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Search of human proteins with 41281808
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281808 harmonin isoform b3 [Homo sapiens]
(899 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281808 harmonin isoform b3 [Homo sapiens] 1810 0.0
gi|71480164 harmonin isoform a [Homo sapiens] 791 0.0
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 141 3e-33
gi|13376349 PDZ domain containing 7 [Homo sapiens] 108 3e-23
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 78 3e-14
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 78 4e-14
gi|45827729 scribble isoform b [Homo sapiens] 75 3e-13
gi|45827731 scribble isoform a [Homo sapiens] 75 3e-13
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 74 5e-13
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 74 5e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 73 1e-12
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 72 2e-12
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 72 2e-12
gi|148746189 multiple PDZ domain protein [Homo sapiens] 72 3e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 70 9e-12
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 67 7e-11
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 67 7e-11
gi|56549694 enabled homolog isoform a [Homo sapiens] 67 1e-10
gi|39930375 enabled homolog isoform b [Homo sapiens] 67 1e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 66 1e-10
gi|112382257 InaD-like [Homo sapiens] 66 2e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 65 2e-10
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 65 4e-10
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 64 8e-10
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 63 1e-09
gi|160707881 formin 2 [Homo sapiens] 63 1e-09
gi|146134388 YLP motif containing 1 [Homo sapiens] 62 2e-09
gi|47132519 Ras association and pleckstrin homology domains 1 is... 61 4e-09
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 61 4e-09
gi|239752551 PREDICTED: hypothetical protein [Homo sapiens] 61 5e-09
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 1810 bits (4687), Expect = 0.0
Identities = 899/899 (100%), Positives = 899/899 (100%)
Query: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
Sbjct: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
Query: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
Sbjct: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
Query: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
Sbjct: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
Query: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
Sbjct: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
Query: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
Sbjct: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
Query: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
Sbjct: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
Query: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRK 420
EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRK
Sbjct: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRK 420
Query: 421 KGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDL 480
KGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDL
Sbjct: 421 KGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDL 480
Query: 481 EESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHT 540
EESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHT
Sbjct: 481 EESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHT 540
Query: 541 TDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTP 600
TDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTP
Sbjct: 541 TDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTP 600
Query: 601 PPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSP 660
PPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSP
Sbjct: 601 PPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSP 660
Query: 661 VPEQSFPPTPKTFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMV 720
VPEQSFPPTPKTFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMV
Sbjct: 661 VPEQSFPPTPKTFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMV 720
Query: 721 VYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV 780
VYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV
Sbjct: 721 VYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV 780
Query: 781 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC 840
VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC
Sbjct: 781 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC 840
Query: 841 PPKEYDDELASLPSSVAESPQPVRKLLEDRAAVHRHGFLLQLEPTDLLLKSKRGNQIHR 899
PPKEYDDELASLPSSVAESPQPVRKLLEDRAAVHRHGFLLQLEPTDLLLKSKRGNQIHR
Sbjct: 841 PPKEYDDELASLPSSVAESPQPVRKLLEDRAAVHRHGFLLQLEPTDLLLKSKRGNQIHR 899
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 791 bits (2044), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
Sbjct: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
Query: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
Sbjct: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
Query: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
Sbjct: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
Query: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
Sbjct: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
Query: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
Sbjct: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
Query: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
Sbjct: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
Query: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK 403
EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK
Sbjct: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK 403
Score = 249 bits (635), Expect = 1e-65
Identities = 122/122 (100%), Positives = 122/122 (100%)
Query: 728 QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER 787
QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER
Sbjct: 428 QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER 487
Query: 788 GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD 847
GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD
Sbjct: 488 GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD 547
Query: 848 EL 849
EL
Sbjct: 548 EL 549
Score = 35.4 bits (80), Expect = 0.24
Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 740 YSMFTPEQIMG-KDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 798
Y TP + K+VRL R+ EG L L++ GG++ G + +S + + G A+ G +
Sbjct: 74 YDQLTPRRSRKLKEVRLDRLHPEG-LGLSVRGGLEFGCG-LFISHLIKGGQADSVG-LQV 130
Query: 799 GDEIMAINGKIVTDYTLAE 817
GDEI+ ING ++ T E
Sbjct: 131 GDEIVRINGYSISSCTHEE 149
Score = 35.4 bits (80), Expect = 0.24
Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 74 YDQLTPRRSRKLKEVRLDRLHPEG-LGLSVRGGLEFGCG-LFISHLIKGGQADSVG-LQV 130
Y TP + K+VRL R+ EG L L++ GG++ G + +S + + G A+ G +
Sbjct: 440 YSMFTPEQIMG-KDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 498
Query: 131 GDEIVRINGYSISSCTHEE 149
GDEI+ ING ++ T E
Sbjct: 499 GDEIMAINGKIVTDYTLAE 517
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 141 bits (355), Expect = 3e-33
Identities = 106/316 (33%), Positives = 159/316 (50%), Gaps = 40/316 (12%)
Query: 11 HKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKH 70
H+ + ++AE++ L YH +V LV L+++++ P + L +R +IP
Sbjct: 43 HQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSD 102
Query: 71 QVEYDQLT----------PRR--------SRKLKEVRLDRLHP----EGLGLSVRGGLEF 108
Q+ +DQ T P R S EVRL L EGLG S+RGG E
Sbjct: 103 QLLFDQYTAEGLYLPATTPYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEH 162
Query: 109 GCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIG 168
G G+++S + G A+ GL+VGD+I+R+N S++ TH E + ++ K + + V G
Sbjct: 163 GVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAG 222
Query: 169 LIPVKSSPDEPLTWQYVD---QFVSESGGVRGSLGSP-----GNRENK--------EKKV 212
IP + TW VD + +S G+ G G+R + EKKV
Sbjct: 223 RIPGGYVTNHIYTW--VDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKV 280
Query: 213 FISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHK 272
+ L R LG +I G GI+I+ V PGS + GL++GDQI+EVNG F N+ H
Sbjct: 281 NLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHD 340
Query: 273 EAVNVLKSSRSLTISI 288
EAV +LKSSR L +++
Sbjct: 341 EAVRLLKSSRHLILTV 356
Score = 73.2 bits (178), Expect = 1e-12
Identities = 36/121 (29%), Positives = 69/121 (57%), Gaps = 3/121 (2%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSC 145
K+V L LGL++RGG E+G G++I+ + G +A+ GL+VGD+I+ +NG S +
Sbjct: 278 KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNI 337
Query: 146 THEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW---QYVDQFVSESGGVRGSLGSP 202
H+E + L+++ + + + V+ +G +P + + W + + ++ S G G L +
Sbjct: 338 LHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTE 397
Query: 203 G 203
G
Sbjct: 398 G 398
Score = 64.7 bits (156), Expect = 4e-10
Identities = 32/71 (45%), Positives = 45/71 (63%)
Query: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
GLG SI G GI++S V+PGSL+ + GL +GDQI+ VN + + H EAV LK
Sbjct: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKG 210
Query: 281 SRSLTISIVAA 291
S+ L +S+ +A
Sbjct: 211 SKKLVLSVYSA 221
Score = 36.6 bits (83), Expect = 0.11
Identities = 86/385 (22%), Positives = 144/385 (37%), Gaps = 56/385 (14%)
Query: 479 DLEES-EKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVS---PLAPPLRRFAG 534
DLEE+ E +Q + L ++ + S +S P PPP + PL P +
Sbjct: 546 DLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGRE 605
Query: 535 GLHLHTTDLDDIPLDMFYYP------------PKTPSAL-----PVMPHPPPSNPPHKVP 577
L + + +F P P T SA P+ P+NP K P
Sbjct: 606 DLQ-PPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPSSKRP 664
Query: 578 APPVLPLSGHVSASSSPWVQRTPPPIPIPPPPS-VPTQDLTPTRPLPSALEEALSNHPFR 636
L L P VQ +PP + P + V L P P S HP +
Sbjct: 665 LDAHLALVNQHPIGPFPRVQ-SPPHLKSPSAEATVAGGCLLPPSP---------SGHPDQ 714
Query: 637 TGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQPPRGPGVSTISKPVMVHQ 696
TG T E +P + V PQ +S +S
Sbjct: 715 TG-TNQHFVMVEVHRPDSEPDVNEVRAL------------PQTRTASTLSHLSDSGQTLS 761
Query: 697 EPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLL 756
E + + A ++E ++ V ++ ++ + E D + P ++ L+
Sbjct: 762 EDSGV--DAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANK--PPGLLEPTSTLV 817
Query: 757 RIKKEGS-LDLALEGGVDS--PIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDY 813
R+KK + L +A+EGG ++ P+ ++V + G+A G + G I+ +NG +
Sbjct: 818 RVKKSAATLGIAIEGGANTRQPLPRIV--TIQRGGSAHNCGQLKVGHVILEVNGLTLRGK 875
Query: 814 TLAEAEAALQKAW-NQGGDWIDLVV 837
EA + +A+ + D+ID +V
Sbjct: 876 EHREAARIIAEAFKTKDRDYIDFLV 900
Score = 35.8 bits (81), Expect = 0.18
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 753 VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 812
V L R K L ++ GG + +G + VS V AE+ G V GD+I+ +N K +
Sbjct: 141 VSLRRAKAHEGLGFSIRGGSEHGVG-IYVSLVEPGSLAEKEGLRV-GDQILRVNDKSLAR 198
Query: 813 YTLAEAEAALQ 823
T AEA AL+
Sbjct: 199 VTHAEAVKALK 209
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 108 bits (269), Expect = 3e-23
Identities = 68/208 (32%), Positives = 109/208 (52%), Gaps = 7/208 (3%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISS 144
+ VR+++ LG SVRGG E G G+F+S + +G A+ GL VGD+I +NG S+ S
Sbjct: 84 IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLES 143
Query: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYV--DQFVSESGGVRGSLGSP 202
T + ++ + + + VR +G +P E TW V + V E GS S
Sbjct: 144 TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEK---CGSTPSD 200
Query: 203 GNRENKEKKVFISLVGSRG--LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVE 260
+ E+ +++ S LG +I G GI++S V G L+ E G+++GDQ++
Sbjct: 201 TSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLA 260
Query: 261 VNGVDFSNLDHKEAVNVLKSSRSLTISI 288
NGV F ++ H +AV VLK + ++I
Sbjct: 261 ANGVRFDDISHSQAVEVLKGQTHIMLTI 288
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/150 (27%), Positives = 71/150 (47%), Gaps = 15/150 (10%)
Query: 98 LGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTK 157
LG ++RGG EFG G+++S + GG A+ G++VGD+++ NG +H + + +++ +
Sbjct: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQ 281
Query: 158 KTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLV 217
+ + ++ G P W +D+ S GV L SP + + S V
Sbjct: 282 THIMLTIKETGRYPAYKEMVSEYCW--LDRL---SNGVLQQL-SPASESS-------SSV 328
Query: 218 GSRGLGCSISSG--PIQKPGIFISHVKPGS 245
S SSG P + I + +PGS
Sbjct: 329 SSCASSAPYSSGSLPSDRMDICLGQEEPGS 358
Score = 33.9 bits (76), Expect = 0.70
Identities = 23/72 (31%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 753 VRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIV 810
+ +R++K G L ++ GG + +G + VS V E +AER G+ GD+I +NG +
Sbjct: 84 IHSVRVEKSPAGRLGFSVRGGSEHGLG-IFVSKVEEGSSAER-AGLCVGDKITEVNGLSL 141
Query: 811 TDYTLAEAEAAL 822
T+ A L
Sbjct: 142 ESTTMGSAVKVL 153
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 78.2 bits (191), Expect = 3e-14
Identities = 104/428 (24%), Positives = 188/428 (43%), Gaps = 62/428 (14%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
S K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+++
Sbjct: 314 SEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV-------RHIGLIP--VKSSPDEPLTWQYV 185
+N + THEE + ++ T V +KV + G P + +S +P V
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP-----V 427
Query: 186 DQFVSESGGVRGSLGSP-----------GNRE-NKEKKVFISLVGSRGLGCSISSGPIQK 233
D VS S + + SP G+ E +E + + GS GLG +I G
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE-DG 486
Query: 234 PGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVA 290
GIFIS + P LS E L GD+I+ VN VD H++A LK++ ++IVA
Sbjct: 487 EGIFISFILAGGPADLSGE--LRKGDRIISVNSVDLRAASHEQAAAALKNA-GQAVTIVA 543
Query: 291 AAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAA 350
E + ++ + R++ + L + L + + + K+ +
Sbjct: 544 QYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ 603
Query: 351 EENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYR 410
N ++ + I ++++ W +++ + P + EV +P ++ +
Sbjct: 604 GLNFKFGDILHVINASDDEW-------WQARQ--VTPDGESDEVGVIPSKRRVE----KK 650
