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Search of human proteins with 34996489
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34996489 pleckstrin homology domain interacting protein
[Homo sapiens]
(1821 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34996489 pleckstrin homology domain interacting protein [Homo... 3690 0.0
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo... 1882 0.0
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 1826 0.0
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 1826 0.0
gi|55956930 bromodomain and WD repeat domain containing 1 isofor... 140 9e-33
gi|32189425 WD repeat domain 69 [Homo sapiens] 125 3e-28
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 100 1e-20
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 100 1e-20
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 100 1e-20
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 100 1e-20
gi|23199987 WD repeat domain 5B [Homo sapiens] 96 2e-19
gi|21071067 TBP-associated factor 5 [Homo sapiens] 96 3e-19
gi|16554629 WD repeat domain 5 [Homo sapiens] 94 1e-18
gi|16554627 WD repeat domain 5 [Homo sapiens] 94 1e-18
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 90 2e-17
gi|157266266 WD repeat domain 86 [Homo sapiens] 90 2e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 89 4e-17
gi|26665869 WD repeat domain 51B [Homo sapiens] 89 4e-17
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 89 5e-17
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 84 1e-15
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 84 1e-15
gi|119943102 CREB binding protein isoform b [Homo sapiens] 84 2e-15
gi|119943104 CREB binding protein isoform a [Homo sapiens] 84 2e-15
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 83 3e-15
gi|19913369 transducin beta-like 3 [Homo sapiens] 83 3e-15
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 80 1e-14
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 79 4e-14
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 79 4e-14
gi|19913367 transducin beta-like 1Y [Homo sapiens] 79 4e-14
gi|19913365 transducin beta-like 1Y [Homo sapiens] 79 4e-14
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 3690 bits (9570), Expect = 0.0
Identities = 1821/1821 (100%), Positives = 1821/1821 (100%)
Query: 1 MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTY 60
MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTY
Sbjct: 1 MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTY 60
Query: 61 QNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVW 120
QNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVW
Sbjct: 61 QNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVW 120
Query: 121 KGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRIL 180
KGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRIL
Sbjct: 121 KGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRIL 180
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMI 240
GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMI
Sbjct: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMI 240
Query: 241 AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLW 300
AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLW
Sbjct: 241 AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLW 300
Query: 301 DAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE 360
DAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE
Sbjct: 301 DAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE 360
Query: 361 LEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIED 420
LEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIED
Sbjct: 361 LEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIED 420
Query: 421 KITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPR 480
KITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPR
Sbjct: 421 KITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPR 480
Query: 481 VLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLI 540
VLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLI
Sbjct: 481 VLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLI 540
Query: 541 FGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPS 600
FGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPS
Sbjct: 541 FGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPS 600
Query: 601 RYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSG 660
RYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSG
Sbjct: 601 RYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSG 660
Query: 661 EAGISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWS 720
EAGISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWS
Sbjct: 661 EAGISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWS 720
Query: 721 RRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHF 780
RRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHF
Sbjct: 721 RRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHF 780
Query: 781 LDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWH 840
LDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWH
Sbjct: 781 LDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWH 840
Query: 841 SDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKK 900
SDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKK
Sbjct: 841 SDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKK 900
Query: 901 KVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQM 960
KVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQM
Sbjct: 901 KVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQM 960
Query: 961 GDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCC 1020
GDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCC
Sbjct: 961 GDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCC 1020
Query: 1021 LKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAW 1080
LKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAW
Sbjct: 1021 LKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAW 1080
Query: 1081 WFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLT 1140
WFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLT
Sbjct: 1081 WFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLT 1140
Query: 1141 DGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVV 1200
DGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVV
Sbjct: 1141 DGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVV 1200
Query: 1201 AYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFI 1260
AYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFI
Sbjct: 1201 AYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFI 1260
Query: 1261 KDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQA 1320
KDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQA
Sbjct: 1261 KDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQA 1320
Query: 1321 WKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPME 1380
WKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPME
Sbjct: 1321 WKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPME 1380
Query: 1381 LCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKR 1440
LCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKR
Sbjct: 1381 LCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKR 1440
Query: 1441 RKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTES 1500
RKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTES
Sbjct: 1441 RKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTES 1500
Query: 1501 SSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHSKALNTLSS 1560
SSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHSKALNTLSS
Sbjct: 1501 SSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHSKALNTLSS 1560
Query: 1561 PGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPG 1620
PGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPG
Sbjct: 1561 PGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPG 1620
Query: 1621 TIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH 1680
TIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH
Sbjct: 1621 TIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH 1680
Query: 1681 PIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRR 1740
PIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRR
Sbjct: 1681 PIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRR 1740
Query: 1741 SNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFG 1800
SNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFG
Sbjct: 1741 SNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFG 1800
Query: 1801 TSSRGRVRKLTEKAKANLIGW 1821
TSSRGRVRKLTEKAKANLIGW
Sbjct: 1801 TSSRGRVRKLTEKAKANLIGW 1821
>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
sapiens]
Length = 1802
Score = 1882 bits (4874), Expect = 0.0
Identities = 935/1524 (61%), Positives = 1149/1524 (75%), Gaps = 84/1524 (5%)
Query: 9 SELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYR 68
+++ +ELY+LIARFL+ GPC ++AQVL++E+ E +L+PRR DW GKEH R++++LV
Sbjct: 6 TQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANA 65
Query: 69 HLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAAL 128
H+ PD+LL+IC R+GPLL++EIPQSVPGVQTLLG GRQSLLR K CK +W GSA AAL
Sbjct: 66 HIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAAL 125
Query: 129 HCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYC 188
H GRPPE PVNY PP++ + +R+L G R + P++ YQH+KMHKRILGHLSSVYC
Sbjct: 126 HRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYC 185
Query: 189 VTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKM 248
V FDR+GRRIFTGSDDCLVKIWATDDGRLLATLRGH+AEISDMAVNYENT+IAAGSCDK+
Sbjct: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
Query: 249 IRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKIN 308
+RVWCLRTCAP+AVLQGHSASITS+QF P G+ RYL+STGADGTICFW W T+K
Sbjct: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFR 305
Query: 309 PRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKV 368
RP KFTER RPGVQ+ CSSFS+GGMF+ TGSTDH+IR+Y+ GS PEKI+ELE HTDKV
Sbjct: 306 DRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKV 365
Query: 369 DSIQFSNT--SNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMK 426
++QF N S RFVSGSRDGTARIWQ++++EWKSI+LDMAT+ G NL EDKITK+K
Sbjct: 366 VAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLK 425
Query: 427 VTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAG 486
VTMVAWDR+D TVITAVNN LKVWNS TGQL+H L GH+DEVFVLE HPFD R++ SAG
Sbjct: 426 VTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAG 485
Query: 487 HDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSS 546
HDGN+ +WDL RG KIR+YFNMIEGQGHGAVFDCK SPDG HFACTDSHGHLL+FGFG S
Sbjct: 486 HDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCS 545
Query: 547 SKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLV 606
Y+KI DQMFFH+DYRPLIRDANN+VLDEQTQQAPHLMPPPFLVDVDGNPHP+++QRLV
Sbjct: 546 KYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLV 605
Query: 607 PGRENCREEQLIPQMGVTSSG----LNQVLSQQAN-QEISPLDSMIQRLQQEQDLRRSGE 661
PGRENC++EQLIPQ+G ++G + QV+ QQ N Q+ S LD +I+ LQ+EQDLR E
Sbjct: 606 PGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINE 665
Query: 662 AGIS----NTSRLSRGSISSTS-EVHSPPNVGLRR-SGQIEGVRQMHSNAPRSEIATERD 715
+ N + G++ S + ++ S PN+ LRR S QIEGVRQMH+NAPRS++ATERD
Sbjct: 666 GDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERD 725
Query: 716 LVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNH 775
L+AWSRRVVV EL+ GV+ QEE RTAKG+ EI Y TV K+ K ++ +
Sbjct: 726 LMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLY---------TVEKKKKPSYTTQRN 776
Query: 776 AHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEE----IENGSSSSDEGEVVAVSGGT 831
+E + Q+ QH Y+TRS +E + S + E+ SSS+E E V S +
Sbjct: 777 DYEPSCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDAS 836
Query: 832 SEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQK 891
E+ W S+ SSSD SS+YSDWTADAGINLQPPK+ + T+K SSSDEE
Sbjct: 837 VEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKS--- 893
Query: 892 QKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIP 951
+ ++KKPK+ ++K+ G ++ G EEW WI DTIP
Sbjct: 894 ------------------LEERQKKPKQTRKKK--GGLVSIAGEPNEEWFAPQWILDTIP 933
Query: 952 RRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKY 1011
RR PFVPQMGDE+ YFRQGHEAYV RK+KIYS+N +KQPW+KM+LREQE +KIVGIKY
Sbjct: 934 RRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKY 993
Query: 1012 EVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDR 1071
EVG PTLCCLKLAFLDP +GK+TG SF++KYHDMPDVIDFLVL Q +++AK R W IGDR
Sbjct: 994 EVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDR 1053
