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Search of human proteins with 12656655
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
(772 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 1538 0.0
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 776 0.0
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 776 0.0
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 722 0.0
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 716 0.0
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 713 0.0
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 707 0.0
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 691 0.0
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 685 0.0
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 685 0.0
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 679 0.0
gi|16753221 cadherin 22 precursor [Homo sapiens] 646 0.0
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 555 e-158
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 538 e-152
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 480 e-135
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 318 1e-86
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 310 4e-84
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 307 2e-83
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 306 4e-83
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 301 2e-81
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 233 7e-61
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 207 4e-53
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 190 4e-48
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 190 4e-48
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 188 2e-47
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 186 5e-47
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 186 5e-47
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 186 7e-47
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 186 7e-47
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 176 6e-44
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 1538 bits (3983), Expect = 0.0
Identities = 772/772 (100%), Positives = 772/772 (100%)
Query: 1 MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTS 60
MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTS
Sbjct: 1 MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTS 60
Query: 61 HHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVI 120
HHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVI
Sbjct: 61 HHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVI 120
Query: 121 DIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSS 180
DIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSS
Sbjct: 121 DIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSS 180
Query: 181 GNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTT 240
GNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTT
Sbjct: 181 GNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTT 240
Query: 241 SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDS 300
SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDS
Sbjct: 241 SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDS 300
Query: 301 QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ 360
QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ
Sbjct: 301 QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ 360
Query: 361 VEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNG 420
VEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNG
Sbjct: 361 VEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNG 420
Query: 421 TITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCE 480
TITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCE
Sbjct: 421 TITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCE 480
Query: 481 NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL 540
NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL
Sbjct: 481 NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL 540
Query: 541 QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA 600
QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA
Sbjct: 541 QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA 600
Query: 601 ILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELR 660
ILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELR
Sbjct: 601 ILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELR 660
Query: 661 SSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQT 720
SSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQT
Sbjct: 661 SSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQT 720
Query: 721 YAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 772
YAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN
Sbjct: 721 YAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 772
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 776 bits (2005), Expect = 0.0
Identities = 404/753 (53%), Positives = 530/753 (70%), Gaps = 10/753 (1%)
Query: 26 SQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGA 84
S++K Q RS R KR WVWNQFFV EE M + ++G+L SD+D G+ S +Y L G
Sbjct: 32 SRSKPYFQSGRS--RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGE 89
Query: 85 GAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDN 144
GA S FIIDE TGDI+A ++LDREE++ Y LRAQ +D T + VEPESEFVIK+ DINDN
Sbjct: 90 GASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDN 149
Query: 145 EPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTG 204
EPKFLD PY A VPEMSP GT V+QVTA+DADDP+ GN+AR++YS+LQGQPYFSVEP TG
Sbjct: 150 EPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTG 209
Query: 205 VIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRL 263
VI+ + MDRE +D+Y ++IQAKDM+GQ G LSGTTSV + L+DVNDN P F Y+
Sbjct: 210 VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQY 269
Query: 264 TVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKV 322
V ES P + + I A D DIG NAEM+Y I + D F I + ETQEGI+ ++K++
Sbjct: 270 NVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKEL 329
Query: 323 DFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEE 382
DFE + Y +R + N + + + TT +KI VEDVDEPP+F P Y EV E
Sbjct: 330 DFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEA 389
Query: 383 TPQGSFVGVVSATDPDNRKSPIRYSITRS----KVFNINDN-GTITTSNSLDREISAWYN 437
T G+ +G V+A DPD+ SP+RYSI R+ + FNI+ N G ITT+ SLDRE +A +N
Sbjct: 390 TQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHN 449
Query: 438 LSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRD 497
+++ A E N Q+ + + +L+IND+APEF+ YET VCENA GQVIQ ISAVD+D
Sbjct: 450 ITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKD 509
Query: 498 ESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGI 557
E H FYF+L+ + TNN +F++ DN+DNTA ILT R GF QE+ V+Y+ I I D+G
Sbjct: 510 EPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGS 569
Query: 558 PSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLG 617
PSL+STNTLTI VCDC G QTC + VL G T +IAIL C++ + I L +
Sbjct: 570 PSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVT 629
Query: 618 LKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAE 677
+++R+K+ L ++ D RENI +YDDEGGGEEDTEAFD+A LR+ ++R+ KTR+ + E
Sbjct: 630 MRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPE 689
Query: 678 IRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLE 737
I+ L R + + PD+ IFR+FI E+L+EA+ DP APP+DSLQTYAFEG GS+A SLSSL+
Sbjct: 690 IQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLD 749
Query: 738 SAVSDQDESYDYLNELGPRFKRLACMFGSAVQS 770
S S+ D++YDYL++ GPRFKRLA M+G+ +S
Sbjct: 750 SISSNSDQNYDYLSDWGPRFKRLADMYGTGQES 782
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 776 bits (2005), Expect = 0.0
Identities = 404/753 (53%), Positives = 530/753 (70%), Gaps = 10/753 (1%)
Query: 26 SQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGA 84
S++K Q RS R KR WVWNQFFV EE M + ++G+L SD+D G+ S +Y L G
Sbjct: 32 SRSKPYFQSGRS--RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGE 89
Query: 85 GAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDN 144
GA S FIIDE TGDI+A ++LDREE++ Y LRAQ +D T + VEPESEFVIK+ DINDN
Sbjct: 90 GASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDN 149
Query: 145 EPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTG 204
EPKFLD PY A VPEMSP GT V+QVTA+DADDP+ GN+AR++YS+LQGQPYFSVEP TG
Sbjct: 150 EPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTG 209
Query: 205 VIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRL 263
VI+ + MDRE +D+Y ++IQAKDM+GQ G LSGTTSV + L+DVNDN P F Y+
Sbjct: 210 VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQY 269
Query: 264 TVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKV 322
V ES P + + I A D DIG NAEM+Y I + D F I + ETQEGI+ ++K++
Sbjct: 270 NVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKEL 329
Query: 323 DFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEE 382
DFE + Y +R + N + + + TT +KI VEDVDEPP+F P Y EV E
Sbjct: 330 DFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEA 389
Query: 383 TPQGSFVGVVSATDPDNRKSPIRYSITRS----KVFNINDN-GTITTSNSLDREISAWYN 437
T G+ +G V+A DPD+ SP+RYSI R+ + FNI+ N G ITT+ SLDRE +A +N
Sbjct: 390 TQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHN 449
Query: 438 LSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRD 497
+++ A E N Q+ + + +L+IND+APEF+ YET VCENA GQVIQ ISAVD+D
Sbjct: 450 ITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKD 509
Query: 498 ESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGI 557
E H FYF+L+ + TNN +F++ DN+DNTA ILT R GF QE+ V+Y+ I I D+G
Sbjct: 510 EPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGS 569
Query: 558 PSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLG 617
PSL+STNTLTI VCDC G QTC + VL G T +IAIL C++ + I L +
Sbjct: 570 PSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVT 629
Query: 618 LKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAE 677
+++R+K+ L ++ D RENI +YDDEGGGEEDTEAFD+A LR+ ++R+ KTR+ + E
Sbjct: 630 MRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPE 689
Query: 678 IRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLE 737
I+ L R + + PD+ IFR+FI E+L+EA+ DP APP+DSLQTYAFEG GS+A SLSSL+
Sbjct: 690 IQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLD 749
Query: 738 SAVSDQDESYDYLNELGPRFKRLACMFGSAVQS 770
S S+ D++YDYL++ GPRFKRLA M+G+ +S
Sbjct: 750 SISSNSDQNYDYLSDWGPRFKRLADMYGTGQES 782
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 722 bits (1864), Expect = 0.0
Identities = 379/743 (51%), Positives = 508/743 (68%), Gaps = 11/743 (1%)
Query: 36 RSHLRVKRGWVWNQFFVPEEMNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDE 94
+SH R KR WVWNQFFV EE T ++G+L SD+D G+ S +Y L G GAG F ID+
Sbjct: 52 QSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDD 111
Query: 95 RTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYE 154
TGDI+AIQ+LDREER+ Y LRAQ +D TGR +EPESEF+IK+ DINDNEPKFLD PY
Sbjct: 112 TTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYV 171
Query: 155 AIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMD 213
A VPEMSP GT VIQVTA+DADDP+ GN+AR++YS+LQGQPYFSV+ TGVIR + MD
Sbjct: 172 ATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMNMD 231
Query: 214 RELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGT 273
RE ++ Y VIIQAKDM GQ G L+GTT+V I LSDVNDN P F + Y+++V ESAP +
Sbjct: 232 REAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISS 291
Query: 274 SIGTIMAYDNDIGENAEMDYSIEEDD-SQTFDIITNHETQEGIVILKKKVDFEHQNHYGI 332
++G + A D D G NAEM Y+I + D + FDI T+ Q GI+ +KK + FE + Y +
Sbjct: 292 TVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTL 351
Query: 333 RAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVV 392
+ + N H+ + + TT + I VEDVDEPP+F +Y EV E+ G+ + ++
Sbjct: 352 KVEGANPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQII 411
Query: 393 SATDPDNRKSPIRYSITRS----KVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYN 447
SA DPD + IRYSI RS + F ++ G + T+ LDRE +W+N+++ A E N
Sbjct: 412 SAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNN 471
Query: 448 IEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYF 507
Q+ S+P+ ++VL++ND+APEF ++YE +VCENA +GQ+IQT+SAVD+D+ HFY+
Sbjct: 472 PSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYY 531
Query: 508 NLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLT 567
+L+ E NN +FTI DNQDNTA ILT R+GF QE+ VF++ ILIAD+G P L+ST TLT
Sbjct: 532 SLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLT 591
Query: 568 IHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILF 627
I VC C D G +C + +L + +IAIL CI ++ + L L +++ RKQ
Sbjct: 592 IQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAILACIFVLLVLVLLILSMRRHRKQPYI 651
Query: 628 PEKSEDFRENIFQYDDEGGGEEDTEAFDIAEL---RSSTIMRERKTRKTTSAEIRSLYRQ 684
+ E+ ENI +YDDEGGGEEDTEAFDIA + R + KTR+ EI SL R
Sbjct: 652 IDDEENIHENIVRYDDEGGGEEDTEAFDIAAMWNPREAQAGAAPKTRQDMLPEIESLSRY 711
Query: 685 SLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQD 744
Q ++ ++L KL EA+ D APPFDSLQTY FEG GS+AGSLSSL+SA SD +
Sbjct: 712 VPQTCAVNSTVHSYVLAKLYEADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSE 771
Query: 745 ESYDYLNELGPRFKRLACMFGSA 767
+S+D+L + GPRF++LA ++G++
Sbjct: 772 QSFDFLTDWGPRFRKLAELYGAS 794
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 716 bits (1848), Expect = 0.0
Identities = 366/734 (49%), Positives = 509/734 (69%), Gaps = 9/734 (1%)
Query: 40 RVKRGWVWNQFFVPEEMN-TTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
R KRGW+WNQFF+ EE T + ++G+L +D D G+ + +Y L G GAGS F+IDE TGD
Sbjct: 50 RTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGD 109
Query: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
I+A +KLDREE+SLYILRA+ ID TGR VEPESEF+IK+ DINDNEPKF + Y A VP
Sbjct: 110 IHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVP 169
Query: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
EMS GT VIQVTA+DADD + GN+A+++YS+LQGQPYFSV+P +G+I+ + M RE +
Sbjct: 170 EMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENR 229
Query: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
++Y V+IQAKDM GQ G LSGTT+V I L+DVN+N P F +S Y+ ES P GT +G
Sbjct: 230 EQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGR 289
Query: 278 IMAYDNDIGENAEMDYSIEEDD-SQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKV 336
I A D D+GENAEM+YSI E D + FD+IT+ +TQEGI+ +K+ +DFE+Q Y +R
Sbjct: 290 IKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDA 349
Query: 337 KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATD 396
N H + + T +KI VED+DEPP+F Y+ EV E+ +GS +G V+A D
Sbjct: 350 SNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYD 409
Query: 397 PDNRKSPIRYSITR----SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
PD R + I+YS+ R ++F I+ +NG+I T +LDRE S W+N+++TATE N +Q
Sbjct: 410 PDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQS 469
Query: 452 SSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSV 511
S IP+++++L+INDHAPEF+ YYET+VCENA GQ+IQT+S +D+D+ H F+F
Sbjct: 470 SHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVP 529
Query: 512 EDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
E T N +FTI+DN+DNTA I+T + G++ + + + ILI DN P +ST TLTI VC
Sbjct: 530 EFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVC 589
Query: 572 DCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKS 631
C + G+ Q+C + L+LS G T ++AIL+C++I+ + L LK++RK+
Sbjct: 590 ACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISK 649
Query: 632 EDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPD 691
+D R+NI Y+DEGGGEEDT+AFDI LR+ + K R+ E R+++ + +
Sbjct: 650 DDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWEN 709
Query: 692 SAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLN 751
+ + FI +L+E + DP APP+DSL TYA+EG S+A SLSSLES +D ++ YDYL+
Sbjct: 710 IDV-QDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLS 768
Query: 752 ELGPRFKRLACMFG 765
+ GPRFK+LA M+G
Sbjct: 769 DWGPRFKKLADMYG 782
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 713 bits (1840), Expect = 0.0
Identities = 366/734 (49%), Positives = 511/734 (69%), Gaps = 12/734 (1%)
Query: 40 RVKRGWVWNQFFVPEEMNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
R KRGW+WNQFF+ EE + + ++G+L SD D G+ S +Y L G GAG+ FIIDE+TGD
Sbjct: 51 RQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGD 110
Query: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
I+A +++DREE++ Y LRAQ I+ T R VEPESEFVIK+ DINDNEP F +E Y A VP
Sbjct: 111 IHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVP 170
Query: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
EMS GT V+QVTA+DADDPS GN+AR++YS+LQGQPYFSVEP TG+IR + M+RE +
Sbjct: 171 EMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENR 230
Query: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
++Y V+IQAKDM GQ G LSGTT+V I L+DVNDN P F ++ L V ES+P GT+IG+
Sbjct: 231 EQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGS 290
Query: 278 IMAYDNDIGENAEMDYS-IEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKV 336
+ A D D G+NAE++Y I+ D + FDI+T +TQEGI+ +KK +D+E + Y ++ +
Sbjct: 291 VKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEA 350
Query: 337 KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATD 396
+N HV + TT +KI +EDVDEPP+F Y+FEV E+ G+ +G V A D
Sbjct: 351 ENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARD 410
Query: 397 PDNRKSPIRYSITR----SKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
PD+ SPIR+S+ R ++FNI+ NG++ TS LDRE+S W+NL++ A E N ++
Sbjct: 411 PDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKET 470
Query: 452 SSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSV 511
+ + ++V++L++ND+AP+F+ +Y+T+VCENA GQ+IQTISAVD+D+ + F+F+L+
Sbjct: 471 TRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAA 530
Query: 512 EDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
N +FT+ DN+DNTA ILT + GFN E + + ++I+DN P +ST TLTI VC
Sbjct: 531 V---NPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVC 587
Query: 572 DCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKS 631
C G+ Q+C + L+L G T +IAIL+CI+I+ + L LK++RK+
Sbjct: 588 ACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSK 647
Query: 632 EDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPD 691
ED R+NI Y+DEGGGEEDT+AFDI LR+ + E+K R+ E + R++ PD
Sbjct: 648 EDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRT-PTAPD 706
Query: 692 SAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLN 751
+ R FI E+L+E + DP APP+DSL TYA+EG S+A SLSSLES ++ D++YDYL
Sbjct: 707 NTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLR 766
Query: 752 ELGPRFKRLACMFG 765
E GPRF +LA M+G
Sbjct: 767 EWGPRFNKLAEMYG 780
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 707 bits (1825), Expect = 0.0
Identities = 371/778 (47%), Positives = 520/778 (66%), Gaps = 17/778 (2%)
Query: 4 YLLLRFMLGIP---LLWPCLGATENSQTKKVKQPVRSHL-----RVKRGWVWNQFFVPEE 55
Y LL F +G P L P T KK + + R KR W+WNQFF+ EE
Sbjct: 6 YFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEE 65
Query: 56 MNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYI 114
+ + ++G+L SD D G+ S +Y L G GAG FII+E TGDI A ++LDREE+ +YI
Sbjct: 66 YTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYI 125
Query: 115 LRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASD 174
LRAQ I+ TGR VEPESEF+IK+ DINDNEP F E Y A VPEMS GT V+QVTA+D
Sbjct: 126 LRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATD 185
Query: 175 ADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISS-KMDRELQDEYWVIIQAKDMIGQP 233
ADDP+ GN+A+++YS+LQGQPYFSVE TG+I+ + MDRE +++Y V+IQAKDM GQ
Sbjct: 186 ADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQM 245
Query: 234 GALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDY 293
G LSGTT+V I L+DVNDN P F +S Y+ ES+P GT IG I A D D+GENAE++Y
Sbjct: 246 GGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEY 305
Query: 294 SIEEDDS-QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEA 352
SI + + FD+IT+ ETQEGI+ +KK +DFE + Y ++ + N +V + +
Sbjct: 306 SITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFK 365
Query: 353 STTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITR-- 410
+ ++I VEDVDEPP+F Y+ ++ E+ + +G V+A DPD ++P++YS+ R
Sbjct: 366 DSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHT 425
Query: 411 --SKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 467
++FNI+ NG+I TS LDRE W+N+++ ATE N +Q S +PLY++VL++ND+A
Sbjct: 426 DMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNA 485
Query: 468 PEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDN 527
PEF+++YET+VCE A + Q+IQT+ AVD+D+ H F F+L+ E + S+FTI DN+DN
Sbjct: 486 PEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDN 545
Query: 528 TAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQEL 587
TA ILT + G+N E + + ++I+DN P +ST T+T+ VC C G+ Q+C + L
Sbjct: 546 TAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEAL 605
Query: 588 VLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGG 647
+ G T ++AIL+CI+I+ + L L+++RK+ ED R+NI Y+DEGGG
Sbjct: 606 IHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGG 665
Query: 648 EEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEAN 707
EEDT+AFDI LR+ + + K R+ E L R++ D+ R FI ++L+E +
Sbjct: 666 EEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRT-PTARDNTDVRDFINQRLKEND 724
Query: 708 TDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
TDP APP+DSL TYA+EGTGS+A SLSSLES +D D+ YDYL++ GPRFK+LA M+G
Sbjct: 725 TDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 691 bits (1783), Expect = 0.0
Identities = 362/745 (48%), Positives = 494/745 (66%), Gaps = 10/745 (1%)
Query: 36 RSHL-RVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIID 93
RSH RVKRGWVWNQFFV EE + + ++G+L SDLD G + +Y L G GAG+ F ID
Sbjct: 46 RSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTID 105
Query: 94 ERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPY 153
E TGDI+AI+ LDREE+ Y LRAQ +DI T + +EPESEF+IKV DINDNEPKFLD PY
Sbjct: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
Query: 154 EAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKM 212
A VPEMSP G V+QV A+DADDP+ GN+AR++YS+LQGQPYFS++P TGVIR + M
Sbjct: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNM 225
Query: 213 DRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTG 272
DRE++++Y V+IQAKDM GQ G L+GTT V I L+DVNDN P F +S++ L V ES+P G
Sbjct: 226 DREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIG 285
Query: 273 TSIGTIMAYDNDIGENAEMDYSIEEDDS-QTFDIITNHETQEGIVILKKKVDFEHQNHYG 331
++IG I A D D G+NAE++Y+I D FDI+T+ +TQEG++ LKK +DFE + Y
Sbjct: 286 SAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYT 345
Query: 332 IRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGV 391
+ + N H+ + T +KI V DVDEPP+F P Y EV+E+TP G+ +G
Sbjct: 346 FKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGA 405
Query: 392 VSATDPDNRKSPIRYSIT----RSKVFNINDN-GTITTSNSLDREISAWYNLSITATEKY 446
V+A D D S +RY I F I+ N GTI T+ LDRE +A YN SI A++
Sbjct: 406 VTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVS 465
Query: 447 NIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFY 506
N S + + + VL++N+ PE S YET VCENA GQ+IQ +SA DRD S F
Sbjct: 466 NPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFS 525
Query: 507 FNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTL 566
F LS E +FT+ D ++NTA I T R G++ +++ ++++ ++I D+ P +STNT+
Sbjct: 526 FRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTM 585
Query: 567 TIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQIL 626
TI VC C G+ +C + + L +G T +IAIL+CI+I+ + L + L++++K+
Sbjct: 586 TIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDT 645
Query: 627 FPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSL 686
ED R+N+ YDDEGGGEEDT+AFDI LR+ ++ E K R+ + L RQ
Sbjct: 646 LMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRP 705
Query: 687 QVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDES 746
+ D+ R FI ++L+E + DP APP+DSL TYA+EG+GS+A SLSS++S ++ D+
Sbjct: 706 PM-EDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQD 764
Query: 747 YDYLNELGPRFKRLACMFGSAVQSN 771
YDYL + GPRFK LA MFG N
Sbjct: 765 YDYLTDWGPRFKVLADMFGEEESYN 789
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 685 bits (1768), Expect = 0.0
Identities = 359/739 (48%), Positives = 498/739 (67%), Gaps = 12/739 (1%)
Query: 40 RVKRGWVWNQFFVPEEMNTTSHH-IGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
R KRGWVWNQFFV EE +G+L SD+D+G+ + +Y L G GAG+ F+ID+++G+
Sbjct: 50 RSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGN 109
Query: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
I+A + LDREER+ Y L AQ +D T R +EP SEF++KV DINDN P+FL E Y A VP
Sbjct: 110 IHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVP 169
Query: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
E S GT VIQVTASDADDP+ GN+A+L+YS+L+GQPYFSVE TG+IR + MDRE +
Sbjct: 170 ERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAK 229
Query: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
+EY V+IQAKDM G G LSGTT V I L+DVNDN P F +S+Y+++VSE+A G +G
Sbjct: 230 EEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGR 289
Query: 278 IMAYDNDIGENAEMDYSIEEDDS-QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKV 336
+ A D DIGEN + Y+I + D ++F+I T++ETQEG++ LKK VDFE + Y ++ +
Sbjct: 290 VKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEA 349
Query: 337 KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATD 396
N H+ + + T +KI VED DEPP+FL P Y+ EV E G+ VG V A D
Sbjct: 350 ANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKD 409
