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Search of human proteins with 125628632
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|125628632 keratin 80 isoform b [Homo sapiens]
(422 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|125628632 keratin 80 isoform b [Homo sapiens] 818 0.0
gi|125628636 keratin 80 isoform a [Homo sapiens] 797 0.0
gi|153791158 keratin 75 [Homo sapiens] 337 1e-92
gi|4504919 keratin 8 [Homo sapiens] 327 1e-89
gi|119395754 keratin 5 [Homo sapiens] 322 3e-88
gi|109255249 keratin 4 [Homo sapiens] 321 9e-88
gi|5031839 keratin 6A [Homo sapiens] 318 8e-87
gi|155969697 keratin 6C [Homo sapiens] 317 1e-86
gi|67782365 keratin 7 [Homo sapiens] 317 1e-86
gi|119703753 keratin 6B [Homo sapiens] 316 2e-86
gi|109148552 keratin 3 [Homo sapiens] 315 6e-86
gi|32567786 keratin 6L [Homo sapiens] 310 2e-84
gi|153791670 keratin 76 [Homo sapiens] 308 5e-84
gi|28173564 keratin 73 [Homo sapiens] 305 4e-83
gi|27477127 keratin 82 [Homo sapiens] 305 5e-83
gi|28372503 keratin 72 isoform 1 [Homo sapiens] 304 1e-82
gi|226246663 keratin 72 isoform 1 [Homo sapiens] 304 1e-82
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 303 2e-82
gi|119395750 keratin 1 [Homo sapiens] 303 3e-82
gi|15618995 keratin 71 [Homo sapiens] 300 2e-81
gi|47132620 keratin 2 [Homo sapiens] 297 1e-80
gi|4504935 keratin 85 [Homo sapiens] 295 4e-80
gi|148612803 keratin 6 irs4 [Homo sapiens] 295 7e-80
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap... 287 1e-77
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap... 287 1e-77
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap... 287 1e-77
gi|14318422 keratin 86 [Homo sapiens] 287 1e-77
gi|169790853 keratin, hair, basic, 1 [Homo sapiens] 285 7e-77
gi|169790841 keratin 83 [Homo sapiens] 282 4e-76
gi|194018511 keratin 77 [Homo sapiens] 281 8e-76
>gi|125628632 keratin 80 isoform b [Homo sapiens]
Length = 422
Score = 818 bits (2112), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTV 60
MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTV
Sbjct: 1 MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTV 60
Query: 61 NPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQG 120
NPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQG
Sbjct: 61 NPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQG 120
Query: 121 QDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTD 180
QDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTD
Sbjct: 121 QDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTD 180
Query: 181 MEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGM 240
MEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGM
Sbjct: 181 MEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGM 240
Query: 241 DSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIA 300
DSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIA
Sbjct: 241 DSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIA 300
Query: 301 DLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMA 360
DLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMA
Sbjct: 301 DLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMA 360
Query: 361 RQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTAPSLPYPLC 420
RQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTAPSLPYPLC
Sbjct: 361 RQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTAPSLPYPLC 420
Query: 421 SL 422
SL
Sbjct: 421 SL 422
>gi|125628636 keratin 80 isoform a [Homo sapiens]
Length = 452
Score = 797 bits (2058), Expect = 0.0
Identities = 413/414 (99%), Positives = 413/414 (99%)
Query: 1 MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTV 60
MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTV
Sbjct: 1 MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTV 60
Query: 61 NPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQG 120
NPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQG
Sbjct: 61 NPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQG 120
Query: 121 QDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTD 180
QDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTD
Sbjct: 121 QDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTD 180
Query: 181 MEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGM 240
MEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGM
Sbjct: 181 MEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGM 240
Query: 241 DSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIA 300
DSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIA
Sbjct: 241 DSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIA 300
Query: 301 DLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMA 360
DLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMA
Sbjct: 301 DLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMA 360
Query: 361 RQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTAPS 414
RQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTA S
Sbjct: 361 RQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTAAS 414
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 337 bits (864), Expect = 1e-92
Identities = 177/377 (46%), Positives = 259/377 (68%), Gaps = 3/377 (0%)
Query: 29 SGWDSCRAPGPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMK 88
SG+ G GFS S C G I +VTVN LL PL +++DP +Q+++ +E+E++K
Sbjct: 96 SGFGYGGGVGGGFSGPSFPVC-PPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIK 154
Query: 89 ALNDKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIF--DLGHLYEEYQGRLQEELRKV 146
LN+KFAS I KV+ LEQ+N++LET+W+ LQ Q S +L L++ Y L+ +L +
Sbjct: 155 TLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESI 214
Query: 147 SQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKL 206
+ ERG+LEA L + + VE+F++RYEDEI+KRT E FV LKKD+DA +++ ELE K+
Sbjct: 215 TTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKV 274
Query: 207 KSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARS 266
KSL + + ++++ EL L QV D SV + MD+ ++DL I+ EVKAQY+ +A RS
Sbjct: 275 KSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDIANRS 334
Query: 267 LEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEEN 326
EAE++ +++ EE + +G L++++ EI+++N IQ+LR++I SVK C L+
