Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 42490749
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
(753 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 1484 0.0
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 470 e-132
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 225 1e-58
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 214 2e-55
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 214 2e-55
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 208 2e-53
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 207 2e-53
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 202 9e-52
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 200 4e-51
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 199 1e-50
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 191 3e-48
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 191 3e-48
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 189 8e-48
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 186 9e-47
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 163 5e-40
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 163 5e-40
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 152 8e-37
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 152 1e-36
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 149 9e-36
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 149 9e-36
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 145 1e-34
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 143 5e-34
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 143 5e-34
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 142 9e-34
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 142 9e-34
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 142 9e-34
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 142 9e-34
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 138 2e-32
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 132 1e-30
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 132 2e-30
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 1484 bits (3841), Expect = 0.0
Identities = 753/753 (100%), Positives = 753/753 (100%)
Query: 1 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE 60
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
Sbjct: 1 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE 60
Query: 61 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK 120
SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
Sbjct: 61 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK 120
Query: 121 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS 180
IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
Sbjct: 121 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS 180
Query: 181 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 240
DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
Sbjct: 181 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 240
Query: 241 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 300
FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
Sbjct: 241 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 300
Query: 301 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 360
TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
Sbjct: 301 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 360
Query: 361 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 420
LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
Sbjct: 361 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 420
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
Sbjct: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
Query: 481 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 540
EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
Sbjct: 481 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 540
Query: 541 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 600
SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
Sbjct: 541 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 600
Query: 601 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 660
TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
Sbjct: 601 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 660
Query: 661 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 720
SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
Sbjct: 661 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 720
Query: 721 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 753
WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
Sbjct: 721 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 753
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 470 bits (1209), Expect = e-132
Identities = 256/610 (41%), Positives = 380/610 (62%), Gaps = 20/610 (3%)
Query: 117 DTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNM 176
D + ++ + Y+WP+ P L+ V I LG +G +A+N++VP ++ V+ L +
Sbjct: 241 DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEK---- 296
Query: 177 LNLSDAP-NTVA-TMATAVLIGY--GVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFL 232
AP N++A T+ + V + + G F + +R ++ +V Q + RR+ +F
Sbjct: 297 -----APWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFS 351
Query: 233 HLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKC-- 290
HLH L L +HL R+TG + + DRGT ++ +LS LVFN++P + ++++ G++Y+
Sbjct: 352 HLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIII--GIIYFSMFF 409
Query: 291 GAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNE 350
A F L+ + Y T+ VT WRT+FR MN +N A+DSLLN+ETVKY+N E
Sbjct: 410 NAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469
Query: 351 RYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGD 410
YE +RY + Y+ KS+++L +LN Q+ + +GL A +L + + L VGD
Sbjct: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529
Query: 411 LVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQT 470
V+ + QL +PLN+ GT YR + IDM +F LLK +T++KD A PL+ Q
Sbjct: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRF--QK 587
Query: 471 ATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI 530
+ F+NVHF Y +G++ L +SF V G+ +A+VG SG+GKSTI+RLLFRFY+ G I
Sbjct: 588 GRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 647
Query: 531 YLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHD 590
+ GQ+I V+ SLR +GVVPQD VLF++TI N+ YG ++A +EV A A+ AG+HD
Sbjct: 648 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
Query: 591 AILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILG 650
AI+ P GY TQVGERGLKLSGGEKQRVAIAR ILK P +IL DEATS+LD+ E I
Sbjct: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
Query: 651 AMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
++ V +RT+I +AHRLSTVV+AD+I+V+ G + ERG H LL+ +Y++MW Q
Sbjct: 768 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSR-GGVYADMWQLQQ 826
Query: 711 SRVQNHDNPK 720
+ + ++ K
Sbjct: 827 GQEETSEDTK 836
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 225 bits (573), Expect = 1e-58
Identities = 170/580 (29%), Positives = 285/580 (49%), Gaps = 20/580 (3%)
Query: 138 RARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGY 197
R R+A ++GFL + +++ PF +D + + ++ SD + +AV +
Sbjct: 168 RRRLAAAVGFLTMSSVISMSAPFFLGKIIDVI--YTNPTVDYSDNLTRLCLGLSAVFL-- 223
Query: 198 GVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRG 257
GAA N +R + Q + R+ ++F + ++ F +TG L +
Sbjct: 224 ----CGAAA-NAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSD 278
Query: 258 TRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRT 317
T + ++ + + L + + ++++ A L + + V R+
Sbjct: 279 TALLGRSVTENLSDGLRAGAQASVGISMMFF-VSPNLATFVLSVVPPVSIIAVIYGRYLR 337
Query: 318 RFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAM 377
+ + A A + + N TV+ F E E ++Y K L A
Sbjct: 338 KLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYAS--KVDHVMQLARKEAFAR 395
Query: 378 LNFGQSAIFSVGLTAIMVLASQGIVAGT--LTVGDLVMVNGLLFQLSLPLNFLGTVYRET 435
F + S L + VL G++ G+ +TVG+L F + + + L + Y E
Sbjct: 396 AGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSEL 455
Query: 436 RQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGIS 493
+ L L+ LL+ + ++ + + Q A + F NVHF Y +V S
Sbjct: 456 MKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGA-LEFKNVHFAYPARPEVPIFQDFS 514
Query: 494 FEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVP 553
+P+G A+VG SGSGKST++ LL R Y+P G+I L G +I+ ++ LR +G V
Sbjct: 515 LSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVS 574
Query: 554 QDAVLFHNTIYYNLLYGN---ISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKL 610
Q+ +LF +I N+ YG S + EE+ VA++A I P G++T VGE+G+ L
Sbjct: 575 QEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLL 634
Query: 611 SGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLST 670
SGG+KQR+AIARA+LK+P ++L DEATS+LD+ E + A+ ++ RT + IAHRLST
Sbjct: 635 SGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLST 694
Query: 671 VVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
+ +A+ + VLDQGK+ E G H LL+ P+ IY ++ + QS
Sbjct: 695 IKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 214 bits (545), Expect = 2e-55
Identities = 177/602 (29%), Positives = 292/602 (48%), Gaps = 38/602 (6%)
Query: 122 IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSD 181
++ +LSY +PD+ VA S FL A +P+ A+D + + +M S
Sbjct: 174 LQKLLSYT----KPDVAFLVAASF-FLIVAALGETFLPYYTGRAIDGI-VIQKSMDQFST 227
Query: 182 APNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241
A V +A G++F +R +F + R+ +F L + + F
Sbjct: 228 AVVIVCLLAI-----------GSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSF 276
Query: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301
+TG L + T +S ++S N+ + + V+GV+ + F+L +