Query: 397 PDNRKSPIRYSITR----SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
PD SPIRYSI R + F IN ++G I T+ LDRE +AW N+++ A E +N Q
Sbjct: 410 PDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQE 469
Query: 452 SSIPLYVQVLNINDHAPEFSQYYETYVCENAG----SGQVIQTISAVDRDESIEEHHFYF 507
+ +P+ ++VL++ND+AP+F+ YE ++CE+ S Q I TISA D+D++ F F
Sbjct: 470 AKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIF 529
Query: 508 NLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLT 567
+L E +N +FT+ DN+DNTA + R GF+ Q++ ++ + I+I+D GIP ++STNTLT
Sbjct: 530 SLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLT 589
Query: 568 IHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILF 627
I VC C +G+ +C + +L+ G T +IAIL CI+I+ + L + L++++K+ L
Sbjct: 590 IKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLI 649
Query: 628 PEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQ 687
+ ED RENI YDDEGGGEEDTEAFDIA L++ + RK E + + R L+
Sbjct: 650 VFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLR 709
Query: 688 VGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESY 747
P+S FI +++EA+ DP APP+DS+Q Y +EG GS+AGSLSSLESA +D D Y
Sbjct: 710 PAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDY 769
Query: 748 DYLNELGPRFKRLACMFGS 766
DYL GPRFK+LA ++GS
Sbjct: 770 DYLQNWGPRFKKLADLYGS 788
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 685 bits (1767), Expect = 0.0
Identities = 353/733 (48%), Positives = 491/733 (66%), Gaps = 8/733 (1%)
Query: 40 RVKRGWVWNQFFVPEEMNTTSHH-IGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
R KRGWVWNQ FV EE + +G+L +DLD G+ +Y L G GAG+ F I++ TGD
Sbjct: 58 RSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGD 117
Query: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
I+AI++LDREE++ Y L AQ +D T + +EP SEF+IKV DINDN P+FL+ PY A VP
Sbjct: 118 IHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVP 177
Query: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
EMS GT V VTA+DADDP GN+A+L+YS+L+GQPYFS+EP T +I+ + MDRE +
Sbjct: 178 EMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAK 237
Query: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
+EY V+IQAKDM G G LSGTT++ + L+DVNDN P F +SLY +V E GT+IG
Sbjct: 238 EEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGR 297
Query: 278 IMAYDNDIGENAEMDYSI-EEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKV 336
+ A D DIGENA+ Y I + D + F+I ++ + Q+GI+ L+K +DFE + Y ++ +
Sbjct: 298 VKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEA 357
Query: 337 KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATD 396
N H+ + T +KI VED DEPP+F P Y+ EV E S +G V+A D
Sbjct: 358 ANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARD 417
Query: 397 PDNRKSPIRYSITR----SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
PD SPIR+SI R + FNIN D+G IT + LDRE+S W+N++I ATE N QI
Sbjct: 418 PDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQI 477
Query: 452 SSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSV 511
S +P+ ++VL++ND+APEF+ YE ++CEN GQVIQT+SA+D+D+ H+F ++L
Sbjct: 478 SRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLP 537
Query: 512 EDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
E NN +FTI N+DN+ IL GFN Q++ V+ + I+I+D+G P L+ST+TLTI VC
Sbjct: 538 EMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVC 597
Query: 572 DCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKS 631
C + G Q+C + VL +G +IAIL CI+++ + L + L++ + + L +
Sbjct: 598 GCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDD 657
Query: 632 EDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPD 691
ED RENI +YDDEGGGEEDTEAFDIA L++ + RK +++ + RQ L P+
Sbjct: 658 EDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPN 717
Query: 692 SAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLN 751
+FI +L EA+ DP APP+DS+Q Y +EG GS+AGSLSSLES SD D+++DYL+
Sbjct: 718 GVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLS 777
Query: 752 ELGPRFKRLACMF 764
+ GPRFKRL ++
Sbjct: 778 DWGPRFKRLGELY 790
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 679 bits (1751), Expect = 0.0
Identities = 359/748 (47%), Positives = 493/748 (65%), Gaps = 9/748 (1%)
Query: 26 SQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGA 84
+QTK ++ H R KRGWVWNQFFV EE M ++G+L S+ D G+ S +Y L G
Sbjct: 36 NQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGE 95
Query: 85 GAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDN 144
GAG+ FIID+ TGDI++ + LDRE+++ Y+L AQ ID T + +EPESEF+IKV DINDN
Sbjct: 96 GAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDN 155
Query: 145 EPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTG 204
PKF D PY VPEMS GT V+QVTA+DADDP+ GN+AR++YS+LQGQPYFSV+P TG
Sbjct: 156 APKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTG 215
Query: 205 VIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRL 263
VIR + MDRE ++ Y V+IQAKDM GQ G LSG+T+V I L+DVNDN P F + Y+L
Sbjct: 216 VIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQL 275
Query: 264 TVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKV 322
V ESA G+++G I A D D G NA+M YSI D F I T+ ET+EGI+ LKK +
Sbjct: 276 YVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPL 335
Query: 323 DFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEE 382
++E + Y + + N H+ + T +KI V DVDEPPLF +P Y+ EV+E
Sbjct: 336 NYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYEN 395
Query: 383 TPQGSFVGVVSATDPDNRKSPIR----YSITRSKVFNINDN-GTITTSNSLDREISAWYN 437
G+ VG V A DPD+ S +R Y++ + FNI+ N GTI T+ LDRE + WYN
Sbjct: 396 AKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYN 455
Query: 438 LSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRD 497
+++TA+E N + +S + + ++VL++ND+ PE ++ Y+ VCEN+ GQVI TISA D+D
Sbjct: 456 ITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKD 515
Query: 498 ESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGI 557
+ F F L N +FT+ DN+DNTA ILT R F+ + V+Y+ I+I+D GI
Sbjct: 516 DFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGI 575
Query: 558 PSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLG 617
PSL+S++TLTI VC C G +TC + + S G T +IAIL+C++I+ + L +
Sbjct: 576 PSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFIT 635
Query: 618 LKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAE 677
L++ +K+ L + ED REN+ YDDEGGGEEDTEAFDI LR+ + E K R+ E
Sbjct: 636 LRRSKKEPLIISE-EDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPE 694
Query: 678 IRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLE 737
++ R +S ++FI ++L EA+ DP PP+DSLQTYA+EG S AGS+SSL+
Sbjct: 695 VKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLD 754
Query: 738 SAVSDQDESYDYLNELGPRFKRLACMFG 765
SA + D+ Y YL + GP FK+LA ++G
Sbjct: 755 SATTQSDQDYHYLGDWGPEFKKLAELYG 782
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 646 bits (1667), Expect = 0.0
Identities = 336/758 (44%), Positives = 483/758 (63%), Gaps = 33/758 (4%)
Query: 40 RVKRGWVWNQFFVPEEMNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
RVKRGWVWNQFFV EE T ++G++ SD D G+ + +Y + G GAG+ F+IDE TGD
Sbjct: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGD 118
Query: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
I+A+++LDRE+++ Y LRAQ D AT R +EPESEF+IKV DIND+EP+FL PY V
Sbjct: 119 IHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVA 178
Query: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
E+SP GT V+QV ASDADDP+ G++ARL+YS+L G+ +F+V+P TGVIR + +DRE Q
Sbjct: 179 ELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQ 238
Query: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
+ Y V+IQA DM GQ G LSG+T+V I ++DVNDN P F + +Y+ ++ ESAP GT++G
Sbjct: 239 ERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR 298
Query: 278 IMAYDNDIGENAEMDYSIEEDDSQ---TFDIITNHETQEGIVILKKKVDFEHQNHYGIRA 334
+ A D+D+GEN +M Y ++++ S F + T+ +TQE I++++K++DFE Q + +
Sbjct: 299 VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVIL 358
Query: 335 KVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSA 394
+ N V + T +++ V DVDEPP F P + EV E+ GS VGVV+A
Sbjct: 359 EALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTA 418
Query: 395 TDPDNRKSPIRYSITRS----KVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 449
DPD P+RY+I R ++F+I+ D G I T LDRE + W+N+++ A E N
Sbjct: 419 RDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHA 478
Query: 450 QISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNL 509
Q+S L +++L++ND+ PE + YE VCE+A GQ+IQTIS VDRDE H FYF L
Sbjct: 479 QLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRL 538
Query: 510 SVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIH 569
E +N F+++D QDNTA + T GFN QE+ VF++ IL+ D+G P+L+ST TLTI
Sbjct: 539 VPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIR 598
Query: 570 VCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPE 629
+C C SG+ Q+C V++ +IA+L+C++I+ + L L L++ K L +
Sbjct: 599 ICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSD 658
Query: 630 KSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERK-------------------- 669
+ ED R+N+ +Y+DEGGGE+DTEA+D++ LRS E K
Sbjct: 659 EDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGA 718
Query: 670 ---TRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGT 726
+ +E SL + PD ++FR FI K+ A+ D PP+D+ QTYAFEG
Sbjct: 719 GSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGA 778
Query: 727 GSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMF 764
S A SLSSL S S ++ + YL+ GPRF+ LA ++
Sbjct: 779 DSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 555 bits (1431), Expect = e-158
Identities = 320/775 (41%), Positives = 462/775 (59%), Gaps = 17/775 (2%)
Query: 6 LLRFMLGIPLLWPCLG---ATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEM-NTTSH 61
L+R +L W C+G A + + P + LR +R WVWNQFFV EE
Sbjct: 4 LVRLLLAWLGGWGCMGRLAAPARAWAGSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPV 63
Query: 62 HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 121
IG+L SD+D G +Y L G GAG+ F+IDE TG+I+ + LDREE++ Y+L AQ +D
Sbjct: 64 LIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVD 123
Query: 122 IATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSG 181
A+ R +EP SEF+IKV DINDN P F PY A VPEMS GT VIQVTA DADDPS G
Sbjct: 124 RASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYG 183
Query: 182 NNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTT 240
N+A+L+Y++L G P+FSV+P TGV+R + MDRE Q+E+ V+IQAKDM G G LSG+T
Sbjct: 184 NSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGST 243
Query: 241 SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDD 299
+V + LSDVNDN P F +SLY+ +V E+A GT +G + A D D+G+NA M YSI + +
Sbjct: 244 TVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEG 303
Query: 300 SQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKI 359
S+ F I T+ + ++G++ ++K +DFE Q Y R + N + ++ +++
Sbjct: 304 SEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRV 363
Query: 360 QVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSI----TRSKVFN 415
V+D EPP F Y V E G+ VG +SA D D+ SPIRYSI + F+
Sbjct: 364 AVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFS 423
Query: 416 IN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYY 474
I + GTI T+ LDRE AW+NL++ ATE + Q S + + +Q L+ ND+AP+ ++ Y
Sbjct: 424 IQPEEGTIHTAAPLDREARAWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPY 483
Query: 475 ETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTN 534
+T+VC++A GQ+IQ I A+DRDE H F + +++FT+ DN+D +A +L
Sbjct: 484 DTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGP--DANFTVQDNRDGSASLLLP 541
Query: 535 RTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFK 594
+ P + + I + D G P+L+ST T+T+ VC C GS +C + + + G
Sbjct: 542 SRPAPPRHAP-YLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLS 600
Query: 595 TEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAF 654
T ++AI+ C+ + + L + L++++++ L + ED RENI YDDEGGGEEDTEAF
Sbjct: 601 TGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAF 660
Query: 655 DIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDS-AIFRKFILEKLEEANTDPCAP 713
DI L++ ++ R S Q P A + + +L EA+ DP P
Sbjct: 661 DITALQNPDGAAPPAPGPPARRDVLPRARVSRQPRPPGPADVAQLLALRLREADEDPGVP 720
Query: 714 PFDSLQTYAFEGTGSLAGSLSSLESA--VSDQDESYDYLNELGPRFKRLACMFGS 766
P+DS+Q Y +EG GS GSLSSL S + L++ GP F+ LA ++G+
Sbjct: 721 PYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGA 775
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 538 bits (1385), Expect = e-152
Identities = 320/813 (39%), Positives = 463/813 (56%), Gaps = 55/813 (6%)
Query: 6 LLRFMLGIPLLWPCLG---ATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEM-NTTSH 61
L+R +L W C+G A + + P + LR +R WVWNQFFV EE
Sbjct: 4 LVRLLLAWLGGWGCMGRLAAPARAWAGSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPV 63
Query: 62 HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 121
IG+L SD+D G +Y L G GAG+ F+IDE TG+I+ + LDREE++ Y+L AQ +D
Sbjct: 64 LIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVD 123
Query: 122 IATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSG 181
A+ R +EP SEF+IKV DINDN P F PY A VPEMS GT VIQVTA DADDPS G
Sbjct: 124 RASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYG 183
Query: 182 NNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTT 240
N+A+L+Y++L G P+FSV+P TGV+R + MDRE Q+E+ V+IQAKDM G G LSG+T
Sbjct: 184 NSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGST 243
Query: 241 SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDD 299
+V + LSDVNDN P F +SLY+ +V E+A GT +G + A D D+G+NA M YSI + +
Sbjct: 244 TVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEG 303
Query: 300 SQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKI 359
S+ F I T+ + ++G++ ++K +DFE Q Y R + N + ++ +++
Sbjct: 304 SEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRV 363
Query: 360 QVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSI----TRSKVFN 415
V+D EPP F Y V E G+ VG +SA D D+ SPIRYSI + F+
Sbjct: 364 AVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFS 423
Query: 416 IN-DNGTITTSNSLDREISAWYNLSITATE------------------------------ 444
I + GTI T+ LDRE AW+NL++ ATE
Sbjct: 424 IQPEEGTIHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSP 483
Query: 445 --------KYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDR 496
+ + Q S + + +Q L+ ND+AP+ ++ Y+T+VC++A GQ+IQ I A+DR
Sbjct: 484 VGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDR 543
Query: 497 DESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNG 556
DE H F + +++FT+ DN+D +A +L + P + + I + D G
Sbjct: 544 DEVGNSSHVSFQGPLGP--DANFTVQDNRDGSASLLLPSRPAPPRHAP-YLVPIELWDWG 600
Query: 557 IPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTL 616
P+L+ST T+T+ VC C GS +C + + + G T ++AI+ C+ + + L +
Sbjct: 601 QPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFV 660
Query: 617 GLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSA 676
L++++++ L + ED RENI YDDEGGGEEDTEAFDI L++
Sbjct: 661 ALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARR 720
Query: 677 EIRSLYRQSLQVGPDS-AIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSS 735
++ R S Q P A + + +L EA+ DP PP+DS+Q Y +EG GS GSLSS
Sbjct: 721 DVLPRARVSRQPRPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSS 780
Query: 736 LESA--VSDQDESYDYLNELGPRFKRLACMFGS 766
L S + L++ GP F+ LA ++G+
Sbjct: 781 LGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGA 813
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 480 bits (1235), Expect = e-135
Identities = 288/775 (37%), Positives = 430/775 (55%), Gaps = 32/775 (4%)
Query: 11 LGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTT-SHHIGQLRSD 69
LG+ + A N + + +H R KR W+WNQ + EE NT+ HH+G+++S
Sbjct: 15 LGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSS 74
Query: 70 LDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVE 129
+ N +Y L G G F +D TGD++AI++LDRE S Y L A ++D TG +E
Sbjct: 75 VSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLE 132
Query: 130 PESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYS 189
S F IKV D+NDN P F + A VPE S GT VI VTA DADDP+ G++A ++Y
Sbjct: 133 TPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQ 192
Query: 190 LLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDV 249
+L+G+ YF+++ + +I I+ +DRE Q Y ++++A+D G G SGT +VL+ L D+
Sbjct: 193 ILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGD-SGTATVLVTLQDI 251
Query: 250 NDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITN 308
NDN P F ++ Y V E GTS+G++ D D +N YSI D Q F I TN
Sbjct: 252 NDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETN 311
Query: 309 HETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPP 368
EGI+ K +D+E+ Y + + + + M + + I + DVDEPP
Sbjct: 312 PAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS-PPAGNRAQVIINITDVDEPP 370
Query: 369 LFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRS----KVFNINDNGTITT 424
+F P+Y F++ +E + +G V A DPD + I YSI R+ + F + G I
Sbjct: 371 IFQQPFYHFQL-KENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYN 429
Query: 425 SNSLDREISAWYNLSITATEKYN----IEQISSIPLYVQVLNINDHAPEFSQYYETYVCE 480
LDRE+ WYNL++ A E + + S + ++++VL+ ND+APEF++ Y+ VCE
Sbjct: 430 EKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCE 489
Query: 481 NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL 540
NA GQ++ ISA+D+D + F F L+ E ++FT+ DN DNTA I F+
Sbjct: 490 NAVHGQLVLQISAIDKDITPRNVKFKFILNTE----NNFTLTDNHDNTANITVKYGQFDR 545
Query: 541 QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA 600
+ V ++ ++I+DNG+PS T T+TLT+ VC C + G C +++ +G + ++A
Sbjct: 546 EHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVA 603
Query: 601 ILICIMIIFGFIFLTLGLKQRRKQILFPEKS-EDFRENIFQYDDEGGGEEDTEAFDIAEL 659
IL+CI+ I L ++ RKQ KS + E + YD+EGGGE DT ++D++ L
Sbjct: 604 ILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVL 663
Query: 660 RSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSA--------IFRKFILEKLEEANTDPC 711
S + R A SLY Q +Q P A I K +EA+ D
Sbjct: 664 NSVRRGGAKPPRPALDAR-PSLYAQ-VQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGD 721
Query: 712 APPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGS 766
PP+D+L Y +EG+ S+A SLSSL + SD D YD+LN+ GPRFK LA ++GS
Sbjct: 722 GPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGS 776
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 318 bits (815), Expect = 1e-86
Identities = 252/763 (33%), Positives = 379/763 (49%), Gaps = 54/763 (7%)
Query: 40 RVKRGWVWNQFFVPEEMNTT-SHHIGQLRSDLDNGNNSFQYKLLGAGAGS----TFIIDE 94
R KR WV VPE + ++RSD DN + +Y + G GA F ID
Sbjct: 166 RRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDN-DIPIRYSITGVGADQPPMEVFSIDS 224
Query: 95 RTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYE 154
+G +Y + +DREE + Y LRA +D+ G VE + I V D+NDN P+F+++ Y
Sbjct: 225 MSGRMYVTRPMDREEHASYHLRAHAVDM-NGNKVENPIDLYIYVIDMNDNRPEFINQVYN 283
Query: 155 AIVPEMSPEGTLVIQVTASDADDPSSGNNA---RLLYSLLQ--GQPYFSVEPTTG-VIRI 208
V E S GT V+ VTA+DADD ++ N R++ Q Q F++ TG ++ +
Sbjct: 284 GSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTV 343
Query: 209 SSKMDRELQDEYWVIIQAKDMIGQPG-ALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSE 267
++ +DRE +Y VI+QA DM G LS T + +I ++DVNDN P F S + V E
Sbjct: 344 AAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPE 403
Query: 268 S-APTGTSIGTIMAYDNDIGENAEMDYS-IEEDDSQTFDIITNHETQEGIVILKKKVDFE 325
+ T + T+M D N Y I D S F + T+ T EG+V + K VD+E
Sbjct: 404 NRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYE 463
Query: 326 HQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQ 385
+ + V N P + ST + I + D++E P F + + + E P
Sbjct: 464 LNRAFMLTVMVSN-QAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPP 522
Query: 386 GSFVGVVSATDPDN-RKSPIRYSITRSKV--FNIN-DNGTITTSNSLDREI----SAWYN 437
G+ + SA DPD + +RYS +IN NG ITT+ LDRE + Y
Sbjct: 523 GTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYE 582
Query: 438 LSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRD 497
+ A + + L + +++IND+APE E +CE + T + D D
Sbjct: 583 ATFLAADNGIPPASGTGTLQIYLIDINDNAPELLP-KEAQICEKPNLNAINITAADADVD 641
Query: 498 ESIEEHHFYFNLSVEDTNNSSFTIID-NQDNTAVILTNRTGFNLQEEPVFYISILIADNG 556
+I + F V ++TI N D + L E ++ + I++ D+G
Sbjct: 642 PNIGPYVFELPF-VPAAVRKNWTITRLNGDYAQLSLR----ILYLEAGMYDVPIIVTDSG 696
Query: 557 IPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFL-T 615
P L++T+ + + VC C D+G C V + G T I+AILICI+I+ + L
Sbjct: 697 NPPLSNTSIIKVKVCPCDDNGD---CTTIGAVAAAGLGTGAIVAILICILILLTMVLLFV 753
Query: 616 LGLKQRRKQ----ILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMR----- 666
+ +K+R K+ L + +D R+NI +YD+EGGGEED + +D+++L+ M
Sbjct: 754 MWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPEAMGHVPSK 812
Query: 667 ----ERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYA 722
R + AE + R + P FI E L A+ DP APP+DSL +
Sbjct: 813 APGVRRVDERPVGAEPQYPIRPMV---PHPGDIGDFINEGLRAADNDPTAPPYDSLLVFD 869
Query: 723 FEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
+EG+GS AGS+SSL S+ S D+ YDYLN+ GPRFK+LA M+G
Sbjct: 870 YEGSGSTAGSVSSLNSS-SSGDQDYDYLNDWGPRFKKLADMYG 911
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 310 bits (793), Expect = 4e-84
Identities = 249/754 (33%), Positives = 380/754 (50%), Gaps = 55/754 (7%)
Query: 40 RVKRGWVWNQFFVPE-EMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGS----TFIIDE 94
R KR WV PE E ++ Q++S+ D F Y + G GA + FII+
Sbjct: 151 RQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVF-YSITGQGADTPPVGVFIIER 209
Query: 95 RTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYE 154
TG + + LDRE + Y L + + + G AVE E +I V+D NDN+P+F E ++
Sbjct: 210 ETGWLKVTEPLDRERIATYTLFSHAVS-SNGNAVEDPMEILITVTDQNDNKPEFTQEVFK 268
Query: 155 AIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP------YFSVEPTTGVIRI 208
V E + GT V++VTA+DADD + NA + Y++L P F++ TGVI +
Sbjct: 269 GSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISV 328
Query: 209 -SSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSE 267
++ +DRE Y +++QA D+ G+ LS T + +I ++D NDN PIF + Y+ V E
Sbjct: 329 VTTGLDRESFPTYTLVVQAADLQGE--GLSTTATAVITVTDTNDNPPIFNPTTYKGQVPE 386
Query: 268 SAPTGTSIGTIMAYDNDIGENA--EMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFE 325
+ I T+ D D E Y+I DD F + TN +GI+ K +DFE
Sbjct: 387 NE-ANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFE 445
Query: 326 HQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQ 385
+ Y + V N VP ++ ST + + V DV+E P+F+ P EV E+
Sbjct: 446 AKQQYILHVAVTNV-VPFEVS---LTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGV 501
Query: 386 GSFVGVVSATDPDN-RKSPIRYSITRSKV--FNIN-DNGTITTSNSLDREI-----SAWY 436
G + +A +PD + I Y I R IN D G I+T LDRE ++ Y
Sbjct: 502 GQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTY 561
Query: 437 NLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDR 496
I AT+ + + L + + ++ND+AP + + CE QVI I
Sbjct: 562 TALIIATDNGSPVATGTGTLLLILSDVNDNAP-IPEPRTIFFCERNPKPQVINII----- 615
Query: 497 DESIEEHHFYFNLSVEDTNNSSFTIIDNQDNT-AVILTNRTGFNLQEEPVFYISILIADN 555
D + + F + ++++TI N ++IL + + + + I++ + DN
Sbjct: 616 DADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGD---YKINLKLMDN 672
Query: 556 GIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLT 615
+ TL + VCDC G+ C+ + V G + I+ IL I+ + I L
Sbjct: 673 --QNKDQVTTLEVSVCDC--EGAAGVCRKAQPV-EAGLQIPAILGILGGILALLILILLL 727
Query: 616 LGLKQRR---KQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRK 672
L +RR K+ L P + +D R+N++ YD+EGGGEED + FD+++L R TR
Sbjct: 728 LLFLRRRAVVKEPLLPPE-DDTRDNVYYYDEEGGGEEDQD-FDLSQLHRGLDARPEVTRN 785
Query: 673 TTSAEIRSLYRQSLQ-VGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAG 731
+ + S+ R + PD FI E L+ A+TDP APP+DSL + +EG+GS A
Sbjct: 786 DVAPTLMSVPRYLPRPANPDE--IGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAA 843
Query: 732 SLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
SLSSL S+ SD+D+ YDYLNE G RFK+LA M+G
Sbjct: 844 SLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 877
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 307 bits (787), Expect = 2e-83
Identities = 240/753 (31%), Positives = 367/753 (48%), Gaps = 59/753 (7%)
Query: 40 RVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGS----TFIIDE 94
R KR WV VPE + QL+S+ D F Y + G GA S F +++
Sbjct: 104 RHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIF-YSITGPGADSPPEGVFAVEK 162
Query: 95 RTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYE 154
TG + + LDREE + Y L + G +VE I V+D ND++PKF + +
Sbjct: 163 ETGWLLLNKPLDREEIAKYELFGHAVS-ENGASVEDPMNISIIVTDQNDHKPKFTQDTFR 221
Query: 155 AIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP------YFSVEPTTGVIR- 207
V E GT V+QVTA+D DD N + YS+ +P F++ +TG I
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281
Query: 208 ISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSV-LIKLSDVNDNKPIFKESLYRLTVS 266
ISS +DRE EY + IQA DM G S TT+V ++++ D NDN P+F Y V
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDGDG---STTTAVAVVEILDANDNAPMFDPQKYEAHVP 338
Query: 267 ESAPTGTSIGTIMAYDNDIGENAEMDYS---IEEDDSQTFDIITNHETQEGIVILKKKVD 323
E+A G + + D D + + + DD F I T+ E+ +GI+ +K +D
Sbjct: 339 ENA-VGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLD 397
Query: 324 FEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEET 383
FE +N + + +V N E ST I + VEDV+E P+F+ P V EV E
Sbjct: 398 FEAKNQHTLYVEVTN----EAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGI 453
Query: 384 PQGSFVGVVSATDPDNRKSPIRYSITRSKVFNIN---DNGTITTSNSLDREISAW----- 435
P G V V +A DPD I Y I R + D+G +T +LDRE +
Sbjct: 454 PTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNI 513
Query: 436 YNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVD 495
Y + + A + + + L + ++++NDH P + + +C + QV+
