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Search of human proteins with 126032348
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126032348 hect domain and RLD 2 [Homo sapiens]
(4834 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126032348 hect domain and RLD 2 [Homo sapiens] 9686 0.0
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 682 0.0
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 637 0.0
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 636 0.0
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 629 e-179
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 188 1e-46
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 188 1e-46
gi|157738609 HECT domain containing 3 [Homo sapiens] 186 4e-46
gi|7657152 hect domain and RLD 3 [Homo sapiens] 178 1e-43
gi|239745529 PREDICTED: hypothetical protein XP_002343479 [Homo ... 171 2e-41
gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens] 162 6e-39
gi|61563742 hect domain and RLD 6 [Homo sapiens] 154 2e-36
gi|4557445 regulator of chromosome condensation and BTB domain c... 151 2e-35
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 150 3e-35
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 145 9e-34
gi|110825982 hect domain and RLD 5 [Homo sapiens] 144 2e-33
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 140 4e-32
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 138 1e-31
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 134 2e-30
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 134 2e-30
gi|6912330 deafness locus associated putative guanine nucleotide... 134 2e-30
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 133 5e-30
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 131 1e-29
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 130 2e-29
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 130 2e-29
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 129 7e-29
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 129 7e-29
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 128 1e-28
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 128 1e-28
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 127 2e-28
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 9686 bits (25136), Expect = 0.0
Identities = 4834/4834 (100%), Positives = 4834/4834 (100%)
Query: 1 MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPP 60
MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPP
Sbjct: 1 MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPP 60
Query: 61 RKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLV 120
RKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLV
Sbjct: 61 RKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLV 120
Query: 121 KEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSGISLPPVDKK 180
KEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSGISLPPVDKK
Sbjct: 121 KEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSGISLPPVDKK 180
Query: 181 SSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASL 240
SSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASL
Sbjct: 181 SSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASL 240
Query: 241 FDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQR 300
FDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQR
Sbjct: 241 FDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQR 300
Query: 301 GTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICRKDAPHSEGDM 360
GTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICRKDAPHSEGDM
Sbjct: 301 GTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICRKDAPHSEGDM 360
Query: 361 HLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKG 420
HLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKG
Sbjct: 361 HLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKG 420
Query: 421 SLQEVIGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD 480
SLQEVIGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD
Sbjct: 421 SLQEVIGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD 480
Query: 481 TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV 540
TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV
Sbjct: 481 TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV 540
Query: 541 ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL 600
ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL
Sbjct: 541 ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL 600
Query: 601 KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV 660
KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV
Sbjct: 601 KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV 660
Query: 661 KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 720
KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH
Sbjct: 661 KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH 720
Query: 721 CLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCS 780
CLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCS
Sbjct: 721 CLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCS 780
Query: 781 EWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQL 840
EWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQL
Sbjct: 781 EWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQL 840
Query: 841 HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT 900
HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT
Sbjct: 841 HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT 900
Query: 901 AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE 960
AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE
Sbjct: 901 AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE 960
Query: 961 AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA 1020
AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA
Sbjct: 961 AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA 1020
Query: 1021 SQTVARLKDVARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSP 1080
SQTVARLKDVARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSP
Sbjct: 1021 SQTVARLKDVARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSP 1080
Query: 1081 ELMGVGSLLKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVS 1140
ELMGVGSLLKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVS
Sbjct: 1081 ELMGVGSLLKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVS 1140
Query: 1141 IVLLLSKNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQN 1200
IVLLLSKNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQN
Sbjct: 1141 IVLLLSKNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQN 1200
Query: 1201 CRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVA 1260
CRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVA
Sbjct: 1201 CRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVA 1260
Query: 1261 LEAALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYL 1320
LEAALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYL
Sbjct: 1261 LEAALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYL 1320
Query: 1321 AMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLCSH 1380
AMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLCSH
Sbjct: 1321 AMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLCSH 1380
Query: 1381 RRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEVGRLL 1440
RRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEVGRLL
Sbjct: 1381 RRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEVGRLL 1440
Query: 1441 LCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGR 1500
LCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGR
Sbjct: 1441 LCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGR 1500
Query: 1501 SYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRERRKKRVP 1560
SYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRERRKKRVP
Sbjct: 1501 SYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRERRKKRVP 1560
Query: 1561 KKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHKYK 1620
KKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHKYK
Sbjct: 1561 KKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHKYK 1620
Query: 1621 WLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAS 1680
WLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAS
Sbjct: 1621 WLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAS 1680
Query: 1681 KNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRMLLEVTFGKLYAWAV 1740
KNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRMLLEVTFGKLYAWAV
Sbjct: 1681 KNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRMLLEVTFGKLYAWAV 1740
Query: 1741 QNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQARFLLVMLSMLTLQHGAN 1800
QNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQARFLLVMLSMLTLQHGAN
Sbjct: 1741 QNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQARFLLVMLSMLTLQHGAN 1800
Query: 1801 NLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSG 1860
NLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSG
Sbjct: 1801 NLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSG 1860
Query: 1861 PELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGK 1920
PELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGK
Sbjct: 1861 PELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGK 1920
Query: 1921 EGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGV 1980
EGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGV
Sbjct: 1921 EGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGV 1980
Query: 1981 HAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIALTPQVC 2040
HAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIALTPQVC
Sbjct: 1981 HAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIALTPQVC 2040
Query: 2041 GALSSPQWITLLMKVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKL 2100
GALSSPQWITLLMKVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKL
Sbjct: 2041 GALSSPQWITLLMKVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKL 2100
Query: 2101 FDFLGSLLTTCSSDVPLLRESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWN 2160
FDFLGSLLTTCSSDVPLLRESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWN
Sbjct: 2101 FDFLGSLLTTCSSDVPLLRESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWN 2160
Query: 2161 GLINKYINSQLRSITHSFVGRPSEGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLG 2220
GLINKYINSQLRSITHSFVGRPSEGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLG
Sbjct: 2161 GLINKYINSQLRSITHSFVGRPSEGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLG 2220
Query: 2221 GQVMHDEFGEGTVTRITPKGKITVQFSDMRTCRVCPLNQLKPLPAVAFNVNNLPFTEPML 2280
GQVMHDEFGEGTVTRITPKGKITVQFSDMRTCRVCPLNQLKPLPAVAFNVNNLPFTEPML
Sbjct: 2221 GQVMHDEFGEGTVTRITPKGKITVQFSDMRTCRVCPLNQLKPLPAVAFNVNNLPFTEPML 2280
Query: 2281 SVWAQLVNLAGSKLEKHKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLR 2340
SVWAQLVNLAGSKLEKHKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLR
Sbjct: 2281 SVWAQLVNLAGSKLEKHKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLR 2340
Query: 2341 QILSQPAVQETGTVHTDDGAVVSPDLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDK 2400
QILSQPAVQETGTVHTDDGAVVSPDLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDK
Sbjct: 2341 QILSQPAVQETGTVHTDDGAVVSPDLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDK 2400
Query: 2401 QELEAAALAVCQCLAVESTHPSSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALP 2460
QELEAAALAVCQCLAVESTHPSSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALP
Sbjct: 2401 QELEAAALAVCQCLAVESTHPSSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALP 2460
Query: 2461 IVVQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVS 2520
IVVQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVS
Sbjct: 2461 IVVQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVS 2520
Query: 2521 DEYSDEEVVEDVDDAAYSMSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCC 2580
DEYSDEEVVEDVDDAAYSMSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCC
Sbjct: 2521 DEYSDEEVVEDVDDAAYSMSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCC 2580
Query: 2581 RAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIK 2640
RAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIK
Sbjct: 2581 RAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIK 2640
Query: 2641 IGDKVRVKASVTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVP 2700
IGDKVRVKASVTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVP
Sbjct: 2641 IGDKVRVKASVTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVP 2700
Query: 2701 SIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFC 2760
SIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFC
Sbjct: 2701 SIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFC 2760
Query: 2761 GRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWI 2820
GRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWI
Sbjct: 2761 GRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWI 2820
Query: 2821 RLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLND 2880
RLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLND
Sbjct: 2821 RLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLND 2880
Query: 2881 CTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNS 2940
CTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNS
Sbjct: 2881 CTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNS 2940
Query: 2941 GSLIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGG 3000
GSLIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGG
Sbjct: 2941 GSLIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGG 3000
Query: 3001 SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT
Sbjct: 3001 SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
Query: 3061 ALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGEL 3120
ALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGEL
Sbjct: 3061 ALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGEL 3120
Query: 3121 YTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180
YTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG
Sbjct: 3121 YTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180
Query: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240
DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG
Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240
Query: 3241 SDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKP 3300
SDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKP
Sbjct: 3241 SDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKP 3300
Query: 3301 TLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADS 3360
TLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADS
Sbjct: 3301 TLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADS 3360
Query: 3361 SAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA 3420
SAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA
Sbjct: 3361 SAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA 3420
Query: 3421 AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVT 3480
AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVT
Sbjct: 3421 AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVT 3480
Query: 3481 PSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSL 3540
PSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSL
Sbjct: 3481 PSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSL 3540
Query: 3541 LIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVAT 3600
LIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVAT
Sbjct: 3541 LIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVAT 3600
Query: 3601 DSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDG 3660
DSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDG
Sbjct: 3601 DSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDG 3660
Query: 3661 VNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLS 3720
VNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLS
Sbjct: 3661 VNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLS 3720
Query: 3721 DRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRK 3780
DRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRK
Sbjct: 3721 DRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRK 3780
Query: 3781 LLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQ 3840
LLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQ
Sbjct: 3781 LLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQ 3840
Query: 3841 LLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDE 3900
LLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDE
Sbjct: 3841 LLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDE 3900
Query: 3901 VAKKIRELMADSENMDVLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHN 3960
VAKKIRELMADSENMDVLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHN
Sbjct: 3901 VAKKIRELMADSENMDVLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHN 3960
Query: 3961 HRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIG 4020
HRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIG
Sbjct: 3961 HRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIG 4020
Query: 4021 GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD 4080
GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD
Sbjct: 4021 GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD 4080
Query: 4081 RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEAL 4140
RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEAL
Sbjct: 4081 RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEAL 4140
Query: 4141 QGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV 4200
QGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV
Sbjct: 4141 QGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV 4200
Query: 4201 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4260
KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH
Sbjct: 4201 KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH 4260
Query: 4261 CVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK 4320
CVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK
Sbjct: 4261 CVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK 4320
Query: 4321 PASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGP 4380
PASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGP
Sbjct: 4321 PASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGP 4380
Query: 4381 SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGT 4440
SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGT
Sbjct: 4381 SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGT 4440
Query: 4441 KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPL 4500
KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPL
Sbjct: 4441 KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPL 4500
Query: 4501 LIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWK 4560
LIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWK
Sbjct: 4501 LIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWK 4560
Query: 4561 QLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHT 4620
QLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHT
Sbjct: 4561 QLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHT 4620
Query: 4621 HITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDI 4680
HITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDI
Sbjct: 4621 HITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDI 4680
Query: 4681 PLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD 4740
PLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD
Sbjct: 4681 PLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD 4740
Query: 4741 FVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIA 4800
FVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIA
Sbjct: 4741 FVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIA 4800
Query: 4801 LTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH 4834
LTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH
Sbjct: 4801 LTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH 4834
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 682 bits (1760), Expect = 0.0
Identities = 404/1025 (39%), Positives = 570/1025 (55%), Gaps = 70/1025 (6%)
Query: 3813 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC-------- 3864
+ A ++ LP LQ Q+ YE P V G QL+HSP+ + L +LA L LD L C
Sbjct: 3850 MRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHH 3909
Query: 3865 --CA------ETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMD 3916
C ++WAW + + A AL P F + +L E+
Sbjct: 3910 QNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFT------VPDLEPVPEDEL 3963
Query: 3917 VLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVP 3976
V + + DEQ++ W RP+DW L GG +Y WG GQL G V VP
Sbjct: 3964 VFLMDNSKWINGMDEQIMSWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVP 4020
Query: 3977 TPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQH 4036
+ + + Q+I G+ F + A+G + A G G+ GRLG G ++ + T++ ++Q
Sbjct: 4021 AAAPSFSQAQ--QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQG 4078
Query: 4037 VFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVD 4095
+ ++ + G H +AL+ GEV+SWG+ + GKLGHGN RPR IE+L+G EVV
Sbjct: 4079 FVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQ 4138
Query: 4096 VAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDA 4155
++ G HSA VT+ G L+T+G G YGRLG ++ ++ P+ V AL+G+++ +ACG
Sbjct: 4139 MSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN-- 4196
Query: 4156 QTLCLTDDDT-VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214
TL ++ D + VW++GDGDYGKLG G S P KID L G+G+ KV CG+QFSVALTK
Sbjct: 4197 HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTK 4256
Query: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
G VYT+G+ L G + RP+Q+ L G + +A G+ H + +G+VY WG
Sbjct: 4257 DGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG 4316
Query: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS----------TSKPASA 4324
N EGQLG G TN ++ P LV LQGK V +++ G H+ AW+ S P
Sbjct: 4317 SNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQL 4376
Query: 4325 GKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDL----EGSLDETGLGP 4380
G LP VP +Y L+E+ I +R RL LL+H S+L + +L + S G
Sbjct: 4377 G-LPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGT 4435
Query: 4381 -SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDG 4439
+ LR +L + + + TMV+ + +GP + + RI + +
Sbjct: 4436 WGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRK---------- 4485
Query: 4440 TKSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTP 4499
K +F Q+ ++ L LP R WKVK VGE DD GG + ++I E+C+EL+ G+
Sbjct: 4486 CKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVD 4545
Query: 4500 LLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVW 4559
LLI +PN E G NRD +L +P+A H F+FLG+L+G+AIRT PL L+LA VW
Sbjct: 4546 LLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW 4605
Query: 4560 KQLAGMSLTIADLSEVDKDFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDI 4613
KQL + LT+ DL EVD ++ +++I D+ T E F M +P F SA G+ +
Sbjct: 4606 KQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMV 4664
Query: 4614 QL--SSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELE 4671
+ +T NR EYV AI YRLHE D QVAAVREGM+ +VPVPLLSL T +LE
Sbjct: 4665 PIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLE 4724
Query: 4672 TMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPR 4731
MVCG P+I + +LK V Y+ ++ L+QWFW +E FSN ER LF+RFV GR+RLP
Sbjct: 4725 QMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPA 4784
Query: 4732 TIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSI 4791
AD R F I +D+ P LP S TCFF L+LP YS + V+ E+L+YAI+ C+SI
Sbjct: 4785 NTADISQR-FQIMKVDR---PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSI 4840
Query: 4792 DTDDY 4796
D D+Y
Sbjct: 4841 DMDNY 4845
Score = 277 bits (708), Expect = 2e-73
Identities = 160/382 (41%), Positives = 227/382 (59%), Gaps = 10/382 (2%)
Query: 2961 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEAT 3020
V++WG QL G + VP+ + + S QV G F + G V ACGE +
Sbjct: 3999 VYLWGAGRHGQLAEA-GRNVMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTVLACGEGS 4055
Query: 3021 NGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKL 3079
GRLG G +S + + I+AL +VV ++ G H+ ALT G+VFSWG+GD GKL
Sbjct: 4056 YGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKL 4114
Query: 3080 GHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQ 3139
GH + +PR IEAL+ + + ++CG HSA +TS G+L+T+G G+YGRLG G+ + +
Sbjct: 4115 GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 4174
Query: 3140 LKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSWGDGDFGKLGRGGSEGCNIPQN 3198
P+ V L G+++ QVACG TLA++ +G +V+++GDGD+GKLG G S + PQ
Sbjct: 4175 KLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQK 4232
Query: 3199 IERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK 3258
I+ L G G+ ++ CG QFS+ALTK G V+T+G+ L G + +PQ + L G
Sbjct: 4233 IDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVI 4292
Query: 3259 IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGS 3318
I VAVGA H LA+ +G VYAWG N GQ G G T R+PTLV GL+G+ + +++ G
Sbjct: 4293 IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGR 4352
Query: 3319 SHSVAWTT--VDVATPSVHEPV 3338
HS AWT V P V P+
Sbjct: 4353 CHSAAWTAPPVPPRAPGVSVPL 4374
Score = 268 bits (686), Expect = 7e-71
Identities = 233/720 (32%), Positives = 352/720 (48%), Gaps = 84/720 (11%)
Query: 493 RNIVKIAAH--SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 550
R+I K+++ SDGH LA GEV+SWG GD G+LGHG++ + PK+I G G
Sbjct: 455 RSIKKVSSSKGSDGHT-LAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQ---GPLQG 510
Query: 551 KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVAC 610
K VV ++ G +SAA+T +GELYTWG G++GRLGHG S IP LV + V +V+C
Sbjct: 511 KVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVSC 568
Query: 611 GSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
GS + T+A++++G+ VWS+G GD GKLG G ++ PK+IE LQ + + KV GSQ S
Sbjct: 569 GS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626
Query: 670 IALTKDGQVYSWGKGDNQRLGHGTEEHVRY-PKLLEGLQGKKVIDVAAGSTHCLALTEDS 728
+ALT GQVY+WG G LG G+ E PKL+E L +++DV+ G +HCLAL+ D+
Sbjct: 627 LALTSTGQVYAWGCG--ACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
Query: 729 EVHSWGSND--QC-QHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSC--SEWS 783
EV++WG+N QC Q T +TKP+ + GLD I I+ G + S AW++
Sbjct: 685 EVYAWGNNSMGQCGQGNSTGPITKPKKVS--GLDGIAIQQISAGTSHSLAWTALPRDRQV 742
Query: 784 IGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGS---ADWPPPQEKECVAVATLNLLRLQL 840
+ P+ VD+ TF L L + + ++ +P +E L LL L
Sbjct: 743 VAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHL 802
Query: 841 HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT 900
A++ V LG G L+ + L S V +Q L G ++LLP
Sbjct: 803 ALALAGGVATSILGRQAG-----PLRNLLFRLMDST-VPDEIQEVVIETLSVGATMLLPP 856
Query: 901 AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE 960
ER L +LLP E ++S G+R +D+++ SL + S L + ++ D+
Sbjct: 857 LRERMELLHSLLPQGPDRWE-SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLS 915
Query: 961 AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA 1020
+ + +Q + H +T + E L++ LLRN+
Sbjct: 916 S--VCTGYGNLSDQPYGTQSCHP----------DTHLAEI----------LMKTLLRNLG 953
Query: 1021 SQTVARLKDVARRISS-CLDFEQHSRERSASL-DLLLRFQRLLISKLYPGESIGQTSDIS 1078
T ++ + L + A L +LL Q+ L++ + I S+ S
Sbjct: 954 FYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCH----INNISENS 1009
Query: 1079 SPELMGVGSLLKKYTALLCTHIGDILPVAASIASTS-W-----RHFAEVAYIVEGDFTGV 1132
S +LL K+ LL H DI +A++ S W +V Y+ G
Sbjct: 1010 SSV-----ALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYV---SAAGS 1061
Query: 1133 LLPELVVSIVLLLSKNAGLMQEAGAVPLLGGLLE---HLDRFNHLAPGKERDDHEELAWP 1189
+L ++V S++LL + A PLL LL+ LD N L P + + +EL WP
Sbjct: 1062 MLCQIVNSLLLL--------PVSVARPLLSYLLDLLPPLDCLNRLLPAADLLEDQELQWP 1113
Score = 264 bits (674), Expect = 2e-69
Identities = 151/369 (40%), Positives = 222/369 (60%), Gaps = 13/369 (3%)
Query: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4013
+Y WG N QL +EG + K+ P A + + G+ F ++ DG + A G G+
Sbjct: 374 VYVWGSNSSHQL--VEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGS 431
Query: 4014 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLG 4072
GRLG+G + + ST L H IKKV+ + G H LA ++EGEV+SWG+ + GKLG
Sbjct: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
Query: 4073 HGNRSPCDRPRVIES-LRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQ 4131
HGN S P++I+ L+G VV V+AG HSA VT G+LYTWG+G +GRLGH DS +
Sbjct: 492 HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSR 551
Query: 4132 LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDD-TVWSWGDGDYGKLGRGGSDGCKVPMK 4190
P LV+ + V +++CGS + T+ L+ D TVWS+G GD GKLG G ++ P
Sbjct: 552 NIPTLVKDISN--VGEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607
Query: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVR-RPRQVQGLQGK 4249
I++L G+ + KV GSQ S+ALT +G VY WG G LG GS + RP+ ++ L
Sbjct: 608 IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAAT 665
Query: 4250 KVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG-TTNAIQRPRLVAALQGKKVNRVAC 4308
+++ ++ G HC+ + D EVY WG+N GQ G G +T I +P+ V+ L G + +++
Sbjct: 666 RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISA 725
Query: 4309 GSAHTLAWS 4317
G++H+LAW+
Sbjct: 726 GTSHSLAWT 734
Score = 254 bits (650), Expect = 1e-66
Identities = 149/372 (40%), Positives = 221/372 (59%), Gaps = 12/372 (3%)
Query: 2960 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019
+V+VWG N QL KI P + + S ++ G F ++ +G V ACG+
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGKG 430
Query: 3020 TNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGK 3078
+ GRLGLG S+ + +++T +KKV+ G H A T +G+VFSWG+GD GK
Sbjct: 431 SYGRLGLGDSNNQSTL-KKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGK 489
Query: 3079 LGHFSRMNCDKPRLIEA-LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3137
LGH + P+LI+ L+ K + ++ G HSAA+T GELYTWG G++GRLGHGD+
Sbjct: 490 LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
Query: 3138 TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSWGDGDFGKLGRGGSEGCNIP 3196
++ P +VK + V +V+CGS + T+AL+ +G V+S+G GD GKLG G + P
Sbjct: 550 SRNIPTLVKDI--SNVGEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKP 605
Query: 3197 QNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRG 3256
+ IE L G + ++ G+Q SLALT +G V+ WG G G S+ +P+++E L
Sbjct: 606 KVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAA 664
Query: 3257 KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTT-VNRKPTLVQGLEGQKITRVA 3315
+IV V++G HCLA++ +VYAWG+N GQ G G +T KP V GL+G I +++
Sbjct: 665 TRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQIS 724
Query: 3316 CGSSHSVAWTTV 3327
G+SHS+AWT +
Sbjct: 725 AGTSHSLAWTAL 736
Score = 215 bits (547), Expect = 1e-54
Identities = 130/342 (38%), Positives = 195/342 (57%), Gaps = 30/342 (8%)
Query: 455 QIACAEKRFLILSRNGRVYTQAY---------NSDTLAPQLV----QGLASRNIVKIAAH 501
Q+ C + ++ NG V NSD L V QG +V +
Sbjct: 4031 QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVT-SCG 4089
Query: 502 SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGST 561
SDGH +AL +GEV+SWG GD G+LGHG++ P+ I A G++ VV ++CG
Sbjct: 4090 SDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGFK 4144
Query: 562 YSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVT 621
+SA +T++G+L+T+G G+YGRLG G++ ++ +P V L+G ++ VACG TLAV+
Sbjct: 4145 HSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVS 4202
Query: 622 ENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYS 680
+G VW++GDGDYGKLG G S +P+ I+ L + + KV CG+QFS+ALTKDG VY+
Sbjct: 4203 ADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYT 4262
Query: 681 WGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
+G+ L G + P+ + L G + DVA G+ H LAL + +V++WGSN + Q
Sbjct: 4263 FGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQ 4322
Query: 741 ----HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
H + +R EP + GL K++ I+ G S AW++
Sbjct: 4323 LGLGHTNHVR----EPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
Score = 164 bits (414), Expect = 3e-39
Identities = 124/385 (32%), Positives = 179/385 (46%), Gaps = 36/385 (9%)
Query: 4054 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113
+S EVY WG +L G + +P++ S + ++ AG + ++ G +
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIE--AGQYCTFVISTDGSVR 425
Query: 4114 TWGKGRYGRLGHSDSEDQ--LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGD 4171
GKG YGRLG DS +Q LK E + + V + GS D TL T + V+SWGD
Sbjct: 426 ACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGS-DGHTLAFTTEGEVFSWGD 484
Query: 4172 GDYGKLGRGGSDGCKVPMKIDS-LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230
GDYGKLG G S K P I L G VV V G + S A+T+ G +YTWG+GD+ RLG
Sbjct: 485 GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
Query: 4231 HGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGE-VYTWGDNDEGQLGDGTTNAI 4289
HG + P V+ + V ++ GS H + ++DG V+++G D G+LG G TN +
Sbjct: 545 HGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRV 602
Query: 4290 QRPRLVAALQGKKVNRVACGSAHTL---------AWSTSKPASAGKLPAQV--PMEYNHL 4338
+P+++ ALQG + +V GS +L AW G A P L
Sbjct: 603 YKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEEL 662
Query: 4339 QEIPIIALR---NRLLLLHHLSELFCPCIPMFDLEGSLDETGLGPSVGFDT-------LR 4388
I+ + + L L H +E++ S+ + G G S G T L
Sbjct: 663 AATRIVDVSIGDSHCLALSHDNEVYAWG------NNSMGQCGQGNSTGPITKPKKVSGLD 716
Query: 4389 GILISQGKEAAFRKVVQATMVRDRQ 4413
GI I Q + + RDRQ
Sbjct: 717 GIAIQQISAGTSHSLAWTALPRDRQ 741
Score = 162 bits (411), Expect = 6e-39
Identities = 123/402 (30%), Positives = 191/402 (47%), Gaps = 56/402 (13%)
Query: 393 AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 452
++ V HLD+L C PP+ P H+ L + W W + ++C
Sbjct: 3889 SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 3931
Query: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIVKIA 499
