Search of human proteins with 38569480

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38569480 megakaryoblastic leukemia 2 protein [Homo sapiens]
         (1049 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38569480 megakaryoblastic leukemia 2 protein [Homo sapiens]       2067   0.0  
gi|14269566 megakaryoblastic leukemia 1 protein [Homo sapiens]        687   0.0  
gi|226423889 myocardin isoform 1 [Homo sapiens]                       507   e-143
gi|23957692 myocardin isoform 2 [Homo sapiens]                        506   e-143
gi|226423891 myocardin isoform 3 [Homo sapiens]                       340   3e-93
gi|91982772 mucin 17 [Homo sapiens]                                    65   3e-10
gi|195963410 MEF2 activating motif and SAP domain containing tra...    63   2e-09
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       57   7e-08
gi|150170670 piccolo isoform 2 [Homo sapiens]                          57   7e-08
gi|150378539 piccolo isoform 1 [Homo sapiens]                          57   7e-08
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   56   2e-07
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   56   2e-07
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   56   2e-07
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    56   2e-07
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   55   3e-07
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]       53   2e-06
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    52   2e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         52   2e-06
gi|148612879 polyhomeotic like 3 [Homo sapiens]                        52   3e-06
gi|31324577 molecule interacting with Rab13 [Homo sapiens]             52   4e-06
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                   51   5e-06
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       50   9e-06
gi|56549694 enabled homolog isoform a [Homo sapiens]                   50   1e-05
gi|39930375 enabled homolog isoform b [Homo sapiens]                   50   1e-05
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       50   1e-05
gi|33667044 ABI gene family, member 3 (NESH) binding protein [Ho...    50   1e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             50   1e-05
gi|4758010 clock [Homo sapiens]                                        49   2e-05
gi|241982780 programmed cell death 6 interacting protein isoform...    49   2e-05
gi|22027538 programmed cell death 6 interacting protein isoform ...    49   2e-05

>gi|38569480 megakaryoblastic leukemia 2 protein [Homo sapiens]
          Length = 1049

 Score = 2067 bits (5355), Expect = 0.0
 Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)

Query: 1    MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQR 60
            MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQR
Sbjct: 1    MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQR 60

Query: 61   RTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETF 120
            RTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETF
Sbjct: 61   RTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETF 120

Query: 121  AEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPH 180
            AEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPH
Sbjct: 121  AEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPH 180

Query: 181  TQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVP 240
            TQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVP
Sbjct: 181  TQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVP 240

Query: 241  EFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRV 300
            EFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRV
Sbjct: 241  EFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRV 300

Query: 301  KKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK 360
            KKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK
Sbjct: 301  KKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK 360

Query: 361  PLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVS 420
            PLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVS
Sbjct: 361  PLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVS 420

Query: 421  GTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVST 480
            GTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVST
Sbjct: 421  GTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVST 480

Query: 481  LKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLS 540
            LKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLS
Sbjct: 481  LKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLS 540

Query: 541  SSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKM 600
            SSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKM
Sbjct: 541  SSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKM 600

Query: 601  QLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHA 660
            QLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHA
Sbjct: 601  QLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHA 660

Query: 661  VGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPT 720
            VGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPT
Sbjct: 661  VGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPT 720

Query: 721  AALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINK 780
            AALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINK
Sbjct: 721  AALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINK 780

Query: 781  ASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIK 840
            ASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIK
Sbjct: 781  ASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIK 840

Query: 841  QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVN 900
            QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVN
Sbjct: 841  QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVN 900

Query: 901  TVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFS 960
            TVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFS
Sbjct: 901  TVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFS 960

Query: 961  LIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSS 1020
            LIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSS
Sbjct: 961  LIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSS 1020

Query: 1021 SGLTPLSTTAPSMFSADFLDPQDLPLPWD 1049
            SGLTPLSTTAPSMFSADFLDPQDLPLPWD
Sbjct: 1021 SGLTPLSTTAPSMFSADFLDPQDLPLPWD 1049


>gi|14269566 megakaryoblastic leukemia 1 protein [Homo sapiens]
          Length = 931

 Score =  687 bits (1772), Expect = 0.0
 Identities = 453/1016 (44%), Positives = 590/1016 (58%), Gaps = 126/1016 (12%)

Query: 72   MPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMK 131
            MPPLKSPAAFHEQ +SLERARTE++LK KIRSRP+RSELVRMHILEET AEPSLQA Q+K
Sbjct: 1    MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLK 60

Query: 132  LKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDS 191
            LKRARLADDLNEKIAQRPGPMELVEKNILPV+SS+KEAII VG+ +YP      SFDEDS
Sbjct: 61   LKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAII-VGQVNYPKVADSSSFDEDS 119

Query: 192  SDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQ 251
            SDALSP+QPAS ESQGS  SP E +VSE     T+ +P Q  S  P   +  +    A+Q
Sbjct: 120  SDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQ 179

Query: 252  P--PPRPAAPVLPTN--TVSSAKPGPALVKQSHPKNPNDK-HRSKKCKDPKPRVKKLKYH 306
            P  PP P  P   TN  T+ +AK  P L+KQS PK+ ++K  RSKK K+ KP+VKKLKYH
Sbjct: 180  PPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYH 239

Query: 307  QYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILS-QQKQHYNYQTILPAPFKPLNDK 365
            QYIPPDQK ++  P MDS+YA++LQQQQLFLQLQIL+ QQ+QH+NYQ ILPAP K   + 
Sbjct: 240  QYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEA 299

Query: 366  NSNSG----------NSALNNATP---NTPRQNTSTPVRKPGPLPSSLDDLKVSELKTEL 412
              +SG          NS+ ++  P      RQN+++   KPG LP++LDD+KV+ELK EL
Sbjct: 300  LGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQEL 359

Query: 413  KLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHN 472
            KLR LPVSGTK +LIERL+ YQ+  S     G   A ++++I+    EV VA P   L  
Sbjct: 360  KLRSLPVSGTKTELIERLRAYQDQISP--VPGAPKAPAATSILHKAGEVVVAFPAARLST 417

Query: 473  ---TVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNM--ADTFT 527
                V + ++  +  +    +S   +  +  S  P+SP+PSE+S LST D N    DTF 
Sbjct: 418  GPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFG 477

Query: 528  EIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLS---NLELDAAEKDRKLQEKEKQIEEL 584
            E++T       L +SPL++   E+     S  LS     EL+  +KD+ LQEK+KQIE L
Sbjct: 478  EMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEAL 537

Query: 585  KRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASL 644
             R L Q+Q+LVE LK+QLE EKR QQ  P  A                 LG+ +K E S 
Sbjct: 538  TRMLRQKQQLVERLKLQLEQEKRAQQPAPAPA----------------PLGTPVKQENSF 581

Query: 645  PDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQA 704
              C  S+QP+  A      P +      +A  A        V       VV Q    P+ 
Sbjct: 582  SSCQLSQQPLGPA-----HPFNPS----LAAPATNHIDPCAVAPGPPSVVVKQEALQPEP 632

Query: 705  GMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLP 764
                 PQ+    Q P  +L  G+AP                      + T+S  ++ VL 
Sbjct: 633  EPVPAPQLLLGPQGP--SLIKGVAPPT--------------------LITDSTGTHLVL- 669

Query: 765  YQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSS------PPPPQQFVVQ 818
                                 + ++NA  P L +G  +P +PSS      P P  Q  ++
Sbjct: 670  --------------------TVTNKNADSPGLSSG--SPQQPSSQPGSPAPAPSAQMDLE 707

Query: 819  H---SLFGSPVA-KTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEIS 874
            H    LFG+P +   K+PP YEEA+     +Q P  + + + SQQMDDLFDILI+SGEIS
Sbjct: 708  HPLQPLFGTPTSLLKKEPPGYEEAM-----SQQPKQQENGSSSQQMDDLFDILIQSGEIS 762

Query: 875  LPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEA 934
               KE PS   K +P   ++   P   + ++P P  ++ P  +  P G  S SL  +LE 
Sbjct: 763  ADFKEPPSLPGKEKPSPKTVCGSP---LAAQPSPSAEL-PQAAPPPPG--SPSLPGRLED 816

Query: 935  FLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHSGMLDHSHSPMETSETQFA-AG 993
            FL+    S+  +P L S  +  EP SLI+DL + +LS + +LDH  SPM+TSE  F    
Sbjct: 817  FLE----SSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEP 872

Query: 994  TPCLSLDLSDSNLDNMEWLDITMPNSSSGLTPLSTTAPSMFSADFLDPQDLPLPWD 1049
            +  + LDL+D +LD+M+WL+++       L PLSTTAPS+FS DFLD  DL L WD
Sbjct: 873  SSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWD 928


>gi|226423889 myocardin isoform 1 [Homo sapiens]
          Length = 986

 Score =  507 bits (1306), Expect = e-143
 Identities = 384/1060 (36%), Positives = 552/1060 (52%), Gaps = 138/1060 (13%)

Query: 37   LQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENF 96
            L S  +L   ++ ++VLQLRLQQRRT+EQL +QGI+PPLK PA FHEQ K L+  + +N 
Sbjct: 4    LGSEHSLLIRSKFRSVLQLRLQQRRTQEQLANQGIIPPLKRPAEFHEQRKHLDSDKAKNS 63

Query: 97   LKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVE 156
            LK K R+R + ++LV MHIL+ + AE S+   QMKLKRARLADDLNEKIA RPGP+ELVE
Sbjct: 64   LKRKARNRCNSADLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVE 123

Query: 157  KNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDED-SSDALSPDQPASQESQGSAASPSEP 215
            KNILPVDS+VKEAI G  +  +  +   F+F+ED SSD LSPDQ  S++ Q SA SP + 
Sbjct: 124  KNILPVDSAVKEAIKG-NQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPDA 182

Query: 216  KVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPR-----PAAPVLPTNTVSSAK 270
            K S++PS  +  T    AS S        + P+      +     P+ P+     V S  
Sbjct: 183  KASDTPSTGSLGTNQDLASGSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKS 242

Query: 271  PGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLL 330
             G            + K+R KK KDPKP+VKKLKYHQYIPPDQK EK+ P MDS YARLL
Sbjct: 243  LG------------DSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLL 290

Query: 331  QQQQLFLQLQILSQQKQ----HYNYQTILPAPFKPLND---KNSNSGNSALNNATPNTPR 383
            QQQQLFLQLQILSQQ+Q     ++Y  +  A  K  N+   +N NS ++ L+N TP +P 
Sbjct: 291  QQQQLFLQLQILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNSSSTPLSN-TPLSPV 349

Query: 384  QN-----TSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNS 438
            +N     T     KPGPLP +LDDLKVSEL+ +L++RGLPVSGTK  L++RL+P+Q+ + 
Sbjct: 350  KNSFSGQTGVSSFKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSG 409

Query: 439  SGLAAGGIVAVSSSAIVTSNPEVTVALPVT--TLHN-TVTSSVSTLKAELPPTGTSNATR 495
            + +   G +              TV  PVT  TL N   +SS S L       G++++  
Sbjct: 410  NPVPNFGDI-------------TTVTFPVTPNTLPNYQSSSSTSALSNGFYHFGSTSS-- 454

Query: 496  VENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSP 555
                 SP PISP+ S+ S       ++ DTF +     SPS  L  SP+ +   E  +S 
Sbjct: 455  -----SP-PISPASSDLSVAG----SLPDTFND----ASPSFGLHPSPVHVCTEESLMSS 500

Query: 556  TSSTLSNLELDA--AEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRG--QQQ 611
             +      ELD   +EKD+ L EK+K I EL  KL+QEQ+ VE L+MQL+ +KR    ++
Sbjct: 501  LNGGSVPSELDGLDSEKDKMLVEKQKVINELTWKLQQEQRQVEELRMQLQKQKRNNCSEK 560

Query: 612  RPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPV----ASHAVGQPVST 667
            +PL                   L +SIK E ++  C  + Q +PV    +S     P   
Sbjct: 561  KPLP-----------------FLAASIKQEEAVSSCPFASQ-VPVKRQSSSSECHPPACE 602

Query: 668  GGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAA----QIPTAAL 723
              Q      A  ++       ++Q +V+S  + SPQ   Q  P  A  +     +P +  
Sbjct: 603  AAQLQPLGNAHCVE------SSDQTNVLSSTFLSPQCSPQHSPLGAVKSPQHISLPPSPN 656

Query: 724  ASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHP-APAVQQPFINKAS 782
                 P+    Q     H +S P   +     ++ ++   P    P + ++  PF    +
Sbjct: 657  NPHFLPSSSGAQG--EGHRVSSPISSQVCTAQNSGAHDGHPPSFSPHSSSLHPPFSGAQA 714

Query: 783  NSVLQSRNAPLP----------SLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDP 832
            +S   +   P P           L +      K S P P        S   S +++   P
Sbjct: 715  DSSHGAGGNPCPKSPCVQQKMAGLHSSDKVGPKFSIPSP------TFSKSSSAISEVTQP 768

Query: 833  PRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTA 892
            P YE+A+KQ  +            SQQMD+L D+LI+SGE+    +E+ S + K+  +  
Sbjct: 769  PSYEDAVKQQMT-----------RSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIPR 817

Query: 893  SITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLP--SANEIPPLQ 950
            S  +     V+++P    + A   S  P    +   +  LE  L+   P    +++  L+
Sbjct: 818  S--SRSPTAVLTKPSASFEQASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLK 875

Query: 951  SSSEDREPFSLIEDLQ----NDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNL 1006
              SE+     +++        DL +   +L    SPM+T  +  +  +  L L  ++S  
Sbjct: 876  IGSEEPHFDGIMDGFSGKAAEDLFNAHEILPGPLSPMQTQFSPSSVDSNGLQLSFTESPW 935

Query: 1007 DNMEWLDITMPNSSSGLTPLSTTAPSMFSADFLDPQDLPL 1046
            + MEWLD+T PNS+ G + L+T++PS+F+ DFLD  DL L
Sbjct: 936  ETMEWLDLTPPNSTPGFSALTTSSPSIFNIDFLDVTDLNL 975


>gi|23957692 myocardin isoform 2 [Homo sapiens]
          Length = 938

 Score =  506 bits (1302), Expect = e-143
 Identities = 382/1045 (36%), Positives = 540/1045 (51%), Gaps = 156/1045 (14%)

Query: 37   LQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENF 96
            L S  +L   ++ ++VLQLRLQQRRT+EQL +QGI+PPLK PA FHEQ K L+  + +N 
Sbjct: 4    LGSEHSLLIRSKFRSVLQLRLQQRRTQEQLANQGIIPPLKRPAEFHEQRKHLDSDKAKNS 63

Query: 97   LKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVE 156
            LK K R+R + ++LV MHIL+ + AE S+   QMKLKRARLADDLNEKIA RPGP+ELVE
Sbjct: 64   LKRKARNRCNSADLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVE 123

Query: 157  KNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDED-SSDALSPDQPASQESQGSAASPSEP 215
            KNILPVDS+VKEAI G  +  +  +   F+F+ED SSD LSPDQ  S++ Q SA SP + 
Sbjct: 124  KNILPVDSAVKEAIKG-NQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPDA 182

Query: 216  KVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPR-----PAAPVLPTNTVSSAK 270
            K S++PS  +  T    AS S        + P+      +     P+ P+     V S  
Sbjct: 183  KASDTPSTGSLGTNQDLASGSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKS 242

Query: 271  PGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLL 330
             G            + K+R KK KDPKP+VKKLKYHQYIPPDQK EK+ P MDS YARLL
Sbjct: 243  LG------------DSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLL 290

Query: 331  QQQQLFLQLQILSQQKQ----HYNYQTILPAPFKPLND---KNSNSGNSALNNATPNTPR 383
            QQQQLFLQLQILSQQ+Q     ++Y  +  A  K  N+   +N NS ++ L+N TP +P 
Sbjct: 291  QQQQLFLQLQILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNSSSTPLSN-TPLSPV 349

Query: 384  QN-----TSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNS 438
            +N     T     KPGPLP +LDDLKVSEL+ +L++RGLPVSGTK  L++RL+P+Q+ + 
Sbjct: 350  KNSFSGQTGVSSFKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSG 409

Query: 439  SGLAAGGIVAVSSSAIVTSNPEVTVALPVT--TLHN-TVTSSVSTLKAELPPTGTSNATR 495
            + +   G +              TV  PVT  TL N   +SS S L       G++++  
Sbjct: 410  NPVPNFGDI-------------TTVTFPVTPNTLPNYQSSSSTSALSNGFYHFGSTSS-- 454

Query: 496  VENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSP 555
                 SP PISP+ S+ S       ++ DTF +     SPS  L  SP+ +   E  +S 
Sbjct: 455  -----SP-PISPASSDLSVAG----SLPDTFND----ASPSFGLHPSPVHVCTEESLMSS 500

Query: 556  TSSTLSNLELDA--AEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRG--QQQ 611
             +      ELD   +EKD+ L EK+K I EL  KL+QEQ+ VE L+MQL+ +KR    ++
Sbjct: 501  LNGGSVPSELDGLDSEKDKMLVEKQKVINELTWKLQQEQRQVEELRMQLQKQKRNNCSEK 560

Query: 612  RPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPV----ASHAVGQPVST 667
            +PL                   L +SIK E ++  C  + Q +PV    +S     P   
Sbjct: 561  KPLP-----------------FLAASIKQEEAVSSCPFASQ-VPVKRQSSSSECHPPACE 602

Query: 668  GGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGL 727
              Q      A  ++       ++Q +V+S  + SPQ   Q  P  A  +           
Sbjct: 603  AAQLQPLGNAHCVE------SSDQTNVLSSTFLSPQCSPQHSPLGAVKS----------- 645

Query: 728  APTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQ 787
                       PQH+   P      F  S+S        +     V  P  +       Q
Sbjct: 646  -----------PQHISLPPSPNNPHFLPSSSG------AQGEGHRVSSPISS-------Q 681

Query: 788  SRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQA 847
               A +  L +      K S P P        S   S +++   PP YE+A+KQ  +   
Sbjct: 682  VCTAQMAGLHSSDKVGPKFSIPSP------TFSKSSSAISEVTQPPSYEDAVKQQMT--- 732

Query: 848  PLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPP 907
                     SQQMD+L D+LI+SGE+    +E+ S + K+  +  S  +     V+++P 
Sbjct: 733  --------RSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIPRS--SRSPTAVLTKPS 782

Query: 908  PQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLP--SANEIPPLQSSSEDREPFSLIEDL 965
               + A   S  P    +   +  LE  L+   P    +++  L+  SE+     +++  
Sbjct: 783  ASFEQASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLKIGSEEPHFDGIMDGF 842

Query: 966  Q----NDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSS 1021
                  DL +   +L    SPM+T  +  +  +  L L  ++S  + MEWLD+T PNS+ 
Sbjct: 843  SGKAAEDLFNAHEILPGPLSPMQTQFSPSSVDSNGLQLSFTESPWETMEWLDLTPPNSTP 902

Query: 1022 GLTPLSTTAPSMFSADFLDPQDLPL 1046
            G + L+T++PS+F+ DFLD  DL L
Sbjct: 903  GFSALTTSSPSIFNIDFLDVTDLNL 927


>gi|226423891 myocardin isoform 3 [Homo sapiens]
          Length = 684

 Score =  340 bits (873), Expect = 3e-93
 Identities = 276/756 (36%), Positives = 383/756 (50%), Gaps = 119/756 (15%)

Query: 130 MKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDE 189
           MKLKRARLADDLNEKIA RPGP+ELVEKNILPVDS+VKEAI G  +  +  +   F+F+E
Sbjct: 1   MKLKRARLADDLNEKIALRPGPLELVEKNILPVDSAVKEAIKG-NQVSFSKSTDAFAFEE 59

Query: 190 DSS-DALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPT 248
           DSS D LSPDQ  S++ Q SA SP + K S++PS  +  T    AS S        + P+
Sbjct: 60  DSSSDGLSPDQTRSEDPQNSAGSPPDAKASDTPSTGSLGTNQDLASGSENDRNDSASQPS 119

Query: 249 ADQPPPR-----PAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKL 303
                 +     P+ P+     V S   G            + K+R KK KDPKP+VKKL
Sbjct: 120 HQSDAGKQGLGPPSTPIAVHAAVKSKSLG------------DSKNRHKKPKDPKPKVKKL 167

Query: 304 KYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQ----HYNYQTILPAPF 359
           KYHQYIPPDQK EK+ P MDS YARLLQQQQLFLQLQILSQQ+Q     ++Y  +  A  
Sbjct: 168 KYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQHRFSYLGMHQAQL 227

Query: 360 KPLND---KNSNSGNSALNNATPNTPRQN-----TSTPVRKPGPLPSSLDDLKVSELKTE 411
           K  N+   +N NS ++ L+N TP +P +N     T     KPGPLP +LDDLKVSEL+ +
Sbjct: 228 KEPNEQMVRNPNSSSTPLSN-TPLSPVKNSFSGQTGVSSFKPGPLPPNLDDLKVSELRQQ 286

Query: 412 LKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVT--T 469
           L++RGLPVSGTK  L++RL+P+Q+ + + +   G +              TV  PVT  T
Sbjct: 287 LRIRGLPVSGTKTALMDRLRPFQDCSGNPVPNFGDI-------------TTVTFPVTPNT 333

Query: 470 LHN-TVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTE 528
           L N   +SS S L       G++++       SP PISP+ S+ S       ++ DTF +
Sbjct: 334 LPNYQSSSSTSALSNGFYHFGSTSS-------SP-PISPASSDLSVAG----SLPDTFND 381

Query: 529 IMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDA--AEKDRKLQEKEKQIEELKR 586
                SPS  L  SP+ +   E  +S  +      ELD   +EKD+ L EK+K I EL  
Sbjct: 382 ----ASPSFGLHPSPVHVCTEESLMSSLNGGSVPSELDGLDSEKDKMLVEKQKVINELTW 437

Query: 587 KLEQEQKLVEVLKMQLEVEKRG--QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASL 644
           KL+QEQ+ VE L+MQL+ +KR    +++PL                   L +SIK E ++
Sbjct: 438 KLQQEQRQVEELRMQLQKQKRNNCSEKKPLP-----------------FLAASIKQEEAV 480

Query: 645 PDCSSSRQPIPV----ASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYT 700
             C  + Q +PV    +S     P     Q      A  ++       ++Q +V+S  + 
Sbjct: 481 SSCPFASQ-VPVKRQSSSSECHPPACEAAQLQPLGNAHCVE------SSDQTNVLSSTFL 533

Query: 701 SPQAGMQTQPQIATAA----QIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNS 756
           SPQ   Q  P  A  +     +P +       P+    Q     H +S P   +     +
Sbjct: 534 SPQCSPQHSPLGAVKSPQHISLPPSPNNPHFLPSSSGAQG--EGHRVSSPISSQVCTAQN 591

Query: 757 ASSNTVLPYQRHP-APAVQQPFINKASNSVLQSRNAPLP----------SLQNGPNTPNK 805
           + ++   P    P + ++  PF    ++S   +   P P           L +      K
Sbjct: 592 SGAHDGHPPSFSPHSSSLHPPFSGAQADSSHGAGGNPCPKSPCVQQKMAGLHSSDKVGPK 651

Query: 806 PSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQ 841
            S P P        S   S +++   PP YE+A+KQ
Sbjct: 652 FSIPSP------TFSKSSSAISEVTQPPSYEDAVKQ 681


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 186/889 (20%), Positives = 302/889 (33%), Gaps = 123/889 (13%)

Query: 191  SSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQF-ASVSPTVPEFLKTPPT- 248
            +S A+S     ++ +  + ++PSE   + +  PV+T T A    +   T P    TP T 
Sbjct: 1841 TSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTT 1900

Query: 249  ---ADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHR--SKKCKDPKPRVKKL 303
                   P       +PT+T    +P    +  S     + +    S    D +  V   
Sbjct: 1901 YAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTY 1960

Query: 304  KYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLN 363
                  P    G        S  +  L    L   L + S+        T+   P     
Sbjct: 1961 SQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEA------STLSTTPVDTST 2014

Query: 364  DKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTK 423
               +++  S+       T  Q TSTP  +  PL      + VS     +   G  +S T 
Sbjct: 2015 PATTSTEGSSSPTTAGGTSIQ-TSTPSERTTPLAG----MPVSTTLV-VSSEGNTLSTTP 2068

Query: 424  PDLIERLKPYQEVNSSGLAAGGIVAVSS----SAIVTSNPEVT--VALP-VTTLHNT--- 473
             D   ++    E +SS  A G  + +S+    S ++TS P  T  VA P  +TL  T   
Sbjct: 2069 VDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVD 2128

Query: 474  ----VTSSVSTLKAELPPTGTSNATRV-ENVHSPL---PISPSPSEQSSLSTDDTNMADT 525
                V +S     + +P  GTS  T    +  +PL   P+S +    S++ST  T   DT
Sbjct: 2129 SNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDT 2188

Query: 526  FTEIM----TMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQI 581
             T +        SP+    +S    T +E S   TS  +S + +  +E            
Sbjct: 2189 STPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTS 2248

