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Search of human proteins with 36950991
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|36950991 nuclear receptor subfamily 2, group C, member 2
[Homo sapiens]
(615 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Hom... 1210 0.0
gi|189491739 nuclear receptor subfamily 2, group C, member 1 iso... 707 0.0
gi|189491766 nuclear receptor subfamily 2, group C, member 1 iso... 505 e-143
gi|73808084 nuclear receptor subfamily 2, group C, member 1 isof... 503 e-142
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 149 1e-35
gi|223555953 nuclear receptor subfamily 2, group F, member 2 iso... 146 5e-35
gi|223555951 nuclear receptor subfamily 2, group F, member 2 iso... 146 5e-35
gi|223555949 nuclear receptor subfamily 2, group F, member 2 iso... 146 5e-35
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 146 5e-35
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 136 6e-32
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 134 2e-31
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 134 2e-31
gi|11415052 retinoid X receptor, beta [Homo sapiens] 126 5e-29
gi|19743907 RAR-related orphan receptor B [Homo sapiens] 125 1e-28
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 122 7e-28
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 122 7e-28
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 122 7e-28
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 122 7e-28
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 122 7e-28
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 122 7e-28
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 122 7e-28
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 122 1e-27
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 122 1e-27
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 122 1e-27
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 120 5e-27
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 119 6e-27
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 119 6e-27
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 118 2e-26
gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens] 112 8e-25
gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens] 111 2e-24
>gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Homo
sapiens]
Length = 615
Score = 1210 bits (3130), Expect = 0.0
Identities = 615/615 (100%), Positives = 615/615 (100%)
Query: 1 MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQTGQKIQIVTAV 60
MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQTGQKIQIVTAV
Sbjct: 1 MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQTGQKIQIVTAV 60
Query: 61 DASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVER 120
DASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVER
Sbjct: 61 DASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVER 120
Query: 121 LLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCII 180
LLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCII
Sbjct: 121 LLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCII 180
Query: 181 NKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPL 240
NKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPL
Sbjct: 181 NKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPL 240
Query: 241 IATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVV 300
IATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVV
Sbjct: 241 IATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVV 300
Query: 301 TSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGG 360
TSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGG
Sbjct: 301 TSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGG 360
Query: 361 SIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWA 420
SIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWA
Sbjct: 361 SIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWA 420
Query: 421 RSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLS 480
RSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLS
Sbjct: 421 RSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLS 480
Query: 481 GDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKA 540
GDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKA
Sbjct: 481 GDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKA 540
Query: 541 QMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILK 600
QMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILK
Sbjct: 541 QMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILK 600
Query: 601 METAEYNGQITGASL 615
METAEYNGQITGASL
Sbjct: 601 METAEYNGQITGASL 615
>gi|189491739 nuclear receptor subfamily 2, group C, member 1
isoform a [Homo sapiens]
Length = 603
Score = 707 bits (1826), Expect = 0.0
Identities = 375/601 (62%), Positives = 452/601 (75%), Gaps = 43/601 (7%)
Query: 43 KIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILA------------SPET 90
+IVT+QQTGQKIQIVTA+D + KQ FILT+ DG+ KVILA +P+
Sbjct: 18 EIVTEQQTGQKIQIVTALDHNTQGKQ-FILTNHDGSTPSKVILARQDSTPGKVFLTTPDA 76
Query: 91 SSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGA 150
+ QL FTT D L +Q++TD++ D +V + CVVCGDKASGRHYGA
Sbjct: 77 AGVNQLFFTTPD-LSAQHLQLLTDNSP--------DQGPNKVFDLCVVCGDKASGRHYGA 127
Query: 151 VSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSER 210
