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Search of human proteins with 42476333
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
(649 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 1347 0.0
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 416 e-116
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 380 e-105
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 380 e-105
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 380 e-105
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 301 9e-82
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 301 9e-82
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 119 9e-27
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 118 2e-26
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 117 3e-26
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 107 3e-23
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 107 3e-23
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 107 3e-23
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 101 2e-21
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 97 6e-20
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 96 8e-20
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 93 9e-19
gi|169210192 PREDICTED: hypothetical protein [Homo sapiens] 32 2.4
gi|33356148 formin-like 1 [Homo sapiens] 32 2.4
gi|239753568 PREDICTED: hypothetical protein [Homo sapiens] 31 4.1
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 30 5.3
gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo s... 30 5.3
gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo sa... 30 5.3
gi|239758021 PREDICTED: hypothetical protein [Homo sapiens] 30 6.9
gi|239741335 PREDICTED: hypothetical protein XP_002342177 [Homo ... 30 6.9
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 30 6.9
gi|32307177 forkhead box G1 [Homo sapiens] 30 6.9
gi|122937440 multiple EGF-like-domains 9 [Homo sapiens] 30 6.9
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 30 9.1
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 30 9.1
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 1347 bits (3487), Expect = 0.0
Identities = 649/649 (100%), Positives = 649/649 (100%)
Query: 1 MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT 60
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT
Sbjct: 1 MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT 60
Query: 61 LTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQE 120
LTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQE
Sbjct: 61 LTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQE 120
Query: 121 TREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR 180
TREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR
Sbjct: 121 TREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR 180
Query: 181 KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ 240
KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ
Sbjct: 181 KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ 240
Query: 241 VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG 300
VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG
Sbjct: 241 VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG 300
Query: 301 GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT 360
GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT
Sbjct: 301 GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT 360
Query: 361 ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA 420
ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA
Sbjct: 361 ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA 420
Query: 421 NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWL 480
NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWL
Sbjct: 421 NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWL 480
Query: 481 LPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMS 540
LPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMS
Sbjct: 481 LPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMS 540
Query: 541 CSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDD 600
CSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDD
Sbjct: 541 CSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDD 600
Query: 601 DLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL 649
DLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL
Sbjct: 601 DLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL 649
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 416 bits (1068), Expect = e-116
Identities = 228/623 (36%), Positives = 340/623 (54%), Gaps = 30/623 (4%)
Query: 24 TIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSF--YTV 81
T KEL+ WYC NTNTHG +RI+ G ++ +W TL AL+ WQ + + ++ + V
Sbjct: 21 TYKELLVWYCDNTNTHGPKRIICE-GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEV 79
Query: 82 SVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAE 141
SVS+ V F+ +DFPAVTICN +P+KYS ++HLL DL++ L+ + PE
