Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 124256480
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
(607 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 1209 0.0
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 1161 0.0
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 415 e-116
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 135 8e-32
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 116 5e-26
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 116 5e-26
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 116 5e-26
gi|26665869 WD repeat domain 51B [Homo sapiens] 116 7e-26
gi|23199987 WD repeat domain 5B [Homo sapiens] 115 1e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 111 2e-24
gi|16554627 WD repeat domain 5 [Homo sapiens] 111 2e-24
gi|32189425 WD repeat domain 69 [Homo sapiens] 107 4e-23
gi|19913369 transducin beta-like 3 [Homo sapiens] 94 3e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 90 5e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 2e-17
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 89 2e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 88 3e-17
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 87 3e-17
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 86 8e-17
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 86 8e-17
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 86 8e-17
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 86 8e-17
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] 86 1e-16
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] 86 1e-16
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] 86 1e-16
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 84 3e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 84 3e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 84 3e-16
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 83 8e-16
gi|19913367 transducin beta-like 1Y [Homo sapiens] 82 1e-15
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 1209 bits (3129), Expect = 0.0
Identities = 607/607 (100%), Positives = 607/607 (100%)
Query: 1 MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEK 60
MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEK
Sbjct: 1 MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEK 60
Query: 61 HDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRK 120
HDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRK
Sbjct: 61 HDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRK 120
Query: 121 DREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKL 180
DREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKL
Sbjct: 121 DREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKL 180
Query: 181 RKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
RKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI
Sbjct: 181 RKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
Query: 241 EVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLDSITNIFGRRSVSSFPVPQDNVDT 300
EVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLDSITNIFGRRSVSSFPVPQDNVDT
Sbjct: 241 EVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLDSITNIFGRRSVSSFPVPQDNVDT 300
Query: 301 HPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKG 360
HPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKG
Sbjct: 301 HPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKG 360
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDN 420
SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDN
Sbjct: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDN 420
Query: 421 ARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 480
ARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES
Sbjct: 421 ARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 480
Query: 481 IVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV 540
IVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV
Sbjct: 481 IVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV 540
Query: 541 VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCK 600
VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCK
Sbjct: 541 VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCK 600
Query: 601 AVLWAQY 607
AVLWAQY
Sbjct: 601 AVLWAQY 607
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 1161 bits (3004), Expect = 0.0
Identities = 588/607 (96%), Positives = 588/607 (96%), Gaps = 19/607 (3%)
Query: 1 MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEK 60
MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEK
Sbjct: 1 MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEK 60
Query: 61 HDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRK 120
HDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRK
Sbjct: 61 HDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRK 120
Query: 121 DREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKL 180
DREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKL
Sbjct: 121 DREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKL 180
Query: 181 RKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
RKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI
Sbjct: 181 RKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
Query: 241 EVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLDSITNIFGRRSVSSFPVPQDNVDT 300
EVIVDETSDHTEETSPVRAISRAAT RRSVSSFPVPQDNVDT
Sbjct: 241 EVIVDETSDHTEETSPVRAISRAAT-------------------RRSVSSFPVPQDNVDT 281
Query: 301 HPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKG 360
HPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKG
Sbjct: 282 HPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKG 341
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDN 420
SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDN
Sbjct: 342 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDN 401
Query: 421 ARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 480
ARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES
Sbjct: 402 ARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 461
Query: 481 IVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV 540
IVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV
Sbjct: 462 IVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV 521
Query: 541 VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCK 600
VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCK
Sbjct: 522 VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCK 581
Query: 601 AVLWAQY 607
AVLWAQY
Sbjct: 582 AVLWAQY 588
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 415 bits (1067), Expect = e-116
Identities = 239/618 (38%), Positives = 348/618 (56%), Gaps = 21/618 (3%)
Query: 4 GLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDV 63
G+ A RWKRHI QLR RDR Q+ F E++ YN LLEK++L ++KLQ E + V
Sbjct: 5 GVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSV 64
Query: 64 -PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDR 122
P H+ P + + +Q+ + LR+K QEE L GE+A V++ + +
Sbjct: 65 TPTTHQ-GPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLES 123
Query: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
E+Q ++++A ++ L ++ + N + Y+AL+ E LR+
Sbjct: 124 ELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRR 183
Query: 183 TTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEV 242
EE ++L+ R + KA+ A N NE+ R +QAR+ +EL +AAK + + + D
Sbjct: 184 LQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPD--T 241
Query: 243 IVDETSDHTE------ETSPVRAISRAATKRLSQPAGG----------LLDSITNIFGRR 286
+ D + E E P+ + KR + A ++ + + RR
Sbjct: 242 LGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRR 301
Query: 287 SVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRV 346
S P+ P R+P A V DAH EVNAV+F P S LLATGG DR +
Sbjct: 302 GHSIGGAPEQRYQIIPVC-VAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLI 360
Query: 347 KLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTG 406
LW V G + E +L G+ ITS++FD +G +LAA+ + A+++W V + + + TL+G
Sbjct: 361 HLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSG 420
Query: 407 HSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGH 466
H KV +AKF L + V+GS DRT+K WDL C +T+ S CND+VC + ++SGH
Sbjct: 421 HKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGH 480
Query: 467 FDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTF 526
D+KIRFWD R + + + G++T+L L+ ++ LLSCSRD+ LKVIDLR + I+Q F
Sbjct: 481 NDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF 540
Query: 527 SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWS 586
A GFKCGSDWT+ VFSPD SY AGS +G+LYIW V TGK+E L H +++NAVAW
Sbjct: 541 RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC 600
Query: 587 PSGSHVVSVDKGCKAVLW 604
SGSH+VSVD+G K VLW
Sbjct: 601 YSGSHMVSVDQGRKVVLW 618
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 135 bits (341), Expect = 8e-32
Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 30/318 (9%)
Query: 302 PGSGKEVRVPATAL--------------CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVK 347
PG+G++ P L + H+GEV +F P LA+ G DR +
Sbjct: 32 PGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLIL 91
Query: 348 LWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGH 407
LW V+G+ C+ +L G + + + +++ GS L +AS D +W + L GH
Sbjct: 92 LWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH 150
Query: 408 SGKVLSAKFLLDNARIV-SGSHDRTLKLWDLRSKVCIKTV-----FAGSSCNDIVCTEQC 461
+ V S ++V +GS D T+KLWD+R K I+T + ND T
Sbjct: 151 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND---TSDQ 207
Query: 462 VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCSRDDLLKVIDLRTN 520
++SG D I+ WD+R + M +T L L+ E + LLS + D+ ++V D+R
Sbjct: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
Query: 521 AIKQ----TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQH 576
A K+ F + R +SPDGS +AAGSA+ +Y+W + ++ L H
Sbjct: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGH 326
Query: 577 SSSINAVAWSPSGSHVVS 594
+ SIN VA+ P ++S
Sbjct: 327 AGSINEVAFHPDEPIIIS 344
Score = 61.2 bits (147), Expect = 3e-09
Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 21/195 (10%)
Query: 333 GSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAASNDFAS 390
G +L+ TG D VKLW++ + F+ + + ++ F+ +++ D
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDI 217
Query: 391 RIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR----SKVCIKTV 446
++W + +L +T+ GH+ V + + ++S + D T+++WD+R + C+K +
Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK-I 276