Query: 411 YDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQK--LYKEKEEMLEKEKQLKINRL 468
+ T++ K + K + S D K KK L F +K YK K++ E+E +
Sbjct: 651 ERARLKTVKFNSKTRDKGQ--SFND--KRKKNL-FSRKFPFYKNKDQS-EQETSDADQHV 704
Query: 469 AQEVSETE 476
S++E
Sbjct: 705 TSNASDSE 712
Score = 56.2 bits (134), Expect = 1e-07
Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 51/228 (22%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEF-----GCGLFISHLIKGGQADSVG-LQVGDEIVRING 139
+E+ L+R + GLG S+ GG + +FI+ +I GG A G L+V D I+R+N
Sbjct: 223 EEITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 140 YSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSL 199
+ TH + + ++ ++ V +V V
Sbjct: 282 VDVRDVTHSKAVEALKEAGSI------------------------VRLYVKRRKPV---- 313
Query: 200 GSPGNRENKEKKVFISLV-GSRGLGCSISSGPIQK--PG---IFISHVKPGSLSAEVG-L 252
EK + I L+ G +GLG SI+ G + PG I+++ + G + + G L
Sbjct: 314 --------SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
+IGD+++ VN V + H+EAV LK++ + + A ++M D
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMND 412
Score = 40.0 bits (92), Expect = 0.010
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 9/117 (7%)
Query: 751 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 806
K + + IK L ++ GGV + + V+ + E GAA + G + GD+++A+N
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 807 GKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELASLPSSVAESPQPV 863
+ + T EA AL+ D++ L VA P Y ++ + P S QPV
Sbjct: 376 NVCLEEVTHEEAVTALKNT----SDFVYLKVAK-PTSMYMNDGYAPPDITNSSSQPV 427
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 77.8 bits (190), Expect = 4e-14
Identities = 76/260 (29%), Positives = 125/260 (48%), Gaps = 41/260 (15%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
S K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+++
Sbjct: 314 SEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV-------RHIGLIP--VKSSPDEPLTWQYV 185
+N + THEE + ++ T V +KV + G P + +S +P V
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP-----V 427
Query: 186 DQFVSESGGVRGSLGSP-----------GNRE-NKEKKVFISLVGSRGLGCSISSGPIQK 233
D VS S + + SP G+ E +E + + GS GLG +I G
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE-DG 486
Query: 234 PGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVA 290
GIFIS + P LS E L GD+I+ VN VD H++A LK++ ++IVA
Sbjct: 487 EGIFISFILAGGPADLSGE--LRKGDRIISVNSVDLRAASHEQAAAALKNA-GQAVTIVA 543
Query: 291 AAGRELFMTDRERLAEARQR 310
E + ++ + R++
Sbjct: 544 QYRPEEYSRFEAKIHDLREQ 563
Score = 56.2 bits (134), Expect = 1e-07
Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 51/228 (22%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEF-----GCGLFISHLIKGGQADSVG-LQVGDEIVRING 139
+E+ L+R + GLG S+ GG + +FI+ +I GG A G L+V D I+R+N
Sbjct: 223 EEITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 140 YSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSL 199
+ TH + + ++ ++ V +V V
Sbjct: 282 VDVRDVTHSKAVEALKEAGSI------------------------VRLYVKRRKPV---- 313
Query: 200 GSPGNRENKEKKVFISLV-GSRGLGCSISSGPIQK--PG---IFISHVKPGSLSAEVG-L 252
EK + I L+ G +GLG SI+ G + PG I+++ + G + + G L
Sbjct: 314 --------SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
+IGD+++ VN V + H+EAV LK++ + + A ++M D
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMND 412
Score = 40.0 bits (92), Expect = 0.010
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 9/117 (7%)
Query: 751 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 806
K + + IK L ++ GGV + + V+ + E GAA + G + GD+++A+N
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 807 GKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELASLPSSVAESPQPV 863
+ + T EA AL+ D++ L VA P Y ++ + P S QPV
Sbjct: 376 NVCLEEVTHEEAVTALKNT----SDFVYLKVAK-PTSMYMNDGYAPPDITNSSSQPV 427
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/214 (30%), Positives = 108/214 (50%), Gaps = 26/214 (12%)
Query: 97 GLGLSVRGGLEFGC------GLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEV 150
GLG+S+ GG G+FIS + + G A G++VGD+++ +NG ++ H E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796
Query: 151 INLIRTKKT-VSIKV-RHIGLIPVKSSPDEPLTWQYVDQF---VSESGGVRGSL---GSP 202
+ +R T V ++V R + P + PL + D + GG+R L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPE--DDYSPRERRGGGLRLPLLPPESP 854
Query: 203 GNRENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVG-LEIG 255
G +++ V RGLG SI+ G P GIF+S + G + G L++G
Sbjct: 855 G--PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 256 DQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
D+++ +NGVD + H AV++L ++ S TI+++
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLL-TAASPTIALL 945
Score = 72.0 bits (175), Expect = 2e-12
Identities = 68/227 (29%), Positives = 106/227 (46%), Gaps = 51/227 (22%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLE-----FGC---GLFISHLIKGGQADSVGLQVGDEIVR 136
++E+RL R LGLS+ GG + FG G+FIS ++ G A GL+VGD I+
Sbjct: 1002 VEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILA 1060
Query: 137 INGYSISSCTHEEVIN-LIRTKKTVSIKVRHIGLIP------VKSSPDEPLTWQYVDQFV 189
+NG + TH+E ++ L+R +S+ VR P ++ +P E L +
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLG-------I 1113
Query: 190 SESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKP-GSLSA 248
S GG RG G+P + ++ GIFIS V P G+
Sbjct: 1114 SIRGGARGHAGNPRDPTDE--------------------------GIFISKVSPTGAAGR 1147
Query: 249 EVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRE 295
+ L +G +++EVN L H EAV +L+S T++++ G E
Sbjct: 1148 DGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD-TLTVLVCDGFE 1193
Score = 50.8 bits (120), Expect = 6e-06
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 6/83 (7%)
Query: 205 RENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVGLEIGDQI 258
R +E+ L + GLG SI+ G P GIFIS V +A G+ +GD++
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 259 VEVNGVDFSNLDHKEAVNVLKSS 281
+EVNGV +H EAV L+ +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA 803
Score = 39.3 bits (90), Expect = 0.017
Identities = 32/79 (40%), Positives = 43/79 (54%), Gaps = 10/79 (12%)
Query: 751 KDVRLLRIKKEGSLDLALEGGVDS---PIGK----VVVSAVYERGAAERHGGIVKGDEIM 803
+++RL R G L L++ GG D P G V +S V RG A R G+ GD I+
Sbjct: 1003 EEIRLPRAG--GPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRVGDRIL 1059
Query: 804 AINGKIVTDYTLAEAEAAL 822
A+NG+ V D T EA +AL
Sbjct: 1060 AVNGQDVRDATHQEAVSAL 1078
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 759 KKEGSLDLALEGGVDSPIGK-----VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 812
+ E L ++ GG S + + VS + E GAA R G + GD +++ING VT+
Sbjct: 867 RSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/214 (30%), Positives = 108/214 (50%), Gaps = 26/214 (12%)
Query: 97 GLGLSVRGGLEFGC------GLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEV 150
GLG+S+ GG G+FIS + + G A G++VGD+++ +NG ++ H E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796
Query: 151 INLIRTKKT-VSIKV-RHIGLIPVKSSPDEPLTWQYVDQF---VSESGGVRGSL---GSP 202
+ +R T V ++V R + P + PL + D + GG+R L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPE--DDYSPRERRGGGLRLPLLPPESP 854
Query: 203 GNRENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVG-LEIG 255
G +++ V RGLG SI+ G P GIF+S + G + G L++G
Sbjct: 855 G--PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 256 DQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
D+++ +NGVD + H AV++L ++ S TI+++
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLL-TAASPTIALL 945
Score = 72.0 bits (175), Expect = 2e-12
Identities = 68/227 (29%), Positives = 106/227 (46%), Gaps = 51/227 (22%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLE-----FGC---GLFISHLIKGGQADSVGLQVGDEIVR 136
++E+RL R LGLS+ GG + FG G+FIS ++ G A GL+VGD I+
Sbjct: 1002 VEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILA 1060
Query: 137 INGYSISSCTHEEVIN-LIRTKKTVSIKVRHIGLIP------VKSSPDEPLTWQYVDQFV 189
+NG + TH+E ++ L+R +S+ VR P ++ +P E L +
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLG-------I 1113
Query: 190 SESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKP-GSLSA 248
S GG RG G+P + ++ GIFIS V P G+
Sbjct: 1114 SIRGGARGHAGNPRDPTDE--------------------------GIFISKVSPTGAAGR 1147
Query: 249 EVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRE 295
+ L +G +++EVN L H EAV +L+S T++++ G E
Sbjct: 1148 DGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD-TLTVLVCDGFE 1193
Score = 50.8 bits (120), Expect = 6e-06
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 6/83 (7%)
Query: 205 RENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVGLEIGDQI 258
R +E+ L + GLG SI+ G P GIFIS V +A G+ +GD++
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 259 VEVNGVDFSNLDHKEAVNVLKSS 281
+EVNGV +H EAV L+ +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA 803
Score = 39.3 bits (90), Expect = 0.017
Identities = 32/79 (40%), Positives = 43/79 (54%), Gaps = 10/79 (12%)
Query: 751 KDVRLLRIKKEGSLDLALEGGVDS---PIGK----VVVSAVYERGAAERHGGIVKGDEIM 803
+++RL R G L L++ GG D P G V +S V RG A R G+ GD I+
Sbjct: 1003 EEIRLPRAG--GPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRVGDRIL 1059
Query: 804 AINGKIVTDYTLAEAEAAL 822
A+NG+ V D T EA +AL
Sbjct: 1060 AVNGQDVRDATHQEAVSAL 1078
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 759 KKEGSLDLALEGGVDSPIGK-----VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 812
+ E L ++ GG S + + VS + E GAA R G + GD +++ING VT+
Sbjct: 867 RSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 74.3 bits (181), Expect = 5e-13
Identities = 73/261 (27%), Positives = 126/261 (48%), Gaps = 37/261 (14%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
+ K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+I+
Sbjct: 198 AEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV---RHIGLIPVKSSPDEPLTW-QYVDQFVS 190
+N + HE+ + ++ T V +KV + L + PD ++ Q++D +S
Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 316
Query: 191 ESGGVRGSLG-----------SPGNRE-------NKEKKVFISLVGSRGLGCSISSGPIQ 232
S + SP ++ +E + + GS GLG +I G
Sbjct: 317 HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE-D 375
Query: 233 KPGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
GIFIS + P LS E L GDQI+ VNGVD N H++A LK++ T++I+
Sbjct: 376 GEGIFISFILAGGPADLSGE--LRKGDQILSVNGVDLRNASHEQAAIALKNA-GQTVTII 432
Query: 290 AAAGRELFMTDRERLAEARQR 310
A E + ++ + R++
Sbjct: 433 AQYKPEEYSRFEAKIHDLREQ 453
Score = 45.1 bits (105), Expect = 3e-04
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 218 GSRGLGCSISSGPIQK-----PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
G+ GLG SI+ G P IFI+ + PG +A+ G L + D I+ VN VD + H
Sbjct: 114 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 173
Query: 272 KEAVNVLKSSRSL 284
AV LK + S+
Sbjct: 174 SAAVEALKEAGSI 186
Score = 35.4 bits (80), Expect = 0.24
Identities = 23/81 (28%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 751 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 806
K + + IK L ++ GGV + + V+ + E GAA + G + GD+I+A+N
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 807 GKIVTDYTLAEAEAALQKAWN 827
+ D +A AAL+ ++
Sbjct: 260 SVGLEDVMHEDAVAALKNTYD 280
Score = 32.7 bits (73), Expect = 1.6
Identities = 26/100 (26%), Positives = 49/100 (49%), Gaps = 7/100 (7%)
Query: 746 EQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAI 805
E I + R++ + L + GG D + +S + G A+ G + KGD+I+++
Sbjct: 348 EDIPREPRRIVIHRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSV 405
Query: 806 NGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEY 845
NG + + + +A AL+ A G + ++A P+EY
Sbjct: 406 NGVDLRNASHEQAAIALKNA----GQTV-TIIAQYKPEEY 440
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 74.3 bits (181), Expect = 5e-13
Identities = 73/261 (27%), Positives = 126/261 (48%), Gaps = 37/261 (14%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
+ K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+I+
Sbjct: 152 AEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV---RHIGLIPVKSSPDEPLTW-QYVDQFVS 190
+N + HE+ + ++ T V +KV + L + PD ++ Q++D +S
Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 270
Query: 191 ESGGVRGSLG-----------SPGNRE-------NKEKKVFISLVGSRGLGCSISSGPIQ 232
S + SP ++ +E + + GS GLG +I G
Sbjct: 271 HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE-D 329
Query: 233 KPGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
GIFIS + P LS E L GDQI+ VNGVD N H++A LK++ T++I+
Sbjct: 330 GEGIFISFILAGGPADLSGE--LRKGDQILSVNGVDLRNASHEQAAIALKNA-GQTVTII 386
Query: 290 AAAGRELFMTDRERLAEARQR 310
A E + ++ + R++
Sbjct: 387 AQYKPEEYSRFEAKIHDLREQ 407
Score = 45.1 bits (105), Expect = 3e-04
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 218 GSRGLGCSISSGPIQK-----PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
G+ GLG SI+ G P IFI+ + PG +A+ G L + D I+ VN VD + H
Sbjct: 68 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
Query: 272 KEAVNVLKSSRSL 284
AV LK + S+
Sbjct: 128 SAAVEALKEAGSI 140
Score = 35.4 bits (80), Expect = 0.24
Identities = 23/81 (28%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 751 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 806
K + + IK L ++ GGV + + V+ + E GAA + G + GD+I+A+N
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 807 GKIVTDYTLAEAEAALQKAWN 827
+ D +A AAL+ ++
Sbjct: 214 SVGLEDVMHEDAVAALKNTYD 234
Score = 32.7 bits (73), Expect = 1.6
Identities = 26/100 (26%), Positives = 49/100 (49%), Gaps = 7/100 (7%)
Query: 746 EQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAI 805
E I + R++ + L + GG D + +S + G A+ G + KGD+I+++
Sbjct: 302 EDIPREPRRIVIHRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSV 359
Query: 806 NGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEY 845
NG + + + +A AL+ A G + ++A P+EY
Sbjct: 360 NGVDLRNASHEQAAIALKNA----GQTV-TIIAQYKPEEY 394
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 73.2 bits (178), Expect = 1e-12
Identities = 86/317 (27%), Positives = 141/317 (44%), Gaps = 49/317 (15%)
Query: 37 MDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRK----LKEVRLDR 92
MD + V D L +NE + + R + LK +L RR + + EV L +
Sbjct: 173 MDGRLGVNDCVLRVNEVDVSEVVHS-RAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLK 231
Query: 93 LHPEGLGLSVRGGL-----EFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCT 146
P+GLG S+ GG+ ++I+ +I+GG A G LQ+GD ++ +N ++