V+CEGCKGFFKRS+RKNL YSCR ++DCIINKHHRNRCQ+CRL++C+ GMK +SVQ ER
Sbjct: 128 VTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCER 187
Query: 211 KPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQP 270
KP +V REK SNCAASTEKIYIRKDLRSPL ATPTFV D + R TGLLD GM +NI
Sbjct: 188 KPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPS 247
Query: 271 LIREDGTVLLATDSKAETSQGALGTLANVVTSLANLS---------------ESLNNGDT 315
++ + VL+ +D KAE+ QG L TLANVVTSLANL ESL+N DT
Sbjct: 248 GVKTESAVLMTSD-KAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDT 306
Query: 316 SEIQ-PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPII 374
S + E Q+ +++RAFDTLAKALN +S++ S G++ GS+H+I+ D S
Sbjct: 307 SLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGME----GSVHLITGDSSINYT 362
Query: 375 EVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCN 434
E EGPLLSD+HV F+LTMPSPMPEYLNVHYI ESASRLLFLSMHWA SIP+FQALGQ+ +
Sbjct: 363 EKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENS 422
Query: 435 TSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKL 494
SLV+A WNELFTLGLAQC QVM+++TILA VN L NS+Q+DK+S +R K +MEHI+KL
Sbjct: 423 ISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKL 482
Query: 495 QEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSE 554
QEFCNSM KL IDGYEYAYLKAIVLFSPDHP L + QIEKFQEKA +E QDY+ KTY +
Sbjct: 483 QEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIEKFQEKAYVEFQDYITKTYPD 542
Query: 555 DTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGAS 614
DTYRL+R+L+RLPALRLM++ ITEELFF GLIGN+ IDS+IP+ILKME A+YN QI G S
Sbjct: 543 DTYRLSRLLLRLPALRLMNATITEELFFKGLIGNIRIDSVIPHILKMEPADYNSQIIGHS 602
Query: 615 L 615
+
Sbjct: 603 I 603
>gi|189491766 nuclear receptor subfamily 2, group C, member 1
isoform c [Homo sapiens]
Length = 483
Score = 505 bits (1301), Expect = e-143
Identities = 275/463 (59%), Positives = 334/463 (72%), Gaps = 43/463 (9%)
Query: 43 KIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILA------------SPET 90
+IVT+QQTGQKIQIVTA+D + KQ FILT+ DG+ KVILA +P+
Sbjct: 18 EIVTEQQTGQKIQIVTALDHNTQGKQ-FILTNHDGSTPSKVILARQDSTPGKVFLTTPDA 76
Query: 91 SSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGA 150
+ QL FTT D L +Q++TD++ D +V + CVVCGDKASGRHYGA
Sbjct: 77 AGVNQLFFTTPD-LSAQHLQLLTDNSP--------DQGPNKVFDLCVVCGDKASGRHYGA 127
Query: 151 VSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSER 210
V+CEGCKGFFKRS+RKNL YSCR ++DCIINKHHRNRCQ+CRL++C+ GMK +SVQ ER
Sbjct: 128 VTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCER 187
Query: 211 KPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQP 270
KP +V REK SNCAASTEKIYIRKDLRSPL ATPTFV D + R TGLLD GM +NI
Sbjct: 188 KPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPS 247
Query: 271 LIREDGTVLLATDSKAETSQGALGTLANVVTSLANLS---------------ESLNNGDT 315
++ + VL+ +D KAE+ QG L TLANVVTSLANL ESL+N DT
Sbjct: 248 GVKTESAVLMTSD-KAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDT 306
Query: 316 SEIQ-PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPII 374
S + E Q+ +++RAFDTLAKALN +S++ S G++ GS+H+I+ D S
Sbjct: 307 SLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGME----GSVHLITGDSSINYT 362
Query: 375 EVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCN 434
E EGPLLSD+HV F+LTMPSPMPEYLNVHYI ESASRLLFLSMHWA SIP+FQALGQ+ +
Sbjct: 363 EKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENS 422
Query: 435 TSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQED 477
SLV+A WNELFTLGLAQC QVM+++TILA VN L NS+Q+D
Sbjct: 423 ISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQD 465
>gi|73808084 nuclear receptor subfamily 2, group C, member 1 isoform
b [Homo sapiens]
Length = 467
Score = 503 bits (1295), Expect = e-142
Identities = 274/462 (59%), Positives = 333/462 (72%), Gaps = 43/462 (9%)
Query: 43 KIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILA------------SPET 90
+IVT+QQTGQKIQIVTA+D + KQ FILT+ DG+ KVILA +P+
Sbjct: 18 EIVTEQQTGQKIQIVTALDHNTQGKQ-FILTNHDGSTPSKVILARQDSTPGKVFLTTPDA 76
Query: 91 SSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGA 150
+ QL FTT D L +Q++TD++ D +V + CVVCGDKASGRHYGA
Sbjct: 77 AGVNQLFFTTPD-LSAQHLQLLTDNSP--------DQGPNKVFDLCVVCGDKASGRHYGA 127
Query: 151 VSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSER 210
V+CEGCKGFFKRS+RKNL YSCR ++DCIINKHHRNRCQ+CRL++C+ GMK +SVQ ER
Sbjct: 128 VTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCER 187
Query: 211 KPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQP 270
KP +V REK SNCAASTEKIYIRKDLRSPL ATPTFV D + R TGLLD GM +NI
Sbjct: 188 KPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPS 247
Query: 271 LIREDGTVLLATDSKAETSQGALGTLANVVTSLANLS---------------ESLNNGDT 315
++ + VL+ +D KAE+ QG L TLANVVTSLANL ESL+N DT
Sbjct: 248 GVKTESAVLMTSD-KAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDT 306
Query: 316 SEIQ-PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPII 374
S + E Q+ +++RAFDTLAKALN +S++ S G++ GS+H+I+ D S
Sbjct: 307 SLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGME----GSVHLITGDSSINYT 362
Query: 375 EVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCN 434
E EGPLLSD+HV F+LTMPSPMPEYLNVHYI ESASRLLFLSMHWA SIP+FQALGQ+ +
Sbjct: 363 EKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENS 422
Query: 435 TSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQE 476
SLV+A WNELFTLGLAQC QVM+++TILA VN L NS+Q+