Query: 1072 FRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPE 1131
FRS+IDDAWWFGT+ESQ+P Q EYPDS FQCY+V WDN + EKMSPWDME IP FP+
Sbjct: 1054 FRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPD 1113
Query: 1132 ELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQ 1191
E+G VP++ E +L+YKP +GEWG + RDEECER++ GIN L++LD AS F PVDL
Sbjct: 1114 EVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLS 1173
Query: 1192 AYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKF 1251
AYP+YCTVVAYPTDL+TI++RLENRFYRR+S+LMWEVRYIEHN RTFNEP SPIVK+AK
Sbjct: 1174 AYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKI 1233
Query: 1252 VTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEK------DADVPGTSTRKRKDHQP 1305
VTD+LL FI DQ+C +I+ YN +K + + ++ EE D+D PGTS+ ++
Sbjct: 1234 VTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRK----V 1289
Query: 1306 RRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYP-------------- 1351
+ R R ++ + AWKKQC+ELL+LI++ EDSEPFRQP DLL YP
Sbjct: 1290 KCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVV 1349
Query: 1352 -----------DYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKR 1400
DY+D+IDTP+DF+TV+ETLEAGNY SP+E KDVR IF+NSKAYT +K+
Sbjct: 1350 PERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKK 1409
Query: 1401 SRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPER 1460
SRIYSM LRLSA FE HI +++S+YKSA++ KR R++ R+ SSS+SSS A SP+
Sbjct: 1410 SRIYSMMLRLSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKG 1469
Query: 1461 KKRILKPQLKSESSTSAFSTPTRS 1484
K++ +K Q K++ +TS T S
Sbjct: 1470 KQKQMKLQPKNDQNTSVSHARTSS 1493
Score = 57.8 bits (138), Expect = 1e-07
Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 13/87 (14%)
Query: 1740 RSNRKKIDDPIDEEEEFEELKGSE----PHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDT 1795
R+ R +I D +EF+ + P ++TRNQGRRT YN+D + + +
Sbjct: 1722 RAKRARIAD-----DEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDND---NFVSTED 1773
Query: 1796 SLTFGTSSRGRVRKLTEKAK-ANLIGW 1821
L GTS GRVRK+TEKA+ ++L+GW
Sbjct: 1774 PLNLGTSRSGRVRKMTEKARVSHLMGW 1800
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 1826 bits (4729), Expect = 0.0
Identities = 941/1676 (56%), Positives = 1172/1676 (69%), Gaps = 89/1676 (5%)
Query: 2 SCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQ 61
S R+ + + SELYFLIAR+L GPC++AAQVL++E+ + +LLP+R DW G EH R+Y+
Sbjct: 5 SSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYE 64
Query: 62 NLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWK 121
LV +H+APDHLLQIC R+GP+L++EIP S+ V +LLGAGRQSLLRT K C+H VWK
Sbjct: 65 ELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWK 124
Query: 122 GSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILG 181
GSA AALH GRPPE PVNYGSPP++ + ++L G P +YQH+KMH+RILG
Sbjct: 125 GSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILG 184
Query: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241
HLS+VYCV FDRTG RIFTGSDDCLVKIW+T +GRLL+TLRGH+AEISDMAVNYENTMIA
Sbjct: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
Query: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301
AGSCDK+IRVWCLRTCAP+AVLQGH+ SITSLQFSP+ GS+RY+ STGADGT+CFW WD
Sbjct: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
Query: 302 AGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISEL 361
+LK +PRP KFTE+PRPGVQM+CSSFS GGMFLATGSTDH+IR+YF G PEKI+EL
Sbjct: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAEL 364
Query: 362 EFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDK 421
E HTDKVDSIQF N +RF+SGSRDGTARIW+F++ EW+SILLDMATR +G +L E++
Sbjct: 365 ESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEER 423
Query: 422 ITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRV 481
K KVTM+AW+++D+ V+TAVN+ LKVWNSYTGQL+H LMGH DEVFVLE HPFD R+
Sbjct: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
Query: 482 LFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIF 541
+ SAGHDG++ +WD+ +G K++ YFNMIEGQGHGAVFDCK S DGQHFACTDSHGHLLIF
Sbjct: 484 MLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIF 543
Query: 542 GFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSR 601
GFG S Y+KI DQMFFH+DYRPLIRD+NN+VLDEQTQQAPHLMPPPFLVDVDGNPHP++
Sbjct: 544 GFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK 603
Query: 602 YQRLVPGRENCREEQLIPQMG--VTSSG--LNQVLSQQANQ------EISPLDSMIQRLQ 651
YQRLVPGREN +E LIPQ+G TS G + Q++S Q N E S LD MI++LQ
Sbjct: 604 YQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQ 663
Query: 652 QEQDLRRSGE-----AGISNTSRLSRGSISSTS-EVHSPPNVGLRRSGQIEGVRQMHSNA 705
Q+QD R + G+SN R S ++ SPPN+GLRRSGQ+EGVRQMH NA
Sbjct: 664 QQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNA 723
Query: 706 PRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVP-K 764
PRS+IATERDL AW RRVVVPE+ G+ + E++R KGEEE Y KRK L + K
Sbjct: 724 PRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHK 783
Query: 765 ENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEV 824
+ + VS++ +Q+T + Y + R SSS
Sbjct: 784 SDSVVLVSQS-------------RQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETS 830
Query: 825 VAVSGGTSEEEERAWHSD-------GSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKA 877
S G+ EE W SD SSSD SS YSDWTADAGINLQPP + +
Sbjct: 831 CDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITR 890
Query: 878 ESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTL 937
SS E+E S + ++ K+K K+ KPK+ +R+ EL N L
Sbjct: 891 FCSSSEDEISTENLSPPKRRRKRK-----------KENKPKKENLRRMTPAELA-NMEHL 938
Query: 938 EEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKME 997
E+ P WITDT R+ PFVPQMGDEV YFRQGHEAY+E R+N IY +NP K+PW KM+
Sbjct: 939 YEFHPPVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMD 998
Query: 998 LREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQ 1057
LR+QEL+KIVGI+YEVG PTLCCLKLAF+DP TGKL SF+++YHDMPDVIDFLVLRQ
Sbjct: 999 LRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQF 1058
Query: 1058 FDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSP 1117
+D+A+ R W DRFRS+IDDAWWFGT+ SQEP Q +YPDS FQCY V WDN + EK+SP
Sbjct: 1059 YDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSP 1118
Query: 1118 WDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMT 1177
WDME IP+N PEELG S+ +T E L+YKP GEWG RDEEC+RI++GI+QL+
Sbjct: 1119 WDMEPIPDNVDPPEELGASISVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLN 1178