Query: 447 FAGSSCNDIVCTEQC--------VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLN 497
F G+ N +C + +G D+ + WD S I+ ++ G I + +
Sbjct: 277 FQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
Query: 498 PERTELLSCSRDDLL 512
P+ ++S S D L
Sbjct: 337 PDEPIIISASSDKRL 351
Score = 49.7 bits (117), Expect = 8e-06
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 6/124 (4%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFG----EKCE--FKGSLSGSNAGITSIEF 374
H V + S L + MD V++W+V E+C F+G++ + +
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
Query: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
GS + A S D +W R+ + L GH+G + F D I+S S D+ L +
Sbjct: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
Query: 435 WDLR 438
+++
Sbjct: 354 GEIQ 357
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 116 bits (291), Expect = 5e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 375
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 74
Query: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 491
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 194
Query: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 250
Query: 552 GSAEGSLYIWS-----VLTGKVEKV 571
G ++ + +W V G+V KV
Sbjct: 251 GGSDEQVMVWKSNFDIVDHGEVTKV 275
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/212 (19%), Positives = 99/212 (46%), Gaps = 9/212 (4%)
Query: 387 DFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW--DLRSKVCIK 444
D +W + + TGH V F + SGS D+T+++W +++ + +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 445 TVFAGSSCNDIVCTE-QCVMSGHFDKKIRFWDIRSESIVREM-ELLGKITALDLNPERTE 502
+ + C++ Q ++ DK ++ W + + + + + + +P+
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 503 LLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWS 562
++S S D +K+ D + ++ + G T V F P G+ +AA + ++ +W
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYC----EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 563 VLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
V T ++ + + HS+++N +++ PSG+++++
Sbjct: 178 VRTHRLLQHY-QLHSAAVNGLSFHPSGNYLIT 208
Score = 31.6 bits (70), Expect = 2.2
Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 10/140 (7%)
Query: 468 DKKIRFWDIRSESIVREMELLGK---ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQ 524
D + W ++ +S R G +T ++ +P L S SRD +++
Sbjct: 2 DSCLMVWHMKPQS--RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
Query: 525 TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVA 584
F A S V F DG S + ++ +W+ K LS QH + +
Sbjct: 60 VFRAHTATVRS----VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLS-QHINWVRCAK 114
Query: 585 WSPSGSHVVSVDKGCKAVLW 604
+SP G +VS LW
Sbjct: 115 FSPDGRLIVSASDDKTVKLW 134
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 116 bits (291), Expect = 5e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 375
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 112
Query: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 491
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
Query: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 288
Query: 552 GSAEGSLYIWS-----VLTGKVEKV 571
G ++ + +W V G+V KV
Sbjct: 289 GGSDEQVMVWKSNFDIVDHGEVTKV 313
Score = 99.8 bits (247), Expect = 7e-21
Identities = 74/294 (25%), Positives = 131/294 (44%), Gaps = 17/294 (5%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377
F H V V FS ++ LA+G MD + +W + + ++ +G +T + F +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPS 72
Query: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
G L + S D RIW + H+ V S F D V+ S D+T+K+W
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 438 RSKVCIKTVFAGSS-CNDIVCTE-----QCVMSGHFDKKIRFWDIRSESIVRE-MELLGK 490
+ K +F+ S N + C + + ++S DK ++ WD S V E G
Sbjct: 133 HRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550
+T +D +P T + + D+ +KV D+RT+ + Q + + F P G+Y+
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLI 245
Query: 551 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
S++ +L I ++ G++ L H VA+S +G + S + ++W
Sbjct: 246 TASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/246 (20%), Positives = 101/246 (41%), Gaps = 53/246 (21%)
Query: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS----S 451
+D L GH V F ++ ++ SGS D L +W ++ + F G +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVT 65
Query: 452 CNDIVCTEQCVMSGHFDKKIRFW--DIRSES--------IVREMELLGK----ITALD-- 495
C + + + SG DK +R W +++ ES VR + +TA D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 496 ---------------------------LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSA 528
+P+ ++S S D +K+ D + ++
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC- 184
Query: 529 PGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPS 588
+ G T V F P G+ +AA + ++ +W V T ++ + + HS+++N +++ PS
Sbjct: 185 ---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPS 240
Query: 589 GSHVVS 594
G+++++
Sbjct: 241 GNYLIT 246
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 116 bits (291), Expect = 5e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 375
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 112
Query: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 491
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
Query: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 288
Query: 552 GSAEGSLYIWS-----VLTGKVEKV 571
G ++ + +W V G+V KV
Sbjct: 289 GGSDEQVMVWKSNFDIVDHGEVTKV 313
Score = 99.8 bits (247), Expect = 7e-21
Identities = 74/294 (25%), Positives = 131/294 (44%), Gaps = 17/294 (5%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377
F H V V FS ++ LA+G MD + +W + + ++ +G +T + F +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPS 72
Query: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
G L + S D RIW + H+ V S F D V+ S D+T+K+W
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 438 RSKVCIKTVFAGSS-CNDIVCTE-----QCVMSGHFDKKIRFWDIRSESIVRE-MELLGK 490
+ K +F+ S N + C + + ++S DK ++ WD S V E G
Sbjct: 133 HRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550
+T +D +P T + + D+ +KV D+RT+ + Q + + F P G+Y+
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLI 245
Query: 551 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
S++ +L I ++ G++ L H VA+S +G + S + ++W
Sbjct: 246 TASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/246 (20%), Positives = 101/246 (41%), Gaps = 53/246 (21%)
Query: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS----S 451
+D L GH V F ++ ++ SGS D L +W ++ + F G +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVT 65
Query: 452 CNDIVCTEQCVMSGHFDKKIRFW--DIRSES--------IVREMELLGK----ITALD-- 495
C + + + SG DK +R W +++ ES VR + +TA D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 496 ---------------------------LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSA 528
+P+ ++S S D +K+ D + ++
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC- 184
Query: 529 PGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPS 588
+ G T V F P G+ +AA + ++ +W V T ++ + + HS+++N +++ PS
Sbjct: 185 ---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPS 240
Query: 589 GSHVVS 594
G+++++
Sbjct: 241 GNYLIT 246
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 116 bits (290), Expect = 7e-26
Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 16/248 (6%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFDSAG 378
H V +VQFSP LLA+ DR V+LW + G+ EFK A + S++F + G
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH----TAPVRSVDFSADG 114
Query: 379 SYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR 438
+L AS D + ++W++ R ++L H+ V AKF D IVS S D+T+K+WD
Sbjct: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
Query: 439 SKVCIKTVFAGS----SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKITA 493
+K C+ F+ S + D + C+ S D+ ++ WD+R +++ ++ G +
Sbjct: 175 NKQCVNN-FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
Query: 494 LDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGS 553
+ +P L++ S D LK++DL + T G +T V FS G A+G
Sbjct: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG---HTGPVFT-VSFSKGGELFASGG 289
Query: 554 AEGSLYIW 561
A+ + +W
Sbjct: 290 ADTQVLLW 297
Score = 104 bits (259), Expect = 3e-22
Identities = 72/293 (24%), Positives = 130/293 (44%), Gaps = 15/293 (5%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377
F H + ++ SP + LAT D + LW ++ G +TS++F
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYR--YVGHKDVVTSVQFSPH 71
Query: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
G+ L +AS D R+W D H+ V S F D + + S D+++K+W +
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 438 RSKVCIKTVFAGSS---CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREM-ELLGKITA 493
+ + +++ + C + ++S DK I+ WD ++ V + +G
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
Query: 494 LDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS--APGFKCGSDWTRVVFSPDGSYVAA 551
+D NP T + S D +KV D+R N + Q + + G C + F P G+Y+
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC------ISFHPSGNYLIT 245
Query: 552 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
S++G+L I +L G++ L + H+ + V++S G S + +LW
Sbjct: 246 ASSDGTLKILDLLEGRLIYTL-QGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 43.5 bits (101), Expect = 6e-04
Identities = 47/251 (18%), Positives = 93/251 (37%), Gaps = 63/251 (25%)
Query: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDI 455
+D L GH + S + ++ + S D L LW+ + + D+
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHA---RAYRYVGHKDV 62
Query: 456 VCTEQCVMSGHF------DKKIRFW----------------DIRSESIVREMELLGK--- 490
V + Q G+ D+ +R W +RS + + L
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 491 ------------------------ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTF 526
+ +P+ ++SCS D +K+ D F
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Query: 527 S-APGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLS--KQHSSSINAV 583
S + GF V F+P G+ +A+ ++ ++ +W V +V K+L + HS +N +
Sbjct: 183 SDSVGFA-----NFVDFNPSGTCIASAGSDQTVKVWDV---RVNKLLQHYQVHSGGVNCI 234
Query: 584 AWSPSGSHVVS 594
++ PSG+++++
Sbjct: 235 SFHPSGNYLIT 245
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550
IT+LDL+P +L + S D L + + + +A + + G K T V FSP G+ +A
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHA--RAYRYVGHK--DVVTSVQFSPHGNLLA 76
Query: 551 AGSAEGSLYIWSV-LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQY 607
+ S + ++ +W GK + K H++ + +V +S G + + + +W+ Y