Sbjct: 335 RAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTA 394
Query: 327 IKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKL 386
I AE++GELA +DA+ KL LE ALQ+AKQDMAR LR+YQELMN+KLALD+EIATYRKL
Sbjct: 395 IADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKL 454
Query: 387 VEGEEGRMDSPSATVVS 403
+EGEE R+ + V+
Sbjct: 455 LEGEECRLSGEGVSPVN 471
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 327 bits (839), Expect = 1e-89
Identities = 166/349 (47%), Positives = 252/349 (72%)
Query: 48 GCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQR 107
G G I+ VTVN LL PL +++DP +Q ++ QEKE++K LN+KFAS I KV+ LEQ+
Sbjct: 56 GASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQ 115
Query: 108 NQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEF 167
N++LET+WS LQ Q +A ++ +++E Y L+ +L + QE+ +LEA L + VE+F
Sbjct: 116 NKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDF 175
Query: 168 RIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDL 227
+ +YEDEI+KRT+ME FV +KKD+D +++ ELE++L+ L + ++ +YE+E+++L
Sbjct: 176 KNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIREL 235
Query: 228 AAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAE 287
+Q+ D SV + MD+ +D+ I+ EVKAQY+ +A RS EAE+ + + EE + + +
Sbjct: 236 QSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGK 295
Query: 288 YGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQ 347
+G L+ +++EI+++N I +L+++I +K LE I AE++GELA +DA KL++
Sbjct: 296 HGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSE 355
Query: 348 LEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDS 396
LEAALQ+AKQDMARQLR+YQELMNVKLALDIEIATYRKL+EGEE R++S
Sbjct: 356 LEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES 404
Score = 30.4 bits (67), Expect = 3.2
Identities = 34/175 (19%), Positives = 72/175 (41%), Gaps = 14/175 (8%)
Query: 138 RLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECL 197
RLQ E+ + +R LEA + ++ E + +D +K +++E + K+D+ +
Sbjct: 316 RLQAEIEGLKGQRASLEAAIADAEQRGE---LAIKDANAKLSELEAALQRAKQDMARQLR 372
Query: 198 HRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKA 257
EL +L+ + + + E E L + ++++S+ SG + +
Sbjct: 373 EYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTK-------TTSGYAGGLSS 425
Query: 258 QYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQ 312
Y + + L +YS A S+ + + S + + R KL S+
Sbjct: 426 AYGGLTSPGL----SYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSE 476
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 322 bits (826), Expect = 3e-88
Identities = 166/359 (46%), Positives = 250/359 (69%), Gaps = 3/359 (0%)
Query: 38 GPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASL 97
G GF C G I +VTVN LL PL++++DP++Q+++ +E+E++K LN+KFAS
Sbjct: 124 GGGFGGPGFPVC-PPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASF 182
Query: 98 IGKVQALEQRNQLLETRWSFLQGQDSAIF--DLGHLYEEYQGRLQEELRKVSQERGQLEA 155
I KV+ LEQ+N++L+T+W+ LQ Q + +L L+E+Y L+ +L + ERG+L++
Sbjct: 183 IDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDS 242
Query: 156 NLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVEL 215
L + + VE+F+ +YEDEI+KRT E FV LKKD+DA +++ ELE K+ +L +
Sbjct: 243 ELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINF 302
Query: 216 MKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSR 275
MK ++ EL + V D SV + MD+ ++DL I+ EVKAQY+ +A RS EAE++ +
Sbjct: 303 MKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQ 362
Query: 276 SQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGE 335
++ EE + +G L++++ EI+++N IQ+LR++I +VK C L+ I AE++GE
Sbjct: 363 TKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGE 422
Query: 336 LAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM 394
LA +DA+ KLA+LE ALQ+AKQDMAR LR+YQELMN KLALD+EIATYRKL+EGEE R+
Sbjct: 423 LALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRL 481
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 321 bits (822), Expect = 9e-88
Identities = 170/378 (44%), Positives = 259/378 (68%), Gaps = 10/378 (2%)
Query: 38 GPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASL 97
GPGF AG I +VT+N LL PL V++DP +Q+++ +E+E++K LN+KFAS
Sbjct: 172 GPGFP------VCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASF 225
Query: 98 IGKVQALEQRNQLLETRWSFLQGQDSAIF--DLGHLYEEYQGRLQEELRKVSQERGQLEA 155
I KVQ LEQ+N++LET+W+ LQ Q + +L L+E Y L+++L + ++G+L++
Sbjct: 226 IDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQS 285
Query: 156 NLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVEL 215
L + + VE+F+ +YE+EI+KRT E FV LKKD+DA L++ ELE K+ SL +
Sbjct: 286 ELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINF 345
Query: 216 MKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSR 275
+K +Y+ EL + V D SV + MD+ ++DL I+ EV+AQY+ +A RS EAEA +
Sbjct: 346 LKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQ 405
Query: 276 SQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGE 335
+++++ ++G +L++++SEIA+LN IQ+LR++I ++K C L+ ++ AE++GE
Sbjct: 406 TKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE 465
Query: 336 LAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM- 394
A +DA +K +LEAALQQAK+++AR LR+YQELM+VKLALDIEIATYRKL+EGEE RM
Sbjct: 466 NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMS 525
Query: 395 -DSPSATVVSAVQSRCKT 411
+ SA +S V T
Sbjct: 526 GECQSAVSISVVSGSTST 543
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 318 bits (814), Expect = 8e-87
Identities = 168/374 (44%), Positives = 253/374 (67%), Gaps = 10/374 (2%)
Query: 38 GPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASL 97
GPGF G I +VTVN LL PL++++DP +Q+++ +E+E++K LN+KFAS
Sbjct: 124 GPGFP------VCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASF 177
Query: 98 IGKVQALEQRNQLLETRWSFLQGQDSAIF--DLGHLYEEYQGRLQEELRKVSQERGQLEA 155
I KV+ LEQ+N++LET+W+ LQ Q + +L L+E+Y L+ +L + ERG+L++
Sbjct: 178 IDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDS 237
Query: 156 NLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVEL 215
L + + VE+F+ +YEDEI+KRT E FV LKKD+DA +++ EL+ K +L +
Sbjct: 238 ELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 216 MKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSR 275
++ +Y+ EL + + D SV + MD+ ++DL I+ EVKAQY+ +A RS EAE++ +