Sbjct: 514 YEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGP-VPEPRQITICNQSPVRQVLNIT---- 568
Query: 496 RDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADN 555
D+ + H F + D ++ +T N++ V+L+ + ++ + + + ++D+
Sbjct: 569 -DKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLK---KFLKQDTYDVHLSLSDH 624
Query: 556 GIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLT 615
G + + VCDC G +TC GF V+ A+L + ++ + L
Sbjct: 625 G--NKEQLTVIRATVCDC--HGHVETCPGP---WKGGFILPVLGAVLALLFLLLVLLLLV 677
Query: 616 LGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTS 675
++ ++ +L PE +D R+N+F Y +EGGGEED + +DI +L R +
Sbjct: 678 RKKRKIKEPLLLPE--DDTRDNVFYYGEEGGGEEDQD-YDITQLHRGLEARPEVVLRNDV 734
Query: 676 AEI---RSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGS 732
A +YR PD FI+E L+ ANTDP APP+D+L + +EG+GS A S
Sbjct: 735 APTIIPTPMYRPR-PANPDE--IGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAAS 791
Query: 733 LSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
LSSL S+ SDQD+ YDYLNE G RFK+LA M+G
Sbjct: 792 LSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 824
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 306 bits (785), Expect = 4e-83
Identities = 246/765 (32%), Positives = 373/765 (48%), Gaps = 57/765 (7%)
Query: 40 RVKRGWVWNQFFVPEEMNTT-SHHIGQLRSDLDNGNNSFQYKLLGAGAGST----FIIDE 94
R KR WV +PE + ++RSD D N S +Y + G GA FII+
Sbjct: 156 RQKRDWVIPPINLPENSRGPFPQELVRIRSDRDK-NLSLRYSVTGPGADQPPTGIFIINP 214
Query: 95 RTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYE 154
+G + + LDRE+ + + LRA +DI G VE + VI V D+NDN P+FL + +
Sbjct: 215 ISGQLSVTKPLDREQIARFHLRAHAVDI-NGNQVENPIDIVINVIDMNDNRPEFLHQVWN 273
Query: 155 AIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP------YFSVEPTTG-VIR 207
VPE S GT V+ VTA DADDP++ N L Y ++ P F++ TG +I
Sbjct: 274 GTVPEGSKPGTYVMTVTAIDADDPNA-LNGMLRYRIVSQAPSTPSPNMFTINNETGDIIT 332
Query: 208 ISSKMDRELQDEYWVIIQAKDMIGQPG-ALSGTTSVLIKLSDVNDNKPIFKESLYRLTVS 266
+++ +DRE +Y +IIQA DM G P LS T + +I ++DVNDN P F + V
Sbjct: 333 VAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP 392
Query: 267 ESAPTGTSIGTIMAYDNDIGENAEMD--YSIEEDD-SQTFDIITNHETQEGIVILKKKVD 323
E+ + + D D + Y I D + F I T+ + +G+V + K +D
Sbjct: 393 ENR-VDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPID 451
Query: 324 FEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEET 383
FE + + +N VP H ST + + V DV+E P F + E
Sbjct: 452 FETNRMFVLTVAAENQ-VPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGL 510
Query: 384 PQGSFVGVVSATDPDN-RKSPIRYSITRSKV--FNIND-NGTITTSNSLDREI----SAW 435
G+ + +A DPD + IRY+ I+ NG ITT LDRE +
Sbjct: 511 HAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNI 570
Query: 436 YNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVD 495
YN + A++ + L + +L+IND+AP+ E CE + I+A+D
Sbjct: 571 YNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQ-EAETCETPDPNSI--NITALD 627
Query: 496 RDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADN 555
D F F+L + I + L + F E ++ + I+I D+
Sbjct: 628 YDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKF--LEAGIYEVPIIITDS 685
Query: 556 GIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLT 615
G P ++ + L + VC C +G C + ++ G T IIAIL+CI+I+ + +
Sbjct: 686 GNPPKSNISILRVKVCQCDSNGD---CTDVDRIVGAGLGTGAIIAILLCIIILLILVLMF 742
Query: 616 LGLKQRR------KQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMR--- 666
+ +RR KQ+L + +D R+NI +YD+EGGGEED + +D+++L+ +
Sbjct: 743 VVWMKRRDKERQAKQLLI-DPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPDTVEPDA 800
Query: 667 ------ERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQT 720
R + AE + R + P FI E L+ A+ DP APP+DSL
Sbjct: 801 IKPVGIRRMDERPIHAEPQYPVRSA---APHPGDIGDFINEGLKAADNDPTAPPYDSLLV 857
Query: 721 YAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
+ +EG+GS AGSLSSL S+ S ++ YDYLN+ GPRFK+LA M+G
Sbjct: 858 FDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 301 bits (770), Expect = 2e-81
Identities = 231/753 (30%), Positives = 355/753 (47%), Gaps = 40/753 (5%)
Query: 40 RVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGS----TFIIDER 95
RV+R WV V E + + Q++SD S Y + G G F ID+
Sbjct: 42 RVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQ-LGSVIYSIQGPGVDEEPRGVFSIDKF 100
Query: 96 TGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEA 155
TG ++ LDRE+ + LRA +D+ G +E ++ I V D NDN P FL E +
Sbjct: 101 TGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEAFTG 159
Query: 156 IVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP-YFSVEPTTGVIR-ISSKMD 213
V E + GT V + A+DADDP + N A L QG P FS++ TG IR + +D
Sbjct: 160 RVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLD 219
Query: 214 RELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGT 273
RE+ Y + +Q DM G L+ T S +I L D+NDN P F + + E A +G
Sbjct: 220 REVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIE-AVSGV 276
Query: 274 SIGTIMAYDNDI--GENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKVDFEHQNHY 330
+G + D D+ N ++I E D F I T+ +T EG++ + K +D+E HY
Sbjct: 277 DVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHY 336
Query: 331 GIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVG 390
++ V+N P Q E +++ V+D +EPP+F + E P G+ V
Sbjct: 337 ELKVSVQNE-APLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVA 395
Query: 391 VVSATDPDNRKSPIRYSITRSKVFNIND-------NGTITTSNSLDREI----SAWYNLS 439
SA DPD + ++ SK ++ D G I T + L WY
Sbjct: 396 TFSARDPDTEQLQ---RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
Query: 440 ITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDES 499
+ A + + + ++ L +++L +NDHAP + +C G + + A D D
Sbjct: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLP 511
Query: 500 IEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPS 559
F+F LS + + + L R + E + +S+L+ D+G P
Sbjct: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPR---HQVPEGLHRLSLLLRDSGQPP 568
Query: 560 LTSTNTLTIHVCDCGDSGSTQTCQYQELV----LSMGFKTEVIIAILICIMIIFGFIFLT 615
L + VC CG G L LS+G V+ + L+ ++++
Sbjct: 569 QQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRA 628
Query: 616 LGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRER--KTRKT 673
KQ R + L +D R+N+ YD++GGGEED +A+DI++LR T +
Sbjct: 629 RFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLR 688
Query: 674 TSAEIRSLYRQSLQVGPDSAI-FRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGS 732
A L+ Q +V P S + FI + LE A++DP PP+D+ Y +EG GS+AG+
Sbjct: 689 RDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGT 748
Query: 733 LSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
LSS+ S+ D+D+ YDYL + GPRF RLA M+G
Sbjct: 749 LSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 233 bits (593), Expect = 7e-61
Identities = 173/552 (31%), Positives = 268/552 (48%), Gaps = 29/552 (5%)
Query: 35 VRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNG-NNSFQYKLLGAGAGSTFIID 93
V +H+ R + V E S I +DLD G N Y + G S F+ID
Sbjct: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
Query: 94 ERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPY 153
TG + + LDRE Y L V D+ + V+ V D NDN P+FL E Y
Sbjct: 769 METGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVV-DANDNPPEFLQESY 827
Query: 154 EAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMD 213
V E + +IQV A+D D G N + YS++ FS++ TGV+ I+ +D
Sbjct: 828 FVEVSEDKEVHSEIIQVEATDKD---LGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLD 884
Query: 214 RELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGT 273
RELQ E+ + I+A+D + L T V + L DVNDN P F YR+ V E P GT
Sbjct: 885 RELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGT 944
Query: 274 SIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIR 333
I + A+D D+G++ ++ YS+ + FD+ + G V + +++DFE + Y +
Sbjct: 945 VIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDV----DKLSGAVRIVQQLDFEKKQVYNLT 1000
Query: 334 AKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDE---PPLFLLPYYVFEVFEETPQGSFVG 390
+ K+ P L +ST +++++V DV+E PP+F V E+ P GS V
Sbjct: 1001 VRAKDKGKPVSL------SSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVM 1054
Query: 391 VVSATDPDNRK-SPIRYSITRSK---VFNI-NDNGTITTSNSLDREISAWYNLSITATEK 445
VSA D D R+ IRYSI VF I + G I TS+ LDRE ++ Y L++ AT++
Sbjct: 1055 TVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQ 1114
Query: 446 YNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRDESIEEHH 504
+ S I +Y++V ++ND+AP+ S+ Y + EN+ + I A D D S +
Sbjct: 1115 GVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
Query: 505 FYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTN 564
Y + N F I T +I T + +++ + + + DNG P ++
Sbjct: 1175 MY---KITSGNPQGFFSI--HPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIA 1229
Query: 565 TLTIHVCDCGDS 576
+ + + D D+
Sbjct: 1230 RVIVKILDENDN 1241
Score = 202 bits (513), Expect = 1e-51
Identities = 148/508 (29%), Positives = 251/508 (49%), Gaps = 34/508 (6%)
Query: 74 NNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESE 133
N Y LLG+GA F ++ TG++ LDREE+++Y L + D G ++
Sbjct: 3055 NAEITYTLLGSGA-EKFKLNPDTGELKTSTPLDREEQAVYHLLVRATD---GGGRFCQAS 3110
Query: 134 FVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQG 193
V+ + D+NDN P+F +PY V E + GTL+ +V A+DAD +G N ++LYSL+
Sbjct: 3111 IVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD---AGLNRKILYSLIDS 3167
Query: 194 QP-YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDN 252
FS+ +G+I++ +DRELQ Y + ++A D G P L+ T +V++ + D+NDN
Sbjct: 3168 ADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ-GLPRRLTATGTVIVSVLDINDN 3226
Query: 253 KPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIITNHET 311
P+F+ Y TVSE GT + + A DI NAE+ YSI ++ F I ++
Sbjct: 3227 PPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSI----DS 3282
Query: 312 QEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLF 370
+ G V + + +D+E + Y + + + P + + + V D+ D P+F
Sbjct: 3283 KTGAVFIIENLDYESSHEYYLTVEATDGGTPSL-------SDVATVNVNVTDINDNTPVF 3335
Query: 371 LLPYYVFEVFEETPQGSFVGVVSATDPDN-RKSPIRYSI---TRSKVFNIND-NGTITTS 425
Y + E+ V V A D D S I YSI + F I+ G + +
Sbjct: 3336 SQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVT 3395
Query: 426 NSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGS 484
LDRE + Y L++ A++ + ++++ + + V ++ND+AP FS+ Y + EN
Sbjct: 3396 KLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPV 3455
Query: 485 GQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEP 544
G + + D D S F+F + V + +F + N +L + +E+
Sbjct: 3456 GFSVLQLVVTDEDSSHNGPPFFFTI-VTGNDEKAFEV-----NPQGVLLTSSAIKRKEKD 3509
Query: 545 VFYISILIADNGIPSLTSTNTLTIHVCD 572
+ + + +ADNG P L+S + I V +
Sbjct: 3510 HYLLQVKVADNGKPQLSSLTYIDIRVIE 3537
Score = 174 bits (440), Expect = 4e-43
Identities = 158/522 (30%), Positives = 239/522 (45%), Gaps = 43/522 (8%)
Query: 68 SDLDNGNNSFQYKLLGAGAGSTFIID--ERTGDIYAIQKLDREERSLYILRAQVIDIATG 125
+D + N Y + G F ++ + +Y + LDRE+R Y+L AT
Sbjct: 2945 ADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTIT----ATD 3000
Query: 126 RAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNAR 185
++ +KV D NDN P Y +PE G L++Q++A+DAD S NA
Sbjct: 3001 GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRS---NAE 3057
Query: 186 LLYSLL-QGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLI 244
+ Y+LL G F + P TG ++ S+ +DRE Q Y ++++A D G S+++
Sbjct: 3058 ITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATD----GGGRFCQASIVL 3113
Query: 245 KLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFD 304
L DVNDN P F Y +TV E+ GT + + A D D G N ++ YS+ + F
Sbjct: 3114 TLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFS 3173
Query: 305 IITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV 364
I GI+ L+K +D E Q Y + K + +P +L +T + + V D+
Sbjct: 3174 I----NELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRL------TATGTVIVSVLDI 3223
Query: 365 -DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITRSKV---FNINDN 419
D PP+F Y V E+ G+ V V A D + I YSI F+I+
Sbjct: 3224 NDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK 3283
Query: 420 -GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETY 477
G + +LD E S Y L++ AT+ + V V +IND+ P FSQ Y T
Sbjct: 3284 TGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTV 3343
Query: 478 VCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNN-SSFTIIDNQDNTAVILTNRT 536
+ E+A Q + T+ A D D H Y S+ D N SSFTI + V
Sbjct: 3344 ISEDAVLEQSVITVMADDADGPSNSHIHY---SIIDGNQGSSFTIDPVRGEVKVTKL--- 3397
Query: 537 GFNLQEEPV--FYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
L E + + +++ +DNG P +T T+ I V D D+
Sbjct: 3398 ---LDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDN 3436
Score = 171 bits (433), Expect = 2e-42
Identities = 157/502 (31%), Positives = 243/502 (48%), Gaps = 47/502 (9%)
Query: 89 TFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPE--SEFVIKVS--DINDN 144
TF ID TG + + LDRE + + L+ + D A EP+ S V+KVS D+NDN
Sbjct: 867 TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE---EPQLFSTVVVKVSLEDVNDN 923
Query: 145 EPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQ-GQPYFSVEPTT 203
P F+ Y V E PEGT+++ + +A DP G + ++ YSLL G+ F V+ +
Sbjct: 924 PPTFIPPNYRVKVREDLPEGTVIMWL---EAHDPDLGQSGQVRYSLLDHGEGNFDVDKLS 980
Query: 204 GVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDN--KPIFKESLY 261
G +RI ++D E + Y + ++AKD G+P +LS T V +++ DVN+N P+F +
Sbjct: 981 GAVRIVQQLDFEKKQVYNLTVRAKDK-GKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
Query: 262 RLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKK 321
+ TV E AP G+ + T+ A+D D + E+ YSI D S ET G++ +
Sbjct: 1040 KGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR-DGSGVGVFKIGEET--GVIETSDR 1096
Query: 322 VDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVF 380
+D E +HY + + V +S I I+VEDV D P P Y E+
Sbjct: 1097 LDRESTSHYWLTVFATDQGVVPL-------SSFIEIYIEVEDVNDNAPQTSEPVYYPEIM 1149
Query: 381 EETPQGSFVGVVSATDPDNRKSP-IRYSITRSK---VFNINDNGTI--TTSNSLDREISA 434
E +P+ V + A DPD+ + + Y IT F+I+ + TTS LDRE
Sbjct: 1150 ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQD 1209
Query: 435 WYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYY--------ETYVCENAGSGQ 486
+ L +T T+ + + + + V++L+ ND+ P+F Q + E E +
Sbjct: 1210 EHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARRE 1269
Query: 487 VIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVF 546
+ + A D+DE Y S+ED N I + T V+ + R F+ E
Sbjct: 1270 PLYHVIATDKDEGPNAEISY---SIEDGNEHGKFFI--EPKTGVVSSKR--FSAAGE-YD 1321
Query: 547 YISILIADNGIPSLTSTNTLTI 568
+SI DNG P +ST L I
Sbjct: 1322 ILSIKAVDNGRPQKSSTTRLHI 1343
Score = 169 bits (428), Expect = 9e-42
Identities = 159/547 (29%), Positives = 249/547 (45%), Gaps = 53/547 (9%)
Query: 51 FVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAG----STFIIDERTGDIYAIQKLD 106
F+ E + S I SD D+G N L +F I+ TG I +++LD
Sbjct: 2817 FIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELD 2876
Query: 107 REERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTL 166
E+R Y ++ D + + + V+D+ND+ P+F E Y+ V E P+G +
Sbjct: 2877 HEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGV 2936
Query: 167 VIQVTASDADDPSSGNNARLLYSLLQGQPY--FSVEPTTGVIRISSK--MDRELQDEYWV 222
+ ++ +DAD S N ++ Y + G P F+VE ++ K +DRE +D Y +
Sbjct: 2937 IAILSTTDAD--SEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLL 2994
Query: 223 IIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYD 282
I A D G S V +K+ D NDN P+ +++LY T+ E G I I A D
Sbjct: 2995 TITATD-----GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATD 3049
Query: 283 NDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVP 342
DI NAE+ Y++ ++ F + N +T G + +D E Q Y
Sbjct: 3050 ADIRSNAEITYTLLGSGAEKFKL--NPDT--GELKTSTPLDREEQAVY------------ 3093
Query: 343 EQLMKYHTEASTTF----IKIQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDP 397
L+ T+ F I + +EDV D P F Y VFE T G+ + V ATD
Sbjct: 3094 -HLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDA 3152
Query: 398 D---NRKSPIRYSITRSK--VFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
D NRK I YS+ S F+IN+ +G I LDRE+ A Y LS+ A ++ ++
Sbjct: 3153 DAGLNRK--ILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRL 3210
Query: 452 SSI-PLYVQVLNINDHAPEFS-QYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNL 509
++ + V VL+IND+ P F + Y V E+ G + + A RD Y
Sbjct: 3211 TATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITY--- 3267
Query: 510 SVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIH 569
S+ N ID++ I+ N + + +Y+++ D G PSL+ T+ ++
Sbjct: 3268 SIISGNEHGKFSIDSKTGAVFIIEN---LDYESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
Query: 570 VCDCGDS 576
V D D+
Sbjct: 3325 VTDINDN 3331
Score = 163 bits (412), Expect = 6e-40
Identities = 146/544 (26%), Positives = 249/544 (45%), Gaps = 53/544 (9%)
Query: 51 FVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREER 110
F E + +H IG + ++ + + G S F +D+ TG I + LD E++
Sbjct: 1365 FTVMESDPVAHMIGVI--SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQK 1422
Query: 111 SLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQV 170
S Y L + D T ++ IKV D ND+ P+F YE ++PE + T ++Q+
Sbjct: 1423 SNYNLTVEATDGTTTIL----TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQI 1478
Query: 171 TASDADDPSSGNNARLLYSLLQGQP-----YFSVEPTTGVIRISSKMDRELQDEYWVIIQ 225
+A D D+ + +L+Y+L + F ++P TG + S K+D E ++ + +
Sbjct: 1479 SAVDQDEKN-----KLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVM 1533
Query: 226 AKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDI 285
+D +++ +SD ND+ P F S Y+ V ESA G+ + + A D D
Sbjct: 1534 VRDQ--DVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591
Query: 286 GENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQL 345
G+NAE+ YSIE + +I + G + K++D +Q Y + K + P
Sbjct: 1592 GKNAEVLYSIESGNIGNSFMI---DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPM- 1647
Query: 346 MKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIR 405
+E ++ I + + D + P F Y E+ E GSFVG+V+A + +S +
Sbjct: 1648 ----SEITSVRIFVTIAD-NASPKFTSKEYSVELSETVSIGSFVGMVTA----HSQSSVV 1698
Query: 406 YSI---TRSKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVL 461
Y I F+IN +GTI T +LD E Y L I T + +++ +++Q
Sbjct: 1699 YEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQ-- 1756
Query: 462 NINDHAPEFSQ-YYETYVCENAGSGQVIQT-------ISAVDRDESIEEHHFYFNLSVED 513
+ ND+AP F Q Y + E+A V+ T I A D D+ Y VE
Sbjct: 1757 DENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH--IVEP 1814
Query: 514 TNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTS--TNTLTIHVC 571
+ ++ F I D++ + + +E +F+ ++ + D G P L + +T+HV
Sbjct: 1815 SVHTYFAI----DSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870
Query: 572 DCGD 575
D D
Sbjct: 1871 DIND 1874
Score = 158 bits (400), Expect = 2e-38
Identities = 136/490 (27%), Positives = 219/490 (44%), Gaps = 26/490 (5%)
Query: 79 YKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKV 138
Y + S F I+ TG I I LD E Y L + D TG E + + V
Sbjct: 2216 YSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDII--V 2273
Query: 139 SDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDAD-DPSSGNNARLLYSLLQGQPYF 197
DINDN P F + Y + E S GT V+QV A+D+D +P+ G + ++ + + +F
Sbjct: 2274 DDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHF 2333
Query: 198 SVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFK 257
V+ +TG+I + +D E ++ + ++A D G LS V + ++D+NDN P+F+
Sbjct: 2334 HVDSSTGLISLLRTLDYEQSRQHTIFVRAVD--GGMPTLSSDVIVTVDVTDLNDNPPLFE 2391
Query: 258 ESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVI 317
+ +Y +SE AP G + + AYD D + ++ YSI + +I ++ GI+
Sbjct: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVI---DSATGIIT 2448
Query: 318 LKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVF 377
L + Y + N V + + + T+ T I + P FL Y
Sbjct: 2449 LSNLHRHALKPFYSL-----NLSVSDGVFRSSTQVHVTVIGGNLHS----PAFLQNEYEV 2499
Query: 378 EVFEETPQGSFVGVVSATDPDNR-KSPIRYSITRSKV---FNINDNGTITTSNSLDREIS 433
E+ E P + V V TD D+ + Y I F IN+ G I T LDRE
Sbjct: 2500 ELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETP 2559
Query: 434 AWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTIS 492
A +S+ K +++ + V + + ND+AP+F + YE + +A G + +
Sbjct: 2560 AEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVL 2619
Query: 493 AVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILI 552
A D DE Y ++E + S ++ + VI T + L+ E F +
Sbjct: 2620 ASDADEGSNADITY---AIEADSESVKENLEINKLSGVITTKESLIGLENE-FFTFFVRA 2675
Query: 553 ADNGIPSLTS 562
DNG PS S
Sbjct: 2676 VDNGSPSKES 2685
Score = 155 bits (393), Expect = 1e-37
Identities = 128/442 (28%), Positives = 211/442 (47%), Gaps = 30/442 (6%)
Query: 68 SDLDNG-NNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
+D D G N Y L+ + G F I+E +G I + LDRE +++Y L + +D R
Sbjct: 3150 TDADAGLNRKILYSLIDSADGQ-FSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPR 3208
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
+ ++ V DINDN P F Y A V E GT V+QV A+ D + NA +
Sbjct: 3209 RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEA---NAEI 3265
Query: 187 LYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLI 244
YS++ G + FS++ TG + I +D E EY++ ++A D G +LS +V +
Sbjct: 3266 TYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD--GGTPSLSDVATVNV 3323
Query: 245 KLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYS-IEEDDSQTF 303
++D+NDN P+F + Y +SE A S+ T+MA D D N+ + YS I+ + +F
Sbjct: 3324 NVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSF 3383
Query: 304 DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED 363
I + G V + K +D E + Y + + ++ P ++ +TT + I V D
Sbjct: 3384 TI----DPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRV-------NTTTVNIDVSD 3432
Query: 364 V-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKS--PIRYSITR---SKVFNIN 417
V D P+F Y + E P G V + TD D+ + P ++I K F +N
Sbjct: 3433 VNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVN 3492
Query: 418 DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETY 477
G + TS+++ R+ Y L + + + S + ++V+ + + P E +
Sbjct: 3493 PQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILP-LEIF 3551
Query: 478 VCENAG--SGQVIQTISAVDRD 497
+ + SG VI I A D+D
Sbjct: 3552 ITSSGEEYSGGVIGKIHATDQD 3573
Score = 139 bits (349), Expect = 1e-32
Identities = 137/559 (24%), Positives = 233/559 (41%), Gaps = 62/559 (11%)
Query: 68 SDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREE-RSLYILRAQVIDIATGR 126
SD+D QY +L F+ID TG I + L R + Y L V D
Sbjct: 2420 SDIDK----LQYSILSGNDHKHFVIDSATG-IITLSNLHRHALKPFYSLNLSVSD----G 2470
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
++ + V N + P FL YE + E +P TLV++V +D D G+
Sbjct: 2471 VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYH 2530
Query: 187 LYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKL 246
+ + ++ E G I K+DRE E +I + M G +V + L
Sbjct: 2531 IVNDFAKDRFYINE--RGQIFTLEKLDRETPAEK--VISVRLMAKDAGGKVAFCTVNVIL 2586
Query: 247 SDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDII 306
+D NDN P F+ + Y + + SA GTS+ ++A D D G NA++ Y+IE D + +
Sbjct: 2587 TDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENL 2646
Query: 307 TNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDE 366
++ G++ K+ + + + ++ P + ++KI ++ +
Sbjct: 2647 EINKL-SGVITTKESLIGLENEFFTFFVRAVDNGSPSK-----ESVVLVYVKILPPEM-Q 2699
Query: 367 PPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNIN--------- 417
P F P+Y F V E+ P G+ + ++ A + YS+ + N
Sbjct: 2700 LPKFSEPFYTFTVSEDVPIGTEIDLIRA----EHSGTVLYSLVKGNTPESNRDESFVIDR 2755
Query: 418 DNGTITTSNSLDREISAWYNLSITA-TEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYE 475
+G + SLD E + WY SI A + + E ++S+ + +QV + ND++P F S YE
Sbjct: 2756 QSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYE 2815
Query: 476 TYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVI---- 531
++ EN G + I A D D TN +D + VI
Sbjct: 2816 AFIVENLPGGSRVIQIRASDADSG--------------TNGQVMYSLDQSQSVEVIESFA 2861
Query: 532 -------LTNRTGFNLQEEPVFYISILIADNGIP-SLTSTNTLTIHVCDCGDSGSTQTCQ 583
+T + ++ + I ++ +D+G L+ST + + V D DS T +
Sbjct: 2862 INMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAE 2921
Query: 584 YQELVLSMGFKTEVIIAIL 602
+ +S +IAIL
Sbjct: 2922 IYKGTVSEDDPQGGVIAIL 2940
Score = 116 bits (290), Expect = 9e-26
Identities = 113/463 (24%), Positives = 205/463 (44%), Gaps = 50/463 (10%)
Query: 72 NGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPE 131
+ +S Y++ G F I+ +G I + LD E +Y L Q ++A +
Sbjct: 1692 HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA---GLSTN 1748
Query: 132 SEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQ-------VTASDADDPSSGNNA 184
+ ++ + D NDN P F+ Y ++ E + ++V+ + A+DAD S NA
Sbjct: 1749 TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS---NA 1805
Query: 185 RLLYSLLQGQ--PYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSG-TTS 241
L+Y +++ YF+++ +TG I +D E + +Q DM G P + +
Sbjct: 1806 LLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDM-GTPRLFAEYAAN 1864
Query: 242 VLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDD-S 300
V + + D+ND P+F + LY ++ G + T+ A D D +++ YSI E +
Sbjct: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIG 1924
Query: 301 QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ 360
+ F + + + G + ++ + +RA A T +KI
Sbjct: 1925 EKFSM----DYKTGALTVQNTTQLRSRYELTVRASDGRF------------AGLTSVKIN 1968
Query: 361 VEDVDEPPL-FLLPYYVFEVFEETPQGSFVGVVSAT-DPDNRKSPIRYSITR-SKVFNIN 417
V++ E L F Y V E + + + V++A +P N P+ Y I + F I+
Sbjct: 1969 VKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRRFKIS 2026
Query: 418 DNGTI--TTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQY-Y 474
+ TT DRE +++ + TE++ ++ + + V V + ND+AP F Y