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Score = 36.2 bits (82), Expect = 0.090
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 3/56 (5%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 376
H G V V FS G L A+GG D +V LW ++ KG + + + FDS
Sbjct: 269 HTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGL---TKRNLKRLHFDS 321
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 115 bits (288), Expect = 1e-25
Identities = 77/285 (27%), Positives = 143/285 (50%), Gaps = 11/285 (3%)
Query: 316 CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 375
C H V++V+FSP LA+ DR + +W + K ++ +L G N I+ + +
Sbjct: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK--YEKTLYGHNLEISDVAWS 92
Query: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
S S L++AS+D ++W V + TL GHS V F + I+SGS D T+K+W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREM--ELLGK 490
++++ C+KT+ A S S C+ ++SG +D R WD S ++ + +
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP 212
Query: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFS-PDGSYV 549
++ + +P +L+ + D+ LK+ D +T++ G K FS G ++
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT--GHKNEKYCIFANFSVTGGKWI 270
Query: 550 AAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
+GS + +YIW++ T ++ + L + H+ + + A P+ + + S
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVISAACHPTENLIAS 314
Score = 98.6 bits (244), Expect = 1e-20
Identities = 63/244 (25%), Positives = 118/244 (48%), Gaps = 15/244 (6%)
Query: 359 KGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL 418
K +L G ++S++F G +L ++S D IW D + TL GH+ ++ +
Sbjct: 34 KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSS 93
Query: 419 DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS---CNDIVCTEQCVMSGHFDKKIRFWD 475
D++R+VS S D+TLKLWD+RS C+KT+ S+ C + ++SG FD+ ++ W+
Sbjct: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 476 IRSESIVREMEL-LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCG 534
+++ ++ + ++A+ N + ++S S D L ++ D + +T
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDD---N 210
Query: 535 SDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS--------SINAVAWS 586
+ V FSP+G Y+ + + +L +W G+ K + + S+ W
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 587 PSGS 590
SGS
Sbjct: 271 VSGS 274
Score = 80.9 bits (198), Expect = 3e-15
Identities = 56/234 (23%), Positives = 111/234 (47%), Gaps = 8/234 (3%)
Query: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
D+ L++S + + + +Y L+ TL GH+ V S KF + + S S DR + +
Sbjct: 8 DAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIII 67
Query: 435 WDLRSKVCIKTVFAGS-SCNDIVCTEQC--VMSGHFDKKIRFWDIRSESIVREMELLGK- 490
W KT++ + +D+ + ++S DK ++ WD+RS ++ ++
Sbjct: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY 127
Query: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550
+ + NP ++S S D+ +K+ +++T +T SA + V F+ GS +
Sbjct: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSA----VHFNCSGSLIV 183
Query: 551 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
+GS +G IW +G+ K L + ++ V +SP+G ++++ LW
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
Score = 67.4 bits (163), Expect = 4e-11
Identities = 46/171 (26%), Positives = 79/171 (46%), Gaps = 15/171 (8%)
Query: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 374
L AH V+AV F+ L+ +G D ++W+ +C K + N ++ ++F
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC-LKTLVDDDNPPVSFVKF 218
Query: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGK--VLSAKFLLDNAR-IVSGSHDRT 431
G Y+L A+ D ++W R T TGH + + A F + + IVSGS D
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
Query: 432 LKLWDLRSKVCIK------TVFAGSSCNDIVCTEQCVMSGHF--DKKIRFW 474
+ +W+L++K ++ V ++C+ TE + S DK I+ W
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHP---TENLIASAALENDKTIKLW 326
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 111 bits (277), Expect = 2e-24
Identities = 75/280 (26%), Positives = 142/280 (50%), Gaps = 11/280 (3%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSY 380
H V++V+FSP LA+ D+ +K+W + K F+ ++SG GI+ + + S +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 101
Query: 381 LLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK 440
L++AS+D +IW V + TL GHS V F + IVSGS D ++++WD+++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 441 VCIKTVFAGSSCNDIVCTEQ---CVMSGHFDKKIRFWDIRSESIVREM--ELLGKITALD 495
C+KT+ A S V + ++S +D R WD S ++ + + ++ +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 496 LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFS-PDGSYVAAGSA 554
+P +L+ + D+ LK+ D +T++ G K FS G ++ +GS
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYT--GHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 555 EGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
+ +YIW++ T ++ + L + H+ + + A P+ + + S
Sbjct: 280 DNLVYIWNLQTKEIVQKL-QGHTDVVISTACHPTENIIAS 318
Score = 101 bits (251), Expect = 2e-21
Identities = 63/244 (25%), Positives = 118/244 (48%), Gaps = 15/244 (6%)
Query: 359 KGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL 418
K +L+G ++S++F G +L ++S D +IW D + T++GH + +
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 419 DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS---CNDIVCTEQCVMSGHFDKKIRFWD 475
D+ +VS S D+TLK+WD+ S C+KT+ S+ C + ++SG FD+ +R WD
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 476 IRSESIVREMEL-LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCG 534
+++ ++ + ++A+ N + + ++S S D L ++ D + +T
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD---N 214
Query: 535 SDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS--------SINAVAWS 586
+ V FSP+G Y+ A + + +L +W GK K + + S+ W
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 587 PSGS 590
SGS
Sbjct: 275 VSGS 278
Score = 77.0 bits (188), Expect = 5e-14
Identities = 51/212 (24%), Positives = 100/212 (47%), Gaps = 8/212 (3%)
Query: 397 DYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS-SCNDI 455
+Y L+ TL GH+ V S KF + + S S D+ +K+W KT+ +D+
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 456 VCTEQC--VMSGHFDKKIRFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLL 512
+ ++S DK ++ WD+ S ++ ++ + + NP+ ++S S D+ +
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 513 KVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVL 572
++ D++T +T A + V F+ DGS + + S +G IW +G+ K L
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSA----VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 573 SKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
+ ++ V +SP+G ++++ LW
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 68.2 bits (165), Expect = 2e-11
Identities = 50/196 (25%), Positives = 87/196 (44%), Gaps = 19/196 (9%)
Query: 294 PQDNVDTHPGSGKEVRV----PATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW 349
PQ N+ + VR+ L AH V+AV F+ L+ + D ++W
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 350 EVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSG 409
+ +C K + N ++ ++F G Y+LAA+ D ++W + T TGH
Sbjct: 199 DTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 410 K--VLSAKFLLDNAR-IVSGSHDRTLKLWDLRSKVCIK------TVFAGSSCNDIVCTEQ 460
+ + A F + + IVSGS D + +W+L++K ++ V ++C+ TE
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP---TEN 314
Query: 461 CVMSGHF--DKKIRFW 474
+ S DK I+ W
Sbjct: 315 IIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 111 bits (277), Expect = 2e-24
Identities = 75/280 (26%), Positives = 142/280 (50%), Gaps = 11/280 (3%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSY 380
H V++V+FSP LA+ D+ +K+W + K F+ ++SG GI+ + + S +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 101
Query: 381 LLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK 440
L++AS+D +IW V + TL GHS V F + IVSGS D ++++WD+++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 441 VCIKTVFAGSSCNDIVCTEQ---CVMSGHFDKKIRFWDIRSESIVREM--ELLGKITALD 495
C+KT+ A S V + ++S +D R WD S ++ + + ++ +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 496 LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFS-PDGSYVAAGSA 554
+P +L+ + D+ LK+ D +T++ G K FS G ++ +GS
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYT--GHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 555 EGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
+ +YIW++ T ++ + L + H+ + + A P+ + + S
Sbjct: 280 DNLVYIWNLQTKEIVQKL-QGHTDVVISTACHPTENIIAS 318
Score = 101 bits (251), Expect = 2e-21
Identities = 63/244 (25%), Positives = 118/244 (48%), Gaps = 15/244 (6%)
Query: 359 KGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL 418
K +L+G ++S++F G +L ++S D +IW D + T++GH + +
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 419 DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS---CNDIVCTEQCVMSGHFDKKIRFWD 475
D+ +VS S D+TLK+WD+ S C+KT+ S+ C + ++SG FD+ +R WD
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 476 IRSESIVREMEL-LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCG 534
+++ ++ + ++A+ N + + ++S S D L ++ D + +T
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD---N 214
Query: 535 SDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS--------SINAVAWS 586
+ V FSP+G Y+ A + + +L +W GK K + + S+ W
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 587 PSGS 590
SGS
Sbjct: 275 VSGS 278
Score = 77.0 bits (188), Expect = 5e-14
Identities = 51/212 (24%), Positives = 100/212 (47%), Gaps = 8/212 (3%)
Query: 397 DYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS-SCNDI 455
+Y L+ TL GH+ V S KF + + S S D+ +K+W KT+ +D+
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 456 VCTEQC--VMSGHFDKKIRFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLL 512
+ ++S DK ++ WD+ S ++ ++ + + NP+ ++S S D+ +
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 513 KVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVL 572
++ D++T +T A + V F+ DGS + + S +G IW +G+ K L
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSA----VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 573 SKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
+ ++ V +SP+G ++++ LW
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 68.2 bits (165), Expect = 2e-11
Identities = 50/196 (25%), Positives = 87/196 (44%), Gaps = 19/196 (9%)
Query: 294 PQDNVDTHPGSGKEVRV----PATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW 349
PQ N+ + VR+ L AH V+AV F+ L+ + D ++W
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 350 EVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSG 409
+ +C K + N ++ ++F G Y+LAA+ D ++W + T TGH