Query: 582  EELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDE 641
              +    E            +      +   PL + P +  H++ ++ +  +L ++  D 
Sbjct: 2249 TPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVS--HTLVANSEVSTLSTTPVDS 2306

Query: 642  ASLPDCSSSRQPIPVASHAVGQPVSTG--GQTLVAKKAV----VIKQEVPVGQAEQQSVV 695
             +    S+     P  +     P ST   G T + +  V    V   E            
Sbjct: 2307 NTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTS 2366

Query: 696  SQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTN 755
            +   T  QAG  + P  A    +PT+  + G  P            + S P     V ++
Sbjct: 2367 TPVTTYSQAG--SSPTTADDTSMPTSTYSEGSTP------------LTSVPVSTMPVVSS 2412

Query: 756  SASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQF 815
             AS+++  P               +AS+S   +    +P+      T    S P      
Sbjct: 2413 EASTHSTTPVDTSTPVTTS----TEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPV 2468

Query: 816  VVQH--SLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEI 873
            V     +L  +PV  +       EA     + +  +  IS A S+    L  I + +  +
Sbjct: 2469 VSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTA-SEGSTLLTSIPVSTTPV 2527

Query: 874  SLPIKE--EPSPISKMRPVTASI-----------TTMPVNTVVSRPPPQVQMAPPVSLEP 920
            + P       +P+    PV  S            T+MP +T      P   M  PVS +P
Sbjct: 2528 ASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSM--PVSTKP 2585

Query: 921  MGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHSGMLDHSH 980
            + S  AS  +        T P    IP   S+                        + S 
Sbjct: 2586 LASSEASTLS--------TTPVDTSIPVTTST------------------------ETSS 2613

Query: 981  SPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSSGLTPLSTT 1029
            SP    +T     TP      S+ +      L  TMP +SS  + LSTT
Sbjct: 2614 SPTTAKDTSMPISTP------SEVSTSLTSILVSTMPVASSEASTLSTT 2656



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 151/709 (21%), Positives = 251/709 (35%), Gaps = 74/709 (10%)

Query: 367  SNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVS------ 420
            S+S  SA   + P +     STP+R        L   + S L T      +PV+      
Sbjct: 2553 SSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETS 2612

Query: 421  ---GTKPDLIERLKPYQEVNSS--GLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVT 475
                T  D    +    EV++S   +    +   SS A   S   V     VTT   T +
Sbjct: 2613 SSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGT-S 2671

Query: 476  SSVSTLKAELPPTGT--SNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMM 533
            SS +T +    PT T    +T + N+     +S +    S  ST  T   DT T + T  
Sbjct: 2672 SSPTTAEGSSMPTSTPGERSTPLTNI----LVSTTLLANSEASTLSTTPVDTSTPVTT-- 2725

Query: 534  SPSQFLSSSP-------LRMTNNEDSLSP-TSSTLSNLELDAAEKDRKLQEKEKQIEELK 585
              S   SSSP       +R++   D  +P TS  +S L + ++E              + 
Sbjct: 2726 --SAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVT 2783

Query: 586  RKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLP 645
               E            +      +   PL + P    H+  +  + G+L ++  D ++  
Sbjct: 2784 TSTEASSSPTTAEVTSMPTSTPSETSTPLTSMP--VNHTPVASSEAGTLSTTPVDTSTPV 2841

Query: 646  DCSSSRQPIPVASHAVGQPVSTGGQ------------TLVAKKAVVIKQEVPVGQAEQQS 693
              S+     P  +  +  P+ST  +            T VA          PV  +   +
Sbjct: 2842 TTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVT 2901

Query: 694  VVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVF 753
              ++  +SP     T   I+T +++ T  L S L  TVP    +    + + P   R   
Sbjct: 2902 TSTEGSSSPTTAEGTSMPISTPSEVST-PLTSILVSTVP-VAGSEASTLSTTPVDTRTPV 2959

Query: 754  TNSA---SSNTVLPYQRHP--APAVQQPFINKASNSVLQSRNAPLPSLQNGP---NTPNK 805
            T SA   SS T       P   P  ++  +   S S +   ++   +L   P   +TP  
Sbjct: 2960 TTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVT 3019

Query: 806  PSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFD 865
             S+         + +  G P++   +      +I    +T   +PE S   +  +D    
Sbjct: 3020 TSTEASSSPTTAEGT--GIPISTPSEGSTPLTSI-PVSTTPVAIPEASTLSTTPVDSNSP 3076

Query: 866  ILIKSGEISLPIKEEPS--PISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGS 923
            ++  +   S P   E +  PIS     +  +T +PV+T     P        +S  P+ +
Sbjct: 3077 VVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTT----PVTSSAISTLSTTPVDT 3132

Query: 924  LSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHSGMLDHSHSPM 983
             S  +    EA    T      + P  + SE   P +         +  S ML  S    
Sbjct: 3133 -STPVTTSTEAHSSPTTSEGTSM-PTSTPSEGSTPLT--------YMPVSTMLVVSSEDS 3182

Query: 984  ETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSSGLTPLSTTAPS 1032
              S T     TP ++     ++    E   I     S G+TPL++   S
Sbjct: 3183 TLSATPVDTSTP-VTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVS 3230



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 150/689 (21%), Positives = 247/689 (35%), Gaps = 125/689 (18%)

Query: 381  TPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSG 440
            T  + TS P   P    + L  + VS +   +      +S T  D    +    E  SS 
Sbjct: 3147 TTSEGTSMPTSTPSEGSTPLTYMPVSTMLV-VSSEDSTLSATPVDTSTPVTTSTEATSST 3205

Query: 441  LAAGGIVAVSS--------SAIVTSNPEVTVA----LPVTTLHNTVTSSVSTLKAELPPT 488
             A G  +  S+        +++  SN  V  +    L  T + +    + ST  +  PPT
Sbjct: 3206 TAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPT 3265

Query: 489  --GTSNATRVENVHSP----LPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSS 542
              GTS  T   +  S     +P+S +    S  ST  T  ADT T + T    SQ  SS 
Sbjct: 3266 AEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTY---SQASSSP 3322

Query: 543  PLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQL 602
            P+      D  S  +ST S                           E    L  +     
Sbjct: 3323 PI-----ADGTSMPTSTYS---------------------------EGSTPLTNMSFSTT 3350

Query: 603  EVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVG 662
             V     +   L   P      V +  +  SL  +  +  S+P  S S    P+AS    
Sbjct: 3351 PVV--SSEASTLSTTPVDTSTPVTTSTE-ASLSPTTAEGTSIPTSSPSEGTTPLAS---- 3403

Query: 663  QPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAA 722
             PVST   T V    V      PV   +  ++V+   TS +A   + P IA    +PT+ 
Sbjct: 3404 MPVST---TPVVSSEVNTLSTTPV---DSNTLVT---TSTEA--SSSPTIAEGTSLPTST 3452

Query: 723  LASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKAS 782
             + G  P       T P            V ++ AS+ +  P           P    +S
Sbjct: 3453 TSEGSTPLSIMPLSTTP------------VASSEASTLSTTPVDTSTPVTTSSP--TNSS 3498

Query: 783  NSVLQSRNAPLPSLQNGPNTP--NKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIK 840
             +  +  + P  +   G +TP  N P S  P        +L  +PV    D   +  +  
Sbjct: 3499 PTTAEVTSMPTSTAGEG-STPLTNMPVSTTPVASSEAS-TLSTTPV----DSNTFVTSSS 3552

Query: 841  QTRSTQAPLPEIS---NAHSQQMDDLFDILIKSGEISLPIKEEPS--PISKMRPVTASI- 894
            Q  S+ A L   +   +  S+    L  +L+ S  ++      PS   + +  PVT S  
Sbjct: 3553 QASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQ 3612

Query: 895  ---TTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQS 951
               T  P   +        +++ P+++ P+ + S ++    EA    TLP     P + S
Sbjct: 3613 SNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTIS---EAGTASTLPVDTSTPVITS 3669

Query: 952  SSEDREPFSLIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEW 1011
            +     P           ++  G      +P E S       TP  ++ +S + + + E 
Sbjct: 3670 TQVSSSP-----------VTPEGTTMPIWTPSEGS-------TPLTTMPVSTTRVTSSEG 3711

Query: 1012 LDITMPNSSSGLTPLSTTAPSMFSADFLD 1040
              ++ P+  +  TP++T+  ++ S+  LD
Sbjct: 3712 STLSTPSVVTS-TPVTTSTEAISSSATLD 3739



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 126/616 (20%), Positives = 216/616 (35%), Gaps = 73/616 (11%)

Query: 450  SSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSP 509
            SS A   S   V  + PVTT     +SS +T +  + P  T  A+    + + +P+S +P
Sbjct: 2824 SSEAGTLSTTPVDTSTPVTT-STKASSSPTTAEGIVVPIST--ASEGSTLLTSIPVSTTP 2880

Query: 510  SEQSSLSTDDTNMADTFTEIMT----MMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLEL 565
               S  ST  T   DT   + T      SP+    +S    T +E S   TS  +S + +
Sbjct: 2881 VASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPV 2940

Query: 566  DAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSV 625
              +E              +    E            + +   G+++ PL +   +     
Sbjct: 2941 AGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVA 3000

Query: 626  KSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAV-VIKQEV 684
             S+    +L  +  D ++    S+     P  +   G P+ST  +      ++ V    V
Sbjct: 3001 SSEA--STLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPV 3058

Query: 685  PVGQAEQQSVVSQFYTSP---QAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQH 741
             + +A   S       SP      + + P  A    +P +  + G  P       T P  
Sbjct: 3059 AIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTP-- 3116

Query: 742  VLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPN 801
                      V +++ S+ +  P               +A +S   S    +P+     +
Sbjct: 3117 ----------VTSSAISTLSTTPVDTSTPVTTS----TEAHSSPTTSEGTSMPT-----S 3157

Query: 802  TPNKPSSP----PPPQQFVV---QHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISN 854
            TP++ S+P    P     VV     +L  +PV  +       EA   T +    +P  ++
Sbjct: 3158 TPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIP--TS 3215

Query: 855  AHSQQMDDLFDILIK-----SGEISL----PIKEE----PSPISKMRPVTASITTMPVNT 901
              S+ M  L  + +      S E S+    P+        S  +   P TA  T+MP +T
Sbjct: 3216 TPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTST 3275

Query: 902  VVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLD---GTLPSANEIPPLQSSSEDREP 958
                  P   M  PVS   + S   S  +   A       T   A+  PP+   +    P
Sbjct: 3276 PSEGSTPLTSM--PVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTS--MP 3331

Query: 959  FSLIEDLQNDLLSHSGMLDHSHSPMETSE------TQFAAGTPCLSLDLSDSNLDNMEWL 1012
             S   +    L +    +  S +P+ +SE      T     TP  +   +  +    E  
Sbjct: 3332 TSTYSEGSTPLTN----MSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGT 3387

Query: 1013 DITMPNSSSGLTPLST 1028
             I   + S G TPL++
Sbjct: 3388 SIPTSSPSEGTTPLAS 3403



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 160/787 (20%), Positives = 269/787 (34%), Gaps = 105/787 (13%)

Query: 191  SSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQF-ASVSPTVPEFLKTPPT- 248
            +S   S   P ++ +    ++PSE     +  PV+T T A    S   T P    TP T 
Sbjct: 3255 TSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTT 3314

Query: 249  ---ADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKY 305
               A   PP      +PT+T S       L   S    P     +               
Sbjct: 3315 YSQASSSPPIADGTSMPTSTYSEG--STPLTNMSFSTTPVVSSEASTLST---------- 3362

Query: 306  HQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPL--N 363
                P D     + P   S  A L         +   S   +       +P    P+  +
Sbjct: 3363 ---TPVD----TSTPVTTSTEASLSPTTAEGTSIP-TSSPSEGTTPLASMPVSTTPVVSS 3414

Query: 364  DKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTK 423
            + N+ S     +N    T  + +S+P    G   +SL     SE  T L +  +P+S T 
Sbjct: 3415 EVNTLSTTPVDSNTLVTTSTEASSSPTIAEG---TSLPTSTTSEGSTPLSI--MPLSTTP 3469

Query: 424  PDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKA 483
                                   VA S ++ +++ P V  + PVTT   T  SS +T + 
Sbjct: 3470 -----------------------VASSEASTLSTTP-VDTSTPVTTSSPT-NSSPTTAEV 3504

Query: 484  ELPPTGTSNATRVENVHSPLPISP-SPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSS 542
               PT T+        + P+  +P + SE S+LST   +     T      S    L  +
Sbjct: 3505 TSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVT 3564

Query: 543  PLRM-TNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQ 601
             +RM T +E S S T+  LS+  + ++E          +   +    +          + 
Sbjct: 3565 TMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVIT 3624

Query: 602  LEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAV 661
            L +    +   PL   P +      S+    S         +LP  +S+  P+  ++   
Sbjct: 3625 LPMSTPSEVSTPLTIMPVSTTSVTISEAGTAS---------TLPVDTST--PVITSTQVS 3673

Query: 662  GQPVSTGGQTL---VAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQI 718
              PV+  G T+      +       +PV             TS +    + P + T+  +
Sbjct: 3674 SSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTR--------VTSSEGSTLSTPSVVTSTPV 3725

Query: 719  PTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQ-PF 777
             T+  A   + T+  T  +     +S P ++  + T    S T  P  R P  +    P 
Sbjct: 3726 TTSTEAISSSATLDSTTMS-----VSMPMEISTLGTTILVSTT--PVTRFPESSTPSIPS 3778

Query: 778  INKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEE 837
            +  + +    S  +  P+   G  T   P S    +  ++   L  SP++    P     
Sbjct: 3779 VYTSMSMTTASEGSSSPTTLEG--TTTMPMSTTSERSTLLTTVLI-SPIS-VMSPSEAST 3834

Query: 838  AIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPS-PISKMRPVTASITT 896
                   T  PL   + A S      F I  +   I + I  E S P++ +   T   T+
Sbjct: 3835 LSTPPGDTSTPLLTSTKAGS------FSIPAEVTTIRISITSERSTPLTTLLVSTTLPTS 3888

Query: 897  MPVNTVVSRPP--PQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSAN-EIP--PLQS 951
             P  ++ S PP        P        ++  +    +    +G+ P     IP  P+ S
Sbjct: 3889 FPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTS 3948

Query: 952  SSEDREP 958
            S+ D  P
Sbjct: 3949 STADVFP 3955



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 150/707 (21%), Positives = 238/707 (33%), Gaps = 114/707 (16%)

Query: 364  DKNSNSGNSALNNATPNTPRQNTSTPVRKPGP-------LPSSLDDLKVSELKTELKLRG 416
            D ++   NS    ++P T  + TS P   PG        +P S   +  SE +T      
Sbjct: 891  DTSTPVTNSTEARSSPTTS-EGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEART------ 943

Query: 417  LPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTS 476
              +S T  D    +    E  SS   A G    +S+    + P  +  +  T + N+  S
Sbjct: 944  --LSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEAS 1001

Query: 477  SVSTLKAEL-------------PPT--GTSNATRVENVHSP----LPISPSPSEQSSLST 517
            ++ST   +              PPT  GTS  T   +  S     +P+S +    S  ST
Sbjct: 1002 TLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETST 1061

Query: 518  DDTNMADTFTEIMTMMSPSQFLS----SSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRK 573
              T  ADT T + T    S   +    +S    T +E S   TS  +S   + ++E    
Sbjct: 1062 LSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTL 1121

Query: 574  LQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGS 633
                      +    E            +      +   PL + P +    V S+    +
Sbjct: 1122 STTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEA--NT 1179

Query: 634  LGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQS 693
            L ++  D  +    S+     P  +     P ST G+      ++ ++   PV  +E   
Sbjct: 1180 LSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVR-HTPVASSE--- 1235

Query: 694  VVSQFYTSPQAGMQTQPQIATAAQI---PTAALASGLAPTVPQTQDTFPQHVLSQPQQVR 750
              S   TSP   + T   + T+A+    PT A  + L  +      T    + S P    
Sbjct: 1236 -ASTLSTSP---VDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTL---LTSIPVSTT 1288

Query: 751  KVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPP 810
             V +  AS+    P      P V        SN V  S   P P+      T        
Sbjct: 1289 LVTSPEASTLLTTPVDT-KGPVV-------TSNEVSSS---PTPAEGTSMPTSTYSEGRT 1337

Query: 811  PPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKS 870
            P     V  +L  S           + +   T ST+A                       
Sbjct: 1338 PLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEA----------------------- 1374

Query: 871  GEISLPIKEEPSPISKMRPV--TASITTMPVNTV-VSRPPPQVQMAPPVSLEPMGSLSAS 927
               S P   E + +    P   T  +T++PV+T  V         A PV     G+ SA 
Sbjct: 1375 --CSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSA- 1431

Query: 928  LENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHSGMLDHSHSPMETSE 987
                 EA    T      I P  + SE + P   I  + N  +++S     S +P++++ 
Sbjct: 1432 -----EATSSPTTAEGISI-PTSTPSEGKTPLKSI-PVSNTPVANSEASTLSTTPVDSN- 1483

Query: 988  TQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSSGLT-----PLSTT 1029
                  +P ++     S+    E   I +   S G T     P+STT
Sbjct: 1484 ------SPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTT 1524



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 152/768 (19%), Positives = 261/768 (33%), Gaps = 140/768 (18%)

Query: 367  SNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDL 426
            ++S  +A   + P +     STP+     +P +   +  SE  T        +S T  D 
Sbjct: 667  TSSSTTAEGTSMPTSTYTEGSTPLTS---MPVNTTLVASSEAST--------LSTTPVDT 715

Query: 427  IERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTL----- 481
               +    E +SS   A G    +S+    S P  ++ +  T L ++  S++ST      
Sbjct: 716  STPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTS 775

Query: 482  -------KAELPPT---GTSNATRVENVHSPL----PISPSPSEQSSLSTDDTNMADTFT 527
                   +A   PT   GTS      +  SPL    P+S +P      ST  T   D+ +
Sbjct: 776  THITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNS 835

Query: 528  EIMTMMSPSQFLSSSP-------LRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQ 580
             + T    S  +SSSP       +  +   +  +P +S   +  L A      L      
Sbjct: 836  PVTT----STEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVD 891

Query: 581  IE-ELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIK 639
                +    E            +     G+   PL + P +    V S+ +  +L ++  
Sbjct: 892  TSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEAR--TLSATPV 949

Query: 640  DEASLPDCSSSRQPIPVASHAVGQPVSTGGQ------------TLVAKKAVVIKQEVPVG 687
            D ++    S+     P  +     P ST  +            TLVA          PV 
Sbjct: 950  DTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVD 1009

Query: 688  QAEQQSVVSQFYTSPQAGMQTQPQIATAAQ---------IPTAALASGLAPTVPQTQDTF 738
                 +  ++  + P     T    +T ++         + T  +AS    T+  T    
Sbjct: 1010 SNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADT 1069

Query: 739  PQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQP----FINKASNSVLQS----RN 790
               V +  Q      T   +S     Y     P    P     +  +  S L +     +
Sbjct: 1070 STPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTS 1129

Query: 791  APLPSLQNGPNTPNK------PSSPP-----PPQQFVVQHSLFGSPVAKTKDPPRYEEAI 839
             P+ +     ++P        P+SPP     P     V  +L  S  A T      +   
Sbjct: 1130 IPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKT 1189

Query: 840  KQTRSTQA----PLPEISNAHSQQMDDLFDILIKSGEISLPIKEEP-----------SPI 884
            +   ST+A    P  E+++  +    +    L      S+P++  P           SP+
Sbjct: 1190 QVATSTEASSPPPTAEVTSMPTSTPGERSTPL-----TSMPVRHTPVASSEASTLSTSPV 1244

Query: 885  SKMRPVTASI-----------TTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLE 933
                PVT S            T++P +T  +     +  + PVS   + S  AS      
Sbjct: 1245 DTSTPVTTSAETSSSPTTAEGTSLPTST--TSEGSTLLTSIPVSTTLVTSPEASTLLTTP 1302

Query: 934  AFLDGTLPSANEIP-----------PLQSSSEDREPFSLIEDLQNDLLSHSGMLDHSHSP 982
                G + ++NE+            P  + SE R P + I  +   L++ S +   S +P
Sbjct: 1303 VDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSI-PVNTTLVASSAISILSTTP 1361

Query: 983  METSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNS--SSGLTPLST 1028
            ++ S     +   C S   S+           +MPNS  S G TPL++
Sbjct: 1362 VDNSTPVTTSTEACSSPTTSEGT---------SMPNSNPSEGTTPLTS 1400



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 126/611 (20%), Positives = 206/611 (33%), Gaps = 69/611 (11%)

Query: 435  EVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNAT 494
            E  SS   + G    +S+    S P    ++PV+T+   VTS  STL A    T T   T
Sbjct: 2197 EARSSPTTSEGTSMPTSTPSEGSTP--FTSMPVSTMP-VVTSEASTLSATPVDTSTPVTT 2253

Query: 495  RVENVHSPLPISPSPSEQSSLSTDDTNMAD-TFTEIMTMMSPSQFLSSSPLRMTNNEDSL 553
              E   SP     +    S+LS   T +     +  +   S    LS++P+      DS 
Sbjct: 2254 STEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPV------DSN 2307

Query: 554  SP-TSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQR 612
            +P T+ST ++     AE          +      ++     +V              +  
Sbjct: 2308 TPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASF-----------ETS 2356

Query: 613  PLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTL 672
             L   P+     V +  + GS   +  D+ S+P  + S    P+ S     PVST     
Sbjct: 2357 TLSTTPADTSTPVTTYSQAGS-SPTTADDTSMPTSTYSEGSTPLTS----VPVST----- 2406

Query: 673  VAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVP 732
                  V+  E            +   TS +A   + P  A    IPT+  + G  P   
Sbjct: 2407 ----MPVVSSEASTHSTTPVDTSTPVTTSTEA--SSSPTTAEGTSIPTSPPSEGTTPLAS 2460

Query: 733  QTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQ----PFINKASNSVLQS 788
                T P  V+S             S+      +   +P   +    P    +  S L +
Sbjct: 2461 MPVSTTP--VVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLT 2518

Query: 789  RNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTK----DPPRYEEAIKQTRS 844
                  +    P      ++P      VV  +   S     +        Y E     RS
Sbjct: 2519 SIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRS 2578

Query: 845  ---TQAPL--PEISNAHSQQMDDLFDILIKSGEISLP--IKEEPSPISKMRPVTASITTM 897
               +  PL   E S   +  +D    +   +   S P   K+   PIS    V+ S+T++
Sbjct: 2579 MPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSI 2638

Query: 898  PVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDRE 957
             V+T+            PV+     +LS +  +        T  S++      SS     
Sbjct: 2639 LVSTM------------PVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTST 2686

Query: 958  PFSLIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMP 1017
            P      L N L+S + + +   S + T  T     TP  +   + S+    E   + + 
Sbjct: 2687 PGERSTPLTNILVSTTLLANSEASTLST--TPVDTSTPVTTSAEASSSPTTAEGTSMRIS 2744

Query: 1018 NSSSGLTPLST 1028
              S G TPL++
Sbjct: 2745 TPSDGSTPLTS 2755



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 123/617 (19%), Positives = 204/617 (33%), Gaps = 67/617 (10%)

Query: 450  SSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVEN---VHSPLPIS 506
            SS A   S   V  + PVTT   T +S  +     LP + TS  + +     V + L  S
Sbjct: 1233 SSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTS 1292

Query: 507  PSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELD 566
            P  S   +   D      T  E+ +  +P++  S   +  +   +  +P +S   N  L 
Sbjct: 1293 PEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTS---MPTSTYSEGRTPLTSIPVNTTLV 1349

Query: 567  AAEKDRKLQEKE-KQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSV 625
            A+     L          +    E            +      +   PL + P +    V
Sbjct: 1350 ASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVV 1409

Query: 626  KSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVP 685
             S+    +L ++  D ++    S+     P  +  +  P ST  +     K++ +    P
Sbjct: 1410 SSEAS--TLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSN-TP 1466

Query: 686  VGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQ 745
            V  +E     S   T+P             +  PT A  + +A + P    T    +   
Sbjct: 1467 VANSE----ASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVS 1522

Query: 746  PQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNK 805
               V     NS S+           PAV    +   S    Q+ ++P  +      T   
Sbjct: 1523 TTTVASSEINSLSTT----------PAVTSTPVTTYS----QASSSPTTADGTSMQTSTY 1568

Query: 806  PSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDD--- 862
                 P     V   L  S  A T      +   + T ST+A     +   S  +     
Sbjct: 1569 SEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSE 1628

Query: 863  ----LFDILIKSGEISLPIKEEPS--PISKMRPVTASI-----------TTMPVNTVVSR 905
                L  I + +  ++ P     S  P+    PV  S            T+MP +T    
Sbjct: 1629 GSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEG 1688

Query: 906  PPPQVQMA---PPVSLEPMGSLSAS-------LENQLEAFLDGTLPSANEIPPLQSSSED 955
              P   +     PV+   + +LS +       +    EA    T      +P   + SE 
Sbjct: 1689 RTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPN-STPSEG 1747

