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Search of human proteins with 38454322
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38454322 adhesion molecule with Ig-like domain 3 [Homo
sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens] 1033 0.0
gi|153791466 AMIGO protein [Homo sapiens] 276 3e-74
gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens] 246 5e-65
gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens] 246 5e-65
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 122 8e-28
gi|11321571 slit homolog 3 [Homo sapiens] 100 5e-21
gi|13375646 leucine rich repeat and fibronectin type III domain ... 98 2e-20
gi|188528675 slit homolog 1 [Homo sapiens] 94 3e-19
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 94 4e-19
gi|109150416 peroxidasin [Homo sapiens] 92 1e-18
gi|4759146 slit homolog 2 [Homo sapiens] 90 4e-18
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 90 4e-18
gi|194440719 chondroadherin-like [Homo sapiens] 86 6e-17
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 85 2e-16
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 85 2e-16
gi|27363458 leucine rich repeat and fibronectin type III domain ... 84 2e-16
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 84 4e-16
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 84 4e-16
gi|55741571 leucine rich repeat and fibronectin type III domain ... 83 5e-16
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 83 7e-16
gi|139948432 adlican [Homo sapiens] 83 7e-16
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 83 7e-16
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 82 9e-16
gi|126517478 peroxidasin homolog-like [Homo sapiens] 82 9e-16
gi|52353306 leucine rich repeat containing 55 [Homo sapiens] 81 3e-15
gi|61966761 leucine rich repeat containing 26 [Homo sapiens] 80 4e-15
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 80 4e-15
gi|31542244 leucine rich repeat and fibronectin type III domain ... 80 6e-15
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 79 7e-15
gi|225579152 insulin-like growth factor binding protein, acid la... 79 1e-14
>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
Length = 504
Score = 1033 bits (2671), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELP 60
MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELP
Sbjct: 1 MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELP 60
Query: 61 AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT 120
AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT
Sbjct: 61 AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT 120
Query: 121 LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL 180
LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL
Sbjct: 121 LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL 180
Query: 181 SATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLS 240
SATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLS
Sbjct: 181 SATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLS 240
Query: 241 AVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYC 300
AVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYC
Sbjct: 241 AVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYC 300
Query: 301 NTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLH 360
NTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLH
Sbjct: 301 NTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLH 360
Query: 361 HNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP 420
HNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP
Sbjct: 361 HNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP 420
Query: 421 QTPSPLQELSAQSSVLSTTPPDAPSRKASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLYN 480
QTPSPLQELSAQSSVLSTTPPDAPSRKASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLYN
Sbjct: 421 QTPSPLQELSAQSSVLSTTPPDAPSRKASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLYN 480
Query: 481 PGGLQLKAGSESASSIGSEGPMTT 504
PGGLQLKAGSESASSIGSEGPMTT
Sbjct: 481 PGGLQLKAGSESASSIGSEGPMTT 504
>gi|153791466 AMIGO protein [Homo sapiens]
Length = 493
Score = 276 bits (706), Expect = 3e-74
Identities = 182/483 (37%), Positives = 249/483 (51%), Gaps = 29/483 (6%)
Query: 29 RALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAP-LFQL 87
RA+ +CP C+CA+++LSC+ L +VP LP+ TA LDLSHN L RLR W L QL
Sbjct: 29 RAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQL 88
Query: 88 RALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVH 147
+L L HN L+ + F LR LDLSSN LR L L LE LLL+NN ++
Sbjct: 89 HSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMA 148
Query: 148 LDEHAFHGLRALSHLYLGCNELASFSFDHL-HGLSATHLLTLDLSSNRLGHISVPELAAL 206
+D AF + L LYL N+++ F + + G L LDLSSN+L ++ +P+L L
Sbjct: 149 VDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKL 208
Query: 207 PAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASRVRFFQH 266
PA++KNGLYLHNNPL CDC LY L W R LS+V DF + C+ K F
Sbjct: 209 PAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSK---KLHNVFNL 265
Query: 267 SRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTSVPAMRIAWVSPQQELLRAPGSRD 326
S F NC E E A +G +L + C+T M WV+P E + +
Sbjct: 266 S--FLNCG-------EYKERAWEAHLGDTLIIKCDTKQQGMTKVWVTPSNERV-LDEVTN 315
Query: 327 GSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAFNTGFT 386
G+++V DGSL VQ + G++ C A G + + E V + NT +T
Sbjct: 316 GTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYT 375
Query: 387 TLLGCAVGLVLVLLYLFAPPCRC-CRRACRCRRWPQTPSPLQELSAQSSVLSTTPPDAP- 444
TL+GC + +VLVL+YL+ PCRC CR + PS Q S SS+LSTTP P
Sbjct: 376 TLVGCILSVVLVLIYLYLTPCRCWCRGV-------EKPSSHQGDSLSSSMLSTTPNHDPM 428
Query: 445 ---SRKASVHKHVVFLEPG--RRGLNGRVQLAVAEEFDLYNPGGLQLKAGSESASSIGSE 499
+ + V FLEP +G NG+++ G + + ES SS+ S+
Sbjct: 429 AGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSD 488
Query: 500 GPM 502
P+
Sbjct: 489 TPI 491
>gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]
Length = 522
Score = 246 bits (627), Expect = 5e-65
Identities = 180/511 (35%), Positives = 251/511 (49%), Gaps = 35/511 (6%)
Query: 10 LLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLS 69
LLC+L + + P A CP CICA D++SCT L VP L LDLS
Sbjct: 23 LLCLLMITVTVG------PGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLS 76
Query: 70 HNALQRLRPGWLAPLF-QLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHD 128
+N + L W+ F +L L L HN + ++ G F L+ LDLSSN L+ +
Sbjct: 77 YNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAV 136
Query: 129 LDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFD-HLHGLSATHLLT 187
L LE LLL+NN + +LD AF GL L LYL N L F D ++ L+
Sbjct: 137 FQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMF 196
Query: 188 LDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAR 247
LD+S NR+ + + + +P G+YLH NP CDC LY LL W++R S+V DF
Sbjct: 197 LDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKN 256
Query: 248 EYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLY-ALVGRSLRLYCN--TSV 304
+Y C + + F NCS + G R ++ A VG L ++C+ T
Sbjct: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGN 316
Query: 305 PAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQT 364
WV P LL P + V +GSL I + + + AG++ C+A + N+T
Sbjct: 317 ANTDFIWVGPDNRLLE-PDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNET 375
Query: 365 HEYNVSV-HFPRPEP---EAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP 420
+ ++V +F EAFNT FTTL C +VLVLLYL+ PC C C+ +R
Sbjct: 376 VDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPC---KCKTKR-- 430
Query: 421 QTPSPLQELSAQSSVLSTTP---PDAPSRKASVHKHVVFLEPGR---RGLNGRVQL---- 470
+ L + +A SS+LS P A RKA K VVFLEP + G NG+V+L
Sbjct: 431 -QKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSE 489
Query: 471 AVAEEFDLYNPGGLQLKAGSESASSIGSEGP 501
AV E L + G K+ S+S +S+ S+ P
Sbjct: 490 AVIAEGILKSTRG---KSDSDSVNSVFSDTP 517
>gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]
Length = 522
Score = 246 bits (627), Expect = 5e-65
Identities = 180/511 (35%), Positives = 251/511 (49%), Gaps = 35/511 (6%)
Query: 10 LLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLS 69
LLC+L + + P A CP CICA D++SCT L VP L LDLS
Sbjct: 23 LLCLLMITVTVG------PGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLS 76
Query: 70 HNALQRLRPGWLAPLF-QLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHD 128
+N + L W+ F +L L L HN + ++ G F L+ LDLSSN L+ +
Sbjct: 77 YNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAV 136
Query: 129 LDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFD-HLHGLSATHLLT 187
L LE LLL+NN + +LD AF GL L LYL N L F D ++ L+
Sbjct: 137 FQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMF 196
Query: 188 LDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAR 247
LD+S NR+ + + + +P G+YLH NP CDC LY LL W++R S+V DF