Sbjct: 199 DTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 410 K--VLSAKFLLDNAR-IVSGSHDRTLKLWDLRSKVCIK------TVFAGSSCNDIVCTEQ 460
+ + A F + + IVSGS D + +W+L++K ++ V ++C+ TE
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP---TEN 314
Query: 461 CVMSGHF--DKKIRFW 474
+ S DK I+ W
Sbjct: 315 IIASAALENDKTIKLW 330
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 107 bits (266), Expect = 4e-23
Identities = 73/253 (28%), Positives = 119/253 (47%), Gaps = 20/253 (7%)
Query: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377
F H E+ + F+P S L+ATG MD KLW++ + E +L G +A I S+ F+++
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI--QNGEEVYTLRGHSAEIISLSFNTS 230
Query: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
G ++ S D +W D R + L GH ++ SA F D + I++GS D+T KLWD
Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDA 290
Query: 438 RSKVCIKTVFAG-----SSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKI 491
+ C+ T+ SC D T + + + D R + + + ++E G+I
Sbjct: 291 TNGKCVATLTGHDDEILDSCFDY--TGKLIATASADGTARIFSAATRKCIAKLEGHEGEI 348
Query: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG---FKCGSDWTRVVFSPDGSY 548
+ + NP+ LL+ S D ++ D +T Q F C F+ G+
Sbjct: 349 SKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC-------AFNYKGNI 401
Query: 549 VAAGSAEGSLYIW 561
V GS + + IW
Sbjct: 402 VITGSKDNTCRIW 414
Score = 84.0 bits (206), Expect = 4e-16
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 20/297 (6%)
Query: 317 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 376
V AH + V + TG DR KLW+ E +L G + +I F++
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAFNN 144
Query: 377 A-GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
G + S D ++W+V+ + HT GH+ +++ F + + +GS D T KLW
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 436 DLRSKVCIKTVFAGSSCNDIVCTEQC----VMSGHFDKKIRFWDIRSESIVREMELL--- 488
D+++ + T+ G S I + +++G FD + WD + R++ +L
Sbjct: 205 DIQNGEEVYTL-RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG---RKVNILIGH 260
Query: 489 -GKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 547
+I++ N + + +L+ S D K+ D T + + F G
Sbjct: 261 CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGH----DDEILDSCFDYTGK 316
Query: 548 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
+A SA+G+ I+S T K L + H I+ ++++P G+H+++ A +W
Sbjct: 317 LIATASADGTARIFSAATRKCIAKL-EGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 94.4 bits (233), Expect = 3e-19
Identities = 60/222 (27%), Positives = 106/222 (47%), Gaps = 30/222 (13%)
Query: 287 SVSSFPVPQD--NVDTHPGSGKEV-RVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMD 343
+V +P+P+ + +T P +G + + T C HD ++N+V +P +LLATG D
Sbjct: 445 TVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC----HDKDINSVAIAPNDKLLATGSQD 500
Query: 344 RRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHT 403
R KLW + +C+ G SG G+ ++F L AS D ++W + D+ T
Sbjct: 501 RTAKLWAL--PQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFA------GSSCNDIVC 457
GH VL F+ +++S D +KLW +++ C++T+ A G C+ +
Sbjct: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL-- 616
Query: 458 TEQCVMSGHFDKKIRFW-DI-----------RSESIVREMEL 487
+ ++G D ++ W D+ + E +VR+ EL
Sbjct: 617 -DDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQEL 657
Score = 63.5 bits (153), Expect = 5e-10
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEV---FGEKCEFKGSLSGSNAGITSIEFDSA 377
H V + F P S LLATGG D V++W++ +G F+GS + + + D
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTH-HFRGSPGVVH--LVAFHPDPT 164
Query: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
L +++ D A R+W++ D LT H V S F D ++S D+ +WDL
Sbjct: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
Query: 438 RSKVCIKTV 446
+S +TV
Sbjct: 225 QSCQATRTV 233
Score = 44.3 bits (103), Expect = 3e-04
Identities = 64/302 (21%), Positives = 120/302 (39%), Gaps = 36/302 (11%)
Query: 331 SPGSRLLATGGMDRRVKLWEVFGEKCEF-KGSLSGSNAGITSIEFDSAGSYLLAASNDFA 389
SPG L T G +++WE +C + + G +T +L A+ D
Sbjct: 257 SPGLYFL-TAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHN 315
Query: 390 SRIWTVDDYRLRHTLTGHSGKVLSAKFL-LDNARIVSGSHDRTLKLWDLRSKVCIKTVFA 448
++ RL+ G+S +VL +FL +++ +V S+ LK+++L++ C +
Sbjct: 316 LLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC--QILH 373
Query: 449 GSSCNDIVCTEQCVMSGHF------DKKIRFWDIRSESIVR-------EMELLGKITALD 495
G + DIV G D+ +R W + V +G +
Sbjct: 374 GHT--DIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR 431
Query: 496 LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG-----------FKC-GSDWTRVVFS 543
L + + L++ S+D +K+ L A+ +AP +C D V +
Sbjct: 432 L--KESFLVTGSQDCTVKLWPL-PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIA 488
Query: 544 PDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVL 603
P+ +A GS + + +W++ ++ V S H + V +SP + + L
Sbjct: 489 PNDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRGLWCVQFSPMDQVLATASADGTIKL 547
Query: 604 WA 605
WA
Sbjct: 548 WA 549
Score = 35.8 bits (81), Expect = 0.12
Identities = 34/155 (21%), Positives = 67/155 (43%), Gaps = 22/155 (14%)
Query: 470 KIRFWDIRSESIVREMELLGK--ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS 527
++ ++ S +++R +E + ITA DL+P+ L++ SR LL + ++ + +
Sbjct: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
Query: 528 APGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVL-----------TGKVEKVLSKQH 576
A + + F P + +A G +G++ +W ++ G V V H
Sbjct: 106 AIHT---APVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAF--H 160
Query: 577 SSSINAVAWSPSGSHVVSV----DKGCKAVLWAQY 607
+ +S + + V D+ C AVL A Y
Sbjct: 161 PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHY 195
Score = 34.3 bits (77), Expect = 0.34
Identities = 65/308 (21%), Positives = 117/308 (37%), Gaps = 60/308 (19%)
Query: 313 TALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE----------FKGSL 362
+ L V AH V ++ FS + + G D+ +W++ + C+ + ++
Sbjct: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL--QSCQATRTVPVFESVEAAV 243
Query: 363 SGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLT--GHSGKVLSAKFLLDN 420
++ + S G Y L A + R+W + +T G+ L+ L
Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 421 ARIV-SGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSE 479
A +V + + D L L++ RS + ++ FAG S E+ + +RF
Sbjct: 304 AGVVLTATADHNLLLYEARS-LRLQKQFAGYS-------EEVL-------DVRF------ 342
Query: 480 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTR 539
L PE + ++ S LKV +L+T+A + D R
Sbjct: 343 ----------------LGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFR 386
Query: 540 VVFSPDGSYVAAGSAEGSLYIWSV-LTGKVEKVL-SKQHSSSINAVAWSP-SGSHVVSVD 596
G A+ + + S+ IW + G+V V H+ S+ V S S +V+
Sbjct: 387 -----KGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGS 441
Query: 597 KGCKAVLW 604
+ C LW
Sbjct: 442 QDCTVKLW 449
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 90.1 bits (222), Expect = 5e-18
Identities = 68/250 (27%), Positives = 114/250 (45%), Gaps = 16/250 (6%)
Query: 320 AHDGEVNAVQFSPGS-RLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAG 378
AH V+++ S RLLATGG D RV LW + C SL+G + + S+ ++
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESVRLNTPE 75
Query: 379 SYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR 438
++A S + R+W ++ ++ TL GH + S F + SGS D +KLWD+R
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 439 SKVCIKTVFAGSS----CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITA 493
K C+ + G S C + + S D ++ WD+ + ++ E G +
Sbjct: 136 RKGCVFR-YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
Query: 494 LDLNPERTELLSCSRDDLLKVIDL-RTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAG 552
++ +P L S S D ++ DL + + PG V+F+PDG + +G
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG-----PVRSVLFNPDGCCLYSG 249
Query: 553 SAEG-SLYIW 561
+ +Y W
Sbjct: 250 CQDSLRVYGW 259
Score = 57.8 bits (138), Expect = 3e-08
Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 10/190 (5%)
Query: 404 LTGHSGKVLSAKFLLDNARIVS-GSHDRTLKLWDLRSKVCIKTVFAGSSCNDIV---CTE 459
+ H+ V S + R+++ G D + LW + CI ++ +S + V E
Sbjct: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
Query: 460 QCVMSGHFDKKIRFWDIRSESIVRE-MELLGKITALDLNPERTELLSCSRDDLLKVIDLR 518
+ +++G IR WD+ + I+R M I +LD +P + S S+D +K+ D+R
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 519 TNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS 578
F G R FSPDG ++A+ + + ++ +W + GK+ H+
Sbjct: 136 RKGC--VFRYRGHSQAVRCLR--FSPDGKWLASAADDHTVKLWDLTAGKMMSEF-PGHTG 190
Query: 579 SINAVAWSPS 588
+N V + P+
Sbjct: 191 PVNVVEFHPN 200
Score = 57.4 bits (137), Expect = 4e-08
Identities = 39/151 (25%), Positives = 65/151 (43%), Gaps = 7/151 (4%)
Query: 316 CVFD--AHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIE 373
CVF H V ++FSP + LA+ D VKLW++ K G + +E
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK--MMSEFPGHTGPVNVVE 196
Query: 374 FDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLK 433
F L + S+D R W ++ +++ + G G V S F D + SG D +L+
Sbjct: 197 FHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLR 255
Query: 434 LWDLRSKVCIKTVFA--GSSCNDIVCTEQCV 462
++ + C V G + +C +Q +
Sbjct: 256 VYGWEPERCFDVVLVNWGKVADLAICNDQLI 286
Score = 40.4 bits (93), Expect = 0.005
Identities = 37/148 (25%), Positives = 66/148 (44%), Gaps = 18/148 (12%)
Query: 464 SGHFDKKIRFWDIRSESIVREMELLGKITALD---LNPERTELLSCSRDDLLKVIDLRTN 520
+G D ++ W I + + M L G + ++ LN +++ S+ ++V DL
Sbjct: 38 TGGDDCRVNLWSINKPNCI--MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 521 AIKQTFSAPGFK---CGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLT-GKVEKVLSKQH 576
I +T G K C D F P G +VA+GS + ++ +W + G V + + H
Sbjct: 96 KILRTLM--GHKANICSLD-----FHPYGEFVASGSQDTNIKLWDIRRKGCVFRY--RGH 146
Query: 577 SSSINAVAWSPSGSHVVSVDKGCKAVLW 604
S ++ + +SP G + S LW
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLW 174
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/307 (23%), Positives = 130/307 (42%), Gaps = 35/307 (11%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSY 380
H V V F P ++ + D +K+W+ E +F+ +L G + I FD +G
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDY--ETGDFERTLKGHTDSVQDISFDHSGKL 164
Query: 381 LLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK 440
L + S D ++W + T+ GH V S + + IVS S D+T+K+W++++
Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTG 224
Query: 441 VCIKTVFAGSSCNDIVCTEQ---CVMSGHFDKKIRFWDIRSESIVREM-ELLGKITALDL 496
C+KT +V Q + S D+ +R W + ++ E+ E + +
Sbjct: 225 YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISW 284