Sbjct: 2027 RTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY 2086
Query: 475 ETYVCENAGSGQVIQTISAVDRDES--------IEEHHFYFNL 509
V + G VI+ ++AVDRD ++EHH +F +
Sbjct: 2087 YAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI 2129
Score = 110 bits (274), Expect = 6e-24
Identities = 135/511 (26%), Positives = 215/511 (42%), Gaps = 53/511 (10%)
Query: 79 YKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKV 138
Y + G F +D +TG + +Q + RS Y L + D GR S I V
Sbjct: 1916 YSITEGNIGEKFSMDYKTGAL-TVQNTT-QLRSRYELTVRASD---GRFAGLTS-VKINV 1969
Query: 139 SDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGN--NARLLYSLLQGQPY 196
+ ++ KF + Y A+V E S E + +TA GN N L Y +L
Sbjct: 1970 KESKESHLKFTQDVYSAVVKENSTEAETLAVITAI-------GNPINEPLFYHILNPDRR 2022
Query: 197 FSVEPTTGVIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPI 255
F + T+GV+ + + DRE Q+ + V+++ + +P A++ V + + D NDN P+
Sbjct: 2023 FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEE-HKPSAVAHVV-VKVIVEDQNDNAPV 2080
Query: 256 FKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQE-- 313
F Y V G I + A D D G N E+ Y ++E +HE +
Sbjct: 2081 FVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKE----------HHEHFQIG 2130
Query: 314 --GIVILKKKVDFEHQN-HYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLF 370
G + LKK+ + + N Y + K+ P ++ + I V + P+F
Sbjct: 2131 PLGEISLKKQFELDTLNKEYLVTVVAKDGGNP-------AFSAEVIVPITVMN-KAMPVF 2182
Query: 371 LLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRS---KVFNINDN-GTITTSN 426
P+Y E+ E S V V A P+ K + YSIT F IN N G I
Sbjct: 2183 EKPFYSAEIAESIQVHSPVVHVQANSPEGLK--VFYSITDGDPFSQFTINFNTGVINVIA 2240
Query: 427 SLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQY-YETYVCENAGSG 485
LD E Y LSI AT+ + + + + V +IND+ P F+Q Y + E + G
Sbjct: 2241 PLDFEAHPAYKLSIRATDSLTGAH-AEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG 2299
Query: 486 QVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPV 545
+ + A D D Y ++ F + +T +I RT + ++
Sbjct: 2300 TSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHV---DSSTGLISLLRT-LDYEQSRQ 2355
Query: 546 FYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
I + D G+P+L+S +T+ V D D+
Sbjct: 2356 HTIFVRAVDGGMPTLSSDVIVTVDVTDLNDN 2386
Score = 95.9 bits (237), Expect = 1e-19
Identities = 117/466 (25%), Positives = 203/466 (43%), Gaps = 39/466 (8%)
Query: 105 LDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEG 164
L+RE + Y L + ++ T VE ++ ++V D ND P F Y +PE +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN--VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 165 TLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVII 224
T + +V+A+DAD G N YS F++ PT+GVI ++ ++D Y + I
Sbjct: 166 TSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEI 222
Query: 225 QAKD----MIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMA 280
A D + G G +S + + + N+ P+ + +T+S S I+
Sbjct: 223 LAADRGMKLYGSSG-ISSMAKLTVHIEQANECAPV----ITAVTLSPSELDRDPAYAIVT 277
Query: 281 YDN-DIGENAEM-DYSIEEDD-SQTFDIITNHE-TQEGIVILKKKVDFE-HQNHYGIRAK 335
D+ D G N ++ SI D Q F + + ++E V +D++ H Y + +
Sbjct: 278 VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQ 337
Query: 336 VKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPL-FLLPYYVFEVFEETPQGSFVGVVSA 394
K+ P Q +S I + P+ F Y E+ E P + V +V A
Sbjct: 338 AKDKGTPPQF------SSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Query: 395 TDPDNRKSPIRYSITRSKVFNINDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISS 453
+ + S F++N N G I+ + R+ +A + L +T +++ +S
Sbjct: 392 IPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----AS 446
Query: 454 IPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVE 512
+ V+VL N + PEF+Q Y+ EN G + ++SAVD DE + Y S+
Sbjct: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEG---ENGYVTYSIA 503
Query: 513 DTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIP 558
+ N+ F I + AV + + L V+ + I +D G+P
Sbjct: 504 NLNHVPFAI--DHFTGAVSTSENLDYELMPR-VYTLRIRASDWGLP 546
Score = 95.5 bits (236), Expect = 2e-19
Identities = 135/540 (25%), Positives = 219/540 (40%), Gaps = 74/540 (13%)
Query: 90 FIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFL 149
F ++ TG I ++ + R++ + + L D V ++KV N N P+F
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKV------LVKVLGANSNPPEFT 464
Query: 150 DEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQ-GQPYFSVEPTTGVIRI 208
Y+A E P GT V+ ++A DP G N + YS+ F+++ TG +
Sbjct: 465 QTAYKAAFDENVPIGTTVMSLSAV---DPDEGENGYVTYSIANLNHVPFAIDHFTGAVST 521
Query: 209 SSKMDRELQDE-YWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSE 267
S +D EL Y + I+A D G P I L+++NDN P+F++ T+
Sbjct: 522 SENLDYELMPRVYTLRIRASDW-GLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPR 580
Query: 268 SAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKK------- 320
G I T+ A D D E + Y IE + F + G++ LK+
Sbjct: 581 DLGVGEQITTVSAIDAD--ELQLVQYQIEAGNELDFFSL---NPNSGVLSLKRSLMDGLG 635
Query: 321 -KVDFEH----------------------QNHYGIRAKVKNHHVPEQLMKYHTEASTTFI 357
KV F +H + + + V + L + +A+
Sbjct: 636 AKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHN 695
Query: 358 KIQVEDV--------DEPPLF--LLPYYVFEVFEETPQGSFVGVVSATDPDNR-KSPIRY 406
+ +VED+ P F LP + +V E P GS V +++TD D + Y
Sbjct: 696 QGEVEDIFFDSHSVNAHIPQFRSTLPTGI-QVKENQPVGSSVIFMNSTDLDTGFNGKLVY 754
Query: 407 SIT---RSKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLN 462
+++ F I+ + G + + LDRE + Y L+IT + ++ + L+V V++
Sbjct: 755 AVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVD 814
Query: 463 INDHAPEFSQYYETYVCENAGSGQV---IQTISAVDRDESIEEHHFYFNLSVEDTNNSSF 519
ND+ PEF Q E+Y E + +V I + A D+D H Y V DT+ S
Sbjct: 815 ANDNPPEFLQ--ESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTY--SIVTDTDTFSI 870
Query: 520 TIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGST 579
+ N A L LQ E I P L ST + + + D D+ T
Sbjct: 871 DSVTGVVNIARPLDR----ELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPT 926
Score = 87.4 bits (215), Expect = 4e-17
Identities = 112/485 (23%), Positives = 191/485 (39%), Gaps = 87/485 (17%)
Query: 147 KFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVI 206
KF + Y A + E +P T V+ V A A ++ R ++ G+ FS+ TG+I
Sbjct: 366 KFEKDVYRAEISEFAPPNTPVVMVKAIPAY-----SHLRYVFKSTPGKAKFSLNYNTGLI 420
Query: 207 RISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVS 266
I + R+ + + + D +T VL+K+ N N P F ++ Y+
Sbjct: 421 SILEPVKRQQAAHFELEVTTSDR-------KASTKVLVKVLGANSNPPEFTQTAYKAAFD 473
Query: 267 ESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEH 326
E+ P GT++ ++ A D D GEN + YSI + F I +H T G V + +D+E
Sbjct: 474 ENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAI--DHFT--GAVSTSENLDYEL 529
Query: 327 QNH-YGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQ 385
Y +R + + +P + + A+ T + D PLF + +
Sbjct: 530 MPRVYTLRIRASDWGLPYR-REVEVLATITLNNLN----DNTPLFEKINCEGTIPRDLGV 584
Query: 386 GSFVGVVSATDPDNRKSPIRYSITRSK---VFNINDN-GTITTSNSLDREISA---WYNL 438
G + VSA D D + ++Y I F++N N G ++ SL + A +++L
Sbjct: 585 GEQITTVSAIDADELQL-VQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSL 643
Query: 439 SITATEKYNIEQISSIPLYVQVL------------------------------------- 461
ITAT+ N + PLY+ +
Sbjct: 644 RITATDGENF----ATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEV 699
Query: 462 --------NINDHAPEFSQYYET--YVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSV 511
++N H P+F T V EN G + +++ D D Y +V
Sbjct: 700 EDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVY---AV 756
Query: 512 EDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
N S +ID + IL + + + + ++I + D GIP + L + V
Sbjct: 757 SGGNEDSCFMIDMETGMLKIL---SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVV 813
Query: 572 DCGDS 576
D D+
Sbjct: 814 DANDN 818
Score = 66.6 bits (161), Expect = 8e-11
Identities = 105/455 (23%), Positives = 178/455 (39%), Gaps = 54/455 (11%)
Query: 68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID----I 122
+D D G N F Y F I +G I +LD E LY + D +
Sbjct: 174 TDADIGTNGEFYYSF--KDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKL 231
Query: 123 ATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGN 182
+ ++ + + N+ P + P +V T D D ++G+
Sbjct: 232 YGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIV---TVDDCDQGANGD 288
Query: 183 NARLLYSLLQG---QPYFSVEPTTGVIRISSKMDRELQDE-----YWVIIQAKDMIGQPG 234
A L S++ G Q + +V G K + + Y + +QAKD G P
Sbjct: 289 IASL--SIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK-GTPP 345
Query: 235 ALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYS 294
S + + F++ +YR +SE AP T + + A I + + Y
Sbjct: 346 QFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA----IPAYSHLRYV 401
Query: 295 IEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEAST 354
+ + N+ T G++ + + V + H+ + + +AST
Sbjct: 402 FKSTPGKA-KFSLNYNT--GLISILEPVKRQQAAHFELEVTTSDR-----------KAST 447
Query: 355 TFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSP-IRYSITRSK- 412
+ + PP F Y E P G+ V +SA DPD ++ + YSI
Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNH 507
Query: 413 -VFNIND-NGTITTSNSLDREISAW-YNLSITATE-----KYNIEQISSIPLYVQVLNIN 464
F I+ G ++TS +LD E+ Y L I A++ + +E +++I L N+N
Sbjct: 508 VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLN----NLN 563
Query: 465 DHAPEFSQYY-ETYVCENAGSGQVIQTISAVDRDE 498
D+ P F + E + + G G+ I T+SA+D DE
Sbjct: 564 DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 207 bits (526), Expect = 4e-53
Identities = 154/518 (29%), Positives = 252/518 (48%), Gaps = 29/518 (5%)
Query: 69 DLDNG-NNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
D D+G N + + S F ID TG + + +DRE LY+L + D+ +
Sbjct: 752 DADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK 811
Query: 128 VEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLL 187
I V D NDN P F+ + Y + E S GT +IQV A D D G+N +
Sbjct: 812 SSWRL-LTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD---LGSNGEVT 867
Query: 188 YSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLS 247
YS+L F++ +TG++ ++ ++DRE + Y + I+A+D L ++ + L
Sbjct: 868 YSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLD 927
Query: 248 DVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIIT 307
DVND P F S Y + V E P GT I + +D D+G ++ YS+ D + F+I
Sbjct: 928 DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEI-- 985
Query: 308 NHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDE- 366
+ G + L K++D+E Q Y + + K+ P L +S +F++++V DV+E
Sbjct: 986 --DKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSL------SSVSFVEVEVVDVNEN 1037
Query: 367 --PPLFLLPYYVFEVFEETPQGSFVGVVSATDPDN-RKSPIRYSITRSK---VFNIND-N 419
P F V V E + G+ V V+A D D+ R I+YSI F+I+D +
Sbjct: 1038 LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDES 1097
Query: 420 GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYV 478
G IT ++ LDRE Y L++ AT++ + S+I +Y++V ++ND+AP S+ Y V
Sbjct: 1098 GVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVV 1157
Query: 479 CENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGF 538
EN+ + I A D D S E Y + N +F I+ + T +I T
Sbjct: 1158 MENSPKDVSVIQIQAEDPDSSSNEKLTY---RITSGNPQNFFAINIK--TGLITTTSRKL 1212
Query: 539 NLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+ +++ ++ + + D G ST + + V D D+
Sbjct: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDN 1250
Score = 172 bits (437), Expect = 8e-43
Identities = 151/527 (28%), Positives = 243/527 (46%), Gaps = 45/527 (8%)
Query: 69 DLDNGNNSFQYKLLGAGAGSTFIID--ERTGDIYAIQKLDREERSLYILRAQVID--IAT 124
D + N Y + G F + + +Y + LDREE+ +Y L D T
Sbjct: 2952 DTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVT 3011
Query: 125 GRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNA 184
VE + VSD+NDN P Y A++PE P ++++V+A DAD G+N
Sbjct: 3012 QAMVE------VSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDAD---IGSNG 3062
Query: 185 RLLYSLL-QGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVL 243
+ YSL G F ++P +G ++ + +DRE Y ++ +A D G +++
Sbjct: 3063 YIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATD----GGGRFCQSNIH 3118
Query: 244 IKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTF 303
+ L DVNDN P+F Y V E+ T + + A D DIG N ++ YS+ + F
Sbjct: 3119 LILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVF 3178
Query: 304 DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED 363
I ++ GI+IL++ +D E Q+ Y I + + + L +S T + I V D
Sbjct: 3179 SI----DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSL------SSLTTVTITVLD 3228
Query: 364 V-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITRSKV---FNIND 418
+ D PP+F Y+ V E+T G+ V V AT D + I Y I F IN
Sbjct: 3229 INDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINP 3288
Query: 419 N-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYET 476
G I+ S LD E+ + L + A + + + + + ++ND+ P+FSQ Y
Sbjct: 3289 KTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSA 3348
Query: 477 YVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRT 536
+ E+A G + + A D D S +F++ D +N FT+ V+ +
Sbjct: 3349 VISEDALVGDSVILLIAEDVD-SQPNGQIHFSIVNGDRDNE-FTV------DPVLGLVKV 3400
Query: 537 GFNLQEEPVFYISILI--ADNGIPSLTSTNTLTIHVCDCGDSGSTQT 581
L E V S+L+ D+GIP+++ST T+ I + D D+ T
Sbjct: 3401 KKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFT 3447
Score = 170 bits (430), Expect = 5e-42
Identities = 156/530 (29%), Positives = 252/530 (47%), Gaps = 60/530 (11%)
Query: 69 DLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
D D+G + QY + F ID+ +G I A LDRE Y L AT R
Sbjct: 1069 DEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTV----YATDRG 1124
Query: 128 VEP---ESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNA 184
V P E I+V D+NDN P + Y +V E SP+ VIQ+ A+DP S +N
Sbjct: 1125 VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI---QAEDPDSSSNE 1181
Query: 185 RLLYSLLQGQP--YFSVEPTTGVIRISS-KMDRELQDEYWVIIQAKDMIGQPGALSGTTS 241
+L Y + G P +F++ TG+I +S K+DRE Q E+++ + D G P T
Sbjct: 1182 KLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTD--GGPSPKQSTIW 1239
Query: 242 VLIKLSDVNDNKPIFKESLYRLTVSE--SAPTGTSIGTIMAYDNDIGENAEMDYSIEE-- 297
V++++ D NDNKP F E +Y++ + E G I A+D D G NAE+ YSI +
Sbjct: 1240 VVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGN 1299
Query: 298 DDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFI 357
DD + F + + G+V +K+ F ++ + K ++ P++ ++
Sbjct: 1300 DDGKFF-----IDPKTGMVSSRKQ--FTAGSYDILTIKAVDNGRPQK---------SSTA 1343
Query: 358 KIQVEDVDEPP------LFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRS 411
++ +E + +PP F P+Y F V E VGVVS P N +P+ + I
Sbjct: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVS-VQPAN--TPLWFDIVGG 1400
Query: 412 KVFNINDN----GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 467
+ D GTI + LD E + YN+S+ T+ N ++ ++++VL+ ND+
Sbjct: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN---VAVTQVFIKVLDNNDNG 1457
Query: 468 PEFSQ-YYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQD 526
PEFSQ Y+ + E+ I I A DRDE + + + S++ + F I
Sbjct: 1458 PEFSQPNYDVTISEDVLPDTEILQIEATDRDEK-HKLSYTVHSSIDSISMRKFRI---DP 1513
Query: 527 NTAVILT-NRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGD 575
+T V+ T R Q++ + ++I++ D P + + ++V D D
Sbjct: 1514 STGVLYTAERLDHEAQDKHI--LNIMVRDQEFPYRRNLARVIVNVEDAND 1561
Score = 169 bits (429), Expect = 7e-42
Identities = 135/442 (30%), Positives = 211/442 (47%), Gaps = 32/442 (7%)
Query: 69 DLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAV 128
D D G N L AG F ID +G I Q LDRE++S Y + + D + G+++
Sbjct: 3157 DPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSL 3216
Query: 129 EPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLY 188
+ I V DINDN P F Y VPE + GT V+ V A+ D G NA + Y
Sbjct: 3217 SSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD---IGTNAEITY 3273
Query: 189 SLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKL 246
+ G Q F + P TG I +S +D EL ++++++AKD G ALS +V I L
Sbjct: 3274 LIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKD--GGTPALSAVATVNINL 3331
Query: 247 SDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI---EEDDSQTF 303
+DVNDN P F + +Y +SE A G S+ ++A D D N ++ +SI + D+ T
Sbjct: 3332 TDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTV 3391
Query: 304 DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED 363
D + G+V +KKK+D E + Y + + + +P +ST + I + D
Sbjct: 3392 DPVL------GLVKVKKKLDRERVSGYSLLVQAVDSGIPAM-------SSTATVNIDISD 3438
Query: 364 V-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD--NRKSPIRYSI---TRSKVFNIN 417
V D P+F Y + E P G+ + + TD D + P +SI + F ++
Sbjct: 3439 VNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLD 3498
Query: 418 DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETY 477
+G + ++ S Y L + A + +Q+S + V+V+ + H P + E +
Sbjct: 3499 PHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPT-AIPLEIF 3557
Query: 478 V--CENAGSGQVIQTISAVDRD 497
+ E+ G VI I A D+D
Sbjct: 3558 IVTMEDDFPGGVIGKIHATDQD 3579
Score = 167 bits (423), Expect = 3e-41
Identities = 144/532 (27%), Positives = 243/532 (45%), Gaps = 37/532 (6%)
Query: 52 VPEEMNTTSHHIGQLRSDLDNGNNSF-QYKLLGAGAGSTFIIDERTGDIYAIQKLDREER 110
+PE++ + + D D G+N + +Y L G+G S F +D +G++ + LDRE
Sbjct: 3038 LPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG-NSEFFLDPESGELKTLALLDRERI 3096
Query: 111 SLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQV 170
+Y L A+ D GR + +++ D+NDN P F + Y V E + L+ +V
Sbjct: 3097 PVYSLMAKATD-GGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRV 3153
Query: 171 TASDADDPSSGNNARLLYSLLQGQ-PYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
A DP G N +++YSL FS++ ++G+I + +DRE Q Y + ++A D
Sbjct: 3154 ---QAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQ 3210
Query: 230 IGQPG-ALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGEN 288
PG +LS T+V I + D+NDN P+F+ Y +TV E GT + + A DIG N
Sbjct: 3211 --SPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTN 3268
Query: 289 AEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMK 347
AE+ Y I + Q F I + G + + + +D+E + + + K+ P
Sbjct: 3269 AEITYLIRSGNEQGKFKI----NPKTGGISVSEVLDYELCKRFYLVVEAKDGGTP----- 3319
Query: 348 YHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNR-KSPIR 405
++ + I + DV D PP F Y + E+ G V ++ A D D++ I
Sbjct: 3320 --ALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIH 3377
Query: 406 YSIT---RSKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVL 461
+SI R F ++ G + LDRE + Y+L + A + S+ + + +
Sbjct: 3378 FSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDIS 3437
Query: 462 NINDHAPEFS-QYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFT 520
++ND++P F+ Y + EN G I + DRD F F S+ N
Sbjct: 3438 DVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSF--SILSGNEEEEF 3495
Query: 521 IIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCD 572
++D IL + F E + + + D+G P S + + V +
Sbjct: 3496 VLDPHG----ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIE 3543
Score = 161 bits (408), Expect = 2e-39
Identities = 146/494 (29%), Positives = 231/494 (46%), Gaps = 38/494 (7%)
Query: 90 FIIDERTGDIYAIQKLDREERSLYILRAQVIDIA-TGRAVEPESEFVIKVSDINDNEPKF 148
F I+ TG +Y +LDRE ++ Y L+ + D A +G+ + + + D+ND P F
Sbjct: 877 FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF 936
Query: 149 LDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQG-QPYFSVEPTTGVIR 207
+ Y V E P GT++ + + DP G ++ YSL+ F ++ +G IR
Sbjct: 937 IPSSYSVKVLEDLPVGTVIAWL---ETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIR 993
Query: 208 ISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDN--KPIFKESLYRLTV 265
+S ++D E Q Y + ++AKD G+P +LS + V +++ DVN+N P F + +V
Sbjct: 994 LSKELDYEKQQFYNLTVRAKDK-GRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
Query: 266 SESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKVDF 324
E++ GTS+ + A D D G + E+ YSI + F I + + G++ +D
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSI----DDESGVITAADILDR 1108
Query: 325 EHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEET 383
E Y + + V ST + I+VEDV D PL P Y V E +
Sbjct: 1109 ETMGSYWLTVYATDRGVVPLY-------STIEVYIEVEDVNDNAPLTSEPIYYPVVMENS 1161
Query: 384 PQGSFVGVVSATDPDNRKSP-IRYSITRSK-----VFNINDNGTITTSNSLDREISAWYN 437
P+ V + A DPD+ + + Y IT NI TTS LDRE A +
Sbjct: 1162 PKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHF 1221
Query: 438 LSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCE--NAGSGQVIQTISAV 494
L +T T+ + S+I + VQVL+ ND+ P+F + Y+ + E G+ I A
Sbjct: 1222 LEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAF 1281
Query: 495 DRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIAD 554
DRDE Y S+ D N+ ID + ++++R F + ++I D
Sbjct: 1282 DRDEGPNAEISY---SIVDGNDDGKFFIDPKTG---MVSSRKQFTAGSYDI--LTIKAVD 1333
Query: 555 NGIPSLTSTNTLTI 568
NG P +ST L I
Sbjct: 1334 NGRPQKSSTARLHI 1347
Score = 158 bits (400), Expect = 2e-38
Identities = 150/538 (27%), Positives = 247/538 (45%), Gaps = 57/538 (10%)
Query: 74 NNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESE 133
N + ++G S F ++ G I + LD E+RS+Y + +V D T AV ++
Sbjct: 1390 NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNVAV---TQ 1445
Query: 134 FVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQG 193
IKV D NDN P+F Y+ + E T ++Q+ A+D D+ +L Y++
Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH-----KLSYTVHSS 1500
Query: 194 -----QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSD 248
F ++P+TGV+ + ++D E QD++ + I +D + V++ + D
Sbjct: 1501 IDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ--EFPYRRNLARVIVNVED 1558
Query: 249 VNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITN 308
ND+ P F LY +V ESA G+++ + A D D GENAE+ Y+IE ++ I
Sbjct: 1559 ANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKI-- 1616
Query: 309 HETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEP- 367
E GI+ + K+ D + + KV + P ++T ++I V D
Sbjct: 1617 -EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPM-------SATAIVRISVTMSDNSH 1668
Query: 368 PLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITR---SKVFNIND-NGTIT 423
P F+ Y EV E G+ V ++SA +S + Y + + +F IN +G IT
Sbjct: 1669 PKFIHKDYQAEVNENVDIGTSVILISAIS----QSTLIYEVKDGDINGIFTINPYSGVIT 1724
Query: 424 TSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENA 482
T +LD E ++ Y L I AT + S+ + +Q+++ ND+AP F Y + E A
Sbjct: 1725 TQKALDYERTSSYQLIIQATNMAGM--ASNATVNIQIVDENDNAPVFLFSQYSGSLSEAA 1782
Query: 483 GSGQVIQT-------ISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNR 535
++++ I A D D + Y VE T FT+ +T I R
Sbjct: 1783 PINSIVRSLDNSPLVIRATDADSNRNALLVY--QIVESTAKKFFTV---DSSTGAI---R 1834
Query: 536 TGFNLQEEPV--FYISILIADNGIPSLTSTN--TLTIHVCDCGDSGSTQTCQYQELVL 589
T NL E + F+ + + D+G P LT+ + + I V D D+ T E +L
Sbjct: 1835 TIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETIL 1892
Score = 155 bits (393), Expect = 1e-37
Identities = 143/504 (28%), Positives = 231/504 (45%), Gaps = 38/504 (7%)
Query: 87 GSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEP 146
G F+I++ TG I ++LDRE + + + + IKV D+NDN+P
Sbjct: 2753 GGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKP 2812
Query: 147 KFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSL-LQGQP-----YFSVE 200
F Y+ I+ E P GT + QV A D D G N ++ YSL QP F+++
Sbjct: 2813 VFETSSYDTIIMEGMPVGTKLTQVRAIDMD---WGANGQVTYSLHSDSQPEKVMEAFNID 2869
Query: 201 PTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESL 260
TG I +D E + + A D +G+ +LS T V ++++D+NDN P+F + +
Sbjct: 2870 SNTGWISTLKDLDHETDPTFTFSVVASD-LGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
Query: 261 YRLTVSESAPTGTSIGTIMAYDNDIGE-NAEMDYSIEEDDSQTFDIITNHETQEGIVILK 319
YR V ES P G + + +D D + N ++ Y I + + E V +K
Sbjct: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG-RFALGLVQSEWKVYVK 2987
Query: 320 KKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFE 378
+ +D E Q+ Y + + Q M +++ V DV D P+ Y
Sbjct: 2988 RPLDREEQDIYFLNITATDGLFVTQAM----------VEVSVSDVNDNSPVCDQVAYTAL 3037
Query: 379 VFEETPQGSFVGVVSATDPD-NRKSPIRYSI---TRSKVFNINDNGTITTSNSLDREISA 434
+ E+ P + VSA D D IRYS+ S+ F ++G + T LDRE
Sbjct: 3038 LPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIP 3097
Query: 435 WYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTISA 493
Y+L AT+ S+I L ++ ++ND+ P F S +Y T V EN + ++ + A
Sbjct: 3098 VYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQA 3155
Query: 494 VDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIA 553
VD D I Y S+ D+ F+I D+++ I+ + +++ + IS+
Sbjct: 3156 VDPDIGINRKVVY---SLADSAGGVFSI----DSSSGIIILEQPLDREQQSSYNISVRAT 3208
Query: 554 DNGI-PSLTSTNTLTIHVCDCGDS 576
D SL+S T+TI V D D+
Sbjct: 3209 DQSPGQSLSSLTTVTITVLDINDN 3232
Score = 150 bits (379), Expect = 4e-36
Identities = 136/502 (27%), Positives = 220/502 (43%), Gaps = 45/502 (8%)
Query: 90 FIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFL 149
F ID TG I ++ LD E + D+ ++ + ++V+DINDN P F
Sbjct: 2866 FNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFA 2925
Query: 150 DEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP----YFSVEPTTGV 205
E Y V E P G +V ++ D D +S N ++ Y + G P + +
Sbjct: 2926 QEVYRGNVKESDPPGEVVAVLSTWDRD--TSDVNRQVSYHITGGNPRGRFALGLVQSEWK 2983
Query: 206 IRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTV 265
+ + +DRE QD Y++ I A D G V + +SDVNDN P+ + Y +
Sbjct: 2984 VYVKRPLDREEQDIYFLNITATD-----GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALL 3038
Query: 266 SESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFE 325
E P+ I + A D DIG N + YS+ + F + + + G + +D E
Sbjct: 3039 PEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFL----DPESGELKTLALLDRE 3094
Query: 326 HQNHYGIRAKVKNHHVPEQLMKYHTEASTTF----IKIQVEDV-DEPPLFLLPYYVFEVF 380
Y + AK T+ F I + +EDV D PP+F +Y V+