Sbjct: 197 LDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKN 256
Query: 248 EYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLY-ALVGRSLRLYCN--TSV 304
+Y C + + F NCS + G R ++ A VG L ++C+ T
Sbjct: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGN 316
Query: 305 PAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQT 364
WV P LL P + V +GSL I + + + AG++ C+A + N+T
Sbjct: 317 ANTDFIWVGPDNRLLE-PDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNET 375
Query: 365 HEYNVSV-HFPRPEP---EAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP 420
+ ++V +F EAFNT FTTL C +VLVLLYL+ PC C C+ +R
Sbjct: 376 VDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPC---KCKTKR-- 430
Query: 421 QTPSPLQELSAQSSVLSTTP---PDAPSRKASVHKHVVFLEPGR---RGLNGRVQL---- 470
+ L + +A SS+LS P A RKA K VVFLEP + G NG+V+L
Sbjct: 431 -QKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSE 489
Query: 471 AVAEEFDLYNPGGLQLKAGSESASSIGSEGP 501
AV E L + G K+ S+S +S+ S+ P
Sbjct: 490 AVIAEGILKSTRG---KSDSDSVNSVFSDTP 517
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 122 bits (306), Expect = 8e-28
Identities = 137/435 (31%), Positives = 177/435 (40%), Gaps = 54/435 (12%)
Query: 28 PRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQL 87
P CP C C + + C L L+ VP +P T L L N + RL PG LAPL L
Sbjct: 17 PLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAAL 76
Query: 88 RALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVH 147
R L+L +N L AL G F L L L+SN LR L GL L L L N+L
Sbjct: 77 RRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLAR 136
Query: 148 LDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALP 207
L + F L L L+L N + L GLS+ L LDLS N+LG IS L L
Sbjct: 137 LLDFTFLHLPRLQELHLQENSIELLEDQALAGLSS--LALLDLSRNQLGTISREALQPLA 194
Query: 208 AFLKNGLYLHNNPLPCDCRLYHLLQRWHQRG---LSAVRDFAREYVCL-AFKVPASRVRF 263
+ L L NP CDC L H L W + G L RD R+ +C ++ +
Sbjct: 195 SL--QVLRLTENPWRCDCAL-HWLGAWIKEGGQRLLTSRD--RKIMCAEPPRLALQSLLD 249
Query: 264 FQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTS-VPAMRIAW---VSPQQELL 319
HS + S LE L A +G LR+ C S P + W P++
Sbjct: 250 VSHSSLICIPPSVHVQPLE-----LTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRP 304
Query: 320 RAPGSRDGSIAVL--------ADGSLAIGNVQEQHAGLFVCLATGP--------RLHHNQ 363
RA +G + L G L + N+ HAG + C A+ RL N
Sbjct: 305 RAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNA 364
Query: 364 THEYNVSVHFP----------RPEPEAFNTGF-------TTLLGCAVGLV-LVLLYLFAP 405
+ + P P PEA + F T + A+ L+ L L L A
Sbjct: 365 SRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAM 424
Query: 406 PCRCCRRACRCRRWP 420
CR RR + R P
Sbjct: 425 ICRRRRRRKKARGPP 439
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 99.8 bits (247), Expect = 5e-21
Identities = 72/236 (30%), Positives = 103/236 (43%), Gaps = 20/236 (8%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP KC C+A + C GLGL+ VP +P LDL N + R+ A L LR LHL+
Sbjct: 34 CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLE 93
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
N++ + RG F + L L L+ N L+ L L +L L N++ + AF
Sbjct: 94 DNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAF 153
Query: 154 HGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNG 213
G+ + +L L N ++ L +LT L++N + I V +P
Sbjct: 154 RGITDVKNLQLDNNHISCIEDGAFRALRDLEILT--LNNNNISRILVTSFNHMPKI--RT 209
Query: 214 LYLHNNPLPCDCRLYHL----------------LQRWHQRGLSAVRDFAREYVCLA 253
L LH+N L CDC L L + H RG + +EYVC A
Sbjct: 210 LRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPA 265
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/210 (27%), Positives = 90/210 (42%), Gaps = 33/210 (15%)
Query: 21 PDSEGFPPRALHN---CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLR 77
P SE PP N CP C C+ +++ C G GL ++PA LP ++
Sbjct: 266 PHSE--PPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEI----------- 312
Query: 78 PGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEK 137
L+ N + A+ G F L+ +D+S N + + GL +L
Sbjct: 313 -------------RLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTS 359
Query: 138 LLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGH 197
L+L+ N++ + + F GL +L L L N++ + L +LL+ L N+L
Sbjct: 360 LVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLS--LYDNKLQT 417
Query: 198 ISVPELAALPAFLKNGLYLHNNPLPCDCRL 227
IS A L + L+L NP CDC L
Sbjct: 418 ISKGLFAPLQSI--QTLHLAQNPFVCDCHL 445
Score = 76.6 bits (187), Expect = 5e-14
Identities = 48/136 (35%), Positives = 69/136 (50%), Gaps = 1/136 (0%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP +C C ++ C+ GL+ +P +P +L L N L + P L+ L L + L
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLS 783
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
+N + L F N S L L LS N LR + H +GL +L L L N + + E +F
Sbjct: 784 NNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSF 843
Query: 154 HGLRALSHLYLGCNEL 169
+ L +LSHL LG N L
Sbjct: 844 NDLTSLSHLALGTNPL 859
Score = 73.9 bits (180), Expect = 3e-13
Identities = 53/194 (27%), Positives = 84/194 (43%), Gaps = 27/194 (13%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP KC C ++ C+ L +P+ LP DL L+ N + L
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLE---------------- 548
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
G+F LR ++LS+N ++ + DG ++++L+L N+L + F
Sbjct: 549 -------ATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVF 601
Query: 154 HGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNG 213
GL L L L N + S D GLS+ LL+ L NR+ I+ L + +
Sbjct: 602 RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLS--LYDNRITTITPGAFTTLVSL--ST 657
Query: 214 LYLHNNPLPCDCRL 227
+ L +NP C+C L
Sbjct: 658 INLLSNPFNCNCHL 671
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 98.2 bits (243), Expect = 2e-20
Identities = 121/422 (28%), Positives = 156/422 (36%), Gaps = 70/422 (16%)
Query: 4 LVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLS----CTGLGLQDVPAEL 59
+ +L LLC+L + + + P CP +C C L C G GL VP L
Sbjct: 1 MAILPLLLCLLPLAPASSPPQSATPSP---CPRRCRCQTQSLPLSVLCPGAGLLFVPPSL 57
Query: 60 PAATAD------------------------LDLSHNALQRLRPGWLAPLFQLRALHLDHN 95
A+ L LS N ++ + G A L LRALHLD N
Sbjct: 58 DRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGN 117
Query: 96 ELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLG-ALEKLLLFNNRLVHLDEHAFH 154
L +LG G LR L LS+N L AL LD LE L L N L L A
Sbjct: 118 RLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALG 177
Query: 155 GLRALSHLYLGCNELASF---SFDHLHGLSATHLLTLDLSSNRLGHISV-PELAALPAFL 210
L ++ L L N LAS +F LH L+ LD++SNRL I P + LP
Sbjct: 178 RLGNVNTLGLDHNLLASVPAGAFSRLHKLA-----RLDMTSNRLTTIPPDPLFSRLPLLA 232
Query: 211 KNG--------LYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASRVR 262
+ L NPL C+C L L + + L A PA R
Sbjct: 233 RPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEA-----------CASPPALGGR 281
Query: 263 FFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLRA 321
+F E P + P L GR L C P R+ WVSPQ LL
Sbjct: 282 YFWAVGEEEFVCEPPVVTHRSPP--LAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLL-- 337
Query: 322 PGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAF 381
+G+L + + G+F C+A E V P P P+
Sbjct: 338 --GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVG---PPPPPQLA 392
Query: 382 NT 383
N+
Sbjct: 393 NS 394
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 94.0 bits (232), Expect = 3e-19
Identities = 66/204 (32%), Positives = 91/204 (44%), Gaps = 4/204 (1%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP C C + C G GLQ +P +P T L+L+ N + R+ A L QLR L L
Sbjct: 34 CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLM 93
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
N++ A+ RG F + L L L+ N L L AL +L L N + + AF
Sbjct: 94 ENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAF 153
Query: 154 HGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNG 213
G L +L L N+++ L +LT L++N + I V +P
Sbjct: 154 RGATDLKNLQLDKNQISCIEEGAFRALRGLEVLT--LNNNNITTIPVSSFNHMPKL--RT 209
Query: 214 LYLHNNPLPCDCRLYHLLQRWHQR 237
LH+N L CDC L L Q QR
Sbjct: 210 FRLHSNHLFCDCHLAWLSQWLRQR 233
Score = 88.6 bits (218), Expect = 1e-17
Identities = 59/191 (30%), Positives = 98/191 (51%), Gaps = 11/191 (5%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRP-GWLAPLFQLRALHL 92
CP+KC C A+++ C+ L L +P +P +TA+L L++N + L G L L+ ++L
Sbjct: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINL 572
Query: 93 DHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHA 152
+N++ + G F A+ + L L++N L ++ GL L L+L NNR+ + +
Sbjct: 573 SNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDS 632
Query: 153 FHGLRALSHLYLGCNELASFS---FDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAF 209
F GLR + L L N++ + S FD L LS +LL + N +LA L +
Sbjct: 633 FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCN-------CQLAWLGGW 685
