+ H   V  +V   D +FA +G  DG + +W+  TG       GHT+ + ++       
Sbjct: 59  LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSV------- 111

Query: 98  SCEEKNQLILTASADRTVIVWD--GDTTRQVQRISCFQSTVKCLTVLQRLD--VWLSGGN 153
           +    N+ I++ S D+T+ +W+  G     VQ  S     V C+         + +S G 
Sbjct: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDES-HSEWVSCVRFSPNSSNPIIVSCGW 170

Query: 154 D--LCVWNRKLDLLCKTSHLSDTG-ISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEW 210
           D  + VWN   +   KT+H+  TG ++ +   P   + A+ GK+            ++ W
Sbjct: 171 DKLVKVWN-LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD----------GQAMLW 219

Query: 211 DILEVKRL--LDHQDNILSLINVNDLSFVTGSHVGELIIWD 249
           D+ E K L  LD  D I +L    +  ++  +    + IWD
Sbjct: 220 DLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWD 260



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 6/39 (15%)

Query: 80  LNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVW 118
           L GH   +T I T P          +IL+AS D+T+I+W
Sbjct: 11  LKGHNGWVTQIATTPQFPD------MILSASRDKTIIMW 43


>gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]
          Length = 480

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 13/94 (13%)

Query: 54  DYRFASAGDDGIVVVWNAQTG-------EKLLELNGHTQKITAIITFPSLESCEEKNQLI 106
           D   AS  +D  V +W    G       E LLEL+GH++++  +   P+       N ++
Sbjct: 100 DNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTT------NNIL 153

Query: 107 LTASADRTVIVWDGDTTRQVQRISCFQSTVKCLT 140
            +A  D  V++W+ D    V+ I C    + C++
Sbjct: 154 FSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMS 187



 Score = 33.1 bits (74), Expect = 0.54
 Identities = 17/34 (50%), Positives = 21/34 (61%), Gaps = 2/34 (5%)

Query: 322 HDSNVLHVARLP--NRQLISCSEDGSVRIWELRE 353
           H  NVL +   P  +  + SCSED SVRIWE+ E
Sbjct: 86  HQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPE 119


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 43/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)

Query: 56  RFASAGDDGIVVVWNAQTGEK---LLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
           R  +AG D I+ +W+    ++   +  +  HT  +  I+       C  K   +++AS+D
Sbjct: 44  RLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVL-----CCNGKT--LISASSD 96

Query: 113 RTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLS 172
            TV VW+      +  +   +  VK L   +  ++  S G D  ++   ++ L   +  +
Sbjct: 97  TTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASN 156

Query: 173 DTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLE-WD---ILEVKRLLDHQDNILS- 227
           +T  ++ +   K+ + +    +L    +   TE  L  WD     ++ +L  H DN+ + 
Sbjct: 157 NTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKAL 216

Query: 228 LINVNDLSFVTGSHVGELIIW 248
           L+N +    ++GS  G + +W
Sbjct: 217 LLNRDGTQCLSGSSDGTIRLW 237



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 36/146 (24%), Positives = 62/146 (42%), Gaps = 5/146 (3%)

Query: 39  LKAHHDIVRFLVQLDDYRF-ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLE 97
           L+ H D V+ L    D    ASAG D  + +W+  T   L   N      +      S+ 
Sbjct: 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIY 172

Query: 98  SC--EEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND- 154
           S    +   +I++ S ++ + VWD  T  ++ ++      VK L + +     LSG +D 
Sbjct: 173 SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDG 232

Query: 155 -LCVWNRKLDLLCKTSHLSDTGISAL 179
            + +W+        T  + D G+ AL
Sbjct: 233 TIRLWSLGQQRCIATYRVHDEGVWAL 258



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 7/96 (7%)

Query: 59  SAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVW 118
           S   + ++ VW+ +T  KL++L GHT  + A++       C       L+ S+D T+ +W
Sbjct: 185 SGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQC-------LSGSSDGTIRLW 237

Query: 119 DGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND 154
                R +         V  L V        SGG D
Sbjct: 238 SLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRD 273


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 48/305 (15%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           AS+  D ++++W A  G+    L GH  +I+ +       +    +  +++AS D+T+ +
Sbjct: 57  ASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV-------AWSSDSSRLVSASDDKTLKL 109

Query: 118 WDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND--LCVWNRKLDLLCKTSHLSDTG 175
           WD  + + ++ +    + V C       ++ +SG  D  + +W  K     KT       
Sbjct: 110 WDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDP 169

Query: 176 ISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLE-----WDILE---VKRLLDHQDNILS 227
           +SA   +  NC  + +              GS +     WD      +K L+D  DN   
Sbjct: 170 VSA---VHFNCSGSLI------------VSGSYDGLCRIWDAASGQCLKTLVD-DDN--- 210

Query: 228 LINVNDLSFVTGSHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIH 287
                 +SFV  S  G+ I+   LD T++ ++ +           +  K C  +N     
Sbjct: 211 ----PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN----F 262