Sbjct: 423 ISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQ 464
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 149 bits (375), Expect = 1e-35
Identities = 79/196 (40%), Positives = 117/196 (59%), Gaps = 6/196 (3%)
Query: 400 LNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL 459
+ + ICE A+RLLF ++ WAR+IP F L SL+R W+ELF L AQC+ + +
Sbjct: 214 MGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHV 273
Query: 460 STILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 519
+ +LAA H +S DR+ M+HI QE + L +D EY+ LKAIVL
Sbjct: 274 APLLAAAGLHAS------PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 327
Query: 520 FSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEE 579
F+ D GL+ + IE QEK+Q L++YV+ Y R ++L+RLP+LR +SS++ E+
Sbjct: 328 FTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQ 387
Query: 580 LFFTGLIGNVSIDSII 595
LFF L+G I+++I
Sbjct: 388 LFFVRLVGKTPIETLI 403
Score = 131 bits (329), Expect = 2e-30
Identities = 56/85 (65%), Positives = 73/85 (85%), Gaps = 1/85 (1%)
Query: 128 QRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNR 187
Q Q +E CVVCGDK+SG+HYG +CEGCK FFKRSVR+NLTY+CR+N++C I++HHRN+
Sbjct: 79 QSQQHIE-CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQ 137
Query: 188 CQFCRLKKCLEMGMKMESVQSERKP 212
CQ+CRLKKCL++GM+ E+VQ R P
Sbjct: 138 CQYCRLKKCLKVGMRREAVQRGRMP 162
>gi|223555953 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 146 bits (369), Expect = 5e-35
Identities = 76/196 (38%), Positives = 117/196 (59%), Gaps = 6/196 (3%)
Query: 400 LNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL 459
+ + ICE A+R+LF ++ WAR+IP F L +L+R W+ELF L AQC+ + +
Sbjct: 54 MGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHV 113
Query: 460 STILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 519
+ +LAA H +S DR+ M+HI QE + L +D EY+ LKAIVL
Sbjct: 114 APLLAAAGLHAS------PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 167
Query: 520 FSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEE 579
F+ D GL+ + +E QEK+Q L++YV+ Y R ++L+RLP+LR +SS++ E+
Sbjct: 168 FTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQ 227
Query: 580 LFFTGLIGNVSIDSII 595
LFF L+G I+++I
Sbjct: 228 LFFVRLVGKTPIETLI 243
>gi|223555951 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 146 bits (369), Expect = 5e-35
Identities = 76/196 (38%), Positives = 117/196 (59%), Gaps = 6/196 (3%)
Query: 400 LNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL 459
+ + ICE A+R+LF ++ WAR+IP F L +L+R W+ELF L AQC+ + +
Sbjct: 54 MGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHV 113
Query: 460 STILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 519
+ +LAA H +S DR+ M+HI QE + L +D EY+ LKAIVL
Sbjct: 114 APLLAAAGLHAS------PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 167
Query: 520 FSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEE 579
F+ D GL+ + +E QEK+Q L++YV+ Y R ++L+RLP+LR +SS++ E+
Sbjct: 168 FTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQ 227
Query: 580 LFFTGLIGNVSIDSII 595
LFF L+G I+++I
Sbjct: 228 LFFVRLVGKTPIETLI 243
>gi|223555949 nuclear receptor subfamily 2, group F, member 2
isoform b [Homo sapiens]
Length = 281
Score = 146 bits (369), Expect = 5e-35
Identities = 76/196 (38%), Positives = 117/196 (59%), Gaps = 6/196 (3%)
Query: 400 LNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL 459
+ + ICE A+R+LF ++ WAR+IP F L +L+R W+ELF L AQC+ + +
Sbjct: 74 MGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHV 133
Query: 460 STILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 519
+ +LAA H +S DR+ M+HI QE + L +D EY+ LKAIVL
Sbjct: 134 APLLAAAGLHAS------PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 187
Query: 520 FSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEE 579
F+ D GL+ + +E QEK+Q L++YV+ Y R ++L+RLP+LR +SS++ E+
Sbjct: 188 FTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQ 247
Query: 580 LFFTGLIGNVSIDSII 595
LFF L+G I+++I
Sbjct: 248 LFFVRLVGKTPIETLI 263
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 146 bits (369), Expect = 5e-35
Identities = 76/196 (38%), Positives = 117/196 (59%), Gaps = 6/196 (3%)
Query: 400 LNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL 459
+ + ICE A+R+LF ++ WAR+IP F L +L+R W+ELF L AQC+ + +
Sbjct: 207 MGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHV 266
Query: 460 STILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 519
+ +LAA H +S DR+ M+HI QE + L +D EY+ LKAIVL
Sbjct: 267 APLLAAAGLHAS------PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 320
Query: 520 FSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEE 579
F+ D GL+ + +E QEK+Q L++YV+ Y R ++L+RLP+LR +SS++ E+
Sbjct: 321 FTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQ 380
Query: 580 LFFTGLIGNVSIDSII 595
LFF L+G I+++I
Sbjct: 381 LFFVRLVGKTPIETLI 396
Score = 132 bits (331), Expect = 1e-30
Identities = 59/107 (55%), Positives = 79/107 (73%), Gaps = 8/107 (7%)
Query: 125 TDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHH 184
+D Q+ Q CVVCGDK+SG+HYG +CEGCK FFKRSVR+NL+Y+CR+N++C I++HH
Sbjct: 68 SDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHH 127
Query: 185 RNRCQFCRLKKCLEMGMKMESVQSERKP--------FDVQREKPSNC 223
RN+CQ+CRLKKCL++GM+ E+VQ R P F + P NC
Sbjct: 128 RNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNC 174
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 136 bits (342), Expect = 6e-32