Query: 210 LKNGLYLHNNP 220
L+ + NP
Sbjct: 686 LRKRKIVTGNP 696
Score = 79.0 bits (193), Expect = 1e-14
Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 28/195 (14%)
Query: 33 NCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHL 92
+CP C C+ ++ C G GL +PA LP ++ L N ++ + PG +P +LR
Sbjct: 281 SCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRR--- 337
Query: 93 DHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHA 152
+DLS+N + + GL +L L+L+ N++ L
Sbjct: 338 ---------------------IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGV 376
Query: 153 FHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKN 212
F GL L L L N++ D L +L L L N++ ++ +L A
Sbjct: 377 FGGLYTLQLLLLNANKINCIRPDAFQDLQ--NLSLLSLYDNKIQSLAKGTFTSLRAI--Q 432
Query: 213 GLYLHNNPLPCDCRL 227
L+L NP CDC L
Sbjct: 433 TLHLAQNPFICDCNL 447
Score = 70.5 bits (171), Expect = 3e-12
Identities = 48/149 (32%), Positives = 72/149 (48%), Gaps = 3/149 (2%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP +C C ++ C+ L+ +P +P +L L N L PG L+ L+ + L
Sbjct: 734 CPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFT-LVPGQLSTFKYLQLVDLS 792
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
+N++ +L F N S L L LS N L+ + GL +L L L N + L E F
Sbjct: 793 NNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIF 852
Query: 154 HGLRALSHLYLGCNELASFSFDHLHGLSA 182
+ +LSHL +G N L + HL LS+
Sbjct: 853 ADVTSLSHLAIGANPL--YCDCHLRWLSS 879
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 93.6 bits (231), Expect = 4e-19
Identities = 72/219 (32%), Positives = 102/219 (46%), Gaps = 10/219 (4%)
Query: 7 LGTLLCM-LRVGLGTPDSEGFPPRALHNCPYKCICAAD-----LLSCTGLGLQDVPAELP 60
LG LL + + + L T S L CP C C D + C+ LGL ++P+ L
Sbjct: 6 LGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLS 65
Query: 61 AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT 120
T+ LDLS N + +L P L L L L L N L + +G F L++L L +N
Sbjct: 66 VFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ 125
Query: 121 LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL 180
LR + L L +L+ L L N + ++ F GL +L HL+L N L L
Sbjct: 126 LRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSL 185
Query: 181 SATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNN 219
SA +TL L N++ HI L + + L+LHNN
Sbjct: 186 SALQAMTLAL--NKIHHIPDYAFGNLSSLVV--LHLHNN 220
Score = 50.4 bits (119), Expect = 4e-06
Identities = 44/156 (28%), Positives = 69/156 (44%), Gaps = 5/156 (3%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L L N + + P + L LR L LD N L + F + S L+ + L+ N + +
Sbjct: 143 LRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
+ L +L L L NNR+ L + F GL +L L L N L F + LS +L
Sbjct: 203 DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP-TAIRTLS--NL 259
Query: 186 LTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
L SN + I P+ + ++ ++NP+
Sbjct: 260 KELGFHSNNIRSIPEKAFVGNPSLIT--IHFYDNPI 293
Score = 39.3 bits (90), Expect = 0.008
Identities = 51/213 (23%), Positives = 88/213 (41%), Gaps = 23/213 (10%)
Query: 87 LRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLV 146
L+ L L +N L+ L F L+ +DL N + + L +L L L N++
Sbjct: 354 LQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411
Query: 147 HLDEHAFHGLRALSHLYLGCNELASFSFDHLHG-----LSATHLLTLDLSSNRLGHISVP 201
+ +AF L +L L L N L+SF LHG L+ H L +SS + V
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVI 471
Query: 202 ELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASR- 260
E+ G+ C+ Y + +W++ S++ D ++ + F+ R
Sbjct: 472 EMPYAYQCCAFGV--------CE-NAYKISNQWNKGDNSSMDDLHKKDAGM-FQAQDERD 521
Query: 261 -----VRFFQHSRVFENCSSAPALGLERPEEHL 288
+ F + + + +P+ G +P EHL
Sbjct: 522 LEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHL 554
Score = 37.4 bits (85), Expect = 0.032
Identities = 26/86 (30%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 52 LQDVPA-ELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASG 110
L+D+P+ + +DL HN + ++ L LR+L+L N++ + F
Sbjct: 364 LEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPS 423
Query: 111 LRLLDLSSNTLRALGRHDLDGLGALE 136
L LDLSSN L + L GL L+
Sbjct: 424 LIKLDLSSNLLSSFPITGLHGLTHLK 449
Score = 35.0 bits (79), Expect = 0.16
Identities = 41/161 (25%), Positives = 65/161 (40%), Gaps = 9/161 (5%)
Query: 40 CAADLLSCTGLGLQD-VPAELP-------AATADLDLSHNALQRLRPGWLAPLFQLRALH 91
C + L S L L D E+P +A + L+ N + + L L LH
Sbjct: 157 CFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLH 216
Query: 92 LDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEH 151
L +N + +LG+ F L LDL+ N L + L L++L +N + + E
Sbjct: 217 LHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEK 275
Query: 152 AFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSS 192
AF G +L ++ N + L LTL+ +S
Sbjct: 276 AFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGAS 316
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 92.0 bits (227), Expect = 1e-18
Identities = 86/331 (25%), Positives = 140/331 (42%), Gaps = 57/331 (17%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP +C+C + C L L+ VPA P T+ LDL N ++ ++PG L L L L+
Sbjct: 36 CPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLRFNRIREIQPGAFRRLRNLNTLLLN 94
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
+N++ + G F + L+ L L N ++++ R GL +LE+L L N++ LD +F
Sbjct: 95 NNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSF 154
Query: 154 HGLRALSHLYLGCNELASF---SFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFL 210
L L L+L N + +F+HL +
Sbjct: 155 QHLPKLERLFLHNNRITHLVPGTFNHLESMKR---------------------------- 186
Query: 211 KNGLYLHNNPLPCDCR---LYHLLQRWHQRG---LSAVRDFAREYVCLAFKVPASRVRFF 264
L L +N L CDC L LL+ + + G +A+ ++ R ++ V
Sbjct: 187 ---LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPR-------RIQGRSVATI 236
Query: 265 QHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNT-SVPAMRIAWVSPQQELLRAPG 323
+ NC P + E + + + G ++ C P I W+ EL
Sbjct: 237 TPEEL--NC-ERPRITSEPQDADVTS--GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD 291
Query: 324 SRDGSIAVLADGSLAIGNVQEQHAGLFVCLA 354
SR + +L DG+L I N QE G++ C+A
Sbjct: 292 SR---LNLLDDGTLMIQNTQETDQGIYQCMA 319
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 90.1 bits (222), Expect = 4e-18
Identities = 68/231 (29%), Positives = 102/231 (44%), Gaps = 7/231 (3%)
Query: 7 LGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADL 66
+G + L +GL P+A CP +C C+ + C GL L+ VP +P T L
Sbjct: 4 VGWQMLSLSLGLVLAILNKVAPQA---CPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 60
Query: 67 DLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGR 126
DL+ N + R+ A L LR L L N++ + RG F + L L L+ N L+
Sbjct: 61 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 120
Query: 127 HDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLL 186
G L +L L N++ + AF G + +L L N+++ L +L
Sbjct: 121 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 180
Query: 187 TLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQR 237
T L++N + +SV +P LH+N L CDC L L QR
Sbjct: 181 T--LNNNNITRLSVASFNHMPKL--RTFRLHSNNLYCDCHLAWLSDWLRQR 227
Score = 85.5 bits (210), Expect = 1e-16
Identities = 57/209 (27%), Positives = 92/209 (44%), Gaps = 28/209 (13%)
Query: 27 PPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQ 86
P ++ +CP C C+ +++ C G GL ++P LP ++ L N ++ + PG +P +
Sbjct: 266 PSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKK 325
Query: 87 LRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLV 146
LR + DLS+N + L GL +L L+L+ N++
Sbjct: 326 LRRI------------------------DLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 361
Query: 147 HLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAAL 206
L + F GL +L L L N++ D L +LL+ L N+L I+ + L
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLS--LYDNKLQTIAKGTFSPL 419
Query: 207 PAFLKNGLYLHNNPLPCDCRLYHLLQRWH 235
A ++L NP CDC L L H
Sbjct: 420 RAI--QTMHLAQNPFICDCHLKWLADYLH 446
Score = 73.6 bits (179), Expect = 4e-13
Identities = 48/139 (34%), Positives = 67/139 (48%), Gaps = 1/139 (0%)
Query: 31 LHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRAL 90
L CP +C C ++ C+ GL+ +P +P +L L N L P L+ L +
Sbjct: 724 LSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT-LVPKELSNYKHLTLI 782
Query: 91 HLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDE 150
L +N + L F N + L L LS N LR + DGL +L L L N + + E
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842
Query: 151 HAFHGLRALSHLYLGCNEL 169
AF+ L ALSHL +G N L
Sbjct: 843 GAFNDLSALSHLAIGANPL 861
Score = 69.3 bits (168), Expect = 8e-12
Identities = 54/195 (27%), Positives = 84/195 (43%), Gaps = 29/195 (14%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRP-GWLAPLFQLRALHL 92
CP KC C + C+ L +P +P TA+L L++N L G L QLR ++
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
Query: 93 DHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHA 152