Query: 956  REPFSLIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDIT 1015
              P + I      +LS S     S +P++TS       TP  +   + S+    E   I 
Sbjct: 1748 TTPLTSIPVSTTPVLS-SEASTLSATPIDTS-------TPVTTSTEATSSPTTAEGTSIP 1799

Query: 1016 MPNSSSGLTPLSTTAPS 1032
                S G+TPL++T  S
Sbjct: 1800 TSTLSEGMTPLTSTPVS 1816



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 118/606 (19%), Positives = 207/606 (34%), Gaps = 62/606 (10%)

Query: 446  IVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPI 505
            ++ VSS A   S       +PV T   +  +S S   AE     TS  T      +  P 
Sbjct: 285  MLVVSSEASTLSTTPAATNIPVIT---STEASSSPTTAEGTSIPTSTYTEGSTPLTSTPA 341

Query: 506  SPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQF----LSSSPLRMTNNEDSLSPTSSTLS 561
            S  P   S +ST      DT T + T   PS       ++S L  T +E S   T+  +S
Sbjct: 342  STMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVS 401

Query: 562  NLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAP 621
             + + ++E              +    E            +      +   PL + P + 
Sbjct: 402  TILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVST 461

Query: 622  GHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVST--GGQTLVAKKAVV 679
                 S+    +L ++  D  +    S+     P  +     P ST   G T +   +V 
Sbjct: 462  TPVASSEA--SNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSV- 518

Query: 680  IKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALA--SGLAPTVPQTQDT 737
                +PV  +E     S   T+P   + T   + T+++  +++        PT   ++ +
Sbjct: 519  --STMPVASSE----ASTLSTTP---VDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGS 569

Query: 738  FPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQ 797
             P  + + P   R V ++ AS+ +         PA    F+  +S +   S  A   S+ 
Sbjct: 570  TP--LTNMPVSTRLVVSSEASTTST-------TPADSNTFVTTSSEASSSSTTAEGTSMP 620

Query: 798  NGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHS 857
                T              V  +L  S  A T      +     T ST+A     +   +
Sbjct: 621  ----TSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGT 676

Query: 858  QQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVS 917
                  +              E  +P++ M   T  + +   +T+ + P   V  + PV+
Sbjct: 677  SMPTSTY-------------TEGSTPLTSMPVNTTLVASSEASTLSTTP---VDTSTPVT 720

Query: 918  LEPMGSLSASLENQLEAFLDGTLPSANEIP----PLQSSSEDREPFSLIEDLQNDLLSH- 972
                 S S +  +   A +  + PS    P    P+  +       S +     D  +H 
Sbjct: 721  TSTEASSSPTTAD--GASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHI 778

Query: 973  SGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSS-GLTPLSTTAP 1031
            +   + S SP  T  T     TP     L  S    +    +T P +S+   TP+ + +P
Sbjct: 779  TTSTEASCSPTTTEGTSMPISTPSEGSPLLTS--IPVSITPVTSPEASTLSTTPVDSNSP 836

Query: 1032 SMFSAD 1037
               S +
Sbjct: 837  VTTSTE 842



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 114/617 (18%), Positives = 215/617 (34%), Gaps = 60/617 (9%)

Query: 452  SAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPT--GTSNATRVENVHSPLPISPSP 509
            S++ +  P V+      T   T + S S      P +   TS+ T  E    P+      
Sbjct: 96   SSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEE 155

Query: 510  SEQSSLSTDDTNMADTF---------TEIMTMMSPSQFLSSSPL--------RMTNNEDS 552
            S  S+++   T    +F          ++ T ++ S   SSSP         + TN+E S
Sbjct: 156  SISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGS 215

Query: 553  LSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQR 612
               TS   S +++ ++E    L    +    +    +            L          
Sbjct: 216  TPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGST 275

Query: 613  PLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTL 672
            PL   P +    V S+    S   +  +   +    +S  P      ++     T G T 
Sbjct: 276  PLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTP 335

Query: 673  VAKKAVVIKQEVPVGQAEQQSV-VSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTV 731
            +          +PV  +E  ++ ++   TS      T+P     + +PT A A+ +  + 
Sbjct: 336  LTSTPA---STMPVATSEMSTLSITPVDTSTLVTTSTEP-----SSLPTTAEATSMLTST 387

Query: 732  PQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNA 791
                 T    + + P     V ++ AS+ + +P          + F+  AS +      A
Sbjct: 388  LSEGST---PLTNMPVSTILVASSEASTTSTIPVD-------SKTFVTTASEASSSPTTA 437

Query: 792  PLPSLQNGPNTPNKPSSP--PPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPL 849
               S+    +TP++ S+P    P       S   S ++ T    + +       S+  P 
Sbjct: 438  EDTSI--ATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPT 495

Query: 850  PEISNAHSQQMDDLFDILIKSGEISLPIKE------EPSPISKMRPVT-----ASITTMP 898
             E+++  +    +    L      ++P+          +P+    PVT     +S +T P
Sbjct: 496  AEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTP 555

Query: 899  VNTVVSRPPPQVQMAP----PVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSE 954
              T +    P     P    PVS   + S  AS  +   A  +  + +++E     +++E
Sbjct: 556  EGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAE 615

Query: 955  DRE-PFSLIEDLQNDL--LSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEW 1011
                P S   +    +  +S S  L  S      S T   + TP  +   + S+    E 
Sbjct: 616  GTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEG 675

Query: 1012 LDITMPNSSSGLTPLST 1028
              +     + G TPL++
Sbjct: 676  TSMPTSTYTEGSTPLTS 692



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 127/655 (19%), Positives = 223/655 (34%), Gaps = 126/655 (19%)

Query: 386  TSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGG 445
            TS PV       S   +L  + + ++ ++     + + P   E         S G     
Sbjct: 455  TSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLT 514

Query: 446  IVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSP--- 502
             ++VS+  + +S        PV T     TSS ++  +   P GTS  T   +  S    
Sbjct: 515  SMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEAS-SSSTTPEGTSIPTSTPSEGSTPLT 573

Query: 503  -LPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLS 561
             +P+S      S  ST  T  AD+ T + T    S+  SSS    T  E +  PTS+   
Sbjct: 574  NMPVSTRLVVSSEASTTSTTPADSNTFVTT---SSEASSSS----TTAEGTSMPTST--- 623

Query: 562  NLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAP 621
                                          ++   +  M +        +    +     
Sbjct: 624  ----------------------------YSERGTTITSMSVSTTLVASSEASTLSTTPVD 655

Query: 622  GHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIK 681
             ++  +     +  S+  +  S+P  + +    P+ S     PV+T   TLVA       
Sbjct: 656  SNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTS----MPVNT---TLVASSEASTL 708

Query: 682  QEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQH 741
               PV  +      +   TS +A   + P  A  A +PT+  + G  P            
Sbjct: 709  STTPVDTS------TPVTTSTEA--SSSPTTADGASMPTSTPSEGSTP------------ 748

Query: 742  VLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPN 801
            + S P     + ++ AS+ +  P             ++ +++    +  +  P+   G +
Sbjct: 749  LTSMPVSKTLLTSSEASTLSTTP-------------LDTSTHITTSTEASCSPTTTEGTS 795

Query: 802  TP-NKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQM 860
             P + PS               GSP+  T  P           ST +  P  SN+     
Sbjct: 796  MPISTPSE--------------GSPLL-TSIPVSITPVTSPEASTLSTTPVDSNSPVTTS 840

Query: 861  DDLFDILIKSGEISLP---IKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVS 917
             ++      +   S+P     E  +P++ M   T  + T  ++T+ + P   V  + PV+
Sbjct: 841  TEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTP---VDTSTPVT 897

Query: 918  LEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHSGMLD 977
                        N  EA    T      + P  +  E   P + + D    ++S S    
Sbjct: 898  ------------NSTEARSSPTTSEGTSM-PTSTPGEGSTPLTSMPDSTTPVVS-SEART 943

Query: 978  HSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSSGLTPLSTTAPS 1032
             S +P++TS       TP  +   + S+    E   I     S G TPL++T  S
Sbjct: 944  LSATPVDTS-------TPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVS 991



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 75/397 (18%), Positives = 139/397 (35%), Gaps = 59/397 (14%)

Query: 192  SDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVS-PTVPEFLKTPPTAD 250
            S  +S   P    + G+    S   V+  P   T + P+ + S+S  T  E   +P T +
Sbjct: 3740 STTMSVSMPMEISTLGTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLE 3799

Query: 251  QPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIP 310
                 P +     +T+ +      L+      +P++                       P
Sbjct: 3800 GTTTMPMSTTSERSTLLTT----VLISPISVMSPSEASTLST-----------------P 3838

Query: 311  PDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSG 370
            P   G+ + P + S  A           ++I    ++     T+L +   P +   ++  
Sbjct: 3839 P---GDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASIA 3895

Query: 371  NSA-LNNATPNTPRQNTSTPVRKPGPLPSSLDDL-KVSELKTELKLRGLPVSGTKPDLIE 428
            ++  L+ +T  TP  +T++    P     S+  + + S   T + +   PV+ +  D+  
Sbjct: 3896 STPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTADVFP 3955

Query: 429  RLK--------PYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVT------------ 468
                          E+N+   ++       S+    + P +T A P+T            
Sbjct: 3956 ATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPR 4015

Query: 469  TLHNTVTSSVSTLKA-ELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFT 527
            T     T+S STL A   P T TS  TR        P++PS       +     +  TF 
Sbjct: 4016 TTSRGCTTSASTLSATSTPHTSTSVTTR--------PVTPSSESSRPSTITSHTIPPTFP 4067

Query: 528  EIMTMMSPSQFLSS---SPLRMTNNEDSLSPTSSTLS 561
               +   P+   SS   +P  +T       P++ T S
Sbjct: 4068 PAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTS 4104



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 189  EDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPT 248
            E SS   +    ++  +   A++PS P V  S +PVTT+T    ++ +PT PE +  P +
Sbjct: 3573 EGSSSLTTMLLSSTYVTSSEASTPSTPSVDRS-TPVTTSTQ---SNSTPTPPEVITLPMS 3628

Query: 249  ADQPPPRPAAPVLPTNTVS 267
                   P   ++P +T S
Sbjct: 3629 TPSEVSTPLT-IMPVSTTS 3646


>gi|195963410 MEF2 activating motif and SAP domain containing
           transcriptional regulator isoform 1 [Homo sapiens]
          Length = 415

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 34/184 (18%)

Query: 256 PAAPVLPTNTVSSA-KPGPALVKQSH------PKNPNDKHRSKKCKDPKPRVKKLKYHQY 308
           P AP LP+ T      PG  L +  +      PK  + K  S++ ++ KPR   L YHQY
Sbjct: 46  PLAPALPSGTAPFLFSPGVLLPEPEYCPPWRSPKKESPKI-SQRWRESKPR-GNLTYHQY 103

Query: 309 IPPD-QKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNS 367
           +PP+ ++G + +PQ + +    L      L     SQQ     +  + P+P  P      
Sbjct: 104 MPPEPRQGSRADPQAEGS---ALGPPGPSLWEGTDSQQP----HPRMKPSPLTP------ 150

Query: 368 NSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLI 427
                      P  P  + S P  K       L++L VSEL+ +L+LRGLPVSGTK  L+
Sbjct: 151 ---------CPPGVP--SPSPPPHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKSMLL 199

Query: 428 ERLK 431
           ER++
Sbjct: 200 ERMR 203



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 26/77 (33%), Positives = 34/77 (44%), Gaps = 3/77 (3%)

Query: 199 QPASQESQGSAASPS-EPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPA 257
           +P  ++S   A  P  +PK   +     +  P+  AS  P +P    TP TA  P P PA
Sbjct: 213 KPRREDSPAGAPWPRLKPKALAAARRQGSVKPSA-ASHRPPLPRAADTPGTAPAPTPTPA 271

Query: 258 APVLPTNTVSSAKPGPA 274
               P  T SS  PG A
Sbjct: 272 PAAAPALTPSSG-PGSA 287


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 110/491 (22%), Positives = 190/491 (38%), Gaps = 61/491 (12%)

Query: 576  EKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLG 635
            + ++QI++ +++L++  +L    + Q + +++ QQQ+ L+AQP  P       Q      
Sbjct: 226  QNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQP--PIQQPPMQQPQPPPS 283

Query: 636  SSIKDEASLPDCSSSRQPIPVASH---AVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQ 692
             ++  +      +   QP P       A  QP     Q+    + +V + +   GQ    
Sbjct: 284  QALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQS--QTQPLVSQAQALPGQMLYT 341

Query: 693  SVVSQFYTSPQAGMQ--TQPQI-ATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQV 749
                +F  +P    Q   QPQ+      + TA  A  +AP V  +Q + P  +LS P   
Sbjct: 342  QPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLP--MLSSPSPG 399

Query: 750  RKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSP 809
            ++V T  +     +P    P+P   QP  +   NS + S  AP PS      +P    SP
Sbjct: 400  QQVQTPQS-----MPPPPQPSPQPGQP--SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSP 452

Query: 810  -------------PPPQQFVVQHSLFGSPVAKTK-DPPRYEEAIKQTRSTQAPLPEISNA 855
                         P P    V  S   SP   ++ +  +Y + +KQ      PL  + N 
Sbjct: 453  VTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINK 512

Query: 856  HSQQMDDLFDILIKSGEISLPIKEEPS---PISKMRPVTASITTMPVNTVVSRPPPQVQM 912
              +  D   D  +   +  L I  +PS   P+  ++    ++  +  +  V  PPP    
Sbjct: 513  IDKNEDRKKD--LSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPP--PP 568

Query: 913  APPVSLEPMGS--LSASLENQLEAFLDGTL-----PSANEI--PPL--------QSSSED 955
             PP   + +    L A L N      + +L     P+   I  PP+        +   ED
Sbjct: 569  VPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLED 628

Query: 956  REPFSLIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDIT 1015
             E  S+   LQ ++         +  P   S      GT  L   L D +L ++  L+++
Sbjct: 629  DERQSIPSVLQGEVARLDPKFLVNLDPSHCSNN----GTVHLICKLDDKDLPSVPPLELS 684

Query: 1016 MPNSSSGLTPL 1026
            +P      +PL
Sbjct: 685  VPADYPAQSPL 695



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 73/336 (21%), Positives = 118/336 (35%), Gaps = 55/336 (16%)

Query: 317 KNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNN 376
           +N+ Q+     +L +  QL LQ Q   QQ+Q    Q  L A   P+            + 
Sbjct: 226 QNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQ-PPIQQPPMQQPQPPPSQ 284

Query: 377 ATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEV 436
           A P   +Q   T   +P P P                    PV+  +P  +      Q +
Sbjct: 285 ALPQQLQQMHHTQHHQPPPQPQQP-----------------PVAQNQPSQLPPQSQTQPL 327

Query: 437 NSSGLAAGGIVAVSS-------SAIVTSNPEVT-------VALPVTTLHNTVTSSVSTLK 482
            S   A  G +  +        + +V   P V         A+        V   V   +
Sbjct: 328 VSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQ 387

Query: 483 AELP----PTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQF 538
           + LP    P+        +++  P   SP P + SS    + +     +    + SPS  
Sbjct: 388 SSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQ 447

Query: 539 LSSSPL--RMTNNEDSLSP--------TSSTLSNLELDAAEKDR---KLQEKEKQIEELK 585
            S SP+  R   N    SP         SS +S      AE+ +   KL++  K IE L+
Sbjct: 448 PSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLR 507

Query: 586 R------KLEQEQKLVEVLKMQLEVEKRGQQQRPLE 615
           R      K E  +K +  +K  L++     ++ PL+
Sbjct: 508 RMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLK 543



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 50/223 (22%), Positives = 80/223 (35%), Gaps = 45/223 (20%)

Query: 23  PQSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFH 82
           P S+A+  + Q++        PP  ++  V Q +  Q            +PP        
Sbjct: 281 PPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQ------------LPPQSQTQPLV 328

Query: 83  EQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLN 142
            Q ++L            + ++P    +    ++++   +P +Q  Q  ++ A+ A    
Sbjct: 329 SQAQALPG--------QMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAA---- 376

Query: 143 EKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPAS 202
               Q   P   V ++ LP+ SS                Q   S       +  P QP+S
Sbjct: 377 ----QMVAPGVQVSQSSLPMLSSPSPG---------QQVQTPQSMPPPPQPSPQPGQPSS 423

Query: 203 QE----SQGSAASPS----EPKVSESPSPVTTNTPAQFASVSP 237
           Q     S G A SPS     P    S SPVT  TP  F+  SP
Sbjct: 424 QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSP 466



 Score = 30.8 bits (68), Expect = 7.0
 Identities = 51/260 (19%), Positives = 104/260 (40%), Gaps = 24/260 (9%)

Query: 24  QSEAVAHEFQELSLQSSQNLPPLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHE 83
           Q  A+  +FQ +  Q  Q      +++++++L  Q ++  +Q   Q     L+  A    
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQ-----LQRIAQLQL 246

Query: 84  QIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNE 143
           Q +  ++ + +   +  ++++P     ++   +++    PS QA   +L++         
Sbjct: 247 QQQQQQQQQQQQQQQQALQAQPP----IQQPPMQQPQPPPS-QALPQQLQQMHHTQHHQP 301

Query: 144 KIAQRPGPMELVEKNILPVDSS----VKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPD- 198
               +  P+   + + LP  S     V +A    G+  Y  TQ    F         P  
Sbjct: 302 PPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLY--TQPPLKFVRAPMVVQQPPV 359

Query: 199 QPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSP----TVPEFLKTPPTADQPPP 254
           QP  Q+ Q +  +    ++      V+ ++    +S SP      P+ +  PP   QP P
Sbjct: 360 QPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPP---QPSP 416

Query: 255 RPAAPVLPTNTVSSAKPGPA 274
           +P  P    N+  S+ P P+
Sbjct: 417 QPGQPSSQPNSNVSSGPAPS 436


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 160/776 (20%), Positives = 265/776 (34%), Gaps = 120/776 (15%)

Query: 196  SPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPR 255
            +P +P +Q+     + P   K    PS +T     Q  +V P V      PP   +PP +
Sbjct: 310  TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQ-----PPGTTKPPAQ 364

Query: 256  PAAPVLP------TNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRV---KKLKYH 306
            P  P  P      +   SS +PGP  + Q          +    K P  +V   K L   
Sbjct: 365  PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQ 424

Query: 307  QYI--PPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLND 364
              +  P    G    P       ++  QQ      +  +QQ       + LP P KP   
Sbjct: 425  PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAG--PGKTSAQQTGPTKPPSQLPGPAKPPPQ 482

Query: 365  KNSNSGNSALNNATPNTPRQ---NTSTPVRKPGPLPSSLDD----LKVSELKTELKLRGL 417
            +   +        +   P Q   +T  P ++PGP   S          S+     K    
Sbjct: 483  QPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQ 542

Query: 418  PVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSS-----------AIVTSNPEVTVALP 466
              S  KP   +  KP  +  S        V+ S+              + +  E+ + +P
Sbjct: 543  QPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVP 602

Query: 467  VTTLHNTVTSSVSTLKAELPPTGTSNATRVENVH--------------SPLPISPSPSEQ 512
                 NT T   +T+ +        + T V+                 +P+P SP P  +
Sbjct: 603  EKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLK 662

Query: 513  SSLSTDDTNMADTF-----TEIMTMMSPSQFLSSSPLRMTN----NEDSL--SPTSSTLS 561
            ++  T  + ++ +      T      +P Q LS +P          + +L  SP++    
Sbjct: 663  TAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQ 722

Query: 562  NLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAP 621
              E D+  K    +E     E+ K  +  ++             K+ +  +P     S+ 
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKP------------KQPKMVKPTTDLVSSS 770

Query: 622  GHSVKSDQKHGSLGSSIKDEASLP---DCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAV 678
              + K D     + S  +++ + P   D +   Q  P     V  P  +      A  + 
Sbjct: 771  SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVS-PFDSKAIPRPASDSK 829

Query: 679  VIKQEVPVGQAEQQSVVS--QFYTSPQAGMQTQPQIATAAQIPTAA-LASGLAPTVPQTQ 735
            +I    P  +++ Q  V   Q    P+           A  +P  +    G  PT  QT 
Sbjct: 830  IISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTV 889

Query: 736  DTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAP---------AVQQPFINKASNSVL 786
             T  Q    +PQ+  + F+ +  S T  P  +   P                ++ASN ++
Sbjct: 890  PTPQQS--PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASN-LI 946

Query: 787  QSRNAPLPSLQNGPNTPNK----PSSPP----PPQQF--VVQHSLFGSPVAK-TKDP--- 832
             +   P P  Q+GP  P K    PS PP    PP+             PV K TK P   
Sbjct: 947  STAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAE 1006

Query: 833  ---PRYEEA--IKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSP 883
               P+ E+A  +K+T + + P P         + D   +  +  +  LP K E SP
Sbjct: 1007 KLEPKAEQAPTVKRTETEKKPPP---------IKDSKSLTAEPQKAVLPTKLEKSP 1053



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 97/465 (20%), Positives = 171/465 (36%), Gaps = 68/465 (14%)

Query: 211  SPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVL---PTNTVS 267
            +PS PK S  P PV T + +Q  +V P V    K     +Q     A  V+      T+S
Sbjct: 1128 APSGPKAS--PMPVPTESSSQKTAVPPQV----KLVKKQEQEVKTEAEKVILEKVKETLS 1181

Query: 268  SAKPGPALV---KQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQK--GEKNEPQM 322
              K  P +    KQ   K   DK  + + K P P  KKL     IP ++K   E+ +P +
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKL-----IPEEEKIRSEEKKPLL 1236

Query: 323  DSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTP 382
            +       + ++L  + +  + ++Q ++   +L +  +   +K             P T 
Sbjct: 1237 EEKKPTP-EDKKLLPEAKTSAPEEQKHD---LLKSQVQIAEEKLEG-------RVAPKTV 1285

Query: 383  RQNTSTPVRK---PGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKP------- 432
            ++      +    P   P SL        KT +K +  P    KPD +E  K        
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAKPDQVEPGKEKTEKEDD 1344

Query: 433  -------YQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAEL 485
                    Q  +  GL+  G    SS  I +S  E+   +P             +   E 
Sbjct: 1345 KSDTSSSQQPKSPQGLSDTGY---SSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQES 1401

Query: 486  PPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLR 545
             P+  S+  ++E+           +  S L    + +AD  +E  T   P +     P  
Sbjct: 1402 SPSSPSDLAKLES-----------TVLSILEAQASTLADEKSEKKTQ--PHEVSPEQPKD 1448

Query: 546  MTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVE 605
                +        T+S  E+  ++++RK   K+   +++    + ++K   V     ++ 
Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVD----DIT 1504

Query: 606  KRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSS 650
             R +    +E    +    V   ++  S+GSS  DE    D   S
Sbjct: 1505 TRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGS 1549



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 78/340 (22%), Positives = 120/340 (35%), Gaps = 69/340 (20%)

Query: 609 QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEA-SLPDCSSSRQPI-----------PV 656
           QQ  P +  P  PG +    Q+ GS   S +  + + P    S +P+           P 
Sbjct: 512 QQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT 571

Query: 657 ASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTS--PQAGMQTQPQIAT 714
            S +  QP S G    +       +  + V +    +  ++  T+     G    P +  
Sbjct: 572 VSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTE 631

Query: 715 AAQI------PTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRH 768
             +          AL   LAP VP +    PQ  L    +   V T SA S +       
Sbjct: 632 VKEWLCLNCQMKRALGGDLAP-VPSS----PQPKL----KTAPVTTTSAVSKS------- 675

Query: 769 PAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAK 828
            +P  QQ    K +        AP   L   P    +P  PPP    V Q +L GSP AK
Sbjct: 676 -SPQPQQTSPKKDA--------APKQDLSKAP----EPKKPPP---LVKQPTLHGSPSAK 719

Query: 829 TKDPPRYEEAIK---------QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKE 879
            K PP  +   K          +   +AP+ +      + +    D++  S   + P   
Sbjct: 720 AKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKP--- 776

Query: 880 EPSPISKMRPVTASITTMPVNTVVSRP----PPQVQMAPP 915
              P SK++      TT P+ T  ++P    PP  +   P
Sbjct: 777 -DIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP 815



 Score = 37.0 bits (84), Expect = 0.097
 Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 8/81 (9%)

Query: 191  SSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTAD 250
            S +    ++PASQ   GS   PS   +   P P   ++    ++  P  P     PP   
Sbjct: 2363 SGETFGQEKPASQLPSGS---PSVSSLPAKPRPFFRSSSLDISAQPPPPPP---PPPPPP 2416

Query: 251  QPPPRPAAPVLPTNTVSSAKP 271
             PPP P  P LP  T  S KP
Sbjct: 2417 PPPPPPPPPPLPPPT--SPKP 2435



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 175/922 (18%), Positives = 291/922 (31%), Gaps = 171/922 (18%)

Query: 209  AASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS 268
            A  PS P+     +PVTT +     +VS + P+  +T P  D      AAP    +    
Sbjct: 651  APVPSSPQPKLKTAPVTTTS-----AVSKSSPQPQQTSPKKD------AAPKQDLSKAPE 699

