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Search of human proteins with 37221175
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|37221175 PH domain and leucine rich repeat protein
phosphatase [Homo sapiens]
(1205 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 2420 0.0
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 1290 0.0
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 145 2e-34
gi|238908508 leucine-rich repeat and death domain-containing pro... 133 1e-30
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 128 3e-29
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 110 6e-24
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 110 6e-24
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 107 9e-23
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 107 9e-23
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 96 2e-19
gi|45827729 scribble isoform b [Homo sapiens] 94 8e-19
gi|45827731 scribble isoform a [Homo sapiens] 94 8e-19
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 94 8e-19
gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens] 94 1e-18
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 94 1e-18
gi|225579152 insulin-like growth factor binding protein, acid la... 93 2e-18
gi|4826772 insulin-like growth factor binding protein, acid labi... 93 2e-18
gi|4503743 flightless I homolog [Homo sapiens] 92 3e-18
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 91 7e-18
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 88 4e-17
gi|19923729 leucine rich repeat containing 8 family, member C [H... 87 7e-17
gi|45505137 podocan [Homo sapiens] 87 1e-16
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 85 4e-16
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 85 4e-16
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 85 5e-16
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 84 6e-16
gi|40217803 leucine rich repeat containing 8 family, member E [H... 84 6e-16
gi|7706093 toll-like receptor 7 [Homo sapiens] 83 1e-15
gi|197333706 leucine rich repeat containing 8 family, member D [... 82 2e-15
gi|34222199 leucine rich repeat containing 8 family, member D [H... 82 2e-15
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 2420 bits (6271), Expect = 0.0
Identities = 1205/1205 (100%), Positives = 1205/1205 (100%)
Query: 1 MDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVS 60
MDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVS
Sbjct: 1 MDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVS 60
Query: 61 SVKDSLTGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVS 120
SVKDSLTGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVS
Sbjct: 61 SVKDSLTGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVS 120
Query: 121 KVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTK 180
KVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTK
Sbjct: 121 KVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTK 180
Query: 181 LKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSL 240
LKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSL
Sbjct: 181 LKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSL 240
Query: 241 PAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHV 300
PAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHV
Sbjct: 241 PAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHV 300
Query: 301 DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGY 360
DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGY
Sbjct: 301 DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGY 360
Query: 361 FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420
FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL
Sbjct: 361 FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420
Query: 421 PARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLN 480
PARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLN
Sbjct: 421 PARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLN 480
Query: 481 ASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFP 540
ASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFP
Sbjct: 481 ASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFP 540
Query: 541 ASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDL 600
ASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDL
Sbjct: 541 ASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDL 600
Query: 601 SCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQPSTGDASGAPA 660
SCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQPSTGDASGAPA
Sbjct: 601 SCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQPSTGDASGAPA 660
Query: 661 VWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEE 720
VWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEE
Sbjct: 661 VWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEE 720
Query: 721 LQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQ 780
LQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQ
Sbjct: 721 LQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQ 780
Query: 781 TVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVV 840
TVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVV
Sbjct: 781 TVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVV 840
Query: 841 PRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCH 900
PRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCH
Sbjct: 841 PRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCH 900
Query: 901 DSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSG 960
DSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSG
Sbjct: 901 DSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSG 960
Query: 961 MASEISSELSTSEMSSEVGSTASDEPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLS 1020
MASEISSELSTSEMSSEVGSTASDEPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLS
Sbjct: 961 MASEISSELSTSEMSSEVGSTASDEPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLS 1020
Query: 1021 SATFSSAFSDNGLDSDDEEPIEGVFTNGSRVEVEVDIHCSRAKEKEKQQHLLQVPAEASD 1080
SATFSSAFSDNGLDSDDEEPIEGVFTNGSRVEVEVDIHCSRAKEKEKQQHLLQVPAEASD
Sbjct: 1021 SATFSSAFSDNGLDSDDEEPIEGVFTNGSRVEVEVDIHCSRAKEKEKQQHLLQVPAEASD 1080
Query: 1081 EGIVISANEDEPGLPRKADFSAVGTIGRRRANGSVAPQERSHNVIEVATDAPLRKPGGYF 1140
EGIVISANEDEPGLPRKADFSAVGTIGRRRANGSVAPQERSHNVIEVATDAPLRKPGGYF
Sbjct: 1081 EGIVISANEDEPGLPRKADFSAVGTIGRRRANGSVAPQERSHNVIEVATDAPLRKPGGYF 1140
Query: 1141 AAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDY 1200
AAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDY
Sbjct: 1141 AAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDY 1200
Query: 1201 YDTPL 1205
YDTPL
Sbjct: 1201 YDTPL 1205
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 1290 bits (3337), Expect = 0.0
Identities = 664/1223 (54%), Positives = 878/1223 (71%), Gaps = 50/1223 (4%)
Query: 4 EIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVK 63
++GC+IRFY KP +RI LSG+YNVRKGK QL ++W R V+LCGTCLIVSSVK
Sbjct: 130 DLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQL--HKWAERLVVLCGTCLIVSSVK 187
Query: 64 DSLTGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVA 123
D TGKMH+LPL+GGK+EEVK+ Q+ LAFSS+G Q+QTY++ F+T EY RW RQ SKV
Sbjct: 188 DCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVV 247
Query: 124 SQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKS 183
SQRIS+VDLSC SLE +P +LFYSQD+T+LNL+ NF++ L GL+ L +F++LK
Sbjct: 248 SQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ----LERPGGLDTLYKFSQLKG 303
Query: 184 LNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAE 243
LNLS+N LG FP+ +C I TL ELN+SCN +P+ +G + NLQT LDGNFL +LP E
Sbjct: 304 LNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEE 363
Query: 244 LENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLR 303
L N++QLS LG+SFN F+ IPEV EKLT +D++ M+GNC+E L L L +M HIKHVDLR
Sbjct: 364 LGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLR 423
Query: 304 LNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLK 363
+N ++ ++ + ++ +H+T +DLRDN+L DLD ++E LHC RNQL L + G+ L+
Sbjct: 424 MNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLR 483
Query: 364 ALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPAR 423
LYASSN L ++VYPVP+ L+++D+SRN LE VP+W CE++K+EVLD+ +N + E+P R
Sbjct: 484 TLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVR 543
Query: 424 LFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASA 483
+ + SLRKL+ GHN + LP +E +EVLD+QHN L LP L KA +LR+LNASA
Sbjct: 544 ILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASA 603
Query: 484 NKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASK 543
N LESLP A EE+ S+LQ LYLTNN LTD+C+P+L GH HL+ILH+A N+LQ+FPASK
Sbjct: 604 NSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASK 663
Query: 544 MAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCN 603
+ KLE+LEE++LSGNKLK IPTTI NC+R+HT++AHSN I +FPE++QLP+I+ VDLSCN
Sbjct: 664 LNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCN 723
Query: 604 ELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQP--STGDASGAPAV 661
+L+E+ +PE LP LQ+LDLTGN LVL+HKTL++ ++I KIDQ T D++
Sbjct: 724 DLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTF 783
Query: 662 WSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEEL 721
WSHG E +G +NKLCV+AL++++F + A+YG+FDGDRN E+P LLQCTM+D+L EE+
Sbjct: 784 WSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEV 843
Query: 722 QKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQT 781
Q++ N+ +M NTF+V RKLG AGQKLG +A+LC+I+ D DP SF+LT ANVG CQ
Sbjct: 844 QQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQA 903
Query: 782 VLCRNGKPLPLSRSYIMSCE-EELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVV 840
VLCR GKP+PLS+ + + + EE +R+K KAIITED KVNGVT TR+LG T+L+P ++
Sbjct: 904 VLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWIL 963
Query: 841 PRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCH 900
P+PH+ S LT QDE ILG+K LW+ LS EAV AVR+V D LAAAKKLCTLAQSYGC
Sbjct: 964 PKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQ 1023
Query: 901 DSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSG 960
D++ A+VV L++ E+ C CE++ + P P F + IKD P PSSSSG
Sbjct: 1024 DNVGAMVVYLNIGEEG-CTCEMN---GLTLPGPVGFASTT--TIKDAPKP--ATPSSSSG 1075
Query: 961 MASEISSELSTSEMSSEVGSTASDEPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLS 1020
+ASE SSE+STSE+SSEVGSTASDE G L P E+RC LHP S FQRQ S
Sbjct: 1076 IASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRP-ERRCSLHPTPTSGLFQRQPS 1134
Query: 1021 SATFSSAFSDNGLDSDDEEPIEGVFTNGSRVEVEVDIHCSRAKEKEKQQHLLQ-VPAEAS 1079
SATFSS SDNGLDSDD++P+EGV TNGS+VEVEVDIHC R ++ E L++ P S
Sbjct: 1135 SATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCS 1194
Query: 1080 DE-----------------GIVISANEDEPGLPRKADFSAVGTIGRRRANGSVAPQERSH 1122
+E G+++ ++D L + S + G++ +NGS+ P E S
Sbjct: 1195 EEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCL--YGKKLSNGSIVPLEDSL 1252
Query: 1123 NVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQPPPPP 1182
N+IEVAT+ P RK GYFAAP Q +P+DQF++P +LEEEVKE MK HQ+ + + +P
Sbjct: 1253 NLIEVATEVPKRKT-GYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEED 1311
Query: 1183 QLQPQLPRHYQLDQLPDYYDTPL 1205
+ +P P+ +DT L
Sbjct: 1312 RTEP-----------PEEFDTAL 1323
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 145 bits (366), Expect = 2e-34
Identities = 134/476 (28%), Positives = 235/476 (49%), Gaps = 35/476 (7%)
Query: 161 RQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAA 220
+++ + + LN+ + ++ L+LS + P ++ + L EL + N L+S+PA
Sbjct: 83 KKSSNAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE 141
Query: 221 VGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSG 280
VG + NL T L N L SLP L+N+K+L L L N+ +IP V+ +L ++ L +
Sbjct: 142 VGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRF 201
Query: 281 NCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFN 340
N + T+ + ++ + + + +R N I++L A E+ L ++ LD+ N+L L
Sbjct: 202 NRITTVE-KDIKNLSKLSMLSIRENKIKQLPA-EIGELCNLITLDVAHNQLEHLPK---- 255
Query: 341 NIEVLHCERNQLVTLDICGYFLKALYASSNELVQL-DVYPVPNYLSYMDVSRNRLENVPE 399
E+ +C Q+ LD+ NEL+ L D + LS + + NRL +P
Sbjct: 256 --EIGNC--TQITNLDL----------QHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPR 301
Query: 400 WVCESRKLEVLDIGHNQICELPARLFCN-SSLRKLLAGHN--QLARLPERLERTSVEVLD 456
+ + LE L++ +N I LP L + L L N QL + + +++ L+
Sbjct: 302 SLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLN 361
Query: 457 VQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKC 516
++HN++ ++P + +A L LN N+L SLP L T + + EL L N LT K
Sbjct: 362 MEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP---LDFGTWTSMVELNLATNQLT-KI 417
Query: 517 VPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTV 576
++G L++L ++ N L+ P + L +L E+DL NKL+++P I + + +
Sbjct: 418 PEDVSGLVSLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKDLQKL 476
Query: 577 IAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELDLTGNPRL 629
+ +N + P + L + + L N L+ LPE + L+EL L NP L
Sbjct: 477 VLTNNQLTTLPRGIGHLTNLTHLGLGENLLTH--LPEEIGTLENLEELYLNDNPNL 530
Score = 131 bits (329), Expect = 4e-30
Identities = 141/487 (28%), Positives = 243/487 (49%), Gaps = 46/487 (9%)
Query: 116 LRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNEL 175
+++++K + +DLS S+ LP+++ LT L L N L+ SLPA E+
Sbjct: 91 IKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQ---SLPA-----EV 142
Query: 176 QRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGN 235
L +L LS N L P ++ ++ L L++ N LR +P+ V + +L T L N
Sbjct: 143 GCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
Query: 236 FLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMP 295
+ ++ +++N+ +LS L + N+ +P + +L + L ++ N +E L + +
Sbjct: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP-KEIGNCT 261
Query: 296 HIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLV 353
I ++DL+ N + L D + L +++L LR N+L + + + +E L+ E N +
Sbjct: 262 QITNLDLQHNELLDL-PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Query: 354 TLDICGYFLKALYASSNELVQL-------DVYPV--PNYLS---YMDVSRNRLENVPEWV 401
TL ++L +S +L L +YPV P+ S +++ NR+ +P +
Sbjct: 321 TLP------ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGI 374
Query: 402 CESRK-LEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE-RTSVEVLDVQH 459
K L L++ NQ+ LP +S+ +L NQL ++PE + S+EVL + +
Sbjct: 375 FSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSN 434
Query: 460 NQLLELPPNLLMKADSLRFLNASANKLESLPP--ATLSEETNSILQELYLTNNSLTDKCV 517
N L +LP L LR L+ NKLESLP A L + LQ+L LTNN LT +
Sbjct: 435 NLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKD-----LQKLVLTNNQLT--TL 486
Query: 518 PLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGN-KLKAIPTTIMNCRRMHT 575
P GH +L L + N L P ++ LE LEE+ L+ N L ++P + C ++ +
Sbjct: 487 PRGIGHLTNLTHLGLGENLLTHLP-EEIGTLENLEELYLNDNPNLHSLPFELALCSKL-S 544
Query: 576 VIAHSNC 582
+++ NC
Sbjct: 545 IMSIENC 551
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 133 bits (334), Expect = 1e-30
Identities = 132/502 (26%), Positives = 238/502 (47%), Gaps = 33/502 (6%)
Query: 153 LNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCN 212
L+L++N L PS E+Q L+ LN+S+NH+ P + + + +L N
Sbjct: 193 LSLQENGLSSLPS--------EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
Query: 213 ALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTA 272
+ + P+ + + NL+ L N L+ +P L ++K L L L +N+ T P+ L L
Sbjct: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
Query: 273 VDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL--IADEVDFLQHVTQLDLRDNK 330
+ L ++GN + +L +++ +K+++ L KL +A E+ L + +L L DNK
Sbjct: 305 LISLDLTGNLISSLP----KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
Query: 331 LGDLDAMI--FNNIEVLHCERNQLVTLD---ICGYFLKALYASSNELVQLDVY-PVPNYL 384
L + I F + +L ++N L + C L+ L S N+L +L Y N L
Sbjct: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420
Query: 385 SYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLP 444
+ V+RN + + + + + L+ N I ++P + + K+ +N++ P
Sbjct: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480
Query: 445 ERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQ 503
L S+ L V N + E+P ++ + L L S NKL SE S++
Sbjct: 481 LGLCALDSLYYLSVNGNYISEIPVDISF-SKQLLHLELSENKL-----LIFSEHFCSLIN 534
Query: 504 ELYLTNNSLTDKCVPL-LTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKA 562
YL K +P ++ L +L + N+ ++FP ++ LE L+ +DLS N+L+
Sbjct: 535 LKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP-RELCTLENLQVLDLSENQLQK 593
Query: 563 IPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVT-LPENLP--PKL 618
I + I N + + + SN FP E+ QL ++ +++S + ++T LP L +L
Sbjct: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653
Query: 619 QELDLTGNPRLVLDHKTLELLN 640
+ELD++ N + EL N
Sbjct: 654 KELDISNNAIREIPRNIGELRN 675
Score = 131 bits (329), Expect = 4e-30
Identities = 134/492 (27%), Positives = 222/492 (45%), Gaps = 78/492 (15%)
Query: 137 LEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPL 196
+E+ P++L +L L+L +N LR P + L L+ LNL N L FP
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIP--------DTLPSLKTLRVLNLEYNQLTTFPK 297
Query: 197 AVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL------------ 244
A+C +P L L+++ N + S+P + + NL+T L+D N L L E+
Sbjct: 298 ALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLA 357
Query: 245 -----------ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETL-----RL 288
EN ++L L L N +IPE + ++ L +S N + L +L
Sbjct: 358 DNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417
Query: 289 QALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCE 348
LRK+ HV+ R N+++ I D + L ++ L+ N + D+ I N +++ E
Sbjct: 418 NNLRKL----HVN-RNNMVK--ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIE 470
Query: 349 R--NQLVTLDICGYFLKALYASSNELVQLDVYPVP----NYLSYMDVSRNRLENVPEWVC 402
N+++ + L +LY S + PV L ++++S N+L E C
Sbjct: 471 LSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFC 530
Query: 403 ESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQ 461
L+ LD+G NQI ++PA + SL L+ N+ P L +++VLD+ NQ
Sbjct: 531 SLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590
Query: 462 LLELPPNL----------------------LMKADSLRFLNASANKLESLP--PATLSEE 497
L ++ ++ L + SL LN S K L P LS
Sbjct: 591 LQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNM 650
Query: 498 TNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSG 557
T L+EL ++NN++ + +P G + AYN S+ + L +L++++LSG
Sbjct: 651 TQ--LKELDISNNAIRE--IPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706
Query: 558 NKLKAIPTTIMN 569
N L A+P+ I N
Sbjct: 707 NNLTALPSAIYN 718