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQ 357
Query: 276 SQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGE 335
++ EE + +G L++++ EIA++N IQ+LRS+I VK C L+ I AE++GE
Sbjct: 358 TKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGE 417
Query: 336 LAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMD 395
+A +DAK KL LE ALQ+AKQD+AR L++YQELMNVKLALD+EIATYRKL+EGEE R++
Sbjct: 418 MALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLN 477
Query: 396 SPSA--TVVSAVQS 407
+S VQS
Sbjct: 478 GEGVGQVNISVVQS 491
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 317 bits (812), Expect = 1e-86
Identities = 168/374 (44%), Positives = 253/374 (67%), Gaps = 10/374 (2%)
Query: 38 GPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASL 97
GPGF G I +VTVN LL PL++++DPA+Q+++ +E+E++K LN+KFAS
Sbjct: 124 GPGFP------VCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASF 177
Query: 98 IGKVQALEQRNQLLETRWSFLQGQDSAIF--DLGHLYEEYQGRLQEELRKVSQERGQLEA 155
I KV+ LEQ+N++L+T+W+ LQ Q + +L L+E+Y L+ +L + ERG+L++
Sbjct: 178 IDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDS 237
Query: 156 NLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVEL 215
L + + VE+ + +YEDEI+KRT E FV LKKD+DA +++ EL+ K +L +
Sbjct: 238 ELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 216 MKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSR 275
++ +Y+ EL + + D SV + MD+ ++DL I+ EVKAQY+ +A RS EAE++ +
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQ 357
Query: 276 SQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGE 335
++ EE + +G L++++ EIA++N IQ+LRS+I VK C L+ I AE++GE
Sbjct: 358 TKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGE 417
Query: 336 LAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMD 395
+A +DAK KL LE ALQ+AKQD+AR L++YQELMNVKLALD+EIATYRKL+EGEE R++
Sbjct: 418 MALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLN 477
Query: 396 SPSA--TVVSAVQS 407
VS VQS
Sbjct: 478 GEGVGQVNVSVVQS 491
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 317 bits (812), Expect = 1e-86
Identities = 179/393 (45%), Positives = 262/393 (66%), Gaps = 6/393 (1%)
Query: 21 VGSPRPGTSGWDSCRAPG---PGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQ 77
+ S RPG G S G P + RS G I +VT+N LL PL + DP++Q
Sbjct: 26 LSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGAGIREVTINQSLLAPLRLDADPSLQ 85
Query: 78 QLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFD-LGHLYEEYQ 136
+++ +E E++K LN+KFAS I KV+ LEQ+N+LLET+W+ LQ Q SA L ++E
Sbjct: 86 RVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQI 145
Query: 137 GRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAEC 196
L+ +L + + G+LEA L + + VE+F+ +YEDEI+ RT E FV LKKD+DA
Sbjct: 146 AGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAY 205
Query: 197 LHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVK 256
+ + ELE K+ +L + ++T+ E EL +L +Q+ D SV + MD+ +DL GI+ EVK
Sbjct: 206 MSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVK 265
Query: 257 AQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSV 316
AQY+ +A S EAEA+ +++ E A++ ++G L+++R+EI+++N IQ+L+++I ++
Sbjct: 266 AQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNI 325
Query: 317 KSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLAL 376
K+ KLE I AEE+GELA +DA+ K +LEAALQ+ KQDMARQLR+YQELM+VKLAL
Sbjct: 326 KNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLAL 385
Query: 377 DIEIATYRKLVEGEEGRM--DSPSATVVSAVQS 407
DIEIATYRKL+EGEE R+ D A +S + S
Sbjct: 386 DIEIATYRKLLEGEESRLAGDGVGAVNISVMNS 418
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 316 bits (810), Expect = 2e-86
Identities = 167/374 (44%), Positives = 253/374 (67%), Gaps = 10/374 (2%)
Query: 38 GPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASL 97
GPGF G I +VTVN LL PL++++DPA+Q+++ +E+E++K LN+KFAS
Sbjct: 124 GPGFP------VCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASF 177
Query: 98 IGKVQALEQRNQLLETRWSFLQGQDSAIF--DLGHLYEEYQGRLQEELRKVSQERGQLEA 155
I KV+ LEQ+N++L+T+W+ LQ Q + +L L+E+Y L+ +L + ERG+L++
Sbjct: 178 IDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDS 237
Query: 156 NLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVEL 215
L + + VE+ + +YEDEI+KRT E FV LKKD+DA +++ EL+ K +L +
Sbjct: 238 ELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 216 MKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSR 275
++ +Y+ EL + + D SV + MD+ ++DL I+ EVKAQY+ +A RS EAE++ +
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQ 357
Query: 276 SQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGE 335
++ EE + +G L++++ EIA++N IQ+LRS+I VK C L+ I AE++GE
Sbjct: 358 TKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGE 417
Query: 336 LAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMD 395
+A +DAK KL LE ALQ+AKQD+AR L++YQELMNVKLALD+EIATYRKL+EGEE R++
Sbjct: 418 MALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLN 477
Query: 396 SPSA--TVVSAVQS 407
+S VQS
Sbjct: 478 GEGVGQVNISVVQS 491
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 315 bits (806), Expect = 6e-86
Identities = 169/371 (45%), Positives = 252/371 (67%), Gaps = 6/371 (1%)
Query: 53 GTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLE 112
G I +VT+N LL PL+V++DP + Q+K QE+E++K LN+KFAS I KV+ LEQ+N++LE
Sbjct: 168 GGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLE 227
Query: 113 TRWSFLQGQDSAIF----DLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFR 168
T+W+ LQ Q ++ +L L+E + L+ L + ERG+L++ L + + VE+F+
Sbjct: 228 TKWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFK 287
Query: 169 IRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLA 228
+YEDEI+KRT E FV LKKD+D+ +++ EL+ K+ +L ++ ++T+Y+ EL +
Sbjct: 288 KKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQ 347
Query: 229 AQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEY 288
+ + D SV + MD+ +DL I+ EV+AQY+ +A RS EAEA +++L E + +
Sbjct: 348 SHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRH 407
Query: 289 GSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQL 348
G L++++SEI +LN IQ+LR++I VK L+ I AE+ GE+A +DA KL +L
Sbjct: 408 GDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQEL 467