Query: 497 NPERTE--------------------LLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSD 536
PE + LLS SRD +K+ D+ T T +
Sbjct: 285 APESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG-----HDN 339
Query: 537 WTR-VVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVV-- 593
W R V+F G ++ + + + +L +W + K L+ H + ++ + + +VV
Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN-AHEHFVTSLDFHKTAPYVVTG 398
Query: 594 SVDKGCK 600
SVD+ K
Sbjct: 399 SVDQTVK 405
Score = 77.4 bits (189), Expect = 4e-14
Identities = 55/234 (23%), Positives = 103/234 (44%), Gaps = 45/234 (19%)
Query: 359 KGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL 418
K +LSG + +T + F S +++AS D ++W + TL GH+ V F
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 419 DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRS 478
+ S S D T+KLWD + CI+T M GH
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRT-----------------MHGHDH---------- 193
Query: 479 ESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
++++ + P ++S SRD +K+ +++T +TF+ +W
Sbjct: 194 -----------NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTG-----HREWV 237
Query: 539 RVVF-SPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSH 591
R+V + DG+ +A+ S + ++ +W V T + + L ++H + ++W+P S+
Sbjct: 238 RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL-REHEHVVECISWAPESSY 290
Score = 62.8 bits (151), Expect = 9e-10
Identities = 49/188 (26%), Positives = 80/188 (42%), Gaps = 23/188 (12%)
Query: 313 TALCV--FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKC-------------- 356
T CV F H V V+ + L+A+ D+ V++W V ++C
Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
Query: 357 ----EFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVL 412
E S G + + G +LL+ S D ++W V TL GH V
Sbjct: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
Query: 413 SAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDK 469
F I+S + D+TL++WD ++K C+KT+ A + D T V++G D+
Sbjct: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
Query: 470 KIRFWDIR 477
++ W+ R
Sbjct: 403 TVKVWECR 410
Score = 39.3 bits (90), Expect = 0.011
Identities = 27/115 (23%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTR-VVFSPDGSYV 549
+T + +P + ++S S D +KV D T ++T K +D + + F G +
Sbjct: 111 VTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL-----KGHTDSVQDISFDHSGKLL 165
Query: 550 AAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
A+ SA+ ++ +W + + + H ++++VA P+G H+VS + +W
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHG-HDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 88.6 bits (218), Expect = 2e-17
Identities = 63/238 (26%), Positives = 117/238 (49%), Gaps = 13/238 (5%)
Query: 330 FSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFA 389
F P LAT D VKLW++ C + G + + S + S G+++ ++S D
Sbjct: 402 FHPSGDKLATSSGDTTVKLWDLCKGDCIL--TFEGHSRAVWSCTWHSCGNFVASSSLDKT 459
Query: 390 SRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAG 449
S+IW V+ R R TL GH+ V S +F + +++ S D+TL +WD R+ +C ++++
Sbjct: 460 SKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGH 519
Query: 450 -SSCNDIVCTEQCVMSGHFDK--KIRFWDIRSESIVREMELLGKITALDLNPERT--ELL 504
S ND + + M D + WD R + ++ +G ++N + + L
Sbjct: 520 MHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSID-IGPSPGNEVNFDSSGRVLA 578
Query: 505 SCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWS 562
S + ++ ++DL++ I + ++ VVFS DG + +G ++G++ WS
Sbjct: 579 QASGNGVIHLLDLKSGEIHKLMGHE-----NEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 58.5 bits (140), Expect = 2e-08
Identities = 71/292 (24%), Positives = 103/292 (35%), Gaps = 61/292 (20%)
Query: 280 TNIFGRRSVSSFPV---PQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRL 336
T + G S FP+ P N++ S + +F H+ V+ V P +
Sbjct: 307 TKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDI 366
Query: 337 LATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVD 396
L + G DR LW+V G L N +T
Sbjct: 367 LVSCGEDR---LWKVLG--------LPKCNVLLTGF------------------------ 391
Query: 397 DYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIV 456
GH+ + F ++ + S D T+KLWDL CI T F G S
Sbjct: 392 ---------GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILT-FEGHSRAVWS 441
Query: 457 CT-EQC---VMSGHFDKKIRFWDIRSESIVREMELLG---KITALDLNPERTELLSCSRD 509
CT C V S DK + WD+ SE L G + +++ P LL+ S D
Sbjct: 442 CTWHSCGNFVASSSLDKTSKIWDVNSERC--RCTLYGHTDSVNSIEFFPFSNTLLTSSAD 499
Query: 510 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIW 561
L + D RT +Q+ +F P G +A+ A G +W
Sbjct: 500 KTLSIWDARTGICEQSLYGHMHSIND----AIFDPRGHMIASCDACGVTKLW 547
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 13/134 (9%)
Query: 474 WDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDL-RTNAIKQTFSAPGFK 532
+D + ++I R EL ++ + + P + L+SC D L KV+ L + N + F
Sbjct: 340 FDYKLKNIFRLHEL--PVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFG----- 392
Query: 533 CGSDW-TRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLS-KQHSSSINAVAWSPSGS 590
+DW + F P G +A S + ++ +W + G + +L+ + HS ++ + W G+
Sbjct: 393 -HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG--DCILTFEGHSRAVWSCTWHSCGN 449
Query: 591 HVVSVDKGCKAVLW 604
V S + +W
Sbjct: 450 FVASSSLDKTSKIW 463
Score = 41.2 bits (95), Expect = 0.003
Identities = 37/163 (22%), Positives = 67/163 (41%), Gaps = 8/163 (4%)
Query: 316 CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 375
C H VN+++F P S L T D+ + +W+ CE SL G I FD
Sbjct: 472 CTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE--QSLYGHMHSINDAIFD 529
Query: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNAR--IVSGSHDRTLK 433
G + + +++W D +L ++ G + D++ + S + +
Sbjct: 530 PRGHMIASCDACGVTKLW--DFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIH 587
Query: 434 LWDLRSKVCIKTVFAGSSCNDIVCTE--QCVMSGHFDKKIRFW 474
L DL+S K + + + +V + + + SG D +R W
Sbjct: 588 LLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 87.8 bits (216), Expect = 3e-17
Identities = 79/297 (26%), Positives = 124/297 (41%), Gaps = 21/297 (7%)
Query: 310 VPATALC----VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGS 365
VPAT F H GEVN+ FSP ++L TG D V WE + ++ L G
Sbjct: 5 VPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGH 62
Query: 366 NAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVS 425
+ F G +AS D R+W V + L GH V + F D+ ++ S
Sbjct: 63 TGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS 122
Query: 426 GSHDRTLKLWDLRSKVCIKTVFA---GSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIV 482
G D+ + LWD++S ++ + +D T C+ +G +D + WD+R +
Sbjct: 123 GGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPA 182
Query: 483 REMELLGKITALDLNPERTELLSCSRDDLLK--VIDLRTNAIKQTFSA--PGFKCGSDWT 538
+ AL+ + L S LL D + K T S+ K W
Sbjct: 183 VSHQ------ALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWV 236
Query: 539 R-VVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
+ + FSPD ++A+ + +W TGK + L K + A++P G +VS
Sbjct: 237 KSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL-KGVLDVAHTCAFTPDGKILVS 292
Score = 68.2 bits (165), Expect = 2e-11
Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 12/248 (4%)
Query: 364 GSNAG-ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNAR 422
G + G + S F G LL S D W +L L GH+G V +F D
Sbjct: 18 GQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHL 77
Query: 423 IVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVC---TEQCVMSGHFDKKIRFWDIRSE 479
S S D T++LWD+ C++ + + V + + SG +DK++ WD++S
Sbjct: 78 FASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 480 SIVREMELLG---KITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSD 536
++R L+G I + D +P L + S D + + DLR + S + S
Sbjct: 138 QMLR--LLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR--MVTPAVSHQALEGHSA 193
Query: 537 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVD 596
+ +A+GS + +++IW T + + K H + + ++A+SP + S
Sbjct: 194 NISCLCYSASGLLASGSWDKTIHIWKPTTSSL-LIQLKGHVTWVKSIAFSPDELWLASAG 252
Query: 597 KGCKAVLW 604
+W
Sbjct: 253 YSRMVKVW 260
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 3/130 (2%)
Query: 311 PATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGIT 370
PA + + H ++ + +S S LLA+G D+ + +W+ + L G +
Sbjct: 181 PAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIHIWKPTTSSLLIQ--LKGHVTWVK 237
Query: 371 SIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDR 430
SI F +L +A ++W + + TL G + F D +VSG+ D+
Sbjct: 238 SIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
Query: 431 TLKLWDLRSK 440
T + SK
Sbjct: 298 TRRQISRTSK 307
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 87.4 bits (215), Expect = 3e-17
Identities = 71/284 (25%), Positives = 128/284 (45%), Gaps = 37/284 (13%)
Query: 322 DGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYL 381
D V + FS + +LATG D ++K+W++ +C + + S G+T + F S +
Sbjct: 264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSK-GVTCLSFSKDSSQI 322
Query: 382 LAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKV 441
L+AS D RI + + GHS V A F D I+S S D T+K+W++++
Sbjct: 323 LSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
Query: 442 CIKTVFA-GSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPER 500
C T + GS+ DI S++ L NPE
Sbjct: 383 CSNTFKSLGSTAGT--------------------DITVNSVI----------LLPKNPEH 412
Query: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYI 560
+ C+R + + +++++ ++ +FS+ G + G D+ SP G ++ + LY
Sbjct: 413 --FVVCNRSNTVVIMNMQGQIVR-SFSS-GKREGGDFVCCALSPRGEWIYCVGEDFVLYC 468
Query: 561 WSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
+S +TGK+E+ L+ H + +A P + + + + LW
Sbjct: 469 FSTVTGKLERTLT-VHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 58.5 bits (140), Expect = 2e-08
Identities = 73/320 (22%), Positives = 132/320 (41%), Gaps = 49/320 (15%)
Query: 303 GSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSL 362
GS KE R A A A GEV+ V P SRL+A G + W+ + +G L
Sbjct: 135 GSSKEKRRAAIA----QALAGEVSVV---PPSRLMALLGQALK---WQ------QHQGLL 178
Query: 363 SGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNAR 422
G+T F + F +++ RH G V A+F D
Sbjct: 179 P---PGMTIDLFRGKAAVKDVEEEKFPTQL-------SRHIKFGQKSHVECARFSPDGQY 228
Query: 423 IVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE-----------QCVMSGHFDKKI 471
+V+GS D +++W+ + K + + N ++ + + + +G D KI
Sbjct: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
Query: 472 RFWDIRSESIVREMELLGK--ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAP 529
+ W I+S +R E +T L + + +++LS S D +++ L++ + F
Sbjct: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGH 348