T I AE NG + +++ L P + + G+ + +
Sbjct: 3932 -TTIKAAEAL-----TNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 3985
Query: 500 AHSDGHHYLALAATGEVYSWGCGDGGRL---GHGDTVPLEEPKVISAFSGKQAGKHVVHI 556
+ + H L +VY WG G G+L G VP P +FS Q +
Sbjct: 3986 SRPEDWH---LGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAP----SFSQAQ------QV 4032
Query: 557 ACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGD 614
CG + I A G + G G+YGRLG G+S+D + +++ L+G V + +CGS D
Sbjct: 4033 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-D 4091
Query: 615 AQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTK 674
++A+TE+G+V+SWGDGDYGKLG G SD + P+ IE LQ +VV++ CG + S +T
Sbjct: 4092 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
Query: 675 DGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSW 733
DG+++++G GD RLG G + + P+ + L+G ++ VA G H LA++ D S V ++
Sbjct: 4152 DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211
Query: 734 GSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFA 775
G D + K P + L I +ACG S A
Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVA 4253
Score = 160 bits (404), Expect = 4e-38
Identities = 109/340 (32%), Positives = 172/340 (50%), Gaps = 24/340 (7%)
Query: 3909 MADSENMDVLH----ESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQ 3964
+ DS N L E H K+ ++ D TL+ G ++ WG G+
Sbjct: 437 LGDSNNQSTLKKLTFEPHRSIKKVSS-------SKGSDGHTLAFTTEGEVFSWGDGDYGK 489
Query: 3965 LGGIEGAKVKVPTPCEALATLRPVQLI-GGEQTLFAVTADGKLYATGYGAGGRLGIGGTE 4023
LG + K P + + V + G + AVT DG+LY G G GRLG G +
Sbjct: 490 LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
Query: 4024 SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGE-VYSWGEAEDGKLGHGNRSPCDRP 4082
S + PTL++ I +V V+ G H +ALS +G V+S+G ++GKLGHG+ + +P
Sbjct: 550 SRNIPTLVKDISNV----GEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKP 605
Query: 4083 RVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQG 4142
+VIE+L+G+ + V AG S +T+ G +Y WG G G S++ L+PKL+E L
Sbjct: 606 KVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEA-TALRPKLIEELAA 664
Query: 4143 HRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDG-CKVPMKIDSLTGLGVVK 4201
R+VD++ GD+ L L+ D+ V++WG+ G+ G+G S G P K+ L G+ + +
Sbjct: 665 TRIVDVSI--GDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQ 722
Query: 4202 VECGSQFSV---ALTKSGAVYTWGKGDYHRLGHGSDDHVR 4238
+ G+ S+ AL + V W + L + H+R
Sbjct: 723 ISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLR 762
Score = 154 bits (389), Expect = 2e-36
Identities = 102/285 (35%), Positives = 148/285 (51%), Gaps = 20/285 (7%)
Query: 510 LAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAE 569
++ T EVY WG +L G + +PK+ +FS Q I G + I+ +
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT------IEAGQYCTFVISTD 421
Query: 570 GELYTWGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVW 627
G + G+G+YGRLG G S +++ + + +K + + GS D TLA T G+V+
Sbjct: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGS-DGHTLAFTTEGEVF 480
Query: 628 SWGDGDYGKLGRGGSDGCKTPKLIE-KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN 686
SWGDGDYGKLG G S K PKLI+ LQ VV V G + S A+T+DG++Y+WG+GD
Sbjct: 481 SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540
Query: 687 QRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEV---HSWGSNDQCQHFD 743
RLGHG P L++ + V +V+ GS+H +AL++D G N + H D
Sbjct: 541 GRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGD 598
Query: 744 TLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE---WSIG 785
T RV KP+ + L I + G S A +S + W G
Sbjct: 599 TNRVYKPK--VIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG 641
Score = 153 bits (386), Expect = 5e-36
Identities = 105/280 (37%), Positives = 148/280 (52%), Gaps = 13/280 (4%)
Query: 2946 KKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSE-TLSALNVVQVAGGSKSL 3004
K + G A T +VF WG D +LG S K P + L VV V+ G +
Sbjct: 464 KGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
Query: 3005 FAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTV 3064
AVT +G++Y GE GRLG G S+ R I L + V G H AL+
Sbjct: 524 AAVTEDGELYTWGEGDFGRLGHGDSNS-----RNIPTLVKDISNVGEVSCGSSHTIALSK 578
Query: 3065 DGK-VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTW 3123
DG+ V+S+G GD+GKLGH KP++IEAL+ IR + GS S ALTS+G++Y W
Sbjct: 579 DGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
Query: 3124 GLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182
G G LG G + T L+PK+++ L R++ V+ G D+ LAL+ + V++WG+
Sbjct: 639 GCG--ACLGCGSSEATALRPKLIEELAATRIVDVSIG--DSHCLALSHDNEVYAWGNNSM 694
Query: 3183 GKLGRGGSEG-CNIPQNIERLNGQGVCQIECGAQFSLALT 3221
G+ G+G S G P+ + L+G + QI G SLA T
Sbjct: 695 GQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
Score = 141 bits (356), Expect = 1e-32
Identities = 91/259 (35%), Positives = 126/259 (48%), Gaps = 53/259 (20%)
Query: 3119 ELYTWGLG-------------------------------------------------EYG 3129
++Y WG G YG
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYG 4057
Query: 3130 RLGHGDNTTQLKPKMVKVLLGHRVIQV--ACGSRDAQTLALTDEGLVFSWGDGDFGKLGR 3187
RLG G++ ++ L G V Q+ +CGS D ++ALT+ G VFSWGDGD+GKLG
Sbjct: 4058 RLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-DGHSMALTESGEVFSWGDGDYGKLGH 4116
Query: 3188 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK 3247
G S+ P+ IE L G+ V Q+ CG + S +T G ++T+G GDY RLG G+ + +
Sbjct: 4117 GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL 4176
Query: 3248 PQVVEGLRGKKIVHVAVGALHCLAVT-DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306
P+ V L G +I VA G H LAV+ D V+A+GD D+G+ G G +T P + L
Sbjct: 4177 PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVL 4236
Query: 3307 EGQKITRVACGSSHSVAWT 3325
G I +VACG+ SVA T
Sbjct: 4237 CGIGIKKVACGTQFSVALT 4255
Score = 139 bits (350), Expect = 7e-32
Identities = 96/273 (35%), Positives = 136/273 (49%), Gaps = 6/273 (2%)
Query: 2950 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3009
G A T +VF WG D +LG + + P E L VVQ++ G K VT
Sbjct: 4092 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
Query: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 3068
+GK++ G GRLGLG +S +P ++TAL Y + +VA G H A++ DG V
Sbjct: 4152 DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 4208
Query: 3069 FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128
+++G+GD GKLG + P+ I+ L I+ +ACG+ S ALT G +YT+G
Sbjct: 4209 WAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 4268
Query: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
L G +P+ + VL G + VA G+ TLAL G V++WG G+LG G
Sbjct: 4269 IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAE--HTLALASNGDVYAWGSNSEGQLGLG 4326
Query: 3189 GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221
+ P + L G+ V QI G S A T
Sbjct: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
Score = 82.8 bits (203), Expect = 8e-15
Identities = 78/308 (25%), Positives = 133/308 (43%), Gaps = 58/308 (18%)
Query: 14 LDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPPRKDDSVEPSGTKK 73
L+S W+ D + TR+G+ L++++V + E+V P + G +
Sbjct: 16 LNSSWITEDSESIATREGVAVLYSKLVSNKEVV-------------PLPQQVLCLKGPQL 62
Query: 74 EDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLVKEQQALAVQSATT 133
D + +E+ L L+ Q ALA +
Sbjct: 63 PDFERESLSSDEQD--------------------------HYLDALLSSQLALAKMVCSD 96
Query: 134 TLSALRLKQRLVILERYFIALNRTVFQENVKVKWKS----SGISLPPVDKKSSRPAGKGV 189
+ A L++RL++L+R F AL+ + + KVK + S V S RP
Sbjct: 97 SPFAGALRKRLLVLQRVFYALSNK-YHDKGKVKQQQHSPESSSGSADVHSVSERPRSS-T 154
Query: 190 EGLARVGSRAALSFAFAFLRRAWR---SGEDADLCSELLQESLDALRALPEASLFDESTV 246
+ L +G R LS FA LR++W SG LC++++ +++ + +LP SL +ES +
Sbjct: 155 DALIEMGVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKI 214
Query: 247 SSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQRGTLSQM 306
+ L+ + + T FL+ V T G ++ + LA +LL LA QRG+L +
Sbjct: 215 PPMGLDCLSQVTTFLKGV-------TIPNSGADTL---GRRLASELLLGLAAQRGSLRYL 264
Query: 307 LSAILLLL 314
L I + L
Sbjct: 265 LEWIEMAL 272
Score = 66.6 bits (161), Expect = 6e-10
Identities = 45/139 (32%), Positives = 72/139 (51%), Gaps = 20/139 (14%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 489
P + + L +G+ ++AC + + L+++G VYT + D L PQ +
Sbjct: 4230 PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 4287
Query: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549
LA I +A ++ H LALA+ G+VY+WG G+LG G T + EP +++
Sbjct: 4288 LAGVIIEDVAVGAE--HTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ---- 4341
Query: 550 GKHVVHIACGSTYSAAITA 568
GK+V I+ G +SAA TA
Sbjct: 4342 GKNVRQISAGRCHSAAWTA 4360
Score = 52.8 bits (125), Expect = 8e-06
Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 45/196 (22%)
Query: 1960 TAMMFTSTINLLQTLCLSAGVHAEIMQSEATKTLCGLL---------------------- 1997
TA+ ST LLQ L ++ G +A+ + + ++L LL
Sbjct: 1809 TALKVAST-RLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLHMASFGEG 1867
Query: 1998 ---------RMLVESGTTDKTSSPNRLVYREQHRSWCTLG----FVRSIALTPQVCGALS 2044
+ + SG T+K R R+QH + LG F+R + + + ++
Sbjct: 1868 EQEDGEEEEKKVDSSGETEKKDF--RAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMA 1925
Query: 2045 SPQWITLLMKVVEGHAPF---TATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKLF 2101
SP+W +L+ + +L+ ++LA+H+L+AVLP+ + M +VE+LF
Sbjct: 1926 SPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQIVERLF 1985
Query: 2102 DFLGSLLTTCSSDVPL 2117
SLL+ C + P+
Sbjct: 1986 ----SLLSDCMWETPI 1997
Score = 45.8 bits (107), Expect = 0.001
Identities = 56/225 (24%), Positives = 89/225 (39%), Gaps = 52/225 (23%)
Query: 2126 RRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWNGLINKYINSQLRSI----------- 2174
R + P + + ++ LAE + L+R LH +W INK + +L I
Sbjct: 2196 RDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKL 2255
Query: 2175 --THSFVGRPSEGAQLEDYFPDSENPEVGG--------------------LMAVLAVIGG 2212
+ S R + E +S+ E G + VLAVIGG
Sbjct: 2256 KKSRSVQSREENEMREEK---ESKEEEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGG 2312
Query: 2213 IDGRLRLGGQVMHDEFG-EGTVTRITPKG-----------KITVQFSDMRTCRVCPLNQL 2260
+D LR+GG+ +H + G T+ + +G +IT+ F + PL L
Sbjct: 2313 VDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSPSDTPLYNL 2372
Query: 2261 KPLPAVAFNVNNLPFTEPMLSVWAQLVNLAGSKLEKHKIKKSTKQ 2305
+P + F+V F SV L L G + + K+STK+
Sbjct: 2373 EPCEPLPFDVAR--FRGLTASVLLDLTYLTG--VHEDMGKQSTKR 2413
Score = 42.4 bits (98), Expect = 0.011
Identities = 41/137 (29%), Positives = 61/137 (44%), Gaps = 14/137 (10%)
Query: 2418 STHPSSPGFEDCSSSEATTPVAVQHIRPAR-------VKRRKQSPVPALPIVVQLMEMGF 2470
S+ P+SP E T+P + Q RPA R SP P I V L+EMGF
Sbjct: 2705 SSLPTSPSDEVGRRQSLTSPDS-QSARPANRTALSDPSSRLSTSPPPPA-IAVPLLEMGF 2762
Query: 2471 SRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVSDEYSDEEVVE 2530
S R I A+++ TGA G A + + L W+++H + E + + +D V+
Sbjct: 2763 SLRQIAKAMEA-TGARGEADA-QNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLG 2820
Query: 2531 D---VDDAAYSMSTGAV 2544
+D Y S G +
Sbjct: 2821 SGGKSNDPCYLQSPGDI 2837
Score = 38.9 bits (89), Expect = 0.13
Identities = 16/46 (34%), Positives = 29/46 (63%)
Query: 1302 LIDTERNLGLLLGLHASYLAMSTPLSPVEIECAKWLQSSIFSGGLQ 1347
L+D ER + LL+G + +P+SP E + A W+++ +FS G++
Sbjct: 1138 LVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVE 1183
Score = 37.0 bits (84), Expect = 0.48
Identities = 20/56 (35%), Positives = 29/56 (51%)
Query: 3753 LAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSF 3808
LA +LAAC S L++ HR WA Q+L + L + + L + G+ R SF
Sbjct: 3366 LANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSF 3421
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 637 bits (1643), Expect = 0.0
Identities = 323/347 (93%), Positives = 326/347 (93%), Gaps = 3/347 (0%)
Query: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQF LALTKSGVVWTWGK
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 3232 GDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGN 3291
GDYFRLGH SDVHVRKPQVVEGLRGKKIVHVAVGA HCLAV DSGQVYAWGDNDHGQQGN
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 794
Query: 3292 GTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASY 3351
GTTTVNRKP LVQGLEGQKI VACGSSHSVAWTT+DVATPSVHEPVLFQTARDPLGASY
Sbjct: 795 GTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASY 854
Query: 3352 LGVPSDADSSAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 3411
LGVPSD +SSAASNKISGASNSKP PSLAKILLSLDGNLAKQQALSHILTALQIMYARD
Sbjct: 855 LGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 914
Query: 3412 AVVGALMPAAMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKRE 3471
AVVGALMPAAMIAPVECP SAA SDA AMASPMNGEECMLAVDIEDRLSPNPWQEKRE
Sbjct: 915 AVVGALMPAAMIAPVECP---SAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKRE 971
Query: 3472 IVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKE 3518
IVSSED VTPSAVTPSA SASA PFI VTDD GAASI AETMTKT+E
Sbjct: 972 IVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEE 1018
Score = 215 bits (547), Expect = 1e-54
Identities = 92/158 (58%), Positives = 124/158 (78%)
Query: 4166 VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGD 4225
V+SWGDGD+GKLGRGGS+GC +P I+ L G GV ++ECG+QF +ALTKSG V+TWGKGD
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 736
Query: 4226 YHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGT 4285
Y RLGH SD HVR+P+ V+GL+GKK++ +A G+ HC+ + G+VY WGDND GQ G+GT
Sbjct: 737 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 796
Query: 4286 TNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPAS 4323
T ++P LV L+G+K+ VACGS+H++AW+T A+
Sbjct: 797 TTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVAT 834
Score = 171 bits (434), Expect = 1e-41
Identities = 75/155 (48%), Positives = 110/155 (70%)
Query: 624 GQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGK 683
G V+SWGDGD+GKLGRGGS+GC P+ IE+L V ++ CG+QF +ALTK G V++WGK
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 684 GDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFD 743
GD RLGH ++ HVR P+++EGL+GKK++ VA G+ HCLA+ + +V++WG ND Q +
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 794
Query: 744 TLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
+P + GL+ + I+ +ACG + S AW++
Sbjct: 795 GTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 829
Score = 126 bits (316), Expect = 6e-28
Identities = 62/156 (39%), Positives = 97/156 (62%), Gaps = 2/156 (1%)
Query: 570 GELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629
G +++WG G++G+LG G SE IP + L G V + CG+ LA+T++G VW+W
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWTW 732
Query: 630 GDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 689
G GDY +LG + P+++E L+ +V V G+Q +A+ GQVY+WG D+ +
Sbjct: 733 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 690 GHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALT 725
G+GT R P L++GL+G+K++ VA GS+H +A T
Sbjct: 793 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 124 bits (312), Expect = 2e-27
Identities = 65/166 (39%), Positives = 95/166 (57%), Gaps = 2/166 (1%)
Query: 3060 TALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 3119
T + G VFSWG+GD GKLG C+ P+ IE L + + I CG+ ALT SG
Sbjct: 669 TKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGV 728
Query: 3120 LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGD 3179
++TWG G+Y RLGH + KP++V+ L G +++ VA G++ LA+ D G V++WGD
Sbjct: 729 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQ--HCLAVMDSGQVYAWGD 786
Query: 3180 GDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGV 3225
D G+ G G + P ++ L GQ + + CG+ S+A T V
Sbjct: 787 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDV 832
Score = 120 bits (301), Expect = 3e-26
Identities = 63/160 (39%), Positives = 95/160 (59%), Gaps = 6/160 (3%)
Query: 514 GEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELY 573
G V+SWG GD G+LG G + P+ I + G+ V I CG+ + A+T G ++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN----GQGVCQIECGAQFLLALTKSGVVW 730
Query: 574 TWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGD 633
TWG+G+Y RLGH S P +V GL+G K++ VA G+ LAV ++GQV++WGD D
Sbjct: 731 TWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGA--QHCLAVMDSGQVYAWGDND 788
Query: 634 YGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALT 673
+G+ G G + + P L++ L+ ++ V CGS S+A T
Sbjct: 789 HGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 117 bits (293), Expect = 3e-25
Identities = 60/156 (38%), Positives = 87/156 (55%), Gaps = 2/156 (1%)
Query: 4110 GDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSW 4169
G +++WG G +G+LG SE P+ +E L G V I CG+ L LT VW+W
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWTW 732
Query: 4170 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4229
G GDY +LG + P ++ L G +V V G+Q +A+ SG VY WG D+ +
Sbjct: 733 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 4230 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 4265
G+G+ R+P VQGL+G+K++ +A GS H V T
Sbjct: 793 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 106 bits (265), Expect = 5e-22
Identities = 57/150 (38%), Positives = 91/150 (60%), Gaps = 3/150 (2%)
Query: 3011 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3070
G V++ G+ G+LG G S G IP+ I L+ V ++ G + ALT G V++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGC-NIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWT 731
Query: 3071 WGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGR 3130
WG+GD +LGH S ++ KP+++E L+ K+I +A G+ H A+ SG++Y WG ++G+
Sbjct: 732 WGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791
Query: 3131 LGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
G+G T KP +V+ L G +++ VACGS
Sbjct: 792 QGNGTTTVNRKPMLVQGLEGQKIMCVACGS 821
Score = 100 bits (250), Expect = 3e-20
Identities = 50/149 (33%), Positives = 86/149 (57%), Gaps = 2/149 (1%)
Query: 4004 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 4063
G +++ G G G+LG GG+E + P +E + + ++ G + LAL+ G V++W
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 732
Query: 4064 GEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL 4123
G+ + +LGH + +P+V+E LRG ++V VA G H V +G +Y WG +G+
Sbjct: 733 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 4124 GHSDSEDQLKPKLVEALQGHRVVDIACGS 4152
G+ + KP LV+ L+G +++ +ACGS
Sbjct: 793 GNGTTTVNRKPMLVQGLEGQKIMCVACGS 821
Score = 92.0 bits (227), Expect = 1e-17
Identities = 47/129 (36%), Positives = 77/129 (59%), Gaps = 6/129 (4%)
Query: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543
PQ ++ L + + +I + LAL +G V++WG GD RLGH V + +P+V+
Sbjct: 699 PQNIERLNGQGVCQIECGAQ--FLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEG 756
Query: 544 FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
GK+ +VH+A G+ + A+ G++Y WG ++G+ G+G++ PMLV GL+G
Sbjct: 757 LRGKK----IVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQ 812
Query: 604 KVIDVACGS 612
K++ VACGS
Sbjct: 813 KIMCVACGS 821
Score = 85.9 bits (211), Expect = 9e-16
Identities = 53/158 (33%), Positives = 82/158 (51%), Gaps = 6/158 (3%)
Query: 3952 GTIYGWGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYAT 4009
G ++ WG G+LG G EG + P E L Q+ G Q L A+T G ++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 732
Query: 4010 GYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4069
G G RLG V P ++E ++ I VAV G +HCLA+ G+VY+WG+ + G
Sbjct: 733 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWGDNDHG 790
Query: 4070 KLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVT 4107
+ G+G + +P +++ L G +++ VA G +HS T
Sbjct: 791 QQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 82.0 bits (201), Expect = 1e-14
Identities = 53/156 (33%), Positives = 81/156 (51%), Gaps = 3/156 (1%)
Query: 2961 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEAT 3020
VF WG D +LG +P E L+ V Q+ G++ L A+T G V+ G+
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 736
Query: 3021 NGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLG 3080
RLG S V P+ + L + VAV G +H A+ G+V++WG+ D G+ G
Sbjct: 737 YFRLGHR-SDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWGDNDHGQQG 793
Query: 3081 HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTS 3116
+ + KP L++ L+ ++I +ACGSSHS A T+
Sbjct: 794 NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 829
Score = 70.5 bits (171), Expect = 4e-11
Identities = 45/136 (33%), Positives = 71/136 (52%), Gaps = 16/136 (11%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYT--------QAYNSD--TLAPQLVQGLA 491
P E L GV QI C + L L+++G V+T + SD PQ+V+GL
Sbjct: 699 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLR 758
Query: 492 SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGK 551
+ IV +A H LA+ +G+VY+WG D G+ G+G T +P ++ G++
Sbjct: 759 GKKIVHVAV--GAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQK--- 813
Query: 552 HVVHIACGSTYSAAIT 567
++ +ACGS++S A T
Sbjct: 814 -IMCVACGSSHSVAWT 828
Score = 43.1 bits (100), Expect = 0.007
Identities = 20/56 (35%), Positives = 31/56 (55%)
Query: 4264 CTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319
C G V++WGD D G+LG G + P+ + L G+ V ++ CG+ LA + S
Sbjct: 671 CEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKS 726
Score = 42.0 bits (97), Expect = 0.015
Identities = 30/103 (29%), Positives = 45/103 (43%), Gaps = 2/103 (1%)
Query: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
SG ++ WG +LG V+ P E L + V + G Q AV G++YA G
Sbjct: 726 SGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWG 785
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLA 4053
G+ G G T P L++ ++ K + V G H +A
Sbjct: 786 DNDHGQQGNGTTTVNRKPMLVQGLEGQ--KIMCVACGSSHSVA 826
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 636 bits (1640), Expect = 0.0
Identities = 324/348 (93%), Positives = 326/348 (93%), Gaps = 3/348 (0%)
Query: 3171 EGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWG 3230
E LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQF LALTKSGVVWTWG
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
Query: 3231 KGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
KGDYFRLGH SDVHVRKPQVVEGLRGKKIVHVAVGA HCLAV DSGQVYAWGDNDHGQQG
Sbjct: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
Query: 3291 NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS 3350
NGTTTVNRKPTLVQGLEGQKI VACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS
Sbjct: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS 201
Query: 3351 YLGVPSDADSSAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYAR 3410
YLGVPSD +SSAASNKISGASNSKP PSLAKILLSLDGNLAKQQALSHILTALQIMYAR
Sbjct: 202 YLGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYAR 261
Query: 3411 DAVVGALMPAAMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKR 3470
DAVVGALMPAAMIAPVE F SAA SDA AMASPMNGEECMLAVDIEDRLSPNPWQEKR
Sbjct: 262 DAVVGALMPAAMIAPVE---FPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKR 318
Query: 3471 EIVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKE 3518
EIVSSED VTPSAVTPSA SASA PFI VTDD GAASI AETMTKT+E
Sbjct: 319 EIVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEE 366
Score = 215 bits (547), Expect = 1e-54
Identities = 91/156 (58%), Positives = 123/156 (78%)
Query: 4163 DDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWG 4222
+ V+SWGDGD+GKLGRGGS+GC +P I+ L G GV ++ECG+QF +ALTKSG V+TWG
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
Query: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
KGDY RLGH SD HVR+P+ V+GL+GKK++ +A G+ HC+ + G+VY WGDND GQ G
Sbjct: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
Query: 4283 DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWST 4318
+GTT ++P LV L+G+K+ VACGS+H++AW+T
Sbjct: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
Score = 170 bits (431), Expect = 3e-41
Identities = 74/153 (48%), Positives = 109/153 (71%)
Query: 626 VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGD 685
V+SWGDGD+GKLGRGGS+GC P+ IE+L V ++ CG+QF +ALTK G V++WGKGD
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 686 NQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL 745
RLGH ++ HVR P+++EGL+GKK++ VA G+ HCLA+ + +V++WG ND Q +
Sbjct: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144
Query: 746 RVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
+P + GL+ + I+ +ACG + S AW++
Sbjct: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
Score = 125 bits (315), Expect = 8e-28
Identities = 62/157 (39%), Positives = 97/157 (61%), Gaps = 2/157 (1%)
Query: 569 EGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWS 628
E +++WG G++G+LG G SE IP + L G V + CG+ LA+T++G VW+
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWT 79
Query: 629 WGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQR 688
WG GDY +LG + P+++E L+ +V V G+Q +A+ GQVY+WG D+ +
Sbjct: 80 WGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
Query: 689 LGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALT 725
G+GT R P L++GL+G+K++ VA GS+H +A T
Sbjct: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 121 bits (304), Expect = 1e-26
Identities = 62/154 (40%), Positives = 91/154 (59%), Gaps = 2/154 (1%)
Query: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3127
VFSWG+GD GKLG C+ P+ IE L + + I CG+ ALT SG ++TWG G+
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 3128 YGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGR 3187
Y RLGH + KP++V+ L G +++ VA G++ LA+ D G V++WGD D G+ G
Sbjct: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQ--HCLAVMDSGQVYAWGDNDHGQQGN 142
Query: 3188 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221
G + P ++ L GQ + + CG+ S+A T
Sbjct: 143 GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 119 bits (298), Expect = 7e-26
Identities = 62/158 (39%), Positives = 94/158 (59%), Gaps = 6/158 (3%)
Query: 516 VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 575
V+SWG GD G+LG G + P+ I + G+ V I CG+ + A+T G ++TW
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLN----GQGVCQIECGAQFLLALTKSGVVWTW 80
Query: 576 GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 635
G+G+Y RLGH S P +V GL+G K++ VA G+ LAV ++GQV++WGD D+G
Sbjct: 81 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGA--QHCLAVMDSGQVYAWGDNDHG 138
Query: 636 KLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALT 673
+ G G + + P L++ L+ ++ V CGS S+A T
Sbjct: 139 QQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 116 bits (291), Expect = 5e-25
Identities = 60/157 (38%), Positives = 87/157 (55%), Gaps = 2/157 (1%)
Query: 4057 EGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWG 4116
E V+SWG+ + GKLG G C+ P+ IE L G V + G +T +G ++TWG
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
Query: 4117 KGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGK 4176
KG Y RLGH KP++VE L+G ++V +A G+ L + D V++WGD D+G+
Sbjct: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGA--QHCLAVMDSGQVYAWGDNDHGQ 139
Query: 4177 LGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALT 4213
G G + + P + L G ++ V CGS SVA T
Sbjct: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 116 bits (291), Expect = 5e-25
Identities = 59/154 (38%), Positives = 86/154 (55%), Gaps = 2/154 (1%)
Query: 4112 LYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGD 4171
+++WG G +G+LG SE P+ +E L G V I CG+ L LT VW+WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWTWGK 82
Query: 4172 GDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGH 4231
GDY +LG + P ++ L G +V V G+Q +A+ SG VY WG D+ + G+
Sbjct: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Query: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 4265
G+ R+P VQGL+G+K++ +A GS H V T
Sbjct: 143 GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 106 bits (264), Expect = 6e-22
Identities = 57/151 (37%), Positives = 91/151 (60%), Gaps = 3/151 (1%)
Query: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3069
E V++ G+ G+LG G S G IP+ I L+ V ++ G + ALT G V+
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGC-NIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
Query: 3070 SWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG 3129
+WG+GD +LGH S ++ KP+++E L+ K+I +A G+ H A+ SG++Y WG ++G
Sbjct: 79 TWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHG 138
Query: 3130 RLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
+ G+G T KP +V+ L G +++ VACGS
Sbjct: 139 QQGNGTTTVNRKPTLVQGLEGQKIMCVACGS 169
Score = 99.4 bits (246), Expect = 8e-20
Identities = 49/147 (33%), Positives = 85/147 (57%), Gaps = 2/147 (1%)
Query: 4006 LYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
+++ G G G+LG GG+E + P +E + + ++ G + LAL+ G V++WG+
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTWGK 82
Query: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGH 4125
+ +LGH + +P+V+E LRG ++V VA G H V +G +Y WG +G+ G+
Sbjct: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Query: 4126 SDSEDQLKPKLVEALQGHRVVDIACGS 4152
+ KP LV+ L+G +++ +ACGS
Sbjct: 143 GTTTVNRKPTLVQGLEGQKIMCVACGS 169
Score = 89.7 bits (221), Expect = 6e-17
Identities = 46/129 (35%), Positives = 76/129 (58%), Gaps = 6/129 (4%)
Query: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543
PQ ++ L + + +I + LAL +G V++WG GD RLGH V + +P+V+
Sbjct: 47 PQNIERLNGQGVCQIECGAQ--FLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEG 104
Query: 544 FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
GK+ +VH+A G+ + A+ G++Y WG ++G+ G+G++ P LV GL+G
Sbjct: 105 LRGKK----IVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ 160
Query: 604 KVIDVACGS 612
K++ VACGS
Sbjct: 161 KIMCVACGS 169
Score = 85.1 bits (209), Expect = 2e-15
Identities = 53/162 (32%), Positives = 83/162 (51%), Gaps = 6/162 (3%)
Query: 3948 AGGSGTIYGWGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGK 4005
+G ++ WG G+LG G EG + P E L Q+ G Q L A+T G
Sbjct: 19 SGYESLVFSWGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGV 76
Query: 4006 LYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
++ G G RLG V P ++E ++ I VAV G +HCLA+ G+VY+WG+
Sbjct: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWGD 134
Query: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVT 4107
+ G+ G+G + +P +++ L G +++ VA G +HS T
Sbjct: 135 NDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 84.0 bits (206), Expect = 3e-15
Identities = 58/174 (33%), Positives = 88/174 (50%), Gaps = 9/174 (5%)
Query: 2943 LIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSK 3002
+I K +G ES VF WG D +LG +P E L+ V Q+ G++
Sbjct: 13 IILSKLSGYESL------VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ 66
Query: 3003 SLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATAL 3062
L A+T G V+ G+ RLG S V P+ + L + VAV G +H A+
Sbjct: 67 FLLALTKSGVVWTWGKGDYFRLGHR-SDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAV 123
Query: 3063 TVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTS 3116
G+V++WG+ D G+ G+ + KP L++ L+ ++I +ACGSSHS A T+
Sbjct: 124 MDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
Score = 70.5 bits (171), Expect = 4e-11
Identities = 45/136 (33%), Positives = 71/136 (52%), Gaps = 16/136 (11%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYT--------QAYNSD--TLAPQLVQGLA 491
P E L GV QI C + L L+++G V+T + SD PQ+V+GL
Sbjct: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLR 106
Query: 492 SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGK 551
+ IV +A H LA+ +G+VY+WG D G+ G+G T +P ++ G++
Sbjct: 107 GKKIVHVAV--GAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQK--- 161
Query: 552 HVVHIACGSTYSAAIT 567
++ +ACGS++S A T
Sbjct: 162 -IMCVACGSSHSVAWT 176
Score = 40.0 bits (92), Expect = 0.056
Identities = 18/50 (36%), Positives = 29/50 (58%)
Query: 4270 VYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319
V++WGD D G+LG G + P+ + L G+ V ++ CG+ LA + S
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKS 74
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 629 bits (1622), Expect = e-179
Identities = 321/347 (92%), Positives = 324/347 (93%), Gaps = 3/347 (0%)
Query: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQF LALTKSGVVWTWGK
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784
Query: 3232 GDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGN 3291
GDYFRLGH SDVHVRK QVVEGLRGKKIVHVAVGA HCLAV DSGQVYAWGDNDHGQQGN
Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844
Query: 3292 GTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASY 3351
GTTTVNRKP LVQGLEGQKI VACGSSHSVAWTT+DVATPSVHEPVLFQTARDPLGASY
Sbjct: 845 GTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASY 904
Query: 3352 LGVPSDADSSAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 3411
LGVPSD +SSAASNKISGASNSKP PSLAKILLSLDGNLAKQQALSHILTALQIMYARD
Sbjct: 905 LGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 964
Query: 3412 AVVGALMPAAMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKRE 3471
AVVGALMPAAMIAPVE F SAA SDA AMASPMNGEECMLAVDIEDRLSPNPWQEKRE
Sbjct: 965 AVVGALMPAAMIAPVE---FPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKRE 1021
Query: 3472 IVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKE 3518
IVSSED VTPSAVTPSA SASA PFI VTDD GAASI AETMTKT+E
Sbjct: 1022 IVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEE 1068
Score = 211 bits (537), Expect = 1e-53
Identities = 91/158 (57%), Positives = 123/158 (77%)
Query: 4166 VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGD 4225
V+SWGDGD+GKLGRGGS+GC +P I+ L G GV ++ECG+QF +ALTKSG V+TWGKGD
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 786
Query: 4226 YHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGT 4285
Y RLGH SD HVR+ + V+GL+GKK++ +A G+ HC+ + G+VY WGDND GQ G+GT
Sbjct: 787 YFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 846
Query: 4286 TNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPAS 4323
T ++P LV L+G+K+ VACGS+H++AW+T A+
Sbjct: 847 TTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVAT 884
Score = 167 bits (424), Expect = 2e-40
Identities = 74/155 (47%), Positives = 109/155 (70%)
Query: 624 GQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGK 683
G V+SWGDGD+GKLGRGGS+GC P+ IE+L V ++ CG+QF +ALTK G V++WGK
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784
Query: 684 GDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFD 743
