Guide to the Human Genome
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Search of human proteins with 38201621

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
isoform 1 [Homo sapiens]
         (1599 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ...  3190   0.0  
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ...  3190   0.0  
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ...  3010   0.0  
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ...  2849   0.0  
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ...  2784   0.0  
gi|10092601 eukaryotic translation initiation factor 4 gamma, 3 ...  1273   0.0  
gi|110630018 eukaryotic translation initiation factor 4 gamma, 2...   196   2e-49
gi|4503539 eukaryotic translation initiation factor 4 gamma, 2 i...   196   2e-49
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   100   1e-20
gi|163965366 nascent polypeptide-associated complex alpha subuni...    94   1e-18
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    85   5e-16
gi|150170670 piccolo isoform 2 [Homo sapiens]                          84   1e-15
gi|150378539 piccolo isoform 1 [Homo sapiens]                          84   1e-15
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   84   1e-15
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   84   1e-15
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   84   1e-15
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    84   1e-15
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    83   2e-15
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    82   4e-15
gi|112421108 capicua homolog [Homo sapiens]                            82   4e-15
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    81   7e-15
gi|33386693 poly(A) binding protein interacting protein 1 isofor...    81   9e-15
gi|17511255 poly(A) binding protein interacting protein 1 isofor...    81   9e-15
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              79   3e-14
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    79   4e-14
gi|169212085 PREDICTED: similar to poly(A) binding protein inter...    78   8e-14
gi|239752553 PREDICTED: similar to poly(A) binding protein inter...    78   8e-14
gi|89041275 PREDICTED: similar to poly(A) binding protein intera...    78   8e-14
gi|34452730 poly(A) binding protein interacting protein 1 isofor...    77   1e-13
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    77   1e-13

>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
            isoform 1 [Homo sapiens]
          Length = 1599

 Score = 3190 bits (8271), Expect = 0.0
 Identities = 1599/1599 (100%), Positives = 1599/1599 (100%)

Query: 1    MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60
            MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
Sbjct: 1    MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60

Query: 61   SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY 120
            SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
Sbjct: 61   SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY 120

Query: 121  PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTI 180
            PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTI
Sbjct: 121  PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTI 180

Query: 181  RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI 240
            RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
Sbjct: 181  RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI 240

Query: 241  IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES 300
            IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
Sbjct: 241  IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES 300

Query: 301  TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE 360
            TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
Sbjct: 301  TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE 360

Query: 361  PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE 420
            PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
Sbjct: 361  PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE 420

Query: 421  PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG 480
            PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
Sbjct: 421  PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG 480

Query: 481  EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA 540
            EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
Sbjct: 481  EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA 540

Query: 541  VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ 600
            VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
Sbjct: 541  VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ 600

Query: 601  WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI 660
            WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
Sbjct: 601  WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI 660

Query: 661  NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL 720
            NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
Sbjct: 661  NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL 720

Query: 721  MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM 780
            MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
Sbjct: 721  MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM 780

Query: 781  KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR 840
            KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
Sbjct: 781  KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR 840

Query: 841  KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK 900
            KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
Sbjct: 841  KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK 900

Query: 901  FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN 960
            FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
Sbjct: 901  FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN 960

Query: 961  QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV 1020
            QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
Sbjct: 961  QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV 1020

Query: 1021 QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS 1080
            QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
Sbjct: 1021 QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS 1080

Query: 1081 NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV 1140
            NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
Sbjct: 1081 NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV 1140

Query: 1141 VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ 1200
            VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
Sbjct: 1141 VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ 1200

Query: 1201 PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK 1260
            PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
Sbjct: 1201 PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK 1260

Query: 1261 EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY 1320
            EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
Sbjct: 1261 EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY 1320

Query: 1321 EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL 1380
            EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
Sbjct: 1321 EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL 1380

Query: 1381 GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS 1440
            GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
Sbjct: 1381 GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS 1440

Query: 1441 EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD 1500
            EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
Sbjct: 1441 EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD 1500

Query: 1501 VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF 1560
            VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
Sbjct: 1501 VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF 1560

Query: 1561 YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1599
            YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Sbjct: 1561 YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1599


>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
            isoform 1 [Homo sapiens]
          Length = 1599

 Score = 3190 bits (8271), Expect = 0.0
 Identities = 1599/1599 (100%), Positives = 1599/1599 (100%)

Query: 1    MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60
            MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
Sbjct: 1    MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60

Query: 61   SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY 120
            SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
Sbjct: 61   SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY 120

Query: 121  PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTI 180
            PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTI
Sbjct: 121  PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTI 180

Query: 181  RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI 240
            RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
Sbjct: 181  RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI 240

Query: 241  IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES 300
            IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
Sbjct: 241  IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES 300

Query: 301  TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE 360
            TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
Sbjct: 301  TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE 360

Query: 361  PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE 420
            PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
Sbjct: 361  PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE 420

Query: 421  PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG 480
            PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
Sbjct: 421  PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG 480

Query: 481  EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA 540
            EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
Sbjct: 481  EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA 540

Query: 541  VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ 600
            VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
Sbjct: 541  VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ 600

Query: 601  WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI 660
            WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
Sbjct: 601  WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI 660

Query: 661  NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL 720
            NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
Sbjct: 661  NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL 720

Query: 721  MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM 780
            MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
Sbjct: 721  MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM 780

Query: 781  KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR 840
            KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
Sbjct: 781  KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR 840

Query: 841  KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK 900
            KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
Sbjct: 841  KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK 900

Query: 901  FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN 960
            FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
Sbjct: 901  FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN 960

Query: 961  QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV 1020
            QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
Sbjct: 961  QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV 1020

Query: 1021 QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS 1080
            QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
Sbjct: 1021 QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS 1080

Query: 1081 NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV 1140
            NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
Sbjct: 1081 NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV 1140

Query: 1141 VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ 1200
            VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
Sbjct: 1141 VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ 1200

Query: 1201 PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK 1260
            PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
Sbjct: 1201 PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK 1260

Query: 1261 EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY 1320
            EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
Sbjct: 1261 EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY 1320

Query: 1321 EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL 1380
            EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
Sbjct: 1321 EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL 1380

Query: 1381 GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS 1440
            GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
Sbjct: 1381 GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS 1440

Query: 1441 EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD 1500
            EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
Sbjct: 1441 EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD 1500

Query: 1501 VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF 1560
            VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
Sbjct: 1501 VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF 1560

Query: 1561 YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1599
            YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Sbjct: 1561 YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1599


>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
            isoform 2 [Homo sapiens]
          Length = 1512

 Score = 3010 bits (7804), Expect = 0.0
 Identities = 1512/1512 (100%), Positives = 1512/1512 (100%)

Query: 88   MMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYP 147
            MMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYP
Sbjct: 1    MMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYP 60

Query: 148  AQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPT 207
            AQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPT
Sbjct: 61   AQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPT 120

Query: 208  PPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPS 267
            PPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPS
Sbjct: 121  PPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPS 180

Query: 268  PSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEV 327
            PSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEV
Sbjct: 181  PSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEV 240

Query: 328  EVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACP 387
            EVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACP
Sbjct: 241  EVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACP 300

Query: 388  SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 447
            SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS
Sbjct: 301  SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 360

Query: 448  ATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQV 507
            ATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQV
Sbjct: 361  ATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQV 420

Query: 508  AVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRP 567
            AVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRP
Sbjct: 421  AVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRP 480

Query: 568  EEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASM 627
            EEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASM
Sbjct: 481  EEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASM 540

Query: 628  QKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGG 687
            QKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGG
Sbjct: 541  QKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGG 600

Query: 688  PGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDR 747
            PGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDR
Sbjct: 601  PGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDR 660

Query: 748  GEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAIS 807
            GEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAIS
Sbjct: 661  GEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAIS 720

Query: 808  EPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKE 867
            EPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKE
Sbjct: 721  EPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKE 780

Query: 868  MDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNH 927
            MDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNH
Sbjct: 781  MDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNH 840

Query: 928  DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRG 987
            DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRG
Sbjct: 841  DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRG 900

Query: 988  SNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLV 1047
            SNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLV
Sbjct: 901  SNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLV 960

Query: 1048 DDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSD 1107
            DDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSD
Sbjct: 961  DDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSD 1020

Query: 1108 AASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERG 1167
            AASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERG
Sbjct: 1021 AASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERG 1080

Query: 1168 GDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAAL 1227
            GDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAAL
Sbjct: 1081 GDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAAL 1140

Query: 1228 PPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTL 1287
            PPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTL
Sbjct: 1141 PPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTL 1200

Query: 1288 ERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPI 1347
            ERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPI
Sbjct: 1201 ERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPI 1260

Query: 1348 LQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFL 1407
            LQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFL
Sbjct: 1261 LQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFL 1320

Query: 1408 PEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEAN 1467
            PEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEAN
Sbjct: 1321 PEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEAN 1380

Query: 1468 LSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYA 1527
            LSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYA
Sbjct: 1381 LSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYA 1440

Query: 1528 LQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK 1587
            LQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK
Sbjct: 1441 LQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK 1500

Query: 1588 WLREAEEESDHN 1599
            WLREAEEESDHN
Sbjct: 1501 WLREAEEESDHN 1512



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 81/379 (21%), Positives = 126/379 (33%), Gaps = 61/379 (16%)

Query: 5   PQSTGPPPAPSPGLPQPAFP-------PGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQ 57
           P S  P P+PSP L   + P       PG T   +     + + +TP   R+   P R  
Sbjct: 172 PSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTI---QMSVEESTPIS-RETGEPYRLS 227

Query: 58  P-PSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYI---PGQGRSTY 113
           P P+  A  +         P        S+    P Q   P +     I    G   S  
Sbjct: 228 PEPTPLAEPILEVEVTLSKPVPE-----SEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 282

Query: 114 VVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAP 173
           + P  +   +   P   P  SP           P    ++   G AP+P  ++  P    
Sbjct: 283 LEPEVESSPELAPPPACPSESPVPIA-------PTAQPEELLNG-APSPPAVDLSP---- 330

Query: 174 KRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPD 233
                   + +P +  K++T  +       + PT P       P A     Q   +   +
Sbjct: 331 --------VSEPEEQAKEVTASM-------APPTIPSATPATAPSATSPA-QEEEMEEEE 374

Query: 234 DRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSP-SPVLEPGSEPNLAVLSIPGDTMTT 292
           +  +G   A   G    E    E  P   +P P+  S  LE  +   +AV S+P      
Sbjct: 375 EEEEGE--AGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAV-SVPKRRRKI 431

Query: 293 IQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSS---SPLQAPT 349
            +++ +E+       G+      E  P    +       S P PESE S     P +A  
Sbjct: 432 KELNKKEA------VGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADE 485

Query: 350 PLASHTVEIHEPNGMVPSE 368
              S   +IH    + P E
Sbjct: 486 TWDSKEDKIHNAENIQPGE 504


>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
            isoform 3 [Homo sapiens]
          Length = 1435

 Score = 2849 bits (7386), Expect = 0.0
 Identities = 1435/1435 (100%), Positives = 1435/1435 (100%)

Query: 165  MNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETP 224
            MNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETP
Sbjct: 1    MNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETP 60

Query: 225  QVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLS 284
            QVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLS
Sbjct: 61   QVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLS 120

Query: 285  IPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSP 344
            IPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSP
Sbjct: 121  IPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSP 180

Query: 345  LQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELL 404
            LQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELL
Sbjct: 181  LQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELL 240

Query: 405  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 464
            NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE
Sbjct: 241  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 300

Query: 465  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK 524
            EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK
Sbjct: 301  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK 360

Query: 525  EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNA 584
            EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNA
Sbjct: 361  EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNA 420

Query: 585  ENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKA 644
            ENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKA
Sbjct: 421  ENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKA 480

Query: 645  NKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRS 704
            NKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRS
Sbjct: 481  NKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRS 540

Query: 705  QQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRV 764
            QQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRV
Sbjct: 541  QQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRV 600

Query: 765  RSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMA 824
            RSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMA
Sbjct: 601  RSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMA 660

Query: 825  LKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEEL 884
            LKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEEL
Sbjct: 661  LKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEEL 720

Query: 885  EEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGK 944
            EEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGK
Sbjct: 721  EEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGK 780

Query: 945  DLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQ 1004
            DLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQ
Sbjct: 781  DLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQ 840

Query: 1005 IHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPI 1064
            IHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPI
Sbjct: 841  IHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPI 900

Query: 1065 DTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFS 1124
            DTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFS
Sbjct: 901  DTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFS 960

Query: 1125 ALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKR 1184
            ALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKR
Sbjct: 961  ALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKR 1020

Query: 1185 SFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEK 1244
            SFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEK
Sbjct: 1021 SFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEK 1080

Query: 1245 KSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQL 1304
            KSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQL
Sbjct: 1081 KSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQL 1140

Query: 1305 LCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITK 1364
            LCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITK
Sbjct: 1141 LCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITK 1200

Query: 1365 PLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEY 1424
            PLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEY
Sbjct: 1201 PLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEY 1260

Query: 1425 TLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMT 1484
            TLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMT
Sbjct: 1261 TLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMT 1320

Query: 1485 AVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRM 1544
            AVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRM
Sbjct: 1321 AVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRM 1380

Query: 1545 FFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1599
            FFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Sbjct: 1381 FFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1435



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 81/379 (21%), Positives = 126/379 (33%), Gaps = 61/379 (16%)

Query: 5   PQSTGPPPAPSPGLPQPAFP-------PGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQ 57
           P S  P P+PSP L   + P       PG T   +     + + +TP   R+   P R  
Sbjct: 95  PSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTI---QMSVEESTPIS-RETGEPYRLS 150

Query: 58  P-PSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYI---PGQGRSTY 113
           P P+  A  +         P        S+    P Q   P +     I    G   S  
Sbjct: 151 PEPTPLAEPILEVEVTLSKPVPE-----SEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 205

Query: 114 VVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAP 173
           + P  +   +   P   P  SP           P    ++   G AP+P  ++  P    
Sbjct: 206 LEPEVESSPELAPPPACPSESPVPIA-------PTAQPEELLNG-APSPPAVDLSP---- 253

Query: 174 KRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPD 233
                   + +P +  K++T  +       + PT P       P A     Q   +   +
Sbjct: 254 --------VSEPEEQAKEVTASM-------APPTIPSATPATAPSATSPA-QEEEMEEEE 297

Query: 234 DRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSP-SPVLEPGSEPNLAVLSIPGDTMTT 292
           +  +G   A   G    E    E  P   +P P+  S  LE  +   +AV S+P      
Sbjct: 298 EEEEGE--AGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAV-SVPKRRRKI 354

Query: 293 IQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSS---SPLQAPT 349
            +++ +E+       G+      E  P    +       S P PESE S     P +A  
Sbjct: 355 KELNKKEA------VGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADE 408

Query: 350 PLASHTVEIHEPNGMVPSE 368
              S   +IH    + P E
Sbjct: 409 TWDSKEDKIHNAENIQPGE 427


>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
            isoform 4 [Homo sapiens]
          Length = 1403

 Score = 2784 bits (7218), Expect = 0.0
 Identities = 1403/1403 (100%), Positives = 1403/1403 (100%)

Query: 197  MSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSE 256
            MSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSE
Sbjct: 1    MSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSE 60

Query: 257  SQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPE 316
            SQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPE
Sbjct: 61   SQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPE 120

Query: 317  PTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVES 376
            PTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVES
Sbjct: 121  PTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVES 180

Query: 377  SPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPT 436
            SPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPT
Sbjct: 181  SPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPT 240

Query: 437  IPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLS 496
            IPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLS
Sbjct: 241  IPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLS 300

Query: 497  QNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGP 556
            QNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGP
Sbjct: 301  QNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGP 360

Query: 557  ESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREF 616
            ESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREF
Sbjct: 361  ESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREF 420

Query: 617  LLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRT 676
            LLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRT
Sbjct: 421  LLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRT 480

Query: 677  TLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKP 736
            TLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKP
Sbjct: 481  TLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKP 540

Query: 737  SSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKG 796
            SSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKG
Sbjct: 541  SSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKG 600

Query: 797  VIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKD 856
            VIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKD
Sbjct: 601  VIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKD 660

Query: 857  DDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIM 916
            DDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIM
Sbjct: 661  DDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIM 720

Query: 917  HDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIR 976
            HDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIR
Sbjct: 721  HDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIR 780

Query: 977  FMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPP 1036
            FMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPP
Sbjct: 781  FMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPP 840

Query: 1037 GPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKG 1096
            GPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKG
Sbjct: 841  GPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKG 900

Query: 1097 SSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGD 1156
            SSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGD
Sbjct: 901  SSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGD 960

Query: 1157 RGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDR 1216
            RGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDR
Sbjct: 961  RGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDR 1020

Query: 1217 GRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLF 1276
            GRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLF
Sbjct: 1021 GRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLF 1080

Query: 1277 IFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHV 1336
            IFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHV
Sbjct: 1081 IFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHV 1140

Query: 1337 WLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLW 1396
            WLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLW
Sbjct: 1141 WLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLW 1200

Query: 1397 REAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSS 1456
            REAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSS
Sbjct: 1201 REAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSS 1260

Query: 1457 NQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC 1516
            NQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC
Sbjct: 1261 NQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC 1320

Query: 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKG 1576
            DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKG
Sbjct: 1321 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKG 1380

Query: 1577 VALKSVTAFFKWLREAEEESDHN 1599
            VALKSVTAFFKWLREAEEESDHN
Sbjct: 1381 VALKSVTAFFKWLREAEEESDHN 1403



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 81/379 (21%), Positives = 126/379 (33%), Gaps = 61/379 (16%)

Query: 5   PQSTGPPPAPSPGLPQPAFP-------PGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQ 57
           P S  P P+PSP L   + P       PG T   +     + + +TP   R+   P R  
Sbjct: 63  PSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTI---QMSVEESTPIS-RETGEPYRLS 118

Query: 58  P-PSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYI---PGQGRSTY 113
           P P+  A  +         P        S+    P Q   P +     I    G   S  
Sbjct: 119 PEPTPLAEPILEVEVTLSKPVPE-----SEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 173

Query: 114 VVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAP 173
           + P  +   +   P   P  SP           P    ++   G AP+P  ++  P    
Sbjct: 174 LEPEVESSPELAPPPACPSESPVPIA-------PTAQPEELLNG-APSPPAVDLSP---- 221

Query: 174 KRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPD 233
                   + +P +  K++T  +       + PT P       P A     Q   +   +
Sbjct: 222 --------VSEPEEQAKEVTASM-------APPTIPSATPATAPSATSPA-QEEEMEEEE 265

Query: 234 DRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSP-SPVLEPGSEPNLAVLSIPGDTMTT 292
           +  +G   A   G    E    E  P   +P P+  S  LE  +   +AV S+P      
Sbjct: 266 EEEEGE--AGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAV-SVPKRRRKI 322

Query: 293 IQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSS---SPLQAPT 349
            +++ +E+       G+      E  P    +       S P PESE S     P +A  
Sbjct: 323 KELNKKEA------VGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADE 376

Query: 350 PLASHTVEIHEPNGMVPSE 368
              S   +IH    + P E
Sbjct: 377 TWDSKEDKIHNAENIQPGE 395


>gi|10092601 eukaryotic translation initiation factor 4 gamma, 3 [Homo
            sapiens]
          Length = 1585

 Score = 1273 bits (3294), Expect = 0.0
 Identities = 808/1669 (48%), Positives = 1006/1669 (60%), Gaps = 194/1669 (11%)

Query: 41   MNTPSQPRQHFYPS-RAQPPSSAASRVQSAAPARPG---PAAHVYPAGSQVMMIPS-QIS 95
            MN+  Q R  F+   + QPP   A+   S+   RPG   P A VY A   +MM+    + 
Sbjct: 1    MNSQPQTRSPFFQRPQIQPPR--ATIPNSSPSIRPGAQTPTA-VYQANQHIMMVNHLPMP 57

Query: 96   YPASQGAYYIPGQGRST---YVVPTQQYPVQPGAPG-FYPGASPTEF-GTYAGAYYPAQG 150
            YP  QG  Y   Q R +   YV P QQYPVQP  PG FYPG  P +F   Y   +YP+Q 
Sbjct: 58   YPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQP 117

Query: 151  VQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGA---------- 200
            V Q    + P      QPP    KRE+KTIRIRDPNQGGKDITEEIMSG           
Sbjct: 118  VYQSAPIIVPT---QQQPPPA--KREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIG 172

Query: 201  RTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPS 260
            R  STPTPPQ    L  Q    +P V   V      + A +A    +        E +P 
Sbjct: 173  RPTSTPTPPQQ---LPSQVPEHSPVVYGTV------ESAHLAASTPVTAASDQKQEEKPK 223

Query: 261  SPSPTPSPSPVL----------------EPGSEPNLAVLSIPGD--TMTTIQMSVEESTP 302
                  SPSPVL                E  +  ++A L +P    T++++  S   +  
Sbjct: 224  PDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPT 283

Query: 303  ISRETGEPYRL----------SPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPT--- 349
             S  + +P             SP    +  P L      S P+P +E      + P    
Sbjct: 284  SSALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVA 343

Query: 350  ----PLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLN 405
                PL S T  I+E NG+  SE L    ES  E+      P    + I      E  L 
Sbjct: 344  PNDIPLVSSTNLINEINGV--SEKLSA-TESIVEIVKQEVLPLTLELEILENPPEEMKLE 400

Query: 406  GAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQ----EEEMEEEE 461
              P+P    ++P + P       T   +PP  P   PA A + +SP+     +  +EE+E
Sbjct: 401  CIPAP----ITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITVQRVLEEDE 456

Query: 462  E------EEEGEAGEAGEAESEKGGEELLPPES-----TPIPANLSQNLEAAAATQVAVS 510
                   E+  E     E E++   EE+L  ++     +P+PA            Q+A++
Sbjct: 457  SIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPA------------QIAIT 504

Query: 511  VPKRRRKIKELNK--KEAVGDLLDAFKEANPAVPEVENQPPAGSNPG--PESEGSGVPPR 566
            VPK  +K K+  +  +E +   L+   E   ++ +V        + G  PE + S +  +
Sbjct: 505  VPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLK-K 563

Query: 567  PEEADETWDSKEDKIHNAENIQPGEQ---------------KYEYKSDQWKPLNLEEKKR 611
             +  +E  +  E   + AE++  GE                 + +K + WKP + E KK+
Sbjct: 564  VKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQ 623

Query: 612  YDREFLLGFQFIFASMQKPEGLPHISDVVLDKAN--KTPLRPLDPTRLQGINCGPDFTPS 669
            YDREFLL FQF+ A +QKPEGLP ISDVVLDK N  K P+R LDP  L     GPDFTP+
Sbjct: 624  YDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPR---GPDFTPA 680

Query: 670  FANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNK 729
            FA+ GR T   RG P              +G RRSQ G R+EPRKII TV + ED+ L K
Sbjct: 681  FADFGRQTPGGRGVPL-----------LNVGSRRSQPGQRREPRKII-TVSVKEDVHLKK 728

Query: 730  AEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAID 789
            AE AWKPS KR     D   +D +  KTQ+LFR+VRSILNKLTPQMF QLMKQV+ L +D
Sbjct: 729  AENAWKPSQKR-----DSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVD 783

Query: 790  TEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQK 849
            TEERLKGVIDL+FEKAI EP+FSVAYANMCRCL+ LKVP  +KP  TVNFRKLLLNRCQK
Sbjct: 784  TEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQK 843

Query: 850  EFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLK 909
            EFEKDK DD+VFEKKQKE++ A+  EER RL +ELEEA+D ARRRS+GNIKFIGELFKLK
Sbjct: 844  EFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLK 903

Query: 910  MLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEK 969
            MLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKI+KE+
Sbjct: 904  MLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKER 963

Query: 970  KTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSD 1029
            KTSSRIRFMLQDV+DLR  NWV RR DQGPKTI+QIHKEA++EE  E  KVQQLM K  +
Sbjct: 964  KTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTK--E 1021

Query: 1030 KRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGG 1089
            KRR          G+  VD+GGWNTV  +K SR +D S+  KITKP +ID   QL     
Sbjct: 1022 KRR---------PGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKP-TIDEKIQLVPKAQ 1071

Query: 1090 RLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTEST-------DNRR-VV 1141
              SWGKGSSGG+ A  +D    A R + S+LNRFSALQ   P+ ST       D+RR + 
Sbjct: 1072 LGSWGKGSSGGAKASETD----ALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLT 1127

Query: 1142 QRSSLSRERGEK-AGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ 1200
             R S+ RE+ +K       R     RGG   D LD           ++  EE+ RE    
Sbjct: 1128 SRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLD-----------NQSQEEQRREMLET 1176

Query: 1201 PEGLRKAASLTEDRDRGRDAVKREAALPPVSPL----KAALSEEELEKKSKAIIEEYLHL 1256
             + L     +  +         RE+A P +S +    KAALSEEELE+KSK+II+E+LH+
Sbjct: 1177 VKQLTGGVDVERNSTEAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHI 1236