+N++ + G F ASG+ ++LL +NRL ++
Sbjct: 566 SNNKITDIEEGAFEGASGVN------------------------EILLTSNRLENVQHKM 601
Query: 153 FHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKN 212
F GL +L L L N + D GLS+ LL+ L N++ ++ L + +
Sbjct: 602 FKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLS--LYDNQITTVAPGAFDTLHSL--S 657
Query: 213 GLYLHNNPLPCDCRL 227
L L NP C+C L
Sbjct: 658 TLNLLANPFNCNCYL 672
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 90.1 bits (222), Expect = 4e-18
Identities = 81/224 (36%), Positives = 103/224 (45%), Gaps = 18/224 (8%)
Query: 11 LCMLRVGLGTPDSEGFPPRALHNCPYKCICAAD--LLS--CTGLGLQDVPAELPAATADL 66
LC R G P G P A CP C C D +LS C+ LGL VP +L TA L
Sbjct: 16 LCASRRAGGAPQP-GPGPTA---CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYL 71
Query: 67 DLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGR 126
DLS N L L+PG L L L L N L + F L++L L +N L +
Sbjct: 72 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131
Query: 127 HDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLL 186
L L +L+ L L N + + E +F GL +L HL+L N L L+ L A +
Sbjct: 132 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 191
Query: 187 TLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHL 230
TL L NR+ HI P+ A L+LHNN R+ HL
Sbjct: 192 TLAL--NRISHI--PDYAFQNLTSLVVLHLHNN------RIQHL 225
Score = 50.8 bits (120), Expect = 3e-06
Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 17/160 (10%)
Query: 19 GTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPA----ELPAATADLDLSHNALQ 74
G D + FP K + ++L+ T G++ +P+ +LP L+LSHN ++
Sbjct: 314 GAMDIQEFPD-------LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV-LELSHNQIE 365
Query: 75 RLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGA 134
L L +L + L HN + +G F S L+ LDLS N +R++ L +
Sbjct: 366 ELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 423
Query: 135 LEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSF 174
L KL L +N+L L GL L HL L N S +F
Sbjct: 424 LVKLDLTDNQLTTL---PLAGLGGLMHLKLKGNLALSQAF 460
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 86.3 bits (212), Expect = 6e-17
Identities = 69/194 (35%), Positives = 91/194 (46%), Gaps = 6/194 (3%)
Query: 30 ALHNCPYKCIC--AADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQL 87
A CP CIC + ++C L +VP +P T LDL N L+ + + L
Sbjct: 29 AAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHL 88
Query: 88 RALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVH 147
L L H E++ + G F L LL+L+SN LR L + LDGLG+L +L L N L
Sbjct: 89 THLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEE 148
Query: 148 LDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALP 207
L F L AL+ L L N L GL + L LS N L ++ LA LP
Sbjct: 149 LRPGTFGALGALATLNLAHNALVYLPAMAFQGL--LRVRWLRLSHNALSVLAPEALAGLP 206
Query: 208 AFLKNGLYLHNNPL 221
A + L LH+N L
Sbjct: 207 ALRR--LSLHHNEL 218
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/229 (31%), Positives = 89/229 (38%), Gaps = 31/229 (13%)
Query: 19 GTPDSEGFPPRALHNCPYKCICAADLL--SCTGLGLQDVPAELPAATADLDLSHNALQRL 76
G P G RA+ CP C+C + SC G GLQ VP P+ T LDL N +
Sbjct: 382 GPPRGPG-EERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSV 440
Query: 77 RPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALE 136
L L +LHL H + L G L L LS N L L L+G L
Sbjct: 441 PRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLG 500
Query: 137 KLLLFNNRL----------------VHLDEHAFHGL--------RALSHLYLGCNELASF 172
L L NR +HL ++A L RAL +YL N +
Sbjct: 501 YLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEV 560
Query: 173 SFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
S L A L L L N+L + L LPA L+ L L NPL
Sbjct: 561 SLGALG--PARELEKLHLDRNQLREVPTGALEGLPALLE--LQLSGNPL 605
Score = 66.6 bits (161), Expect = 5e-11
Identities = 61/171 (35%), Positives = 80/171 (46%), Gaps = 9/171 (5%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L L NA+ RL PG L LR ++L N + + G A L L L N LR +
Sbjct: 526 LHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGL-RALSHLYLGCNELASFSFDHLHGLSATH 184
L+GL AL +L L N L L + AF + R+L HL+L + L GL
Sbjct: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGL-GPG 644
Query: 185 LLTLDLSSNRLGHISVPELAALPAFLKNGLY-LHNNPLPCDCRLYHLLQRW 234
L +L L N+L L ALP+ + L L +NP CDC+L L RW
Sbjct: 645 LQSLHLQKNQL-----RALPALPSLSQLELIDLSSNPFHCDCQLLP-LHRW 689
Score = 64.3 bits (155), Expect = 2e-10
Identities = 69/204 (33%), Positives = 83/204 (40%), Gaps = 33/204 (16%)
Query: 58 ELPAATAD-------LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASG 110
ELP D L+L NAL+ LRPG L L L+L HN L L F
Sbjct: 124 ELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLR 183
Query: 111 LRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELA 170
+R L LS N L L L GL AL +L L +N L L R L+ L LG N L
Sbjct: 184 VRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLT 243
Query: 171 SFSFDH---LHGL-------------------SATHLLTLDLSSNRLGHISVPELAALPA 208
+ L GL L TLDL N+L ++P L P
Sbjct: 244 YAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLD--TLPPLQG-PG 300
Query: 209 FLKNGLYLHNNPLPCDCRLYHLLQ 232
L+ L L NPL C C+ LL+
Sbjct: 301 QLRR-LRLQGNPLWCGCQARPLLE 323
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/174 (34%), Positives = 82/174 (47%), Gaps = 9/174 (5%)
Query: 30 ALHNCPYKCICA-ADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLR 88
A H CP +C C+ A + CTG + VP LP L + + + L + L
Sbjct: 27 AYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALI 86
Query: 89 ALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHL 148
AL ++ NEL + G F N LR L L++N L+ L GL +LE LLL +N+L+ +
Sbjct: 87 ALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQI 146
Query: 149 DEHAFHGLRALSHLYLGCNELASF---SFDHLHGLSATHLLTLDLSSNRLGHIS 199
F L L L N L +FDHL GL+ L+L N L HIS
Sbjct: 147 QPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT-----KLNLGKNSLTHIS 195
Score = 57.0 bits (136), Expect = 4e-08
Identities = 54/180 (30%), Positives = 77/180 (42%), Gaps = 7/180 (3%)
Query: 45 LSCTGLGLQDVPAELPAATADLD---LSHNALQRLRPGWLAPLFQLRALHLDHNELDALG 101
LS LQ +P L L+ LS N L +++P + L+ L L N L+ +
Sbjct: 112 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171
Query: 102 RGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSH 161
G F + GL L+L N+L + LG L+ L L+ NRL + F GL L
Sbjct: 172 DGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQE 231
Query: 162 LYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
L L N++ S H + +L L LS+N + + LP N L L N L
Sbjct: 232 LALQQNQIGLLSPGLFH--NNHNLQRLYLSNNHISQLPPSIFMQLPQL--NRLTLFGNSL 287
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/175 (30%), Positives = 77/175 (44%), Gaps = 15/175 (8%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L LS+N + +L P L QL L L N L L G+F LR L L N + +L
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
+ L L+ L+L N++ + AF+GL L L L N L + L+ +L
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLA--NL 373
Query: 186 LTLDLSSNRL----GHISVPELAALPAFLKN--------GLYLHNNPLPCDCRLY 228
+ L +NRL G+I + L+N G++ H L C+ RLY
Sbjct: 374 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL-CELRLY 427
Score = 47.0 bits (110), Expect = 4e-05
Identities = 48/156 (30%), Positives = 65/156 (41%), Gaps = 4/156 (2%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L L N L + G L L+ L L N++ L G+F N L+ L LS+N + L
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
L L +L LF N L L F + L L+L N ++S + L L
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL--RQL 325
Query: 186 LTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
L LS N++ IS L + L LH N L
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRE--LSLHTNAL 359
Score = 42.7 bits (99), Expect = 8e-04
Identities = 28/79 (35%), Positives = 39/79 (49%)
Query: 65 DLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124
+L L NALQ L L L+ + L +N L L +F N +GL + L +N L L
Sbjct: 351 ELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENL 410
Query: 125 GRHDLDGLGALEKLLLFNN 143
D LG L +L L++N
Sbjct: 411 PLGIFDHLGKLCELRLYDN 429
Score = 29.3 bits (64), Expect = 8.8
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 7/97 (7%)
Query: 52 LQDVPAELPAATADLD---LSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNA 108
LQD+ + A+L L +N L++L A + L A+ L +N+L+ L G+F +
Sbjct: 359 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHL 418
Query: 109 SGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRL 145
L L L N R D D L LLL RL
Sbjct: 419 GKLCELRLYDNPWRC----DSDILPLRNWLLLNQPRL 451
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/174 (34%), Positives = 82/174 (47%), Gaps = 9/174 (5%)
Query: 30 ALHNCPYKCICA-ADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLR 88
A H CP +C C+ A + CTG + VP LP L + + + L + L
Sbjct: 21 AYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALI 80