Query: 288 HFTCDEENVFAAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCS---EDG 344
             T  +  V  +    +Y+++LQ K ++  +   H   V+  A  P   LI+ +    D 
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQ-KLQGHTDVVISAACHPTENLIASAALENDK 321

Query: 345 SVRIW 349
           ++++W
Sbjct: 322 TIKLW 326



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 9/118 (7%)

Query: 53  DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
           D  R  SA DD  + +W+ ++G+ L  L GH+  +      P        + LI++ S D
Sbjct: 94  DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP-------PSNLIISGSFD 146

Query: 113 RTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND-LC-VWNRKLDLLCKT 168
            TV +W+  T + ++ +S     V  +       + +SG  D LC +W+       KT
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 41/179 (22%), Positives = 74/179 (41%), Gaps = 27/179 (15%)

Query: 80  LNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVW---DGDTTRQVQRISCFQSTV 136
           L GHT+ ++++   P+        + + ++SADR +I+W   DG   + +   +   S V
Sbjct: 37  LVGHTEAVSSVKFSPN-------GEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89

Query: 137 KCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKT-SHLSDTGISALVEIPKNCVVAAVGKEL 195
              +   RL V  S    L +W+ +     KT    S+         P N +++    E 
Sbjct: 90  AWSSDSSRL-VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDET 148

Query: 196 IIFRLVAPTEGSLEWDILE---VKRLLDHQDNILSL-INVNDLSFVTGSHVGELIIWDA 250
           +             W++     +K L  H D + ++  N +    V+GS+ G   IWDA
Sbjct: 149 VKI-----------WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDA 196


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 60/298 (20%), Positives = 126/298 (42%), Gaps = 32/298 (10%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           AS+  D ++ +W A  G+    ++GH   I+ +       +    + L+++AS D+T+ +
Sbjct: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDV-------AWSSDSNLLVSASDDKTLKI 113

Query: 118 WDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND--LCVWNRKLDLLCKTSHLSDTG 175
           WD  + + ++ +    + V C     + ++ +SG  D  + +W+ K     KT       
Sbjct: 114 WDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 173

Query: 176 ISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLS 235
           +SA V   ++  +        + R+     G        +K L+D  DN         +S
Sbjct: 174 VSA-VHFNRDGSLIVSSSYDGLCRIWDTASGQC------LKTLID-DDN-------PPVS 218

Query: 236 FVTGSHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEEN 295
           FV  S  G+ I+   LD T++ ++ +           +  K C  +N       T  +  
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN----FSVTGGKWI 274

Query: 296 VFAAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCS---EDGSVRIWE 350
           V  +    +Y+++LQ K ++  +   H   V+  A  P   +I+ +    D ++++W+
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQ-KLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 19/65 (29%), Positives = 33/65 (50%), Gaps = 9/65 (13%)

Query: 59  SAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASA--DRTVI 116
           S  +D +V +WN QT E + +L GHT  + +        +C     +I +A+   D+T+ 
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS-------TACHPTENIIASAALENDKTIK 328

Query: 117 VWDGD 121
           +W  D
Sbjct: 329 LWKSD 333



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 9/118 (7%)

Query: 53  DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
           D     SA DD  + +W+  +G+ L  L GH+  +      P       ++ LI++ S D
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-------QSNLIVSGSFD 150

Query: 113 RTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND-LC-VWNRKLDLLCKT 168
            +V +WD  T + ++ +      V  +   +   + +S   D LC +W+       KT
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 60/298 (20%), Positives = 126/298 (42%), Gaps = 32/298 (10%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           AS+  D ++ +W A  G+    ++GH   I+ +       +    + L+++AS D+T+ +
Sbjct: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDV-------AWSSDSNLLVSASDDKTLKI 113

Query: 118 WDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND--LCVWNRKLDLLCKTSHLSDTG 175
           WD  + + ++ +    + V C     + ++ +SG  D  + +W+ K     KT       
Sbjct: 114 WDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 173

Query: 176 ISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLS 235
           +SA V   ++  +        + R+     G        +K L+D  DN         +S
Sbjct: 174 VSA-VHFNRDGSLIVSSSYDGLCRIWDTASGQC------LKTLID-DDN-------PPVS 218

Query: 236 FVTGSHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEEN 295
           FV  S  G+ I+   LD T++ ++ +           +  K C  +N       T  +  
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN----FSVTGGKWI 274

Query: 296 VFAAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCS---EDGSVRIWE 350
           V  +    +Y+++LQ K ++  +   H   V+  A  P   +I+ +    D ++++W+
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQ-KLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 19/65 (29%), Positives = 33/65 (50%), Gaps = 9/65 (13%)

Query: 59  SAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASA--DRTVI 116
           S  +D +V +WN QT E + +L GHT  + +        +C     +I +A+   D+T+ 
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS-------TACHPTENIIASAALENDKTIK 328

Query: 117 VWDGD 121
           +W  D
Sbjct: 329 LWKSD 333



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 9/118 (7%)