Score = 84.3 bits (207), Expect = 6e-16
Identities = 98/436 (22%), Positives = 185/436 (42%), Gaps = 67/436 (15%)
Query: 126 RISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLN 185
+I + L+ LE + + ++L L L +N L+ P ++ L+ L+
Sbjct: 350 KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPE--------KISCCAMLECLS 401
Query: 186 LSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELE 245
LS+N L + P + + L +L+V+ N + + + ++N+ + GN + +P E++
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
Query: 246 NMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRL----------------- 288
N +++ + LS+N+ P L L ++ L ++GN + + +
Sbjct: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENK 521
Query: 289 -----QALRKMPHIKHVDLRLNVIRKLIADEVDFLQ-HVTQLDLRDNKLGDLDAMIFNNI 342
+ + ++K++DL N I+K+ A + + HV L + + N+
Sbjct: 522 LLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENL 581
Query: 343 EVLHCERNQL--VTLDICGYF-LKALYASSNELV-------------QLDVYPV------ 380
+VL NQL ++ DIC ++ L SSN+ + QL++ +
Sbjct: 582 QVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLT 641
Query: 381 --PNYLSYM------DVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRK 432
P LS M D+S N + +P + E R L L +NQI LP L + L++
Sbjct: 642 RLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQ 701
Query: 433 LLAGHNQLARLPERLERT-SVEVLDVQHNQLLELPPNLLMKADSL----RFLNASANKLE 487
L N L LP + S++ ++ N LL PP + K L R+L + + E
Sbjct: 702 LNLSGNNLTALPSAIYNIFSLKEINFDDNPLLR-PPVEICKGKQLYTIARYLQRADERDE 760
Query: 488 SLPPATLSEETNSILQ 503
+ N+I +
Sbjct: 761 KILEKIFKIVANNITE 776
Score = 79.3 bits (194), Expect = 2e-14
Identities = 96/411 (23%), Positives = 173/411 (42%), Gaps = 51/411 (12%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
Q+I ++LS + + P L L +L++ N++ + P ++ +L L
Sbjct: 464 QKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPV--------DISFSKQLLHL 515
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
LS N L F CS+ L L++ N ++ +PA++ M +L +L N ++ P EL
Sbjct: 516 ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPREL 575
Query: 245 ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGN-----CVETLRLQALRKMPHIKH 299
++ L L LS N+ I + L + KL S N +E +LQ+L ++ +I
Sbjct: 576 CTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQL-NISQ 634
Query: 300 VDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTLDI 357
+ R + R + E+ + + +LD+ +N + ++ I N+ LH NQ+
Sbjct: 635 IKGR-KLTR--LPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQI----- 686
Query: 358 CGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQI 417
+L S N+L QL ++S N L +P + L+ ++ N +
Sbjct: 687 --SYLPPSLLSLNDLQQL------------NLSGNNLTALPSAIYNIFSLKEINFDDNPL 732
Query: 418 CELPARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLR 477
P + C ++L L R ER E+ ++ + N + E N L
Sbjct: 733 LRPPVEI-CKG--KQLYTIARYLQRADERDEKILEKIFKIVANNITE--TNFEFLCQKLN 787
Query: 478 FLNASANKLESLPPATLSEETNSIL-------QELYLTNNSLTDKCVPLLT 521
N S + + +LSE + L +L LT +L D+ + LT
Sbjct: 788 LAN-SETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALT 837
Score = 50.8 bits (120), Expect = 8e-06
Identities = 55/219 (25%), Positives = 90/219 (41%), Gaps = 48/219 (21%)
Query: 106 FDTFTEYLRWLR--QVSKVASQRISSVDLSCCSLE-------------HLPANLFYSQDL 150
F+TF L L QV ++ ++ + C+L+ H P L Q L
Sbjct: 568 FETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSL 627
Query: 151 THLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPL-------------- 196
LN+ Q R+ LP EL T+LK L++SNN + + P
Sbjct: 628 EQLNISQIKGRKLTRLPG-----ELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682
Query: 197 ---------AVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENM 247
++ S+ L +LN+S N L ++P+A+ + +L+ D N L P E+
Sbjct: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKG 742
Query: 248 KQLSYLGLSFNEFTDIPE-VLEKLTAVDKLCMSGNCVET 285
KQL + + E +LEK+ + ++ N ET
Sbjct: 743 KQLYTIARYLQRADERDEKILEKIFKI----VANNITET 777
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 128 bits (322), Expect = 3e-29
Identities = 133/484 (27%), Positives = 227/484 (46%), Gaps = 55/484 (11%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHL-NLKQNFLRQNPSLPAARGLNELQRFTKLKS 183
+ + +++S L+ LP +++T+L NLK +L+ N + G +L + L+
Sbjct: 128 ENLQKLNVSHNKLKILP------EEITNLRNLKCLYLQHNELTCISEGFEQL---SNLED 178
Query: 184 LNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAE 243
L+LSNNHL P + S+ +L LN+S N L+S+PA + M L+ + N L+++P E
Sbjct: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPE 238
Query: 244 LENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLR 303
L M+ L L L N+ +PE + + +L + N +E L + L+ + I +DLR
Sbjct: 239 LAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLR 297
Query: 304 LNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFN-NIEVLHCERNQLVTLDICGYFL 362
N + K + DE+ L+ + +LDL +N + L + N +++ L E N L T+
Sbjct: 298 DNKL-KSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTI------- 349
Query: 363 KALYASSNELVQLDVYPVPNYL--SYMDVSRNRLENVPEWV----CESR-------KLEV 409
E++ V YL D ++ E+ E ESR L++
Sbjct: 350 ------RREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKI 403
Query: 410 LDIGHNQICELPARLF---CNSSLRKLLAGHNQLARLPERLE--RTSVEVLDVQHNQLLE 464
LD Q +P +F ++ + + NQL +P+R+ + V +D+ N+L
Sbjct: 404 LDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSF 463
Query: 465 LPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI--LQELYLTNNSLTDKCVP-LLT 521
+ L + L FL+ N L SLP EE S+ LQ + L+ N K +P +L
Sbjct: 464 ISLELCV-LQKLTFLDLRNNFLNSLP-----EEMESLVRLQTINLSFNRF--KMLPEVLY 515
Query: 522 GHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSN 581
L+ + ++ N++ S KM +E L +DL N L IP + NC + T++ N
Sbjct: 516 RIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Query: 582 CIEV 585
V
Sbjct: 576 PFRV 579
Score = 122 bits (307), Expect = 2e-27
Identities = 119/479 (24%), Positives = 228/479 (47%), Gaps = 33/479 (6%)
Query: 179 TKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQ 238
T L L +SNN L + +P L L++ N L S+P+A+ + NLQ + N L+
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 239 SLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIK 298
LP E+ N++ L L L NE T I E E+L+ ++ L +S N + T+ + + +
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVP-ASFSSLSSLV 200
Query: 299 HVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTL- 355
++L N ++ L A E++ ++ + LD N L + + ++E+L+ RN+L L
Sbjct: 201 RLNLSSNELKSLPA-EINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Query: 356 --DICGYFLKALYASSNELVQLDVYPVP--NYLSYMDVSRNRLENVPEWVCESRKLEVLD 411
C LK L+ N++ L+ + N + +D+ N+L++VP+ + R LE LD
Sbjct: 260 EFPSCS-LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
Query: 412 IGHNQICELPARLFCNSSLRKLLAGHNQLARL-PERLERTSVEVLDVQHNQLLELPPNLL 470
+ +N I LP L N L+ L N L + E + + + EVL +++ + P+
Sbjct: 319 LSNNDISSLPYSL-GNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQS 377
Query: 471 MKAD------------------SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSL 512
A +L+ L+ S + +P ++I+ + + N L
Sbjct: 378 ESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQL 437
Query: 513 TDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRR 572
+ ++ + + +++N+L SF + ++ L++L +DL N L ++P + + R
Sbjct: 438 CEIPKRMVELKEMVSDVDLSFNKL-SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
Query: 573 MHTVIAHSNCIEVFPEVM-QLPEIKCVDLSCNELSEVTLPE-NLPPKLQELDLTGNPRL 629
+ T+ N ++ PEV+ ++ ++ + +S N++ V + + L LDL N L
Sbjct: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLL 555
Score = 50.8 bits (120), Expect = 8e-06
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 174 ELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLD 233
EL KL L+L NN L P + S+ L +N+S N + +P + + L+T L+
Sbjct: 467 ELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILIS 526
Query: 234 GNFLQSL-PAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALR 292
N + S+ P +++ M+ L+ L L N+ IP L + L + GN R L
Sbjct: 527 NNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM 586
Query: 293 K 293
K
Sbjct: 587 K 587
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 110 bits (276), Expect = 6e-24
Identities = 131/508 (25%), Positives = 227/508 (44%), Gaps = 56/508 (11%)
Query: 136 SLEHLPANLFYSQDLTHLNLKQNFL-RQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDF 194
S+EH P + D H+N + F+ N SL A E+ FT+L+ ++L NN + +
Sbjct: 7 SVEHSP-KIHQRNDPQHVNDRTFFIDASNQSLTAIP--LEIFTFTELEEVHLENNQIEEI 63
Query: 195 PLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGN-FLQSLPAELENMKQLSYL 253
P + + + L + N LRS+ A+G++ +L++ L N S + + L L
Sbjct: 64 PQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALREL 123
Query: 254 GLSFNEFTDIPEVLEK-LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIA 312
L + +IP V+ K L ++ L ++GN ++ L + + + ++ + L+ N ++
Sbjct: 124 RLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQ-TKLREIYLKRNQF-EVFP 181
Query: 313 DEVDFLQHVTQLDLRDNKLGDLDA------------MIFNNIEVLH---CERNQLVTLDI 357
E+ L + +DL +NK+G + M NN+ VL C+ +QL LD+
Sbjct: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
Query: 358 CGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQI 417
L ++ S EL ++ + +S NRLE VP +C L +L +G+ +
Sbjct: 242 SHNLLHSIPKSFAEL---------RKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGL 292
Query: 418 CELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQLLELPPNLLMKADSL 476
L C +LR L N L P ++ ++EVL + N++ +LP L L
Sbjct: 293 HRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSE-LGSLSKL 351
Query: 477 RFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPH------LKILH 530
+ L + N+ S P LS + L++LY+ D+ L H LK L+
Sbjct: 352 KILGLTGNEFLSFPEEVLSLAS---LEKLYIGQ----DQGFKLTYVPEHIRKLQSLKELY 404
Query: 531 MAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVM 590
+ N L+ P S + + LE +D N LK +P I + + + N + PE +
Sbjct: 405 IENNHLEYLPVS-LGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
Query: 591 -QLPEIKCVDLSCNELSEVTLPENLPPK 617
L +K + L N + E PPK
Sbjct: 464 DSLVNLKVLTLMDNPMEE-------PPK 484
Score = 97.1 bits (240), Expect = 9e-20
Identities = 96/384 (25%), Positives = 174/384 (45%), Gaps = 44/384 (11%)
Query: 137 LEHLPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFP 195
L+ +P +F + L L L N L+ P E+ TKL+ + L N FP
Sbjct: 130 LKEIPVVIFKNLHHLELLGLTGNHLKCLPK--------EIVNQTKLREIYLKRNQFEVFP 181
Query: 196 LAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGL 255
+C + TL +++ N + ++P +G + LQ F + N L LPA L QLS L L
Sbjct: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
Query: 256 SFNEFTDIPEVLEKLTAVDKLCMSGNCVETL---------------------RLQ-ALRK 293
S N IP+ +L + ++ +SGN +E + RL+ + R
Sbjct: 242 SHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRC 301
Query: 294 MPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQ 351
+ +++ +DL N + ++ L+++ L L DNK+G L + + + +++L N+
Sbjct: 302 LVNLRFLDLSQNHLHHCPL-QICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNE 360
Query: 352 LVTLD---ICGYFLKALYASSNELVQLDVYPVP----NYLSYMDVSRNRLENVPEWVCES 404
++ + L+ LY ++ +L P L + + N LE +P +
Sbjct: 361 FLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM 420
Query: 405 RKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLER-TSVEVLDVQHNQLL 463
LEVLD HN + +LP + +L++L N L LPE L+ +++VL + N +
Sbjct: 421 PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME 480
Query: 464 ELPPNLLMKADSL--RFLNASANK 485
E P + + + ++L + N+
Sbjct: 481 EPPKEVCAEGNEAIWKYLKENRNR 504
Score = 92.0 bits (227), Expect = 3e-18
Identities = 110/481 (22%), Positives = 213/481 (44%), Gaps = 36/481 (7%)
Query: 207 LNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEV 266
++ S +L ++P + L+ L+ N ++ +P E++ +K + L L N +
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 267 LEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDL 326
L L++++ L +S N + + L + + ++ + L ++++ L H+ L L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 327 RDNKLGDLDAMIFNNIEV--LHCERNQLVTLDICGYFLKALYASSNELVQLD---VYPVP 381
N L L I N ++ ++ +RNQ ++ L LY + E++ LD + +P
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQ---FEVFPQELCVLY--TLEIIDLDENKIGAIP 204
Query: 382 NYLSYMD------VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLA 435
+ ++ ++ N L +P +C+ +L VLD+ HN + +P + ++
Sbjct: 205 EEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
Query: 436 GHNQLARLPERLER-TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATL 494
N+L ++P + R TS+ +L + + L L + +LRFL+ S N L P
Sbjct: 265 SGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLV-NLRFLDLSQNHLHHCPLQIC 323
Query: 495 SEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPAS--KMAKLEELEE 552
+ + L+ L L +N + + L LKIL + N SFP +A LE+L
Sbjct: 324 ALKN---LEVLGLDDNKI-GQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYI 379
Query: 553 IDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLP 611
G KL +P I + + + +N +E P + +P ++ +D N L ++
Sbjct: 380 GQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDA 439
Query: 612 ENLPPKLQELDLTGNPRLVLDH--KTLELLNNIRCFKI------DQPSTGDASGAPAVWS 663
L+EL L N +L H + L+ L N++ + + P A G A+W
Sbjct: 440 ICQAQALKELRLEDN---LLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWK 496
Query: 664 H 664
+
Sbjct: 497 Y 497
Score = 58.2 bits (139), Expect = 5e-08
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 11/160 (6%)
Query: 130 VDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNN 189
+DLS L H P + ++L L L N + Q PS EL +KLK L L+ N
Sbjct: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPS--------ELGSLSKLKILGLTGN 359
Query: 190 HLGDFPLAVCSIPTLAELNVSCN---ALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELEN 246
FP V S+ +L +L + + L VP + + +L+ ++ N L+ LP L +
Sbjct: 360 EFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGS 419
Query: 247 MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETL 286
M L L N +P+ + + A+ +L + N + L
Sbjct: 420 MPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHL 459
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 110 bits (276), Expect = 6e-24
Identities = 116/408 (28%), Positives = 196/408 (48%), Gaps = 29/408 (7%)
Query: 124 SQRISSVDLSCCSLEHLPANLF-YSQDLTHLNLKQNFLRQNPS----LPAARGL----NE 174
++ + S+D CSL ++P ++ Y++ L L L N LR+ P L R L NE
Sbjct: 11 NRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNE 70
Query: 175 LQR-------FTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNL 227
+QR F +L L++S N + + P ++ L + S N L +P + + NL
Sbjct: 71 IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
Query: 228 QTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLR 287
++ LQSLP + N+ L+ L L N T +P+ L +L +++L + N + L
Sbjct: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
Query: 288 LQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVL 345
+++ + H+K + L N + +L E+ L+++ LD+ +N+L L I ++ L
Sbjct: 191 -ESIGALLHLKDLWLDGNQLSEL-PQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDL 248
Query: 346 HCERNQLVTL-DICGYF--LKALYASSNELVQL-DVYPVPNYLSYMDVSRNRLENVPEWV 401
+N L T+ D G L L N L QL + L+ + ++ N+L +P+ +
Sbjct: 249 VISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSI 308
Query: 402 CESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLP-ERLERTSVEVLDVQHN 460
+ +KL L+ N++ LP + SL N+L R+P E + T + VLDV N
Sbjct: 309 GKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGN 368
Query: 461 QLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT 508
+LL LP L + A L+ L S N +S P T +T+ E LT
Sbjct: 369 RLLHLP--LSLTALKLKALWLSDN--QSQPLLTFQTDTDYTTGEKILT 412
Score = 92.4 bits (228), Expect = 2e-18
Identities = 112/406 (27%), Positives = 165/406 (40%), Gaps = 55/406 (13%)
Query: 203 TLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTD 262
+L EL + N LR +P + L+ L N +Q LP E+ N QL L +S NE +
Sbjct: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96
Query: 263 IPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT 322
IPE + A+ SGN L ++P + LQ++T
Sbjct: 97 IPESISFCKALQVADFSGN--------PLTRLP-----------------ESFPELQNLT 131
Query: 323 QLDLRDNKLGDLDAMIFN--NIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPV 380
L + D L L I N N+ L N L L + L QL
Sbjct: 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP-------------DSLTQL----- 173
Query: 381 PNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQL 440
L +D+ N + N+PE + L+ L + NQ+ ELP + +L L N+L
Sbjct: 174 -RRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
Query: 441 ARLPERLER-TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETN 499
RLPE + TS+ L + N LLE P+ + K L L N+L LP A E+
Sbjct: 233 ERLPEEISGLTSLTDLVISQN-LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECES- 290
Query: 500 SILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGN 558
L EL LT N L +P G L L+ N+L S P ++ L + N
Sbjct: 291 --LTELVLTENQLLT--LPKSIGKLKKLSNLNADRNKLVSLP-KEIGGCCSLTVFCVRDN 345
Query: 559 KLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNE 604
+L IP + +H + N + P + ++K + LS N+
Sbjct: 346 RLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ 391
Score = 68.9 bits (167), Expect = 3e-11
Identities = 69/253 (27%), Positives = 114/253 (45%), Gaps = 14/253 (5%)
Query: 384 LSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARL 443
L + +S N ++ +P + +L LD+ N+I E+P + +L+ N L RL
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
Query: 444 PERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSIL 502
PE E ++ L V L LP N+ +L L N L LP + L
Sbjct: 121 PESFPELQNLTCLSVNDISLQSLPENI-GNLYNLASLELRENLLTYLPDSLTQLRR---L 176
Query: 503 QELYLTNN---SLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNK 559
+EL L NN +L + LL HLK L + N+L P ++ L+ L +D+S N+
Sbjct: 177 EELDLGNNEIYNLPESIGALL----HLKDLWLDGNQLSELP-QEIGNLKNLLCLDVSENR 231
Query: 560 LKAIPTTIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLPPKL 618
L+ +P I + ++ N +E P+ + +L ++ + + N L+++ L
Sbjct: 232 LERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESL 291
Query: 619 QELDLTGNPRLVL 631
EL LT N L L
Sbjct: 292 TELVLTENQLLTL 304
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/137 (24%), Positives = 60/137 (43%), Gaps = 2/137 (1%)
Query: 516 CVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHT 575
C+PL + H++ + + L P LEE+ L N+L+ +P ++
Sbjct: 4 CIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRK 63
Query: 576 VIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHK 634
+ N I+ P E+ ++ +D+S NE+ E+ + LQ D +GNP L
Sbjct: 64 LGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPES 123
Query: 635 TLELLNNIRCFKIDQPS 651
E L N+ C ++ S
Sbjct: 124 FPE-LQNLTCLSVNDIS 139
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 107 bits (266), Expect = 9e-23
Identities = 104/443 (23%), Positives = 207/443 (46%), Gaps = 62/443 (13%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