Query: 530 GFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS-----SINAVA 584
S F+ DG Y+ + S++G++ IW++ T + S+ ++N+V
Sbjct: 349 ----SSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVI 404
Query: 585 WSPSG-SHVVSVDKGCKAVL 603
P H V ++ V+
Sbjct: 405 LLPKNPEHFVVCNRSNTVVI 424
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 86.3 bits (212), Expect = 8e-17
Identities = 88/366 (24%), Positives = 145/366 (39%), Gaps = 78/366 (21%)
Query: 307 EVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW-----------EVFGEK 355
EV +P++ V H+ EV ++P S LLA+G D ++W ++
Sbjct: 166 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 225
Query: 356 CEFKGSLS-GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
C +G SN +TS+++++ G+ L S D +RIWT +D L TL H G + +
Sbjct: 226 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFAL 284
Query: 415 KFLLDNARIVSGSHDRTLKLWDLRSKVCIK-----------------TVFAGSSCNDIVC 457
K+ I+S D+T +WD + + T FA SC+ +C
Sbjct: 285 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA--SCSTDMC 342
Query: 458 TEQC---------VMSGHF--------------------DKKIRFWDIRSESIVREMELL 488
C GH D ++ W ++ E + +++
Sbjct: 343 IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAH 402
Query: 489 GK-ITALDLNP---------ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
K I + +P L S S D +++ D+ T + K
Sbjct: 403 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT----KHQEPVY 458
Query: 539 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHV-VSVDK 597
V FSPDG Y+A+GS + ++IW+ +G + V S + + I V W+ G V S
Sbjct: 459 SVAFSPDGKYLASGSFDKCVHIWNTQSGNL--VHSYRGTGGIFEVCWNARGDKVGASASD 516
Query: 598 GCKAVL 603
G VL
Sbjct: 517 GSVCVL 522
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/170 (24%), Positives = 76/170 (44%), Gaps = 12/170 (7%)
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL-- 418
+ G + +I++D +G L + S+D +IW++ H L H+ ++ + K+
Sbjct: 356 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 415
Query: 419 -------DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFD 468
N + S S D T++LWD+ VC T+ V + + SG FD
Sbjct: 416 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 475
Query: 469 KKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLR 518
K + W+ +S ++V G I + N ++ + + D + V+DLR
Sbjct: 476 KCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/222 (22%), Positives = 83/222 (37%), Gaps = 29/222 (13%)
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-----------KVCIKTVFAGSSC 452
L GH +V + + + SGS D T ++W+L + CI+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 453 NDIVCTEQ------CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSC 506
N V + + +G +D R W + G I AL N + +LS
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 296
Query: 507 SRDDLLKVIDLRTNAIKQTF---SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSV 563
D + D T KQ F SAP DW + + A+ S + +++ +
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPFHSAPALDV--DWQ------NNTTFASCSTDMCIHVCRL 348
Query: 564 LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWA 605
+ K + H++ +NA+ W PSG + S +W+
Sbjct: 349 GCDRPVKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 389
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 86.3 bits (212), Expect = 8e-17
Identities = 88/366 (24%), Positives = 145/366 (39%), Gaps = 78/366 (21%)
Query: 307 EVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW-----------EVFGEK 355
EV +P++ V H+ EV ++P S LLA+G D ++W ++
Sbjct: 166 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 225
Query: 356 CEFKGSLS-GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
C +G SN +TS+++++ G+ L S D +RIWT +D L TL H G + +
Sbjct: 226 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFAL 284
Query: 415 KFLLDNARIVSGSHDRTLKLWDLRSKVCIK-----------------TVFAGSSCNDIVC 457
K+ I+S D+T +WD + + T FA SC+ +C
Sbjct: 285 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA--SCSTDMC 342
Query: 458 TEQC---------VMSGHF--------------------DKKIRFWDIRSESIVREMELL 488
C GH D ++ W ++ E + +++
Sbjct: 343 IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAH 402
Query: 489 GK-ITALDLNP---------ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
K I + +P L S S D +++ D+ T + K
Sbjct: 403 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT----KHQEPVY 458
Query: 539 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHV-VSVDK 597
V FSPDG Y+A+GS + ++IW+ +G + V S + + I V W+ G V S
Sbjct: 459 SVAFSPDGKYLASGSFDKCVHIWNTQSGNL--VHSYRGTGGIFEVCWNARGDKVGASASD 516
Query: 598 GCKAVL 603
G VL
Sbjct: 517 GSVCVL 522
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/170 (24%), Positives = 76/170 (44%), Gaps = 12/170 (7%)
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL-- 418
+ G + +I++D +G L + S+D +IW++ H L H+ ++ + K+
Sbjct: 356 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 415
Query: 419 -------DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFD 468
N + S S D T++LWD+ VC T+ V + + SG FD
Sbjct: 416 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 475
Query: 469 KKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLR 518
K + W+ +S ++V G I + N ++ + + D + V+DLR
Sbjct: 476 KCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/222 (22%), Positives = 83/222 (37%), Gaps = 29/222 (13%)
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-----------KVCIKTVFAGSSC 452
L GH +V + + + SGS D T ++W+L + CI+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 453 NDIVCTEQ------CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSC 506
N V + + +G +D R W + G I AL N + +LS
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 296
Query: 507 SRDDLLKVIDLRTNAIKQTF---SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSV 563
D + D T KQ F SAP DW + + A+ S + +++ +
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPFHSAPALDV--DWQ------NNTTFASCSTDMCIHVCRL 348
Query: 564 LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWA 605
+ K + H++ +NA+ W PSG + S +W+
Sbjct: 349 GCDRPVKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 389
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 86.3 bits (212), Expect = 8e-17
Identities = 88/366 (24%), Positives = 145/366 (39%), Gaps = 78/366 (21%)
Query: 307 EVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW-----------EVFGEK 355
EV +P++ V H+ EV ++P S LLA+G D ++W ++
Sbjct: 217 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 276
Query: 356 CEFKGSLS-GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
C +G SN +TS+++++ G+ L S D +RIWT +D L TL H G + +
Sbjct: 277 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFAL 335
Query: 415 KFLLDNARIVSGSHDRTLKLWDLRSKVCIK-----------------TVFAGSSCNDIVC 457
K+ I+S D+T +WD + + T FA SC+ +C
Sbjct: 336 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA--SCSTDMC 393
Query: 458 TEQC---------VMSGHF--------------------DKKIRFWDIRSESIVREMELL 488
C GH D ++ W ++ E + +++
Sbjct: 394 IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAH 453
Query: 489 GK-ITALDLNP---------ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
K I + +P L S S D +++ D+ T + K
Sbjct: 454 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT----KHQEPVY 509
Query: 539 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHV-VSVDK 597
V FSPDG Y+A+GS + ++IW+ +G + V S + + I V W+ G V S
Sbjct: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNL--VHSYRGTGGIFEVCWNARGDKVGASASD 567
Query: 598 GCKAVL 603
G VL
Sbjct: 568 GSVCVL 573
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/170 (24%), Positives = 76/170 (44%), Gaps = 12/170 (7%)
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL-- 418
+ G + +I++D +G L + S+D +IW++ H L H+ ++ + K+
Sbjct: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
Query: 419 -------DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFD 468
N + S S D T++LWD+ VC T+ V + + SG FD
Sbjct: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
Query: 469 KKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLR 518
K + W+ +S ++V G I + N ++ + + D + V+DLR
Sbjct: 527 KCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/222 (22%), Positives = 83/222 (37%), Gaps = 29/222 (13%)
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-----------KVCIKTVFAGSSC 452
L GH +V + + + SGS D T ++W+L + CI+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 453 NDIVCTEQ------CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSC 506
N V + + +G +D R W + G I AL N + +LS
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
Query: 507 SRDDLLKVIDLRTNAIKQTF---SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSV 563
D + D T KQ F SAP DW + + A+ S + +++ +
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDV--DWQ------NNTTFASCSTDMCIHVCRL 399
Query: 564 LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWA 605
+ K + H++ +NA+ W PSG + S +W+
Sbjct: 400 GCDRPVKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 440
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 86.3 bits (212), Expect = 8e-17
Identities = 88/366 (24%), Positives = 145/366 (39%), Gaps = 78/366 (21%)
Query: 307 EVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW-----------EVFGEK 355
EV +P++ V H+ EV ++P S LLA+G D ++W ++
Sbjct: 217 EVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 276
Query: 356 CEFKGSLS-GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
C +G SN +TS+++++ G+ L S D +RIWT +D L TL H G + +
Sbjct: 277 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFAL 335
Query: 415 KFLLDNARIVSGSHDRTLKLWDLRSKVCIK-----------------TVFAGSSCNDIVC 457
K+ I+S D+T +WD + + T FA SC+ +C
Sbjct: 336 KWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA--SCSTDMC 393
Query: 458 TEQC---------VMSGHF--------------------DKKIRFWDIRSESIVREMELL 488
C GH D ++ W ++ E + +++
Sbjct: 394 IHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAH 453
Query: 489 GK-ITALDLNP---------ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
K I + +P L S S D +++ D+ T + K
Sbjct: 454 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT----KHQEPVY 509
Query: 539 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHV-VSVDK 597
V FSPDG Y+A+GS + ++IW+ +G + V S + + I V W+ G V S
Sbjct: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNL--VHSYRGTGGIFEVCWNARGDKVGASASD 567
Query: 598 GCKAVL 603
G VL
Sbjct: 568 GSVCVL 573
Score = 59.7 bits (143), Expect = 8e-09
Identities = 41/170 (24%), Positives = 76/170 (44%), Gaps = 12/170 (7%)
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL-- 418
+ G + +I++D +G L + S+D +IW++ H L H+ ++ + K+