Query: 53  DDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASAD 112
           D     SA DD  + +W+  +G+ L  L GH+  +      P       ++ LI++ S D
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-------QSNLIVSGSFD 150

Query: 113 RTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND-LC-VWNRKLDLLCKT 168
            +V +WD  T + ++ +      V  +   +   + +S   D LC +W+       KT
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 11/95 (11%)

Query: 40  KAHHDIVRFLVQLDDYRF-ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLES 98
           + H   VR L    D ++ ASA DD  V +W+   G+ + E  GHT  +  +   P+   
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN--- 200

Query: 99  CEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQ 133
                 L+ + S+DRT+  WD     + Q +SC +
Sbjct: 201 ----EYLLASGSSDRTIRFWD---LEKFQVVSCIE 228



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 23/97 (23%), Positives = 44/97 (45%), Gaps = 7/97 (7%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           A+ GDD  V +W+      ++ L GHT  + ++     L + EE   LI+  S   ++ V
Sbjct: 37  ATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV----RLNTPEE---LIVAGSQSGSIRV 89

Query: 118 WDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGND 154
           WD +  + ++ +   ++ +  L      +   SG  D
Sbjct: 90  WDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 61/278 (21%), Positives = 112/278 (40%), Gaps = 58/278 (20%)

Query: 15  LAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFL-VQLDDYRFASAGDDGIVVVWNAQT 73
           +A+K+P  T+ + Q   P+    V+  H   VR + V+  +  F +   D  + +W+  +
Sbjct: 178 MAKKAP--TMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLAS 235

Query: 74  GEKLLELNGHTQKITAIIT---FPSLESCEEKNQ-------------------------- 104
           G+  L L GH   +  +I     P L SC E  Q                          
Sbjct: 236 GKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLD 295

Query: 105 ------LILTASADRTVIVWDGDTTRQVQRISCFQ---STVKCLTVLQRLDVWLSGGNDL 155
                 +++T S D T  +WD  T   V  +S      +TV+C     ++   ++G +D 
Sbjct: 296 LHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQI---ITGSHDT 352

Query: 156 CVWNRKLDLLCKTSHLSDT----GISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWD 211
            +  R  DL+   + ++ T     + A+V  P++   A+   + I  +     +GS    
Sbjct: 353 TI--RLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNI--KQWKFPDGSF--- 405

Query: 212 ILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWD 249
              ++ L  H   I +L   +D   V+G+  G + +WD
Sbjct: 406 ---IQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 25/93 (26%), Positives = 42/93 (45%), Gaps = 15/93 (16%)

Query: 39  LKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLES 98
           L  H+ I+  L    D    S  D+G + +W+ +TG          Q++ A +   SL+S
Sbjct: 409 LSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNF-------QRVHAAVQPGSLDS 461

Query: 99  --------CEEKNQLILTASADRTVIVWDGDTT 123
                    ++    +LTA AD+T+ V+  D T
Sbjct: 462 ESGIFACAFDQSESRLLTAEADKTIKVYREDDT 494


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 24/62 (38%), Positives = 34/62 (54%), Gaps = 7/62 (11%)

Query: 58  ASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIV 117
           ASAG+D  + +W+  +G    EL GHT  IT++   P        + LI +AS D +V V
Sbjct: 484 ASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD-------SGLIASASMDNSVRV 536

Query: 118 WD 119
           WD
Sbjct: 537 WD 538



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 56/276 (20%), Positives = 103/276 (37%), Gaps = 34/276 (12%)

Query: 26  EEQTQNPYTELLVLKAHHDIV---RFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNG 82
           +++  N  TE+ +L+ H   V   RFL   D     S  +D  +  W+  +    +   G
Sbjct: 325 DDEDDNAGTEMKILRGHCGPVYSTRFLA--DSSGLLSCSEDMSIRYWDLGSFTNTVLYQG 382

Query: 83  HTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVL 142
           H   +  +   P        +    + S DRT  +W  D T  ++  +   + V C+   
Sbjct: 383 HAYPVWDLDISPY-------SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435

Query: 143 QRLDVWLSGGNDLCV--WNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRL 200
              +   +G  D  V  W+ +     +        + +L   P    +A+ G++  + +L
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRL-KL 494

Query: 201 VAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELI-IWDALDWTMQAYE 259
                G+L       K L  H DNI SL    D   +  + +   + +WD          
Sbjct: 495 WDLASGTL------YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI--------- 539

Query: 260 RNFWDPSPQLDTQQE---IKLCQKSNDISIHHFTCD 292
           RN +  +P   +  E   +   Q SN +S+    C+
Sbjct: 540 RNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACN 575


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,665,041
Number of Sequences: 37866
Number of extensions: 759567
Number of successful extensions: 2938
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 1928
Number of HSP's gapped (non-prelim): 943
length of query: 459
length of database: 18,247,518
effective HSP length: 106
effective length of query: 353
effective length of database: 14,233,722
effective search space: 5024503866
effective search space used: 5024503866
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.