Query: 89 ALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHL 148
AL ++ NEL + G F N LR L L++N L+ L GL +LE LLL +N+L+ +
Sbjct: 81 ALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQI 140
Query: 149 DEHAFHGLRALSHLYLGCNELASF---SFDHLHGLSATHLLTLDLSSNRLGHIS 199
F L L L N L +FDHL GL+ L+L N L HIS
Sbjct: 141 QPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT-----KLNLGKNSLTHIS 189
Score = 57.0 bits (136), Expect = 4e-08
Identities = 54/180 (30%), Positives = 77/180 (42%), Gaps = 7/180 (3%)
Query: 45 LSCTGLGLQDVPAELPAATADLD---LSHNALQRLRPGWLAPLFQLRALHLDHNELDALG 101
LS LQ +P L L+ LS N L +++P + L+ L L N L+ +
Sbjct: 106 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165
Query: 102 RGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSH 161
G F + GL L+L N+L + LG L+ L L+ NRL + F GL L
Sbjct: 166 DGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQE 225
Query: 162 LYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
L L N++ S H + +L L LS+N + + LP N L L N L
Sbjct: 226 LALQQNQIGLLSPGLFH--NNHNLQRLYLSNNHISQLPPSIFMQLPQL--NRLTLFGNSL 281
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/175 (30%), Positives = 77/175 (44%), Gaps = 15/175 (8%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L LS+N + +L P L QL L L N L L G+F LR L L N + +L
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
+ L L+ L+L N++ + AF+GL L L L N L + L+ +L
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLA--NL 367
Query: 186 LTLDLSSNRL----GHISVPELAALPAFLKN--------GLYLHNNPLPCDCRLY 228
+ L +NRL G+I + L+N G++ H L C+ RLY
Sbjct: 368 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL-CELRLY 421
Score = 47.0 bits (110), Expect = 4e-05
Identities = 48/156 (30%), Positives = 65/156 (41%), Gaps = 4/156 (2%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L L N L + G L L+ L L N++ L G+F N L+ L LS+N + L
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
L L +L LF N L L F + L L+L N ++S + L L
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL--RQL 319
Query: 186 LTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
L LS N++ IS L + L LH N L
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRE--LSLHTNAL 353
Score = 42.7 bits (99), Expect = 8e-04
Identities = 28/79 (35%), Positives = 39/79 (49%)
Query: 65 DLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124
+L L NALQ L L L+ + L +N L L +F N +GL + L +N L L
Sbjct: 345 ELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENL 404
Query: 125 GRHDLDGLGALEKLLLFNN 143
D LG L +L L++N
Sbjct: 405 PLGIFDHLGKLCELRLYDN 423
Score = 29.3 bits (64), Expect = 8.8
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 7/97 (7%)
Query: 52 LQDVPAELPAATADLD---LSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNA 108
LQD+ + A+L L +N L++L A + L A+ L +N+L+ L G+F +
Sbjct: 353 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHL 412
Query: 109 SGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRL 145
L L L N R D D L LLL RL
Sbjct: 413 GKLCELRLYDNPWRC----DSDILPLRNWLLLNQPRL 445
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 84.3 bits (207), Expect = 2e-16
Identities = 101/359 (28%), Positives = 137/359 (38%), Gaps = 54/359 (15%)
Query: 34 CPYKCICA--ADLLS--CTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRA 89
CP C+C ++ LS C GL VP + T +L L+ N +Q L P + L
Sbjct: 17 CPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVD 76
Query: 90 LHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLD 149
L L N + +G F + LR L L N L LG L G L+ L+L N+L +
Sbjct: 77 LTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIA 136
Query: 150 EHAFHG-LRALSHLYLGCNELASFSFDHLHGLSATHLLTLD------------------- 189
AF L +L L L N L + + + A H L LD
Sbjct: 137 PGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLS 196
Query: 190 ---LSSNRLGHISVPEL-------AALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGL 239
L+SNRL ++ L A PA L L NPL C+C L L R L
Sbjct: 197 RLDLTSNRLATLAPDPLFSRGRDAEASPAPLV--LSFSGNPLHCNCELLWL------RRL 248
Query: 240 SAVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLY 299
+ D C + P R+F E P + R + L+ L G+ L
Sbjct: 249 ARPDDLE---TCAS--PPGLAGRYFWAVPEGEFSCEPPLIA--RHTQRLWVLEGQRATLR 301
Query: 300 CNT-SVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGP 357
C PA + WV P L+ +G+L IG AG + C+AT P
Sbjct: 302 CRALGDPAPTMHWVGPDDRLV----GNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNP 356
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 83.6 bits (205), Expect = 4e-16
Identities = 71/208 (34%), Positives = 103/208 (49%), Gaps = 12/208 (5%)
Query: 7 LGTLLCMLRVGLGTPDSEGFPP-------RALHNCPYKCICAADLLSCTGLGLQDVPAEL 59
LG LLC + G DS G A CP C C DLL C+ L +P L
Sbjct: 13 LGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPL 72
Query: 60 PAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSN 119
P+ A LDLSHN L ++ ++ L LR + L++NEL+ + V+A+ + LL L+ N
Sbjct: 73 PSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSAN-ITLLSLAGN 131
Query: 120 TLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHG 179
+ + L +LE L L +N + L + AF L+ L +LYL N + S +
Sbjct: 132 RIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDN 189
Query: 180 LSATHLLTLDLSSNRLGHISVPELAALP 207
L+ T LL L L+ NR+ I P++ LP
Sbjct: 190 LANT-LLVLKLNRNRISAIP-PKMFKLP 215
Score = 65.5 bits (158), Expect = 1e-10
Identities = 56/191 (29%), Positives = 81/191 (42%), Gaps = 25/191 (13%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L L HN L + GWL L L+ LHL N ++ + + L LDL+ N L L
Sbjct: 268 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 327
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL--SAT 183
GL L L + NNR+ ++ + AF GL +L L L NE+ S++ + ++G
Sbjct: 328 DSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI-SWTIEDMNGAFSGLD 386
Query: 184 HLLTLDLSSNRLGHISVPELAALPAF----------------------LKNGLYLHNNPL 221
L L L NR+ I+ L A L+L+ + L
Sbjct: 387 KLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Query: 222 PCDCRLYHLLQ 232
CDC+L L Q
Sbjct: 447 LCDCQLKWLPQ 457
Score = 57.0 bits (136), Expect = 4e-08
Identities = 41/134 (30%), Positives = 63/134 (47%), Gaps = 2/134 (1%)
Query: 62 ATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTL 121
A L + N + +L G L + L LDHN L + +G L+ L LS N +
Sbjct: 240 ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAI 299
Query: 122 RALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLS 181
+ + L +L L N L LD+ +F GL L+ L++G N ++ + GLS
Sbjct: 300 NRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 359
Query: 182 ATHLLTLDLSSNRL 195
+ L TLDL +N +
Sbjct: 360 S--LKTLDLKNNEI 371
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/125 (32%), Positives = 63/125 (50%), Gaps = 4/125 (3%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVN-ASGLRLLDLSSNTLRAL 124
LDLS N + L+ + P QL+ L+L+ N + ++ G F N A+ L +L L+ N + A+
Sbjct: 150 LDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAI 207
Query: 125 GRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATH 184
+ L L+ L L N++ ++D F GL AL L + N + GLS
Sbjct: 208 PPK-MFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNME 266
Query: 185 LLTLD 189
+L LD
Sbjct: 267 ILQLD 271
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 83.6 bits (205), Expect = 4e-16
Identities = 70/204 (34%), Positives = 92/204 (45%), Gaps = 18/204 (8%)
Query: 3 WLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADL--LSCTGLGLQDVPAELP 60
WL +L L +L PP A CP +C C ++CT L VP +P
Sbjct: 4 WLCVLSLPLLLLPAA---------PPPA-GGCPARCECTVQTRAVACTRRRLTAVPDGIP 53
Query: 61 AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT 120
A T L+LS N ++ L PG LA L L L L N + + G F N LR+L L N
Sbjct: 54 AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113
Query: 121 LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL 180
L+ + L L L L N+LV L ++ F L +L L +G N+L S GL
Sbjct: 114 LKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173
Query: 181 SATHLLTLD------LSSNRLGHI 198
A LTL+ LS LGH+
Sbjct: 174 LALEELTLERCNLTALSGESLGHL 197
Score = 73.9 bits (180), Expect = 3e-13
Identities = 80/312 (25%), Positives = 122/312 (39%), Gaps = 41/312 (13%)
Query: 73 LQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGL 132
L+ + G L L L +L + H + A+ + + L L+LS N + + R L
Sbjct: 235 LEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDL 293
Query: 133 GALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSS 192
L +L L L ++ AF GLR + L L N L++ H ++ L +D
Sbjct: 294 VRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVD--- 350
Query: 193 NRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCL 252
NPL CDCRL ++QR D
Sbjct: 351 -------------------------GNPLACDCRLLWIVQRRKTLNF----DGRLPACAT 381
Query: 253 AFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNT-SVPAMRIAW 311
+V +R S +FE ER + + A G +R C PA +AW