Sbjct: 80 SVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILA-PELSHANATR 138
Query: 142 SWNSVSEGKQPRFS--HRIPLLIFDQ--DEKGKARDFFTGRKRKVGGSIIHKASNVMHIE 197
+ N FS + PL++ D+ D F + S AS +
Sbjct: 139 NLN---------FSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSS---SASEKICNA 186
Query: 198 SKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELL 257
+ +LCS + + C F+S A+ EWY L NI AQVP ++ + MSY E+++
Sbjct: 187 HGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMI 246
Query: 258 VTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEY 317
+ C F C+ RNFT +P +GNCY FN E L ++ G+E+GL++IL I +E+Y
Sbjct: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306
Query: 318 NPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGS 377
PFL S+ G ++++H Q YPF+ D G + TSIG+ + + ++ EPYS CT +GS
Sbjct: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366
Query: 378 DVPIRNI---YNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYC 434
+VP++N YN YS+Q CL SCFQ M+ C C Y PLP YCN + P+W +C
Sbjct: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426
Query: 435 YYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNK 494
Y L + Q E C +CKE+C+ ++ +T S+A WPS SE W+ VL+ ++ + N
Sbjct: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485
Query: 495 KLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIE----II 550
L++ + KL I++++ N R+I ES AN+I LLSN GGQ G WM SV+C+IE II
Sbjct: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
Query: 551 EVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALH 610
+ +I ++A + + + A PP P + N D P +
Sbjct: 546 DFVWITIIKLVALAKSLRQRRAQASYAGPP-PTVAELVEAHTNFGFQ-PDTAPRSPNTGP 603
Query: 611 LPPALGTQVPGTPPPKYNTLRLE 633
P +PGTPPP Y++LRL+
Sbjct: 604 YPSEQALPIPGTPPPNYDSLRLQ 626
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 380 bits (977), Expect = e-105
Identities = 211/611 (34%), Positives = 331/611 (54%), Gaps = 24/611 (3%)
Query: 26 KELMRWYCLNTNTHGCRRIVVSR-GRLRRLLWIGFTLTAVALILWQCALLVFSF--YTVS 82
+EL ++C NT HG R+V S+ R++ W L ++ WQ LL + Y VS
Sbjct: 115 RELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVS 174
Query: 83 VSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAES 142
++I ++ KL FPAVTIC +NPY+Y ++ L +L++ T + L LY + S
Sbjct: 175 LNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKY---------SS 225
Query: 143 WNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVV 202
+ ++ G + R R L Q + R R V S+ V + K +
Sbjct: 226 FTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWK--I 283
Query: 203 GFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFF 262
GFQLC+ + SDC T+SSG++A++EWY+ HY+NI++++P + + C F
Sbjct: 284 GFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRF 343
Query: 263 DGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLV 322
+ VSC+ N++ FHHPM+GNCYTFN++ N + +SM G GL ++L + ++ P L
Sbjct: 344 NQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLS 403
Query: 323 SSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIR 382
+ TGA+V++H QDE F++D G + + TSI M +L Y CT++GSDVP+
Sbjct: 404 TVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVE 463
Query: 383 NIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAF 442
N+Y + Y+ Q+C+HSCFQ M+++CGCA P P YC+Y++H +W YCYY+L F
Sbjct: 464 NLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDF 523
Query: 443 VQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLA 502
+ LGC + C++ CS + L+ ++WPSV S++W+ +L+ VN K N +A
Sbjct: 524 SSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN--GVA 581
Query: 503 KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF----IDFF 558
K+ IF+K+LN ++ ESP+ ++ LLSN G Q LW SV+ V+E+ E+ F I F
Sbjct: 582 KVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFL 641
Query: 559 SIIAR---RQWQKAKEW-WAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPA 614
++ R R W + A + A +P S +L + P + AL PP
Sbjct: 642 MLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPP 701
Query: 615 LGTQVPGTPPP 625
+ P P
Sbjct: 702 AYATLGPRPSP 712
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 380 bits (977), Expect = e-105
Identities = 211/611 (34%), Positives = 331/611 (54%), Gaps = 24/611 (3%)
Query: 26 KELMRWYCLNTNTHGCRRIVVSR-GRLRRLLWIGFTLTAVALILWQCALLVFSF--YTVS 82
+EL ++C NT HG R+V S+ R++ W L ++ WQ LL + Y VS
Sbjct: 79 RELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVS 138
Query: 83 VSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAES 142
++I ++ KL FPAVTIC +NPY+Y ++ L +L++ T + L LY + S
Sbjct: 139 LNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKY---------SS 189
Query: 143 WNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVV 202
+ ++ G + R R L Q + R R V S+ V + K +
Sbjct: 190 FTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWK--I 247
Query: 203 GFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFF 262
GFQLC+ + SDC T+SSG++A++EWY+ HY+NI++++P + + C F
Sbjct: 248 GFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRF 307
Query: 263 DGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLV 322
+ VSC+ N++ FHHPM+GNCYTFN++ N + +SM G GL ++L + ++ P L