GD RLGH ++ HVR +++EGL+GKK++ VA G+ HCLA+ + +V++WG ND Q +
Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844
Query: 744 TLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
+P + GL+ + I+ +ACG + S AW++
Sbjct: 845 GTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 879
Score = 122 bits (306), Expect = 9e-27
Identities = 61/156 (39%), Positives = 96/156 (61%), Gaps = 2/156 (1%)
Query: 570 GELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629
G +++WG G++G+LG G SE IP + L G V + CG+ LA+T++G VW+W
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWTW 782
Query: 630 GDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 689
G GDY +LG + +++E L+ +V V G+Q +A+ GQVY+WG D+ +
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 690 GHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALT 725
G+GT R P L++GL+G+K++ VA GS+H +A T
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Score = 120 bits (302), Expect = 3e-26
Identities = 64/166 (38%), Positives = 94/166 (56%), Gaps = 2/166 (1%)
Query: 3060 TALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 3119
T + G VFSWG+GD GKLG C+ P+ IE L + + I CG+ ALT SG
Sbjct: 719 TKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGV 778
Query: 3120 LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGD 3179
++TWG G+Y RLGH + K ++V+ L G +++ VA G++ LA+ D G V++WGD
Sbjct: 779 VWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQ--HCLAVMDSGQVYAWGD 836
Query: 3180 GDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGV 3225
D G+ G G + P ++ L GQ + + CG+ S+A T V
Sbjct: 837 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDV 882
Score = 116 bits (291), Expect = 5e-25
Identities = 62/160 (38%), Positives = 94/160 (58%), Gaps = 6/160 (3%)
Query: 514 GEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELY 573
G V+SWG GD G+LG G + P+ I + G+ V I CG+ + A+T G ++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN----GQGVCQIECGAQFLLALTKSGVVW 780
Query: 574 TWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGD 633
TWG+G+Y RLGH S +V GL+G K++ VA G+ LAV ++GQV++WGD D
Sbjct: 781 TWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGA--QHCLAVMDSGQVYAWGDND 838
Query: 634 YGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALT 673
+G+ G G + + P L++ L+ ++ V CGS S+A T
Sbjct: 839 HGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Score = 113 bits (283), Expect = 4e-24
Identities = 59/156 (37%), Positives = 86/156 (55%), Gaps = 2/156 (1%)
Query: 4110 GDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSW 4169
G +++WG G +G+LG SE P+ +E L G V I CG+ L LT VW+W
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWTW 782
Query: 4170 GDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4229
G GDY +LG + ++ L G +V V G+Q +A+ SG VY WG D+ +
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 4230 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 4265
G+G+ R+P VQGL+G+K++ +A GS H V T
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Score = 102 bits (255), Expect = 7e-21
Identities = 56/150 (37%), Positives = 90/150 (60%), Gaps = 3/150 (2%)
Query: 3011 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3070
G V++ G+ G+LG G S G IP+ I L+ V ++ G + ALT G V++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGC-NIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWT 781
Query: 3071 WGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGR 3130
WG+GD +LGH S ++ K +++E L+ K+I +A G+ H A+ SG++Y WG ++G+
Sbjct: 782 WGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 841
Query: 3131 LGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
G+G T KP +V+ L G +++ VACGS
Sbjct: 842 QGNGTTTVNRKPMLVQGLEGQKIMCVACGS 871
Score = 97.1 bits (240), Expect = 4e-19
Identities = 49/149 (32%), Positives = 85/149 (57%), Gaps = 2/149 (1%)
Query: 4004 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 4063
G +++ G G G+LG GG+E + P +E + + ++ G + LAL+ G V++W
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTW 782
Query: 4064 GEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL 4123
G+ + +LGH + + +V+E LRG ++V VA G H V +G +Y WG +G+
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 4124 GHSDSEDQLKPKLVEALQGHRVVDIACGS 4152
G+ + KP LV+ L+G +++ +ACGS
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGS 871
Score = 88.2 bits (217), Expect = 2e-16
Identities = 46/129 (35%), Positives = 76/129 (58%), Gaps = 6/129 (4%)
Query: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543
PQ ++ L + + +I + LAL +G V++WG GD RLGH V + + +V+
Sbjct: 749 PQNIERLNGQGVCQIECGAQ--FLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEG 806
Query: 544 FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
GK+ +VH+A G+ + A+ G++Y WG ++G+ G+G++ PMLV GL+G
Sbjct: 807 LRGKK----IVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQ 862
Query: 604 KVIDVACGS 612
K++ VACGS
Sbjct: 863 KIMCVACGS 871
Score = 82.0 bits (201), Expect = 1e-14
Identities = 52/158 (32%), Positives = 81/158 (51%), Gaps = 6/158 (3%)
Query: 3952 GTIYGWGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYAT 4009
G ++ WG G+LG G EG + P E L Q+ G Q L A+T G ++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 782
Query: 4010 GYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4069
G G RLG V ++E ++ I VAV G +HCLA+ G+VY+WG+ + G
Sbjct: 783 GKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWGDNDHG 840
Query: 4070 KLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVT 4107
+ G+G + +P +++ L G +++ VA G +HS T
Sbjct: 841 QQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Score = 78.6 bits (192), Expect = 1e-13
Identities = 51/157 (32%), Positives = 81/157 (51%), Gaps = 5/157 (3%)
Query: 2961 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEAT 3020
VF WG D +LG +P E L+ V Q+ G++ L A+T G V+ G+
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 786
Query: 3021 NGRLGLGISSGTVPIPRQITALSSYVVKKVA-VHSGGRHATALTVDGKVFSWGEGDDGKL 3079
RLG V + R++ + KK+ V G +H A+ G+V++WG+ D G+
Sbjct: 787 YFRLG---HRSDVHV-RKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 3080 GHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTS 3116
G+ + KP L++ L+ ++I +ACGSSHS A T+
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 879
Score = 67.0 bits (162), Expect = 4e-10
Identities = 44/136 (32%), Positives = 70/136 (51%), Gaps = 16/136 (11%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYT--------QAYNSDTLAP--QLVQGLA 491
P E L GV QI C + L L+++G V+T + SD Q+V+GL
Sbjct: 749 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLR 808
Query: 492 SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGK 551
+ IV +A H LA+ +G+VY+WG D G+ G+G T +P ++ G++
Sbjct: 809 GKKIVHVAV--GAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQK--- 863
Query: 552 HVVHIACGSTYSAAIT 567
++ +ACGS++S A T
Sbjct: 864 -IMCVACGSSHSVAWT 878
Score = 43.1 bits (100), Expect = 0.007
Identities = 20/56 (35%), Positives = 31/56 (55%)
Query: 4264 CTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319
C G V++WGD D G+LG G + P+ + L G+ V ++ CG+ LA + S
Sbjct: 721 CEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKS 776
Score = 38.1 bits (87), Expect = 0.21
Identities = 29/103 (28%), Positives = 44/103 (42%), Gaps = 2/103 (1%)
Query: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
SG ++ WG +LG V+ E L + V + G Q AV G++YA G
Sbjct: 776 SGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWG 835
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLA 4053
G+ G G T P L++ ++ K + V G H +A
Sbjct: 836 DNDHGQQGNGTTTVNRKPMLVQGLEGQ--KIMCVACGSSHSVA 876
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 188 bits (477), Expect = 1e-46
Identities = 122/337 (36%), Positives = 173/337 (51%), Gaps = 10/337 (2%)
Query: 2972 LGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSG 3031
LGG+ + P S+ V V G + V +G VY CG G+LG S
Sbjct: 14 LGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK 73
Query: 3032 TVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-P 3090
P Q+ AL + + VAV G H AL G+V++WG DG+LG C + P
Sbjct: 74 K---PEQVVALDAQNI--VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVP 128
Query: 3091 RLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQLKPKMVKVLL 3149
R I++L +I +ACG HS AL+ + E++ WG +YG+LG G D Q P+++K LL
Sbjct: 129 RNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
Query: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3209
G +QVA G A + LT G +F WG FG+LG +P ++ L Q +
Sbjct: 189 GIPFMQVAAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVY 246
Query: 3210 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3269
I CG + ALTK G V+T+G G Y +LGH S H P+ V L G + +A G H
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
Query: 3270 LA-VTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG 3305
A V SG++Y++G +GQ G G+T+ + P V+G
Sbjct: 307 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Score = 180 bits (456), Expect = 3e-44
Identities = 117/341 (34%), Positives = 173/341 (50%), Gaps = 11/341 (3%)
Query: 3957 WGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAG 4014
WG+ GQLG GI+ V P + R + G + V DG +Y G
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 4015 GRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG 4074
G+LG + + Q++ VAV+ G H LAL+ +G+VY+WG DG+LG
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNI----VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
Query: 4075 NRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-HSDSEDQL 4132
C R PR I+SL I++V VA G HS ++ A +++ WG+ +YG+LG +D + Q
Sbjct: 120 GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
Query: 4133 KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4192
P+L+++L G + +A G A + LT ++ WG +G+LG + VP +
Sbjct: 180 SPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237
Query: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVI 4252
SL +V + CG + ALTK G V+T+G G Y +LGH S H PR+V L G V
Sbjct: 238 SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297
Query: 4253 AIATGSLHCVCCT-EDGEVYTWGDNDEGQLGDGTTNAIQRP 4292
IA G H G +Y++G GQLG G+T+ + P
Sbjct: 298 EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
Score = 168 bits (425), Expect = 1e-40
Identities = 94/259 (36%), Positives = 139/259 (53%), Gaps = 8/259 (3%)
Query: 3071 WGEGDDGKLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128
WG G+LG +PR + KR+RD+ CG H+ + G +YT G +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
G+LGH ++ KP+ V L ++ V+CG +A TLAL D+G V++WG G+LG
Sbjct: 64 GQLGH--EKSRKKPEQVVALDAQNIVAVSCG--EAHTLALNDKGQVYAWGLDSDGQLGLV 119
Query: 3189 GSEGC-NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3246
GSE C +P+NI+ L+ + Q+ CG SLAL+K+ V+ WG+ Y +LG G+D +
Sbjct: 120 GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
Query: 3247 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306
PQ+++ L G + VA G H +T SG ++ WG N GQ G P L++ L
Sbjct: 180 SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Query: 3307 EGQKITRVACGSSHSVAWT 3325
QKI + CG H+ A T
Sbjct: 240 RSQKIVYICCGEDHTAALT 258
Score = 167 bits (424), Expect = 2e-40
Identities = 106/299 (35%), Positives = 167/299 (55%), Gaps = 13/299 (4%)
Query: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011
GT+Y G N GQLG + K P AL V + GE A+ G++YA G
Sbjct: 53 GTVYTCGCNDLGQLGHEKSRKK--PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 4012 GAGGRLG-IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070
+ G+LG +G E + P ++S+ + I +VA G H LALS EV+ WG+ + G+
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA--CGYYHSLALSKASEVFCWGQNKYGQ 168
Query: 4071 LGHGNRSPCDR---PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127
LG G + C + P++++SL GI + VAAGGAHS +T +G ++ WG+ ++G+LG +D
Sbjct: 169 LGLG--TDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLND 226
Query: 4128 SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKV 4187
D+ P L+++L+ ++V I C G+ T LT + V+++G G YG+LG +
Sbjct: 227 ENDRYVPNLLKSLRSQKIVYICC--GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEIN 284
Query: 4188 PMKIDSLTGLGVVKVECGSQFSVA-LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245
P K+ L G V ++ CG Q + A + SG +Y++G G +LG GS + + P V+G
Sbjct: 285 PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Score = 162 bits (409), Expect = 1e-38
Identities = 105/311 (33%), Positives = 160/311 (51%), Gaps = 9/311 (2%)
Query: 3017 GEATNGRLGLG-ISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075
G A+ G+LGLG I V PR+ + V+ V G RH + DG V++ G D
Sbjct: 5 GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGC--GLRHTVFVLDDGTVYTCGCND 62
Query: 3076 DGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH-G 3134
G+LGH + KP + AL + I ++CG +H+ AL G++Y WGL G+LG G
Sbjct: 63 LGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 3135 DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGS-EGC 3193
P+ +K L +++QVACG +LAL+ VF WG +G+LG G +
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYY--HSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178
Query: 3194 NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG 3253
PQ ++ L G Q+ G S LT SG ++ WG+ + +LG + P +++
Sbjct: 179 TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS 238
Query: 3254 LRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITR 3313
LR +KIV++ G H A+T G V+ +G +GQ G+ +T+ P V L G +T
Sbjct: 239 LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTE 298
Query: 3314 VACGSSHSVAW 3324
+ACG H+ A+
Sbjct: 299 IACGRQHTSAF 309
Score = 154 bits (388), Expect = 3e-36
Identities = 101/317 (31%), Positives = 163/317 (51%), Gaps = 16/317 (5%)
Query: 4010 GYGAGGRLGIGGTESVSTPTLLESIQHVFI--KKVA-VNSGGKHCLALSSEGEVYSWGEA 4066
G + G+LG+GG + +LE + F K+V V G +H + + +G VY+ G
Sbjct: 5 GNASFGQLGLGG---IDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCN 61
Query: 4067 EDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126
+ G+LGH +P + +L +V V+ G AH+ + G +Y WG G+LG
Sbjct: 62 DLGQLGHEKSRK--KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
Query: 4127 DSEDQLK-PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4185
SE+ ++ P+ +++L ++V +ACG +L L+ V+ WG YG+LG G C
Sbjct: 120 GSEECIRVPRNIKSLSDIQIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTD--C 175
Query: 4186 KV---PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQ 4242
K P + SL G+ ++V G S LT SGA++ WG+ + +LG ++ P
Sbjct: 176 KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235
Query: 4243 VQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKK 4302
++ L+ +K++ I G H T++G V+T+G GQLG +T+ PR V L G
Sbjct: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
Query: 4303 VNRVACGSAHTLAWSTS 4319
V +ACG HT A+ S
Sbjct: 296 VTEIACGRQHTSAFVPS 312
Score = 143 bits (361), Expect = 4e-33
Identities = 90/271 (33%), Positives = 146/271 (53%), Gaps = 10/271 (3%)
Query: 2960 KVFVWGLNDKDQLGGLKGSK--IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017
+V+ WGL+ QLG L GS+ I+VP ++LS + +VQVA G A++ +V+ G
Sbjct: 104 QVYAWGLDSDGQLG-LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG 162
Query: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077
+ G+LGLG P+ + +L +VA +GG H+ LT+ G +F WG G
Sbjct: 163 QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA--AGGAHSFVLTLSGAIFGWGRNKFG 220
Query: 3078 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3137
+LG + P L+++L++++I I CG H+AALT G ++T+G G YG+LGH +
Sbjct: 221 QLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTS 280
Query: 3138 TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQ 3197
++ P+ V L+G V ++ACG R + + G ++S+G G G+LG G + P
Sbjct: 281 HEINPRKVFELMGSIVTEIACG-RQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPF 339
Query: 3198 NIE----RLNGQGVCQIECGAQFSLALTKSG 3224
++ NGQ + I+ F + SG
Sbjct: 340 TVKGNWYPYNGQCLPDIDSEEYFCVKRIFSG 370
Score = 142 bits (359), Expect = 6e-33
Identities = 91/307 (29%), Positives = 152/307 (49%), Gaps = 19/307 (6%)
Query: 439 VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 490
V+ P + + N V + C + + + +G VYT N P+ V L
Sbjct: 22 VLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVAL 81
Query: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH-GDTVPLEEPKVISAFSGKQA 549
++NIV ++ H LAL G+VY+WG G+LG G + P+ I + S Q
Sbjct: 82 DAQNIVAVSCGEA--HTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQ- 138
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDV 608
+V +ACG +S A++ E++ WG+ YG+LG G+ + + P L+ L G+ + V
Sbjct: 139 ---IVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195
Query: 609 ACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQF 668
A G A + +T +G ++ WG +G+LG + P L++ L+ +V + CG
Sbjct: 196 AAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDH 253
Query: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS 728
+ ALTK+G V+++G G +LGH + H P+ + L G V ++A G H A S
Sbjct: 254 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSS 313
Query: 729 -EVHSWG 734
++S+G
Sbjct: 314 GRIYSFG 320
Score = 130 bits (327), Expect = 3e-29
Identities = 84/287 (29%), Positives = 146/287 (50%), Gaps = 16/287 (5%)
Query: 506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 565
H + + G VY+ GC D G+LGH + ++P+ + A + ++V ++CG ++ A
Sbjct: 45 HTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQ----NIVAVSCGEAHTLA 98
Query: 566 ITAEGELYTWGRGNYGRLGH-GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENG 624
+ +G++Y WG + G+LG GS E +P + L ++++ VACG +LA+++
Sbjct: 99 LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY--YHSLALSKAS 156
Query: 625 QVWSWGDGDYGKLGRGGSDGCK---TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSW 681
+V+ WG YG+LG G CK +P+L++ L + ++V G S LT G ++ W
Sbjct: 157 EVFCWGQNKYGQLGLGTD--CKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 682 GKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQH 741
G+ +LG E P LL+ L+ +K++ + G H ALT++ V ++G+ Q
Sbjct: 215 GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 742 FDTLRVTKPEPAALPGLDTKHIVGIACG--PAQSFAWSSCSEWSIGL 786
+ P + L + IACG +F SS +S GL
Sbjct: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGL 321
Score = 130 bits (326), Expect = 4e-29
Identities = 74/249 (29%), Positives = 134/249 (53%), Gaps = 5/249 (2%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAK-VKVPTPCEALATLRPVQLIGGEQTLFAVTAD 4003
TL+ G +Y WG + GQLG + + ++VP ++L+ ++ VQ+ G A++
Sbjct: 96 TLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155
Query: 4004 GKLYATGYGAGGRLGIG-GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4062
+++ G G+LG+G + ++P LL+S+ + +VA +GG H L+ G ++
Sbjct: 156 SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA--AGGAHSFVLTLSGAIFG 213
Query: 4063 WGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGR 4122
WG + G+LG + + P +++SLR ++V + G H+A +T G ++T+G G YG+
Sbjct: 214 WGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273
Query: 4123 LGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGS 4182
LGH+ + ++ P+ V L G V +IACG + ++S+G G G+LG G +
Sbjct: 274 LGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF-VPSSGRIYSFGLGGNGQLGTGST 332
Query: 4183 DGCKVPMKI 4191
K P +
Sbjct: 333 SNRKSPFTV 341
Score = 127 bits (320), Expect = 2e-28
Identities = 88/329 (26%), Positives = 151/329 (45%), Gaps = 28/329 (8%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490
P Q L + ++C E L L+ G+VY +SD P+ ++ L
Sbjct: 75 PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHG-DTVPLEEPKVISAFSGKQA 549
+ IV++A +H LAL+ EV+ WG G+LG G D P+++ + G
Sbjct: 135 SDIQIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP- 191
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
+ +A G +S +T G ++ WGR +G+LG D +P L+ L+ K++ +
Sbjct: 192 ---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYIC 248
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
CG + T A+T+ G V+++G G YG+LG + P+ + +L V ++ CG Q +
Sbjct: 249 CG--EDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
Query: 670 IALT-KDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG----LQGKKVIDVAAGSTHCLAL 724
A G++YS+G G N +LG G+ + + P ++G G+ + D+ + C+
Sbjct: 307 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR 366
Query: 725 T---EDSEVHSWGSNDQCQHFDTLRVTKP 750
D + S C D R P
Sbjct: 367 IFSGGDQSFSHYSSPQNCGPPDDFRCPNP 395
Score = 103 bits (256), Expect = 5e-21
Identities = 68/190 (35%), Positives = 99/190 (52%), Gaps = 5/190 (2%)
Query: 2959 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017
++VF WG N QLG G K P ++L + +QVA G F +T+ G ++ G
Sbjct: 156 SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077
G+LGL + +P + +L S K V + G H ALT +G VF++G G G
Sbjct: 216 RNKFGQLGLNDENDRY-VPNLLKSLRSQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
Query: 3078 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSH-SAALTSSGELYTWGLGEYGRLGHGDN 3136
+LGH S + PR + L + +IACG H SA + SSG +Y++GLG G+LG G
Sbjct: 273 QLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
Query: 3137 TTQLKPKMVK 3146
+ + P VK
Sbjct: 333 SNRKSPFTVK 342
Score = 100 bits (250), Expect = 3e-20
Identities = 71/249 (28%), Positives = 108/249 (43%), Gaps = 56/249 (22%)
Query: 575 WGRGNYGRLGHGSSEDEAI----------------------------------------- 593
WG ++G+LG G ++E +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 594 -----------PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS 642
P V L ++ V+C G+A TLA+ + GQV++WG G+LG GS
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNIVAVSC--GEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
Query: 643 DGC-KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE-EHVRYP 700
+ C + P+ I+ L D+ +V+V CG S+AL+K +V+ WG+ +LG GT+ + P
Sbjct: 122 EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSP 181
Query: 701 KLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDT 760
+LL+ L G + VAAG H LT + WG N Q + P L L +
Sbjct: 182 QLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS 241
Query: 761 KHIVGIACG 769
+ IV I CG
Sbjct: 242 QKIVYICCG 250
Score = 94.0 bits (232), Expect = 3e-18
Identities = 92/328 (28%), Positives = 144/328 (43%), Gaps = 27/328 (8%)
Query: 4467 KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA 4526
KV FVGE D GG E I EL + + + R L+ + +
Sbjct: 731 KVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSR----------LIWFSDKT 780
Query: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
S +F +GV+ G+AI + + L+ ++K+L ++ DL E+ D + +
Sbjct: 781 FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL 840
Query: 4587 RDN-EATSEEFEAMSLPFTVPSASGQDIQ---LSSKHTHITLDNRAEYVRLAINYRLHEF 4642
D E EE ++ TV + +++ L+ T + NR E+V ++Y F
Sbjct: 841 LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYI---F 897
Query: 4643 DEQVA----AVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPS 4697
++ VA A G +V +L LF EL+ MV G+ + L+ YKG
Sbjct: 898 NKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAE 957
Query: 4698 ASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLP 4757
I+ FWEV ++ FL F+ G R+P I + VIQ + +LP
Sbjct: 958 HPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIP--ILGMKSLKLVIQ---STGGGEEYLP 1012
Query: 4758 ESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
S+TCF LL LP+Y+ K+ L KL AI
Sbjct: 1013 VSHTCFNLLDLPKYTEKETLRSKLIQAI 1040
Score = 72.4 bits (176), Expect = 1e-11
Identities = 49/160 (30%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 629 WGDGDYGKLGRGGSDG--CKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN 686
WG+ +G+LG GG D P+ + + V V CG + ++ + DG VY+ G D
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 687 QRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-----H 741
+LGH E+ + P+ + L + ++ V+ G H LAL + +V++WG + Q
Sbjct: 64 GQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
Query: 742 FDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781
+ +RV P + L IV +ACG S A S SE
Sbjct: 122 EECIRV----PRNIKSLSDIQIVQVACGYYHSLALSKASE 157
Score = 63.9 bits (154), Expect = 4e-09
Identities = 42/137 (30%), Positives = 68/137 (49%), Gaps = 3/137 (2%)
Query: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
SG I+GWG N GQLG + VP ++L + + V + GE A+T +G ++ G
Sbjct: 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 267
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLA-LSSEGEVYSWGEAEDG 4069
G G+LG T P + + + ++A G +H A + S G +YS+G +G
Sbjct: 268 AGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA--CGRQHTSAFVPSSGRIYSFGLGGNG 325
Query: 4070 KLGHGNRSPCDRPRVIE 4086
+LG G+ S P ++
Sbjct: 326 QLGTGSTSNRKSPFTVK 342
Score = 58.9 bits (141), Expect = 1e-07
Identities = 41/136 (30%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015
T+ +F WG N QLG + VP+ ++L + +V + G A+T EG V+
Sbjct: 206 TLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFT 265
Query: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATA-LTVDGKVFSWGEG 3074
G G+LG +S + PR++ L +V ++A G +H +A + G+++S+G G
Sbjct: 266 FGAGGYGQLGHNSTSHEIN-PRKVFELMGSIVTEIA--CGRQHTSAFVPSSGRIYSFGLG 322
Query: 3075 DDGKLGHFSRMNCDKP 3090
+G+LG S N P
Sbjct: 323 GNGQLGTGSTSNRKSP 338
Score = 50.1 bits (118), Expect = 5e-05
Identities = 37/117 (31%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 681 WGKGDNQRLGHG--TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQ 738
WG +LG G EE V P+ + K+V DV G H + + +D V++ G ND
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 739 CQHFDTLRVTKPEPAALPGLDTKHIVGIACGPA---------QSFAWSSCSEWSIGL 786
Q KPE LD ++IV ++CG A Q +AW S+ +GL
Sbjct: 64 GQLGHEKSRKKPEQVV--ALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 188 bits (477), Expect = 1e-46
Identities = 122/337 (36%), Positives = 173/337 (51%), Gaps = 10/337 (2%)
Query: 2972 LGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSG 3031
LGG+ + P S+ V V G + V +G VY CG G+LG S
Sbjct: 14 LGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK 73
Query: 3032 TVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-P 3090
P Q+ AL + + VAV G H AL G+V++WG DG+LG C + P
Sbjct: 74 K---PEQVVALDAQNI--VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVP 128
Query: 3091 RLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQLKPKMVKVLL 3149
R I++L +I +ACG HS AL+ + E++ WG +YG+LG G D Q P+++K LL
Sbjct: 129 RNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
Query: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3209
G +QVA G A + LT G +F WG FG+LG +P ++ L Q +
Sbjct: 189 GIPFMQVAAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVY 246
Query: 3210 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3269
I CG + ALTK G V+T+G G Y +LGH S H P+ V L G + +A G H
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
Query: 3270 LA-VTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG 3305
A V SG++Y++G +GQ G G+T+ + P V+G
Sbjct: 307 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Score = 180 bits (456), Expect = 3e-44
Identities = 117/341 (34%), Positives = 173/341 (50%), Gaps = 11/341 (3%)
Query: 3957 WGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAG 4014
WG+ GQLG GI+ V P + R + G + V DG +Y G
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 4015 GRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG 4074
G+LG + + Q++ VAV+ G H LAL+ +G+VY+WG DG+LG
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNI----VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
Query: 4075 NRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-HSDSEDQL 4132
C R PR I+SL I++V VA G HS ++ A +++ WG+ +YG+LG +D + Q
Sbjct: 120 GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
Query: 4133 KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4192
P+L+++L G + +A G A + LT ++ WG +G+LG + VP +
Sbjct: 180 SPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237
Query: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVI 4252
SL +V + CG + ALTK G V+T+G G Y +LGH S H PR+V L G V
Sbjct: 238 SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297
Query: 4253 AIATGSLHCVCCT-EDGEVYTWGDNDEGQLGDGTTNAIQRP 4292
IA G H G +Y++G GQLG G+T+ + P
Sbjct: 298 EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
Score = 168 bits (425), Expect = 1e-40
Identities = 94/259 (36%), Positives = 139/259 (53%), Gaps = 8/259 (3%)
Query: 3071 WGEGDDGKLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128
WG G+LG +PR + KR+RD+ CG H+ + G +YT G +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
G+LGH ++ KP+ V L ++ V+CG +A TLAL D+G V++WG G+LG
Sbjct: 64 GQLGH--EKSRKKPEQVVALDAQNIVAVSCG--EAHTLALNDKGQVYAWGLDSDGQLGLV 119
Query: 3189 GSEGC-NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3246
GSE C +P+NI+ L+ + Q+ CG SLAL+K+ V+ WG+ Y +LG G+D +
Sbjct: 120 GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
Query: 3247 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306
PQ+++ L G + VA G H +T SG ++ WG N GQ G P L++ L
Sbjct: 180 SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Query: 3307 EGQKITRVACGSSHSVAWT 3325
QKI + CG H+ A T
Sbjct: 240 RSQKIVYICCGEDHTAALT 258
Score = 167 bits (424), Expect = 2e-40
Identities = 106/299 (35%), Positives = 167/299 (55%), Gaps = 13/299 (4%)
Query: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011
GT+Y G N GQLG + K P AL V + GE A+ G++YA G
Sbjct: 53 GTVYTCGCNDLGQLGHEKSRKK--PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 4012 GAGGRLG-IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070
+ G+LG +G E + P ++S+ + I +VA G H LALS EV+ WG+ + G+
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA--CGYYHSLALSKASEVFCWGQNKYGQ 168
Query: 4071 LGHGNRSPCDR---PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127
LG G + C + P++++SL GI + VAAGGAHS +T +G ++ WG+ ++G+LG +D
Sbjct: 169 LGLG--TDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLND 226
Query: 4128 SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKV 4187
D+ P L+++L+ ++V I C G+ T LT + V+++G G YG+LG +
Sbjct: 227 ENDRYVPNLLKSLRSQKIVYICC--GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEIN 284
Query: 4188 PMKIDSLTGLGVVKVECGSQFSVA-LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245
P K+ L G V ++ CG Q + A + SG +Y++G G +LG GS + + P V+G
Sbjct: 285 PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Score = 162 bits (409), Expect = 1e-38
Identities = 105/311 (33%), Positives = 160/311 (51%), Gaps = 9/311 (2%)
Query: 3017 GEATNGRLGLG-ISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075
G A+ G+LGLG I V PR+ + V+ V G RH + DG V++ G D
Sbjct: 5 GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGC--GLRHTVFVLDDGTVYTCGCND 62
Query: 3076 DGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH-G 3134
G+LGH + KP + AL + I ++CG +H+ AL G++Y WGL G+LG G
Sbjct: 63 LGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 3135 DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGS-EGC 3193
P+ +K L +++QVACG +LAL+ VF WG +G+LG G +
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYY--HSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178
Query: 3194 NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG 3253
PQ ++ L G Q+ G S LT SG ++ WG+ + +LG + P +++
Sbjct: 179 TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS 238
Query: 3254 LRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITR 3313
LR +KIV++ G H A+T G V+ +G +GQ G+ +T+ P V L G +T
Sbjct: 239 LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTE 298
Query: 3314 VACGSSHSVAW 3324
+ACG H+ A+
Sbjct: 299 IACGRQHTSAF 309
Score = 154 bits (388), Expect = 3e-36
Identities = 101/317 (31%), Positives = 163/317 (51%), Gaps = 16/317 (5%)
Query: 4010 GYGAGGRLGIGGTESVSTPTLLESIQHVFI--KKVA-VNSGGKHCLALSSEGEVYSWGEA 4066
G + G+LG+GG + +LE + F K+V V G +H + + +G VY+ G
Sbjct: 5 GNASFGQLGLGG---IDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCN 61
Query: 4067 EDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126
+ G+LGH +P + +L +V V+ G AH+ + G +Y WG G+LG
Sbjct: 62 DLGQLGHEKSRK--KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
Query: 4127 DSEDQLK-PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4185
SE+ ++ P+ +++L ++V +ACG +L L+ V+ WG YG+LG G C
Sbjct: 120 GSEECIRVPRNIKSLSDIQIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTD--C 175
Query: 4186 KV---PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQ 4242
K P + SL G+ ++V G S LT SGA++ WG+ + +LG ++ P
Sbjct: 176 KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235
Query: 4243 VQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKK 4302
++ L+ +K++ I G H T++G V+T+G GQLG +T+ PR V L G
Sbjct: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
Query: 4303 VNRVACGSAHTLAWSTS 4319
V +ACG HT A+ S
Sbjct: 296 VTEIACGRQHTSAFVPS 312
Score = 143 bits (361), Expect = 4e-33
Identities = 90/271 (33%), Positives = 146/271 (53%), Gaps = 10/271 (3%)
Query: 2960 KVFVWGLNDKDQLGGLKGSK--IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017
+V+ WGL+ QLG L GS+ I+VP ++LS + +VQVA G A++ +V+ G
Sbjct: 104 QVYAWGLDSDGQLG-LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG 162
Query: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077
+ G+LGLG P+ + +L +VA +GG H+ LT+ G +F WG G
Sbjct: 163 QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA--AGGAHSFVLTLSGAIFGWGRNKFG 220
Query: 3078 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3137
+LG + P L+++L++++I I CG H+AALT G ++T+G G YG+LGH +
Sbjct: 221 QLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTS 280
Query: 3138 TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQ 3197
++ P+ V L+G V ++ACG R + + G ++S+G G G+LG G + P
Sbjct: 281 HEINPRKVFELMGSIVTEIACG-RQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPF 339
Query: 3198 NIE----RLNGQGVCQIECGAQFSLALTKSG 3224
++ NGQ + I+ F + SG
Sbjct: 340 TVKGNWYPYNGQCLPDIDSEEYFCVKRIFSG 370
Score = 142 bits (359), Expect = 6e-33
Identities = 91/307 (29%), Positives = 152/307 (49%), Gaps = 19/307 (6%)
Query: 439 VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 490
V+ P + + N V + C + + + +G VYT N P+ V L
Sbjct: 22 VLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVAL 81
Query: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH-GDTVPLEEPKVISAFSGKQA 549
++NIV ++ H LAL G+VY+WG G+LG G + P+ I + S Q
Sbjct: 82 DAQNIVAVSCGEA--HTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQ- 138
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDV 608
+V +ACG +S A++ E++ WG+ YG+LG G+ + + P L+ L G+ + V