Sbjct: 232 -GPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVR 290
Query: 147 HEEVI-NLIRTKKTVSIKVRHIGLIPVK---SSPDEPLTWQYV-DQFVSES------GGV 195
HEE + +L T V +KV G + + + PD T+ + D +S + G V
Sbjct: 291 HEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAV 350
Query: 196 RGSLGSPGNRE-------------------NKEKKVFISLVGSRGLGCSISSGPIQKPGI 236
+ P + +E + I GS GLG +I G GI
Sbjct: 351 ESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGE-DGEGI 409
Query: 237 FISHVK---PGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAG 293
F+S + P LS E L GD+I+ VNGV+ N H++A LK + +++IVA
Sbjct: 410 FVSFILAGGPADLSGE--LRRGDRILSVNGVNLRNATHEQAAAALKRA-GQSVTIVAQYR 466
Query: 294 RELFMTDRERLAEARQR 310
E + ++ + R++
Sbjct: 467 PEEYSRFESKIHDLREQ 483
Score = 44.3 bits (103), Expect = 5e-04
Identities = 28/70 (40%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 218 GSRGLGCSISSG-----PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
G+ GLG SI+ G PGIFI+ + PG +A G L + D ++ VN VD S + H
Sbjct: 137 GNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVH 196
Query: 272 KEAVNVLKSS 281
AV LK +
Sbjct: 197 SRAVEALKEA 206
Score = 37.7 bits (86), Expect = 0.048
Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 7/107 (6%)
Query: 739 PYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 798
P M E + +++ K L + GG D + VS + G A+ G + +
Sbjct: 371 PRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELRR 428
Query: 799 GDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEY 845
GD I+++NG + + T +A AAL++A +VA P+EY
Sbjct: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQS-----VTIVAQYRPEEY 470
Score = 35.8 bits (81), Expect = 0.18
Identities = 25/83 (30%), Positives = 44/83 (53%), Gaps = 8/83 (9%)
Query: 745 PEQIMGKDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGD 800
PE IM +V LL+ K L ++ GG+ + + ++ + E GAA++ G + GD
Sbjct: 221 PETIM--EVNLLKGPK--GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGD 276
Query: 801 EIMAINGKIVTDYTLAEAEAALQ 823
++A+N + D EA A+L+
Sbjct: 277 RLLAVNNTNLQDVRHEEAVASLK 299
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 72.4 bits (176), Expect = 2e-12
Identities = 84/297 (28%), Positives = 118/297 (39%), Gaps = 53/297 (17%)
Query: 433 LQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVER 492
LQDL+ K L E++ +++ LE E +++L EV++ +E LE+++K +
Sbjct: 504 LQDLQGEKDALHSEKQQIATEKQDLEAE----VSQLTGEVAKLTKE-LEDAKKEMASLSA 558
Query: 493 LCQTRLEQISS-----------ADNEI--------SEMTTGPPPPPPSVSPLAPPLRRFA 533
T + S D+ + TT PPPPPP P PPL
Sbjct: 559 AAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPP--PPL---P 613
Query: 534 GGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLS-GHVSASS 592
GG+ + + PP P + P PPP + +P PP LP G S SS
Sbjct: 614 GGVCISS-------------PPSLPGGTAISP-PPPLSGDATIPPPPPLPEGVGIPSPSS 659
Query: 593 SPWVQRTPPPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNH 652
P PPP P+P +P P PLP + P G+ G P
Sbjct: 660 LPGGTAIPPPPPLPGSARIP----PPPPPLPGSAGIPPPPPPL-PGEAGMPPPPPPLPGG 714
Query: 653 SGKPTNSPVP-EQSFPPTPKTFCPSPQPPRGPGVSTISKPVM-VHQEPNFIYRPAVK 707
G P P P PP P P PP G GV + PV+ P +Y+P V+
Sbjct: 715 PGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVP--AAPVLPFGLTPKKLYKPEVQ 769
Score = 57.0 bits (136), Expect = 8e-08
Identities = 69/275 (25%), Positives = 108/275 (39%), Gaps = 41/275 (14%)
Query: 429 KYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSE------TEREDLE- 481
K G+ D + ++E E + ++M++K K K A E+ + T R +L+
Sbjct: 436 KNGADPDFKCRHLQIEIEGLI----DQMIDKTKVEKSEAKAAELEKKLDSELTARHELQV 491
Query: 482 ESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHTT 541
E +K++ E+ Q + + +E ++ T VS L + + L
Sbjct: 492 EMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKK 551
Query: 542 DLDDIPLDMFYYPPKTPSALPVMPHPP-PSNPPHKVPAPPVLPLSGHVSASSSPWVQRTP 600
++ + PP PS PV P PP P + +P PP +P TP
Sbjct: 552 EMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP------------APGDSTTP 599
Query: 601 PPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTG-NPVEDWEAKNHSGKPTNS 659
PP P PPPP P PLP + +S+ P G T +P + P
Sbjct: 600 PP-PPPPPP--------PPPPLPGGV--CISSPPSLPGGTAISPPP--PLSGDATIPPPP 646
Query: 660 PVPEQSFPPTPKTF---CPSPQPPRGPGVSTISKP 691
P+PE P+P + P PP PG + I P
Sbjct: 647 PLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPP 681
Score = 36.2 bits (82), Expect = 0.14
Identities = 29/87 (33%), Positives = 29/87 (33%), Gaps = 19/87 (21%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPH 574
PPPPP P PP F GG P P P M PPP
Sbjct: 706 PPPPPLPGGPGIPPPPPFPGG-------------------PGIPPPPPGMGMPPPPPFGF 746
Query: 575 KVPAPPVLPLSGHVSASSSPWVQRTPP 601
VPA PVLP P VQ P
Sbjct: 747 GVPAAPVLPFGLTPKKLYKPEVQLRRP 773
Score = 32.3 bits (72), Expect = 2.0
Identities = 36/173 (20%), Positives = 73/173 (42%), Gaps = 16/173 (9%)
Query: 316 ELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWE 375
EL ++ + S + LQ+ + +++ ++ ++ + E ++ VE+ F K +
Sbjct: 1031 ELAHVEKASRVSAENLQKNLDQMKKQISDV-ERDVQNFPAATDEKDKFVEKMTSFVKDAQ 1089
Query: 376 EDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQD 435
E + + H K G ++ +D K ++ + D + LQ
Sbjct: 1090 EQYNKLRMM----------HSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQA 1139
Query: 436 LRKNKKELEFEQ-----KLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEES 483
+++N+K E E+ KL KEK E EKQ K +L +E + + +S
Sbjct: 1140 VKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDS 1192
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 72.4 bits (176), Expect = 2e-12
Identities = 84/297 (28%), Positives = 118/297 (39%), Gaps = 53/297 (17%)
Query: 433 LQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVER 492
LQDL+ K L E++ +++ LE E +++L EV++ +E LE+++K +
Sbjct: 513 LQDLQGEKDALHSEKQQIATEKQDLEAE----VSQLTGEVAKLTKE-LEDAKKEMASLSA 567
Query: 493 LCQTRLEQISS-----------ADNEI--------SEMTTGPPPPPPSVSPLAPPLRRFA 533
T + S D+ + TT PPPPPP P PPL
Sbjct: 568 AAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPP--PPL---P 622
Query: 534 GGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLS-GHVSASS 592
GG+ + + PP P + P PPP + +P PP LP G S SS
Sbjct: 623 GGVCISS-------------PPSLPGGTAISP-PPPLSGDATIPPPPPLPEGVGIPSPSS 668
Query: 593 SPWVQRTPPPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNH 652
P PPP P+P +P P PLP + P G+ G P
Sbjct: 669 LPGGTAIPPPPPLPGSARIP----PPPPPLPGSAGIPPPPPPL-PGEAGMPPPPPPLPGG 723
Query: 653 SGKPTNSPVP-EQSFPPTPKTFCPSPQPPRGPGVSTISKPVM-VHQEPNFIYRPAVK 707
G P P P PP P P PP G GV + PV+ P +Y+P V+
Sbjct: 724 PGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVP--AAPVLPFGLTPKKLYKPEVQ 778
Score = 57.0 bits (136), Expect = 8e-08
Identities = 69/275 (25%), Positives = 108/275 (39%), Gaps = 41/275 (14%)
Query: 429 KYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSE------TEREDLE- 481
K G+ D + ++E E + ++M++K K K A E+ + T R +L+
Sbjct: 445 KNGADPDFKCRHLQIEIEGLI----DQMIDKTKVEKSEAKAAELEKKLDSELTARHELQV 500
Query: 482 ESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHTT 541
E +K++ E+ Q + + +E ++ T VS L + + L
Sbjct: 501 EMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKK 560
Query: 542 DLDDIPLDMFYYPPKTPSALPVMPHPP-PSNPPHKVPAPPVLPLSGHVSASSSPWVQRTP 600
++ + PP PS PV P PP P + +P PP +P TP
Sbjct: 561 EMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP------------APGDSTTP 608
Query: 601 PPIPIPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTG-NPVEDWEAKNHSGKPTNS 659
PP P PPPP P PLP + +S+ P G T +P + P
Sbjct: 609 PP-PPPPPP--------PPPPLPGGV--CISSPPSLPGGTAISPPP--PLSGDATIPPPP 655
Query: 660 PVPEQSFPPTPKTF---CPSPQPPRGPGVSTISKP 691
P+PE P+P + P PP PG + I P
Sbjct: 656 PLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPP 690
Score = 36.2 bits (82), Expect = 0.14
Identities = 29/87 (33%), Positives = 29/87 (33%), Gaps = 19/87 (21%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPH 574
PPPPP P PP F GG P P P M PPP
Sbjct: 715 PPPPPLPGGPGIPPPPPFPGG-------------------PGIPPPPPGMGMPPPPPFGF 755
Query: 575 KVPAPPVLPLSGHVSASSSPWVQRTPP 601
VPA PVLP P VQ P
Sbjct: 756 GVPAAPVLPFGLTPKKLYKPEVQLRRP 782
Score = 32.3 bits (72), Expect = 2.0
Identities = 36/173 (20%), Positives = 73/173 (42%), Gaps = 16/173 (9%)
Query: 316 ELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWE 375
EL ++ + S + LQ+ + +++ ++ ++ + E ++ VE+ F K +
Sbjct: 1040 ELAHVEKASRVSAENLQKNLDQMKKQISDV-ERDVQNFPAATDEKDKFVEKMTSFVKDAQ 1098
Query: 376 EDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQD 435
E + + H K G ++ +D K ++ + D + LQ
Sbjct: 1099 EQYNKLRMM----------HSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQA 1148
Query: 436 LRKNKKELEFEQ-----KLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEES 483
+++N+K E E+ KL KEK E EKQ K +L +E + + +S
Sbjct: 1149 VKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDS 1201
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 71.6 bits (174), Expect = 3e-12
Identities = 75/244 (30%), Positives = 119/244 (48%), Gaps = 39/244 (15%)
Query: 55 RLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFI 114
RL L+ R P K + D LT + L + +GLGLS+ G G+F+
Sbjct: 1705 RLTLY---RDEAPYKEEEVCDTLT---------IELQKKPGKGLGLSIVGKRN-DTGVFV 1751
Query: 115 SHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVK 173
S ++KGG AD+ G L GD+I+ +NG + + T E V L++ + G +
Sbjct: 1752 SDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE---------GSL--- 1799
Query: 174 SSPDEPLTWQYVDQFVSESGGVRGSLGSP--GNRENKEKKVFISLVGSRGLGCSISSG-- 229
SS PL+ + + ES + +L S G R + KK + LG SI+ G
Sbjct: 1800 SSFTFPLSGSSTSESL-ESSSKKNALASEIQGLRTVEMKKG-----PTDSLGISIAGGVG 1853
Query: 230 -PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK-SSRSLTI 286
P+ IFI+ + P ++A+ L +GD+IV + G + H +AVN+LK +S S+ +
Sbjct: 1854 SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1913
Query: 287 SIVA 290
+VA
Sbjct: 1914 QVVA 1917
Score = 66.2 bits (160), Expect = 1e-10
Identities = 78/357 (21%), Positives = 150/357 (42%), Gaps = 66/357 (18%)
Query: 98 LGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRT 156
LG++V + G G+ + +I GG G + +GD I+ IN S S T+ + ++R
Sbjct: 1018 LGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRR 1076
Query: 157 KKTVSIKVRHIGLIPVKSSPDEPLTW-------QYVDQFVSESGGVRGSLGSPGNRENKE 209
+ ++ I +P + + ++ +D F S +G L E +E
Sbjct: 1077 HSLIGPDIK-ITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEE 1135
Query: 210 ------------------------KKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGS 245
K + IS+VG RG+G +S+G + + GIFI HV S
Sbjct: 1136 SELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMR-GIFIKHVLEDS 1194
Query: 246 LSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERL 304
+ + G L+ GD+IVEV+G+D + H++AV ++ + + + +V + + R+
Sbjct: 1195 PAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV----QSIINRPRKSP 1250
Query: 305 AEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKE--------------IAQKAA 350
+ L + +S +I ++ + + E A+ +
Sbjct: 1251 LPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGS 1310
Query: 351 EENERYRKEMEQIVEEEEKFKKQWE---EDWGSKEQLLLPKTITAEVHPVPLRKPKS 404
+ + ++ Q V++E++F W+ E +G T+T E+H + L K S
Sbjct: 1311 DHTQSSASKISQDVDKEDEFGYSWKNIRERYG---------TLTGELHMIELEKGHS 1358
Score = 64.7 bits (156), Expect = 4e-10
Identities = 61/215 (28%), Positives = 101/215 (46%), Gaps = 16/215 (7%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLEFGCG---LFISHLIKGG-QADSVGLQVGDEIVRINGY 140
L+ V + + + LG+S+ GG+ G +FI+ + G A + L+VGD IV I G
Sbjct: 1831 LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 141 SISSCTHEEVINLIRTKK-TVSIKVRHIGLIPVKSS-PDEPLTWQYVDQFVSESGGVRGS 198
S TH + +NL++ ++ ++V G + V + EP + ++ S +
Sbjct: 1891 STEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD 1950
Query: 199 LGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKP----GSLSAEVGLEI 254
LG P + ++ G GLG SI G G +VK G+ S + L+
Sbjct: 1951 LGPPQCKSITLER------GPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKR 2004
Query: 255 GDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
GDQI+ VNG + H+EAV +LK ++ +V
Sbjct: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 57.8 bits (138), Expect = 5e-08
Identities = 54/188 (28%), Positives = 78/188 (41%), Gaps = 33/188 (17%)
Query: 97 GLGLSVRGGLEFGCGLFISHLI--KGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLI 154
GLGLS+ GG + G I H + +G L GD+I+ +NG + TH+E IN++
Sbjct: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697
Query: 155 RTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFI 214
R +P Y D+ + V +L + +
Sbjct: 1698 R------------------QTPQRVRLTLYRDEAPYKEEEVCDTL-----------TIEL 1728
Query: 215 SLVGSRGLGCSISSGPIQKPGIFISH-VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE 273
+GLG SI G G+F+S VK G A+ L GDQI+ VNG D N +
Sbjct: 1729 QKKPGKGLGLSI-VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEA 1787
Query: 274 AVNVLKSS 281
+LK S
Sbjct: 1788 VAALLKVS 1795
Score = 52.0 bits (123), Expect = 2e-06
Identities = 64/307 (20%), Positives = 130/307 (42%), Gaps = 36/307 (11%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
GLG + GG G+ + ++ GG AD G L GD I++I ++ + E+V ++R
Sbjct: 266 GLGFGIIGGK--ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 156 TKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLG-SPGNRENKEKKVF- 213
+ L+ + + +E + +S S L ++ +E + F
Sbjct: 324 QCGN------RVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFD 377
Query: 214 ISLVGS-RGLGCSISS----GPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFS 267
+ L + +GLG +I+ ++ GIF+ + S G ++IGDQI+ V+G +
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 268 NLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMES 327
+++AV VL+ + G+ + +T R + + R+++ L+ +
Sbjct: 438 GFTNQQAVEVLRHT-----------GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 328 NKILQEQQEMERQ-----RRKEIAQKAAEENERYRKEMEQIVE---EEEKFKKQWEEDWG 379
I++E E + R I E E+E+I + +E +W+ G
Sbjct: 487 ASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMG 546
Query: 380 SKEQLLL 386
++++
Sbjct: 547 INYEIVV 553
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/203 (27%), Positives = 81/203 (39%), Gaps = 39/203 (19%)
Query: 111 GLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRTKK-TVSIKVRHIG 168
G+ I L + G A + G L+VGD+I+ ++ + E+ I+L++T K TV + +
Sbjct: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIH--- 1561