Sbjct: 277 FDENRTGDLISRLTSDTTMVSDLVSQ---NINVFLRNTVKVTGVVVF----MFSLSWQLS 329
Query: 302 LGTYTAFTVAVT------RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQ 355
L T+ F + + ++ R E+ A A N A +++ +TV+ F NE EA+
Sbjct: 330 LVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAE 389
Query: 356 RYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVN 415
Y L+ + K + +G V +I+ +++G +T G+L+
Sbjct: 390 VYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFI 449
Query: 416 GLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL-KVDTQIKDKVMASPLQITPQTATVA 474
F L + +G+VY Q + +F + + T + D +A V
Sbjct: 450 IYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPD----HLEGRVD 505
Query: 475 FDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL 532
F+NV F Y +VL +SF + GK A+VG SGSGKS+ V +L FY + G + L
Sbjct: 506 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL 565
Query: 533 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAI 592
G+ I + L R + +V Q+ VLF +I N+ YG + E V A+ A H I
Sbjct: 566 DGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFI 625
Query: 593 LRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM 652
+ + GY T+ GE+G +LSGG+KQRVA+ARA++++PPV++ DEATS+LD+ +E I A+
Sbjct: 626 MELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAI 685
Query: 653 KDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSR 712
++ T + IAHRLSTV A I+VLD+G+V ++GTH LLA +Y+++ Q
Sbjct: 686 HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLG 744
Query: 713 VQ 714
+Q
Sbjct: 745 LQ 746
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 214 bits (545), Expect = 2e-55
Identities = 177/602 (29%), Positives = 292/602 (48%), Gaps = 38/602 (6%)
Query: 122 IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSD 181
++ +LSY +PD+ VA S FL A +P+ A+D + + +M S
Sbjct: 174 LQKLLSYT----KPDVAFLVAASF-FLIVAALGETFLPYYTGRAIDGI-VIQKSMDQFST 227
Query: 182 APNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241
A V +A G++F +R +F + R+ +F L + + F
Sbjct: 228 AVVIVCLLAI-----------GSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSF 276
Query: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301
+TG L + T +S ++S N+ + + V+GV+ + F+L +
Sbjct: 277 FDENRTGDLISRLTSDTTMVSDLVSQ---NINVFLRNTVKVTGVVVF----MFSLSWQLS 329
Query: 302 LGTYTAFTVAVT------RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQ 355
L T+ F + + ++ R E+ A A N A +++ +TV+ F NE EA+
Sbjct: 330 LVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAE 389
Query: 356 RYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVN 415
Y L+ + K + +G V +I+ +++G +T G+L+
Sbjct: 390 VYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFI 449
Query: 416 GLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL-KVDTQIKDKVMASPLQITPQTATVA 474
F L + +G+VY Q + +F + + T + D +A V
Sbjct: 450 IYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPD----HLEGRVD 505
Query: 475 FDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL 532
F+NV F Y +VL +SF + GK A+VG SGSGKS+ V +L FY + G + L
Sbjct: 506 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL 565
Query: 533 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAI 592
G+ I + L R + +V Q+ VLF +I N+ YG + E V A+ A H I
Sbjct: 566 DGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFI 625
Query: 593 LRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM 652
+ + GY T+ GE+G +LSGG+KQRVA+ARA++++PPV++ DEATS+LD+ +E I A+
Sbjct: 626 MELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAI 685
Query: 653 KDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSR 712
++ T + IAHRLSTV A I+VLD+G+V ++GTH LLA +Y+++ Q
Sbjct: 686 HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLG 744
Query: 713 VQ 714
+Q
Sbjct: 745 LQ 746
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 208 bits (529), Expect = 2e-53
Identities = 167/596 (28%), Positives = 278/596 (46%), Gaps = 43/596 (7%)
Query: 168 SLNQMSGNMLNLSDAPNTVATM-----ATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNS 222
+L + N+ N SD +T M T Y AG ++ + + A
Sbjct: 84 NLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQ 143
Query: 223 IRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLS---ALVFNLLPIMFEV 279
I +I K F + ++G+ G L+ + I+ + + F + F
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 280 MLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLL 339
+V + G + LV L + + F + A AG A + L
Sbjct: 204 FIVG----FTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLA 259
Query: 340 NYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQ 399
TV F ++ E +RY+ L+ + +K T A S+G +++ AS
Sbjct: 260 AIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT---------ANISIGAAFLLIYASY 310
Query: 400 G---------IVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLK 450
+++G ++G ++ V F + + +G + + K
Sbjct: 311 ALAFWYGTTLVLSGEYSIGQVLTV---FFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 367
Query: 451 V--DTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVG 506
+ + D S + + F NVHF Y + K+L G++ +V +G+ VA+VG
Sbjct: 368 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
Query: 507 GSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYN 566
SG GKST V+L+ R Y+P +G + + GQ+I+ +++ LR +GVV Q+ VLF TI N
Sbjct: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
Query: 567 LLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILK 626
+ YG + + +E+ K A +D I+++PH +DT VGERG +LSGG+KQR+AIARA+++
Sbjct: 488 IRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVR 547
Query: 627 DPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVA 686
+P ++L DEATS+LD+ +E + A+ K RT+I IAHRLSTV +AD I D G +
Sbjct: 548 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 607
Query: 687 ERGTHHGLLANPHSIYSEMWHTQSS----RVQN-HDNPKWEAKKENISKEEERKKL 737
E+G H L+ IY ++ Q++ ++N D K E +S + R L
Sbjct: 608 EKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 662
Score = 198 bits (503), Expect = 2e-50
Identities = 154/512 (30%), Positives = 252/512 (49%), Gaps = 29/512 (5%)
Query: 215 FGKVAQNSIRRIAKNVFLHLHNLDLGFH--LSRQTGALSKAIDRGTRGISFVLSALVFNL 272
FGK + +R+ VF + D+ + TGAL+ + + V A+ L
Sbjct: 777 FGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRL---ANDAAQVKGAIGSRL 833
Query: 273 LPIMFEVM-LVSGVLY-YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDA 330
I + L +G++ + G Q L+ L + V + + ++ K +
Sbjct: 834 AVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS 893
Query: 331 GNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTS--------TLAMLNFGQ 382
G A +++ N+ TV E+ Y L+ SL+ T AM+ F
Sbjct: 894 GKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSY 953
Query: 383 SAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDM 442
+ F G + ++ D+++V + ++ + + + + +A I
Sbjct: 954 AGCFRFGAYLV--------AHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISA 1005
Query: 443 NTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQK--VLSGISFEVPAGK 500
+ +++ T + D L V F V F Y VL G+S EV G+
Sbjct: 1006 AHIIMIIE-KTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQ 1064
Query: 501 KVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFH 560
+A+VG SG GKST+V+LL RFY+P G + L G+ I+ ++++ LR +G+V Q+ +LF
Sbjct: 1065 TLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFD 1124
Query: 561 NTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRV 618
+I N+ YG+ S S EE+ AK A +H I +P+ Y T+VG++G +LSGG+KQR+
Sbjct: 1125 CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRI 1184
Query: 619 AIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEII 678
AIARA+++ P ++L DEATS+LD+ +E+ + A+ + RT I IAHRLST+ +AD I+
Sbjct: 1185 AIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1244
Query: 679 VLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
V G+V E GTH LLA IY M Q+
Sbjct: 1245 VFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1275
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 207 bits (528), Expect = 2e-53
Identities = 156/513 (30%), Positives = 253/513 (49%), Gaps = 31/513 (6%)
Query: 215 FGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQ--TGALSKAIDRGT---RGISFVLSALV 269
FGK + RR+ F + D+ + + TGALS + +G + AL+
Sbjct: 776 FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALI 835
Query: 270 FNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND 329
+ + +++S + G Q L+ L + + + K
Sbjct: 836 AQNIANLGTGIIISFIY----GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
Query: 330 AGNAAIDSLLNYETVKYFNNER-----YEAQRYDGFLKTYETASLKSTS---TLAMLNFG 381
AG A +++ N TV ER Y + Y + + + A + + + A + F
Sbjct: 892 AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFS 951
Query: 382 QSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALID 441
+ F G I V G + D+++V + ++ L + + +A +
Sbjct: 952 YAGCFRFGAYLI--------VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLS 1003
Query: 442 MNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGISFEVPAG 499
LF L + I D L+ + F+ V F Y V L G+S EV G
Sbjct: 1004 AAHLFMLFERQPLI-DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKG 1062
Query: 500 KKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLF 559
+ +A+VG SG GKST+V+LL RFY+P G++ L GQ + ++++ LR +G+V Q+ +LF
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
Query: 560 HNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQR 617
+I N+ YG+ S S +E+ + AK A +H I +PH Y+T+VG++G +LSGG+KQR
Sbjct: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
Query: 618 VAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEI 677
+AIARA+++ P ++L DEATS+LD+ +E+ + A+ + RT I IAHRLST+ +AD I
Sbjct: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
Query: 678 IVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
+V G+V E GTH LLA IY M Q+
Sbjct: 1243 VVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1274