Sbjct: 139 ---IVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195
Query: 609 ACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQF 668
A G A + +T +G ++ WG +G+LG + P L++ L+ +V + CG
Sbjct: 196 AAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDH 253
Query: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS 728
+ ALTK+G V+++G G +LGH + H P+ + L G V ++A G H A S
Sbjct: 254 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSS 313
Query: 729 -EVHSWG 734
++S+G
Sbjct: 314 GRIYSFG 320
Score = 130 bits (327), Expect = 3e-29
Identities = 84/287 (29%), Positives = 146/287 (50%), Gaps = 16/287 (5%)
Query: 506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 565
H + + G VY+ GC D G+LGH + ++P+ + A + ++V ++CG ++ A
Sbjct: 45 HTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQ----NIVAVSCGEAHTLA 98
Query: 566 ITAEGELYTWGRGNYGRLGH-GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENG 624
+ +G++Y WG + G+LG GS E +P + L ++++ VACG +LA+++
Sbjct: 99 LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY--YHSLALSKAS 156
Query: 625 QVWSWGDGDYGKLGRGGSDGCK---TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSW 681
+V+ WG YG+LG G CK +P+L++ L + ++V G S LT G ++ W
Sbjct: 157 EVFCWGQNKYGQLGLGTD--CKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 682 GKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQH 741
G+ +LG E P LL+ L+ +K++ + G H ALT++ V ++G+ Q
Sbjct: 215 GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 742 FDTLRVTKPEPAALPGLDTKHIVGIACG--PAQSFAWSSCSEWSIGL 786
+ P + L + IACG +F SS +S GL
Sbjct: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGL 321
Score = 130 bits (326), Expect = 4e-29
Identities = 74/249 (29%), Positives = 134/249 (53%), Gaps = 5/249 (2%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAK-VKVPTPCEALATLRPVQLIGGEQTLFAVTAD 4003
TL+ G +Y WG + GQLG + + ++VP ++L+ ++ VQ+ G A++
Sbjct: 96 TLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKA 155
Query: 4004 GKLYATGYGAGGRLGIG-GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4062
+++ G G+LG+G + ++P LL+S+ + +VA +GG H L+ G ++
Sbjct: 156 SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA--AGGAHSFVLTLSGAIFG 213
Query: 4063 WGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGR 4122
WG + G+LG + + P +++SLR ++V + G H+A +T G ++T+G G YG+
Sbjct: 214 WGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273
Query: 4123 LGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGS 4182
LGH+ + ++ P+ V L G V +IACG + ++S+G G G+LG G +
Sbjct: 274 LGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF-VPSSGRIYSFGLGGNGQLGTGST 332
Query: 4183 DGCKVPMKI 4191
K P +
Sbjct: 333 SNRKSPFTV 341
Score = 127 bits (320), Expect = 2e-28
Identities = 88/329 (26%), Positives = 151/329 (45%), Gaps = 28/329 (8%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490
P Q L + ++C E L L+ G+VY +SD P+ ++ L
Sbjct: 75 PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHG-DTVPLEEPKVISAFSGKQA 549
+ IV++A +H LAL+ EV+ WG G+LG G D P+++ + G
Sbjct: 135 SDIQIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP- 191
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
+ +A G +S +T G ++ WGR +G+LG D +P L+ L+ K++ +
Sbjct: 192 ---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYIC 248
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
CG + T A+T+ G V+++G G YG+LG + P+ + +L V ++ CG Q +
Sbjct: 249 CG--EDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
Query: 670 IALT-KDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG----LQGKKVIDVAAGSTHCLAL 724
A G++YS+G G N +LG G+ + + P ++G G+ + D+ + C+
Sbjct: 307 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR 366
Query: 725 T---EDSEVHSWGSNDQCQHFDTLRVTKP 750
D + S C D R P
Sbjct: 367 IFSGGDQSFSHYSSPQNCGPPDDFRCPNP 395
Score = 103 bits (256), Expect = 5e-21
Identities = 68/190 (35%), Positives = 99/190 (52%), Gaps = 5/190 (2%)
Query: 2959 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017
++VF WG N QLG G K P ++L + +QVA G F +T+ G ++ G
Sbjct: 156 SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077
G+LGL + +P + +L S K V + G H ALT +G VF++G G G
Sbjct: 216 RNKFGQLGLNDENDRY-VPNLLKSLRSQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
Query: 3078 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSH-SAALTSSGELYTWGLGEYGRLGHGDN 3136
+LGH S + PR + L + +IACG H SA + SSG +Y++GLG G+LG G
Sbjct: 273 QLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
Query: 3137 TTQLKPKMVK 3146
+ + P VK
Sbjct: 333 SNRKSPFTVK 342
Score = 100 bits (250), Expect = 3e-20
Identities = 71/249 (28%), Positives = 108/249 (43%), Gaps = 56/249 (22%)
Query: 575 WGRGNYGRLGHGSSEDEAI----------------------------------------- 593
WG ++G+LG G ++E +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 594 -----------PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS 642
P V L ++ V+C G+A TLA+ + GQV++WG G+LG GS
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNIVAVSC--GEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
Query: 643 DGC-KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE-EHVRYP 700
+ C + P+ I+ L D+ +V+V CG S+AL+K +V+ WG+ +LG GT+ + P
Sbjct: 122 EECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSP 181
Query: 701 KLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDT 760
+LL+ L G + VAAG H LT + WG N Q + P L L +
Sbjct: 182 QLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS 241
Query: 761 KHIVGIACG 769
+ IV I CG
Sbjct: 242 QKIVYICCG 250
Score = 94.0 bits (232), Expect = 3e-18
Identities = 92/328 (28%), Positives = 144/328 (43%), Gaps = 27/328 (8%)
Query: 4467 KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA 4526
KV FVGE D GG E I EL + + + R L+ + +
Sbjct: 739 KVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSR----------LIWFSDKT 788
Query: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
S +F +GV+ G+AI + + L+ ++K+L ++ DL E+ D + +
Sbjct: 789 FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL 848
Query: 4587 RDN-EATSEEFEAMSLPFTVPSASGQDIQ---LSSKHTHITLDNRAEYVRLAINYRLHEF 4642
D E EE ++ TV + +++ L+ T + NR E+V ++Y F
Sbjct: 849 LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYI---F 905
Query: 4643 DEQVA----AVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPS 4697
++ VA A G +V +L LF EL+ MV G+ + L+ YKG
Sbjct: 906 NKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAE 965
Query: 4698 ASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLP 4757
I+ FWEV ++ FL F+ G R+P I + VIQ + +LP
Sbjct: 966 HPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIP--ILGMKSLKLVIQ---STGGGEEYLP 1020
Query: 4758 ESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
S+TCF LL LP+Y+ K+ L KL AI
Sbjct: 1021 VSHTCFNLLDLPKYTEKETLRSKLIQAI 1048
Score = 72.4 bits (176), Expect = 1e-11
Identities = 49/160 (30%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 629 WGDGDYGKLGRGGSDG--CKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN 686
WG+ +G+LG GG D P+ + + V V CG + ++ + DG VY+ G D
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 687 QRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-----H 741
+LGH E+ + P+ + L + ++ V+ G H LAL + +V++WG + Q
Sbjct: 64 GQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
Query: 742 FDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781
+ +RV P + L IV +ACG S A S SE
Sbjct: 122 EECIRV----PRNIKSLSDIQIVQVACGYYHSLALSKASE 157
Score = 63.9 bits (154), Expect = 4e-09
Identities = 42/137 (30%), Positives = 68/137 (49%), Gaps = 3/137 (2%)
Query: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
SG I+GWG N GQLG + VP ++L + + V + GE A+T +G ++ G
Sbjct: 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 267
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLA-LSSEGEVYSWGEAEDG 4069
G G+LG T P + + + ++A G +H A + S G +YS+G +G
Sbjct: 268 AGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA--CGRQHTSAFVPSSGRIYSFGLGGNG 325
Query: 4070 KLGHGNRSPCDRPRVIE 4086
+LG G+ S P ++
Sbjct: 326 QLGTGSTSNRKSPFTVK 342
Score = 58.9 bits (141), Expect = 1e-07
Identities = 41/136 (30%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015
T+ +F WG N QLG + VP+ ++L + +V + G A+T EG V+
Sbjct: 206 TLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFT 265
Query: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATA-LTVDGKVFSWGEG 3074
G G+LG +S + PR++ L +V ++A G +H +A + G+++S+G G
Sbjct: 266 FGAGGYGQLGHNSTSHEIN-PRKVFELMGSIVTEIA--CGRQHTSAFVPSSGRIYSFGLG 322
Query: 3075 DDGKLGHFSRMNCDKP 3090
+G+LG S N P
Sbjct: 323 GNGQLGTGSTSNRKSP 338
Score = 50.1 bits (118), Expect = 5e-05
Identities = 37/117 (31%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 681 WGKGDNQRLGHG--TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQ 738
WG +LG G EE V P+ + K+V DV G H + + +D V++ G ND
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 739 CQHFDTLRVTKPEPAALPGLDTKHIVGIACGPA---------QSFAWSSCSEWSIGL 786
Q KPE LD ++IV ++CG A Q +AW S+ +GL
Sbjct: 64 GQLGHEKSRKKPEQVV--ALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
>gi|157738609 HECT domain containing 3 [Homo sapiens]
Length = 861
Score = 186 bits (473), Expect = 4e-46
Identities = 120/339 (35%), Positives = 184/339 (54%), Gaps = 21/339 (6%)
Query: 4466 WKVKFVGESVDDCGGGYSESIAEICEELQNGLT------PLLIVTPNGRDESGANRDCYL 4519
W+ KF+ E + D GGG+ +S+A++ EEL P + T N + +G RD Y+
Sbjct: 528 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYV 587
Query: 4520 LSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIA-DLSEVDKD 4578
+P+ R + + ++G L+G A+R L L L VWKQL+G ++ + D VD
Sbjct: 588 PNPSCR---DFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSV 644
Query: 4579 FIPGLMYIRDNEATSEEFE-AMSLPFTVPSASGQDIQLSSKHTHITLD--NRAEYVRLAI 4635
+ L + + + EF+ L FT + Q ++L I + +R+ +++L
Sbjct: 645 LVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQ 704
Query: 4636 NYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIE 4695
RL E EQVAA++ G+ +VVP +L L T ELE VCG P++ + L+ + ++ E
Sbjct: 705 KARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFE 764
Query: 4696 PSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHF 4755
PS S +Q+FWE + +F+N +RS FLRFV GR+RLP R ++ Y D
Sbjct: 765 PSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLP-------ARIYIYPDKLGYETTD-A 816
Query: 4756 LPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTD 4794
LPES TC L LP Y+ +V EEKL+YA + C +IDTD
Sbjct: 817 LPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855
Score = 76.6 bits (187), Expect = 5e-13
Identities = 49/133 (36%), Positives = 77/133 (57%), Gaps = 5/133 (3%)
Query: 2779 LDSWSRMVKSLNVSSSVNQ--ASRLIDGS-EPCWQSSGSQGKHWIRLEIFPDVLVHRLKM 2835
L S + V+S++VSS + S L D + + W+S GSQ +HW+RL + +V +L +
Sbjct: 237 LGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLL 296
Query: 2836 IVDPADSSYMPSLVVVSGGNSLNNLIELKTININPS-DTTVPLLNDCTEYHRYIEIAIKQ 2894
VD D ++MP VVV GG +NL +L ++I+ + V +L D T + IEI I +
Sbjct: 297 TVDTTDDNFMPKRVVVYGGEG-DNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVE 355
Query: 2895 CRSSGIDCKIHGL 2907
CR GID ++ G+
Sbjct: 356 CRDDGIDVRLRGV 368
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 178 bits (452), Expect = 1e-43
Identities = 125/346 (36%), Positives = 181/346 (52%), Gaps = 13/346 (3%)
Query: 2964 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYACGEATNG 3022
W L L+G + P +S +V +VA GG+ S+F + +G+VY CG T G
Sbjct: 7 WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGNHSVFLLE-DGEVYTCGLNTKG 64
Query: 3023 RLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 3082
+LG P QI AL+ + VA G H+ AL+ G++FSWG G DG+LG
Sbjct: 65 QLGHEREGNK---PEQIGALADQHIIHVAC--GESHSLALSDRGQLFSWGAGSDGQLGLM 119
Query: 3083 SRMNCDK-PRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQL 3140
+ + PRLI+ L + I ++CG+ H AL + G+ +TWG +G+LG G +Q
Sbjct: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179
Query: 3141 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 3200
P+ V+ L G + QVA G A + AL+ G VF WG + G+LG + P +++
Sbjct: 180 SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVK 237
Query: 3201 RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260
L Q V I CG + + LTKSG V+T+G G +LGH S P+ V L G ++
Sbjct: 238 LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVT 297
Query: 3261 HVAVGALHCLA-VTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG 3305
+A G H LA V SG +YA+G GQ G G T + P+ V+G
Sbjct: 298 QIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
Score = 167 bits (423), Expect = 2e-40
Identities = 105/314 (33%), Positives = 164/314 (52%), Gaps = 10/314 (3%)
Query: 4010 GYGAGGRLGIGGTES--VSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
GY + G+ GI V+ P + I +K+VA GG H + L +GEVY+ G
Sbjct: 5 GYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVAC--GGNHSVFLLEDGEVYTCGLNT 62
Query: 4068 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127
G+LGH ++P I +L ++ VA G +HS ++ G L++WG G G+LG
Sbjct: 63 KGQLGHEREG--NKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 4128 SEDQLK-PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK 4186
+ED + P+L++ L ++ ++CG+ L L D ++WG +G+LG G +
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQ 178
Query: 4187 V-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245
P ++ SL G+ + +V G S AL+ SGAV+ WG + +LG + P V+
Sbjct: 179 ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKL 238
Query: 4246 LQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNR 4305
L+ +KV+ I+ G H T+ G V+T+G GQLG + N PR V L G +V +
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQ 298
Query: 4306 VACGSAHTLAWSTS 4319
+ACG HTLA+ S
Sbjct: 299 IACGRQHTLAFVPS 312
Score = 164 bits (416), Expect = 2e-39
Identities = 105/303 (34%), Positives = 159/303 (52%), Gaps = 11/303 (3%)
Query: 3027 GISS---GTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFS 3083
GIS+ G V P+ +S VK+VA GG H+ L DG+V++ G G+LGH
Sbjct: 13 GISTNLQGIVAEPQVCGFISDRSVKEVAC--GGNHSVFLLEDGEVYTCGLNTKGQLGHER 70
Query: 3084 RMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLK-P 3142
N KP I AL + I +ACG SHS AL+ G+L++WG G G+LG + P
Sbjct: 71 EGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVP 128
Query: 3143 KMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNI-PQNIER 3201
++++ L ++QV+CG+ LAL +G F+WG G+LG G PQ +
Sbjct: 129 RLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS 186
Query: 3202 LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVH 3261
L G + Q+ G S AL+ SG V+ WG + +LG + P V+ LR +K+V+
Sbjct: 187 LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVY 246
Query: 3262 VAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3321
++ G H +T SG V+ +G GQ G+ + P V L G ++T++ACG H+
Sbjct: 247 ISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHT 306
Query: 3322 VAW 3324
+A+
Sbjct: 307 LAF 309
Score = 164 bits (416), Expect = 2e-39
Identities = 106/298 (35%), Positives = 166/298 (55%), Gaps = 11/298 (3%)
Query: 3952 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
G +Y G N +GQLG EG K P ALA + + GE A++ G+L++ G
Sbjct: 53 GEVYTCGLNTKGQLGHEREGNK---PEQIGALADQHIIHVACGESHSLALSDRGQLFSWG 109
Query: 4011 YGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4069
G+ G+LG+ TE SV+ P L++ + I + V+ G HCLAL+++G+ ++WG+ G
Sbjct: 110 AGSDGQLGLMTTEDSVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 167
Query: 4070 KLGHGNRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4128
+LG G P P+ + SL GI + VAAGGAHS ++ +G ++ WG G+LG SD
Sbjct: 168 QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 227
Query: 4129 EDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVP 4188
+D+ P V+ L+ +VV I+CG + T LT V+++G G G+LG + P
Sbjct: 228 KDRESPCHVKLLRTQKVVYISCG--EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNP 285
Query: 4189 MKIDSLTGLGVVKVECGSQFSVA-LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245
++ L G V ++ CG Q ++A + SG +Y +G G +LG G +V+ P V+G
Sbjct: 286 RRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
Score = 156 bits (395), Expect = 4e-37
Identities = 90/259 (34%), Positives = 136/259 (52%), Gaps = 8/259 (3%)
Query: 3071 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128
WG G+ G + + +P++ + + ++++ACG +HS L GE+YT GL
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
G+LGH KP+ + L +I VACG ++ +LAL+D G +FSWG G G+LG
Sbjct: 64 GQLGHEREGN--KPEQIGALADQHIIHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 119
Query: 3189 GSE-GCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3246
+E +P+ I++LN Q + Q+ CG LAL G +TWGK + +LG G + +
Sbjct: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179
Query: 3247 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306
PQ V L G + VA G H A++ SG V+ WG N+ GQ G P V+ L
Sbjct: 180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLL 239
Query: 3307 EGQKITRVACGSSHSVAWT 3325
QK+ ++CG H+ T
Sbjct: 240 RTQKVVYISCGEEHTAVLT 258
Score = 152 bits (383), Expect = 1e-35
Identities = 108/344 (31%), Positives = 165/344 (47%), Gaps = 17/344 (4%)
Query: 3957 WGHNHRGQLG---GIEGAKVKVPTPCEALATLRPVQLI--GGEQTLFAVTADGKLYATGY 4011
WG+ GQ G ++G V P C ++ R V+ + GG ++F + DG++Y G
Sbjct: 4 WGYWSLGQPGISTNLQGI-VAEPQVCGFISD-RSVKEVACGGNHSVFLLE-DGEVYTCGL 60
Query: 4012 GAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKL 4071
G+LG + + QH+ + V G H LALS G+++SWG DG+L
Sbjct: 61 NTKGQLGHEREGNKPEQIGALADQHI----IHVACGESHSLALSDRGQLFSWGAGSDGQL 116
Query: 4072 G-HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-HSDSE 4129
G PR+I+ L ++ V+ G H + A G +TWGK +G+LG +
Sbjct: 117 GLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFP 176
Query: 4130 DQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPM 4189
Q P+ V +L+G + +A G A + L+ V+ WG + G+LG + P
Sbjct: 177 SQASPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPC 234
Query: 4190 KIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGK 4249
+ L VV + CG + + LTKSG V+T+G G +LGH S + PR+V L G
Sbjct: 235 HVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGS 294
Query: 4250 KVIAIATGSLHCVCCT-EDGEVYTWGDNDEGQLGDGTTNAIQRP 4292
+V IA G H + G +Y +G GQLG G T ++ P
Sbjct: 295 EVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338
Score = 145 bits (367), Expect = 7e-34
Identities = 93/326 (28%), Positives = 160/326 (49%), Gaps = 19/326 (5%)
Query: 439 VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 490
V P C +++ V ++AC + L +G VYT N+ + P+ + L
Sbjct: 22 VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 81
Query: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 550
A ++I+ +A H LAL+ G+++SWG G G+LG T E+ + K
Sbjct: 82 ADQHIIHVACGES--HSLALSDRGQLFSWGAGSDGQLGLMTT---EDSVAVPRLIQKLNQ 136
Query: 551 KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 609
+ ++ ++CG+ + A+ A+G+ +TWG+ ++G+LG G +A P V L+G+ + VA
Sbjct: 137 QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 196
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
G A + A++ +G V+ WG + G+LG ++P ++ L+ VV + CG + +
Sbjct: 197 AGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHT 254
Query: 670 IALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSE 729
LTK G V+++G G +LGH + P+ + L G +V +A G H LA S
Sbjct: 255 AVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSG 314
Query: 730 V---HSWGSNDQCQHFDTLRVTKPEP 752
+ G+ Q T V P P
Sbjct: 315 LIYAFGCGARGQLGTGHTCNVKCPSP 340
Score = 141 bits (356), Expect = 1e-32
Identities = 80/244 (32%), Positives = 140/244 (57%), Gaps = 8/244 (3%)
Query: 2954 AATIRTKVFVWGLNDKDQLGGLKGS-KIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
A + R ++F WG QLG + + VP + L+ ++QV+ G+ A+ +G+
Sbjct: 98 ALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ 157
Query: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
+ G+ ++G+LGLG + P+++ +L + +VA +GG H+ AL++ G VF WG
Sbjct: 158 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWG 215
Query: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
+ G+LG + + P ++ L+T+++ I+CG H+A LT SG ++T+G G G+LG
Sbjct: 216 MNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG 275
Query: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLA-LTDEGLVFSWGDGDFGKLGRGGSE 3191
H ++ P+ V L+G V Q+ACG + TLA + GL++++G G G+LG G +
Sbjct: 276 HDSMNDEVNPRRVLELMGSEVTQIACGRQ--HTLAFVPSSGLIYAFGCGARGQLGTGHT- 332
Query: 3192 GCNI 3195
CN+
Sbjct: 333 -CNV 335
Score = 124 bits (312), Expect = 2e-27
Identities = 79/277 (28%), Positives = 140/277 (50%), Gaps = 21/277 (7%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490
P Q LA+ + +AC E L LS G++++ SD P+L+Q L
Sbjct: 75 PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKL 134
Query: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 549
+ I++++ + H LALAA G+ ++WG G+LG G P + P+ + + G
Sbjct: 135 NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 191
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
+ +A G +S A++ G ++ WG N G+LG +D P V L+ KV+ ++
Sbjct: 192 ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYIS 248
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
CG + T +T++G V+++G G G+LG + P+ + +L +V ++ CG Q +
Sbjct: 249 CG--EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHT 306
Query: 670 IALT-KDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG 705
+A G +Y++G G +LG G +V+ P ++G
Sbjct: 307 LAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
Score = 121 bits (303), Expect = 2e-26
Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 5/249 (2%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGA-KVKVPTPCEALATLRPVQLIGGEQTLFAVTAD 4003
+L+ G ++ WG GQLG + V VP + L +Q+ G A+ AD
Sbjct: 96 SLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 155
Query: 4004 GKLYATGYGAGGRLGIGGT-ESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4062
G+ + G + G+LG+G S ++P + S++ + + +VA +GG H ALS G V+
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFG 213
Query: 4063 WGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGR 4122
WG G+LG + + P ++ LR +VV ++ G H+A +T +G ++T+G G G+
Sbjct: 214 WGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273
Query: 4123 LGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGS 4182
LGH D++ P+ V L G V IACG + ++++G G G+LG G +
Sbjct: 274 LGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAF-VPSSGLIYAFGCGARGQLGTGHT 332
Query: 4183 DGCKVPMKI 4191
K P +
Sbjct: 333 CNVKCPSPV 341
Score = 94.7 bits (234), Expect = 2e-18
Identities = 85/326 (26%), Positives = 136/326 (41%), Gaps = 23/326 (7%)
Query: 4467 KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA 4526
KV F GE D GG E + +EL N + + +D LL +
Sbjct: 732 KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYY----------QDSNLLWFSDTC 781
Query: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
V + F +G+ G+AI + + L+ ++K+L + + DL E+ L +
Sbjct: 782 FVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL 841
Query: 4587 RDNEATSEEFEAMSLPFTVPSASGQDIQLSS-----KHTHITLDNRAEYVRLAINYRLH- 4640
D E E L FT+ S I+ + + DNR E+V +NY
Sbjct: 842 LDYPGEDVE-ETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI 900
Query: 4641 EFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSAS 4699
E A G +V +L LF EL M+ G+ + L+ A YKG +
Sbjct: 901 SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP 960
Query: 4700 LIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPES 4759
++ FWE F ++ FL F+ G R+P G + V+ + +LP +
Sbjct: 961 TVKLFWETFHEFPLEKKKKFLLFLTGSDRIP-----IYGMASLQIVIQSTASGEEYLPVA 1015
Query: 4760 YTCFFLLKLPRYSCKQVLEEKLKYAI 4785
+TC+ LL LP+YS K++L +L A+
Sbjct: 1016 HTCYNLLDLPKYSSKEILSARLTQAL 1041
Score = 57.8 bits (138), Expect = 3e-07
Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 13/166 (7%)
Query: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
SG ++GWG N+ GQLG + + P + L T + V + GE+ +T G ++ G
Sbjct: 208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFG 267
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLA-LSSEGEVYSWGEAEDG 4069
G+ G+LG P + + + ++A G +H LA + S G +Y++G G
Sbjct: 268 AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA--CGRQHTLAFVPSSGLIYAFGCGARG 325
Query: 4070 KLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4115
+LG G+ P ++ AHS ++A D + +
Sbjct: 326 QLGTGHTCNVKCPSPVKGY----------WAAHSGQLSARADRFKY 361
Score = 48.5 bits (114), Expect = 2e-04
Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 16/142 (11%)
Query: 425 VIGWGL-----IGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS 479
V GWG+ +G + P + L V I+C E+ +L+++G V+T S
Sbjct: 211 VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGS 270
Query: 480 ----------DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH 529
D + P+ V L + +IA H + ++G +Y++GCG G+LG
Sbjct: 271 CGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQ-HTLAFVPSSGLIYAFGCGARGQLGT 329
Query: 530 GDTVPLEEPKVISAFSGKQAGK 551
G T ++ P + + +G+
Sbjct: 330 GHTCNVKCPSPVKGYWAAHSGQ 351
Score = 46.6 bits (109), Expect = 6e-04
Identities = 30/99 (30%), Positives = 48/99 (48%), Gaps = 11/99 (11%)
Query: 697 VRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALP 756
V P++ + + V +VA G H + L ED EV++ G N + Q KPE +
Sbjct: 22 VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQ--IG 79
Query: 757 GLDTKHIVGIACGPAQS---------FAWSSCSEWSIGL 786
L +HI+ +ACG + S F+W + S+ +GL
Sbjct: 80 ALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118
>gi|239745529 PREDICTED: hypothetical protein XP_002343479 [Homo
sapiens]
Length = 138
Score = 171 bits (432), Expect = 2e-41
Identities = 90/108 (83%), Positives = 95/108 (87%)
Query: 280 SIPLQDQHLALAILLELAVQRGTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLP 339
S+PLQDQHLALAILLELAVQRGTLSQMLSAILLLLQLWDS AQETDNERSAQGTS LL
Sbjct: 19 SMPLQDQHLALAILLELAVQRGTLSQMLSAILLLLQLWDSRAQETDNERSAQGTSTLLLS 78
Query: 340 LLQRFQSIICRKDAPHSEGDMHLLSGPLSPNESFLRYLTLPQDNELAI 387
LLQ FQSIIC KD P SEG+MHLLSGPLSP+ESFLRYLTL + L +
Sbjct: 79 LLQTFQSIICGKDTPPSEGNMHLLSGPLSPSESFLRYLTLHKTTSLPL 126
>gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
Length = 3996
Score = 162 bits (411), Expect = 6e-39
Identities = 139/496 (28%), Positives = 227/496 (45%), Gaps = 57/496 (11%)
Query: 4338 LQEIPIIALRNRLLLLHHLSE-LFCPCIPMFDLEGSLDETGLGPSVGFDTLRGILISQGK 4396
L +PI +LR R LL L+ L +P+ +L + T ++ +G++ K
Sbjct: 3505 LLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAAL-LKEAKGLIFYDTK 3563
Query: 4397 EAAFRKVVQATMVRDRQHG-PVVELNRIQVKRSRSKGG------LAGPDGTKSVFGQMCA 4449
+V+ AT+ R H P + L+ +++ + A Q+C
Sbjct: 3564 VTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCV 3623
Query: 4450 KMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRD 4509
K++S G P + ++F GE V G + + ++C+ELQ+ LL++ P+
Sbjct: 3624 KLASGGD-----PTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAV 3678
Query: 4510 ESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSL-T 4568
N+ Y+L+P+ + FLG LLGIAIR PL L+L WK L G L
Sbjct: 3679 NK--NKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDP 3736
Query: 4569 IADLSEVDKDFIPGLMYIRDNEATSEEFEAMSL----------------------PFTVP 4606
DL E D I Y++ E+ ++E E +L FT
Sbjct: 3737 EQDLQEAD---ILTYNYVKKFESINDETELEALCAEIASQHLATESPDSPNKPCCRFTYL 3793
Query: 4607 SASGQDIQLSSKHTHITL--DNRAEYVRLAINYRLHEFD--EQVAAVREGMARVVPVPLL 4662
+ +G++++L S+ HI + +N+ Y + RL E E V AVR G+ ++P+ LL
Sbjct: 3794 TMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLL 3853
Query: 4663 SLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEPSASLIQWFWEVMESFSNTERSLFLR 4721
++ + E+E CG P I L LK+ Y+ G+ + I++FW +E F+ E F++
Sbjct: 3854 TMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIK 3913
Query: 4722 FVWGRTRLPRTIADFRGRDFVIQVLD---KYNPPDHFL--PES-----YTCFFLLKLPRY 4771
F + R+P T G V K PPD P+S TC F++KLP+Y
Sbjct: 3914 FACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQY 3973
Query: 4772 SCKQVLEEKLKYAIHF 4787
S +++ EKL+ AIH+
Sbjct: 3974 SSLEIMLEKLRCAIHY 3989
Score = 41.6 bits (96), Expect = 0.019
Identities = 20/49 (40%), Positives = 28/49 (57%)
Query: 3614 VESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVN 3662
VE+ HP D+ TV IPGA L + FD +CS++ +D L + G N
Sbjct: 637 VETVHPVRDNYKFKETVHIPGARCLYLRFDSRCSSQYDYDKLVIYAGPN 685
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 154 bits (389), Expect = 2e-36
Identities = 91/276 (32%), Positives = 140/276 (50%), Gaps = 8/276 (2%)
Query: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAA 3113
SG RH+ L + +V S G+ G+LG + P I+AL+T + ++CG HS A
Sbjct: 30 SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLA 89
Query: 3114 LTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG 3172
+ G ++ WG G G+LG G+ PK + L ++IQV+CG +LAL+ +
Sbjct: 90 VCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCG--HYHSLALSKDS 147
Query: 3173 LVFSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
VFSWG G+LG G PQ + L G + Q+ G S AL+ G + WG
Sbjct: 148 QVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS 207
Query: 3232 GDYFRL---GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQ 3288
+L G V KP V L+ +V+++ G H +T G+V+ +GDN GQ
Sbjct: 208 NSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 3289 QGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAW 3324
G T R P LV+ ++G ++++ CGS H++A+
Sbjct: 268 LGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAY 302
Score = 148 bits (373), Expect = 1e-34
Identities = 101/283 (35%), Positives = 149/283 (52%), Gaps = 17/283 (6%)
Query: 3958 GHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRL 4017
G N RGQLG + ++P P +AL TL + G++ AV G+++A G G+ G+L
Sbjct: 48 GDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQL 107
Query: 4018 GIGGTESVS-TPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4076
GIG + +S TP + ++ IK + V+ G H LALS + +V+SWG+ G+LG G
Sbjct: 108 GIGEFKEISFTPKKIMTLND--IKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE 165
Query: 4077 SPCD-RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL---GHSDSEDQL 4132
P P+ + SL GI + VAAGGAHS ++ G + WG G+L G +
Sbjct: 166 FPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSN 225
Query: 4133 KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4192
KP V AL+ VV I+C GDA T LT D V+++GD G+LG + + P ++
Sbjct: 226 KPLSVGALKNLGVVYISC--GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVE 283
Query: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDD 4235
+ GL V +++CGS ++A Y G GHG D
Sbjct: 284 RIDGL-VSQIDCGSYHTLA-------YVHTTGQVVSFGHGPSD 318
Score = 144 bits (364), Expect = 2e-33
Identities = 94/291 (32%), Positives = 145/291 (49%), Gaps = 10/291 (3%)
Query: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSAC 4105
SG +H L L + V S G+ G+LG + P I++L + V V+ G HS
Sbjct: 30 SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLA 89
Query: 4106 VTAAGDLYTWGKGRYGRLGHSD-SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDD 4164
V G ++ WG G G+LG + E PK + L +++ ++CG +L L+ D
Sbjct: 90 VCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGH--YHSLALSKDS 147
Query: 4165 TVWSWGDGDYGKLGRGGSDGCKV-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4223
V+SWG +G+LG G + P ++ SL G+ + +V G S AL+ G + WG
Sbjct: 148 QVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS 207
Query: 4224 GDYHRL---GHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQ 4280
+L G +P V L+ V+ I+ G H T+DG+V+T+GDN GQ
Sbjct: 208 NSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 4281 LGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAW--STSKPASAGKLPA 4329
LG T + P+LV + G V+++ CGS HTLA+ +T + S G P+
Sbjct: 268 LGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGPS 317
Score = 130 bits (326), Expect = 4e-29
Identities = 95/302 (31%), Positives = 154/302 (50%), Gaps = 12/302 (3%)
Query: 2938 GNSGSLIRKKAAGLESAATIRT--KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVV 2995
G+ G+ + + A+G + + T +V G N + QLG + ++P + L L V
Sbjct: 19 GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD 78
Query: 2996 QVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSG 3055
V+ G + AV +G+V+A G + G+LG+G P++I L+ +K + V G
Sbjct: 79 LVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLND--IKIIQVSCG 136
Query: 3056 GRHATALTVDGKVFSWGEGDDGKLGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAAL 3114
H+ AL+ D +VFSWG+ G+LG P+ + +L+ + +A G +HS AL
Sbjct: 137 HYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Query: 3115 TSSGELYTWGLGEYGRL---GHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDE 3171
+ G + WG G+L G KP V L V+ ++CG DA T LT +
Sbjct: 197 SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG--DAHTAVLTQD 254
Query: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLA-LTKSGVVWTWG 3230
G VF++GD G+LG + PQ +ER++G V QI+CG+ +LA + +G V ++G
Sbjct: 255 GKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG 313
Query: 3231 KG 3232
G
Sbjct: 314 HG 315
Score = 124 bits (310), Expect = 3e-27
Identities = 80/293 (27%), Positives = 147/293 (50%), Gaps = 11/293 (3%)
Query: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSG 4047
+Q GE+ + + ++ + G + G+LG G + P +++++ + + V+ G
Sbjct: 26 LQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD--LVSCG 83
Query: 4048 GKHCLALSSEGEVYSWGEAEDGKLGHGN-RSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106
+H LA+ +G V++WG +G+LG G + P+ I +L I+++ V+ G HS +
Sbjct: 84 KEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
Query: 4107 TAAGDLYTWGKGRYGRLG-HSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
+ +++WGK +G+LG + Q P+ V +L+G + +A +G A + L+ T
Sbjct: 144 SKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLCGT 201
Query: 4166 VWSWGDGDYGKL---GRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWG 4222
+ WG G+L GR P+ + +L LGVV + CG + LT+ G V+T+G
Sbjct: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Query: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTE-DGEVYTWG 4274
+LG+ R P+ V+ + G V I GS H + G+V ++G
Sbjct: 262 DNRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 119 bits (298), Expect = 7e-26
Identities = 88/313 (28%), Positives = 153/313 (48%), Gaps = 29/313 (9%)
Query: 455 QIACAEKRFLILSRNGRVYTQAYNSDTLA----------PQLVQGLASRNIVKIAAHSDG 504
Q A E+ L+L N RV + NS P+ +Q L + + ++ +
Sbjct: 27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE- 85
Query: 505 HHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQAGKHVVHIACGSTYS 563
H LA+ G V++WG G G+LG G+ + PK I + + ++ ++CG +S