Query: 169 LIPVKSSPDEPLTWQYVDQFVSESGGVRGSL-----GSP------GNRENKEKKVFIS-- 215
+PD E SL GSP + +F S
Sbjct: 1562 ----AENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDP 1617
Query: 216 ---------------LVGSRGLGCSISSGPIQKPGIFISH--VKPGSLSAEVGLEIGDQI 258
G GLG SI G G I H + G+ + L GDQI
Sbjct: 1618 ATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQI 1677
Query: 259 VEVNGVDFSNLDHKEAVNVLKSS 281
+EVNG+D H EA+NVL+ +
Sbjct: 1678 LEVNGIDLRKATHDEAINVLRQT 1700
Score = 43.5 bits (101), Expect = 9e-04
Identities = 23/66 (34%), Positives = 38/66 (57%)
Query: 759 KKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEA 818
K L L++ GG D+ +G +++ VYE GAA + G + GD+I+ +NG + T EA
Sbjct: 1634 KGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEA 1693
Query: 819 EAALQK 824
L++
Sbjct: 1694 INVLRQ 1699
Score = 43.1 bits (100), Expect = 0.001
Identities = 57/223 (25%), Positives = 97/223 (43%), Gaps = 30/223 (13%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRT 156
GLG+S+ + G S L +G S L GDE++ +NG ++ H++V+N+++
Sbjct: 564 GLGISLEATV--GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKE 621
Query: 157 KKTVSIKVRHIGLIPVKSSPD---------EPLTWQYVD--QFVSESGGVRGSLG-SPGN 204
V +P + + E +VD +F+ S L +
Sbjct: 622 LPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAG 681
Query: 205 RENKEKKVFISL-----------VGSRGLGCSISS--GPIQKPG--IFISHVKPGSLSAE 249
+ +E + +++ GS+GLG SI PI I I + PG ++ +
Sbjct: 682 QSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEK 741
Query: 250 VG-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAA 291
G L GD+++ VN V+ N +EAV LK + S T+ I A
Sbjct: 742 DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVA 784
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/63 (36%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 764 LDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAA 821
L ++ GG SP G + V V+ +GAA G + +GD+I+A+NG+ + T EA A
Sbjct: 1968 LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAI 2027
Query: 822 LQK 824
L++
Sbjct: 2028 LKR 2030
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 10/80 (12%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGC---------GLFISHLIKGGQADSVG-LQVGDEIV 135
+ V L R + LG+S+ GG G G+FI H+++ A G L+ GD IV
Sbjct: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 136 RINGYSISSCTHEEVINLIR 155
++G + +HE+ + IR
Sbjct: 1210 EVDGMDLRDASHEQAVEAIR 1229
Score = 37.7 bits (86), Expect = 0.048
Identities = 53/230 (23%), Positives = 98/230 (42%), Gaps = 35/230 (15%)
Query: 84 KLKEVRLDRLHPEGLGLSVRGGLEFG-CGLFISHLIKGGQADSVG-LQVGDEIVRINGYS 141
+L + L++ H GLGLS+ G + +FI + G A G LQ+ DE++ ING
Sbjct: 1347 ELHMIELEKGH-SGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQI 1405
Query: 142 ISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGS 201
+ +H+ ++I K KV+ I I K + ++ V V +
Sbjct: 1406 LYGRSHQNASSII---KCAPSKVKII-FIRNKDAVNQ--------MAVCPGNAVEPLPSN 1453
Query: 202 PGNRENKEKKVFISLVGSR-------------------GLGCSISSGPIQKPGIFISHVK 242
N +NKE + ++ + GLG +IS I S +
Sbjct: 1454 SENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTE 1513
Query: 243 PGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAA 292
G + + L++GDQI+ V+ ++ +++LK+++ +T+ + A
Sbjct: 1514 HGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAK-MTVKLTIHA 1562
Score = 36.6 bits (83), Expect = 0.11
Identities = 19/80 (23%), Positives = 46/80 (57%), Gaps = 6/80 (7%)
Query: 96 EGLGLSVRGGLEFG----CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEV 150
+GLG+++ G + G+F+ + K + G +Q+GD+I+ ++G ++ T+++
Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 151 INLIR-TKKTVSIKVRHIGL 169
+ ++R T +TV + + G+
Sbjct: 445 VEVLRHTGQTVLLTLMRRGM 464
Score = 35.8 bits (81), Expect = 0.18
Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 751 KDVRLLRIKKE-GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKI 809
K+V+ L + K+ G L +A+ + + V++ ++ E G A G + GD+I+A++ +I
Sbjct: 1479 KNVQHLELPKDQGGLGIAISE--EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
Query: 810 VTDYTLAEAEAALQKA 825
V Y + + + L+ A
Sbjct: 1537 VVGYPIEKFISLLKTA 1552
Score = 33.9 bits (76), Expect = 0.70
Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 11/107 (10%)
Query: 738 DPYSMFTPEQIMGKDVRLLRIKK--EGSLDLALEGGVDSPIGK--VVVSAVYERGAAERH 793
D + G+ V + + K G L ++ G G+ + V + E A R
Sbjct: 120 DEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRD 179
Query: 794 GGIVKGDEIMAINGKIVTDYTLAEAEA--ALQKAWNQGGDWIDLVVA 838
G + + D+I+AING+ + D T+ +A LQKA D + LV+A
Sbjct: 180 GRLKETDQILAINGQAL-DQTITHQQAISILQKA----KDTVQLVIA 221
Score = 33.5 bits (75), Expect = 0.91
Identities = 19/46 (41%), Positives = 30/46 (65%), Gaps = 1/46 (2%)
Query: 779 VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQK 824
V VS + + G A+ G +++GD+I+ +NG+ V + T EA AAL K
Sbjct: 1749 VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEAVAALLK 1793
Score = 32.0 bits (71), Expect = 2.7
Identities = 23/77 (29%), Positives = 39/77 (50%), Gaps = 4/77 (5%)
Query: 753 VRLLRIKK--EGSLDLALEGGVDSPIGKV--VVSAVYERGAAERHGGIVKGDEIMAINGK 808
+R + +KK SL +++ GGV SP+G V ++ ++ G A + + GD I+ I G
Sbjct: 1831 LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 809 IVTDYTLAEAEAALQKA 825
T +A L+ A
Sbjct: 1891 STEGMTHTQAVNLLKNA 1907
Score = 31.2 bits (69), Expect = 4.5
Identities = 17/52 (32%), Positives = 26/52 (50%)
Query: 759 KKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIV 810
K L L+L G D V + + GAA + G + DE++ ING+I+
Sbjct: 1355 KGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Score = 30.8 bits (68), Expect = 5.9
Identities = 15/54 (27%), Positives = 30/54 (55%)
Query: 772 VDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKA 825
+D +++ ++ G AE+ G ++ GD +M +N + + +L EA AL+ A
Sbjct: 721 IDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 70.1 bits (170), Expect = 9e-12
Identities = 54/225 (24%), Positives = 119/225 (52%), Gaps = 9/225 (4%)
Query: 273 EAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLM----QKRLAMESN 328
E V ++ + + +E M + ER+ E R+++++ +E M +K E N
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE-REKKMREEEETMREQEEKMQKQEEN 479
Query: 329 KILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPK 388
QE++E ++QR E +K E+ E+ +++ E+I E+EEK + Q EE WG ++++ +
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQ-EEMWGQEKKMWRQE 537
Query: 389 TITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQK 448
+ + + ++ K + + + KK ++++K + + +R+ ++ E E+K
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK 597
Query: 449 LYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVERL 493
+ +E+E M E+E+ K+ +++ E E + E+ EK+Q E++
Sbjct: 598 MREEEEMMREQEE--KMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
Score = 62.4 bits (150), Expect = 2e-09
Identities = 50/186 (26%), Positives = 100/186 (53%), Gaps = 10/186 (5%)
Query: 300 DRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKE 359
+R R E + RE Q +++ Q++ E K L+EQ E E + +KE+ E+ E+ +++
Sbjct: 300 ERLREQEGKMRE-QEEKMWRQEKRLREQEKELREQ-EKELREQKEL----REQEEQMQEQ 353
Query: 360 MEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIR 419
E++ E+EEK ++Q E+ W +E+L + E +R + W D +
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE-QEQKMRDQEERMW--EQDERLREKE 410
Query: 420 KKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETERED 479
++ ++++K + ++ +R+ KK E E+K ++E+M E+E+ + + +E ET RE
Sbjct: 411 ERMREQEK-MWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ 469
Query: 480 LEESEK 485
E+ +K
Sbjct: 470 EEKMQK 475
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/211 (21%), Positives = 106/211 (50%), Gaps = 21/211 (9%)
Query: 298 MTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEM-ERQRRKEIAQKAAEENERY 356
M ++E +++++ QE M+K+ + K ++++M E +R +E +K EE E
Sbjct: 546 MWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605
Query: 357 RKEMEQIVEEEEKFKKQ----WEED----------WGSKEQLLLPKTITAEVHPVPLRKP 402
R++ E++ E+EEK ++Q WE++ W +E++ + E +P +K
Sbjct: 606 REQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKE 665
Query: 403 KSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQ 462
K + ++ + + +++K + ++ + +++ ++Q+ +E+E M E+EK
Sbjct: 666 K----LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK- 720
Query: 463 LKINRLAQEVSETEREDLEESEKIQYWVERL 493
K+ + + E E + E+ EK+Q E +
Sbjct: 721 -KMREEEEMMREQEEKMQEQEEKMQEQEEEM 750
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/233 (20%), Positives = 117/233 (50%), Gaps = 20/233 (8%)
Query: 298 MTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYR 357
M ++E++ E ++ ++++ M+K+ + K +++ E + +E +K EE E R
Sbjct: 673 MQEQEKMQEQEEKIWEQEK--MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 358 KEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFY---RYDGK 414
++ E++ E+EEK ++Q EE W +E++ + E +P +K K W + + K
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL--WEHEKMQEQEK 788
Query: 415 FPTIRKKGKDKKKAKYGSLQDLRKNKKELE-FEQKLYKEKEEMLEKEKQL---------K 464
+K +D+++ G + +R ++++ E+K++ ++E+M +E+++ +
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848
Query: 465 INRLAQEVSETEREDLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPP 517
++ +++ E + E+ EK++ E++ R ++ E G PP
Sbjct: 849 EEKMEEKMQGQEEKMREQEEKMRGQEEKM---REQEEKMRGQEEKIYCVGSPP 898
Score = 55.1 bits (131), Expect = 3e-07
Identities = 47/194 (24%), Positives = 100/194 (51%), Gaps = 19/194 (9%)
Query: 302 ERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMER-QRRKEIAQKAAEENERYRKEM 360
ERL E +R ++ QE + ++ M K +QEQ++ R Q K ++ E E+ +E
Sbjct: 404 ERLREKEER-MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 361 EQIV-EEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGW----FYRYDGKF 415
E+ + E+EEK +KQ E W +E+ E L + K W + K
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEK---------EWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 416 PTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQL--KINRLAQEVS 473
+K +D+++ +G + + + +K E E ++++++E+M ++E+++ + R+ ++
Sbjct: 514 WEQEEKIRDQEE-MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572
Query: 474 ETEREDLEESEKIQ 487
E E++ ++ EK++
Sbjct: 573 EQEKKTWDQEEKMR 586
Score = 48.1 bits (113), Expect = 4e-05
Identities = 48/191 (25%), Positives = 100/191 (52%), Gaps = 28/191 (14%)
Query: 304 LAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQI 363
LAE+ + E+Q ++++L E K L Q Q + E +R+E E++
Sbjct: 236 LAESEKSEIQLNVKELKRKL--ERAKFLLPQ-----------VQTNTLQEEMWRQE-EEL 281
Query: 364 VEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGK 423
E+E+K +KQ E+ W +E+L + E R+ K R + +R++ K
Sbjct: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK------RLREQEKELREQEK 335
Query: 424 DKKKAKYGSLQDLRKNKKEL-EFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEE 482
+ ++ K +LR+ ++++ E E+K+++++E+M E+E+ K+ R + + E E++ E+
Sbjct: 336 ELREQK-----ELREQEEQMQEQEEKMWEQEEKMREQEE--KMWRQEERLWEQEKQMREQ 388
Query: 483 SEKIQYWVERL 493
+K++ ER+
Sbjct: 389 EQKMRDQEERM 399
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/205 (23%), Positives = 100/205 (48%), Gaps = 38/205 (18%)
Query: 311 ELQRQELLMQKRLAM---ESNKILQEQQEMER--QRRKEI---AQKAAEENERYRKEMEQ 362
EL+++ +Q++L + E ++I +E++R +R K + Q + E +R+E E+
Sbjct: 222 ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE-EE 280
Query: 363 IVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKG 422
+ E+E+K +KQ E+ W +E+L +GK +K
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLR------------------------EQEGKMREQEEKM 316
Query: 423 KDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEE 482
++K ++LR+ +KEL +++L +++E+M E+E+++ QE E+E+
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM----WEQEEKMREQEEKMW 372
Query: 483 SEKIQYWVERLCQTRLEQISSADNE 507
++ + W E+ Q R ++ D E
Sbjct: 373 RQEERLW-EQEKQMREQEQKMRDQE 396
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 67.0 bits (162), Expect = 7e-11
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)
Query: 79 PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137
P R R + VR + +G G + G E G G FI + G A++ L+ GD +V +
Sbjct: 6 PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
Query: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176
NG ++ TH +V+ I R + T + ++ GL P
Sbjct: 60 NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
Query: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234
+ W + SE+G V G L RE + + + G +G G ++ S +P
Sbjct: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
Query: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
G +I V PGS +A GL D+++EVNG + L H E V +K+
Sbjct: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
G +G G + G + G FI V+PGS + L GD++VEVNGV+ H + V
Sbjct: 17 GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
Query: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323
+K+ T L + D+E E R+R+L E + Q+ L
Sbjct: 76 IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
Score = 33.9 bits (76), Expect = 0.70
Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 82 SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137
S L+E+R H P+G G ++ + G +I + G A GL+ D ++ +
Sbjct: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
Query: 138 NGYSISSCTHEEVINLIRTKK 158
NG ++ H EV+ I+ ++
Sbjct: 200 NGQNVEGLRHAEVVASIKARE 220
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 67.0 bits (162), Expect = 7e-11
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)
Query: 79 PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137
P R R + VR + +G G + G E G G FI + G A++ L+ GD +V +
Sbjct: 6 PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
Query: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176
NG ++ TH +V+ I R + T + ++ GL P
Sbjct: 60 NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
Query: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234
+ W + SE+G V G L RE + + + G +G G ++ S +P
Sbjct: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
Query: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
G +I V PGS +A GL D+++EVNG + L H E V +K+
Sbjct: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
G +G G + G + G FI V+PGS + L GD++VEVNGV+ H + V
Sbjct: 17 GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
Query: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323
+K+ T L + D+E E R+R+L E + Q+ L
Sbjct: 76 IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