Query: 1178 LDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRT 1237
LDIA+AF PVDL YP YCTVVAYPTDL TI+ RL NRFYRR+S+L+WEVRYIEHN RT
Sbjct: 1179 LDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNART 1238
Query: 1238 FNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTST 1297
FNEP S I +SAK +TD LL FIK+Q C NI L N+ + + ++ D+D+P TS+
Sbjct: 1239 FNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSEND--EQNAEDLDDSDLPKTSS 1296
Query: 1298 RKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDII 1357
+R+ H ++ + RA +Y WKKQC+EL+NLIFQCEDSEPFRQPVDL+EYPDYRDII
Sbjct: 1297 GRRRVHDGKKSI--RATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDII 1354
Query: 1358 DTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEH 1417
DTPMDF TVRETL+AGNY+SP+E CKD+RLIFSN+KAYTP+KRS+IYSM+LRLSA FEE
Sbjct: 1355 DTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEK 1414
Query: 1418 ISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKP-QLKSESS-- 1474
+ + SD+K +F+++ ++R K+R + S P + R LKP +LKS++
Sbjct: 1415 MKKISSDFKIGQKFNEKLRRSQRFKQRQ-----NCKGDSQPNKSIRNLKPKRLKSQTKII 1469
Query: 1475 TSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKA 1534
+PT+S R ++ + T + VT S+ SA + K
Sbjct: 1470 PELVGSPTQSTSSR------------TAYLGTHKTSAGISSGVTSGDSSDSAESSERRKR 1517
Query: 1535 NASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKEN-------------MEK 1581
N G T+ E+ V+ S A +LSS SS ++ A+E+ + +
Sbjct: 1518 NRPITNGSTLSESEVEDSLA-TSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTR 1576
Query: 1582 EKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKR 1637
+ +RK L + + D NN+L G I + G K++++
Sbjct: 1577 TRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEI-LKARAGNNRKVLRK 1631
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/276 (23%), Positives = 112/276 (40%), Gaps = 28/276 (10%)
Query: 1538 AIPGKTILENSVKHSKALN-TLSSPGQSSFSHGTRNNSAKENMEK-EKPVKRKMKS---- 1591
A GK +S +K L+ L+ S + + N+ K + P KRK S
Sbjct: 1993 ACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSS 2052
Query: 1592 -----SVLPKAST---LSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKP 1643
S +P + T S S + ++ +NN V + G+ + + P K
Sbjct: 2053 GEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKT 2112
Query: 1644 KVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVH----PIRDEVLPSSTCNFLSETN 1699
KV ++ KR R +L+ K + N+ + L S T + + T+
Sbjct: 2113 KVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTD 2172
Query: 1700 NVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRRSNRKKIDDPIDEEEEFEEL 1759
N K ++K +G K RK KT + + +V+ R+S R ++ ++ E+ +
Sbjct: 2173 NTKTK--RRKTKGKAKVVRKGKTFTAN----ISKTVRRQRQSKRPRLSVDDNDWEDLDYA 2226
Query: 1760 KGSE----PHMRTRNQGRRTAFYNEDDSEEEQRQLL 1791
K ++TRNQGRRT Y++ D + +L
Sbjct: 2227 KSKRVLRRSKIKTRNQGRRTVRYHDGDDDRSLENVL 2262
Score = 32.7 bits (73), Expect = 3.3
Identities = 31/159 (19%), Positives = 69/159 (43%), Gaps = 17/159 (10%)
Query: 785 ESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGS 844
+S+ ++H +R + + + PS+ + +SS E + G E +R + S+ +
Sbjct: 2019 DSEDMLNSEHKHR-HTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGS---ETDRTFSSEST 2074
Query: 845 SSDYSSDYSDWTADA--------GINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIK 896
+ ++ +++ + G L+ K P +KTK S + E+ K+K+ +
Sbjct: 2075 LAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPE 2134
Query: 897 KEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGL 935
E K++E + K + K +G +TE+ +
Sbjct: 2135 LENVKISE-----TTGNSKFRPDTSSKSSDLGSVTESDI 2168
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 1826 bits (4729), Expect = 0.0
Identities = 941/1676 (56%), Positives = 1172/1676 (69%), Gaps = 89/1676 (5%)
Query: 2 SCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQ 61
S R+ + + SELYFLIAR+L GPC++AAQVL++E+ + +LLP+R DW G EH R+Y+
Sbjct: 5 SSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYE 64
Query: 62 NLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWK 121
LV +H+APDHLLQIC R+GP+L++EIP S+ V +LLGAGRQSLLRT K C+H VWK
Sbjct: 65 ELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWK 124
Query: 122 GSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILG 181
GSA AALH GRPPE PVNYGSPP++ + ++L G P +YQH+KMH+RILG
Sbjct: 125 GSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILG 184
Query: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241
HLS+VYCV FDRTG RIFTGSDDCLVKIW+T +GRLL+TLRGH+AEISDMAVNYENTMIA
Sbjct: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
Query: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301
AGSCDK+IRVWCLRTCAP+AVLQGH+ SITSLQFSP+ GS+RY+ STGADGT+CFW WD
Sbjct: 245 AGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWD 304
Query: 302 AGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISEL 361
+LK +PRP KFTE+PRPGVQM+CSSFS GGMFLATGSTDH+IR+YF G PEKI+EL
Sbjct: 305 LESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAEL 364
Query: 362 EFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDK 421
E HTDKVDSIQF N +RF+SGSRDGTARIW+F++ EW+SILLDMATR +G +L E++
Sbjct: 365 ESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISG-DLSSEEER 423
Query: 422 ITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRV 481
K KVTM+AW+++D+ V+TAVN+ LKVWNSYTGQL+H LMGH DEVFVLE HPFD R+
Sbjct: 424 FMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRI 483
Query: 482 LFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIF 541
+ SAGHDG++ +WD+ +G K++ YFNMIEGQGHGAVFDCK S DGQHFACTDSHGHLLIF
Sbjct: 484 MLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIF 543
Query: 542 GFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSR 601
GFG S Y+KI DQMFFH+DYRPLIRD+NN+VLDEQTQQAPHLMPPPFLVDVDGNPHP++
Sbjct: 544 GFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTK 603
Query: 602 YQRLVPGRENCREEQLIPQMG--VTSSG--LNQVLSQQANQ------EISPLDSMIQRLQ 651
YQRLVPGREN +E LIPQ+G TS G + Q++S Q N E S LD MI++LQ
Sbjct: 604 YQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQ 663
Query: 652 QEQDLRRSGE-----AGISNTSRLSRGSISSTS-EVHSPPNVGLRRSGQIEGVRQMHSNA 705
Q+QD R + G+SN R S ++ SPPN+GLRRSGQ+EGVRQMH NA
Sbjct: 664 QQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNA 723
Query: 706 PRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVP-K 764
PRS+IATERDL AW RRVVVPE+ G+ + E++R KGEEE Y KRK L + K
Sbjct: 724 PRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHK 783