Sbjct: 86 -HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK----IIQVSCGHYHS 140
Query: 564 AAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTE 622
A++ + ++++WG+ ++G+LG G +A P V L+G+ + VA G A + A++
Sbjct: 141 LALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG--AHSFALSL 198
Query: 623 NGQVWSWGDGDYGKLGRGGSD---GCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 679
G + WG G+L G + P + L++L VV + CG + LT+DG+V+
Sbjct: 199 CGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVF 258
Query: 680 SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS-EVHSWGSNDQ 738
++G + +LG+ R P+L+E + G V + GS H LA + +V S+G
Sbjct: 259 TFGDNRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGPS 317
Query: 739 CQHFDTLRVTKPE 751
DT + T PE
Sbjct: 318 ----DTSKPTHPE 326
Score = 112 bits (281), Expect = 7e-24
Identities = 74/229 (32%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
G ++ A G +S + + + G + G+LG ++ +P + L+ L V V+
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKVRCGSQF 668
CG +LAV G+V++WG G G+LG G + TPK I L D+ +++V CG
Sbjct: 82 CGK--EHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
Query: 669 SIALTKDGQVYSWGKGDNQRLGHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED 727
S+AL+KD QV+SWGK + +LG G E P+ + L+G + VAAG H AL+
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
Query: 728 SEVHSWGSNDQCQ---HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQS 773
WGSN Q + V +P ++ L +V I+CG A +
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Score = 109 bits (273), Expect = 6e-23
Identities = 71/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQ 3164
A G HS L ++ + + G G+LG P+ ++ L V V+CG
Sbjct: 29 ASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE--H 86
Query: 3165 TLALTDEGLVFSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFSLALTKS 3223
+LA+ +G VF+WG G G+LG G + + P+ I LN + Q+ CG SLAL+K
Sbjct: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
Query: 3224 GVVWTWGKGDYFRLGHGSDVHVR-KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282
V++WGK + +LG G + + PQ V L G + VA G H A++ G + WG
Sbjct: 147 SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWG 206
Query: 3283 DNDHGQ---QGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
N GQ G + KP V L+ + ++CG +H+ T
Sbjct: 207 SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLT 252
Score = 107 bits (268), Expect = 2e-22
Identities = 69/229 (30%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 4090 GIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIA 4149
G E++ A+G HS + + + G G+LG ++ P+ ++AL+ V ++
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 4150 CGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGG-SDGCKVPMKIDSLTGLGVVKVECGSQF 4208
CG + +C V++WG G G+LG G + P KI +L + +++V CG
Sbjct: 82 CGKEHSLAVC--HKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
Query: 4209 SVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTED 4267
S+AL+K V++WGK + +LG G + P++V+ L+G + +A G H +
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
Query: 4268 GEVYTWGDNDEGQLG-DGTTNAIQ--RPRLVAALQGKKVNRVACGSAHT 4313
G + WG N GQL G +Q +P V AL+ V ++CG AHT
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Score = 103 bits (258), Expect = 3e-21
Identities = 65/212 (30%), Positives = 106/212 (50%), Gaps = 13/212 (6%)
Query: 4148 IACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQ 4207
+ SG+ +L L + V S GD G+LGR G+ ++P I +L L V V CG +
Sbjct: 26 LQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE 85
Query: 4208 FSVALTKSGAVYTWGKGDYHRLGHGSDDHVR-RPRQVQGLQGKKVIAIATGSLHCVCCTE 4266
S+A+ G V+ WG G +LG G + P+++ L K+I ++ G H + ++
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSK 145
Query: 4267 DGEVYTWGDNDEGQLGDGTTNAIQ-RPRLVAALQGKKVNRVACGSAHTLA---------W 4316
D +V++WG N GQLG G Q P+ V +L+G + +VA G AH+ A W
Sbjct: 146 DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGW 205
Query: 4317 STSKPASAGKLPAQVPMEYNHLQEIPIIALRN 4348
++ VP++ N + + + AL+N
Sbjct: 206 GSNSAGQLALSGRNVPVQSN--KPLSVGALKN 235
Score = 103 bits (257), Expect = 4e-21
Identities = 77/260 (29%), Positives = 129/260 (49%), Gaps = 27/260 (10%)
Query: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490
P + L L V ++C ++ L + GRV+ S+ + P+ + L
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTL 125
Query: 491 ASRNIVKIAAHSDGH-HYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQ 548
N +KI S GH H LAL+ +V+SWG G+LG G P + P+ + + G
Sbjct: 126 ---NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP 182
Query: 549 AGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRL---GHGSSEDEAIPMLVAGLKGLKV 605
+ +A G +S A++ G + WG + G+L G P+ V LK L V
Sbjct: 183 ----LAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGV 238
Query: 606 IDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCG 665
+ ++C GDA T +T++G+V+++GD G+LG + + P+L+E++ L V ++ CG
Sbjct: 239 VYISC--GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCG 295
Query: 666 SQFSIA-LTKDGQVYSWGKG 684
S ++A + GQV S+G G
Sbjct: 296 SYHTLAYVHTTGQVVSFGHG 315
Score = 102 bits (255), Expect = 7e-21
Identities = 66/196 (33%), Positives = 102/196 (52%), Gaps = 4/196 (2%)
Query: 586 GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 645
G+ E AG G +++ A SG+ +L + N +V S GD G+LGR G+
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAA--SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRG 63
Query: 646 KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRY-PKLLE 704
+ P+ I+ L+ L V V CG + S+A+ G+V++WG G +LG G + + + PK +
Sbjct: 64 ELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM 123
Query: 705 GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKPEPAALPGLDTKHI 763
L K+I V+ G H LAL++DS+V SWG N Q ++ P + L+ +
Sbjct: 124 TLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 183
Query: 764 VGIACGPAQSFAWSSC 779
+A G A SFA S C
Sbjct: 184 AQVAAGGAHSFALSLC 199
Score = 100 bits (249), Expect = 4e-20
Identities = 64/213 (30%), Positives = 115/213 (53%), Gaps = 8/213 (3%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVK-VPTPCEALATLRPVQLIGGEQTLFAVTAD 4003
+L+ G ++ WG GQLG E ++ P L ++ +Q+ G A++ D
Sbjct: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
Query: 4004 GKLYATGYGAGGRLGIGGT-ESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4062
++++ G + G+LG+G S ++P + S++ + + +VA +GG H ALS G +
Sbjct: 147 SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLCGTSFG 204
Query: 4063 WGEAEDGKLGHGNRS---PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGR 4119
WG G+L R+ ++P + +L+ + VV ++ G AH+A +T G ++T+G R
Sbjct: 205 WGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNR 264
Query: 4120 YGRLGHSDSEDQLKPKLVEALQGHRVVDIACGS 4152
G+LG+S + ++ P+LVE + G V I CGS
Sbjct: 265 SGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGS 296
Score = 89.4 bits (220), Expect = 8e-17
Identities = 71/234 (30%), Positives = 115/234 (49%), Gaps = 29/234 (12%)
Query: 418 HKGSLQEVIGWGL-----IGWKYYANV-IGPIQCEGLANLGVTQIACAEKRFLILSRNGR 471
HKG V WG +G + + P + L ++ + Q++C L LS++ +
Sbjct: 92 HKG---RVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQ 148
Query: 472 VYTQAYNS-----------DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWG 520
V++ NS +PQ V+ L + ++AA G H AL+ G + WG
Sbjct: 149 VFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA--GGAHSFALSLCGTSFGWG 206
Query: 521 CGDGGRLG-HGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGN 579
G+L G VP++ K +S + K G VV+I+CG ++A +T +G+++T+G
Sbjct: 207 SNSAGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNR 264
Query: 580 YGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLA-VTENGQVWSWGDG 632
G+LG+ + ++ P LV + GL V + CGS TLA V GQV S+G G
Sbjct: 265 SGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGS--YHTLAYVHTTGQVVSFGHG 315
Score = 81.3 bits (199), Expect = 2e-14
Identities = 87/330 (26%), Positives = 145/330 (43%), Gaps = 26/330 (7%)
Query: 4464 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPA 4523
+V V+F+ E + GG SE + EE+ + + G C + PA
Sbjct: 699 KVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG--------SC-MWFPA 749
Query: 4524 ARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGL 4583
P F F G+L G+++ + +L ++K+L ++ DL E+ L
Sbjct: 750 KPKPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808
Query: 4584 MYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLD--NRAEYVRLAINYRLHE 4641
+ D +A + +A+ + F++ D+ L I +D N+ +YV I+Y
Sbjct: 809 QEVLD-DAADDIGDALCIRFSI-HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYI--- 863
Query: 4642 FDEQVAAVRE----GMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEP 4696
F+ V AV E G RV +L F EL T + G+ D + + Y+ G +
Sbjct: 864 FNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQK 923
Query: 4697 SASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFL 4756
S IQ FW+ + E+ FL F+ GR RL + + V + + ++ DH
Sbjct: 924 SHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHAR--GIQKMEIVFRCPETFSERDH-- 979
Query: 4757 PESYTCFFLLKLPRYSCKQVLEEKLKYAIH 4786
P S TC +L LP+YS + +EE L+ AI+
Sbjct: 980 PTSITCHNILSLPKYSTMERMEEALQVAIN 1009
Score = 58.5 bits (140), Expect = 2e-07
Identities = 42/162 (25%), Positives = 67/162 (41%), Gaps = 14/162 (8%)
Query: 4196 GLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIA 4255
G +++ G + S+ L + V + G +LG P +Q L+ V ++
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 4256 TGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQ-RPRLVAALQGKKVNRVACGSAHTL 4314
G H + G V+ WG EGQLG G I P+ + L K+ +V+CG H+L
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 4315 A---------WSTSKPASAG---KLPAQV-PMEYNHLQEIPI 4343
A W + G + P+Q P L+ IP+
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 183
Score = 54.3 bits (129), Expect = 3e-06
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Query: 3204 GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVA 3263
G + Q G + SL L + V + G +LG P+ ++ L + V+
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 3264 VGALHCLAVTDSGQVYAWGDNDHGQQGNGT-TTVNRKPTLVQGLEGQKITRVACGSSHSV 3322
G H LAV G+V+AWG GQ G G ++ P + L KI +V+CG HS+
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 3323 A 3323
A
Sbjct: 142 A 142
Score = 48.1 bits (113), Expect = 2e-04
Identities = 26/84 (30%), Positives = 42/84 (50%)
Query: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4291
G+D + R+ G G +++ A+G H + + V + GDN GQLG +
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 4292 PRLVAALQGKKVNRVACGSAHTLA 4315
P + AL+ V+ V+CG H+LA
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLA 89
Score = 44.3 bits (103), Expect = 0.003
Identities = 25/84 (29%), Positives = 39/84 (46%)
Query: 3240 GSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRK 3299
G+D + + G G +++ A G H L + + +V + GDN GQ G
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 3300 PTLVQGLEGQKITRVACGSSHSVA 3323
P +Q LE + V+CG HS+A
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLA 89
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 151 bits (381), Expect = 2e-35
Identities = 96/276 (34%), Positives = 143/276 (51%), Gaps = 5/276 (1%)
Query: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS-HSA 3112
S G TV+ ++F G G LG + +PR +++L K+I ++ GS H
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
Query: 3113 ALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHR-VIQVACGSRDAQTLALTDE 3171
T+ GE++TWG Y +LG+G L P + L ++ VI+VACGS +L LT +
Sbjct: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSY--HSLVLTSD 170
Query: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFSLALTKSGVVWTWG 3230
G VF+WG + G++G G + IP+ + L + V I CG +A+ +G V+ WG
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 3231 KGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
+LG G+ + P V L+G ++ VA G H L +TD GQVYAWG N +GQ G
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 3291 NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
G + PT V + + I AC S+H+ A T
Sbjct: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
Score = 146 bits (368), Expect = 6e-34
Identities = 88/276 (31%), Positives = 137/276 (49%), Gaps = 5/276 (1%)
Query: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAG-GAHSA 4104
S G L + E++ G G LG G+ PR ++SL G ++ ++ G G H
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
Query: 4105 CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-LQGHRVVDIACGSGDAQTLCLTDD 4163
T G+++TWG Y +LG+ + L P + L +V+++ACGS +L LT D
Sbjct: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGS--YHSLVLTSD 170
Query: 4164 DTVWSWGDGDYGKLGRGGSDGCKVPMKIDS-LTGLGVVKVECGSQFSVALTKSGAVYTWG 4222
V++WG + G++G G + +P ++ L VV + CG +A+ +G VY WG
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
+LG G+ + P +V LQG +V +A G H + T++G+VY WG N GQLG
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 4283 DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWST 4318
G + P V + + + AC S HT A T
Sbjct: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
Score = 146 bits (368), Expect = 6e-34
Identities = 88/263 (33%), Positives = 142/263 (53%), Gaps = 13/263 (4%)
Query: 481 TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV 540
T+ P+ + L + I ++ + G H + GEV++WG +LG+G T V
Sbjct: 86 TIEPRRLDSLNGKKIACLS-YGSGPHIVLATTEGEVFTWGHNAYSQLGNGTT---NHGLV 141
Query: 541 ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG- 599
S + K V+ +ACGS +S +T++GE++ WG N G++G GS+ ++ IP V G
Sbjct: 142 PCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC 201
Query: 600 LKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDV 659
L+ V+ +ACG +AV + G+V+ WG G+LG G S TP + LQ + V
Sbjct: 202 LQNKVVVTIACGQ--MCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRV 259
Query: 660 VKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAA-GS 718
+V CG ++ LT +GQVY+WG +LG G + + YP + ++ ++I++AA S
Sbjct: 260 QRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT-VEKDRIIEIAACHS 318
Query: 719 TH-CLALTEDSEVHSWGSNDQCQ 740
TH A T+ V+ WG QC+
Sbjct: 319 THTSAAKTQGGHVYMWG---QCR 338
Score = 144 bits (362), Expect = 3e-33
Identities = 98/307 (31%), Positives = 151/307 (49%), Gaps = 23/307 (7%)
Query: 3980 EALATLRPVQLIG--GEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHV 4037
E L +R + G G + L+ T + +++ G G LG+G +S P L+S+
Sbjct: 40 EELQLIRQACVFGSAGNEVLYT-TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNG- 97
Query: 4038 FIKKVAVNS--GGKHCLALSSEGEVYSWGEAEDGKLGHGNRS----PCDRPRVIESLRGI 4091
KK+A S G H + ++EGEV++WG +LG+G + PC + +L
Sbjct: 98 --KKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPC---HISTNLSNK 152
Query: 4092 EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-LQGHRVVDIAC 4150
+V++VA G HS +T+ G+++ WG G++G + +Q P+ V LQ VV IAC
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212
Query: 4151 GSGDAQTLCLTDDDT--VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQF 4208
G Q C+ DT V+ WG G+LG G S P ++ +L G+ V +V CG
Sbjct: 213 G----QMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAH 268
Query: 4209 SVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCC-TED 4267
++ LT G VY WG Y +LG G+ + P V + + + A S H T+
Sbjct: 269 TLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQG 328
Query: 4268 GEVYTWG 4274
G VY WG
Sbjct: 329 GHVYMWG 335
Score = 141 bits (355), Expect = 2e-32
Identities = 95/290 (32%), Positives = 144/290 (49%), Gaps = 12/290 (4%)
Query: 2998 AGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAV--HSG 3055
+ G++ L+ TV +++ G G LGLG T+ PR++ +L+ KK+A +
Sbjct: 53 SAGNEVLYT-TVNDEIFVLGTNCCGCLGLGDVQSTIE-PRRLDSLNG---KKIACLSYGS 107
Query: 3056 GRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA-LKTKRIRDIACGSSHSAAL 3114
G H T +G+VF+WG +LG+ + + P I L K++ ++ACGS HS L
Sbjct: 108 GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVL 167
Query: 3115 TSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVI-QVACGSRDAQTLALTDEGL 3173
TS GE++ WG G++G G Q P+ V L ++V+ +ACG +A+ D G
Sbjct: 168 TSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCC--MAVVDTGE 225
Query: 3174 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGD 3233
V+ WG G+LG G S P + L G V ++ CG +L LT G V+ WG
Sbjct: 226 VYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANS 285
Query: 3234 YFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAV-TDSGQVYAWG 3282
Y +LG G+ + P V + + I A + H A T G VY WG
Sbjct: 286 YGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 132 bits (331), Expect = 1e-29
Identities = 80/245 (32%), Positives = 127/245 (51%), Gaps = 15/245 (6%)
Query: 502 SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIAC--- 558
S G+ L E++ G G LG GD EP+ + + +GK+ IAC
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKK-------IACLSY 105
Query: 559 -GSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVA-GLKGLKVIDVACGSGDAQ 616
+ T EGE++TWG Y +LG+G++ +P ++ L +VI+VACGS
Sbjct: 106 GSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGS--YH 163
Query: 617 TLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEK-LQDLDVVKVRCGSQFSIALTKD 675
+L +T +G+V++WG + G++G G + P+ + LQ+ VV + CG +A+
Sbjct: 164 SLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDT 223
Query: 676 GQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGS 735
G+VY WG N +LG G + P + LQG +V VA G H L LT++ +V++WG+
Sbjct: 224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA 283
Query: 736 NDQCQ 740
N Q
Sbjct: 284 NSYGQ 288
Score = 120 bits (300), Expect = 4e-26
Identities = 80/226 (35%), Positives = 119/226 (52%), Gaps = 6/226 (2%)
Query: 2955 ATIRTKVFVWGLNDKDQLGGLKGSKIKVPS-FSETLSALNVVQVAGGSKSLFAVTVEGKV 3013
AT +VF WG N QLG + VP S LS V++VA GS +T +G+V
Sbjct: 114 ATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEV 173
Query: 3014 YACGEATNGRLGLGISSGTVPIPRQITA-LSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
+A G +G++G G S+ PIPR++T L + VV V + G A+ G+V+ WG
Sbjct: 174 FAWGYNNSGQVGSG-STVNQPIPRRVTGCLQNKVV--VTIACGQMCCMAVVDTGEVYVWG 230
Query: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
+G+LG + N P + AL+ R++ +ACG +H+ LT G++Y WG YG+LG
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3178
G+ + Q P V V R+I++A + A T G V+ WG
Sbjct: 291 TGNKSNQSYPTPVTV-EKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 110 bits (276), Expect = 3e-23
Identities = 71/223 (31%), Positives = 107/223 (47%), Gaps = 9/223 (4%)
Query: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIG---GEQTLFAVTADGKLYA 4008
G ++ WGHN QLG G PC L Q+I G +T+DG+++A
Sbjct: 118 GEVFTWGHNAYSQLGN--GTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFA 175
Query: 4009 TGYGAGGRLGIGGTESVSTPTLLES-IQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
GY G++G G T + P + +Q+ + V + G C+A+ GEVY WG
Sbjct: 176 WGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV--VTIACGQMCCMAVVDTGEVYVWGYNG 233
Query: 4068 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127
+G+LG GN P + +L+GI V VA G AH+ +T G +Y WG YG+LG +
Sbjct: 234 NGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN 293
Query: 4128 SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWG 4170
+Q P V ++ R+++IA + T V+ WG
Sbjct: 294 KSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 94.7 bits (234), Expect = 2e-18
Identities = 66/224 (29%), Positives = 108/224 (48%), Gaps = 24/224 (10%)
Query: 424 EVIGWGLIGWKYYANVI---GPIQCE---GLANLGVTQIACAEKRFLILSRNGRVYTQAY 477
EV WG + N G + C L+N V ++AC L+L+ +G V+ Y
Sbjct: 119 EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178
Query: 478 NS----------DTLAPQLVQG-LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGR 526
N+ + P+ V G L ++ +V IA +A+ TGEVY WG G+
Sbjct: 179 NNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQ--MCCMAVVDTGEVYVWGYNGNGQ 236
Query: 527 LGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHG 586
LG G++ P ++A G + V +ACG ++ +T EG++Y WG +YG+LG G
Sbjct: 237 LGLGNSGNQPTPCRVAALQGIR----VQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292
Query: 587 SSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 630
+ +++ P V K ++I++A + A T+ G V+ WG
Sbjct: 293 NKSNQSYPTPVTVEKD-RIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 89.7 bits (221), Expect = 6e-17
Identities = 61/172 (35%), Positives = 86/172 (50%), Gaps = 5/172 (2%)
Query: 603 LKVIDVAC--GSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV 660
L++I AC GS + L T N +++ G G LG G P+ ++ L +
Sbjct: 42 LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIA 101
Query: 661 KVRCGSQFSIAL-TKDGQVYSWGKGDNQRLGHGTEEHVRYP-KLLEGLQGKKVIDVAAGS 718
+ GS I L T +G+V++WG +LG+GT H P + L K+VI+VA GS
Sbjct: 102 CLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGS 161
Query: 719 THCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPG-LDTKHIVGIACG 769
H L LT D EV +WG N+ Q V +P P + G L K +V IACG
Sbjct: 162 YHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACG 213
Score = 58.2 bits (139), Expect = 2e-07
Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 5/117 (4%)
Query: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCE--ALATLRPVQLIGGEQTLFAVTADGKLYA 4008
+G +Y WG+N GQLG G PTPC AL +R ++ G +T +G++YA
Sbjct: 223 TGEVYVWGYNGNGQLG--LGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYA 280
Query: 4009 TGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
G + G+LG G + S PT + +++ I ++A A + G VY WG+
Sbjct: 281 WGANSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 150 bits (379), Expect = 3e-35
Identities = 107/316 (33%), Positives = 155/316 (49%), Gaps = 30/316 (9%)
Query: 3031 GTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSW-----GEGDDGKLGHFSRM 3085
G + P ++ L++ VV+ V +G +T G++ W G G L +
Sbjct: 319 GGLGTPLRLPMLNTEVVQ---VAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLP--GAV 373
Query: 3086 NCDKP----RLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLK 3141
+P R +E I+ +ACG +A LT G + T+G G G LGHG T +
Sbjct: 374 EQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQ 433
Query: 3142 PKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 3201
P +V+ LLG+ ++QVACG+ + LAL+ E +F+WG GD G+LG G E + PQ +
Sbjct: 434 PTIVEALLGYEMVQVACGA--SHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPM 491
Query: 3202 LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG--HGS--DVHVRKPQVVEGLR-- 3255
GQ ++ CG S+ LT G G + +LG H S + V QV E L
Sbjct: 492 PPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551
Query: 3256 --------GKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 3307
+ ++ + +G H AVT SG Y +G N HGQ G T +R P VQGLE
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE 611
Query: 3308 GQKITRVACGSSHSVA 3323
G K+ VACG + +VA
Sbjct: 612 GIKMAMVACGDAFTVA 627
Score = 135 bits (340), Expect = 1e-30
Identities = 110/384 (28%), Positives = 169/384 (44%), Gaps = 39/384 (10%)
Query: 3953 TIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLY---AT 4009
++Y WG GG+ G +++P + VQ+ G VT G+L A
Sbjct: 313 SVYAWG-------GGL-GTPLRLP-----MLNTEVVQVAAGRTQKAGVTRSGRLILWEAP 359
Query: 4010 GYGAGGRLGIGGTESVSTPTL----LESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
GAGG + G P LE V IK VA CL + G + ++G
Sbjct: 360 PLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACL--TDRGIIMTFGS 417
Query: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGH 4125
+G LGHG+ + +P ++E+L G E+V VA G +H ++ +L+ WG+G GRLG
Sbjct: 418 GSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGL 477
Query: 4126 SDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4185
E P+ V G + CG ++ LT + G + KLG
Sbjct: 478 GTRESHSCPQQVPMPPGQEAQRVVCGID--SSMILTVPGQALACGSNRFNKLGLDHLSLG 535
Query: 4186 KVPM------KIDSLTGLG--------VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGH 4231
+ P+ + S T LG ++ ++ G+ S A+T SG YT+G + +LG
Sbjct: 536 EEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGT 595
Query: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNA-IQ 4290
+ R P +VQGL+G K+ +A G V + EVY+WG G+LG +A +
Sbjct: 596 NTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLP 655
Query: 4291 RPRLVAALQGKKVNRVACGSAHTL 4314
RP + V V+C +TL
Sbjct: 656 RPVQLDETHPYTVTSVSCCHGNTL 679
Score = 133 bits (334), Expect = 5e-30
Identities = 100/327 (30%), Positives = 148/327 (45%), Gaps = 36/327 (11%)
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070
Y GG LG TP L + + V V +G ++ G + W EA
Sbjct: 315 YAWGGGLG--------TPLRLPMLN---TEVVQVAAGRTQKAGVTRSGRLILW-EAPPLG 362
Query: 4071 LGHGNRSP--CDRP------RVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGR 4122
G G+ P ++P R +E G+ + VA G +AC+T G + T+G G G
Sbjct: 363 AGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGC 422
Query: 4123 LGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGS 4182
LGH D +P +VEAL G+ +V +ACG+ + L L+ + +++WG GD G+LG G
Sbjct: 423 LGHGSLTDISQPTIVEALLGYEMVQVACGA--SHVLALSTERELFAWGRGDSGRLGLGTR 480
Query: 4183 DGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG--HGSDDHVRRP 4240
+ P ++ G +V CG S+ LT G G +++LG H S P
Sbjct: 481 ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP 540
Query: 4241 RQV------------QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNA 4288
Q L + +++I G+ H T G+ YT+G N GQLG T
Sbjct: 541 HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG 600
Query: 4289 IQRPRLVAALQGKKVNRVACGSAHTLA 4315
+ P V L+G K+ VACG A T+A
Sbjct: 601 SRAPCKVQGLEGIKMAMVACGDAFTVA 627
Score = 132 bits (333), Expect = 6e-30
Identities = 109/379 (28%), Positives = 165/379 (43%), Gaps = 38/379 (10%)
Query: 2959 TKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 3018
+ V+ WG GGL G+ +++P + VVQVA G VT G++
Sbjct: 312 SSVYAWG-------GGL-GTPLRLPMLNT-----EVVQVAAGRTQKAGVTRSGRLILWEA 358
Query: 3019 ATNGRLGLGISSGTVPIP------RQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
G G + G V P R + S +K VA G LT G + ++G
Sbjct: 359 PPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVAC--GDFFTACLTDRGIIMTFG 416
Query: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
G +G LGH S + +P ++EAL + +ACG+SH AL++ EL+ WG G+ GRLG
Sbjct: 417 SGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLG 476
Query: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG 3192
G + P+ V + G +V CG ++ LT G + G F KLG
Sbjct: 477 LGTRESHSCPQQVPMPPGQEAQRVVCGI--DSSMILTVPGQALACGSNRFNKLGLDHLSL 534
Query: 3193 CNIP---QNIER-----------LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
P Q +E L+ + + I+ G S A+T SG +T+G + +LG
Sbjct: 535 GEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG 594
Query: 3239 HGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN- 3297
+ R P V+GL G K+ VA G +A+ +VY+WG G+ G
Sbjct: 595 TNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGL 654
Query: 3298 RKPTLVQGLEGQKITRVAC 3316
+P + +T V+C
Sbjct: 655 PRPVQLDETHPYTVTSVSC 673
Score = 123 bits (308), Expect = 5e-27
Identities = 85/281 (30%), Positives = 137/281 (48%), Gaps = 20/281 (7%)
Query: 524 GGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRL 583
GG L G V +P+ IS F Q+G + H+ACG ++A +T G + T+G G+ G L
Sbjct: 365 GGSLLPG-AVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCL 423
Query: 584 GHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSD 643
GHGS D + P +V L G +++ VACG+ + LA++ ++++WG GD G+LG G +
Sbjct: 424 GHGSLTDISQPTIVEALLGYEMVQVACGA--SHVLALSTERELFAWGRGDSGRLGLGTRE 481
Query: 644 GCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHG----TEEHVRY 699
P+ + + +V CG S+ LT GQ + G +LG EE V +
Sbjct: 482 SHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPH 541
Query: 700 PKLLEG----------LQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTK 749
++ E L + ++ + G+ H A+T + +++GSN Q R
Sbjct: 542 QQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGS 601
Query: 750 PEPAALPGLDTKHIVGIACGPAQSFAWSSCSE---WSIGLR 787
P + GL+ + +ACG A + A + SE W G R
Sbjct: 602 RAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGAR 642
Score = 111 bits (277), Expect = 2e-23
Identities = 76/272 (27%), Positives = 127/272 (46%), Gaps = 28/272 (10%)
Query: 446 EGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS----------DTLAPQLVQGLASRNI 495
EG + + + +AC + L+ G + T S D P +V+ L +
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 496 VKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVH 555
V++A + H LAL+ E+++WG GD GRLG G P+ + G++A +
Sbjct: 446 VQVACGAS--HVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQR---- 499
Query: 556 IACGSTYSAAITAEGELYTWGRGNYGRLG--HGSSEDEAIP------MLVAGLKGLKVID 607
+ CG S +T G+ G + +LG H S +E +P L L G +D
Sbjct: 500 VVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLD 559
Query: 608 ----VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVR 663
++ G A + AVT +G +++G +G+LG G + P ++ L+ + + V
Sbjct: 560 QEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVA 619
Query: 664 CGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE 695
CG F++A+ + +VYSWGKG RLG E+
Sbjct: 620 CGDAFTVAIGAESEVYSWGKGARGRLGRRDED 651
Score = 108 bits (271), Expect = 1e-22
Identities = 85/278 (30%), Positives = 128/278 (46%), Gaps = 19/278 (6%)
Query: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
D +T G I +G G LG + PT EAL VQ+ G + A++
Sbjct: 400 DFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALS 459
Query: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
+ +L+A G G GRLG+G ES S P + ++V G + L+ G+
Sbjct: 460 TERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVV--CGIDSSMILTVPGQAL 517
Query: 4062 SWGEAEDGKLGHGNRS----PCDRPRVIESLRGI----------EVVDVAAGGAHSACVT 4107
+ G KLG + S P +V E+L ++ + G AHSA VT
Sbjct: 518 ACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVT 577
Query: 4108 AAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVW 4167
A+GD YT+G ++G+LG + P V+ L+G ++ +AC GDA T+ + + V+
Sbjct: 578 ASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVAC--GDAFTVAIGAESEVY 635
Query: 4168 SWGDGDYGKLGRGGSD-GCKVPMKIDSLTGLGVVKVEC 4204
SWG G G+LGR D G P+++D V V C
Sbjct: 636 SWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
Score = 105 bits (263), Expect = 8e-22
Identities = 89/293 (30%), Positives = 139/293 (47%), Gaps = 22/293 (7%)
Query: 2937 KGNSGSLIRKKAAG--LESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNV 2994
+G SG I+ A G + T R + +G LG + I P+ E L +
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 2995 VQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHS 3054
VQVA G+ + A++ E +++A G +GRLGLG + + P+Q+ ++V
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDSGRLGLG-TRESHSCPQQVPMPPGQEAQRVV--C 502
Query: 3055 GGRHATALTVDGKVFSWGEGDDGKLG--HFSRMNCDKP--RLIEALK----------TKR 3100
G + LTV G+ + G KLG H S P ++ EAL +
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
Query: 3101 IRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
+ I G++HSAA+T+SG+ YT+G ++G+LG P V+ L G ++ VACG
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACG- 621
Query: 3161 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSE-GCNIPQNIERLNGQGVCQIEC 3212
DA T+A+ E V+SWG G G+LGR + G P ++ + V + C
Sbjct: 622 -DAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
Score = 98.6 bits (244), Expect = 1e-19
Identities = 79/238 (33%), Positives = 108/238 (45%), Gaps = 32/238 (13%)
Query: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3159
R R I G A +Y WG G LG T L+ M L V+QVA G
Sbjct: 294 RCRGIPRGPVRPAIPPPLSSVYAWG----GGLG-----TPLRLPM----LNTEVVQVAAG 340
Query: 3160 SRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER---------LNGQG---V 3207
Q +T G + W + LG GG G +P +E+ L GQ +
Sbjct: 341 R--TQKAGVTRSGRLILW---EAPPLGAGG--GSLLPGAVEQPQPQFISRFLEGQSGVTI 393
Query: 3208 CQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGAL 3267
+ CG F+ LT G++ T+G G LGHGS + +P +VE L G ++V VA GA
Sbjct: 394 KHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGAS 453
Query: 3268 HCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
H LA++ +++AWG D G+ G GT + P V GQ+ RV CG S+ T
Sbjct: 454 HVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILT 511
Score = 67.0 bits (162), Expect = 4e-10
Identities = 57/195 (29%), Positives = 87/195 (44%), Gaps = 42/195 (21%)
Query: 4165 TVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG 4224
+V++WG G LG P+++ L VV+V G +T+SG + W
Sbjct: 313 SVYAWGGG----LG--------TPLRLPMLN-TEVVQVAAGRTQKAGVTRSGRLILW--- 356
Query: 4225 DYHRLGHGSDD----HVRRP------RQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
+ LG G V +P R ++G G + +A G C T+ G + T+G
Sbjct: 357 EAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFG 416
Query: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKP------ASAGKL- 4327
G LG G+ I +P +V AL G ++ +VACG++H LA ST + +G+L
Sbjct: 417 SGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLG 476
Query: 4328 ---------PAQVPM 4333
P QVPM
Sbjct: 477 LGTRESHSCPQQVPM 491
Score = 65.5 bits (158), Expect = 1e-09
Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 22/161 (13%)
Query: 3174 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGD 3233
V++WG G P + LN + V Q+ G +T+SG + W +
Sbjct: 314 VYAWGGG------------LGTPLRLPMLNTE-VVQVAAGRTQKAGVTRSGRLILW-EAP 359
Query: 3234 YFRLGHGS----DVHVRKPQVV----EGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDND 3285
G GS V +PQ + EG G I HVA G +TD G + +G
Sbjct: 360 PLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGS 419
Query: 3286 HGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
+G G+G+ T +PT+V+ L G ++ +VACG+SH +A +T
Sbjct: 420 NGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALST 460
Score = 43.5 bits (101), Expect = 0.005
Identities = 28/103 (27%), Positives = 42/103 (40%)
Query: 2953 SAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
+A T + +G N QLG + P + L + + VA G A+ E +
Sbjct: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633
Query: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSG 3055
VY+ G+ GRLG +P P Q+ Y V V+ G
Sbjct: 634 VYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHG 676
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB (POZ)
domain containing protein 1 [Homo sapiens]
Length = 531
Score = 145 bits (366), Expect = 9e-34
Identities = 103/283 (36%), Positives = 141/283 (49%), Gaps = 15/283 (5%)
Query: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGS-KSLFAVTVEGKVY 3014
T +VFV+GLN + LG VP E L + ++ GS + T +G VY
Sbjct: 38 TDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVY 97