Query: 349 EAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM--DSPSATVVSAVQ 406
+AALQQAK D+AR LR YQELMNVKLALD+EIATYRKL+EGEE RM + PSA +S V
Sbjct: 468 QAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVS 527
Query: 407 SRCKTAPSLPY 417
S +A + Y
Sbjct: 528 SSTTSASAGGY 538
>gi|32567786 keratin 6L [Homo sapiens]
Length = 535
Score = 310 bits (793), Expect = 2e-84
Identities = 167/383 (43%), Positives = 253/383 (66%), Gaps = 6/383 (1%)
Query: 27 GTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEE 86
G G+ S G G ++ G I +VTVN LL PL V++DP +Q+++ QE+E+
Sbjct: 86 GGFGFGSRAFMGQGAGRQTFGPACPPGGIQEVTVNQSLLTPLHVEIDPEIQRVRTQEREQ 145
Query: 87 MKALNDKFASLIGKVQALEQRNQLLETRWSFLQ--GQDSAIF--DLGHLYEEYQGRLQEE 142
+K LN+KFAS I KV+ LEQ+N++LET+W+ LQ GQ+ + +L L+E Y G ++
Sbjct: 146 IKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGQNLGVTRNNLEPLFEAYLGSMRST 205
Query: 143 LRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTEL 202
L ++ ERG+L++ L V + VE+F+ +YEDEI+K T E FV LKKD+DA + R +L
Sbjct: 206 LDRLQSERGRLDSELRNVQDLVEDFKNKYEDEINKHTAAENEFVVLKKDVDAAYMGRMDL 265
Query: 203 ETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAV 262
K+ +L ++ ++ +YE EL + V + +V + MD+ ++DL I+ EVKAQY+ +
Sbjct: 266 HGKVGTLTQEIDFLQQLYEMELSQVQTHVSNTNVVLSMDNNRNLDLDSIIAEVKAQYELI 325
Query: 263 AARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLK 322
A RS EAEA+ +++ EE + ++G +L+ +++EIA+L IQ+L+ + + K C +
Sbjct: 326 AQRSRAEAEAWYQTKYEELQVTAGKHGDNLRDTKNEIAELTRTIQRLQGEADAAKKQCQQ 385
Query: 323 LEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIAT 382
L+ I AE++GELA +DA+ KL L+ AL QAK+D+ R LR YQELMNVKLALD+EIAT
Sbjct: 386 LQTAIAEAEQRGELALKDAQKKLGDLDVALHQAKEDLTRLLRDYQELMNVKLALDVEIAT 445
Query: 383 YRKLVEGEEGRM--DSPSATVVS 403
YRKL+E EE RM + PSA +S
Sbjct: 446 YRKLLESEESRMSGECPSAVSIS 468
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 308 bits (790), Expect = 5e-84
Identities = 171/366 (46%), Positives = 242/366 (66%), Gaps = 4/366 (1%)
Query: 53 GTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLE 112
G I +V VN LL PL+V++DP + Q+K QE+E++K LN+KFAS I KV+ LEQ+N++LE
Sbjct: 153 GGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLE 212
Query: 113 TRWSFLQGQD--SAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIR 170
T+W LQ Q S L +E Y L ++L + ERG LE L + + VE+F+ +
Sbjct: 213 TKWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKK 272
Query: 171 YEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQ 230
YEDEI+KRT E FV LKKD+DA +++ EL+ K+ SL V ++T+YE EL + +
Sbjct: 273 YEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSH 332
Query: 231 VKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGS 290
D SV + MD+ +DL I+ EV+AQY+ +A RS EAEA +++L E + +G
Sbjct: 333 ASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGD 392
Query: 291 SLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEA 350
L++++SEI +LN IQ+LR++I +VK L+ I AE++GE+A +DA KL L+
Sbjct: 393 DLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQT 452
Query: 351 ALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM--DSPSATVVSAVQSR 408
ALQ+AK D+AR LR YQELMNVKLALD+EIATYRKL+EGEE RM + SA +S V +
Sbjct: 453 ALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNV 512
Query: 409 CKTAPS 414
T+ S
Sbjct: 513 TSTSGS 518
>gi|28173564 keratin 73 [Homo sapiens]
Length = 540
Score = 305 bits (782), Expect = 4e-83
Identities = 160/353 (45%), Positives = 242/353 (68%), Gaps = 2/353 (0%)
Query: 53 GTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLE 112
G I +VT+N LL PL+V+LDP +Q+++ QE+E++K LN+KFAS I KV+ LEQ+NQ+LE
Sbjct: 102 GGIHQVTINKSLLAPLNVELDPEIQKVRAQEREQIKVLNNKFASFIDKVRFLEQQNQVLE 161
Query: 113 TRWSFLQGQD--SAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIR 170
T+W LQ D + +L + E Y L+++L +S +R +L++ L V E VE+++ R
Sbjct: 162 TKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRSVREVVEDYKKR 221
Query: 171 YEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQ 230
YE+EI+KRT E FV LKKD+DA + EL+ K+ +L+ ++ K +YE E + +
Sbjct: 222 YEEEINKRTTAENEFVVLKKDVDAAYTSKVELQAKVDALDGEIKFFKCLYEGETAQIQSH 281
Query: 231 VKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGS 290
+ D S+ + MD+ ++DL I+ EV+AQY+ +A +S EAEA +++ +E + +G
Sbjct: 282 ISDTSIILSMDNNRNLDLDSIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGD 341
Query: 291 SLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEA 350
L+ +++EI++L IQ+LRS+I SVK C LE I AE++G+ A +DA+ KL +LE
Sbjct: 342 DLKHTKNEISELTRLIQRLRSEIESVKKQCANLETAIADAEQRGDCALKDARAKLDELEG 401
Query: 351 ALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVS 403
ALQQAK+++AR LR+YQEL++VKL+LDIEIATYRKL+EGEE RM VS
Sbjct: 402 ALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVS 454
>gi|27477127 keratin 82 [Homo sapiens]
Length = 513
Score = 305 bits (781), Expect = 5e-83
Identities = 167/382 (43%), Positives = 251/382 (65%), Gaps = 2/382 (0%)
Query: 13 LSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKL 72
L S + VG RP + C PGF R C + I+ VT+N LLVPL +++
Sbjct: 52 LGSRSLCNVGFGRPRVAS--RCGGTLPGFGYRLGATCGPSACITPVTINESLLVPLALEI 109
Query: 73 DPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLY 132
DP VQ++K EKE++K LN++FAS I KV+ LEQ+N+LLET+W+F+Q Q ++ ++
Sbjct: 110 DPTVQRVKRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRCCQTNIEPIF 169
Query: 133 EEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDL 192
E Y L+ +L VS +R +LE+ L + +E ++ +YE+E+S R +E FV LKKD+
Sbjct: 170 EGYISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCVENEFVALKKDV 229
Query: 193 DAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIV 252
D L + +LET ++L ++ +K++YE+E+ L +Q+ + SV V MD+ +D+ GI+
Sbjct: 230 DTAFLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNSRELDVDGII 289
Query: 253 EEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQ 312
E+KAQYD +A+RS EAEA+ + + EE + + +L++ ++EI ++N IQ+L+ +
Sbjct: 290 AEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQE 349
Query: 313 ILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNV 372
+VK+ KLE I AE+QGE A DAK KLA LE ALQ+AKQDMA L++YQE+MN
Sbjct: 350 TENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNS 409
Query: 373 KLALDIEIATYRKLVEGEEGRM 394
KL LDIEIATYR+L+EGEE R+
Sbjct: 410 KLGLDIEIATYRRLLEGEEHRL 431