Sbjct: 382 PAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAW 441
Query: 312 VSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSV 371
V+PQ + A + G VL G+L I + + Q +G + C+A+ N T+ ++V
Sbjct: 442 VTPQHRPVTATSA--GRARVLPGGTLEIQDARPQDSGTYTCVAS--NAGGNDTYFATLTV 497
Query: 372 HFPRPEPEAFNT 383
RPEP A T
Sbjct: 498 ---RPEPAANRT 506
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 83.2 bits (204), Expect = 5e-16
Identities = 99/359 (27%), Positives = 138/359 (38%), Gaps = 56/359 (15%)
Query: 34 CPYKCICA--ADLLS--CTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRA 89
CP C+C ++ L C GL VP ++ T +L L N + + A + L
Sbjct: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
Query: 90 LHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLD 149
L L N + + F++ LR L L SN L +LG L GL L+ L++ NN+L +
Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
Query: 150 EHAFHG-LRALSHLYLGCNELASFSFD------HLHGLSATH----------------LL 186
+ AF L L L L N L +D +LH LS H L
Sbjct: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
Query: 187 TLDLSSNRLGHI---------SVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQR 237
LDL+SNRL + L A P NPL C+C L L
Sbjct: 201 RLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWL------- 253
Query: 238 GLSAVRDFAREYVCLAFKVPAS-RVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSL 296
R R+ P + R+F H R E P + + L L G++
Sbjct: 254 -----RRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPL--ITQHTHKLLVLEGQAA 306
Query: 297 RLYCNT-SVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLA 354
L C P+ I WV+P L+ AV +G+L I Q +G F C+A
Sbjct: 307 TLKCKAIGDPSPLIHWVAPDDRLV----GNSSRTAVYDNGTLDIFITTSQDSGAFTCIA 361
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 82.8 bits (203), Expect = 7e-16
Identities = 83/264 (31%), Positives = 107/264 (40%), Gaps = 63/264 (23%)
Query: 34 CPYKCICAAD---LLSCTGLGLQDVPAELPAATA-------------------------- 64
CP C+C + SC GLQ VP +PAA+
Sbjct: 27 CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86
Query: 65 ----------------------DLDLSHNA-LQRLRPGWLAPLFQLRALHLDHNELDALG 101
LDLS NA L+ + P L +L LHLD L LG
Sbjct: 87 WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146
Query: 102 RGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSH 161
G+F + L+ L L N L+AL LG L L L NR+ + E AF GL +L
Sbjct: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206
Query: 162 LYLGCNELASFSFDHLHGL-SATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNP 220
L L N +A H H L+TL L +N L + LA L A L L++NP
Sbjct: 207 LLLHQNRVAHV---HPHAFRDLGRLMTLYLFANNLSALPTEALAPLRAL--QYLRLNDNP 261
Query: 221 LPCDCR---LYHLLQRWHQRGLSA 241
CDCR L+ LQ++ RG S+
Sbjct: 262 WVCDCRARPLWAWLQKF--RGSSS 283
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 82.8 bits (203), Expect = 7e-16
Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 9/212 (4%)
Query: 28 PRALHNCPYKCIC-AADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQ 86
PR CP+ C C + CT L VPA + ++L N++Q L A L +
Sbjct: 21 PRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLTK 80
Query: 87 LRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLV 146
L L + NE+ ++ G + S L++ S N LR + L GL L +L + +N++
Sbjct: 81 LELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIE 140
Query: 147 HLDEHAFHGLRALSHLYLGCNEL-----ASFS-FDHLHGLSATHLLTLDLSSNRLGHISV 200
+ AF+GL +L L+L N L ++FS F L + + L L+ N + +
Sbjct: 141 FIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPA 200
Query: 201 PELAALPAFLKNGLYLHNNPLPCDCRLYHLLQ 232
L +P L LYL NP CDC + L+
Sbjct: 201 SMLRNMP--LLENLYLQGNPWTCDCEMRWFLE 230
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/63 (36%), Positives = 38/63 (60%), Gaps = 1/63 (1%)
Query: 293 GRSLRLYCNTSV-PAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFV 351
G +L+L C+ S P RI W P + ++ A S D I V A+G+L + +V ++ AG ++
Sbjct: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL 2220
Query: 352 CLA 354
C+A
Sbjct: 2221 CVA 2223
Score = 36.6 bits (83), Expect = 0.055
Identities = 21/66 (31%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 291 LVGRSLRLYCNTSVP-AMRIAWVSPQQELLRAP-GSRDGSIAVLADGSLAIGNVQEQHAG 348
L G +L CN + I WV P +L+AP D ++L+ G L I +++ +G
Sbjct: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
Query: 349 LFVCLA 354
L+ C+A
Sbjct: 552 LYQCIA 557
Score = 34.7 bits (78), Expect = 0.21
Identities = 17/63 (26%), Positives = 35/63 (55%), Gaps = 2/63 (3%)
Query: 293 GRSLRLYCNT-SVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFV 351
G S+ L CN ++P ++W+ P + ++ + + +L +G+L+I VQ +G +
Sbjct: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANTS-HVYMLPNGTLSIPKVQVSDSGYYR 650
Query: 352 CLA 354
C+A
Sbjct: 651 CVA 653
Score = 32.7 bits (73), Expect = 0.79
Identities = 17/54 (31%), Positives = 24/54 (44%)
Query: 302 TSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLAT 355
T P + W L P +R VL +G+L I VQ Q G ++C A+
Sbjct: 1878 TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTAS 1931
Score = 31.2 bits (69), Expect = 2.3
Identities = 19/78 (24%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 293 GRSLRLYCNT-SVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFV 351
G S+ ++C + P + WV +R G++ V +G+L I N+ + +G +
Sbjct: 2062 GLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYE 2121
Query: 352 CLATGPRLHHNQTHEYNV 369
C+A +T + NV
Sbjct: 2122 CVAANLVGSARRTVQLNV 2139
Score = 31.2 bits (69), Expect = 2.3
Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 8/115 (6%)
Query: 286 EHLYALVGRSLRLYCNTS-VPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQE 344
E + A+ G ++ L C+ + P + WV P L++ G + ADG L I +
Sbjct: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS-GQQLQRFYHKADGMLHISGLSS 2608
Query: 345 QHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVL 399
AG + C+A H + V + +PEA N + L+ G L L
Sbjct: 2609 VDAGAYRCVARNAAGHTERLVSLKVGL-----KPEA-NKQYHNLVSIINGETLKL 2657
Score = 31.2 bits (69), Expect = 2.3
Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 3/74 (4%)
Query: 284 PEEHLYALVGRSLRLYCNT-SVPAMRIAWVSPQQELLRA--PGSRDGSIAVLADGSLAIG 340
P +Y G +++L C +P I W P + L+A G+ + GSL I
Sbjct: 2739 PTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ 2798
Query: 341 NVQEQHAGLFVCLA 354
+ ++ AG + C+A
Sbjct: 2799 HATQRDAGFYKCMA 2812
Score = 30.4 bits (67), Expect = 3.9
Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 3/71 (4%)
Query: 305 PAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQT 364
P ++ W+SP +++ + + DG+L I Q +G + CL +T
Sbjct: 2374 PMPKVTWLSPTNKVIPTSSEK---YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKT 2430
Query: 365 HEYNVSVHFPR 375
+V+V P+
Sbjct: 2431 VWIHVNVQPPK 2441
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 82.8 bits (203), Expect = 7e-16
Identities = 69/214 (32%), Positives = 95/214 (44%), Gaps = 9/214 (4%)
Query: 10 LLCMLRVGL-GTPDSEGFPPRALHNCPYKCICAADL-LSCTGLGLQDVPAELPAATADLD 67
LLC L +GL G+ G P C C C D + C+G GL VP L A T LD
Sbjct: 7 LLCFLALGLLGSAGPSGAAPPL---CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALD 63
Query: 68 LSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRH 127
+S N + +L L L L N+L + L++L L +N L+ +
Sbjct: 64 ISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSE 123
Query: 128 DLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLT 187
+ GL AL+ L L N + + E +F GL L HL+L N L L L LT
Sbjct: 124 AIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALT 183
Query: 188 LDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
L L N++ S+P+ A L+LHNN +
Sbjct: 184 LAL--NKIS--SIPDFAFTNLSSLVVLHLHNNKI 213
Score = 49.7 bits (117), Expect = 6e-06
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 12/201 (5%)
Query: 52 LQDVPAELP---AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNA 108
L+ VP+E +A L L N + + L QLR L LD N L + N
Sbjct: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
Query: 109 SGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNE 168
L+ L L+ N + ++ L +L L L NN++ L +H F GL L L L N
Sbjct: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Query: 169 LASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLP-CDCRL 227
L F + L + L L SN + +P+ A L ++L++NPL
Sbjct: 237 LGEFP-QAIKALPS--LKELGFHSNSIS--VIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
Query: 228 YHLLQRWHQ---RGLSAVRDF 245
+H L H RG S V+ F
Sbjct: 292 FHNLSDLHSLVIRGASMVQQF 312
Score = 38.5 bits (88), Expect = 0.014
Identities = 40/150 (26%), Positives = 61/150 (40%), Gaps = 39/150 (26%)
Query: 45 LSCTGLGLQDVPAEL---PAATADLDLSHNALQRLRPGWLAPLFQ----LRALHLDHNEL 97
L+ TG + +P L LDLS+N ++ L P F L + L N++
Sbjct: 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL------PSFNGCHALEEISLQRNQI 377
Query: 98 DALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVH-LDEHAFHGL 156
+ G F LR+LDLS N L+H + AF L
Sbjct: 378 YQIKEGTFQGLISLRILDLSRN-------------------------LIHEIHSRAFATL 412