Identities = 82/212 (38%), Positives = 118/212 (55%), Gaps = 15/212 (7%)
Query: 58 TAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNL-VPGRIQIVTDSA 116
T ++A GSP + ++TS G +G LA+P + L+ S L V + D
Sbjct: 61 TPLNALGSPYR--VITSAMGPPSGA--LAAPPGIN---LVAPPSSQLNVVNSVSSSEDIK 113
Query: 117 SVERLLGKTDVQRPQ------VVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTY 170
+ L G ++ P V C +CGD++SG+HYG SCEGCKGFFKR++RK+L Y
Sbjct: 114 PLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIY 173
Query: 171 SCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAAS-TEK 229
+CR N+DC+I+K RNRCQ+CR +KCL MGMK E+VQ ER+ + E + CA S E
Sbjct: 174 TCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHED 233
Query: 230 IYIRKDLRSPLIATPTFVADKDGARQTGLLDP 261
+ + + L + L P + D + DP
Sbjct: 234 MPVERILEAELAVEPKTESYGDMNMENSTNDP 265
Score = 107 bits (266), Expect = 4e-23
Identities = 73/207 (35%), Positives = 102/207 (49%), Gaps = 12/207 (5%)
Query: 405 ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILA 464
IC +A + LF + WA+ IP F L + L+RA WNEL + V IL
Sbjct: 269 ICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSH-RSVSVQDGILL 327
Query: 465 AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDH 524
A H+ S G +V L E + M + +D E L+AIVLF+PD
Sbjct: 328 ATGLHVHRSSAHSAGVGSIFDRV------LTELVSKMKDMQMDKSELGCLRAIVLFNPDA 381
Query: 525 PGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTG 584
GL++ S++E +EK L+ Y ++ Y E R A++L+RLPALR + E LFF
Sbjct: 382 KGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFK 441
Query: 585 LIGNVSIDSIIPYILKMETAEYNGQIT 611
LIG+ ID+ + ME E QIT
Sbjct: 442 LIGDTPIDTFL-----MEMLETPLQIT 463
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 134 bits (337), Expect = 2e-31
Identities = 81/223 (36%), Positives = 119/223 (53%), Gaps = 25/223 (11%)
Query: 64 GSPKQQF----ILTSP-DGAGTGKVILASP------ETSSAKQLIFTTSDNLVPGRIQIV 112
GSP Q L+SP +G G +++SP + L F+T + + V
Sbjct: 42 GSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPV 101
Query: 113 TDSASVERLLGKTDVQRPQV----------VEYCVVCGDKASGRHYGAVSCEGCKGFFKR 162
+ S ++ LG V + C +CGD++SG+HYG SCEGCKGFFKR
Sbjct: 102 SSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKR 161
Query: 163 SVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSER-KPFDVQREKPS 221
+VRK+LTY+CR N+DC+I+K RNRCQ+CR +KCL MGMK E+VQ ER + D +
Sbjct: 162 TVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVE 221
Query: 222 NCAASTEKIYIRKDLRSPLIATP---TFVADKDGARQTGLLDP 261
+ +++ E + + + L + L P T+V G + DP
Sbjct: 222 STSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDP 264
Score = 107 bits (268), Expect = 2e-23
Identities = 66/198 (33%), Positives = 103/198 (52%), Gaps = 11/198 (5%)
Query: 405 ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILA 464
IC++A + LF + WA+ IP F L D L+RA WNEL + + + +LA
Sbjct: 268 ICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLA 327
Query: 465 AIVNHLQNSIQEDKLSG--DRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSP 522
++ +NS + DR+ L E + M + +D E L+AIVLF+P
Sbjct: 328 TGLHVHRNSAHSAGVGAIFDRV---------LTELVSKMRDMQMDKTELGCLRAIVLFNP 378
Query: 523 DHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFF 582
D GL++ +++E +EK L+ Y + Y E R A++L+RLPALR + E LFF
Sbjct: 379 DSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFF 438
Query: 583 TGLIGNVSIDSIIPYILK 600
LIG+ ID+ + +L+
Sbjct: 439 FKLIGDTPIDTFLMEMLE 456
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 134 bits (337), Expect = 2e-31
Identities = 59/102 (57%), Positives = 78/102 (76%), Gaps = 4/102 (3%)
Query: 126 DVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHR 185
D +RP + CVVCGDK+SG+HYG +CEGCK FFKRS+R+NL+Y+CRSN+DC I++HHR
Sbjct: 46 DEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHR 105
Query: 186 NRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAAST 227
N+CQ+CRLKKC +GM+ E+VQ R P + P AAS+
Sbjct: 106 NQCQYCRLKKCFRVGMRKEAVQRGRIPHSL----PGAVAASS 143
Score = 134 bits (337), Expect = 2e-31
Identities = 72/196 (36%), Positives = 110/196 (56%), Gaps = 6/196 (3%)
Query: 400 LNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSL 459
L + +CE A+RLLF ++ WAR P F L +L+R W+ELF L AQ A +
Sbjct: 197 LGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHT 256
Query: 460 STILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 519
+ +LAA H ++ +R M+ + QE + + +L +D EY LKAI L
Sbjct: 257 APLLAAAGLHAA------PMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIAL 310
Query: 520 FSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEE 579
F+PD GL+ + +E QEKAQ+ L +YV+ Y R R+L+RLPALR + +++ +
Sbjct: 311 FTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQ 370
Query: 580 LFFTGLIGNVSIDSII 595
LFF L+G I+++I
Sbjct: 371 LFFMRLVGKTPIETLI 386
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 126 bits (317), Expect = 5e-29
Identities = 50/76 (65%), Positives = 64/76 (84%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD++SG+HYG SCEGCKGFFKR++RK+LTYSCR N+DC ++K RNRCQ+CR +K
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQK 264
Query: 196 CLEMGMKMESVQSERK 211
CL GMK E+VQ ER+
Sbjct: 265 CLATGMKREAVQEERQ 280
Score = 107 bits (267), Expect = 3e-23
Identities = 66/198 (33%), Positives = 105/198 (53%), Gaps = 11/198 (5%)
Query: 405 ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILA 464
IC++A + LF + WA+ IP F +L D L+RA WNEL + + + +LA
Sbjct: 339 ICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLA 398