Query: 1257 NDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYY 1316
            ND KEA+QCV+EL +  LL +FVR GVESTLERS I R+HMGQLL+QL+ +  LS   ++
Sbjct: 1237 NDFKEAMQCVEELNAQGLLHVFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFF 1296

Query: 1317 QGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLL 1376
            +G  E LELA+DM IDIPH+WLYLAELVTP+L+EGG+ M EL  E +KPL P+G+A  LL
Sbjct: 1297 KGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLL 1356

Query: 1377 LEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGE---ESEAP 1433
             EIL LLCK M  KKVG LWREA LSWK+FLPEG+D+  F+ EQK+++   +    SEA 
Sbjct: 1357 SEILHLLCKQMSHKKVGALWREADLSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEAL 1416

Query: 1434 GQRALPSEELNRQLEKLLKEGSSN-QRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAII 1492
             ++ L +EEL ++LEKL+ E  +N +++FDW+EANL E Q+ S T +RALMTAVC +AII
Sbjct: 1417 SKKELSAEELYKRLEKLIIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAII 1476

Query: 1493 FE-TPLRVDVAVLKARAKLLQKYL-CDEQKELQALYALQALVVTLEQPPNLLRMFFDALY 1550
             + +  RVD AV+K R  +L KYL  D +KELQALYALQA +V L+QP NLLRMFFD LY
Sbjct: 1477 ADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLY 1536

Query: 1551 DEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN 1599
            DE+V+ EDAFY WESSKDPAEQ GKGVALKSVTAFF WLREAEEES+ N
Sbjct: 1537 DEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEESEDN 1585


>gi|110630018 eukaryotic translation initiation factor 4 gamma, 2
            isoform 2 [Homo sapiens]
          Length = 869

 Score =  196 bits (498), Expect = 2e-49
 Identities = 128/353 (36%), Positives = 192/353 (54%), Gaps = 34/353 (9%)

Query: 707  GPRKEPRKIIATVLMTEDIKLNKAEKA--WKPSSKRTAADKDRGEEDADGSKTQD-LFRR 763
            G R  P+    T   +E +     + A  W P+      D       A+  +  D +FR+
Sbjct: 21   GSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRK 80

Query: 764  VRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLM 823
            VR ILNKLTP+ F +L  ++  + ++++  LKGVI LI +KA+ EP +S  YA +C  L 
Sbjct: 81   VRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRL- 139

Query: 824  ALKVPTTEKPTV--------TVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAE 875
            A   P  + P          +  FR+LL+++ Q EFE    + +V++K++  +       
Sbjct: 140  AEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPL------- 192

Query: 876  ERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDE------ 929
                L EE EE R IA+ + LGNIKFIGEL KL ++ E+I+H C+  LL+          
Sbjct: 193  ----LPEE-EEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDM 247

Query: 930  -ESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGS 988
             E LECLC+++ T+G  LD E+AK  MDQYF +M  ++  K+  +RIRF+LQD ++LR  
Sbjct: 248  GEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREH 307

Query: 989  NWVPRRG--DQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPP 1039
            +WVPR+   D GPKTI+QI ++A +++    I         SD    GP  PP
Sbjct: 308  HWVPRKAFLDNGPKTINQIRQDA-VKDLGVFIPAPMAQGMRSDFFLEGPFMPP 359



 Score =  113 bits (282), Expect = 2e-24
 Identities = 107/386 (27%), Positives = 176/386 (45%), Gaps = 33/386 (8%)

Query: 1228 PPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPS-LLFIFVRHGVEST 1286
            P  +  K   S+EEL K ++ ++ EYL+  +  EAV  V+E+ +P   L   +   +  +
Sbjct: 492  PAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILS 551

Query: 1287 LERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTP 1346
            L+RS   +E    L+  L   G  ++  + Q    +L+    +E+DIP V  YLA+    
Sbjct: 552  LDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAAR 611

Query: 1347 ILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEF 1406
             +    V + EL     +PL   G    L L  L  L K    + +  L++++ ++ ++ 
Sbjct: 612  AIISELVSISEL----AQPLES-GTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKM 666

Query: 1407 LPEGQDIGAFVAEQKVEYTLGEESEAPGQRAL-PSEELNRQLEKLLKEGSSNQRVFDWIE 1465
            LPE         +Q  +  L E  E  G   L P  +L ++L K +K   S Q ++ WI+
Sbjct: 667  LPE--------IDQNKDRML-EILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIK 717

Query: 1466 ANLSEQQIVSNTLVRALMTAVCY---------------SAIIFETPLRVDVAVLKARAKL 1510
             N+S +  V    V  LMT+                  S+   +  L  +  +L +   +
Sbjct: 718  DNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPV 777

Query: 1511 LQKYLCDE-QKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDP 1569
            +QK+L D    ++ ALYALQ        P  +L  FF   YD ++++E+AF +W+     
Sbjct: 778  MQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKED-IT 836

Query: 1570 AEQQGKGVALKSVTAFFKWLREAEEE 1595
             E  GKG AL  V  +  WL  AEEE
Sbjct: 837  QEFPGKGKALFQVNQWLTWLETAEEE 862


>gi|4503539 eukaryotic translation initiation factor 4 gamma, 2
            isoform 1 [Homo sapiens]
          Length = 907

 Score =  196 bits (498), Expect = 2e-49
 Identities = 128/353 (36%), Positives = 192/353 (54%), Gaps = 34/353 (9%)

Query: 707  GPRKEPRKIIATVLMTEDIKLNKAEKA--WKPSSKRTAADKDRGEEDADGSKTQD-LFRR 763
            G R  P+    T   +E +     + A  W P+      D       A+  +  D +FR+
Sbjct: 21   GSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRK 80

Query: 764  VRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLM 823
            VR ILNKLTP+ F +L  ++  + ++++  LKGVI LI +KA+ EP +S  YA +C  L 
Sbjct: 81   VRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRL- 139

Query: 824  ALKVPTTEKPTV--------TVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAE 875
            A   P  + P          +  FR+LL+++ Q EFE    + +V++K++  +       
Sbjct: 140  AEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPL------- 192

Query: 876  ERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDE------ 929
                L EE EE R IA+ + LGNIKFIGEL KL ++ E+I+H C+  LL+          
Sbjct: 193  ----LPEE-EEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDM 247

Query: 930  -ESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGS 988
             E LECLC+++ T+G  LD E+AK  MDQYF +M  ++  K+  +RIRF+LQD ++LR  
Sbjct: 248  GEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREH 307

Query: 989  NWVPRRG--DQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPP 1039
            +WVPR+   D GPKTI+QI ++A +++    I         SD    GP  PP
Sbjct: 308  HWVPRKAFLDNGPKTINQIRQDA-VKDLGVFIPAPMAQGMRSDFFLEGPFMPP 359



 Score =  113 bits (282), Expect = 2e-24
 Identities = 107/386 (27%), Positives = 176/386 (45%), Gaps = 33/386 (8%)

Query: 1228 PPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPS-LLFIFVRHGVEST 1286
            P  +  K   S+EEL K ++ ++ EYL+  +  EAV  V+E+ +P   L   +   +  +
Sbjct: 530  PAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILS 589

Query: 1287 LERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTP 1346
            L+RS   +E    L+  L   G  ++  + Q    +L+    +E+DIP V  YLA+    
Sbjct: 590  LDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAAR 649

Query: 1347 ILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEF 1406
             +    V + EL     +PL   G    L L  L  L K    + +  L++++ ++ ++ 
Sbjct: 650  AIISELVSISEL----AQPLES-GTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKM 704

Query: 1407 LPEGQDIGAFVAEQKVEYTLGEESEAPGQRAL-PSEELNRQLEKLLKEGSSNQRVFDWIE 1465
            LPE         +Q  +  L E  E  G   L P  +L ++L K +K   S Q ++ WI+
Sbjct: 705  LPE--------IDQNKDRML-EILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIK 755

Query: 1466 ANLSEQQIVSNTLVRALMTAVCY---------------SAIIFETPLRVDVAVLKARAKL 1510
             N+S +  V    V  LMT+                  S+   +  L  +  +L +   +
Sbjct: 756  DNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPV 815

Query: 1511 LQKYLCDE-QKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDP 1569
            +QK+L D    ++ ALYALQ        P  +L  FF   YD ++++E+AF +W+     
Sbjct: 816  MQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKED-IT 874

Query: 1570 AEQQGKGVALKSVTAFFKWLREAEEE 1595
             E  GKG AL  V  +  WL  AEEE
Sbjct: 875  QEFPGKGKALFQVNQWLTWLETAEEE 900


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  100 bits (249), Expect = 1e-20
 Identities = 113/461 (24%), Positives = 169/461 (36%), Gaps = 58/461 (12%)

Query: 11  PPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAA 70
           PP+P    P P  PP  +AP    T  +     PSQ      PS   PP  A   +Q+  
Sbjct: 332 PPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAP----PSMTTPPMQAPPSLQTIP 387

Query: 71  PAR-------PGPAAHVYPAGSQVMMIPSQISYPASQGAYYI----PGQGRSTYVVPTQQ 119
           P +       P   A   P     +   + +  P  Q  +      P Q +++   P++ 
Sbjct: 388 PIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRP 447

Query: 120 YPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKT 179
               P +P       P +      A  P Q      T ++PA   ++ P  I P +   +
Sbjct: 448 ASTPPDSP-------PLQAPLSLPASPPLQ------TSLSPAVSPLSSPLTIHPLQALSS 494

Query: 180 IRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGA 239
           +    P      ++  IM    T S+  PP            +TP  ++   P +     
Sbjct: 495 LASHSPQA---PLSSLIMPPLETQSSLAPPSL----------QTPPASLTTPPLENLPSL 541

Query: 240 IIADRPGLPGPEHSPSESQPSSPSPTP---SPSPVLEPGSEPNLAVLSIPGDTMTTIQMS 296
                     P  +P    P  P+P P    PSP+  P  E   ++ + P      +   
Sbjct: 542 APPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALA-- 599

Query: 297 VEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV 356
              S P+      P      P P A P L +    + P P +    SPL  P+P A + +
Sbjct: 600 ---SPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656

Query: 357 EIH---EPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAV 413
            +H    P    PS  ++     SP  A PP  PS +P   AP +     L   PSPPA 
Sbjct: 657 AVHLLQAPFSPPPSPPVQAPF--SPP-ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 713

Query: 414 D-LSPVSEPEEQAKEVTAS--MAPPTIPSATPATAPSATSP 451
             +SP + P  QA    A+  +  P  P A+P  +PSAT P
Sbjct: 714 PPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 117/490 (23%), Positives = 172/490 (35%), Gaps = 71/490 (14%)

Query: 12  PAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAP 71
           P+   GL +PA     ++    S+P  +  +    PR   +PS+ +P    A R     P
Sbjct: 228 PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 287

Query: 72  ARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYP 131
            R   A  + P  S  +  PS    P+   A  +P    +   +P       P +P   P
Sbjct: 288 PRKDAAPALGPLSSSPLATPS----PSGTKARPVPPPDNAATPLPA----TLPPSP---P 336

Query: 132 GASPTEFGTYAGAYYPAQGVQQFPTGVAP--APVLMNQPPQIAPKRERKTIRIRDPNQGG 189
            A+P      + +  P+      P    P  AP  M  PP  AP     +++   P Q  
Sbjct: 337 LATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPP----SLQTIPPIQVP 392

Query: 190 KDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVA-----VIVRPDDRSQGAIIADR 244
             +T   +        P  P     L+   +  +P +      + + P           R
Sbjct: 393 HSLTSPSLQA------PPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSR 446

Query: 245 PGLPGPEHSPSE---SQPSSPSPTPSPSPVLEPGSEP----NLAVLSIPGDTMTTIQMSV 297
           P    P+  P +   S P+SP    S SP + P S P     L  LS          +S 
Sbjct: 447 PASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSS 506

Query: 298 EESTPISRETG-EPYRLSPEPTPLAEPILEVEVTL--------SKPVPESEFSSSPLQAP 348
               P+  ++   P  L   P  L  P LE   +L        S P+      + P  AP
Sbjct: 507 LIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAP 566

Query: 349 TPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPA----CPSESPVPIAPTAQPEEL- 403
            PL +    +  P    PS    P  ++ P LA PP      P  SP+   P   P  L 
Sbjct: 567 CPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLA 626

Query: 404 ---LNGAPSPPAVD-LSPVSEPEEQAKE------------------VTASMAPPTIPSAT 441
              L   PSPPA   LSP++ P  QA                    V A  +PP  P  +
Sbjct: 627 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 686

Query: 442 PATAPSATSP 451
           P+  P + +P
Sbjct: 687 PSATPPSQAP 696



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 130/539 (24%), Positives = 174/539 (32%), Gaps = 62/539 (11%)

Query: 4    APQSTGPPPA-----PSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQP 58
            AP S   PPA     P   LP  A PP QTA    +TP    + TP  P     P   Q 
Sbjct: 519  APPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPH---LETPPCPA----PCPLQA 571

Query: 59   PSSAASRVQSAAP---ARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVV 115
            P S  +      P   A P P A    A   +  +PS    P S  A   P       + 
Sbjct: 572  PPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSP---PLSPLATPPPQAPPXLALP 628

Query: 116  PTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKR 175
            P Q  P  P +P   P A+P+     A A +    + Q P    P+P +  Q P   P  
Sbjct: 629  PLQAPPSPPASPPLSPLATPSPQAPNALAVH----LLQAPFSPPPSPPV--QAPFSPPAS 682

Query: 176  ERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVR---- 231
               +     P+Q    +    +      S P  P       P      P  A  ++    
Sbjct: 683  PPVSPSATPPSQAPPSLAAPPLQVP--PSPPASPPMSPSATPPPQAPPPLAAPPLQVPPS 740

Query: 232  -PDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTM 290
             P            P +P    +P    P SP  +   SP+ +P  +   A+ + P   +
Sbjct: 741  PPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQAL 800

Query: 291  TTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAP-- 348
             +   S     P S     P      P P A P+L   +     VP S  +S  LQAP  
Sbjct: 801  PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL---QVPPSPPASPTLQAPRR 857

Query: 349  TPLASHTVEIHEPN---GMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLN 405
             P       +  P     + P     P    S  L+ P      S    + T+ PEE L 
Sbjct: 858  PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS----SATSTPEE-LR 912

Query: 406  GAPSPP--AVDLSPVSEPEEQAKEVTASMAPPTIPSA------TPATAPSATSPAQEEEM 457
            G  S P      SP  + E  A    A    P  P A       P   P AT P   + +
Sbjct: 913  GYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGL 972

Query: 458  EEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRR 516
                E E  E+        + G          P P        A A    +   PK+ R
Sbjct: 973  CTIYETEGPESATPAPGALDPG----------PSPGTSGGKAAAGAGAGASSRSPKQAR 1021



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 110/476 (23%), Positives = 171/476 (35%), Gaps = 45/476 (9%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQM--------NTPSQPRQHFYPS 54
           KA  +   P A +PGL  P  PPG   P    TP A ++          P   R      
Sbjct: 9   KAGAAARTPAARAPGLLTPR-PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG 67

Query: 55  RAQPPSSA-ASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGR-ST 112
              P S+  A   +SA  +   PA+    +G      P++ + P   G    PG+   +T
Sbjct: 68  ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSP---GPVSSPGRASGTT 124

Query: 113 YVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQP---- 168
              P  Q  ++  A         TE    +     A+     PT   P+P +  +     
Sbjct: 125 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184

Query: 169 PQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTP---PQTGGGLEPQANGETPQ 225
            ++   R   + R R P +G +         + T  +P     P  GGGL+  A+     
Sbjct: 185 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 244

Query: 226 VAVIVRPDDRS----QGAIIAD-RPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNL 280
            A  +    RS    +G   A   P  P P+   +   P    P    +P L P S   L
Sbjct: 245 SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL 304

Query: 281 AVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEF 340
           A  S  G     +      +TP+      P  L P P PLA P+      L+ P P +  
Sbjct: 305 ATPSPSGTKARPVPPPDNAATPL------PATLPPSP-PLATPL-----PLAPPSPSAPP 352

Query: 341 SSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES----PVPIAP 396
           S   L  P+P A+   +   P+   P     P +++ P +  P +  S S    P P+A 
Sbjct: 353 SLQTL--PSPPATPPSQA-PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLAL 409

Query: 397 TAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
           ++       G+P+  A        P +    +T+   P + P  +P      + PA
Sbjct: 410 SSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPA 465



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 76/347 (21%), Positives = 116/347 (33%), Gaps = 53/347 (15%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
           +AP S    P  SP     A PP Q  P + + P     + P+ P     PS   PP + 
Sbjct: 674 QAPFSPPASPPVSPS----ATPPSQAPPSLAAPPLQVPPSPPASPPMS--PSATPPPQAP 727

Query: 63  ASRVQSAAPARPGPAAH--VYPAGSQVMMIPSQISYPASQGAYYIPGQ-GRSTYVVPTQQ 119
                      P P A   + P+ +    +P  ++ P  Q     P     S    P  Q
Sbjct: 728 PPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQ 787

Query: 120 YP---------VQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAP--APVLMNQP 168
            P           P  P  +PG +P         + P+  +   P    P  AP ++  P
Sbjct: 788 APPALATPPLQALPSPPASFPGQAP---------FSPSASLPMSPLATPPPQAPPVLAAP 838

Query: 169 PQIAPKRERKTIRIRDPNQGGKDITEEIMSGAR--TASTPTPPQ----------TGGGLE 216
               P     +  ++ P +      +  +SG R   A  P PP           +G  L 
Sbjct: 839 LLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA 898

Query: 217 PQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLE--P 274
             ++  T     +   D   +G   A     P P+   +   P++ S  P+P       P
Sbjct: 899 GHSSSATSTPEELRGYDSGPEGGAAAS----PPPDAELAACHPAAWSRGPAPPLAFRGAP 954

Query: 275 GSEPNLAVLSIPG--DTMTTIQMSVEESTPISRETGEPYRLSPEPTP 319
           G+       + PG  D + TI     E+      T  P  L P P+P
Sbjct: 955 GAPLPWPPATGPGSADGLCTIY----ETEGPESATPAPGALDPGPSP 997


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 142/585 (24%), Positives = 196/585 (33%), Gaps = 111/585 (18%)

Query: 5    PQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAAS 64
            P +  P  AP P    P  P G  A         T   TP  P+       A PP   A 
Sbjct: 1094 PATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGL----ATPPPKGAP 1149

Query: 65   RVQSAAPARP-GPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQ 123
               +A P  P G  A   P G+      +    P+ +G    P    S    PT      
Sbjct: 1150 TTPAATPPSPKGGLATPPPKGAPTTPAATP---PSPKGGLATP----SPKGAPTTPAATP 1202

Query: 124  PGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIR 183
            P   G     SP             +G    P    P+P      P  +PK    T    
Sbjct: 1203 PSPKGGLATPSP-------------KGAPTTPAATPPSPKGGLATP--SPKGAPTTPAAT 1247

Query: 184  DPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIAD 243
             P+  G   T     GA T    TPP   GGL    +   P  AV+  P  +        
Sbjct: 1248 PPSPKGGPATPP-PKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKG------- 1299

Query: 244  RPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPI 303
                 GP  SP +  P+ P+ TP PSP   PG+ P     + P  T              
Sbjct: 1300 -----GPATSPPKGAPTPPAATP-PSPKGSPGTPPPKGAPTPPAVT-------------- 1339

Query: 304  SRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNG 363
                         P+P   P L      SK  P +  S    + PTP A+       P  
Sbjct: 1340 ------------PPSPKGTPTLPATTPSSKGGPTTPSSK---EGPTPPAATPSHKGGP-A 1383

Query: 364  MVPSEDLEPEVESSPELAPPPACP-SESPVPIAPTAQPEELL--NGAPSPPAVDLSPVSE 420
            M P     P  +  P +  P   P S + +P++P   P   +   GA +P   DL+P + 
Sbjct: 1384 MTP-----PSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAV 1438

Query: 421  PEEQAKEVTASMAP---PTIPSAT-PATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAES 476
                 K+  A+ AP   P  PS+    T P+ T P+ +E    ++        +A    +
Sbjct: 1439 TPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPA 1498

Query: 477  EKGGEEL---LPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDA 533
              G   L   +P     +PA  S   +  A T   +S    ++    L  KEA+      
Sbjct: 1499 PMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLS----KKTPATLAPKEAL------ 1548

Query: 534  FKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKE 578
                          PPA + P P+   +   P P+EA  T  SKE
Sbjct: 1549 -------------IPPAMTVPSPKK--TPAIPTPKEAPATPSSKE 1578



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 140/586 (23%), Positives = 200/586 (34%), Gaps = 61/586 (10%)

Query: 4    APQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAA 63
            +P   G P  P+   P P   P   +P    TP A    +P        P  A  P +A 
Sbjct: 933  SPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAAT 992

Query: 64   SRVQSAAPARPGP-AAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPV 122
                   PA P P  A   PA +      S  + P  +GA   P     +        P+
Sbjct: 993  PPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPL 1052

Query: 123  QPGAPGFYPGASPTEFG-----TYAGAYYPAQGVQQFPTG--VAPAPVLMNQPPQIAPKR 175
              GAP       P+  G     +  GA  P       P G    P+P     PP   P  
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS 1112

Query: 176  ERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 235
             +    +  P   G   T      +      TPP  G    P A   +P+  +   P   
Sbjct: 1113 PKG--GLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKG 1170

Query: 236  SQGAIIADRPGLPGPEHSPS-ESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQ 294
            +     A  P   G   +PS +  P++P+ TP PSP      +  LA  S  G   T   
Sbjct: 1171 APTTPAATPPSPKGGLATPSPKGAPTTPAATP-PSP------KGGLATPSPKGAPTT--- 1220

Query: 295  MSVEESTPISRETG--EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQ-APTPL 351
                 +TP S + G   P       TP A P          P P+   ++ P + APTP 
Sbjct: 1221 ---PAATPPSPKGGLATPSPKGAPTTPAATP----------PSPKGGPATPPPKGAPTPP 1267

Query: 352  ASHTVEIHEPNGMVPSEDL-EPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSP 410
            A+    +       P +    P V + P     PA       P  P A P        +P
Sbjct: 1268 AATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTP 1327

Query: 411  PAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGE 470
            P     P   P   A    +    PT+P+ TP++    T+P+ +E           + G 
Sbjct: 1328 P-----PKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382

Query: 471  AGEAESEKGGEELLPPESTPI-PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGD 529
            A    S K G  +  P+  P  PA +  + + A AT V           +E     + GD
Sbjct: 1383 AMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVT----------REGAATPSKGD 1432

Query: 530  LLD------AFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEE 569
            L        + K+A PA    +  P   S+ G  +  +  PP P+E
Sbjct: 1433 LTPPAVTPVSLKKA-PATSAPKGGPATPSSKGDPTLPAVTPPSPKE 1477



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 153/651 (23%), Positives = 222/651 (34%), Gaps = 109/651 (16%)

Query: 11   PPAPSPGLPQPAFPPGQTAPVVFSTPQATQ------MNTPSQPRQHFYPSRAQPPSSAAS 64
            PP+P  GL   A PP + AP   +TP AT       + TPS       P+ A PPS    
Sbjct: 1156 PPSPKGGL---ATPPPKGAP---TTPAATPPSPKGGLATPSPKGAPTTPA-ATPPSPKGG 1208

Query: 65   RVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQP 124
                +    P   A   P+    +  PS    P +  A   P         P +  P  P
Sbjct: 1209 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP-PSPKGGPATPPPKGAPTPP 1267

Query: 125  GA--PGFYPG-ASPTEFGTYAGAYY----PAQGVQQFPTGVAPAPVLMNQPPQIAPKRER 177
             A  P    G A+P   G    A      P  G    P   AP P     P   +PK   
Sbjct: 1268 AATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPP---SPKGSP 1324

Query: 178  KTIRIRDPNQGGKD---ITEEIMSGARTASTPTPPQTGGGLEPQAN-GETPQVAVIVRPD 233
             T     P +G      +T     G  T    TP   GG   P +  G TP  A    P 
Sbjct: 1325 GT----PPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAAT---PS 1377

Query: 234  DRSQGAIIADRP----GLPGPEHSPSESQ--PSSPSPTPSPSPVLEPGSEPNLAVLSIPG 287
             +   A+    P     +P P+  P+     P SP   P+     E  + P+   L+ P 
Sbjct: 1378 HKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPA 1437

Query: 288  DTMTTIQMSVEESTP-----ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSS 342
             T  +++ +   S P          G+P   +  P    EP    +V  S    ++  + 
Sbjct: 1438 VTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATP 1497

Query: 343  SPLQAPT---------------------PLASHTVEIHE--PNGMVPSEDLEPEVESSPE 379
            +P+ APT                     P+A     + +  P  + P E L P   + P 
Sbjct: 1498 APMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPS 1557