>gi|28372503 keratin 72 isoform 1 [Homo sapiens]
Length = 511
Score = 304 bits (778), Expect = 1e-82
Identities = 167/407 (41%), Positives = 266/407 (65%), Gaps = 7/407 (1%)
Query: 5 SCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTVNPGL 64
SC+ G SL+ G R G G+ G + + C G I +VTVN L
Sbjct: 50 SCLGGSRSLALSAAARRGGGRLG--GFVGTAFGSAGLGPKCPSVC-PPGGIPQVTVNKSL 106
Query: 65 LVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQD-- 122
L PL+V++DP +Q+++ QE+E++KALN+KFAS I KV+ LEQ+NQ+LET+W+ LQ D
Sbjct: 107 LAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWNLLQQLDLN 166
Query: 123 SAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDME 182
+ +L +YE Y LQ++L +S + +L++ L + + VE+++ RYE EI++RT E
Sbjct: 167 NCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSELRNMQDLVEDYKKRYEVEINRRTAAE 226
Query: 183 FTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDS 242
FV LKKD+DA +++ EL+ K+ SL ++ K +YE E+ + + + D S+ + MD+
Sbjct: 227 NEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDN 286
Query: 243 RCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADL 302
+DL I+ EV+AQY+ +A +S EAE +++++E + ++G L+ +++EI++L
Sbjct: 287 NRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEISEL 346
Query: 303 NVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQ 362
N IQ++RS+I +VK C LE I AE++G+ A +DA+ KL +LE AL QAK+++AR
Sbjct: 347 NRLIQRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARAKLDELEGALHQAKEELARM 406
Query: 363 LRKYQELMNVKLALDIEIATYRKLVEGEEGRM--DSPSATVVSAVQS 407
LR+YQEL+++KLALD+EIATYRKL+E EE RM + P++ +S + S
Sbjct: 407 LREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVISS 453
>gi|226246663 keratin 72 isoform 1 [Homo sapiens]
Length = 511
Score = 304 bits (778), Expect = 1e-82
Identities = 167/407 (41%), Positives = 266/407 (65%), Gaps = 7/407 (1%)
Query: 5 SCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTVNPGL 64
SC+ G SL+ G R G G+ G + + C G I +VTVN L
Sbjct: 50 SCLGGSRSLALSAAARRGGGRLG--GFVGTAFGSAGLGPKCPSVC-PPGGIPQVTVNKSL 106
Query: 65 LVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQD-- 122
L PL+V++DP +Q+++ QE+E++KALN+KFAS I KV+ LEQ+NQ+LET+W+ LQ D
Sbjct: 107 LAPLNVEMDPEIQRVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWNLLQQLDLN 166
Query: 123 SAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDME 182
+ +L +YE Y LQ++L +S + +L++ L + + VE+++ RYE EI++RT E
Sbjct: 167 NCRKNLEPIYEGYISNLQKQLEMLSGDGVRLDSELRNMQDLVEDYKKRYEVEINRRTAAE 226
Query: 183 FTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDS 242
FV LKKD+DA +++ EL+ K+ SL ++ K +YE E+ + + + D S+ + MD+
Sbjct: 227 NEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDN 286
Query: 243 RCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADL 302
+DL I+ EV+AQY+ +A +S EAE +++++E + ++G L+ +++EI++L
Sbjct: 287 NRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEISEL 346
Query: 303 NVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQ 362
N IQ++RS+I +VK C LE I AE++G+ A +DA+ KL +LE AL QAK+++AR
Sbjct: 347 NRLIQRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARAKLDELEGALHQAKEELARM 406
Query: 363 LRKYQELMNVKLALDIEIATYRKLVEGEEGRM--DSPSATVVSAVQS 407
LR+YQEL+++KLALD+EIATYRKL+E EE RM + P++ +S + S
Sbjct: 407 LREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVISS 453
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 303 bits (776), Expect = 2e-82
Identities = 163/358 (45%), Positives = 243/358 (67%), Gaps = 1/358 (0%)
Query: 38 GPGFSSR-SLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFAS 96
GPGF R G +A +I+ VTVN LL PL++++DP Q++K EKE++K LN+KFAS
Sbjct: 119 GPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFAS 178
Query: 97 LIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEAN 156
I KV+ LEQ+N+LLET+WSFLQ Q +L L+E Y L+ +L + ++ +L+A
Sbjct: 179 FIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITNLRRQLEVLVSDQARLQAE 238
Query: 157 LLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELM 216
+ + +E F+ +YE+E+ R + E FV LKKD+DA +++++LE + +L ++ +
Sbjct: 239 RNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMNKSDLEANVDTLTQEIDFL 298
Query: 217 KTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRS 276
KT+Y +E++ L + + + SV V MD+ ++L GI+ EVKAQY+ VA RS +AEA+ ++
Sbjct: 299 KTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADAEAWYQT 358
Query: 277 QLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGEL 336
+ EE + ++ +L++ R+EI +L IQ+L+++I K+ KLE + AE+QGE
Sbjct: 359 KYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQRAKLEAAVAEAEQQGEA 418
Query: 337 AFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM 394
DAK KLA LE ALQQAKQDMARQL +YQELMN KL LDIEIATYR+L+EGEE R+
Sbjct: 419 TLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEIATYRRLLEGEESRL 476
Score = 32.0 bits (71), Expect = 1.1
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 3/101 (2%)
Query: 138 RLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECL 197
RL+ E+ +R +LEA V E ++ D K D+E Q K+D+ +
Sbjct: 390 RLKAEIEHAKAQRAKLEA---AVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLC 446
Query: 198 HRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTV 238
EL L+ + + + E E L V V+++V
Sbjct: 447 EYQELMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISV 487
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 303 bits (775), Expect = 3e-82
Identities = 157/364 (43%), Positives = 247/364 (67%), Gaps = 2/364 (0%)
Query: 53 GTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLE 112
G I +VT+N LL PL+V++DP +Q++K++E+E++K+LN++FAS I KV+ LEQ+NQ+L+
Sbjct: 150 GGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQ 209
Query: 113 TRWSFLQGQDSAI--FDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIR 170
T+W LQ D++ +L +E + L+ + ++ ++ +L++ L + + VE++R +
Sbjct: 210 TKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNK 269
Query: 171 YEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQ 230
YEDEI+KRT+ E FV +KKD+D + + +L+ KL +L+ ++ + +Y+ EL + Q
Sbjct: 270 YEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQ 329
Query: 231 VKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGS 290
+ + +V + MD+ +DL I+ EVKAQY+ +A +S EAE+ +S+ EE + +G
Sbjct: 330 ISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGD 389