Score = 33.9 bits (76), Expect = 0.70
Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 82 SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137
S L+E+R H P+G G ++ + G +I + G A GL+ D ++ +
Sbjct: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
Query: 138 NGYSISSCTHEEVINLIRTKK 158
NG ++ H EV+ I+ ++
Sbjct: 200 NGQNVEGLRHAEVVASIKARE 220
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 66.6 bits (161), Expect = 1e-10
Identities = 88/363 (24%), Positives = 148/363 (40%), Gaps = 95/363 (26%)
Query: 334 QQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAE 393
Q+E+E QRR+ Q+ +E ER R E E++ E E +++ E + +E+L
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERM-ERERLERERLERERLERERL--------- 186
Query: 394 VHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEK 453
+ + ++ +++++ + Q+ + ++ LE +++L +E+
Sbjct: 187 --------------------EQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 454 EEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVERLC---------QTRLEQI--S 502
+E E+E+ + RL +E E ER++ E E++++ ER +T L +
Sbjct: 227 QERQERER---LERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
Query: 503 SADNEISEMTTGPPPPPPS-----VSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKT 557
S+ +E P PS + PLAPP PL PP
Sbjct: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPP---------------PPPPL-----PPGP 323
Query: 558 PSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVP----- 612
A +P PPP PP PP LP +G P + PP P PPPP+ P
Sbjct: 324 AQASVALP-PPPGPPP-----PPPLPSTGPPPPPPPPPLPNQVPPPP-PPPPAPPLPASG 376
Query: 613 ------TQDLTPTRPLPSALEEALSNHPFRTGDTGNP-------VEDWEAKNHSGKPTNS 659
++D P L +A+ A R DT P V +K +G+ N
Sbjct: 377 FFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGR-GNG 435
Query: 660 PVP 662
P+P
Sbjct: 436 PLP 438
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 2/86 (2%)
Query: 300 DRERLAEAR-QRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRK 358
+RERL R +RE QE L ++R E + L+ Q+ +ERQ R E Q+ + + R+
Sbjct: 172 ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLE-RQERLDRERQERQ 230
Query: 359 EMEQIVEEEEKFKKQWEEDWGSKEQL 384
E E++ E + +++ ++ +EQL
Sbjct: 231 ERERLERLERERQERERQEQLEREQL 256
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/78 (33%), Positives = 40/78 (51%), Gaps = 8/78 (10%)
Query: 300 DRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKE 359
+RER RQ L+RQE RL + QE+ + ERQ R+E + E ER +E
Sbjct: 192 ERERQERERQERLERQE-----RLERQERLERQERLDRERQERQERERLERLERERQERE 246
Query: 360 MEQIVEEEEKFKKQWEED 377
++ +E E+ +WE +
Sbjct: 247 RQEQLEREQ---LEWERE 261
Score = 35.8 bits (81), Expect = 0.18
Identities = 27/80 (33%), Positives = 45/80 (56%), Gaps = 5/80 (6%)
Query: 300 DRERLAEAR-QRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRK 358
+RERL R +RE +E L Q++L E + + Q+ +ERQ R E Q+ E ER +
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQE-RERQERLERQERLE-RQERLERQERLDR 224
Query: 359 EMEQIVEEE--EKFKKQWEE 376
E ++ E E E+ +++ +E
Sbjct: 225 ERQERQERERLERLERERQE 244
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 66.6 bits (161), Expect = 1e-10
Identities = 88/363 (24%), Positives = 148/363 (40%), Gaps = 95/363 (26%)
Query: 334 QQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAE 393
Q+E+E QRR+ Q+ +E ER R E E++ E E +++ E + +E+L
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERM-ERERLERERLERERLERERL--------- 186
Query: 394 VHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEK 453
+ + ++ +++++ + Q+ + ++ LE +++L +E+
Sbjct: 187 --------------------EQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 454 EEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVERLC---------QTRLEQI--S 502
+E E+E+ + RL +E E ER++ E E++++ ER +T L +
Sbjct: 227 QERQERER---LERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
Query: 503 SADNEISEMTTGPPPPPPS-----VSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKT 557
S+ +E P PS + PLAPP PL PP
Sbjct: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPP---------------PPPPL-----PPGP 323
Query: 558 PSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVP----- 612
A +P PPP PP PP LP +G P + PP P PPPP+ P
Sbjct: 324 AQASVALP-PPPGPPP-----PPPLPSTGPPPPPPPPPLPNQVPPPP-PPPPAPPLPASG 376
Query: 613 ------TQDLTPTRPLPSALEEALSNHPFRTGDTGNP-------VEDWEAKNHSGKPTNS 659
++D P L +A+ A R DT P V +K +G+ N
Sbjct: 377 FFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGR-GNG 435
Query: 660 PVP 662
P+P
Sbjct: 436 PLP 438
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 2/86 (2%)
Query: 300 DRERLAEAR-QRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRK 358
+RERL R +RE QE L ++R E + L+ Q+ +ERQ R E Q+ + + R+
Sbjct: 172 ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLE-RQERLDRERQERQ 230
Query: 359 EMEQIVEEEEKFKKQWEEDWGSKEQL 384
E E++ E + +++ ++ +EQL
Sbjct: 231 ERERLERLERERQERERQEQLEREQL 256
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/78 (33%), Positives = 40/78 (51%), Gaps = 8/78 (10%)
Query: 300 DRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKE 359
+RER RQ L+RQE RL + QE+ + ERQ R+E + E ER +E
Sbjct: 192 ERERQERERQERLERQE-----RLERQERLERQERLDRERQERQERERLERLERERQERE 246
Query: 360 MEQIVEEEEKFKKQWEED 377
++ +E E+ +WE +
Sbjct: 247 RQEQLEREQ---LEWERE 261
Score = 35.8 bits (81), Expect = 0.18
Identities = 27/80 (33%), Positives = 45/80 (56%), Gaps = 5/80 (6%)
Query: 300 DRERLAEAR-QRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRK 358
+RERL R +RE +E L Q++L E + + Q+ +ERQ R E Q+ E ER +
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQE-RERQERLERQERLE-RQERLERQERLDR 224
Query: 359 EMEQIVEEE--EKFKKQWEE 376
E ++ E E E+ +++ +E
Sbjct: 225 ERQERQERERLERLERERQE 244
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/224 (22%), Positives = 117/224 (52%), Gaps = 27/224 (12%)
Query: 300 DRERLAEARQRELQRQELLMQK-RLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRK 358
+ E++ E +R+ Q ++ Q+ ++ + KI +++++M RQ K Q+ E E+ R+
Sbjct: 401 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK-RQ 459
Query: 359 EMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTI 418
E E++ +EEK ++Q EE W KE++ + I RK + W R + K
Sbjct: 460 EQEEMWRQEEKIREQ-EEIWRQKEKMHEQEKI---------RKQEEKVW--RQEEKMHDQ 507
Query: 419 RKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEK------------EKQLKIN 466
+K +++++ + + +R+ ++++ +++ +E+EEM+++ ++Q K+
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 467 RLAQEVSETEREDLEESEKIQYWVERLCQTRLEQISSADNEISE 510
R +++ E E + E+ EKI+ E++ + E+I + + E
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQE-EKIREQEEMMQE 610
Score = 56.2 bits (134), Expect = 1e-07
Identities = 43/208 (20%), Positives = 110/208 (52%), Gaps = 12/208 (5%)
Query: 294 RELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRK--EIAQKAAE 351
+E E++ E + Q++++ Q+++ + K+ +++++M Q K E +K
Sbjct: 461 QEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWR 520
Query: 352 ENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRY 411
+ E+ R++ E+I E+EEK ++Q E +E++ + E + ++ K
Sbjct: 521 QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK----IREQ 576
Query: 412 DGKFPTIRKKGKDKKKAKYGSLQDLRKNKKEL-EFEQKLYKEKEEMLEKEKQL-----KI 465
+ K ++K +++++ + + +R+ ++ + E E+K+++++E+M E+E+++ K+
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 636
Query: 466 NRLAQEVSETEREDLEESEKIQYWVERL 493
R +++ E E ++ EK+Q E L
Sbjct: 637 RRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/206 (22%), Positives = 97/206 (47%), Gaps = 28/206 (13%)
Query: 293 GRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEM---ERQRRKEIAQKA 349
G+EL + A+ + EL + Q+ + +QE +E + ++ +E +K
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 350 AEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFY 409
E+ E+ R++ E + E+EEK ++Q E W +E+ +R+ + W
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK---------------MRRLEEMMW-- 373
Query: 410 RYDGKFPTIRKKGKDKKK-----AKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLK 464
+ K + +K +++K K + +R+ +K E E K+++++E++ E+E++++
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 465 INR---LAQEVSETEREDLEESEKIQ 487
QE E+E + E EK Q
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQ 459
Score = 37.4 bits (85), Expect = 0.063
Identities = 42/194 (21%), Positives = 85/194 (43%), Gaps = 53/194 (27%)
Query: 309 QRELQRQELLM-QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENE---RYRKEMEQIV 364
+R+L+R +LL+ Q++L E++ + +E Q + + + ++ EENE R ++ E+ +
Sbjct: 248 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV-----EENELWNRLNQQQEEKM 302
Query: 365 EEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKD 424
+E+ ++WEE +E+ + + +R+ + W
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW----------------- 345
Query: 425 KKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETE------RE 478
E E+K+ +++E M EKE+ K+ RL + + E E E
Sbjct: 346 -------------------EKEEKMRRQEEMMWEKEE--KMRRLEEMMWEKEEKIRELEE 384
Query: 479 DLEESEKIQYWVER 492
+ E EKI+ E+
Sbjct: 385 KMHEQEKIREQEEK 398
Score = 31.6 bits (70), Expect = 3.5
Identities = 33/123 (26%), Positives = 42/123 (34%), Gaps = 30/123 (24%)
Query: 567 PPPSNPPHK-VPAPPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVPTQDLTPTRPLPS- 624
P P P H +P P LP H+ P +P P +PT PT P+ S
Sbjct: 5 PQPHLPTHPHLPTHPHLPTHPHL-----------PTHPHLPTHPHLPTHPHLPTHPMMSK 53
Query: 625 ---------ALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCP 675
A E+ +HP G D + K K N PE T C
Sbjct: 54 ETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKK----KINNGTNPE----TTTSGGCH 105
Query: 676 SPQ 678
SP+
Sbjct: 106 SPE 108
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 29/230 (12%)
Query: 88 VRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCT 146
V L + GLGLS+ G G G+FIS ++KGG AD G L GD+I+ +NG + + +
Sbjct: 1534 VDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592
Query: 147 HEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVD------------QFVSESGG 194
E V +++ + + IG + S T Q F G
Sbjct: 1593 QETVATILKCAQ--GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITG 1650
Query: 195 VRGSLGS-----PGNREN----KEKKVFISLVGSRGLGCSISSG---PIQKPGIFISHVK 242
++ +G+ P + + + + V I+ S LG SI+ G P+ +FI+ ++
Sbjct: 1651 LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQ 1710
Query: 243 PGSLSAEV-GLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAA 291
++A L++GD+IV +NG L H + VN+LK++ I V A
Sbjct: 1711 ASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
Score = 62.0 bits (149), Expect = 2e-09
Identities = 74/317 (23%), Positives = 133/317 (41%), Gaps = 27/317 (8%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
GLG + GG G+ + ++ GG AD G LQ GD I++I G ++ T E+V ++R
Sbjct: 257 GLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Query: 156 T-KKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESG-GVRGSLGSPGNRENKEKKVF 213
+V + V + +P P V+ G G SL N E K
Sbjct: 315 NCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDG- 373
Query: 214 ISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHK 272
+G R +G +S + GI++ + PGS + G +++ D+IV V+GV+ +
Sbjct: 374 -QSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 273 EAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQ-------ELLMQKRLAM 325
+ V VL++ AG+ + +T R + L+ E L L +
Sbjct: 433 DVVEVLRN-----------AGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFL 481
Query: 326 ESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEE-EEKFKKQWEEDWGSKEQL 384
+ + E + KE +N + +++E++ + E + K +WE G ++
Sbjct: 482 TGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEV 541
Query: 385 LLPKTITAEVHPVPLRK 401
++ T L+K
Sbjct: 542 MVATLDTQIADDAELQK 558
Score = 58.2 bits (139), Expect = 3e-08
Identities = 59/193 (30%), Positives = 83/193 (43%), Gaps = 37/193 (19%)
Query: 97 GLGLSVRGGLEFGCGLFISHLI--KGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLI 154
GLGLS+ GG + + H + +G A L GD+I+ +NG + + +HEE I +
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Query: 155 R-TKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKE-KKV 212
R T + V + V DE Y D+ EN E V
Sbjct: 1506 RQTPQKVRLVVYR----------DEA---HYRDE------------------ENLEIFPV 1534
Query: 213 FISLVGSRGLGCSISSGPIQKPGIFISH-VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDH 271
+ RGLG SI G G+FIS VK G+ + L GDQI+ VNG D N
Sbjct: 1535 DLQKKAGRGLGLSI-VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 272 KEAVNVLKSSRSL 284
+ +LK ++ L
Sbjct: 1594 ETVATILKCAQGL 1606
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 34/147 (23%)
Query: 748 IMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAING 807
+ G+++ + K L L++ GG D+P+ +V+ VYE GAA R G + GD+I+ +NG
Sbjct: 1431 VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNG 1490
Query: 808 KIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELASLPSSVAESPQPVRKLL 867
+ + + EA AL+ ++PQ VR ++
Sbjct: 1491 VDLRNSSHEEAITALR----------------------------------QTPQKVRLVV 1516
Query: 868 EDRAAVHRHGFLLQLEPTDLLLKSKRG 894
A +R L++ P DL K+ RG
Sbjct: 1517 YRDEAHYRDEENLEIFPVDLQKKAGRG 1543
Score = 47.0 bits (110), Expect = 8e-05
Identities = 31/107 (28%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 53 PSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCG- 111
PS P+ ++ L+ K + Q + + V ++R + LG+S+ GG G
Sbjct: 1642 PSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGD 1701
Query: 112 --LFISHLIKGG-QADSVGLQVGDEIVRINGYSISSCTHEEVINLIR 155
+FI+ + G A + L+VGD IV ING + +H +V+NL++
Sbjct: 1702 IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748
Score = 46.6 bits (109), Expect = 1e-04
Identities = 55/211 (26%), Positives = 86/211 (40%), Gaps = 25/211 (11%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGL-QVGDEIVRINGYSISS 144
K +L +H LG+ V F +IS ++ GG D++GL Q DE++ +NG +
Sbjct: 558 KYSKLLPIHTLRLGVEVDS---FDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYG 614
Query: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQY----------VDQFVSESGG 194
+ E ++ ++ V L ++S DEP + +D E
Sbjct: 615 KSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDD 674
Query: 195 VRGSLGSPGNRENKEKKVFISLVGSRGLGCSISS-----GPIQKPGIFISHVKPGSLSAE 249
+L SP E K+ + +GLG SI P + + S V G
Sbjct: 675 GELALWSP------EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERS 728
Query: 250 VGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
GL GD++V VN N EAV +LK+