Sbjct: 3095 RIPVYSLMAKA-------------TDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVY 3141
Query: 381 EETPQGSFVGVVSATDPD---NRKSPIRYSITRSKVFNI-NDNGTITTSNSLDREISAWY 436
E T + + V A DPD NRK + + VF+I + +G I LDRE + Y
Sbjct: 3142 ENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSY 3201
Query: 437 NLSITATEKYNIEQISSI-PLYVQVLNINDHAPEFSQY-YETYVCENAGSGQVIQTISAV 494
N+S+ AT++ + +SS+ + + VL+IND+ P F + Y V E+ G + + A
Sbjct: 3202 NISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFAT 3261
Query: 495 DRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIAD 554
+D Y L F I N + ++ + L + FY+ + D
Sbjct: 3262 SKDIGTNAEITY--LIRSGNEQGKFKI--NPKTGGISVSEVLDYELCKR--FYLVVEAKD 3315
Query: 555 NGIPSLTSTNTLTIHVCDCGDS 576
G P+L++ T+ I++ D D+
Sbjct: 3316 GGTPALSAVATVNINLTDVNDN 3337
Score = 150 bits (378), Expect = 6e-36
Identities = 142/502 (28%), Positives = 220/502 (43%), Gaps = 33/502 (6%)
Query: 79 YKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKV 138
Y ++ F ID TG + + LD E S Y L + D TG E + + V
Sbjct: 2220 YIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLL--V 2277
Query: 139 SDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQ----GQ 194
+D+NDN P F Y + E S GT V+QV + DAD S NN + Y ++Q
Sbjct: 2278 NDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDAD---SENNKMVHYQIVQDTYNST 2334
Query: 195 PYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKP 254
YF ++ ++G+I + +D EL + +++ D G P +LS V I +SDVNDN P
Sbjct: 2335 DYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDS-GFP-SLSSEVLVHIYISDVNDNPP 2392
Query: 255 IFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEG 314
+F + +Y VSE AP G + + A D D + ++YSI + +T ++ +++ G
Sbjct: 2393 VFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLM---DSKSG 2449
Query: 315 IVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVD-EPPLFLLP 373
++ L + Y + V + ST + I+V + P F
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSD----------GLFTSTAQVHIRVLGANLYSPAFSQS 2499
Query: 374 YYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITRSKV---FNINDNGTITTSNSLD 429
YV EV E G+ V V ATD D I Y+I F I+ NG + T+ LD
Sbjct: 2500 TYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLD 2559
Query: 430 REISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVI 488
RE ++SI + + + V V++ ND+AP+F + Y V + G G ++
Sbjct: 2560 RENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLV 2619
Query: 489 QTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYI 548
+ A+D D+ Y S + + ID + V N FN + V
Sbjct: 2620 TQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGN---FNQLKNTVLSF 2676
Query: 549 SILIADNGIPSLTSTNTLTIHV 570
+ D GIP S + IHV
Sbjct: 2677 FVKAVDGGIPVKHSLIPVYIHV 2698
Score = 142 bits (358), Expect = 1e-33
Identities = 126/462 (27%), Positives = 222/462 (48%), Gaps = 33/462 (7%)
Query: 152 PYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQG--QPYFSVEPTTGVIRIS 209
P + V E P G ++++ A DAD SG N ++L+++ G F+++ TG +++
Sbjct: 730 PSDVAVKEDLPVGANILKIKAYDAD---SGFNGKVLFTISDGNTDSCFNIDMETGQLKVL 786
Query: 210 SKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESA 269
MDRE D Y + I D +G P S + I + D NDN P+F + Y + + ES+
Sbjct: 787 MPMDREHTDLYLLNITIYD-LGNP-QKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844
Query: 270 PTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNH 329
GT I + A D D+G N E+ YS+ D+Q F I + GIV + ++D E + +
Sbjct: 845 GIGTEIIQVEARDKDLGSNGEVTYSV-LTDTQQFAI----NSSTGIVYVADQLDRESKAN 899
Query: 330 YGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDE-PPLFLLPYYVFEVFEETPQGSF 388
Y ++ + ++ Q + S +K+ ++DV++ P F+ Y +V E+ P G+
Sbjct: 900 YSLKIEARDKAESGQQL-----FSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTV 954
Query: 389 VGVVSATDPD-NRKSPIRYSITR--SKVFNIND-NGTITTSNSLDREISAWYNLSITATE 444
+ + DPD +RYS+ + F I+ +G I S LD E +YNL++ A +
Sbjct: 955 IAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD 1014
Query: 445 KYNIEQISSIP-LYVQVLNIND--HAPEFSQYYET-YVCENAGSGQVIQTISAVDRDESI 500
K +SS+ + V+V+++N+ H P F + V EN+ G + ++A D D
Sbjct: 1015 KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGR 1074
Query: 501 EEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSL 560
+ Y S+ D + ID++ ++T + + +++++ D G+ L
Sbjct: 1075 DGEIQY---SIRDGSGLGRFSIDDESG---VITAADILDRETMGSYWLTVYATDRGVVPL 1128
Query: 561 TSTNTLTIHVCDCGDSGS-TQTCQYQELVLSMGFKTEVIIAI 601
ST + I V D D+ T Y +V+ K +I I
Sbjct: 1129 YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Score = 132 bits (332), Expect = 1e-30
Identities = 138/536 (25%), Positives = 246/536 (45%), Gaps = 64/536 (11%)
Query: 55 EMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQ-KLDREERSLY 113
E NT + + + + N +Y +L G + F I +G I DREE+ LY
Sbjct: 1993 ENNTNITKVAIVNAVGNRLNEPLKYSILNPG--NKFKIKSTSGVIQTTGVPFDREEQELY 2050
Query: 114 ILRAQVIDIATGRAVEPESEFVIKVS--DINDNEPKFLDEPYEAIVPEMSPEGTLVIQVT 171
L V++ + + V++V+ DINDN P F+ PY A V + GTL+ QVT
Sbjct: 2051 EL---VVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
Query: 172 ASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQD-EYWVIIQAKDMI 230
A D D G N + Y L +F + P +G + + + +L + EY V I AKD
Sbjct: 2108 AIDKD---KGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDG- 2163
Query: 231 GQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAE 290
G+P S +TSV + ++ VN P+F + Y +V+E T I +I A + G+
Sbjct: 2164 GKP---SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-GQGI- 2218
Query: 291 MDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHT 350
+ I+ D + F+I + G++ + +D+E + Y + + + L
Sbjct: 2219 IYIIIDGDPFKQFNI----DFDTGVLKVVSPLDYEVTSAYKLTIRAS-----DALTGARA 2269
Query: 351 EASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSP-IRYSI 408
E + + + V DV D PP+F P Y + E + G+ V V + D D+ + + Y I
Sbjct: 2270 EVT---VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQI 2326
Query: 409 TR-----SKVFNI-NDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLN 462
+ + F+I + +G I T+ LD E+ L + + + S + +++ + +
Sbjct: 2327 VQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISD 2386
Query: 463 INDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTI 521
+ND+ P F+Q YE+YV E A G + + A D D S D + ++I
Sbjct: 2387 VNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSS-------------DFDRLEYSI 2433
Query: 522 IDNQDNTAVILTNRTGF-------NLQEEPVFYISILIADNGIPSLTSTNTLTIHV 570
+ D T+ ++ +++G + EP++ +++ ++D T+T +H+
Sbjct: 2434 LSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG-----LFTSTAQVHI 2484
Score = 130 bits (326), Expect = 6e-30
Identities = 129/503 (25%), Positives = 221/503 (43%), Gaps = 38/503 (7%)
Query: 79 YKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKV 138
Y++ F I+ +G I + LD E S Y L Q ++A + + I++
Sbjct: 1703 YEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMA---GMASNATVNIQI 1759
Query: 139 SDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASD----ADDPSSGNNARLLYSLLQG- 193
D NDN P FL Y + E +P ++V + S A D S NA L+Y +++
Sbjct: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVEST 1819
Query: 194 -QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDN 252
+ +F+V+ +TG IR + +D E + + +D V I+++DVNDN
Sbjct: 1820 AKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDN 1879
Query: 253 KPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQ 312
P+F ++++ + G + + A D D E+ YS+ E F I +N
Sbjct: 1880 PPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSN---- 1935
Query: 313 EGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLL 372
G++ +K + ++HY + KV + Y T T +K E +D F
Sbjct: 1936 SGVLTIKN--NNLSKDHYMLIVKVSDGKF------YSTSMVTIMVK---EAMDSGLHFTQ 1984
Query: 373 PYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITR-SKVFNINDNGTI--TTSNSLD 429
+Y + E + V +V+A + P++YSI F I + TT D
Sbjct: 1985 SFYSTSISENNTNITKVAIVNAVG-NRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFD 2043
Query: 430 REISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVI 488
RE Y L + A+ + + +++ + + V + +IND++P F Y V +A G +I
Sbjct: 2044 REEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLI 2103
Query: 489 QTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFY- 547
++A+D+D+ Y V + F I N N VIL + FN + Y
Sbjct: 2104 YQVTAIDKDKGPNGEVTY----VLQDDYGHFEINPNSGN--VIL--KEAFNSDLSNIEYG 2155
Query: 548 ISILIADNGIPSLTSTNTLTIHV 570
++IL D G PSL+++ L I +
Sbjct: 2156 VTILAKDGGKPSLSTSVELPITI 2178
Score = 123 bits (308), Expect = 7e-28
Identities = 137/543 (25%), Positives = 233/543 (42%), Gaps = 53/543 (9%)
Query: 69 DLDNGNNSF-QYKLLGAGAGST--FIIDERTGDIYAIQKLDREERSLYILRAQVIDIATG 125
D D+ NN Y+++ ST F ID +G I + LD E L+ + ID
Sbjct: 2313 DADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFP 2372
Query: 126 RAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNAR 185
++ E I +SD+NDN P F YE+ V E++P G V V ASDAD S + R
Sbjct: 2373 -SLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDAD---SSDFDR 2428
Query: 186 LLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVL 243
L YS+L G + F ++ +GVI +S+ + ++ Y + + D G + T V
Sbjct: 2429 LEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD-----GLFTSTAQVH 2483
Query: 244 IKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTF 303
I++ N P F +S Y V E+ GT + + A D D G ++ Y+I D ++
Sbjct: 2484 IRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDR 2543
Query: 304 DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED 363
+I ++ G VI +++D E+ + V+ TTF ++V
Sbjct: 2544 FLIDSN----GQVITTERLDRENPLEGDVSIFVR---------ALDGGGRTTFCTVRVIV 2590
Query: 364 VDE---PPLFLLPYYVFEVFEETPQGSFVGVVSATDPDN-RKSPIRYSITRSKVFNIND- 418
VDE P F+ Y V + +G V V A DPD+ S I YS+ ++ D
Sbjct: 2591 VDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADL 2650
Query: 419 ------NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ 472
NG + T + ++ + + + A + + S IP+Y+ VL P F+Q
Sbjct: 2651 LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
Query: 473 -YYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVI 531
Y + E+ G + T+ + ++ ++ ++ E N+ I + T I
Sbjct: 2711 SQYSFTIAEDTAIGSTVDTLRILP-----SQNVWFSTVNGERPENNKGGIFVIEQETGTI 2765
Query: 532 LTNRTGFNLQEEPVFYISILIADNGIP----SLTSTNTLTIHVCDCGDSGST-QTCQYQE 586
++ + + P F+ + IP + T + I V D D+ +T Y
Sbjct: 2766 KLDKR-LDRETSPAFHFKVAAT---IPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDT 2821
Query: 587 LVL 589
+++
Sbjct: 2822 IIM 2824
Score = 120 bits (301), Expect = 5e-27
Identities = 136/505 (26%), Positives = 236/505 (46%), Gaps = 52/505 (10%)
Query: 85 GAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDN 144
G+ F+ID +G + K + + Y+L ++ ++ G+ S I V + D+
Sbjct: 1925 GSLDHFLIDSNSGVLTI--KNNNLSKDHYML---IVKVSDGKFYST-SMVTIMVKEAMDS 1978
Query: 145 EPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGN--NARLLYSLLQGQPYFSVEPT 202
F Y + E + T V V A GN N L YS+L F ++ T
Sbjct: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAV-------GNRLNEPLKYSILNPGNKFKIKST 2031
Query: 203 TGVIRISS-KMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLY 261
+GVI+ + DRE Q+ Y ++++A + V + + D+NDN P+F Y
Sbjct: 2032 SGVIQTTGVPFDREEQELYELVVEASRELDHLRV--ARVVVRVNIEDINDNSPVFVGLPY 2089
Query: 262 RLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKK 321
V A GT I + A D D G N E+ Y ++ DD F+I N G VILK+
Sbjct: 2090 YAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ-DDYGHFEINPN----SGNVILKEA 2144
Query: 322 VDFEHQN-HYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEP-PLFLLPYYVFEV 379
+ + N YG+ K+ P + +T +++ + V++ P+F P+Y V
Sbjct: 2145 FNSDLSNIEYGVTILAKDGGKP---------SLSTSVELPITIVNKAMPVFDKPFYTASV 2195
Query: 380 FEETPQGSFVGVVSATDPDNRKSPIRYSITRS---KVFNIN-DNGTITTSNSLDREISAW 435
E+ + + ++AT P+ + I Y I K FNI+ D G + + LD E+++
Sbjct: 2196 NEDIRMNTPILSINATSPEGQG--IIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSA 2253
Query: 436 YNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAV 494
Y L+I A++ + + + + + V ++ND+ P F Q Y T + E + G + + ++
Sbjct: 2254 YKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSI 2312
Query: 495 DRDESIEEHHFYFNLSVEDTNNSS-FTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIA 553
D D E + V+DT NS+ + ID+ ++ +ILT R L E V + ++ +
Sbjct: 2313 DADS--ENNKMVHYQIVQDTYNSTDYFHIDS--SSGLILTARM---LDHELVQHCTLKVR 2365
Query: 554 --DNGIPSLTSTNTLTIHVCDCGDS 576
D+G PSL+S + I++ D D+
Sbjct: 2366 SIDSGFPSLSSEVLVHIYISDVNDN 2390
Score = 107 bits (268), Expect = 3e-23
Identities = 123/468 (26%), Positives = 200/468 (42%), Gaps = 43/468 (9%)
Query: 105 LDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEG 164
L+RE + Y+L + G +E ++ I+V D+ND P F Y + E +P
Sbjct: 117 LNREIQDNYLLIVK--GSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLR 174
Query: 165 TLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVII 224
T V QVTA+DAD G+N Y FSV PT+GVI +S +++ + ++ Y + I
Sbjct: 175 TSVAQVTATDAD---IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEI 231
Query: 225 QAKD----MIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMA 280
A D + G G +S T + + + +N++ P + E PT +
Sbjct: 232 LAVDRGMKLYGNNG-VSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPT---YAVVTV 287
Query: 281 YDNDIGENAEMD-YSIEEDD--SQTFDIITNHETQEGIVILKKKVDFEHQNH-YGIRAKV 336
D D G N E++ SI D Q F E + +K++D+E + Y + +
Sbjct: 288 DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQA 347
Query: 337 KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSAT- 395
K+ P++ + +I D P F Y + E +P G V +V +
Sbjct: 348 KDKGSPQKC----SALKAVYIGNPTRDT-VPIRFEKEVYDVSISEFSPPGVVVAIVKLSP 402
Query: 396 ---DPDNRKSPIRYSITRSKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
D + + SP ++ F IN +G I T+ L+ Y L +T E Q+
Sbjct: 403 EPIDVEYKLSPGEDAV----YFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQV 458
Query: 452 SSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLS 510
+ + + + NDH PEF Q Y+ YV E+ G + T+SA D+D+ + Y S
Sbjct: 459 T-----ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKG---ENGYITYS 510
Query: 511 VEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIP 558
+ N F I NQ + T F E ++ + +D G P
Sbjct: 511 IASLNLLPFVI--NQFTGVISTTEELDFESSPE-IYRFIVRASDWGSP 555
Score = 105 bits (262), Expect = 2e-22
Identities = 133/563 (23%), Positives = 235/563 (41%), Gaps = 76/563 (13%)
Query: 68 SDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREER-SLYILRAQVIDIATGR 126
SD D G N + + + F+I++ TG I ++LD E +Y + D +
Sbjct: 497 SDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPY 556
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
E E I++ ++NDN P F + ++ P G + V+A D D+ +
Sbjct: 557 RHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELEL-----V 611
Query: 187 LYSLLQGQP--YFSVEPTTGVIRISSKMDRE--LQDEYWVIIQAKDMIGQPGALSGTTSV 242
Y ++ G +F + P +GV+++ + + + I A D +S SV
Sbjct: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Query: 243 L---------------------------------IKLSD-------VNDNKPIFKESLYR 262
L + L D +N P F +S
Sbjct: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
Query: 263 -LTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKK 321
+ V E P G +I I AYD D G N ++ ++I + ++ D N + + G + +
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNT---DSCFNIDMETGQLKVLMP 788
Query: 322 VDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVF 380
+D EH + Y + + + P+ ++S + I VED D P+F+ Y +
Sbjct: 789 MDREHTDLYLLNITIYDLGNPQ-------KSSWRLLTINVEDANDNSPVFIQDSYSVNIL 841
Query: 381 EETPQGSFVGVVSATDPD-NRKSPIRYSI-TRSKVFNINDN-GTITTSNSLDREISAWYN 437
E + G+ + V A D D + YS+ T ++ F IN + G + ++ LDRE A Y+
Sbjct: 842 ESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYS 901
Query: 438 LSITATEKYNIEQ--ISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTISAV 494
L I A +K Q S + L V + ++ND +P F Y V E+ G VI +
Sbjct: 902 LKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETH 961
Query: 495 DRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIAD 554
D D + Y S+ + N F I ++ + A+ L+ + Q+ + +++ D
Sbjct: 962 DPDLGLGGQVRY---SLVNDYNGRFEI--DKASGAIRLSKELDYEKQQ--FYNLTVRAKD 1014
Query: 555 NGIP-SLTSTNTLTIHVCDCGDS 576
G P SL+S + + + V D ++
Sbjct: 1015 KGRPVSLSSVSFVEVEVVDVNEN 1037
Score = 102 bits (254), Expect = 1e-21
Identities = 124/464 (26%), Positives = 204/464 (43%), Gaps = 56/464 (12%)
Query: 78 QYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIK 137
+YKL F I+ R+G I + L+ ++ +Y L T + + +++ I
Sbjct: 408 EYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEV------TNKEGDLKAQVTIS 461
Query: 138 VSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSL--LQGQP 195
+ D ND+ P+F Y+A V E P GT V+ V+ASD D G N + YS+ L P
Sbjct: 462 IEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKD---KGENGYITYSIASLNLLP 518
Query: 196 YFSVEPTTGVIRISSKMDRELQDE-YWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKP 254
F + TGVI + ++D E E Y I++A D G P +V I++ +VNDN P
Sbjct: 519 -FVINQFTGVISTTEELDFESSPEIYRFIVRASDW-GSPYRHESEVNVTIRIGNVNDNSP 576
Query: 255 IFKESLYRLTVSESAPTGTSIGTIMAYDND--------IGENAEMDYSIEEDDSQTFDI- 305
+F++ + +S P G I + A D D I E+ + DS +
Sbjct: 577 LFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLK 636
Query: 306 --ITNHETQEGIVILK-------KKVDFEHQNHYGIRAKV-------KNHHVPEQLMKYH 349
+TN + G L+ D N + KV + V ++L +
Sbjct: 637 KSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696
Query: 350 TEASTTFIKIQVED--VD------EPPLF--LLPYYVFEVFEETPQGSFVGVVSATDPDN 399
+ K+ +ED +D + P F P V V E+ P G+ + + A D D+
Sbjct: 697 LIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDV-AVKEDLPVGANILKIKAYDADS 755
Query: 400 R-KSPIRYSIT---RSKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSI 454
+ ++I+ FNI+ + G + +DRE + Y L+IT + N ++ S
Sbjct: 756 GFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWR 815
Query: 455 PLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRD 497
L + V + ND++P F Q Y + E++G G I + A D+D
Sbjct: 816 LLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
Score = 92.8 bits (229), Expect = 1e-18
Identities = 125/508 (24%), Positives = 205/508 (40%), Gaps = 87/508 (17%)
Query: 147 KFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP--YFSVEPTTG 204
+F E Y+ + E SP G +V V S +P + Y L G+ YF + P +G
Sbjct: 375 RFEKEVYDVSISEFSPPGVVVAIVKLSP--EPID-----VEYKLSPGEDAVYFKINPRSG 427
Query: 205 VIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLT 264
+I + ++ ++ Y + + K+ G L V I + D ND+ P F++ LY
Sbjct: 428 LIVTARPLNTVKKEVYKLEVTNKE-----GDLKA--QVTISIEDANDHTPEFQQPLYDAY 480
Query: 265 VSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDF 324
V+ES P GTS+ T+ A D D GEN + YSI + F + N T G++ +++DF
Sbjct: 481 VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPF--VINQFT--GVISTTEELDF 536
Query: 325 EHQNH-YGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEE 382
E Y + + P ++ +E + T I++ +V D PLF + +
Sbjct: 537 ESSPEIYRFIVRASDWGSP---YRHESEVNVT---IRIGNVNDNSPLFEKVACQGVISYD 590
Query: 383 TPQGSFVGVVSATDPDNRKSPIRYSITRSK---VFNIN-DNGTITTSNSLDRE--ISAWY 436
P G + VSA D D + ++Y I F +N D+G + SL + +
Sbjct: 591 FPVGGHITAVSAIDIDELEL-VKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNF 649
Query: 437 NLSITATEKYNIEQISSIPL---------------------------------------- 456
L ITAT+ N+ SI +
Sbjct: 650 ALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLE 709
Query: 457 --YVQVLNINDHAPEFSQYY--ETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVE 512
++ +IN P F + + + V E+ G I I A D D + ++
Sbjct: 710 DGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLF---TIS 766
Query: 513 DTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCD 572
D N S ID + +L + + ++ ++I I D G P +S LTI+V D
Sbjct: 767 DGNTDSCFNIDMETGQLKVL---MPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVED 823
Query: 573 CGDSGST--QTCQYQELVLSMGFKTEVI 598
D+ Q ++ S G TE+I
Sbjct: 824 ANDNSPVFIQDSYSVNILESSGIGTEII 851
Score = 73.6 bits (179), Expect = 7e-13
Identities = 52/193 (26%), Positives = 101/193 (52%), Gaps = 13/193 (6%)
Query: 209 SSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSES 268
S+ ++RE+QD Y +I++ + G+ L T V I++ D+ND +P+F + Y +T++ES
Sbjct: 114 SAILNREIQDNYLLIVKGS-VRGED--LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAES 170
Query: 269 APTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQN 328
P TS+ + A D DIG N E Y + D+ + H T G++ L +++++ +N
Sbjct: 171 TPLRTSVAQVTATDADIGSNGEFYYYFK----NKVDLFSVHPT-SGVISLSGRLNYDEKN 225
Query: 329 HYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDE--PPLFLLPYYVFEVFEETPQG 386
Y + + + +L + +ST + + +E ++E P + ++ + F + E+ P
Sbjct: 226 RYDLEILAVDRGM--KLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL-EKEPTY 282
Query: 387 SFVGVVSATDPDN 399
+ V V D N
Sbjct: 283 AVVTVDDLDDGAN 295
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 190 bits (483), Expect = 4e-48
Identities = 182/651 (27%), Positives = 302/651 (46%), Gaps = 54/651 (8%)
Query: 26 SQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGA 84
S+T+ ++ V R KR W + E + + Q+ SD F Y + G
Sbjct: 120 SKTRHTRETVLR--RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVF-YSISGR 176
Query: 85 GAG----STFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSD 140
G + F I+ TG+++ + +DREE ++ L A A G + + I+V D
Sbjct: 177 GVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVED 235
Query: 141 INDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP----Y 196
NDN P F + Y V E S GT V V A+D D+P + + RL YS+LQ P
Sbjct: 236 ENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGL 294
Query: 197 FSVEPTTGVIR-ISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPI 255
FSV P+TGVI +S +DRE+ D+Y +I++ +DM GQ L GT++ +I ++D NDN P
Sbjct: 295 FSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPT 354
Query: 256 FKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYS---IEEDDSQTFDIITNHETQ 312
F+++ Y V E+A I I D D+ A + ++ +++ F I T+ ET
Sbjct: 355 FRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETN 413
Query: 313 EGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLL 372
EG++ + K +++E + V N + + T + + + V D+DE P
Sbjct: 414 EGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTP 473
Query: 373 PYYVFEVFEETPQGSFVGVVSATDPDNRK-SPIRYS--------ITRSKVFNINDNGTIT 423
+ E GS + A DP+NR + +RY IT ++ +G+I
Sbjct: 474 AAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEI-----SGSII 528
Query: 424 TSNSLDREI----SAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVC 479
TS LDRE+ + YN+++ A +K ++ + L V + ++ND+ PE Q Y
Sbjct: 529 TSKILDREVETPKNELYNITVLAIDK--DDRSCTGTLAVNIEDVNDNPPEILQEYVVICK 586
Query: 480 ENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFN 539
G ++ AVD DE + FYF+L S + ++TA L+ +
Sbjct: 587 PKMGYTDIL----AVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAG 642
Query: 540 LQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVII 599
QE + I I + D +T L +++C+C + TQ C+ + I+
Sbjct: 643 FQE---YTIPITVKDRA--GQAATKLLRVNLCEC--THPTQ-CRATSRSTGVILGKWAIL 694
Query: 600 AILICIMIIFGFIF-LTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEE 649
AIL+ I ++F + L G+ K FPE + ++N+ + E G++
Sbjct: 695 AILLGIALLFSVLLTLVCGVFGATKGKRFPE--DLAQQNLIISNTEAPGDD 743
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 190 bits (483), Expect = 4e-48
Identities = 182/651 (27%), Positives = 302/651 (46%), Gaps = 54/651 (8%)
Query: 26 SQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGA 84
S+T+ ++ V R KR W + E + + Q+ SD F Y + G
Sbjct: 120 SKTRHTRETVLR--RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVF-YSISGR 176
Query: 85 GAG----STFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSD 140
G + F I+ TG+++ + +DREE ++ L A A G + + I+V D
Sbjct: 177 GVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVED 235
Query: 141 INDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP----Y 196
NDN P F + Y V E S GT V V A+D D+P + + RL YS+LQ P
Sbjct: 236 ENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGL 294
Query: 197 FSVEPTTGVIR-ISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPI 255
FSV P+TGVI +S +DRE+ D+Y +I++ +DM GQ L GT++ +I ++D NDN P
Sbjct: 295 FSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPT 354
Query: 256 FKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYS---IEEDDSQTFDIITNHETQ 312
F+++ Y V E+A I I D D+ A + ++ +++ F I T+ ET
Sbjct: 355 FRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETN 413
Query: 313 EGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLL 372
EG++ + K +++E + V N + + T + + + V D+DE P
Sbjct: 414 EGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTP 473
Query: 373 PYYVFEVFEETPQGSFVGVVSATDPDNRK-SPIRYS--------ITRSKVFNINDNGTIT 423
+ E GS + A DP+NR + +RY IT ++ +G+I
Sbjct: 474 AAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEI-----SGSII 528
Query: 424 TSNSLDREI----SAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVC 479
TS LDRE+ + YN+++ A +K ++ + L V + ++ND+ PE Q Y
Sbjct: 529 TSKILDREVETPKNELYNITVLAIDK--DDRSCTGTLAVNIEDVNDNPPEILQEYVVICK 586
Query: 480 ENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFN 539
G ++ AVD DE + FYF+L S + ++TA L+ +
Sbjct: 587 PKMGYTDIL----AVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAG 642
Query: 540 LQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVII 599
QE + I I + D +T L +++C+C + TQ C+ + I+
Sbjct: 643 FQE---YTIPITVKDRA--GQAATKLLRVNLCEC--THPTQ-CRATSRSTGVILGKWAIL 694
Query: 600 AILICIMIIFGFIF-LTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEE 649
AIL+ I ++F + L G+ K FPE + ++N+ + E G++
Sbjct: 695 AILLGIALLFSVLLTLVCGVFGATKGKRFPE--DLAQQNLIISNTEAPGDD 743
Score = 37.7 bits (86), Expect = 0.041
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 3/62 (4%)
Query: 701 EKLEEAN-TDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKR 759
EKL N + P D + TY +EG GS AGS+ +++ D+LN L P+F
Sbjct: 831 EKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSE--KQEEDGLDFLNNLEPKFIT 888
Query: 760 LA 761
LA