Query: 465 AIVNHLQNSIQEDKLSG--DRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSP 522
++ +NS + DR+ L E + M + +D E L+AI+LF+P
Sbjct: 399 TGLHVHRNSAHSAGVGAIFDRV---------LTELVSKMRDMRMDKTELGCLRAIILFNP 449
Query: 523 DHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFF 582
D GL++ S++E +EK L+ Y ++ Y E R A++L+RLPALR + E LFF
Sbjct: 450 DAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFF 509
Query: 583 TGLIGNVSIDSIIPYILK 600
LIG+ ID+ + +L+
Sbjct: 510 FKLIGDTPIDTFLMEMLE 527
>gi|19743907 RAR-related orphan receptor B [Homo sapiens]
Length = 459
Score = 125 bits (314), Expect = 1e-28
Identities = 120/460 (26%), Positives = 209/460 (45%), Gaps = 57/460 (12%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGDK+SG HYG ++CEGCKGFF+RS + N +YSC ++C+I++ +RNRCQ CRL+K
Sbjct: 10 CKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQK 69
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQ 255
CL +GM ++V+ R + +++ + A +K R + +Q
Sbjct: 70 CLALGMSRDAVKFGR----MSKKQRDSLYAEVQKHQQR--------------LQEQRQQQ 111
Query: 256 TGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDT 315
+G + L + I ++ ETS GT AN SE N D+
Sbjct: 112 SG--EAEALARVYSSSISNG-----LSNLNNETS----GTYANGHVIDLPKSEGYYNVDS 160
Query: 316 SEIQPEDQSASEIT--------RAFD-TLAKALNTTDSSSSPSLADGIDTSGGGSIHVIS 366
+ P DQS ++T +D T L T S ++ LA GI + I I+
Sbjct: 161 GQPSP-DQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMT---EIDRIA 216
Query: 367 RDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAF 426
++ +E + + H +L + E + + +S SR + A
Sbjct: 217 QNIIKSHLETCQYTMEELH---QLAWQTHTYEEIKAY---QSKSREALWQQCAIQITHAI 270
Query: 427 QALGQDCN--TSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQ-EDKLSGDR 483
Q + + T + C N+ L + C +V+ + + N L N++ E K G +
Sbjct: 271 QYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVR--MCRAFNPLNNTVLFEGKYGGMQ 328
Query: 484 IKQVM---EHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKA 540
+ + + + + + +F ++ L + E A + VL SPD L +++K QEK
Sbjct: 329 MFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKI 388
Query: 541 QMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEEL 580
LQ +QK + +D LA+++ ++P + + + E+L
Sbjct: 389 YFALQHVIQKNHLDDE-TLAKLIAKIPTITAVCNLHGEKL 427
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 122 bits (307), Expect = 7e-28
Identities = 51/109 (46%), Positives = 76/109 (69%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD+A+G+HYGA SC+GCKGFF+RSVRKN YSCR ++ C+++K RN+C++CRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATP 244
C GMK E+VQ+ER +R + + + ++ ++ S I +P
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSP 168
Score = 91.7 bits (226), Expect = 2e-18
Identities = 68/270 (25%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query: 333 DTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTM 392
D ++ ++ + SS PS+ + V+SR ++P+ + G + +
Sbjct: 135 DRISTRRSSYEDSSLPSINALLQAE------VLSRQITSPVSGINGDIRAK--------- 179
Query: 393 PSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ 452
+ ++ +CES L + + WA+ IPAF L D +L+RA E LG +
Sbjct: 180 -----KIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 234
Query: 453 CAQVMSLSTILA---AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGY 509
+ V +L + H + ++S I L E +L ID
Sbjct: 235 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----------IRILDELVLPFQELQIDDN 284
Query: 510 EYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPAL 569
EYAYLKAI+ F PD GL+ +I++ + + Q+ L+DY+ + R +L+ LP L
Sbjct: 285 EYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 344
Query: 570 RLMSSNITEELFFTGLIGNVSIDSIIPYIL 599
+ ++ + E++ F L G ID+++ +L
Sbjct: 345 QSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 122 bits (307), Expect = 7e-28
Identities = 51/109 (46%), Positives = 76/109 (69%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD+A+G+HYGA SC+GCKGFF+RSVRKN YSCR ++ C+++K RN+C++CRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATP 244
C GMK E+VQ+ER +R + + + ++ ++ S I +P
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSP 168
Score = 91.7 bits (226), Expect = 2e-18
Identities = 68/270 (25%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query: 333 DTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTM 392
D ++ ++ + SS PS+ + V+SR ++P+ + G + +
Sbjct: 135 DRISTRRSSYEDSSLPSINALLQAE------VLSRQITSPVSGINGDIRAK--------- 179
Query: 393 PSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ 452
+ ++ +CES L + + WA+ IPAF L D +L+RA E LG +
Sbjct: 180 -----KIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 234
Query: 453 CAQVMSLSTILA---AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGY 509
+ V +L + H + ++S I L E +L ID
Sbjct: 235 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----------IRILDELVLPFQELQIDDN 284
Query: 510 EYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPAL 569
EYAYLKAI+ F PD GL+ +I++ + + Q+ L+DY+ + R +L+ LP L
Sbjct: 285 EYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 344
Query: 570 RLMSSNITEELFFTGLIGNVSIDSIIPYIL 599
+ ++ + E++ F L G ID+++ +L
Sbjct: 345 QSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 122 bits (307), Expect = 7e-28
Identities = 51/109 (46%), Positives = 76/109 (69%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD+A+G+HYGA SC+GCKGFF+RSVRKN YSCR ++ C+++K RN+C++CRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATP 244