Sbjct: 729 GGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/77 (37%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Query: 214 ISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHK 272
IS+VG + + + +G K GIFI V S + + L+ GD+I+EV+GVD N H
Sbjct: 1081 ISIVGGQTVIKRLKNGEELK-GIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHS 1139
Query: 273 EAVNVLKSSRSLTISIV 289
EAV +K++ + + IV
Sbjct: 1140 EAVEAIKNAGNPVVFIV 1156
Score = 44.3 bits (103), Expect = 5e-04
Identities = 25/66 (37%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 218 GSRGLGCSISSGPIQKPGIFISH--VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAV 275
G GLG SI G + H + G+ + + L GDQI+EVNGVD N H+EA+
Sbjct: 1443 GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAI 1502
Query: 276 NVLKSS 281
L+ +
Sbjct: 1503 TALRQT 1508
Score = 37.7 bits (86), Expect = 0.048
Identities = 50/234 (21%), Positives = 96/234 (41%), Gaps = 48/234 (20%)
Query: 98 LGLSVRGG------LEFG---CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTH 147
LG+S+ GG L+ G G+FI +++ A L+ GD+I+ ++G + + +H
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 148 EEVINLIRTK-KTVSIKVRHIG----LIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSP 202
E + I+ V V+ + +IP + +T + +G+ P
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
Query: 203 ------------GNRENKEKKVFIS---------LVGS----------RGLGCSISSGPI 231
+ EN+E+ F L G GLG S++
Sbjct: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258
Query: 232 Q-KPGIFISHVKP-GSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRS 283
+ + IF+ + P G +A+ + IGD+++E+N H+ A ++K++ S
Sbjct: 1259 RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
Score = 35.8 bits (81), Expect = 0.18
Identities = 29/102 (28%), Positives = 53/102 (51%), Gaps = 11/102 (10%)
Query: 752 DVRLLRIKKE----GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAING 807
+V+++ + K+ G L + +D +V+ ++ G AER GG++ GD ++++N
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 808 KIVTDYTLAEAEAALQKAWNQGGDWIDLV-VAVCPPKEYDDE 848
+ + +LAEA L KA G LV + +C P D+E
Sbjct: 743 YCLDNTSLAEAVEIL-KAVPPG-----LVHLGICKPLVEDNE 778
Score = 33.9 bits (76), Expect = 0.70
Identities = 23/79 (29%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 754 RLLRIKKEGS--LDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKI 809
R + I +E S L +++ GG SP+G V ++ + G A R + GD I++ING+
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQP 1734
Query: 810 VTDYTLAEAEAALQKAWNQ 828
+ + A+ L+ A+ +
Sbjct: 1735 LDGLSHADVVNLLKNAYGR 1753
Score = 32.3 bits (72), Expect = 2.0
Identities = 25/84 (29%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 745 PEQIMGKDVRLLRIKKEGS-LDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIM 803
PE + V + + +GS L + GG S VVV + G A+R G + GD I+
Sbjct: 238 PETVCWGHVEEVELINDGSGLGFGIVGGKTSG---VVVRTIVPGGLADRDGRLQTGDHIL 294
Query: 804 AINGKIVTDYTLAEAEAALQKAWN 827
I G V T + L+ N
Sbjct: 295 KIGGTNVQGMTSEQVAQVLRNCGN 318
Score = 31.2 bits (69), Expect = 4.5
Identities = 11/30 (36%), Positives = 23/30 (76%)
Query: 779 VVVSAVYERGAAERHGGIVKGDEIMAINGK 808
V +S + + GAA+ G +++GD+I+++NG+
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGE 1586
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/212 (23%), Positives = 114/212 (53%), Gaps = 15/212 (7%)
Query: 300 DRERLAEARQRELQRQELLMQKRLAMESNKILQEQQE-MERQRRKEIAQKAAEENERYRK 358
+ E++ E +R+ Q ++ Q+ E + ++EQ+E M RQ K Q+ E E+ R+
Sbjct: 462 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK-RQ 520
Query: 359 EMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTI 418
E E++ +EEK ++Q EE W KE++ +RK + W R + K
Sbjct: 521 EQEEMWRQEEKIREQ-EEIWRQKEKI--------HEQEEKIRKQEEKMW--RQEEKMHDQ 569
Query: 419 RKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETERE 478
+K +++++ + + +R+ ++++ +++ +E+EEM +++++ K+ +++ E E +
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE-KMGEQEEKMCEQEEK 628
Query: 479 DLEESEKIQYWVERLCQTRLEQISSADNEISE 510
E+ EK++ E++ + + ++I + +I E
Sbjct: 629 MQEQEEKMRRQEEKI-REQEKKIREQEEKIRE 659
Score = 61.2 bits (147), Expect = 4e-09
Identities = 53/218 (24%), Positives = 112/218 (51%), Gaps = 23/218 (10%)
Query: 295 ELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENE 354
E E++ E ++ +++E + ++ E K QEQ+EM RQ K E E
Sbjct: 484 EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK-RQEQEEMWRQEEK------IREQE 536
Query: 355 RYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGK 414
++ E+I E+EEK +KQ E+ W +E++ +R+ + W R + K
Sbjct: 537 EIWRQKEKIHEQEEKIRKQEEKMWRQEEKM--------HDQEEKIREQEEKVW--RQEEK 586
Query: 415 FPTIRKKGKDKKKAKYGSLQDLRKNKKEL--EFEQKLYKEKEEMLEKEKQLKINRLAQEV 472
+K +++++ K +++ + ++E E E+K+ +++E+M E+E+ K+ R +++
Sbjct: 587 IREQEEKIREQEE-KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE--KMRRQEEKI 643
Query: 473 SETEREDLEESEKIQYWVERLCQTRLEQISSADNEISE 510
E E++ E+ EKI+ E + Q + E++ + ++ E
Sbjct: 644 REQEKKIREQEEKIRE-QEEMMQEQEEKMWEQEEKMCE 680
Score = 57.0 bits (136), Expect = 8e-08
Identities = 45/203 (22%), Positives = 97/203 (47%), Gaps = 28/203 (13%)
Query: 293 GRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEM---ERQRRKEIAQKA 349
G+EL + A+ + EL + Q+ + +QE +E + ++ +E +K
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391
Query: 350 AEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFY 409
E+ E+ R++ E + E+EEK ++Q E W +E+ +R+ + W
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK---------------MRRQEEMMW-- 434
Query: 410 RYDGKFPTIRKKGKDKKK-----AKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLK 464
+ K + +K +++K K + +R+ +K E E K+++++E++ E+E+++
Sbjct: 435 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI- 493
Query: 465 INRLAQEVSETEREDLEESEKIQ 487
R +E + E + E EKI+
Sbjct: 494 --REQEEKMWRQEEKIHEQEKIR 514
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/207 (21%), Positives = 105/207 (50%), Gaps = 14/207 (6%)
Query: 301 RERLAEARQRELQRQE--LLMQKRLAMESNKILQEQQEMERQRRKEIAQ--KAAEENERY 356
RE Q E+ RQE + Q+ + + KI ++++++ +Q K Q K ++ E+
Sbjct: 514 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI 573
Query: 357 RKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSF----GWFYRYD 412
R++ E++ +EEK ++Q E+ +E++ + +T E + + +
Sbjct: 574 REQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 633
Query: 413 GKFPTIRKKGKDKKKAKYGSLQDLRKNKKEL-EFEQKLYKEKEEMLEKEKQL-----KIN 466
K +K ++++K + +R+ ++ + E E+K+++++E+M E+E+++ K+
Sbjct: 634 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 693
Query: 467 RLAQEVSETEREDLEESEKIQYWVERL 493
R +++ E E ++ EK+Q E L
Sbjct: 694 RQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 47.8 bits (112), Expect = 5e-05
Identities = 52/223 (23%), Positives = 99/223 (44%), Gaps = 50/223 (22%)
Query: 295 ELFMTDRERLAEARQRELQRQELLMQKRLAMESNKIL-----QEQQEMERQRRK--EIAQ 347
+L + ++ AEA + Q + + + +E N++ Q++++M RQ K E +
Sbjct: 316 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE 375
Query: 348 KAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGW 407
K E+ E+ R++ E+I E+EEK ++Q E W +E++ R+ + W
Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM---------------RRQEEMMW 420
Query: 408 FYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINR 467
K++K R+ + E E+K+ + +E+M E+EK +
Sbjct: 421 --------------EKEEKMR--------RQEEMMWEKEEKIRELEEKMHEQEKIRE--- 455
Query: 468 LAQEVSETEREDLEESEKIQYWVERLCQTRLEQISSADNEISE 510
QE E E + E EK Q ++ + E+I + +I E
Sbjct: 456 --QEEKRQEEEKIREQEKRQEQEAKMWRQE-EKIREQEEKIRE 495
Score = 42.7 bits (99), Expect = 0.002
Identities = 23/89 (25%), Positives = 54/89 (60%), Gaps = 6/89 (6%)
Query: 298 MTDRERLAEARQRELQRQE--LLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENER 355
M ++E + ++ +++RQE + Q++ E + ++EQ+EM +++ +K E+ E+
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE----EKMWEQEEK 677
Query: 356 YRKEMEQIVEEEEKFKKQWEEDWGSKEQL 384
++ E++ E+EEK ++Q E+ W + +L
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKMWEQEVRL 706
Score = 40.0 bits (92), Expect = 0.010
Identities = 22/86 (25%), Positives = 49/86 (56%), Gaps = 9/86 (10%)
Query: 300 DRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRK--EIAQKAAEENERYR 357
++E + + ++ ++ QE +++ + K+ +++++M RQ K E +K E+ E+ R
Sbjct: 603 EQEEMTQEQEEKMGEQE----EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 358 KEMEQIVEEEEKFKKQWEEDWGSKEQ 383
++ E + E+EEK WE++ EQ
Sbjct: 659 EQEEMMQEQEEK---MWEQEEKMCEQ 681
Score = 35.8 bits (81), Expect = 0.18
Identities = 42/200 (21%), Positives = 85/200 (42%), Gaps = 62/200 (31%)
Query: 309 QRELQRQELLM-QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENE---RYRKEMEQIV 364
+R+L+R +LL+ Q++L E++ + +E Q + + + ++ EENE R ++ E+ +
Sbjct: 309 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV-----EENELWNRLNQQQEEKM 363
Query: 365 EEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKD 424
+E+ ++WEE +E+ + + +R+ + W
Sbjct: 364 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW----------------- 406
Query: 425 KKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEK------------EKQLKINRLAQEV 472
E E+K+ +++E M EK EK+ KI L +++
Sbjct: 407 -------------------EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 447
Query: 473 SETER-----EDLEESEKIQ 487
E E+ E +E EKI+
Sbjct: 448 HEQEKIREQEEKRQEEEKIR 467
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 64.7 bits (156), Expect = 4e-10
Identities = 48/213 (22%), Positives = 114/213 (53%), Gaps = 12/213 (5%)
Query: 300 DRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKE 359
+R R E + RE + + +KRL + ++ ++++E+ Q+ K E+ E+ +++
Sbjct: 262 ERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQK------KLREQEEQMQEQ 315
Query: 360 MEQIVEEEEKFKKQWEEDWGSKEQLL-LPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTI 418
E++ E+EEK ++Q E+ W +E+L K + + + ++ + + R K +
Sbjct: 316 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 375
Query: 419 RKKGKD-KKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETER 477
R++ K +++ K + +R+ +K++ E++ +E+EE ++K+++ N QE E ++
Sbjct: 376 REQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE---NMWEQEEKEWQQ 432
Query: 478 EDLEESEKIQYWVERLCQTRLEQISSADNEISE 510
+ L E +K + W + Q + E+I + +I +
Sbjct: 433 QRLPE-QKEKLWEQEKMQEQEEKIWEQEEKIRD 464
Score = 63.2 bits (152), Expect = 1e-09
Identities = 53/210 (25%), Positives = 110/210 (52%), Gaps = 21/210 (10%)
Query: 298 MTDRERLAEARQRELQRQELLM----QKRLAMESNKILQEQQEMERQRRKEIAQKAAEEN 353
M + ER+ E R+++++ +E M +K E N QE++E ++QR E +K E+
Sbjct: 388 MQEEERIRE-REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ- 445
Query: 354 ERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPV-----PLRKPKSFGW- 407
E+ +++ E+I E+EEK + Q EE WG ++++ + + + + +R + W
Sbjct: 446 EKMQEQEEKIWEQEEKIRDQ-EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 504
Query: 408 ----FYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQL 463
+ D + ++ +++KK + + +R+ KK E E+K + ++E+M E+E+
Sbjct: 505 QEERMWEQDERLREKEERMREQKK-MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMR 563
Query: 464 KINRLAQEVSETEREDLEESEKIQYWVERL 493
+ + +E E R E+ EK+Q E++
Sbjct: 564 EREKKMREEEEMMR---EQEEKMQEQEEKM 590
Score = 60.8 bits (146), Expect = 5e-09
Identities = 45/193 (23%), Positives = 104/193 (53%), Gaps = 13/193 (6%)
Query: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
++RL E +++ +++++ Q+ E + +++Q+EM Q +K Q E+ R++
Sbjct: 432 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ------EKMREQE 485
Query: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRK 420
+Q+ E+EEK + Q ++ W +E++ E +R+ K ++ + K K
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE-RMREQKK---MWQQEEKMRE-EK 540
Query: 421 KGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDL 480
K ++++K + + +R+ ++ E E+K+ +E+E M E+E+ K+ +++ E E +
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE--KMQEQEEKMREQEEKMW 598
Query: 481 EESEKIQYWVERL 493
E+ EK+Q E++
Sbjct: 599 EQEEKMQEQEEKM 611
Score = 57.0 bits (136), Expect = 8e-08
Identities = 42/193 (21%), Positives = 100/193 (51%), Gaps = 24/193 (12%)
Query: 302 ERLAEARQRELQRQELLMQKRLAMESNKILQEQQEM-ERQRRKEIAQKAAEENERYRKEM 360
ER+ E ++ Q +++ +K+ + K ++++M E +R +E +K EE E R++
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 580
Query: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRK 420
E++ E+EEK ++Q E+ W +E++ + + + + W +
Sbjct: 581 EKMQEQEEKMREQEEKMWEQEEKM--------QEQEEKMWEQEEKMW-----------EQ 621
Query: 421 KGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDL 480
+ +DK + + + + + +K E E+K+++++E+M E+E+ K+ +++ E +
Sbjct: 622 EEEDKMQEQEEMMWE--QEEKMQEQEEKMWEQEEKMREQEE--KMREQEEKMQGQEEKMR 677
Query: 481 EESEKIQYWVERL 493
E+ EK+Q E++
Sbjct: 678 EQEEKMQGQEEKM 690
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/228 (20%), Positives = 115/228 (50%), Gaps = 29/228 (12%)
Query: 269 LDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLM---QKRLAM 325
L+ KE L+ ++ L + +E E L E +++++++QE M ++RL
Sbjct: 208 LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE-QEKKIRKQEEKMWRQEERLRE 266
Query: 326 ESNKILQEQQEMERQR---RKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKE 382
+ K+ +++++M +R R +K E E+ +E +++ E+EE+ ++Q E+ W +E
Sbjct: 267 QEGKMREQEEKM--RRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE 324
Query: 383 QLLLPKTITAEVHPVPLRKPKSFGW-----FYRYDGKFPTIRKKGKDKKKAKYGSLQDLR 437
+ +R+ + W + + + +K +D+++ + + LR
Sbjct: 325 K---------------MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 369
Query: 438 KNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEK 485
+ ++ + ++K+++++E+M E+E+ + + +E ET RE E+ +K
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQK 417
Score = 50.8 bits (120), Expect = 6e-06
Identities = 47/201 (23%), Positives = 99/201 (49%), Gaps = 36/201 (17%)
Query: 298 MTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYR 357
+ ++ RLAE+ + E+Q ++++L E K L Q Q + E +R
Sbjct: 192 LQEKLRLAESEKSEIQLNVKELKRKL--ERAKFLLPQ-----------VQTNTLQEEMWR 238
Query: 358 KEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGKFPT 417
+E E++ E+E+K +KQ E+ W +E+L + G + K
Sbjct: 239 QE-EELREQEKKIRKQEEKMWRQEERL-----------------REQEGKMREQEEKMRR 280
Query: 418 IRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQL-----KINRLAQEV 472
K+ ++++K ++LR+ KK E E+++ +++E+M E+E+++ K+ R + +
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 340
Query: 473 SETEREDLEESEKIQYWVERL 493