Sbjct: 889 LA 890
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 188 bits (477), Expect = 2e-47
Identities = 171/567 (30%), Positives = 278/567 (49%), Gaps = 46/567 (8%)
Query: 40 RVKRGWVWNQFFVPEEMNTT-SHHIGQLRSDLDNGNNSFQYKLLGAGAGST----FIIDE 94
R KR V + +PE +G++ D D S +++L G G F I+E
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERS-KFRLTGKGVDQEPKGIFRINE 192
Query: 95 RTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYE 154
TG + + LDRE ++Y L + D+ G+ +E + V D NDN P F + PY
Sbjct: 193 NTGSVSVTRTLDREVIAVYQLFVETTDV-NGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 155 AIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP------YFSVEPTTG-VIR 207
V E SP GT V+++TA DADDP++ +NA L Y++ Q P F ++P G ++
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPAT-DNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVT 310
Query: 208 ISSK--MDRELQD--EYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRL 263
+ S +DRE + +Y +II+A+DM G L+GT + I + D ND+ P F + ++
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQA 370
Query: 264 TVSESAPTGTSIGTIMAYDNDIGENA-EMDYS-IEEDDSQTFDIITNHETQEGIVILKKK 321
TV E A G + + +D A Y+ I + Q+F+I TN +T EG++ + K
Sbjct: 371 TVEEGA-VGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKP 429
Query: 322 VDFEHQNHYGIRAKVKNHH--VPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEV 379
+D+E + + KV+N VP+ + +ST + I V DV+E P+F +
Sbjct: 430 LDYEISAFHTLLIKVENEDPLVPD---VSYGPSSTATVHITVLDVNEGPVFYPDPMMVTR 486
Query: 380 FEETPQGSFVGVVSATDPDN-RKSPIRYSITRSKV--FNIND-NGTITTSNSLDREI--- 432
E+ GS + V+ATDPD+ + IRYS+ + NIN NGT+ T+ LDRE
Sbjct: 487 QEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFV 546
Query: 433 -SAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTI 491
++ Y A + N + L + + ++ND+AP F VC++A + V+ +
Sbjct: 547 DNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAP-FIYPTVAEVCDDAKNLSVV-IL 604
Query: 492 SAVDRDESIEEHHFYFNLSVEDTNNSSFTI--IDNQDNTAVILTNRTGFNLQEEPVFYIS 549
A D+D F F + + + + I I+N +L N N + +
Sbjct: 605 GASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKAN------YNLP 658
Query: 550 ILIADNGIPSLTSTNTLTIHVCDCGDS 576
I++ D+G P +T+ L + VC C +S
Sbjct: 659 IMVTDSGKPPMTNITDLRVQVCSCRNS 685
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 186 bits (473), Expect = 5e-47
Identities = 189/676 (27%), Positives = 303/676 (44%), Gaps = 58/676 (8%)
Query: 20 LGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQ 78
L A EN KK + R KR W + E + H+ Q++SD F
Sbjct: 111 LSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIF- 169
Query: 79 YKLLGAGAG----STFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEF 134
Y + G G + F I++ TGDI+ + +DRE+ + L A G A E
Sbjct: 170 YSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATT-ADGYAPEYPLPL 228
Query: 135 VIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQ 194
+IK+ D NDN P F VPE GT V +VTA+D D+P + + RL Y +LQ
Sbjct: 229 IIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKILQQI 287
Query: 195 P----YFSVEPTTGVIRISSK-MDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDV 249
P +FS+ P TGVI ++ +DRE D Y +I++ +DM GQP L T ++ I L D
Sbjct: 288 PDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDE 347
Query: 250 NDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGE--NAEMDYSI-EEDDSQTFDII 306
NDN P F E+ Y V E+ I + D D+ +++ Y I + +++ F I
Sbjct: 348 NDNPPSFTETSYVTEVEENR-IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIIS 406
Query: 307 TNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEA-STTFIKIQVEDVD 365
T+ T EG++ + K +++E ++ V N + T TT + +++ D D
Sbjct: 407 TDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSD 466
Query: 366 EPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSI--TRSKVFNINDN-GT 421
E P P V + + P G + A DP+ + +RY F IN + G
Sbjct: 467 EGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGD 526
Query: 422 ITTSNSLDREI----SAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETY 477
+ T LDRE + YN+S+ A + + + + L V + + NDHAP+ + E
Sbjct: 527 LRTLKVLDRESKFVKNNQYNISVVAVDA--VGRSCTGTLVVHLDDYNDHAPQIDK--EVT 582
Query: 478 VCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTG 537
+C+N + + VD D F F L D + S I+ +D IL R
Sbjct: 583 ICQN---NEDFAVLKPVDPDGPENGPPFQFFL---DNSASKNWNIEEKDGKTAILRQRQN 636
Query: 538 FNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQE---------LV 588
+ Y S+ I L +T+ LT+ VCDC + C+ ++ ++
Sbjct: 637 LDYN-----YYSVPIQIKDRHGLVATHMLTVRVCDC---STPSECRMKDKSTRDVRPNVI 688
Query: 589 LSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGE 648
L +++ ++ + I+F +T +R + FPE + ++N+ + EG GE
Sbjct: 689 LGRWAILAMVLGSVLLLCILFTCFCVT---AKRTVKKCFPE--DIAQQNLIVSNTEGPGE 743
Query: 649 EDTEAFDIAELRSSTI 664
E TEA +++S I
Sbjct: 744 EVTEANIRLPMQTSNI 759
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 186 bits (473), Expect = 5e-47
Identities = 189/676 (27%), Positives = 303/676 (44%), Gaps = 58/676 (8%)
Query: 20 LGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQ 78
L A EN KK + R KR W + E + H+ Q++SD F
Sbjct: 111 LSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIF- 169
Query: 79 YKLLGAGAG----STFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEF 134
Y + G G + F I++ TGDI+ + +DRE+ + L A G A E
Sbjct: 170 YSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATT-ADGYAPEYPLPL 228
Query: 135 VIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQ 194
+IK+ D NDN P F VPE GT V +VTA+D D+P + + RL Y +LQ
Sbjct: 229 IIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKILQQI 287
Query: 195 P----YFSVEPTTGVIRISSK-MDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDV 249
P +FS+ P TGVI ++ +DRE D Y +I++ +DM GQP L T ++ I L D
Sbjct: 288 PDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDE 347
Query: 250 NDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGE--NAEMDYSI-EEDDSQTFDII 306
NDN P F E+ Y V E+ I + D D+ +++ Y I + +++ F I
Sbjct: 348 NDNPPSFTETSYVTEVEENR-IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIIS 406
Query: 307 TNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEA-STTFIKIQVEDVD 365
T+ T EG++ + K +++E ++ V N + T TT + +++ D D
Sbjct: 407 TDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSD 466
Query: 366 EPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSI--TRSKVFNINDN-GT 421
E P P V + + P G + A DP+ + +RY F IN + G
Sbjct: 467 EGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGD 526
Query: 422 ITTSNSLDREI----SAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETY 477
+ T LDRE + YN+S+ A + + + + L V + + NDHAP+ + E
Sbjct: 527 LRTLKVLDRESKFVKNNQYNISVVAVDA--VGRSCTGTLVVHLDDYNDHAPQIDK--EVT 582
Query: 478 VCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTG 537
+C+N + + VD D F F L D + S I+ +D IL R
Sbjct: 583 ICQN---NEDFAVLKPVDPDGPENGPPFQFFL---DNSASKNWNIEEKDGKTAILRQRQN 636
Query: 538 FNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQE---------LV 588
+ Y S+ I L +T+ LT+ VCDC + C+ ++ ++
Sbjct: 637 LDYN-----YYSVPIQIKDRHGLVATHMLTVRVCDC---STPSECRMKDKSTRDVRPNVI 688
Query: 589 LSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGE 648
L +++ ++ + I+F +T +R + FPE + ++N+ + EG GE
Sbjct: 689 LGRWAILAMVLGSVLLLCILFTCFCVT---AKRTVKKCFPE--DIAQQNLIVSNTEGPGE 743
Query: 649 EDTEAFDIAELRSSTI 664
E TEA +++S I
Sbjct: 744 EVTEANIRLPMQTSNI 759
Score = 34.7 bits (78), Expect = 0.34
Identities = 17/46 (36%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 716 DSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLA 761
D + +Y +EG GSLAGS+ ++E ++L+ L P+F+ LA
Sbjct: 845 DYVCSYNYEGKGSLAGSVGCCSD--RQEEEGLEFLDHLEPKFRTLA 888
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 186 bits (472), Expect = 7e-47
Identities = 153/532 (28%), Positives = 242/532 (45%), Gaps = 33/532 (6%)
Query: 60 SHHIGQL-----RSDLDNGNNSF-QYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLY 113
SH IG + D D N +Y + F I+ TG + + LD E +
Sbjct: 3101 SHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKH 3160
Query: 114 ILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTAS 173
+ ID A + V D+NDN P FL + Y V E +P GT VI + A+
Sbjct: 3161 EMTISAID-GGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNAT 3219
Query: 174 DADDPSSGNNARLLYSLLQGQP-YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQ 232
DAD SG NA + Y++ F ++P TGVI +D E + Y + ++A ++ +
Sbjct: 3220 DAD---SGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE 3276
Query: 233 PGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMD 292
T + I+L N+ P F LY +SE+AP GT +G + A D D+G + E+
Sbjct: 3277 ERCSFATVN--IQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVH 3334
Query: 293 YSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEA 352
Y I +S+ N +T G + + +D E + ++ KN +
Sbjct: 3335 YLIF-GNSRKKGFQINKKT--GQIYVSGILDREKEERVSLKVLAKNFGSIRG-----ADI 3386
Query: 353 STTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSI---- 408
+ + V D ++PP+F L Y ++ E P G+ V VSA D D+ S R+S
Sbjct: 3387 DEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS 3446
Query: 409 -TRSKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDH 466
+ F+IN G IT + LDRE YNLS+ A + S L V + +IND+
Sbjct: 3447 GNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDN 3506
Query: 467 APEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQD 526
P + E V EN G ++ T+ + D D + F + L S F++
Sbjct: 3507 GPMLT-VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL----- 3560
Query: 527 NTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGS 578
+TA +L+ + ++ FY+S++ D+G+P ++ST T+ I V D D+ S
Sbjct: 3561 STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPS 3612
Score = 182 bits (462), Expect = 1e-45
Identities = 145/503 (28%), Positives = 242/503 (48%), Gaps = 43/503 (8%)
Query: 87 GSTFIIDERTGDIYAIQKLDREERS-LYILRAQVIDIATGRAVEPESEFVIKVSDINDNE 145
G F I TG I LDRE+ + LY++ I+ +T +E I + DINDN
Sbjct: 1678 GRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNP 1737
Query: 146 PKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQG-QPYFSVEPTTG 204
P F + + V E +G+ ++Q+TA DAD+ G NA + Y+++ G F ++P +G
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADE---GANALVTYTIISGADDSFRIDPESG 1794
Query: 205 VIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLT 264
+ + ++DRE + +Y ++++A D G S + I +SDVND+ P F +Y
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADD-----GLQSSDMRINITVSDVNDHTPKFSRPVYSFD 1849
Query: 265 VSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDF 324
+ E G+ + I+A D+D G N E+ Y + EDD D I G+ L + +D+
Sbjct: 1850 IPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDE---DGIFFLNPITGVFNLTRLLDY 1906
Query: 325 EHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEET 383
E Q +Y + + ++ + +T + + DV D PP+F L Y + E
Sbjct: 1907 EVQQYYILTVRAEDG---------GGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENL 1957
Query: 384 PQGSFVGVVSATDPDNR-KSPIRYSITRSK---VFNINDNGTITTSNSLDREISAWYNLS 439
P GS V V + TD D+ S + YSI F ++ NG + +LDRE ++YNL
Sbjct: 1958 PVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLV 2017
Query: 440 ITATEKYNIEQI------SSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISA 493
+ + +++ QI S+ + + +L++ND+ P F TY+ EN V+ A
Sbjct: 2018 V---QVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQA 2074
Query: 494 VDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIA 553
D D + Y L+ N S ID + V LT + +E + ++++
Sbjct: 2075 TDPDSGPNSYIEYTLLNPLG-NKFSIGTIDGE----VRLTGE--LDREEVSNYTLTVVAT 2127
Query: 554 DNGIPSLTSTNTLTIHVCDCGDS 576
D G PSL+S+ + + V D D+
Sbjct: 2128 DKGQPSLSSSTEVVVMVLDINDN 2150
Score = 182 bits (461), Expect = 1e-45
Identities = 163/555 (29%), Positives = 266/555 (47%), Gaps = 54/555 (9%)
Query: 52 VPEEMNTTSHHIGQLRSDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREER 110
VPE+ S + +D D G N+ +Y+L G+ F +D TG I + LD E R
Sbjct: 259 VPEDAVVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEAR 316
Query: 111 SLYILRAQVIDIA----TGRAVEPESEFVIKVSDINDNEP--KFLDEPYE---AIVPEMS 161
Y L Q +D TGRA E +I++ D+NDN+P KF P A V E +
Sbjct: 317 RQYSLTVQAMDRGVPSLTGRA-----EALIQLLDVNDNDPVVKFRYFPATSRYASVDENA 371
Query: 162 PEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVE----PTTGVIRISSKMDRELQ 217
GT+V +T +DAD P++ N + Q +F V+ P +I+++S +DRE
Sbjct: 372 QVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERI 431
Query: 218 DEYWVIIQAKDMIGQPG-----ALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTG 272
Y + + D G P A S S++I ++D+ND+ P+F + +YR+ +SE AP G
Sbjct: 432 PSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPG 491
Query: 273 TSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKK--VDFEHQNHY 330
+ + I A D D G NA + YSI + + I+ H G+V +D E +
Sbjct: 492 SYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEH---SGLVTTGSSGGLDRELASQI 548
Query: 331 GIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPY-YVFEVFEETPQGSF 388
+ ++ V H + S + + + DV DE P+F P Y V E P G+
Sbjct: 549 VLNISARDQGV-------HPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTE 601
Query: 389 VGVVSATDPD-NRKSPIRYSI----TRSKVFNIND-NGTITTSNSLDREISAWYNLSITA 442
+ ++ ATD D +R+S+ T + F ++ +G ++T +SLDRE A+Y+L + A
Sbjct: 602 LLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLA 661
Query: 443 TEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTISAVDRDESIE 501
T+ + Q S + V +L+IND++P F Y ++ EN G I T+SA D D
Sbjct: 662 TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 502 EHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLT 561
Y S+ + S F + + + +++ R + +E+ + + I+ D G
Sbjct: 722 GTVKY---SISAGDRSRFQV----NAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSP 774
Query: 562 STNTLTIHVCDCGDS 576
+ +TI V D D+
Sbjct: 775 NQAIVTITVLDTQDN 789
Score = 179 bits (454), Expect = 9e-45
Identities = 162/555 (29%), Positives = 254/555 (45%), Gaps = 52/555 (9%)
Query: 54 EEMNTTSHHIGQLRSDLDNG-NNSFQYKLLGAGAGSTFIIDERTGDIYAIQK--LDREER 110
EE S+ G +D D+G N + +Y ++ F I E +G + LDRE
Sbjct: 486 EEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELA 545
Query: 111 SLYILRAQVIDIATGRAVEPE---SEFVIKVSDINDNEPKFLD-EPYEAIVPEMSPEGTL 166
S +L D + V P+ ++ V+ + D+ND +P F E Y+ V E +P GT
Sbjct: 546 SQIVLNISARD----QGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTE 601
Query: 167 VIQVTASDADDPSSGNNARLLYSLLQGQP---YFSVEPTTGVIRISSKMDRELQDEYWVI 223
++ + A+D D G+N + +SL + + F ++P +G + S +DRE Q Y ++
Sbjct: 602 LLMLRATDGD---LGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLL 658
Query: 224 IQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDN 283
+ A D+ P S + + L D+NDN P+F Y + E+ P G+ I T+ A D
Sbjct: 659 VLATDLGSPPQ--SSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDP 716
Query: 284 DIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVK---NHH 340
D+G N + YSI D F + Q G++ + +D E + Y ++ N
Sbjct: 717 DLGTNGTVKYSISAGDRSRFQV----NAQSGVISTRMALDREEKTAYQLQIVATDGGNLQ 772
Query: 341 VPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNR 400
P Q + T T D PP+F Y F VFE G VG VSA+ D
Sbjct: 773 SPNQAIVTITVLDTQ---------DNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD-L 822
Query: 401 KSPIRYSIT---RSKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPL 456
S I Y IT + +F IN G +TT+N +DRE ++Y L + A+ +
Sbjct: 823 NSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG---TVTGDTMV 879
Query: 457 YVQVLNINDHAPEFSQYYETY-VCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTN 515
+ V ++ND++P F Q E+ V EN +G I AVD DE + Y S++
Sbjct: 880 NITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLY---SLKQNP 936
Query: 516 NSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGD 575
+ F I N+ N + L + + I IL +D G+P L+S+ LT++V D D
Sbjct: 937 KNLFAI--NEKNGTISLLGPLDVHAGS---YQIEILASDMGVPQLSSSVILTVYVHDVND 991
Query: 576 SGSTQTCQYQELVLS 590
+ E+ LS
Sbjct: 992 NSPVFDQLSYEVTLS 1006
Score = 177 bits (450), Expect = 3e-44
Identities = 156/540 (28%), Positives = 254/540 (47%), Gaps = 42/540 (7%)
Query: 51 FVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREER 110
FV E +H+G + + + N++ Y + F I++ TG + +DREE+
Sbjct: 800 FVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQ 859
Query: 111 SLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQV 170
S Y L+ +A+G V ++ I V D+NDN P FL V E G + Q
Sbjct: 860 SFYQLKV----VASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQ- 914
Query: 171 TASDADDPSSGNNARLLYSLLQG-QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
+ A DP G N +LYSL Q + F++ G I + +D Y + I A DM
Sbjct: 915 --AKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVH-AGSYQIEILASDM 971
Query: 230 IGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENA 289
G P LS + + + + DVNDN P+F + Y +T+SES P + + A D D G N
Sbjct: 972 -GVP-QLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANG 1029
Query: 290 EMDYSIEEDDS-QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKY 348
E+ Y+I E ++ F I +G + +K ++D E Q+ Y + V + E L
Sbjct: 1030 EIAYTIAEGNTGDAFGIF-----PDGQLYIKSELDRELQDRY-VLMVVASDRAVEPL--- 1080
Query: 349 HTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRY 406
++T + + +EDV D PLF Y F EE GSFVG VSA D D +RY
Sbjct: 1081 ---SATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRY 1137
Query: 407 SITRSKV-FNIND-NGTITTSNSLDREI------SAWYNLSITATEKYNIEQI-SSIPLY 457
S + F ++ +G IT ++ DRE +A ++ ++ AT++ + + ++
Sbjct: 1138 SFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVH 1197
Query: 458 VQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNN 516
V + +IND+AP+F +Y+ + E+A + + +SA D DE ++ + S+ N
Sbjct: 1198 VYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEG---NNGLIHYSIIKGNE 1254
Query: 517 SSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
ID+ ++ + + P + + I D+G L ST TL I + D D+
Sbjct: 1255 ERQFAIDSTSGQVTLIGK---LDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDN 1311
Score = 171 bits (432), Expect = 3e-42
Identities = 156/535 (29%), Positives = 245/535 (45%), Gaps = 47/535 (8%)
Query: 61 HHIGQLRS-DLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQV 119
H I Q ++ D D G N L + F I+E+ G I + LD S Q+
Sbjct: 910 HSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGSY-----QI 964
Query: 120 IDIATGRAVEPESEFVIK---VSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDAD 176
+A+ V S VI V D+NDN P F YE + E P + +V ASD D
Sbjct: 965 EILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKD 1024
Query: 177 DPSSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPG 234
SG N + Y++ +G F + P G + I S++DRELQD Y +++ A D +P
Sbjct: 1025 ---SGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEP- 1079
Query: 235 ALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYS 294
LS T +V + L DVNDN+P+F + Y E G+ +G + A D D G N E+ YS
Sbjct: 1080 -LSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYS 1138
Query: 295 IE--EDDSQTFDI---ITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYH 349
E + D + I ITN + +++++ + + +P+ L
Sbjct: 1139 FEMVQPDFELHAISGEITNTHQFDRESLMRRR----GTAVFSFTVIATDQGIPQPLKDQA 1194
Query: 350 TEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYS 407
T + + ++D+ D P FL +Y + E + V VSA+D D I YS
Sbjct: 1195 T------VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYS 1248
Query: 408 ITR---SKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNI 463
I + + F I+ +G +T LD E + Y+L I A + I S+ L + +L+
Sbjct: 1249 IIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDE 1308
Query: 464 NDHAPEF-SQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNN-SSFTI 521
ND+ P F V EN G+++ +++A D D +Y S+ TNN +F+I
Sbjct: 1309 NDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYY---SITGTNNHGTFSI 1365
Query: 522 IDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
N ++ L + F Q ++ ++I D G P +ST ++ IHV D D+
Sbjct: 1366 SPN--TGSIFLAKKLDFETQS--LYKLNITAKDQGRPPRSSTMSVVIHVRDFNDN 1416
Score = 166 bits (421), Expect = 6e-41
Identities = 150/538 (27%), Positives = 243/538 (45%), Gaps = 47/538 (8%)
Query: 69 DLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
D D G NS +Y + F +D TG I L + + + D
Sbjct: 3010 DKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP-P 3068
Query: 128 VEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLL 187
+ ++ I V++ N + P+F A +PE G++V V+A D D + N +
Sbjct: 3069 LSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRD---AAMNGLIK 3125
Query: 188 YSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIK 245
YS+ G + F++ +TG++ ++ +D EL ++ + I A D G A +G SV +
Sbjct: 3126 YSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAID--GGWVARTGYCSVTVN 3183
Query: 246 LSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDI 305
+ DVNDN P+F Y TV E+AP+GT++ + A D D G NA + Y+++ DS F I
Sbjct: 3184 VIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVI 3243
Query: 306 ITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVD 365
N G++ + +DFE + Y + K N VP++ S + IQ++ +
Sbjct: 3244 DPN----TGVITTQGFLDFETKQSYHLTVKAFN--VPDE-----ERCSFATVNIQLKGTN 3292
Query: 366 E-PPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSI---TRSKVFNIN-DN 419
E P F+ Y FE+ E P+G+ VG V A+D D + Y I +R K F IN
Sbjct: 3293 EYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKT 3352
Query: 420 GTITTSNSLDREISAWYNLSITATEKYNIE--QISSIPLYVQVLNINDHAPEFSQYYETY 477
G I S LDRE +L + A +I I + + V VL+ ND Y
Sbjct: 3353 GQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQ 3412
Query: 478 VCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTG 537
+ E G + +SA D D S+ + S+ I +N A + +TG
Sbjct: 3413 ISEGVPIGTHVTFVSAFDSD------------SIPSWSRFSYFIGSGNENGAFSINPQTG 3460
Query: 538 -------FNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELV 588
+ + P++ +S+L D+G PS T + +L + + D D+G T E++
Sbjct: 3461 QITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM 3518
Score = 165 bits (418), Expect = 1e-40
Identities = 150/521 (28%), Positives = 254/521 (48%), Gaps = 39/521 (7%)
Query: 68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
+D D+G NS Y + + F +D + G + ++ LDRE +S Y L QV D+
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIP 2027
Query: 127 AVEPESEFVIKVS--DINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNA 184
A S + + D+NDN P FL P +PE +P T+V + A+D P SG N+
Sbjct: 2028 ASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATD---PDSGPNS 2083
Query: 185 RLLYSLLQGQPY-FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVL 243
+ Y+LL FS+ G +R++ ++DRE Y + + A D GQP +LS +T V+
Sbjct: 2084 YIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDK-GQP-SLSSSTEVV 2141
Query: 244 IKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQT 302
+ + D+NDN PIF ++LY++ ++E+ TGT I + A D D G N ++ Y I + +Q
Sbjct: 2142 VMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQE 2201
Query: 303 FDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVE 362
F I ++ G + + K +D E Y + + + + T+ ST I + ++
Sbjct: 2202 FRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR-----TDTSTVSI-VLLD 2251
Query: 363 DVDEPPLFLLPYYVFEVFEE--TPQGSFVGVVSATDPDNRKSPIRYSI---TRSKVFNIN 417
D P+F L Y V E T + + VV+ D S + Y + F ++
Sbjct: 2252 INDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS 2311
Query: 418 DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYET 476
+G + + SLDRE + L ITAT+ + + + V V ++ND+ P F S+ Y T
Sbjct: 2312 ASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFT 2371
Query: 477 YVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRT 536
+ E+A +G + ++A D D S NS FTI +T I+T+
Sbjct: 2372 TIPEDAPTGTDVLLVNASDADASKNAVIRIIG------GNSQFTI---NPSTGQIITSAL 2422
Query: 537 GFNLQEEPVFYISILIADNGIPS-LTSTNTLTIHVCDCGDS 576
+ + + + + ++ +D G P L+S+ ++ + V D D+
Sbjct: 2423 -LDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDN 2462
Score = 156 bits (395), Expect = 6e-38
Identities = 157/568 (27%), Positives = 247/568 (43%), Gaps = 52/568 (9%)
Query: 25 NSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNG-NNSFQYKLLG 83
N T K +PV S F +PE+ S L +D D+G N Y +
Sbjct: 1835 NDHTPKFSRPVYS------------FDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNE 1882
Query: 84 AGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDIND 143
F ++ TG + LD E + YIL + D G + D+ND
Sbjct: 1883 DDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAED---GGGQFTTIRVYFNILDVND 1939
Query: 144 NEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPY--FSVEP 201
N P F Y + E P G+ V+ +DADD G N++L YS+ G F+V+
Sbjct: 1940 NPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADD---GINSQLTYSIASGDSLGQFTVDK 1996
Query: 202 TTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGA-LSGTTSVLIKLSDVNDNKPIFKESL 260
GV+++ +DRE Q Y +++Q D+ P + + T V I L DVNDN P F
Sbjct: 1997 N-GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSP- 2054
Query: 261 YRLT-VSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILK 319
+LT + E+ P T + A D D G N+ ++Y++ F I T +G V L
Sbjct: 2055 -KLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSI----GTIDGEVRLT 2109
Query: 320 KKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFE 378
++D E ++Y + + P +S+T + + V D+ D P+F Y E
Sbjct: 2110 GELDREEVSNYTLTVVATDKGQPSL-------SSSTEVVVMVLDINDNNPIFAQALYKVE 2162
Query: 379 VFEETPQGSFVGVVSATDPDN-RKSPIRYSITRSKV---FNIND-NGTITTSNSLDREIS 433
+ E T G+ + V A D D +RY I F I+ G IT + LDRE +
Sbjct: 2163 INENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKT 2222
Query: 434 AWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFS-QYYETYVCENAGS-GQVIQTI 491
Y+L++ AT++ + + + + + +L+IND P F Y V EN G+ + I +
Sbjct: 2223 PTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQV 2282
Query: 492 SAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISIL 551
A D D Y + N +FT+ + + L + + + F + I
Sbjct: 2283 VARDDDRGSNSKLSYVLFGGNEDN--AFTLSASGE-----LGVTQSLDRETKERFVLMIT 2335
Query: 552 IADNGIPSLTSTNTLTIHVCDCGDSGST 579
D+G P+LT T T+ + V D D+ T