+ ++++D S CSLE +P +F + L+ L
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKT------------------------------LEEL 51
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
L N + + P + + +L +L++ N L ++PA++ + NL+ + N +Q P +
Sbjct: 52 YLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
Query: 245 ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRL 304
+N K L+ + S N + +P+ +L + +L ++ +E L ++ ++ ++LR
Sbjct: 112 KNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRE 170
Query: 305 NVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTLDICGYFL 362
N + K++ ++ L + +LDL N+ ++ ++ + ++ + N+L F+
Sbjct: 171 NQL-KMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT-------FI 222
Query: 363 KALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPA 422
S +L +Y+DVS+N +E V E + L+ L + N + +LP
Sbjct: 223 PGFIGSLKQL------------TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE 270
Query: 423 RLFCNSSLRKLLAGHNQLARLPERLERT-SVEVLDVQHNQLLELPPNLLMKADSLRFLNA 481
+ ++ L NQL LP+ + SVE LD N++ LP ++ + +LR A
Sbjct: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAA 329
Query: 482 SANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPH-LKILHMAYNRLQSFP 540
N L+ LPP S + ++L +L +N L + +P G LK+++++ NRL++ P
Sbjct: 330 DHNYLQQLPPEIGSWKNITVL---FLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLP 384
Query: 541 ASKMAKLEELEEIDLSGNKLKAI 563
S KL++L + LS N+ K +
Sbjct: 385 FS-FTKLQQLTAMWLSDNQSKPL 406
Score = 105 bits (261), Expect = 3e-22
Identities = 110/424 (25%), Positives = 186/424 (43%), Gaps = 63/424 (14%)
Query: 116 LRQVSK---VASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172
L QV K + + + L +E LP LF Q L L+L N L +LPA+
Sbjct: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT---TLPAS--- 87
Query: 173 NELQRFTKLKSLNLSNNHLGDFPLAV--CSIPTLAELNVSCNA----------------- 213
+ L+ L++S N + +FP + C + T+ E +V+ +
Sbjct: 88 --IANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145
Query: 214 ----LRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEK 269
L +PA G + LQ L N L+ LP + + QL L L NEFT++PEVLE+
Sbjct: 146 NDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205
Query: 270 LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDN 329
L+ + + M N + T + + + ++D+ N I +++ + + +++ L L N
Sbjct: 206 LSGLKEFWMDANRL-TFIPGFIGSLKQLTYLDVSKNNI-EMVEEGISTCENLQDLLLSSN 263
Query: 330 KLGDLDAMI--FNNIEVLHCERNQLVTL-DICGYFLKALYASSNELVQLDVYPVPNYLSY 386
L L I NI L + NQL+ L D G + +
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS--------------------VEE 303
Query: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPER 446
+D S N +E +P + + L HN + +LP + ++ L N+L LPE
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
Query: 447 L-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
+ + ++V+++ N+L LP + K L + S N+ + L P L +ET+S Q++
Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIP--LQKETDSETQKM 420
Query: 506 YLTN 509
LTN
Sbjct: 421 VLTN 424
Score = 69.7 bits (169), Expect = 2e-11
Identities = 84/355 (23%), Positives = 149/355 (41%), Gaps = 41/355 (11%)
Query: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428
S E V +++ L + + N++E +P+ + + L L + N + LPA +
Sbjct: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLI 92
Query: 429 SLRKLLAGHNQLARLPERLERTSV-EVLDVQHNQLLELP---------PNLLMKADSLRF 478
+LR+L N + PE ++ V +++ N + +LP L + L F
Sbjct: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
Query: 479 LNASANKLESLP------------PATLSEETNSILQELYLTNNSLTDKCVP-LLTGHPH 525
L A+ +L L P T++ T L+ L L +N T+ VP +L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ--LERLDLGSNEFTE--VPEVLEQLSG 208
Query: 526 LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEV 585
LK M NRL P + L++L +D+S N ++ + I C + ++ SN ++
Sbjct: 209 LKEFWMDANRLTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
Query: 586 FPEVM-QLPEIKCVDLSCNELSEVTLPENLPP--KLQELDLTGNPRLVLDHKTLELLNNI 642
PE + L I + + N+L + LP+++ ++ELD + N L ++ L N+
Sbjct: 268 LPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFNEVEALP-SSIGQLTNL 324
Query: 643 RCFKIDQ-------PSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNR 690
R F D P G ++ H + + + L V N DNR
Sbjct: 325 RTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Score = 50.1 bits (118), Expect = 1e-05
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 34/200 (17%)
Query: 446 RLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
R E +V LD H L ++P + +L L AN++E LP + ++ L +L
Sbjct: 18 RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQS---LHKL 74
Query: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPT 565
L +N LT + PAS +A L L E+D+S N ++ P
Sbjct: 75 SLPDNDLT------------------------TLPAS-IANLINLRELDVSKNGIQEFPE 109
Query: 566 TIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELD 622
I NC+ + V A N I P+ QL + L N+ LP N KLQ L+
Sbjct: 110 NIKNCKVLTIVEASVNPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 623 LTGNPRLVLDHKTLELLNNI 642
L N +L + KT+ L +
Sbjct: 168 LREN-QLKMLPKTMNRLTQL 186
Score = 38.9 bits (89), Expect = 0.030
Identities = 36/139 (25%), Positives = 63/139 (45%), Gaps = 8/139 (5%)
Query: 508 TNNSLTDKCVPL--LTGHPH-LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIP 564
T SL + VP L G + L ++ L+ P + LEE+ L N+++ +P
Sbjct: 3 TKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP 62
Query: 565 TTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQEL 621
+ NC+ +H + N + P + L ++ +D+S N + E PEN+ L +
Sbjct: 63 KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE--FPENIKNCKVLTIV 120
Query: 622 DLTGNPRLVLDHKTLELLN 640
+ + NP L +LLN
Sbjct: 121 EASVNPISKLPDGFSQLLN 139
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 107 bits (266), Expect = 9e-23
Identities = 104/443 (23%), Positives = 207/443 (46%), Gaps = 62/443 (13%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
+ ++++D S CSLE +P +F + L+ L
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKT------------------------------LEEL 51
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
L N + + P + + +L +L++ N L ++PA++ + NL+ + N +Q P +
Sbjct: 52 YLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
Query: 245 ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRL 304
+N K L+ + S N + +P+ +L + +L ++ +E L ++ ++ ++LR
Sbjct: 112 KNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRE 170
Query: 305 NVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTLDICGYFL 362
N + K++ ++ L + +LDL N+ ++ ++ + ++ + N+L F+
Sbjct: 171 NQL-KMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT-------FI 222
Query: 363 KALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPA 422
S +L +Y+DVS+N +E V E + L+ L + N + +LP
Sbjct: 223 PGFIGSLKQL------------TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE 270
Query: 423 RLFCNSSLRKLLAGHNQLARLPERLERT-SVEVLDVQHNQLLELPPNLLMKADSLRFLNA 481
+ ++ L NQL LP+ + SVE LD N++ LP ++ + +LR A
Sbjct: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAA 329
Query: 482 SANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPH-LKILHMAYNRLQSFP 540
N L+ LPP S + ++L +L +N L + +P G LK+++++ NRL++ P
Sbjct: 330 DHNYLQQLPPEIGSWKNITVL---FLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLP 384
Query: 541 ASKMAKLEELEEIDLSGNKLKAI 563
S KL++L + LS N+ K +
Sbjct: 385 FS-FTKLQQLTAMWLSDNQSKPL 406
Score = 105 bits (261), Expect = 3e-22
Identities = 110/424 (25%), Positives = 186/424 (43%), Gaps = 63/424 (14%)
Query: 116 LRQVSK---VASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172
L QV K + + + L +E LP LF Q L L+L N L +LPA+
Sbjct: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT---TLPAS--- 87
Query: 173 NELQRFTKLKSLNLSNNHLGDFPLAV--CSIPTLAELNVSCNA----------------- 213
+ L+ L++S N + +FP + C + T+ E +V+ +
Sbjct: 88 --IANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145
Query: 214 ----LRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEK 269
L +PA G + LQ L N L+ LP + + QL L L NEFT++PEVLE+
Sbjct: 146 NDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205
Query: 270 LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDN 329
L+ + + M N + T + + + ++D+ N I +++ + + +++ L L N
Sbjct: 206 LSGLKEFWMDANRL-TFIPGFIGSLKQLTYLDVSKNNI-EMVEEGISTCENLQDLLLSSN 263
Query: 330 KLGDLDAMI--FNNIEVLHCERNQLVTL-DICGYFLKALYASSNELVQLDVYPVPNYLSY 386
L L I NI L + NQL+ L D G + +
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS--------------------VEE 303
Query: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPER 446
+D S N +E +P + + L HN + +LP + ++ L N+L LPE
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
Query: 447 L-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
+ + ++V+++ N+L LP + K L + S N+ + L P L +ET+S Q++
Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIP--LQKETDSETQKM 420
Query: 506 YLTN 509
LTN
Sbjct: 421 VLTN 424
Score = 69.7 bits (169), Expect = 2e-11
Identities = 84/355 (23%), Positives = 149/355 (41%), Gaps = 41/355 (11%)
Query: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428
S E V +++ L + + N++E +P+ + + L L + N + LPA +
Sbjct: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLI 92
Query: 429 SLRKLLAGHNQLARLPERLERTSV-EVLDVQHNQLLELP---------PNLLMKADSLRF 478
+LR+L N + PE ++ V +++ N + +LP L + L F
Sbjct: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
Query: 479 LNASANKLESLP------------PATLSEETNSILQELYLTNNSLTDKCVP-LLTGHPH 525
L A+ +L L P T++ T L+ L L +N T+ VP +L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ--LERLDLGSNEFTE--VPEVLEQLSG 208
Query: 526 LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEV 585
LK M NRL P + L++L +D+S N ++ + I C + ++ SN ++
Sbjct: 209 LKEFWMDANRLTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
Query: 586 FPEVM-QLPEIKCVDLSCNELSEVTLPENLPP--KLQELDLTGNPRLVLDHKTLELLNNI 642
PE + L I + + N+L + LP+++ ++ELD + N L ++ L N+
Sbjct: 268 LPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFNEVEALP-SSIGQLTNL 324
Query: 643 RCFKIDQ-------PSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNR 690
R F D P G ++ H + + + L V N DNR
Sbjct: 325 RTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Score = 50.1 bits (118), Expect = 1e-05
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 34/200 (17%)
Query: 446 RLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
R E +V LD H L ++P + +L L AN++E LP + ++ L +L
Sbjct: 18 RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQS---LHKL 74
Query: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPT 565
L +N LT + PAS +A L L E+D+S N ++ P
Sbjct: 75 SLPDNDLT------------------------TLPAS-IANLINLRELDVSKNGIQEFPE 109
Query: 566 TIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELD 622
I NC+ + V A N I P+ QL + L N+ LP N KLQ L+
Sbjct: 110 NIKNCKVLTIVEASVNPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 623 LTGNPRLVLDHKTLELLNNI 642
L N +L + KT+ L +
Sbjct: 168 LREN-QLKMLPKTMNRLTQL 186
Score = 38.9 bits (89), Expect = 0.030
Identities = 36/139 (25%), Positives = 63/139 (45%), Gaps = 8/139 (5%)
Query: 508 TNNSLTDKCVPL--LTGHPH-LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIP 564
T SL + VP L G + L ++ L+ P + LEE+ L N+++ +P
Sbjct: 3 TKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP 62
Query: 565 TTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQEL 621
+ NC+ +H + N + P + L ++ +D+S N + E PEN+ L +
Sbjct: 63 KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE--FPENIKNCKVLTIV 120
Query: 622 DLTGNPRLVLDHKTLELLN 640
+ + NP L +LLN
Sbjct: 121 EASVNPISKLPDGFSQLLN 139
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 95.9 bits (237), Expect = 2e-19
Identities = 115/439 (26%), Positives = 190/439 (43%), Gaps = 48/439 (10%)
Query: 127 ISSVDLSCCSLEHLPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLN 185
IS+ DLS +L L LF+ + L L L N L P A GL L K L
Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPG-QAFSGLYSL------KILM 68
Query: 186 LSNNHLGDFPL-AVCSIPTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAE 243
L NN LG P A+ +P+L L + N + VP + + +L+ LD N L +P
Sbjct: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 128
Query: 244 -LENMKQLSYLGLSFNEFTDIPE-VLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVD 301
L N+ L + L+ N + IP+ + LT++ L + N ++ L + + +++ +D
Sbjct: 129 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD 188
Query: 302 LRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNN---IEVLHCERN--QLVTLD 356
L N +++ + L + +L +N + + F ++ +H N Q V
Sbjct: 189 LNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRS 247
Query: 357 ICGYFLKALYASSNELVQLDVYPV---PNYLSYMDVSRNRLENVPEWVCESRKLEVLDIG 413
Y K S N + + +P L + ++R + +P +C+
Sbjct: 248 AFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ---------- 297
Query: 414 HNQICELPARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKA 473
+LP LR L HNQ+ LP +E + +QHN++ E+ + +
Sbjct: 298 -----QLPR-------LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQL 345
Query: 474 DSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKIL-HMA 532
SL+ L+ S N + S+ P S T L +L LT+N LT + L G HLK+ ++A
Sbjct: 346 SSLQALDLSWNAIRSIHPEAFS--TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLA 403
Query: 533 YNRLQSFPASKMAKLEELE 551
+ Q+F KL LE
Sbjct: 404 LS--QAFSKDSFPKLRILE 420
Score = 80.9 bits (198), Expect = 7e-15
Identities = 90/390 (23%), Positives = 163/390 (41%), Gaps = 49/390 (12%)
Query: 181 LKSLNLSNNHLGDFP-LAVCSIPTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQ 238
L+ L LS NHL P A + +L L + N L +PA A+ + +LQ+ LD N +
Sbjct: 40 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 99
Query: 239 SLPAE-LENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVETLRLQALRKMPH 296
+P E + L +L L N T+IP L L A+ + ++ N + + A + +
Sbjct: 100 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 159
Query: 297 IKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVT 354
+ + L N I+ L + L ++ LDL NKL + I ++ L N +
Sbjct: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKA 219
Query: 355 LDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGH 414
+ + N L+Q ++ N + + V R+ + +P KL L +
Sbjct: 220 IPEKAFM-------GNPLLQT-IHFYDNPIQF--VGRSAFQYLP-------KLHTLSLN- 261
Query: 415 NQICELPARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKAD 474
G + P+ TS+E+L + + LP + +
Sbjct: 262 ---------------------GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLP 300
Query: 475 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYN 534
LR L S N++E LP ++ L+E+ L +N + + + L+ L +++N
Sbjct: 301 RLRVLELSHNQIEELPSLHRCQK----LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
Query: 535 RLQSFPASKMAKLEELEEIDLSGNKLKAIP 564
++S + L L ++DL+ N+L +P
Sbjct: 357 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 386
Score = 70.1 bits (170), Expect = 1e-11
Identities = 71/256 (27%), Positives = 111/256 (43%), Gaps = 33/256 (12%)
Query: 401 VCE-SRKLEVLDIGHNQICELPARLFCNSS-LRKLLAGHNQLARLPERLERT--SVEVLD 456
VC+ S + D+ N + EL LF + L +L N L+ +P + S+++L
Sbjct: 9 VCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 68
Query: 457 VQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKC 516
+Q+NQL +P L + SL+ L AN + +P + E S L+ L+L +N+LT+
Sbjct: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSF--EGLSSLRHLWLDDNALTEIP 126
Query: 517 VPLLTGHPHLK------------------------ILHMAYNRLQSFPASKMAKLEELEE 552
V L P L+ +LH+ NR+Q L LE
Sbjct: 127 VRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLET 186
Query: 553 IDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPE--VMQLPEIKCVDLSCNELSEVTL 610
+DL+ NKL+ P I R+ + H+N I+ PE M P ++ + N + V
Sbjct: 187 LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGR 246
Query: 611 PE-NLPPKLQELDLTG 625
PKL L L G
Sbjct: 247 SAFQYLPKLHTLSLNG 262
Score = 33.5 bits (75), Expect = 1.3
Identities = 36/141 (25%), Positives = 62/141 (43%), Gaps = 4/141 (2%)
Query: 490 PPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEE 549
P TL + + I+ L+ N+LT+ L L+ L ++ N L P + L
Sbjct: 4 PRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS 63
Query: 550 LEEIDLSGNKLKAIPT-TIMNCRRMHTVIAHSNCIEVFPE--VMQLPEIKCVDLSCNELS 606
L+ + L N+L IP + + ++ +N I + PE L ++ + L N L+
Sbjct: 64 LKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT 123
Query: 607 EVTLPE-NLPPKLQELDLTGN 626
E+ + N P LQ + L N
Sbjct: 124 EIPVRALNNLPALQAMTLALN 144
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 94.0 bits (232), Expect = 8e-19
Identities = 116/429 (27%), Positives = 181/429 (42%), Gaps = 91/429 (21%)
Query: 124 SQRISSVDLSCCSLEHLPANLF-YSQDLTHLNLKQNFLRQNPSLPAARGLN--------- 173
++ + SVD CSL+ +P ++ YS+ L L L N LR+ P P R LN
Sbjct: 11 NRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPK-PFFRLLNLRKLGLSDN 69
Query: 174 ELQR-------FTKLKSLNLSNNHLGDFPLAV-----------------------CSIPT 203
E+QR F +L L++S N + + P ++ + +
Sbjct: 70 EIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
Query: 204 LAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDI 263
LA L ++ +L+++P VG + NL T L N L+SLPA L + +L L L N+ +
Sbjct: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVL 189
Query: 264 PEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQ 323
P+ L L + +L + N + L E+ L+ +
Sbjct: 190 PDTLGALPNLRELWLDRNQLSAL-------------------------PPELGNLRRLVC 224
Query: 324 LDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQL-DVYPVPN 382
LD+ +N+L +L A E LV L L S N L +L D
Sbjct: 225 LDVSENRLEELPA-----------ELGGLV-------LLTDLLLSQNLLRRLPDGIGQLK 266
Query: 383 YLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLAR 442
LS + V +NRL V E + + L L + N + LP L + L L N L
Sbjct: 267 QLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEA 326
Query: 443 LPERLER-TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501
LP + ++ VL ++ N+L LPP L + L L+ + N+L+SLP A T+
Sbjct: 327 LPPEIGGCVALSVLSLRDNRLAVLPPELAHTTE-LHVLDVAGNRLQSLPFAL----THLN 381
Query: 502 LQELYLTNN 510
L+ L+L N
Sbjct: 382 LKALWLAEN 390
Score = 84.3 bits (207), Expect = 6e-16
Identities = 113/417 (27%), Positives = 177/417 (42%), Gaps = 63/417 (15%)
Query: 213 ALRSVPAAV-GVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLT 271
+L++VP + +L+ LLD N L+ LP + L LGLS NE +P +
Sbjct: 23 SLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
Query: 272 AVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKL 331
+ +L +S N + + ++++ ++ D N + +L D L+ + L L D L
Sbjct: 83 QLVELDVSRNDIPEIP-ESIKFCKALEIADFSGNPLSRL-PDGFTQLRSLAHLALNDVSL 140
Query: 332 GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSR 391
L + N LVTL++ LK+L AS + LV
Sbjct: 141 QALPGDVGNLAN--------LVTLELRENLLKSLPASLSFLV------------------ 174
Query: 392 NRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLERTS 451
KLE LD+G N + LP L +LR+L NQL+ LP L
Sbjct: 175 --------------KLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLR 220