Score = 200 bits (509), Expect = 4e-51
Identities = 173/651 (26%), Positives = 301/651 (46%), Gaps = 55/651 (8%)
Query: 95 TCWHGHAGGG---LHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFL--- 148
T W + G L K+ K T K+I + + + D + ++ +SLG +
Sbjct: 10 TAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYS----DWQDKLFMSLGTIMAI 65
Query: 149 ---GGAKAMNIVVPFMFKYAVDSLNQMSGNM---LNLSDAPNTVATMATAVLIGYGVSRA 202
G M IV M VD+ S + L+L + + T Y A
Sbjct: 66 AHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGA 125
Query: 203 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS 262
G ++ + + A IR+I + F + ++G+ T L+ + IS
Sbjct: 126 GVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKIS 185
Query: 263 FVLS---ALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWR--- 316
+ + F + F +V + +K +TL + ++ W
Sbjct: 186 EGIGDKVGMFFQAVATFFAGFIVGFIRGWK-------LTLVIMAISPILGLSAAVWAKIL 238
Query: 317 TRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTST-- 374
+ F + A AG A ++L TV F + E +RY L+ + +K +
Sbjct: 239 SAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
Query: 375 ----LAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPL----- 425
+A L S + + +V++ + + +TV +++ + P
Sbjct: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
Query: 426 NFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE- 484
N G Y +F ++ + +I D + + F++VHF Y
Sbjct: 359 NARGAAY-----------VIFDIIDNNPKI-DSFSERGHKPDSIKGNLEFNDVHFSYPSR 406
Query: 485 -GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543
K+L G++ +V +G+ VA+VG SG GKST V+L+ R Y+P +G+I + GQ+I++ ++
Sbjct: 407 ANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVN 466
Query: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603
LR +GVV Q+ VLF TI N+ YG + + +E+ K A ++ I+++P +DT V
Sbjct: 467 YLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
Query: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIF 663
GERG +LSGG+KQR+AIARA++++P ++L DEATS+LD+ +E + A+ + RT+I
Sbjct: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 664 IAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ 714
IAHRLSTV +AD I + G + E+G+H L+ +Y ++ + Q+S Q
Sbjct: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLVNMQTSGSQ 636
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 202 bits (514), Expect = 9e-52
Identities = 156/520 (30%), Positives = 254/520 (48%), Gaps = 38/520 (7%)
Query: 215 FGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQ--TGALSKAIDRGT---RGISFVLSALV 269
FGK + RR+ F + D+ + + TGALS + +G + AL+
Sbjct: 776 FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALI 835
Query: 270 FNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND 329
+ + +++S + G Q L+ L + + + K
Sbjct: 836 AQNIANLGTGIIISFIY----GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
Query: 330 AGNAAIDSLLNYETVKYFNNER-----YEAQRYDGFLKTYETASLKSTS---TLAMLNFG 381
AG A +++ N TV ER Y + Y + + + A + + + A + F
Sbjct: 892 AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFS 951
Query: 382 QSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALID 441
+ F G I V G + D+++V + ++ L + + +A +
Sbjct: 952 YAGCFRFGAYLI--------VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLS 1003
Query: 442 MNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGISFEVPAG 499
LF L + I D L+ + F+ V F Y V L G+S EV G
Sbjct: 1004 AAHLFMLFERQPLI-DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKG 1062
Query: 500 KKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY-------LAGQNIQDVSLESLRRAVGVV 552
+ +A+VG SG GKST+V+LL RFY+P G+++ L GQ + ++++ LR +G+V
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
Query: 553 PQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKL 610
Q+ +LF +I N+ YG+ S S +E+ + AK A +H I +PH Y+T+VG++G +L
Sbjct: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Query: 611 SGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLST 670
SGG+KQR+AIARA+++ P ++L DEATS+LD+ +E+ + A+ + RT I IAHRLST
Sbjct: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
Query: 671 VVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
+ +AD I+V G+V E GTH LLA IY M Q+
Sbjct: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1281
Score = 200 bits (509), Expect = 4e-51
Identities = 173/651 (26%), Positives = 301/651 (46%), Gaps = 55/651 (8%)
Query: 95 TCWHGHAGGG---LHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFL--- 148
T W + G L K+ K T K+I + + + D + ++ +SLG +
Sbjct: 10 TAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYS----DWQDKLFMSLGTIMAI 65
Query: 149 ---GGAKAMNIVVPFMFKYAVDSLNQMSGNM---LNLSDAPNTVATMATAVLIGYGVSRA 202
G M IV M VD+ S + L+L + + T Y A
Sbjct: 66 AHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGA 125
Query: 203 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS 262
G ++ + + A IR+I + F + ++G+ T L+ + IS
Sbjct: 126 GVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKIS 185
Query: 263 FVLS---ALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWR--- 316
+ + F + F +V + +K +TL + ++ W
Sbjct: 186 EGIGDKVGMFFQAVATFFAGFIVGFIRGWK-------LTLVIMAISPILGLSAAVWAKIL 238
Query: 317 TRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTST-- 374
+ F + A AG A ++L TV F + E +RY L+ + +K +
Sbjct: 239 SAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
Query: 375 ----LAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPL----- 425
+A L S + + +V++ + + +TV +++ + P
Sbjct: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
Query: 426 NFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE- 484
N G Y +F ++ + +I D + + F++VHF Y
Sbjct: 359 NARGAAY-----------VIFDIIDNNPKI-DSFSERGHKPDSIKGNLEFNDVHFSYPSR 406
Query: 485 -GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543
K+L G++ +V +G+ VA+VG SG GKST V+L+ R Y+P +G+I + GQ+I++ ++
Sbjct: 407 ANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVN 466
Query: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603
LR +GVV Q+ VLF TI N+ YG + + +E+ K A ++ I+++P +DT V
Sbjct: 467 YLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
Query: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIF 663
GERG +LSGG+KQR+AIARA++++P ++L DEATS+LD+ +E + A+ + RT+I
Sbjct: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 664 IAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ 714
IAHRLSTV +AD I + G + E+G+H L+ +Y ++ + Q+S Q
Sbjct: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLVNMQTSGSQ 636
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 200 bits (509), Expect = 4e-51
Identities = 173/651 (26%), Positives = 301/651 (46%), Gaps = 55/651 (8%)
Query: 95 TCWHGHAGGG---LHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFL--- 148
T W + G L K+ K T K+I + + + D + ++ +SLG +
Sbjct: 10 TAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYS----DWQDKLFMSLGTIMAI 65
Query: 149 ---GGAKAMNIVVPFMFKYAVDSLNQMSGNM---LNLSDAPNTVATMATAVLIGYGVSRA 202
G M IV M VD+ S + L+L + + T Y A
Sbjct: 66 AHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGA 125
Query: 203 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS 262
G ++ + + A IR+I + F + ++G+ T L+ + IS
Sbjct: 126 GVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKIS 185
Query: 263 FVLS---ALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWR--- 316
+ + F + F +V + +K +TL + ++ W
Sbjct: 186 EGIGDKVGMFFQAVATFFAGFIVGFIRGWK-------LTLVIMAISPILGLSAAVWAKIL 238
Query: 317 TRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTST-- 374
+ F + A AG A ++L TV F + E +RY L+ + +K +
Sbjct: 239 SAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
Query: 375 ----LAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPL----- 425
+A L S + + +V++ + + +TV +++ + P
Sbjct: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
Query: 426 NFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE- 484
N G Y +F ++ + +I D + + F++VHF Y
Sbjct: 359 NARGAAY-----------VIFDIIDNNPKI-DSFSERGHKPDSIKGNLEFNDVHFSYPSR 406
Query: 485 -GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543
K+L G++ +V +G+ VA+VG SG GKST V+L+ R Y+P +G+I + GQ+I++ ++
Sbjct: 407 ANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVN 466
Query: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603
LR +GVV Q+ VLF TI N+ YG + + +E+ K A ++ I+++P +DT V
Sbjct: 467 YLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
Query: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIF 663
GERG +LSGG+KQR+AIARA++++P ++L DEATS+LD+ +E + A+ + RT+I
Sbjct: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 664 IAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ 714
IAHRLSTV +AD I + G + E+G+H L+ +Y ++ + Q+S Q
Sbjct: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLVNMQTSGSQ 636
Score = 198 bits (504), Expect = 1e-50
Identities = 107/242 (44%), Positives = 159/242 (65%), Gaps = 5/242 (2%)
Query: 473 VAFDNVHFEYIEGQKV--LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI 530
+ F+ V F Y V L G+S EV G+ +A+VG SG GKST+V+LL RFY+P G++
Sbjct: 987 ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV 1046
Query: 531 YLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGL 588
L GQ + ++++ LR +G+V Q+ +LF +I N+ YG+ S S +E+ + AK A +
Sbjct: 1047 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1106
Query: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
H I +PH Y+T+VG++G +LSGG+KQR+AIARA+++ P ++L DEATS+LD+ +E+ +
Sbjct: 1107 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1166
Query: 649 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHT 708
A+ + RT I IAHRLST+ +AD I+V G+V E GTH LLA IY M
Sbjct: 1167 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSV 1225
Query: 709 QS 710
Q+
Sbjct: 1226 QA 1227
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 199 bits (505), Expect = 1e-50
Identities = 164/571 (28%), Positives = 277/571 (48%), Gaps = 26/571 (4%)