Sbjct: 2336 ATDSGSPALTGTGTINVIVDDVNDNVPT 2363
Score = 154 bits (390), Expect = 2e-37
Identities = 163/572 (28%), Positives = 253/572 (44%), Gaps = 79/572 (13%)
Query: 68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
+D D+G+N+ Y + G TF I TG I+ +KLD E +SLY L D GR
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKD--QGR 1397
Query: 127 AVEPES-EFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNAR 185
+ VI V D NDN P F + E P GT VI VT A DP + N +
Sbjct: 1398 PPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVT---AHDPDADINGQ 1454
Query: 186 LLYSLLQGQP---YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM-IGQPGALSGTTS 241
L Y+++Q P +F+++ G I ++++DRE + + + ++A D + +
Sbjct: 1455 LSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKN 1514
Query: 242 VLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ 301
V I ++D+NDN P+F S L SA G+ + TIMA D D G N E++Y I D+
Sbjct: 1515 VTILVTDLNDNVPMF-ISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD 1573
Query: 302 TFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQL----------MKYHTE 351
TF + + Y +V + VP QL +
Sbjct: 1574 TFIV----------------------DRYSGDLRVASALVPSQLIYNLIVSATDLGPERR 1611
Query: 352 ASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSI--- 408
STT + I ++ +D P+F P Y+ + E P G+ V + A P ++P+ Y I
Sbjct: 1612 KSTTELTIILQGLD-GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSV 1670
Query: 409 -----TRSKVFNI-NDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIP------L 456
T ++F I G I T+ LDRE A L + Y IE+ ++ P +
Sbjct: 1671 RCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYL----VDVYAIEKSTAFPRTQRAEV 1726
Query: 457 YVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTN 515
+ + +IND+ P F + + V EN G G I ++A+D DE Y +S D
Sbjct: 1727 EITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGAD-- 1784
Query: 516 NSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGD 575
SF I + ++ +I T R +E Y ++ AD+G+ S S + I V D D
Sbjct: 1785 -DSFRI--DPESGDLIATRRLD---RERRSKYSLLVRADDGLQS--SDMRINITVSDVND 1836
Query: 576 SGSTQTCQYQELVLSMGFKTEVIIAILICIMI 607
T ++ V S + I L+ ++
Sbjct: 1837 ----HTPKFSRPVYSFDIPEDTIPGSLVAAIL 1864
Score = 142 bits (357), Expect = 2e-33
Identities = 140/537 (26%), Positives = 240/537 (44%), Gaps = 67/537 (12%)
Query: 77 FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVI 136
F Y+L + A F I+ TG +Y +DRE ++ V+ A E +
Sbjct: 70 FTYRLSESHA--LFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR----V 123
Query: 137 KVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPY 196
V D+NDN P F D E S G VI TA+D+D S+G + R Y +++G
Sbjct: 124 LVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRS-YRIIRGNEA 182
Query: 197 --FSVEPTTG------VIRISSK--MDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKL 246
F ++ T + + SK +DRE+ +Y ++++ +D G+P G V + +
Sbjct: 183 GRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDK-GEPKR-RGYLQVNVTV 240
Query: 247 SDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDII 306
D+NDN P+F S Y+ V E A G+S+ + A D D G NA++ Y + +D+ F +
Sbjct: 241 QDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL-QDEGTPFQM- 298
Query: 307 TNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-D 365
+ + G++ +++ +DFE + Y + + + VP + EA IQ+ DV D
Sbjct: 299 ---DPETGLITVREPLDFEARRQYSLTVQAMDRGVPS--LTGRAEA-----LIQLLDVND 348
Query: 366 EPPLFLLPYY-----VFEVFEETPQGSFVGVVSATDPDN-------------RKSPIRYS 407
P+ Y+ V E G+ V +++ TD D+ +
Sbjct: 349 NDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFE 408
Query: 408 ITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYN------IEQISSI-PLYVQV 460
+ SKV N++ I +++LDRE YNL+++ ++ Y ++ SS+ L + V
Sbjct: 409 VQSSKVPNLS---LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFV 465
Query: 461 LNINDHAPEFS-QYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSF 519
+INDH P FS Q Y + E A G + ISA D D + NL + +
Sbjct: 466 NDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNA-----NLRYSIVSGNGL 520
Query: 520 TIIDNQDNTAVILTNRT-GFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGD 575
+++ ++ T + G + + ++I D G+ S L + + D D
Sbjct: 521 GWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVND 577
Score = 139 bits (349), Expect = 1e-32
Identities = 139/484 (28%), Positives = 226/484 (46%), Gaps = 46/484 (9%)
Query: 68 SDLDNGNNSF-QYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
SD D G N+ +Y ++ A F I+ TGDI + L+RE+ Y +R D +G
Sbjct: 2797 SDEDIGINAISRYSIMDASL--PFTINPSTGDIVISRPLNREDTDRYRIRVSAHD--SGW 2852
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
V ++ I V+DINDN P+F Y PE++ G+ V QV A+ DP G+N ++
Sbjct: 2853 TVS--TDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFAT---DPDEGSNGQV 2907
Query: 187 LYSLLQGQPYFSVEPTTGVIRISSKMDRELQ----------DEYWVIIQAKDMIGQPGAL 236
Y + YF + TTG I +K + Q + + I+ + D G+P +
Sbjct: 2908 FYFIKSQSEYFRINATTG--EIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR-GKPSLI 2964
Query: 237 SGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDN-DIGENAEMDYSI 295
S TT V I + D NDN P F +S Y V+++ GT + + A D+ D G N+E++Y I
Sbjct: 2965 SETT-VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFI 3023
Query: 296 EEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTT 355
D+ + N G + + + + ++ I K+ P + +T
Sbjct: 3024 SNDNHLGKFKLDN---DTGWISVASSLISDLNQNFFITVTAKDKGNPPL-----SSQATV 3075
Query: 356 FIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSP-IRYSITRSK-- 412
I + E+ P F + + E GS V VSA D D + I+YSI+
Sbjct: 3076 HITVTEENYHTPE-FSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEE 3134
Query: 413 -VFNINDN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF 470
+F IN + G +T + +LD E+ + ++I+A + + + + V V+++ND++P F
Sbjct: 3135 GIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF 3194
Query: 471 -SQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTA 529
S Y V ENA SG + ++A D D Y +V+ +++ F I NT
Sbjct: 3195 LSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAY---TVQSSDSDLFVI---DPNTG 3248
Query: 530 VILT 533
VI T
Sbjct: 3249 VITT 3252
Score = 138 bits (348), Expect = 2e-32
Identities = 145/530 (27%), Positives = 228/530 (43%), Gaps = 58/530 (10%)
Query: 68 SDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
+D D G N + AG S F ++ ++G I LDREE++ Y L Q++ G
Sbjct: 714 TDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQL--QIVATDGGNL 771
Query: 128 VEPESEFV-IKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
P V I V D DN P F Y +V E G V V+AS D N+ +
Sbjct: 772 QSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD-----LNSNI 826
Query: 187 LYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLI 244
Y + G F++ TG + ++ +DRE Q Y + + A G ++G T V I
Sbjct: 827 SYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASG-----GTVTGDTMVNI 881
Query: 245 KLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFD 304
+ D+NDN P F +++ + V E+ G SI A D D G N + YS++++ F
Sbjct: 882 TVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFA 941
Query: 305 IITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV 364
I + G + L +D H Y I + VP+ +S+ + + V DV
Sbjct: 942 I----NEKNGTISLLGPLDV-HAGSYQIEILASDMGVPQL-------SSSVILTVYVHDV 989
Query: 365 -DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDN-RKSPIRYSITRSK---VFNINDN 419
D P+F Y + E P S V A+D D+ I Y+I F I +
Sbjct: 990 NDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPD 1049
Query: 420 GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYV 478
G + + LDRE+ Y L + A+++ +++ + V + ++ND+ P F S Y Y
Sbjct: 1050 GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYF 1109
Query: 479 CENAGSGQVIQTISAVDRD-----------ESIEEHHFYFNLSVEDTNNSSFTIIDNQDN 527
E +G + +SAVD+D E ++ +S E TN F D +
Sbjct: 1110 EEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQF---DRES- 1165
Query: 528 TAVILTNRTGFNLQEEPVFYISILIADNGIPS-LTSTNTLTIHVCDCGDS 576
L R G VF +++ D GIP L T+ +++ D D+
Sbjct: 1166 ----LMRRRG-----TAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDN 1206
Score = 127 bits (320), Expect = 3e-29
Identities = 140/534 (26%), Positives = 229/534 (42%), Gaps = 47/534 (8%)
Query: 52 VPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERS 111
+PE+ T + + SD D N+ + G S F I+ TG I LDRE +
Sbjct: 2373 IPEDAPTGTDVLLVNASDADASKNAV---IRIIGGNSQFTINPSTGQIITSALLDRETKD 2429
Query: 112 LYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVT 171
Y L D + + + ++ V+D+NDN P+F PY +P + G+ V VT
Sbjct: 2430 NYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVT 2489
Query: 172 ASDADDPSSGNNARLLYSLL-QGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 230
+DAD G N+ L YSL + F ++P G I + ++ E + KD
Sbjct: 2490 VTDAD---IGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNG--ASEVTFSVHVKD-- 2542
Query: 231 GQPGALSGTTSVLIKLSDVND-NKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENA 289
G+ T S + + VN + P + E+ P + + TI
Sbjct: 2543 --GGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSL---RGE 2597
Query: 290 EMDYSIEEDD-SQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKY 348
M Y I + TF I + G V + + +DFE Y + + ++ P
Sbjct: 2598 PMSYYIASGNLGNTFQI----DQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP------ 2647
Query: 349 HTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDN-RKSPIRY 406
+S + I V DV D P+F ++ E+ E + VSA D D+ + Y
Sbjct: 2648 -PFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDY 2705
Query: 407 SITRSKV---FNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLN 462
I + F+IN G I + LDRE + Y L+I +++K + Q +S+ + + +L+
Sbjct: 2706 EIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILD 2765
Query: 463 INDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTII 522
ND+AP FSQ + +V EN+ G + ++ D D I Y S+ D + FTI
Sbjct: 2766 ENDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRY---SIMDA-SLPFTI- 2820
Query: 523 DNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+T I+ +R N ++ + I + D+G T + +TI V D D+
Sbjct: 2821 --NPSTGDIVISRP-LNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDN 2868
Score = 124 bits (310), Expect = 4e-28
Identities = 144/521 (27%), Positives = 224/521 (42%), Gaps = 44/521 (8%)
Query: 68 SDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
+D D G NS + L F ID G I A L+ + + + G +
Sbjct: 2491 TDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFS-----VHVKDGGS 2545
Query: 128 VEPESEFVIKVSDINDNE-PKFLDEPYEAIVPEMSPEGTLVIQVTASDA-DDPSSGNNAR 185
+ V +N + PK + + PE P +LV +T S +P S
Sbjct: 2546 FPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMS----- 2600
Query: 186 LLYSLLQGQ--PYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVL 243
Y + G F ++ TG + IS +D E +Y V I+A+D G S +
Sbjct: 2601 --YYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARD--GGFPPFSSYEKLD 2656
Query: 244 IKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-T 302
I + DVNDN PIFKE + + E+ + I T+ A D D G N ++DY I + + +
Sbjct: 2657 ITVLDVNDNAPIFKEDPFISEILENL-SPRKILTVSAMDKDSGPNGQLDYEIVNGNMENS 2715
Query: 303 FDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVE 362
F I NH T E + + +D E +HY + K + P Q +T +K+ +
Sbjct: 2716 FSI--NHATGE--IRSVRPLDREKVSHYVLTIKSSDKGSPSQ---------STSVKVMIN 2762
Query: 363 DVDE---PPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPI-RYSITRSKV-FNIN 417
+DE P F + V E +P G V V+ +D D + I RYSI + + F IN
Sbjct: 2763 ILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTIN 2821
Query: 418 DN-GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYET 476
+ G I S L+RE + Y + ++A ++ S + + V +IND+AP FS+
Sbjct: 2822 PSTGDIVISRPLNREDTDRYRIRVSA---HDSGWTVSTDVTIFVTDINDNAPRFSRTSYY 2878
Query: 477 YVC-ENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNR 535
C E G + + A D DE FYF S + + T + + + N
Sbjct: 2879 LDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNV 2938
Query: 536 TGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
TGF+ + +D G PSL S T+TI++ D D+
Sbjct: 2939 TGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDN 2979
Score = 62.8 bits (151), Expect = 1e-09
Identities = 81/337 (24%), Positives = 132/337 (39%), Gaps = 47/337 (13%)
Query: 265 VSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDF 324
V E P GT +GTI Y + E + F I + G + +D
Sbjct: 51 VLEEQPPGTLVGTIQTRPG-------FTYRLSESHA-LFAI----NSSTGALYTTSTIDR 98
Query: 325 EHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEET 383
E + + V N V Y TE +++ V D+ D P+F P V E++
Sbjct: 99 E-----SLPSDVINLVVLSSAPTYPTE-----VRVLVRDLNDNAPVFPDPSIVVTFKEDS 148
Query: 384 PQGSFVGVVSATDPDNRKSPI---RYSITRSKV-------FNINDNGT-----ITTSNSL 428
G V + +ATD D + + Y I R +N +G + + L
Sbjct: 149 SSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGL 208
Query: 429 DREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQV 487
DRE++ Y L + +K ++ + + V V +IND+ P F S +Y+ V E+A G
Sbjct: 209 DREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSS 268
Query: 488 IQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFY 547
+ ++A D DE Y L E T D ++T R + + +
Sbjct: 269 VLQVAAADADEGTNADIRY-RLQDEGTPFQ-------MDPETGLITVREPLDFEARRQYS 320
Query: 548 ISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQY 584
+++ D G+PSLT I + D D+ +Y
Sbjct: 321 LTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRY 357
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 26/216 (12%)
Query: 373 PYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRS-KVFNINDN-GTITTSNSLDR 430
P VF+V EE P G+ VG + + Y ++ S +F IN + G + T++++DR
Sbjct: 45 PRQVFQVLEEQPPGTLVGTIQT------RPGFTYRLSESHALFAINSSTGALYTTSTIDR 98
Query: 431 EISAWYNLSITATEKYNIEQISSIPLY-----VQVLNINDHAPEF-SQYYETYVCENAGS 484
E ++ N+ +SS P Y V V ++ND+AP F E++ S
Sbjct: 99 E--------SLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSS 150
Query: 485 GQVIQTISAVDRD--ESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVI--LTNRTGFNL 540
G+ + +A D D + +H Y + + I N L ++ G +
Sbjct: 151 GRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDR 210
Query: 541 QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+ P + + + + D G P + + V D D+
Sbjct: 211 EVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDN 246
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 186 bits (472), Expect = 7e-47
Identities = 146/516 (28%), Positives = 244/516 (47%), Gaps = 24/516 (4%)
Query: 68 SDLDNG-NNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
+D D G N Y + F I+ TG + LD E + YIL V D+ T +
Sbjct: 740 TDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQ 799
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
+ + V D NDN P+F Y+ + E + GT + ++T DAD S +N R+
Sbjct: 800 KSSWKL-LTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDAD---SEDNGRV 855
Query: 187 LYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKL 246
Y+LL FS+ P TG + ++ +DRE + Y + ++A+D + L T ++I L
Sbjct: 856 RYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITL 915
Query: 247 SDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDII 306
DVNDN P RL V E P GT + + A D D+G E+ Y + + TF +
Sbjct: 916 EDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRV- 974
Query: 307 TNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDE 366
+ G +IL++++DFE + Y + + P + T I + V +
Sbjct: 975 ---DLMTGALILERELDFERRAGYNLSLWASDGGRP---LARRTLCHVEVIVLDVNENLH 1028
Query: 367 PPLFLLPYYVFEVFEETPQGSFVGVVSATDPDN-RKSPIRYSI---TRSKVFNIN-DNGT 421
PP F + +V E +P G+ V VV+A D D+ ++Y + T F+IN D G
Sbjct: 1029 PPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM 1088
Query: 422 ITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCE 480
I T LDRE +++Y L++ A ++ ++ S +Y++V + ND+ P+ SQ + + E
Sbjct: 1089 IQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQE 1148
Query: 481 NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL 540
+A G + + A D D S + FN++ N F +I +L+ +
Sbjct: 1149 DAPVGTSVLQLDAWDPDSS-SKGKLTFNIT--SGNYMGFFMI---HPVTGLLSTAQQLDR 1202
Query: 541 QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+ + + + + DNG PSL ST+ + + + D D+
Sbjct: 1203 ENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDN 1238
Score = 152 bits (383), Expect = 1e-36
Identities = 136/518 (26%), Positives = 234/518 (45%), Gaps = 43/518 (8%)
Query: 68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
+DLD N+ Y L G GA F +D TG++ + LDRE + ++ L A+ D G
Sbjct: 3036 TDLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATD---GG 3091
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
+++ + V D+NDN P+F V + + T+ V A DP G NA++
Sbjct: 3092 GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT---TVKTPVAVVFARDPDQGANAQV 3148
Query: 187 LYSLL-QGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIK 245
+YSL + +FS++ TTGVIR+ + Q + ++A D +G P LS +V +
Sbjct: 3149 VYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASD-LGTPIPLSTLGTVTVS 3207
Query: 246 LSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFD 304
+ + D P+F + + + V E AP GT + + E + Y + + Q F
Sbjct: 3208 VVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGYRVVSGNEQGRFR 3265
Query: 305 IITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV 364
+ + + GI+ + +DFE Y + + + + T + + + DV
Sbjct: 3266 L----DARTGILYVNASLDFETSPKYFLSIECSR-------KSSSSLSDVTTVMVNITDV 3314
Query: 365 DE-PPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKV-------FNI 416
+E P F Y V E G + VSATD D P+ IT S + F I
Sbjct: 3315 NEHRPQFPQDPYSTRVLENALVGDVILTVSATDED---GPLNSDITYSLIGGNQLGHFTI 3371
Query: 417 N-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQY-Y 474
+ G + + +LDRE ++ Y+L + AT+ + +QV ++ND+ P F Q Y
Sbjct: 3372 HPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNY 3431
Query: 475 ETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTN 534
T V EN+ G + + D D + F ++ + N S+F + + L
Sbjct: 3432 STTVQENSPIGSKVLQLILSDPDSPENGPPYSFRIT-KGNNGSAFRVTPDG-----WLVT 3485
Query: 535 RTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCD 572
G + + + + + I +D+GIP L+S ++ +HV +
Sbjct: 3486 AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTE 3523
Score = 147 bits (372), Expect = 3e-35
Identities = 139/515 (26%), Positives = 235/515 (45%), Gaps = 36/515 (6%)
Query: 69 DLDNGNNSFQYKLLGAGAG-STFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
D D+G + L AG G + F I++ TG I + LDRE S Y L +D +
Sbjct: 1058 DDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV-P 1116
Query: 128 VEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLL 187
+ +E I+V+D NDN P+ + + E +P GT V+Q+ DA DP S + +L
Sbjct: 1117 LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQL---DAWDPDSSSKGKLT 1173
Query: 188 YSLLQGQ--PYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIK 245
+++ G +F + P TG++ + ++DRE +DE+ + + D G+P +L T+ V++
Sbjct: 1174 FNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDN-GEP-SLKSTSRVVVG 1231
Query: 246 LSDVNDNKPIFKESLYRLTVSE--SAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTF 303
+ DVNDN PIF L+ + + E S + + ++A D D G N + YSIE+ D + F
Sbjct: 1232 ILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAF 1291
Query: 304 DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED 363
I + G+V N I+A ++ H E +
Sbjct: 1292 SI----DLVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSI-- 1345
Query: 364 VDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSIT---RSKVFNI-NDN 419
P F YY F V E P VGV+S + R ++I+ + F+I
Sbjct: 1346 ---PLAFDETYYSFTVMETDPVNHMVGVISV---EGRPGLFWFNISGGDKDMDFDIEKTT 1399
Query: 420 GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYV 478
G+I + LD + YNL++ T+ I++ + NIN H P+F + YE V
Sbjct: 1400 GSIVIARPLDTRRRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
Query: 479 CENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGF 538
++ G + + A+D+D+ + Y +D ++S +D V +
Sbjct: 1458 PQDTVPGVELLRVQAIDQDKG--KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGK---L 1512
Query: 539 NLQEEPVFY-ISILIADNGIPSLTSTNTLTIHVCD 572
+L P + +++++ D IP + +TIHV D
Sbjct: 1513 DLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVED 1547
Score = 144 bits (363), Expect = 3e-34
Identities = 120/418 (28%), Positives = 200/418 (47%), Gaps = 34/418 (8%)
Query: 90 FIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFL 149
F ID GDI + D + + Y L+ D T +++ E E ++ V N + P F
Sbjct: 2116 FRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTP-SLQSEEEVLVTVR--NKSNPLFQ 2172
Query: 150 DEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPY--FSVEPTTGVIR 207
Y+ VPE TL + + A P RL+Y++++ +P F+ + TGV+
Sbjct: 2173 SPYYKVRVPENI---TLYTPILHTQARSPEG---LRLIYNIVEEEPLMLFTTDFKTGVLT 2226
Query: 208 ISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSE 267
++ +D E + ++ ++A D G+ S T V + + DVNDN P F + +Y ++SE
Sbjct: 2227 VTGPLDYESKTKHVFTVRATDTA--LGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSISE 2283
Query: 268 SAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDII-TNHETQEGIVILKKKVDFEH 326
P T + ++A D D G N ++ Y I ED S N T E + +++D+E
Sbjct: 2284 GLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTV--QELDYEA 2341
Query: 327 QNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVFEVFEETPQ 385
Q H+ ++ + + P T + + V D+ D PP F P Y V E
Sbjct: 2342 QQHFHVKVRAMDKGDPPL-------TGETLVVVNVSDINDNPPEFRQPQYEANVSELATC 2394
Query: 386 GSFVGVVSATDPDNR-KSPIRYSI---TRSKVFNIN-DNGTITTSNSLDREISAWYNLSI 440
G V V A DPD+R S + Y I + + F IN +G I+ N + + + YNL +
Sbjct: 2395 GHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRV 2454
Query: 441 TATEKYNIEQISSIPLYVQVLNINDHAPEFSQY-YETYVCENAGSGQVIQTISAVDRD 497
A++ +++P+Y+ N N ++PEF Q+ YE + ENA G + + A+D+D
Sbjct: 2455 GASDGV---FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKD 2509
Score = 137 bits (344), Expect = 5e-32
Identities = 120/449 (26%), Positives = 199/449 (44%), Gaps = 46/449 (10%)
Query: 146 PKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP-------YFS 198
PKF + Y PE PEG+ + V A A DP ++YSL++G FS
Sbjct: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFS 2741
Query: 199 VEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKE 258
++P TGVI++ MD E Y + + A + Q + SV I++ DVNDN+P+F+
Sbjct: 2742 LDPDTGVIKVRKPMDHESTKLYQIDVMAHCL--QNTDVVSLVSVNIQVGDVNDNRPVFEA 2799
Query: 259 SLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVIL 318
Y+ ++E+ P GTS+ + A D D G + ++ Y + D + +++ G +
Sbjct: 2800 DPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITT 2859
Query: 319 KKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPYYVF 377
+++D E Y +H QL +S +++ + D D P F Y
Sbjct: 2860 LQELDCETCQTYHFHVVAYDHGQTIQL------SSQALVQVSITDENDNAPRFASEEYRG 2913
Query: 378 EVFEETPQGSFVGVVSATDPD--NRKSPIRYSITRSK------VFNINDNGTITTSNSLD 429
V E + G V + D D + + IT + + D I++ +LD
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
Query: 430 REISAWYNLSITATE-KYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQV 487
RE +A Y L +TA++ K+ +S+ + + VL++ND++P+ SQ Y V E+ G
Sbjct: 2974 REHTAKYLLRVTASDGKFQ----ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHF 3029
Query: 488 IQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFY 547
I +SA D D Y S+ F + D LT T + + + VF
Sbjct: 3030 ILKVSATDLDTDTNAQITY---SLHGPGAHEFKL----DPHTGELTTLTALDRERKDVFN 3082
Query: 548 ISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+ D G S + +T+HV D D+
Sbjct: 3083 LVAKATDGGGRSCQA--DITLHVEDVNDN 3109
Score = 132 bits (332), Expect = 1e-30
Identities = 132/481 (27%), Positives = 214/481 (44%), Gaps = 46/481 (9%)
Query: 55 EMNTTSHHIGQLRS-DLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSL 112
E+ T H + ++++ D D+ + S +Y +L F I+ +G I + S
Sbjct: 2390 ELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSS 2449
Query: 113 YILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTA 172
Y LR D RA P I ++ N P+F YEA + E + GT VI + A
Sbjct: 2450 YNLRVGASD-GVFRATVP---VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLA 2505
Query: 173 SDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQ 232
D D G + + L + FS+ P G I K+DRE E +I K M
Sbjct: 2506 IDKDSGPYGTIDYTIINKLASEK-FSINPN-GQIATLQKLDRENSTER--VIAIKVMARD 2561
Query: 233 PGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMD 292
G +V I L+D NDN P FK S Y +++ + + + ++AYD D G+NA++
Sbjct: 2562 GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVT 2621
Query: 293 YSIEEDDSQTFDIITNHETQEGIVILKKK-VDFEHQN-HYGIRAKVK-----NHHVPEQL 345
YS+ +D I N T G+V +K V E+Q + I+A+ N VP +L
Sbjct: 2622 YSVNPEDLVKDVIEINPVT--GVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRL 2679
Query: 346 MKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIR 405
+ S P F P Y F E+ P+GS +G+V A + P+
Sbjct: 2680 QVVPKKVSL-------------PKFSEPLYTFSAPEDLPEGSEIGIVKAV---AAQDPVI 2723
Query: 406 YSITRSK--------VFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPL 456
YS+ R VF+++ D G I +D E + Y + + A N + +S + +
Sbjct: 2724 YSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSV 2783
Query: 457 YVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTN 515
+QV ++ND+ P F + Y+ + EN G + ++A+D+D + + LS + +
Sbjct: 2784 NIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTG-RDGQVSYRLSADPGS 2842
Query: 516 N 516
N
Sbjct: 2843 N 2843
Score = 131 bits (330), Expect = 2e-30
Identities = 123/467 (26%), Positives = 210/467 (44%), Gaps = 39/467 (8%)
Query: 69 DLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAV 128
D D G N+ L A F ID TG I + L ++ L + D+ T +
Sbjct: 3139 DPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPL 3198
Query: 129 EPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLY 188
+ V + D P FL+ + VPE +P GT V+Q+ A+ + R++
Sbjct: 3199 STLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL-ATLTRPGAEKTGYRVVS 3257
Query: 189 SLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSD 248
QG+ F ++ TG++ +++ +D E +Y++ I+ +LS T+V++ ++D
Sbjct: 3258 GNEQGR--FRLDARTGILYVNASLDFETSPKYFLSIECSRK--SSSSLSDVTTVMVNITD 3313