Query: 452 VEV-LDVQHNQLLELPPNL---LMKADSLRFLNASANKLESLPPATLSEETNSILQELYL 507
V LDV N+L ELP L ++ D L S N L LP + SIL+ +
Sbjct: 221 RLVCLDVSENRLEELPAELGGLVLLTDLL----LSQNLLRRLPDGIGQLKQLSILK---V 273
Query: 508 TNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTI 567
N L + + +L L + N L + P S + KL +L +++ N L+A+P I
Sbjct: 274 DQNRLCE-VTEAIGDCENLSELILTENLLMALPRS-LGKLTKLTNLNVDRNHLEALPPEI 331
Query: 568 MNCRRMHTVIAHSNCIEVF-PEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDL 623
C + + N + V PE+ E+ +D++ N L ++LP L L+L
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRL------QSLPFALTHLNL 382
Score = 82.0 bits (201), Expect = 3e-15
Identities = 86/331 (25%), Positives = 138/331 (41%), Gaps = 50/331 (15%)
Query: 131 DLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNH 190
D S L LP + L HL L L+ P ++ L +L L N
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG--------DVGNLANLVTLELRENL 162
Query: 191 LGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQL 250
L P ++ + L +L++ N L +P +G + NL+ LD N L +LP EL N+++L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 251 SYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL 310
L +S N ++P L L + L +S N LR++P
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQN--------LLRRLP--------------- 259
Query: 311 IADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSN 370
D + L+ ++ L + N+L ++ I + CE L L + L AL S
Sbjct: 260 --DGIGQLKQLSILKVDQNRLCEVTEAIGD------CE--NLSELILTENLLMALPRSLG 309
Query: 371 ELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSL 430
+L + L+ ++V RN LE +P + L VL + N++ LP L + L
Sbjct: 310 KLTK---------LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 431 RKLLAGHNQLARLPERLERTSVEVLDVQHNQ 461
L N+L LP L +++ L + NQ
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
Score = 67.4 bits (163), Expect = 8e-11
Identities = 96/364 (26%), Positives = 146/364 (40%), Gaps = 80/364 (21%)
Query: 383 YLSYMDVSRNRLENVPEWVCE-SRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLA 441
++ +D L+ VPE + SR LE L + NQ+ ELP F +LRKL N++
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 442 RLPERLERTSVEV-LDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNS 500
RLP + V LDV N + E+P ++ +L + S N L LP +
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKF-CKALEIADFSGNPLSRLP--------DG 123
Query: 501 ILQELYLTNNSLTDKCVPLLTGH----PHLKILHMAYNRLQSFPASKMAKLEELEEIDLS 556
Q L + +L D + L G +L L + N L+S PAS ++ L +LE++DL
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSFLVKLEQLDLG 182
Query: 557 GN-----------------------KLKAIPTTIMNCRRMHTVIAHSNCIEVFPE----- 588
GN +L A+P + N RR+ + N +E P
Sbjct: 183 GNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 589 -------------------VMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRL 629
+ QL ++ + + N L EVT L EL LT N +
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 630 VLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDN 689
L ++L L + +D+ + EA + CV ALSV + DN
Sbjct: 303 ALP-RSLGKLTKLTNLNVDR---------------NHLEALPPEIGGCV-ALSVLSLRDN 345
Query: 690 REAL 693
R A+
Sbjct: 346 RLAV 349
Score = 44.7 bits (104), Expect = 5e-04
Identities = 29/114 (25%), Positives = 53/114 (46%), Gaps = 1/114 (0%)
Query: 515 KCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMH 574
KC+PL + H++ + + LQ+ P LEE+ L N+L+ +P +
Sbjct: 3 KCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLR 62
Query: 575 TVIAHSNCIE-VFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNP 627
+ N I+ + PEV ++ +D+S N++ E+ L+ D +GNP
Sbjct: 63 KLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNP 116
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 94.0 bits (232), Expect = 8e-19
Identities = 116/429 (27%), Positives = 181/429 (42%), Gaps = 91/429 (21%)
Query: 124 SQRISSVDLSCCSLEHLPANLF-YSQDLTHLNLKQNFLRQNPSLPAARGLN--------- 173
++ + SVD CSL+ +P ++ YS+ L L L N LR+ P P R LN
Sbjct: 11 NRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPK-PFFRLLNLRKLGLSDN 69
Query: 174 ELQR-------FTKLKSLNLSNNHLGDFPLAV-----------------------CSIPT 203
E+QR F +L L++S N + + P ++ + +
Sbjct: 70 EIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
Query: 204 LAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDI 263
LA L ++ +L+++P VG + NL T L N L+SLPA L + +L L L N+ +
Sbjct: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVL 189
Query: 264 PEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQ 323
P+ L L + +L + N + L E+ L+ +
Sbjct: 190 PDTLGALPNLRELWLDRNQLSAL-------------------------PPELGNLRRLVC 224
Query: 324 LDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQL-DVYPVPN 382
LD+ +N+L +L A E LV L L S N L +L D
Sbjct: 225 LDVSENRLEELPA-----------ELGGLV-------LLTDLLLSQNLLRRLPDGIGQLK 266
Query: 383 YLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLAR 442
LS + V +NRL V E + + L L + N + LP L + L L N L
Sbjct: 267 QLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEA 326
Query: 443 LPERLER-TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501
LP + ++ VL ++ N+L LPP L + L L+ + N+L+SLP A T+
Sbjct: 327 LPPEIGGCVALSVLSLRDNRLAVLPPELAHTTE-LHVLDVAGNRLQSLPFAL----THLN 381
Query: 502 LQELYLTNN 510
L+ L+L N
Sbjct: 382 LKALWLAEN 390
Score = 84.3 bits (207), Expect = 6e-16
Identities = 113/417 (27%), Positives = 177/417 (42%), Gaps = 63/417 (15%)
Query: 213 ALRSVPAAV-GVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLT 271
+L++VP + +L+ LLD N L+ LP + L LGLS NE +P +
Sbjct: 23 SLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
Query: 272 AVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKL 331
+ +L +S N + + ++++ ++ D N + +L D L+ + L L D L
Sbjct: 83 QLVELDVSRNDIPEIP-ESIKFCKALEIADFSGNPLSRL-PDGFTQLRSLAHLALNDVSL 140
Query: 332 GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSR 391
L + N LVTL++ LK+L AS + LV
Sbjct: 141 QALPGDVGNLAN--------LVTLELRENLLKSLPASLSFLV------------------ 174
Query: 392 NRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLERTS 451
KLE LD+G N + LP L +LR+L NQL+ LP L
Sbjct: 175 --------------KLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLR 220
Query: 452 VEV-LDVQHNQLLELPPNL---LMKADSLRFLNASANKLESLPPATLSEETNSILQELYL 507
V LDV N+L ELP L ++ D L S N L LP + SIL+ +
Sbjct: 221 RLVCLDVSENRLEELPAELGGLVLLTDLL----LSQNLLRRLPDGIGQLKQLSILK---V 273
Query: 508 TNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTI 567
N L + + +L L + N L + P S + KL +L +++ N L+A+P I
Sbjct: 274 DQNRLCE-VTEAIGDCENLSELILTENLLMALPRS-LGKLTKLTNLNVDRNHLEALPPEI 331
Query: 568 MNCRRMHTVIAHSNCIEVF-PEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDL 623
C + + N + V PE+ E+ +D++ N L ++LP L L+L
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRL------QSLPFALTHLNL 382
Score = 82.0 bits (201), Expect = 3e-15
Identities = 86/331 (25%), Positives = 138/331 (41%), Gaps = 50/331 (15%)
Query: 131 DLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNH 190
D S L LP + L HL L L+ P ++ L +L L N
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG--------DVGNLANLVTLELRENL 162
Query: 191 LGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQL 250
L P ++ + L +L++ N L +P +G + NL+ LD N L +LP EL N+++L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 251 SYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL 310
L +S N ++P L L + L +S N LR++P
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQN--------LLRRLP--------------- 259
Query: 311 IADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSN 370
D + L+ ++ L + N+L ++ I + CE L L + L AL S
Sbjct: 260 --DGIGQLKQLSILKVDQNRLCEVTEAIGD------CE--NLSELILTENLLMALPRSLG 309
Query: 371 ELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSL 430
+L + L+ ++V RN LE +P + L VL + N++ LP L + L
Sbjct: 310 KLTK---------LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 431 RKLLAGHNQLARLPERLERTSVEVLDVQHNQ 461
L N+L LP L +++ L + NQ
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
Score = 67.4 bits (163), Expect = 8e-11
Identities = 96/364 (26%), Positives = 146/364 (40%), Gaps = 80/364 (21%)
Query: 383 YLSYMDVSRNRLENVPEWVCE-SRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLA 441
++ +D L+ VPE + SR LE L + NQ+ ELP F +LRKL N++
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 442 RLPERLERTSVEV-LDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNS 500
RLP + V LDV N + E+P ++ +L + S N L LP +
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKF-CKALEIADFSGNPLSRLP--------DG 123
Query: 501 ILQELYLTNNSLTDKCVPLLTGH----PHLKILHMAYNRLQSFPASKMAKLEELEEIDLS 556
Q L + +L D + L G +L L + N L+S PAS ++ L +LE++DL
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSFLVKLEQLDLG 182
Query: 557 GN-----------------------KLKAIPTTIMNCRRMHTVIAHSNCIEVFPE----- 588
GN +L A+P + N RR+ + N +E P
Sbjct: 183 GNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 589 -------------------VMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRL 629
+ QL ++ + + N L EVT L EL LT N +
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 630 VLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDN 689
L ++L L + +D+ + EA + CV ALSV + DN
Sbjct: 303 ALP-RSLGKLTKLTNLNVDR---------------NHLEALPPEIGGCV-ALSVLSLRDN 345
Query: 690 REAL 693
R A+
Sbjct: 346 RLAV 349
Score = 44.7 bits (104), Expect = 5e-04
Identities = 29/114 (25%), Positives = 53/114 (46%), Gaps = 1/114 (0%)
Query: 515 KCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMH 574
KC+PL + H++ + + LQ+ P LEE+ L N+L+ +P +
Sbjct: 3 KCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLR 62
Query: 575 TVIAHSNCIE-VFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNP 627
+ N I+ + PEV ++ +D+S N++ E+ L+ D +GNP
Sbjct: 63 KLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNP 116
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 94.0 bits (232), Expect = 8e-19
Identities = 113/436 (25%), Positives = 188/436 (43%), Gaps = 48/436 (11%)
Query: 130 VDLSCCSLEHLPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSN 188
+DLS +L L LF+ + L L L N L P A GL L K L L N
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPG-QAFSGLYSL------KILMLQN 123
Query: 189 NHLGDFPL-AVCSIPTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAE-LE 245
N LG P A+ +P+L L + N + VP + + +L+ LD N L +P L
Sbjct: 124 NQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALN 183
Query: 246 NMKQLSYLGLSFNEFTDIPE-VLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRL 304
N+ L + L+ N + IP+ + LT++ L + N ++ L + + +++ +DL
Sbjct: 184 NLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNY 243
Query: 305 NVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNN---IEVLHCERN--QLVTLDICG 359
N +++ + L + +L +N + + F ++ +H N Q V
Sbjct: 244 NKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQ 302
Query: 360 YFLKALYASSNELVQLDVYPV---PNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQ 416
Y K S N + + +P L + ++R + +P +C+
Sbjct: 303 YLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ------------- 349
Query: 417 ICELPARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSL 476
+LP LR L HNQ+ LP +E + +QHN++ E+ + + SL
Sbjct: 350 --QLPR-------LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL 400
Query: 477 RFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKIL-HMAYNR 535
+ L+ S N + S+ P S T L +L LT+N LT + L G HLK+ ++A +
Sbjct: 401 QALDLSWNAIRSIHPEAFS--TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALS- 457
Query: 536 LQSFPASKMAKLEELE 551
Q+F KL LE
Sbjct: 458 -QAFSKDSFPKLRILE 472
Score = 82.4 bits (202), Expect = 2e-15
Identities = 106/443 (23%), Positives = 184/443 (41%), Gaps = 60/443 (13%)
Query: 129 SVDLSCCSLEHLPANLFYSQDLT-HLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLS 187
S D S L +P +L LT +L+L N L + GL RF L+ L LS
Sbjct: 49 SADCSELGLSAVPGDL---DPLTAYLDLSMNNLTE-----LQPGLFHHLRF--LEELRLS 98
Query: 188 NNHLGDFP-LAVCSIPTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAE-L 244
NHL P A + +L L + N L +PA A+ + +LQ+ LD N + +P
Sbjct: 99 GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSF 158
Query: 245 ENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLR 303
E + L +L L N T+IP L L A+ + ++ N + + A + + + + L
Sbjct: 159 EGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLH 218
Query: 304 LNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTLDICGYF 361
N I+ L + L ++ LDL NKL + I ++ L N + + +
Sbjct: 219 NNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFM 278
Query: 362 LKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELP 421
N L+Q ++ N + + V R+ + +P KL L +
Sbjct: 279 -------GNPLLQT-IHFYDNPIQF--VGRSAFQYLP-------KLHTLSLN-------- 313
Query: 422 ARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNA 481
G + P+ TS+E+L + + LP + + LR L
Sbjct: 314 --------------GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLEL 359
Query: 482 SANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPA 541
S N++E LP ++ L+E+ L +N + + + L+ L +++N ++S
Sbjct: 360 SHNQIEELPSLHRCQK----LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHP 415
Query: 542 SKMAKLEELEEIDLSGNKLKAIP 564
+ L L ++DL+ N+L +P
Sbjct: 416 EAFSTLHSLVKLDLTDNQLTTLP 438
Score = 71.2 bits (173), Expect = 5e-12
Identities = 69/246 (28%), Positives = 107/246 (43%), Gaps = 32/246 (13%)
Query: 410 LDIGHNQICELPARLFCNSS-LRKLLAGHNQLARLPERLERT--SVEVLDVQHNQLLELP 466
LD+ N + EL LF + L +L N L+ +P + S+++L +Q+NQL +P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 467 PNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHL 526
L + SL+ L AN + +P + E S L+ L+L +N+LT+ V L P L
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSF--EGLSSLRHLWLDDNALTEIPVRALNNLPAL 188
Query: 527 K------------------------ILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKA 562
+ +LH+ NR+Q L LE +DL+ NKL+
Sbjct: 189 QAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 248
Query: 563 IPTTIMNCRRMHTVIAHSNCIEVFPE--VMQLPEIKCVDLSCNELSEVTLPE-NLPPKLQ 619
P I R+ + H+N I+ PE M P ++ + N + V PKL
Sbjct: 249 FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLH 308
Query: 620 ELDLTG 625
L L G
Sbjct: 309 TLSLNG 314
>gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]
Length = 2527
Score = 93.6 bits (231), Expect = 1e-18
Identities = 102/379 (26%), Positives = 182/379 (48%), Gaps = 28/379 (7%)
Query: 144 LFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPT 203
+F +DL L K+ L + SL +++ + ++ + SL ++ L+ +
Sbjct: 939 IFDHEDL--LKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRD 996
Query: 204 LAELNVSCNALRSVPAAVGV-MHNLQTFLLDGNFLQSLPAEL-ENMKQLSYLGLSFNEFT 261
+ L+ C + V + +L+ L N L S P +L E +K L++L L N+FT
Sbjct: 997 IDALSQKC--------CISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFT 1048
Query: 262 DIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQH 320
P L K++ + L +S N + ++ L K P +K +L N + + + D ++
Sbjct: 1049 SFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEK 1108
Query: 321 VTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA---LYASSNELVQLD 376
+ QL L NK+ G + +++L+ +N + +L FL+A + + S + L
Sbjct: 1109 LEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEACPKVESFSARMNFLA 1166
Query: 377 VYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS-SLRKLL 434
P +P ++ + +S+N+ +PE + L LD+ N I LP S +LR+LL
Sbjct: 1167 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELL 1226
Query: 435 AGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSLRFLNASAN-KLESLP 490
HNQ++ L E+ S VE L + HN+L E+PP + ++L L+ S N +L S P
Sbjct: 1227 FSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENLTSLDVSYNLELRSFP 1285
Query: 491 --PATLSEETNSILQELYL 507
LS+ + L EL+L
Sbjct: 1286 NEMGKLSKIWDLPLDELHL 1304
Score = 57.8 bits (138), Expect = 6e-08
Identities = 62/203 (30%), Positives = 93/203 (45%), Gaps = 23/203 (11%)
Query: 440 LARLPERLERTSVEVLDV-QHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEET 498
L R L+R S + + H LL+ +L DSLR ++ S ++L+ E
Sbjct: 922 LQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASER 981
Query: 499 NSILQELYLTNNSLTD------KCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELE 551
I L L+ N L D KC ++ H HL+ L + N L SFP L+ L
Sbjct: 982 EYITS-LDLSANELRDIDALSQKCC--ISVHLEHLEKLELHQNALTSFPQQLCETLKSLT 1038
Query: 552 EIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC-----VDLSCNELS 606
+DL NK + P+ ++ + + N ++ P V+ P +KC +LS N+LS
Sbjct: 1039 HLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLKQFNLSYNQLS 1096
Query: 607 EVTLPENLP---PKLQELDLTGN 626
V PENL KL++L L GN
Sbjct: 1097 FV--PENLTDVVEKLEQLILEGN 1117
Score = 54.3 bits (129), Expect = 7e-07
Identities = 63/238 (26%), Positives = 97/238 (40%), Gaps = 31/238 (13%)
Query: 452 VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNS 511
+E L++ N L P L SL L+ +NK S P L S + L ++ N
Sbjct: 1013 LEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRND 1069
Query: 512 LTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAI------- 563
+ V T P LK +++YN+L P + +E+LE++ L GNK+ I
Sbjct: 1070 IGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLK 1129
Query: 564 PTTIMNCRRMHTVIAHSNCIEVFPEVMQL--------------PEIKCVDLSCNELSEVT 609
I+N + H N +E P+V P + + LS N+ S
Sbjct: 1130 ELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--C 1187
Query: 610 LPENL--PPKLQELDLTGNPRLVLDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 663
+PE + P L+ LD++ N L N+R F +Q S D S +WS
Sbjct: 1188 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 1245
Score = 49.3 bits (116), Expect = 2e-05
Identities = 77/304 (25%), Positives = 121/304 (39%), Gaps = 91/304 (29%)
Query: 112 YLRWLRQVSKVASQR--ISSVDLS-------------CC---SLEHL------------- 140
++R +S +AS+R I+S+DLS CC LEHL
Sbjct: 967 HMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSF 1026
Query: 141 PANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDF----P 195
P L + + LTHL+L N PS L + + + +L++S N +G P
Sbjct: 1027 PQQLCETLKSLTHLDLHSNKFTSFPSY--------LLKMSCIANLDVSRNDIGPSVVLDP 1078
Query: 196 LAVCSIPTLAELNVSCNALRSVPAAV-GVMHNLQTFLLDGNFLQSL--PAELENMK---- 248
C PTL + N+S N L VP + V+ L+ +L+GN + + P L+ +K
Sbjct: 1079 TVKC--PTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNL 1136
Query: 249 -------------------------------------QLSYLGLSFNEFTDIPEVLEKLT 271
++ L LS N+F+ IPE + L
Sbjct: 1137 SKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLP 1196
Query: 272 AVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDNK 330
+ L MS N ++ L A K +++ + N I L E +L V +L L NK
Sbjct: 1197 HLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNK 1256
Query: 331 LGDL 334
L ++
Sbjct: 1257 LKEI 1260
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 93.6 bits (231), Expect = 1e-18