Sbjct: 308 NQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLS 367
Query: 323 SSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIR 382
+ TGA+V++H QDE F++D G + + TSI M +L Y CT++GSDVP+
Sbjct: 368 TVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVE 427
Query: 383 NIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAF 442
N+Y + Y+ Q+C+HSCFQ M+++CGCA P P YC+Y++H +W YCYY+L F
Sbjct: 428 NLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDF 487
Query: 443 VQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLA 502
+ LGC + C++ CS + L+ ++WPSV S++W+ +L+ VN K N +A
Sbjct: 488 SSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN--GVA 545
Query: 503 KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF----IDFF 558
K+ IF+K+LN ++ ESP+ ++ LLSN G Q LW SV+ V+E+ E+ F I F
Sbjct: 546 KVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFL 605
Query: 559 SIIAR---RQWQKAKEW-WAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPA 614
++ R R W + A + A +P S +L + P + AL PP
Sbjct: 606 MLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPP 665
Query: 615 LGTQVPGTPPP 625
+ P P
Sbjct: 666 AYATLGPRPSP 676
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 380 bits (977), Expect = e-105
Identities = 211/611 (34%), Positives = 331/611 (54%), Gaps = 24/611 (3%)
Query: 26 KELMRWYCLNTNTHGCRRIVVSR-GRLRRLLWIGFTLTAVALILWQCALLVFSF--YTVS 82
+EL ++C NT HG R+V S+ R++ W L ++ WQ LL + Y VS
Sbjct: 56 RELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVS 115
Query: 83 VSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAES 142
++I ++ KL FPAVTIC +NPY+Y ++ L +L++ T + L LY + S
Sbjct: 116 LNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKY---------SS 166
Query: 143 WNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVV 202
+ ++ G + R R L Q + R R V S+ V + K +
Sbjct: 167 FTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWK--I 224
Query: 203 GFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFF 262
GFQLC+ + SDC T+SSG++A++EWY+ HY+NI++++P + + C F
Sbjct: 225 GFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRF 284
Query: 263 DGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLV 322
+ VSC+ N++ FHHPM+GNCYTFN++ N + +SM G GL ++L + ++ P L
Sbjct: 285 NQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLS 344
Query: 323 SSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIR 382
+ TGA+V++H QDE F++D G + + TSI M +L Y CT++GSDVP+
Sbjct: 345 TVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVE 404
Query: 383 NIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAF 442
N+Y + Y+ Q+C+HSCFQ M+++CGCA P P YC+Y++H +W YCYY+L F
Sbjct: 405 NLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDF 464
Query: 443 VQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLA 502
+ LGC + C++ CS + L+ ++WPSV S++W+ +L+ VN K N +A
Sbjct: 465 SSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN--GVA 522
Query: 503 KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF----IDFF 558
K+ IF+K+LN ++ ESP+ ++ LLSN G Q LW SV+ V+E+ E+ F I F
Sbjct: 523 KVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFL 582
Query: 559 SIIAR---RQWQKAKEW-WAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPA 614
++ R R W + A + A +P S +L + P + AL PP
Sbjct: 583 MLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPP 642
Query: 615 LGTQVPGTPPP 625
+ P P
Sbjct: 643 AYATLGPRPSP 653
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 301 bits (772), Expect = 9e-82
Identities = 181/599 (30%), Positives = 290/599 (48%), Gaps = 53/599 (8%)
Query: 24 TIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCALLVFSFY--T 80
+ +EL+ ++C N HG R+V SRG RL+ W +L A+ + WQ LL +
Sbjct: 55 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 114
Query: 81 VSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREA 140
V +++ VH + P VT+C+ NP + S V L L++ RE + SLY S+ R
Sbjct: 115 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGR--- 171
Query: 141 ESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQ 200
+ PR H P F R+ ++ + H S+
Sbjct: 172 ----AALSATVPR--HEPP--------------FHLDREIRL--------QRLSHSGSRV 203
Query: 201 VVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTC 260
VGF+LC++ DC ++SG+ A+Q+WY HY++I+A +P + + +++C
Sbjct: 204 RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSC 263
Query: 261 FFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPF 320
+DG+ C AR F FHHP +G+CYT + + + G +G+ ++L + ++ + P
Sbjct: 264 SYDGLDCQARQFRTFHHPTYGSCYTVDG-----VWTAQRPGITHGVGLVLRVEQQPHLPL 318
Query: 321 LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVP 380
L + G +V++H ++ PF+ + +I + E +L PY CT G V
Sbjct: 319 LSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVE 378
Query: 381 IRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHR 440
+ ++N +Y+ Q CL SCFQ MVE C C Y PLP A YC+ +HP W +C+Y+L++
Sbjct: 379 VELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQ 438
Query: 441 AFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD 500
L C S C C + L+T ++WPS S W L L +QG ++