Query: 765 ENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEV 824
+ + VS++ +Q+T + Y + R SSS
Sbjct: 784 SDSVVLVSQS-------------RQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETS 830
Query: 825 VAVSGGTSEEEERAWHSD-------GSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKA 877
S G+ EE W SD SSSD SS YSDWTADAGINLQPP + +
Sbjct: 831 CDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITR 890
Query: 878 ESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTL 937
SS E+E S + ++ K+K K+ KPK+ +R+ EL N L
Sbjct: 891 FCSSSEDEISTENLSPPKRRRKRK-----------KENKPKKENLRRMTPAELA-NMEHL 938
Query: 938 EEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKME 997
E+ P WITDT R+ PFVPQMGDEV YFRQGHEAY+E R+N IY +NP K+PW KM+
Sbjct: 939 YEFHPPVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMD 998
Query: 998 LREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQ 1057
LR+QEL+KIVGI+YEVG PTLCCLKLAF+DP TGKL SF+++YHDMPDVIDFLVLRQ
Sbjct: 999 LRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQF 1058
Query: 1058 FDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSP 1117
+D+A+ R W DRFRS+IDDAWWFGT+ SQEP Q +YPDS FQCY V WDN + EK+SP
Sbjct: 1059 YDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSP 1118
Query: 1118 WDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMT 1177
WDME IP+N PEELG S+ +T E L+YKP GEWG RDEEC+RI++GI+QL+
Sbjct: 1119 WDMEPIPDNVDPPEELGASISVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLN 1178
Query: 1178 LDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRT 1237
LDIA+AF PVDL YP YCTVVAYPTDL TI+ RL NRFYRR+S+L+WEVRYIEHN RT
Sbjct: 1179 LDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNART 1238
Query: 1238 FNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTST 1297
FNEP S I +SAK +TD LL FIK+Q C NI L N+ + + ++ D+D+P TS+
Sbjct: 1239 FNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSEND--EQNAEDLDDSDLPKTSS 1296
Query: 1298 RKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDII 1357
+R+ H ++ + RA +Y WKKQC+EL+NLIFQCEDSEPFRQPVDL+EYPDYRDII
Sbjct: 1297 GRRRVHDGKKSI--RATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDII 1354
Query: 1358 DTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEH 1417
DTPMDF TVRETL+AGNY+SP+E CKD+RLIFSN+KAYTP+KRS+IYSM+LRLSA FEE
Sbjct: 1355 DTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEK 1414
Query: 1418 ISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKP-QLKSESS-- 1474
+ + SD+K +F+++ ++R K+R + S P + R LKP +LKS++
Sbjct: 1415 MKKISSDFKIGQKFNEKLRRSQRFKQRQ-----NCKGDSQPNKSIRNLKPKRLKSQTKII 1469
Query: 1475 TSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKA 1534
+PT+S R ++ + T + VT S+ SA + K
Sbjct: 1470 PELVGSPTQSTSSR------------TAYLGTHKTSAGISSGVTSGDSSDSAESSERRKR 1517
Query: 1535 NASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKEN-------------MEK 1581
N G T+ E+ V+ S A +LSS SS ++ A+E+ + +
Sbjct: 1518 NRPITNGSTLSESEVEDSLA-TSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTR 1576
Query: 1582 EKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKR 1637
+ +RK L + + D NN+L G I + G K++++
Sbjct: 1577 TRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEI-LKARAGNNRKVLRK 1631
Score = 32.7 bits (73), Expect = 3.3
Identities = 31/159 (19%), Positives = 69/159 (43%), Gaps = 17/159 (10%)
Query: 785 ESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGS 844
+S+ ++H +R + + + PS+ + +SS E + G E +R + S+ +
Sbjct: 2019 DSEDMLNSEHKHR-HTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGS---ETDRTFSSEST 2074
Query: 845 SSDYSSDYSDWTADA--------GINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIK 896
+ ++ +++ + G L+ K P +KTK S + E+ K+K+ +
Sbjct: 2075 LAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPE 2134
Query: 897 KEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGL 935
E K++E + K + K +G +TE+ +
Sbjct: 2135 LENVKISE-----TTGNSKFRPDTSSKSSDLGSVTESDI 2168
>gi|55956930 bromodomain and WD repeat domain containing 1 isoform C
[Homo sapiens]
Length = 120
Score = 140 bits (354), Expect = 9e-33
Identities = 66/112 (58%), Positives = 88/112 (78%)
Query: 2 SCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQ 61
S R+ + + SELYFLIAR+L GPC++AAQVL++E+ + +LLP+R DW G EH R+Y+
Sbjct: 5 SSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYE 64
Query: 62 NLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNK 113
LV +H+APDHLLQIC R+GP+L++EIP S+ V +LLGAGRQSLLRT K
Sbjct: 65 ELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAK 116
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 125 bits (315), Expect = 3e-28
Identities = 90/315 (28%), Positives = 153/315 (48%), Gaps = 33/315 (10%)
Query: 181 GHLSSVYCVTFDRT-GRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTM 239
GH + VY + F+ G +I TGS D K+W+ + G+ T RGH AEI ++ N ++T+
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL 191
Query: 240 IAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWL 299
+A GS D ++W ++ + L+GHSA I SL F+ SG + + + D T+ W
Sbjct: 192 VATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN--TSGDR--IITGSFDHTVVVWD 247
Query: 300 WDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKIS 359
D G K+N E + +SF+ + TGS D +++ +G + ++
Sbjct: 248 ADTGR-KVNILIGHCAE-------ISSASFNWDCSLILTGSMDKTCKLWDATNG--KCVA 297
Query: 360 ELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIE 419
L H D++ F T + S DGTARI+ ATR L+G E
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIF------------SAATRKCIAKLEGHE 345
Query: 420 DKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDP 479
+I+K ++++ N ++T ++ T ++W++ TGQ + VL GH DE+F +
Sbjct: 346 GEISK-----ISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC-AFNYKG 399
Query: 480 RVLFSAGHDGNVIVW 494
++ + D +W
Sbjct: 400 NIVITGSKDNTCRIW 414
Score = 111 bits (277), Expect = 7e-24
Identities = 84/278 (30%), Positives = 125/278 (44%), Gaps = 31/278 (11%)
Query: 174 KMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAV 233
K + GH + + C++F+ + TGS D K+W +G + TLRGH+AEI ++
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 234 NYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADG 293
N I GS D + VW T + +L GH A I+S F+ CS L TG+
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS-----LILTGSMD 282
Query: 294 TICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSG 353
C LWDA K + +++ S F G +AT S D R+ F +
Sbjct: 283 KTC-KLWDATNGKCVATLTGHDD------EILDSCFDYTGKLIATASADGTARI--FSAA 333