Query: 269  AKPGPALVKQ------SHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQM 322
             K  P LVKQ         K           K   P+   +   Q   P    +  +P+M
Sbjct: 700  PKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759

Query: 323  DSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATP--- 379
                  L+       +  I S + Q    +   P P K  + K S S        +P   
Sbjct: 760  VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-PLKTDSAKPSQSFPPTGEKVSPFDS 818

Query: 380  -NTPR-QNTSTPVRKPGPLPSSLDDLKVSEL-------KTELKLRGLP------------ 418
               PR  + S  +  PGP   S    +V  +       K + K+   P            
Sbjct: 819  KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTP 878

Query: 419  ------VSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHN 472
                     T P   +  KP ++     L  G I     S   T  P+ TV   +     
Sbjct: 879  PGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT--PQETVTGKLFGFGA 936

Query: 473  TVTSSVSTL--KAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIM 530
            ++ S  S L   A  P   + +        +P P  P  S+    ST     A       
Sbjct: 937  SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA------- 989

Query: 531  TMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAE------KDRKLQEKEKQIEEL 584
                P++ +           + L P +     ++    E      KD K    E Q   L
Sbjct: 990  ----PAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVL 1045

Query: 585  KRKLEQEQK---LVEVLKMQLEV------------EKRGQQQRPLEAQPSAPGHSVK--- 626
              KLE+  K      + K +L +            E + Q        P+     ++   
Sbjct: 1046 PTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWL 1105

Query: 627  --SDQKHGSLGSSIKDEASLPDCSS--SRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQ 682
              + Q   ++   + D   +P   S     P+PV + +  Q  +   Q  + KK    +Q
Sbjct: 1106 CLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ---EQ 1162

Query: 683  EVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPT------VPQTQD 736
            EV   + E + V+ +      +  +  P + T  +   + L    A        +P+ + 
Sbjct: 1163 EV---KTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219

Query: 737  TFPQHVLSQPQQVRKVFTN---SASSNTVLPYQRHPAPAVQQPFINKASNSV----LQSR 789
              P+    + ++ + +      +     +LP  +  AP  Q+  + K+   +    L+ R
Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279

Query: 790  NAPLPSLQNGPNTPNKPSSPP--PPQQFVVQHSLFGSPVAKTKDPP-------------- 833
             AP  ++Q G     K    P   PQ    +       + +   PP              
Sbjct: 1280 VAP-KTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK 1338

Query: 834  -RYEEAIKQTRSTQAP-------------------LPEISNAHSQQMDDLFDILIKSGEI 873
               E+    T S+Q P                   L EI +       D+   L K    
Sbjct: 1339 TEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFS 1398

Query: 874  SLPIKEEPSPISKMRPVTASITTMPVNTVVSR------PPPQVQMAPPVSLEPMGSLSAS 927
                   PS ++K+     SI     +T+          P +V    P   E   SLS +
Sbjct: 1399 QESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSET 1458

Query: 928  L----------ENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQN-----DLLSH 972
            L          E+Q E        S  +IP   SS + +E    ++D+       D +  
Sbjct: 1459 LEITISEEEIKESQEERKDTFKKDSQQDIP---SSKDHKEKSEFVDDITTRREPYDSVEE 1515

Query: 973  SGMLDHSHSPMETSETQFAAGT 994
            S   ++S  P     T   + +
Sbjct: 1516 SSESENSPVPQRKRRTSVGSSS 1537



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 109/534 (20%), Positives = 181/534 (33%), Gaps = 112/534 (20%)

Query: 179  PHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPT 238
            P +QG       +  A +   P  +E++  AA   EPK  ++P+   T T          
Sbjct: 974  PTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEK-------- 1025

Query: 239  VPEFLKTPPTADQP--PPRPAAPVLPTNTVSSAKPGPA--LVKQS---HPKNPNDKHRSK 291
                 K PP  D       P   VLPT    S KP     L K       K+P + +   
Sbjct: 1026 -----KPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCT 1080

Query: 292  KCK---------DPKPRVKKLKYH------------------QYIPPDQKGEKNEPQMDS 324
            +CK         +P P + +++                    + +PP   G K  P M  
Sbjct: 1081 ECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASP-MPV 1139

Query: 325  NYARLLQQQQLFLQLQILSQQKQHYNYQ---TILPAPFKPLNDKNSNSGNSALNNATPNT 381
                  Q+  +  Q++++ +Q+Q    +    IL    + L+ +      +       + 
Sbjct: 1140 PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESK 1199

Query: 382  PRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGL 441
              ++ ++ +++  PLP   ++ K+  +  E K+R    S  K  L+E  KP  E      
Sbjct: 1200 LEKDKASALQEKKPLP---EEKKL--IPEEEKIR----SEEKKPLLEEKKPTPEDKK--- 1247

Query: 442  AAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAEL-----PPT---GTSNA 493
                             PE   + P    H+ + S V   + +L     P T   G    
Sbjct: 1248 ---------------LLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQ 1292

Query: 494  TRVENVHSPLPIS---------------PSP-----SEQSSLSTDDTNMADTFTEIMTMM 533
            T++E + S  P S               P P      +Q     + T   D  ++  +  
Sbjct: 1293 TKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQ 1352

Query: 534  SPS--QFLSSSPLRMTNNEDSLSPTSSTLSNLELD---AAEKDRKLQEKEKQIEELKRKL 588
             P   Q LS +         SL    S +   E D     +KD   QE          KL
Sbjct: 1353 QPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKL 1412

Query: 589  EQE-QKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDE 641
            E     ++E     L  EK  ++ +P E  P  P    K+     +L  +I +E
Sbjct: 1413 ESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEE 1466



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 43/157 (27%), Positives = 62/157 (39%), Gaps = 23/157 (14%)

Query: 146 AQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQES 205
           A+ PGP +   +   P     ++A  G GK     T       +  S    P +P  Q+ 
Sbjct: 431 AKAPGPTKTPVQQPGPGKIPAQQA--GPGKTSAQQTGPT----KPPSQLPGPAKPPPQQP 484

Query: 206 QGSAASPSEPKVSESPS--PVTTNTPAQF---ASVSPTVPEFLKTP--------PTADQP 252
             +   P +P  ++ PS  P +T  P Q    A  SP  P   K P        P+A QP
Sbjct: 485 GPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 544

Query: 253 -PPRPAA--PVLPTNTVSSAKP-GPALVKQSHPKNPN 285
            P +P+A     P +   S KP  P  V  S  + P+
Sbjct: 545 SPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPS 581


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 160/776 (20%), Positives = 265/776 (34%), Gaps = 120/776 (15%)

Query: 196  SPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPR 255
            +P +P +Q+     + P   K    PS +T     Q  +V P V      PP   +PP +
Sbjct: 310  TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQ-----PPGTTKPPAQ 364

Query: 256  PAAPVLP------TNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRV---KKLKYH 306
            P  P  P      +   SS +PGP  + Q          +    K P  +V   K L   
Sbjct: 365  PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQ 424

Query: 307  QYI--PPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLND 364
              +  P    G    P       ++  QQ      +  +QQ       + LP P KP   
Sbjct: 425  PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAG--PGKTSAQQTGPTKPPSQLPGPAKPPPQ 482

Query: 365  KNSNSGNSALNNATPNTPRQ---NTSTPVRKPGPLPSSLDD----LKVSELKTELKLRGL 417
            +   +        +   P Q   +T  P ++PGP   S          S+     K    
Sbjct: 483  QPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQ 542

Query: 418  PVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSS-----------AIVTSNPEVTVALP 466
              S  KP   +  KP  +  S        V+ S+              + +  E+ + +P
Sbjct: 543  QPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVP 602

Query: 467  VTTLHNTVTSSVSTLKAELPPTGTSNATRVENVH--------------SPLPISPSPSEQ 512
                 NT T   +T+ +        + T V+                 +P+P SP P  +
Sbjct: 603  EKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLK 662

Query: 513  SSLSTDDTNMADTF-----TEIMTMMSPSQFLSSSPLRMTN----NEDSL--SPTSSTLS 561
            ++  T  + ++ +      T      +P Q LS +P          + +L  SP++    
Sbjct: 663  TAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQ 722

Query: 562  NLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAP 621
              E D+  K    +E     E+ K  +  ++             K+ +  +P     S+ 
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKP------------KQPKMVKPTTDLVSSS 770

Query: 622  GHSVKSDQKHGSLGSSIKDEASLP---DCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAV 678
              + K D     + S  +++ + P   D +   Q  P     V  P  +      A  + 
Sbjct: 771  SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVS-PFDSKAIPRPASDSK 829

Query: 679  VIKQEVPVGQAEQQSVVS--QFYTSPQAGMQTQPQIATAAQIPTAA-LASGLAPTVPQTQ 735
            +I    P  +++ Q  V   Q    P+           A  +P  +    G  PT  QT 
Sbjct: 830  IISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTV 889

Query: 736  DTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAP---------AVQQPFINKASNSVL 786
             T  Q    +PQ+  + F+ +  S T  P  +   P                ++ASN ++
Sbjct: 890  PTPQQS--PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASN-LI 946

Query: 787  QSRNAPLPSLQNGPNTPNK----PSSPP----PPQQF--VVQHSLFGSPVAK-TKDP--- 832
             +   P P  Q+GP  P K    PS PP    PP+             PV K TK P   
Sbjct: 947  STAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAE 1006

Query: 833  ---PRYEEA--IKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSP 883
               P+ E+A  +K+T + + P P         + D   +  +  +  LP K E SP
Sbjct: 1007 KLEPKAEQAPTVKRTETEKKPPP---------IKDSKSLTAEPQKAVLPTKLEKSP 1053



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 97/465 (20%), Positives = 171/465 (36%), Gaps = 68/465 (14%)

Query: 211  SPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVL---PTNTVS 267
            +PS PK S  P PV T + +Q  +V P V    K     +Q     A  V+      T+S
Sbjct: 1128 APSGPKAS--PMPVPTESSSQKTAVPPQV----KLVKKQEQEVKTEAEKVILEKVKETLS 1181

Query: 268  SAKPGPALV---KQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQK--GEKNEPQM 322
              K  P +    KQ   K   DK  + + K P P  KKL     IP ++K   E+ +P +
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKL-----IPEEEKIRSEEKKPLL 1236

Query: 323  DSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTP 382
            +       + ++L  + +  + ++Q ++   +L +  +   +K             P T 
Sbjct: 1237 EEKKPTP-EDKKLLPEAKTSAPEEQKHD---LLKSQVQIAEEKLEG-------RVAPKTV 1285

Query: 383  RQNTSTPVRK---PGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKP------- 432
            ++      +    P   P SL        KT +K +  P    KPD +E  K        
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAKPDQVEPGKEKTEKEDD 1344

Query: 433  -------YQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAEL 485
                    Q  +  GL+  G    SS  I +S  E+   +P             +   E 
Sbjct: 1345 KSDTSSSQQPKSPQGLSDTGY---SSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQES 1401

Query: 486  PPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLR 545
             P+  S+  ++E+           +  S L    + +AD  +E  T   P +     P  
Sbjct: 1402 SPSSPSDLAKLES-----------TVLSILEAQASTLADEKSEKKTQ--PHEVSPEQPKD 1448

Query: 546  MTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVE 605
                +        T+S  E+  ++++RK   K+   +++    + ++K   V     ++ 
Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVD----DIT 1504

Query: 606  KRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSS 650
             R +    +E    +    V   ++  S+GSS  DE    D   S
Sbjct: 1505 TRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGS 1549



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 78/340 (22%), Positives = 120/340 (35%), Gaps = 69/340 (20%)

Query: 609 QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEA-SLPDCSSSRQPI-----------PV 656
           QQ  P +  P  PG +    Q+ GS   S +  + + P    S +P+           P 
Sbjct: 512 QQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT 571

Query: 657 ASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTS--PQAGMQTQPQIAT 714
            S +  QP S G    +       +  + V +    +  ++  T+     G    P +  
Sbjct: 572 VSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTE 631

Query: 715 AAQI------PTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRH 768
             +          AL   LAP VP +    PQ  L    +   V T SA S +       
Sbjct: 632 VKEWLCLNCQMKRALGGDLAP-VPSS----PQPKL----KTAPVTTTSAVSKS------- 675

Query: 769 PAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAK 828
            +P  QQ    K +        AP   L   P    +P  PPP    V Q +L GSP AK
Sbjct: 676 -SPQPQQTSPKKDA--------APKQDLSKAP----EPKKPPP---LVKQPTLHGSPSAK 719

Query: 829 TKDPPRYEEAIK---------QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKE 879
            K PP  +   K          +   +AP+ +      + +    D++  S   + P   
Sbjct: 720 AKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKP--- 776

Query: 880 EPSPISKMRPVTASITTMPVNTVVSRP----PPQVQMAPP 915
              P SK++      TT P+ T  ++P    PP  +   P
Sbjct: 777 -DIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP 815



 Score = 37.0 bits (84), Expect = 0.097
 Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 8/81 (9%)

Query: 191  SSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTAD 250
            S +    ++PASQ   GS   PS   +   P P   ++    ++  P  P     PP   
Sbjct: 2363 SGETFGQEKPASQLPSGS---PSVSSLPAKPRPFFRSSSLDISAQPPPPPP---PPPPPP 2416

Query: 251  QPPPRPAAPVLPTNTVSSAKP 271
             PPP P  P LP  T  S KP
Sbjct: 2417 PPPPPPPPPPLPPPT--SPKP 2435



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 175/922 (18%), Positives = 291/922 (31%), Gaps = 171/922 (18%)

Query: 209  AASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS 268
            A  PS P+     +PVTT +     +VS + P+  +T P  D      AAP    +    
Sbjct: 651  APVPSSPQPKLKTAPVTTTS-----AVSKSSPQPQQTSPKKD------AAPKQDLSKAPE 699

Query: 269  AKPGPALVKQ------SHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQM 322
             K  P LVKQ         K           K   P+   +   Q   P    +  +P+M
Sbjct: 700  PKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759

Query: 323  DSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATP--- 379
                  L+       +  I S + Q    +   P P K  + K S S        +P   
Sbjct: 760  VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-PLKTDSAKPSQSFPPTGEKVSPFDS 818

Query: 380  -NTPR-QNTSTPVRKPGPLPSSLDDLKVSEL-------KTELKLRGLP------------ 418
               PR  + S  +  PGP   S    +V  +       K + K+   P            
Sbjct: 819  KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTP 878

Query: 419  ------VSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHN 472
                     T P   +  KP ++     L  G I     S   T  P+ TV   +     
Sbjct: 879  PGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT--PQETVTGKLFGFGA 936

Query: 473  TVTSSVSTL--KAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIM 530
            ++ S  S L   A  P   + +        +P P  P  S+    ST     A       
Sbjct: 937  SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA------- 989

Query: 531  TMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAE------KDRKLQEKEKQIEEL 584
                P++ +           + L P +     ++    E      KD K    E Q   L
Sbjct: 990  ----PAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVL 1045

Query: 585  KRKLEQEQK---LVEVLKMQLEV------------EKRGQQQRPLEAQPSAPGHSVK--- 626
              KLE+  K      + K +L +            E + Q        P+     ++   
Sbjct: 1046 PTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWL 1105

Query: 627  --SDQKHGSLGSSIKDEASLPDCSS--SRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQ 682
              + Q   ++   + D   +P   S     P+PV + +  Q  +   Q  + KK    +Q
Sbjct: 1106 CLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ---EQ 1162

Query: 683  EVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPT------VPQTQD 736
            EV   + E + V+ +      +  +  P + T  +   + L    A        +P+ + 
Sbjct: 1163 EV---KTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219

Query: 737  TFPQHVLSQPQQVRKVFTN---SASSNTVLPYQRHPAPAVQQPFINKASNSV----LQSR 789
              P+    + ++ + +      +     +LP  +  AP  Q+  + K+   +    L+ R
Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279

Query: 790  NAPLPSLQNGPNTPNKPSSPP--PPQQFVVQHSLFGSPVAKTKDPP-------------- 833
             AP  ++Q G     K    P   PQ    +       + +   PP              
Sbjct: 1280 VAP-KTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK 1338

Query: 834  -RYEEAIKQTRSTQAP-------------------LPEISNAHSQQMDDLFDILIKSGEI 873
               E+    T S+Q P                   L EI +       D+   L K    
Sbjct: 1339 TEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFS 1398

Query: 874  SLPIKEEPSPISKMRPVTASITTMPVNTVVSR------PPPQVQMAPPVSLEPMGSLSAS 927
                   PS ++K+     SI     +T+          P +V    P   E   SLS +
Sbjct: 1399 QESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSET 1458

Query: 928  L----------ENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQN-----DLLSH 972
            L          E+Q E        S  +IP   SS + +E    ++D+       D +  
Sbjct: 1459 LEITISEEEIKESQEERKDTFKKDSQQDIP---SSKDHKEKSEFVDDITTRREPYDSVEE 1515

Query: 973  SGMLDHSHSPMETSETQFAAGT 994
            S   ++S  P     T   + +
Sbjct: 1516 SSESENSPVPQRKRRTSVGSSS 1537



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 109/534 (20%), Positives = 181/534 (33%), Gaps = 112/534 (20%)

Query: 179  PHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPT 238
            P +QG       +  A +   P  +E++  AA   EPK  ++P+   T T          
Sbjct: 974  PTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEK-------- 1025

Query: 239  VPEFLKTPPTADQP--PPRPAAPVLPTNTVSSAKPGPA--LVKQS---HPKNPNDKHRSK 291
                 K PP  D       P   VLPT    S KP     L K       K+P + +   
Sbjct: 1026 -----KPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCT 1080

Query: 292  KCK---------DPKPRVKKLKYH------------------QYIPPDQKGEKNEPQMDS 324
            +CK         +P P + +++                    + +PP   G K  P M  
Sbjct: 1081 ECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASP-MPV 1139

Query: 325  NYARLLQQQQLFLQLQILSQQKQHYNYQ---TILPAPFKPLNDKNSNSGNSALNNATPNT 381
                  Q+  +  Q++++ +Q+Q    +    IL    + L+ +      +       + 
Sbjct: 1140 PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESK 1199

Query: 382  PRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGL 441
              ++ ++ +++  PLP   ++ K+  +  E K+R    S  K  L+E  KP  E      
Sbjct: 1200 LEKDKASALQEKKPLP---EEKKL--IPEEEKIR----SEEKKPLLEEKKPTPEDKK--- 1247

Query: 442  AAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAEL-----PPT---GTSNA 493
                             PE   + P    H+ + S V   + +L     P T   G    
Sbjct: 1248 ---------------LLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQ 1292

Query: 494  TRVENVHSPLPIS---------------PSP-----SEQSSLSTDDTNMADTFTEIMTMM 533
            T++E + S  P S               P P      +Q     + T   D  ++  +  
Sbjct: 1293 TKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQ 1352

Query: 534  SPS--QFLSSSPLRMTNNEDSLSPTSSTLSNLELD---AAEKDRKLQEKEKQIEELKRKL 588
             P   Q LS +         SL    S +   E D     +KD   QE          KL
Sbjct: 1353 QPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKL 1412

Query: 589  EQE-QKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDE 641
            E     ++E     L  EK  ++ +P E  P  P    K+     +L  +I +E
Sbjct: 1413 ESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEE 1466



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 43/157 (27%), Positives = 62/157 (39%), Gaps = 23/157 (14%)

Query: 146 AQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQES 205
           A+ PGP +   +   P     ++A  G GK     T       +  S    P +P  Q+ 
Sbjct: 431 AKAPGPTKTPVQQPGPGKIPAQQA--GPGKTSAQQTGPT----KPPSQLPGPAKPPPQQP 484

Query: 206 QGSAASPSEPKVSESPS--PVTTNTPAQF---ASVSPTVPEFLKTP--------PTADQP 252
             +   P +P  ++ PS  P +T  P Q    A  SP  P   K P        P+A QP
Sbjct: 485 GPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 544

Query: 253 -PPRPAA--PVLPTNTVSSAKP-GPALVKQSHPKNPN 285
            P +P+A     P +   S KP  P  V  S  + P+
Sbjct: 545 SPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPS 581


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 138/698 (19%), Positives = 207/698 (29%), Gaps = 134/698 (19%)

Query: 174 GKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFA 233
           GKE     +   S ++ S+  L+P      +    A + ++     +P   T  TP + A
Sbjct: 166 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 225

Query: 234 SVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS----AKPGPALVKQSHPKNPNDKHR 289
           S +P  P    TP T    P  P  P  PT T S+     +P P   K+  P  P     
Sbjct: 226 STTPKEP----TPTTIKSAPTTPKEPA-PTTTKSAPTTPKEPAPTTTKEPAPTTP----- 275

Query: 290 SKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHY 349
               K+P P   K        P     K+ P      A    ++                
Sbjct: 276 ----KEPAPTTTK-------EPAPTTTKSAPTTPKEPAPTTPKK---------------- 308

Query: 350 NYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELK 409
                 PAP  P                 P TP++ T T  ++P P           E  
Sbjct: 309 ------PAPTTP-------------KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 349

Query: 410 TELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTT 469
                +  P +  +P      +P                 S +      P  T + P TT
Sbjct: 350 PTAPKKPAPTTPKEPAPTTPKEPAPTTTKE---------PSPTTPKEPAPTTTKSAPTTT 400

Query: 470 LH--NTVTSSVSTLKAELPPTGTSN--ATRVENVHSPLPISPSP-SEQSSLSTDDTNMAD 524
                T T S  T   E  PT T     T  +      P  P+P + +    T     A 
Sbjct: 401 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 460

Query: 525 TFTEIMTMMSPSQFLSSSPLRMT-NNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEE 583
           T T+     +P +   ++P          L+PT  T   L     EK           EE
Sbjct: 461 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EE 513

Query: 584 LKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEAS 643
           L     +E       +      K      P E  P+ P                      
Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------------------- 553

Query: 644 LPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQ 703
            P  ++ ++P P        P  T   T        +K+  P              T+P+
Sbjct: 554 -PAPTTPKEPAPTT------PKETAPTTPKGTAPTTLKEPAP--------------TTPK 592

Query: 704 --AGMQTQPQIATAAQIPTAALASGLAPTVPQ-TQDTFPQHVLSQPQQVRKVFTNSASSN 760
             A  +  P   T  + PT+      APT P+ T  T P+       +     T   ++ 
Sbjct: 593 KPAPKELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 649

Query: 761 TVL-----PYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQF 815
           T L        + PAP    P   K   S    + AP    +  P TP +P+   P +  
Sbjct: 650 TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 709

Query: 816 VVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEIS 853
                      ++   P   +E     +S     PE+S
Sbjct: 710 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 747



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 132/707 (18%), Positives = 222/707 (31%), Gaps = 106/707 (14%)

Query: 161 PVDSSVKEAIIGVGKEDYPHTQGDFS--FDEDSSDALSPDQPASQESQGSAASPSEPKVS 218
           P  ++ KE      KE  P T  + S    ++ +   +   P + +      + S P   
Sbjct: 356 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 415

Query: 219 ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
           + PSP TT  PA      PT P   K P       P P  P  P  T +  +P P   K+
Sbjct: 416 KEPSPTTTKEPA------PTTP---KEPAPTTPKKPAPTTPKEPAPT-TPKEPAPTTTKK 465

Query: 279 SHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQ 338
             P  P         K+P P   K    +  P   K  K  P      A    ++     
Sbjct: 466 PAPTTP---------KEPAPTTPK----ETAPTTPK--KLTPTTPEKLAPTTPEKPAPTT 510

Query: 339 LQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPS 398
            + L+              P +P          +    A PNTP++   T  ++P P   
Sbjct: 511 PEELAP-----------TTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP 559

Query: 399 SLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSN 458
                K     T  +       GT P  ++   P      +            ++     
Sbjct: 560 -----KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 614

Query: 459 PEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTD 518
           P  T   P  T   T      T   E  PT T   T    +  P P +P       L+  
Sbjct: 615 PAPTT--PKGTAPTTPKEPAPTTPKEPAPT-TPKGTAPTTLKEPAPTTPKKPAPKELAPT 671

Query: 519 DTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKE 578
            T              P+   S  P   T  E     T+ T          K     +  
Sbjct: 672 TTK------------GPTSTTSDKPAPTTPKE-----TAPTTPKEPAPTTPK-----KPA 709

Query: 579 KQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRP-LEAQPSAPGHSVKSDQKHGSLGSS 637
               E       E       K    + K   +  P L A+P+    ++++  K   + ++
Sbjct: 710 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTP--KALENSPKEPGVPTT 767

Query: 638 IKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQ 697
               A+ P+ +++ +           P +T     + K+              +++  S+
Sbjct: 768 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETAT---------TTEKTTESK 818

Query: 698 FYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTF-PQHVLSQPQQVRKVFTNS 756
              +      T  Q  T  +I T    + LAP V  T+ T     ++++P++  K    +
Sbjct: 819 ITATTTQVTSTTTQDTTPFKITTLKTTT-LAPKVTTTKKTITTTEIMNKPEETAKPKDRA 877