Identities = 90/308 (29%), Positives = 153/308 (49%), Gaps = 21/308 (6%)
Query: 318 LQHVTQLDLRDNKLGDLDAMI---FNNIEVLHCERNQLVTLDIC----GYFLKALYASSN 370
L + L+L +N L ++ + ++ VL RN+ L G+ L L S N
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 371 ELVQL--DVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428
L L +V L +++S N+L +P + LE LD+ N++ LP L C S
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLS 181
Query: 429 SLRKLLAGHNQLARLPER-LERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLE 487
LR L HNQL P + L+ ++E LDV N+L LP + + +L+ L S +L
Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED-ISALRALKILWLSGAELG 240
Query: 488 SLPPATLSEETNSILQELYLTNNSLTDKCVPL-LTGHPHLKILHMAYNRLQSFPASKMAK 546
+LP + L+ L L NN L + +P + LK+L+++ N + FPA+ +
Sbjct: 241 TLPAGFCELAS---LESLMLDNNGL--QALPAQFSCLQRLKMLNLSSNLFEEFPAA-LLP 294
Query: 547 LEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNEL 605
L LEE+ LS N+L ++P+ I R+ T+ +N I P+ +++L ++ + L N++
Sbjct: 295 LAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQI 354
Query: 606 SEVTLPEN 613
+ LP++
Sbjct: 355 A--VLPDH 360
Score = 89.7 bits (221), Expect = 1e-17
Identities = 106/363 (29%), Positives = 170/363 (46%), Gaps = 25/363 (6%)
Query: 140 LPANLFYSQDLTHLNLKQNFLRQNPS-LPAARGLNELQRFTKLKSLNLSNNHLGDFPLAV 198
LPANL D+ LNL N L + P L +A G L+ L L N P AV
Sbjct: 58 LPANL---GDIEALNLGNNGLEEVPEGLGSALG--------SLRVLVLRRNRFARLPPAV 106
Query: 199 CSIPT-LAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLS 256
+ L EL+VS N L ++ A V + L+ L N L +LPA+L + L L +S
Sbjct: 107 AELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVS 166
Query: 257 FNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVD 316
FN +P+ L L+ + L + N + Q L+ + ++ +D+ N +R L +++
Sbjct: 167 FNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVA-LEELDVSSNRLRGL-PEDIS 224
Query: 317 FLQHVTQLDLRDNKLGDLDAMIFN--NIEVLHCERNQLVTLDI---CGYFLKALYASSNE 371
L+ + L L +LG L A ++E L + N L L C LK L SSN
Sbjct: 225 ALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284
Query: 372 LVQLDVYPVPNY-LSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSL 430
+ +P L + +SRN+L +VP + +L L + +N+I LP + + L
Sbjct: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
Query: 431 RKLLAGHNQLARLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESL 489
+L+ NQ+A LP+ + S V + ++ N L++ P + MK + ++ A +L
Sbjct: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMK--GIPYIAAYQKELAHS 402
Query: 490 PPA 492
PA
Sbjct: 403 QPA 405
Score = 67.0 bits (162), Expect = 1e-10
Identities = 47/159 (29%), Positives = 80/159 (50%), Gaps = 8/159 (5%)
Query: 123 ASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLK 182
A + +D+S L HLP +L L L++ N L P +L + L+
Sbjct: 156 ALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP--------RQLLQLVALE 207
Query: 183 SLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPA 242
L++S+N L P + ++ L L +S L ++PA + +L++ +LD N LQ+LPA
Sbjct: 208 ELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPA 267
Query: 243 ELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGN 281
+ +++L L LS N F + P L L +++L +S N
Sbjct: 268 QFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN 306
Score = 60.1 bits (144), Expect = 1e-08
Identities = 47/142 (33%), Positives = 68/142 (47%), Gaps = 8/142 (5%)
Query: 132 LSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHL 191
LS L LPA L L L N L+ +LPA + +LK LNLS+N
Sbjct: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQ---ALPA-----QFSCLQRLKMLNLSSNLF 285
Query: 192 GDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLS 251
+FP A+ + L EL +S N L SVP+ + + L T LD N ++ LP + + L
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345
Query: 252 YLGLSFNEFTDIPEVLEKLTAV 273
L L N+ +P+ +L+ V
Sbjct: 346 ELVLQGNQIAVLPDHFGQLSRV 367
Score = 45.4 bits (106), Expect = 3e-04
Identities = 41/131 (31%), Positives = 60/131 (45%), Gaps = 15/131 (11%)
Query: 127 ISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPS--LPAARGLNELQRFTKLKSL 184
+ S+ L L+ LPA Q L LNL N + P+ LP A GL EL
Sbjct: 252 LESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA-GLEELY-------- 302
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
LS N L P + + L L + N +R +P ++ + L+ +L GN + LP
Sbjct: 303 -LSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLP--- 358
Query: 245 ENMKQLSYLGL 255
++ QLS +GL
Sbjct: 359 DHFGQLSRVGL 369
Score = 39.3 bits (90), Expect = 0.023
Identities = 36/129 (27%), Positives = 57/129 (44%), Gaps = 9/129 (6%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
QR+ ++LS E PA L L L L +N L PSL + G +L +L
Sbjct: 273 QRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLG--------RLLTL 324
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
L NN + P ++ + L EL + N + +P G + + + + N L P E+
Sbjct: 325 WLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Query: 245 ENMKQLSYL 253
MK + Y+
Sbjct: 385 -CMKGIPYI 392
Score = 37.4 bits (85), Expect = 0.087
Identities = 42/169 (24%), Positives = 71/169 (42%), Gaps = 23/169 (13%)
Query: 481 ASANKLESLPPATLSEETN-SILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSF 539
A A+ LES L N ++ L L NN L + L + L++L + NR
Sbjct: 43 AGADALESPASPQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL 102
Query: 540 PASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVD 599
P + L E+D+S N+L A+ +++ R E++ ++
Sbjct: 103 PPAVAELGHHLTELDVSHNRLTALGAEVVSALR---------------------ELRKLN 141
Query: 600 LSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKID 648
LS N+L + L+ELD++ N RL +L L+ +R +D
Sbjct: 142 LSHNQLPALPAQLGALAHLEELDVSFN-RLAHLPDSLSCLSRLRTLDVD 189
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 92.8 bits (229), Expect = 2e-18
Identities = 134/526 (25%), Positives = 213/526 (40%), Gaps = 88/526 (16%)
Query: 116 LRQVSKVASQRISSVDL------SCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAA 169
L V A Q +SS+ SLE P L ++L HL+L++N LR +
Sbjct: 124 LSSVPPAAFQNLSSLGFLNLQGGQLGSLE--PQALLGLENLCHLHLERNQLR-------S 174
Query: 170 RGLNELQRFTKLKSLNLSNNHLGDFPLAVCS-IPTLAELNVSCNALRSVP-AAVGVMHNL 227
L L SL LSNN L + + +L +LN+ N+L +P AA + +L
Sbjct: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
Query: 228 QTFLLDGNFLQSL-PAELENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVET 285
+ +L GN L L PA + +L L LS N I V +L + KL + N +
Sbjct: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 294
Query: 286 LRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVL 345
+ A + ++ +DL N + L+ D L + L L N + L F ++
Sbjct: 295 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL--- 351
Query: 346 HCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESR 405
++L + + NR+ + E E
Sbjct: 352 ------------------------------------HFLEELQLGHNRIRQLAERSFEGL 375
Query: 406 -KLEVLDIGHNQICELPARLFCN-SSLRKLLAGHNQLARLPERLERT--SVEVLDVQHNQ 461
+LEVL + HNQ+ E+ A F +++ + N L LPE++ R + L ++ +
Sbjct: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435
Query: 462 LLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLT 521
L + P+ LR L N L + +L L EL LT+N LT L
Sbjct: 436 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE--LLELDLTSNQLTHLPHRLFQ 493
Query: 522 GHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSN 581
G L+ L ++ NRL PA + L+ +D+S N+L+A+P +++
Sbjct: 494 GLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLL------------- 540
Query: 582 CIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNP 627
L ++ + L N L T P+ PP L+ L L GNP
Sbjct: 541 --------APLGRLRYLSLRNNSLRTFT-PQ--PPGLERLWLEGNP 575
Score = 83.2 bits (204), Expect = 1e-15
Identities = 113/456 (24%), Positives = 183/456 (40%), Gaps = 52/456 (11%)
Query: 198 VCSIPTLA-ELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLP-AELENMKQLSYLGL 255
VCS A EL+V C++ GV Q LDGN L S+P A +N+ L +L L
Sbjct: 84 VCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNL 143
Query: 256 SFNEFTDI-PEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADE 314
+ + P+ L L + L + N + +L L P + + L N + +L
Sbjct: 144 QGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGL 203
Query: 315 VDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQ 374
+ L + L+L N L L F + L R ++ + Y AL++ EL +
Sbjct: 204 FEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL---RELVLAGNRLAYLQPALFSGLAELRE 260
Query: 375 LDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLL 434
LD+ SRN L + N +LP L+KL
Sbjct: 261 LDL------------SRNALRAIKA---------------NVFVQLPR-------LQKLY 286
Query: 435 AGHNQLARLPER--LERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPA 492
N +A + L ++ LD+ HN++ L + LR L S N + SL P
Sbjct: 287 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 346
Query: 493 TLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEE 552
T + L+EL L +N + G L++L + +N+LQ A L +
Sbjct: 347 TFKDL--HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 404
Query: 553 IDLSGNKLKAIPTTIMN-CRRMHTVIAHSNCI-----EVFPEVMQLPEIKCVDLSCNELS 606
++LSGN L+ +P + ++H++ +C+ F + L + D +
Sbjct: 405 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 464
Query: 607 EVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNI 642
E +L +L ELDLT N L H+ + L +
Sbjct: 465 EQSLWGLA--ELLELDLTSNQLTHLPHRLFQGLGKL 498
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 92.8 bits (229), Expect = 2e-18
Identities = 134/526 (25%), Positives = 213/526 (40%), Gaps = 88/526 (16%)
Query: 116 LRQVSKVASQRISSVDL------SCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAA 169
L V A Q +SS+ SLE P L ++L HL+L++N LR +
Sbjct: 86 LSSVPPAAFQNLSSLGFLNLQGGQLGSLE--PQALLGLENLCHLHLERNQLR-------S 136
Query: 170 RGLNELQRFTKLKSLNLSNNHLGDFPLAVCS-IPTLAELNVSCNALRSVP-AAVGVMHNL 227
L L SL LSNN L + + +L +LN+ N+L +P AA + +L
Sbjct: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
Query: 228 QTFLLDGNFLQSL-PAELENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVET 285
+ +L GN L L PA + +L L LS N I V +L + KL + N +
Sbjct: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 256
Query: 286 LRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVL 345
+ A + ++ +DL N + L+ D L + L L N + L F ++
Sbjct: 257 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL--- 313
Query: 346 HCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESR 405
++L + + NR+ + E E
Sbjct: 314 ------------------------------------HFLEELQLGHNRIRQLAERSFEGL 337
Query: 406 -KLEVLDIGHNQICELPARLFCN-SSLRKLLAGHNQLARLPERLERT--SVEVLDVQHNQ 461
+LEVL + HNQ+ E+ A F +++ + N L LPE++ R + L ++ +
Sbjct: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
Query: 462 LLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLT 521
L + P+ LR L N L + +L L EL LT+N LT L
Sbjct: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE--LLELDLTSNQLTHLPHRLFQ 455
Query: 522 GHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSN 581
G L+ L ++ NRL PA + L+ +D+S N+L+A+P +++
Sbjct: 456 GLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLL------------- 502
Query: 582 CIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNP 627
L ++ + L N L T P+ PP L+ L L GNP
Sbjct: 503 --------APLGRLRYLSLRNNSLRTFT-PQ--PPGLERLWLEGNP 537
Score = 83.2 bits (204), Expect = 1e-15
Identities = 113/456 (24%), Positives = 183/456 (40%), Gaps = 52/456 (11%)
Query: 198 VCSIPTLA-ELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLP-AELENMKQLSYLGL 255
VCS A EL+V C++ GV Q LDGN L S+P A +N+ L +L L
Sbjct: 46 VCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNL 105
Query: 256 SFNEFTDI-PEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADE 314
+ + P+ L L + L + N + +L L P + + L N + +L
Sbjct: 106 QGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGL 165
Query: 315 VDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQ 374
+ L + L+L N L L F + L R ++ + Y AL++ EL +
Sbjct: 166 FEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL---RELVLAGNRLAYLQPALFSGLAELRE 222
Query: 375 LDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLL 434
LD+ SRN L + N +LP L+KL
Sbjct: 223 LDL------------SRNALRAIKA---------------NVFVQLPR-------LQKLY 248
Query: 435 AGHNQLARLPER--LERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPA 492
N +A + L ++ LD+ HN++ L + LR L S N + SL P
Sbjct: 249 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 308
Query: 493 TLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEE 552
T + L+EL L +N + G L++L + +N+LQ A L +
Sbjct: 309 TFKDL--HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 366
Query: 553 IDLSGNKLKAIPTTIMN-CRRMHTVIAHSNCI-----EVFPEVMQLPEIKCVDLSCNELS 606
++LSGN L+ +P + ++H++ +C+ F + L + D +
Sbjct: 367 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 426
Query: 607 EVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNI 642
E +L +L ELDLT N L H+ + L +
Sbjct: 427 EQSLWGLA--ELLELDLTSNQLTHLPHRLFQGLGKL 460
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 92.0 bits (227), Expect = 3e-18
Identities = 107/411 (26%), Positives = 183/411 (44%), Gaps = 51/411 (12%)
Query: 127 ISSVDLSCCSLE--HLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
+ VDLS + + P N+ L L L + L P EL KL+ L
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPE--------ELAALQKLEHL 61
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRS--VPAAVGVMHNLQTFLLDGNFLQSLPA 242
++S+N+L + S+P+L + N+L++ VP + + +L L N L P
Sbjct: 62 SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
Query: 243 ELENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVD 301
ELEN K + L LS N IP ++ LT + L +S N +E+L Q +R++ H++ +
Sbjct: 122 ELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQ-MRRLVHLQTLV 180
Query: 302 LRLNVIRKLIADEVDFLQHVTQLDLRDNK--LGDLDAMI--FNNIEVLHCERNQLVTLDI 357
L N + ++ + + L LR + +L + +N+ + N L +
Sbjct: 181 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
Query: 358 CGY---FLKALYASSNELVQLDV-YPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIG 413
C Y L+ L SSN++ +L + ++ +++SRN+L ++P +C+ KL+ L +
Sbjct: 241 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 300
Query: 414 HNQI------------------------CELPARLFCN-SSLRKLLAGHNQLARLPERLE 448
N++ EL C LRKL+ N L LPE +
Sbjct: 301 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 360
Query: 449 -RTSVEVLDVQHNQLLELPPNLLMKAD---SLRFLNASANKLESLPPATLS 495
T +EVLDV+ N L +PP +A ++ F + +L PAT++
Sbjct: 361 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVA 411
Score = 90.5 bits (223), Expect = 9e-18
Identities = 102/376 (27%), Positives = 179/376 (47%), Gaps = 56/376 (14%)
Query: 340 NNIEVLHCERNQLVTLDICGYFLKALYASSNEL----VQLDVYPVPNYLSYMDVSRNRLE 395
NN+ LH E + L +L +A+ A +N L V D++ + + LS +D+S N+L
Sbjct: 66 NNLTTLHGELSSLPSL-------RAIVARANSLKNSGVPDDIFKLDD-LSVLDLSHNQLT 117
Query: 396 NVPEWVCESRKLEVLDIGHNQICELPARLFCN-SSLRKLLAGHNQLARLPERLERT---S 451
P + ++ + VL++ HN I +P +LF N + L L N+L LP ++ R
Sbjct: 118 ECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQ 177
Query: 452 VEVLD---VQHNQLLELP--------------------PNLLMKADSLRFLNASANKLES 488
VL+ + H QL +LP P L +L ++ S N L
Sbjct: 178 TLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTR 237
Query: 489 LPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLE 548
+P T L+ L L++N +T+ + + H++ L+++ N+L S P S + KL
Sbjct: 238 VPECLY---TLPSLRRLNLSSNQITELSL-CIDQWVHVETLNLSRNQLTSLP-SAICKLS 292
Query: 549 ELEEIDLSGNKLK--AIPTTIMNCRRMHTVIAHSNCIEVFPEVM-QLPEIKCVDLSCNEL 605
+L+++ L+ NKL +P+ I + +A +N +E+ PE + + P+++ + L+ N L
Sbjct: 293 KLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHL 352
Query: 606 SEVTLPENLP--PKLQELDLTGNPRLVLDHKTLELLNNIRCFKID---QPSTGDASGAPA 660
VTLPE + +++ LD+ NP LV+ K + + ID Q A +PA
Sbjct: 353 --VTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD--RAAEWYNIDFSLQNQLRLAGASPA 408
Query: 661 VWSHGYTEASGVKNKL 676
+ SG K+ +
Sbjct: 409 TVAAAAAAGSGPKDPM 424
Score = 88.6 bits (218), Expect = 3e-17
Identities = 103/398 (25%), Positives = 183/398 (45%), Gaps = 41/398 (10%)
Query: 220 AVGVMHNLQTFLLDGNFLQS--LPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLC 277
A GV+ ++ L GN + P ++ M L +L L+ +PE L L ++ L
Sbjct: 3 ATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLS 62
Query: 278 MSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL-IADEVDFLQHVTQLDLRDNKLGDLDA 336
+S N + TL + L +P ++ + R N ++ + D++ L ++ LDL N+L +
Sbjct: 63 VSHNNLTTLHGE-LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
Query: 337 MIFN--NIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRL 394
+ N N+ VL+ N + T+ L+ + +L+ Y+D+S NRL
Sbjct: 122 ELENAKNMLVLNLSHNSIDTIP------NQLFINLTDLL------------YLDLSENRL 163
Query: 395 ENVPEWVCESRKLEVLDIG-----HNQICELPARLFCNSSLRKLLAGHNQLARLPERLER 449
E++P + L+ L + H Q+ +LPA + L + + LP LE
Sbjct: 164 ESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTL--HLRSTQRTQSNLPTSLEG 221
Query: 450 TS-VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT 508
S + +D+ N L +P L SLR LN S+N++ L +L + ++ L L+
Sbjct: 222 LSNLADVDLSCNDLTRVP-ECLYTLPSLRRLNLSSNQITEL---SLCIDQWVHVETLNLS 277
Query: 509 NNSLTDKCVPLLTGHPHLKILHMAYNRLQ--SFPASKMAKLEELEEIDLSGNKLKAIPTT 566
N LT + LK L++ N+L P S + KL LEE + N L+ +P +
Sbjct: 278 RNQLTS-LPSAICKLSKLKKLYLNSNKLDFDGLP-SGIGKLTNLEEFMAANNNLELVPES 335
Query: 567 IMNCRRMHTVIAHSNCIEVFPEVMQ-LPEIKCVDLSCN 603
+ C ++ ++ + N + PE + L EI+ +D+ N
Sbjct: 336 LCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
Score = 80.5 bits (197), Expect = 9e-15
Identities = 75/273 (27%), Positives = 123/273 (45%), Gaps = 35/273 (12%)
Query: 384 LSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLA-------- 435
L ++ ++R L +PE + +KLE L + HN + L L SLR ++A
Sbjct: 35 LRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNS 94
Query: 436 -----------------GHNQLARLPERLERT-SVEVLDVQHNQLLELPPNLLMKADSLR 477
HNQL P LE ++ VL++ HN + +P L + L
Sbjct: 95 GVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLL 154
Query: 478 FLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHM-AYNRL 536
+L+ S N+LESLPP LQ L L N L + L L+ LH+ + R
Sbjct: 155 YLDLSENRLESLPP---QMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRT 211
Query: 537 QSFPASKMAKLEELEEIDLSGNKLKAIPT---TIMNCRRMHTVIAHSNCIEVFPEVMQLP 593
QS + + L L ++DLS N L +P T+ + RR++ ++ + E+ + Q
Sbjct: 212 QSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLN--LSSNQITELSLCIDQWV 269
Query: 594 EIKCVDLSCNELSEVTLPENLPPKLQELDLTGN 626
++ ++LS N+L+ + KL++L L N
Sbjct: 270 HVETLNLSRNQLTSLPSAICKLSKLKKLYLNSN 302
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 90.9 bits (224), Expect = 7e-18
Identities = 97/375 (25%), Positives = 167/375 (44%), Gaps = 68/375 (18%)
Query: 116 LRQVSKVA---SQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172
L+QV K + + + L +E LP LF Q L L++ N L P+ A+
Sbjct: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIAS--- 90