C GMK E+VQ+ER +R + + + ++ ++ S I +P
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSP 168
Score = 91.7 bits (226), Expect = 2e-18
Identities = 68/270 (25%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query: 333 DTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTM 392
D ++ ++ + SS PS+ + V+SR ++P+ + G + +
Sbjct: 135 DRISTRRSSYEDSSLPSINALLQAE------VLSRQITSPVSGINGDIRAK--------- 179
Query: 393 PSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ 452
+ ++ +CES L + + WA+ IPAF L D +L+RA E LG +
Sbjct: 180 -----KIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 234
Query: 453 CAQVMSLSTILA---AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGY 509
+ V +L + H + ++S I L E +L ID
Sbjct: 235 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----------IRILDELVLPFQELQIDDN 284
Query: 510 EYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPAL 569
EYAYLKAI+ F PD GL+ +I++ + + Q+ L+DY+ + R +L+ LP L
Sbjct: 285 EYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 344
Query: 570 RLMSSNITEELFFTGLIGNVSIDSIIPYIL 599
+ ++ + E++ F L G ID+++ +L
Sbjct: 345 QSITWQMIEQIQFIKLFGMAKIDNLLQEML 374
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 122 bits (307), Expect = 7e-28
Identities = 51/109 (46%), Positives = 76/109 (69%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD+A+G+HYGA SC+GCKGFF+RSVRKN YSCR ++ C+++K RN+C++CRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATP 244
C GMK E+VQ+ER +R + + + ++ ++ S I +P
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSP 146
Score = 91.7 bits (226), Expect = 2e-18
Identities = 68/270 (25%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query: 333 DTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTM 392
D ++ ++ + SS PS+ + V+SR ++P+ + G + +
Sbjct: 113 DRISTRRSSYEDSSLPSINALLQAE------VLSRQITSPVSGINGDIRAK--------- 157
Query: 393 PSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ 452
+ ++ +CES L + + WA+ IPAF L D +L+RA E LG +
Sbjct: 158 -----KIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 212
Query: 453 CAQVMSLSTILA---AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGY 509
+ V +L + H + ++S I L E +L ID
Sbjct: 213 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----------IRILDELVLPFQELQIDDN 262
Query: 510 EYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPAL 569
EYAYLKAI+ F PD GL+ +I++ + + Q+ L+DY+ + R +L+ LP L
Sbjct: 263 EYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 322
Query: 570 RLMSSNITEELFFTGLIGNVSIDSIIPYIL 599
+ ++ + E++ F L G ID+++ +L
Sbjct: 323 QSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 122 bits (307), Expect = 7e-28
Identities = 51/109 (46%), Positives = 76/109 (69%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD+A+G+HYGA SC+GCKGFF+RSVRKN YSCR ++ C+++K RN+C++CRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATP 244
C GMK E+VQ+ER +R + + + ++ ++ S I +P
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSP 146
Score = 91.7 bits (226), Expect = 2e-18
Identities = 68/270 (25%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query: 333 DTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTM 392
D ++ ++ + SS PS+ + V+SR ++P+ + G + +
Sbjct: 113 DRISTRRSSYEDSSLPSINALLQAE------VLSRQITSPVSGINGDIRAK--------- 157
Query: 393 PSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ 452
+ ++ +CES L + + WA+ IPAF L D +L+RA E LG +
Sbjct: 158 -----KIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 212
Query: 453 CAQVMSLSTILA---AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGY 509
+ V +L + H + ++S I L E +L ID
Sbjct: 213 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----------IRILDELVLPFQELQIDDN 262
Query: 510 EYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPAL 569
EYAYLKAI+ F PD GL+ +I++ + + Q+ L+DY+ + R +L+ LP L
Sbjct: 263 EYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 322
Query: 570 RLMSSNITEELFFTGLIGNVSIDSIIPYIL 599
+ ++ + E++ F L G ID+++ +L
Sbjct: 323 QSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 122 bits (307), Expect = 7e-28
Identities = 51/109 (46%), Positives = 76/109 (69%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGD+A+G+HYGA SC+GCKGFF+RSVRKN YSCR ++ C+++K RN+C++CRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATP 244
C GMK E+VQ+ER +R + + + ++ ++ S I +P
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSP 146
Score = 91.7 bits (226), Expect = 2e-18
Identities = 68/270 (25%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query: 333 DTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTM 392
D ++ ++ + SS PS+ + V+SR ++P+ + G + +
Sbjct: 113 DRISTRRSSYEDSSLPSINALLQAE------VLSRQITSPVSGINGDIRAK--------- 157
Query: 393 PSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQ 452
+ ++ +CES L + + WA+ IPAF L D +L+RA E LG +
Sbjct: 158 -----KIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 212
Query: 453 CAQVMSLSTILA---AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGY 509
+ V +L + H + ++S I L E +L ID
Sbjct: 213 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----------IRILDELVLPFQELQIDDN 262
Query: 510 EYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPAL 569
EYAYLKAI+ F PD GL+ +I++ + + Q+ L+DY+ + R +L+ LP L
Sbjct: 263 EYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 322
Query: 570 RLMSSNITEELFFTGLIGNVSIDSIIPYIL 599
+ ++ + E++ F L G ID+++ +L