Query: 150 GAKAMNIVVPFMFKYAVDSLNQMSGNMLN--LSDAPNTVATMATAVLIGYGVSRAGAAFF 207
GA +N+ +P + V+ + + + + + ++++ N ++T +LI YGV G F
Sbjct: 140 GAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQN----LSTHLLILYGVQ--GLLTF 193
Query: 208 NEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSA 267
+ + V + + + +F L D+ F + +TG L + +
Sbjct: 194 GYL--VLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKL 251
Query: 268 LVFNLLPIMFEVM--LVS-GVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMN 324
++ L +V LVS +L + + T +G T + + + + ++
Sbjct: 252 VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIA 311
Query: 325 KADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSA 384
+A A A L N TV+ F E+ E +RY L+ + + +A+ +
Sbjct: 312 RAMGVADEA----LGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNI 367
Query: 385 IFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNT 444
F+ + + + + LT GDL+ + + L ++ + + L
Sbjct: 368 AFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGAR 427
Query: 445 LFTLLKVDTQIKDKVMASPLQITPQT--ATVAFDNVHFEYI--EGQKVLSGISFEVPAGK 500
+F + ++ I ++ + + +V F NV F Y G +VL + +P GK
Sbjct: 428 VFEYMALNPCIP---LSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGK 484
Query: 501 KVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLR-RAVGVVPQDAVLF 559
VA+VG SG GK+T+ LL RFY+P G + L G++++ + LR + VG + Q+ VLF
Sbjct: 485 IVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLF 544
Query: 560 HNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVA 619
TI N+ +G + AS EEVY A+ A H+ I P GY+T VGERG LSGG+KQR+A
Sbjct: 545 GTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLA 604
Query: 620 IARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIV 679
IARA++K P V++ DEATS+LD+ +E + A+ RT + IAHRLSTV A I+V
Sbjct: 605 IARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVV 664
Query: 680 LDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
+ G+V E GTH LL +Y+E+ Q+
Sbjct: 665 MADGRVWEAGTHEELL-KKGGLYAELIRRQA 694
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 191 bits (484), Expect = 3e-48
Identities = 132/406 (32%), Positives = 208/406 (51%), Gaps = 10/406 (2%)
Query: 309 TVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETAS 368
T A+T + + + E+ A G A ++L N T+ E+ Q Y+ L+T +
Sbjct: 411 TAAMTGFANKDKQELKHA----GKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNT 466
Query: 369 LKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFL 428
K + A A + I AG +T + +V + ++ +
Sbjct: 467 SKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGET 526
Query: 429 GTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV 488
+ E +A LF LL+ I + T + + F V F Y V
Sbjct: 527 LVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCE-GNLEFREVSFFYPCRPDV 585
Query: 489 --LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLR 546
L G+S + GK VA VG SG GKST V+LL R Y+P +G + G + ++++++ LR
Sbjct: 586 FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLR 645
Query: 547 RAVGVVPQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVG 604
+ +VPQ+ VLF+ +I N+ YG+ S +E+ A A +H I +P Y+TQVG
Sbjct: 646 SQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVG 705
Query: 605 ERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFI 664
+G +LSGG+KQR+AIARA+L+ P ++L DEATS+LD+ +E+ + A+ RT + +
Sbjct: 706 LKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVV 765
Query: 665 AHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
HRLS + +AD I+VL GK+ E+GTH LL N IY ++ + QS
Sbjct: 766 THRLSAIQNADLIVVLHNGKIKEQGTHQELLRN-RDIYFKLVNAQS 810
Score = 143 bits (361), Expect = 5e-34
Identities = 81/213 (38%), Positives = 129/213 (60%), Gaps = 10/213 (4%)
Query: 536 NIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRM 595
+I+ +++ R +GVV Q+ VLF TI N+ YG + EE+ A+ A +D I+
Sbjct: 6 DIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF 65
Query: 596 PHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDV 655
P+ ++T VGE+G ++SGG+KQR+AIARA++++P +++ DEATS+LDS ++ + A++
Sbjct: 66 PNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKA 125
Query: 656 VKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQN 715
K RT+I +AHRLST+ AD I+ L G +AE+G H L+A Y S V +
Sbjct: 126 SKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYY--------SLVMS 177
Query: 716 HDNPKWEAKKENISKEEERK--KLQEEIVNSVK 746
D K + + E+++ ERK L V S+K
Sbjct: 178 QDIKKADEQMESMTYSTERKTNSLPLHSVKSIK 210
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 191 bits (484), Expect = 3e-48
Identities = 155/511 (30%), Positives = 246/511 (48%), Gaps = 24/511 (4%)
Query: 206 FFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFH--LSRQTGALSKAIDRGTRGISF 263
F ++ F K + +R+ K F + D+ + L GAL+ + +
Sbjct: 811 FTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQG 870
Query: 264 VLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEM 323
+ + ++ F + V+ ++ + + +LV L TR T F
Sbjct: 871 AAGSQI-GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRD 929
Query: 324 NKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFL-KTYETASLKSTSTLAMLNFGQ 382
+A G ++L N TV ER + + L K ++TA K+ F Q
Sbjct: 930 KQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQ 989
Query: 383 SAIFSVGLTAIM----VLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRET--- 435
+F + +++++G+ V ++ + L LG + T
Sbjct: 990 CIMFIANSASYRYGGYLISNEGL--------HFSYVFRVISAVVLSATALGRAFSYTPSY 1041
Query: 436 RQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE--GQKVLSGIS 493
+A I F LL I A Q + F + F Y +VL+G+S
Sbjct: 1042 AKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQ-GKIDFVDCKFTYPSRPDSQVLNGLS 1100
Query: 494 FEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVP 553
+ G+ +A VG SG GKST ++LL RFY+P +G + + G + + V+++ LR +G+V
Sbjct: 1101 VSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVS 1160
Query: 554 QDAVLFHNTIYYNLLYG-NISASP-EEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLS 611
Q+ VLF +I N+ YG N P E V A AK A LHD ++ +P Y+T VG +G +LS
Sbjct: 1161 QEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLS 1220
Query: 612 GGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTV 671
GEKQR+AIARAI++DP ++L DEATS+LD+ +E+T+ A+ + RT I IAHRLST+
Sbjct: 1221 RGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTI 1280
Query: 672 VDADEIIVLDQGKVAERGTHHGLLANPHSIY 702
+AD I V+ QG V E+GTH L+A + Y
Sbjct: 1281 QNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
Score = 183 bits (464), Expect = 6e-46
Identities = 126/426 (29%), Positives = 216/426 (50%), Gaps = 5/426 (1%)
Query: 325 KADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLN-FGQS 383
KA AG A + + + TV F E+ E +RY+ L + ++ + F
Sbjct: 272 KAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWC 331
Query: 384 AIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMN 443
IF A ++ + G T G LV + + +L L
Sbjct: 332 LIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAAT 391
Query: 444 TLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKK 501
++F + I D + ++ + F NV F Y K+L+ ++ + G+
Sbjct: 392 SIFETID-RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEM 450
Query: 502 VAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHN 561
A+VG SG+GKST ++L+ RFY+P +G + + G +I+ ++++ LR +G+V Q+ VLF
Sbjct: 451 TALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFST 510
Query: 562 TIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIA 621
TI N+ YG A+ E++ AK A ++ I+ +P +DT VGE G ++SGG+KQRVAIA
Sbjct: 511 TIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIA 570
Query: 622 RAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLD 681
RA++++P ++L D ATS+LD+ +E + + + T I +AHRLSTV AD II +
Sbjct: 571 RALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFE 630
Query: 682 QGKVAERGTHHGLLANPHSIYSEM-WHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEE 740
G ERGTH LL ++ + +Q ++ N ++ K + + +++ R Q+
Sbjct: 631 HGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDS 690
Query: 741 IVNSVK 746
+ S++
Sbjct: 691 LRASIR 696
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 189 bits (480), Expect = 8e-48
Identities = 173/602 (28%), Positives = 281/602 (46%), Gaps = 81/602 (13%)
Query: 122 IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSD 181
++ +LSY +PD+ VA S FL A +P+ A+D + + +M S
Sbjct: 174 LQKLLSYT----KPDVAFLVAASF-FLIVAALGETFLPYYTGRAIDGI-VIQKSMDQFST 227
Query: 182 APNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241
A V +A G++F +R +F + R+ +F L + + F
Sbjct: 228 AVVIVCLLAI-----------GSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSF 276
Query: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301
+TG L + T +S ++S N+ + + V+GV+ + F+L +
Sbjct: 277 FDENRTGDLISRLTSDTTMVSDLVSQ---NINVFLRNTVKVTGVVVF----MFSLSWQLS 329
Query: 302 LGTYTAFTVAVT------RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQ 355
L T+ F + + ++ R E+ A A N A +++ +TV+ F NE EA+
Sbjct: 330 LVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAE 389
Query: 356 RYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVN 415
Y L+ + LN ++A + V G+ +VG
Sbjct: 390 VY-----------LRKLQQVYKLNRKEAAAYMY------------YVWGSGSVG------ 420
Query: 416 GLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL-KVDTQIKDKVMASPLQITPQTATVA 474
+VY Q + +F + + T + D +A V
Sbjct: 421 --------------SVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPD----HLEGRVD 462
Query: 475 FDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL 532
F+NV F Y +VL +SF + GK A+VG SGSGKS+ V +L FY + G + L
Sbjct: 463 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL 522
Query: 533 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAI 592
G+ I + L R + +V Q+ VLF +I N+ YG + E V A+ A H I
Sbjct: 523 DGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFI 582