Query: 757 ASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFV 816
            +S    P  + P  A ++P   K   ++ + R               KP + P P++  
Sbjct: 878 TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR---------------KPKTTPTPRKMT 922

Query: 817 VQHSLFGSPVAKTKDPPRYEEAIKQ--TRSTQAPLPEISNAHSQQMD 861
                  S + +     R  EA+ Q  TR  Q P  ++   + +  D
Sbjct: 923 -------STMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSED 962



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 15/144 (10%)

Query: 161 PVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPK--VS 218
           P  ++ KE      KE  P T          S   +P +PA   ++ +  +P EP    +
Sbjct: 216 PTPTTPKEPASTTPKEPTPTTI--------KSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 267

Query: 219 ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
           + P+P T   PA   +  P  P   K+ PT  +  P P  P  P  T +  +P P   K+
Sbjct: 268 KEPAPTTPKEPAPTTTKEP-APTTTKSAPTTPK-EPAPTTPKKPAPT-TPKEPAPTTPKE 324

Query: 279 SHPKNPNDKHRSKKCKDPKPRVKK 302
             P  P  K  +   K+P P   K
Sbjct: 325 PTPTTP--KEPAPTTKEPAPTTPK 346



 Score = 38.1 bits (87), Expect = 0.044
 Identities = 70/321 (21%), Positives = 118/321 (36%), Gaps = 36/321 (11%)

Query: 612 RPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQ- 670
           +P+  +PS P +S  S  K  SL  ++  E ++    ++            +  ST G+ 
Sbjct: 122 KPINPRPSLPPNSDTS--KETSL--TVNKETTVETKETT---------TTNKQTSTDGKE 168

Query: 671 -TLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAP 729
            T  AK+   I++      A    V+++   +P+A   T+    T  + PT       A 
Sbjct: 169 KTTSAKETQSIEKTSAKDLAPTSKVLAK--PTPKAETTTKGPALTTPKEPTPTTPKEPAS 226

Query: 730 TVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQ------RHPAPAVQQ---PFINK 780
           T P+  +  P  + S P   ++    +  S    P +      + PAP   +   P   K
Sbjct: 227 TTPK--EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK 284

Query: 781 ASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIK 840
              +   +++AP    +  P TP KP +P  P++         +P    +  P  +E   
Sbjct: 285 EP-APTTTKSAPTTPKEPAPTTPKKP-APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 342

Query: 841 QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVN 900
            T    AP      A +   +          E +    +EPSP +   P  A  TT    
Sbjct: 343 TTPKEPAPTAPKKPAPTTPKE---PAPTTPKEPAPTTTKEPSPTTPKEP--APTTTKSAP 397

Query: 901 TVVSRP-PPQVQMAPPVSLEP 920
           T    P P   + AP    EP
Sbjct: 398 TTTKEPAPTTTKSAPTTPKEP 418



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 58/273 (21%), Positives = 94/273 (34%), Gaps = 37/273 (13%)

Query: 700 TSPQAGMQTQPQ--IATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSA 757
           T+P+A     P+    T  + P        APT P+  +T P    + P+          
Sbjct: 533 TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK--ETAP----TTPKGTAPTTLKEP 586

Query: 758 SSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPS-----SPPPP 812
           +  T     + PAP    P   K   S    + AP       P TP +P+      P P 
Sbjct: 587 APTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 642

Query: 813 QQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGE 872
                  +    P   T   P  +E    T  T+ P    S+  +              E
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPK---------E 691

Query: 873 ISLPIKEEPSPISKMRPV-TASITTMPVNTVVSRP-----PPQVQMAPPVSLEPMGS--L 924
            +    +EP+P +  +P  T   T  P  + VS P     P  +  +P  S   + +   
Sbjct: 692 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPT 751

Query: 925 SASLENQ-LEAFLDGTLPSANEIPPLQSSSEDR 956
             +LEN   E  +  T   A   P + ++++D+
Sbjct: 752 PKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 784


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 138/698 (19%), Positives = 207/698 (29%), Gaps = 134/698 (19%)

Query: 174 GKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFA 233
           GKE     +   S ++ S+  L+P      +    A + ++     +P   T  TP + A
Sbjct: 207 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 266

Query: 234 SVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS----AKPGPALVKQSHPKNPNDKHR 289
           S +P  P    TP T    P  P  P  PT T S+     +P P   K+  P  P     
Sbjct: 267 STTPKEP----TPTTIKSAPTTPKEPA-PTTTKSAPTTPKEPAPTTTKEPAPTTP----- 316

Query: 290 SKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHY 349
               K+P P   K        P     K+ P      A    ++                
Sbjct: 317 ----KEPAPTTTK-------EPAPTTTKSAPTTPKEPAPTTPKK---------------- 349

Query: 350 NYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELK 409
                 PAP  P                 P TP++ T T  ++P P           E  
Sbjct: 350 ------PAPTTP-------------KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 390

Query: 410 TELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTT 469
                +  P +  +P      +P                 S +      P  T + P TT
Sbjct: 391 PTAPKKPAPTTPKEPAPTTPKEPAPTTTKE---------PSPTTPKEPAPTTTKSAPTTT 441

Query: 470 LH--NTVTSSVSTLKAELPPTGTSN--ATRVENVHSPLPISPSP-SEQSSLSTDDTNMAD 524
                T T S  T   E  PT T     T  +      P  P+P + +    T     A 
Sbjct: 442 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 501

Query: 525 TFTEIMTMMSPSQFLSSSPLRMT-NNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEE 583
           T T+     +P +   ++P          L+PT  T   L     EK           EE
Sbjct: 502 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EE 554

Query: 584 LKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEAS 643
           L     +E       +      K      P E  P+ P                      
Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------------------- 594

Query: 644 LPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQ 703
            P  ++ ++P P        P  T   T        +K+  P              T+P+
Sbjct: 595 -PAPTTPKEPAPTT------PKETAPTTPKGTAPTTLKEPAP--------------TTPK 633

Query: 704 --AGMQTQPQIATAAQIPTAALASGLAPTVPQ-TQDTFPQHVLSQPQQVRKVFTNSASSN 760
             A  +  P   T  + PT+      APT P+ T  T P+       +     T   ++ 
Sbjct: 634 KPAPKELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 690

Query: 761 TVL-----PYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQF 815
           T L        + PAP    P   K   S    + AP    +  P TP +P+   P +  
Sbjct: 691 TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 750

Query: 816 VVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEIS 853
                      ++   P   +E     +S     PE+S
Sbjct: 751 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 788



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 132/707 (18%), Positives = 222/707 (31%), Gaps = 106/707 (14%)

Query: 161  PVDSSVKEAIIGVGKEDYPHTQGDFS--FDEDSSDALSPDQPASQESQGSAASPSEPKVS 218
            P  ++ KE      KE  P T  + S    ++ +   +   P + +      + S P   
Sbjct: 397  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 456

Query: 219  ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
            + PSP TT  PA      PT P   K P       P P  P  P  T +  +P P   K+
Sbjct: 457  KEPSPTTTKEPA------PTTP---KEPAPTTPKKPAPTTPKEPAPT-TPKEPAPTTTKK 506

Query: 279  SHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQ 338
              P  P         K+P P   K    +  P   K  K  P      A    ++     
Sbjct: 507  PAPTTP---------KEPAPTTPK----ETAPTTPK--KLTPTTPEKLAPTTPEKPAPTT 551

Query: 339  LQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPS 398
             + L+              P +P          +    A PNTP++   T  ++P P   
Sbjct: 552  PEELAP-----------TTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP 600

Query: 399  SLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSN 458
                 K     T  +       GT P  ++   P      +            ++     
Sbjct: 601  -----KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 655

Query: 459  PEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTD 518
            P  T   P  T   T      T   E  PT T   T    +  P P +P       L+  
Sbjct: 656  PAPTT--PKGTAPTTPKEPAPTTPKEPAPT-TPKGTAPTTLKEPAPTTPKKPAPKELAPT 712

Query: 519  DTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKE 578
             T              P+   S  P   T  E     T+ T          K     +  
Sbjct: 713  TTK------------GPTSTTSDKPAPTTPKE-----TAPTTPKEPAPTTPK-----KPA 750

Query: 579  KQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRP-LEAQPSAPGHSVKSDQKHGSLGSS 637
                E       E       K    + K   +  P L A+P+    ++++  K   + ++
Sbjct: 751  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTP--KALENSPKEPGVPTT 808

Query: 638  IKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQ 697
                A+ P+ +++ +           P +T     + K+              +++  S+
Sbjct: 809  KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETAT---------TTEKTTESK 859

Query: 698  FYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTF-PQHVLSQPQQVRKVFTNS 756
               +      T  Q  T  +I T    + LAP V  T+ T     ++++P++  K    +
Sbjct: 860  ITATTTQVTSTTTQDTTPFKITTLKTTT-LAPKVTTTKKTITTTEIMNKPEETAKPKDRA 918

Query: 757  ASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFV 816
             +S    P  + P  A ++P   K   ++ + R               KP + P P++  
Sbjct: 919  TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR---------------KPKTTPTPRKMT 963

Query: 817  VQHSLFGSPVAKTKDPPRYEEAIKQ--TRSTQAPLPEISNAHSQQMD 861
                   S + +     R  EA+ Q  TR  Q P  ++   + +  D
Sbjct: 964  -------STMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSED 1003



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 15/144 (10%)

Query: 161 PVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPK--VS 218
           P  ++ KE      KE  P T          S   +P +PA   ++ +  +P EP    +
Sbjct: 257 PTPTTPKEPASTTPKEPTPTTI--------KSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 308

Query: 219 ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
           + P+P T   PA   +  P  P   K+ PT  +  P P  P  P  T +  +P P   K+
Sbjct: 309 KEPAPTTPKEPAPTTTKEP-APTTTKSAPTTPK-EPAPTTPKKPAPT-TPKEPAPTTPKE 365

Query: 279 SHPKNPNDKHRSKKCKDPKPRVKK 302
             P  P  K  +   K+P P   K
Sbjct: 366 PTPTTP--KEPAPTTKEPAPTTPK 387



 Score = 38.1 bits (87), Expect = 0.044
 Identities = 70/321 (21%), Positives = 118/321 (36%), Gaps = 36/321 (11%)

Query: 612 RPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQ- 670
           +P+  +PS P +S  S  K  SL  ++  E ++    ++            +  ST G+ 
Sbjct: 163 KPINPRPSLPPNSDTS--KETSL--TVNKETTVETKETT---------TTNKQTSTDGKE 209

Query: 671 -TLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAP 729
            T  AK+   I++      A    V+++   +P+A   T+    T  + PT       A 
Sbjct: 210 KTTSAKETQSIEKTSAKDLAPTSKVLAK--PTPKAETTTKGPALTTPKEPTPTTPKEPAS 267

Query: 730 TVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQ------RHPAPAVQQ---PFINK 780
           T P+  +  P  + S P   ++    +  S    P +      + PAP   +   P   K
Sbjct: 268 TTPK--EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK 325

Query: 781 ASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIK 840
              +   +++AP    +  P TP KP +P  P++         +P    +  P  +E   
Sbjct: 326 EP-APTTTKSAPTTPKEPAPTTPKKP-APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 383

Query: 841 QTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVN 900
            T    AP      A +   +          E +    +EPSP +   P  A  TT    
Sbjct: 384 TTPKEPAPTAPKKPAPTTPKE---PAPTTPKEPAPTTTKEPSPTTPKEP--APTTTKSAP 438

Query: 901 TVVSRP-PPQVQMAPPVSLEP 920
           T    P P   + AP    EP
Sbjct: 439 TTTKEPAPTTTKSAPTTPKEP 459



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 58/273 (21%), Positives = 94/273 (34%), Gaps = 37/273 (13%)

Query: 700 TSPQAGMQTQPQ--IATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSA 757
           T+P+A     P+    T  + P        APT P+  +T P    + P+          
Sbjct: 574 TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK--ETAP----TTPKGTAPTTLKEP 627

Query: 758 SSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPS-----SPPPP 812
           +  T     + PAP    P   K   S    + AP       P TP +P+      P P 
Sbjct: 628 APTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 683

Query: 813 QQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGE 872
                  +    P   T   P  +E    T  T+ P    S+  +              E
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPK---------E 732

Query: 873 ISLPIKEEPSPISKMRPV-TASITTMPVNTVVSRP-----PPQVQMAPPVSLEPMGS--L 924
            +    +EP+P +  +P  T   T  P  + VS P     P  +  +P  S   + +   
Sbjct: 733 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPT 792

Query: 925 SASLENQ-LEAFLDGTLPSANEIPPLQSSSEDR 956
             +LEN   E  +  T   A   P + ++++D+
Sbjct: 793 PKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 825


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 138/698 (19%), Positives = 207/698 (29%), Gaps = 134/698 (19%)

Query: 174 GKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFA 233
           GKE     +   S ++ S+  L+P      +    A + ++     +P   T  TP + A
Sbjct: 259 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 318

Query: 234 SVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS----AKPGPALVKQSHPKNPNDKHR 289
           S +P  P    TP T    P  P  P  PT T S+     +P P   K+  P  P     
Sbjct: 319 STTPKEP----TPTTIKSAPTTPKEPA-PTTTKSAPTTPKEPAPTTTKEPAPTTP----- 368

Query: 290 SKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHY 349
               K+P P   K        P     K+ P      A    ++                
Sbjct: 369 ----KEPAPTTTK-------EPAPTTTKSAPTTPKEPAPTTPKK---------------- 401

Query: 350 NYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELK 409
                 PAP  P                 P TP++ T T  ++P P           E  
Sbjct: 402 ------PAPTTP-------------KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 442

Query: 410 TELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTT 469
                +  P +  +P      +P                 S +      P  T + P TT
Sbjct: 443 PTAPKKPAPTTPKEPAPTTPKEPAPTTTKE---------PSPTTPKEPAPTTTKSAPTTT 493

Query: 470 LH--NTVTSSVSTLKAELPPTGTSN--ATRVENVHSPLPISPSP-SEQSSLSTDDTNMAD 524
                T T S  T   E  PT T     T  +      P  P+P + +    T     A 
Sbjct: 494 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553

Query: 525 TFTEIMTMMSPSQFLSSSPLRMT-NNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEE 583
           T T+     +P +   ++P          L+PT  T   L     EK           EE
Sbjct: 554 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EE 606

Query: 584 LKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEAS 643
           L     +E       +      K      P E  P+ P                      
Sbjct: 607 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------------------- 646

Query: 644 LPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQ 703
            P  ++ ++P P        P  T   T        +K+  P              T+P+
Sbjct: 647 -PAPTTPKEPAPTT------PKETAPTTPKGTAPTTLKEPAP--------------TTPK 685

Query: 704 --AGMQTQPQIATAAQIPTAALASGLAPTVPQ-TQDTFPQHVLSQPQQVRKVFTNSASSN 760
             A  +  P   T  + PT+      APT P+ T  T P+       +     T   ++ 
Sbjct: 686 KPAPKELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 742

Query: 761 TVL-----PYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQF 815
           T L        + PAP    P   K   S    + AP    +  P TP +P+   P +  
Sbjct: 743 TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 802

Query: 816 VVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEIS 853
                      ++   P   +E     +S     PE+S
Sbjct: 803 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 840



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 132/707 (18%), Positives = 222/707 (31%), Gaps = 106/707 (14%)

Query: 161  PVDSSVKEAIIGVGKEDYPHTQGDFS--FDEDSSDALSPDQPASQESQGSAASPSEPKVS 218
            P  ++ KE      KE  P T  + S    ++ +   +   P + +      + S P   
Sbjct: 449  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 508

Query: 219  ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
            + PSP TT  PA      PT P   K P       P P  P  P  T +  +P P   K+
Sbjct: 509  KEPSPTTTKEPA------PTTP---KEPAPTTPKKPAPTTPKEPAPT-TPKEPAPTTTKK 558

Query: 279  SHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQ 338
              P  P         K+P P   K    +  P   K  K  P      A    ++     
Sbjct: 559  PAPTTP---------KEPAPTTPK----ETAPTTPK--KLTPTTPEKLAPTTPEKPAPTT 603

Query: 339  LQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPS 398
             + L+              P +P          +    A PNTP++   T  ++P P   
Sbjct: 604  PEELAP-----------TTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP 652

Query: 399  SLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSN 458
                 K     T  +       GT P  ++   P      +            ++     
Sbjct: 653  -----KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 707

Query: 459  PEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTD 518
            P  T   P  T   T      T   E  PT T   T    +  P P +P       L+  
Sbjct: 708  PAPTT--PKGTAPTTPKEPAPTTPKEPAPT-TPKGTAPTTLKEPAPTTPKKPAPKELAPT 764

Query: 519  DTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKE 578
             T              P+   S  P   T  E     T+ T          K     +  
Sbjct: 765  TTK------------GPTSTTSDKPAPTTPKE-----TAPTTPKEPAPTTPK-----KPA 802

Query: 579  KQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRP-LEAQPSAPGHSVKSDQKHGSLGSS 637
                E       E       K    + K   +  P L A+P+    ++++  K   + ++
Sbjct: 803  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTP--KALENSPKEPGVPTT 860

Query: 638  IKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQ 697
                A+ P+ +++ +           P +T     + K+              +++  S+
Sbjct: 861  KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETAT---------TTEKTTESK 911

Query: 698  FYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTF-PQHVLSQPQQVRKVFTNS 756
               +      T  Q  T  +I T    + LAP V  T+ T     ++++P++  K    +
Sbjct: 912  ITATTTQVTSTTTQDTTPFKITTLKTTT-LAPKVTTTKKTITTTEIMNKPEETAKPKDRA 970

Query: 757  ASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFV 816
             +S    P  + P  A ++P   K   ++ + R               KP + P P++  
Sbjct: 971  TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR---------------KPKTTPTPRKMT 1015

Query: 817  VQHSLFGSPVAKTKDPPRYEEAIKQ--TRSTQAPLPEISNAHSQQMD 861
                   S + +     R  EA+ Q  TR  Q P  ++   + +  D
Sbjct: 1016 -------STMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSED 1055



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 100/474 (21%), Positives = 170/474 (35%), Gaps = 51/474 (10%)

Query: 470 LHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEI 529
           +HN  TS  S+ KA  PP+G S   +     SP P +   +++   S + T         
Sbjct: 66  VHNP-TSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQ 123

Query: 530 MTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLE 589
            +  S S   SSS +R       +  + ++ +N EL      +KL+ K+ +    K+K  
Sbjct: 124 ESSSSSSSSSSSSTIR------KIKSSKNSAANREL-----QKKLKVKDNKKNRTKKKPT 172

Query: 590 QEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSS 649
            +  +V+     L+        +      S   H+  S     +    I    SLP  S 
Sbjct: 173 PKPPVVDEAGSGLD----NGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 228

Query: 650 SRQPIPVA-----------SHAVGQPVSTGG--QTLVAKKAVVIKQEVPVGQAEQQSVVS 696
           + +   +            +    +  ST G  +T  AK+   I++      A    V++
Sbjct: 229 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 288

Query: 697 QFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNS 756
           +   +P+A   T+    T  + PT       A T P  ++  P  + S P   ++    +
Sbjct: 289 K--PTPKAETTTKGPALTTPKEPTPTTPKEPASTTP--KEPTPTTIKSAPTTPKEPAPTT 344

Query: 757 ASSNTVLPYQ------RHPAPAVQQ---PFINKASNSVLQSRNAPLPSLQNGPNTPNKPS 807
             S    P +      + PAP   +   P   K   +   +++AP    +  P TP KP 
Sbjct: 345 TKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK-EPAPTTTKSAPTTPKEPAPTTPKKP- 402

Query: 808 SPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDIL 867
           +P  P++         +P    +  P  +E    T    AP      A +   +      
Sbjct: 403 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE---PAP 459

Query: 868 IKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRP-PPQVQMAPPVSLEP 920
               E +    +EPSP +   P  A  TT    T    P P   + AP    EP
Sbjct: 460 TTPKEPAPTTTKEPSPTTPKEP--APTTTKSAPTTTKEPAPTTTKSAPTTPKEP 511



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 15/144 (10%)

Query: 161 PVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPK--VS 218
           P  ++ KE      KE  P T          S   +P +PA   ++ +  +P EP    +
Sbjct: 309 PTPTTPKEPASTTPKEPTPTTI--------KSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 360

Query: 219 ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
           + P+P T   PA   +  P  P   K+ PT  +  P P  P  P  T +  +P P   K+
Sbjct: 361 KEPAPTTPKEPAPTTTKEP-APTTTKSAPTTPK-EPAPTTPKKPAPT-TPKEPAPTTPKE 417

Query: 279 SHPKNPNDKHRSKKCKDPKPRVKK 302
             P  P  K  +   K+P P   K
Sbjct: 418 PTPTTP--KEPAPTTKEPAPTTPK 439



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 140/728 (19%), Positives = 232/728 (31%), Gaps = 114/728 (15%)

Query: 236 SPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKD 295
           +PT P     P +   PPP  A+  + + T  S KP            PN K ++KK  +
Sbjct: 68  NPTSP-----PSSKKAPPPSGASQTIKSTTKRSPKP------------PN-KKKTKKVIE 109

Query: 296 PKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQ-------QQQLFLQLQILSQQKQH 348
            +   ++   H      +    +     S+  R ++        ++L  +L++   +K  
Sbjct: 110 SEEITEE---HSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKK-- 164

Query: 349 YNYQTILPAPFKPLNDK-NSNSGNSALNNATPNT-----------PRQNTSTPVRKPGPL 396
            N     P P  P+ D+  S   N      TP+T           P+  T+ P+     L
Sbjct: 165 -NRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSL 223

Query: 397 PSSLDDLKVS------ELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVS 450
           P + D  K +      E   E K        T  D  E+    +E  S    +   +A +
Sbjct: 224 PPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPT 283

Query: 451 SSAIVTSNP--EVTVALPVTTLHNTVTSS-----VSTLKAELPPTGTSNATRVENVHSPL 503
           S  +    P  E T   P  T     T +      ST   E  PT   +A          
Sbjct: 284 SKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTT------- 336

Query: 504 PISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNL 563
           P  P+P+   S  T     A T T+      P+      P   T  E + + T S  +  
Sbjct: 337 PKEPAPTTTKSAPTTPKEPAPTTTK-----EPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 391

Query: 564 ELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGH 623
           +  A    +K         +       ++      K      K      P E  P+AP  
Sbjct: 392 KEPAPTTPKK---PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKK 448

Query: 624 SVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQE 683
              +  K  +           P  +++++P P          +    T   + A    + 
Sbjct: 449 PAPTTPKEPA-----PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 503

Query: 684 VPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVL 743
            P    E          SP    +  P   T  + P        APT P+      +   
Sbjct: 504 APTTPKE---------PSPTTTKEPAP---TTPKEPAPTTPKKPAPTTPK------EPAP 545

Query: 744 SQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQ---PFINKASNSVLQSRNAPLPSLQNGP 800
           + P++     T   +  T     + PAP   +   P   K        + AP    +  P
Sbjct: 546 TTPKEPAPTTTKKPAPTT----PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP 601

Query: 801 NTPNK--PSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQ 858
            TP +  P++P  P     +     +P A   + P+  E    T    AP      A + 
Sbjct: 602 TTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAPTTPKEPAPTTPKEPAPTT 659

Query: 859 QMDDLFDILIKSGEISLPIKEEPSPISKMRP----VTASITTMPVNTVVSRPPPQVQ--M 912
             +        +   +L   +EP+P +  +P    +  + T  P +T   +P P      
Sbjct: 660 PKETAPTTPKGTAPTTL---KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716

Query: 913 APPVSLEP 920
           AP    EP
Sbjct: 717 APTTPKEP 724



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 169/915 (18%), Positives = 284/915 (31%), Gaps = 154/915 (16%)

Query: 78  PAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEE------TFAEPSLQATQMK 131
           P+   + IKS  +   +   K K +   +  E+   H + E      + +  S  +T  K
Sbjct: 81  PSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRK 140

Query: 132 LKRARLAD---DLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFD 188
           +K ++ +    +L +K+  +       +K   P    V EA  G+   D+  T  D S  
Sbjct: 141 IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTT 200

Query: 189 EDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPT 248
           + +  + SP        + + A P  P+ S  P+  T+   +   +   TV E  +T  T
Sbjct: 201 QHNKVSTSP--------KITTAKPINPRPSLPPNSDTSKETSLTVNKETTV-ETKETTTT 251

Query: 249 ADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDK--HRSKKCKDPKPRVKKLKYH 306
             Q           T+T    K   A   QS  K         SK    P P+ +     
Sbjct: 252 NKQ-----------TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKG 300

Query: 307 QYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKN 366
             +   ++     P+  +                  S   +     TI  AP  P     
Sbjct: 301 PALTTPKEPTPTTPKEPA------------------STTPKEPTPTTIKSAPTTPKEPAP 342

Query: 367 SNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDL 426
           + +       + P TP++   T  ++P P          ++       +  P +  +P  
Sbjct: 343 TTT------KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 396

Query: 427 IERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSV------ST 480
               KP     ++            +      P  T   P  T       +       +T
Sbjct: 397 TTPKKP---APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 453