Query: 380  LAPPPACPSESPVPIAPTAQPEE--------LLNGAPSPPAVDLSP-VSEPEEQAKEVTA 430
                PA P+    P  P+++              GAPSP  + + P V+ P  +      
Sbjct: 1558 PKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPP 1617

Query: 431  SMAPPTIPS--ATPATAPSATSPAQEEEMEEEEEEEEGE--------AGEAGEAESEKGG 480
            ++ PP+     ATPA   + TSP       ++                 +A +    K G
Sbjct: 1618 AVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKG 1677

Query: 481  EELL-------PPESTPI---PANLSQNLEAAAATQVAVSV-PKRRRKIKELNKKEAVGD 529
               L        PESTPI   P       + ++AT   +   P  +   K      A   
Sbjct: 1678 PTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAP 1737

Query: 530  LLDAFKEAN-PAVPEVENQPPAGSNPGPESEGS---------GVPPRPEEA 570
            LL   K+++  A  +  +  P G    PES+ S          V P+PE A
Sbjct: 1738 LLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESA 1788



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 140/588 (23%), Positives = 196/588 (33%), Gaps = 83/588 (14%)

Query: 10   PPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSA 69
            P   PSP LP    PPG T  V   +  +      S P++   P+     S+ AS   + 
Sbjct: 731  PKSVPSPSLPPAGTPPG-TKKVDGISHTSALAPVASSPKE--CPTEDSGASATASSKGTL 787

Query: 70   APARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGF 129
                  P+    P G  V + P     P  +G+      G  T  +     PV P    F
Sbjct: 788  TYLADSPS----PLG--VSVSPQTKRPPTKKGS-----AGPDT-PIGNLSSPVSPVEASF 835

Query: 130  YP-------GASPTEFGTYAGAYYPAQGVQQFPTGVAP-APVLMNQPPQIAPKRERKTIR 181
             P       G+  +   T++      +G    P+ V P +P  +  PP+  P      + 
Sbjct: 836  LPENSLSFQGSKDSPATTHSPTPPSPKGAPT-PSAVTPLSPKGVTLPPKETP--TPSVVN 892

Query: 182  IRDPNQG-GKDITEEIMSGARTASTP-----TPPQTGGGLEPQANG-ETPQVAVIVRPDD 234
            +  P +G      ++  + + T+S+P     TP   G    P   G  TP  A    P  
Sbjct: 893  LPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSP-- 950

Query: 235  RSQGAIIADRPGLPGPEHSPSESQPSSPSP-----TPSPSPVLEPGSEPNLAVLSIPGDT 289
                      P  P P+ +P+    + PSP     TPSP     P   P     S  G  
Sbjct: 951  -------KGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPPSPKGGP 1000

Query: 290  MTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPT 349
             T       +  P       P   SP+ +P A P  +   T     P S    SP   P 
Sbjct: 1001 AT----PSPKGAPTPPAVTPP---SPKGSPAATPFPKGASTPPAATPPSP-KGSPAATPL 1052

Query: 350  PLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPS 409
            P  + T     P   +PS    P   S      PPA    SP     T  P+    GAP 
Sbjct: 1053 PKGAPTT----PAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK----GAPM 1104

Query: 410  PP-AVDLSP---VSEPEEQAKEVTASMAPP-------TIPSATPATAPSATSPAQEEEME 458
            PP A   SP   ++ P  +    T +  PP       T P     T P+AT P+ +  + 
Sbjct: 1105 PPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL- 1163

Query: 459  EEEEEEEGEAGEAGEAESEKGGEELLPPESTP-IPANLSQNLEAAAATQVAVSVPKRRRK 517
                 +      A    S KGG     P+  P  PA    + +   AT      PK    
Sbjct: 1164 ATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLAT----PSPKGAPT 1219

Query: 518  IKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPP 565
                      G L     +  P  P      P G    P  +G+  PP
Sbjct: 1220 TPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPP 1267



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 136/642 (21%), Positives = 216/642 (33%), Gaps = 123/642 (19%)

Query: 21   PAFPPGQTAPVVFSTPQAT-QMNTPSQPRQHFYPSRAQPP----SSAASRVQSAAPARPG 75
            P+F    ++P +  +P+AT    +  +P     P+ +       +S+AS +++ + A P 
Sbjct: 571  PSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPD 630

Query: 76   PAAHVYPAGSQVMMIPSQISYP--ASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGA 133
             A    P     ++ P+  ++P  ++  A   P   + T    T   P   G     P  
Sbjct: 631  SAG---PLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKN 687

Query: 134  SPTEFGTYAGAYYPAQGVQQFPTGVAP------------APVLMNQ------PPQIAPKR 175
             P + GT           +  P   +P            AP +         PP   P  
Sbjct: 688  HPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPG 747

Query: 176  ERK------TIRIRDPNQGGKDITEEIMSGARTASTP--------TPPQTGGGLEPQ--- 218
             +K      T  +       K+   E    + TAS+         +P   G  + PQ   
Sbjct: 748  TKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKR 807

Query: 219  -------ANGETPQVAVIVRPDDRSQGAIIADRP-GLPGPEHSPSESQ-PSSPSPTPSPS 269
                   A  +TP +  +  P    + + + +      G + SP+ +  P+ PSP  +P+
Sbjct: 808  PPTKKGSAGPDTP-IGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866

Query: 270  P-----------VLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPT 318
            P            L P   P  +V+++P         + +++  +S  +  P +    P 
Sbjct: 867  PSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPA 926

Query: 319  PLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSP 378
            P   P                 S SP  APTP A+ T    +     PS    P   + P
Sbjct: 927  PKGIPA----------------SPSPKGAPTPPAA-TPPSPKGGPATPSPKWAP---TPP 966

Query: 379  ELAPP-----PACPSESPVPIAPTAQPEE--------LLNGAPSPPAVDL-----SPVSE 420
               PP     PA PS    P  P A P             GAP+PPAV       SP + 
Sbjct: 967  AATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAAT 1026

Query: 421  PEEQAKEVTASMAPPT---IPSATP-----ATAPSATSPAQEEEMEEEEEEEEGEAGEAG 472
            P  +      +  PP+    P+ATP      T P+AT P+ +         +      A 
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG-PATPSLKGAPTPPAA 1085

Query: 473  EAESEKGGEELLPPESTPI-PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLL 531
               S KGG     P+  P+ PA    + +   AT      P          K    G L 
Sbjct: 1086 TPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPK----GGLA 1141

Query: 532  DAFKEANPAVPEVENQPPAGSNPGPESEG-----SGVPPRPE 568
                +  P  P      P G    P  +G     +  PP P+
Sbjct: 1142 TPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1183



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 110/501 (21%), Positives = 161/501 (32%), Gaps = 98/501 (19%)

Query: 5    PQSTGPPPAPSPGLPQPA---FPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSS 61
            P +T P P  SPG P P     PP  T P    TP      TPS       PS  + P+ 
Sbjct: 1313 PAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTP-TLPATTPSSKGGPTTPSSKEGPTP 1371

Query: 62   AASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVP-TQQY 120
             A     A P+  G  A   P+  +   IPS    P S     IP   +     P T++ 
Sbjct: 1372 PA-----ATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAV--IPLSPKKAPATPVTREG 1424

Query: 121  PVQPGAPGFYPGA--------SPTEFGTYAGAYYPA-QGVQQFPTGVAPAPVLMNQPPQI 171
               P      P A        +P       G   P+ +G    P    P+P     P Q+
Sbjct: 1425 AATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQV 1484

Query: 172  APKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVR 231
            A     K         G   +   I S  +     TP      + P A   + +    + 
Sbjct: 1485 ATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPA-TPSSRRDPIAPTATLLSKKTPATLA 1543

Query: 232  PDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMT 291
            P +    A+I     +P P+ +P+   P     TPS      P +         P     
Sbjct: 1544 PKE----ALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKEL 1599

Query: 292  TIQMSVEES-----------TPISRETGEPYRLSPEPTPLAEPILE-------------- 326
             I  +V              TP S E G P   +P+ TP + P+                
Sbjct: 1600 LIPPAVTSPSPKEAPTPPAVTPPSPEKG-PATPAPKGTPTSPPVTPSSLKDSPTSPASVT 1658

Query: 327  ----------------------VEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGM 364
                                  ++  L  P PE   S+  + APT     T         
Sbjct: 1659 CKMGATVPQASKGLPAKKGPTALKEVLVAPAPE---STPIITAPTRKGPQT--------- 1706

Query: 365  VPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQ 424
                  +    +SP + P P+  + S  P++ T  P  LL     P   D S  ++ ++ 
Sbjct: 1707 ------KKSSATSPPICPDPSAKNGSKGPLS-TVAPAPLL-----PVQKDSSKTAKGKDA 1754

Query: 425  AKEVTASMAPPTIPSATPATA 445
            +      +APP   ++TP TA
Sbjct: 1755 SHSPKGPLAPPESKASTPLTA 1775



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 109/467 (23%), Positives = 167/467 (35%), Gaps = 82/467 (17%)

Query: 5    PQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAAS 64
            P S   P AP+  L      P   AP     P A  M  PS  +    P+  + P++ +S
Sbjct: 1520 PSSRRDPIAPTATLLSKK-TPATLAPKEALIPPA--MTVPSPKKTPAIPTPKEAPATPSS 1576

Query: 65   RVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPG-------QGRSTYV--- 114
            +  S+ PA   P+ +      + ++IP  ++ P+ + A   P        +G +T     
Sbjct: 1577 KEASSPPAVT-PSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKG 1635

Query: 115  VPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQG----VQQFPTG-----VAPAPV-- 163
             PT   PV P +    P  SP       GA  P        ++ PT      VAPAP   
Sbjct: 1636 TPTSP-PVTPSSLKDSP-TSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPEST 1693

Query: 164  -LMNQPPQIAPKRERKTIR----IRDPN--QGGKDITEEIMSGARTASTPTPPQTGGGLE 216
             ++  P +  P+ ++ +        DP+   G K     +             +T  G +
Sbjct: 1694 PIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKD 1753

Query: 217  PQANGETPQVAVIVRPDDRSQGAIIAD--RPGLPGPEH-------SPSESQPSSPSPTPS 267
               + + P    +  P+ ++   + A      LP PE        SP  S P +PSP P+
Sbjct: 1754 ASHSPKGP----LAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPT 1809

Query: 268  PSPVLE-PGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILE 326
              P  +   S P L VL  P   +       +E  P+         + PEP     P   
Sbjct: 1810 LPPKQQFLPSSPGL-VLESPSKPLA--PADEDELLPL---------IPPEPISGGVPFQS 1857

Query: 327  VEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPAC 386
            V V +  P       S+ +  PTP A   V  +       S+      ES PEL      
Sbjct: 1858 VLVNMPTP------KSAGIPVPTPSAKQPVTKNNKGSGTESD----SDESVPEL------ 1901

Query: 387  PSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMA 433
              E       T Q  +L   A     +D  PVS+ ++   E  A  A
Sbjct: 1902 --EEQDSTQATTQQAQLAAAA----EIDEEPVSKAKQSRSEKKARKA 1942



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 110/520 (21%), Positives = 180/520 (34%), Gaps = 103/520 (19%)

Query: 6   QSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASR 65
           ++T   PA    LPQP     +TA +    P ++ ++  +   Q   P    PP  + + 
Sbjct: 4   EATETVPATEQELPQPQ---AETAVL----PMSSALSVTAALGQ---PGPTLPPPCSPAP 53

Query: 66  VQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIP---GQGRSTYVVPTQQYPV 122
            Q   P      A  +P+ S +   P ++ +P S     +P        T++      P+
Sbjct: 54  QQ--CPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPI 111

Query: 123 QPGAPGFY-PGASPTEFGTYAGAYYPAQGVQQFPTGVAPA----PVLMNQPPQIAPKRER 177
            P A     P  +PT  GT + +  P   V   P  V  +    P L+  PP +A     
Sbjct: 112 SPAALALASPMIAPTLKGTPSSSA-PLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESG 170

Query: 178 KTIRIR------DPNQGGKDITEEIMSGARTASTPTPP-----------------QTGGG 214
             I +       +P      +  E++   +   TP+PP                 Q+G  
Sbjct: 171 SVITLSAPIAPSEPKTNLNKVPSEVVPNPK--GTPSPPCIVSTVPYHCVTPMASIQSGVA 228

Query: 215 LEPQANGETPQVAVIVRPDDRSQGAIIAD--RPG---LPGPEHSPS-------------E 256
             PQ    T       +  D +  +++     PG   L GP   P+              
Sbjct: 229 SLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTS 288

Query: 257 SQPSSPSPTPSPSPV-----LEPGSEPNLAVLSIPGDT-------MTTIQMSVEEST--- 301
           SQ ++   TP   P+     L P  + +   + + G T        T   +SV+ S+   
Sbjct: 289 SQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGA 348

Query: 302 --PISRETGEPYRLSPEPTPL---AEPILEVEVTLSKPVPES-------------EFSSS 343
             P  R    P     E  P    A P++   V        S              FS S
Sbjct: 349 SYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLS 408

Query: 344 PLQAPTPLASHTVEIHEP---NGMVPSEDLEPEVESSP-ELAPPPACPSESPVPIAPTAQ 399
           P  +    +S     H P      V S    P V ++P  +A  P    E    ++P   
Sbjct: 409 PTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMS 468

Query: 400 PEELLNGAP-SPPAVDLSPVSEPEEQAKEVTASMAPPTIP 438
              + N  P SP A+ ++PV+ P+E + +V  ++  P  P
Sbjct: 469 SGPISNIEPTSPAALVMAPVA-PKEPSTQVATTLRIPVSP 507



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 79/336 (23%), Positives = 117/336 (34%), Gaps = 53/336 (15%)

Query: 250 PEHSPS-ESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISR--- 305
           P++SPS +S  SSP    SP   L   S      +  P  +MT+  + V  S  + +   
Sbjct: 567 PKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTS-PLGVNSSASVIKTDS 625

Query: 306 ----ETGEPYRLSP--EPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIH 359
               ++  P   S    PT  A P+   +     P      S+    A +P    TV + 
Sbjct: 626 YAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTA-SPFLEGTVSLA 684

Query: 360 EPNGMVPSEDLE--PEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSP 417
             N  V    L   P V ++ E  P    P  +  P+A      E+    PSP    L P
Sbjct: 685 PKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSP---SLPP 741

Query: 418 VSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 477
              P    K+V          S T A AP A+SP      +E   E+ G +  A    S 
Sbjct: 742 AGTP-PGTKKVDGI-------SHTSALAPVASSP------KECPTEDSGASATA----SS 783

Query: 478 KGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRR---KIKELNKKEAVGDLLDAF 534
           KG    L    +P+  ++S               P+ +R   K         +G+L    
Sbjct: 784 KGTLTYLADSPSPLGVSVS---------------PQTKRPPTKKGSAGPDTPIGNLSSPV 828

Query: 535 KEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEA 570
                +     +    GS   P +  S  PP P+ A
Sbjct: 829 SPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGA 864


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 133/582 (22%), Positives = 202/582 (34%), Gaps = 100/582 (17%)

Query: 12  PAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAP 71
           P+   GL +PA     ++    S+P  +  +    PR   +PS+ +P    A R     P
Sbjct: 228 PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 287

Query: 72  ARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYP 131
            R   A  + P  S  +  PS  +   SQ    +P    S+ +      P+    P   P
Sbjct: 288 PRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPS--P 345

Query: 132 GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKD 191
            A P+              +Q  P+           PP   P   + T  +  P      
Sbjct: 346 SAPPS--------------LQTLPS-----------PPATPP--SQATTSLGSPT---LQ 375

Query: 192 ITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPE 251
            T   +     +   TPP       PQA    P +A+                P L  P 
Sbjct: 376 ATHSFLPSPPLSPLATPP-------PQA---PPALAL----------------PPLQAPP 409

Query: 252 HSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPY 311
            SP  S P SP  TPSP            A  S P         S   S P+S     P 
Sbjct: 410 -SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP- 467

Query: 312 RLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLE 371
             S  P  LA P L+V  +     P S  ++ P QAP PLA+  +++ +P    P     
Sbjct: 468 --SQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 525

Query: 372 PEVESSPELAPPPACPSESP------VPIAPTAQP---------EELLNGAPSPPAVDL- 415
           P +++ P  +PP + P ++P      +P++P A P           LL   PSPPA    
Sbjct: 526 PPLQALP--SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTL 583

Query: 416 -------SPVSEPEEQAKEVTASMA--PPTIPSATPATAPSATSPAQEEEMEEEEEEEEG 466
                  +P  +       +T ++A  PP  PS +P++  S    A          EE  
Sbjct: 584 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE-- 641

Query: 467 EAGEAGEAESEKGGEELLPPESTPI----PANLSQNLEAAAATQVAVSVPKRRRKIKELN 522
                G     +GG    PP    +    PA  S+      A + A   P          
Sbjct: 642 ---LRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 698

Query: 523 KKEAVGDLLDAF--KEANPAVPEVENQPPAGSNPGPESEGSG 562
             + +  + +    + A PA   ++  P  G++ G  + G+G
Sbjct: 699 SADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAG 740



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 133/519 (25%), Positives = 175/519 (33%), Gaps = 90/519 (17%)

Query: 4   APQSTGPPPA----PSPGLPQPAFPPGQTAPVVFS-TPQATQMNTPSQPRQHF-YPSRAQ 57
           AP S   PP+    PSP    PA PP Q    + S T QAT    PS P      P    
Sbjct: 341 APPSPSAPPSLQTLPSP----PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396

Query: 58  PPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPT 117
           PP+ A   +Q  AP  P  +  + P  +     P+ ++    Q  +  P         P 
Sbjct: 397 PPALALPPLQ--APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS-------PP 447

Query: 118 QQYPVQPGA-PGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRE 176
            Q P  P A P   P A+P      + A  P Q V   P    P       PPQ  P   
Sbjct: 448 VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ-VPPSPPASPPMSPSATPPPQAPPPLA 506

Query: 177 RKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRS 236
              +++  P                      PPQ    L       TP +  +  P    
Sbjct: 507 APPLQLAKP----------------------PPQAPPAL------ATPPLQALPSPP--- 535

Query: 237 QGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMS 296
                A  PG      SPS S P SP  TP P             VL+ P        + 
Sbjct: 536 -----ASFPG--QAPFSPSASLPMSPLATPPPQAP---------PVLAAP-------LLQ 572

Query: 297 VEESTPISRETGEPYRLSPEPTP---LAEPILEVEVTLSKPVPESEFSSSPLQAPTPLAS 353
           V  S P S     P R  P P P   ++ P L + +    P P S   SS L  P  LA 
Sbjct: 573 VPPSPPASPTLQAP-RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP-DLAG 630

Query: 354 HTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELL--NGAPSPP 411
           H+         +   D  P  E     +PPP     +  P A +  P   L   GAP  P
Sbjct: 631 HSSSATSTPEELRGYDSGP--EGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 688

Query: 412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEA 471
            +   P + P   A  +          SATP  AP A  P         +      AG +
Sbjct: 689 -LPWPPATGP-GSADGLCTIYETEGPESATP--APGALDPGPSPGTSGGKAAAGAGAGAS 744

Query: 472 GEA--ESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 508
             +  ++  G   L   +++ +   LS+ L  AAA   A
Sbjct: 745 SRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAA 783


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 177/796 (22%), Positives = 269/796 (33%), Gaps = 141/796 (17%)

Query: 9    GPPPAPSPG----LPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA-- 62
            G PPA  PG     P PA PP Q  P   + P A Q  T   P Q   P   +PP+    
Sbjct: 312  GKPPAQQPGHEKSQPGPAKPPAQ--PSGLTKPLAQQPGTVKPPVQP--PGTTKPPAQPLG 367

Query: 63   -----ASRVQSAAPA--RPGPAAHVYPAGSQVMMIPSQISYPASQGAYYI---------P 106
                 A +  S  P+  +PGP A   P G  V   P+Q   PA      +         P
Sbjct: 368  PAKPPAQQTGSEKPSSEQPGPKALAQPPG--VGKTPAQQPGPAKPPTQQVGTPKPLAQQP 425

Query: 107  GQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMN 166
            G           + PVQ   PG  P        T A    P +   Q P    P P    
Sbjct: 426  GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPP---- 481

Query: 167  QPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQV 226
            Q P  A    ++    + P+Q             +  ST  PPQ  G  +P     +PQ 
Sbjct: 482  QQPGPAKPPPQQPGSAKPPSQ-------------QPGSTKPPPQQPGPAKP-----SPQQ 523

Query: 227  AVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIP 286
                +P  +        +PG   P  S  +  P+ PS   S  PV + GS          
Sbjct: 524  PGSTKPPSQ--------QPGSAKP--SAQQPSPAKPSAQQSTKPVSQTGS---------- 563

Query: 287  GDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVT--LSKPVPESEFSSSP 344
                           P+   T  P    P    L + I  +  T  L   VPE    ++ 
Sbjct: 564  -------------GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTC 610

Query: 345  LQAPTPLAS--------HTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES--PVPI 394
             +  T + S        H  E+ E   +    + + +     +LAP P+ P       P+
Sbjct: 611  TECQTTVCSLCGFNPNPHLTEVKEWLCL----NCQMKRALGGDLAPVPSSPQPKLKTAPV 666

Query: 395  APTA-------QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASM--APPTIPSATPATA 445
              T+       QP++      + P  DLS   EP++    V        P+  +  P  A
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726

Query: 446  PSATSPAQEEEMEEEEEEEEGEAGEAGEAESE--KGGEELLPPESTPIPANLSQNLEAAA 503
             S + PA  +E     E+++    +    + +  K   +L+   S     ++  +   + 
Sbjct: 727  DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQ 786

Query: 504  ATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGV 563
            A +   + P +    K        G+ +  F   + A+P   +     S+PGP SE  G 
Sbjct: 787  AEE-KTTPPLKTDSAKPSQSFPPTGEKVSPFD--SKAIPRPASDSKIISHPGPSSESKG- 842

Query: 564  PPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFI 623
                         + D +   E  +  + K   K D  KP+              G Q +
Sbjct: 843  -----------QKQVDPVQKKEEPKKAQTKMSPKPDA-KPMPKGSPTPPGPRPTAG-QTV 889

Query: 624  FASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGP--DFTPSFANLGRTTLSTR 681
                Q P+         L+  + T      PT  Q    G    F  S  +     +ST 
Sbjct: 890  PTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTA 949

Query: 682  GPP----RGGPGGELPRGPAGLGPRRSQQGPR---KEPRKIIATVLMTEDIKLNKAEK-- 732
            G P    + GPG  + + PA   P  SQ  P+   + P     ++ + ++ K   AEK  
Sbjct: 950  GQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLE 1009

Query: 733  ---AWKPSSKRTAADK 745
                  P+ KRT  +K
Sbjct: 1010 PKAEQAPTVKRTETEK 1025



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 129/619 (20%), Positives = 208/619 (33%), Gaps = 109/619 (17%)

Query: 5    PQSTGP--PPAPSPGLPQP-AFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSS 61
            PQ  GP  PP   PG  +P +  PG T P     PQ      PS  +       +Q P S
Sbjct: 481  PQQPGPAKPPPQQPGSAKPPSQQPGSTKP----PPQQPGPAKPSPQQPGSTKPPSQQPGS 536

Query: 62   AASRVQSAAPARPGPAAHVYP---AGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVP-- 116
            A    Q  +PA+P       P    GS   + P  +S  A Q     P QG    + P  
Sbjct: 537  AKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQP----PSQGLPKTICPLC 592

Query: 117  ------------------TQQYPVQPGAPGFYPGASPTEFGTYA---GAYYPAQGVQQFP 155
                              T+         GF P    TE   +         A G    P
Sbjct: 593  NTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAP 652

Query: 156  TGVAPAPVLMN--------------QPPQIAPKRE----RKTIRIRDPNQGGKDITEEIM 197
               +P P L                QP Q +PK++    +   +  +P +    + +  +
Sbjct: 653  VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTL 712

Query: 198  SGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSES 257
             G+ +A    PP+    L   A  + P V     P ++ +  +  D+P  P     P+  
Sbjct: 713  HGSPSAKAKQPPE-ADSLSKPAPPKEPSV-----PSEQDKAPVADDKPKQP-KMVKPTTD 765

Query: 258  QPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEEST--PISRETGEPYRLSP 315
              SS S T  P                IP    + +Q   EE T  P+  ++ +P +  P
Sbjct: 766  LVSSSSATTKP---------------DIPS---SKVQSQAEEKTTPPLKTDSAKPSQSFP 807

Query: 316  EPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVE 375
               P  E +   +   SK +P     S  +  P P    + E      + P +  E   +
Sbjct: 808  ---PTGEKVSPFD---SKAIPRPASDSKIISHPGP----SSESKGQKQVDPVQKKEEPKK 857

Query: 376  SSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPP 435
            +  +++P    P   P+P      P        + P    SP  +P+EQ++  + ++   
Sbjct: 858  AQTKMSPK---PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP--KPQEQSRRFSLNLGSI 912