Query: 157 RALSHLYLGCNELASFSFDHLHGLSATHLL 186
+++L + NEL SF + L+GL+ L+
Sbjct: 413 GPITNLDVSFNELTSFPTEGLNGLNQLKLV 442
Score = 37.0 bits (84), Expect = 0.042
Identities = 33/120 (27%), Positives = 52/120 (43%), Gaps = 10/120 (8%)
Query: 62 ATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTL 121
A ++ L N + +++ G L LR L L N + + F + LD+S N L
Sbjct: 366 ALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNEL 425
Query: 122 RALGRHDLDGLGALEKLLLFNNRLVH-LDEHAFHGLRALSHLYL-------GCNELASFS 173
+ L+GL L+ L+ N +L L F LR+LS Y GC+ A+ +
Sbjct: 426 TSFPTEGLNGLNQLK--LVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLN 483
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 82.4 bits (202), Expect = 9e-16
Identities = 74/215 (34%), Positives = 95/215 (44%), Gaps = 35/215 (16%)
Query: 30 ALHNCPYKCICAADLLS--CTGLGLQDVPAELPAATADLDLSHNALQRLRPGW-LAPLFQ 86
AL CP+ C C + L C+GLGL VP ++PAAT L L +N L L P W A L
Sbjct: 35 ALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSAL-PSWAFANLSS 93
Query: 87 LRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLV 146
L+ L L +N LD L R +F + + L L L +N++R L R L L L L N L
Sbjct: 94 LQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLA 153
Query: 147 HLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAAL 206
L F GL AL L L N L +L L+ L L L
Sbjct: 154 QLPPGLFDGLLALRSLSLRSNRL-----QNLDRLTFEPLANLQL---------------- 192
Query: 207 PAFLKNGLYLHNNPLPCDCRL---YHLLQRWHQRG 238
L + +NP CDC L H ++ + RG
Sbjct: 193 -------LQVGDNPWECDCNLREFKHWMEWFSYRG 220
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 82.4 bits (202), Expect = 9e-16
Identities = 89/328 (27%), Positives = 136/328 (41%), Gaps = 51/328 (15%)
Query: 34 CPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLD 93
CP +C+C + C L L +P ++P T LDL N ++ + PG
Sbjct: 24 CPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREI-PG-------------- 67
Query: 94 HNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAF 153
F L L L++N +R + R+ +GL L L L+ N + LD+ F
Sbjct: 68 ---------SAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTF 118
Query: 154 HGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNG 213
GL +L HLY+ N+L + L L L L +N+L I + L + +
Sbjct: 119 KGLISLEHLYIHFNQLEMLQPETFGDL--LRLERLFLHNNKLSKIPAGSFSNLDSLKR-- 174
Query: 214 LYLHNNPLPCDCRLY---HLLQRWHQRG---LSAVRDFAREYVCLAFKVPASRVRFFQHS 267
L L +N L CDC L LLQ + Q G +A ++ R A V + V F
Sbjct: 175 LRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRA--VASVTVEEF--- 229
Query: 268 RVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTSV-PAMRIAWVSPQQELLRAPGSRD 326
NC S P + E + + + G ++ C P I W+ L +R
Sbjct: 230 ----NCQS-PRITFEPQDVEVPS--GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTR- 281
Query: 327 GSIAVLADGSLAIGNVQEQHAGLFVCLA 354
+ V DG+L I N +E G++ C+A
Sbjct: 282 --LNVFDDGTLMIRNTRESDQGVYQCMA 307
>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
Length = 341
Score = 80.9 bits (198), Expect = 3e-15
Identities = 57/164 (34%), Positives = 79/164 (48%), Gaps = 7/164 (4%)
Query: 33 NCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHL 92
+CP C C ++ C+ L VP +LP T +L L+HN + + PG+L +L+ L L
Sbjct: 80 SCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDL 139
Query: 93 DHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNN---RLVHLD 149
+N L L RG+F++A L LDLS N + L + L +N R VH
Sbjct: 140 HNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVH-- 197
Query: 150 EHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSN 193
AF GL L L L LA S + L GL L+TL + N
Sbjct: 198 PQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPG--LVTLQIGGN 239
>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
Length = 334
Score = 80.1 bits (196), Expect = 4e-15
Identities = 69/196 (35%), Positives = 84/196 (42%), Gaps = 29/196 (14%)
Query: 33 NCPYKCICA-ADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALH 91
+CP C C L SC+ L L VP L +LRAL
Sbjct: 42 DCPEVCTCVPGGLASCSALSLPAVPPGLS------------------------LRLRALL 77
Query: 92 LDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEH 151
LDHN + AL G F A L+ LDL N L ++ GLGAL+ L L N+L L
Sbjct: 78 LDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPG 137
Query: 152 AFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLK 211
F LRAL +L L N LA L L L +L L N L ++ L LPA
Sbjct: 138 TFAPLRALRNLSLAGNRLARLEPAALGALPL--LRSLSLQDNELAALAPGLLGRLPAL-- 193
Query: 212 NGLYLHNNPLPCDCRL 227
+ L+L NP C C L
Sbjct: 194 DALHLRGNPWGCGCAL 209
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 80.1 bits (196), Expect = 4e-15
Identities = 64/173 (36%), Positives = 83/173 (47%), Gaps = 27/173 (15%)
Query: 59 LPAATAD-------LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGL 111
LP A D L L HNAL+ + L L+ L L+ N+LD L +F N L
Sbjct: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
Query: 112 RLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELAS 171
+LLDLS N L L + L LE+LLL +NRLV LD + L AL+ L N + S
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
Query: 172 F---SFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
+FD L LS +L LS N L AFL + L+LH++ L
Sbjct: 233 IAPGAFDRLPNLS-----SLTLSRNHL------------AFLPSALFLHSHNL 268
Score = 43.1 bits (100), Expect = 6e-04
Identities = 38/112 (33%), Positives = 53/112 (47%), Gaps = 1/112 (0%)
Query: 65 DLDLSHNALQRLRPGWLAPLFQLRALHLDHN-ELDALGRGVFVNASGLRLLDLSSNTLRA 123
+L L+ L+ L L +LR L + + L AL +G F L++L L SN L A
Sbjct: 294 ELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTA 353
Query: 124 LGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFD 175
L L GLG L ++ L NRL L F L +L + L N+L + D
Sbjct: 354 LPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGD 405
Score = 43.1 bits (100), Expect = 6e-04
Identities = 34/95 (35%), Positives = 44/95 (46%)
Query: 73 LQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGL 132
L L G L +L+ L L N L AL G+ LR + L N LRAL R L
Sbjct: 327 LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNL 386
Query: 133 GALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCN 167
+LE + L +N+L L F L L+ + LG N
Sbjct: 387 SSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 35.8 bits (81), Expect = 0.094
Identities = 64/247 (25%), Positives = 88/247 (35%), Gaps = 71/247 (28%)
Query: 5 VLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICA-ADLLSCTGLGLQDVPAELPAAT 63
+L GTLLC + LG ++ FP CP C C D C+G + + A
Sbjct: 1 MLRGTLLCAV---LGLLRAQPFP------CPPACKCVFRDAAQCSGGDVARISA------ 45
Query: 64 ADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGV-----FVNASGLRLLDLSS 118
L L N L H L +GRGV F + L+ L +S
Sbjct: 46 --LGLPTN--------------------LTHILLFGMGRGVLQSQSFSGMTVLQRLMISD 83
Query: 119 NTLRALGRHDLDGLGALEKLLLFNNRLVHL------------------------DEHAFH 154
+ + A+ L L+ L L N++ HL D++ F
Sbjct: 84 SHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQ 143
Query: 155 GLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGL 214
L L L L N+L L +L LDLS N L H+ L A + L
Sbjct: 144 KLVNLQELALNQNQLDFLPASLFTNLE--NLKLLDLSGNNLTHLPKGLLGAQAKLER--L 199
Query: 215 YLHNNPL 221
LH+N L
Sbjct: 200 LLHSNRL 206
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 79.7 bits (195), Expect = 6e-15
Identities = 106/409 (25%), Positives = 152/409 (37%), Gaps = 76/409 (18%)
Query: 34 CPYKCICAADLLS------CTGLGLQDVPAELPAATA----------------------- 64
CP +C+C +LS C GL VP + T
Sbjct: 20 CPKRCVC--QILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSL 77
Query: 65 -DLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRA 123
DL LS N + + P A L LRALHL+ N L + +F S L L L++N L
Sbjct: 78 VDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTL 137
Query: 124 LGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASF---SFDHLHGL 180
+ D + ALE+L L N L + A + +L L L N + + +F HLH +
Sbjct: 138 ISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKM 197
Query: 181 SATHLLTLDLSSNRLGHISVPELAALPAFLKN---------GLYLHNNPLPCDCRLYHLL 231
+ LD++SN+L + L L L NPL C+C L L
Sbjct: 198 T-----RLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWL- 251
Query: 232 QRWHQRGLSAVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYAL 291
R LS D C + P R+F E P + R + L
Sbjct: 252 -----RRLSREDDLE---TCAS--PPLLTGRYFWSIPEEEFLCEPPL--ITRHTHEMRVL 299
Query: 292 VGRSLRLYCNT-SVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLF 350
G+ L C P I W+SP+ +L+ S V +G+L I + G F
Sbjct: 300 EGQRATLRCKARGDPEPAIHWISPEGKLI----SNATRSLVYDNGTLDILITTVKDTGAF 355
Query: 351 VCLATGPRLHHNQ---------THEYNVSVHFPRPEPEAFNTGFTTLLG 390
C+A+ P Q H N + H P+P + + +T G
Sbjct: 356 TCIASNPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSG 404
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 79.3 bits (194), Expect = 7e-15
Identities = 56/201 (27%), Positives = 93/201 (46%), Gaps = 9/201 (4%)
Query: 34 CPYKCICAADL-LSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHL 92