Query: 3015 ACGEATNGRLGLGISS-GTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE 3073
A G +LG G ++ G P+ L VV+ V G H+ AL DG+VF+WG
Sbjct: 98 AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE---VACGSHHSMALAADGEVFAWGY 154
Query: 3074 GDDGKLGHFSRMNCDKPRLI-EALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
+ G++G S N PR + L KR+ IACG + S A+ +GE+Y WG G+LG
Sbjct: 155 NNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG 214
Query: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG 3192
G+N QL P V L V Q+ CG A TLALTDEGL+++WG +G+LG G
Sbjct: 215 LGNNGNQLTPVRVAALHSVCVNQIVCGY--AHTLALTDEGLLYAWGANTYGQLGTGNKNN 272
Query: 3193 CNIPQNI----ERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
P +I ER+ C A S A T+ G V+ WG+
Sbjct: 273 LLSPAHIMVEKERVVEIAACH---SAHTSAAKTQGGHVYMWGQ 312
Score = 141 bits (356), Expect = 1e-32
Identities = 87/266 (32%), Positives = 142/266 (53%), Gaps = 13/266 (4%)
Query: 478 NSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEE 537
N TL P+ ++GL + I K ++ G H L G VY+WG +LG+G T
Sbjct: 59 NQSTLVPKKLEGLCGKKI-KSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIA 117
Query: 538 PKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLV 597
P + K VV +ACGS +S A+ A+GE++ WG N G++G GS+ ++ P V
Sbjct: 118 PVQVCT---NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKV 174
Query: 598 AGLKGLK-VIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQD 656
+K V+ +ACG ++AV +NG+V+ WG G+LG G + TP + L
Sbjct: 175 TNCLHIKRVVGIACGQ--TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHS 232
Query: 657 LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAA 716
+ V ++ CG ++ALT +G +Y+WG +LG G + ++ P + ++ ++V+++AA
Sbjct: 233 VCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIM-VEKERVVEIAA 291
Query: 717 -GSTH-CLALTEDSEVHSWGSNDQCQ 740
S H A T+ V+ WG QC+
Sbjct: 292 CHSAHTSAAKTQGGHVYMWG---QCR 314
Score = 139 bits (349), Expect = 9e-32
Identities = 90/300 (30%), Positives = 150/300 (50%), Gaps = 9/300 (3%)
Query: 3980 EALATLRPVQLIG--GEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHV 4037
+ +A++R + G + L+ VT + +++ G LG G +S P LE +
Sbjct: 16 QEIASIRKACVFGTSASEALY-VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGK 74
Query: 4038 FIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRP-RVIESLRGIEVVDV 4096
IK ++ SG H L + +G VY+WG +LG+G + P +V +L +VV+V
Sbjct: 75 KIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEV 133
Query: 4097 AAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRVVDIACGSGDA 4155
A G HS + A G+++ WG G++G + +Q P K+ L RVV IACG
Sbjct: 134 ACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ--T 191
Query: 4156 QTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKS 4215
++ + D+ V+ WG G+LG G + P+++ +L + V ++ CG ++ALT
Sbjct: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Query: 4216 GAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCC-TEDGEVYTWG 4274
G +Y WG Y +LG G+ +++ P + + + V A S H T+ G VY WG
Sbjct: 252 GLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 136 bits (343), Expect = 4e-31
Identities = 89/286 (31%), Positives = 146/286 (51%), Gaps = 10/286 (3%)
Query: 3001 SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
S++L+ VT +V+ G + LG G + T+ +P+++ L +K ++ + G H
Sbjct: 32 SEALY-VTDNDEVFVFGLNYSNCLGTGDNQSTL-VPKKLEGLCGKKIKSLS-YGSGPHVL 88
Query: 3061 ALTVDGKVFSWGEGDDGKLGHFSRMNCDKP-RLIEALKTKRIRDIACGSSHSAALTSSGE 3119
T DG V++WG +LG+ + P ++ L K++ ++ACGS HS AL + GE
Sbjct: 89 LSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE 148
Query: 3120 LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLG-HRVIQVACGSRDAQTLALTDEGLVFSWG 3178
++ WG G++G G Q P+ V L RV+ +ACG ++A+ D G V+ WG
Sbjct: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ--TSSMAVLDNGEVYGWG 206
Query: 3179 DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
G+LG G + P + L+ V QI CG +LALT G+++ WG Y +LG
Sbjct: 207 YNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
Query: 3239 HGSDVHVRKPQVVEGLRGKKIVHVAV--GALHCLAVTDSGQVYAWG 3282
G+ ++ P + + +++V +A A A T G VY WG
Sbjct: 267 TGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 132 bits (332), Expect = 8e-30
Identities = 89/294 (30%), Positives = 141/294 (47%), Gaps = 6/294 (2%)
Query: 4029 TLLESIQHVFIKKVAV-NSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES 4087
TLL + I+K V + L ++ EV+ +G LG G+ P+ +E
Sbjct: 11 TLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG 70
Query: 4088 LRGIEVVDVAAG-GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRV 4145
L G ++ ++ G G H T G +Y WG Y +LG+ + + P ++ L +V
Sbjct: 71 LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQV 130
Query: 4146 VDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLG-VVKVEC 4204
V++ACGS ++ L D V++WG + G++G G + P K+ + + VV + C
Sbjct: 131 VEVACGSH--HSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188
Query: 4205 GSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCC 4264
G S+A+ +G VY WG +LG G++ + P +V L V I G H +
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248
Query: 4265 TEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWST 4318
T++G +Y WG N GQLG G N + P + + + V AC SAHT A T
Sbjct: 249 TDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
Score = 129 bits (323), Expect = 9e-29
Identities = 89/298 (29%), Positives = 144/298 (48%), Gaps = 9/298 (3%)
Query: 3032 TVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPR 3091
T+ P++I ++ K + A +T + +VF +G LG + P+
Sbjct: 11 TLLSPQEIASIR----KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66
Query: 3092 LIEALKTKRIRDIACGSS-HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV-LL 3149
+E L K+I+ ++ GS H T G +Y WG Y +LG+G + P V LL
Sbjct: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
Query: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVC 3208
+V++VACGS ++AL +G VF+WG + G++G G + P+ + L+ + V
Sbjct: 127 IKQVVEVACGSH--HSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVV 184
Query: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3268
I CG S+A+ +G V+ WG +LG G++ + P V L + + G H
Sbjct: 185 GIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAH 244
Query: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
LA+TD G +YAWG N +GQ G G P + + + + AC S+H+ A T
Sbjct: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
Score = 113 bits (283), Expect = 4e-24
Identities = 69/220 (31%), Positives = 105/220 (47%), Gaps = 3/220 (1%)
Query: 3952 GTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
G +Y WGHN QLG G + C L + V++ G A+ ADG+++A G
Sbjct: 94 GVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG 153
Query: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070
Y G++G G T + TP + + H+ + V + G +A+ GEVY WG +G+
Sbjct: 154 YNNCGQVGSGSTANQPTPRKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQ 212
Query: 4071 LGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSED 4130
LG GN P + +L + V + G AH+ +T G LY WG YG+LG + +
Sbjct: 213 LGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNN 272
Query: 4131 QLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWG 4170
L P + ++ RVV+IA + T V+ WG
Sbjct: 273 LLSPAHI-MVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 113 bits (282), Expect = 5e-24
Identities = 71/225 (31%), Positives = 114/225 (50%), Gaps = 9/225 (4%)
Query: 515 EVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS-TYSAAITAEGELY 573
EV+ +G LG GD PK + GK+ + ++ GS + T +G +Y
Sbjct: 42 EVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKK----IKSLSYGSGPHVLLSTEDGVVY 97
Query: 574 TWGRGNYGRLGHGSSEDEAIPMLV-AGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 632
WG Y +LG+G++ P+ V L +V++VACGS + LA +G+V++WG
Sbjct: 98 AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA--DGEVFAWGYN 155
Query: 633 DYGKLGRGGSDGCKTP-KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGH 691
+ G++G G + TP K+ L VV + CG S+A+ +G+VY WG N +LG
Sbjct: 156 NCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGL 215
Query: 692 GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN 736
G + P + L V + G H LALT++ +++WG+N
Sbjct: 216 GNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGAN 260
Score = 111 bits (278), Expect = 2e-23
Identities = 77/246 (31%), Positives = 118/246 (47%), Gaps = 7/246 (2%)
Query: 2937 KGNSGSLIRKKAAGLESAATIRTK---VFVWGLNDKDQLG-GLKGSKIKVPSFSETLSAL 2992
+G G I+ + G + T+ V+ WG N QLG G I L
Sbjct: 69 EGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIK 128
Query: 2993 NVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAV 3052
VV+VA GS A+ +G+V+A G G++G G S+ P PR++T ++ + V +
Sbjct: 129 QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSG-STANQPTPRKVTNCL-HIKRVVGI 186
Query: 3053 HSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSA 3112
G + A+ +G+V+ WG +G+LG + N P + AL + + I CG +H+
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTL 246
Query: 3113 ALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG 3172
ALT G LY WG YG+LG G+ L P + V RV+++A + A T G
Sbjct: 247 ALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV-EKERVVEIAACHSAHTSAAKTQGG 305
Query: 3173 LVFSWG 3178
V+ WG
Sbjct: 306 HVYMWG 311
Score = 94.7 bits (234), Expect = 2e-18
Identities = 57/181 (31%), Positives = 96/181 (53%), Gaps = 12/181 (6%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIG---GEQTLFAVT 4001
+++ G ++ WG+N+ GQ+G G+ PTP + L +++G G+ + AV
Sbjct: 140 SMALAADGEVFAWGYNNCGQVG--SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197
Query: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
+G++Y GY G+LG+G + TP + ++ V + ++ G H LAL+ EG +Y
Sbjct: 198 DNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIV--CGYAHTLALTDEGLLY 255
Query: 4062 SWGEAEDGKLGHGNRSPCDRPR--VIESLRGIEVVDVAAGGAH-SACVTAAGDLYTWGKG 4118
+WG G+LG GN++ P ++E R +E+ A AH SA T G +Y WG+
Sbjct: 256 AWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEI--AACHSAHTSAAKTQGGHVYMWGQC 313
Query: 4119 R 4119
R
Sbjct: 314 R 314
Score = 87.8 bits (216), Expect = 2e-16
Identities = 58/168 (34%), Positives = 85/168 (50%), Gaps = 3/168 (1%)
Query: 611 GSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSI 670
G+ ++ L VT+N +V+ +G LG G + PK +E L + + GS +
Sbjct: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
Query: 671 AL-TKDGQVYSWGKGDNQRLGHGTEEHVRYP-KLLEGLQGKKVIDVAAGSTHCLALTEDS 728
L T+DG VY+WG +LG+GT P ++ L K+V++VA GS H +AL D
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
Query: 729 EVHSWGSNDQCQHFDTLRVTKPEPAALPG-LDTKHIVGIACGPAQSFA 775
EV +WG N+ Q +P P + L K +VGIACG S A
Sbjct: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA 195
Score = 82.8 bits (203), Expect = 8e-15
Identities = 64/223 (28%), Positives = 98/223 (43%), Gaps = 24/223 (10%)
Query: 425 VIGWGLIGWKYYANV-----IGPIQ-CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN 478
V WG G+ N I P+Q C L V ++AC + L+ +G V+ YN
Sbjct: 96 VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155
Query: 479 ------SDTLAPQ-----LVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRL 527
S + A Q + L + +V IA +A+ GEVY WG G+L
Sbjct: 156 NCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSS--MAVLDNGEVYGWGYNGNGQL 213
Query: 528 GHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGS 587
G G+ P ++A V I CG ++ A+T EG LY WG YG+LG G+
Sbjct: 214 GLGNNGNQLTPVRVAALH----SVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGN 269
Query: 588 SEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWG 630
+ P + ++ +V+++A + A T+ G V+ WG
Sbjct: 270 KNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 41.2 bits (95), Expect = 0.025
Identities = 31/112 (27%), Positives = 46/112 (41%), Gaps = 16/112 (14%)
Query: 424 EVIGWGL-----IGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN 478
EV GWG +G N + P++ L ++ V QI C L L+ G +Y N
Sbjct: 201 EVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGAN 260
Query: 479 ----------SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWG 520
++ L+P + + +V+IAA H A G VY WG
Sbjct: 261 TYGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 36.2 bits (82), Expect = 0.81
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 3248 PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 3307
PQ + +R K A L VTD+ +V+ +G N G G P ++GL
Sbjct: 15 PQEIASIR--KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
Query: 3308 GQKITRVACGSSHSVAWTTVD 3328
G+KI ++ GS V +T D
Sbjct: 73 GKKIKSLSYGSGPHVLLSTED 93
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 144 bits (363), Expect = 2e-33
Identities = 91/262 (34%), Positives = 141/262 (53%), Gaps = 18/262 (6%)
Query: 3048 KKVAVHS---GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDI 3104
K + +HS G H L+ DGK F + D+ + H R L+ K+I I
Sbjct: 95 KNMKIHSVDQGAEHMLILSSDGKPFEY---DNYSMKHL--------RFESILQEKKIIQI 143
Query: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDA 3163
CG HS AL+ GEL+ WG +G+LG G + P++V+ L G + Q++ G +A
Sbjct: 144 TCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG--EA 201
Query: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223
++AL+ G ++SWG + G+LG G +E + P IE L+ Q V + CG S LT+
Sbjct: 202 HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQD 261
Query: 3224 GVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA-VTDSGQVYAWG 3282
G+++T+G G + +LGH S + +P +V L G ++ +A G H LA V+D G+V+++G
Sbjct: 262 GLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFG 321
Query: 3283 DNDHGQQGNGTTTVNRKPTLVQ 3304
GQ GNG T P V+
Sbjct: 322 SGKDGQLGNGGTRDQLMPLPVK 343
Score = 142 bits (358), Expect = 8e-33
Identities = 76/213 (35%), Positives = 127/213 (59%), Gaps = 5/213 (2%)
Query: 2985 FSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSS 3044
F L ++Q+ G A++ G+++A G+ +G+LG+G + P+ + L+
Sbjct: 131 FESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAG 190
Query: 3045 YVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDI 3104
+ +++ +G H+ AL++ G ++SWG+ + G+LG + D P LIE L +++ +
Sbjct: 191 VPLAQIS--AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFV 248
Query: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQ 3164
ACG SHSA LT G L+T+G G++G+LGH +L+P +V L+G+RV Q+ACG
Sbjct: 249 ACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGR--WH 306
Query: 3165 TLA-LTDEGLVFSWGDGDFGKLGRGGSEGCNIP 3196
TLA ++D G VFS+G G G+LG GG+ +P
Sbjct: 307 TLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339
Score = 138 bits (348), Expect = 1e-31
Identities = 79/206 (38%), Positives = 125/206 (60%), Gaps = 6/206 (2%)
Query: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGT-ESVSTPTLLESIQHVFIKKVAVNS 4046
+Q+ G+ A++ G+L+A G G+LG+G S +TP ++E + V + +++ +
Sbjct: 141 IQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS--A 198
Query: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106
G H +ALS G +YSWG+ E G+LG G+ D P +IE L +V VA GG+HSA +
Sbjct: 199 GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL 258
Query: 4107 TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD-DT 4165
T G L+T+G G++G+LGH+ ++++L+P LV L G+RV IACG TL D
Sbjct: 259 TQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW--HTLAYVSDLGK 316
Query: 4166 VWSWGDGDYGKLGRGGSDGCKVPMKI 4191
V+S+G G G+LG GG+ +P+ +
Sbjct: 317 VFSFGSGKDGQLGNGGTRDQLMPLPV 342
Score = 130 bits (328), Expect = 2e-29
Identities = 75/238 (31%), Positives = 123/238 (51%), Gaps = 14/238 (5%)
Query: 3090 PRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLL 3149
P+ I+ K +I + G+ H L+S G+ + + DN + + +L
Sbjct: 88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEY-----------DNYSMKHLRFESILQ 136
Query: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGS-EGCNIPQNIERLNGQGVC 3208
++IQ+ CG D +LAL+ G +F+WG G+LG G PQ +E L G +
Sbjct: 137 EKKIIQITCG--DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3268
QI G S+AL+ SG +++WGK + +LG G P ++EGL +K+ VA G H
Sbjct: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSH 254
Query: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
+T G ++ +G HGQ G+ +T +P LV L G ++T++ACG H++A+ +
Sbjct: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
Score = 125 bits (313), Expect = 1e-27
Identities = 85/311 (27%), Positives = 151/311 (48%), Gaps = 28/311 (9%)
Query: 4019 IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSP 4078
+ G+ TP ++ +++ I +V+ G +H L LSS+G+ + + L
Sbjct: 79 LAGSGGARTPKCIKLGKNMKIH--SVDQGAEHMLILSSDGKPFEYDNYSMKHL------- 129
Query: 4079 CDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS-EDQLKPKLV 4137
R L+ +++ + G HS ++ G+L+ WG+ +G+LG P++V
Sbjct: 130 ----RFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIV 185
Query: 4138 EALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGL 4197
E L G + I+ +G+A ++ L+ ++SWG + G+LG G ++ P I+ L
Sbjct: 186 EHLAGVPLAQIS--AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQ 243
Query: 4198 GVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATG 4257
V V CG S LT+ G ++T+G G + +LGH S + RP V L G +V IA G
Sbjct: 244 KVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACG 303
Query: 4258 SLHCVCCTED-GEVYTWGDNDEGQLGDGTT-----------NAIQRPRLVAALQGKKVNR 4305
H + D G+V+++G +GQLG+G T ++ + +L + K++
Sbjct: 304 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIM 363
Query: 4306 VACGSAHTLAW 4316
+A G+ L W
Sbjct: 364 IAGGNQSILLW 374
Score = 124 bits (311), Expect = 2e-27
Identities = 73/202 (36%), Positives = 115/202 (56%), Gaps = 20/202 (9%)
Query: 453 VTQIACAEKRFLILSRNGRVYTQAYN-----------SDTLAPQLVQGLASRNIVKIAAH 501
+ QI C + L LS+ G ++ N T PQ+V+ LA + +I+A
Sbjct: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG 199
Query: 502 SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGST 561
H +AL+ +G +YSWG + G+LG G T ++P +I ++ V +ACG +
Sbjct: 200 EA--HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQK----VEFVACGGS 253
Query: 562 YSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLA-V 620
+SA +T +G L+T+G G +G+LGH S+++E P LVA L G +V +ACG TLA V
Sbjct: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW--HTLAYV 311
Query: 621 TENGQVWSWGDGDYGKLGRGGS 642
++ G+V+S+G G G+LG GG+
Sbjct: 312 SDLGKVFSFGSGKDGQLGNGGT 333
Score = 120 bits (301), Expect = 3e-26
Identities = 81/292 (27%), Positives = 145/292 (49%), Gaps = 25/292 (8%)
Query: 455 QIACAEKRFLILSRNG---RVYTQ-AYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLAL 510
Q+ C+ R +L R G +V+ A + P+ ++ +N+ + H L L
Sbjct: 55 QLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIK--LGKNMKIHSVDQGAEHMLIL 112
Query: 511 AATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEG 570
++ G+ + + D ++ + S K+ ++ I CG +S A++ G
Sbjct: 113 SSDGKPFEY-----------DNYSMKHLRFESILQEKK----IIQITCGDYHSLALSKGG 157
Query: 571 ELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629
EL+ WG+ +G+LG G P +V L G+ + ++ +G+A ++A++ +G ++SW
Sbjct: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS--AGEAHSMALSMSGNIYSW 215
Query: 630 GDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 689
G + G+LG G ++ P LIE L + V V CG S LT+DG ++++G G + +L
Sbjct: 216 GKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQL 275
Query: 690 GHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSWGSNDQCQ 740
GH + ++ P L+ L G +V +A G H LA D +V S+GS Q
Sbjct: 276 GHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQ 327
Score = 114 bits (286), Expect = 2e-24
Identities = 74/246 (30%), Positives = 130/246 (52%), Gaps = 13/246 (5%)
Query: 450 NLGVTQIACAEKRFLILSRNGRVYT-QAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYL 508
N+ + + + LILS +G+ + Y+ L + + L + I++I +H L
Sbjct: 96 NMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESI--LQEKKIIQITCGD--YHSL 151
Query: 509 ALAATGEVYSWGCGDGGRLGHGDTVP-LEEPKVISAFSGKQAGKHVVHIACGSTYSAAIT 567
AL+ GE+++WG G+LG G P P+++ AG + I+ G +S A++
Sbjct: 152 ALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHL----AGVPLAQISAGEAHSMALS 207
Query: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVW 627
G +Y+WG+ G+LG G +E + P L+ GL KV VACG + L T++G ++
Sbjct: 208 MSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL--TQDGLLF 265
Query: 628 SWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKD-GQVYSWGKGDN 686
++G G +G+LG + P L+ +L V ++ CG ++A D G+V+S+G G +
Sbjct: 266 TFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKD 325
Query: 687 QRLGHG 692
+LG+G
Sbjct: 326 GQLGNG 331
Score = 108 bits (270), Expect = 1e-22
Identities = 64/195 (32%), Positives = 105/195 (53%), Gaps = 4/195 (2%)
Query: 3942 DDWTLSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAV 4000
D +L+ G ++ WG N GQLG G + P E LA + Q+ GE A+
Sbjct: 147 DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206
Query: 4001 TADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEV 4060
+ G +Y+ G G+LG+G TES P+L+E + + ++ VA GG H L+ +G +
Sbjct: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVA--CGGSHSALLTQDGLL 264
Query: 4061 YSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHS-ACVTAAGDLYTWGKGR 4119
+++G + G+LGH + RP ++ L G V +A G H+ A V+ G ++++G G+
Sbjct: 265 FTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGK 324
Query: 4120 YGRLGHSDSEDQLKP 4134
G+LG+ + DQL P
Sbjct: 325 DGQLGNGGTRDQLMP 339
Score = 108 bits (270), Expect = 1e-22
Identities = 69/190 (36%), Positives = 104/190 (54%), Gaps = 5/190 (2%)
Query: 2960 KVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGE 3018
++F WG N QLG G K P E L+ + + Q++ G A+++ G +Y+ G+
Sbjct: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
Query: 3019 ATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGK 3078
G+LGLG + + P I L + V+ VA GG H+ LT DG +F++G G G+
Sbjct: 218 NECGQLGLG-HTESKDDPSLIEGLDNQKVEFVA--CGGSHSALLTQDGLLFTFGAGKHGQ 274
Query: 3079 LGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSS-GELYTWGLGEYGRLGHGDNT 3137
LGH S N +P L+ L R+ IACG H+ A S G+++++G G+ G+LG+G
Sbjct: 275 LGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTR 334
Query: 3138 TQLKPKMVKV 3147
QL P VKV
Sbjct: 335 DQLMPLPVKV 344
Score = 99.4 bits (246), Expect = 8e-20
Identities = 57/180 (31%), Positives = 95/180 (52%), Gaps = 3/180 (1%)
Query: 600 LKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIEKLQDLD 658
L+ K+I + CG D +LA+++ G++++WG +G+LG G TP+++E L +
Sbjct: 135 LQEKKIIQITCG--DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVP 192
Query: 659 VVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGS 718
+ ++ G S+AL+ G +YSWGK + +LG G E P L+EGL +KV VA G
Sbjct: 193 LAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGG 252
Query: 719 THCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
+H LT+D + ++G+ Q + P + L + IACG + A+ S
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
Score = 78.6 bits (192), Expect = 1e-13
Identities = 71/259 (27%), Positives = 117/259 (45%), Gaps = 16/259 (6%)
Query: 4535 FLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSE 4594
F GVL G+++ + +L ++K+L ++ DL E+ D L + D+E +
Sbjct: 769 FFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNF 828
Query: 4595 EFEAMSLPFTVPSASGQDIQLSSKHTHITLD--NRAEYVRLAINYRLHEFDEQVAAV--- 4649
E E + F V D L + IT++ N+ +YV INY F++ V AV
Sbjct: 829 E-EVFYIHFNV-HWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYI---FNDSVKAVYEE 883
Query: 4650 -REGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEPSASLIQWFWEV 4707
R G ++ ++ LF EL+ ++ G+ D + A Y+ G S I FW+
Sbjct: 884 FRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKA 943
Query: 4708 MESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLK 4767
+ E+ FL F+ G RL + D + +N D + TCF +L
Sbjct: 944 FHKLTLEEKKKFLVFLTGTDRLQ--MKDLNNMKITFCCPESWNERDPI--RALTCFSVLF 999
Query: 4768 LPRYSCKQVLEEKLKYAIH 4786
LP+YS + +EE L+ AI+
Sbjct: 1000 LPKYSTMETVEEALQEAIN 1018
Score = 70.9 bits (172), Expect = 3e-11
Identities = 51/192 (26%), Positives = 91/192 (47%), Gaps = 25/192 (13%)
Query: 424 EVIGWGL-------IGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQA 476
E+ WG +G K+ + I E LA + + QI+ E + LS +G +Y+
Sbjct: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQI-VEHLAGVPLAQISAGEAHSMALSMSGNIYSWG 216
Query: 477 YNS----------DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGR 526
N P L++GL ++ + +A G H L G ++++G G G+
Sbjct: 217 KNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC--GGSHSALLTQDGLLFTFGAGKHGQ 274
Query: 527 LGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAE-GELYTWGRGNYGRLGH 585
LGH T P +++ G V IACG ++ A ++ G+++++G G G+LG+
Sbjct: 275 LGHNSTQNELRPCLVAEL----VGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGN 330
Query: 586 GSSEDEAIPMLV 597
G + D+ +P+ V
Sbjct: 331 GGTRDQLMPLPV 342
Score = 33.1 bits (74), Expect = 6.9
Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 12/91 (13%)
Query: 4227 HRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTT 4286
H+L GS R P+ ++ + K+ ++ G+ H + + DG+ + + DN
Sbjct: 76 HQLLAGSGG-ARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEY-DN---------- 123
Query: 4287 NAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4317
+++ R + LQ KK+ ++ CG H+LA S
Sbjct: 124 YSMKHLRFESILQEKKIIQITCGDYHSLALS 154
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 140 bits (352), Expect = 4e-32
Identities = 102/357 (28%), Positives = 172/357 (48%), Gaps = 29/357 (8%)
Query: 4441 KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPL 4500
K++F ++ SF P L R+W + F GE D GG E + E+ N + L
Sbjct: 514 KTLFEDSFQQIMSFSPQDLR--RRLWVI-FPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
Query: 4501 LIVTPNGRDESGANRDCYLLSPAARA-PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVW 4559
+ +G + C ++PA+ P H FRF+G + +A+ G + + P +
Sbjct: 571 F-------EYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY 623
Query: 4560 KQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSA-----SGQDIQ 4614
K++ + + DL +D +F L+++++N + E + F+V D++
Sbjct: 624 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLE---MYFSVDKEILGEIKSHDLK 680
Query: 4615 LSSKHTHITLDNRAEYVRLAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETM 4673
+ + +T +N+ EY+R+ +RL +EQ A EG ++P L F ELE +
Sbjct: 681 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL 740
Query: 4674 VCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLP-RT 4732
+CG +I L+ + A Y+ ++ I WFW+ ++ N +R L+FV G RLP
Sbjct: 741 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG 800
Query: 4733 IADFRG----RDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
AD G + F I+ + K N +LP S+TCF L LP Y + L+EKL +AI
Sbjct: 801 FADLMGSNGPQKFCIEKVGKEN----WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 138 bits (348), Expect = 1e-31
Identities = 110/363 (30%), Positives = 166/363 (45%), Gaps = 31/363 (8%)
Query: 4026 STPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW-----GEAEDGKLGHGNRSPCD 4080
STP L+ I+ + V +G H ++ E E+Y+W G G+LGHG+++
Sbjct: 357 STPQKLDVIKSGCSAR-QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 415
Query: 4081 RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD--SEDQLKPKLVE 4138
+P+ +E L+G + V+ G + CVT G LY +G YG +G + L+P +
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 475
Query: 4139 ALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLG 4198
+ V ++CG D + LT + V+SWG G+YG+LG + P K+D L
Sbjct: 476 FFLSNPVEQVSCG--DNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI 533
Query: 4199 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLG----------HGSDDHVRRPRQ---VQG 4245
+V V+CG + LT+SG V G ++++LG H + V +
Sbjct: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593
Query: 4246 LQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAA-LQGKKVN 4304
L K+ IA G H E G + T+G N GQLG G L+ L GK+V
Sbjct: 594 LSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVI 653
Query: 4305 RVACGSAHTLAWSTSKPASA------GKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSE 4358
RV+CG T+A + A G+L A P E H +I R LHH+ +
Sbjct: 654 RVSCGDEFTIAATDDNHIFAWGNGGNGRL-AMTPTERPHGSDICTSWPRPIFGSLHHVPD 712
Query: 4359 LFC 4361
L C
Sbjct: 713 LSC 715
Score = 115 bits (288), Expect = 1e-24
Identities = 90/332 (27%), Positives = 148/332 (44%), Gaps = 40/332 (12%)
Query: 464 LILSRNGRVYTQAYNSDTLAPQ----LVQGLASRNIVKIAAHSDGHHYLALAATGEVYSW 519
++ SR VY T PQ + G ++R + + H+ + E+Y+W
Sbjct: 341 VVTSRTSEVYVWGGGKST--PQKLDVIKSGCSARQVC-----AGNTHFAVVTVEKELYTW 393
Query: 520 GCGDGG-----RLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYT 574
GG +LGHGD +PK + K GK + ++CG ++ +T EG+LY
Sbjct: 394 VNMQGGTKLHGQLGHGDKASYRQPKHVE----KLQGKAIRQVSCGDDFTVCVTDEGQLYA 449
Query: 575 WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 632
+G YG +G + PM + V V+CG D + +T N +V+SWG G
Sbjct: 450 FGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCG--DNHVVVLTRNKEVYSWGCG 507
Query: 633 DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-- 690
+YG+LG + TP+ ++ + L +V V+CG + LT+ G+V + G + +LG
Sbjct: 508 EYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLN 567
Query: 691 ---HGTEEHVRYPK--------LLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 739
G H Y + L + L K+ +A G TH A+ E + ++G N +C
Sbjct: 568 QCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN-KC 626
Query: 740 QHFDTLRVTKPEPAALPG--LDTKHIVGIACG 769
K L G L K ++ ++CG
Sbjct: 627 GQLGVGNYKKRLGINLLGGPLGGKQVIRVSCG 658
Score = 112 bits (279), Expect = 1e-23
Identities = 83/278 (29%), Positives = 132/278 (47%), Gaps = 35/278 (12%)
Query: 3067 KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAALTSSGELYTW-- 3123
+V+ WG G P+ ++ +K+ R + G++H A +T ELYTW
Sbjct: 348 EVYVWGGGKS------------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVN 395
Query: 3124 ---GLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180
G +G+LGHGD + +PK V+ L G + QV+CG D T+ +TDEG ++++G
Sbjct: 396 MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG--DDFTVCVTDEGQLYAFGSD 453
Query: 3181 DFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
+G +G G + P + V Q+ CG + LT++ V++WG G+Y RLG
Sbjct: 454 YYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLG 513
Query: 3239 HGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNG---TTT 3295
S+ PQ V+ + IV V G +T SG+V A G N+ + G +
Sbjct: 514 LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGI 573
Query: 3296 VNRKP----------TLVQGLEGQKITRVACGSSHSVA 3323
+N + TL + L KI +A G +H+ A
Sbjct: 574 INHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAA 611
Score = 105 bits (261), Expect = 1e-21
Identities = 93/345 (26%), Positives = 153/345 (44%), Gaps = 37/345 (10%)
Query: 2940 SGSLIRKKAAGLESAA--TIRTKVFVW-----GLNDKDQLGGLKGSKIKVPSFSETLSAL 2992
SG R+ AG A T+ +++ W G QLG + + P E L
Sbjct: 367 SGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGK 426
Query: 2993 NVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPI-PRQITALSSYVVKKVA 3051
+ QV+ G VT EG++YA G G +G+ +G + P Q+ S V++V+
Sbjct: 427 AIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVS 486
Query: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHS 3111
G H LT + +V+SWG G+ G+LG S + P+ ++ K I + CG +
Sbjct: 487 C--GDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGT 544
Query: 3112 AALTSSGELYTWGLGEYGRLG-------------HGDNTTQLKPKMVKVLLGHRVIQVAC 3158
LT SG++ GL E+ +LG + + + K L +++ +A
Sbjct: 545 FLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAP 604
Query: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSE---GCNIPQNIERLNGQGVCQIECGAQ 3215
G T A+ + G + ++G G+LG G + G N+ L G+ V ++ CG +
Sbjct: 605 GK--THTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGG--PLGGKQVIRVSCGDE 660
Query: 3216 FSLALTKSGVVWTWGKGDYFRLG-------HGSDVHVRKPQVVEG 3253
F++A T ++ WG G RL HGSD+ P+ + G
Sbjct: 661 FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG 705
Score = 101 bits (251), Expect = 2e-20
Identities = 91/364 (25%), Positives = 156/364 (42%), Gaps = 50/364 (13%)
Query: 2953 SAATIRT-KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEG 3011
+ T RT +V+VWG G K S + QV G+ VTVE
Sbjct: 340 AVVTSRTSEVYVWG-----------GGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEK 388
Query: 3012 KVYAC-----GEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDG 3066
++Y G +G+LG G + P+ + L +++V+ G +T +G
Sbjct: 389 ELYTWVNMQGGTKLHGQLGHG-DKASYRQPKHVEKLQGKAIRQVSC--GDDFTVCVTDEG 445
Query: 3067 KVFSWGEGDDGKLGHFSRMNCDK---PRLIEALK-----TKRIRDIACGSSHSAALTSSG 3118
+++++G ++ M DK P ++E ++ + + ++CG +H LT +
Sbjct: 446 QLYAFGSD------YYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK 499
Query: 3119 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3178
E+Y+WG GEYGRLG P+ V V ++ V CG T LT G V + G
Sbjct: 500 EVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDG--TFLLTQSGKVLACG 557
Query: 3179 DGDFGKLGRGGSEGCNIPQNI-------------ERLNGQGVCQIECGAQFSLALTKSGV 3225
+F KLG I ++L+ + I G + A+ + G
Sbjct: 558 LNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGR 617
Query: 3226 VWTWGKGDYFRLGHGSDVHVRKPQVVEG-LRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3284
+ T+G +LG G+ ++ G L GK+++ V+ G +A TD ++AWG+
Sbjct: 618 LLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNG 677
Query: 3285 DHGQ 3288
+G+
Sbjct: 678 GNGR 681
Score = 93.2 bits (230), Expect = 6e-18
Identities = 83/321 (25%), Positives = 135/321 (42%), Gaps = 34/321 (10%)
Query: 3954 IYGW-----GHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYA 4008
+Y W G GQLG + A + P E L Q+ G+ VT +G+LYA
Sbjct: 390 LYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYA 449
Query: 4009 TGYGAGGRLGIGGTESVSTPTLLESIQHVFIKK---VAVNSGGKHCLALSSEGEVYSWGE 4065
G G +G+ + V+ P +LE +Q F V+ G H + L+ EVYSWG
Sbjct: 450 FGSDYYGCMGV---DKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGC 506
Query: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG- 4124
E G+LG + P+ ++ + + +V V G + +T +G + G + +LG
Sbjct: 507 GEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGL 566
Query: 4125 ------------HSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDG 4172
+ + L + L +++ IA G T + + + ++G
Sbjct: 567 NQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIA--PGKTHTAAIDERGRLLTFGCN 624
Query: 4173 DYGKLGRGG-SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG- 4230
G+LG G + + L G V++V CG +F++A T ++ WG G RL
Sbjct: 625 KCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
Query: 4231 ------HGSDDHVRRPRQVQG 4245
HGSD PR + G
Sbjct: 685 TPTERPHGSDICTSWPRPIFG 705
Score = 87.0 bits (214), Expect = 4e-16