Query: 436  TIPSATPATAPSATSPAQ----EEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI 491
            T    +  T P  T   +       +  +       AG+ G       G    P +  P 
Sbjct: 913  TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG---APMKQAPA 969

Query: 492  PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAG 551
            P+    +     +T  A   P +   +K+  K  A  + L+   E  P V   E +    
Sbjct: 970  PSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPA-AEKLEPKAEQAPTVKRTETE---- 1024

Query: 552  SNPGPESEGSGVPPRPEEA 570
              P P  +   +   P++A
Sbjct: 1025 KKPPPIKDSKSLTAEPQKA 1043



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 98/404 (24%), Positives = 148/404 (36%), Gaps = 88/404 (21%)

Query: 149 QGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTP 208
           Q  Q  P G+   P L  QPP+  PK++      RDP Q  +D T + +S  +     + 
Sbjct: 197 QKEQGKPEGIIKPP-LQQQPPKPIPKQQGPG---RDPLQ--QDGTPKSISSQQPEKIKSQ 250

Query: 209 PQTGGGLEPQANGETPQVAVIVRPDDRS-------QGAIIAD---RPGLPGPEHSPSESQ 258
           P  G G   Q   +TPQ      P  R        Q  I+     +P LP P      S+
Sbjct: 251 PP-GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSP------SK 303

Query: 259 PSSPSPTPSPSPVLEPG---SEPNLA------------VLSIPGDTMTTIQ--------- 294
           P    PTP   P  +PG   S+P  A            +   PG     +Q         
Sbjct: 304 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA 363

Query: 295 MSVEESTPISRETG--EPYRLSPEPTPLAEP---------------ILEVEVTLSKPVPE 337
             +  + P +++TG  +P    P P  LA+P                   +V   KP+ +
Sbjct: 364 QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423

Query: 338 SEFSSSPLQAPTPLASHTVEIHEPN-GMVPSEDLEPEVESSPELAPPPACPSESPVPIAP 396
                SP +AP P  +    + +P  G +P++   P   S+ +  P    PS+ P P  P
Sbjct: 424 QPGLQSPAKAPGPTKT---PVQQPGPGKIPAQQAGPGKTSAQQTGPTKP-PSQLPGPAKP 479

Query: 397 ------TAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPP---TIPSATPATA-P 446
                  A+P     G+  PP+        P +Q      S   P     PS  P +A P
Sbjct: 480 PPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP 539

Query: 447 SATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTP 490
           SA  P+  +   ++  +   + G          G+ L PP  +P
Sbjct: 540 SAQQPSPAKPSAQQSTKPVSQTG---------SGKPLQPPTVSP 574



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 132/615 (21%), Positives = 206/615 (33%), Gaps = 97/615 (15%)

Query: 6    QSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASR 65
            Q TGP   PS  LP PA PP Q        PQ        QP     PS  Q P S    
Sbjct: 462  QQTGPTKPPSQ-LPGPAKPPPQQPGPAKPPPQ--------QPGSAKPPS--QQPGSTKPP 510

Query: 66   VQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPG 125
             Q   PA+P P              P     P+ Q     PG  +     P+ Q P  P 
Sbjct: 511  PQQPGPAKPSPQQ------------PGSTKPPSQQ-----PGSAK-----PSAQQP-SPA 547

Query: 126  APGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDP 185
             P       P    +  G+  P Q     P+  A  P     P  I P      + +  P
Sbjct: 548  KPSAQQSTKPV---SQTGSGKPLQPPTVSPS--AKQPPSQGLPKTICPLCNTTELLLHVP 602

Query: 186  NQGGKDITEEIMSG--ARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIAD 243
             +   +   E  +   +     P P  T          E  +   +     R+ G  +A 
Sbjct: 603  EKANFNTCTECQTTVCSLCGFNPNPHLT----------EVKEWLCLNCQMKRALGGDLAP 652

Query: 244  RPGLPGPE------HSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSV 297
             P  P P+       + S    SSP P  + SP  +   + +L+    P      ++   
Sbjct: 653  VPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-SPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711

Query: 298  EESTPISRETGEPYRLS-PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV 356
               +P ++    P   S  +P P  EP +  E   +    +       ++  T L S + 
Sbjct: 712  LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSS 771

Query: 357  EIHEPNGMVPSEDLEPEVE--SSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVD 414
               +P+  +PS  ++ + E  ++P L    A PS+S  P      P +  + A   PA D
Sbjct: 772  ATTKPD--IPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD--SKAIPRPASD 827

Query: 415  LSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQE-EEMEEEEEEEEGEAGEAGE 473
               +S P   ++        P      P  A +  SP  + + M +      G    AG+
Sbjct: 828  SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQ 887

Query: 474  AESEKGGEELLPPESTPIPANLSQ--NLEAAAATQVAVSVPKRRRK-------------I 518
                     +  P+ +P P   S+  +L   + T    S P   ++              
Sbjct: 888  T--------VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIF 939

Query: 519  KELNKKEAVGDLLDAFKEANPAVP----EVENQPPAGSNPGPESEGSGVPPRPEEADETW 574
             + +   +         ++ P  P       +QPP    P P+S G   PP P ++    
Sbjct: 940  SQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGP-PKSTGQ-APPAPAKSIPV- 996

Query: 575  DSKEDKIHNAENIQP 589
              KE K   AE ++P
Sbjct: 997  -KKETKAPAAEKLEP 1010



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 142/692 (20%), Positives = 239/692 (34%), Gaps = 132/692 (19%)

Query: 1    MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60
            ++KAP+   PPP     + QP    G  +      P+A  ++ P+ P++   PS      
Sbjct: 694  LSKAPEPKKPPPL----VKQPTLH-GSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAP 748

Query: 61   SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY 120
             A  + +     +P        + +    IPS  S   SQ         ++    P+Q +
Sbjct: 749  VADDKPKQPKMVKPTTDLVSSSSATTKPDIPS--SKVQSQAEEKTTPPLKTDSAKPSQSF 806

Query: 121  P-----VQPGAPGFYP-GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPP----- 169
            P     V P      P  AS ++  ++ G    ++G +Q        PV   + P     
Sbjct: 807  PPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVD------PVQKKEEPKKAQT 860

Query: 170  QIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLE------------- 216
            +++PK + K +    P   G   T          + PTP Q+    E             
Sbjct: 861  KMSPKPDAKPMPKGSPTPPGPRPT-------AGQTVPTPQQSPKPQEQSRRFSLNLGSIT 913

Query: 217  --PQANGETPQVAVIVR-----PDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPS 269
              P++   TPQ  V  +         SQ + +    G PGP        P   +P PS  
Sbjct: 914  DAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQP 973

Query: 270  PVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEV 329
            P  +            P  +      +  +S P+ +ET  P     EP     P ++   
Sbjct: 974  PTSQG-----------PPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTE 1022

Query: 330  TLSKPVP---ESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPAC 386
            T  KP P       ++ P +A  P         E    +   +L    +  P       C
Sbjct: 1023 TEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTEC 1082

Query: 387  PSE-------SPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPS 439
             ++       +P P     Q E L     +  A+          Q  ++      P+ P 
Sbjct: 1083 KNQVCNLCGFNPTPHLTEIQ-EWLCLNCQTQRAI--------SGQLGDIRKMPPAPSGPK 1133

Query: 440  ATPATAPSATS------PAQEEEMEEEEEEEEGEAGEA-GEAESEKGGEELLPPESTPIP 492
            A+P   P+ +S      P Q + ++++E+E + EA +   E   E    E +PP  T   
Sbjct: 1134 ASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQ 1193

Query: 493  ANLSQNLE--AAAATQVAVSVPKRRRKIKELNK--KEAVGDLLDAFK---EANPAVPEVE 545
                  LE   A+A Q    +P+ ++ I E  K   E    LL+  K   E    +PE +
Sbjct: 1194 KQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253

Query: 546  NQPP-----------------------------AGSNPGPESEG--SGVPPR-PEEADET 573
               P                              G  P  + EG  SG P   P+E D+T
Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313

Query: 574  WDSKEDK-----IHNAENIQPGEQKYEYKSDQ 600
              + +++         + ++PG++K E + D+
Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDK 1345



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 60/236 (25%), Positives = 85/236 (36%), Gaps = 40/236 (16%)

Query: 231  RPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTP-----SPSPVLEPGSEPNLAVLSI 285
            RP  RS    I+ +P  P P   P    P  P P P     SP P + P  +  L V S 
Sbjct: 2391 RPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILP--KKKLTVAS- 2447

Query: 286  PGDTMTTI--QMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSS 343
            P  T T +   ++  E+T + R  G              P+  +  T   PVP       
Sbjct: 2448 PVTTATPLFDAVTTLETTAVLRSNG-------------LPVTRICTTAPPPVPPK----- 2489

Query: 344  PLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPE-E 402
                P+ + S  V  H P    P    +P +   P     P      P  ++ T+     
Sbjct: 2490 ----PSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLN 2545

Query: 403  LLNGA----PSPPAVDLSPVSEPEEQ--AKEVTASMAPPTIPSATPATAPSATSPA 452
            L+  A    PSP +  LSP S       +K +T +    T+PS       S+ S A
Sbjct: 2546 LVTSADYKLPSPTS-PLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQA 2600


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 177/796 (22%), Positives = 269/796 (33%), Gaps = 141/796 (17%)

Query: 9    GPPPAPSPG----LPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA-- 62
            G PPA  PG     P PA PP Q  P   + P A Q  T   P Q   P   +PP+    
Sbjct: 312  GKPPAQQPGHEKSQPGPAKPPAQ--PSGLTKPLAQQPGTVKPPVQP--PGTTKPPAQPLG 367

Query: 63   -----ASRVQSAAPA--RPGPAAHVYPAGSQVMMIPSQISYPASQGAYYI---------P 106
                 A +  S  P+  +PGP A   P G  V   P+Q   PA      +         P
Sbjct: 368  PAKPPAQQTGSEKPSSEQPGPKALAQPPG--VGKTPAQQPGPAKPPTQQVGTPKPLAQQP 425

Query: 107  GQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMN 166
            G           + PVQ   PG  P        T A    P +   Q P    P P    
Sbjct: 426  GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPP---- 481

Query: 167  QPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQV 226
            Q P  A    ++    + P+Q             +  ST  PPQ  G  +P     +PQ 
Sbjct: 482  QQPGPAKPPPQQPGSAKPPSQ-------------QPGSTKPPPQQPGPAKP-----SPQQ 523

Query: 227  AVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIP 286
                +P  +        +PG   P  S  +  P+ PS   S  PV + GS          
Sbjct: 524  PGSTKPPSQ--------QPGSAKP--SAQQPSPAKPSAQQSTKPVSQTGS---------- 563

Query: 287  GDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVT--LSKPVPESEFSSSP 344
                           P+   T  P    P    L + I  +  T  L   VPE    ++ 
Sbjct: 564  -------------GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTC 610

Query: 345  LQAPTPLAS--------HTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES--PVPI 394
             +  T + S        H  E+ E   +    + + +     +LAP P+ P       P+
Sbjct: 611  TECQTTVCSLCGFNPNPHLTEVKEWLCL----NCQMKRALGGDLAPVPSSPQPKLKTAPV 666

Query: 395  APTA-------QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASM--APPTIPSATPATA 445
              T+       QP++      + P  DLS   EP++    V        P+  +  P  A
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726

Query: 446  PSATSPAQEEEMEEEEEEEEGEAGEAGEAESE--KGGEELLPPESTPIPANLSQNLEAAA 503
             S + PA  +E     E+++    +    + +  K   +L+   S     ++  +   + 
Sbjct: 727  DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQ 786

Query: 504  ATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGV 563
            A +   + P +    K        G+ +  F   + A+P   +     S+PGP SE  G 
Sbjct: 787  AEE-KTTPPLKTDSAKPSQSFPPTGEKVSPFD--SKAIPRPASDSKIISHPGPSSESKG- 842

Query: 564  PPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFI 623
                         + D +   E  +  + K   K D  KP+              G Q +
Sbjct: 843  -----------QKQVDPVQKKEEPKKAQTKMSPKPDA-KPMPKGSPTPPGPRPTAG-QTV 889

Query: 624  FASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGP--DFTPSFANLGRTTLSTR 681
                Q P+         L+  + T      PT  Q    G    F  S  +     +ST 
Sbjct: 890  PTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTA 949

Query: 682  GPP----RGGPGGELPRGPAGLGPRRSQQGPR---KEPRKIIATVLMTEDIKLNKAEK-- 732
            G P    + GPG  + + PA   P  SQ  P+   + P     ++ + ++ K   AEK  
Sbjct: 950  GQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLE 1009

Query: 733  ---AWKPSSKRTAADK 745
                  P+ KRT  +K
Sbjct: 1010 PKAEQAPTVKRTETEK 1025



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 129/619 (20%), Positives = 208/619 (33%), Gaps = 109/619 (17%)

Query: 5    PQSTGP--PPAPSPGLPQP-AFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSS 61
            PQ  GP  PP   PG  +P +  PG T P     PQ      PS  +       +Q P S
Sbjct: 481  PQQPGPAKPPPQQPGSAKPPSQQPGSTKP----PPQQPGPAKPSPQQPGSTKPPSQQPGS 536

Query: 62   AASRVQSAAPARPGPAAHVYP---AGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVP-- 116
            A    Q  +PA+P       P    GS   + P  +S  A Q     P QG    + P  
Sbjct: 537  AKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQP----PSQGLPKTICPLC 592

Query: 117  ------------------TQQYPVQPGAPGFYPGASPTEFGTYA---GAYYPAQGVQQFP 155
                              T+         GF P    TE   +         A G    P
Sbjct: 593  NTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAP 652

Query: 156  TGVAPAPVLMN--------------QPPQIAPKRE----RKTIRIRDPNQGGKDITEEIM 197
               +P P L                QP Q +PK++    +   +  +P +    + +  +
Sbjct: 653  VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTL 712

Query: 198  SGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSES 257
             G+ +A    PP+    L   A  + P V     P ++ +  +  D+P  P     P+  
Sbjct: 713  HGSPSAKAKQPPE-ADSLSKPAPPKEPSV-----PSEQDKAPVADDKPKQP-KMVKPTTD 765

Query: 258  QPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEEST--PISRETGEPYRLSP 315
              SS S T  P                IP    + +Q   EE T  P+  ++ +P +  P
Sbjct: 766  LVSSSSATTKP---------------DIPS---SKVQSQAEEKTTPPLKTDSAKPSQSFP 807

Query: 316  EPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVE 375
               P  E +   +   SK +P     S  +  P P    + E      + P +  E   +
Sbjct: 808  ---PTGEKVSPFD---SKAIPRPASDSKIISHPGP----SSESKGQKQVDPVQKKEEPKK 857

Query: 376  SSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPP 435
            +  +++P    P   P+P      P        + P    SP  +P+EQ++  + ++   
Sbjct: 858  AQTKMSPK---PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP--KPQEQSRRFSLNLGSI 912

Query: 436  TIPSATPATAPSATSPAQ----EEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI 491
            T    +  T P  T   +       +  +       AG+ G       G    P +  P 
Sbjct: 913  TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG---APMKQAPA 969

Query: 492  PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAG 551
            P+    +     +T  A   P +   +K+  K  A  + L+   E  P V   E +    
Sbjct: 970  PSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPA-AEKLEPKAEQAPTVKRTETE---- 1024

Query: 552  SNPGPESEGSGVPPRPEEA 570
              P P  +   +   P++A
Sbjct: 1025 KKPPPIKDSKSLTAEPQKA 1043



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 98/404 (24%), Positives = 148/404 (36%), Gaps = 88/404 (21%)

Query: 149 QGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTP 208
           Q  Q  P G+   P L  QPP+  PK++      RDP Q  +D T + +S  +     + 
Sbjct: 197 QKEQGKPEGIIKPP-LQQQPPKPIPKQQGPG---RDPLQ--QDGTPKSISSQQPEKIKSQ 250

Query: 209 PQTGGGLEPQANGETPQVAVIVRPDDRS-------QGAIIAD---RPGLPGPEHSPSESQ 258
           P  G G   Q   +TPQ      P  R        Q  I+     +P LP P      S+
Sbjct: 251 PP-GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSP------SK 303

Query: 259 PSSPSPTPSPSPVLEPG---SEPNLA------------VLSIPGDTMTTIQ--------- 294
           P    PTP   P  +PG   S+P  A            +   PG     +Q         
Sbjct: 304 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA 363

Query: 295 MSVEESTPISRETG--EPYRLSPEPTPLAEP---------------ILEVEVTLSKPVPE 337
             +  + P +++TG  +P    P P  LA+P                   +V   KP+ +
Sbjct: 364 QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ 423

Query: 338 SEFSSSPLQAPTPLASHTVEIHEPN-GMVPSEDLEPEVESSPELAPPPACPSESPVPIAP 396
                SP +AP P  +    + +P  G +P++   P   S+ +  P    PS+ P P  P
Sbjct: 424 QPGLQSPAKAPGPTKT---PVQQPGPGKIPAQQAGPGKTSAQQTGPTKP-PSQLPGPAKP 479

Query: 397 ------TAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPP---TIPSATPATA-P 446
                  A+P     G+  PP+        P +Q      S   P     PS  P +A P
Sbjct: 480 PPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP 539

Query: 447 SATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTP 490
           SA  P+  +   ++  +   + G          G+ L PP  +P
Sbjct: 540 SAQQPSPAKPSAQQSTKPVSQTG---------SGKPLQPPTVSP 574



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 132/615 (21%), Positives = 206/615 (33%), Gaps = 97/615 (15%)

Query: 6    QSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASR 65
            Q TGP   PS  LP PA PP Q        PQ        QP     PS  Q P S    
Sbjct: 462  QQTGPTKPPSQ-LPGPAKPPPQQPGPAKPPPQ--------QPGSAKPPS--QQPGSTKPP 510

Query: 66   VQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPG 125
             Q   PA+P P              P     P+ Q     PG  +     P+ Q P  P 
Sbjct: 511  PQQPGPAKPSPQQ------------PGSTKPPSQQ-----PGSAK-----PSAQQP-SPA 547

Query: 126  APGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDP 185
             P       P    +  G+  P Q     P+  A  P     P  I P      + +  P
Sbjct: 548  KPSAQQSTKPV---SQTGSGKPLQPPTVSPS--AKQPPSQGLPKTICPLCNTTELLLHVP 602

Query: 186  NQGGKDITEEIMSG--ARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIAD 243
             +   +   E  +   +     P P  T          E  +   +     R+ G  +A 
Sbjct: 603  EKANFNTCTECQTTVCSLCGFNPNPHLT----------EVKEWLCLNCQMKRALGGDLAP 652

Query: 244  RPGLPGPE------HSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSV 297
             P  P P+       + S    SSP P  + SP  +   + +L+    P      ++   
Sbjct: 653  VPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-SPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711

Query: 298  EESTPISRETGEPYRLS-PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV 356
               +P ++    P   S  +P P  EP +  E   +    +       ++  T L S + 
Sbjct: 712  LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSS 771

Query: 357  EIHEPNGMVPSEDLEPEVE--SSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVD 414
               +P+  +PS  ++ + E  ++P L    A PS+S  P      P +  + A   PA D
Sbjct: 772  ATTKPD--IPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD--SKAIPRPASD 827

Query: 415  LSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQE-EEMEEEEEEEEGEAGEAGE 473
               +S P   ++        P      P  A +  SP  + + M +      G    AG+
Sbjct: 828  SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQ 887

Query: 474  AESEKGGEELLPPESTPIPANLSQ--NLEAAAATQVAVSVPKRRRK-------------I 518
                     +  P+ +P P   S+  +L   + T    S P   ++              
Sbjct: 888  T--------VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIF 939

Query: 519  KELNKKEAVGDLLDAFKEANPAVP----EVENQPPAGSNPGPESEGSGVPPRPEEADETW 574
             + +   +         ++ P  P       +QPP    P P+S G   PP P ++    
Sbjct: 940  SQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGP-PKSTGQ-APPAPAKSIPV- 996

Query: 575  DSKEDKIHNAENIQP 589
              KE K   AE ++P
Sbjct: 997  -KKETKAPAAEKLEP 1010



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 142/692 (20%), Positives = 239/692 (34%), Gaps = 132/692 (19%)

Query: 1    MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60
            ++KAP+   PPP     + QP    G  +      P+A  ++ P+ P++   PS      
Sbjct: 694  LSKAPEPKKPPPL----VKQPTLH-GSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAP 748

Query: 61   SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY 120
             A  + +     +P        + +    IPS  S   SQ         ++    P+Q +
Sbjct: 749  VADDKPKQPKMVKPTTDLVSSSSATTKPDIPS--SKVQSQAEEKTTPPLKTDSAKPSQSF 806

Query: 121  P-----VQPGAPGFYP-GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPP----- 169
            P     V P      P  AS ++  ++ G    ++G +Q        PV   + P     
Sbjct: 807  PPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVD------PVQKKEEPKKAQT 860

Query: 170  QIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLE------------- 216
            +++PK + K +    P   G   T          + PTP Q+    E             
Sbjct: 861  KMSPKPDAKPMPKGSPTPPGPRPT-------AGQTVPTPQQSPKPQEQSRRFSLNLGSIT 913

Query: 217  --PQANGETPQVAVIVR-----PDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPS 269
              P++   TPQ  V  +         SQ + +    G PGP        P   +P PS  
Sbjct: 914  DAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQP 973

Query: 270  PVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEV 329
            P  +            P  +      +  +S P+ +ET  P     EP     P ++   
Sbjct: 974  PTSQG-----------PPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTE 1022

Query: 330  TLSKPVP---ESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPAC 386
            T  KP P       ++ P +A  P         E    +   +L    +  P       C
Sbjct: 1023 TEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTEC 1082

Query: 387  PSE-------SPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPS 439
             ++       +P P     Q E L     +  A+          Q  ++      P+ P 
Sbjct: 1083 KNQVCNLCGFNPTPHLTEIQ-EWLCLNCQTQRAI--------SGQLGDIRKMPPAPSGPK 1133

Query: 440  ATPATAPSATS------PAQEEEMEEEEEEEEGEAGEA-GEAESEKGGEELLPPESTPIP 492
            A+P   P+ +S      P Q + ++++E+E + EA +   E   E    E +PP  T   
Sbjct: 1134 ASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQ 1193

Query: 493  ANLSQNLE--AAAATQVAVSVPKRRRKIKELNK--KEAVGDLLDAFK---EANPAVPEVE 545
                  LE   A+A Q    +P+ ++ I E  K   E    LL+  K   E    +PE +
Sbjct: 1194 KQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253

Query: 546  NQPP-----------------------------AGSNPGPESEG--SGVPPR-PEEADET 573
               P                              G  P  + EG  SG P   P+E D+T
Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313

Query: 574  WDSKEDK-----IHNAENIQPGEQKYEYKSDQ 600
              + +++         + ++PG++K E + D+
Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDK 1345



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 60/236 (25%), Positives = 85/236 (36%), Gaps = 40/236 (16%)

Query: 231  RPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTP-----SPSPVLEPGSEPNLAVLSI 285
            RP  RS    I+ +P  P P   P    P  P P P     SP P + P  +  L V S 
Sbjct: 2391 RPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILP--KKKLTVAS- 2447

Query: 286  PGDTMTTI--QMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSS 343
            P  T T +   ++  E+T + R  G              P+  +  T   PVP       
Sbjct: 2448 PVTTATPLFDAVTTLETTAVLRSNG-------------LPVTRICTTAPPPVPPK----- 2489

Query: 344  PLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPE-E 402
                P+ + S  V  H P    P    +P +   P     P      P  ++ T+     
Sbjct: 2490 ----PSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLN 2545

Query: 403  LLNGA----PSPPAVDLSPVSEPEEQ--AKEVTASMAPPTIPSATPATAPSATSPA 452
            L+  A    PSP +  LSP S       +K +T +    T+PS       S+ S A
Sbjct: 2546 LVTSADYKLPSPTS-PLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQA 2600


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/579 (21%), Positives = 171/579 (29%), Gaps = 67/579 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQ---HFYPSRAQPP 59
           KA  +T  P   +P  P P            +TP+     TP +P        P+  + P
Sbjct: 200 KAETTTKGPALTTPKEPTP------------TTPKEPASTTPKEPTPTTIKSAPTTPKEP 247

Query: 60  SSAASRVQSAAPARPGPAAHVYPAGSQVM-MIPSQISYPASQGAYYIPGQGRSTYVVPTQ 118
           +   ++     P  P P     PA +      P+    PA       P   +S    P +
Sbjct: 248 APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA-------PTTTKSAPTTPKE 300

Query: 119 QYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERK 178
             P  P  P   P        T      P    +  PT   PAP    +P   APK+   
Sbjct: 301 PAPTTPKKPA--PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 358

Query: 179 TIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQG 238
           T     P +      +E         +PT P+      P      P       P      
Sbjct: 359 T----TPKEPAPTTPKEPAPTTTKEPSPTTPKEPA---PTTTKSAPTTTKEPAPTTTKSA 411

Query: 239 AIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVE 298
                 P  P     P+ + P  P+PT    P      EP       P  T T       
Sbjct: 412 PTTPKEPS-PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTT------- 463