Query: 173 NELQRFTKLKSLNLSNNHLGDFP--LAVCSIPTLAELNVSCNA----------------- 213
LK L++S N + +FP + C T+ E +V+ +
Sbjct: 91 -----LVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYL 145
Query: 214 ----LRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEK 269
L +PA G + L+ L N L++LP + + QL L L NEF ++PEVL++
Sbjct: 146 NDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205
Query: 270 LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL------------------- 310
+ + +L M N ++ L ++ K+ + ++D+ N I +
Sbjct: 206 IQNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM 264
Query: 311 ---IADEVDFLQHVTQLDLRDNKLGDLDAMIFNN--IEVLHCERNQLVTL-DICGYF--L 362
+ D + L+ +T L + DN+L L I N +E C N+L +L GY L
Sbjct: 265 LQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSL 324
Query: 363 KALYASSNELVQL--DVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420
+ L N L +L ++ N ++ M + N+LE +PE + + +KL VL++ N++ L
Sbjct: 325 RTLAVDENFLPELPREIGSCKN-VTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNL 383
Query: 421 PARLFCNSSLRKLLA 435
P F + L++L A
Sbjct: 384 P---FSFTKLKELAA 395
Score = 90.1 bits (222), Expect = 1e-17
Identities = 111/425 (26%), Positives = 195/425 (45%), Gaps = 62/425 (14%)
Query: 204 LAELNVSCNALRSVPAAV-GVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTD 262
++ L+ S +L+ VP V L+ LD N ++ LP +L N + L L + N+ ++
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 263 IPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT 322
+P + L + +L +S N V+ + ++ + ++ +N I KL D L ++T
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFP-ENIKCCKCLTIIEASVNPISKL-PDGFTQLLNLT 141
Query: 323 QLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPN 382
QL L D FL+ L A+ LV+L +
Sbjct: 142 QLYLNDA-------------------------------FLEFLPANFGRLVKLRI----- 165
Query: 383 YLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLAR 442
+++ N L+ +P+ + + +LE LD+G+N+ ELP L +LR+L +N L
Sbjct: 166 ----LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQV 221
Query: 443 LPERLERTSVEV-LDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501
LP + + + V LD+ N+ +E + ++L L S+N L+ LP S
Sbjct: 222 LPGSIGKLKMLVYLDMSKNR-IETVDMDISGCEALEDLLLSSNMLQQLPD---SIGLLKK 277
Query: 502 LQELYLTNNSLTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL 560
L L + +N LT +P G+ L+ + N L+S P S + L L + + N L
Sbjct: 278 LTTLKVDDNQLT--MLPNTIGNLSLLEEFDCSCNELESLP-STIGYLHSLRTLAVDENFL 334
Query: 561 KAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP---P 616
+P I +C+ + + SN +E P E+ Q+ +++ ++LS N L +NLP
Sbjct: 335 PELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRL------KNLPFSFT 388
Query: 617 KLQEL 621
KL+EL
Sbjct: 389 KLKEL 393
Score = 68.9 bits (167), Expect = 3e-11
Identities = 71/286 (24%), Positives = 123/286 (43%), Gaps = 40/286 (13%)
Query: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428
S + V +V+ L + + N++E ELP +LF
Sbjct: 33 SLQQVPKEVFNFERTLEELYLDANQIE-----------------------ELPKQLFNCQ 69
Query: 429 SLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLE 487
+LRKL N L+ LP + +++ LD+ N + E P N+ L + AS N +
Sbjct: 70 ALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKC-CKCLTIIEASVNPIS 128
Query: 488 SLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH----PHLKILHMAYNRLQSFPASK 543
LP + Q L LT L D + L + L+IL + N L++ P S
Sbjct: 129 KLP--------DGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS- 179
Query: 544 MAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSC 602
M KL +LE +DL N+ +P + + + + +N ++V P + +L + +D+S
Sbjct: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK 239
Query: 603 NELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKID 648
N + V + + L++L L+ N L ++ LL + K+D
Sbjct: 240 NRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVD 284
Score = 50.1 bits (118), Expect = 1e-05
Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 54/176 (30%)
Query: 130 VDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNN 189
+D+S +E + ++ + L L L N L+Q LP + GL KL +L + +N
Sbjct: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQ---LPDSIGL-----LKKLTTLKVDDN 286
Query: 190 HLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELEN--- 246
L P + ++ L E + SCN L S+P+ +G +H+L+T +D NFL LP E+ +
Sbjct: 287 QLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKN 346
Query: 247 -------------------------------------------MKQLSYLGLSFNE 259
+K+L+ L LS N+
Sbjct: 347 VTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
Score = 42.7 bits (99), Expect = 0.002
Identities = 32/109 (29%), Positives = 48/109 (44%), Gaps = 21/109 (19%)
Query: 127 ISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL-------------- 172
+ D SC LE LP+ + Y L L + +NFL P LP G
Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFL---PELPREIGSCKNVTVMSLRSNKL 357
Query: 173 ----NELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSV 217
E+ + KL+ LNLS+N L + P + + LA L +S N +++
Sbjct: 358 EFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 38.5 bits (88), Expect = 0.039
Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 5/118 (4%)
Query: 526 LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEV 585
+ +L ++ LQ P LEE+ L N+++ +P + NC+ + + N +
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 586 FP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELDLTGNPRLVLDHKTLELLN 640
P + L +K +D+S N + E PEN+ L ++ + NP L +LLN
Sbjct: 84 LPTTIASLVNLKELDISKNGVQE--FPENIKCCKCLTIIEASVNPISKLPDGFTQLLN 139
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 88.2 bits (217), Expect = 4e-17
Identities = 119/453 (26%), Positives = 199/453 (43%), Gaps = 56/453 (12%)
Query: 130 VDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQ---NPSLPAARGLNELQRFTKLKSLNL 186
VD S L LP+NL S ++L+L N + Q NP LP+ R L EL+ L
Sbjct: 50 VDCSDLGLSELPSNL--SVFTSYLDLSMNNISQLLPNP-LPSLRFLEELR---------L 97
Query: 187 SNNHLGDFPL-AVCSIPTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAE- 243
+ N L P A + +L L + N LR VP A+ + +LQ+ LD N + +P
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSC 157
Query: 244 LENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDL 302
+ L +L L N T+IP + L+A+ + ++ N + + A + + + L
Sbjct: 158 FSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217
Query: 303 RLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTLDICGY 360
N I L D L + LDL N L + I +N++ L N + ++
Sbjct: 218 HNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP---- 273
Query: 361 FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEW----------------VCES 404
+ + + L+ + Y P V R+ +++PE + +
Sbjct: 274 --EKAFVGNPSLITIHFYDNPIQF----VGRSAFQHLPELRTLTLNGASQITEFPDLTGT 327
Query: 405 RKLEVLDIGHNQICELPARLFCNS--SLRKLLAGHNQLARLPERLERTSVEVLDVQHNQL 462
LE L + QI LP + CN +L+ L +N L LP ++ +D++HN++
Sbjct: 328 ANLESLTLTGAQISSLPQTV-CNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 386
Query: 463 LELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTG 522
E+ + + SLR LN + NK+ + P S T L +L L++N L+ + L G
Sbjct: 387 YEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFS--TLPSLIKLDLSSNLLSSFPITGLHG 444
Query: 523 HPHLKILHMAYNRLQSFPASKMAKLEELEEIDL 555
HLK+ + LQS +S+ EL+ I++
Sbjct: 445 LTHLKL--TGNHALQSLISSE--NFPELKVIEM 473
Score = 70.5 bits (171), Expect = 9e-12
Identities = 109/501 (21%), Positives = 210/501 (41%), Gaps = 73/501 (14%)
Query: 237 LQSLPAELENMKQLSYLGLSFNEFTDI-PEVLEKLTAVDKLCMSGNCVETLRLQALRKMP 295
L LP+ L SYL LS N + + P L L +++L ++GN + + A +
Sbjct: 57 LSELPSNLSVFT--SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLY 114
Query: 296 HIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTL 355
+K + L+ N +R + + + L+ + L L N + + F+ +
Sbjct: 115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL------------- 161
Query: 356 DICGYFLKALYASSNELVQLDVYPVPNY--LSYMDVSRNRLENVPEWVCES-RKLEVLDI 412
+ L+ L+ N L ++ V + L M ++ N++ ++P++ + L VL +
Sbjct: 162 ----HSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217
Query: 413 GHNQICELPARLFCN-SSLRKLLAGHNQLARLPERLERTS-VEVLDVQHNQLLELPPNLL 470
+N+I L + F SL L +N L P + S ++ L N + +P
Sbjct: 218 HNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAF 277
Query: 471 MKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILH 530
+ SL ++ N ++ + + L+ L L S + P LTG +L+ L
Sbjct: 278 VGNPSLITIHFYDNPIQFVGRSAFQHLPE--LRTLTLNGASQITE-FPDLTGTANLESLT 334
Query: 531 MAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTV-IAHSNCIEVFPEV 589
+ ++ S P + +L L+ +DLS N L+ +P+ + C+++ + + H+ E+ +
Sbjct: 335 LTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSV-CQKLQKIDLRHNEIYEIKVDT 393
Query: 590 -MQLPEIKCVDLSCNELSEVTLPE--NLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFK 646
QL ++ ++L+ N+++ + P + P L +LDL+ N LL++
Sbjct: 394 FQQLLSLRSLNLAWNKIA-IIHPNAFSTLPSLIKLDLSSN-----------LLSSF---- 437
Query: 647 IDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVP 706
P TG HG T N + +S NF + + +E+P
Sbjct: 438 ---PITG---------LHGLTHLKLTGNHALQSLISSENFPELKV-----------IEMP 474
Query: 707 YLLQCTMSDILAEELQKTKNE 727
Y QC + E K N+
Sbjct: 475 YAYQCCAFGV-CENAYKISNQ 494
Score = 53.1 bits (126), Expect = 2e-06
Identities = 49/220 (22%), Positives = 104/220 (47%), Gaps = 14/220 (6%)
Query: 127 ISSVDLSCCSLEHLPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLN 185
+ ++ L+ + H+P F + L L+L N + + G L++L+
Sbjct: 188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIH-------SLGKKCFDGLHSLETLD 240
Query: 186 LSNNHLGDFPLAVCSIPTLAELNVSCNALRSVP--AAVGVMHNLQTFLLDGNFLQSLPAE 243
L+ N+L +FP A+ ++ L EL N +RS+P A VG + D +
Sbjct: 241 LNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA 300
Query: 244 LENMKQLSYLGLS-FNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDL 302
+++ +L L L+ ++ T+ P+ L ++ L ++G + +L ++P+++ +DL
Sbjct: 301 FQHLPELRTLTLNGASQITEFPD-LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDL 359
Query: 303 RLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNI 342
N++ L + V Q + ++DLR N++ ++ F +
Sbjct: 360 SYNLLEDLPSFSV--CQKLQKIDLRHNEIYEIKVDTFQQL 397
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 87.4 bits (215), Expect = 7e-17
Identities = 95/397 (23%), Positives = 166/397 (41%), Gaps = 66/397 (16%)
Query: 191 LGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQ- 249
L P V I L L + +PA + + NLQ L ++ A L +K+
Sbjct: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
Query: 250 LSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLR----LQALRKMPHIKHVDLRLN 305
L L + F++ ++P + L +++L + G+ + L++LR + +K + ++ N
Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
Query: 306 VIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKAL 365
V K+ VD H+ ++ C N L + K
Sbjct: 553 V-SKIPQAVVDVSSHLQKM----------------------CIHNDGTKLVMLNNLKKMT 589
Query: 366 YASSNELVQLDVYPVPNY------LSYMDVSRNRLENVPEWVC--ESRKLEVLDIGHNQI 417
+ ELV D+ +P+ L +D+ N L+++ E V RKL VL + HN I
Sbjct: 590 NLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSI 649
Query: 418 CELPARLFCNSSLRKLLAGHNQLARLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 476
+P + +SL +L HN++ LP L + + LD+ +N + +PP + + SL
Sbjct: 650 TYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGV-LQSL 708
Query: 477 RFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRL 536
++ + + NK+ESLP ELY LK L + N L
Sbjct: 709 QYFSITCNKVESLP------------DELYFCKK---------------LKTLKIGKNSL 741
Query: 537 QSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRM 573
S + K+ L L +D+ GN + +P + +CR +
Sbjct: 742 -SVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRAL 777
Score = 70.9 bits (172), Expect = 7e-12
Identities = 85/370 (22%), Positives = 167/370 (45%), Gaps = 28/370 (7%)
Query: 116 LRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNEL 175
LRQ K+ + + ++L L LP +F +L L L+ + +N +PA +
Sbjct: 414 LRQ--KLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLE---IIKNVMIPAT-----I 463
Query: 176 QRFTKLKSLNLSNNHLGDFPLAVCSIP-TLAELNVSCNALRSVPAAVGVMHNLQTFLLDG 234
+ L+ L+L + A+ + L L+V + +R +P + + NL+ L G
Sbjct: 464 AQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVG 523
Query: 235 NFLQSLPAE-----LENMKQLSYLGLSFNEFTDIPE-VLEKLTAVDKLCMSGNCVETLRL 288
+ + L ++K L L + N + IP+ V++ + + K+C+ + + + L
Sbjct: 524 SLSHDISRNVTLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVML 582
Query: 289 QALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI----FNNIEV 344
L+KM ++ ++L ++ + I V L + +LDL++N L ++ ++ + V
Sbjct: 583 NNLKKMTNLTELEL-VHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTV 641
Query: 345 LHCERNQLVTLDICGYFLKALYASSNELVQLDVYP----VPNYLSYMDVSRNRLENVPEW 400
L N + + L +L S +++V P + N + Y+D+S N + +P
Sbjct: 642 LKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPE 701
Query: 401 VCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQH 459
+ + L+ I N++ LP L+ L+ L G N L+ L ++ + LDV+
Sbjct: 702 IGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKG 761
Query: 460 NQLLELPPNL 469
N LPP L
Sbjct: 762 NHFEILPPEL 771
Score = 68.9 bits (167), Expect = 3e-11
Identities = 69/237 (29%), Positives = 106/237 (44%), Gaps = 40/237 (16%)
Query: 172 LNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFL 231
LN L++ T L L L + L P AV S+ +L EL++ N L+S+ V H
Sbjct: 582 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQH------ 635
Query: 232 LDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQAL 291
+++L+ L L N T IPE ++KLT++++L S N +E L L
Sbjct: 636 ---------------LRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSH-L 679
Query: 292 RKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQ 351
I+++DL N IR I E+ LQ + + NK+ L E+ C++
Sbjct: 680 FLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVESLPD------ELYFCKK-- 730
Query: 352 LVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLE 408
L TL I L L L+ +LSY+DV N E +P + + R L+
Sbjct: 731 LKTLKIGKNSLSVLSPKIGNLL---------FLSYLDVKGNHFEILPPELGDCRALK 778
Score = 56.6 bits (135), Expect = 1e-07
Identities = 65/268 (24%), Positives = 124/268 (46%), Gaps = 20/268 (7%)
Query: 384 LSYMDVSRNRLENVPEWVCESRKLEVL----DIGHNQICELPARLFCNSSLRKLLAGHNQ 439
L + V + + +P W+ R LE L + H+ + + K+L+ +
Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
Query: 440 LARLPERLERTSVEVLDVQ-HNQLLELPP-NLLMKADSLRFLNASANKLESLPPATLSEE 497
++++P+ + S + + HN +L N L K +L L LE +P A S
Sbjct: 553 VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLL 612
Query: 498 TNSILQELYLTNNSLTDKCVPLLTGHPHLK---ILHMAYNRLQSFPASKMAKLEELEEID 554
+ LQEL L N+L K + + HL+ +L + +N + P + KL LE +
Sbjct: 613 S---LQELDLKENNL--KSIEEIVSFQHLRKLTVLKLWHNSITYIP-EHIKKLTSLERLS 666
Query: 555 LSGNKLKAIPTTIMNCRRMHTV-IAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPEN 613
S NK++ +P+ + C ++ + +++++ + PE+ L ++ ++CN++ +LP+
Sbjct: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVE--SLPDE 724
Query: 614 L--PPKLQELDLTGNPRLVLDHKTLELL 639
L KL+ L + N VL K LL
Sbjct: 725 LYFCKKLKTLKIGKNSLSVLSPKIGNLL 752
Score = 47.8 bits (112), Expect = 6e-05
Identities = 42/189 (22%), Positives = 80/189 (42%), Gaps = 40/189 (21%)
Query: 127 ISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNEL----------- 175
++ ++L C LE +P +F L L+LK+N L+ + + + L +L
Sbjct: 591 LTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650
Query: 176 ------QRFTKLKSLNLSNNHLGDFP--LAVCS---------------------IPTLAE 206
++ T L+ L+ S+N + P L +C+ + +L
Sbjct: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQY 710
Query: 207 LNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEV 266
+++CN + S+P + L+T + N L L ++ N+ LSYL + N F +P
Sbjct: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770
Query: 267 LEKLTAVDK 275
L A+ +
Sbjct: 771 LGDCRALKR 779
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 86.7 bits (213), Expect = 1e-16
Identities = 127/482 (26%), Positives = 201/482 (41%), Gaps = 70/482 (14%)
Query: 130 VDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNN 189
VD L P +L + HL+L+ N L + EL R +L++LNL NN
Sbjct: 128 VDCGGIDLREFPGDL--PEHTNHLSLQNNQLEKIYP-------EELSRLHRLETLNLQNN 178
Query: 190 HLGDFPLAVCSIPTLAELNVSC--------------NALRSVPAAV-----------GVM 224
L L + L LN NAL SV A G
Sbjct: 179 RLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQK 238
Query: 225 HNLQTFLLDGNFL--QSLPAELEN-MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGN 281
NL++ L N L LP + N + L LS N +P+ L A+ KL + N
Sbjct: 239 PNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLP--PALYKLHLKNN 296
Query: 282 CVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDF--LQHVTQLDLRDNKLGDLDAMIF 339
+E + A ++ ++ + L+ N + D F L + LDL N L + A +
Sbjct: 297 KLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLP 356
Query: 340 NNIEVLHCERNQLVTLDICGY----FLKALYASSNELVQLDVYPVP----NYLSYMDVSR 391
++ +LH E+N + ++D L+ L SN+L + ++P+ L + +
Sbjct: 357 RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYN 416
Query: 392 NRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS-SLRKLLAGHNQLARLPERLERT 450
N LE VP + R++ L I HNQI + F + L +L +N++ ++ R
Sbjct: 417 NALERVPSGL--PRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRIT--SPQVHRD 472
Query: 451 S------VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQE 504
+ + LD+ N+L LPP L ++ L N+L +L L L+E
Sbjct: 473 AFRKLRLLRSLDLSGNRLHTLPPGL---PRNVHVLKVKRNELAALARGALVGMAQ--LRE 527
Query: 505 LYLTNNSLTDKCV--PLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKA 562
LYLT+N L + + HL++L +A N+L P E LE + L NK+ A
Sbjct: 528 LYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLP---ESLEYLYLQNNKISA 584
Query: 563 IP 564
+P
Sbjct: 585 VP 586
Score = 84.3 bits (207), Expect = 6e-16
Identities = 126/490 (25%), Positives = 203/490 (41%), Gaps = 76/490 (15%)
Query: 136 SLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNE--LQRFTKLKSLNLSNNHLGD 193
SL++ Y ++L+ L+ + QN L +RGL E + T L L L+NN L
Sbjct: 150 SLQNNQLEKIYPEELSRLHRLETLNLQNNRL-TSRGLPEKAFEHLTNLNYLYLANNKL-- 206
Query: 194 FPLAVCSIPT-LAELNVSCNALRSVPAAV-GVMHNLQTFLLDGNFLQS--LPAELEN-MK 248
LA +P L ++ + N L + G NL++ L N L LP + N
Sbjct: 207 -TLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
Query: 249 QLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIR 308
+ L LS N +P+ L A+ KL + N +E + A ++ ++ + L+ N +
Sbjct: 266 NVEVLILSSNFLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLT 323
Query: 309 KLIADEVDF--LQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYF----L 362
D F L + LDL N L + A + ++ +LH E+N + ++D L
Sbjct: 324 DEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSL 383
Query: 363 KALYASSNELVQLDVYPVP----NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQIC 418
+ L SN+L + ++P+ L + + N LE VP + R++ L I HNQI
Sbjct: 384 EYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGL--PRRVRTLMILHNQIT 441