Sbjct: 439 DLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATL-GEQGLPHQSHRQRSS 497
Query: 501 LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSI 560
LAK+ I Y++LN RS+ E+P S+ LLS G LW SV+ ++E++E+
Sbjct: 498 LAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALT 557
Query: 561 IARRQWQKAKEWWAWKQAPPC-------PEAPRSPQGQDNPALDIDDDLPTFNSALHLP 612
+ + + W++W +A P PEA + P PA DD S HLP
Sbjct: 558 LVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP----PAGGTSDDPEP--SGPHLP 610
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 301 bits (772), Expect = 9e-82
Identities = 181/599 (30%), Positives = 290/599 (48%), Gaps = 53/599 (8%)
Query: 24 TIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCALLVFSFY--T 80
+ +EL+ ++C N HG R+V SRG RL+ W +L A+ + WQ LL +
Sbjct: 121 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 180
Query: 81 VSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREA 140
V +++ VH + P VT+C+ NP + S V L L++ RE + SLY S+ R
Sbjct: 181 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGR--- 237
Query: 141 ESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQ 200
+ PR H P F R+ ++ + H S+
Sbjct: 238 ----AALSATVPR--HEPP--------------FHLDREIRL--------QRLSHSGSRV 269
Query: 201 VVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTC 260
VGF+LC++ DC ++SG+ A+Q+WY HY++I+A +P + + +++C
Sbjct: 270 RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSC 329
Query: 261 FFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPF 320
+DG+ C AR F FHHP +G+CYT + + + G +G+ ++L + ++ + P
Sbjct: 330 SYDGLDCQARQFRTFHHPTYGSCYTVDG-----VWTAQRPGITHGVGLVLRVEQQPHLPL 384
Query: 321 LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVP 380
L + G +V++H ++ PF+ + +I + E +L PY CT G V
Sbjct: 385 LSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVE 444
Query: 381 IRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHR 440
+ ++N +Y+ Q CL SCFQ MVE C C Y PLP A YC+ +HP W +C+Y+L++
Sbjct: 445 VELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQ 504
Query: 441 AFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD 500
L C S C C + L+T ++WPS S W L L +QG ++
Sbjct: 505 DLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATL-GEQGLPHQSHRQRSS 563
Query: 501 LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSI 560
LAK+ I Y++LN RS+ E+P S+ LLS G LW SV+ ++E++E+
Sbjct: 564 LAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALT 623
Query: 561 IARRQWQKAKEWWAWKQAPPC-------PEAPRSPQGQDNPALDIDDDLPTFNSALHLP 612
+ + + W++W +A P PEA + P PA DD S HLP
Sbjct: 624 LVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP----PAGGTSDDPEP--SGPHLP 676
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 119 bits (298), Expect = 9e-27
Identities = 83/321 (25%), Positives = 147/321 (45%), Gaps = 40/321 (12%)
Query: 249 MSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNREN-ETILSTSMGGSEYGLQ 307
+ + E++L++C + G C NF+ +G CY FN+ E+ + +L+T GG+ GL+
Sbjct: 211 LGHQLEDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLE 269
Query: 308 VILYINEEEYNPF------LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTE 361
++L I ++EY P G KV IH Q E PF++++G + T +
Sbjct: 270 IMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQR 329
Query: 362 SFKLSEPYSQC--TEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPA 419
L P+ +C +E G D + YS+ C C +VE C C +P
Sbjct: 330 LTYLPPPWGECRSSEMGLD------FFPVYSITACRIDCETRYIVENCNCRMVH--MPGD 381
Query: 420 ANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKW 479
A +C +QH + + E+ +C+ C+ + S+ + PS S K+
Sbjct: 382 APFCTPEQHKECA----EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKY 437
Query: 480 LLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGG 533
L KK NK++ + L IF++ LN +I + A + LL + GG
Sbjct: 438 L------------EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485
Query: 534 QLGLWMSCSVVCVIEIIEVFF 554
Q+GL++ S++ ++E+ + +
Sbjct: 486 QMGLFIGASILTILELFDYIY 506
Score = 38.5 bits (88), Expect = 0.020
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 10/96 (10%)
Query: 21 QAPTIKELMRWYCLNTNTHGCRRIVVSRGRL-----RRLLWIGFTLTAVALIL-WQCALL 74
Q P + R HG R + R RR LW+ T+ L+L W L
Sbjct: 49 QGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRL 108
Query: 75 VFSFYTVSVSIKVH---FRKLDFPAVTICNINPYKY 107
++ + + +VH R+L FPAVT+CN NP ++
Sbjct: 109 LY-WLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 118 bits (295), Expect = 2e-26
Identities = 84/327 (25%), Positives = 149/327 (45%), Gaps = 40/327 (12%)
Query: 243 LEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNREN-ETILSTSMGG 301
LE + + +++++ C F G C ++FT +G CY FN+ E+ + +L+T GG
Sbjct: 154 LEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGG 212
Query: 302 SEYGLQVILYINEEEYNPF------LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSI 355
+ GL+++L I ++EY P G KV IH Q E PF++++G + T +
Sbjct: 213 TGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFV 272
Query: 356 GMHLTESFKLSEPYSQC--TEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYS 413