Query: 299 ESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
              P      EP   +P+ T    P      T  K  P +    +P   P  LA  T E 
Sbjct: 464 -KKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTPEELAPTTPE- 520

Query: 359 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
            EP    P E         P    P A    +P   APT  P+E     P  PA      
Sbjct: 521 -EPTPTTPEE---------PAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPA-----P 564

Query: 419 SEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEK 478
           + P+E A       AP T+    P T      PA +E      +E      +     + K
Sbjct: 565 TTPKETAPTTPKGTAPTTLKEPAPTT---PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 621

Query: 479 GGEELLPPESTPI----PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAF 534
           G     P E  P     PA  +    A    +       ++   KEL      G      
Sbjct: 622 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 681

Query: 535 KEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADET 573
            +  P  P+ E  P     P P +     P  PE    T
Sbjct: 682 DKPAPTTPK-ETAPTTPKEPAPTTPKKPAPTTPETPPPT 719



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 125/598 (20%), Positives = 187/598 (31%), Gaps = 67/598 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
           K+  +T   PAP+     P  P  + AP     P  T   TP +P     P+  + P+  
Sbjct: 238 KSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEPAPT---TPKEPA----PTTTKEPAPT 289

Query: 63  ASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPV 122
            ++     P  P P     PA       P+    PA            +T   PT   P 
Sbjct: 290 TTKSAPTTPKEPAPTTPKKPA-------PTTPKEPAP-----------TTPKEPTPTTPK 331

Query: 123 QPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFP---TGVAPAPVLMNQPPQIAPKRERKT 179
           +P      P  +  +         PA    + P   T   PAP    +P    PK    T
Sbjct: 332 EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 391

Query: 180 IRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGA 239
                P    +       S   T   P+P  T            P       P    + A
Sbjct: 392 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 451

Query: 240 IIADRPGLPGPEHSPSESQPSSPSPT------PSPSPVLEPGSEPNLAVLSIPGDTMTTI 293
               +   P     P+ + P  P+PT      P+    L P +   LA  +      TT 
Sbjct: 452 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTT- 510

Query: 294 QMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPL--QAPTPL 351
               EE  P + E  EP   +PE      P      T  +P P +    +P   + P P 
Sbjct: 511 ---PEELAPTTPE--EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 565

Query: 352 ASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPP 411
                    P G  P+   EP   +  + AP    P+ +  P + T          P+P 
Sbjct: 566 TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD-------KPAPT 618

Query: 412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPAT--APSATSPAQEEEMEEEEEEEEGEAG 469
               +  + P+E A       AP T     P T   P+ T+P +    E      +G   
Sbjct: 619 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 678

Query: 470 EAGEAESEKGGEELLP-----PESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK 524
              +  +    +E  P     P  T          E    T   VS P   ++   ++K 
Sbjct: 679 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKS 738

Query: 525 --EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDK 580
             E+  +L      A P    +EN P     PG  +  +    +PE      D   ++
Sbjct: 739 PDESTPEL-----SAEPTPKALENSP---KEPGVPTTKTPAATKPEMTTTAKDKTTER 788



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 89/418 (21%), Positives = 139/418 (33%), Gaps = 76/418 (18%)

Query: 205 TPTPP---QTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSS 261
           TP PP   + G GL+   NG+      +  PD  +              +H+   + P  
Sbjct: 79  TPKPPVVDEAGSGLD---NGDFK----VTTPDTSTT-------------QHNKVSTSPKI 118

Query: 262 PSPTP-SPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPL 320
            +  P +P P L P S+ +    S+  +  TT++   +E+T  +++T    +   E T  
Sbjct: 119 TTAKPINPRPSLPPNSDTSKET-SLTVNKETTVE--TKETTTTNKQTSTDGK---EKTTS 172

Query: 321 AEPILEVEVT-----------LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 369
           A+    +E T           L+KP P++E ++      TP         EP    P E 
Sbjct: 173 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEP 232

Query: 370 LEPEVESSPELAPPPACPSESPVPIAP-------TAQPEELLNGAPSP-------PAVDL 415
               ++S+P     PA  +    P  P       T +P       P+P       P    
Sbjct: 233 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 292

Query: 416 SPVSEPEEQAKEVTASMAP-------PTIPSATPATAPSATSPAQEEEMEEEEEEEEGEA 468
           S  + P+E A       AP       PT P     T P   +P  +E      +E    A
Sbjct: 293 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 352

Query: 469 GEAGEAESEKGGEELLPPESTP---------IPANLSQNLEAAAATQVAVSVPKRRRKIK 519
            +     + K      P E  P          P   +     +A T      P   +   
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 412

Query: 520 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSK 577
              K+ +        KE  P  P+ E  P     P P +     P  P+E   T   K
Sbjct: 413 TTPKEPSP----TTTKEPAPTTPK-EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/579 (21%), Positives = 171/579 (29%), Gaps = 67/579 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQ---HFYPSRAQPP 59
           KA  +T  P   +P  P P            +TP+     TP +P        P+  + P
Sbjct: 241 KAETTTKGPALTTPKEPTP------------TTPKEPASTTPKEPTPTTIKSAPTTPKEP 288

Query: 60  SSAASRVQSAAPARPGPAAHVYPAGSQVM-MIPSQISYPASQGAYYIPGQGRSTYVVPTQ 118
           +   ++     P  P P     PA +      P+    PA       P   +S    P +
Sbjct: 289 APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA-------PTTTKSAPTTPKE 341

Query: 119 QYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERK 178
             P  P  P   P        T      P    +  PT   PAP    +P   APK+   
Sbjct: 342 PAPTTPKKPA--PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 399

Query: 179 TIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQG 238
           T     P +      +E         +PT P+      P      P       P      
Sbjct: 400 T----TPKEPAPTTPKEPAPTTTKEPSPTTPKEPA---PTTTKSAPTTTKEPAPTTTKSA 452

Query: 239 AIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVE 298
                 P  P     P+ + P  P+PT    P      EP       P  T T       
Sbjct: 453 PTTPKEPS-PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTT------- 504

Query: 299 ESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
              P      EP   +P+ T    P      T  K  P +    +P   P  LA  T E 
Sbjct: 505 -KKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTPEELAPTTPE- 561

Query: 359 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
            EP    P E         P    P A    +P   APT  P+E     P  PA      
Sbjct: 562 -EPTPTTPEE---------PAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPA-----P 605

Query: 419 SEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEK 478
           + P+E A       AP T+    P T      PA +E      +E      +     + K
Sbjct: 606 TTPKETAPTTPKGTAPTTLKEPAPTT---PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 662

Query: 479 GGEELLPPESTPI----PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAF 534
           G     P E  P     PA  +    A    +       ++   KEL      G      
Sbjct: 663 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 722

Query: 535 KEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADET 573
            +  P  P+ E  P     P P +     P  PE    T
Sbjct: 723 DKPAPTTPK-ETAPTTPKEPAPTTPKKPAPTTPETPPPT 760



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 125/598 (20%), Positives = 187/598 (31%), Gaps = 67/598 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
           K+  +T   PAP+     P  P  + AP     P  T   TP +P     P+  + P+  
Sbjct: 279 KSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEPAPT---TPKEPA----PTTTKEPAPT 330

Query: 63  ASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPV 122
            ++     P  P P     PA       P+    PA            +T   PT   P 
Sbjct: 331 TTKSAPTTPKEPAPTTPKKPA-------PTTPKEPAP-----------TTPKEPTPTTPK 372

Query: 123 QPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFP---TGVAPAPVLMNQPPQIAPKRERKT 179
           +P      P  +  +         PA    + P   T   PAP    +P    PK    T
Sbjct: 373 EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 432

Query: 180 IRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGA 239
                P    +       S   T   P+P  T            P       P    + A
Sbjct: 433 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 492

Query: 240 IIADRPGLPGPEHSPSESQPSSPSPT------PSPSPVLEPGSEPNLAVLSIPGDTMTTI 293
               +   P     P+ + P  P+PT      P+    L P +   LA  +      TT 
Sbjct: 493 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTT- 551

Query: 294 QMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPL--QAPTPL 351
               EE  P + E  EP   +PE      P      T  +P P +    +P   + P P 
Sbjct: 552 ---PEELAPTTPE--EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 606

Query: 352 ASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPP 411
                    P G  P+   EP   +  + AP    P+ +  P + T          P+P 
Sbjct: 607 TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD-------KPAPT 659

Query: 412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPAT--APSATSPAQEEEMEEEEEEEEGEAG 469
               +  + P+E A       AP T     P T   P+ T+P +    E      +G   
Sbjct: 660 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 719

Query: 470 EAGEAESEKGGEELLP-----PESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK 524
              +  +    +E  P     P  T          E    T   VS P   ++   ++K 
Sbjct: 720 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKS 779

Query: 525 --EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDK 580
             E+  +L      A P    +EN P     PG  +  +    +PE      D   ++
Sbjct: 780 PDESTPEL-----SAEPTPKALENSP---KEPGVPTTKTPAATKPEMTTTAKDKTTER 829



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 89/418 (21%), Positives = 139/418 (33%), Gaps = 76/418 (18%)

Query: 205 TPTPP---QTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSS 261
           TP PP   + G GL+   NG+      +  PD  +              +H+   + P  
Sbjct: 120 TPKPPVVDEAGSGLD---NGDFK----VTTPDTSTT-------------QHNKVSTSPKI 159

Query: 262 PSPTP-SPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPL 320
            +  P +P P L P S+ +    S+  +  TT++   +E+T  +++T    +   E T  
Sbjct: 160 TTAKPINPRPSLPPNSDTSKET-SLTVNKETTVE--TKETTTTNKQTSTDGK---EKTTS 213

Query: 321 AEPILEVEVT-----------LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 369
           A+    +E T           L+KP P++E ++      TP         EP    P E 
Sbjct: 214 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEP 273

Query: 370 LEPEVESSPELAPPPACPSESPVPIAP-------TAQPEELLNGAPSP-------PAVDL 415
               ++S+P     PA  +    P  P       T +P       P+P       P    
Sbjct: 274 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 333

Query: 416 SPVSEPEEQAKEVTASMAP-------PTIPSATPATAPSATSPAQEEEMEEEEEEEEGEA 468
           S  + P+E A       AP       PT P     T P   +P  +E      +E    A
Sbjct: 334 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 393

Query: 469 GEAGEAESEKGGEELLPPESTP---------IPANLSQNLEAAAATQVAVSVPKRRRKIK 519
            +     + K      P E  P          P   +     +A T      P   +   
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 453

Query: 520 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSK 577
              K+ +        KE  P  P+ E  P     P P +     P  P+E   T   K
Sbjct: 454 TTPKEPSP----TTTKEPAPTTPK-EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/579 (21%), Positives = 171/579 (29%), Gaps = 67/579 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQ---HFYPSRAQPP 59
           KA  +T  P   +P  P P            +TP+     TP +P        P+  + P
Sbjct: 293 KAETTTKGPALTTPKEPTP------------TTPKEPASTTPKEPTPTTIKSAPTTPKEP 340

Query: 60  SSAASRVQSAAPARPGPAAHVYPAGSQVM-MIPSQISYPASQGAYYIPGQGRSTYVVPTQ 118
           +   ++     P  P P     PA +      P+    PA       P   +S    P +
Sbjct: 341 APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA-------PTTTKSAPTTPKE 393

Query: 119 QYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERK 178
             P  P  P   P        T      P    +  PT   PAP    +P   APK+   
Sbjct: 394 PAPTTPKKPA--PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 451

Query: 179 TIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQG 238
           T     P +      +E         +PT P+      P      P       P      
Sbjct: 452 T----TPKEPAPTTPKEPAPTTTKEPSPTTPKEPA---PTTTKSAPTTTKEPAPTTTKSA 504

Query: 239 AIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVE 298
                 P  P     P+ + P  P+PT    P      EP       P  T T       
Sbjct: 505 PTTPKEPS-PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTT------- 556

Query: 299 ESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
              P      EP   +P+ T    P      T  K  P +    +P   P  LA  T E 
Sbjct: 557 -KKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTPEELAPTTPE- 613

Query: 359 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
            EP    P E         P    P A    +P   APT  P+E     P  PA      
Sbjct: 614 -EPTPTTPEE---------PAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPA-----P 657

Query: 419 SEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEK 478
           + P+E A       AP T+    P T      PA +E      +E      +     + K
Sbjct: 658 TTPKETAPTTPKGTAPTTLKEPAPTT---PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 714

Query: 479 GGEELLPPESTPI----PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAF 534
           G     P E  P     PA  +    A    +       ++   KEL      G      
Sbjct: 715 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 774

Query: 535 KEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADET 573
            +  P  P+ E  P     P P +     P  PE    T
Sbjct: 775 DKPAPTTPK-ETAPTTPKEPAPTTPKKPAPTTPETPPPT 812



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 125/598 (20%), Positives = 187/598 (31%), Gaps = 67/598 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
           K+  +T   PAP+     P  P  + AP     P  T   TP +P     P+  + P+  
Sbjct: 331 KSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEPAPT---TPKEPA----PTTTKEPAPT 382

Query: 63  ASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPV 122
            ++     P  P P     PA       P+    PA            +T   PT   P 
Sbjct: 383 TTKSAPTTPKEPAPTTPKKPA-------PTTPKEPAP-----------TTPKEPTPTTPK 424

Query: 123 QPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFP---TGVAPAPVLMNQPPQIAPKRERKT 179
           +P      P  +  +         PA    + P   T   PAP    +P    PK    T
Sbjct: 425 EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 484

Query: 180 IRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGA 239
                P    +       S   T   P+P  T            P       P    + A
Sbjct: 485 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 544

Query: 240 IIADRPGLPGPEHSPSESQPSSPSPT------PSPSPVLEPGSEPNLAVLSIPGDTMTTI 293
               +   P     P+ + P  P+PT      P+    L P +   LA  +      TT 
Sbjct: 545 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTT- 603

Query: 294 QMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPL--QAPTPL 351
               EE  P + E  EP   +PE      P      T  +P P +    +P   + P P 
Sbjct: 604 ---PEELAPTTPE--EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 658

Query: 352 ASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPP 411
                    P G  P+   EP   +  + AP    P+ +  P + T          P+P 
Sbjct: 659 TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD-------KPAPT 711

Query: 412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPAT--APSATSPAQEEEMEEEEEEEEGEAG 469
               +  + P+E A       AP T     P T   P+ T+P +    E      +G   
Sbjct: 712 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 771

Query: 470 EAGEAESEKGGEELLP-----PESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK 524
              +  +    +E  P     P  T          E    T   VS P   ++   ++K 
Sbjct: 772 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKS 831

Query: 525 --EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDK 580
             E+  +L      A P    +EN P     PG  +  +    +PE      D   ++
Sbjct: 832 PDESTPEL-----SAEPTPKALENSP---KEPGVPTTKTPAATKPEMTTTAKDKTTER 881



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 89/418 (21%), Positives = 139/418 (33%), Gaps = 76/418 (18%)

Query: 205 TPTPP---QTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSS 261
           TP PP   + G GL+   NG+      +  PD  +              +H+   + P  
Sbjct: 172 TPKPPVVDEAGSGLD---NGDFK----VTTPDTSTT-------------QHNKVSTSPKI 211

Query: 262 PSPTP-SPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPL 320
            +  P +P P L P S+ +    S+  +  TT++   +E+T  +++T    +   E T  
Sbjct: 212 TTAKPINPRPSLPPNSDTSKET-SLTVNKETTVE--TKETTTTNKQTSTDGK---EKTTS 265

Query: 321 AEPILEVEVT-----------LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 369
           A+    +E T           L+KP P++E ++      TP         EP    P E 
Sbjct: 266 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEP 325

Query: 370 LEPEVESSPELAPPPACPSESPVPIAP-------TAQPEELLNGAPSP-------PAVDL 415
               ++S+P     PA  +    P  P       T +P       P+P       P    
Sbjct: 326 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 385

Query: 416 SPVSEPEEQAKEVTASMAP-------PTIPSATPATAPSATSPAQEEEMEEEEEEEEGEA 468
           S  + P+E A       AP       PT P     T P   +P  +E      +E    A
Sbjct: 386 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 445

Query: 469 GEAGEAESEKGGEELLPPESTP---------IPANLSQNLEAAAATQVAVSVPKRRRKIK 519
            +     + K      P E  P          P   +     +A T      P   +   
Sbjct: 446 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 505

Query: 520 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSK 577
              K+ +        KE  P  P+ E  P     P P +     P  P+E   T   K
Sbjct: 506 TTPKEPSP----TTTKEPAPTTPK-EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/579 (21%), Positives = 171/579 (29%), Gaps = 67/579 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQ---HFYPSRAQPP 59
           KA  +T  P   +P  P P            +TP+     TP +P        P+  + P
Sbjct: 334 KAETTTKGPALTTPKEPTP------------TTPKEPASTTPKEPTPTTIKSAPTTPKEP 381

Query: 60  SSAASRVQSAAPARPGPAAHVYPAGSQVM-MIPSQISYPASQGAYYIPGQGRSTYVVPTQ 118
           +   ++     P  P P     PA +      P+    PA       P   +S    P +
Sbjct: 382 APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA-------PTTTKSAPTTPKE 434

Query: 119 QYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERK 178
             P  P  P   P        T      P    +  PT   PAP    +P   APK+   
Sbjct: 435 PAPTTPKKPA--PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 492

Query: 179 TIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQG 238
           T     P +      +E         +PT P+      P      P       P      
Sbjct: 493 T----TPKEPAPTTPKEPAPTTTKEPSPTTPKEPA---PTTTKSAPTTTKEPAPTTTKSA 545

Query: 239 AIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVE 298
                 P  P     P+ + P  P+PT    P      EP       P  T T       
Sbjct: 546 PTTPKEPS-PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTT------- 597

Query: 299 ESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
              P      EP   +P+ T    P      T  K  P +    +P   P  LA  T E 
Sbjct: 598 -KKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTPEELAPTTPE- 654

Query: 359 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
            EP    P E         P    P A    +P   APT  P+E     P  PA      
Sbjct: 655 -EPTPTTPEE---------PAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPA-----P 698

Query: 419 SEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEK 478
           + P+E A       AP T+    P T      PA +E      +E      +     + K
Sbjct: 699 TTPKETAPTTPKGTAPTTLKEPAPTT---PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 755

Query: 479 GGEELLPPESTPI----PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAF 534
           G     P E  P     PA  +    A    +       ++   KEL      G      
Sbjct: 756 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 815

Query: 535 KEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADET 573
            +  P  P+ E  P     P P +     P  PE    T
Sbjct: 816 DKPAPTTPK-ETAPTTPKEPAPTTPKKPAPTTPETPPPT 853



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 125/598 (20%), Positives = 187/598 (31%), Gaps = 67/598 (11%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
           K+  +T   PAP+     P  P  + AP     P  T   TP +P     P+  + P+  
Sbjct: 372 KSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEPAPT---TPKEPA----PTTTKEPAPT 423

Query: 63  ASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPV 122
            ++     P  P P     PA       P+    PA            +T   PT   P 
Sbjct: 424 TTKSAPTTPKEPAPTTPKKPA-------PTTPKEPAP-----------TTPKEPTPTTPK 465

Query: 123 QPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFP---TGVAPAPVLMNQPPQIAPKRERKT 179
           +P      P  +  +         PA    + P   T   PAP    +P    PK    T
Sbjct: 466 EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 525

Query: 180 IRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGA 239
                P    +       S   T   P+P  T            P       P    + A
Sbjct: 526 TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 585

Query: 240 IIADRPGLPGPEHSPSESQPSSPSPT------PSPSPVLEPGSEPNLAVLSIPGDTMTTI 293
               +   P     P+ + P  P+PT      P+    L P +   LA  +      TT 
Sbjct: 586 PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTT- 644

Query: 294 QMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPL--QAPTPL 351
               EE  P + E  EP   +PE      P      T  +P P +    +P   + P P 
Sbjct: 645 ---PEELAPTTPE--EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 699

Query: 352 ASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPP 411
                    P G  P+   EP   +  + AP    P+ +  P + T          P+P 
Sbjct: 700 TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD-------KPAPT 752

Query: 412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPAT--APSATSPAQEEEMEEEEEEEEGEAG 469
               +  + P+E A       AP T     P T   P+ T+P +    E      +G   
Sbjct: 753 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 812

Query: 470 EAGEAESEKGGEELLP-----PESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKK 524
              +  +    +E  P     P  T          E    T   VS P   ++   ++K 
Sbjct: 813 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKS 872

Query: 525 --EAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDK 580
             E+  +L      A P    +EN P     PG  +  +    +PE      D   ++
Sbjct: 873 PDESTPEL-----SAEPTPKALENSP---KEPGVPTTKTPAATKPEMTTTAKDKTTER 922



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 89/418 (21%), Positives = 139/418 (33%), Gaps = 76/418 (18%)

Query: 205 TPTPP---QTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSS 261
           TP PP   + G GL+   NG+      +  PD  +              +H+   + P  
Sbjct: 213 TPKPPVVDEAGSGLD---NGDFK----VTTPDTSTT-------------QHNKVSTSPKI 252

Query: 262 PSPTP-SPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPL 320
            +  P +P P L P S+ +    S+  +  TT++   +E+T  +++T    +   E T  
Sbjct: 253 TTAKPINPRPSLPPNSDTSKET-SLTVNKETTVE--TKETTTTNKQTSTDGK---EKTTS 306

Query: 321 AEPILEVEVT-----------LSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 369
           A+    +E T           L+KP P++E ++      TP         EP    P E 
Sbjct: 307 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEP 366

Query: 370 LEPEVESSPELAPPPACPSESPVPIAP-------TAQPEELLNGAPSP-------PAVDL 415
               ++S+P     PA  +    P  P       T +P       P+P       P    
Sbjct: 367 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 426

Query: 416 SPVSEPEEQAKEVTASMAP-------PTIPSATPATAPSATSPAQEEEMEEEEEEEEGEA 468
           S  + P+E A       AP       PT P     T P   +P  +E      +E    A
Sbjct: 427 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 486

Query: 469 GEAGEAESEKGGEELLPPESTP---------IPANLSQNLEAAAATQVAVSVPKRRRKIK 519
            +     + K      P E  P          P   +     +A T      P   +   
Sbjct: 487 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 546

Query: 520 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSK 577
              K+ +        KE  P  P+ E  P     P P +     P  P+E   T   K
Sbjct: 547 TTPKEPSP----TTTKEPAPTTPK-EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 130/519 (25%), Positives = 192/519 (36%), Gaps = 69/519 (13%)

Query: 1   MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS 60
           + ++P S      PSP L  P  PP + +P+   +P   +  +P  P     P+   P +
Sbjct: 515 LEESPLSPPEESPPSPALETPLSPPPEASPL---SPPFEE--SPLSPPPEELPTSPPPEA 569

Query: 61  SAASRVQSAAPARPGP----------AAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGR 110
           S  S     +P  P P          A+ ++P   +  + P     P S      P    
Sbjct: 570 SRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLS------PPPEA 623

Query: 111 STYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQ 170
           S    P +  P+ P  P   P + P E    +    P   V +       +P  ++ PP+
Sbjct: 624 SRLSPPPEDSPMSP-PPEESPMSPPPEVSRLS----PLPVVSRLSPPPEESP--LSPPPE 676

Query: 171 IAPKRER-KTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVI 229
            +P     +  R+  P        E+  +      +P  P     L      E+P + + 
Sbjct: 677 ESPTSPPPEASRLSPP-------PEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLP 729

Query: 230 VRPD--DRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPG 287
             P    RS+G  ++ RP  P     P E   S  +  P  SP  E   EP L   ++P 
Sbjct: 730 EEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPE---EPCLC--AVPE 784

Query: 288 DTMTTIQMSVEESTP------ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFS 341
           +   + Q      +P      +S +T EP+ LSP P    EP L  +   S   P+SE  
Sbjct: 785 EPHLSPQAEGPHLSPQPEELHLSPQTEEPH-LSPVPE---EPCLSPQPEESHLSPQSE-- 838

Query: 342 SSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVES---SPE---LAPPPACPSESPVPIA 395
             P  +P P  SH     E   + P  +  PE      +PE   L PPP  PS SP+   
Sbjct: 839 -EPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGE 897

Query: 396 PTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEE 455
           P          +P P  + LSP  EP    + +     PP +     A AP A SP  E 
Sbjct: 898 PALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGEL 957

Query: 456 EMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPAN 494
           E         G  G++ + ES      L  P S P  AN
Sbjct: 958 EY------PFGAKGDS-DPESPLAAPILETPISPPPEAN 989



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 104/403 (25%), Positives = 146/403 (36%), Gaps = 69/403 (17%)

Query: 187 QGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPG 246
           QGG+ I           S  +PP+ G         + P    +        G + + +P 
Sbjct: 353 QGGQTIRSVAEQHTPVCSRFSPPEPG-----DTPTDEPDALYVACQGQPKGGHVTSMQPK 407