Sbjct: 323 QSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 122 bits (307), Expect = 7e-28
Identities = 62/147 (42%), Positives = 88/147 (59%), Gaps = 17/147 (11%)
Query: 64 GSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLG 123
GSP F + SP G G+ L S + + T+S+ +VP
Sbjct: 35 GSPP--FEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPS---------------S 77
Query: 124 KTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKH 183
+ P+V + C VC DK+SG HYG SCEGCKGFF+RS++KN+ Y+C +++CIINK
Sbjct: 78 PSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKV 137
Query: 184 HRNRCQFCRLKKCLEMGMKMESVQSER 210
RNRCQ+CRL+KC E+GM E+V+++R
Sbjct: 138 TRNRCQYCRLQKCFEVGMSKEAVRNDR 164
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 122 bits (305), Expect = 1e-27
Identities = 61/144 (42%), Positives = 88/144 (61%), Gaps = 3/144 (2%)
Query: 85 LASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGK--TDVQRPQVVEYCVVCGDK 142
L+ P + Q S P I T S+S E ++ + P++ + C VC DK
Sbjct: 35 LSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDK 94
Query: 143 ASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMK 202
+SG HYG +CEGCKGFF+RS++KN+ Y+C +++CIINK RNRCQ+CRL+KC E+GM
Sbjct: 95 SSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMS 154
Query: 203 MESVQSERKPFDVQREKPSNCAAS 226
ESV+++R + KP C+ S
Sbjct: 155 KESVRNDRNKKKKEVPKP-ECSES 177
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 122 bits (305), Expect = 1e-27
Identities = 61/144 (42%), Positives = 88/144 (61%), Gaps = 3/144 (2%)
Query: 85 LASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGK--TDVQRPQVVEYCVVCGDK 142
L+ P + Q S P I T S+S E ++ + P++ + C VC DK
Sbjct: 35 LSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDK 94
Query: 143 ASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMK 202
+SG HYG +CEGCKGFF+RS++KN+ Y+C +++CIINK RNRCQ+CRL+KC E+GM
Sbjct: 95 SSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMS 154
Query: 203 MESVQSERKPFDVQREKPSNCAAS 226
ESV+++R + KP C+ S
Sbjct: 155 KESVRNDRNKKKKEVPKP-ECSES 177
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 122 bits (305), Expect = 1e-27
Identities = 71/203 (34%), Positives = 107/203 (52%), Gaps = 13/203 (6%)
Query: 405 ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILA 464
+CESA+RLLF+S+ WA+S+PAF L L+ W ELF LG+AQ A + +T+LA
Sbjct: 185 VCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLA 244
Query: 465 AIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFS--P 522
+ + D ++ +++ I LQE +L +D E+A LK IV F P
Sbjct: 245 V------SGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVP 298
Query: 523 DHPG-----LTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNIT 577
H G + + I Q++AQ+ L Y+ Y R ++L+ LPALR +S +
Sbjct: 299 THSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTI 358
Query: 578 EELFFTGLIGNVSIDSIIPYILK 600
EE+FF IGNV I ++ + K
Sbjct: 359 EEVFFKKTIGNVPITRLLSDMYK 381
Score = 108 bits (270), Expect = 1e-23
Identities = 45/79 (56%), Positives = 60/79 (75%), Gaps = 2/79 (2%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQD--CIINKHHRNRCQFCRL 193
C VCGD++SG+HYG +C+GC GFFKRS+R+N TY C+S C ++K HRN+C+ CRL
Sbjct: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
Query: 194 KKCLEMGMKMESVQSERKP 212
KKCLE+ M ++VQ ER P
Sbjct: 76 KKCLEVNMNKDAVQHERGP 94
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 120 bits (300), Expect = 5e-27
Identities = 57/120 (47%), Positives = 80/120 (66%), Gaps = 3/120 (2%)
Query: 111 IVTDSASVERLLGK--TDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNL 168
I T S S E L+ + + P+V + C VC DK+SG HYG +CEGCKGFF+RS++KN+
Sbjct: 54 IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 113
Query: 169 TYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTE 228
Y+C +++C+INK RNRCQ+CRL+KC E+GM ESV+++R + K C S E
Sbjct: 114 IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSK-QECTESYE 172
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 119 bits (299), Expect = 6e-27
Identities = 56/118 (47%), Positives = 81/118 (68%), Gaps = 3/118 (2%)
Query: 111 IVTDSASVERLLGK--TDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNL 168
I T S+S E ++ + P++ + C VC DK+SG HYG +CEGCKGFF+RS++KN+
Sbjct: 56 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 115
Query: 169 TYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAAS 226
Y+C +++CIINK RNRCQ+CRL+KC E+GM ESV+++R + KP C+ S
Sbjct: 116 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKP-ECSES 172
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 119 bits (299), Expect = 6e-27
Identities = 55/108 (50%), Positives = 77/108 (71%), Gaps = 3/108 (2%)
Query: 106 PGRIQIV-TDSASVERLL--GKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKR 162
P +Q V T S S E ++ + P+V + C VC DK+SG HYG SCEGCKGFF+R
Sbjct: 46 PASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRR 105
Query: 163 SVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSER 210
S++KN+ Y+C +++CIINK RNRCQ+CRL+KC E+GM E+V+++R
Sbjct: 106 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR 153
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 118 bits (295), Expect = 2e-26
Identities = 51/105 (48%), Positives = 75/105 (71%), Gaps = 3/105 (2%)
Query: 113 TDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSC 172
+DS++ E + TD V C +CGD+A+G+HYGA SC+GCKGFF+RS+RK+ YSC
Sbjct: 29 SDSSAPETSMNTTD---NGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSC 85