Query: 481 LKAELPPTGTSNATRVENVHSPL-PISPSPSEQSSLSTDDTNMADTFTEIM--TMMSPSQ 537
            K   P T    A       SP  P  P+P+   S  T     A T T+    T   PS 
Sbjct: 454 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513

Query: 538 FLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEV 597
             +  P   T  E +  PT+           +K      KE      K            
Sbjct: 514 TTTKEPAPTTPKEPA--PTTP----------KKPAPTTPKEPAPTTPKEPAPT------- 554

Query: 598 LKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVA 657
                   K+     P E  P+ P  +  +  K  +  +  K   + P+  +   P  +A
Sbjct: 555 ------TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 608

Query: 658 SHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQ--IATA 715
                +P  T  +           +  P              T+P+A     P+    T 
Sbjct: 609 PTTPEEPTPTTPE-----------EPAP--------------TTPKAAAPNTPKEPAPTT 643

Query: 716 AQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQ 775
            + P        APT P+  +T P    + P+          +  T     + PAP    
Sbjct: 644 PKEPAPTTPKEPAPTTPK--ETAP----TTPKGTAPTTLKEPAPTT----PKKPAPKELA 693

Query: 776 PFINKASNSVLQSRNAPLPSLQNGPNTPNKPS-----SPPPPQQFVVQHSLFGSPVAKTK 830
           P   K   S    + AP       P TP +P+      P P        +    P   T 
Sbjct: 694 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP 753

Query: 831 DPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPV 890
             P  +E    T  T+ P    S+  +              E +    +EP+P +  +P 
Sbjct: 754 KKPAPKELAPTT--TKGPTSTTSDKPAPTTPK---------ETAPTTPKEPAPTTPKKPA 802

Query: 891 -TASITTMPVNTVVSRP-----PPQVQMAPPVSLEPMGS--LSASLENQ-LEAFLDGTLP 941
            T   T  P  + VS P     P  +  +P  S   + +     +LEN   E  +  T  
Sbjct: 803 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKT 862

Query: 942 SANEIPPLQSSSEDR 956
            A   P + ++++D+
Sbjct: 863 PAATKPEMTTTAKDK 877


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 138/698 (19%), Positives = 207/698 (29%), Gaps = 134/698 (19%)

Query: 174 GKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFA 233
           GKE     +   S ++ S+  L+P      +    A + ++     +P   T  TP + A
Sbjct: 300 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 359

Query: 234 SVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS----AKPGPALVKQSHPKNPNDKHR 289
           S +P  P    TP T    P  P  P  PT T S+     +P P   K+  P  P     
Sbjct: 360 STTPKEP----TPTTIKSAPTTPKEPA-PTTTKSAPTTPKEPAPTTTKEPAPTTP----- 409

Query: 290 SKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHY 349
               K+P P   K        P     K+ P      A    ++                
Sbjct: 410 ----KEPAPTTTK-------EPAPTTTKSAPTTPKEPAPTTPKK---------------- 442

Query: 350 NYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELK 409
                 PAP  P                 P TP++ T T  ++P P           E  
Sbjct: 443 ------PAPTTP-------------KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 483

Query: 410 TELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTT 469
                +  P +  +P      +P                 S +      P  T + P TT
Sbjct: 484 PTAPKKPAPTTPKEPAPTTPKEPAPTTTKE---------PSPTTPKEPAPTTTKSAPTTT 534

Query: 470 LH--NTVTSSVSTLKAELPPTGTSN--ATRVENVHSPLPISPSP-SEQSSLSTDDTNMAD 524
                T T S  T   E  PT T     T  +      P  P+P + +    T     A 
Sbjct: 535 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594

Query: 525 TFTEIMTMMSPSQFLSSSPLRMT-NNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEE 583
           T T+     +P +   ++P          L+PT  T   L     EK           EE
Sbjct: 595 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EE 647

Query: 584 LKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEAS 643
           L     +E       +      K      P E  P+ P                      
Sbjct: 648 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------------------- 687

Query: 644 LPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQ 703
            P  ++ ++P P        P  T   T        +K+  P              T+P+
Sbjct: 688 -PAPTTPKEPAPTT------PKETAPTTPKGTAPTTLKEPAP--------------TTPK 726

Query: 704 --AGMQTQPQIATAAQIPTAALASGLAPTVPQ-TQDTFPQHVLSQPQQVRKVFTNSASSN 760
             A  +  P   T  + PT+      APT P+ T  T P+       +     T   ++ 
Sbjct: 727 KPAPKELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 783

Query: 761 TVL-----PYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQF 815
           T L        + PAP    P   K   S    + AP    +  P TP +P+   P +  
Sbjct: 784 TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 843

Query: 816 VVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEIS 853
                      ++   P   +E     +S     PE+S
Sbjct: 844 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 881



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 132/707 (18%), Positives = 222/707 (31%), Gaps = 106/707 (14%)

Query: 161  PVDSSVKEAIIGVGKEDYPHTQGDFS--FDEDSSDALSPDQPASQESQGSAASPSEPKVS 218
            P  ++ KE      KE  P T  + S    ++ +   +   P + +      + S P   
Sbjct: 490  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 549

Query: 219  ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
            + PSP TT  PA      PT P   K P       P P  P  P  T +  +P P   K+
Sbjct: 550  KEPSPTTTKEPA------PTTP---KEPAPTTPKKPAPTTPKEPAPT-TPKEPAPTTTKK 599

Query: 279  SHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQ 338
              P  P         K+P P   K    +  P   K  K  P      A    ++     
Sbjct: 600  PAPTTP---------KEPAPTTPK----ETAPTTPK--KLTPTTPEKLAPTTPEKPAPTT 644

Query: 339  LQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPS 398
             + L+              P +P          +    A PNTP++   T  ++P P   
Sbjct: 645  PEELAP-----------TTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP 693

Query: 399  SLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSN 458
                 K     T  +       GT P  ++   P      +            ++     
Sbjct: 694  -----KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 748

Query: 459  PEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTD 518
            P  T   P  T   T      T   E  PT T   T    +  P P +P       L+  
Sbjct: 749  PAPTT--PKGTAPTTPKEPAPTTPKEPAPT-TPKGTAPTTLKEPAPTTPKKPAPKELAPT 805

Query: 519  DTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKE 578
             T              P+   S  P   T  E     T+ T          K     +  
Sbjct: 806  TTK------------GPTSTTSDKPAPTTPKE-----TAPTTPKEPAPTTPK-----KPA 843

Query: 579  KQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRP-LEAQPSAPGHSVKSDQKHGSLGSS 637
                E       E       K    + K   +  P L A+P+    ++++  K   + ++
Sbjct: 844  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTP--KALENSPKEPGVPTT 901

Query: 638  IKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQ 697
                A+ P+ +++ +           P +T     + K+              +++  S+
Sbjct: 902  KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETAT---------TTEKTTESK 952

Query: 698  FYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTF-PQHVLSQPQQVRKVFTNS 756
               +      T  Q  T  +I T    + LAP V  T+ T     ++++P++  K    +
Sbjct: 953  ITATTTQVTSTTTQDTTPFKITTLKTTT-LAPKVTTTKKTITTTEIMNKPEETAKPKDRA 1011

Query: 757  ASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFV 816
             +S    P  + P  A ++P   K   ++ + R               KP + P P++  
Sbjct: 1012 TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR---------------KPKTTPTPRKMT 1056

Query: 817  VQHSLFGSPVAKTKDPPRYEEAIKQ--TRSTQAPLPEISNAHSQQMD 861
                   S + +     R  EA+ Q  TR  Q P  ++   + +  D
Sbjct: 1057 -------STMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSED 1096



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 100/474 (21%), Positives = 170/474 (35%), Gaps = 51/474 (10%)

Query: 470 LHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEI 529
           +HN  TS  S+ KA  PP+G S   +     SP P +   +++   S + T         
Sbjct: 107 VHNP-TSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQ 164

Query: 530 MTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLE 589
            +  S S   SSS +R       +  + ++ +N EL      +KL+ K+ +    K+K  
Sbjct: 165 ESSSSSSSSSSSSTIR------KIKSSKNSAANREL-----QKKLKVKDNKKNRTKKKPT 213

Query: 590 QEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSS 649
            +  +V+     L+        +      S   H+  S     +    I    SLP  S 
Sbjct: 214 PKPPVVDEAGSGLD----NGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 269

Query: 650 SRQPIPVA-----------SHAVGQPVSTGG--QTLVAKKAVVIKQEVPVGQAEQQSVVS 696
           + +   +            +    +  ST G  +T  AK+   I++      A    V++
Sbjct: 270 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 329

Query: 697 QFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNS 756
           +   +P+A   T+    T  + PT       A T P  ++  P  + S P   ++    +
Sbjct: 330 K--PTPKAETTTKGPALTTPKEPTPTTPKEPASTTP--KEPTPTTIKSAPTTPKEPAPTT 385

Query: 757 ASSNTVLPYQ------RHPAPAVQQ---PFINKASNSVLQSRNAPLPSLQNGPNTPNKPS 807
             S    P +      + PAP   +   P   K   +   +++AP    +  P TP KP 
Sbjct: 386 TKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK-EPAPTTTKSAPTTPKEPAPTTPKKP- 443

Query: 808 SPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDIL 867
           +P  P++         +P    +  P  +E    T    AP      A +   +      
Sbjct: 444 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE---PAP 500

Query: 868 IKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRP-PPQVQMAPPVSLEP 920
               E +    +EPSP +   P  A  TT    T    P P   + AP    EP
Sbjct: 501 TTPKEPAPTTTKEPSPTTPKEP--APTTTKSAPTTTKEPAPTTTKSAPTTPKEP 552



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 15/144 (10%)

Query: 161 PVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPK--VS 218
           P  ++ KE      KE  P T          S   +P +PA   ++ +  +P EP    +
Sbjct: 350 PTPTTPKEPASTTPKEPTPTTI--------KSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 401

Query: 219 ESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQ 278
           + P+P T   PA   +  P  P   K+ PT  +  P P  P  P  T +  +P P   K+
Sbjct: 402 KEPAPTTPKEPAPTTTKEP-APTTTKSAPTTPK-EPAPTTPKKPAPT-TPKEPAPTTPKE 458

Query: 279 SHPKNPNDKHRSKKCKDPKPRVKK 302
             P  P  K  +   K+P P   K
Sbjct: 459 PTPTTP--KEPAPTTKEPAPTTPK 480



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 140/728 (19%), Positives = 232/728 (31%), Gaps = 114/728 (15%)

Query: 236 SPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKD 295
           +PT P     P +   PPP  A+  + + T  S KP            PN K ++KK  +
Sbjct: 109 NPTSP-----PSSKKAPPPSGASQTIKSTTKRSPKP------------PN-KKKTKKVIE 150

Query: 296 PKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQ-------QQQLFLQLQILSQQKQH 348
            +   ++   H      +    +     S+  R ++        ++L  +L++   +K  
Sbjct: 151 SEEITEE---HSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKK-- 205

Query: 349 YNYQTILPAPFKPLNDK-NSNSGNSALNNATPNT-----------PRQNTSTPVRKPGPL 396
            N     P P  P+ D+  S   N      TP+T           P+  T+ P+     L
Sbjct: 206 -NRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSL 264

Query: 397 PSSLDDLKVS------ELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVS 450
           P + D  K +      E   E K        T  D  E+    +E  S    +   +A +
Sbjct: 265 PPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPT 324

Query: 451 SSAIVTSNP--EVTVALPVTTLHNTVTSS-----VSTLKAELPPTGTSNATRVENVHSPL 503
           S  +    P  E T   P  T     T +      ST   E  PT   +A          
Sbjct: 325 SKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTT------- 377

Query: 504 PISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNL 563
           P  P+P+   S  T     A T T+      P+      P   T  E + + T S  +  
Sbjct: 378 PKEPAPTTTKSAPTTPKEPAPTTTK-----EPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 432

Query: 564 ELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGH 623
           +  A    +K         +       ++      K      K      P E  P+AP  
Sbjct: 433 KEPAPTTPKK---PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKK 489

Query: 624 SVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQE 683
              +  K  +           P  +++++P P          +    T   + A    + 
Sbjct: 490 PAPTTPKEPA-----PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 544

Query: 684 VPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVL 743
            P    E          SP    +  P   T  + P        APT P+      +   
Sbjct: 545 APTTPKE---------PSPTTTKEPAP---TTPKEPAPTTPKKPAPTTPK------EPAP 586

Query: 744 SQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQ---PFINKASNSVLQSRNAPLPSLQNGP 800
           + P++     T   +  T     + PAP   +   P   K        + AP    +  P
Sbjct: 587 TTPKEPAPTTTKKPAPTT----PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP 642

Query: 801 NTPNK--PSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQ 858
            TP +  P++P  P     +     +P A   + P+  E    T    AP      A + 
Sbjct: 643 TTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAPTTPKEPAPTTPKEPAPTT 700

Query: 859 QMDDLFDILIKSGEISLPIKEEPSPISKMRP----VTASITTMPVNTVVSRPPPQVQ--M 912
             +        +   +L   +EP+P +  +P    +  + T  P +T   +P P      
Sbjct: 701 PKETAPTTPKGTAPTTL---KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757

Query: 913 APPVSLEP 920
           AP    EP
Sbjct: 758 APTTPKEP 765



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 169/915 (18%), Positives = 284/915 (31%), Gaps = 154/915 (16%)

Query: 78  PAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEE------TFAEPSLQATQMK 131
           P+   + IKS  +   +   K K +   +  E+   H + E      + +  S  +T  K
Sbjct: 122 PSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRK 181

Query: 132 LKRARLAD---DLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFD 188
           +K ++ +    +L +K+  +       +K   P    V EA  G+   D+  T  D S  
Sbjct: 182 IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTT 241

Query: 189 EDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPT 248
           + +  + SP        + + A P  P+ S  P+  T+   +   +   TV E  +T  T
Sbjct: 242 QHNKVSTSP--------KITTAKPINPRPSLPPNSDTSKETSLTVNKETTV-ETKETTTT 292

Query: 249 ADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDK--HRSKKCKDPKPRVKKLKYH 306
             Q           T+T    K   A   QS  K         SK    P P+ +     
Sbjct: 293 NKQ-----------TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKG 341

Query: 307 QYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKN 366
             +   ++     P+  +                  S   +     TI  AP  P     
Sbjct: 342 PALTTPKEPTPTTPKEPA------------------STTPKEPTPTTIKSAPTTPKEPAP 383

Query: 367 SNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDL 426
           + +       + P TP++   T  ++P P          ++       +  P +  +P  
Sbjct: 384 TTT------KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 437

Query: 427 IERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSV------ST 480
               KP     ++            +      P  T   P  T       +       +T
Sbjct: 438 TTPKKP---APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 494

Query: 481 LKAELPPTGTSNATRVENVHSPL-PISPSPSEQSSLSTDDTNMADTFTEIM--TMMSPSQ 537
            K   P T    A       SP  P  P+P+   S  T     A T T+    T   PS 
Sbjct: 495 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554

Query: 538 FLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEV 597
             +  P   T  E +  PT+           +K      KE      K            
Sbjct: 555 TTTKEPAPTTPKEPA--PTTP----------KKPAPTTPKEPAPTTPKEPAPT------- 595

Query: 598 LKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVA 657
                   K+     P E  P+ P  +  +  K  +  +  K   + P+  +   P  +A
Sbjct: 596 ------TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 649

Query: 658 SHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQ--IATA 715
                +P  T  +           +  P              T+P+A     P+    T 
Sbjct: 650 PTTPEEPTPTTPE-----------EPAP--------------TTPKAAAPNTPKEPAPTT 684

Query: 716 AQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQ 775
            + P        APT P+  +T P    + P+          +  T     + PAP    
Sbjct: 685 PKEPAPTTPKEPAPTTPK--ETAP----TTPKGTAPTTLKEPAPTT----PKKPAPKELA 734

Query: 776 PFINKASNSVLQSRNAPLPSLQNGPNTPNKPS-----SPPPPQQFVVQHSLFGSPVAKTK 830
           P   K   S    + AP       P TP +P+      P P        +    P   T 
Sbjct: 735 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP 794

Query: 831 DPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPV 890
             P  +E    T  T+ P    S+  +              E +    +EP+P +  +P 
Sbjct: 795 KKPAPKELAPTT--TKGPTSTTSDKPAPTTPK---------ETAPTTPKEPAPTTPKKPA 843

Query: 891 -TASITTMPVNTVVSRP-----PPQVQMAPPVSLEPMGS--LSASLENQ-LEAFLDGTLP 941
            T   T  P  + VS P     P  +  +P  S   + +     +LEN   E  +  T  
Sbjct: 844 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKT 903

Query: 942 SANEIPPLQSSSEDR 956
            A   P + ++++D+
Sbjct: 904 PAATKPEMTTTAKDK 918


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 76/315 (24%), Positives = 127/315 (40%), Gaps = 38/315 (12%)

Query: 201  ASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAP- 259
            A   + G  ++ S P  ++  +P+    PAQ        P     PPT   PP RP  P 
Sbjct: 1066 APSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPS 1125

Query: 260  --VLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEK 317
                P+     A PGPA    + P  P    R+     P+   +       + P+ + + 
Sbjct: 1126 GRSQPSPQAGLAGPGPAGYSTARPTIP---PRAGVISAPQSHARASAGR--LTPESQSKT 1180

Query: 318  NEPQMDSNY-ARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNN 376
            +E    S +    L+ Q  F     L    Q       L  P  P+      SG      
Sbjct: 1181 SETSKGSTFLPEPLKPQAAFPPQSSLPPPAQR------LQEPLVPVAAPMPQSG------ 1228

Query: 377  ATPNTPRQNTSTPVRKPGPLPSSLDDLKV-SELKTELKLRGLPVSGTKPDLIERLKPYQE 435
                 P+ N  TP   P P P S     + SE  ++ +++   +S  K +   ++ P+++
Sbjct: 1229 -----PQPNLETP---PQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFED 1280

Query: 436  VNSSGLAAG-GIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNAT 494
            ++ + LA     ++V +S + T +P+  + LP  T  N V SSVS +   +PP    + +
Sbjct: 1281 LSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLPSATQSN-VLSSVSCMPT-MPPIPARSQS 1338

Query: 495  RVENVHSPLPISPSP 509
            + EN+ S    SP+P
Sbjct: 1339 Q-ENMRS----SPNP 1348



 Score = 33.9 bits (76), Expect = 0.83
 Identities = 71/315 (22%), Positives = 106/315 (33%), Gaps = 54/315 (17%)

Query: 691  QQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVR 750
            Q S  S   TSP +  +T P      Q PT  ++ G  P++P      P      P    
Sbjct: 1026 QPSSSSGLGTSPSSSPRTSP-----CQSPT--ISEGPVPSLPIRPSRAPSRTPGPP---- 1074

Query: 751  KVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPP 810
                 SA S+   P    PA  + Q    K     L+ +  P P     P  P  P  PP
Sbjct: 1075 -----SAQSS---PIDAQPATPLPQ----KDPAQPLEPKRPPPPRPVAPPTRPAPPQRPP 1122

Query: 811  P--------PQQFVVQHSLFGSPVAKTKDPPRY------EEAIKQTRSTQAPLPEISNAH 856
            P        PQ  +      G   A+   PPR       +   + +     P  +   + 
Sbjct: 1123 PPSGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSE 1182

Query: 857  SQQMDDLFDILIKSGEISLPIKEEPSPISKMR-PVTASITTMPVNTVVSRPPPQVQM--A 913
            + +        +K      P    P P  +++ P+      MP     S P P ++    
Sbjct: 1183 TSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMP----QSGPQPNLETPPQ 1238

Query: 914  PPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHS 973
            PP       SL +   +Q +   +G      E P         +PF   EDL  +LL+ S
Sbjct: 1239 PPPRSRSSHSLPSEASSQPQVKTNGISDGKRESP------LKIDPF---EDLSFNLLAVS 1289

Query: 974  -GMLDHSHSPMETSE 987
               L    SP+ T +
Sbjct: 1290 KAQLSVQTSPVPTPD 1304


>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
          Length = 788

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 112/528 (21%), Positives = 202/528 (38%), Gaps = 95/528 (17%)

Query: 576  EKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQP-----------SAPGHS 624
            + ++QI++ +++L++  +L    + Q + +++ QQQ+ L+AQP             P  +
Sbjct: 226  QNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQA 285

Query: 625  V--KSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAK------- 675
            +  +  Q H +       +   P  + + QP  +   +  QP+ +  Q L  +       
Sbjct: 286  LPQQLQQMHHTQHHQPPPQPQQPPVAQN-QPSQLPPQSQTQPLVSQAQALPGQMLYTQPP 344

Query: 676  ----KAVVIKQEVPV-GQAEQQSVVSQFYTS---------------PQAGMQTQ---PQI 712
                +A ++ Q+ PV  Q +QQ    Q   +                Q GM  +   P  
Sbjct: 345  LKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPT 404

Query: 713  ATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPA 772
               + IP++++  G  P    +Q + P  +LS P   ++V T  +     +P    P+P 
Sbjct: 405  TAVSAIPSSSIPLGRQPMAQVSQSSLP--MLSSPSPGQQVQTPQS-----MPPPPQPSPQ 457

Query: 773  VQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSP-------------PPPQQFVVQH 819
              QP  +   NS + S  AP PS      +P    SP             P P    V  
Sbjct: 458  PGQP--SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNP 515

Query: 820  SLFGSPVAKTK-DPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIK 878
            S   SP   ++ +  +Y + +KQ      PL  + N   +  D   D  +   +  L I 
Sbjct: 516  SSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKD--LSKMKSLLDIL 573

Query: 879  EEPS---PISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGS--LSASLENQLE 933
             +PS   P+  ++    ++  +  +  V  PPP     PP   + +    L A L N   
Sbjct: 574  TDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPP--PPVPPTKQQYLCQPLLDAVLANIRS 631

Query: 934  AFLDGTL-----PSANEI--PPL--------QSSSEDREPFSLIEDLQNDLLSHSGMLDH 978
               + +L     P+   I  PP+        +   ED E  S+   LQ ++         
Sbjct: 632  PVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLV 691

Query: 979  SHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSSGLTPL 1026
            +  P   S      GT  L   L D +L ++  L++++P      +PL
Sbjct: 692  NLDPSHCSNN----GTVHLICKLDDKDLPSVPPLELSVPADYPAQSPL 735



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 92/444 (20%), Positives = 163/444 (36%), Gaps = 45/444 (10%)

Query: 556 TSSTLSNLELDAAEKDRKLQEKEKQ-IEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPL 614
           T   L  + L   ++ ++ Q++++  +++ +++ +Q+Q   +   MQ + +   QQQ+ L
Sbjct: 151 TQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQL 210

Query: 615 EAQPSAPGHSVKSD--------------QKHGSLGSSIKDEASLPDCSSSRQPI----PV 656
           + Q     H +K                Q+   L    + +         +Q +    P+
Sbjct: 211 QQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPI 270

Query: 657 ASHAVGQPVSTGGQTLVAKKAVV--IKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIAT 714
               + QP     Q L  +   +   +   P  Q +Q  V     +      QTQP ++ 
Sbjct: 271 QQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQ 330

Query: 715 AAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQ 774
           A  +P   L      T P  +      V+ QP    +V     +  T    Q   AP VQ
Sbjct: 331 AQALPGQMLY-----TQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQM-VAPGVQ 384

Query: 775 QPFINKASNSV-LQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPP 833
                 A   + +++R  P  ++   P+     SS P  +Q + Q S    P+  +  P 
Sbjct: 385 MITEALAQGGMHIRARFPPTTAVSAIPS-----SSIPLGRQPMAQVSQSSLPMLSSPSPG 439

Query: 834 RYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTAS 893
           +  +  +       P P+     SQ   ++      S    LP    PSP     PVTA 
Sbjct: 440 QQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP---SPSPQPSQSPVTA- 495

Query: 894 ITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSS 953
               P N  V  P P   +  PV+   + S + S + + + +LD     +  I PL+   
Sbjct: 496 --RTPQNFSVPSPGP---LNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMI 550

Query: 954 EDREPFSLIEDLQNDLLSHSGMLD 977
                    ED + DL     +LD
Sbjct: 551 ---NKIDKNEDRKKDLSKMKSLLD 571



 Score = 37.4 bits (85), Expect = 0.075
 Identities = 80/366 (21%), Positives = 128/366 (34%), Gaps = 75/366 (20%)

Query: 317 KNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNN 376
           +N+ Q+     +L +  QL LQ Q   QQ+Q    Q  L A   P+            + 
Sbjct: 226 QNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQ-PPIQQPPMQQPQPPPSQ 284

Query: 377 ATPNTPRQNTSTPVRKPGPLP-----------------------SSLDDLKVSELKTE-- 411
           A P   +Q   T   +P P P                       S    L    L T+  
Sbjct: 285 ALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPP 344

Query: 412 LKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGI---VAVSSSAIVTSNPEVTVALPVT 468
           LK    P+   +P +  +++  Q    +  AA  +   V + + A+      +    P T
Sbjct: 345 LKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPT 404

Query: 469 TLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQ---------------- 512
           T       +VS + +   P G     +V     P+  SPSP +Q                
Sbjct: 405 T-------AVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQ 457