Sbjct: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
Query: 419 -------DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFD 468
N + S S D T++LWD+ VC T+ V + + SG FD
Sbjct: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
Query: 469 KKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLR 518
K + W+ +S ++V G I + N ++ + + D + V+DLR
Sbjct: 527 KCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/222 (22%), Positives = 83/222 (37%), Gaps = 29/222 (13%)
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-----------KVCIKTVFAGSSC 452
L GH +V + + + SGS D T ++W+L + CI+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 453 NDIVCTEQ------CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSC 506
N V + + +G +D R W + G I AL N + +LS
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
Query: 507 SRDDLLKVIDLRTNAIKQTF---SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSV 563
D + D T KQ F SAP DW + + A+ S + +++ +
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDV--DWQ------NNTTFASCSTDMCIHVCRL 399
Query: 564 LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWA 605
+ K + H++ +NA+ W PSG + S +W+
Sbjct: 400 GCDRPVKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 440
>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
Length = 919
Score = 85.9 bits (211), Expect = 1e-16
Identities = 126/546 (23%), Positives = 217/546 (39%), Gaps = 87/546 (15%)
Query: 64 PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122
P + E + D T Q QE + R+++Q+ L + ++R Q++++ NQ D+
Sbjct: 411 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 467
Query: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
+ + E + +Q KL +L L +E AL +G
Sbjct: 468 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 510
Query: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
N VT + + RL +A N S R + + P + +
Sbjct: 511 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 568
Query: 241 EVIVDETSDHT------------------------EETSPVRAISRAATKRLSQPAGGLL 276
VI D E+T VRA++ PAGGL
Sbjct: 569 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVA-------FHPAGGLY 621
Query: 277 DSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRL 336
+N R V ++P D +D P + + + P H G + V +SP +L
Sbjct: 622 AVGSNSKTLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 675
Query: 337 LATGGMDRRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFAS 390
LATG D+ VK+ E C G G+ + +E +G +L ++
Sbjct: 676 LATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDC 735
Query: 391 RIWTVDDYRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-- 446
I+T D R + H L+GH+G +L A + I SGS D+T++ WDLR C++ V
Sbjct: 736 NIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGT 794
Query: 447 ---FAGSSCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPER 500
GS+ + + + + +G D +DIR +V+ + ++ +P
Sbjct: 795 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 854
Query: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEG 556
LL+ S D +KV DL+ + KQ P G +V+ + D S++++ SA+
Sbjct: 855 HYLLTGSYDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADR 910
Query: 557 SLYIWS 562
++ +W+
Sbjct: 911 TVTLWT 916
>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
Length = 927
Score = 85.9 bits (211), Expect = 1e-16
Identities = 126/546 (23%), Positives = 217/546 (39%), Gaps = 87/546 (15%)
Query: 64 PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122
P + E + D T Q QE + R+++Q+ L + ++R Q++++ NQ D+
Sbjct: 419 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 475
Query: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
+ + E + +Q KL +L L +E AL +G
Sbjct: 476 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 518
Query: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
N VT + + RL +A N S R + + P + +
Sbjct: 519 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 576
Query: 241 EVIVDETSDHT------------------------EETSPVRAISRAATKRLSQPAGGLL 276
VI D E+T VRA++ PAGGL
Sbjct: 577 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVA-------FHPAGGLY 629
Query: 277 DSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRL 336
+N R V ++P D +D P + + + P H G + V +SP +L
Sbjct: 630 AVGSNSKTLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 683
Query: 337 LATGGMDRRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFAS 390
LATG D+ VK+ E C G G+ + +E +G +L ++
Sbjct: 684 LATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDC 743
Query: 391 RIWTVDDYRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-- 446
I+T D R + H L+GH+G +L A + I SGS D+T++ WDLR C++ V
Sbjct: 744 NIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGT 802
Query: 447 ---FAGSSCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPER 500
GS+ + + + + +G D +DIR +V+ + ++ +P
Sbjct: 803 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 862
Query: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEG 556
LL+ S D +KV DL+ + KQ P G +V+ + D S++++ SA+
Sbjct: 863 HYLLTGSYDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADR 918
Query: 557 SLYIWS 562
++ +W+
Sbjct: 919 TVTLWT 924
>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
Length = 920
Score = 85.9 bits (211), Expect = 1e-16
Identities = 126/546 (23%), Positives = 217/546 (39%), Gaps = 87/546 (15%)
Query: 64 PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122
P + E + D T Q QE + R+++Q+ L + ++R Q++++ NQ D+
Sbjct: 412 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 468
Query: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
+ + E + +Q KL +L L +E AL +G
Sbjct: 469 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 511
Query: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
N VT + + RL +A N S R + + P + +
Sbjct: 512 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 569
Query: 241 EVIVDETSDHT------------------------EETSPVRAISRAATKRLSQPAGGLL 276
VI D E+T VRA++ PAGGL
Sbjct: 570 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVA-------FHPAGGLY 622
Query: 277 DSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRL 336
+N R V ++P D +D P + + + P H G + V +SP +L
Sbjct: 623 AVGSNSKTLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 676
Query: 337 LATGGMDRRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFAS 390
LATG D+ VK+ E C G G+ + +E +G +L ++
Sbjct: 677 LATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDC 736
Query: 391 RIWTVDDYRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-- 446
I+T D R + H L+GH+G +L A + I SGS D+T++ WDLR C++ V
Sbjct: 737 NIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGT 795
Query: 447 ---FAGSSCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPER 500
GS+ + + + + +G D +DIR +V+ + ++ +P
Sbjct: 796 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 855
Query: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEG 556
LL+ S D +KV DL+ + KQ P G +V+ + D S++++ SA+
Sbjct: 856 HYLLTGSYDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADR 911
Query: 557 SLYIWS 562
++ +W+
Sbjct: 912 TVTLWT 917
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/266 (24%), Positives = 123/266 (46%), Gaps = 13/266 (4%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSY 380
H G V + Q ++ +G DR +K+W +C +L G + + +
Sbjct: 302 HTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIH--TLYGHTSTVRCMHLHE--KR 355
Query: 381 LLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK 440
+++ S D R+W ++ + H L GH V ++ D R+VSG++D +K+WD ++
Sbjct: 356 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETE 413
Query: 441 VCIKTVFAGSS-CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPE 499
C+ T+ ++ + V+SG D IR WD+ + + + + +T+ + +
Sbjct: 414 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS-GMELK 472
Query: 500 RTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLY 559
L+S + D +K+ D++T QT P K S T + F+ + +V S +G++
Sbjct: 473 DNILVSGNADSTVKIWDIKTGQCLQTLQGPN-KHQSAVTCLQFNKN--FVITSSDDGTVK 529
Query: 560 IWSVLTGKVEKVLSKQHSSSINAVAW 585
+W + TG+ + L S V W
Sbjct: 530 LWDLKTGEFIRNLVTLESGGSGGVVW 555
Score = 80.9 bits (198), Expect = 3e-15
Identities = 65/215 (30%), Positives = 110/215 (51%), Gaps = 22/215 (10%)
Query: 369 ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSH 428
IT ++F G+ +++ S+D ++W+ + TL GH+G V S++ + DN I+SGS
Sbjct: 266 ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQ-MRDNI-IISGST 321
Query: 429 DRTLKLWDLRSKVCIKTVFAGSSCNDIVCT---EQCVMSGHFDKKIRFWDIRSESIVREM 485
DRTLK+W+ + CI T++ +S + C E+ V+SG D +R WDI + +
Sbjct: 322 DRTLKVWNAETGECIHTLYGHTS--TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH-- 377
Query: 486 ELLGKITALD-LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSP 544
L+G + A+ + + ++S + D ++KV D T T T V+S
Sbjct: 378 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG--------HTNRVYSL 429
Query: 545 --DGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHS 577
DG +V +GS + S+ +W V TG L+ S
Sbjct: 430 QFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS 464
Score = 77.8 bits (190), Expect = 3e-14
Identities = 52/178 (29%), Positives = 90/178 (50%), Gaps = 12/178 (6%)
Query: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 374
L V H V VQ+ R + +G D VK+W+ E C +L G + S++F
Sbjct: 376 LHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLH--TLQGHTNRVYSLQF 431
Query: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
D G ++++ S D + R+W V+ HTLTGH + S L DN +VSG+ D T+K+
Sbjct: 432 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS-LTSGMELKDNI-LVSGNADSTVKI 487
Query: 435 WDLRSKVCIKTVFAGSSCNDIVC----TEQCVMSGHFDKKIRFWDIRSESIVREMELL 488
WD+++ C++T+ + V + V++ D ++ WD+++ +R + L
Sbjct: 488 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTL 545
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/266 (24%), Positives = 123/266 (46%), Gaps = 13/266 (4%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSY 380
H G V + Q ++ +G DR +K+W +C +L G + + +
Sbjct: 420 HTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIH--TLYGHTSTVRCMHLHE--KR 473
Query: 381 LLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK 440
+++ S D R+W ++ + H L GH V ++ D R+VSG++D +K+WD ++
Sbjct: 474 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETE 531
Query: 441 VCIKTVFAGSS-CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPE 499
C+ T+ ++ + V+SG D IR WD+ + + + + +T+ + +
Sbjct: 532 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS-GMELK 590
Query: 500 RTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLY 559
L+S + D +K+ D++T QT P K S T + F+ + +V S +G++