Query: 247 LPGP---EHSPS-----ESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVE 298
            PGP   E  P      + +P   +P     P+L P   P  + LS P            
Sbjct: 408 EPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPP---PEESPLSPP-----------P 453

Query: 299 ESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPT--PLASHTV 356
           E +P S    E  RLSP P  L    L   + LS+P+ ES  S  P ++P   P  S   
Sbjct: 454 EESPTSPPP-EASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPF 512

Query: 357 EIHEPNGMVPSEDLEPEVESSPELAPPP-ACPSESPVPIAPTAQPEELLNGAPSPPAVDL 415
              E + + P E+  P       L+PPP A P   P   +P + P E L  +P P A  L
Sbjct: 513 SPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRL 572

Query: 416 SPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS----PAQEEEMEEEEEEEEGEAGEA 471
           SP   PEE      + M+PP  P  +P + P   S    P +E  +    EE        
Sbjct: 573 SP--PPEE------SPMSPP--PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPE 622

Query: 472 GEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLL 531
               S        PPE +P+         +    +  +S P    ++  L     V   L
Sbjct: 623 ASRLSP-------PPEDSPM---------SPPPEESPMSPPPEVSRLSPL----PVVSRL 662

Query: 532 DAFKEANPAVPEVENQP----PAGSNPGPESEGSGVPPRPEEA 570
               E +P  P  E  P    P  S   P  E S   P PE++
Sbjct: 663 SPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDS 705



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 100/392 (25%), Positives = 139/392 (35%), Gaps = 44/392 (11%)

Query: 205 TPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHS----PSESQPS 260
           T   P+  G L+ +A    P     V+ + + +  +  + P LP PE S    P E  P+
Sbjct: 402 TSMQPKEPGPLQCEAK---PLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPT 458

Query: 261 SPSPTP---SPSPVLEPGSE-PNLAVLSIPGDTMTTIQMSVE-------ESTPISRETGE 309
           SP P     SP P   P S  P    LS P +         E       ES+P S     
Sbjct: 459 SPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEES 518

Query: 310 PYRLSPEPTPLAEPILEVEVT-------LSKPVPESEFSSSPLQAPTPLASHTVEIHEPN 362
           P  LSP       P LE  ++       LS P  ES  S  P + PT        +  P 
Sbjct: 519 P--LSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPP 576

Query: 363 GMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE-- 420
              P   + P  E SP   PP A     P   +P + P E    +P P A  LSP  E  
Sbjct: 577 EESP---MSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDS 633

Query: 421 PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEE--MEEEEEEEEGEAGEAGEAESEK 478
           P     E +    PP +   +P    S  SP  EE       EE       EA       
Sbjct: 634 PMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSP-- 691

Query: 479 GGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEAN 538
                 PPE +P       +  +       +S+P     +  L ++  +    +     +
Sbjct: 692 ------PPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEG-PHLS 744

Query: 539 PAVPEVENQP-PAGSNPGPESEGSGVPPRPEE 569
           P   E    P P   +  P++E   + P+PEE
Sbjct: 745 PRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEE 776



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 132/549 (24%), Positives = 194/549 (35%), Gaps = 98/549 (17%)

Query: 10  PPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSA 69
           PPP  SP  P P   P  T+P     P+A++++ P +      P+   P +   SR    
Sbjct: 442 PPPEESPLSPPPEESP--TSP----PPEASRLSPPPEE----LPASPLPEALHLSRPLEE 491

Query: 70  APARPGP----------AAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQ 119
           +P  P P          ++   P     +  P +     +      P    S    P ++
Sbjct: 492 SPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEE 551

Query: 120 YPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIA------- 172
            P+ P  P   P + P E    A    P    ++ P    P    M+ PP+ +       
Sbjct: 552 SPLSP-PPEELPTSPPPE----ASRLSPPP--EESPMSPPPEESPMSPPPEASRLFPPFE 604

Query: 173 ------PKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQV 226
                 P  E       + ++      +  MS     S  +PP     L P      P V
Sbjct: 605 ESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSP-----LPVV 659

Query: 227 AVIVRPDDRSQGAIIADRPGLPGPEHSPSESQP--SSPSPTPSPSPVLEPGSE------P 278
           + +  P + S        P  P PE SP+   P  S  SP P  SP   P  +      P
Sbjct: 660 SRLSPPPEES--------PLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPP 711

Query: 279 NLAVLSIPGDTMTTIQMSVE-------ESTPISRETGEPYRLSPEPTPLAEPILEVEVTL 331
             +++S+P +    + +  E       E   +S    EP+ LSP P    EP L  +   
Sbjct: 712 EDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPH-LSPRP---EEPHLSPQAEE 767

Query: 332 SKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED---LEPEVESSPELAPPPACPS 388
               P+ E    P     P   H     E   + P  +   L P+ E  P L+P P  P 
Sbjct: 768 PHLSPQPE---EPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTE-EPHLSPVPEEPC 823

Query: 389 ESPVPIAPTAQPE-ELLNGAPSPPAVDLSPVSE-------PEEQAKEVTASMAPPTIPSA 440
            SP P      P+ E    +P P    LSP  E       PE+  +E     AP  +P  
Sbjct: 824 LSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLF 883

Query: 441 TPATAPSATSPAQEEEMEEEEE------EEEGEAGEAGEAESEKGGEELLPPESTPIPAN 494
            P   PS +    E  + E  E       EE     +GE        +L+PP+  P+P  
Sbjct: 884 PPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSL---SPQLMPPD--PLPPP 938

Query: 495 LSQNLEAAA 503
           LS  + AAA
Sbjct: 939 LSPIITAAA 947



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 128/512 (25%), Positives = 170/512 (33%), Gaps = 124/512 (24%)

Query: 121  PVQPGAPGFYP-GASPTEF----GTYAGAYYPAQGVQQFPTGVAPAP-----VLMNQPPQ 170
            P QPGA G  P  A+PT F     T AG    A G  + P G  P P     + +  PPQ
Sbjct: 2107 PPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQ 2166

Query: 171  IAPKRERKTIRIRDP-NQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVI 229
            +  +     +  +DP         E     A     P P  TG   +P      P +   
Sbjct: 2167 VPAQ-----VPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQP------PMLGAS 2215

Query: 230  VRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPS-PVLEPGSEPNLAVLSIPGD 288
             RP     G      PG P         QPS+P P   P  P L+     NLAV   PG 
Sbjct: 2216 SRPGAGQPGEFHTTPPGTP-------RHQPSTPDPFLKPRCPSLD-----NLAVPESPGV 2263

Query: 289  TMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEV---EVTLSKP---VPESEFSS 342
                             +  EP  LSP P   +   LEV   E+  S P    P   F  
Sbjct: 2264 G--------------GGKASEPL-LSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVD 2308

Query: 343  SP----------LQAP-------TPLASHTVEIHEPN-GMVPSED-----LEPEVESSPE 379
            SP          L+ P       TP AS  VE   P  G+ P E      L P   S P+
Sbjct: 2309 SPSSGTHLGGLELKTPDVFKAPLTPRASQ-VEPQSPGLGLRPQEPPPAQALAPSPPSHPD 2367

Query: 380  L----------APPPACPSESPVP------IAPTAQPEELLNGAPSPP---AVDLSPVSE 420
            +          A PP  P   P P      + P + P +  +  P+ P   +   SP++ 
Sbjct: 2368 IFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTP 2427

Query: 421  PEEQAKEVTASMAPPTIPSATPATAPSATSPAQE------EEMEEEEEEEEGEAGEAGEA 474
                A+    S   P   S  P + P +   +++      +    +  E   +AG     
Sbjct: 2428 RPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHT 2487

Query: 475  ESEKGGEELLPPES------TPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVG 528
                GG     P          +P+    N   +  T   V  P   R        +AVG
Sbjct: 2488 SLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMR----FTFPQAVG 2543

Query: 529  DLLDAFKEANPAVPEVENQPPAGSN----PGP 556
            +         P VP+    PP G N    PGP
Sbjct: 2544 E-----PSLKPPVPQPGLPPPHGINSHFGPGP 2570



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 121/550 (22%), Positives = 184/550 (33%), Gaps = 105/550 (19%)

Query: 4    APQSTGPPPAP-------SPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQ-----PR--- 48
            +PQ+ GP  +P       SP   +P   P    P +   P+ + ++  S+     PR   
Sbjct: 789  SPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEE 848

Query: 49   QHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIP--SQISYPASQGAYYIP 106
             H  P   +PP S         P  PG      PA  ++ + P   + S     G   + 
Sbjct: 849  SHLSPELEKPPLSPRPE---KPPEEPGQC----PAPEELPLFPPPGEPSLSPLLGEPALS 901

Query: 107  GQGRSTYVVPTQQYPVQP-GAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLM 165
              G        ++ P+ P G P   P   P +                 P  ++P  +  
Sbjct: 902  EPGEPPLSPLPEELPLSPSGEPSLSPQLMPPD---------------PLPPPLSPI-ITA 945

Query: 166  NQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQ 225
              PP ++P  E     +  P     D   E    A    TP  P       P+AN   P+
Sbjct: 946  AAPPALSPLGE-----LEYPFGAKGDSDPESPLAAPILETPISPP------PEANCTDPE 994

Query: 226  VA--VIVRPDDRS-----QGAIIADRPGLPGP--EHS--PSESQPSSPSPTPSPSPVLEP 274
                +I+ P   S        ++   P    P  +HS  P  S PS  SP   P  V  P
Sbjct: 995  PVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSP 1054

Query: 275  GSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKP 334
             S P   V+ +  D     +M  E+ +       EP   SP P+P+ +    +      P
Sbjct: 1055 LS-PIGKVVGV-SDEAELHEMETEKVSEPECPALEPSATSPLPSPMGD----LSCPAPSP 1108

Query: 335  VPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPI 394
             P  +  S   +   PL        +P        L  E++ SP L  P      +P+ +
Sbjct: 1109 APALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTPMEV 1168

Query: 395  APTA------------QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASM----APPTIP 438
             P              Q E     AP+PP +  S +        +  AS     + P + 
Sbjct: 1169 YPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLG 1228

Query: 439  SATPATAPSAT---------SPAQEE-----------EMEEEEEEEEGEAGEAGEAESEK 478
            S  P    S +         SPA++E           E ++    + G A   G+AE EK
Sbjct: 1229 SPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAISGGKAEGEK 1288

Query: 479  GGEELLPPES 488
            G     P  S
Sbjct: 1289 GRRRSSPARS 1298



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 72/336 (21%), Positives = 115/336 (34%), Gaps = 49/336 (14%)

Query: 132  GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPV-----LMNQPPQIAPKRERKTIRIRDPN 186
            G +P    T  G   P+         V P P      L  QPP   P ++++ + +    
Sbjct: 4052 GTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTA 4111

Query: 187  QGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPG 246
             GG     ++ SG+ + ++  P               P V++  +P   +Q  +   +P 
Sbjct: 4112 GGGSH--GQLGSGSSSEASSVPHLLA----------QPSVSLGDQPGSMTQNLLGPQQPM 4159

Query: 247  LPGPEHSPSESQPSSPSPTPSPSPVLEPGSE-PNLAVLSIPGDTMTTIQMSVEESTPISR 305
            L  P  + +  QP      P P PVL+ G   P + ++   G     +Q  + ++  +  
Sbjct: 4160 LERPMQNNTGPQP------PKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLR- 4212

Query: 306  ETGEPYRLSPEPTPLAEPIL-------EVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
                   LSP+     + +L          V  + P  E    +SPLQ            
Sbjct: 4213 ------HLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF 4266

Query: 359  HEP-NGMVPSEDLEPEVESSPELAPPPACPSESPV--PIAPTAQPEELLNGAPSPPAVDL 415
              P  G +      P  +  P L  PP   S  PV  P+ PT          PS P    
Sbjct: 4267 PGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTP--------PPSSPQEPK 4318

Query: 416  SPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSP 451
             P   P   ++  T +  PPT P       P+   P
Sbjct: 4319 RPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPP 4354



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 90/382 (23%), Positives = 127/382 (33%), Gaps = 77/382 (20%)

Query: 147  PAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTP 206
            P    Q+   GV P+  L   P   A  R+ +   +RD        T E+ S    A+ P
Sbjct: 4631 PPSVQQKMVNGVTPSEELGEHPKDAASARDSERA-LRD--------TSEVKSLDLLAALP 4681

Query: 207  TPPQTGGG---LEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPS 263
            TPP        +E   + ++P   V   P    +  +  + P  P       E +  + S
Sbjct: 4682 TPPHNQTEDVRMESDEDSDSPDSIV---PASSPESILGEEAPRFPHLGSGRWEQEDRALS 4738

Query: 264  PT----PSPSPVLEPGSEPNLAV-LSIPGDTMTTIQ---MSVEESTPISRETGEPYRLSP 315
            P     P  S  + P ++P  A+ L +PG    T        E S  ++        L+ 
Sbjct: 4739 PVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNG 4798

Query: 316  EPTPLAEPILEVEVTLSKPVPESE---FSSSPLQAPTPLASHTVE--------------I 358
                +AE        LS  +P S    F  SP +A T       E               
Sbjct: 4799 VMVAVAE-------LLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPD 4851

Query: 359  HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQ------------------P 400
              P+ +   + + P      +L        ESP P  PT                    P
Sbjct: 4852 TGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPP 4911

Query: 401  EELLNGAPSPPAVDL--SPVSEPEEQAKEV-TASMAPPTIPSATPATAPSATSPAQEEEM 457
            EE     PSPP   L  SP S P E   E+ T  +A P +PS  P     A+SP      
Sbjct: 4912 EE-----PSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLP----LASSPESARPK 4962

Query: 458  EEEEEEEEGEAGEAGEAESEKG 479
                  EEGE       +  KG
Sbjct: 4963 PRARPPEEGEDSRPPRLKKWKG 4984



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 161/747 (21%), Positives = 244/747 (32%), Gaps = 189/747 (25%)

Query: 5    PQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPR----QHFYPS------ 54
            P+   PPP     LP  + P    + V  S    +   +P  PR    + F PS      
Sbjct: 2385 PRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRF 2444

Query: 55   -----RAQPPSSAASRVQSA---APARPGPAAHVYPAGSQV----------MMIPS---- 92
                  ++PPS   SR   A    P RP P    + AGS              +P+    
Sbjct: 2445 QSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAG 2504

Query: 93   --QISYPASQGAYYIPGQGRSTYV---------------VPTQQYPV-QPGAP------- 127
                  P+ Q   ++   G   +V                P+ + PV QPG P       
Sbjct: 2505 ELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINS 2564

Query: 128  ---------------------GFYPGASPTEFGTYAGAYYPAQGVQQF-PTGVAPAPVLM 165
                                  F+P  SP   G  +G+   + G+    P  V P P   
Sbjct: 2565 HFGPGPTLGKPQSTNYTVATGNFHPSGSP--LGPSSGSTGESYGLSPLRPPSVLPPPAPD 2622

Query: 166  NQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGG------LEPQA 219
               P ++    +++  I  P +  +D    + S   TA  P     G        LE Q 
Sbjct: 2623 GSLPYLSHGASQRS-GITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQR 2681

Query: 220  NGETPQVAV----IVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPS------------ 263
              +  +  +    I R   R +    A   G  GP  S   ++PSSP+            
Sbjct: 2682 QRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWG-AEPSSPAFEQLSRGQTPFA 2740

Query: 264  ------------PTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPY 311
                        P+    P+L PGS P+   LS P    T   M V  S  +   +   Y
Sbjct: 2741 GTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDV-NSRQLVGGSQAFY 2799

Query: 312  RLSPEPTPL--------------AEPILEVEVTLSKPVPESEFSSSPLQA-PTPLASHTV 356
            + +P P  L              A     +   +S   P +       QA  +PLA  + 
Sbjct: 2800 QRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGIST 2859

Query: 357  EIHEPNGMV-----PSEDLEPEVESSPELAP---------PPACP-----SESPVPIAPT 397
             +  P   V     P++ +E        L P         PP  P     SE P  +AP 
Sbjct: 2860 RLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPE 2919

Query: 398  AQPEELLNGAP-----SPPAVDLSPVSEPEEQAKEVTASMAPPTI---PSAT------PA 443
                  ++G P     +PPA +L+    P    K  T       +   PS+T      P 
Sbjct: 2920 GLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNPL 2979

Query: 444  TAPSATSPAQEEEMEEE-------EEEEE----GEAGEAGEAESEKGGEELLPPESTPIP 492
               +   P ++ E++++       E++EE    G   +  + + E G  E L      + 
Sbjct: 2980 ALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLD 3039

Query: 493  ANLS-QNLEAAAATQVAVSVPKRR-------RKIKELNKKEAVGDLLDAFKEANPAVPEV 544
              L+    +  A T   +    ++       R ++  N+K     LL    E  P  PE 
Sbjct: 3040 DLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGV-EPGPLGPE- 3097

Query: 545  ENQPPA--GSNPGPESEGSGVPPRPEE 569
            E  PPA   S P   S    V P+ EE
Sbjct: 3098 ERPPPAADASEPRLASVLPEVKPKVEE 3124



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 91/396 (22%), Positives = 128/396 (32%), Gaps = 48/396 (12%)

Query: 198  SGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPD-DRSQGAIIADRPGLPGPEHSPSE 256
            SG  T STPT P T G    + +G +     + R + D   G +    P L    + P+ 
Sbjct: 1976 SGGTTPSTPTTPTTEG----EGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNL 2031

Query: 257  SQ--PSSPS------------PTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEEST- 301
             Q  P   S            P    +P L+   +   A            Q++ +    
Sbjct: 2032 KQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVG 2091

Query: 302  PISRETGEP---YRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
             I+R+T  P    R+ P+P  L  P      T+        F  SP        S    +
Sbjct: 2092 DIARKTDRPALHLRIPPQPGALGSPPPAAAPTI--------FIGSPTTPAGLSTSADGFL 2143

Query: 359  HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
              P G VP  D   E+        P   PS+ P  +AP    E     AP       SP 
Sbjct: 2144 KPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPT 2203

Query: 419  SEPEEQAKEVTASMAP--------PTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGE 470
              P  Q   + AS  P         T P  TP   PS   P  +      +     E+  
Sbjct: 2204 GAP-AQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPG 2262

Query: 471  AGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDL 530
             G     K  E LL    +P P   S+        ++  S P             + G  
Sbjct: 2263 VG---GGKASEPLL----SPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTH 2315

Query: 531  LDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPR 566
            L   +   P V +    P A S   P+S G G+ P+
Sbjct: 2316 LGGLELKTPDVFKAPLTPRA-SQVEPQSPGLGLRPQ 2350



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 92/473 (19%), Positives = 158/473 (33%), Gaps = 58/473 (12%)

Query: 9    GPPPAPSPGLPQP--AFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRV 66
            GP P   P LP P  A   G     V  TP  +    P +P Q   PS    PSS     
Sbjct: 4280 GPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQ--LPS----PSSQLPTE 4333

Query: 67   QSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQ-PG 125
                P  PG      P G  +   P ++S  A+Q A  +  +G   +  P      Q P 
Sbjct: 4334 AQLPPTHPGTPK---PQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPE 4390

Query: 126  APGFYPGASPTEFGTY---AGAYYPAQGVQQFPTGVAPAPVL--MNQPPQIAPKRERKTI 180
                 PG      G     A      Q  ++ P  +    V    N  P  AP      +
Sbjct: 4391 QSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLL 4450

Query: 181  RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI 240
                 ++ G  + ++++  A+     T  +   GL  + NG            D     +
Sbjct: 4451 LAGPRSEAGHLLLQKLLR-AKNVQLST-GRGSEGLRAEINGHI----------DSKLAGL 4498

Query: 241  IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES 300
                 G P  +   +  +P +P P                  +    D + + +  + + 
Sbjct: 4499 EQKLQGTPSNKEDAAARKPLTPKPKR----------------VQKASDRLVSSRKKLRKE 4542

Query: 301  TPISRETGEPYRLSPEPT--PLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI 358
              +        +L  E +  PL EP +    +L  P      S  P+   + L       
Sbjct: 4543 DGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFG----SGCPVNGQSQLRGAFGSG 4598

Query: 359  HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
              P G     D   ++ +   L+ PP  PS  P P  P +  ++++NG    P+ +L   
Sbjct: 4599 ALPTG----PDYYSQLLTKNNLSNPPTPPSSLP-PTPPPSVQQKMVNGV--TPSEELGEH 4651

Query: 419  SEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEA 471
             +    A++   ++   +   +    A   T P  + E    E +E+ ++ ++
Sbjct: 4652 PKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDS 4704



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 46/215 (21%), Positives = 71/215 (33%), Gaps = 57/215 (26%)

Query: 246  GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISR 305
            G PGP+  P +   + P P   P     PG+     VL                      
Sbjct: 4265 GFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLG--------------------- 4303

Query: 306  ETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMV 365
                P   +P P+   EP                    P Q P+P +    E   P    
Sbjct: 4304 ----PVHPTPPPSSPQEP------------------KRPSQLPSPSSQLPTEAQLP---- 4337

Query: 366  PSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQA 425
            P+    P+ +  P L PPP   S +   +A T   + L    P  P  +L+   +PE+  
Sbjct: 4338 PTHPGTPKPQ-GPTLEPPPGRVSPAAAQLADTLFSKGL---GPWDPPDNLAETQKPEQ-- 4391

Query: 426  KEVTASMAPPTIPSATPATAPSATSPAQEEEMEEE 460
                +S+ P  +        P A+  + ++E  EE
Sbjct: 4392 ----SSLVPGHLDQVNGQVVPEASQLSIKQEPREE 4422



 Score = 32.0 bits (71), Expect = 4.9
 Identities = 27/76 (35%), Positives = 31/76 (40%), Gaps = 19/76 (25%)

Query: 4    APQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPP-SSA 62
            AP    P P PSP  P PA PP  T P+V           P++P        A+PP  S 
Sbjct: 4908 APPPEEPSPPPSPLAPSPASPP--TEPLV---------ELPTEP-------LAEPPVPSP 4949

Query: 63   ASRVQSAAPARPGPAA 78
                 S   ARP P A
Sbjct: 4950 LPLASSPESARPKPRA 4965


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 129/513 (25%), Positives = 168/513 (32%), Gaps = 78/513 (15%)

Query: 5    PQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAAS 64
            P    PP APSP    P  PPG   P V S P A  M           PS    PS  A 
Sbjct: 648  PAPVPPPEAPSPFRAPPFHPPGPM-PSVGSMPSAGPM-----------PSAGPMPS--AG 693

Query: 65   RVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQP 124
             V SA P  P  A H+       + +P  +S P                        + P
Sbjct: 694  PVPSARPGPPTTANHLG------LSVPGLVSVPPR----------------------LLP 725

Query: 125  GAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRD 184
            G      G++       +G   P     +   G  P P  ++   + A   E   I +  
Sbjct: 726  GPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVE---ISLES 782

Query: 185  PNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADR 244
             +     I  E +        P PP +G    P A    P  +  V   +  +     + 
Sbjct: 783  DSDDSVVIVPEGLP-----PLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPE-----EL 832

Query: 245  PGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSV---EEST 301
            P  PGP   P    P  P P   P P L P   P         + +T I ++    EE  
Sbjct: 833  PAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEE 892

Query: 302  PISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEI--H 359
                E  E      E     E   E E    +   E EF     +    L     E    
Sbjct: 893  EEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEE 952

Query: 360  EPNGMVPSEDLE-----PEVESSPELAPPPACPSESPVPIAPT-AQPEELLNGAPSPPAV 413
            E   +   EDLE      EVE      PPP  P   P P +P   QPE      P P   
Sbjct: 953  EEEELEEVEDLEFGTAGGEVEEGAP--PPPTLPPALPPPESPPKVQPE------PEPEPG 1004

Query: 414  DLSPVSEP---EEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGE 470
             L  V EP   EE+  +   ++AP  +PS          SPA     +E  EEE      
Sbjct: 1005 LLLEVEEPGTEEERGADTAPTLAPEALPSQGEVER-EGESPAAGPPPQELVEEEPSAPPT 1063

Query: 471  AGEAESEKGGEELLPPESTPIPANLSQNLEAAA 503
              E E+E G +++ PP  TP    +    EA A
Sbjct: 1064 LLEEETEDGSDKVQPPPETPAEEEMETETEAEA 1096



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 92/360 (25%), Positives = 129/360 (35%), Gaps = 29/360 (8%)

Query: 250  PEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 309
            P   P  S    PS  P PS    P +  N   LS+PG      ++        +    +
Sbjct: 678  PSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNED 737

Query: 310  PYRLSPEPTPLAEPILEVEVTLSKPVPESEF------SSSPLQAPTPLASHTVEIHEPNG 363
            P  L+P  TP   P +  + T    VP   F       +S ++      S    +  P G
Sbjct: 738  PI-LAPSGTP--PPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEG 794

Query: 364  MVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEL------LNGAPSPPAVDLSP 417
            + P     P   + P +AP    P+ SP P+    +PEEL      L   P PP     P
Sbjct: 795  LPPLPPPPPSGATPPPIAPTGP-PTASP-PVPAKEEPEELPAAPGPLPPPPPPPPPVPGP 852