Query: 354 QPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQ 413
+ I++LE H ++ I F+ N ++GS D TARIW D T Q
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW------------DAQTGQCLQ 381
Query: 414 NLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVW 451
L+G D+I A++ N VIT + T ++W
Sbjct: 382 VLEGHTDEIFS-----CAFNYKGNIVITGSKDNTCRIW 414
Score = 102 bits (255), Expect = 3e-21
Identities = 70/213 (32%), Positives = 109/213 (51%), Gaps = 14/213 (6%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMI 240
GH + + ++F+ +G RI TGS D V +W D GR + L GH AEIS + N++ ++I
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLI 276
Query: 241 AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLW 300
GS DK ++W +A L GH I F + + +++ ADGT ++
Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY----TGKLIATASADGTAR--IF 330
Query: 301 DAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE 360
A T K + E + I SF+ G L TGS+D R++ +GQ ++
Sbjct: 331 SAATRKCIAK----LEGHEGEISKI--SFNPQGNHLLTGSSDKTARIWDAQTGQCLQV-- 382
Query: 361 LEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ 393
LE HTD++ S F+ N ++GS+D T RIW+
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 55.1 bits (131), Expect = 6e-07
Identities = 41/176 (23%), Positives = 78/176 (44%), Gaps = 21/176 (11%)
Query: 328 SFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNT-SNRFVSGSRD 386
+ + G TGS D +++ SG E+++ LE H + V +I F+N ++ +GS D
Sbjct: 99 ALNKSGSCFITGSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 387 GTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNM 446
T ++W + T +G ++ ++++ V T +
Sbjct: 157 KTCKLWSVE------------TGKCYHTFRG-----HTAEIVCLSFNPQSTLVATGSMDT 199
Query: 447 TLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKI 502
T K+W+ G+ ++ L GH E+ L + R++ + D V+VWD G K+
Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKV 254
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 100 bits (249), Expect = 1e-20
Identities = 92/358 (25%), Positives = 156/358 (43%), Gaps = 56/358 (15%)
Query: 173 MKMHKRILGHLSSVY-CVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDM 231
+K K + GH V C+ F G RI +GSDD +K+W+ G+ L TL GH +
Sbjct: 252 LKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--W 307
Query: 232 AVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGA 291
+ + +I +GS D+ ++VW T + L GH++++ + KR +S +
Sbjct: 308 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH-----EKRVVSGS-R 361
Query: 292 DGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFG 351
D T+ W + G G G + +G+ D +++V+
Sbjct: 362 DATLRVWDIETGQCL----------HVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW--- 408
Query: 352 SGQPEK---ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMAT 408
PE + L+ HT++V S+QF VSGS D + R+W D+ T
Sbjct: 409 --DPETETCLHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVW------------DVET 452
Query: 409 RPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMG---H 465
L G + + M++ DN +++ + T+K+W+ TGQ + L G H
Sbjct: 453 GNCIHTLTGHQSLTSGMELK-------DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505
Query: 466 EDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCS 523
+ V L+ F+ + ++ DG V +WDL G IR+ + G G V+ + S
Sbjct: 506 QSAVTCLQ---FNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRAS 560
Score = 84.3 bits (207), Expect = 1e-15
Identities = 63/248 (25%), Positives = 111/248 (44%), Gaps = 23/248 (9%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENT 238
+ GH S+V C+ +R+ +GS D +++W + G+ L L GH A + V Y+
Sbjct: 339 LYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGR 394
Query: 239 MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW 298
+ +G+ D M++VW T L LQGH+ + SLQF + ++ S D +I W
Sbjct: 395 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI------HVVSGSLDTSIRVW 448
Query: 299 LWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP-EK 357
+ G G Q + S L +G+ D ++++ +GQ +
Sbjct: 449 DVETGNCI----------HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQT 498
Query: 358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQG 417
+ H V +QF+ N ++ S DGT ++W K E+ L+ + + +G +
Sbjct: 499 LQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR 556
Query: 418 IEDKITKM 425
I TK+
Sbjct: 557 IRASNTKL 564
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 100 bits (249), Expect = 1e-20
Identities = 92/358 (25%), Positives = 156/358 (43%), Gaps = 56/358 (15%)
Query: 173 MKMHKRILGHLSSVY-CVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDM 231
+K K + GH V C+ F G RI +GSDD +K+W+ G+ L TL GH +
Sbjct: 370 LKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--W 425
Query: 232 AVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGA 291
+ + +I +GS D+ ++VW T + L GH++++ + KR +S +
Sbjct: 426 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH-----EKRVVSGS-R 479
Query: 292 DGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFG 351
D T+ W + G G G + +G+ D +++V+
Sbjct: 480 DATLRVWDIETGQCL----------HVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW--- 526
Query: 352 SGQPEK---ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMAT 408
PE + L+ HT++V S+QF VSGS D + R+W D+ T
Sbjct: 527 --DPETETCLHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVW------------DVET 570
Query: 409 RPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMG---H 465
L G + + M++ DN +++ + T+K+W+ TGQ + L G H
Sbjct: 571 GNCIHTLTGHQSLTSGMELK-------DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623
Query: 466 EDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCS 523
+ V L+ F+ + ++ DG V +WDL G IR+ + G G V+ + S
Sbjct: 624 QSAVTCLQ---FNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRAS 678
Score = 84.3 bits (207), Expect = 1e-15
Identities = 63/248 (25%), Positives = 111/248 (44%), Gaps = 23/248 (9%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENT 238
+ GH S+V C+ +R+ +GS D +++W + G+ L L GH A + V Y+
Sbjct: 457 LYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGR 512
Query: 239 MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW 298
+ +G+ D M++VW T L LQGH+ + SLQF + ++ S D +I W
Sbjct: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI------HVVSGSLDTSIRVW 566
Query: 299 LWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP-EK 357
+ G G Q + S L +G+ D ++++ +GQ +