L P+ +C +E G D + YS+ C C +VE C C
Sbjct: 273 ATQEQRLTYLPPPWGECRSSEMGLD------FFPVYSITACRIDCETRYIVENCNCRMVH 326
Query: 414 QPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPS 473
+P A +C +QH + + E+ +C+ C+ + S+ + PS
Sbjct: 327 --MPGDAPFCTPEQHKECA----EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPS 380
Query: 474 VVSEKWLLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEML 527
S K+L KK NK++ + L IF++ LN +I + A + L
Sbjct: 381 KTSAKYL------------EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
Query: 528 LSNFGGQLGLWMSCSVVCVIEIIEVFF 554
L + GGQ+GL++ S++ ++E+ + +
Sbjct: 429 LGDIGGQMGLFIGASILTILELFDYIY 455
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/79 (36%), Positives = 47/79 (59%), Gaps = 5/79 (6%)
Query: 35 NTNT-HGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCALLV---FSFYTVSVSIKVHF 89
NT+T HG R I V +RR+LW + ++ L+L + + V FS+ V+ +V
Sbjct: 22 NTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVA 81
Query: 90 RKLDFPAVTICNINPYKYS 108
+ L FPAVT+CN+N +++S
Sbjct: 82 QSLVFPAVTLCNLNGFRFS 100
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 117 bits (294), Expect = 3e-26
Identities = 94/363 (25%), Positives = 157/363 (43%), Gaps = 48/363 (13%)
Query: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309
+ ++L++C F G C A +F + +G CYTFN+ R+ L T GG+ GL+++
Sbjct: 163 HDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIM 221
Query: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363
L I ++EY P + G KV IH QDE PF++ +G + T +
Sbjct: 222 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLI 281
Query: 364 KLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYC 423
L P+ C D + + +YS+ C C +VE C C +P A YC
Sbjct: 282 YLPPPWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYC 337
Query: 424 NYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPV 483
+Q+ F+ E+ VC+ C+ + S+ + PS S K+L
Sbjct: 338 TPEQYKECADPALD----FLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA-- 391
Query: 484 LTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGL 537
KK NK++ + L IF++ LN +I + A I LL + GGQ+GL
Sbjct: 392 ----------KKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGL 441
Query: 538 WMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALD 597
++ S++ V+E+ + + +I + ++ K C + + AL
Sbjct: 442 FIGASILTVLELFDY----AYEVIKHKLCRRGK----------CQKEAKRSSADKGVALS 487
Query: 598 IDD 600
+DD
Sbjct: 488 LDD 490
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 4/114 (3%)
Query: 32 YCLNTNTHGCRRIV-VSRGRLRRLLWIGFTLTAVALILWQCALLV---FSFYTVSVSIKV 87
+ ++ HG I R L+R LW L ++A++L C V F ++ V+ +V
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
Query: 88 HFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAE 141
+L FPAVT+CN+N +++S V E L + Y P+++ E +
Sbjct: 81 AASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQ 134
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 107 bits (268), Expect = 3e-23
Identities = 82/328 (25%), Positives = 147/328 (44%), Gaps = 51/328 (15%)
Query: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309
+S +++L+ C F G C NFT M G CYTFN+ + +L+T+ GG GL ++
Sbjct: 155 HSLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIM 213
Query: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363
L + +EEY P + G +V IH Q+E P ++ +G + T + +
Sbjct: 214 LDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLS 273
Query: 364 KLSEPYSQCTED--------------GSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGC 409
L P+ C+ GS P + Y+L C +C + KCGC
Sbjct: 274 FLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPS---PPYTLMGCRLACETRYVARKCGC 330
Query: 410 AQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLA 469
+P C+ QQ+ N C + A ++++ C C+ + S+
Sbjct: 331 RMVY--MPGDVPVCSPQQYKN---CAHPAIDAMLRKD---SCACPNPCASTRYAKELSMV 382
Query: 470 QWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANS 523
+ PS + ++L +KLN+++ + L IF++ LN ++ + A
Sbjct: 383 RIPSRAAARFLA------------RKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYE 430
Query: 524 IEMLLSNFGGQLGLWMSCSVVCVIEIIE 551
+ LL + GGQ+GL++ S++ ++EI++
Sbjct: 431 MSELLGDIGGQMGLFIGASLLTILEILD 458
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 16 PVTGPQ-APTIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCAL 73
P +GP+ A +R + N + HG + LRR +W + +VA L+Q A
Sbjct: 3 PTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAE 62
Query: 74 LVF---SFYTVSVSIKVHFRKLDFPAVTICNINPYKYS 108
V F+ + + +L FPAVT+CNINP + S
Sbjct: 63 RVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRS 100
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 107 bits (268), Expect = 3e-23
Identities = 82/328 (25%), Positives = 147/328 (44%), Gaps = 51/328 (15%)
Query: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309
+S +++L+ C F G C NFT M G CYTFN+ + +L+T+ GG GL ++
Sbjct: 155 HSLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIM 213
Query: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363
L + +EEY P + G +V IH Q+E P ++ +G + T + +
Sbjct: 214 LDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLS 273