CP +C C + CT L +P +P ++L +N+L RL + L +L L L
Sbjct: 29 CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLML 88
Query: 93 DHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHA 152
N + + F + L++L +S N +R L + GL +L +L + +N + ++
Sbjct: 89 HSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEV 148
Query: 153 FHGLRALSHLYLGCNELASF------SFDHLHGLSATHLLTLDLSSNRLGHISVPELAAL 206
F+GL L ++L N+L S +L + + L LS N L + ++ +
Sbjct: 149 FYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYM 208
Query: 207 PAFLKNGLYLHNNPLPCDCRL 227
P + LYLH NP CDC L
Sbjct: 209 PDL--DSLYLHGNPWTCDCHL 227
Score = 37.7 bits (86), Expect = 0.025
Identities = 23/78 (29%), Positives = 32/78 (41%), Gaps = 3/78 (3%)
Query: 283 RPEEHLYALVGRSLRLYCNT-SVPAMRIAWVSPQQELLRAPGSR--DGSIAVLADGSLAI 339
RP + G + +L+C VP I W P LL GS + G+L I
Sbjct: 2533 RPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVI 2592
Query: 340 GNVQEQHAGLFVCLATGP 357
N Q +G++ C A P
Sbjct: 2593 QNPQTSDSGIYKCTAKNP 2610
Score = 37.4 bits (85), Expect = 0.032
Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 6/111 (5%)
Query: 248 EYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTSV-PA 306
+Y+C AS + H V + S P LER + + G ++ L C P+
Sbjct: 1720 QYLC-----SASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
Query: 307 MRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGP 357
+ W+ Q ++ V DG+L + N+ G + C+A+ P
Sbjct: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNP 1825
Score = 36.2 bits (82), Expect = 0.072
Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 4/72 (5%)
Query: 287 HLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQ 345
H +G +L L C+ T +P I+WV P +L SRD VL +G+L I V +
Sbjct: 582 HHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQ-SSRDKK--VLNNGTLRILQVTPK 638
Query: 346 HAGLFVCLATGP 357
G + C+A P
Sbjct: 639 DQGYYRCVAANP 650
Score = 35.4 bits (80), Expect = 0.12
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Query: 293 GRSLRLYCN-TSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFV 351
G L L C+ T P +I W P + ++ I V +GSL IG+V E+ +G+++
Sbjct: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYL 2015
Query: 352 CLA 354
C+A
Sbjct: 2016 CVA 2018
Score = 33.9 bits (76), Expect = 0.36
Identities = 28/126 (22%), Positives = 49/126 (38%), Gaps = 8/126 (6%)
Query: 275 SAPALGLERPEEHLYALVGRSLRLYCNTS-VPAMRIAWVSPQQELLRAPGSRDGSIAVLA 333
+AP + LE+ + + G SL+L C P + WV ++ + + + +
Sbjct: 1839 AAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFS 1898
Query: 334 DGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEA-------FNTGFT 386
+G+L I N+ G + C+AT + + P EA N G
Sbjct: 1899 NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK 1958
Query: 387 TLLGCA 392
LL C+
Sbjct: 1959 LLLNCS 1964
Score = 32.0 bits (71), Expect = 1.4
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 5/52 (9%)
Query: 305 PAMRIAWVSPQQELLRAP--GSRDGSIAVLADGSLAIGNVQEQHAGLFVCLA 354
P+ + W+ P L AP GSR I V +G+L I NV+ + F+C+A
Sbjct: 2267 PSPEVMWIMPDNIFLTAPYYGSR---ITVHKNGTLEIRNVRLSDSADFICVA 2315
Score = 30.8 bits (68), Expect = 3.0
Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 5/92 (5%)
Query: 302 TSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHH 361
T P +I W+ P +++ R A+GSL I V+ +G +VC+A P
Sbjct: 2166 TGDPKPKIFWLLPSNDMISFSIDR---YTFHANGSLTINKVKLLDSGEYVCVARNP--SG 2220
Query: 362 NQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAV 393
+ T Y + V P T T + AV
Sbjct: 2221 DDTKMYKLDVVSKPPLINGLYTNRTVIKATAV 2252
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 78.6 bits (192), Expect = 1e-14
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 2/134 (1%)
Query: 65 DLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124
+L L HN +++L L QL L LDHN+L + G F+ + + +++LS N LR L
Sbjct: 356 ELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNL 415
Query: 125 GRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATH 184
GLG L L L + L + H F GL L L+L N L L GL+
Sbjct: 416 PEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA--E 473
Query: 185 LLTLDLSSNRLGHI 198
LL LDL+SN+L H+
Sbjct: 474 LLELDLTSNQLTHL 487
Score = 75.1 bits (183), Expect = 1e-13
Identities = 82/245 (33%), Positives = 99/245 (40%), Gaps = 39/245 (15%)
Query: 10 LLCMLRVGLGTPDSEGFPPRALHN-----CPYKCICA----ADLLS--CTGLGLQDVPAE 58
LL + V LG EG P CP C+C+ AD LS C+ L +P
Sbjct: 50 LLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDG 109
Query: 59 LPAATADLDLSHNALQRLRP-------------------GWLAP-----LFQLRALHLDH 94
+P T L L N L + P G L P L L LHL+
Sbjct: 110 VPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLER 169
Query: 95 NELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFH 154
N+L +L G F + L L LS+N L L +GLG+L L L N L L + AF
Sbjct: 170 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 229
Query: 155 GLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGL 214
GL +L L L N LA GL+ L LDLS N L I LP K L
Sbjct: 230 GLGSLRELVLAGNRLAYLQPALFSGLA--ELRELDLSRNALRAIKANVFVQLPRLQK--L 285
Query: 215 YLHNN 219
YL N
Sbjct: 286 YLDRN 290
Score = 69.7 bits (169), Expect = 6e-12
Identities = 45/129 (34%), Positives = 61/129 (47%)
Query: 61 AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT 120
A +LDLS NAL+ ++ L +L+ L+LD N + A+ G F+ LR LDLS N
Sbjct: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
Query: 121 LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL 180
+ L GL L L L +N + L F L L L LG N + + GL
Sbjct: 316 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
Query: 181 SATHLLTLD 189
+LTLD
Sbjct: 376 GQLEVLTLD 384
Score = 68.6 bits (166), Expect = 1e-11
Identities = 66/201 (32%), Positives = 84/201 (41%), Gaps = 32/201 (15%)
Query: 64 ADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRA 123
A ++LS N L+ L L +L +LHL+ + L + F SGLR L L N L
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462
Query: 124 LGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSAT 183
+ L GL L +L L +N+L HL F GL L +L L N LA D L L
Sbjct: 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-- 520
Query: 184 HLLTLDLSSNRLGHISVPELAALPAF----LKNG--------------LYLHNNPLPCDC 225
LD+S NRL + LA L L+N L+L NP C C
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 580
Query: 226 RLYHLLQRWHQRGLSAVRDFA 246
L A+RDFA
Sbjct: 581 ------------PLKALRDFA 589
Score = 63.2 bits (152), Expect = 5e-10
Identities = 51/156 (32%), Positives = 69/156 (44%), Gaps = 4/156 (2%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
LDLSHN + L L LR L L HN + +L F + L L L N +R L
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
+GLG LE L L +N+L + AF GL ++ + L N L + GL H
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH- 427
Query: 186 LTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPL 221
+L L + LG I L + L+L +N L
Sbjct: 428 -SLHLEGSCLGRIRPHTFTGLSGLRR--LFLKDNGL 460
Score = 60.5 bits (145), Expect = 4e-09
Identities = 46/133 (34%), Positives = 63/133 (47%), Gaps = 2/133 (1%)
Query: 66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALG 125
L L N + + PG L LR L L HN + L F GLR+L LS N + +L
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344
Query: 126 RHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHL 185
L LE+L L +NR+ L E +F GL L L L N+L GL T++
Sbjct: 345 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL--TNV 402
Query: 186 LTLDLSSNRLGHI 198
++LS N L ++
Sbjct: 403 AVMNLSGNCLRNL 415
Score = 57.0 bits (136), Expect = 4e-08
Identities = 49/138 (35%), Positives = 65/138 (47%), Gaps = 8/138 (5%)
Query: 65 DLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124
+L L+ N L L+P + L +LR L L N L A+ VFV L+ L L N + A+
Sbjct: 236 ELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAV 295
Query: 125 GRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASF---SFDHLHGLS 181
GL AL L L +NR+ L E F GL L L L N +AS +F LH L
Sbjct: 296 APGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 355
Query: 182 ATHLLTLDLSSNRLGHIS 199
L L NR+ ++
Sbjct: 356 -----ELQLGHNRIRQLA 368
Score = 55.8 bits (133), Expect = 9e-08
Identities = 46/124 (37%), Positives = 58/124 (46%)
Query: 65 DLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124
DL+L N+L L L LR L L N L L +F + LR LDLS N LRA+
Sbjct: 212 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 271
Query: 125 GRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATH 184
+ L L+KL L N + + AF GL+AL L L N +A D GL
Sbjct: 272 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 331
Query: 185 LLTL 188
+L L
Sbjct: 332 VLRL 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,819,079
Number of Sequences: 37866
Number of extensions: 1071945
Number of successful extensions: 4123
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 2556
Number of HSP's gapped (non-prelim): 879
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.