Query: 593 LRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM 652
+ + GY T+ GE+G +LSGG+KQRVA+ARA++++PPV++ DEATS+LD+ +E I A+
Sbjct: 583 MELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAI 642
Query: 653 KDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSR 712
++ T + IAHRLSTV A I+VLD+G+V ++GTH LLA +Y+++ Q
Sbjct: 643 HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLG 701
Query: 713 VQ 714
+Q
Sbjct: 702 LQ 703
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 186 bits (471), Expect = 9e-47
Identities = 142/520 (27%), Positives = 250/520 (48%), Gaps = 30/520 (5%)
Query: 185 TVATMATAVL--IGYGV-SRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241
++ T+A+AVL +G G+ + + ++ VFG V + +N
Sbjct: 292 SILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQN------------ 339
Query: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301
QTG + + T +S LS + L + + + G++ + +VTL T
Sbjct: 340 ----QTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWG-SVSLTMVTLIT 394
Query: 302 LGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFL 361
L V +W +++ ++ + AI++L TV+ F NE EAQ++ L
Sbjct: 395 LPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL 454
Query: 362 KTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQL 421
+ +T + K A+ ++ S + I+ + Q + +G ++ G+LV Q
Sbjct: 455 QEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQF 514
Query: 422 SLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE 481
+ + L ++Y ++A+ +F L + + +PL + V F +V F
Sbjct: 515 TQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLE---GLVQFQDVSFA 571
Query: 482 YIEGQKVL--SGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
Y VL G++F + G+ A+VG +GSGKST+ LL Y+P G + L G+ +
Sbjct: 572 YPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ 631
Query: 540 VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGLHDAILRMPH 597
L R V V Q+ +F ++ N+ YG ++ P EE+ A A +G H I +P
Sbjct: 632 YEHRYLHRQVAAVGQEPQVFGRSLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQ 690
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
GYDT+V E G +LSGG++Q VA+ARA+++ P V++ D+ATS+LD+ ++ + + + +
Sbjct: 691 GYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPE 750
Query: 658 H--RTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
R+ + I LS V AD I+ L+ G + E GTH L+
Sbjct: 751 RYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLM 790
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 163 bits (413), Expect = 5e-40
Identities = 146/479 (30%), Positives = 231/479 (48%), Gaps = 40/479 (8%)
Query: 225 RIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVML--- 281
RI + +F L DLGF +TG L+ + T L+ N LP+ V+L
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDT--------TLMSNWLPLNANVLLRSL 275
Query: 282 --VSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTR-WRTRFRI---EMNKADNDAGNAAI 335
V G+ + L L L + FT+A + + TR + E+ A AG
Sbjct: 276 VKVVGLYGFMLSISPRLTLLSLL--HMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVR 333
Query: 336 DSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMV 395
+++ +TV+ F E +E RY L+ + A+ + + +G+ +M+
Sbjct: 334 EAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRR-VLHLGVQMLML 392
Query: 396 LAS-QGIVAGTLTVGDLVMVNGLLFQLSLP--LNFLGTVYRETRQALIDMNTLFTLLKVD 452
Q + G LT G L+ +++Q S+ + L +Y + + +F+ +
Sbjct: 393 SCGLQQMQDGELTQGSLLSF--MIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMD-- 448
Query: 453 TQIKDKVMASPLQITPQT--ATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKVAIVGGS 508
+ + SP + P T V F +V F Y + VL G++F + G+ A+VG +
Sbjct: 449 ---RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPN 505
Query: 509 GSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLL 568
GSGKST+ LL Y+P G + L + I L V V Q+ VLF ++ N+
Sbjct: 506 GSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIA 565
Query: 569 YGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDP 628
YG S ++V A A+ A D I M HG T VGE+G +L+ G+KQR+AIARA+++DP
Sbjct: 566 YGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDP 625
Query: 629 PVILYDEATSSLDSITEETILGAMKDVVKH--RTSIFIAHRLSTVVDADEIIVLDQGKV 685
V++ DEATS+LD E+ A++D RT + IAHRL V A +I+VL +GK+
Sbjct: 626 RVLILDEATSALDVQCEQ----ALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 163 bits (413), Expect = 5e-40
Identities = 150/554 (27%), Positives = 253/554 (45%), Gaps = 30/554 (5%)
Query: 174 GNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLH 233
GN ++SD+ M I Y +S A +R VF K + R+ +F
Sbjct: 896 GNETSVSDSMKDNPHMQYYASI-YALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRR 954
Query: 234 LHNLDLGFHLSRQTGAL----SKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYK 289
+ + F + TG + SK +D + F + N++ + F V +++GV
Sbjct: 955 ILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVF--- 1011
Query: 290 CGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAID----SLLNYETVK 345
+ LV +G L + V+R R E+ + DN + + S+ T+
Sbjct: 1012 ---PWFLVAVGPLVILFSVLHIVSRVLIR---ELKRLDNITQSPFLSHITSSIQGLATIH 1065
Query: 346 YFNNERYEAQRYDGFLKTYETASLKSTSTLAML--NFGQSAIFSVGLTAIMVLASQGIVA 403
+N + RY L + T + L +I + T +M++ G +
Sbjct: 1066 AYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIP 1125
Query: 404 GT---LTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM 460
L + V + GL FQ ++ L T R T I+ L+ +IK+K
Sbjct: 1126 PAYAGLAISYAVQLTGL-FQFTVRLAS-ETEARFTSVERINHYIKTLSLEAPARIKNK-- 1181
Query: 461 ASPLQITPQTATVAFDNVHFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLL 519
+P PQ V F+N Y E VL +SF + +K+ IVG +GSGKS++ L
Sbjct: 1182 -APSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMAL 1240
Query: 520 FRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEV 579
FR E G I + G I D+ L LR + ++PQ+ VLF T+ NL N + +++
Sbjct: 1241 FRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQI 1299
Query: 580 YAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSS 639
+ + + + I ++P +++V E G S GE+Q + IARA+L+ +++ DEAT++
Sbjct: 1300 WDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAA 1359
Query: 640 LDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPH 699
+D+ T+ I +++ T + IAHRL TV+ +D I+VL QG+V E T LL+N
Sbjct: 1360 MDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS 1419
Query: 700 SIYSEMWHTQSSRV 713
S + M+ ++V
Sbjct: 1420 SRFYAMFAAAENKV 1433
Score = 115 bits (289), Expect = 1e-25
Identities = 80/283 (28%), Positives = 134/283 (47%), Gaps = 33/283 (11%)
Query: 477 NVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQN 536
++H ++ Q+ L I E+ GK V I G GSGK++++ + +GSI ++G
Sbjct: 566 HIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG-- 623
Query: 537 IQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMP 596
V Q A + + T+ N+L+G E +V L + +P
Sbjct: 624 -----------TFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILP 671
Query: 597 HGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDV 655
T++GERG LSGG++QR+++ARA+ D + + D+ S+LD+ + A++
Sbjct: 672 SSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH 731
Query: 656 VKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL-----------------ANP 698
+K +T +F+ H+L +VD DE+I + +G + ERGTH L+ P
Sbjct: 732 LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP 791
Query: 699 HSIYSEMWHTQSSRVQNHDNPK-WEAKKENISKEEERKKLQEE 740
I S+ + S + PK KKE K EE + +Q E
Sbjct: 792 VEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLE 834
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 152 bits (385), Expect = 8e-37
Identities = 100/327 (30%), Positives = 174/327 (53%), Gaps = 9/327 (2%)
Query: 386 FSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQA------L 439
F+V L AI + + G+L + + + LS L +G RQ+ +
Sbjct: 948 FAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMM 1007
Query: 440 IDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQK-VLSGISFEVPA 498
I + + ++ + + P P + FDNV+F Y G VL ++ + +
Sbjct: 1008 ISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKS 1067
Query: 499 GKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVL 558
+KV IVG +G+GKS+++ LFR EP+ G I++ ++ L LR+ + ++PQ+ VL
Sbjct: 1068 QEKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVL 1126
Query: 559 FHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRV 618
F T+ NL N + EE++ + L + I +P DT++ E G S G++Q V
Sbjct: 1127 FTGTMRKNLDPFN-EHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLV 1185
Query: 619 AIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEII 678
+ARAIL+ +++ DEAT+++D T+E I +++ H T + IAHRL+T++D+D+I+
Sbjct: 1186 CLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIM 1245
Query: 679 VLDQGKVAERGTHHGLLANPHSIYSEM 705
VLD G++ E + LL N S++ +M
Sbjct: 1246 VLDSGRLKEYDEPYVLLQNKESLFYKM 1272
Score = 99.0 bits (245), Expect = 1e-20
Identities = 80/335 (23%), Positives = 156/335 (46%), Gaps = 23/335 (6%)
Query: 361 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLF- 419
L+ E + + +S L +N ++ FS + V + ++ G++ V V L+
Sbjct: 302 LRKKEISKILRSSCLRGMNL--ASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYG 359
Query: 420 --QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDN 477
+L++ L F + R + +A++ + + T L +D +I + P F
Sbjct: 360 AVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLD-EISQRNRQLPSDGKKMVHVQDF-T 416
Query: 478 VHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
++ L G+SF V G+ +A+VG G+GKS+++ + P G + + G+
Sbjct: 417 AFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-- 474
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
+ V Q +F T+ N+L+G E V K L + +
Sbjct: 475 -----------IAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDLQLLED 522
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVV 656
G T +G+RG LSGG+K RV +ARA+ +D + L D+ S++D+ ++ + ++
Sbjct: 523 GDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQIL 582