Query: 513 ----SSLSTDDTNMADTFTEIMTMMSPSQFLSSSPL--RMTNNEDSLSP--------TSS 558
               SS    + +     +    + SPS   S SP+  R   N    SP         SS
Sbjct: 458 PGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 517

Query: 559 TLSNLELDAAEKDR---KLQEKEKQIEELKR------KLEQEQKLVEVLKMQLEVEKRGQ 609
            +S      AE+ +   KL++  K IE L+R      K E  +K +  +K  L++     
Sbjct: 518 VMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPS 577

Query: 610 QQRPLE 615
           ++ PL+
Sbjct: 578 KRCPLK 583



 Score = 34.3 bits (77), Expect = 0.63
 Identities = 31/95 (32%), Positives = 37/95 (38%), Gaps = 17/95 (17%)

Query: 151 PMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQE----SQ 206
           PM  V ++ LP+ SS                Q   S       +  P QP+SQ     S 
Sbjct: 421 PMAQVSQSSLPMLSSPSPG---------QQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSS 471

Query: 207 GSAASPS----EPKVSESPSPVTTNTPAQFASVSP 237
           G A SPS     P    S SPVT  TP  F+  SP
Sbjct: 472 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSP 506


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 138/586 (23%), Positives = 207/586 (35%), Gaps = 86/586 (14%)

Query: 420 SGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVS 479
           S  KP  ++ L+P Q       AA  +  +SSS + T +P  T A PV    N  T   +
Sbjct: 270 SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPA 329

Query: 480 TLKAELPPTGTSNATRVENVHSPLPISP-SPSEQSSLST------DDTNMADTFTEIMTM 532
           TL    PP  T           PLP++P SPS   SL T         + A        M
Sbjct: 330 TLPPS-PPLAT-----------PLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPM 377

Query: 533 MSPSQFLSSSPLRMTNNEDSLS----PTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKL 588
            +P    +  P+++ ++  S S    P+   LS+L+   +     LQ     +    R+ 
Sbjct: 378 QAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQT 437

Query: 589 EQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCS 648
           +        L              PL+A  S P     S     SL  ++   +S     
Sbjct: 438 QAS------LTSPSRPASTPPDSPPLQAPLSLPA----SPPLQTSLSPAVSPLSSPLTIH 487

Query: 649 SSRQPIPVASHAVGQPVST---------------GGQTLVAKKAVVIKQEVPVGQAEQQS 693
             +    +ASH+   P+S+                 QT  A       + +P        
Sbjct: 488 PLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQ 547

Query: 694 VVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTF-------PQHVLSQP 746
             S   T+P   ++T P     A  P  A  S L    P+T  +        P  + S P
Sbjct: 548 TASAPLTTPH--LETPP---CPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP 602

Query: 747 QQ------VRKVFTNSASSNTVL---PYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQ 797
            Q      +  + T    +   L   P Q  P+P    P    A+ S  Q+ NA    L 
Sbjct: 603 LQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSP-QAPNALAVHLL 661

Query: 798 NGPNTPNKPSSPPPPQQFVVQHSLFGSPVAK--TKDPPRYEEAIKQTRSTQAPLPEISNA 855
             P +P  P SPP    F    S   SP A   ++ PP       Q   +    P +S +
Sbjct: 662 QAPFSP--PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 719

Query: 856 HSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMP-VNTVVSRPPPQVQMAP 914
            +        +         P++  PSP +   P++ S T  P V  +++ PP QV  +P
Sbjct: 720 ATPPPQAPPPLAAP------PLQVPPSPPASP-PMSPSATPPPRVPPLLAAPPLQVPPSP 772

Query: 915 PVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFS 960
           P SL PM  L+        A      P    +P   +S   + PFS
Sbjct: 773 PASL-PMSPLAKPPPQAPPAL---ATPPLQALPSPPASFPGQAPFS 814



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 95/398 (23%), Positives = 147/398 (36%), Gaps = 70/398 (17%)

Query: 633 SLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTL-------VAKKAVVIKQEVP 685
           S G+S ++ AS P  S   +  P A +    PVS+ G+         + +K + I  E  
Sbjct: 82  SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141

Query: 686 VGQAEQQSVVSQFYTSPQAGMQTQ------PQIATAAQIPTAALASGLAPTVPQTQDTFP 739
           V + +      +   S  A   T       P  A A +   A    GL    P  +   P
Sbjct: 142 VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 201

Query: 740 QHVLSQPQQVRKVFTNSASSNTVLP---YQRHPAP--AVQQPFINKASNSV--LQSRNAP 792
                  +  RK  ++++  +T  P    +R P+    +Q+P     S+S   L S    
Sbjct: 202 ------TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255

Query: 793 LPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEI 852
            PS +  P  P  PS P P     ++      P   T  PPR + A      + +PL   
Sbjct: 256 GPSARGTPRAPAHPSQPKPKGLQALR------PPQVT--PPRKDAAPALGPLSSSPLATP 307

Query: 853 SNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQM 912
           S                SG  + P+   P P +   P+ A   T+P +  ++ P P    
Sbjct: 308 S---------------PSGTKARPV---PPPDNAATPLPA---TLPPSPPLATPLPLAPP 346

Query: 913 AP--PVSLEPMGSLSASLENQLEAFLD----GTLPSANEIPPLQ------SSSEDREPFS 960
           +P  P SL+ + S  A+  +Q    +        PS   IPP+Q      S S    P  
Sbjct: 347 SPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSP 406

Query: 961 L-IEDLQ--NDLLSHSGMLDHSHSPMETSETQFAAGTP 995
           L +  LQ    L S +    HS   M   +TQ +  +P
Sbjct: 407 LALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSP 444



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 134/634 (21%), Positives = 194/634 (30%), Gaps = 86/634 (13%)

Query: 220 SPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQS 279
           S SP+ T +P+   +     P+   TP  A  PP  P A  LP    S + P       S
Sbjct: 300 SSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPS 359

Query: 280 HPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEK-NEPQMDSNYARL-LQQQQLFL 337
            P  P  +        P      L   Q IPP Q       P + +  + L L   Q   
Sbjct: 360 PPATPPSQAPPSMTTPPMQAPPSL---QTIPPIQVPHSLTSPSLQAPPSPLALSSLQATT 416

Query: 338 QLQILSQQKQH-------YNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPV 390
            L   + Q  H          Q  L +P +P +    +    A  +   + P Q + +P 
Sbjct: 417 SLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPA 476

Query: 391 RKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVS 450
             P   P ++  L+         L  L     +  L   + P  E  SS LA   +    
Sbjct: 477 VSPLSSPLTIHPLQA--------LSSLASHSPQAPLSSLIMPPLETQSS-LAPPSLQTPP 527

Query: 451 SSAI---------VTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHS 501
           +S           +   P  T + P+TT H       +    + PP             S
Sbjct: 528 ASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPP-------------S 574

Query: 502 PLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLS 561
           PL  +P P   SS++T                 P Q L S PL         +P    L 
Sbjct: 575 PL-TTPPPETPSSIATPPPQAPPALAS-----PPLQGLPSPPLSPLATPPPQAPPXLALP 628

Query: 562 NLELDAAEKDRKLQEKEKQIEELKRKLEQEQK--LVEVLKMQLEVEKRGQQQRPLE--AQ 617
            L+   +            +  L     Q      V +L+           Q P    A 
Sbjct: 629 PLQAPPS------PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 682

Query: 618 PSAPGHSVKSDQKHGSLGSSIKDEASLPDCS---------SSRQPIPVASHAVGQPVSTG 668
           P     +    Q   SL +        P  S           + P P+A+  +  P S  
Sbjct: 683 PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPP 742

Query: 669 GQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLA 728
               ++  A    +  P+  A    V      SP A +   P      Q P  ALA+   
Sbjct: 743 ASPPMSPSATPPPRVPPLLAAPPLQVP----PSPPASLPMSPLAKPPPQAP-PALATPPL 797

Query: 729 PTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHP---APAVQQPFINKASNSV 785
             +P    +FP      P       +   S     P Q  P   AP +Q P    AS ++
Sbjct: 798 QALPSPPASFPGQAPFSPSA-----SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTL 852

Query: 786 LQSRNAPLPSLQNGPNTPN-----KPSSPPPPQQ 814
              R  P P      + P       P  PPPP +
Sbjct: 853 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 886



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 26/84 (30%), Positives = 33/84 (39%), Gaps = 12/84 (14%)

Query: 197 PDQPASQESQGSAASPSE-------PKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTA 249
           P  PAS     SA  P +       P +   PSP  +   +  A+  P VP  L  PP  
Sbjct: 708 PSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQ 767

Query: 250 DQPPPRPAAPVLPTNTVSSAKPGP 273
             P P  + P+ P      AKP P
Sbjct: 768 VPPSPPASLPMSPL-----AKPPP 786



 Score = 33.9 bits (76), Expect = 0.83
 Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 6/91 (6%)

Query: 212 PSEPKVSESPSPVTT---NTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS 268
           P+   +   PSP+TT    TP+  A+  P  P  L +PP    P P P +P+        
Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSP-PLSPL--ATPPPQ 620

Query: 269 AKPGPALVKQSHPKNPNDKHRSKKCKDPKPR 299
           A P  AL     P +P           P P+
Sbjct: 621 APPXLALPPLQAPPSPPASPPLSPLATPSPQ 651



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 13/105 (12%)

Query: 200 PASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAP 259
           P S   Q   + P+ P VS S +P     P+Q        P  L  PP    P P  + P
Sbjct: 668 PPSPPVQAPFSPPASPPVSPSATP-----PSQ-------APPSLAAPPLQVPPSPPASPP 715

Query: 260 VLPTNTVSSAKPGP-ALVKQSHPKNPNDKHRSKKCKDPKPRVKKL 303
           + P+ T     P P A      P +P           P PRV  L
Sbjct: 716 MSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPL 760



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 30/107 (28%), Positives = 39/107 (36%), Gaps = 11/107 (10%)

Query: 200 PASQESQGSAASPSE-------PKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQP 252
           PAS     SA  PS+       P +   PSP  +   +  A+  P  P  L  PP    P
Sbjct: 680 PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP-LQVP 738

Query: 253 PPRPAAPVLPTNTVSSAKPGPALVK---QSHPKNPNDKHRSKKCKDP 296
           P  PA+P +  +     +  P L     Q  P  P     S   K P
Sbjct: 739 PSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP 785



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 28/107 (26%), Positives = 40/107 (37%), Gaps = 5/107 (4%)

Query: 196 SPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFA---SVSPTVPEFLKTPPTADQP 252
           +P   A+   Q   + P+ P +S S +P     P   A    V P+ P  L   P A  P
Sbjct: 726 APPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP 785

Query: 253 PPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPR 299
           P  P  P L T  + +    PA      P +P+          P P+
Sbjct: 786 PQAP--PALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 23/82 (28%), Positives = 32/82 (39%), Gaps = 6/82 (7%)

Query: 197 PDQPASQESQGSAASPS--EPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPP 254
           P+ P+S  +    A P+   P +   PSP  +      A+  P  P  L  PP    P P
Sbjct: 581 PETPSSIATPPPQAPPALASPPLQGLPSPPLS----PLATPPPQAPPXLALPPLQAPPSP 636

Query: 255 RPAAPVLPTNTVSSAKPGPALV 276
             + P+ P  T S   P    V
Sbjct: 637 PASPPLSPLATPSPQAPNALAV 658


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 77/310 (24%), Positives = 113/310 (36%), Gaps = 63/310 (20%)

Query: 211 SPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTP---PTADQPPPRPAAPVLPTNTVS 267
           SPS P      SP     P +  +  PT P   +TP   P    P PR  +P  P     
Sbjct: 549 SPSPPPTRRRRSPSPAPPPRRRRT--PTPPPRRRTPSPPPRRRSPSPRRYSP--PIQRRY 604

Query: 268 SAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKG----EKNEPQMD 323
           S  P P     S P  P  K R+     PK RV         PP Q+     ++  P + 
Sbjct: 605 SPSPPPKRRTASPPPPP--KRRASPSPPPKRRVSHSP-----PPKQRSSPVTKRRSPSLS 657

Query: 324 SNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPR 383
           S + +     +   + +     K+H       P+P +P   + S+S         P   R
Sbjct: 658 SKHRKGSSPSRSTREARSPQPNKRHS------PSP-RPRAPQTSSS--------PPPVRR 702

Query: 384 QNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAA 443
             +S+P R+  P PS+    +VS      K++    +   P  + R              
Sbjct: 703 GASSSPQRRQSPSPSTRPIRRVSRTPEPKKIK--KAASPSPQSVRR-------------- 746

Query: 444 GGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPL 503
                VSSS  V+ +PE     P         +  S ++++ P T  S A  V+   SP 
Sbjct: 747 -----VSSSRSVSGSPEPAAKKP--------PAPPSPVQSQSPSTNWSPAVPVKKAKSPT 793

Query: 504 PISPSPSEQS 513
           P SPSP   S
Sbjct: 794 P-SPSPPRNS 802



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 6/101 (5%)

Query: 212 PSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQP-----PPRPAAPVLPTNTV 266
           P + K + SPSP +    +   SVS +     K PP    P     P    +P +P    
Sbjct: 730 PKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKA 789

Query: 267 SSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQ 307
            S  P P+  + S  +    K + KK K  K + KK K H+
Sbjct: 790 KSPTPSPSPPRNSDQEGGGKKKKKKKDKKHK-KDKKHKKHK 829



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 29/122 (23%), Positives = 48/122 (39%), Gaps = 18/122 (14%)

Query: 200 PASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAP 259
           P+    + +A+ P  PK   SPSP     P +  S SP        P     P  +  +P
Sbjct: 606 PSPPPKRRTASPPPPPKRRASPSP----PPKRRVSHSP-------PPKQRSSPVTKRRSP 654

Query: 260 VLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNE 319
            L +     + P  +  +++    PN +H       P PR +  +     PP ++G  + 
Sbjct: 655 SLSSKHRKGSSPSRS-TREARSPQPNKRH------SPSPRPRAPQTSSSPPPVRRGASSS 707

Query: 320 PQ 321
           PQ
Sbjct: 708 PQ 709



 Score = 34.7 bits (78), Expect = 0.48
 Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 19/174 (10%)

Query: 764 PYQRHPAPAVQQPFINKA-SNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHS-- 820
           P +R P+P    P I +  S S    R    P     P  P + +SP PP +  V HS  
Sbjct: 586 PRRRSPSPRRYSPPIQRRYSPSPPPKRRTASP-----PPPPKRRASPSPPPKRRVSHSPP 640

Query: 821 --LFGSPVAKTKDP---PRYEEAIKQTRST-QAPLPEISNAHSQQMDDLFDILIKSGEIS 874
                SPV K + P    ++ +    +RST +A  P+ +  HS           ++    
Sbjct: 641 PKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAP---QTSSSP 697

Query: 875 LPIKEEPSPISKMRPVTASITTMPVNTVVSRP-PPQVQMAPPVSLEPMGSLSAS 927
            P++   S  S  R  + S +T P+  V   P P +++ A   S + +  +S+S
Sbjct: 698 PPVRRGASS-SPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSS 750



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 44/221 (19%), Positives = 76/221 (34%), Gaps = 22/221 (9%)

Query: 191 SSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTAD 250
           SS +LS    +S  S+  +     PK + SP   T        S SP       +PP   
Sbjct: 351 SSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSP---SASPPRRRHRPSPPATP 407

Query: 251 QPPPRPAAPVLPTNTV--SSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQY 308
            P  R +     +N    S     P        K+   + R      PKPR  +L   + 
Sbjct: 408 PPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEE 467

Query: 309 IPPDQKGEKNEPQMDSNYARLLQQ----------------QQLFLQLQILSQQKQHYNYQ 352
               +    +  Q    Y R  QQ                ++  ++   + ++++H   +
Sbjct: 468 DKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSR 527

Query: 353 TILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKP 393
           +  P+P K    + S  G    + + P T R+ + +P   P
Sbjct: 528 SASPSPRK-RQKETSPRGRRRRSPSPPPTRRRRSPSPAPPP 567



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 26/99 (26%), Positives = 37/99 (37%), Gaps = 11/99 (11%)

Query: 201 ASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPV 260
           +S  S   +  P+  K    PSPV + +P+   + SP VP      PT    PPR +   
Sbjct: 748 SSSRSVSGSPEPAAKKPPAPPSPVQSQSPS--TNWSPAVPVKKAKSPTPSPSPPRNS--- 802

Query: 261 LPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPR 299
                      G    K+   K+  DK   K  K  K +
Sbjct: 803 ------DQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEK 835


>gi|148612879 polyhomeotic like 3 [Homo sapiens]
          Length = 995

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 111/501 (22%), Positives = 191/501 (38%), Gaps = 69/501 (13%)

Query: 474 VTSSVSTLKAELPPTGT-SNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTE-IMT 531
           V +S+S+ +    PTG+ +  + +      L  SP+P++  S S   ++ + + T+  M 
Sbjct: 111 VQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTML 170

Query: 532 MMSPSQFLSSSPLRMTNNEDSLSPTSSTL-----SNLELDAAEKDRKLQEKEKQIEELKR 586
           + S S  L++S  +M      L  T +T      S++ + ++      Q    Q++ L  
Sbjct: 171 LGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTL 230

Query: 587 KLEQEQKLVEVLKMQLEVEKRGQQQRPLE-AQPSAPGHSVKSDQKHGSLGSSIKDEASLP 645
           +    QKL  +   Q    K   Q + L          S K  Q+  S  S+ K E+   
Sbjct: 231 R---SQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSL 287

Query: 646 DCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAG 705
           +   SR      + ++ Q ++    + +   +++  Q++P+     +       +  Q  
Sbjct: 288 E---SRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSK------VSHHQLI 338

Query: 706 MQTQPQIATAAQIPTAALASGLAPTVPQTQDTFP-QHVLSQPQQVRKVFTNSASSNTVLP 764
           +Q Q Q     QI    L +        TQD  P QH +           ++A S    P
Sbjct: 339 LQQQQQ-----QIQPITLQNS-------TQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSP 386

Query: 765 YQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPP----PQQFVVQHS 820
            Q HP+P    P          QS++A   S+   P  P+ PS  P     PQ  +  H 
Sbjct: 387 IQSHPSPLTVSP---------NQSQSAQ-QSVVVSPPPPHSPSQSPTIIIHPQALIQPHP 436

Query: 821 LFGSPVAKTKDPPRYEEAIKQTRST-------QAPLPEISNAHSQQMDDLFDILIKSG-E 872
           L  S  A    P   +    Q ++T         PLP     H   +      L+  G +
Sbjct: 437 LVSS--ALQPGPNLQQSTANQVQATAQLNLPSHLPLPASPVVHIGPVQQ--SALVSPGQQ 492

Query: 873 ISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLE--N 930
           I  P  ++ S +       AS   M  +     PP Q+   PP+ L+ M SL    E  +
Sbjct: 493 IVSPSHQQYSSLQSSPIPIASPPQMSTS-----PPAQI---PPLPLQSMQSLQVQPEILS 544

Query: 931 QLEAFLDGTLPSANEIPPLQS 951
           Q +  +   L S  E+P  ++
Sbjct: 545 QGQVLVQNALVSEEELPAAEA 565



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 129/678 (19%), Positives = 238/678 (35%), Gaps = 109/678 (16%)

Query: 186 SFDEDSSDALSPDQPASQESQGSAASPSEPKVSE------SPSPVTTNTPAQF------- 232
           S  + S +  +   PA   S+  A+S +   +++      S SP  T + AQ        
Sbjct: 133 SMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML 192

Query: 233 ----ASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKH 288
               A+    V   +    ++     + AA  +   T+ S K G     Q+ P     + 
Sbjct: 193 IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQT 252

Query: 289 RSKKCKDPKPRVKKLKYHQYIPPDQKGEKNE-PQMDSNYARLLQQQQLFLQLQILSQQKQ 347
           +S      K  V   K  Q  P  +  +K E P ++S    + +   +            
Sbjct: 253 QSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSI------------ 300

Query: 348 HYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSE 407
              +Q I PA + P+                P++  ++   P+  P P   S   L + +
Sbjct: 301 ---HQLIAPASYSPIQ---------------PHSLIKHQQIPLHSP-PSKVSHHQLILQQ 341

Query: 408 LKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPV 467
            + +++   L  S   P   +   P Q   + GL      A S++     +P  +   P+
Sbjct: 342 QQQQIQPITLQNSTQDPPPSQHCIPLQ---NHGLPP----APSNAQSQHCSPIQSHPSPL 394

Query: 468 TTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFT 527
           T   N   S+  ++    PP  + + +    +H    I P P   S+L         T  
Sbjct: 395 TVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTAN 454

Query: 528 EIMT---MMSPSQF-LSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEE 583
           ++     +  PS   L +SP+                  + +   ++   +   ++ +  
Sbjct: 455 QVQATAQLNLPSHLPLPASPV------------------VHIGPVQQSALVSPGQQIVS- 495

Query: 584 LKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQ-PSAPGHSVKSDQKHGSLGSSIKDEA 642
                   Q+   +    + +    Q      AQ P  P  S++S Q    + S  + + 
Sbjct: 496 -----PSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILS--QGQV 548

Query: 643 SLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSP 702
            + +   S + +P A   V  P     QTL   + V +  +V         VV Q     
Sbjct: 549 LVQNALVSEEELPAAEALVQLPF----QTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVC 604

Query: 703 QAGM-QTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSAS--- 758
           +  M +   +     + P     S  A TV + +D   +H L +  ++  V + SAS   
Sbjct: 605 EEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIK 664

Query: 759 SNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQ----- 813
           S +   +   P P +  P     SNS   S ++ +PS++N P     P +   PQ     
Sbjct: 665 SPSDPSHVSVPPPPLLLPAATTRSNST--SMHSSIPSIENKP-----PQAIVKPQILTHV 717

Query: 814 --QFVVQHSLFGSPVAKT 829
              FV+Q  L   PV+++
Sbjct: 718 IEGFVIQEGLEPFPVSRS 735


>gi|31324577 molecule interacting with Rab13 [Homo sapiens]
          Length = 863

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 77/326 (23%), Positives = 116/326 (35%), Gaps = 40/326 (12%)

Query: 682 QEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIP--------------TAALASGL 727
           ++VP G     +        P+A  + +PQI T  ++P              T A     
Sbjct: 250 KDVPGGGPSSSAPAGAEADGPKASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKAS 309

Query: 728 APTVPQTQDTFPQHVLSQPQQVRKVFTNSASSN------------TVLPYQRHPAPAVQQ 775
             T P      P+  L Q   V +  ++S  +             T  P +  PAP    
Sbjct: 310 ESTTPAPPTPRPRSSLQQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSEGTPAPRKDP 369

Query: 776 PFINKASNSVLQSRNAPLP-SLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPR 834
           P+I        + + APLP S   GP + +         + V Q S   S  +K  +P  
Sbjct: 370 PWITLVQAEP-KKKPAPLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTASLESKPYNPFE 428

Query: 835 YEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASI 894
            EE  K+  +  AP    S A         +   KS      I    SP +K RP   + 
Sbjct: 429 EEEEDKEEEAPAAPSLATSPALGHP-----ESTPKSLHPWYGITPTSSPKTKKRPAPRAP 483

Query: 895 TTMPVNTVVSR----PPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQ 950
           +  P+    SR     PP    +P +S+E + S SAS     E      +P ++  P + 
Sbjct: 484 SASPLALHASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPAVPKSSSEPAVH 543

Query: 951 SSSEDREPFSLIEDLQNDLLSHSGML 976
           +      P SL     N  L+ SG L
Sbjct: 544 APGTPGNPVSL---STNSSLASSGEL 566



 Score = 31.6 bits (70), Expect = 4.1
 Identities = 47/190 (24%), Positives = 63/190 (33%), Gaps = 22/190 (11%)

Query: 208 SAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPA--APVLPTNT 265
           S  S SEP  S +PSP  +       S S T    L  PP   +    PA  AP  P N 
Sbjct: 493 SRLSHSEPP-SATPSPALSVESLSSESASQTAGAELLEPPAVPKSSSEPAVHAPGTPGNP 551

Query: 266 VSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSN 325
           V S     +L        P  +   +      PR +     Q   P          +  +
Sbjct: 552 V-SLSTNSSLASSGELVEPRVEQMPQASPGLAPRTRGSSGPQPAKPCSGATPTPLLLVGD 610

Query: 326 YARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQN 385
            + +        QLQ+ S  K++            P N K S + + A   AT       
Sbjct: 611 RSPVPSPGSSSPQLQVKSSCKEN------------PFNRKPSPAASPATKKATKG----- 653

Query: 386 TSTPVRKPGP 395
            S PVR P P
Sbjct: 654 -SKPVRPPAP 662


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 81/343 (23%), Positives = 135/343 (39%), Gaps = 52/343 (15%)

Query: 201  ASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPV 260
            A   + G  ++ S P  ++  +P+    PAQ        P     PPT   PP RP  P 
Sbjct: 1110 APSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPS 1169