Sbjct: 591 DNILVSGNADSTVKIWDIKTGQCLQTLQGPN-KHQSAVTCLQFNKN--FVITSSDDGTVK 647
Query: 560 IWSVLTGKVEKVLSKQHSSSINAVAW 585
+W + TG+ + L S V W
Sbjct: 648 LWDLKTGEFIRNLVTLESGGSGGVVW 673
Score = 80.9 bits (198), Expect = 3e-15
Identities = 65/215 (30%), Positives = 110/215 (51%), Gaps = 22/215 (10%)
Query: 369 ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSH 428
IT ++F G+ +++ S+D ++W+ + TL GH+G V S++ + DN I+SGS
Sbjct: 384 ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQ-MRDNI-IISGST 439
Query: 429 DRTLKLWDLRSKVCIKTVFAGSSCNDIVCT---EQCVMSGHFDKKIRFWDIRSESIVREM 485
DRTLK+W+ + CI T++ +S + C E+ V+SG D +R WDI + +
Sbjct: 440 DRTLKVWNAETGECIHTLYGHTS--TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH-- 495
Query: 486 ELLGKITALD-LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSP 544
L+G + A+ + + ++S + D ++KV D T T T V+S
Sbjct: 496 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG--------HTNRVYSL 547
Query: 545 --DGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHS 577
DG +V +GS + S+ +W V TG L+ S
Sbjct: 548 QFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS 582
Score = 77.8 bits (190), Expect = 3e-14
Identities = 52/178 (29%), Positives = 90/178 (50%), Gaps = 12/178 (6%)
Query: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 374
L V H V VQ+ R + +G D VK+W+ E C +L G + S++F
Sbjct: 494 LHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLH--TLQGHTNRVYSLQF 549
Query: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
D G ++++ S D + R+W V+ HTLTGH + S L DN +VSG+ D T+K+
Sbjct: 550 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS-LTSGMELKDNI-LVSGNADSTVKI 605
Query: 435 WDLRSKVCIKTVFAGSSCNDIVC----TEQCVMSGHFDKKIRFWDIRSESIVREMELL 488
WD+++ C++T+ + V + V++ D ++ WD+++ +R + L
Sbjct: 606 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTL 663
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/266 (24%), Positives = 123/266 (46%), Gaps = 13/266 (4%)
Query: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSY 380
H G V + Q ++ +G DR +K+W +C +L G + + +
Sbjct: 340 HTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIH--TLYGHTSTVRCMHLHE--KR 393
Query: 381 LLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK 440
+++ S D R+W ++ + H L GH V ++ D R+VSG++D +K+WD ++
Sbjct: 394 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETE 451
Query: 441 VCIKTVFAGSS-CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPE 499
C+ T+ ++ + V+SG D IR WD+ + + + + +T+ + +
Sbjct: 452 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS-GMELK 510
Query: 500 RTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLY 559
L+S + D +K+ D++T QT P K S T + F+ + +V S +G++
Sbjct: 511 DNILVSGNADSTVKIWDIKTGQCLQTLQGPN-KHQSAVTCLQFNKN--FVITSSDDGTVK 567
Query: 560 IWSVLTGKVEKVLSKQHSSSINAVAW 585
+W + TG+ + L S V W
Sbjct: 568 LWDLKTGEFIRNLVTLESGGSGGVVW 593
Score = 80.9 bits (198), Expect = 3e-15
Identities = 65/215 (30%), Positives = 110/215 (51%), Gaps = 22/215 (10%)
Query: 369 ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSH 428
IT ++F G+ +++ S+D ++W+ + TL GH+G V S++ + DN I+SGS
Sbjct: 304 ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQ-MRDNI-IISGST 359
Query: 429 DRTLKLWDLRSKVCIKTVFAGSSCNDIVCT---EQCVMSGHFDKKIRFWDIRSESIVREM 485
DRTLK+W+ + CI T++ +S + C E+ V+SG D +R WDI + +
Sbjct: 360 DRTLKVWNAETGECIHTLYGHTS--TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH-- 415
Query: 486 ELLGKITALD-LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSP 544
L+G + A+ + + ++S + D ++KV D T T T V+S
Sbjct: 416 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG--------HTNRVYSL 467
Query: 545 --DGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHS 577
DG +V +GS + S+ +W V TG L+ S
Sbjct: 468 QFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS 502
Score = 77.8 bits (190), Expect = 3e-14
Identities = 52/178 (29%), Positives = 90/178 (50%), Gaps = 12/178 (6%)
Query: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 374
L V H V VQ+ R + +G D VK+W+ E C +L G + S++F
Sbjct: 414 LHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLH--TLQGHTNRVYSLQF 469
Query: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
D G ++++ S D + R+W V+ HTLTGH + S L DN +VSG+ D T+K+
Sbjct: 470 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS-LTSGMELKDNI-LVSGNADSTVKI 525
Query: 435 WDLRSKVCIKTVFAGSSCNDIVC----TEQCVMSGHFDKKIRFWDIRSESIVREMELL 488
WD+++ C++T+ + V + V++ D ++ WD+++ +R + L
Sbjct: 526 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTL 583
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 82.8 bits (203), Expect = 8e-16
Identities = 87/364 (23%), Positives = 144/364 (39%), Gaps = 74/364 (20%)
Query: 307 EVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW-----------EVFGEK 355
+V +P V H+ EV ++P S LLA+G D ++W ++
Sbjct: 154 DVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRH 213
Query: 356 CEFKGSLS-GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
C +G SN +TS++++S G+ L S D +RIWT D L TL H G + +
Sbjct: 214 CIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFAL 272
Query: 415 KFLLDNARIVSGSHDRTLKLWDLRS---------------KVCIKTVFAGSSCNDIVCTE 459
K+ I+S D+T +WD + V ++ +SC+ +C
Sbjct: 273 KWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIH 332
Query: 460 QC---------VMSGHF--------------------DKKIRFWDIRSESIVREMELLGK 490
C GH D ++ W ++ ++ V +++ K
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK 392
Query: 491 -ITALDLNP---------ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV 540
I + +P L S S D +++ D+ T + K V
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLT----KHQEPVYSV 448
Query: 541 VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHV-VSVDKGC 599
FSPDG Y+A+GS + ++IW+ TG + V S + + I V W+ +G V S G
Sbjct: 449 AFSPDGRYLASGSFDKCVHIWNTQTGAL--VHSYRGTGGIFEVCWNAAGDKVGASASDGS 506
Query: 600 KAVL 603
VL
Sbjct: 507 VCVL 510
Score = 59.3 bits (142), Expect = 1e-08
Identities = 40/170 (23%), Positives = 77/170 (45%), Gaps = 12/170 (7%)
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLD- 419
+ G + +I++D G+ L + S+D +IW++ H L H+ ++ + K+
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
Query: 420 --------NARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFD 468
N + S S D T++LWD+ +CI T+ V + + SG FD
Sbjct: 404 PGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463
Query: 469 KKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLR 518
K + W+ ++ ++V G I + N ++ + + D + V+DLR
Sbjct: 464 KCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/222 (21%), Positives = 83/222 (37%), Gaps = 29/222 (13%)
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-----------KVCIKTVFAGSSC 452
L GH +V + + + SGS D T ++W+L + CI+
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 453 NDIVCTEQ------CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSC 506
N V + + +G +D R W + G I AL N + +LS
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 507 SRDDLLKVIDLRTNAIKQTF---SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSV 563
D + D T KQ F SAP DW + A+ S + +++ +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDV--DWQ------SNNTFASCSTDMCIHVCKL 336
Query: 564 LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWA 605
+ K + H++ +NA+ W P+G+ + S +W+
Sbjct: 337 GQDRPIKTF-QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 377
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 82.4 bits (202), Expect = 1e-15
Identities = 85/364 (23%), Positives = 142/364 (39%), Gaps = 74/364 (20%)
Query: 307 EVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW-----------EVFGEK 355
+V +P V H+ EV ++P S LLA+G D ++W ++
Sbjct: 164 DVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 356 CEFKGSLS-GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
C +G SN +TS++++S G+ L S D +RIWT ++ L TL H G + +
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFAL 282
Query: 415 KFLLDNARIVSGSHDRTLKLWDLRS---------------KVCIKTVFAGSSCNDIVCTE 459
K+ ++S D+T +WD + V + +SC+ +C
Sbjct: 283 KWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIH 342
Query: 460 QC---------VMSGHF--------------------DKKIRFWDIRSESIVREMELLGK 490
C GH D ++ W ++ ++ V +++ K
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK 402
Query: 491 -ITALDLNP---------ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRV 540
I + +P L S S D +++ D+ T K V
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL----MKHQEPVYSV 458
Query: 541 VFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHV-VSVDKGC 599
FSPDG Y+A+GS + ++IW+ +G + V S Q + I V W+ G V S G
Sbjct: 459 AFSPDGKYLASGSFDKYVHIWNTQSGSL--VHSYQGTGGIFEVCWNARGDKVGASASDGS 516
Query: 600 KAVL 603
VL
Sbjct: 517 VCVL 520
Score = 60.5 bits (145), Expect = 4e-09
Identities = 41/169 (24%), Positives = 76/169 (44%), Gaps = 12/169 (7%)
Query: 361 SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL-- 418
+ G + +I++D +G L + S+D +IW++ H L HS ++ + K+
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Query: 419 -------DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFD 468
+ + S S D T++LWD+ VC T+ V + + SG FD
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFD 473
Query: 469 KKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDL 517
K + W+ +S S+V + G I + N ++ + + D + V+DL
Sbjct: 474 KYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 40.4 bits (93), Expect = 0.005
Identities = 49/222 (22%), Positives = 80/222 (36%), Gaps = 29/222 (13%)
Query: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-----------KVCIKTVFAGSSC 452
L GH +V + + + SGS D T ++W+L + CI+
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 453 NDIVCTEQ------CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSC 506
N V + + G +D R W + G I AL N + +LS
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 507 SRDDLLKVIDLRTNAIKQTF---SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSV 563
D + D T KQ F SAP DW + A+ S + +++ +
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDV--DWQ------NNMTFASCSTDMCIHVCRL 346
Query: 564 LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWA 605
K + H++ +NA+ W PSG + S +W+
Sbjct: 347 GCDHPVKTF-QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,219,174
Number of Sequences: 37866
Number of extensions: 971778
Number of successful extensions: 8728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 320
Number of HSP's successfully gapped in prelim test: 619
Number of HSP's that attempted gapping in prelim test: 4519
Number of HSP's gapped (non-prelim): 3116
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.