Query: 418  VSEPEEQA--KEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAE 475
            V+ P  Q   +       PP +         +++   +EEE EEEEEEEE E  E    E
Sbjct: 853  VTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEE 912

Query: 476  SEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFK 535
             E+  EE    E         +  E            +   + +EL + E + +   A  
Sbjct: 913  EEEDEEEYFEEEEEE-EEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDL-EFGTAGG 970

Query: 536  EANPAVPEVENQPPAGSNPGPESEGSGVP-PRPE-----EADETWDSKEDKIHNAENIQP 589
            E     P     PPA   P PES     P P PE     E +E    +E     A  + P
Sbjct: 971  EVEEGAPPPPTLPPA--LPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAP 1028



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 75/321 (23%), Positives = 116/321 (36%), Gaps = 41/321 (12%)

Query: 319 PLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSP 378
           P   P+  +  T   P P       P +AP+P  +     H P  M       P V S P
Sbjct: 633 PRVPPLQPMGPTCPTPAPVP-----PPEAPSPFRAPP--FHPPGPM-------PSVGSMP 678

Query: 379 ELAPPPAC---PSESPVPIAPTAQPEELLN-GAPSPPAVDLSPVSEPEEQAKEVTASMAP 434
              P P+    PS  PVP A    P    + G   P  V + P   P  +     ++  P
Sbjct: 679 SAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDP 738

Query: 435 PTIPSATPATA--PSATSPAQ--EEEMEEEEEEEEGEAGEAGEAESEKGG---EELLPPE 487
              PS TP     P  T   +         ++EE  +   + E++S+       E LPP 
Sbjct: 739 ILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPL 798

Query: 488 STPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQ 547
             P P+  +    A      A      + + +EL    A    L       P VP     
Sbjct: 799 PPPPPSGATPPPIAPTGPPTASPPVPAKEEPEEL---PAAPGPLPPPPPPPPPVPGPVTL 855

Query: 548 PPAGSNPGPESEGSGVPPRPEE---------ADETWDSKEDKIHNAENIQPGEQKYEYK- 597
           PP    P   + G G PP  EE         +DE  + +E++    E  +  E+ +E + 
Sbjct: 856 PPPQLVP-EGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEE 914

Query: 598 --SDQWKPLNLEEKKRYDREF 616
              +++     EE++ ++ EF
Sbjct: 915 EDEEEYFEEEEEEEEEFEEEF 935



 Score = 31.6 bits (70), Expect = 6.4
 Identities = 15/42 (35%), Positives = 29/42 (69%), Gaps = 3/42 (7%)

Query: 848 QKEFEKDKDDDEVF---EKKQKEMDEAATAEERGRLKEELEE 886
           +++FE++++D+E +   E++++E  E    EE G L+EE EE
Sbjct: 907 EEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEE 948


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 130/537 (24%), Positives = 190/537 (35%), Gaps = 85/537 (15%)

Query: 10   PPPAPSPGLPQPA-FPPGQTAPVVFSTPQATQMN---------TPSQPRQHFYPSRAQPP 59
            P PAP+PG    A   P  T  + F+ P  T  N         TP  P     PS   P 
Sbjct: 840  PAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPK 899

Query: 60   SSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRST---YVVP 116
            + + S VQ+  P            G    ++P ++  P +  +  + G G       V P
Sbjct: 900  AQSVSPVQAPPP------------GGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSP 947

Query: 117  TQQYPVQPGA--PGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPK 174
                PVQ GA  P      +P    T +G   P            P P   +QP ++   
Sbjct: 948  PFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLS------PATLPGPT--SQPQKVLLP 999

Query: 175  RERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPD- 233
               +   ++  + GG  +       +  A T T       +        P     V+P  
Sbjct: 1000 SSTRITYVQ--SAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLL 1057

Query: 234  DRSQGAIIADRPG------LPGPEHSPSESQPSSP--------SPTPSPS-PVLEPGSEP 278
               Q  ++A  PG      +P P+  P+ + P  P        SP P+ S P+ +P   P
Sbjct: 1058 SAGQAPLLA--PGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAP 1115

Query: 279  NLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPES 338
               V ++   T T    ++    P +  T  P   SP P+  A       +T S   P++
Sbjct: 1116 PSLVYTVATST-TPPAATILPKGPPAPATATPAPTSPFPSATAG-----SMTYSLVAPKA 1169

Query: 339  EFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTA 398
                   Q P+P A   V+    +  +P    E      P   P P  P E P P+    
Sbjct: 1170 -------QRPSPKAPQKVKAAIAS--IPVGSFEAGASGRP--GPAPRQPLE-PGPVREPT 1217

Query: 399  QPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 458
             PE  L G P+PPA    P   PE      TA  +PP  P A   T  SA  P   E M 
Sbjct: 1218 APESELEGQPTPPA----PPPLPETWTP--TARSSPPLPPPAEERT--SAKGP---ETMA 1266

Query: 459  EEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRR 515
             +      +    G+   E  GE   PP   P PA        +++ + A   P+R+
Sbjct: 1267 SKFPSSSSDWRVPGQG-LENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERK 1322



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 113/428 (26%), Positives = 156/428 (36%), Gaps = 57/428 (13%)

Query: 3   KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
           K P+S G    P P +   A PP     ++      T +  P++  Q      A+ PS+ 
Sbjct: 601 KRPESVGGLEPPGPSVI--AAPPSGGGNIL-----QTLVLPPNKEEQE--GGGARVPSAP 651

Query: 63  ASRVQSAAPARP--GPAAH-----VYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVV 115
           A  +   APA P   PAA      V P  S  + I S+  +P S  A   P         
Sbjct: 652 APSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASK-PFPTSGRAEASPND------- 703

Query: 116 PTQQYPVQPGAPGFYPGASPTEFGTY------AGAYYPAQGVQQFP----TGVAPAPV-- 163
            T     + G     PG SP            A A  PA  +   P     G APA V  
Sbjct: 704 -TAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTN 762

Query: 164 -LMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGE 222
            L+  P   AP         +    GG        SGA   S P  P   G L+P A G+
Sbjct: 763 LLVGTPGYGAPAPPAVQFIAQGAPGGGTTAG----SGAGAGSGPNGPVPLGILQPGALGK 818

Query: 223 TPQVAVI--VRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNL 280
              +  +  + P    Q  +       P P      + PS P+PT S    L PG+  N 
Sbjct: 819 AGGITQVQYILPTLPQQLQVAP----APAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNG 874

Query: 281 AVLSIPGDTM-TTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESE 339
            VL+    T    I  SV  + P   ++  P + +P P   A+ +L  +V +    P   
Sbjct: 875 KVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQ-APPPGGSAQ-LLPGKVLVPLAAPSMS 932

Query: 340 FSSSPLQAPTPLASHTVEIHEPNGMVPSE---DLEPEVESSPELAPPPACPSESPVPIAP 396
                   P PL S    +   NG  P      L P   S+P    PP  P+  P    P
Sbjct: 933 VRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLP---GP 989

Query: 397 TAQPEELL 404
           T+QP+++L
Sbjct: 990 TSQPQKVL 997



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 74/292 (25%), Positives = 102/292 (34%), Gaps = 45/292 (15%)

Query: 4    APQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAA 63
            AP   G  P PSP LP     PG   PV+ +    +   T S P        AQP  +  
Sbjct: 1066 APGQVGVSPVPSPQLPPACAAPG--GPVITAFYSGSPAPTSSAP-------LAQPSQAPP 1116

Query: 64   SRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTY--VVPTQQYP 121
            S V + A +   PAA + P G          + PA    +     G  TY  V P  Q P
Sbjct: 1117 SLVYTVATSTTPPAATILPKGPPA----PATATPAPTSPFPSATAGSMTYSLVAPKAQRP 1172

Query: 122  VQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTG-VAPAPVLMNQPPQIAPKRERKTI 180
              P AP     A          A  P    +   +G   PAP    QP +  P RE    
Sbjct: 1173 -SPKAPQKVKAAI---------ASIPVGSFEAGASGRPGPAP---RQPLEPGPVREPTAP 1219

Query: 181  RIR---DPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQ 237
                   P         E  +    +S P PP      E + + + P+      P   S 
Sbjct: 1220 ESELEGQPTPPAPPPLPETWTPTARSSPPLPPPA----EERTSAKGPETMASKFPSSSSD 1275

Query: 238  GAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDT 289
              +    PG    +   +  +P +P P+P+P+P + PG     +     GDT
Sbjct: 1276 WRV----PG----QGLENRGEPPTP-PSPAPAPAVAPGGSSESSSGRAAGDT 1318



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 42/178 (23%), Positives = 59/178 (33%), Gaps = 33/178 (18%)

Query: 310 PYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 369
           P+    +P P  +P  E +   S PV  +       Q+  P  S  V    P G   S D
Sbjct: 42  PFLAPSQPDPSVQPS-EAQQPASHPVASN-------QSKEPAESAAVAHERPPGGTGSAD 93

Query: 370 LEPEVESSPELAPPPACPSESPVP------------IAPTAQPEELLNGAPSPPAVDLSP 417
            E          PP A   ESP P              P    EE  +G P  P +D   
Sbjct: 94  PE---------RPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLD--- 141

Query: 418 VSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAE 475
            SE E    +   S+  P I    P       S +   +  +   E++G +    E +
Sbjct: 142 -SETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKD 198


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 132/568 (23%), Positives = 202/568 (35%), Gaps = 102/568 (17%)

Query: 12  PAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAP 71
           P+   GL +PA     ++    S+P  +  +    PR   +PS+ +P    A R     P
Sbjct: 219 PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 278

Query: 72  ARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYP 131
            R   A  + P  S  +  PS  + P+       P    S   +P+   P  P +     
Sbjct: 279 PRKDAAPALGPLSSSPLATPSPSAPPS-------PSAPPSLQTLPSP--PATPPSQATTS 329

Query: 132 GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKD 191
             SPT   T+  ++ P+  +    T    AP  +  PP  AP                  
Sbjct: 330 LGSPTLQATH--SFLPSPPLSPLATPPPQAPPALALPPLQAP------------------ 369

Query: 192 ITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLP-GP 250
                         P+PP             +P ++ +  P  ++  A+       P  P
Sbjct: 370 --------------PSPP------------ASPPLSPLATPSPQAPNALAVHLLQAPFSP 403

Query: 251 EHSPSESQPSSPSPTPSPSPVLEPGSE--PNLAV--LSIPGDTMTTIQMSVEESTPISRE 306
             SP    P SP  +P  SP   P S+  P+LA   L +P     +  MS   + P    
Sbjct: 404 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP---- 459

Query: 307 TGEPYRLSPEPTPLAEPILEVEVTLSKPVPES--EFSSSPLQA-PTPLASHTVEI-HEPN 362
                     P PLA P L+    L+KP P++    ++ PLQA P+P AS   +    P+
Sbjct: 460 -------PQAPPPLAAPPLQ----LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508

Query: 363 GMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPE 422
             +P   L     + P  APP        VP +P A P       P  P  D S VS P 
Sbjct: 509 ASLPMSPL----ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS-VSGP- 562

Query: 423 EQAKEVTASMA--PPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG 480
                +T ++A  PP  PS +P++  S    A          EE       G     +GG
Sbjct: 563 ----RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE-----LRGYDSGPEGG 613

Query: 481 EELLPPESTPI----PANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAF-- 534
               PP    +    PA  S+      A + A   P            + +  + +    
Sbjct: 614 AAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP 673

Query: 535 KEANPAVPEVENQPPAGSNPGPESEGSG 562
           + A PA   ++  P  G++ G  + G+G
Sbjct: 674 ESATPAPGALDPGPSPGTSGGKAAAGAG 701



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 125/532 (23%), Positives = 169/532 (31%), Gaps = 97/532 (18%)

Query: 4   APQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQ----------------- 46
           A  + GP  +     P P+ PP  +AP    T  +     PSQ                 
Sbjct: 283 AAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 342

Query: 47  PRQHFYPSRAQPPSSAASRVQSAAPARPGPAAH--VYPAGSQVMMIPSQISYPASQGAYY 104
           P     P    PP +  +       A P P A   + P  +     P+ ++    Q  + 
Sbjct: 343 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 402

Query: 105 IPGQGRSTYVVPTQQYPVQPGA-PGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPV 163
            P         P  Q P  P A P   P A+P      + A  P Q V   P    P   
Sbjct: 403 PPPS-------PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ-VPPSPPASPPMSP 454

Query: 164 LMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGET 223
               PPQ  P      +++  P                      PPQ    L       T
Sbjct: 455 SATPPPQAPPPLAAPPLQLAKP----------------------PPQAPPAL------AT 486

Query: 224 PQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVL 283
           P +  +  P         A  PG      SPS S P SP  TP P             VL
Sbjct: 487 PPLQALPSPP--------ASFPG--QAPFSPSASLPMSPLATPPPQAP---------PVL 527

Query: 284 SIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTP---LAEPILEVEVTLSKPVPESEF 340
           + P        + V  S P S     P R  P P P   ++ P L + +    P P S  
Sbjct: 528 AAP-------LLQVPPSPPASPTLQAP-RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 579

Query: 341 SSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQP 400
            SS L  P  LA H+         +   D  P  E     +PPP     +  P A +  P
Sbjct: 580 PSSTLSGP-DLAGHSSSATSTPEELRGYDSGP--EGGAAASPPPDAELAACHPAAWSRGP 636

Query: 401 EELL--NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEME 458
              L   GAP  P +   P + P   A  +          SATP  AP A  P       
Sbjct: 637 APPLAFRGAPGAP-LPWPPATGP-GSADGLCTIYETEGPESATP--APGALDPGPSPGTS 692

Query: 459 EEEEEEEGEAGEAGEA--ESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 508
             +      AG +  +  ++  G   L   +++ +   LS+ L  AAA   A
Sbjct: 693 GGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAA 744


>gi|33386693 poly(A) binding protein interacting protein 1 isoform 2
           [Homo sapiens]
          Length = 400

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 73/310 (23%), Positives = 141/310 (45%), Gaps = 57/310 (18%)

Query: 701 PRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDL 760
           P+++ +    +P+ ++A VLM++ + +N  E      S       + G ED        L
Sbjct: 26  PQQNSESAMAKPQVVVAPVLMSK-LSVNAPEFYPSGYSSSYTESYEDGCEDYP-----TL 79

Query: 761 FRRVRSILNKLT--PQMFQQLMKQVTQL---AIDTEERLKGVIDLIFEKAISEPNFSVAY 815
              V+  LN LT  P  F+  ++Q  +     + T++ L+ +++LI+++A S PNFS   
Sbjct: 80  SEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMG 139

Query: 816 ANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAE 875
           A +C  L      + +      NFR+LLL RC+ E+E                       
Sbjct: 140 ARLCNYLSHHLTISPQSG----NFRQLLLQRCRTEYE----------------------- 172

Query: 876 ERGRLKEELEEARDIARRRSLGNIKFIGELF-KLKM-----------LTEAIMHDCVVKL 923
               +K++  +  ++ R+R    + F+GEL+  L++           + +  + + +  L
Sbjct: 173 ----VKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNAL 228

Query: 924 LKNHDEESLECLCRLLTTIGKDLDF---EKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQ 980
             N  +++L C  +LL   G  L+    EK K  M++   ++E ++ +   S  ++ ML 
Sbjct: 229 FSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLL 288

Query: 981 DVLDLRGSNW 990
            +++LR SNW
Sbjct: 289 KLVELRSSNW 298


>gi|17511255 poly(A) binding protein interacting protein 1 isoform 1
           [Homo sapiens]
          Length = 479

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 73/310 (23%), Positives = 141/310 (45%), Gaps = 57/310 (18%)

Query: 701 PRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDL 760
           P+++ +    +P+ ++A VLM++ + +N  E      S       + G ED        L
Sbjct: 105 PQQNSESAMAKPQVVVAPVLMSK-LSVNAPEFYPSGYSSSYTESYEDGCEDYP-----TL 158

Query: 761 FRRVRSILNKLT--PQMFQQLMKQVTQL---AIDTEERLKGVIDLIFEKAISEPNFSVAY 815
              V+  LN LT  P  F+  ++Q  +     + T++ L+ +++LI+++A S PNFS   
Sbjct: 159 SEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMG 218

Query: 816 ANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAE 875
           A +C  L      + +      NFR+LLL RC+ E+E                       
Sbjct: 219 ARLCNYLSHHLTISPQSG----NFRQLLLQRCRTEYE----------------------- 251

Query: 876 ERGRLKEELEEARDIARRRSLGNIKFIGELF-KLKM-----------LTEAIMHDCVVKL 923
               +K++  +  ++ R+R    + F+GEL+  L++           + +  + + +  L
Sbjct: 252 ----VKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNAL 307

Query: 924 LKNHDEESLECLCRLLTTIGKDLDF---EKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQ 980
             N  +++L C  +LL   G  L+    EK K  M++   ++E ++ +   S  ++ ML 
Sbjct: 308 FSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLL 367

Query: 981 DVLDLRGSNW 990
            +++LR SNW
Sbjct: 368 KLVELRSSNW 377



 Score = 31.6 bits (70), Expect = 6.4
 Identities = 31/123 (25%), Positives = 42/123 (34%), Gaps = 20/123 (16%)

Query: 361 PNGMVPSED-------------LEPEVESSPELAPPPACPSESPV----PIAPTAQPEEL 403
           PNG  P+E              L+P     P   PPP    E P     P  P A PE+ 
Sbjct: 32  PNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQT 91

Query: 404 LNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSAT---PATAPSATSPAQEEEMEEE 460
                 P + D  P    E    +    +AP  +   +   P   PS  S +  E  E+ 
Sbjct: 92  RPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDG 151

Query: 461 EEE 463
            E+
Sbjct: 152 CED 154


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 149/666 (22%), Positives = 225/666 (33%), Gaps = 149/666 (22%)

Query: 41   MNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQ 100
            +  P +P +   P   +PP++  S    AAP  P PA    P                S 
Sbjct: 519  LGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPG--------------LSP 564

Query: 101  GAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAP 160
            G    P +     + P+  Y  Q G P                           P G+A 
Sbjct: 565  GGSRRPPRSPERTLSPSSGYSSQSGTPTLP------------------------PKGLAG 600

Query: 161  APVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQAN 220
             P     P +  P +  +   +R P   G  ++  + S   ++S P P    G   PQ  
Sbjct: 601  PPA---SPGKAQPPKPERVTSLRSP---GASVSSSLTSLCSSSSDPAPSDRSG---PQ-- 649

Query: 221  GETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPT----PSPSPVLEPGS 276
                   ++    DR    +I   P +P P  SP  S+P SP+P      +P+ V  P S
Sbjct: 650  -------ILTPLGDR---FVIPPHPKVPAP-FSPPPSKPRSPNPAAPALAAPAVVPGPVS 698

Query: 277  EPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVP 336
              + +  S P  T  T    ++ES  IS++   P    P P P   P          P P
Sbjct: 699  TTDASPQSPP--TPQTTLTPLQESPVISKDQSPP----PSPPPSYHP----------PPP 742

Query: 337  ESEFSSSPLQAPTPLASHTVE--IHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPI 394
             ++     ++AP+  AS T E  + +PN                   PPP  P E  + +
Sbjct: 743  PTKKPEVVVEAPS--ASETAEEPLQDPNWP----------------PPPPPAPEEQDLSM 784

Query: 395  APTAQPEELLNGAPSP----PAVDLSPVSEPEEQAKEVTASM----APPTIPSATPATAP 446
            A    PEE      SP    P+     VS P   +   TA        P  P A PA AP
Sbjct: 785  ADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844

Query: 447  SATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQ 506
            ++++P    ++ ++E        + G    E  G  L+ P    +    S      A T 
Sbjct: 845  ASSAPGHVAKLPQKEPV---GCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTP 901

Query: 507  V----AVSVPKRRRKIKELNKKEAVGDLLDAFKEANP-AVPEVENQPPAGSNPGPESEGS 561
                 A   P RR      +   A    L A       ++   E    A  N  PE+E  
Sbjct: 902  ALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAE-- 959

Query: 562  GVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQ 621
               PRP ++  +  S             G +K + +    +P++ E +    R  +   +
Sbjct: 960  ---PRPPQSPASTAS--------FIFSKGSRKLQLE----RPVSPETQADLQRNLVAELR 1004

Query: 622  FIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTR 681
             I  S Q+P   P           K+P  P    R   +   P  +PS+      T    
Sbjct: 1005 SI--SEQRPPQAP----------KKSPKAPPPVARKPSVGVPPPASPSYPRAEPLT---- 1048

Query: 682  GPPRGG 687
             PP  G
Sbjct: 1049 APPTNG 1054



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 115/484 (23%), Positives = 162/484 (33%), Gaps = 98/484 (20%)

Query: 3    KAPQSTGPPPA----PSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQP 58
            K P    PPP+    P+P  P  A P     PV  ST  A+  + P+ P+    P +  P
Sbjct: 665  KVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPV--STTDASPQSPPT-PQTTLTPLQESP 721

Query: 59   PSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQ 118
                 S+ QS  P+ P P+ H  P              P  +    +     S       
Sbjct: 722  ---VISKDQSPPPS-PPPSYHPPPP-------------PTKKPEVVVEAPSASETAEEPL 764

Query: 119  QYPVQPGAPGFYP---GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKR 175
            Q P  P  P   P     S  +F     A++     +  P G + +P L++ P   A   
Sbjct: 765  QDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPE--PAGPSGSPELVSSP--AASSS 820

Query: 176  ERKTIRIRDPNQGGKDITEEIMSGARTA---------STPTPPQTGGGLEPQANGE---T 223
                ++I+ P            + A +A           P     GGG   +  G    T
Sbjct: 821  SATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT 880

Query: 224  PQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQ-PSSPSPTPSPSPVLEPGSEPNLAV 282
            P +  +VR   RS GA      G P P   PS  Q P   + +   SPV  P S  + AV
Sbjct: 881  PSLLQMVRL--RSVGA----PGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAV 934

Query: 283  LSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSS 342
                   +    ++  E    ++  G P     EP P   P        SK        S
Sbjct: 935  ------RLKACSLAASEGLSSAQPNGPP---EAEPRPPQSPASTASFIFSK-------GS 978

Query: 343  SPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
              LQ   P++  T    + N       L  E+ S  E  PP A P +SP    P A+   
Sbjct: 979  RKLQLERPVSPETQADLQRN-------LVAELRSISEQRPPQA-PKKSPKAPPPVARKPS 1030

Query: 403  LLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEE 462
            +  G P P                      A P+ P A P TAP        ++  + E 
Sbjct: 1031 V--GVPPP----------------------ASPSYPRAEPLTAPPTNGLPHTQDRTKREL 1066

Query: 463  EEEG 466
             E G
Sbjct: 1067 AENG 1070



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 57/256 (22%), Positives = 87/256 (33%), Gaps = 29/256 (11%)

Query: 254 PSESQPSSPSPTPSPSP----VLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 309
           P    PSS S T S S     ++  GS      LS  G +    + S   ++ +    G 
Sbjct: 404 PRSRHPSSSSDTWSHSQSSDTIVSDGS-----TLSSKGGSEGQPESSTASNSVVPPPQGG 458

Query: 310 PYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSED 369
             R SP     AE    + +  S  +     S   L+ P P    T  +H+    VP   
Sbjct: 459 SGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGP 518

Query: 370 L----EPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPS-PPAVDLSPVSEPE-- 422
           L    +PE +  P+L  PP          AP   P    +  P   P     P   PE  
Sbjct: 519 LGLPPKPERKQQPQLPRPPTTGGSEGAGAAP-CPPNPANSWVPGLSPGGSRRPPRSPERT 577

Query: 423 -EQAKEVTASMAPPTIPS---ATPATAPSATSPAQEEEMEEEEEEEEGE--------AGE 470
              +   ++    PT+P    A P  +P    P + E +                  +  
Sbjct: 578 LSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSS 637

Query: 471 AGEAESEKGGEELLPP 486
           +  A S++ G ++L P
Sbjct: 638 SDPAPSDRSGPQILTP 653


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 115/506 (22%), Positives = 165/506 (32%), Gaps = 109/506 (21%)

Query: 12   PAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAP 71
            P P P  P+P  P  + +       +A +   P +  +   P     P    + + SA P
Sbjct: 716  PPPRPTAPKPLLPRREES-------EAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATP 768

Query: 72   ARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYP 131
                P+    P  S     P  +S P   G          TY  PTQ   +QP APG  P
Sbjct: 769  LHFPPS----PFPSSTGPGPHYLSGPLPPG----------TYSGPTQL--IQPRAPG--P 810

Query: 132  GASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKD 191
             A P                      VAP P L   P   A   E   +    P  G   
Sbjct: 811  HAMP----------------------VAPGPALYPAP---AYTPELGLVPRSSPQHG--- 842

Query: 192  ITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPE 251
                ++S       P PP  G    P      P++A+ VRP   +  +I A  P    P 
Sbjct: 843  ----VVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPR 898