Query: 261  LPTNTVSSAK----------PGPALVKQSHPKNPNDKHRSKKCK-DPKPRV-----KKLK 304
               +   + K          PG A  +   PK+P    +    +  P P+          
Sbjct: 1170 GARSPAPTRKEFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAG 1229

Query: 305  YHQYIP--PDQKGEKNEPQMD--SNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK 360
            Y    P  P + G  + PQ    ++  RL  + Q        S+  +     T LP P K
Sbjct: 1230 YSTARPTIPPRAGVISAPQSHARASAGRLTPESQ--------SKTSETSKGSTFLPEPLK 1281

Query: 361  P---------LNDKNSNSGNSALNNATP---NTPRQNTSTPVRKPGPLPSSLDDLKV-SE 407
            P         L           +  A P   + P+ N  TP   P P P S     + SE
Sbjct: 1282 PQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETP---PQPPPRSRSSHSLPSE 1338

Query: 408  LKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAG-GIVAVSSSAIVTSNPEVTVALP 466
              ++ +++   +S  K +   ++ P+++++ + LA     ++V +S + T +P+  + LP
Sbjct: 1339 ASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLP 1398

Query: 467  VTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSP 509
              T  N V SSVS +   +PP    + ++ EN+ S    SP+P
Sbjct: 1399 SATQSN-VLSSVSCMPT-MPPIPARSQSQ-ENMRS----SPNP 1434



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 34/122 (27%), Positives = 44/122 (36%), Gaps = 23/122 (18%)

Query: 691  QQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVR 750
            Q S  S   TSP +  +T P      Q PT  ++ G  P++P      P      P    
Sbjct: 1070 QPSSSSGLGTSPSSSPRTSP-----CQSPT--ISEGPVPSLPIRPSRAPSRTPGPP---- 1118

Query: 751  KVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPP 810
                 SA S+   P    PA  + Q    K     L+ +  P P     P  P  P  PP
Sbjct: 1119 -----SAQSS---PIDAQPATPLPQ----KDPAQPLEPKRPPPPRPVAPPTRPAPPQRPP 1166

Query: 811  PP 812
            PP
Sbjct: 1167 PP 1168



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 77/345 (22%), Positives = 123/345 (35%), Gaps = 72/345 (20%)

Query: 645  PDCSSSRQPIPVASH--AVGQPVSTGGQTLVAKKAVVIKQEVPVGQAE-QQSVVSQFYTS 701
            P  S +R P P       +G P S G    VA++    + E P      ++  + +   S
Sbjct: 1166 PPPSGARSPAPTRKEFGGIGAPPSPG----VARR----EMEAPKSPGTTRKDNIGRSQPS 1217

Query: 702  PQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNT 761
            PQAG+        +   PT    +G+  + PQ+        L+   Q +   T+  S+  
Sbjct: 1218 PQAGLAGPGPAGYSTARPTIPPRAGVI-SAPQSHARASAGRLTPESQSKTSETSKGSTFL 1276

Query: 762  VLPYQRH-----------PAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPP 810
              P +             PA  +Q+P +  A         AP+P     PN    P  PP
Sbjct: 1277 PEPLKPQAAFPPQSSLPPPAQRLQEPLVPVA---------APMPQSGPQPNLETPPQPPP 1327

Query: 811  PPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDL-FDIL-I 868
              +     HSL   P   +  P      I   +  ++PL           +DL F++L +
Sbjct: 1328 RSRS---SHSL---PSEASSQPQVKTNGISDGK-RESPL------KIDPFEDLSFNLLAV 1374

Query: 869  KSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASL 928
               ++S+     P+P  K      S T   V + VS  P         ++ P+ + S S 
Sbjct: 1375 SKAQLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMP---------TMPPIPARSQSQ 1425

Query: 929  EN-------------QLEAFLDGTLPSANEIPPLQSSSEDREPFS 960
            EN             +   F D T    N   P ++ SE+ E  S
Sbjct: 1426 ENMRSSPNPFITGLTRTNPFSDRTAAPGN---PFRAKSEESEATS 1467



 Score = 30.8 bits (68), Expect = 7.0
 Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 19/96 (19%)

Query: 733  QTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQ-----RHPAPAV---------QQPFI 778
            + ++  PQH+  QP     + T+ +SS    P Q       P P++         + P  
Sbjct: 1060 EVEELLPQHL--QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGP 1117

Query: 779  NKASNSVLQSRNA-PLPSLQNGPNTPNKPSSPPPPQ 813
              A +S + ++ A PLP  Q  P  P +P  PPPP+
Sbjct: 1118 PSAQSSPIDAQPATPLP--QKDPAQPLEPKRPPPPR 1151


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 48/157 (30%), Positives = 65/157 (41%), Gaps = 24/157 (15%)

Query: 189 EDSSDALSPDQPASQESQGSAASPSEPKVSE---SPSPVTTNTPAQFA---SVS-PTVPE 241
           + +S A  P Q   ++S+  A  P  P  +    SPSP     P Q     SVS P  P+
Sbjct: 517 QPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPK 576

Query: 242 FLKTPPTADQ---PPPRPAAPVLPTNTVSSAKP----GPALVKQSHPKNPNDKHRSKKCK 294
               PP   Q   PP +P  P  PT   S A P    GP   +Q  P  P    R     
Sbjct: 577 ASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGR----- 631

Query: 295 DPKPRVKKLKYHQYIPPD---QKGEKNEPQMDSNYAR 328
            PKP++ + K  Q +PP      G    PQ+ ++ A+
Sbjct: 632 -PKPQLAQ-KPSQDVPPPATAAAGGPPHPQLKASPAQ 666


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 72/294 (24%), Positives = 104/294 (35%), Gaps = 48/294 (16%)

Query: 1   MDHTGAIDTEDEVGPL---------AHLAPSPQSEAVAHEFQELSLQSSQNLPPLN---- 47
           M H   +    E GP          A +   P  E +  E Q   LQ  Q    L     
Sbjct: 104 MMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL--EIQRRQLQEQQRQKELERERL 161

Query: 48  -----ERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIR 102
                ER+ + + RL++ R   + ++Q  +   +      E+++  ER   +  L+ + R
Sbjct: 162 ERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQER 221

Query: 103 SRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPV 162
              +R E      LE    E   +  Q +L+R +L  +   +I+    P           
Sbjct: 222 LDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAP----------- 270

Query: 163 DSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQES-QGSAASPSEPKVSESP 221
            +SV+  +  V         GD S  E    A S  QPA   S QG    P  P     P
Sbjct: 271 -ASVETPLNSV--------LGDSSASEPGLQAAS--QPAETPSQQGIVLGPLAP----PP 315

Query: 222 SPVTTNTPAQFASVSPTVPEFLKTPP-TADQPPPRPAAPVLPTNTVSSAKPGPA 274
            P     PAQ +   P  P     PP  +  PPP P  P LP        P PA
Sbjct: 316 PPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPA 369


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 72/294 (24%), Positives = 104/294 (35%), Gaps = 48/294 (16%)

Query: 1   MDHTGAIDTEDEVGPL---------AHLAPSPQSEAVAHEFQELSLQSSQNLPPLN---- 47
           M H   +    E GP          A +   P  E +  E Q   LQ  Q    L     
Sbjct: 104 MMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL--EIQRRQLQEQQRQKELERERL 161

Query: 48  -----ERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIR 102
                ER+ + + RL++ R   + ++Q  +   +      E+++  ER   +  L+ + R
Sbjct: 162 ERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQER 221

Query: 103 SRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPV 162
              +R E      LE    E   +  Q +L+R +L  +   +I+    P           
Sbjct: 222 LDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAP----------- 270

Query: 163 DSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQES-QGSAASPSEPKVSESP 221
            +SV+  +  V         GD S  E    A S  QPA   S QG    P  P     P
Sbjct: 271 -ASVETPLNSV--------LGDSSASEPGLQAAS--QPAETPSQQGIVLGPLAP----PP 315

Query: 222 SPVTTNTPAQFASVSPTVPEFLKTPP-TADQPPPRPAAPVLPTNTVSSAKPGPA 274
            P     PAQ +   P  P     PP  +  PPP P  P LP        P PA
Sbjct: 316 PPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPA 369


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 44/137 (32%), Positives = 57/137 (41%), Gaps = 21/137 (15%)

Query: 189 EDSSDALSPDQPASQESQGSAASPSEPKVSE---SPSPVTTNTPAQFA---SVS-PTVPE 241
           + +S A  P Q   ++S+  A  P  P  +    SPSP     P Q     SVS P  P+
Sbjct: 517 QPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPK 576

Query: 242 FLKTPPTADQ---PPPRPAAPVLPTNTVSSAKP----GPALVKQSHPKNPNDKHRSKKCK 294
               PP   Q   PP +P  P  PT   S A P    GP   +Q  P  P    R     
Sbjct: 577 ASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGR----- 631

Query: 295 DPKPRVKKLKYHQYIPP 311
            PKP++ + K  Q +PP
Sbjct: 632 -PKPQLAQ-KPSQDVPP 646


>gi|33667044 ABI gene family, member 3 (NESH) binding protein [Homo
           sapiens]
          Length = 1075

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 77/338 (22%), Positives = 124/338 (36%), Gaps = 44/338 (13%)

Query: 197 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPA----QFASVSPTV---PEFLKTPPTA 249
           P  P ++  + ++A    PK+S+SP P T  TPA    QF S+ P +   PE   T P  
Sbjct: 476 PKPPRTKPERTTSAGTITPKISKSPEP-TWTTPAPGKTQFISLKPKIPLSPEVTHTKPAP 534

Query: 250 DQPPPRPAAP-VLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQY 308
            Q P  P  P   P   +   +P P + ++   K             P P+   L +  Y
Sbjct: 535 KQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPY 594

Query: 309 --------IPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFK 360
                    P + +G    P +  + +    Q++L   L+   Q  Q   + T +P   +
Sbjct: 595 PEVSQSEPAPLETRGIPFIPMISPSPS----QEELQTTLEETDQSTQE-PFTTKIPRTTE 649

Query: 361 PLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLD-----DLKVSELKTELKLR 415
               K + + +       P T  +    P  K  P PS  D     D      K   +  
Sbjct: 650 LA--KTTQAPHRFYTTVRPRTSDKPHIRPGVKQAPRPSGADRNVSVDSTHPTKKPGTRRP 707

Query: 416 GLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVT 475
            LP   T P    R KP    N +G    G   + SS  +T+ P  +   P  T    + 
Sbjct: 708 PLPPRPTHP----RRKPLPPNNVTG--KPGSAGIISSGPITTPPLRSTPRPTGTPLERIE 761

Query: 476 SSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQS 513
           + +        PT  ++   +EN+      S SP+ ++
Sbjct: 762 TDIK------QPTVPASGEELENI---TDFSSSPTRET 790



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 61/302 (20%), Positives = 107/302 (35%), Gaps = 29/302 (9%)

Query: 624 SVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAK-KAVVIKQ 682
           S KS +K   LG  I     +P  + +   +P +   +   +S   +T +AK + + +  
Sbjct: 265 SAKSPEK-APLGGVILVHLIIPGLNETTVKLPAS---LMFEISDALKTQLAKNETLALPA 320

Query: 683 EVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHV 742
           E    + E+ S      T       T+P  ++A  +    LAS   P +  T        
Sbjct: 321 ESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSK 380

Query: 743 LSQPQQVR-KVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPN 801
           + QPQ     VF++  +S+          P +   +    S+ +L S           P 
Sbjct: 381 VLQPQTATYDVFSSPTTSD---------EPEISDSY-TATSDRILDSIPPKTSRTLEQPR 430

Query: 802 TPNKPSSPPPPQQFVVQH-SLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQM 860
               PS  P    FV Q   +F SP  +   P   +     +   + P P+      ++ 
Sbjct: 431 ATLAPSETP----FVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERT 486

Query: 861 DDLFDILIKSGEISLPIKEEPSP-------ISKMRPVTASIT-TMPVNTVVSRPPPQVQM 912
                I  K  +   P    P+P       +    P++  +T T P      R PP+ + 
Sbjct: 487 TSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPKQTPRAPPKPKT 546

Query: 913 AP 914
           +P
Sbjct: 547 SP 548


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 60/278 (21%), Positives = 108/278 (38%), Gaps = 50/278 (17%)

Query: 569 EKDR-KLQEKEKQIE---------ELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQP 618
           EKDR + QEKEK++E         E +RK E+E++L    + + E++K  +Q++  E + 
Sbjct: 532 EKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEK 591

Query: 619 SAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAV 678
                  K + +  +L   ++ + S   C+   +P                        V
Sbjct: 592 EREKLEEKIEPREPNLEPMVEKQESENSCNKEEEP------------------------V 627

Query: 679 VIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTF 738
             +Q+    + E   VV +  T P++G Q +P + +            L P   + Q+  
Sbjct: 628 FTRQDSNRSEKEATPVVHE--TEPESGSQPRPAVLSGY---FKQFQKSLPPRFQRQQEQM 682

Query: 739 PQHVLSQPQQ---VRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPS 795
            Q    Q QQ   + +   +  SS+TV P    P     QP     ++     R   + S
Sbjct: 683 KQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQS 742

Query: 796 LQNGPNTPNKPSS--PP------PPQQFVVQHSLFGSP 825
             +      +P+   PP      PP+  + +  + GSP
Sbjct: 743 YMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSP 780



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 85/371 (22%), Positives = 132/371 (35%), Gaps = 35/371 (9%)

Query: 561  SNLELDA-AEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPL----- 614
            SNL  D   E   K Q+K  Q EE ++K   E+++++V   +   EK   Q   L     
Sbjct: 1674 SNLNDDGFTEVVSKKQQKRLQDEERRKK---EEQVIQVWNKKNANEKGRSQTSKLPPRFA 1730

Query: 615  --------EAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVS 666
                    +AQ SA    + S     S  +S+    S P   ++  P+P AS +   P S
Sbjct: 1731 KKQATGIQQAQSSASVPPLASAPLPPSTSASVPASTSAP-LPATLTPVP-ASTSAPVPAS 1788

Query: 667  TGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAGMQTQPQIATAAQIPTAALASG 726
            T    L +  A V    +    A   SV +    S  A   T      +A  PT  LAS 
Sbjct: 1789 TLAPVLASTSAPVPASPLAPVSASA-SVSASVPASTSAAAITSSSAPASAPAPTPILASV 1847

Query: 727  LAPTVPQTQDTFPQHVLSQPQQVRKVFTNS-ASSNTVLPYQRHPAPAVQQPFINKASNSV 785
              P       +    +L+         T + A+S+   P    P      P  +      
Sbjct: 1848 STPASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPA 1907

Query: 786  LQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRST 845
              S  AP P+  + PN    P+ P P Q     H    +P+  T    +      +  S 
Sbjct: 1908 SASAPAPAPTPVSAPN----PAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSA 1963

Query: 846  QAPLP----------EISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASIT 895
            Q P            +   +H     +L+D  +    +   I ++  PIS  +P + S  
Sbjct: 1964 QTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPISPPQPPSVSAW 2023

Query: 896  TMPVNTVVSRP 906
              P+ +  S P
Sbjct: 2024 NKPLTSFGSAP 2034



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 97/476 (20%), Positives = 173/476 (36%), Gaps = 78/476 (16%)

Query: 244  KTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKL 303
            K  P  DQP       ++     SSA     +   +  KN  D    KK +DPKP  KK 
Sbjct: 1584 KRGPFDDQPAGTTGVDLI---NGSSAHHQEGVPNGTGQKNSKDS-TGKKREDPKPGPKKP 1639

Query: 304  K-------------YHQYIPPDQKGEKN---EPQM---DSNYARLLQQQQLFLQLQILSQ 344
            K             Y   +  D   E     +PQ    D  +  ++ ++Q   Q ++  +
Sbjct: 1640 KEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQ---QKRLQDE 1696

Query: 345  QKQHYNYQTILPAPFKPLNDKNSNS-GNSALNNATPNTPRQ----------NTSTPVRKP 393
            +++    Q I     +  N KN+N  G S  +   P   ++          + S P    
Sbjct: 1697 ERRKKEEQVI-----QVWNKKNANEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLAS 1751

Query: 394  GPLPSSLDDLKVSELKTELK--LRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSS 451
             PLP S      +     L   L  +P S + P     L P     S+ + A  +  VS+
Sbjct: 1752 APLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVPASPLAPVSA 1811

Query: 452  SAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENV----HSPLPISP 507
            SA       V+ ++P +T    +TSS +   A  P    ++ +   +V     + +PI  
Sbjct: 1812 SA------SVSASVPASTSAAAITSSSAPASAPAPTPILASVSTPASVTILASASIPILA 1865

Query: 508  SPSEQSSLSTDDTNMADTFTEIMTM-----MSPSQFLSSSPLRMTNNEDSLSPTSSTLSN 562
            S    +S  T     +     ++T       +P+  +  +P   +    + +P S+    
Sbjct: 1866 SALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPVSAPNPA 1925

Query: 563  LELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPG 622
                A  + +  +  +  ++   +  +Q    + +             Q P      A G
Sbjct: 1926 PPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRL----------PSAQTPNGTDYVASG 1975

Query: 623  HSVKSDQKHGSLGSSIKDE-----ASLPDCSSSRQPI----PVASHAVGQPVSTGG 669
             S+++ Q HG+L + + D      A L D S    PI    P +  A  +P+++ G
Sbjct: 1976 KSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPISPPQPPSVSAWNKPLTSFG 2031



 Score = 38.1 bits (87), Expect = 0.044
 Identities = 146/654 (22%), Positives = 225/654 (34%), Gaps = 127/654 (19%)

Query: 191  SSDALSPDQPASQESQGSAASPSEPKVSESPSPV--TTNTPAQFASV-SPTVPEFLKTPP 247
            +S ++S   PAS  S  +  S S P  + +P+P+  + +TPA    + S ++P       
Sbjct: 1811 ASASVSASVPAST-SAAAITSSSAPASAPAPTPILASVSTPASVTILASASIPILASALA 1869

Query: 248  TADQPPPRPAA-----PVLPTNTV--------------SSAKPGPALVKQSHPKNPNDKH 288
            +   P P PAA     PV+   T+              S++ P PA    S P       
Sbjct: 1870 STSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPVSAPNPAPPAP 1929

Query: 289  RSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQH 348
               + +  KP    L+        Q  ++  P +    A+           + +   + H
Sbjct: 1930 AQTQAQTHKPVQNPLQ-----TTSQSSKQPPPSIRLPSAQTPNGTDYVASGKSIQTPQSH 1984

Query: 349  YNYQTIL----PAPFKPLNDKNSNSGNSALNNATPNTPRQNTST-----PVRKPGPLPSS 399
                  L     AP   LND +   G        P +P Q  S      P+   G  PSS
Sbjct: 1985 GTLTAELWDNKVAPPAVLNDISKKLG--------PISPPQPPSVSAWNKPLTSFGSAPSS 2036

Query: 400  LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNP 459
                   E   E+        GT  D I+   P    N +      +V V S       P
Sbjct: 2037 EGAKNGQESGLEI--------GT--DTIQFGAPASNGNEN-----EVVPVLSEKSADKIP 2081

Query: 460  EVTV-------ALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISP----S 508
            E          A P+        S V   + +  P G   + +   V     + P     
Sbjct: 2082 EPKEQRQKQPRAGPIKAQKLPDLSPVENKEHKPGPIGKERSLKNRKVKDAQQVEPEGQEK 2141

Query: 509  PSEQSSLSTDDTNMADT------FTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSN 562
            PS  +  STD     +T       TEI TM+S      SS    TN ++S++  ++  S+
Sbjct: 2142 PSPATVRSTDPVTTKETKAVSEMSTEIGTMIS-----VSSAEYGTNAKESVTDYTTPSSS 2196

Query: 563  LELDAAEKDRKLQEKEKQIEEL--------KRKLEQEQKLVEV------LKMQLEVEKRG 608
            L    A  + K+++       L        +  ++Q   L  V      L  ++E  ++ 
Sbjct: 2197 LPNTVATNNTKMEDTLVNNVPLPNTLPLPKRETIQQSSSLTSVPPTTFSLTFKMESARKA 2256

Query: 609  QQQRPLEAQPSAPGHSVKSDQKHG-SLGSSIKDEASLPDCSSSRQP-IPVASHAVGQPVS 666
             +  P   +  +P  S       G S  +S    A+    SS+  P IPVAS      +S
Sbjct: 2257 WENSPNVREKGSPVTSTAPPIATGVSSSASGPSTANYNSFSSASMPQIPVASVTPTASLS 2316

Query: 667  TGG----QTLVAKKAV---------VIKQEVPVGQAEQQSVVSQFYTSPQ--AGMQTQPQ 711
              G     +L  K            V  Q++        S  SQ    P   A  Q  PQ
Sbjct: 2317 GAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQQQQNPQ 2376

Query: 712  I----ATAAQIPTAALASG---------LAPTVPQTQDTFPQHVLSQPQQVRKV 752
            +    + AAQIP   + +          LAP     Q  F Q  LSQP  V+++
Sbjct: 2377 VYVSQSAAAQIPAFYMDTSHLFNTQHARLAPPSLAQQQGF-QPGLSQPTSVQQI 2429



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 2/60 (3%)

Query: 209  AASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSS 268
            + S S P  + +P P T  TP   AS S  VP     P  A    P PA+P+ P +  +S
Sbjct: 1757 STSASVPASTSAPLPATL-TPVP-ASTSAPVPASTLAPVLASTSAPVPASPLAPVSASAS 1814



 Score = 30.4 bits (67), Expect = 9.1
 Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 3/69 (4%)

Query: 206  QGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNT 265
            Q + +S S P ++ +P P +T+     AS S  +P  L TP  A    P PA+ + P   
Sbjct: 1738 QQAQSSASVPPLASAPLPPSTSASVP-ASTSAPLPATL-TPVPASTSAPVPASTLAPV-L 1794

Query: 266  VSSAKPGPA 274
             S++ P PA
Sbjct: 1795 ASTSAPVPA 1803


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 86/376 (22%), Positives = 146/376 (38%), Gaps = 55/376 (14%)

Query: 500 HSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMS--PSQFL-------------SSSPL 544
           HSP P + S S + S  T  ++ + T T+I T  S  P Q L             SS  +
Sbjct: 426 HSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSI 485

Query: 545 RMTNNEDSLS-PTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVE--VLKMQ 601
              +   SL+ P  S  +NL +       +   +   ++ LK +LEQ  +++E  + + Q
Sbjct: 486 NSQSVGSSLTQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQ 545

Query: 602 LEVEKRGQQQRPLEA-------QPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPI 654
            E+ K  +Q + +         Q S PG +  S Q      S+I+  A +     + Q  
Sbjct: 546 EELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPI-----NMQGQ 600

Query: 655 PVASHAVGQPVSTG---------GQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYTSPQAG 705
            V ++ +   ++TG          Q  +   +   +Q V  G ++Q S+ SQ  ++  A 
Sbjct: 601 VVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAP 660

Query: 706 MQ-----TQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQ-VRKVFTNSASS 759
           +      +QP   +  QIP++   +        T     Q   SQ QQ V K+ T   + 
Sbjct: 661 LYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVAC 720

Query: 760 NTVL---------PYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPP 810
             V+             +P  A QQ      S +  Q + +           P++     
Sbjct: 721 GAVMVPSTMLMGQVVTAYPTFATQQQQSQTLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQ 780

Query: 811 PPQQFV-VQHSLFGSP 825
           PPQQF+     L G+P
Sbjct: 781 PPQQFLQTSRLLHGNP 796


>gi|241982780 programmed cell death 6 interacting protein isoform 2
           [Homo sapiens]
          Length = 873

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 29/77 (37%), Positives = 36/77 (46%), Gaps = 4/77 (5%)

Query: 198 DQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPA 257
           D+      Q  A  PS P +   P+P   ++PA   + +P  P     PPT  QPP RP 
Sbjct: 708 DELLKDLQQSIAREPSAPSI---PTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPP 764

Query: 258 APVLPTNTVSSA-KPGP 273
            PVLP N   SA  P P
Sbjct: 765 PPVLPANRAPSATAPSP 781


>gi|22027538 programmed cell death 6 interacting protein isoform 1
           [Homo sapiens]
          Length = 868

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 29/77 (37%), Positives = 36/77 (46%), Gaps = 4/77 (5%)

Query: 198 DQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPA 257
           D+      Q  A  PS P +   P+P   ++PA   + +P  P     PPT  QPP RP 
Sbjct: 703 DELLKDLQQSIAREPSAPSI---PTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPP 759

Query: 258 APVLPTNTVSSA-KPGP 273
            PVLP N   SA  P P
Sbjct: 760 PPVLPANRAPSATAPSP 776


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.124    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,121,222
Number of Sequences: 37866
Number of extensions: 2606839
Number of successful extensions: 25740
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 256
Number of HSP's successfully gapped in prelim test: 1151
Number of HSP's that attempted gapping in prelim test: 16534
Number of HSP's gapped (non-prelim): 8845
length of query: 1049
length of database: 18,247,518
effective HSP length: 113
effective length of query: 936
effective length of database: 13,968,660
effective search space: 13074665760
effective search space used: 13074665760
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.