Sbjct: 567 DVETGNCI----------HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQT 616
Query: 358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQG 417
+ H V +QF+ N ++ S DGT ++W K E+ L+ + + +G +
Sbjct: 617 LQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR 674
Query: 418 IEDKITKM 425
I TK+
Sbjct: 675 IRASNTKL 682
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 100 bits (249), Expect = 1e-20
Identities = 92/358 (25%), Positives = 156/358 (43%), Gaps = 56/358 (15%)
Query: 173 MKMHKRILGHLSSVY-CVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDM 231
+K K + GH V C+ F G RI +GSDD +K+W+ G+ L TL GH +
Sbjct: 290 LKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--W 345
Query: 232 AVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGA 291
+ + +I +GS D+ ++VW T + L GH++++ + KR +S +
Sbjct: 346 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH-----EKRVVSGS-R 399
Query: 292 DGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFG 351
D T+ W + G G G + +G+ D +++V+
Sbjct: 400 DATLRVWDIETGQCL----------HVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW--- 446
Query: 352 SGQPEK---ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMAT 408
PE + L+ HT++V S+QF VSGS D + R+W D+ T
Sbjct: 447 --DPETETCLHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVW------------DVET 490
Query: 409 RPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMG---H 465
L G + + M++ DN +++ + T+K+W+ TGQ + L G H
Sbjct: 491 GNCIHTLTGHQSLTSGMELK-------DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543
Query: 466 EDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCS 523
+ V L+ F+ + ++ DG V +WDL G IR+ + G G V+ + S
Sbjct: 544 QSAVTCLQ---FNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRAS 598
Score = 84.3 bits (207), Expect = 1e-15
Identities = 63/248 (25%), Positives = 111/248 (44%), Gaps = 23/248 (9%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENT 238
+ GH S+V C+ +R+ +GS D +++W + G+ L L GH A + V Y+
Sbjct: 377 LYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGR 432
Query: 239 MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW 298
+ +G+ D M++VW T L LQGH+ + SLQF + ++ S D +I W
Sbjct: 433 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI------HVVSGSLDTSIRVW 486
Query: 299 LWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP-EK 357
+ G G Q + S L +G+ D ++++ +GQ +
Sbjct: 487 DVETGNCI----------HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQT 536
Query: 358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQG 417
+ H V +QF+ N ++ S DGT ++W K E+ L+ + + +G +
Sbjct: 537 LQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR 594
Query: 418 IEDKITKM 425
I TK+
Sbjct: 595 IRASNTKL 602
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 100 bits (249), Expect = 1e-20
Identities = 65/221 (29%), Positives = 103/221 (46%), Gaps = 15/221 (6%)
Query: 177 KRILGHLSSVYCVTFDR-TGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNY 235
+ I+ H S+V + + +GR + TG DDC V +W+ + + +L GH + + + +N
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT 73
Query: 236 ENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTI 295
+I AGS IRVW L L L GH A+I SL F P +++S D I
Sbjct: 74 PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY----GEFVASGSQDTNI 129
Query: 296 CFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP 355
W I + F R + C FS G +LA+ + DH ++++ +G
Sbjct: 130 KLW-------DIRRKGCVFRYRGH-SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG-- 179
Query: 356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKR 396
+ +SE HT V+ ++F SGS D T R W ++
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Score = 64.3 bits (155), Expect = 1e-09
Identities = 63/249 (25%), Positives = 108/249 (43%), Gaps = 38/249 (15%)
Query: 331 AGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTAR 390
A G LATG D RV + +P I L HT V+S++ + V+GS+ G+ R
Sbjct: 31 ASGRLLATGGDD--CRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIR 88
Query: 391 IWQFKRRE-------WKSILLDMATRPAGQNL-QGIEDKITKM-----KVTMVAWDRHDN 437
+W + + K+ + + P G+ + G +D K+ K + + H
Sbjct: 89 VWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148
Query: 438 TV------------ITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSA 485
V +A ++ T+K+W+ G+++ GH V V+E HP + +L S
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHP-NEYLLASG 207
Query: 486 GHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDG--QHFACTDSHGHLLIFGF 543
D + WDL + + + IEG+ G V +PDG + C DS L ++G+
Sbjct: 208 SSDRTIRFWDLEKFQVV----SCIEGE-PGPVRSVLFNPDGCCLYSGCQDS---LRVYGW 259
Query: 544 GSSSKYDKI 552
+D +
Sbjct: 260 EPERCFDVV 268
Score = 63.2 bits (152), Expect = 2e-09
Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 4/124 (3%)
Query: 178 RILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYEN 237
R GH +V C+ F G+ + + +DD VK+W G++++ GH ++ + +
Sbjct: 142 RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE 201
Query: 238 TMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSP----LCSGSKRYLSSTGADG 293
++A+GS D+ IR W L ++ ++G + S+ F+P L SG + L G +
Sbjct: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEP 261
Query: 294 TICF 297
CF
Sbjct: 262 ERCF 265
Score = 57.4 bits (137), Expect = 1e-07
Identities = 48/216 (22%), Positives = 95/216 (43%), Gaps = 18/216 (8%)
Query: 88 QEIPQSVPGVQTL-LGAGRQSLLRTN-KSCKHVVW---KGSALAALHCGRPPESPVNYGS 142
QEI V +L LG LL T C+ +W K + + +L P V +
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNT 73
Query: 143 PPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGS 202
P + + + +G R+ L + K+ + ++GH +++ + F G + +GS
Sbjct: 74 PEEL---IVAGSQSGSIRVWDL------EAAKILRTLMGHKANICSLDFHPYGEFVASGS 124
Query: 203 DDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAV 262
D +K+W + RGH+ + + + + +A+ + D +++W L ++
Sbjct: 125 QDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE 184
Query: 263 LQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW 298
GH+ + ++F P ++ L+S +D TI FW
Sbjct: 185 FPGHTGPVNVVEFHP----NEYLLASGSSDRTIRFW 216
Score = 49.7 bits (117), Expect = 3e-05
Identities = 42/182 (23%), Positives = 73/182 (40%), Gaps = 27/182 (14%)
Query: 357 KISELEFHTDKVDSIQFSNTSNRFVS-GSRDGTARIWQFKRREWKSILLDMATRPAGQNL 415
K+ E+ H V S+ S R ++ G D +W + + L T P
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNC-IMSLTGHTSP----- 65
Query: 416 QGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPH 475