E E++ E+ +K++ ER+
Sbjct: 341 WEQEKQMREQEQKMRDQEERM 361
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/235 (18%), Positives = 117/235 (49%), Gaps = 21/235 (8%)
Query: 298 MTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYR 357
M + ++ E ++ ++E + ++ E K ++E++EM R++ +K E+ E+ R
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE----EKMQEQEEKMR 591
Query: 358 KEMEQIVEEEEKFK----KQWEED---WGSKEQLLL---PKTITAEVHPVPLRKPKSFGW 407
++ E++ E+EEK + K WE++ W +E+ + + + + + ++ K
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK---- 647
Query: 408 FYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINR 467
+ + K +K +++++ G + +R+ +++++ +++ +E+EE + +++ +
Sbjct: 648 MWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ 707
Query: 468 LAQEVSETEREDLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSV 522
+E + E + E+++ ER+ + + E++ E E + P PP V
Sbjct: 708 --EEKMWGQEEKMWGQEEMREKEERI-RDQKEKMQERLPEHEERCSEPCLPPSKV 759
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/192 (22%), Positives = 92/192 (47%), Gaps = 11/192 (5%)
Query: 302 ERLAEARQRELQRQELLMQKRLAMESNKILQEQQE--MERQRRKEIAQKAAEENERYRKE 359
+++ + +R ++ E L +K M + + EQ+E E +R +E +K EE E R++
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Query: 360 MEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGW----FYRYDGKF 415
E++ ++EE WE++ +Q LP+ +++ + W R +
Sbjct: 412 EEKMQKQEEN---MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468
Query: 416 PTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQL--KINRLAQEVS 473
KK ++K + Q + +K + EQK++ ++E M E++++L K R+ ++
Sbjct: 469 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKK 528
Query: 474 ETEREDLEESEK 485
++E+ EK
Sbjct: 529 MWQQEEKMREEK 540
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/194 (18%), Positives = 96/194 (49%), Gaps = 29/194 (14%)
Query: 295 ELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENE 354
E+ E++ E ++ +++E + + + K+ +++++M Q K Q EE +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWE-----QEEKMQEQEEKMWEQEEKMWEQ---EEED 625
Query: 355 RYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGK 414
+ +++ E + E+EEK ++Q E+ W +E++ + E + K
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMRE-----------------QEEK 668
Query: 415 FPTIRKKGKDKKKAKYGSLQDLRKNKKELE-FEQKLYKEKEEMLEKEKQLKINRLAQEVS 473
+K +++++ G + +R+ ++++ E+K++ ++E+M +E+++ +E+
Sbjct: 669 MQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ---EEMR 725
Query: 474 ETEREDLEESEKIQ 487
E E ++ EK+Q
Sbjct: 726 EKEERIRDQKEKMQ 739
Score = 38.9 bits (89), Expect = 0.022
Identities = 41/204 (20%), Positives = 99/204 (48%), Gaps = 19/204 (9%)
Query: 306 EARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRK--EIAQKAAEENERYRK----- 358
E + RE + + ++RL + ++ +++Q+M Q + E ++ E+ ER R+
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 359 EMEQIVEEEEKF----KKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYDGK 414
E E+ ++EEE+ KK EE+ +EQ + + + + ++ K + + K
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMREQ---EEKMQKQEENMWEQEEKEWQQQRLPEQK 439
Query: 415 FPTIRKKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQL-----KINRLA 469
++ +++ K ++ ++++E+ ++K +E+M E+E Q+ K+
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499
Query: 470 QEVSETEREDLEESEKIQYWVERL 493
Q++ + E E+ E+++ ER+
Sbjct: 500 QKMWDQEERMWEQDERLREKEERM 523
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 63.5 bits (153), Expect = 8e-10
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 34/228 (14%)
Query: 95 PEGLGLSVRGGLEFG-CGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINL 153
P G G + G E G G +I + G A+ GL GD +V +NG ++ TH++V++
Sbjct: 21 PNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
Query: 154 IRTK-----------------KTVSIKVRHIGLIPVKSSPD--EPLTWQYVDQFVSESGG 194
IR + + ++VR L+ + +P EP V +E+
Sbjct: 79 IRAALNAVRLLVVDPETDEQLQKLGVQVRE-ELLRAQEAPGQAEPPAAAEVQGAGNENEP 137
Query: 195 VRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEI 254
P RE + + + G G G ++ S KPG FI V P S + GL
Sbjct: 138 READKSHPEQRELRPRLCTMKK-GPSGYGFNLHSDK-SKPGQFIRSVDPDSPAEASGLRA 195
Query: 255 GDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRE 302
D+IVEVNGV H + V+ +++ T +L + DRE
Sbjct: 196 QDRIVEVNGVCMEGKQHGDVVSAIRAGGDET---------KLLVVDRE 234
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 63.2 bits (152), Expect = 1e-09
Identities = 70/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)
Query: 96 EGLGLSVRGGLE--FG-CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVI 151
+GLG S+ GG + +G G+++ + GG A + G LQ GDEI+ +NG S++ TH++ +
Sbjct: 225 KGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDAL 284
Query: 152 NLIRTKK----TVSIKVR---------HIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGS 198
+ K T++++ R H+ +S + F ES S
Sbjct: 285 QKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIS 344
Query: 199 LGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQK--PGIFISHVKPGSLSAEVG-LEIG 255
P R E V + GLG + S P + GIF+ + PGS++ G L G
Sbjct: 345 TAKPNYRIMVE--VSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCG 402
Query: 256 DQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQ 315
D+IVE++ L E +L + I+ + + +++ ++L EA + ++
Sbjct: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE-QQLKEAVAQAVENT 461
Query: 316 ELLMQK-RLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
+ ++ + ++E K L+ KE + +A + R +K M
Sbjct: 462 KFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVM 507
Score = 50.8 bits (120), Expect = 6e-06
Identities = 53/219 (24%), Positives = 98/219 (44%), Gaps = 21/219 (9%)
Query: 83 RKLKEVRLDRLHPE---GLGLSVRGGLEFGCGLFISHLI-KGGQADSVG-LQVGDEIVRI 137
++L + + LH E GLG S+ GG + + H + G A G +Q G+E++ I
Sbjct: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
Query: 138 NGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRG 197
NG S+ TH + + ++R + + R ++ K +P+ D S
Sbjct: 1166 NGKSLKGTTHHDALAILRQAR----EPRQAVIVTRKLTPE-----AMPDLNSSTDSAASA 1216
Query: 198 SLGSPGNRENKEKKVFISLV---GSRGLGCSISSGPIQKPG---IFISHVKPGSLSAE-V 250
S S + E+ + ++ S GLG S+ G G + I+ + G+ S +
Sbjct: 1217 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
Query: 251 GLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
++ GD+I+++ G L EA N++K+ ++IV
Sbjct: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIV 1315
Score = 48.1 bits (113), Expect = 4e-05
Identities = 30/98 (30%), Positives = 50/98 (51%)
Query: 728 QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER 787
++ +K E T +Q+ G V +L ++ L +L GG D + V V+
Sbjct: 1088 EELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPN 1147
Query: 788 GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKA 825
G A + G I KG+E+++INGK + T +A A L++A
Sbjct: 1148 GLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185
Score = 42.0 bits (97), Expect = 0.003
Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 15/108 (13%)
Query: 187 QFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGP--IQKP-GIFISHVKP 243
Q V SGG++ S+ S + + ++GLG SI G I P GI++ +
Sbjct: 201 QLVQPSGGLQASVIS---------NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFA 251
Query: 244 GSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRS--LTISI 288
G +A G L+ GD+I+E+NG + L H++A+ K ++ LT+++
Sbjct: 252 GGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTV 299
Score = 36.2 bits (82), Expect = 0.14
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Query: 764 LDLALEGGVDS---PIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEA 820
L ++ GG DS PIG + V ++ GAA G + +GDEI+ +NG+ + T +A
Sbjct: 227 LGFSIVGGKDSIYGPIG-IYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
Query: 821 ALQKA 825
++A
Sbjct: 286 KFKQA 290
Score = 30.4 bits (67), Expect = 7.7
Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 759 KKEGSLDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLA 816
K L +LEGG S G + ++ +++ A+E+ + GDEI+ + G + T
Sbjct: 1239 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 1298
Query: 817 EA 818
EA
Sbjct: 1299 EA 1300
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 62.8 bits (151), Expect = 1e-09
Identities = 61/188 (32%), Positives = 72/188 (38%), Gaps = 18/188 (9%)
Query: 509 SEMTTGPPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIP----LDMFYYPPKTPSALPVM 564
+EM PPPP P PP AG L L IP L PP P +
Sbjct: 905 TEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGI 964
Query: 565 PHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQ-RTPPPIP---IPPPPSVPTQDLTPTR 620
P PPP P +P PP LP +G P PPP+P IPPPP +P + P
Sbjct: 965 PLPPPL-PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1023
Query: 621 PLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPK---TFCPSP 677
PLP A + P G P +G P P+P PP P P P
Sbjct: 1024 PLPGA---GIPPPPPLPGAGIPPPPPLPG---AGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077
Query: 678 QPPRGPGV 685
P G G+
Sbjct: 1078 PPLPGAGI 1085
Score = 61.6 bits (148), Expect = 3e-09
Identities = 63/204 (30%), Positives = 78/204 (38%), Gaps = 26/204 (12%)
Query: 514 GPPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSA-LPVMPHPPPSNP 572
G PPPPP PP G L + + PP P A +P PPP P
Sbjct: 1073 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP---PPPLPGAGIP----PPPPLP 1125
Query: 573 PHKVPAPPVLPLSGHVSASSSPWVQ-RTPPPIP---IPPPPSVPTQDLTPTRPLPSALEE 628
+P PP LP +G P V PPP+P IPPPP +P + P PLP
Sbjct: 1126 GAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV--- 1182
Query: 629 ALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQPPRGPGVSTI 688
+ P G P +G P P+P PP P P PP G G+
Sbjct: 1183 GIPPPPPLPGVGIPPPPPLPG---AGIPPPPPLPGMGIPPAP----APPLPPPGTGIP-- 1233
Query: 689 SKPVMVHQEPNFIYRPAVKSEVLP 712
P++ P + P V S LP
Sbjct: 1234 PPPLLPVSGPPLL--PQVGSSTLP 1255
Score = 59.7 bits (143), Expect = 1e-08
Identities = 53/178 (29%), Positives = 66/178 (37%), Gaps = 31/178 (17%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPH 574
PPPPP + + PP G+ PL PP P +P PPP P
Sbjct: 1020 PPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPGAGIPPPPPL-PGA 1072
Query: 575 KVPAPPVLPLSGHVSASSSPWVQRTPPP----IPIPPPPSVPTQDLTPTRPLPSALEEAL 630
+P PP LP +G P PPP + IPPPP +P + P PLP A +
Sbjct: 1073 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGA---GI 1129
Query: 631 SNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPK---TFCPSPQPPRGPGV 685
P G +G P P+P PP P P P P G G+
Sbjct: 1130 PPPPPLPG--------------AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGI 1173
Score = 57.8 bits (138), Expect = 5e-08
Identities = 54/184 (29%), Positives = 66/184 (35%), Gaps = 31/184 (16%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPH 574
PPPPP + + PP G+ PL PP P +P PPP P
Sbjct: 1064 PPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPGVGIPPPPPL-PGA 1116
Query: 575 KVPAPPVLPLSGHVSASSSPWVQRTPPP----IPIPPPPSVPTQDLTPTRPLPSALEEAL 630
+P PP LP +G P PPP + IPPPP +P + P PLP A +
Sbjct: 1117 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGA---GI 1173
Query: 631 SNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPK---TFCPSPQPPRGPGVST 687
P G G P P+P PP P P P P G G+
Sbjct: 1174 PPPPPLPG--------------VGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPP 1219
Query: 688 ISKP 691
P
Sbjct: 1220 APAP 1223
Score = 57.0 bits (136), Expect = 8e-08
Identities = 51/177 (28%), Positives = 63/177 (35%), Gaps = 40/177 (22%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPH 574
PPPPPP P L A IP P ++P PPP P
Sbjct: 877 PPPPPPLPGMTVPTLPSTA------------IP------QPPPLQGTEMLPPPPPPLPGA 918
Query: 575 KVPAPPVLPLSGHVSASSSPWVQRTPPPIP---IPPPPSVPTQDLTPTRPLPSALEEALS 631
+P PP LP +G + PP+P IPPPP +P + P PLP A
Sbjct: 919 GIPPPPPLPGAGILPL----------PPLPGAGIPPPPPLPGAAIPPPPPLPGA------ 962
Query: 632 NHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPK---TFCPSPQPPRGPGV 685
P G + +G P P+P PP P P P P G G+
Sbjct: 963 GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1019
Score = 52.4 bits (124), Expect = 2e-06
Identities = 54/205 (26%), Positives = 74/205 (36%), Gaps = 30/205 (14%)
Query: 505 DNEISEMTTGPPPPPPSV-------SPLAPPLRRFAGGL---HLHTTDLDDIPLDMFYYP 554
D+ + PPPPPS+ P + P + H H+ P
Sbjct: 799 DSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSP 858
Query: 555 PKTP-----SALP---VMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIP-- 604
P P S++P ++P PPP P VP P + + + PPP+P
Sbjct: 859 PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918
Query: 605 -IPPPPSVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPE 663
IPPPP +P + P PLP A + P G P +G P P+P
Sbjct: 919 GIPPPPPLPGAGILPLPPLPGA---GIPPPPPLPGAAIPPPPPLPG---AGIPLPPPLPG 972
Query: 664 QSFPPTPK---TFCPSPQPPRGPGV 685
PP P P P P G G+
Sbjct: 973 AGIPPPPPLPGAGIPPPPPLPGAGI 997
Score = 43.9 bits (102), Expect = 7e-04
Identities = 58/215 (26%), Positives = 74/215 (34%), Gaps = 47/215 (21%)
Query: 514 GPPPPPPSVSPLAPPLRRFAGGLHLHTT------DLDDI-PLDMFYYPPKTPSAL-PVMP 565
G PP PP + P +F + L + LD P PP PS L
Sbjct: 765 GRPPCPPGAE--SGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQ 822
Query: 566 HPPPSNPPHKV----------------------PAPPVLPLSGHVSASSSPWVQRTPPPI 603
P S PPH + P+PP LP + S+SS P + PPP
Sbjct: 823 GQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTE--SSSSMPGLGMVPPPP 880
Query: 604 PIPPPPSVPTQDLTP-TRPLPSALEEALSNHPFRTGDTGNP---------VEDWEAKNHS 653
P P +VPT T +P P E L P G P + +
Sbjct: 881 PPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGA 940
Query: 654 GKPTNSPVPEQSFPPTPK---TFCPSPQPPRGPGV 685
G P P+P + PP P P P P G G+
Sbjct: 941 GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975
>gi|146134388 YLP motif containing 1 [Homo sapiens]
Length = 2146
Score = 62.4 bits (150), Expect = 2e-09
Identities = 77/320 (24%), Positives = 124/320 (38%), Gaps = 45/320 (14%)
Query: 441 KELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVERLCQTRL-E 499
+ E +Q+ ++ + E+E QL +L + + ++ E+ K + Q+ L E
Sbjct: 439 RHYEMQQQQFQHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQSYLQE 498
Query: 500 QISSADNEISEMTTGPPPPPPSV--SPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKT 557
+++S N ++ PPP V S + PPL + L PP
Sbjct: 499 KVNSFQNMKNQYMGNMSMPPPFVPYSQMPPPLPTMPPPV-----------LPPSLPPPVM 547
Query: 558 PSALPVMPHPPPSNPPHKVPA------PPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSV 611
P ALP PP PP P+ PP +P S +S++ P V P PPP +