Identities = 82/333 (24%), Positives = 138/333 (41%), Gaps = 46/333 (13%)
Query: 429 GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-------- 480
G +G A+ P E L + Q++C + + ++ G++Y A+ SD
Sbjct: 404 GQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLY--AFGSDYYGCMGVD 461
Query: 481 ------TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVP 534
L P + S + +++ + H + L EVYSWGCG+ GRLG
Sbjct: 462 KVAGPEVLEPMQLNFFLSNPVEQVSCGDN--HVVVLTRNKEVYSWGCGEYGRLGLDSEED 519
Query: 535 LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLG-----HGSSE 589
P+ + +V + CG + +T G++ G + +LG G
Sbjct: 520 YYTPQKVDV----PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIIN 575
Query: 590 DEA---IPM-----LVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG 641
EA +P L L K+ +A G T A+ E G++ ++G G+LG G
Sbjct: 576 HEAYHEVPYTTSFTLAKQLSFYKIRTIA--PGKTHTAAIDERGRLLTFGCNKCGQLGVGN 633
Query: 642 SDGCKTPKLIE-KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-------HGT 693
L+ L V++V CG +F+IA T D +++WG G N RL HG+
Sbjct: 634 YKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGS 693
Query: 694 EEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTE 726
+ +P+ + G V D++ H + + E
Sbjct: 694 DICTSWPRPIFG-SLHHVPDLSCRGWHTILIVE 725
Score = 84.7 bits (208), Expect = 2e-15
Identities = 73/266 (27%), Positives = 128/266 (48%), Gaps = 26/266 (9%)
Query: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATL-RPVQLIG-GEQTLFA 3999
DD+T+ G +Y +G ++ G +G + A +V P + L PV+ + G+ +
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
Query: 4000 VTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGE 4059
+T + ++Y+ G G GRLG+ E TP ++ + + I VAV G L+ G+
Sbjct: 495 LTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALII--VAVQCGCDGTFLLTQSGK 552
Query: 4060 VYSWGEAEDGKLG--------HGNRSPCDRP-----RVIESLRGIEVVDVAAGGAHSACV 4106
V + G E KLG + + + P + + L ++ +A G H+A +
Sbjct: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAI 612
Query: 4107 TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-LQGHRVVDIACGSGDAQTLCLTDDDT 4165
G L T+G + G+LG + + +L L+ L G +V+ ++C GD T+ TDD+
Sbjct: 613 DERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC--GDEFTIAATDDNH 670
Query: 4166 VWSWGDGDYGKLGR------GGSDGC 4185
+++WG+G G+L GSD C
Sbjct: 671 IFAWGNGGNGRLAMTPTERPHGSDIC 696
Score = 46.6 bits (109), Expect = 6e-04
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 18/118 (15%)
Query: 3214 AQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLR-GKKIVHVAVGALHCLAV 3272
A ++ +++ V+ WG G PQ ++ ++ G V G H V
Sbjct: 337 APIAVVTSRTSEVYVWGGGK------------STPQKLDVIKSGCSARQVCAGNTHFAVV 384
Query: 3273 TDSGQVYAW-----GDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
T ++Y W G HGQ G+G R+P V+ L+G+ I +V+CG +V T
Sbjct: 385 TVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVT 442
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 134 bits (338), Expect = 2e-30
Identities = 107/341 (31%), Positives = 167/341 (48%), Gaps = 33/341 (9%)
Query: 4462 PHRVWK---VKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCY 4518
P +WK +KF GE D GG E + + E+ N P + RD D Y
Sbjct: 415 PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLN---PYYGLFQYSRD------DIY 465
Query: 4519 LLS---PAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEV 4575
L +A P H S F F+G ++G+A+ G + P +KQL G S+T+ D+ V
Sbjct: 466 TLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELV 525
Query: 4576 DKDFIPGLMYIRDNEATSEEFEAMSLPFTVP-SASGQDIQL----SSKHTHITLDNRAEY 4630
D D L++I +N+ T + F V +A G+ IQ + K + +N+ EY
Sbjct: 526 DPDLHNSLVWILENDITG----VLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEY 581
Query: 4631 VRLAINYR-LHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVA 4689
VRL +N+R L + Q A+++G V+P LL F ELE ++CG I ++ K
Sbjct: 582 VRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNT 641
Query: 4690 TYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLP----RTIADFRG-RDFVIQ 4744
K P +++++WFW+ +E F R+ L+FV G +R+P + + G R F I
Sbjct: 642 RLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIH 701
Query: 4745 VLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
+D + LP+++TCF + +P Y + L EKL AI
Sbjct: 702 QIDACT---NNLPKAHTCFNRIDIPPYESYEKLYEKLLTAI 739
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 134 bits (337), Expect = 2e-30
Identities = 100/328 (30%), Positives = 157/328 (47%), Gaps = 22/328 (6%)
Query: 4468 VKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA- 4526
V F GE D GG E + E+ N + L + +G N C ++PA+
Sbjct: 598 VIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF-------EYAGKNNYCLQINPASTIN 650
Query: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
P H S F F+G + +A+ G + + P +K++ LTI DL +D +F L++I
Sbjct: 651 PDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWI 710
Query: 4587 RDN---EATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHE-F 4642
RDN E E + ++ + + + D++L + +T +N+ EY+ L +R
Sbjct: 711 RDNNIEECGLEMYFSVDMEI-LGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGV 769
Query: 4643 DEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQ 4702
EQ A +G VVP+ L F ELE M+CG ++ L + Y+ ++ I
Sbjct: 770 QEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQII 829
Query: 4703 WFWEVMESFSNTERSLFLRFVWGRTRLP-RTIADFRG----RDFVIQVLDKYNPPDHFLP 4757
WFW+ ++ N R L+FV G RLP A+ G + F I+ + K D +LP
Sbjct: 830 WFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGK----DTWLP 885
Query: 4758 ESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
S+TCF L LP Y + L+EKL +AI
Sbjct: 886 RSHTCFNRLDLPPYKSYEQLKEKLLFAI 913
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 134 bits (337), Expect = 2e-30
Identities = 122/405 (30%), Positives = 178/405 (43%), Gaps = 33/405 (8%)
Query: 3937 MNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLI-GGEQ 3995
M R P + +A + ++ WG N GQLG V +P R V+ I GG
Sbjct: 1 MEREPSA-SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGG 59
Query: 3996 TLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALS 4055
VT G L+ G G+LG+G TE + T +S+ I++VA G + L+
Sbjct: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVAC--GWDFTIMLT 117
Query: 4056 SEGEVYSWGEAEDGKLG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113
G+V S G G+LG HG R C P+ IE L +VV +AAG H+ TA+G ++
Sbjct: 118 ENGQVLSCGSNSFGQLGVPHGPRR-CVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVF 175
Query: 4114 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACG------SGDAQTLCLTDDDTVW 4167
WG G G Q P A + RV + +G + LTD V+
Sbjct: 176 QWGTG-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVY 234
Query: 4168 SWGDGDYGKLGRGGSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGD 4225
WG +G+L + VP KI++ V + G VA T++G ++TWG+ D
Sbjct: 235 VWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRAD 293
Query: 4226 YHRLGHGSDDHV--RRPRQVQGLQGKKVIAIATGSLHCV-------CCTED------GEV 4270
Y +LG + + + +Q L + S HC+ C +E G
Sbjct: 294 YGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVC 353
Query: 4271 YTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4315
Y+WG N+ G GDGT + P+ V AL V CG+ H+LA
Sbjct: 354 YSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
Score = 132 bits (332), Expect = 8e-30
Identities = 130/448 (29%), Positives = 191/448 (42%), Gaps = 59/448 (13%)
Query: 2954 AATIRTKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
AA +F WG N QLG G K + ++ +V ++ GG VT G
Sbjct: 10 AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGD 69
Query: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
++ CG +G+LGLG + +P +L +++VA G LT +G+V S G
Sbjct: 70 LFVCGLNKDGQLGLGHTED-IPYFTPCKSLFGCPIQQVAC--GWDFTIMLTENGQVLSCG 126
Query: 3073 EGDDGKLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG- 3129
G+LG H R C P+ IE K K + IA G H+ A T+SG ++ WG G
Sbjct: 127 SNSFGQLGVPHGPR-RCVVPQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWGTGLASC 184
Query: 3130 --RLGHGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFG 3183
RL G T +P V L + + V GS + +LTD G V+ WG G
Sbjct: 185 GRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSD--HSASLTDAGEVYVWGSNKHG 242
Query: 3184 KLGRGGSEGCNIPQNIER--LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGS 3241
+L + +PQ IE + V I G +A T++G ++TWG+ DY +LG
Sbjct: 243 QLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG--- 298
Query: 3242 DVHVRKPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDSGQV 3278
RK + EG + +K V+ G+ H LA+ G
Sbjct: 299 ----RKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
Query: 3279 YAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPV 3338
Y+WG N+HG G+GT P VQ L V CG+ HS+A + V +P
Sbjct: 354 YSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPK 413
Query: 3339 LFQTARDPLGASYLGVPSDADSSAASNK 3366
+ + D + D +S A +K
Sbjct: 414 VTYLSPDAI--------EDTESQKAMDK 433
Score = 109 bits (272), Expect = 8e-23
Identities = 92/316 (29%), Positives = 145/316 (45%), Gaps = 43/316 (13%)
Query: 445 CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS-----------DTLAPQLVQGLASR 493
C+ L + Q+AC ++L+ NG+V + NS + PQ ++ L
Sbjct: 95 CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKE 153
Query: 494 NIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVPL----EEPKVISAFSG 546
+V IAA H +A A+G V+ WG G G RL G T+PL +EP ++
Sbjct: 154 KVVCIAAGL--RHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLEN 211
Query: 547 KQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVI 606
+A + + GS +SA++T GE+Y WG +G+L + ++ +P +
Sbjct: 212 SKA----MCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEK 266
Query: 607 DVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTPKLIEKLQD-------- 656
A SG +A TE G++++WG DYG+LGR +G K K L
Sbjct: 267 VTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMP 326
Query: 657 ------LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKK 710
+V CGS+ ++A+ G YSWG ++ G GTE +V PK ++ L
Sbjct: 327 SSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSS 385
Query: 711 VIDVAAGSTHCLALTE 726
+ V G+ H LAL +
Sbjct: 386 GLLVGCGAGHSLALCQ 401
Score = 106 bits (264), Expect = 6e-22
Identities = 80/240 (33%), Positives = 116/240 (48%), Gaps = 14/240 (5%)
Query: 509 ALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITA 568
A A +++WG G+LG G + P+ ++ F ++ V I G +SA +T
Sbjct: 10 AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRS---VRRITGGGGHSAVVTD 66
Query: 569 EGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWS 628
G+L+ G G+LG G +ED L G + VACG T+ +TENGQV S
Sbjct: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDF--TIMLTENGQVLS 124
Query: 629 WGDGDYGKLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG--- 684
G +G+LG G C P+ IE L VV + G + ++A T G V+ WG G
Sbjct: 125 CGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLAS 183
Query: 685 DNQRLGHGTEEHVRY----PKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
+RL G + + P + GL+ K + V AGS H +LT+ EV+ WGSN Q
Sbjct: 184 CGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQ 243
Score = 93.6 bits (231), Expect = 4e-18
Identities = 81/280 (28%), Positives = 116/280 (41%), Gaps = 67/280 (23%)
Query: 3109 SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMV----------------------- 3145
S S A ++ L+ WG YG+LG G L P+ +
Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVT 65
Query: 3146 ------------------------------KVLLGHRVIQVACGSRDAQTLALTDEGLVF 3175
K L G + QVACG T+ LT+ G V
Sbjct: 66 DGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGW--DFTIMLTENGQVL 123
Query: 3176 SWGDGDFGKLG-RGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY 3234
S G FG+LG G C +PQ IE + VC I G + ++A T SG+V+ WG G
Sbjct: 124 SCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWGTGLA 182
Query: 3235 F---RLGHGSDVHV----RKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHG 3287
RL G + + ++P V GL K + V G+ H ++TD+G+VY WG N HG
Sbjct: 183 SCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHG 242
Query: 3288 QQGNGTTTVNRKPTLVQG--LEGQKITRVACGSSHSVAWT 3325
Q N + P ++ + +K+T + G +H VA T
Sbjct: 243 QLANEAAFL-PVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
Score = 84.3 bits (207), Expect = 3e-15
Identities = 74/276 (26%), Positives = 119/276 (43%), Gaps = 23/276 (8%)
Query: 477 YNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDT--VP 534
+ D L PQ + V+ GH + G+++ G G+LG G T +P
Sbjct: 32 HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG-GDLFVCGLNKDGQLGLGHTEDIP 90
Query: 535 LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIP 594
P S F G + +ACG ++ +T G++ + G ++G+LG +
Sbjct: 91 YFTP-CKSLF-----GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV 144
Query: 595 MLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CK 646
L KV+ +A G A +A T +G V+ WG G GR G K
Sbjct: 145 PQAIELHKEKVVCIAAGLRHA--VAATASGIVFQWGTG-LASCGRRLCPGQTLPLFFTAK 201
Query: 647 TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG- 705
P + L++ + V GS S +LT G+VY WG + +L + + P+ +E
Sbjct: 202 EPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAH 260
Query: 706 -LQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Q +KV + +G TH +A TE ++ +WG D Q
Sbjct: 261 CFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQ 296
Score = 81.3 bits (199), Expect = 2e-14
Identities = 67/228 (29%), Positives = 103/228 (45%), Gaps = 12/228 (5%)
Query: 563 SAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTE 622
S A A L+ WG +YG+LG G ED +P + + + G G + VT+
Sbjct: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGG-GHSAVVTD 66
Query: 623 NGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWG 682
G ++ G G+LG G ++ + L + +V CG F+I LT++GQV S G
Sbjct: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCG 126
Query: 683 KGDNQRLG--HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN-DQC 739
+LG HG V P+ +E L +KV+ +AAG H +A T V WG+ C
Sbjct: 127 SNSFGQLGVPHGPRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASC 184
Query: 740 QH----FDTLRV--TKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781
TL + T EP+ + GL+ + + G S + + E
Sbjct: 185 GRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGE 232
Score = 79.7 bits (195), Expect = 6e-14
Identities = 75/297 (25%), Positives = 123/297 (41%), Gaps = 35/297 (11%)
Query: 3943 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTA 4002
D+T+ +G + G N GQLG G + V L + V + G + A TA
Sbjct: 111 DFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATA 170
Query: 4003 DGKLYATGYG---AGGRLGIGGTE----SVSTPTLLESIQHVFIKKVAVNSGGKHCLALS 4055
G ++ G G G RL G T + P+ + +++ K + V +G H +L+
Sbjct: 171 SGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENS--KAMCVLAGSDHSASLT 228
Query: 4056 SEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES--LRGIEVVDVAAGGAHSACVTAAGDLY 4113
GEVY WG + G+L + + P+ IE+ + +V + +G H T G ++
Sbjct: 229 DAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMF 287
Query: 4114 TWGKGRYGRLGHS---------DSEDQL---------KPKLVEALQGHRVVDIACGSGDA 4155
TWG+ YG+LG + +D P L G +++CGS
Sbjct: 288 TWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHN 345
Query: 4156 QTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVAL 4212
+ +SWG ++G G G P + +L + V CG+ S+AL
Sbjct: 346 LAII---GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
Score = 71.6 bits (174), Expect = 2e-11
Identities = 74/299 (24%), Positives = 121/299 (40%), Gaps = 45/299 (15%)
Query: 508 LALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAIT 567
+ L G+V S G G+LG VP + + + + + VV IA G ++ A T
Sbjct: 114 IMLTENGQVLSCGSNSFGQLG----VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAAT 169
Query: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPML--------VAGLKGLKVIDVACGSGDAQTLA 619
A G ++ WG G G + +P+ V GL+ K + V GS + +L
Sbjct: 170 ASGIVFQWGTG-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASL- 227
Query: 620 VTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEK--LQDLDVVKVRCGSQFSIALTKDGQ 677
T+ G+V+ WG +G+L + P+ IE Q+ V + G +A T+ G+
Sbjct: 228 -TDAGEVYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGK 285
Query: 678 VYSWGKGDNQRLGHGTEEHVRY---------------------PKLLEGLQGKKVIDVAA 716
+++WG+ D +LG E + + P L G +V+
Sbjct: 286 MFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG-----ATEVSC 340
Query: 717 GSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFA 775
GS H LA+ +SWG N+ D P + L + + + CG S A
Sbjct: 341 GSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
Score = 63.9 bits (154), Expect = 4e-09
Identities = 52/206 (25%), Positives = 86/206 (41%), Gaps = 26/206 (12%)
Query: 3974 KVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLES 4033
K P+ L + + ++ G ++T G++Y G G+L E+ P +
Sbjct: 201 KEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA---NEAAFLPVPQKI 257
Query: 4034 IQHVFI--KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRS-------------P 4078
H F K A+ SG H +A + G++++WG A+ G+LG + P
Sbjct: 258 EAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLP 317
Query: 4079 CDRP-----RVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK 4133
C RP L G +V+ G H+ + G Y+WG +G G +
Sbjct: 318 CSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA 374
Query: 4134 PKLVEALQGHRVVDIACGSGDAQTLC 4159
PK V+AL + + CG+G + LC
Sbjct: 375 PKPVQALLSSSGLLVGCGAGHSLALC 400
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 133 bits (334), Expect = 5e-30
Identities = 93/330 (28%), Positives = 158/330 (47%), Gaps = 19/330 (5%)
Query: 4468 VKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA- 4526
+ F GE D GG E I E+ N + L +P +R Y ++P++
Sbjct: 4048 IVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPG-------DRVTYTINPSSHCN 4100
Query: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
P H S F+F+G ++ A+ L +K + G S+ D+ D F GL+Y+
Sbjct: 4101 PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL 4160
Query: 4587 RDNEATSEEFEAMSLPFTVPS-----ASGQDIQLSSKHTHITLDNRAEYVRLAINYRLH- 4640
+N+ ++ ++ L F+ +D++ + + +T +N+ EYV L R+
Sbjct: 4161 LENDVSTLGYD---LTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTG 4217
Query: 4641 EFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASL 4700
+Q+AA EG ++P L+S+FT ELE ++ G P I + LKS Y + ++
Sbjct: 4218 AIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ 4277
Query: 4701 IQWFWEVMESFSNTERSLFLRFVWGRTRLP-RTIADFRGRDFVIQV-LDKYNPPDHFLPE 4758
IQWFW + SF +R+ FL+FV G +++P + A G + + + + + + LP
Sbjct: 4278 IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPS 4337
Query: 4759 SYTCFFLLKLPRYSCKQVLEEKLKYAIHFC 4788
++TCF L LP Y + L L AI C
Sbjct: 4338 AHTCFNQLDLPAYESFEKLRHMLLLAIQEC 4367
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 131 bits (330), Expect = 1e-29
Identities = 84/269 (31%), Positives = 139/269 (51%), Gaps = 12/269 (4%)
Query: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
P H + FRF G +LG+A+ +++ +K + G+ + D++ +D ++ L +I
Sbjct: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
Query: 4587 RDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHI--TLDNRAEYVRLAINYRL-HEFD 4643
DN+ + E T + +++ L I T +N+AEYV+L R+
Sbjct: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
Query: 4644 EQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLH-LLKSVATYKGIEPSASLIQ 4702
Q+ A +G +P L+ LF YELE ++ G P+I + +K+ G E +IQ
Sbjct: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Query: 4703 WFWEVMESFSNTERSLFLRFVWGRTRLPR-TIADFRG----RDFVIQVLDKYNPPDHFLP 4757
WFWEV+E + ER L L+FV G +R+P A+ G ++F I + Y P + LP
Sbjct: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAV-PYTP--NLLP 871
Query: 4758 ESYTCFFLLKLPRYSCKQVLEEKLKYAIH 4786
S TC +LKLP Y K++L+++L A+H
Sbjct: 872 TSSTCINMLKLPEYPSKEILKDRLLVALH 900
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 130 bits (328), Expect = 2e-29
Identities = 109/409 (26%), Positives = 185/409 (45%), Gaps = 56/409 (13%)
Query: 3957 WGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4016
WG + G L G+ + V C A + L +T +GKL++ G G+
Sbjct: 137 WGPHRYGCLAGVR-VRTVVSGSCAAHSLL--------------ITTEGKLWSWGRNEKGQ 181
Query: 4017 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4076
LG G T+ V P L+E + H I V+ G H LAL+ G V+++GE + G+LG GN+
Sbjct: 182 LGHGDTKRVEAPRLIEGLSHEVI--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
Query: 4077 SPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS---------- 4126
+ G + +A G S + G+LY++G YG+LGH+
Sbjct: 240 TDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299
Query: 4127 --DSEDQLKPK----LVEALQGHRVV--------DIACGSGDAQTLCLTDDDTVWSWGDG 4172
+ + +L P+ +E + +++ D+ACG+ TL L V+SWG G
Sbjct: 300 RIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFG 357
Query: 4173 DYGKLGRGGSDGCKVP--MKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230
YG+LG VP +K+ G G ++ G S A+++ G ++ WG + R
Sbjct: 358 GYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-- 415
Query: 4231 HGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDE-GQL--GDGTTN 4287
+ P+ VQ L G ++ ++A G + ++ + +WG + G+L GD
Sbjct: 416 ----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPK 470
Query: 4288 AIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYN 4336
+ + V L G +VA G +H+L + + + + ++P EYN
Sbjct: 471 SSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLP-EYN 518
Score = 124 bits (310), Expect = 3e-27
Identities = 87/311 (27%), Positives = 148/311 (47%), Gaps = 36/311 (11%)
Query: 3036 PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA 3095
P + L+ V+ V S H+ +T +GK++SWG + G+LGH + PRLIE
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
Query: 3096 LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 3155
L + I ACG +H+ ALT +G ++ +G + G+LG G+ T + + G + +
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITK 258
Query: 3156 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG------------CN-IPQNI--- 3199
+ACG+ ++ + +G ++S+G ++G+LG S+G C +P+ +
Sbjct: 259 MACGAE--FSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 3200 --ERLNGQ-------GVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQV 3250
+ +GQ V + CGA +L L V++WG G Y RLGH P++
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 3251 VE--GLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG 3308
V+ G+ + G AV++ G ++ WG + ++ P VQ L G
Sbjct: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES------TMYPKAVQDLCG 429
Query: 3309 QKITRVACGSS 3319
+I +ACG S
Sbjct: 430 WRIRSLACGKS 440
Score = 123 bits (309), Expect = 4e-27
Identities = 100/348 (28%), Positives = 156/348 (44%), Gaps = 45/348 (12%)
Query: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015
T K++ WG N+K QLG +++ P E LS +V A G A+T G V+A
Sbjct: 166 TTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFA 225
Query: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075
GE G+LGLG + VP P QI + K G + + G ++S+G +
Sbjct: 226 FGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC---GAEFSMIMDCKGNLYSFGCPE 282
Query: 3076 DGKLGHFS-----------RMNCD-KPRLIEAL--KTKR----------IRDIACGSSHS 3111
G+LGH S +C+ PR + KTK +RD+ACG++H+
Sbjct: 283 YGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHT 342
Query: 3112 AALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV--LLGHRVIQVACGSRDAQTLALT 3169
L S +++WG G YGRLGH + ++ P++VK+ G Q+ G + A++
Sbjct: 343 LVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGY--TCSFAVS 400
Query: 3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTW 3229
+ G +F WG + + E P+ ++ L G + + CG + + +W
Sbjct: 401 EVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SW 453
Query: 3230 GKGDYF-RLGHGSDVHVRK----PQVVEGLRGKKIVHVAVGALHCLAV 3272
G F LG+G H K Q V+ L G VA+G H L +
Sbjct: 454 GPSPTFGELGYGD--HKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
Score = 117 bits (293), Expect = 3e-25
Identities = 106/369 (28%), Positives = 167/369 (45%), Gaps = 51/369 (13%)
Query: 2989 LSALNVVQVAGGSKSLFA--VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYV 3046
L+ + V V GS + + +T EGK+++ G G+LG G + V PR I LS V
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHG-DTKRVEAPRLIEGLSHEV 203
Query: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106
+ V+ G H ALT G VF++GE G+LG ++ + + I +AC
Sbjct: 204 I--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC 261
Query: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDN------------TTQLKPKMVKVLLGHR-- 3152
G+ S + G LY++G EYG+LGH + +L P+ V + +
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
Query: 3153 ----------VIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL 3202
V VACG+ TL L + VFSWG G +G+LG + +P+ ++
Sbjct: 322 GQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
Query: 3203 N--GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260
+ G+G QI G S A+++ G ++ WG + R P+ V+ L G +I
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIR 433
Query: 3261 HVAVGALHCLAVTDSGQVYAWGDN-DHGQQGNGTTTVNRKPTL------VQGLEGQKITR 3313
+A G + D + +WG + G+ G G + KP V+ L+G +
Sbjct: 434 SLACGKSSIIVAADESTI-SWGPSPTFGELGYG----DHKPKSSTAAQEVKTLDGIFSEQ 488
Query: 3314 VACGSSHSV 3322
VA G SHS+
Sbjct: 489 VAMGYSHSL 497
Score = 116 bits (291), Expect = 5e-25
Identities = 98/370 (26%), Positives = 172/370 (46%), Gaps = 54/370 (14%)
Query: 3090 PRLIEALKTKRIRDIACGS--SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV 3147
P L R+R + GS +HS +T+ G+L++WG E G+LGHGD P++++
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
Query: 3148 LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQG 3206
L ++ ACG TLALT+ G VF++G+ G+LG G +P + + NGQ
Sbjct: 199 LSHEVIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQP 255
Query: 3207 VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSD----------------------VH 3244
+ ++ CGA+FS+ + G ++++G +Y +LGH SD +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 3245 VRKPQVVEGLRGKKIV--HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTL 3302
+ K + + L +V VA GA H L + +V++WG +G+ G+ P L
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 3303 VQ--GLEGQKITRVACGSSHSVAWTTVD-----VATPSVHEPVLFQTARDPL-------- 3347
V+ G+ +++ G + S A + V AT + E ++ A L
Sbjct: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSL 435
Query: 3348 --GASYLGVPSDADSSAASNKIS----GASNSKPNRPSLAKILLSLDGNLAKQQALSHIL 3401
G S + V +D + + + G + KP + A+ + +LDG ++Q A+ +
Sbjct: 436 ACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY-- 493
Query: 3402 TALQIMYARD 3411
+ ++ ARD
Sbjct: 494 -SHSLVIARD 502
Score = 114 bits (285), Expect = 2e-24
Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 40/307 (13%)
Query: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549
LA + + + S H L + G+++SWG + G+LGHGDT +E P++I S +
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEV- 203
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
+V ACG ++ A+T G ++ +G G+LG G+ D G + +A
Sbjct: 204 ---IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMA 260
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG------------CK-TPK----LIE 652
CG+ ++ + G ++S+G +YG+LG SDG C+ P+ IE
Sbjct: 261 CGA--EFSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIE 317
Query: 653 KLQDLDVV--------KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLE 704
K +D ++ V CG+ ++ L +V+SWG G RLGH ++ P+L++
Sbjct: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
Query: 705 --GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKH 762
G+ + AG T A++E + WG+ +T R + P A+ L
Sbjct: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGAT------NTSRESTMYPKAVQDLCGWR 431
Query: 763 IVGIACG 769
I +ACG
Sbjct: 432 IRSLACG 438
Score = 102 bits (253), Expect = 1e-20
Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 30/216 (13%)
Query: 546 GKQAGKHVVHIACGS--TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
G AG V + GS +S IT EG+L++WGR G+LGHG ++ P L+ GL
Sbjct: 143 GCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
Query: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKV 662
++ ACG TLA+TE G V+++G+ G+LG G +D +P I + K+
Sbjct: 203 VIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
Query: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE-------EHVRY-------------PKL 702
CG++FS+ + G +YS+G + +LGH ++ + + Y K
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
Query: 703 LEG----LQGKKVIDVAAGSTHCLALTEDSEVHSWG 734
+G + V DVA G+ H L L V SWG
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWG 355
Score = 85.9 bits (211), Expect = 9e-16
Identities = 84/343 (24%), Positives = 140/343 (40%), Gaps = 64/343 (18%)
Query: 429 GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN---------- 478
G +G V P EGL++ + AC L L+ G V+ N
Sbjct: 180 GQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
Query: 479 SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH---GDTVPL 535
+D + + I K+A ++ + + G +YS+GC + G+LGH G +
Sbjct: 240 TDAVPSPAQIMYNGQPITKMACGAE--FSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIAR 297
Query: 536 EE---------PKVISAFSGKQAGKHVV--------HIACGSTYSAAITAEGELYTWGRG 578
+ P+ ++ F K ++ +ACG+ ++ + ++ +++WG G
Sbjct: 298 AQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
Query: 579 NYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQ-------TLAVTENGQVWSWGD 631
YGRLGH +DE +P LV K+ D G G +Q + AV+E G ++ WG
Sbjct: 358 GYGRLGHAEQKDEMVPRLV------KLFDFP-GRGASQIYAGYTCSFAVSEVGGLFFWGA 410
Query: 632 GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN-QRLG 690
+ + + PK ++ L + + CG SI + D SWG LG
Sbjct: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELG 463
Query: 691 HGTEEHVRYPKLLEGLQGKKVID------VAAGSTHCLALTED 727
+G + PK Q K +D VA G +H L + D
Sbjct: 464 YGDHK----PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
Score = 82.4 bits (202), Expect = 1e-14
Identities = 75/298 (25%), Positives = 127/298 (42%), Gaps = 38/298 (12%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPV-QLIGGEQTLFAVTAD 4003
TL+ +G+++ +G N GQL G+ VP+P + + +P+ ++ G + +
Sbjct: 214 TLALTETGSVFAFGENKMGQL-GLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCK 272
Query: 4004 GKLYATGYGAGGRLG-------IGGTESVSTP-TLLESIQHVFIKKVA------------ 4043
G LY+ G G+LG I + + L+ +FI+K
Sbjct: 273 GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
Query: 4044 --VNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--SLRGIEVVDVAAG 4099
V G H L L S+ V+SWG G+LGH + PR+++ G + AG
Sbjct: 333 RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
Query: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
S V+ G L+ WG R E + PK V+ L G R+ +ACG ++
Sbjct: 393 YTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGK---SSII 443
Query: 4160 LTDDDTVWSWGDG-DYGKLGRGG--SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214
+ D++ SWG +G+LG G ++ +L G+ +V G S+ + +
Sbjct: 444 VAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 130 bits (328), Expect = 2e-29
Identities = 109/409 (26%), Positives = 185/409 (45%), Gaps = 56/409 (13%)
Query: 3957 WGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4016
WG + G L G+ + V C A + L +T +GKL++ G G+
Sbjct: 137 WGPHRYGCLAGVR-VRTVVSGSCAAHSLL--------------ITTEGKLWSWGRNEKGQ 181
Query: 4017 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4076
LG G T+ V P L+E + H I V+ G H LAL+ G V+++GE + G+LG GN+
Sbjct: 182 LGHGDTKRVEAPRLIEGLSHEVI--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
Query: 4077 SPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS---------- 4126
+ G + +A G S + G+LY++G YG+LGH+
Sbjct: 240 TDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299
Query: 4127 --DSEDQLKPK----LVEALQGHRVV--------DIACGSGDAQTLCLTDDDTVWSWGDG 4172
+ + +L P+ +E + +++ D+ACG+ TL L V+SWG G
Sbjct: 300 RIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFG 357
Query: 4173 DYGKLGRGGSDGCKVP--MKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230
YG+LG VP +K+ G G ++ G S A+++ G ++ WG + R
Sbjct: 358 GYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-- 415
Query: 4231 HGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDE-GQL--GDGTTN 4287
+ P+ VQ L G ++ ++A G + ++ + +WG + G+L GD
Sbjct: 416 ----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPK 470
Query: 4288 AIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYN 4336
+ + V L G +VA G +H+L + + + + ++P EYN
Sbjct: 471 SSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLP-EYN 518
Score = 124 bits (310), Expect = 3e-27
Identities = 87/311 (27%), Positives = 148/311 (47%), Gaps = 36/311 (11%)
Query: 3036 PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA 3095
P + L+ V+ V S H+ +T +GK++SWG + G+LGH + PRLIE
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
Query: 3096 LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 3155
L + I ACG +H+ ALT +G ++ +G + G+LG G+ T + + G + +
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITK 258
Query: 3156 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG------------CN-IPQNI--- 3199
+ACG+ ++ + +G ++S+G ++G+LG S+G C +P+ +
Sbjct: 259 MACGAE--FSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 3200 --ERLNGQ-------GVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQV 3250
+ +GQ V + CGA +L L V++WG G Y RLGH P++
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 3251 VE--GLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG 3308
V+ G+ + G AV++ G ++ WG + ++ P VQ L G
Sbjct: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES------TMYPKAVQDLCG 429
Query: 3309 QKITRVACGSS 3319
+I +ACG S
Sbjct: 430 WRIRSLACGKS 440
Score = 123 bits (309), Expect = 4e-27
Identities = 100/348 (28%), Positives = 156/348 (44%), Gaps = 45/348 (12%)
Query: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015
T K++ WG N+K QLG +++ P E LS +V A G A+T G V+A
Sbjct: 166 TTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFA 225
Query: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075
GE G+LGLG + VP P QI + K G + + G ++S+G +
Sbjct: 226 FGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC---GAEFSMIMDCKGNLYSFGCPE 282
Query: 3076 DGKLGHFS-----------RMNCD-KPRLIEAL--KTKR----------IRDIACGSSHS 3111
G+LGH S +C+ PR + KTK +RD+ACG++H+
Sbjct: 283 YGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHT 342
Query: 3112 AALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV--LLGHRVIQVACGSRDAQTLALT 3169
L S +++WG G YGRLGH + ++ P++VK+ G Q+ G + A++
Sbjct: 343 LVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGY--TCSFAVS 400
Query: 3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTW 3229