Query: 291 SLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEA 350
S+++S+ EI++LN IQ+LRS+I +VK L+++I AE++GE A +DAK KL LE
Sbjct: 390 SVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLED 449
Query: 351 ALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCK 410
ALQQAK+D+AR LR YQELMN KLALD+EIATYR L+EGEE RM A VS S
Sbjct: 450 ALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSVSTSH 509
Query: 411 TAPS 414
T S
Sbjct: 510 TTIS 513
>gi|15618995 keratin 71 [Homo sapiens]
Length = 523
Score = 300 bits (767), Expect = 2e-81
Identities = 168/398 (42%), Positives = 265/398 (66%), Gaps = 13/398 (3%)
Query: 22 GSPRPGTSGWDSCRAPGPG---FSSRSL-----TGCWSAGTISKVTVNPGLLVPLDVKLD 73
GS + G G+ RA G F S +L T C G I +VTVN LL PL+V+LD
Sbjct: 62 GSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTVC-PPGGIHQVTVNESLLAPLNVELD 120
Query: 74 PAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQD--SAIFDLGHL 131
P +Q+++ QE+E++KALN+KFAS I KV+ LEQ+NQ+LET+W LQ D + +L +
Sbjct: 121 PEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPI 180
Query: 132 YEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKD 191
E Y L+++L +S +R +L++ L V + VE+++ RYE+EI+KRT E FV LKKD
Sbjct: 181 LEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKD 240
Query: 192 LDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGI 251
+DA ++ EL+ K++S++ ++ + ++E E+ + + + D+SV + MD+ ++DL I
Sbjct: 241 VDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSI 300
Query: 252 VEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRS 311
++EV+ QY+ +A +S EAEA +++ +E + +G L+++++EI++L IQ++RS
Sbjct: 301 IDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRS 360
Query: 312 QILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMN 371
+I +VK LE I AE++G+ A +DA+ KL +LE AL QAK+++AR LR+YQELM+
Sbjct: 361 EIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMS 420
Query: 372 VKLALDIEIATYRKLVEGEEGRM--DSPSATVVSAVQS 407
+KLALD+EIATYRKL+E EE RM + PS +S + S
Sbjct: 421 LKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISS 458
>gi|47132620 keratin 2 [Homo sapiens]
Length = 639
Score = 297 bits (760), Expect = 1e-80
Identities = 164/359 (45%), Positives = 235/359 (65%), Gaps = 4/359 (1%)
Query: 53 GTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLE 112
G I +V+VN LL PL+VK+DP +Q +K QE+E++K LN+KFAS I KV+ LEQ+NQ+L+
Sbjct: 148 GGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQ 207
Query: 113 TRWSFLQGQDSAI--FDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIR 170
T+W LQ + +L +++ Y L+ L ++ ER + L + + VE+++ +
Sbjct: 208 TKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKK 267
Query: 171 YEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQ 230
YEDEI+KRT E FV LKKD+D + + EL++K+ L +E +K +Y+ E+ +
Sbjct: 268 YEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQS 327
Query: 231 VKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGS 290
V D +V + MD+ ++DL I+ EVKAQY+ +A RS EEAEA S+ EE +G
Sbjct: 328 VTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGD 387
Query: 291 SLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEA 350
SL+ + EI++LN IQ+L+ +I VK C +++ I AE++GE A +DA+ KL LE
Sbjct: 388 SLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEE 447
Query: 351 ALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM--DSPSATVVSAVQS 407
ALQQAK+D+AR LR YQELMNVKLALD+EIATYRKL+EGEE RM D S VS S
Sbjct: 448 ALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSS 506
>gi|4504935 keratin 85 [Homo sapiens]
Length = 507
Score = 295 bits (756), Expect = 4e-80
Identities = 173/410 (42%), Positives = 254/410 (61%), Gaps = 7/410 (1%)
Query: 1 MACRSCVVGFSSLSSCEVTPVGSPRPGTSGW--DSCRAPGPGFSSRSLTGCW-SAGTISK 57
++C + GF S S C + G PR G+ SC G F RS C S I+
Sbjct: 42 VSCYRGLTGFGSRSLCNLGSCG-PRIAVGGFRAGSC---GRSFGYRSGGVCGPSPPCITT 97
Query: 58 VTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSF 117
V+VN LL PL++++DP Q +K +EKE++K+LN +FA+ I KV+ LEQ+N+LLET+W F
Sbjct: 98 VSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQF 157
Query: 118 LQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISK 177
Q Q +L L+ Y L+ E V + G+L + L V E +E ++ +YE+E++
Sbjct: 158 YQNQRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVAL 217
Query: 178 RTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVT 237
R E FV LKKD+D L +++LE +++L ++ +YE+E++ L A + D SV
Sbjct: 218 RATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVI 277
Query: 238 VGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRS 297
V MD+ +++ I+ E+KAQYD VA+RS EAE++ RS+ EE A +G +L+ ++
Sbjct: 278 VKMDNSRDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKE 337
Query: 298 EIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQ 357
EI +LN IQ+L ++I + K KLE + AE+QGE A DA+ KLA+LE ALQ+AKQ
Sbjct: 338 EINELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQ 397
Query: 358 DMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQS 407
DMA L++YQE+MN KL LDIEIATYR+L+EGEE R+ +V V S
Sbjct: 398 DMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNVCVSS 447
>gi|148612803 keratin 6 irs4 [Homo sapiens]
Length = 529
Score = 295 bits (754), Expect = 7e-80
Identities = 169/394 (42%), Positives = 258/394 (65%), Gaps = 12/394 (3%)
Query: 25 RPGTSGWDSCRAPGPG---FSSRSL-TGCWSA---GTISKVTVNPGLLVPLDVKLDPAVQ 77
RPG SG+ RA G F S +L C S G I +VTVN LL PL+V+LDP +Q
Sbjct: 76 RPG-SGYGGGRASGFAGSMFGSVALGPACLSVCPPGGIHQVTVNKSLLAPLNVELDPEIQ 134
Query: 78 QLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQD--SAIFDLGHLYEEY 135
+++ QE+E++K LNDKFAS I KV+ LEQ+NQ+LET+W LQ D + +L + E Y
Sbjct: 135 KVRAQEREQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGY 194
Query: 136 QGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAE 195
L+++L +S +R +L++ L + + VE+++ RYE EI++RT E FV LKKD DA
Sbjct: 195 ISNLRKQLETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAA 254
Query: 196 CLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEV 255
+ EL+ K+ SL+ ++ +K +Y+ E+ + + SV + MD+ +DL I+ EV
Sbjct: 255 YAVKVELQAKVDSLDKEIKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEV 314
Query: 256 KAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILS 315
+ Y+ +A +S EAEA +++++E ++ +G L+ +RSE+ +LN IQ++R +I +