Query: 419 ELPARLFCNSS---------------------------LRKLLAGHNQLARLPERLERTS 451
+ F + LR L N+L LP L R +
Sbjct: 442 GIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPR-N 500
Query: 452 VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLES--LPPAT---------------- 493
V VL V+ N+L L L+ LR L ++N+L S L P
Sbjct: 501 VHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQ 560
Query: 494 ---LSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQ--SFPASKMAKLE 548
+ E L+ LYL NN ++ P+LK + + +N+L S S +L+
Sbjct: 561 LTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLK 620
Query: 549 ELEEIDLSGN 558
L+ +D+ GN
Sbjct: 621 HLQVLDIEGN 630
Score = 73.2 bits (178), Expect = 1e-12
Identities = 96/346 (27%), Positives = 160/346 (46%), Gaps = 33/346 (9%)
Query: 115 WLRQVSKVASQRISSVDLSCCSLEHLPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLN 173
+LR V K + + L LE +P F L L L+ N+L GL+
Sbjct: 276 FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDE-------GLD 328
Query: 174 ELQRFTKLKSL---NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGV-MHNLQT 229
+ F KL SL +LS+N+L P + +L L++ NA+RSV A V + +L+
Sbjct: 329 N-ETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDANVLTPIRSLEY 385
Query: 230 FLLDGNFLQSL---PAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETL 286
LL N L+ P + +K+L + L N +P L + V L + N + +
Sbjct: 386 LLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGI 443
Query: 287 RLQALRKMPHIKHVDLRLNVIR--KLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEV 344
+ ++ ++L N I ++ D L+ + LDL N+L L + N+ V
Sbjct: 444 GREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHV 503
Query: 345 LHCERNQLVTL---DICGYF-LKALYASSNELVQLDVYPVP----NYLSYMDVSRNRLEN 396
L +RN+L L + G L+ LY +SN L + P +L +D++ N+L
Sbjct: 504 LKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTE 563
Query: 397 VPEWVCESRKLEVLDIGHNQICELPARLFCNS-SLRKLLAGHNQLA 441
+PE + ES LE L + +N+I +PA F ++ +L+ + N+LA
Sbjct: 564 IPEGLPES--LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA 607
Score = 41.6 bits (96), Expect = 0.005
Identities = 51/176 (28%), Positives = 70/176 (39%), Gaps = 32/176 (18%)
Query: 455 LDVQHNQLLELPPNLLMKADSLRFLNASANKLES--LPPATLSEETNSILQELYLTNNSL 512
L +Q+NQL ++ P L + L LN N+L S LP TN L LYL NN L
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTN--LNYLYLANNKL 206
Query: 513 TDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL--KAIPTTIMNC 570
T P + + + A N L + L + L NKL +P + N
Sbjct: 207 T--LAPRFLPNALISV-DFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN- 262
Query: 571 RRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGN 626
SN ++ + LS N L V P++LPP L +L L N
Sbjct: 263 -------GSSN-------------VEVLILSSNFLRHV--PKHLPPALYKLHLKNN 296
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 85.1 bits (209), Expect = 4e-16
Identities = 117/455 (25%), Positives = 193/455 (42%), Gaps = 61/455 (13%)
Query: 126 RISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLN 185
R+ +VD L P N+ ++ HL+L+ N L++ P NEL R + L++LN
Sbjct: 52 RVDTVDCDGLDLRVFPDNI--TRAAQHLSLQNNQLQELP-------YNELSRLSGLRTLN 102
Query: 186 LSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVM-HNLQTFLLDGN-FLQSLPAE 243
L NN + L + +L +L C A + A + +L+ L N ++ P
Sbjct: 103 LHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLT 162
Query: 244 LENMKQLSYLGLSFNEFTDI---PEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHV 300
L + L N+ ++ P+ A+ L +S N + L P ++ +
Sbjct: 163 FGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERL 219
Query: 301 DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGD--LDAMIF---NNIEVLHCERNQLVTL 355
L+ N+I K+ + + +L L+ N+L D LDA F +++E L NQL T+
Sbjct: 220 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV 279
Query: 356 DICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENV-PEWVCESRKLEVLDIGH 414
+P L+ + + RNR+ V + +R L L + H
Sbjct: 280 PA---------------------GLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQH 318
Query: 415 NQI--CELPARLFCNSSLRKLLAGH------NQLARLPERLERTSVEVLDVQHNQLLELP 466
NQ+ LPA +LR L H N L R+P L R + L + HN + L
Sbjct: 319 NQLGSSGLPA-----GALRPLRGLHTLHLYGNGLDRVPPALPR-RLRALVLPHNHVAALG 372
Query: 467 PNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHL 526
L+ L LN + N+L S + L+ L L N LT + L TG L
Sbjct: 373 ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---L 429
Query: 527 KILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLK 561
+ L + N+L+ +A L++L E+ L+ N+L+
Sbjct: 430 RTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
Score = 67.4 bits (163), Expect = 8e-11
Identities = 59/186 (31%), Positives = 87/186 (46%), Gaps = 34/186 (18%)
Query: 384 LSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL-PARLFCNSSLRKLLAGHNQL-- 440
L ++ V+ N+L P+++ R L V D+ NQ+ E+ P +LR + +NQL
Sbjct: 124 LQHLCVAHNKLSVAPQFL--PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN 181
Query: 441 ARLPERLERTS--VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEET 498
A LP R S + L + +NQL LPP+L SL L+ N + +P LS +T
Sbjct: 182 AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQT 238
Query: 499 NSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGN 558
L+ELYL +N LTD A+ +KL LE +DLS N
Sbjct: 239 Q--LRELYLQHNQLTDS----------------------GLDATTFSKLHSLEYLDLSHN 274
Query: 559 KLKAIP 564
+L +P
Sbjct: 275 QLTTVP 280
Score = 49.3 bits (116), Expect = 2e-05
Identities = 59/202 (29%), Positives = 85/202 (42%), Gaps = 40/202 (19%)
Query: 444 PERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQ 503
P+ + R + + L +Q+NQL ELP N L + LR LN N + S
Sbjct: 67 PDNITRAA-QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISS--------------- 110
Query: 504 ELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAI 563
L D+ LT HL + H N+L P L DL+ N++ I
Sbjct: 111 ------EGLPDEAFESLTQLQHLCVAH---NKLSVAP---QFLPRSLRVADLAANQVMEI 158
Query: 564 -PTTIMNCRRMHTVIAHSNCIE---VFPEVMQLPE-IKCVDLSCNELSEVTLPENLPPKL 618
P T + +V H+N + + P+ + E I + LS N+LS LP +LPP L
Sbjct: 159 FPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLS--YLPPSLPPSL 216
Query: 619 QELDLTGN-----PRLVLDHKT 635
+ L L N PR L +T
Sbjct: 217 ERLHLQNNLISKVPRGALSRQT 238
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 85.1 bits (209), Expect = 4e-16
Identities = 117/455 (25%), Positives = 193/455 (42%), Gaps = 61/455 (13%)
Query: 126 RISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLN 185
R+ +VD L P N+ ++ HL+L+ N L++ P NEL R + L++LN
Sbjct: 54 RVDTVDCDGLDLRVFPDNI--TRAAQHLSLQNNQLQELP-------YNELSRLSGLRTLN 104
Query: 186 LSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVM-HNLQTFLLDGN-FLQSLPAE 243
L NN + L + +L +L C A + A + +L+ L N ++ P
Sbjct: 105 LHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLT 164
Query: 244 LENMKQLSYLGLSFNEFTDI---PEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHV 300
L + L N+ ++ P+ A+ L +S N + L P ++ +
Sbjct: 165 FGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERL 221
Query: 301 DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGD--LDAMIF---NNIEVLHCERNQLVTL 355
L+ N+I K+ + + +L L+ N+L D LDA F +++E L NQL T+
Sbjct: 222 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV 281
Query: 356 DICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENV-PEWVCESRKLEVLDIGH 414
+P L+ + + RNR+ V + +R L L + H
Sbjct: 282 PA---------------------GLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQH 320
Query: 415 NQI--CELPARLFCNSSLRKLLAGH------NQLARLPERLERTSVEVLDVQHNQLLELP 466
NQ+ LPA +LR L H N L R+P L R + L + HN + L
Sbjct: 321 NQLGSSGLPA-----GALRPLRGLHTLHLYGNGLDRVPPALPR-RLRALVLPHNHVAALG 374
Query: 467 PNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHL 526
L+ L LN + N+L S + L+ L L N LT + L TG L
Sbjct: 375 ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---L 431
Query: 527 KILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLK 561
+ L + N+L+ +A L++L E+ L+ N+L+
Sbjct: 432 RTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 466
Score = 67.4 bits (163), Expect = 8e-11
Identities = 59/186 (31%), Positives = 87/186 (46%), Gaps = 34/186 (18%)
Query: 384 LSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL-PARLFCNSSLRKLLAGHNQL-- 440
L ++ V+ N+L P+++ R L V D+ NQ+ E+ P +LR + +NQL
Sbjct: 126 LQHLCVAHNKLSVAPQFL--PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN 183
Query: 441 ARLPERLERTS--VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEET 498
A LP R S + L + +NQL LPP+L SL L+ N + +P LS +T
Sbjct: 184 AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQT 240
Query: 499 NSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGN 558
L+ELYL +N LTD A+ +KL LE +DLS N
Sbjct: 241 Q--LRELYLQHNQLTDS----------------------GLDATTFSKLHSLEYLDLSHN 276
Query: 559 KLKAIP 564
+L +P
Sbjct: 277 QLTTVP 282
Score = 49.3 bits (116), Expect = 2e-05
Identities = 59/202 (29%), Positives = 85/202 (42%), Gaps = 40/202 (19%)
Query: 444 PERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQ 503
P+ + R + + L +Q+NQL ELP N L + LR LN N + S
Sbjct: 69 PDNITRAA-QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISS--------------- 112
Query: 504 ELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAI 563
L D+ LT HL + H N+L P L DL+ N++ I
Sbjct: 113 ------EGLPDEAFESLTQLQHLCVAH---NKLSVAP---QFLPRSLRVADLAANQVMEI 160
Query: 564 -PTTIMNCRRMHTVIAHSNCIE---VFPEVMQLPE-IKCVDLSCNELSEVTLPENLPPKL 618
P T + +V H+N + + P+ + E I + LS N+LS LP +LPP L
Sbjct: 161 FPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLS--YLPPSLPPSL 218
Query: 619 QELDLTGN-----PRLVLDHKT 635
+ L L N PR L +T
Sbjct: 219 ERLHLQNNLISKVPRGALSRQT 240
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/405 (24%), Positives = 171/405 (42%), Gaps = 35/405 (8%)
Query: 175 LQRFTKLKSLNLSNNHLGDFPL-AVCSIPTLAELNVSCNALRSV-PAAVGVMHNLQTFLL 232
L FT+ +L++S N++ P A + P L EL ++ N L + P A+ + L+ L
Sbjct: 55 LSAFTQ--ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
Query: 233 DGNFLQSLPAE-LENMKQLSYLGLSFNEFTDIPE-VLEKLTAVDKLCMSGNCVETLRLQA 290
N L+++P+E + + L L L N T +PE E L + L + N + + +
Sbjct: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Query: 291 LRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFN---NIEVLHC 347
L +P ++ + L LN I + L + L L +NK+ L F+ N+E L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
Query: 348 ERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKL 407
N L G F +A+ A + L + N + +P+ + L
Sbjct: 233 NYNNL------GEFPQAIKALPS-------------LKELGFHSNSISVIPDGAFDGNPL 273
Query: 408 -EVLDIGHNQICELPARLFCN-SSLRKL-LAGHNQLARLPERLERTSVEVLDVQHNQLLE 464
+ + N + + F N S L L + G + + + P +E L + ++
Sbjct: 274 LRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISS 333
Query: 465 LPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHP 524
+P NL + LR L+ S N + LP S L+E+ L N + G
Sbjct: 334 IPNNLCQEQKMLRTLDLSYNNIRDLP----SFNGCHALEEISLQRNQIYQIKEGTFQGLI 389
Query: 525 HLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMN 569
L+IL ++ N + + A L + +D+S N+L + PT +N
Sbjct: 390 SLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLN 434
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/269 (27%), Positives = 126/269 (46%), Gaps = 14/269 (5%)
Query: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSS-LRKLLAGHNQLARL-P 444
+D S L VPE + S + LDI N I +LP F N L +L N L+ + P
Sbjct: 41 VDCSGKGLTAVPEGL--SAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHP 98
Query: 445 ERLERTS-VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQ 503
+ L ++VL +Q+NQL +P + +L+ L AN + S+P + L+
Sbjct: 99 KALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQ--LR 156
Query: 504 ELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAI 563
L+L +NSLT+ V L+ P L+ L +A N++ S P L L + L NK++++
Sbjct: 157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSL 216
Query: 564 PTTIMN-CRRMHTVIAHSNCIEVFPEVMQ-LPEIKCVDLSCNELSEVTLPENL---PPKL 618
+ + T+ + N + FP+ ++ LP +K + N +S +P+ P L
Sbjct: 217 SQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSIS--VIPDGAFDGNPLL 274
Query: 619 QELDLTGNPRLVLDHKTLELLNNIRCFKI 647
+ + L NP + + L+++ I
Sbjct: 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVI 303
Score = 73.6 bits (179), Expect = 1e-12
Identities = 82/383 (21%), Positives = 165/383 (43%), Gaps = 31/383 (8%)
Query: 234 GNFLQSLPAELENMKQLSYLGLSFNEFTDIPE-VLEKLTAVDKLCMSGNCVETLRLQALR 292
G L ++P L Q L +S N T +PE + +++L ++GN + + +AL
Sbjct: 45 GKGLTAVPEGLSAFTQA--LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALS 102
Query: 293 KMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQL 352
+ +K + L+ N ++ + ++ + L + L L N + + F + L
Sbjct: 103 GLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL------- 155
Query: 353 VTLDICGYFLKALYASSNELVQLDVYPVPNY--LSYMDVSRNRLENVPEWVCES-RKLEV 409
+ L+ N L ++ V+P+ N L + ++ N++ ++P++ + L V
Sbjct: 156 ----------RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVV 205
Query: 410 LDIGHNQICELPARLFCN-SSLRKLLAGHNQLARLPERLERT-SVEVLDVQHNQLLELPP 467
L + +N+I L F +L L +N L P+ ++ S++ L N + +P
Sbjct: 206 LHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPD 265
Query: 468 NLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLK 527
LR ++ N L + + ++ L L + S+ + P LTG HL+
Sbjct: 266 GAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD--LHSLVIRGASMVQQ-FPNLTGTVHLE 322
Query: 528 ILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP 587
L + ++ S P + + + L +DLS N ++ +P + C + + N I
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP-SFNGCHALEEISLQRNQIYQIK 381
Query: 588 E--VMQLPEIKCVDLSCNELSEV 608
E L ++ +DLS N + E+
Sbjct: 382 EGTFQGLISLRILDLSRNLIHEI 404
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/214 (21%), Positives = 86/214 (40%), Gaps = 50/214 (23%)
Query: 181 LKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAV------------------- 221
L++L+L+ N+LG+FP A+ ++P+L EL N++ +P
Sbjct: 227 LETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSF 286
Query: 222 ---GVMHNL--------------------------QTFLLDGNFLQSLPAEL-ENMKQLS 251
HNL ++ L G + S+P L + K L
Sbjct: 287 VGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLR 346
Query: 252 YLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLI 311
L LS+N D+P A++++ + N + ++ + + ++ +DL N+I ++
Sbjct: 347 TLDLSYNNIRDLPS-FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIH 405
Query: 312 ADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVL 345
+ L +T LD+ N+L N + L
Sbjct: 406 SRAFATLGPITNLDVSFNELTSFPTEGLNGLNQL 439
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 84.3 bits (207), Expect = 6e-16
Identities = 92/367 (25%), Positives = 161/367 (43%), Gaps = 32/367 (8%)
Query: 227 LQTFLLDGNFLQSL-PAELENMKQLSYLGLSFNEFTDIP-EVLEKLTAVDKLCMSGNCVE 284
LQ ++ + + ++ P ++ +L L LS N+ T +P +L+K+ +++L + N +
Sbjct: 76 LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALR 135
Query: 285 TLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFN---N 341
+ +K+ +++ + L N + L A L+++ LDL N L L +
Sbjct: 136 GIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAK 195
Query: 342 IEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENV-PEW 400
+E L N+LV+LD L S L +L + RN + ++ P
Sbjct: 196 LERLLLHSNRLVSLD------SGLLNSLGALTELQFH------------RNHIRSIAPGA 237
Query: 401 VCESRKLEVLDIGHNQICELPARLFCNS-SLRKLLAGHNQLARLPERL--ERTSVEVLDV 457
L L + N + LP+ LF +S +L L N LA LP L E ++ L +
Sbjct: 238 FDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWL 297
Query: 458 QHNQLLELPPNLLMKADSLRFLNASAN-KLESLPPATLSEETNSILQELYLTNNSLTDKC 516
QL LP LR+L + + +L +LP + LQ L L +N LT
Sbjct: 298 NRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAF--QGLGELQVLALHSNGLTALP 355
Query: 517 VPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNC--RRMH 574
LL G L+ + + NRL++ P + L LE + L N+L+ +P + R
Sbjct: 356 DGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTE 415
Query: 575 TVIAHSN 581
++ H++
Sbjct: 416 VLLGHNS 422
Score = 51.6 bits (122), Expect = 4e-06
Identities = 62/244 (25%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
+ + +DLS +L HLP L +Q L++ L N + GL L L L
Sbjct: 170 ENLKLLDLSGNNLTHLPKGLLGAQ----AKLERLLLHSNRLVSLDSGL--LNSLGALTEL 223
Query: 185 NLSNNHLGDF-PLAVCSIPTLAELNVSCNALRSVPAAV---------------------- 221
NH+ P A +P L+ L +S N L +P+A+
Sbjct: 224 QFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPG 283
Query: 222 ---GVMHNLQTFLLDGNFLQSLP-AELENMKQLSYLGLSFN-EFTDIPE-VLEKLTAVDK 275
G M LQ L+ L++LP A N+ +L YLG++ + + +P+ + L +
Sbjct: 284 VLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQV 343
Query: 276 LCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLD 335
L + N + L LR + ++ V LR N +R L L + + L N+L L
Sbjct: 344 LALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
Query: 336 AMIF 339
+F
Sbjct: 404 GDVF 407
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 84.3 bits (207), Expect = 6e-16
Identities = 102/381 (26%), Positives = 166/381 (43%), Gaps = 32/381 (8%)
Query: 116 LRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNEL 175
LRQ K+ ++L+ C L LP +F ++ L L+ + GL++L
Sbjct: 407 LRQ--KLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAIC-----DITFPPGLSQL 459
Query: 176 QRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGN 235
+L L+ S L F L V L + V C LR VP V + L+ L+G
Sbjct: 460 VHLQELSLLH-SPARL-PFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGL 517
Query: 236 FLQSLPA-----ELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQA 290
F Q L L +KQL L L N V + + +L + + + L +
Sbjct: 518 FPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNS 577
Query: 291 LRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERN 350
L+K+ ++ ++L + + I V L + +LDL+DN L ++ ++ HC +
Sbjct: 578 LKKLAALRELELVACGLER-IPHAVFSLGALQELDLKDNHLRSIEEIL----SFQHCRK- 631
Query: 351 QLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVL 410
LVTL + + + +L L+ YLSY N+LE +P + L +L
Sbjct: 632 -LVTLRLWHNQIAYVPEHVRKLRSLEQL----YLSY-----NKLETLPSQLGLCSGLRLL 681
Query: 411 DIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQLLELPPNL 469
D+ HN + LP + +L+ L +N L LPE L + L + NQL +L P+
Sbjct: 682 DVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH- 740
Query: 470 LMKADSLRFLNASANKLESLP 490
+ +L L N+LE+LP
Sbjct: 741 VGALRALSRLELKGNRLEALP 761
Score = 79.7 bits (195), Expect = 2e-14
Identities = 99/403 (24%), Positives = 168/403 (41%), Gaps = 64/403 (15%)
Query: 186 LSNNHLGDFPLAVCSIPTLAELNVSCNALRSV-----------PAAVGVMHNLQTFLLDG 234
L N G LA+C +P L + + + S+ P ++H + LL
Sbjct: 411 LQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHS 470
Query: 235 NFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLR----LQA 290
++ L + + E ++P + L +++L + G + L L++
Sbjct: 471 PARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES 530
Query: 291 LRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERN 350