+ G +F WG + + E P+ ++ L G + + CG + + +W
Sbjct: 401 EVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SW 453
Query: 3230 GKGDYF-RLGHGSDVHVRK----PQVVEGLRGKKIVHVAVGALHCLAV 3272
G F LG+G H K Q V+ L G VA+G H L +
Sbjct: 454 GPSPTFGELGYGD--HKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
Score = 117 bits (293), Expect = 3e-25
Identities = 106/369 (28%), Positives = 167/369 (45%), Gaps = 51/369 (13%)
Query: 2989 LSALNVVQVAGGSKSLFA--VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYV 3046
L+ + V V GS + + +T EGK+++ G G+LG G + V PR I LS V
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHG-DTKRVEAPRLIEGLSHEV 203
Query: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106
+ V+ G H ALT G VF++GE G+LG ++ + + I +AC
Sbjct: 204 I--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC 261
Query: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDN------------TTQLKPKMVKVLLGHR-- 3152
G+ S + G LY++G EYG+LGH + +L P+ V + +
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
Query: 3153 ----------VIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL 3202
V VACG+ TL L + VFSWG G +G+LG + +P+ ++
Sbjct: 322 GQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
Query: 3203 N--GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260
+ G+G QI G S A+++ G ++ WG + R P+ V+ L G +I
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIR 433
Query: 3261 HVAVGALHCLAVTDSGQVYAWGDN-DHGQQGNGTTTVNRKPTL------VQGLEGQKITR 3313
+A G + D + +WG + G+ G G + KP V+ L+G +
Sbjct: 434 SLACGKSSIIVAADESTI-SWGPSPTFGELGYG----DHKPKSSTAAQEVKTLDGIFSEQ 488
Query: 3314 VACGSSHSV 3322
VA G SHS+
Sbjct: 489 VAMGYSHSL 497
Score = 116 bits (291), Expect = 5e-25
Identities = 98/370 (26%), Positives = 172/370 (46%), Gaps = 54/370 (14%)
Query: 3090 PRLIEALKTKRIRDIACGS--SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV 3147
P L R+R + GS +HS +T+ G+L++WG E G+LGHGD P++++
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
Query: 3148 LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQG 3206
L ++ ACG TLALT+ G VF++G+ G+LG G +P + + NGQ
Sbjct: 199 LSHEVIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQP 255
Query: 3207 VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSD----------------------VH 3244
+ ++ CGA+FS+ + G ++++G +Y +LGH SD +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 3245 VRKPQVVEGLRGKKIV--HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTL 3302
+ K + + L +V VA GA H L + +V++WG +G+ G+ P L
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 3303 VQ--GLEGQKITRVACGSSHSVAWTTVD-----VATPSVHEPVLFQTARDPL-------- 3347
V+ G+ +++ G + S A + V AT + E ++ A L
Sbjct: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSL 435
Query: 3348 --GASYLGVPSDADSSAASNKIS----GASNSKPNRPSLAKILLSLDGNLAKQQALSHIL 3401
G S + V +D + + + G + KP + A+ + +LDG ++Q A+ +
Sbjct: 436 ACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY-- 493
Query: 3402 TALQIMYARD 3411
+ ++ ARD
Sbjct: 494 -SHSLVIARD 502
Score = 114 bits (285), Expect = 2e-24
Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 40/307 (13%)
Query: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549
LA + + + S H L + G+++SWG + G+LGHGDT +E P++I S +
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEV- 203
Query: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
+V ACG ++ A+T G ++ +G G+LG G+ D G + +A
Sbjct: 204 ---IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMA 260
Query: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG------------CK-TPK----LIE 652
CG+ ++ + G ++S+G +YG+LG SDG C+ P+ IE
Sbjct: 261 CGA--EFSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIE 317
Query: 653 KLQDLDVV--------KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLE 704
K +D ++ V CG+ ++ L +V+SWG G RLGH ++ P+L++
Sbjct: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
Query: 705 --GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKH 762
G+ + AG T A++E + WG+ +T R + P A+ L
Sbjct: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGAT------NTSRESTMYPKAVQDLCGWR 431
Query: 763 IVGIACG 769
I +ACG
Sbjct: 432 IRSLACG 438
Score = 102 bits (253), Expect = 1e-20
Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 30/216 (13%)
Query: 546 GKQAGKHVVHIACGS--TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
G AG V + GS +S IT EG+L++WGR G+LGHG ++ P L+ GL
Sbjct: 143 GCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
Query: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKV 662
++ ACG TLA+TE G V+++G+ G+LG G +D +P I + K+
Sbjct: 203 VIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
Query: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE-------EHVRY-------------PKL 702
CG++FS+ + G +YS+G + +LGH ++ + + Y K
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
Query: 703 LEG----LQGKKVIDVAAGSTHCLALTEDSEVHSWG 734
+G + V DVA G+ H L L V SWG
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWG 355
Score = 85.9 bits (211), Expect = 9e-16
Identities = 84/343 (24%), Positives = 140/343 (40%), Gaps = 64/343 (18%)
Query: 429 GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN---------- 478
G +G V P EGL++ + AC L L+ G V+ N
Sbjct: 180 GQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
Query: 479 SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH---GDTVPL 535
+D + + I K+A ++ + + G +YS+GC + G+LGH G +
Sbjct: 240 TDAVPSPAQIMYNGQPITKMACGAE--FSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIAR 297
Query: 536 EE---------PKVISAFSGKQAGKHVV--------HIACGSTYSAAITAEGELYTWGRG 578
+ P+ ++ F K ++ +ACG+ ++ + ++ +++WG G
Sbjct: 298 AQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
Query: 579 NYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQ-------TLAVTENGQVWSWGD 631
YGRLGH +DE +P LV K+ D G G +Q + AV+E G ++ WG
Sbjct: 358 GYGRLGHAEQKDEMVPRLV------KLFDFP-GRGASQIYAGYTCSFAVSEVGGLFFWGA 410
Query: 632 GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN-QRLG 690
+ + + PK ++ L + + CG SI + D SWG LG
Sbjct: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELG 463
Query: 691 HGTEEHVRYPKLLEGLQGKKVID------VAAGSTHCLALTED 727
+G + PK Q K +D VA G +H L + D
Sbjct: 464 YGDHK----PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
Score = 82.4 bits (202), Expect = 1e-14
Identities = 75/298 (25%), Positives = 127/298 (42%), Gaps = 38/298 (12%)
Query: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPV-QLIGGEQTLFAVTAD 4003
TL+ +G+++ +G N GQL G+ VP+P + + +P+ ++ G + +
Sbjct: 214 TLALTETGSVFAFGENKMGQL-GLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCK 272
Query: 4004 GKLYATGYGAGGRLG-------IGGTESVSTP-TLLESIQHVFIKKVA------------ 4043
G LY+ G G+LG I + + L+ +FI+K
Sbjct: 273 GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
Query: 4044 --VNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--SLRGIEVVDVAAG 4099
V G H L L S+ V+SWG G+LGH + PR+++ G + AG
Sbjct: 333 RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
Query: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
S V+ G L+ WG R E + PK V+ L G R+ +ACG ++
Sbjct: 393 YTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGK---SSII 443
Query: 4160 LTDDDTVWSWGDG-DYGKLGRGG--SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214
+ D++ SWG +G+LG G ++ +L G+ +V G S+ + +
Sbjct: 444 VAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 129 bits (324), Expect = 7e-29
Identities = 98/336 (29%), Positives = 165/336 (49%), Gaps = 15/336 (4%)
Query: 2995 VQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHS 3054
V ++ G + VT K+Y G G+LGLG S + P + AL VK A
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAAC-- 94
Query: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAA 3113
G H T G V++ G ++G+LG + +I ++ +I+ ++ GS+ SAA
Sbjct: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
Query: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
LT G L+ WG G++G + + P+ V + G V ++CG + +T +G
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY--HSAFVTTDGE 210
Query: 3174 VFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
++ +G+ + GKLG N PQ + + + V Q+ CG + ++ LT++ V +T+G
Sbjct: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTFGL 268
Query: 3232 GDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
G + +LG G+ + +P+V+E +R + I +++ G H +TD G +Y +GD HG+ G
Sbjct: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Query: 3291 NGTTTVNRK--PTLVQGLEGQKITRVACGSSHSVAW 3324
G PTL + VACG H V +
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
Score = 129 bits (324), Expect = 7e-29
Identities = 80/282 (28%), Positives = 147/282 (52%), Gaps = 10/282 (3%)
Query: 3050 VAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS 3109
V + G H+ +T + K++ +G + G+LG S+ KP ++ALK ++++ ACG +
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 3110 HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLG-HRVIQVACGSRDAQTLAL 3168
H+ T G +Y G G+LG GD + ++ H++ Q++ GS + AL
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN--TSAAL 155
Query: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
T++G +F WGD G++G +PQ + G+ V I CG S +T G ++
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 3229 WGKGDYFRLGHGSDV--HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286
+G+ + +LG + + + R PQ+V + +K++ VA G H + +T++ VY +G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTENA-VYTFGLGQF 271
Query: 3287 GQQGNGTTTV-NRKPTLVQGLEGQKITRVACGSSHSVAWTTV 3327
GQ G GT +P +++ + Q I+ ++CG +H+ T +
Sbjct: 272 GQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDI 313
Score = 129 bits (323), Expect = 9e-29
Identities = 97/337 (28%), Positives = 164/337 (48%), Gaps = 14/337 (4%)
Query: 3987 PVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS 4046
PV L G++ VT + KLY G G+LG+G ++S PT +++++ +K A
Sbjct: 37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAA--C 94
Query: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRG-IEVVDVAAGGAHSAC 4105
G H L + G VY+ G +G+LG G+ + VI ++ ++AG SA
Sbjct: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
Query: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
+T G L+ WG G++G + + P+ V G V I+CG + +T D
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGY--YHSAFVTTDGE 210
Query: 4166 VWSWGDGDYGKLGRGGS--DGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4223
++ +G+ + GKLG + P + + V++V CG + +V LT++ AVYT+G
Sbjct: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTEN-AVYTFGL 268
Query: 4224 GDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
G + +LG G+ P+ ++ ++ + + I+ G H T+ G +YT+GD G+LG
Sbjct: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Query: 4283 DGTTNAIQR--PRLVAALQGKKVNRVACGSAHTLAWS 4317
G N P L + V VACG H + ++
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
Score = 125 bits (313), Expect = 1e-27
Identities = 93/291 (31%), Positives = 147/291 (50%), Gaps = 11/291 (3%)
Query: 2953 SAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
+ T K++++G N+ QLG S I P+ + L V A G T G
Sbjct: 48 AVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGN 107
Query: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
VYA G G+LGLG + S + +K+++ +G + ALT DG++F WG
Sbjct: 108 VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS--AGSNTSAALTEDGRLFMWG 165
Query: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
+ +G++G + N P+ + K + I+CG HSA +T+ GELY +G E G+LG
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223
Query: 3133 HGDNT--TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG- 3189
+ P++V + +VIQVACG T+ LT E V+++G G FG+LG G
Sbjct: 224 LPNQLLGNHRTPQLVSE-IPEKVIQVACGGE--HTVVLT-ENAVYTFGLGQFGQLGLGTF 279
Query: 3190 SEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240
+ P+ IE + Q + I CG + +T G+++T+G G + +LG G
Sbjct: 280 LFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG 330
Score = 114 bits (286), Expect = 2e-24
Identities = 91/328 (27%), Positives = 157/328 (47%), Gaps = 16/328 (4%)
Query: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
D+ + G+ +Y +G N+ GQLG + + PT +AL + G T
Sbjct: 44 DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVST 103
Query: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLE--SIQHVFIKKVAVNSGGKHCLALSSEGE 4059
G +YATG G+LG+G TE +T ++ + +H K +++G AL+ +G
Sbjct: 104 EGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEH---KIKQLSAGSNTSAALTEDGR 160
Query: 4060 VYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGR 4119
++ WG+ +G++G N S P+ + G V ++ G HSA VT G+LY +G+
Sbjct: 161 LFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPE 218
Query: 4120 YGRLGHSDS--EDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKL 4177
G+LG + + P+LV + +V+ +ACG T+ LT ++ V+++G G +G+L
Sbjct: 219 NGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGG--EHTVVLT-ENAVYTFGLGQFGQL 274
Query: 4178 GRGG-SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH 4236
G G P I+++ + + CG + +T G +YT+G G + +LG G ++
Sbjct: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF 334
Query: 4237 VRR--PRQVQGLQGKKVIAIATGSLHCV 4262
P V +A G H V
Sbjct: 335 TNHFIPTLCSNFLRFIVKLVACGGCHMV 362
Score = 111 bits (277), Expect = 2e-23
Identities = 75/231 (32%), Positives = 118/231 (51%), Gaps = 8/231 (3%)
Query: 3104 IACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDA 3163
++CG HSA +T + +LY +G +G+LG G + KP VK L +V ACG
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-- 97
Query: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFSLALTK 3222
TL T+ G V++ G + G+LG G +E N I + + Q+ G+ S ALT+
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
Query: 3223 SGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282
G ++ WG ++G + +V PQ V GK + ++ G H VT G++Y +G
Sbjct: 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFG 215
Query: 3283 DNDHGQQG--NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVAT 3331
+ ++G+ G N +R P LV + +K+ +VACG H+V T V T
Sbjct: 216 EPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
Score = 102 bits (253), Expect = 1e-20
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 30/310 (9%)
Query: 428 WGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV 487
WG +G + + P + L V AC L+ + G VY N++ QL
Sbjct: 64 WGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG---QLG 120
Query: 488 QG-LASRNIVKIAAHSDGHHYL-----------ALAATGEVYSWGCGDGGRLGHGDTVPL 535
G RN + + H + AL G ++ WG G++G + +
Sbjct: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
Query: 536 EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS--EDEAI 593
P+ ++ GK V I+CG +SA +T +GELY +G G+LG + +
Sbjct: 181 CVPQQVTI------GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT 234
Query: 594 PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIE 652
P LV+ + KVI VACG T+ +TEN V+++G G +G+LG G PK+IE
Sbjct: 235 PQLVSEIPE-KVIQVACGG--EHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIE 290
Query: 653 KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRY--PKLLEGLQGKK 710
++D + + CG + +T G +Y++G G + +LG G E + P L
Sbjct: 291 NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350
Query: 711 VIDVAAGSTH 720
V VA G H
Sbjct: 351 VKLVACGGCH 360
Score = 98.6 bits (244), Expect = 1e-19
Identities = 70/236 (29%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 554 VHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
VH++CG +SA +T +LY +G N+G+LG GS + P V LK KV ACG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 614 DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVK-VRCGSQFSIAL 672
TL TE G V++ G + G+LG G ++ T +I +K + GS S AL
Sbjct: 98 --HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 673 TKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHS 732
T+DG+++ WG ++G +V P+ + GK V ++ G H +T D E++
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 733 WG--SNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSEWSIGL 786
+G N + + L P + + K ++ +ACG + + + ++ GL
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGGEHTVVLTENAVYTFGL 268
Score = 92.8 bits (229), Expect = 7e-18
Identities = 70/236 (29%), Positives = 119/236 (50%), Gaps = 12/236 (5%)
Query: 2944 IRKKAAGLESAATIRT--KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGS 3001
I++ +AG ++A + ++F+WG N + Q+G S + VP + V ++ G
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGY 199
Query: 3002 KSLFAVTVEGKVYACGEATNGRLGLGISS-GTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
VT +G++Y GE NG+LGL G P+ ++ + V++ V GG H
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTV 256
Query: 3061 ALTVDGKVFSWGEGDDGKLGHFSRM-NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 3119
LT + V+++G G G+LG + + +P++IE ++ + I I+CG +H+A +T G
Sbjct: 257 VLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGL 315
Query: 3120 LYTWGLGEYGRLGHG--DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
+YT+G G +G+LG G + T P + L V VACG A G+
Sbjct: 316 MYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371
Score = 70.9 bits (172), Expect = 3e-11
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 606 IDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCG 665
+ V GD + VT N +++ +G ++G+LG G P ++ L+ V CG
Sbjct: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
Query: 666 SQFSIALTKDGQVYSWGKGDNQRLGHG-TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLAL 724
++ T+ G VY+ G + +LG G TEE + + K+ ++AGS AL
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 725 TEDSEVHSWGSNDQCQ 740
TED + WG N + Q
Sbjct: 156 TEDGRLFMWGDNSEGQ 171
Score = 67.0 bits (162), Expect = 4e-10
Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 11/159 (6%)
Query: 3168 LTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVW 3227
+ D G VF++G F + N P N V + CG + S +T + ++
Sbjct: 8 MPDSGAVFTFGKSKFAE---------NNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLY 57
Query: 3228 TWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHG 3287
+G ++ +LG GS + KP V+ L+ +K+ A G H L T+ G VYA G N+ G
Sbjct: 58 MFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Query: 3288 QQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWT 3325
Q G G T ++ + KI +++ GS+ S A T
Sbjct: 118 QLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Score = 55.8 bits (133), Expect = 1e-06
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
SGAV+T+GK + G + + ++ G H T + ++Y +G
Sbjct: 11 SGAVFTFGKSKFAENNPGKF----------WFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
Query: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4314
N+ GQLG G+ +AI +P V AL+ +KV ACG HTL
Sbjct: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL 100
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 129 bits (324), Expect = 7e-29
Identities = 98/336 (29%), Positives = 165/336 (49%), Gaps = 15/336 (4%)
Query: 2995 VQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHS 3054
V ++ G + VT K+Y G G+LGLG S + P + AL VK A
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAAC-- 94
Query: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAA 3113
G H T G V++ G ++G+LG + +I ++ +I+ ++ GS+ SAA
Sbjct: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
Query: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
LT G L+ WG G++G + + P+ V + G V ++CG + +T +G
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY--HSAFVTTDGE 210
Query: 3174 VFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
++ +G+ + GKLG N PQ + + + V Q+ CG + ++ LT++ V +T+G
Sbjct: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTFGL 268
Query: 3232 GDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
G + +LG G+ + +P+V+E +R + I +++ G H +TD G +Y +GD HG+ G
Sbjct: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Query: 3291 NGTTTVNRK--PTLVQGLEGQKITRVACGSSHSVAW 3324
G PTL + VACG H V +
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
Score = 129 bits (324), Expect = 7e-29
Identities = 80/282 (28%), Positives = 147/282 (52%), Gaps = 10/282 (3%)
Query: 3050 VAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS 3109
V + G H+ +T + K++ +G + G+LG S+ KP ++ALK ++++ ACG +
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 3110 HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLG-HRVIQVACGSRDAQTLAL 3168
H+ T G +Y G G+LG GD + ++ H++ Q++ GS + AL
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN--TSAAL 155
Query: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
T++G +F WGD G++G +PQ + G+ V I CG S +T G ++
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 3229 WGKGDYFRLGHGSDV--HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286
+G+ + +LG + + + R PQ+V + +K++ VA G H + +T++ VY +G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTENA-VYTFGLGQF 271
Query: 3287 GQQGNGTTTV-NRKPTLVQGLEGQKITRVACGSSHSVAWTTV 3327
GQ G GT +P +++ + Q I+ ++CG +H+ T +
Sbjct: 272 GQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDI 313
Score = 129 bits (323), Expect = 9e-29
Identities = 97/337 (28%), Positives = 164/337 (48%), Gaps = 14/337 (4%)
Query: 3987 PVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS 4046
PV L G++ VT + KLY G G+LG+G ++S PT +++++ +K A
Sbjct: 37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAA--C 94
Query: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRG-IEVVDVAAGGAHSAC 4105
G H L + G VY+ G +G+LG G+ + VI ++ ++AG SA
Sbjct: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
Query: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
+T G L+ WG G++G + + P+ V G V I+CG + +T D
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGY--YHSAFVTTDGE 210
Query: 4166 VWSWGDGDYGKLGRGGS--DGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4223
++ +G+ + GKLG + P + + V++V CG + +V LT++ AVYT+G
Sbjct: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTEN-AVYTFGL 268
Query: 4224 GDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
G + +LG G+ P+ ++ ++ + + I+ G H T+ G +YT+GD G+LG
Sbjct: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Query: 4283 DGTTNAIQR--PRLVAALQGKKVNRVACGSAHTLAWS 4317
G N P L + V VACG H + ++
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
Score = 125 bits (313), Expect = 1e-27
Identities = 93/291 (31%), Positives = 147/291 (50%), Gaps = 11/291 (3%)
Query: 2953 SAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
+ T K++++G N+ QLG S I P+ + L V A G T G
Sbjct: 48 AVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGN 107
Query: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
VYA G G+LGLG + S + +K+++ +G + ALT DG++F WG
Sbjct: 108 VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS--AGSNTSAALTEDGRLFMWG 165
Query: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
+ +G++G + N P+ + K + I+CG HSA +T+ GELY +G E G+LG
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223
Query: 3133 HGDNT--TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG- 3189
+ P++V + +VIQVACG T+ LT E V+++G G FG+LG G
Sbjct: 224 LPNQLLGNHRTPQLVSE-IPEKVIQVACGGE--HTVVLT-ENAVYTFGLGQFGQLGLGTF 279
Query: 3190 SEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240
+ P+ IE + Q + I CG + +T G+++T+G G + +LG G
Sbjct: 280 LFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG 330
Score = 114 bits (286), Expect = 2e-24
Identities = 91/328 (27%), Positives = 157/328 (47%), Gaps = 16/328 (4%)
Query: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
D+ + G+ +Y +G N+ GQLG + + PT +AL + G T
Sbjct: 44 DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVST 103
Query: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLE--SIQHVFIKKVAVNSGGKHCLALSSEGE 4059
G +YATG G+LG+G TE +T ++ + +H K +++G AL+ +G
Sbjct: 104 EGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEH---KIKQLSAGSNTSAALTEDGR 160
Query: 4060 VYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGR 4119
++ WG+ +G++G N S P+ + G V ++ G HSA VT G+LY +G+
Sbjct: 161 LFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPE 218
Query: 4120 YGRLGHSDS--EDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKL 4177
G+LG + + P+LV + +V+ +ACG T+ LT ++ V+++G G +G+L
Sbjct: 219 NGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGG--EHTVVLT-ENAVYTFGLGQFGQL 274
Query: 4178 GRGG-SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH 4236
G G P I+++ + + CG + +T G +YT+G G + +LG G ++
Sbjct: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF 334
Query: 4237 VRR--PRQVQGLQGKKVIAIATGSLHCV 4262
P V +A G H V
Sbjct: 335 TNHFIPTLCSNFLRFIVKLVACGGCHMV 362
Score = 111 bits (277), Expect = 2e-23
Identities = 75/231 (32%), Positives = 118/231 (51%), Gaps = 8/231 (3%)
Query: 3104 IACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDA 3163
++CG HSA +T + +LY +G +G+LG G + KP VK L +V ACG
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-- 97
Query: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFSLALTK 3222
TL T+ G V++ G + G+LG G +E N I + + Q+ G+ S ALT+
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
Query: 3223 SGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282
G ++ WG ++G + +V PQ V GK + ++ G H VT G++Y +G
Sbjct: 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFG 215
Query: 3283 DNDHGQQG--NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVAT 3331
+ ++G+ G N +R P LV + +K+ +VACG H+V T V T
Sbjct: 216 EPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
Score = 102 bits (253), Expect = 1e-20
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 30/310 (9%)
Query: 428 WGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV 487
WG +G + + P + L V AC L+ + G VY N++ QL
Sbjct: 64 WGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG---QLG 120
Query: 488 QG-LASRNIVKIAAHSDGHHYL-----------ALAATGEVYSWGCGDGGRLGHGDTVPL 535
G RN + + H + AL G ++ WG G++G + +
Sbjct: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
Query: 536 EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS--EDEAI 593
P+ ++ GK V I+CG +SA +T +GELY +G G+LG + +
Sbjct: 181 CVPQQVTI------GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT 234
Query: 594 PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIE 652
P LV+ + KVI VACG T+ +TEN V+++G G +G+LG G PK+IE
Sbjct: 235 PQLVSEIPE-KVIQVACGG--EHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIE 290
Query: 653 KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRY--PKLLEGLQGKK 710
++D + + CG + +T G +Y++G G + +LG G E + P L
Sbjct: 291 NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350
Query: 711 VIDVAAGSTH 720
V VA G H
Sbjct: 351 VKLVACGGCH 360
Score = 98.6 bits (244), Expect = 1e-19
Identities = 70/236 (29%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 554 VHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
VH++CG +SA +T +LY +G N+G+LG GS + P V LK KV ACG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 614 DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVK-VRCGSQFSIAL 672
TL TE G V++ G + G+LG G ++ T +I +K + GS S AL
Sbjct: 98 --HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 673 TKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHS 732
T+DG+++ WG ++G +V P+ + GK V ++ G H +T D E++
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 733 WG--SNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSEWSIGL 786
+G N + + L P + + K ++ +ACG + + + ++ GL
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGGEHTVVLTENAVYTFGL 268
Score = 92.8 bits (229), Expect = 7e-18
Identities = 70/236 (29%), Positives = 119/236 (50%), Gaps = 12/236 (5%)
Query: 2944 IRKKAAGLESAATIRT--KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGS 3001
I++ +AG ++A + ++F+WG N + Q+G S + VP + V ++ G
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGY 199
Query: 3002 KSLFAVTVEGKVYACGEATNGRLGLGISS-GTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
VT +G++Y GE NG+LGL G P+ ++ + V++ V GG H
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTV 256
Query: 3061 ALTVDGKVFSWGEGDDGKLGHFSRM-NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 3119
LT + V+++G G G+LG + + +P++IE ++ + I I+CG +H+A +T G
Sbjct: 257 VLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGL 315
Query: 3120 LYTWGLGEYGRLGHG--DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
+YT+G G +G+LG G + T P + L V VACG A G+
Sbjct: 316 MYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371
Score = 70.9 bits (172), Expect = 3e-11
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 606 IDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCG 665
+ V GD + VT N +++ +G ++G+LG G P ++ L+ V CG
Sbjct: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
Query: 666 SQFSIALTKDGQVYSWGKGDNQRLGHG-TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLAL 724
++ T+ G VY+ G + +LG G TEE + + K+ ++AGS AL
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
Query: 725 TEDSEVHSWGSNDQCQ 740
TED + WG N + Q
Sbjct: 156 TEDGRLFMWGDNSEGQ 171
Score = 67.0 bits (162), Expect = 4e-10
Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 11/159 (6%)
Query: 3168 LTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVW 3227
+ D G VF++G F + N P N V + CG + S +T + ++
Sbjct: 8 MPDSGAVFTFGKSKFAE---------NNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLY 57
Query: 3228 TWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHG 3287
+G ++ +LG GS + KP V+ L+ +K+ A G H L T+ G VYA G N+ G
Sbjct: 58 MFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Query: 3288 QQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWT 3325
Q G G T ++ + KI +++ GS+ S A T
Sbjct: 118 QLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Score = 55.8 bits (133), Expect = 1e-06
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
SGAV+T+GK + G + + ++ G H T + ++Y +G
Sbjct: 11 SGAVFTFGKSKFAENNPGKF----------WFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
Query: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4314
N+ GQLG G+ +AI +P V AL+ +KV ACG HTL
Sbjct: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL 100
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 128 bits (322), Expect = 1e-28
Identities = 96/332 (28%), Positives = 164/332 (49%), Gaps = 27/332 (8%)
Query: 4468 VKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAP 4527
VKF GE D GG E + +C E+ N L + + N D + P
Sbjct: 430 VKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI------NP 483
Query: 4528 VHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIR 4587
H S F F+G ++G+A+ G ++ P +KQL G + ++DL VD + L++I
Sbjct: 484 DHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWIL 543
Query: 4588 DNEATSEEFEAMSLPFTVP-SASGQ----DIQLSSKHTHITLDNRAEYVRLAINYR-LHE 4641
+N+ T + F V +A G+ +++ + ++ +T +N+ EYVRL +N+R +
Sbjct: 544 ENDITP----VLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRG 599
Query: 4642 FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLI 4701
+ Q A+++G ++P LL F ELE ++ G I L+ KS K ++++
Sbjct: 600 IEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIV 659
Query: 4702 QWFWEVMESFSNTERSLFLRFVWGRTRLP----RTIADFRG----RDFVIQVLDKYNPPD 4753
+WFW+ +E+F R+ L+FV G TR+P + + G R F I ++D
Sbjct: 660 RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDN- 718
Query: 4754 HFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
LP+++TCF + +P Y + L EKL A+
Sbjct: 719 --LPKAHTCFNRIDIPPYESYEKLYEKLLTAV 748
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 128 bits (322), Expect = 1e-28
Identities = 96/332 (28%), Positives = 164/332 (49%), Gaps = 27/332 (8%)
Query: 4468 VKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAP 4527
VKF GE D GG E + +C E+ N L + + N D + P
Sbjct: 404 VKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI------NP 457
Query: 4528 VHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIR 4587
H S F F+G ++G+A+ G ++ P +KQL G + ++DL VD + L++I
Sbjct: 458 DHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWIL 517
Query: 4588 DNEATSEEFEAMSLPFTVP-SASGQ----DIQLSSKHTHITLDNRAEYVRLAINYR-LHE 4641
+N+ T + F V +A G+ +++ + ++ +T +N+ EYVRL +N+R +
Sbjct: 518 ENDITP----VLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRG 573
Query: 4642 FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLI 4701
+ Q A+++G ++P LL F ELE ++ G I L+ KS K ++++
Sbjct: 574 IEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIV 633
Query: 4702 QWFWEVMESFSNTERSLFLRFVWGRTRLP----RTIADFRG----RDFVIQVLDKYNPPD 4753
+WFW+ +E+F R+ L+FV G TR+P + + G R F I ++D
Sbjct: 634 RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDN- 692
Query: 4754 HFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785
LP+++TCF + +P Y + L EKL A+
Sbjct: 693 --LPKAHTCFNRIDIPPYESYEKLYEKLLTAV 722
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 127 bits (320), Expect = 2e-28
Identities = 91/323 (28%), Positives = 150/323 (46%), Gaps = 20/323 (6%)
Query: 4472 GESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA-PVHS 4530
GE D GG E + E+ N + L + +G N C ++PA+ P H
Sbjct: 111 GEEGLDYGGIAREWFFLLSHEVLNPMYCLF-------EYAGKNNYCLQINPASSINPDHL 163
Query: 4531 SMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDN- 4589
+ FRF+G + +A+ G + P +K++ T+ DL +D +F +++I++N
Sbjct: 164 TYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENN 223
Query: 4590 -EATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHE-FDEQVA 4647
E E + + + +++ + +T +N+ EY+ L ++R +EQ
Sbjct: 224 LEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTK 283
Query: 4648 AVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEV 4707
A +G V P+ L F ELE M+CG +I + + Y+ ++ IQWFW+V
Sbjct: 284 AFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQV 343
Query: 4708 MESFSNTERSLFLRFVWGRTRLP-----RTIADFRGRDFVIQVLDKYNPPDHFLPESYTC 4762
++ N +R L+FV G RLP I + F I + K + +LP S+TC
Sbjct: 344 VKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGK----ETWLPRSHTC 399
Query: 4763 FFLLKLPRYSCKQVLEEKLKYAI 4785
F L LP Y + L EKL YAI
Sbjct: 400 FNRLDLPPYKSYEQLREKLLYAI 422
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 189,743,891
Number of Sequences: 37866
Number of extensions: 8932741
Number of successful extensions: 29407
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 26025
Number of HSP's gapped (non-prelim): 1027
length of query: 4834
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4710
effective length of database: 13,552,134
effective search space: 63830551140
effective search space used: 63830551140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.