Sbjct: 315 RMHYEEIALKSKAEAEALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGN 374
Query: 316 VKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLA 375
VK LE I AE++G+ A +DA+ KL +LE AL QAK+++AR LR+YQELM++KLA
Sbjct: 375 VKKQRASLETAIADAEQRGDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLA 434
Query: 376 LDIEIATYRKLVEGEEGRM--DSPSATVVSAVQS 407
LD+EIATYRKL+EGEE RM ++PS+ +S + S
Sbjct: 435 LDMEIATYRKLLEGEECRMSGENPSSVSISVISS 468
>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 486
Score = 287 bits (734), Expect = 1e-77
Identities = 170/436 (38%), Positives = 258/436 (59%), Gaps = 35/436 (8%)
Query: 1 MACRSCVVG--FSSLSSCEVTPVGSPRPGTS--------GWDSCRAPGPGFSSRSLTGCW 50
M C S G FS +S+C PRPG G R GF S S+ G +
Sbjct: 1 MTCGSYCGGRAFSCISAC------GPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGF 54
Query: 51 SAGT-------------------ISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALN 91
AG+ I+ V+VN LL PL++++DP Q +K +EKE++K+LN
Sbjct: 55 RAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLN 114
Query: 92 DKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERG 151
+FA+ I KV+ LEQ+N+LLET+ F Q ++ +L L+E Y L+ E V + G
Sbjct: 115 SRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSG 174
Query: 152 QLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLES 211
+L + L V E +E ++ +YE+E+S R E FV LKKD+D L +++LE +++L
Sbjct: 175 RLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQ 234
Query: 212 FVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAE 271
++ ++ +YE+E++ L + + D SV V +D+ +++ I+ E+KAQYD + RS EAE
Sbjct: 235 EIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAE 294
Query: 272 AYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAE 331
++ RS+ EE A +G +L+ ++ EI +LN IQ+L +++ + K KLE + +E
Sbjct: 295 SWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSE 354
Query: 332 EQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEE 391
+QGE A DA+ KLA+LE ALQ+AKQDMA +R+YQE+MN KL LDIEIATYR+L+EGEE
Sbjct: 355 QQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEE 414
Query: 392 GRMDSPSATVVSAVQS 407
R+ +V V S
Sbjct: 415 QRLCEGVGSVNVCVSS 430
>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 486
Score = 287 bits (734), Expect = 1e-77
Identities = 170/436 (38%), Positives = 258/436 (59%), Gaps = 35/436 (8%)
Query: 1 MACRSCVVG--FSSLSSCEVTPVGSPRPGTS--------GWDSCRAPGPGFSSRSLTGCW 50
M C S G FS +S+C PRPG G R GF S S+ G +
Sbjct: 1 MTCGSYCGGRAFSCISAC------GPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGF 54
Query: 51 SAGT-------------------ISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALN 91
AG+ I+ V+VN LL PL++++DP Q +K +EKE++K+LN
Sbjct: 55 RAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLN 114
Query: 92 DKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERG 151
+FA+ I KV+ LEQ+N+LLET+ F Q ++ +L L+E Y L+ E V + G
Sbjct: 115 SRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSG 174
Query: 152 QLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLES 211
+L + L V E +E ++ +YE+E+S R E FV LKKD+D L +++LE +++L
Sbjct: 175 RLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQ 234
Query: 212 FVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAE 271
++ ++ +YE+E++ L + + D SV V +D+ +++ I+ E+KAQYD + RS EAE
Sbjct: 235 EIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAE 294
Query: 272 AYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAE 331
++ RS+ EE A +G +L+ ++ EI +LN IQ+L +++ + K KLE + +E
Sbjct: 295 SWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSE 354
Query: 332 EQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEE 391
+QGE A DA+ KLA+LE ALQ+AKQDMA +R+YQE+MN KL LDIEIATYR+L+EGEE
Sbjct: 355 QQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEE 414
Query: 392 GRMDSPSATVVSAVQS 407
R+ +V V S
Sbjct: 415 QRLCEGVGSVNVCVSS 430
>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
sapiens]
Length = 486
Score = 287 bits (734), Expect = 1e-77
Identities = 170/436 (38%), Positives = 258/436 (59%), Gaps = 35/436 (8%)
Query: 1 MACRSCVVG--FSSLSSCEVTPVGSPRPGTS--------GWDSCRAPGPGFSSRSLTGCW 50
M C S G FS +S+C PRPG G R GF S S+ G +
Sbjct: 1 MTCGSYCGGRAFSCISAC------GPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGF 54
Query: 51 SAGT-------------------ISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALN 91
AG+ I+ V+VN LL PL++++DP Q +K +EKE++K+LN
Sbjct: 55 RAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLN 114
Query: 92 DKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERG 151
+FA+ I KV+ LEQ+N+LLET+ F Q ++ +L L+E Y L+ E V + G
Sbjct: 115 SRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSG 174
Query: 152 QLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLES 211
+L + L V E +E ++ +YE+E+S R E FV LKKD+D L +++LE +++L
Sbjct: 175 RLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQ 234
Query: 212 FVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAE 271
++ ++ +YE+E++ L + + D SV V +D+ +++ I+ E+KAQYD + RS EAE
Sbjct: 235 EIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAE 294
Query: 272 AYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAE 331
++ RS+ EE A +G +L+ ++ EI +LN IQ+L +++ + K KLE + +E
Sbjct: 295 SWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSE 354
Query: 332 EQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEE 391
+QGE A DA+ KLA+LE ALQ+AKQDMA +R+YQE+MN KL LDIEIATYR+L+EGEE
Sbjct: 355 QQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEE 414
Query: 392 GRMDSPSATVVSAVQS 407
R+ +V V S
Sbjct: 415 QRLCEGVGSVNVCVSS 430
>gi|14318422 keratin 86 [Homo sapiens]
Length = 486
Score = 287 bits (734), Expect = 1e-77
Identities = 170/436 (38%), Positives = 258/436 (59%), Gaps = 35/436 (8%)
Query: 1 MACRSCVVG--FSSLSSCEVTPVGSPRPGTS--------GWDSCRAPGPGFSSRSLTGCW 50
M C S G FS +S+C PRPG G R GF S S+ G +
Sbjct: 1 MTCGSYCGGRAFSCISAC------GPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGF 54
Query: 51 SAGT-------------------ISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALN 91
AG+ I+ V+VN LL PL++++DP Q +K +EKE++K+LN
Sbjct: 55 RAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLN 114
Query: 92 DKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERG 151