Query: 249 VNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITN 308
VN+++P F + Y V E+A G I T+ A D D N+++ YS+ + I
Sbjct: 3314 VNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTI-- 3371
Query: 309 HETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEP 367
++G + + K +D E + Y ++ + + P H + T I IQV DV D P
Sbjct: 3372 -HPKKGELQVAKALDREQASSYSLKLRATDSGQP----PLHED---TDIAIQVADVNDNP 3423
Query: 368 PLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKS--PIRYSITR---SKVFNINDNGTI 422
P F Y V E +P GS V + +DPD+ ++ P + IT+ F + +G +
Sbjct: 3424 PRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWL 3483
Query: 423 TTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYET------ 476
T+ L R WY L I A++ S IP + ++ H E S Y +
Sbjct: 3484 VTAEGLSRRAQEWYQLQIQASD-------SGIPPLSSLTSVRVHVTEQSHYAPSALPLEI 3536
Query: 477 --YVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTI 521
V E+ G ++ I A DRD + ++L+ E+T F++
Sbjct: 3537 FITVGEDEFQGGMVGKIHATDRD---PQDTLTYSLAEEETLGRHFSV 3580
Score = 129 bits (324), Expect = 1e-29
Identities = 133/555 (23%), Positives = 240/555 (43%), Gaps = 45/555 (8%)
Query: 51 FVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREER 110
F E + +H +G + ++ F + + G F I++ TG I + LD R
Sbjct: 1356 FTVMETDPVNHMVGVI--SVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRR 1413
Query: 111 SLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQV 170
S Y L +V D G + +++IN + P+FL+ YE VP+ + G +++V
Sbjct: 1414 SNYNLTVEVTD---GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRV 1470
Query: 171 TASDADDPSSGNNARLLYSLLQGQP-----YFSVEPTTGVIRISSKMDREL-QDEYWVII 224
A D D S L+Y++ Q F ++P++GV+ K+D ++ + +
Sbjct: 1471 QAIDQDKGKS-----LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTV 1525
Query: 225 QAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDND 284
+D + V I + D N + P F + Y +V ++ GT + + A D D
Sbjct: 1526 MVRDQ--EIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
Query: 285 IGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQ 344
G NAE+ YS+ + +S+ F N GI+ L +K+D + + + K ++ P+
Sbjct: 1584 RGVNAEVHYSLLKGNSEGF---FNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQ- 1639
Query: 345 LMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPI 404
+H + +T I + D P+F Y E+ E P GS + +VSA P +
Sbjct: 1640 ---WH-DLATVIIHVYPSD-RSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYEL 1694
Query: 405 RYSITRSKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNI 463
R + VF++N +G I+T LD E + Y L I + + + + V +++
Sbjct: 1695 REG-NKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG--AFTDVMVVVDIIDE 1751
Query: 464 NDHAPEFSQYYETYVCENAGSGQVIQTIS-------AVDRDESIEEHHFYFNLSVEDTNN 516
ND+AP F + T+V + + + + I + +S +E + + +
Sbjct: 1752 NDNAPMFLK--STFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEA 1809
Query: 517 SSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTN--TLTIHVCDCG 574
F ID T I++ + + P F + + D G P L + + IHV D
Sbjct: 1810 LKFFKIDPSMGTLTIVSE---MDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVN 1866
Query: 575 DSGSTQTCQYQELVL 589
DS + Q E+ +
Sbjct: 1867 DSPPRFSEQIYEVAI 1881
Score = 127 bits (318), Expect = 5e-29
Identities = 136/527 (25%), Positives = 232/527 (44%), Gaps = 44/527 (8%)
Query: 66 LRSDLDNGNN---SFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDI 122
L SD D+G N S+Q G+ F I+ TG++ +Q+LD E + + ++ + +D
Sbjct: 2295 LASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD- 2353
Query: 123 ATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGN 182
+ E+ V+ VSDINDN P+F YEA V E++ G LV++V A DP S +
Sbjct: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKV---QAIDPDSRD 2410
Query: 183 NARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTT 240
+RL Y +L G +F + ++G+I + + + L Y + + A D G T
Sbjct: 2411 TSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD-----GVFRATV 2465
Query: 241 SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYS-IEEDD 299
V I ++ N P F++ LY ++E+A GT + ++A D D G +DY+ I +
Sbjct: 2466 PVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLA 2525
Query: 300 SQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKI 359
S+ F I N G + +K+D E+ I KV ++ A T I
Sbjct: 2526 SEKFSINPN-----GQIATLQKLDRENSTERVIAIKVMARDGGGRV------AFCTVKII 2574
Query: 360 QVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR----SKVF 414
++ D PP F Y + + S V V A D D + + + YS+ V
Sbjct: 2575 LTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVI 2634
Query: 415 NIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQY 473
IN G + +SL + + I A + S +P+ +QV+ P+FS+
Sbjct: 2635 EINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEP 2694
Query: 474 YETYVC-ENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVIL 532
T+ E+ G I + AV + + ++L T S+ + + D ++
Sbjct: 2695 LYTFSAPEDLPEGSEIGIVKAVAAQDPV-----IYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Query: 533 TNRTGFNLQEEPVFYISIL---IADNGIPSLTSTNTLTIHVCDCGDS 576
R + + ++ I ++ + + + SL S N I V D D+
Sbjct: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN---IQVGDVNDN 2793
Score = 115 bits (288), Expect = 2e-25
Identities = 133/531 (25%), Positives = 219/531 (41%), Gaps = 61/531 (11%)
Query: 69 DLDNGNNSFQYKLLGAGAGST----FIIDERTGDIYAIQKLDREERSLYILRAQVIDIAT 124
D D G + L A GS F ID +G I +Q+LD E Y D
Sbjct: 2823 DKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYD--H 2880
Query: 125 GRAVEPESEFVIKVS--DINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGN 182
G+ ++ S+ +++VS D NDN P+F E Y V E S G LV + DAD S
Sbjct: 2881 GQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD--ISEQ 2938
Query: 183 NARLLYSLLQGQP--YFSVEPTTGVIRISSK--MDRELQDEYWVIIQAKDMIGQPGALSG 238
N ++ + +G P F + RISS+ +DRE +Y + + A D G
Sbjct: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASD-----GKFQA 2993
Query: 239 TTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEED 298
+ +V I + DVNDN P + LY V E G I + A D D NA++ YS+
Sbjct: 2994 SVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGP 3053
Query: 299 DSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIK 358
+ F + + G + +D E ++ + + AK + + I
Sbjct: 3054 GAHEFKL----DPHTGELTTLTALDRERKDVFNLVAKATDG---------GGRSCQADIT 3100
Query: 359 IQVEDV-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITRSKV--F 414
+ VEDV D P F + VF+ T + V VV A DPD + + YS+ S F
Sbjct: 3101 LHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHF 3160
Query: 415 NIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSI-PLYVQVLNINDHAPEF-S 471
+I+ G I L A L++ A++ +S++ + V V+ + D+ P F +
Sbjct: 3161 SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLN 3220
Query: 472 QYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVI 531
+ V E+A G + ++ + R + + ++ +
Sbjct: 3221 TEHSVQVPEDAPPGTEVLQLATLTR---------------PGAEKTGYRVVSGNEQGRFR 3265
Query: 532 LTNRTG-------FNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGD 575
L RTG + + P +++SI + SL+ T+ +++ D +
Sbjct: 3266 LDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNE 3316
Score = 108 bits (271), Expect = 1e-23
Identities = 123/472 (26%), Positives = 206/472 (43%), Gaps = 65/472 (13%)
Query: 76 SFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFV 135
+ QY L + F ++ RTG I + +D +R+ Y L I + G+A + V
Sbjct: 392 NLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLH---IRTSPGQA---STVVV 445
Query: 136 IKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP 195
I + D N++ P F Y+ + E P GT V+ VTA+D D G N + YS+ +
Sbjct: 446 IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDH---GENGYVTYSIAGPKA 502
Query: 196 Y-FSVEPTTGVIRISSKMDRELQDEYWVI-IQAKDMIGQPGALSGTTSVLIKLSDVNDNK 253
FS++P G+I S MD EL + ++A D G P S+ ++L ++NDN+
Sbjct: 503 LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDW-GSPFRREKEVSIFLQLRNLNDNQ 561
Query: 254 PIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQE 313
P+F+E ++ + P G SI T+ A D D +N + + + ++ + FD+ NH +
Sbjct: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEI-VSGNELEYFDL--NHFS-- 616
Query: 314 GIVILKK---KVDFEHQNHYGIRAKV---KNHHVPEQL---------------------M 346
G++ LK+ + Y ++ KN+ P L +
Sbjct: 617 GVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVL 676
Query: 347 KYHTEASTTFIKIQ-VEDVDEPPLFLLPYYV--------------FEVFEETPQGSFVGV 391
T+ FI +Q E DE L Y + +V E P + +
Sbjct: 677 TQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLAR 736
Query: 392 VSATDPD-NRKSPIRYSI---TRSKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKY 446
++ATDPD + Y I F+I + G +T + LD E + +Y L++T +
Sbjct: 737 LAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLG 796
Query: 447 NIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRD 497
++ S L V V + ND+AP F Y+ + E+ G I ++ D D
Sbjct: 797 TPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDAD 848
Score = 97.8 bits (242), Expect = 3e-20
Identities = 108/449 (24%), Positives = 184/449 (40%), Gaps = 37/449 (8%)
Query: 136 IKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGN--NARLLYSLLQG 193
I ++ + D +F + Y A V E + ++ + A GN N L Y LL G
Sbjct: 1956 ISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQ-------GNHLNDTLSYFLLNG 2008
Query: 194 QPYFSVEPTTGVIRISS-KMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDN 252
F + + GV++ DRE QD + + ++ +D G V + + DVNDN
Sbjct: 2009 TDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGL--VRVSIEDVNDN 2066
Query: 253 KPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQ 312
P FK Y + + G + + A D D+G N + Y ED + F I +
Sbjct: 2067 PPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTY-FRI----DPY 2121
Query: 313 EGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLL 372
G + LKK D++ N Y ++ ++ P + S + + V + PLF
Sbjct: 2122 LGDISLKKPFDYQALNKYHLKVIARDGGTP-------SLQSEEEVLVTVRNKSN-PLFQS 2173
Query: 373 PYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSK---VFNIN-DNGTITTSNSL 428
PYY V E + + A P+ + + Y+I + +F + G +T + L
Sbjct: 2174 PYYKVRVPENITLYTPILHTQARSPEGLR--LIYNIVEEEPLMLFTTDFKTGVLTVTGPL 2231
Query: 429 DREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQV 487
D E + ++ AT+ + S + V V ++ND+ P FSQ Y T + E +
Sbjct: 2232 DYESKTKHVFTVRATDT-ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTP 2290
Query: 488 IQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFY 547
+ + A D+D Y VED ++ S N + + Q+ F+
Sbjct: 2291 VIQLLASDQDSGRNRDVSY--QIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQH--FH 2346
Query: 548 ISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+ + D G P LT + ++V D D+
Sbjct: 2347 VKVRAMDKGDPPLTGETLVVVNVSDINDN 2375
Score = 84.0 bits (206), Expect = 5e-16
Identities = 105/487 (21%), Positives = 203/487 (41%), Gaps = 73/487 (14%)
Query: 68 SDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDRE-ERSLYILRAQVIDIATGR 126
+D D+G N + + F ID G I + +D E + +Y R + D +
Sbjct: 483 TDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF 542
Query: 127 AVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARL 186
E E +++ ++NDN+P F + + + P G ++ ++A D D+ + L
Sbjct: 543 RREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN-----L 597
Query: 187 LYSLLQGQP--YFSVEPTTGVIRISS---KMDRELQDEYWVIIQAKD------------- 228
Y ++ G YF + +GVI + + Y + I A D
Sbjct: 598 KYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNIT 657
Query: 229 MIGQP-----------GALSGTTSVLIKL--------SD----------VNDNKPIFKES 259
++ P G L+ T ++ SD +N P F++
Sbjct: 658 VVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDH 717
Query: 260 LYR-LTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITNHETQEGIVI 317
+ + V ES P T + + A D D G N ++ Y I + + + FDI E + G++
Sbjct: 718 FPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI----ELETGLLT 773
Query: 318 LKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED-VDEPPLFLLPYYV 376
+ +D+E N Y + V + P+ ++S + + V+D D P F Y
Sbjct: 774 VAAPLDYEATNFYILNVTVYDLGTPQ-------KSSWKLLTVNVKDWNDNAPRFPPGGYQ 826
Query: 377 FEVFEETPQGSFVGVVSATDPDNR-KSPIRYS-ITRSKVFNIND-NGTITTSNSLDREIS 433
+ E+T G+ + ++ D D+ +RY+ ++ ++ F+++ G + + LDRE
Sbjct: 827 LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESE 886
Query: 434 AWYNLSITATEK--YNIEQISSIPLYVQVLNINDHAPE-FSQYYETYVCENAGSGQVIQT 490
Y L + A ++ + S L + + ++ND++P+ +++ V E+ G V+
Sbjct: 887 PRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF 946
Query: 491 ISAVDRD 497
+ A D D
Sbjct: 947 LDASDPD 953
Score = 83.2 bits (204), Expect = 8e-16
Identities = 111/427 (25%), Positives = 180/427 (42%), Gaps = 46/427 (10%)
Query: 68 SDLDNGNNSFQ-YKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGR 126
SD D NS YK+L A F ID G + + ++D E + V D +
Sbjct: 1790 SDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPV 1849
Query: 127 AVEPE-SEFVIKVSDINDNEPKFLDEPYE-AIVPEMSPEGTLVIQVTASDADDPSSGNNA 184
P ++ +I V D+ND+ P+F ++ YE AIV + P G ++ V ASD D +
Sbjct: 1850 LFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHP-GMELLMVRASDED-------S 1901
Query: 185 RLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSV 242
+ YS+ G ++ P TG I + + L + + I+A D G T V
Sbjct: 1902 EVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK--LTIRASD-----GLYQDTALV 1954
Query: 243 LIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQT 302
I L+ V D F + +Y V E+ ++ + A N + N + Y +
Sbjct: 1955 KISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYFLLNGTDMF 2012
Query: 303 FDIITNHETQEGIVILKKKVDF--EHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ 360
H Q V+ + V F E Q+ + + +V+++ P+++ + +++
Sbjct: 2013 ------HMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRV-------AQGLVRVS 2059
Query: 361 VEDV-DEPPLFL-LPYYVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITRSKVFNIN 417
+EDV D PP F LPYY + + T G + VSATD D + Y +
Sbjct: 2060 IEDVNDNPPKFKHLPYYTI-IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRI 2118
Query: 418 DN--GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYY 474
D G I+ D + Y+L + A + S + V V N ++ P F S YY
Sbjct: 2119 DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSN--PLFQSPYY 2176
Query: 475 ETYVCEN 481
+ V EN
Sbjct: 2177 KVRVPEN 2183
Score = 82.8 bits (203), Expect = 1e-15
Identities = 94/404 (23%), Positives = 176/404 (43%), Gaps = 35/404 (8%)
Query: 105 LDREERSLYILRAQVIDIATGRAVEPES--EFVIKVSDINDNEPKFLDEPYEAIVPEMSP 162
L+RE R Y L Q AT + +E E+ V+ + D ND +P F Y + E P
Sbjct: 107 LNREVRDSYTLIIQ----ATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMP 162
Query: 163 EGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWV 222
+ + +VTA+DAD G NA Y+ F++ PT+GV+ ++ K++ + ++ +
Sbjct: 163 LKSPICKVTATDAD---LGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHEL 219
Query: 223 IIQAKDMIGQ--PGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMA 280
+ A D + + G G+ + L+ + KP S+ + + GT+ T++
Sbjct: 220 QVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASV--VVTPPDSNDGTTYATVLV 277
Query: 281 YDNDIGENAEMDYSIEEDDSQTFDIITNH-ETQEGIVILKKKVDF-EHQNHYGIRAKVKN 338
N G E + D + F I ++ + E ++ K +++ E+ + + + + ++
Sbjct: 278 DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARS 337
Query: 339 HHVP---EQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSAT 395
P Q+ +H S F Y ++ E +P GS V +V T
Sbjct: 338 GSGPYFYSQIRGFHLPPSKL----------SSLKFEKAVYRVQLSEFSPPGSRVVMVRVT 387
Query: 396 DPDNRKSPIRYSITRSKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQISSI 454
+ + + F +N G ITT+ +D A Y L I + +S
Sbjct: 388 PAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQ-----AST 442
Query: 455 PLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVIQTISAVDRD 497
+ + +++ N+HAP F++ Y+ + EN G + ++A DRD
Sbjct: 443 VVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486
Score = 68.6 bits (166), Expect = 2e-11
Identities = 84/323 (26%), Positives = 145/323 (44%), Gaps = 34/323 (10%)
Query: 256 FKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGI 315
F++++YR+ +SE +P G+ + +M N + + + S+ N T G+
Sbjct: 362 FEKAVYRVQLSEFSPPGSRV--VMVRVTPAFPNLQY---VLKPSSENVGFKLNART--GL 414
Query: 316 VILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYY 375
+ K +DF + HY + + P Q AST + V+ + PLF Y
Sbjct: 415 ITTTKLMDFHDRAHYQLHIRTS----PGQ-------ASTVVVIDIVDCNNHAPLFNRSSY 463
Query: 376 VFEVFEETPQGSFVGVVSATDPDNRKSP-IRYSITRSKV--FNINDN-GTITTSNSLDRE 431
+ E P G+ V V+ATD D+ ++ + YSI K F+I+ G I+TS +D E
Sbjct: 464 DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYE 523
Query: 432 I-SAWYNLSITATEKYN-IEQISSIPLYVQVLNINDHAPEFSQYYET-YVCENAGSGQVI 488
+ Y + A++ + + + +++Q+ N+ND+ P F + T + ++ G+ I
Sbjct: 524 LMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSI 583
Query: 489 QTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQE-EPVFY 547
T+SA+D DE NL E + + D + VI R NL +P Y
Sbjct: 584 MTMSAIDVDE-------LQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSY 636
Query: 548 ISILIADNGIPSLTSTNTLTIHV 570
+ A +G + S TL I V
Sbjct: 637 SLKITASDG-KNYASPTTLNITV 658
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 176 bits (447), Expect = 6e-44
Identities = 156/519 (30%), Positives = 245/519 (47%), Gaps = 44/519 (8%)
Query: 74 NNSFQYKLLGAGAGS---TFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEP 130
N + Y+LL GS F ID R+G I +DREE Y L + D GR P
Sbjct: 321 NANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASD--QGRDPGP 378
Query: 131 ESEFV---IKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLL 187
S + V D NDN P+F ++ Y V E G V++VTASD D G+NA +
Sbjct: 379 RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRD---KGSNAVVH 435
Query: 188 YSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIK 245
YS++ G F ++ TG + + S +D E EY + ++A+D G+P + + V ++
Sbjct: 436 YSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDG-GRPPLSNVSGLVTVQ 494
Query: 246 LSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDI 305
+ D+NDN PIF + ++ TV ES P G + + A D D G+NA ++Y + F
Sbjct: 495 VLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLA-GVGHDFPF 553
Query: 306 ITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV- 364
N+ T G + + ++D E + Y + ++H P ++ + + V DV
Sbjct: 554 TINNGT--GWISVAAELDREEVDFYSFGVEARDHGTPAL-------TASASVSVTVLDVN 604
Query: 365 DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSIT------RSKVFNIND 418
D P F P Y + E+ G+ V VSA D D S I Y IT R + + +
Sbjct: 605 DNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAH-SVITYQITSGNTRNRFSITSQSG 663
Query: 419 NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEF-SQYYETY 477
G ++ + LD ++ Y L++TA++ + + + V V + N H P F S +Y
Sbjct: 664 GGLVSLALPLDYKLERQYVLAVTASDGTRQD---TAQIVVNVTDANTHRPVFQSSHYTVN 720
Query: 478 VCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTG 537
V E+ +G + ISA D D YF +ED+ F I + D AV T +
Sbjct: 721 VNEDRPAGTTVVLISATDEDTGENARITYF---MEDSI-PQFRI--DADTGAV--TTQAE 772
Query: 538 FNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDS 576
+ +++ + ++I DNGIP + T L I V D D+
Sbjct: 773 LDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDN 811
Score = 171 bits (433), Expect = 2e-42
Identities = 141/516 (27%), Positives = 238/516 (46%), Gaps = 47/516 (9%)
Query: 69 DLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRA 127
D D G+N+ +Y+L G G F I+ TG I +LDREE Y + D T A
Sbjct: 531 DADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTP-A 589
Query: 128 VEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLL 187
+ + + V D+NDN P F Y + E + GT V+ V+A D D S +
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV-----IT 644
Query: 188 YSLLQGQPY--FSVEPTTG--VIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVL 243
Y + G FS+ +G ++ ++ +D +L+ +Y + + A D G T ++
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-----GTRQDTAQIV 699
Query: 244 IKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTF 303
+ ++D N ++P+F+ S Y + V+E P GT++ I A D D GENA + Y +E+ Q F
Sbjct: 700 VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-F 758
Query: 304 DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVED 363
I + G V + ++D+E Q Y + +++ +P+ ++ TT+++I V D
Sbjct: 759 RI----DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQ-------KSDTTYLEILVND 807
Query: 364 V-DEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNIND---- 418
V D P FL Y V+E+ P + V +SATD D+ + + + D
Sbjct: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVE 867
Query: 419 --NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYE 475
+G + T LDRE A Y L A +K + + + V VL++ND+ P F Q ++
Sbjct: 868 STSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFD 927
Query: 476 TYVCENAGSGQVIQTISAVDRDESIEEHHFY----------FNLSVEDTNNSSFTIIDNQ 525
+V EN+ G + ++A D DE Y F L + ++ +D +
Sbjct: 928 VFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYE 987
Query: 526 DNTA-VILTNRTGFNLQEEPVFYISILIADNGIPSL 560
D V++ T L ++ +L ++ P L
Sbjct: 988 DRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVL 1023
Score = 169 bits (427), Expect = 1e-41
Identities = 141/505 (27%), Positives = 229/505 (45%), Gaps = 36/505 (7%)
Query: 81 LLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSD 140
L + + F +D TG + ++LDRE +S ++ R D R + I V+D
Sbjct: 223 LFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRR-SALATLTILVTD 281
Query: 141 INDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQ-----P 195
ND++P F + Y+ + E G V+ V A+D D P NA +LY LL+G
Sbjct: 282 TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPP---NANILYRLLEGSGGSPSE 338
Query: 196 YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPI 255
F ++P +GVIR +DRE + Y + ++A D PG S T +V + + D NDN P
Sbjct: 339 VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398
Query: 256 FKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGI 315
F E Y + V E G + + A D D G NA + YSI +++ + + Q G
Sbjct: 399 FSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYL---DAQTGA 455
Query: 316 VILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDV-DEPPLFLLPY 374
+ + +D+E Y +R + ++ P + + +QV D+ D P+F+
Sbjct: 456 LDVVSPLDYETTKEYTLRVRAQDGGRPP------LSNVSGLVTVQVLDINDNAPIFVSTP 509
Query: 375 YVFEVFEETPQGSFVGVVSATDP---DNRKSPIRYS-ITRSKVFNIND-NGTITTSNSLD 429
+ V E P G V V A D DN + R + + F IN+ G I+ + LD
Sbjct: 510 FQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELD 569
Query: 430 REISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQ-YYETYVCENAGSGQVI 488
RE +Y+ + A + +S + V VL++ND+ P F+Q Y + E+A G +
Sbjct: 570 REEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSV 629
Query: 489 QTISAVDRDESIEEHHFYFNLSVEDTN-NSSFTIIDNQDNTAVILTNRTGFNLQEEPVFY 547
T+SAVDRD H + N + F+I V L + L+ + Y
Sbjct: 630 VTVSAVDRDA-----HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQ---Y 681
Query: 548 ISILIADNGIPSLTSTNTLTIHVCD 572
+ + A +G + T + ++V D
Sbjct: 682 VLAVTASDG--TRQDTAQIVVNVTD 704
Score = 135 bits (339), Expect = 2e-31
Identities = 117/450 (26%), Positives = 212/450 (47%), Gaps = 31/450 (6%)
Query: 146 PKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSL-----LQGQPYFSVE 200
P+F Y+A VPE P GT V + A D D+ +G RL Y++ + +FS++
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAG---RLEYTMDALFDSRSNQFFSLD 235
Query: 201 PTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESL 260
P TG + + ++DRE + + + A+D G P S ++ I ++D ND+ P+F++
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDH-GMP-RRSALATLTILVTDTNDHDPVFEQQE 293
Query: 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKK 320
Y+ ++ E+ G + T+ A D D NA + Y + E + + + + G++ +
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 321 KVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVE-DVDEPPLFLLPYYVFEV 379
VD E Y + + +Q ++T + + VE D D P F YV +V
Sbjct: 354 PVDREEVESYQLTVEAS-----DQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 380 FEETPQGSFVGVVSATDPD-NRKSPIRYSI----TRSKVFNINDNGTITTSNSLDREISA 434
E+ G+ V V+A+D D + + YSI R + + G + + LD E +
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468
Query: 435 WYNLSITATE--KYNIEQISSIPLYVQVLNINDHAPEF-SQYYETYVCENAGSGQVIQTI 491
Y L + A + + + +S + + VQVL+IND+AP F S ++ V E+ G ++ +
Sbjct: 469 EYTLRVRAQDGGRPPLSNVSGL-VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHV 527
Query: 492 SAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISIL 551
A+D D Y V ++ FTI +N ++ + +E + +
Sbjct: 528 QAIDADAGDNARLEYRLAGV--GHDFPFTI----NNGTGWISVAAELDREEVDFYSFGVE 581
Query: 552 IADNGIPSLTSTNTLTIHVCDCGDSGSTQT 581
D+G P+LT++ ++++ V D D+ T T
Sbjct: 582 ARDHGTPALTASASVSVTVLDVNDNNPTFT 611
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/204 (26%), Positives = 88/204 (43%), Gaps = 14/204 (6%)
Query: 363 DVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDN--- 419
+V+ P F P Y V E P G+ V + A DPD ++ R T +F+ N
Sbjct: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAG-RLEYTMDALFDSRSNQFF 232
Query: 420 ------GTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQY 473
G +TT+ LDRE + + +TA + + + L + V + NDH P F Q
Sbjct: 233 SLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQ 292
Query: 474 -YETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVIL 532
Y+ + EN G + T+ A D D + Y L E + S + + + VI
Sbjct: 293 EYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLL--EGSGGSPSEVFEIDPRSGVIR 350
Query: 533 TNRTGFNLQEEPVFYISILIADNG 556
T R + +E + +++ +D G
Sbjct: 351 T-RGPVDREEVESYQLTVEASDQG 373
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,421,698
Number of Sequences: 37866
Number of extensions: 1214287
Number of successful extensions: 8175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2916
Number of HSP's gapped (non-prelim): 800
length of query: 772
length of database: 18,247,518
effective HSP length: 110
effective length of query: 662
effective length of database: 14,082,258
effective search space: 9322454796
effective search space used: 9322454796
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.