Sbjct: 548 PPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPS--LSSAGPPPVLPPPSLSSAGPPPVL 605
Query: 612 PTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPK 671
P L+ T P P LS+ T G P G P P + P P
Sbjct: 606 PPPSLSSTAPPPVMPLPPLSS---ATPPPGIP--------PPGVPQGIPPQLTAAPVPPA 654
Query: 672 TFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFR 731
+ S Q P P + + PV P Y P ++S +++ + + ++A
Sbjct: 655 SSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHPPLQSAGPSEQVNSKAPLSKSAL----- 709
Query: 732 KYEEGFDPYSMFTPEQIMGK 751
PYS F+ +Q +G+
Sbjct: 710 -------PYSSFSSDQGLGE 722
Score = 60.8 bits (146), Expect = 5e-09
Identities = 61/248 (24%), Positives = 94/248 (37%), Gaps = 49/248 (19%)
Query: 516 PPPPP--------------SVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSAL 561
PPPPP S +P AP F H L + +
Sbjct: 20 PPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQ-----QMHQKQMQC 74
Query: 562 PVMPH--PPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVPTQDLTPT 619
+ PH PPP PP PPV+P G+ W Q PPP+P PP P++ Q
Sbjct: 75 VLQPHHLPPPPLPP-----PPVMPGGGY-----GDW-QPPPPPMPPPPGPALSYQK---- 119
Query: 620 RPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQP 679
+ + +H R G G + E+ P + PVP S+ P +++ P PQP
Sbjct: 120 ---QQQYKHQMLHHQ-RDGPPGLVPMELESP-----PESPPVPPGSYMPPSQSYMPPPQP 170
Query: 680 PRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGFDP 739
P T S+P + +P+ P +S + P ++ Q + + + + P
Sbjct: 171 PPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSS----SSSSSQSYLSHSQSYLP 226
Query: 740 YSMFTPEQ 747
S +P +
Sbjct: 227 SSQASPSR 234
Score = 46.6 bits (109), Expect = 1e-04
Identities = 46/154 (29%), Positives = 61/154 (39%), Gaps = 23/154 (14%)
Query: 553 YPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIP-IPPPPSV 611
YPP P + P PP PP + P P V + P PPP P +PPPP V
Sbjct: 1506 YPP--PGSY--RPPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPPPLPPPPPV 1561
Query: 612 PTQDLTPTRPLPSALEEALSNHPFRTG--DTGNPVEDWEAKNHSGKPTNSPVPEQSFPPT 669
+P SA+E+ + G DT D + N K + +P P
Sbjct: 1562 -------IKPQTSAVEQERWDEDSFYGLWDT----NDEQGLNSEFKSETAAIPSAPVLPP 1610
Query: 670 PKTFCPSPQPPRGP---GVSTISKPVMVHQEPNF 700
P S PP GP G+ +SKP V Q ++
Sbjct: 1611 PPVH--SSIPPPGPVPMGMPPMSKPPPVQQTVDY 1642
Score = 43.9 bits (102), Expect = 7e-04
Identities = 52/194 (26%), Positives = 72/194 (37%), Gaps = 33/194 (17%)
Query: 516 PPPPPSVSPLAPPL-----RRFAGGLHLHTTDLDD--IPLDMFYYPPKTPSALP--VMPH 566
PPPPP P P L +++ + H D +P+++ PP++P P MP
Sbjct: 102 PPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLVPMEL-ESPPESPPVPPGSYMPP 160
Query: 567 -----PPPSNPPHKVP---APPVLPLSGHVSASSSPWVQRTPPPIPIPPPPS-------- 610
PPP PP P + P LP S S SP Q P P S
Sbjct: 161 SQSYMPPPQPPPSYYPPTSSQPYLP-PAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLS 219
Query: 611 -----VPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQS 665
+P+ +P+RP + L P + GN + SG S +Q+
Sbjct: 220 HSQSYLPSSQASPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQA 279
Query: 666 FP-PTPKTFCPSPQ 678
P P P T P Q
Sbjct: 280 APEPDPSTMTPQEQ 293
Score = 37.7 bits (86), Expect = 0.048
Identities = 35/137 (25%), Positives = 47/137 (34%), Gaps = 9/137 (6%)
Query: 554 PPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVPT 613
P + S ++ PPPS PP PL S+ Q P P P P
Sbjct: 235 PSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPSTMTPQEQQ 294
Query: 614 QDLTPTRPLPSALEEALSNH-------PFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSF 666
Q L +L++ H P DT PV++ + + SP E+
Sbjct: 295 QYWYRQHLL--SLQQRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEPP 352
Query: 667 PPTPKTFCPSPQPPRGP 683
P P P P PP P
Sbjct: 353 LPPPNEEVPPPLPPEEP 369
Score = 31.6 bits (70), Expect = 3.5
Identities = 27/97 (27%), Positives = 39/97 (40%), Gaps = 17/97 (17%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLH------------TTDLDDIPLDMFYYPPKTPSALP 562
PPPPPP + P P ++ + T D + + PSA P
Sbjct: 1548 PPPPPPPLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSETAAIPSA-P 1606
Query: 563 VMPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQRT 599
V+P PP + +P P +P+ G S P VQ+T
Sbjct: 1607 VLPPPPVHS---SIPPPGPVPM-GMPPMSKPPPVQQT 1639
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 61.2 bits (147), Expect = 4e-09
Identities = 65/197 (32%), Positives = 74/197 (37%), Gaps = 37/197 (18%)
Query: 515 PPPPPPSVSPLAP-----PLRRFAGGLHLHTTDLDDIPLDMFYYPPK-TPSALPVMPHP- 567
PPPPPP +PL P PL T P+ PP TP P P
Sbjct: 763 PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTV----APVVTQAAPPTPTPPVPPAKKQPA 818
Query: 568 ------PPSNPPHKVPAPP-VLPLSGHVSASSSPWVQRTPPPIPIPPPPSVPTQDLT--P 618
PPS P VP PP LP A PPP P+ P PSV Q + P
Sbjct: 819 FPASYIPPSPPTPPVPVPPPTLPKQQSFCAK--------PPPSPLSPVPSVVKQIASQFP 870
Query: 619 TRPLPSALE-EALSNHPFRTGDTGNPVEDWEAK-NHSGKPTNSP-----VPEQS--FPPT 669
P P A+E + L P P + K S P SP PE S FPP
Sbjct: 871 PPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP 930
Query: 670 PKTFCPSPQPPRGPGVS 686
P + P+P PP P S
Sbjct: 931 PPSPVPAPPPPPPPTAS 947
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/193 (30%), Positives = 76/193 (39%), Gaps = 30/193 (15%)
Query: 508 ISEMTTGPPPPPPSV----SPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPP-KTPSALP 562
I+++ PPPPP + P APP + T+ P+ PP TP P
Sbjct: 755 ITQVAPPTPPPPPPIPAPLPPQAPPKPLVT--IPAPTSTKTVAPVVTQAAPPTPTPPVPP 812
Query: 563 VMPHP-------PPSNPPHKVPA-PPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVPTQ 614
P PPS P VP PP LP A PPP P+ P PSV Q
Sbjct: 813 AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAK--------PPPSPLSPVPSVVKQ 864
Query: 615 DLT--PTRPLPSALE-EALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSF-PPTP 670
+ P P P A+E + L P P + K +P++ PVP F PP P
Sbjct: 865 IASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPK---WQPSSIPVPSPDFPPPPP 921
Query: 671 KTFCPSPQPPRGP 683
++ P PP P
Sbjct: 922 ESSLVFPPPPPSP 934
Score = 48.5 bits (114), Expect = 3e-05
Identities = 43/153 (28%), Positives = 59/153 (38%), Gaps = 27/153 (17%)
Query: 571 NPPHKVPAPPVLP----LSGHVSASSSPWVQRTPPPIPIPPPPSVPTQDLTPTRPLPSAL 626
N P+ PP+ P ++ + ++ SP + PPP P PPPP P P++ PSA
Sbjct: 599 NRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAG 658
Query: 627 EEA-----------LSNHPFRTGDTGNPVEDWEAKNHSGK-----PTNSPVPEQSFPPTP 670
A L N +G P ++ S K P N VP PP P
Sbjct: 659 SAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPP 718
Query: 671 KT-------FCPSPQPPRGPGVSTISKPVMVHQ 696
T P+P P P S P+ +HQ
Sbjct: 719 PTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQ 751
Score = 45.8 bits (107), Expect = 2e-04
Identities = 47/186 (25%), Positives = 67/186 (36%), Gaps = 26/186 (13%)
Query: 498 LEQISSADNEISEMTTGPPPPPP-----------SVSPLAPPLRRFAGGLHLHTTDLDDI 546
L + S +I+ PP PP +V+P +PP + I
Sbjct: 855 LSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKP-----KWQPSSI 909
Query: 547 PLDMFYYPPKTPSALPVMPHPPPSN-PPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIPI 605
P+ +PP P + V P PPPS P P PP + S S +T P
Sbjct: 910 PVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK 969
Query: 606 PPPPSVPTQDLTPTRPLPSALEEALSNHPF-RTGDTGNPVEDWEAKNHSGKPTNSPVPEQ 664
PPP TP R S + + HP + + V + SG P+ +P
Sbjct: 970 KPPP-------TPQRN-SSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPP 1021
Query: 665 SFPPTP 670
+ PP P
Sbjct: 1022 AAPPKP 1027
Score = 43.9 bits (102), Expect = 7e-04
Identities = 49/208 (23%), Positives = 68/208 (32%), Gaps = 49/208 (23%)
Query: 553 YPPKTPSA-LPVMPHPPPSNPPHKVPAPPVLPLSGHVSASSS------------------ 593
Y PS LP P PPP PP P PP LP SA S+
Sbjct: 619 YTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQ 678
Query: 594 --------------------PWVQRTP----PPIPIPPPPSVPTQDLTPTRP---LPSAL 626
P + P PP P PPPP P + +P PS
Sbjct: 679 HSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLP 738
Query: 627 EEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQPPR--GPG 684
+ + P + + + P +P+P Q+ PP P P+P + P
Sbjct: 739 QFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQA-PPKPLVTIPAPTSTKTVAPV 797
Query: 685 VSTISKPVMVHQEPNFIYRPAVKSEVLP 712
V+ + P P +PA + +P
Sbjct: 798 VTQAAPPTPTPPVPPAKKQPAFPASYIP 825
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 61.2 bits (147), Expect = 4e-09
Identities = 77/290 (26%), Positives = 111/290 (38%), Gaps = 59/290 (20%)
Query: 459 KEKQLKINRLAQEVSETEREDLEESEKIQYWV--ERLCQTRLEQISSADNEISEMTTGPP 516
K+++ K++ +E E E +D E EK + V E + E+ ++ PP
Sbjct: 355 KKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPP 414
Query: 517 PP--PPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPP----- 569
PP PPS SP PPL PP P + P +P PPP
Sbjct: 415 PPLPPPSTSP-PPPL----------------------CPPPPPPVSPPPLPSPPPPPAQE 451
Query: 570 ---SNPPHKVPA--------PPVLPLSGHVSASSSPWVQRTPPPIPIP------PP---P 609
+PP VPA PP+ P ++ + T PP P P PP P
Sbjct: 452 EQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSP 511
Query: 610 SVPTQDLTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPV---PEQSF 666
+V + T + + + +S R T D E K SPV P +
Sbjct: 512 TVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMD-EDPPKPPKVEVSPVLRPPITTS 570
Query: 667 PPTPKTFCPSPQPPRGPGVSTISKPVMVHQEPNFIYR-PAVKSEVLPQEM 715
PP P+ P P PPR P + S PV + ++ I R P + L +E+
Sbjct: 571 PPVPQEPAPVPSPPRAP--TPPSTPVPLPEKRRSILREPTFRWTSLTREL 618
Score = 45.8 bits (107), Expect = 2e-04
Identities = 54/198 (27%), Positives = 69/198 (34%), Gaps = 47/198 (23%)
Query: 513 TGPPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHP----- 567
T PP P PS + PP TT L +I F P + + V+ P
Sbjct: 492 TSPPTPTPSTATGGPP-EDSPTVAPKSTTFLKNIR--QFIMPVVSARSSRVIKTPRRFMD 548
Query: 568 -PPSNPPHKVPAPPVLPLSGHVSASSSPWVQRTPP----PIPIPPPPSVPTQDLTPTRPL 622
P PP KV PVL P + +PP P P+P PP PT TP PL
Sbjct: 549 EDPPKPP-KVEVSPVL----------RPPITTSPPVPQEPAPVPSPPRAPTPPSTPV-PL 596
Query: 623 PSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQPPRG 682
P L FR W + + PP P P P P
Sbjct: 597 PEKRRSILREPTFR----------WTSLT------------RELPPPPPAPPPPPAPSPP 634
Query: 683 PGVSTISKPVMVHQEPNF 700
P +T S+ ++ + P F
Sbjct: 635 PAPATSSRRPLLLRAPQF 652
Score = 43.1 bits (100), Expect = 0.001
Identities = 58/229 (25%), Positives = 76/229 (33%), Gaps = 70/229 (30%)
Query: 515 PPPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPV----------- 563
P PP VSP+ P + + + P PP TP LP
Sbjct: 552 PKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPT--PPSTPVPLPEKRRSILREPTF 609
Query: 564 --------MPHPPPSNPPHKVPAPPVLPLSGHVSASSSPWVQR----------------- 598
+P PPP+ PP P+PP P ++S P + R
Sbjct: 610 RWTSLTRELPPPPPAPPPPPAPSPPPAP----ATSSRRPLLLRAPQFTPSEAHLKIYESV 665
Query: 599 -TPPPIPIP--PPPSVPTQDLTPTRPLPSALEEALSNH---PFRTGDTGNPVEDWEAKNH 652
TPPP+ P P P P D +P P P A+ +NH P PV+ E H
Sbjct: 666 LTPPPLGAPEAPEPEPPPADDSPAEPEPRAV--GRTNHLSLPRFAPVVTTPVKA-EVSPH 722
Query: 653 SGKPTNSPVPE------------------QSFPPTPKTFCPSPQPPRGP 683
G P S P+ Q+ PP P P P + P
Sbjct: 723 -GAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMP 770
Score = 42.7 bits (99), Expect = 0.002
Identities = 39/131 (29%), Positives = 50/131 (38%), Gaps = 31/131 (23%)
Query: 513 TGPPPPPPSVS------PLAPPLRRFAGGL----------------HLHTTDLDDIPLDM 550
+ PPP P S S P P RR GG+ H+ T D P
Sbjct: 1851 SAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAP- 1909
Query: 551 FYYPPKTPSALPVMPHPPPS---NPPHKVPAPPVLPLSGHVSASSSPWVQRTPPPIPIPP 607
P ++ P+ P PPPS +PP K +P V + +P PP P P
Sbjct: 1910 ---PRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPS 1966
Query: 608 PPSVPTQDLTP 618
PP P +DL P
Sbjct: 1967 PP--PPEDLGP 1975
Score = 33.9 bits (76), Expect = 0.70
Identities = 43/174 (24%), Positives = 63/174 (36%), Gaps = 24/174 (13%)
Query: 516 PPPPPSVSPLAPPLRRFAGGLHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHK 575
PP PP++SP AP G L + + PP P L ++ P++PP +
Sbjct: 2218 PPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPA---PPPPPPPLTLVLSSGPASPPRQ 2274
Query: 576 -VPAPPVLPLSGHVSASSSPWVQRTPPPIPIPPPPSVPTQD-----LTPTRPLPSALEEA 629
+ V SG R+P P PPP P D T +P
Sbjct: 2275 AIRVKRVSTFSG-----------RSP---PAPPPYKAPRLDEDGEASEDTPQVPGLGSGG 2320
Query: 630 LSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQPPRGP 683
S +T ++ +G+ + P+ E+S P P PQ P GP
Sbjct: 2321 FSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERS-PLLPLPEDGPPQVPDGP 2373
>gi|239752551 PREDICTED: hypothetical protein [Homo sapiens]
Length = 238
Score = 60.8 bits (146), Expect = 5e-09
Identities = 48/200 (24%), Positives = 104/200 (52%), Gaps = 8/200 (4%)
Query: 326 ESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLL 385
E K ++E++EM R++ +K E+ E+ R++ E++ E+EEK ++Q E+ W +E++
Sbjct: 9 EREKKMREEEEMMREQE----EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 64
Query: 386 LPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQDLRKNKKELEF 445
+ E +P +K K + R K +R++ ++ K + ++ K + E
Sbjct: 65 EQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEKMQ-EQ 123
Query: 446 EQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVERLCQTRLEQISSAD 505
E+K+ +++E M E+E+ K+ +++ E E + E+ EK++ E++ Q + E++ +
Sbjct: 124 EEKMQEQEEMMWEQEE--KMQEQEEKMWEQEEKMREQEEKMREQEEKM-QGQEEKMRDVE 180
Query: 506 NEISEMTTGPPPPPPSVSPL 525
E G P P+ +
Sbjct: 181 PAGGEAGEGSPQDNPTAQEI 200
Score = 40.8 bits (94), Expect = 0.006
Identities = 24/103 (23%), Positives = 54/103 (52%), Gaps = 1/103 (0%)
Query: 294 RELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEEN 353
+E ERL E +R ++ Q++ Q E K +E+ + + ++ +E + E+
Sbjct: 80 KEKMWEQDERLREKEER-MREQKMWQQVEKMREKKKTQEEKMQEQEEKMQEQEEMMWEQE 138
Query: 354 ERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHP 396
E+ +++ E++ E+EEK ++Q E+ +E++ + +V P
Sbjct: 139 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRDVEP 181
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,382,494
Number of Sequences: 37866
Number of extensions: 2564341
Number of successful extensions: 43225
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 634
Number of HSP's successfully gapped in prelim test: 1679
Number of HSP's that attempted gapping in prelim test: 17091
Number of HSP's gapped (non-prelim): 14107
length of query: 899
length of database: 18,247,518
effective HSP length: 111
effective length of query: 788
effective length of database: 14,044,392
effective search space: 11066980896
effective search space used: 11066980896
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.