Query: 173 RSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQR 217
R ++ C+++K RN+C++CRL+KC GMK E+VQ+ER +R
Sbjct: 86 RFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRR 130
Score = 87.4 bits (215), Expect = 3e-17
Identities = 61/197 (30%), Positives = 100/197 (50%), Gaps = 12/197 (6%)
Query: 405 ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILA 464
+CES + L + + WA+ IPAF L D +L+RA E LG + + M IL
Sbjct: 176 VCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK--RSMMYKDILL 233
Query: 465 AIVNHL--QNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSP 522
N++ +NS + + I +V + L E ++ ID EYA LKAIV F P
Sbjct: 234 LGNNYVIHRNSCEVE------ISRVANRV--LDELVRPFQEIQIDDNEYACLKAIVFFDP 285
Query: 523 DHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFF 582
D GL+ +I+ + + Q+ L+DY+ + R +L+ LP L+ ++ + E++ F
Sbjct: 286 DAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQF 345
Query: 583 TGLIGNVSIDSIIPYIL 599
L G V ID+++ +L
Sbjct: 346 VKLFGMVKIDNLLQEML 362
>gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens]
Length = 518
Score = 112 bits (281), Expect = 8e-25
Identities = 126/500 (25%), Positives = 211/500 (42%), Gaps = 39/500 (7%)
Query: 124 KTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKH 183
KT + +V+ C +CGDK+SG HYG ++CEGCKGFF+RS R N YSC Q+C I++
Sbjct: 20 KTHTSQIEVIP-CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRT 78
Query: 184 HRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIR-KDLRSPLIA 242
RNRCQ CRL+KCL +GM ++V+ R ++++ S A +++ R + + P++
Sbjct: 79 SRNRCQHCRLQKCLALGMSRDAVKFGRMS---KKQRDSLHAEVQKQLQQRQQQQQEPVVK 135
Query: 243 TPTFVAD-KDGARQTGLLDPGMLVNIQQPLIREDGT----VLLATDSKAETSQGALGTLA 297
TP A D T L G L P + E +L A+ S S A
Sbjct: 136 TPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNL--AKA 193
Query: 298 NVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTS 357
+ + +L S G + + S++T D L G D+
Sbjct: 194 GLNGASCHLEYSPERGKAEGRESFYSTGSQLTP--DRCGLRFEEHRHPGLGELGQGPDSY 251
Query: 358 GGGSIHVISRDQSTPIIEVEGPLLS---DTHVTFKLTMPSPMPEYLNVHYICESASRLLF 414
G S + E+E + S T +L + + + N+ + E +
Sbjct: 252 GSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNI-FSREEVTGYQR 310
Query: 415 LSM--HWARS----IPAFQALGQDCN--TSLVRACWNELFTLGLAQCAQVMSLSTILAAI 466
SM W R A Q + + + + C N+ L A +V+ + A
Sbjct: 311 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 370
Query: 467 VNHLQNSIQEDKLSGDRIKQVM---EHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPD 523
++ + E K G + + + E I + +F +S++ L E A A+VL +
Sbjct: 371 ADN-RTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 429
Query: 524 HPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLP---ALRLMSSNITEEL 580
PGL ++E+ Q ++ ++ KT+ + IL +LP LR + S E L
Sbjct: 430 RPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS------ILAKLPPKGKLRSLCSQHVERL 483
Query: 581 FFTGLIGNVSIDSIIPYILK 600
+ + + + P + K
Sbjct: 484 QIFQHLHPIVVQAAFPPLYK 503
>gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens]
Length = 497
Score = 111 bits (278), Expect = 2e-24
Identities = 123/488 (25%), Positives = 205/488 (42%), Gaps = 38/488 (7%)
Query: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
C +CGDK+SG HYG ++CEGCKGFF+RS R N YSC Q+C I++ RNRCQ CRL+K
Sbjct: 10 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 69
Query: 196 CLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIR-KDLRSPLIATPTFVAD-KDGA 253
CL +GM ++V+ R ++++ S A +++ R + + P++ TP A D
Sbjct: 70 CLALGMSRDAVKFGRMS---KKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTL 126
Query: 254 RQTGLLDPGMLVNIQQPLIREDGT----VLLATDSKAETSQGALGTLANVVTSLANLSES 309
T L G L P + E +L A+ S S A + + +L S
Sbjct: 127 TYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNL--AKAGLNGASCHLEYS 184
Query: 310 LNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQ 369
G + + S++T D L G D+ G S
Sbjct: 185 PERGKAEGRESFYSTGSQLTP--DRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAP 242
Query: 370 STPIIEVEGPLLS---DTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSM--HWARS-- 422
+ E+E + S T +L + + + N+ + E + SM W R
Sbjct: 243 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNI-FSREEVTGYQRKSMWEMWERCAH 301
Query: 423 --IPAFQALGQDCN--TSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDK 478
A Q + + + + C N+ L A +V+ + A ++ + E K
Sbjct: 302 HLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADN-RTVFFEGK 360
Query: 479 LSGDRIKQVM---EHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEK 535
G + + + E I + +F +S++ L E A A+VL + PGL ++E+
Sbjct: 361 YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ 420
Query: 536 FQEKAQMELQDYVQKTYSEDTYRLARILVRLP---ALRLMSSNITEELFFTGLIGNVSID 592
Q ++ ++ KT+ + IL +LP LR + S E L + + +
Sbjct: 421 LQYNLELAFHHHLCKTHRQS------ILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQ 474
Query: 593 SIIPYILK 600
+ P + K
Sbjct: 475 AAFPPLYK 482
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,181,474
Number of Sequences: 37866
Number of extensions: 976911
Number of successful extensions: 3216
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 2808
Number of HSP's gapped (non-prelim): 353
length of query: 615
length of database: 18,247,518
effective HSP length: 108
effective length of query: 507
effective length of database: 14,157,990
effective search space: 7178100930
effective search space used: 7178100930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.