Query: 252  HSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPY 311
             +P+ + P    P P P P+  P + P  A   IP     +  +      P         
Sbjct: 899  PNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAP--------- 949

Query: 312  RLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLE 371
            R+ P+P P  +           P P   F   P Q P PL    +   +  G++P +   
Sbjct: 950  RIGPQPQPHPQ-----------PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPY 998

Query: 372  PEVESSPELAPPP--------ACPSESPVPI----------APTAQPEELLNGAPSPPAV 413
            P       L  PP          P++ P+P            P   P   L   P+P   
Sbjct: 999  PYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTR 1058

Query: 414  DLSPVSEPEEQAKEVTASMAPPT---IPSATPATAPSATSPAQEEEMEEEEEEEEGEA-- 468
             + P + P       +A  + P+   +PS  P+  P    P +    E       G A  
Sbjct: 1059 PMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPV-PPRPPAAEPPPCLRRGAAAA 1117

Query: 469  --------GEAGEAESEKGGEELLPP 486
                     + G  +S  GG+ LL P
Sbjct: 1118 DLLSSSPESQHGGTQSPGGGQPLLQP 1143



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 78/286 (27%), Positives = 102/286 (35%), Gaps = 50/286 (17%)

Query: 5    PQSTGPPPAPSPGLPQPAF--PPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSA 62
            P  T P P P+P  P P F  PP Q  P  ++ P   +   P+Q   HF  S   P    
Sbjct: 892  PSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQ--HHF--SSGIPAGFP 947

Query: 63   ASRVQSAAPARPGPAAHVYPAGSQVM-MIPSQISYPASQGAYYIPGQGRSTYVVPTQQYP 121
            A R+       P P  H  P  SQ     P Q   P  Q  +  P Q     + P   YP
Sbjct: 948  APRI------GPQPQPHPQPHPSQAFGPQPPQQPLPL-QHPHLFPPQAPG-LLPPQSPYP 999

Query: 122  V--QPGAPG---------FYPGASPTEFGTYAGAY-YPAQGVQQ---FPTGVAPAPVLMN 166
               QPG  G          YPG +      ++GA  +P+ G  Q    P    PAP    
Sbjct: 1000 YAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRP 1059

Query: 167  QPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQV 226
              PQ AP      + IR P+  G+              +P P    G + P+     P  
Sbjct: 1060 MGPQAAP------LTIRGPSSAGQS-----TPSPHLVPSPAPSPGPGPVPPRPPAAEP-- 1106

Query: 227  AVIVRPDDRSQGAIIAD-RPGLPGPEHSPSESQPSSPSPTPSPSPV 271
                 P    +GA  AD     P  +H  ++S P    P   P+ V
Sbjct: 1107 -----PPCLRRGAAAADLLSSSPESQHGGTQS-PGGGQPLLQPTKV 1146



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 78/284 (27%), Positives = 102/284 (35%), Gaps = 47/284 (16%)

Query: 10   PPPAPSPGLPQPAFPPGQTAPVV---FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRV 66
            PP A  P  P P F   + A  V    +T  + Q   PS       P+ A PP       
Sbjct: 855  PPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFP--- 911

Query: 67   QSAAPARPGPAAHVYPAGSQVMMIPSQISY----PASQGAYYI-PGQGRSTYVVPTQQYP 121
                P +P P  + YPAG++   IP+Q  +    PA   A  I P         P+Q + 
Sbjct: 912  --VPPPQPLPTPYTYPAGAK-QPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFG 968

Query: 122  VQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPP-----QIAPKRE 176
             QP      P   P  F   A    P Q     P   AP P ++ QPP     Q+ P   
Sbjct: 969  PQPPQQPL-PLQHPHLFPPQAPGLLPPQS----PYPYAPQPGVLGQPPPPLHTQLYPGPA 1023

Query: 177  RKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRS 236
            +  +                 SGA    +P PPQ      P A G  P      RP    
Sbjct: 1024 QDPLPAH--------------SGALPFPSPGPPQPPH--PPLAYGPAPS----TRPMGPQ 1063

Query: 237  QGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPV--LEPGSEP 278
               +    P   G + +PS     SP+P+P P PV    P +EP
Sbjct: 1064 AAPLTIRGPSSAG-QSTPSPHLVPSPAPSPGPGPVPPRPPAAEP 1106



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 3    KAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSS 61
            ++P ++ P PA  PGLP  + P  ++ P+  S+P       P  P+    P   + PSS
Sbjct: 1514 ESPVASLPGPAEPPGLPPASLP--ESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSS 1570



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 31/127 (24%), Positives = 50/127 (39%), Gaps = 15/127 (11%)

Query: 319  PLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSP 378
            P  +P+    ++    +P+       L    P++S    I + + + P   LE  V S P
Sbjct: 1464 PPCKPLASASISQKNHLPQDS-QDLVLGGDVPISSIQATIAKLS-IRPPGGLESPVASLP 1521

Query: 379  ELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIP 438
              A PP  P        P + PE     + SPP     P+S P  +A +       P  P
Sbjct: 1522 GPAEPPGLP--------PASLPESTPIPSSSPP-----PLSSPLPEAPQPKEEPPVPEAP 1568

Query: 439  SATPATA 445
            S+ P ++
Sbjct: 1569 SSGPPSS 1575


>gi|169212085 PREDICTED: similar to poly(A) binding protein
           interacting protein 1 [Homo sapiens]
          Length = 516

 Score = 77.8 bits (190), Expect = 8e-14
 Identities = 78/337 (23%), Positives = 145/337 (43%), Gaps = 66/337 (19%)

Query: 683 PPRGGPGGELPRGPAGLG---------PRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKA 733
           P R  P G LP     L          P+++ +    +P+ ++A VL ++ + +N  E  
Sbjct: 115 PQRPSPPGALPEQTRSLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLRSK-LSVNAPEFY 173

Query: 734 WKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLT--PQMFQQLMKQVTQL---AI 788
               S       + G ED            V+  LN LT  P  F+  ++Q  +     +
Sbjct: 174 PSGYSSSYTESYEVGCEDYPTPSEY-----VQDFLNHLTEQPGSFETEIEQFAETLNGCV 228

Query: 789 DTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQ 848
            T++ L+ + +LI+++A S PNFS   A +C  L      + +      NFR+LLL RC+
Sbjct: 229 TTDDALQELAELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSG----NFRQLLLQRCR 284

Query: 849 KEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELF-K 907
            E+E                           +K++  +  ++ R+R    + F+GEL+  
Sbjct: 285 TEYE---------------------------VKDQAAKGDEVTRKRFHAFVFFLGELYLN 317

Query: 908 LKM-----------LTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDF---EKAKP 953
           L++           + +  + + +  L  N  +++L C  +LL   G  L+    EK K 
Sbjct: 318 LEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKM 377

Query: 954 RMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNW 990
            M++   ++E ++ +   S  ++ ML  +++LR SNW
Sbjct: 378 DMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNW 414


>gi|239752553 PREDICTED: similar to poly(A) binding protein
           interacting protein 1 [Homo sapiens]
          Length = 457

 Score = 77.8 bits (190), Expect = 8e-14
 Identities = 78/337 (23%), Positives = 145/337 (43%), Gaps = 66/337 (19%)

Query: 683 PPRGGPGGELPRGPAGLG---------PRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKA 733
           P R  P G LP     L          P+++ +    +P+ ++A VL ++ + +N  E  
Sbjct: 56  PQRPSPPGALPEQTRSLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLRSK-LSVNAPEFY 114

Query: 734 WKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLT--PQMFQQLMKQVTQL---AI 788
               S       + G ED            V+  LN LT  P  F+  ++Q  +     +
Sbjct: 115 PSGYSSSYTESYEVGCEDYPTPSEY-----VQDFLNHLTEQPGSFETEIEQFAETLNGCV 169

Query: 789 DTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQ 848
            T++ L+ + +LI+++A S PNFS   A +C  L      + +      NFR+LLL RC+
Sbjct: 170 TTDDALQELAELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSG----NFRQLLLQRCR 225

Query: 849 KEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELF-K 907
            E+E                           +K++  +  ++ R+R    + F+GEL+  
Sbjct: 226 TEYE---------------------------VKDQAAKGDEVTRKRFHAFVFFLGELYLN 258

Query: 908 LKM-----------LTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDF---EKAKP 953
           L++           + +  + + +  L  N  +++L C  +LL   G  L+    EK K 
Sbjct: 259 LEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKM 318

Query: 954 RMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNW 990
            M++   ++E ++ +   S  ++ ML  +++LR SNW
Sbjct: 319 DMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNW 355


>gi|89041275 PREDICTED: similar to poly(A) binding protein
           interacting protein 1 [Homo sapiens]
          Length = 488

 Score = 77.8 bits (190), Expect = 8e-14
 Identities = 78/337 (23%), Positives = 145/337 (43%), Gaps = 66/337 (19%)

Query: 683 PPRGGPGGELPRGPAGLG---------PRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKA 733
           P R  P G LP     L          P+++ +    +P+ ++A VL ++ + +N  E  
Sbjct: 87  PQRPSPPGALPEQTRSLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLRSK-LSVNAPEFY 145

Query: 734 WKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLT--PQMFQQLMKQVTQL---AI 788
               S       + G ED            V+  LN LT  P  F+  ++Q  +     +
Sbjct: 146 PSGYSSSYTESYEVGCEDYPTPSEY-----VQDFLNHLTEQPGSFETEIEQFAETLNGCV 200

Query: 789 DTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQ 848
            T++ L+ + +LI+++A S PNFS   A +C  L      + +      NFR+LLL RC+
Sbjct: 201 TTDDALQELAELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSG----NFRQLLLQRCR 256

Query: 849 KEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELF-K 907
            E+E                           +K++  +  ++ R+R    + F+GEL+  
Sbjct: 257 TEYE---------------------------VKDQAAKGDEVTRKRFHAFVFFLGELYLN 289

Query: 908 LKM-----------LTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDF---EKAKP 953
           L++           + +  + + +  L  N  +++L C  +LL   G  L+    EK K 
Sbjct: 290 LEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKM 349

Query: 954 RMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNW 990
            M++   ++E ++ +   S  ++ ML  +++LR SNW
Sbjct: 350 DMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNW 386


>gi|34452730 poly(A) binding protein interacting protein 1 isoform 3
           [Homo sapiens]
          Length = 367

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 72/300 (24%), Positives = 136/300 (45%), Gaps = 57/300 (19%)

Query: 711 EPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNK 770
           +P+ ++A VLM++ + +N  E      S       + G ED        L   V+  LN 
Sbjct: 3   KPQVVVAPVLMSK-LSVNAPEFYPSGYSSSYTESYEDGCEDYP-----TLSEYVQDFLNH 56

Query: 771 LT--PQMFQQLMKQVTQL---AIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAL 825
           LT  P  F+  ++Q  +     + T++ L+ +++LI+++A S PNFS   A +C  L   
Sbjct: 57  LTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHH 116

Query: 826 KVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELE 885
              + +      NFR+LLL RC+ E+E                           +K++  
Sbjct: 117 LTISPQSG----NFRQLLLQRCRTEYE---------------------------VKDQAA 145

Query: 886 EARDIARRRSLGNIKFIGELF-KLKM-----------LTEAIMHDCVVKLLKNHDEESLE 933
           +  ++ R+R    + F+GEL+  L++           + +  + + +  L  N  +++L 
Sbjct: 146 KGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLI 205

Query: 934 CLCRLLTTIGKDLDF---EKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNW 990
           C  +LL   G  L+    EK K  M++   ++E ++ +   S  ++ ML  +++LR SNW
Sbjct: 206 CAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNW 265


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 129/506 (25%), Positives = 176/506 (34%), Gaps = 98/506 (19%)

Query: 5    PQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQAT--QMNTPSQPRQHFYPSRAQPPSSA 62
            P S      P+   P PA P   T     + P +    +NTP            QP + A
Sbjct: 558  PVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPD--------GLVQPATPA 609

Query: 63   ASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPV 122
            A+  ++A      PA    PA S  +  P  +  P +Q     P         P    P 
Sbjct: 610  AATGEAAPVLTVQPAPQAPPAVSTPL--PLGLQQPQAQQPPQAP--------TPQAAAPP 659

Query: 123  QPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRI 182
            Q   P   PG + +          P + V   P    P  +L     Q+   +ER    +
Sbjct: 660  QATTPQPSPGLASS----------PEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPL 709

Query: 183  RDPNQGGKDITEEIMSGARTASTP---TPPQTGGGLEPQANG---------ETPQVAVIV 230
                         I+S    A  P   TP   G GL PQA           + P  A + 
Sbjct: 710  SAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLK 769

Query: 231  RPDDRSQGAI-----IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNL----- 280
             P   S  ++     + D P LP P  +   S+P S      P  V  P SEP L     
Sbjct: 770  GPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPS-----RPQSVSRPPSEPPLHPCPP 824

Query: 281  --AVLSIPGDTMTTIQMSVEE--STPISRETGEPYR-LSPEPTPLAEPILEVE----VTL 331
              A  ++PG  +   Q+ V    S P     G P   L P+  P   P+         + 
Sbjct: 825  PQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSST 884

Query: 332  SKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES- 390
            S  V  S  +SS L APTP +   ++     G   S    P +   PE A PP  P  + 
Sbjct: 885  SSAVASSSETSSRLPAPTP-SDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTF 943

Query: 391  -----PVPIAPTAQPEELLN----------------GAPSPP--AVDLSPVSEPEEQAKE 427
                 P P  P  QP+ LL                 GAP+ P  +  L P++ P   A  
Sbjct: 944  QMVTTPFPALP--QPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPA--ASV 999

Query: 428  VTASMAP---PTIPSATPATAPSATS 450
            + +  AP   PT PS  PA AP A +
Sbjct: 1000 LVSGQAPSGTPTAPSHAPAPAPMAAT 1025



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 142/615 (23%), Positives = 230/615 (37%), Gaps = 114/615 (18%)

Query: 4   APQST--GPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSS 61
           AP  T  G P A +PGL      P     ++  TP      TP QP+    P+   PP  
Sbjct: 315 APTGTPSGQPLAVAPGLGSSPLVPAPNV-ILHRTP------TPIQPK----PAGVLPPKL 363

Query: 62  AASRVQSAAPARPGPAAHVYPAG-SQVMMIPSQISYPASQGAYYIPGQG--RSTYVVPTQ 118
                +  APA         P    Q    P  +++ A+  A    GQ    S +  P  
Sbjct: 364 YQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKA----GQNVVLSGFPAPAL 419

Query: 119 QYPVQPGAPGFYPGASPTE-------------FGTYAGAYYPAQ----GVQQFPTGVAPA 161
           Q  V    P    GA+P +                 +    PAQ    G  QF    APA
Sbjct: 420 QANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPA 479

Query: 162 PVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANG 221
             L  Q   +      + +    P+ GG+ I   I++    A    P   G  L P +  
Sbjct: 480 VQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAG---PLSLGPVLAPHSGA 536

Query: 222 ETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLA 281
            +  + +   P    Q A+    P        P++SQP+   P  + + VL+  + P  A
Sbjct: 537 HSAHI-LSAAPIQVGQPALF-QMPVSLAAGSLPTQSQPAPAGP--AATTVLQGVTLPPSA 592

Query: 282 VLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFS 341
           V  +      T    V+ +TP +  TGE           A P+L V+     P P++   
Sbjct: 593 VAML-----NTPDGLVQPATPAAA-TGE-----------AAPVLTVQ-----PAPQA--- 627

Query: 342 SSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPE 401
             P    TPL         P G+   +  +P    +P+ A PP   +  P P    + PE
Sbjct: 628 --PPAVSTPL---------PLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSP-GLASSPE 675

Query: 402 ELLNGAP---SPPAV---DLSPVSEPEEQAKEVTASMAPP-TIPSATPATAPSATSPAQE 454
           +++ G P   +P A+   D   +  P+E++++  ++  P  ++P++   +AP    PAQ+
Sbjct: 676 KIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAP---PPAQD 732

Query: 455 EEMEEEEEEEEGEAGEAGEAESEKGGEELLP---------PESTP-----IPANLSQNLE 500
                   +  G   +A ++++       +P         P S+P      P   S +L 
Sbjct: 733 PAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLP 792

Query: 501 AAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVP---EVENQ---PPAGSNP 554
           +   T+     P R + +     +  +        +A P +P    ++NQ   PP  SNP
Sbjct: 793 SPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPP--PQAPPTLPGIFVIQNQLGVPPPASNP 850

Query: 555 GPESEGSGVPP-RPE 568
            P + G   PP RP+
Sbjct: 851 APTAPGPPQPPLRPQ 865



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 114/502 (22%), Positives = 170/502 (33%), Gaps = 95/502 (18%)

Query: 11  PPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQ--- 67
           PPA + G   P  P   + P+  S     Q ++   P QH  P + Q     A  VQ   
Sbjct: 427 PPATTTGAAPPQPPGALSKPM--SVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQ 484

Query: 68  --SAAPARPGP---AAHVYPAGSQVMMIP----SQISYPASQGAYYIPGQG-RSTYVVPT 117
             SA PA  G    AA     G Q++  P      ++ P S G    P  G  S +++  
Sbjct: 485 QLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSA 544

Query: 118 QQYPVQPGAPGFYPGASPTEFGTYAGAYYPA----------QGVQQFPTGVA----PAPV 163
              P+Q G P  +        G+      PA          QGV   P+ VA    P  +
Sbjct: 545 A--PIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGL 602

Query: 164 LMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGET 223
           +    P  A       + ++   Q    ++  +  G +      PPQ      P      
Sbjct: 603 VQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQA-----PTPQAAA 657

Query: 224 PQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTP---------------SP 268
           P  A   +P            PGL          QP S +PT                S 
Sbjct: 658 PPQATTPQPS-----------PGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQ 706

Query: 269 SPVLEPGSEPNLAVLSIPGDTMTTIQMSVEE---STPISRETG-EPYRLSPEPTPLAEPI 324
            P+   G       LS+P   + +     ++   +TP+++  G  P     + +P   P 
Sbjct: 707 QPLSAEGPH-----LSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQ 761

Query: 325 LEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIH--EPNGMVPSEDLEPEVESSPELAP 382
           +     L  P P S   S P QAP   + H    H   P    PS    P+  S P   P
Sbjct: 762 IPAAAPLKGPGPSSS-PSLPHQAPLGDSPHLPSPHPTRPPSRPPSR---PQSVSRPPSEP 817

Query: 383 P--PACPSESPVPIA-------------PTAQPEELLNGAPSPPAVDLSPVSEPEEQAKE 427
           P  P  P ++P  +              P + P      AP PP   L P S+P E    
Sbjct: 818 PLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPT---APGPPQPPLRPQSQPPEGPLP 874

Query: 428 VTASMAPPTIPSATPATAPSAT 449
               + P +  SA  +++ +++
Sbjct: 875 PAPHLPPSSTSSAVASSSETSS 896



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 151/614 (24%), Positives = 215/614 (35%), Gaps = 95/614 (15%)

Query: 11   PPAPSPGLPQ-----PAFPPGQ--------TAPVVFSTPQATQMNTPSQPRQHFYPSRAQ 57
            P AP+  LPQ     PA   GQ        T   + + P  T  N          P  A 
Sbjct: 475  PGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGP--LSLGPVLAP 532

Query: 58   PPSSAASRVQSAAPARPG-PAAHVYPAGSQVMMIPSQISYPASQG-AYYIPGQGRSTYVV 115
               + ++ + SAAP + G PA    P       +P+Q S PA  G A     QG     +
Sbjct: 533  HSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQ-SQPAPAGPAATTVLQG---VTL 588

Query: 116  PTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVA-PAPVLMNQP------ 168
            P     +     G    A+P      A      Q   Q P  V+ P P+ + QP      
Sbjct: 589  PPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPP 648

Query: 169  ----PQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLE---PQANG 221
                PQ A   +  T +   P+ G     E+I+ G   ++TPT   T   L+   PQ   
Sbjct: 649  QAPTPQAAAPPQATTPQ---PSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERS 705

Query: 222  ETPQVA-----------VIVRP---DDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPS 267
            + P  A           ++  P    D +    +A   GL GP+   S++ P+     P+
Sbjct: 706  QQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGL-GPQAPDSQASPAPAPQIPA 764

Query: 268  PSPVLEPG--SEPNLAVLSIPGDTM------TTIQMSVEESTP--ISRETGEPYRLSPEP 317
             +P+  PG  S P+L   +  GD+        T   S   S P  +SR   EP  L P P
Sbjct: 765  AAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEP-PLHPCP 823

Query: 318  TPLAEPILE----VEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPE 373
             P A P L     ++  L  P P S  + +P     P      +   P G +P     P 
Sbjct: 824  PPQAPPTLPGIFVIQNQLGVPPPAS--NPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPP 881

Query: 374  VESSPELAPPPACPSESPVPIAPTAQ----PEELLNGAPSPPAVDLSPVSEPEEQAKEVT 429
              +S  +A      S  P P     Q    P +  + +P+PP   L  V EP        
Sbjct: 882  SSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPT-LHLVPEPA------- 933

Query: 430  ASMAPPTIPSAT--PATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPE 487
               APP  P  T    T P    P  +  +E   +   G        +++ GG    P  
Sbjct: 934  ---APPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGII-----LQNKAGGAPAAPQT 985

Query: 488  STPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVG--DLLDAFKEANPA-VPEV 544
            ST +    S       + Q     P             A G   LL A  +A  + +P +
Sbjct: 986  STSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTL 1045

Query: 545  ENQPPAGSNPGPES 558
                 A S PG  S
Sbjct: 1046 NVAKAASSGPGKPS 1059



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 61/279 (21%), Positives = 90/279 (32%), Gaps = 49/279 (17%)

Query: 2    NKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSS 61
            N AP + GPP  P                     PQ+     P  P  H  PS      +
Sbjct: 849  NPAPTAPGPPQPP-------------------LRPQSQPPEGPLPPAPHLPPSSTSSAVA 889

Query: 62   AASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYP 121
            ++S   S  PA P P+               Q+ +P SQG +  P    + ++VP    P
Sbjct: 890  SSSETSSRLPA-PTPS-------------DFQLQFPPSQGPHKSPTPPPTLHLVPEPAAP 935

Query: 122  VQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQP--PQIAPKRERKT 179
              P    F    +P  F          +   Q P+G+    +L N+      AP+     
Sbjct: 936  PPPPPRTFQMVTTP--FPALPQPKALLERFHQVPSGI----ILQNKAGGAPAAPQTSTSL 989

Query: 180  IRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQ-ANGETPQVAVIVRPDDRSQG 238
              +  P          ++SG   + TPT P       P  A G  P +    +    +  
Sbjct: 990  GPLTSP------AASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLP 1043

Query: 239  AIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSE 277
             +   +    GP   PS  Q  S        P L+P  E
Sbjct: 1044 TLNVAKAASSGP-GKPSGLQYESKLSGLKKPPTLQPSKE 1081



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 82/378 (21%), Positives = 126/378 (33%), Gaps = 64/378 (16%)

Query: 231  RPDD-----RSQGA-IIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEP---------G 275
            +PD+     RS G  I A   G   P H P  S  S+P  +  P P L           G
Sbjct: 1197 KPDEYVSSSRSLGLPIAASSEGHRLPGHGPLSS--SAPGASTQPPPHLPTKLVIRHGGAG 1254

Query: 276  SEPNL-------AVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPI-LEV 327
              P++       ++ S    +     +  +E  P+      P +     + +   + ++ 
Sbjct: 1255 GSPSVTWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQ 1314

Query: 328  EVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACP 387
            E  LSK V  +     P+  P P  + T+++ EP    P         +     PPPA P
Sbjct: 1315 EAGLSKVVHNTALD--PVHQPPPPPA-TLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAP 1371

Query: 388  SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 447
               P            L  AP  P + L          K    ++  P  P  TPA    
Sbjct: 1372 ERKP------------LGTAPHCPRLPL---------RKTYRENVGGPGAPEGTPAGRAR 1410

Query: 448  ATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQV 507
              SPA      + +E   G   E    E E     L  P   P PA  +         + 
Sbjct: 1411 GGSPAPLP--AKVDEATSGLIRELAAVEDELYQRMLKGP--PPEPAASAAQGTGDPDWEA 1466

Query: 508  AVSVPKRRRKIKELNKKEAV--------GDLLDAFKEANPAVPEVENQP---PAGSNPGP 556
                P +RRK +  +  +A           L +  + A  ++  ++  P   PA S P  
Sbjct: 1467 PGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHA 1526

Query: 557  ESEGSGVPPRPEEADETW 574
             S G+   P P    E +
Sbjct: 1527 ASAGTPASPPPLHRPEAY 1544


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.130    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,278,230
Number of Sequences: 37866
Number of extensions: 4655385
Number of successful extensions: 59037
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 434
Number of HSP's successfully gapped in prelim test: 2065
Number of HSP's that attempted gapping in prelim test: 29736
Number of HSP's gapped (non-prelim): 20133
length of query: 1599
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1483
effective length of database: 13,855,062
effective search space: 20547056946
effective search space used: 20547056946
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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