Query: 657 KHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTH 691
+ +I + H+L + A +I++L GK+ ++GT+
Sbjct: 583 HEKITILVTHQLQYLKAASQILILKDGKMVQKGTY 617
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 152 bits (383), Expect = 1e-36
Identities = 137/523 (26%), Positives = 221/523 (42%), Gaps = 43/523 (8%)
Query: 197 YGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDR 256
Y S F + VF K + + VF + + F + TG L +
Sbjct: 855 YTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSK 914
Query: 257 GTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAF-------- 308
+ L N L F V+ + +L A +V +G +
Sbjct: 915 DMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQ 974
Query: 309 ------TVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNE-RYEAQRYDGFL 361
V+ + W T M +S + Y + YFN R+ A R D +
Sbjct: 975 ELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLL-YFNCALRWFALRMDVLM 1033
Query: 362 KTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQL 421
+ + L L+F + S GL+ ++ G++ + G +
Sbjct: 1034 NILTF----TVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAK--FTSV 1087
Query: 422 SLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE 481
L ++ T E L KV T KD P + F +
Sbjct: 1088 ELLREYISTCVPECTHPL----------KVGTCPKD---------WPSRGEITFRDYQMR 1128
Query: 482 YIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 540
Y + VL ++ + +G+ V IVG +GSGKS++ LFR EP G+I++ +I +
Sbjct: 1129 YRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICIL 1188
Query: 541 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 600
SLE LR + V+PQD VLF T+ YNL S + E ++ V + + D I+++P
Sbjct: 1189 SLEDLRTKLTVIPQDPVLFVGTVRYNLDPFE-SHTDEMLWQVLERTFMRDTIMKLPEKLQ 1247
Query: 601 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 660
+V E G S GE+Q + +ARA+L++ +IL DEAT+S+DS T+ + +KD K T
Sbjct: 1248 AEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCT 1307
Query: 661 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYS 703
+ IAHRL+TV++ D ++V++ GKV E L P S ++
Sbjct: 1308 VLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFA 1350
Score = 118 bits (296), Expect = 2e-26
Identities = 66/211 (31%), Positives = 115/211 (54%), Gaps = 15/211 (7%)
Query: 486 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESL 545
+ VL ISF V GK + I G GSGKS+++ L + QKG + + G
Sbjct: 493 KSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG----------- 541
Query: 546 RRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGE 605
+ V Q A +FH + N+L+G + ++ GL + +P+G T++GE
Sbjct: 542 --TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
Query: 606 RGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFI 664
RGL LSGG++QR+++ARA+ D + L D+ S++D+ + + +K ++ +T + +
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 665 AHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
H+L + DE+I+L+ G++ E+GTH L+
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELM 689
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 149 bits (376), Expect = 9e-36
Identities = 98/317 (30%), Positives = 170/317 (53%), Gaps = 6/317 (1%)
Query: 387 SVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLF 446
+V +A+M++ + ++G TVG V+ N L ++ LN+L + E ++ + +
Sbjct: 1218 TVFFSALMMVIYRDTLSGD-TVG-FVLSNAL--NITQTLNWLVRMTSEIETNIVAVERIT 1273
Query: 447 TLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYI-EGQKVLSGISFEVPAGKKVAIV 505
KV+ + P P + F+N Y E VL GI+ ++ + +K+ +V
Sbjct: 1274 EYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVV 1333
Query: 506 GGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYY 565
G +G+GKS++ LFR E G I + G +I + L LR + ++PQD +LF ++
Sbjct: 1334 GRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRM 1393
Query: 566 NLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAIL 625
NL N + S EE++ +LA L + + G +V E G LS G++Q + + RA+L
Sbjct: 1394 NLDPFN-NYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALL 1452
Query: 626 KDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKV 685
+ +++ DEAT+++D T+ I +++ H T I IAHRL T++D+D+++VLD GK+
Sbjct: 1453 RKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKI 1512
Query: 686 AERGTHHGLLANPHSIY 702
E G+ LL P Y
Sbjct: 1513 IECGSPEELLQIPGPFY 1529
Score = 101 bits (251), Expect = 3e-21
Identities = 65/253 (25%), Positives = 124/253 (49%), Gaps = 22/253 (8%)
Query: 484 EGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543
+ + + ++ ++ AG+ VA++G GSGKS+++ + E G I + G
Sbjct: 649 DSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG--------- 699
Query: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603
VPQ + + + TI N+L+G + + V + L + +P G ++
Sbjct: 700 ----TTAYVPQQSWIQNGTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEI 754
Query: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM---KDVVKHRT 660
GE+G+ LSGG+KQR+++ARA ++ + L D+ S++D+ + I + ++K +T
Sbjct: 755 GEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKT 814
Query: 661 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 720
+ + H + + DEI+VL G + E+G++ LLA + H P+
Sbjct: 815 RLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNL-----KTFLRHTGPE 869
Query: 721 WEAKKENISKEEE 733
EA + S+EE+
Sbjct: 870 EEATVHDGSEEED 882
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 149 bits (376), Expect = 9e-36
Identities = 95/280 (33%), Positives = 152/280 (54%), Gaps = 5/280 (1%)
Query: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMAS-PLQITPQTATVAFDNV 478
Q++ LN++ + + ++ + + K +T+ V S P + P V F N
Sbjct: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNY 1294
Query: 479 HFEYIEG-QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Y G VL +S V G+KV IVG +G+GKS++ LFR E KG I + G N+
Sbjct: 1295 SVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV 1354
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNL-LYGNISASPEEVYAVAKLAGLHDAILRMP 596
D+ L LR + ++PQD +LF T+ NL +G S S E+++ +L+ LH + P
Sbjct: 1355 ADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHTFVSSQP 1412
Query: 597 HGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVV 656
G D Q E G LS G++Q V +ARA+L+ +++ DEAT+++D T+ I ++
Sbjct: 1413 AGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQF 1472
Query: 657 KHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 696
T + IAHRL+T++D ++VLD+G VAE + L+A
Sbjct: 1473 DTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA 1512
Score = 118 bits (296), Expect = 2e-26
Identities = 89/318 (27%), Positives = 150/318 (47%), Gaps = 27/318 (8%)
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLL---KVDTQIKDKVMASP-LQITPQTATVAFD 476
L LPLN L + QA + + + L ++D Q ++ SP IT + T +
Sbjct: 578 LRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWA 637
Query: 477 NVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQN 536
+ L + +VP G VA+VG G GKS++V L E +G +++ G
Sbjct: 638 Q------DLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-- 689
Query: 537 IQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMP 596
+V VPQ A + + T+ N+L+G + +P+ + L + +P
Sbjct: 690 -----------SVAYVPQQAWIQNCTLQENVLFGK-ALNPKRYQQTLEACALLADLEMLP 737
Query: 597 HGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM---K 653
G T++GE+G+ LSGG++QRV++ARA+ D + L D+ S++DS + I + +
Sbjct: 738 GGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPE 797
Query: 654 DVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRV 713
V+ +T + + H +S + D IIVL G+V+E G + LL S + + +
Sbjct: 798 GVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDED 857
Query: 714 QNHDNPKWEAKKENISKE 731
Q H W A + KE
Sbjct: 858 QGHLEDSWTALEGAEDKE 875
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 145 bits (367), Expect = 1e-34
Identities = 130/438 (29%), Positives = 208/438 (47%), Gaps = 34/438 (7%)
Query: 225 RIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVML--- 281
RI + +F L DLGF +TG L+ + T L+ N LP+ V+L
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDT--------TLMSNWLPLNANVLLRSL 275
Query: 282 --VSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTR-WRTRFRI---EMNKADNDAGNAAI 335
V G+ + L L L + FT+A + + TR + E+ A AG
Sbjct: 276 VKVVGLYGFMLSISPRLTLLSLL--HMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVR 333
Query: 336 DSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMV 395
+++ +TV+ F E +E RY L+ + A+ + + +G+ +M+
Sbjct: 334 EAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRR-VLHLGVQMLML 392
Query: 396 LAS-QGIVAGTLTVGDLVMVNGLLFQLSLP--LNFLGTVYRETRQALIDMNTLFTLLKVD 452
Q + G LT G L+ +++Q S+ + L +Y + + +F+ +
Sbjct: 393 SCGLQQMQDGELTQGSLLSF--MIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMD-- 448
Query: 453 TQIKDKVMASPLQITPQT--ATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKVAIVGGS 508
+ + SP + P T V F +V F Y + VL G++F + G+ A+VG +
Sbjct: 449 ---RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPN 505
Query: 509 GSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLL 568
GSGKST+ LL Y+P G + L + I L V V Q+ VLF ++ N+
Sbjct: 506 GSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIA 565
Query: 569 YGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDP 628
YG S ++V A A+ A D I M HG T VGE+G +L+ G+KQR+AIARA+++DP
Sbjct: 566 YGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDP 625
Query: 629 PVILYDEATSSLDSITEE 646
V++ DEATS+LD E+
Sbjct: 626 RVLILDEATSALDVQCEQ 643
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 143 bits (361), Expect = 5e-34
Identities = 87/248 (35%), Positives = 138/248 (55%), Gaps = 2/248 (0%)
Query: 468 PQTATVAFDNVHFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQ 526
PQ + F + H +Y + VL GI+ + + V IVG +GSGKS++ LFR EP
Sbjct: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
Query: 527 KGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLA 586