+FA+ I KV+ LEQ+N+LLET+ F Q ++ +L L+E Y L+ E V + G
Sbjct: 115 SRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSG 174
Query: 152 QLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLES 211
+L + L V E +E ++ +YE+E+S R E FV LKKD+D L +++LE +++L
Sbjct: 175 RLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQ 234
Query: 212 FVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAE 271
++ ++ +YE+E++ L + + D SV V +D+ +++ I+ E+KAQYD + RS EAE
Sbjct: 235 EIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAE 294
Query: 272 AYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAE 331
++ RS+ EE A +G +L+ ++ EI +LN IQ+L +++ + K KLE + +E
Sbjct: 295 SWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSE 354
Query: 332 EQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEE 391
+QGE A DA+ KLA+LE ALQ+AKQDMA +R+YQE+MN KL LDIEIATYR+L+EGEE
Sbjct: 355 QQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEE 414
Query: 392 GRMDSPSATVVSAVQS 407
R+ +V V S
Sbjct: 415 QRLCEGVGSVNVCVSS 430
>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
Length = 505
Score = 285 bits (728), Expect = 7e-77
Identities = 167/423 (39%), Positives = 253/423 (59%), Gaps = 35/423 (8%)
Query: 1 MACRSCVVG--FSSLSSCEVTPVGSPRPGTS--------GWDSCRAPGPGFSSRSLTGCW 50
M C S G FS +S+C PRPG G R GF S S+ G +
Sbjct: 1 MTCGSGFGGRAFSCISAC------GPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGF 54
Query: 51 SAGT-------------------ISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALN 91
AG+ I+ V+VN LL PL++++DP Q +K +EKE++K+LN
Sbjct: 55 RAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLN 114
Query: 92 DKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERG 151
+FA+ I KV+ LEQ+N+LLET+ F Q ++ +L L+E Y L+ E V + G
Sbjct: 115 SRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSG 174
Query: 152 QLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLES 211
+L + L V E +E ++ +YE+E+S R E FV LKKD+D L +++LE +++L
Sbjct: 175 RLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQ 234
Query: 212 FVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAE 271
++ ++ +YE+E+ L + + D SV V +D+ +++ I+ E+KAQYD + RS EAE
Sbjct: 235 EIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAE 294
Query: 272 AYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAE 331
++ RS+ EE A +G +L+ ++ EI +LN IQ+L +++ + K KLE + +E
Sbjct: 295 SWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSE 354
Query: 332 EQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEE 391
+QGE A DA+ KLA+LE ALQ+AKQDMA +R+YQE+MN KL LDIEIATYR+L+EGEE
Sbjct: 355 QQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEE 414
Query: 392 GRM 394
R+
Sbjct: 415 QRL 417
>gi|169790841 keratin 83 [Homo sapiens]
Length = 493
Score = 282 bits (722), Expect = 4e-76
Identities = 162/409 (39%), Positives = 251/409 (61%), Gaps = 27/409 (6%)
Query: 10 FSSLSSCEVTP-----VGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGT---------- 54
FS +S+C P +P G S + R GF S S+ G + AG+
Sbjct: 17 FSCVSACGPRPSRCCITAAPYRGISCY---RGLTGGFGSHSVCGGFRAGSCGRSFGYRSG 73
Query: 55 ---------ISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALE 105
I+ V+VN LL PL++++DP Q +K +EKE++K+LN +FA+ I KV+ LE
Sbjct: 74 GVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLE 133
Query: 106 QRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVE 165
Q+N+LLET+ F Q ++ +L L+ Y L+ E V + G+L + L V E +E
Sbjct: 134 QQNKLLETKLQFYQNRECCQSNLEPLFAGYIETLRREAECVEADSGRLASELNHVQEVLE 193
Query: 166 EFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELK 225
++ +YE+E++ R E FV LKKD+D L +++LE +++L ++ ++ +YE+E++
Sbjct: 194 GYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIR 253
Query: 226 DLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARS 285
L + + D SV V +D+ +++ IV E+KAQYD +A RS EAE++ RS+ EE A
Sbjct: 254 ILQSHISDTSVVVKLDNSRDLNMDCIVAEIKAQYDDIATRSRAEAESWYRSKCEEMKATV 313
Query: 286 AEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKL 345
+G +L+ ++ EI +LN IQ+L +++ + K KLE + +E+QGE A DA+ KL
Sbjct: 314 IRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKL 373
Query: 346 AQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM 394
A+LE ALQ+AKQDMA +R+YQE+MN KL LDIEIATYR+L+EGEE R+
Sbjct: 374 AELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRL 422
>gi|194018511 keratin 77 [Homo sapiens]
Length = 578
Score = 281 bits (719), Expect = 8e-76
Identities = 156/388 (40%), Positives = 244/388 (62%), Gaps = 5/388 (1%)
Query: 21 VGSPRPGTSGWDSCRAPGPGFSSRSLTGCWS---AGTISKVTVNPGLLVPLDVKLDPAVQ 77
VGS G G G G S+ L G G I +VT+N LL PL +++DP +Q
Sbjct: 99 VGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQ 158
Query: 78 QLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQ--GQDSAIFDLGHLYEEY 135
++K QE+E++ LN+KFAS I KV+ LEQ+NQ+L+T+W LQ + +L L E Y
Sbjct: 159 RIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENY 218
Query: 136 QGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAE 195
G L+ ++ +S E+ + A + + + VE+++ +YEDEI+KRT E FV LKKD+DA
Sbjct: 219 IGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAA 278
Query: 196 CLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEV 255
+ + +LE+++ +L V +K ++ EL + + D +V + MD+ +DL I++ V
Sbjct: 279 YVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAV 338
Query: 256 KAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILS 315
+ QY+ +A RS +EAEA +++ +E + +G L++S+ EIA+LN +Q+L+++I +
Sbjct: 339 RTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISN 398
Query: 316 VKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLA 375
VK +++ I AEE+GE A QDA KL LE ALQQ+K+++AR LR YQ ++ VKL+
Sbjct: 399 VKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLS 458
Query: 376 LDIEIATYRKLVEGEEGRMDSPSATVVS 403
LD+EIATYR+L+EGEE RM + VS
Sbjct: 459 LDVEIATYRQLLEGEESRMSGELQSHVS 486
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,561,779
Number of Sequences: 37866
Number of extensions: 644639
Number of successful extensions: 5160
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 216
Number of HSP's successfully gapped in prelim test: 569
Number of HSP's that attempted gapping in prelim test: 3014
Number of HSP's gapped (non-prelim): 1813
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.