LR++ +K + LR N K+ A D H+ +L L ++ + N+++ L R
Sbjct: 531 LRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHND---GARLVALNSLKKLAALRE 586
Query: 351 QLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVC--ESRKLE 408
+ L CG E + V+ + L +D+ N L ++ E + RKL
Sbjct: 587 --LELVACGL----------ERIPHAVFSL-GALQELDLKDNHLRSIEEILSFQHCRKLV 633
Query: 409 VLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLERTS-VEVLDVQHNQLLELPP 467
L + HNQI +P + SL +L +N+L LP +L S + +LDV HN L LPP
Sbjct: 634 TLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPP 693
Query: 468 NLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLK 527
+ + +L+ L S N LE+LP +EL+ T LL G L
Sbjct: 694 EVGL-LQNLQHLALSYNALEALP------------EELFFCRKLRT-----LLLGDNQLS 735
Query: 528 ILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNC 570
L + + L L ++L GN+L+A+P + NC
Sbjct: 736 QL-----------SPHVGALRALSRLELKGNRLEALPEELGNC 767
Score = 62.0 bits (149), Expect = 3e-09
Identities = 91/371 (24%), Positives = 163/371 (43%), Gaps = 54/371 (14%)
Query: 263 IPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT 322
+P+ + +L+ V+ L + C T L ++ H++ + L + R + +V H+
Sbjct: 429 LPDTVFELSEVESLRLEAICDITFP-PGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLK 487
Query: 323 QLDLRDNKLGDLDAMIFN--NIEVLHCER------NQLVTLDICGYF--LKALYASSNE- 371
+ ++ +L ++ +F +E LH E + TL+ LK L SN
Sbjct: 488 VMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAG 547
Query: 372 LVQLDVYPVPNYLSYM----DVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCN 427
V V V +L + D +R N + + R+LE++ G +I P +F
Sbjct: 548 KVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERI---PHAVFSL 604
Query: 428 SSLRKLLAGHNQLARLPERLERT---SVEVLDVQHNQLLELPPNLLMKADSLRFLNASAN 484
+L++L N L + E L + L + HNQ+ +P ++ K SL L S N
Sbjct: 605 GALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHV-RKLRSLEQLYLSYN 663
Query: 485 KLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKM 544
KLE+LP + L +G L++L +++N L S P ++
Sbjct: 664 KLETLPSQ------------------------LGLCSG---LRLLDVSHNGLHSLPP-EV 695
Query: 545 AKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCI-EVFPEVMQLPEIKCVDLSCN 603
L+ L+ + LS N L+A+P + CR++ T++ N + ++ P V L + ++L N
Sbjct: 696 GLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGN 755
Query: 604 ELSEVTLPENL 614
L LPE L
Sbjct: 756 RLE--ALPEEL 764
Score = 48.9 bits (115), Expect = 3e-05
Identities = 56/216 (25%), Positives = 84/216 (38%), Gaps = 45/216 (20%)
Query: 116 LRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNEL 175
L + K+A+ R ++L C LE +P +F L L+LK N LR + + + +L
Sbjct: 575 LNSLKKLAALR--ELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKL 632
Query: 176 -----------------QRFTKLKSLNLSNNHLGDFP--LAVCS---------------- 200
++ L+ L LS N L P L +CS
Sbjct: 633 VTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLP 692
Query: 201 -----IPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGL 255
+ L L +S NAL ++P + L+T LL N L L + ++ LS L L
Sbjct: 693 PEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLEL 752
Query: 256 SFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQAL 291
N +PE L + K +G VE Q L
Sbjct: 753 KGNRLEALPEELGNCGGLKK---AGLLVEDTLYQGL 785
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 83.2 bits (204), Expect = 1e-15
Identities = 130/544 (23%), Positives = 221/544 (40%), Gaps = 98/544 (18%)
Query: 140 LPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHL----GDF 194
+P N F + +L L L N L+ P + KL+ L+LS N L GD
Sbjct: 281 IPVNAFDALTELKVLRLHSNSLQHVPP-------RWFKNINKLQELDLSQNFLAKEIGDA 333
Query: 195 PLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLG 254
+ +P+L +L++S N LQ + N Q+ + L+++K L G
Sbjct: 334 KF-LHFLPSLIQLDLSFN------------FELQVYRASMNLSQAF-SSLKSLKILRIRG 379
Query: 255 LSFNEFTDIP-EVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLN-------- 305
F E L L ++ L + N ++ L ++ +K +DL +N
Sbjct: 380 YVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDS 439
Query: 306 -------------------VIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLH 346
V+ +L D + ++ ++ + + L
Sbjct: 440 SEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLD 499
Query: 347 CERNQLVTLDICGY----FLKALYASSNELVQL----DVYPVPNYLSYMDVSRNRLENVP 398
+N + + + FLK L S N + Q + P+ L Y+D S NRL+ +
Sbjct: 500 LSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAE-LRYLDFSNNRLDLLH 558
Query: 399 EWVCES-RKLEVLDIGHNQ-------ICELPARLFCNSSLRKLLAGHNQLARLPER-LER 449
E KLEVLDI N I + L+KL+ N ++ R +E
Sbjct: 559 STAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES 618
Query: 450 TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTN 509
S+ L+ + N L ++L + R+L N L+ L+EL ++
Sbjct: 619 ESLRTLEFRGNHL-----DVLWREGDNRYLQLFKNLLK--------------LEELDISK 659
Query: 510 NSLTDKCVPLLTGHP-HLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM 568
NSL+ + G P +LK L +A N L+SF K+ L+ LE +DLS N+L +P +
Sbjct: 660 NSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLS 719
Query: 569 NC-RRMHTVIAHSNCIEVFPE--VMQLPEIKCVDLSCNE---LSEVTLPENLPPKLQELD 622
NC R + +I +N I + + +++ +DLS N+ + + + PEN+ L+ L
Sbjct: 720 NCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLL 779
Query: 623 LTGN 626
L N
Sbjct: 780 LHHN 783
Score = 63.9 bits (154), Expect = 9e-10
Identities = 96/408 (23%), Positives = 170/408 (41%), Gaps = 54/408 (13%)
Query: 148 QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAEL 207
Q+L L+L NF++ L+ ++F +LK ++LS N + P S E+
Sbjct: 397 QNLEVLDLGTNFIK-------IANLSMFKQFKRLKVIDLSVNKIS--PSGDSS-----EV 442
Query: 208 NVSCNALRSVPA-AVGVMHNLQTFLLDGNF----LQSLPAELENMKQLSY-----LGLSF 257
NA SV + V+ L F D ++ A ++ + Y L LS
Sbjct: 443 GFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSK 502
Query: 258 NEFTDIPEV-LEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLNVIRKLIADEV 315
N + + L+ + L +SGN + +TL + + ++++D N + L +
Sbjct: 503 NSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAF 562
Query: 316 DFLQHVTQLDLRDNK-----------------LGDLDAMIFNNIEVLHC-----ERNQLV 353
+ L + LD+ N L L ++ N+ ++ E L
Sbjct: 563 EELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLR 622
Query: 354 TLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESR--KLEVLD 411
TL+ G L L+ + L ++ L +D+S+N L +P V + L+ L
Sbjct: 623 TLEFRGNHLDVLWREGDNRY-LQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLS 681
Query: 412 IGHNQICELP-ARLFCNSSLRKLLAGHNQLARLPERLERTS--VEVLDVQHNQLLELPPN 468
+ N + +L C +L L HNQL +PERL S ++ L +++NQ+ L
Sbjct: 682 LAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKY 741
Query: 469 LLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKC 516
L A LR+L+ S+NK++ + + E + L+ L L +N C
Sbjct: 742 FLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTC 789
Score = 49.7 bits (117), Expect = 2e-05
Identities = 64/278 (23%), Positives = 119/278 (42%), Gaps = 36/278 (12%)
Query: 299 HVDLRLNVIRKLIADEVDFLQHVTQLDLRDN----KLGDLDAMIFNNIEVLHCERNQLVT 354
++ L +N I + L H+ ++D R N LG + M +++ + L
Sbjct: 69 NLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLT- 127
Query: 355 LDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENV-PEWVCESRKLEVLDIG 413
+LK+LY N+L+++ +P L + + N + ++ E + E +E+L +G
Sbjct: 128 ------YLKSLYLDGNQLLEIP-QGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG 180
Query: 414 HNQICELPARL--------FCNSSLRKLLA-GHNQLARLPERLERTSVEVLDVQHNQLLE 464
N P + F N + K+L+ N + +P L T E L + +N + +
Sbjct: 181 QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTE-LYLYNNMIAK 239
Query: 465 LPPNLLMKADSLRFLNASAN--KLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTG 522
+ + + L+ L+ S N + + P + NS LQ ++LT+
Sbjct: 240 IQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTE-------- 291
Query: 523 HPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL 560
LK+L + N LQ P + +L+E+DLS N L
Sbjct: 292 ---LKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFL 326
Score = 31.6 bits (70), Expect = 4.8
Identities = 33/125 (26%), Positives = 51/125 (40%), Gaps = 17/125 (13%)
Query: 529 LHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCI---EV 585
L + N + + +L+ L EID N +P + + M CI ++
Sbjct: 70 LTLTINHIPDISPASFHRLDHLVEIDFRCN---CVPIPLGSKNNM--------CIKRLQI 118
Query: 586 FPEVMQ-LPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRC 644
P L +K + L N+L E+ P+ LPP LQ L L N + + L L NI
Sbjct: 119 KPRSFSGLTYLKSLYLDGNQLLEI--PQGLPPSLQLLSLEANNIFSIRKENLTELANIEI 176
Query: 645 FKIDQ 649
+ Q
Sbjct: 177 LYLGQ 181
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 82.4 bits (202), Expect = 2e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 17/180 (9%)
Query: 127 ISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQ---------- 176
++ ++L C LE +P +F +L L+LK N +R + + + L L
Sbjct: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
Query: 177 -------RFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQT 229
L+SL SNN L P+AV S+ L L+VS N + +P +G++ NLQ
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
Query: 230 FLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQ 289
+ GN + LP +L +L L L N T +PE + +L+ + +L + GNC++ L Q
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Score = 75.5 bits (184), Expect = 3e-13
Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 21/336 (6%)
Query: 149 DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPT-LAEL 207
DLT L++ + L +PA ++ + T L+ L+L + A + L L
Sbjct: 488 DLTDLDVLKLELIPEAKIPA-----KISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCL 542
Query: 208 NVSCNALRSVPAAVGVMHNLQTFLLDGNFLQ--SLPAELENMKQLSYLGLSF--NEFTDI 263
+V + +PA V ++ NL+ L GN + LE++++L +L + + T +
Sbjct: 543 HVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKV 602
Query: 264 PE-VLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT 322
P + + + KL + + + L L +L+KM ++ ++L+ N + I + L ++
Sbjct: 603 PSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQ-NCELERIPHAIFSLSNLQ 661
Query: 323 QLDLRDNKLGDLDAMI-FNNIEVLHCER---NQLVTLDICGYFLK---ALYASSNELVQL 375
+LDL+ N + ++ +I F +++ L C + N++VT+ +K +LY S+N+L L
Sbjct: 662 ELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESL 721
Query: 376 DVYPVP-NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLL 434
V L +DVS N + +P + + L+ L I N++ LP +LF LR L
Sbjct: 722 PVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLN 781
Query: 435 AGHNQLARLPERLERTS-VEVLDVQHNQLLELPPNL 469
G N + LPE++ + S + L+++ N L LP L
Sbjct: 782 LGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
Score = 74.3 bits (181), Expect = 6e-13
Identities = 102/463 (22%), Positives = 188/463 (40%), Gaps = 117/463 (25%)
Query: 191 LGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMK-- 248
L P AV + L L + +PA + M NLQ L PA++E
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533
Query: 249 ----QLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV----ETLRLQALRKMPHIKHV 300
L L + F + +IP + L + +L + GN + + L++LR++ H+K +
Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKIL 593
Query: 301 DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGY 360
++ N + K+ ++ D H+T+L V+H + +L+ L+
Sbjct: 594 HVKSN-LTKVPSNITDVAPHLTKL-------------------VIHNDGTKLLVLN---- 629
Query: 361 FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420
S ++ NV E ++ +LE +
Sbjct: 630 -----------------------------SLKKMMNVAELELQNCELE----------RI 650
Query: 421 PARLFCNSSLRKLLAGHNQLARLPERLERTSVE---VLDVQHNQLLELPPNLLMKADSLR 477
P +F S+L++L N + + E + ++ L + HN+++ +PP++ +L
Sbjct: 651 PHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSIT-HVKNLE 709
Query: 478 FLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQ 537
L S NKLESLP A S LQ+L + L ++YN +
Sbjct: 710 SLYFSNNKLESLPVAVFS------LQKL---------------------RCLDVSYNNIS 742
Query: 538 SFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIK 596
P ++ L+ L+ + ++GNK+ +P + C ++ T+ NCI PE V QL ++
Sbjct: 743 MIPI-EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLT 801
Query: 597 CVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELL 639
++L N L + LP +L + + LV++ + L
Sbjct: 802 QLELKGNCL------DRLPAQLGQCRMLKKSGLVVEDHLFDTL 838
Score = 49.3 bits (116), Expect = 2e-05
Identities = 43/149 (28%), Positives = 65/149 (43%), Gaps = 11/149 (7%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
+ + S+ S LE LP +F Q L L++ N + P E+ L+ L
Sbjct: 706 KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI--------EIGLLQNLQHL 757
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
+++ N + P + L LN+ N + S+P VG + L L GN L LPA+L
Sbjct: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
Query: 245 ENMKQLSYLGLSFNE--FTDIP-EVLEKL 270
+ L GL + F +P EV E L
Sbjct: 818 GQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846
Score = 43.5 bits (101), Expect = 0.001
Identities = 31/129 (24%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 119 VSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRF 178
V+ + Q++ +D+S ++ +P + Q+L HL++ N + P +L +
Sbjct: 723 VAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILP--------KQLFKC 774
Query: 179 TKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQT--FLLDGNF 236
KL++LNL N + P V + L +L + N L +PA +G L+ +++ +
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHL 834
Query: 237 LQSLPAELE 245
+LP E++
Sbjct: 835 FDTLPLEVK 843
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 82.4 bits (202), Expect = 2e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 17/180 (9%)
Query: 127 ISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQ---------- 176
++ ++L C LE +P +F +L L+LK N +R + + + L L
Sbjct: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
Query: 177 -------RFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQT 229
L+SL SNN L P+AV S+ L L+VS N + +P +G++ NLQ
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
Query: 230 FLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQ 289
+ GN + LP +L +L L L N T +PE + +L+ + +L + GNC++ L Q
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Score = 75.5 bits (184), Expect = 3e-13
Identities = 88/336 (26%), Positives = 165/336 (49%), Gaps = 21/336 (6%)
Query: 149 DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPT-LAEL 207
DLT L++ + L +PA ++ + T L+ L+L + A + L L
Sbjct: 488 DLTDLDVLKLELIPEAKIPA-----KISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCL 542
Query: 208 NVSCNALRSVPAAVGVMHNLQTFLLDGNFLQ--SLPAELENMKQLSYLGLSF--NEFTDI 263
+V + +PA V ++ NL+ L GN + LE++++L +L + + T +
Sbjct: 543 HVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKV 602
Query: 264 PE-VLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT 322
P + + + KL + + + L L +L+KM ++ ++L+ N + I + L ++
Sbjct: 603 PSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQ-NCELERIPHAIFSLSNLQ 661
Query: 323 QLDLRDNKLGDLDAMI-FNNIEVLHCER---NQLVTLDICGYFLK---ALYASSNELVQL 375
+LDL+ N + ++ +I F +++ L C + N++VT+ +K +LY S+N+L L
Sbjct: 662 ELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESL 721
Query: 376 DVYPVP-NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLL 434
V L +DVS N + +P + + L+ L I N++ LP +LF LR L
Sbjct: 722 PVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLN 781
Query: 435 AGHNQLARLPERLERTS-VEVLDVQHNQLLELPPNL 469
G N + LPE++ + S + L+++ N L LP L
Sbjct: 782 LGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
Score = 74.3 bits (181), Expect = 6e-13
Identities = 102/463 (22%), Positives = 188/463 (40%), Gaps = 117/463 (25%)
Query: 191 LGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMK-- 248
L P AV + L L + +PA + M NLQ L PA++E
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533
Query: 249 ----QLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV----ETLRLQALRKMPHIKHV 300
L L + F + +IP + L + +L + GN + + L++LR++ H+K +
Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKIL 593
Query: 301 DLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGY 360
++ N + K+ ++ D H+T+L V+H + +L+ L+
Sbjct: 594 HVKSN-LTKVPSNITDVAPHLTKL-------------------VIHNDGTKLLVLN---- 629
Query: 361 FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420
S ++ NV E ++ +LE +
Sbjct: 630 -----------------------------SLKKMMNVAELELQNCELE----------RI 650
Query: 421 PARLFCNSSLRKLLAGHNQLARLPERLERTSVE---VLDVQHNQLLELPPNLLMKADSLR 477
P +F S+L++L N + + E + ++ L + HN+++ +PP++ +L
Sbjct: 651 PHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSIT-HVKNLE 709
Query: 478 FLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQ 537
L S NKLESLP A S LQ+L + L ++YN +
Sbjct: 710 SLYFSNNKLESLPVAVFS------LQKL---------------------RCLDVSYNNIS 742
Query: 538 SFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIK 596
P ++ L+ L+ + ++GNK+ +P + C ++ T+ NCI PE V QL ++
Sbjct: 743 MIPI-EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLT 801
Query: 597 CVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELL 639
++L N L + LP +L + + LV++ + L
Sbjct: 802 QLELKGNCL------DRLPAQLGQCRMLKKSGLVVEDHLFDTL 838
Score = 49.3 bits (116), Expect = 2e-05
Identities = 43/149 (28%), Positives = 65/149 (43%), Gaps = 11/149 (7%)
Query: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSL 184
+ + S+ S LE LP +F Q L L++ N + P E+ L+ L
Sbjct: 706 KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI--------EIGLLQNLQHL 757
Query: 185 NLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL 244
+++ N + P + L LN+ N + S+P VG + L L GN L LPA+L
Sbjct: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
Query: 245 ENMKQLSYLGLSFNE--FTDIP-EVLEKL 270
+ L GL + F +P EV E L
Sbjct: 818 GQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846
Score = 43.5 bits (101), Expect = 0.001
Identities = 31/129 (24%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 119 VSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRF 178
V+ + Q++ +D+S ++ +P + Q+L HL++ N + P +L +
Sbjct: 723 VAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILP--------KQLFKC 774
Query: 179 TKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQT--FLLDGNF 236
KL++LNL N + P V + L +L + N L +PA +G L+ +++ +
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHL 834
Query: 237 LQSLPAELE 245
+LP E++
Sbjct: 835 FDTLPLEVK 843
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,793,765
Number of Sequences: 37866
Number of extensions: 2456851
Number of successful extensions: 17383
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 241
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 12512
Number of HSP's gapped (non-prelim): 2524
length of query: 1205
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1091
effective length of database: 13,930,794
effective search space: 15198496254
effective search space used: 15198496254
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.