Query: 364 KLSEPYSQCTED--------------GSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGC 409
L P+ C+ GS P + Y+L C +C + KCGC
Sbjct: 274 FLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPS---PPYTLMGCRLACETRYVARKCGC 330
Query: 410 AQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLA 469
+P C+ QQ+ N C + A ++++ C C+ + S+
Sbjct: 331 RMVY--MPGDVPVCSPQQYKN---CAHPAIDAMLRKD---SCACPNPCASTRYAKELSMV 382
Query: 470 QWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANS 523
+ PS + ++L +KLN+++ + L IF++ LN ++ + A
Sbjct: 383 RIPSRAAARFLA------------RKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYE 430
Query: 524 IEMLLSNFGGQLGLWMSCSVVCVIEIIE 551
+ LL + GGQ+GL++ S++ ++EI++
Sbjct: 431 MSELLGDIGGQMGLFIGASLLTILEILD 458
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 16 PVTGPQ-APTIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCAL 73
P +GP+ A +R + N + HG + LRR +W + +VA L+Q A
Sbjct: 3 PTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAE 62
Query: 74 LVF---SFYTVSVSIKVHFRKLDFPAVTICNINPYKYS 108
V F+ + + +L FPAVT+CNINP + S
Sbjct: 63 RVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRS 100
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 107 bits (268), Expect = 3e-23
Identities = 82/328 (25%), Positives = 147/328 (44%), Gaps = 51/328 (15%)
Query: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309
+S +++L+ C F G C NFT M G CYTFN+ + +L+T+ GG GL ++
Sbjct: 155 HSLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIM 213
Query: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363
L + +EEY P + G +V IH Q+E P ++ +G + T + +
Sbjct: 214 LDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLS 273
Query: 364 KLSEPYSQCTED--------------GSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGC 409
L P+ C+ GS P + Y+L C +C + KCGC
Sbjct: 274 FLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPS---PPYTLMGCRLACETRYVARKCGC 330
Query: 410 AQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLA 469
+P C+ QQ+ N C + A ++++ C C+ + S+
Sbjct: 331 RMVY--MPGDVPVCSPQQYKN---CAHPAIDAMLRKD---SCACPNPCASTRYAKELSMV 382
Query: 470 QWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANS 523
+ PS + ++L +KLN+++ + L IF++ LN ++ + A
Sbjct: 383 RIPSRAAARFLA------------RKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYE 430
Query: 524 IEMLLSNFGGQLGLWMSCSVVCVIEIIE 551
+ LL + GGQ+GL++ S++ ++EI++
Sbjct: 431 MSELLGDIGGQMGLFIGASLLTILEILD 458
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 16 PVTGPQ-APTIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCAL 73
P +GP+ A +R + N + HG + LRR +W + +VA L+Q A
Sbjct: 3 PTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAE 62
Query: 74 LVF---SFYTVSVSIKVHFRKLDFPAVTICNINPYKYS 108
V F+ + + +L FPAVT+CNINP + S
Sbjct: 63 RVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRS 100
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 101 bits (251), Expect = 2e-21
Identities = 84/318 (26%), Positives = 145/318 (45%), Gaps = 27/318 (8%)
Query: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNREN-ETILSTSMGGSEYGLQVI 309
Y L+ C F G C ++F +GNC+TFN+ E + S+ G GL ++
Sbjct: 176 YLNNSTLLDCEFFGKPCSPKDFAHVFTE-YGNCFTFNHGETLQAKRKVSVSGR--GLSLL 232
Query: 310 LYINEEEY--NPFL-VSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLS 366
+N+E + NP L G +IH + P + +G M + + ++
Sbjct: 233 FNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQE 292
Query: 367 EPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQ 426
P+ +C + + ++N ++YS CL C + ++CGC + LP C+ Q
Sbjct: 293 YPWGECNPN---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFL--LPGYGIECDLQ 345
Query: 427 QHPNWMYCYYQLHRAFVQEELGC----QSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLP 482
++ C + ++L S C +C E+ T S + +PS + K+L
Sbjct: 346 KY---FSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSK 402
Query: 483 VLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCS 542
L ++K + +L K+ I Y DLN + + A S+ LL++ GGQLGL+ S
Sbjct: 403 KLNQ------SRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGAS 456
Query: 543 VVCVIEIIEVFFIDFFSI 560
++ +IEIIE F +F+ I
Sbjct: 457 LITIIEIIEYLFTNFYWI 474
Score = 67.4 bits (163), Expect = 4e-11
Identities = 37/109 (33%), Positives = 65/109 (59%), Gaps = 6/109 (5%)
Query: 5 EKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAV 64
EKIK + K P+ P K+ + ++T+ HG IV +R ++RR+LW+ L +V
Sbjct: 17 EKIKLCLSKK-PLPSPTER--KKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSV 73
Query: 65 ALILWQCALLVFSFYT--VSVSIKVHF-RKLDFPAVTICNINPYKYSTV 110
+L+ WQ + + +++T + SI+V + K++FPAVT CN+N ++ V
Sbjct: 74 SLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAV 122
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 96.7 bits (239), Expect = 6e-20
Identities = 76/335 (22%), Positives = 140/335 (41%), Gaps = 36/335 (10%)
Query: 255 ELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINE 314
++L +C F G C A NF++ + +G CYTFN + + L + GG GL+++L I +