G I + G +I + LE LR + V+PQD VL TI +NL + + ++++ +
Sbjct: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFD-RHTDQQIWDALERT 1254
Query: 587 GLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEE 646
L AI + P T V E G S GE+Q + IARA+L++ +IL DEAT+S+D T+
Sbjct: 1255 FLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDT 1314
Query: 647 TILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMW 706
I +++ + T + IAHR++TV++ D I+V+ GKV E L P S+++ +
Sbjct: 1315 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1374
Query: 707 HTQSSRVQ 714
T +S ++
Sbjct: 1375 ATATSSLR 1382
Score = 99.0 bits (245), Expect = 1e-20
Identities = 67/256 (26%), Positives = 124/256 (48%), Gaps = 18/256 (7%)
Query: 489 LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRA 548
L I+ V G + + G +GSGKS+++ + +GS+ + G +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 549 VGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGL 608
+ VPQ A + I N+L G + V L+ + +P G T++GERGL
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGG-AYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 609 KLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFIAHR 667
LSGG+KQR+++ARA+ D + L D+ S++D+ + + +K ++ +T + + H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 668 LSTVVDADEIIVLDQGKVAERGTHHGLL--ANPHSIYSEMWHTQSSRVQNHDNPKWEAKK 725
L + +II+L+ GK+ E GTH L+ ++ + H +++ D K A+K
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK-IAEK 751
Query: 726 ENISKEEERKKLQEEI 741
+ + L+E +
Sbjct: 752 PKVESQALATSLEESL 767
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 143 bits (361), Expect = 5e-34
Identities = 87/248 (35%), Positives = 138/248 (55%), Gaps = 2/248 (0%)
Query: 468 PQTATVAFDNVHFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQ 526
PQ + F + H +Y + VL GI+ + + V IVG +GSGKS++ LFR EP
Sbjct: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
Query: 527 KGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLA 586
G I + G +I + LE LR + V+PQD VL TI +NL + + ++++ +
Sbjct: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFD-RHTDQQIWDALERT 1254
Query: 587 GLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEE 646
L AI + P T V E G S GE+Q + IARA+L++ +IL DEAT+S+D T+
Sbjct: 1255 FLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDT 1314
Query: 647 TILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMW 706
I +++ + T + IAHR++TV++ D I+V+ GKV E L P S+++ +
Sbjct: 1315 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1374
Query: 707 HTQSSRVQ 714
T +S ++
Sbjct: 1375 ATATSSLR 1382
Score = 99.0 bits (245), Expect = 1e-20
Identities = 67/256 (26%), Positives = 124/256 (48%), Gaps = 18/256 (7%)
Query: 489 LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRA 548
L I+ V G + + G +GSGKS+++ + +GS+ + G +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 549 VGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGL 608
+ VPQ A + I N+L G + V L+ + +P G T++GERGL
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGG-AYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 609 KLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFIAHR 667
LSGG+KQR+++ARA+ D + L D+ S++D+ + + +K ++ +T + + H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 668 LSTVVDADEIIVLDQGKVAERGTHHGLL--ANPHSIYSEMWHTQSSRVQNHDNPKWEAKK 725
L + +II+L+ GK+ E GTH L+ ++ + H +++ D K A+K
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK-IAEK 751
Query: 726 ENISKEEERKKLQEEI 741
+ + L+E +
Sbjct: 752 PKVESQALATSLEESL 767
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 142 bits (359), Expect = 9e-34
Identities = 94/286 (32%), Positives = 152/286 (53%), Gaps = 3/286 (1%)
Query: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM-ASPLQITPQTATVAFDNV 478
Q++ LN+L + E ++ + L + + + ++ +P PQ V F N
Sbjct: 1183 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNY 1242
Query: 479 HFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Y E VL I+ + G+KV IVG +G+GKS++ LFR E +G I + G NI
Sbjct: 1243 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1302
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
+ L LR + ++PQD VLF ++ NL + S EEV+ +LA L D + +P
Sbjct: 1303 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPD 1361
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
D + E G LS G++Q V +ARA+L+ +++ DEAT+++D T++ I ++ +
Sbjct: 1362 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1421
Query: 658 HRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYS 703
T + IAHRL+T++D +IVLD+G++ E G LL YS
Sbjct: 1422 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/348 (23%), Positives = 136/348 (39%), Gaps = 86/348 (24%)
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
L PLN L V QA + + L L + D + P++ T ++ N F
Sbjct: 592 LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 481 EYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
+ L+GI+F +P G VA+VG G GKS+++ L + +G + + G
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
Query: 540 VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVY--AVAKLAGLHDAILRMPH 597
+V VPQ A + ++++ N+L+G EE Y +V + L + +P
Sbjct: 707 --------SVAYVPQQAWIQNDSLRENILFG---CQLEEPYYRSVIQACALLPDLEILPS 755
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
G T++GE+
Sbjct: 756 GDRTEIGEK--------------------------------------------------- 764
Query: 658 HRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHD 717
T I + H +S + D IIV+ GK++E G++ LLA ++E T +S Q D
Sbjct: 765 --TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLRTYASTEQEQD 821
Query: 718 ----------NPKWEAKK-EN--ISKEEERKKLQEEIVNSVKGCGNCS 752
P EAK+ EN + + K+LQ ++ +S G+ S
Sbjct: 822 AEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDIS 869
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 142 bits (359), Expect = 9e-34
Identities = 94/286 (32%), Positives = 152/286 (53%), Gaps = 3/286 (1%)
Query: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM-ASPLQITPQTATVAFDNV 478
Q++ LN+L + E ++ + L + + + ++ +P PQ V F N
Sbjct: 1124 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNY 1183
Query: 479 HFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Y E VL I+ + G+KV IVG +G+GKS++ LFR E +G I + G NI
Sbjct: 1184 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1243
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
+ L LR + ++PQD VLF ++ NL + S EEV+ +LA L D + +P
Sbjct: 1244 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPD 1302
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
D + E G LS G++Q V +ARA+L+ +++ DEAT+++D T++ I ++ +
Sbjct: 1303 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1362
Query: 658 HRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYS 703
T + IAHRL+T++D +IVLD+G++ E G LL YS
Sbjct: 1363 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1408
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
L PLN L V QA + + L L + D + P++ T ++ N F
Sbjct: 592 LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 481 EYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI 530
+ L+GI+F +P G VA+VG G GKS+++ L + +G +
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHV 702
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 17/121 (14%)
Query: 648 ILGAMKDVVKH---RTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSE 704
+L M V H +T I + H +S + D IIV+ GK++E G++ LLA ++E
Sbjct: 691 LLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAE 749
Query: 705 MWHTQSSRVQNHD----------NPKWEAKK-EN--ISKEEERKKLQEEIVNSVKGCGNC 751
T +S Q D P EAK+ EN + + K+LQ ++ +S G+
Sbjct: 750 FLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDI 809
Query: 752 S 752
S
Sbjct: 810 S 810
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 142 bits (359), Expect = 9e-34
Identities = 94/286 (32%), Positives = 152/286 (53%), Gaps = 3/286 (1%)
Query: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM-ASPLQITPQTATVAFDNV 478
Q++ LN+L + E ++ + L + + + ++ +P PQ V F N
Sbjct: 1180 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNY 1239
Query: 479 HFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Y E VL I+ + G+KV IVG +G+GKS++ LFR E +G I + G NI
Sbjct: 1240 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1299
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
+ L LR + ++PQD VLF ++ NL + S EEV+ +LA L D + +P
Sbjct: 1300 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPD 1358
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
D + E G LS G++Q V +ARA+L+ +++ DEAT+++D T++ I ++ +
Sbjct: 1359 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1418
Query: 658 HRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYS 703
T + IAHRL+T++D +IVLD+G++ E G LL YS
Sbjct: 1419 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1464
Score = 76.6 bits (187), Expect = 8e-14
Identities = 56/184 (30%), Positives = 97/184 (52%), Gaps = 19/184 (10%)
Query: 586 AGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITE 645
+ L A+L + V +G+ LSGG+KQRV++ARA+ + + L+D+ S++D+
Sbjct: 685 SSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVG 744
Query: 646 ----ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSI 701
E ++G K ++K++T I + H +S + D IIV+ GK++E G++ LLA
Sbjct: 745 KHIFENVIGP-KGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGA 802
Query: 702 YSEMWHTQSSRVQNHD----------NPKWEAKK-EN--ISKEEERKKLQEEIVNSVKGC 748
++E T +S Q D P EAK+ EN + + K+LQ ++ +S
Sbjct: 803 FAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYS 862
Query: 749 GNCS 752
G+ S
Sbjct: 863 GDIS 866
Score = 53.1 bits (126), Expect = 9e-07
Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 3/132 (2%)
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
L PLN L V QA + + L L + D + P++ T ++ N F
Sbjct: 592 LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 481 EYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