Sbjct: 302 DMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFN-ADPRSSLPSRAGGMGSGLEIMLDIQQ 359
Query: 315 EEYNPFLVSST------GAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEP 368
EEY P + G +V IH Q+E P++ +G + T + L +P
Sbjct: 360 EEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQP 419
Query: 369 YSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQP----LPPAANYCN 424
+ C + +AYS+ C C + ++++C C P + P Y
Sbjct: 420 WGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIE 479
Query: 425 YQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVL 484
H L E C C C+ + S+ + P+ S ++L
Sbjct: 480 CADHT--------LDSLGGGPEGPC--FCPTPCNLTRYGKEISMVRIPNRGSARYLA--- 526
Query: 485 TWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVV 544
+ N+ + + L +F++ L ++ + A + LL + GGQ+GL++ S++
Sbjct: 527 ---RKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASIL 583
Query: 545 CVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAP 579
++EI++ + W + K W + P
Sbjct: 584 TLLEILDYIY--------EVSWDRLKRVWRRPKTP 610
Score = 40.4 bits (93), Expect = 0.005
Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Query: 51 LRRLLWIGFTLTAVALILWQCALLVFSFYT----VSVSIKVHFRKLDFPAVTICNINPYK 106
LRR LW LT++A L+Q A L + T V++ FPAVT+CNIN ++
Sbjct: 192 LRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFR 251
Query: 107 YSTV 110
+S +
Sbjct: 252 HSAL 255
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 96.3 bits (238), Expect = 8e-20
Identities = 79/291 (27%), Positives = 125/291 (42%), Gaps = 34/291 (11%)
Query: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309
+ ++L++C F G C A +F + +G CYTFN+ R+ L T GG+ GL+++
Sbjct: 163 HDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIM 221
Query: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363
L I ++EY P + G KV IH QDE PF++ +G + T +
Sbjct: 222 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLI 281
Query: 364 KLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYC 423
L P+ C D + + +YS+ C C +VE C C +P A YC
Sbjct: 282 YLPPPWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYC 337
Query: 424 NYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPV 483
+Q+ F+ E+ VC+ C+ + S+ + PS S K+L
Sbjct: 338 TPEQYKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA-- 391
Query: 484 LTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEMLL 528
KK NK++ + L IF++ LN +I + A I LL
Sbjct: 392 ----------KKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLL 432
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 4/114 (3%)
Query: 32 YCLNTNTHGCRRIV-VSRGRLRRLLWIGFTLTAVALILWQCALLV---FSFYTVSVSIKV 87
+ ++ HG I R L+R LW L ++A++L C V F ++ V+ +V
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
Query: 88 HFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAE 141
+L FPAVT+CN+N +++S V E L + Y P+++ E +
Sbjct: 81 AASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQ 134
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 92.8 bits (229), Expect = 9e-19
Identities = 72/331 (21%), Positives = 138/331 (41%), Gaps = 47/331 (14%)
Query: 255 ELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINE 314
++L +C F G C A NF++ + +G CYTFN + + L + GG GL+++L I +
Sbjct: 302 DMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFN-ADPRSSLPSRAGGMGSGLEIMLDIQQ 359
Query: 315 EEYNPFLVSST------GAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEP 368
EEY P + G +V IH Q+E P++ +G + T + L +P
Sbjct: 360 EEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQP 419
Query: 369 YSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQH 428
+ C + +AYS+ C C + ++++C C P + +
Sbjct: 420 WGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP----DSLGGGPEG 475
Query: 429 PNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQ 488
P C+ C C+ + S+ + P+ S ++L +
Sbjct: 476 P----CF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLA------R 508
Query: 489 GRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIE 548
N+ + + L +F++ L ++ + A + LL + GGQ+GL++ S++ ++E
Sbjct: 509 KYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568
Query: 549 IIEVFFIDFFSIIARRQWQKAKEWWAWKQAP 579
I++ + W + K W + P
Sbjct: 569 ILDYIY--------EVSWDRLKRVWRRPKTP 591
Score = 40.4 bits (93), Expect = 0.005
Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Query: 51 LRRLLWIGFTLTAVALILWQCALLVFSFYT----VSVSIKVHFRKLDFPAVTICNINPYK 106
LRR LW LT++A L+Q A L + T V++ FPAVT+CNIN ++
Sbjct: 192 LRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFR 251
Query: 107 YSTV 110
+S +
Sbjct: 252 HSAL 255
>gi|169210192 PREDICTED: hypothetical protein [Homo sapiens]
Length = 194
Score = 31.6 bits (70), Expect = 2.4
Identities = 19/48 (39%), Positives = 21/48 (43%), Gaps = 1/48 (2%)
Query: 577 QAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPP 624
Q+P CP R P G NP + L PPA GTQ P PP
Sbjct: 56 QSPGCPRQARGPGGGGNPGDTVLTPLSAPADPNTHPPAPGTQ-PALPP 102
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 31.6 bits (70), Expect = 2.4
Identities = 19/49 (38%), Positives = 21/49 (42%), Gaps = 5/49 (10%)
Query: 577 QAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPP 625
QAPP P +P P PA + DLP PP VP PPP
Sbjct: 564 QAPPLPGSPEPP-----PAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPP 607
>gi|239753568 PREDICTED: hypothetical protein [Homo sapiens]
Length = 352
Score = 30.8 bits (68), Expect = 4.1
Identities = 21/63 (33%), Positives = 23/63 (36%), Gaps = 6/63 (9%)
Query: 582 PEAPR------SPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERA 635
PEAPR NPA D D + +SA P A PG P P L
Sbjct: 234 PEAPRPGPHRRGASRNQNPADDYTDKIVPPSSASRAPTAPPAHAPGVPAPPTAALSFNLH 293
Query: 636 FSN 638
F N
Sbjct: 294 FQN 296
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 30.4 bits (67), Expect = 5.3
Identities = 29/112 (25%), Positives = 43/112 (38%), Gaps = 11/112 (9%)
Query: 217 YTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFH 276
Y + A WY LHY +Q P +++ +Y E DG S H
Sbjct: 266 YLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAE---DGRSS--------H 314
Query: 277 HPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAK 328
H T ++ + + S SEY Q +L NE E + F +S + K
Sbjct: 315 HRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLK 366
>gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo
sapiens]
Length = 1235
Score = 30.4 bits (67), Expect = 5.3
Identities = 20/49 (40%), Positives = 22/49 (44%), Gaps = 4/49 (8%)
Query: 580 PCPEAPRS-PQGQDNPALDI---DDDLPTFNSALHLPPALGTQVPGTPP 624
PCP+ + PQ Q P L D DL A PP L TQ P PP
Sbjct: 298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPP 346
>gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo
sapiens]
Length = 1259
Score = 30.4 bits (67), Expect = 5.3
Identities = 20/49 (40%), Positives = 22/49 (44%), Gaps = 4/49 (8%)
Query: 580 PCPEAPRS-PQGQDNPALDI---DDDLPTFNSALHLPPALGTQVPGTPP 624
PCP+ + PQ Q P L D DL A PP L TQ P PP
Sbjct: 298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPP 346
>gi|239758021 PREDICTED: hypothetical protein [Homo sapiens]
Length = 195
Score = 30.0 bits (66), Expect = 6.9
Identities = 12/40 (30%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 564 RQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLP 603
R+W + WW +Q PP PE + P+ + P +++ P
Sbjct: 77 RRWDLWRLWWL-RQQPPPPELQQPPELEPQPPPELEPQQP 115
>gi|239741335 PREDICTED: hypothetical protein XP_002342177 [Homo
sapiens]
Length = 214
Score = 30.0 bits (66), Expect = 6.9
Identities = 12/40 (30%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 564 RQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLP 603
R+W + WW +Q PP PE + P+ + P +++ P
Sbjct: 77 RRWDLWRLWWL-RQQPPPPELQQPPELEPQPPPELEPQQP 115
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 30.0 bits (66), Expect = 6.9
Identities = 17/57 (29%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 21 QAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFS 77
Q+ TI L +W CL+ + GCRR + +L+ + +G + VA+ ++ FS
Sbjct: 5 QSTTITSLEKW-CLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS 60
>gi|32307177 forkhead box G1 [Homo sapiens]
Length = 489
Score = 30.0 bits (66), Expect = 6.9
Identities = 21/47 (44%), Positives = 23/47 (48%), Gaps = 10/47 (21%)
Query: 579 PPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPP 625
PP P AP+ PQ + PA D DD P L LPP P PPP
Sbjct: 76 PPPPPAPQPPQTRGAPAAD-DDKGP---QQLLLPP------PPPPPP 112
>gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]
Length = 639
Score = 30.0 bits (66), Expect = 6.9
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 10/46 (21%)
Query: 580 PCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPP 625
P P PR+P DLP+ +++ LP T+ P +PPP
Sbjct: 157 PAPTTPRTPT----------PDLPSSSNSSVLPTPPATEAPSSPPP 192
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 29.6 bits (65), Expect = 9.1
Identities = 19/71 (26%), Positives = 27/71 (38%), Gaps = 3/71 (4%)
Query: 579 PPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSN 638
PP P+ P+ P Q PA P P Q P PPP+ + + +N
Sbjct: 1653 PPPPQQPQPPPPQPQPA---PQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNN 1709
Query: 639 QLTDTQMLDEL 649
T M+ E+
Sbjct: 1710 SFTPAPMIMEI 1720
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 29.6 bits (65), Expect = 9.1
Identities = 19/71 (26%), Positives = 27/71 (38%), Gaps = 3/71 (4%)
Query: 579 PPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSN 638
PP P+ P+ P Q PA P P Q P PPP+ + + +N
Sbjct: 1653 PPPPQQPQPPPPQPQPA---PQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNN 1709
Query: 639 QLTDTQMLDEL 649
T M+ E+
Sbjct: 1710 SFTPAPMIMEI 1720
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,694,060
Number of Sequences: 37866
Number of extensions: 1242555
Number of successful extensions: 3769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3644
Number of HSP's gapped (non-prelim): 52
length of query: 649
length of database: 18,247,518
effective HSP length: 109
effective length of query: 540
effective length of database: 14,120,124
effective search space: 7624866960
effective search space used: 7624866960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.