+ L+GI+F +P G VA+VG G GKS+++ L + +G + + G N+
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSG 711
Query: 540 VSLE--SLRRAV 549
+ SL RAV
Sbjct: 712 GQKQRVSLARAV 723
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 142 bits (359), Expect = 9e-34
Identities = 94/286 (32%), Positives = 152/286 (53%), Gaps = 3/286 (1%)
Query: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM-ASPLQITPQTATVAFDNV 478
Q++ LN+L + E ++ + L + + + ++ +P PQ V F N
Sbjct: 1239 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNY 1298
Query: 479 HFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Y E VL I+ + G+KV IVG +G+GKS++ LFR E +G I + G NI
Sbjct: 1299 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1358
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
+ L LR + ++PQD VLF ++ NL + S EEV+ +LA L D + +P
Sbjct: 1359 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPD 1417
Query: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
D + E G LS G++Q V +ARA+L+ +++ DEAT+++D T++ I ++ +
Sbjct: 1418 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1477
Query: 658 HRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYS 703
T + IAHRL+T++D +IVLD+G++ E G LL YS
Sbjct: 1478 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1523
Score = 132 bits (331), Expect = 2e-30
Identities = 101/350 (28%), Positives = 172/350 (49%), Gaps = 34/350 (9%)
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
L PLN L V QA + + L L + D + P++ T ++ N F
Sbjct: 592 LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 481 EYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
+ L+GI+F +P G VA+VG G GKS+++ L + +G + + G
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
Query: 540 VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGY 599
+V VPQ A + ++++ N+L+G P + A L D + +P G
Sbjct: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI-LPSGD 757
Query: 600 DTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITE----ETILGAMKDV 655
T++GE+G+ LSGG+KQRV++ARA+ + + L+D+ S++D+ E ++G K +
Sbjct: 758 RTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP-KGM 816
Query: 656 VKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQN 715
+K++T I + H +S + D IIV+ GK++E G++ LLA ++E T +S Q
Sbjct: 817 LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLRTYASTEQE 875
Query: 716 HD----------NPKWEAKK-EN--ISKEEERKKLQEEIVNSVKGCGNCS 752
D P EAK+ EN + + K+LQ ++ +S G+ S
Sbjct: 876 QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDIS 925
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 138 bits (348), Expect = 2e-32
Identities = 93/303 (30%), Positives = 158/303 (52%), Gaps = 11/303 (3%)
Query: 417 LLFQLSLP--LNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTAT-- 472
L + LSL L+ L + + +T L+ + L + + + PLQ+ T
Sbjct: 1160 LSYALSLTGLLSGLVSSFTQTEAMLVSVERLE---EYTCDLPQEPQGQPLQLGTGWLTQG 1216
Query: 473 -VAFDNVHFEYIEG-QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI 530
V F +V Y G L G++F V G+K+ IVG +GSGKS+++ +LFR EP G +
Sbjct: 1217 GVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRV 1276
Query: 531 YLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHD 590
L G + + L LR + ++PQ+ LF T+ NL + ++ K L +
Sbjct: 1277 LLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKD-RALWQALKQCHLSE 1335
Query: 591 AILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILG 650
I M G D ++GE G LS G++Q + +ARA+L D ++ DEAT+S+D T++ +
Sbjct: 1336 VITSMG-GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQ 1394
Query: 651 AMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
+ ++T + IAHRL+T++++D ++VL G+V E + L PHS++ ++ +
Sbjct: 1395 TICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQ 1454
Query: 711 SRV 713
V
Sbjct: 1455 QGV 1457
Score = 87.4 bits (215), Expect = 4e-17
Identities = 65/253 (25%), Positives = 124/253 (49%), Gaps = 20/253 (7%)
Query: 495 EVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQ 554
EV G V IVG G GKS+++ + +G + + G L + G+ Q
Sbjct: 594 EVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQ 643
Query: 555 DAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGE 614
+ + TI N+L+G + + V + L+D + +P G T+VGE+G+ LSGG+
Sbjct: 644 EPWIQFATIRDNILFGK-TFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQ 702
Query: 615 KQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFIAHRLSTVVD 673
+ R+A+ARA+ ++ + L D+ +++D+ + + + ++ + T + HR +
Sbjct: 703 RARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLER 762
Query: 674 ADEIIVLDQGKVAERGTHHGLL----ANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENIS 729
AD +++++ G++ G +L A P + + S+ Q+ NP E KE +
Sbjct: 763 ADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNP--EKTKEGLE 820
Query: 730 KEEER--KKLQEE 740
+E+ + LQEE
Sbjct: 821 EEQSTSGRLLQEE 833
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 132 bits (332), Expect = 1e-30
Identities = 79/236 (33%), Positives = 129/236 (54%), Gaps = 2/236 (0%)
Query: 468 PQTATVAFDNVHFEYI-EGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQ 526
PQ + F + Y E + G+SF++ AG+KV IVG +G+GKS++ L R E
Sbjct: 1069 PQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAA 1128
Query: 527 KGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLA 586
+G I++ G I V L +LR + ++PQD +LF ++ NL S E ++A +
Sbjct: 1129 EGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQ-EHSDEAIWAALETV 1187
Query: 587 GLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEE 646
L + +P + +RG LS G+KQ + +ARA+L+ +++ DEAT+++D TE
Sbjct: 1188 QLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTEL 1247
Query: 647 TILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIY 702
+ + T + IAHRL +V+D ++V+D+G+VAE G+ LLA Y
Sbjct: 1248 QMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303
Score = 108 bits (271), Expect = 1e-23
Identities = 110/441 (24%), Positives = 191/441 (43%), Gaps = 33/441 (7%)
Query: 266 SALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNK 325
S L N L + ++V V ++ AL + + +++ R + E +
Sbjct: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Query: 326 ADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAI 385
+ L N +T+K+ E R G ++ E +L+++ L ++ +
Sbjct: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLG-IRGQELGALRTSGLLFSVSLVSFQV 350
Query: 386 FSVGLTAIMVLASQGIVAGTLTVGDLVMVN-GLLFQLSLPLNFLGTVYRETRQALIDMNT 444
S L A++V A +VA + V +L L+ FL QA + +
Sbjct: 351 -STFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 409
Query: 445 LFTLL---KVDTQIKDKVMASPLQ----ITPQTATVAFDNVHFEYIEGQKVLSGISFEVP 497
L T L +VD D + IT Q+AT A+ E L I+ VP
Sbjct: 410 LVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQ------ESPPCLHRINLTVP 463
Query: 498 AGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAV 557
G +A+VG G+GKS+++ L +G + + G AV VPQ+A
Sbjct: 464 QGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAW 510
Query: 558 LFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQR 617
+ + ++ N+ +G P + V + L + P G T +GE+G+ LSGG+KQR
Sbjct: 511 VQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQR 569
Query: 618 VAIARAILKDPPVILYDEATSSLDSITEETILGAM---KDVVKHRTSIFIAHRLSTVVDA 674
+++ARA+ + V L D+ ++LD+ + + + +++ T I + H L + A
Sbjct: 570 LSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQA 629
Query: 675 DEIIVLDQGKVAERGTHHGLL 695
D IIVL G +AE G++ LL
Sbjct: 630 DWIIVLANGAIAEMGSYQELL 650
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 132 bits (331), Expect = 2e-30
Identities = 101/350 (28%), Positives = 172/350 (49%), Gaps = 34/350 (9%)
Query: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 480
L PLN L V QA + + L L + D + P++ T ++ N F
Sbjct: 592 LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 481 EYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
+ L+GI+F +P G VA+VG G GKS+++ L + +G + + G
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
Query: 540 VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGY 599
+V VPQ A + ++++ N+L+G P + A L D + +P G
Sbjct: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI-LPSGD 757
Query: 600 DTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITE----ETILGAMKDV 655
T++GE+G+ LSGG+KQRV++ARA+ + + L+D+ S++D+ E ++G K +
Sbjct: 758 RTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP-KGM 816
Query: 656 VKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQN 715
+K++T I + H +S + D IIV+ GK++E G++ LLA ++E T +S Q
Sbjct: 817 LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLRTYASTEQE 875
Query: 716 HD----------NPKWEAKK-EN--ISKEEERKKLQEEIVNSVKGCGNCS 752
D P EAK+ EN + + K+LQ ++ +S G+ S
Sbjct: 876 QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDIS 925
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/203 (31%), Positives = 98/203 (48%), Gaps = 9/203 (4%)
Query: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVM-ASPLQITPQTATVAFDNV 478
Q++ LN+L + E ++ + L + + + ++ +P PQ V F N
Sbjct: 1239 QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNY 1298
Query: 479 HFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Y E VL I+ + G+KV IVG +G+GKS++ LFR E +G I + G NI
Sbjct: 1299 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1358
Query: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
+ L LR + ++PQD VLF ++ NL + S EEV+ +LA L D + +P
Sbjct: 1359 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPD 1417
Query: 598 GYDTQVGERGLKLSGGEKQRVAI 620
D + E GGE RV +
Sbjct: 1418 KLDHECAE------GGENLRVIV 1434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,556,743
Number of Sequences: 37866
Number of extensions: 989845
Number of successful extensions: 3489
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3207
Number of HSP's gapped (non-prelim): 165
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.