V V + + ++ + +++VW+ +++ LMGH+ + L+ H
Sbjct: 66 -----------VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFH 114
Query: 476 PFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDC-KCSPDGQHFA-CTD 533
P+ V S D N+ +WD+ R + Y +GH C + SPDG+ A D
Sbjct: 115 PYGEFVA-SGSQDTNIKLWDIRRKGCVFRY------RGHSQAVRCLRFSPDGKWLASAAD 167
Query: 534 SH 535
H
Sbjct: 168 DH 169
Score = 31.6 bits (70), Expect = 7.4
Identities = 17/79 (21%), Positives = 34/79 (43%), Gaps = 1/79 (1%)
Query: 174 KMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAV 233
KM GH V V F + +GS D ++ W + ++++ + G + +
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLF 239
Query: 234 NYENTMIAAGSCDKMIRVW 252
N + + +G C +RV+
Sbjct: 240 NPDGCCLYSG-CQDSLRVY 257
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 96.3 bits (238), Expect = 2e-19
Identities = 77/321 (23%), Positives = 137/321 (42%), Gaps = 36/321 (11%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENT 238
++GH +V V F G + + S D L+ IW DG+ TL GH EISD+A + +++
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 239 MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW 298
+ + S DK +++W +R+ L L+GHS + F+P + S D T+ W
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP----PSNLIISGSFDETVKIW 152
Query: 299 LWDAG----TLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQ 354
G TL + P F+ G + +GS D + R++ SGQ
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVH------------FNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 355 PEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQN 414
K + ++ V ++FS ++ + D T ++W + R + T +N
Sbjct: 201 CLK-TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC------LKTYTGHKN 253
Query: 415 LQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEP 474
+ VT W +++ + + +WN T +++ L GH D V
Sbjct: 254 EKYCI--FANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC 305
Query: 475 HPFDPRVLFSA-GHDGNVIVW 494
HP + + +A +D + +W
Sbjct: 306 HPTENLIASAALENDKTIKLW 326
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/283 (25%), Positives = 127/283 (44%), Gaps = 31/283 (10%)
Query: 174 KMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAV 233
K K + GH + V + R+ + SDD +K+W G+ L TL+GH+ +
Sbjct: 74 KYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNF 133
Query: 234 NYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADG 293
N + +I +GS D+ +++W ++T L L HS ++++ F+ CSGS L +G+
Sbjct: 134 NPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN--CSGS---LIVSGSYD 188
Query: 294 TICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSG 353
+C +WDA + + P V + FS G ++ T + D+ ++++ + G
Sbjct: 189 GLC-RIWDAAS---GQCLKTLVDDDNPPVSFV--KFSPNGKYILTATLDNTLKLWDYSRG 242
Query: 354 QPEKISELEFHTDKVDSIQFSNTSNRF-VSGSRDGTARIWQFKRREWKSILLDMATRPAG 412
+ K + FS T ++ VSGS D IW ++ T+
Sbjct: 243 RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW------------NLQTKEIV 290
Query: 413 QNLQGIEDKITKMKVTMVAWDRHDNTVITAV--NNMTLKVWNS 453
Q LQG D V A +N + +A N+ T+K+W S
Sbjct: 291 QKLQGHTD-----VVISAACHPTENLIASAALENDKTIKLWMS 328
Score = 78.6 bits (192), Expect = 5e-14
Identities = 73/312 (23%), Positives = 132/312 (42%), Gaps = 41/312 (13%)
Query: 217 LLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFS 276
L TL GH +S + + +A+ S D++I +W L GH+ I+ + +S
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 277 PLCSGSKRYLSSTGADGTICFWLWDAGT-LKINPRPAKFTERPRPGVQMICSSFSAGGMF 335
S S R +S++ D T+ W +G LK + + + C +F+
Sbjct: 93 ---SDSSRLVSASD-DKTLKLWDVRSGKCLKTLKGHSNY---------VFCCNFNPPSNL 139
Query: 336 LATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFK 395
+ +GS D ++++ +G+ K L H+D V ++ F+ + + VSGS DG RIW
Sbjct: 140 IISGSFDETVKIWEVKTGKCLKT--LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 396 RREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYT 455
+ L+D P V+ V + + ++TA + TLK+W+
Sbjct: 198 SGQCLKTLVDDDNPP----------------VSFVKFSPNGKYILTATLDNTLKLWDYSR 241
Query: 456 GQLIHVLMGHEDEVFVLEPH--PFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQG 513
G+ + GH++E + + + + + S D V +W+L ++ QG
Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL------QG 295
Query: 514 H-GAVFDCKCSP 524
H V C P
Sbjct: 296 HTDVVISAACHP 307
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 95.9 bits (237), Expect = 3e-19
Identities = 66/233 (28%), Positives = 106/233 (45%), Gaps = 19/233 (8%)
Query: 161 LERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLAT 220
LER++ +K+ + GH VY +F + + S+D V++W+ L
Sbjct: 524 LERIMDEKTASELKI---LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580
Query: 221 LRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCS 280
+GH + D + +G D++ R+W PL + GH A + +F P
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP--- 637
Query: 281 GSKRYLSSTGADGTICFW-LWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATG 339
+ Y+++ AD T+ W + + ++I FT P + +FS G FLATG
Sbjct: 638 -NSNYVATGSADRTVRLWDVLNGNCVRI------FTGHKGP---IHSLTFSPNGRFLATG 687
Query: 340 STDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
+TD RV + G + EL+ HTD V S++FS SGS D T R+W
Sbjct: 688 ATDG--RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 67.0 bits (162), Expect = 2e-10
Identities = 68/314 (21%), Positives = 117/314 (37%), Gaps = 43/314 (13%)
Query: 201 GSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPL 260
G D V++W+ +L + + SD++ +I S D + R+ +T + L
Sbjct: 488 GFADSTVRVWSVTPKKLRSV-----KQASDLS------LIDKESDDVLERIMDEKTASEL 536
Query: 261 AVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRP 320
+L GHS + FSP + YL S+ DGT+ W T + + +
Sbjct: 537 KILYGHSGPVYGASFSP----DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY------ 586
Query: 321 GVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRF 380
+ + FS G + +G D + R++ QP +I H V+ +F SN
Sbjct: 587 --PVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI--FAGHLADVNCTRFHPNSNYV 642
Query: 381 VSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVI 440
+GS D T R+W I K + + + + +
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTG-----------------HKGPIHSLTFSPNGRFLA 685
Query: 441 TAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGV 500
T + + +W+ G ++ L GH D V L D +L S D V +WD +
Sbjct: 686 TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR-FSRDGEILASGSMDNTVRLWDAIKAF 744
Query: 501 KIRSYFNMIEGQGH 514
+ + GH
Sbjct: 745 EDLETDDFTTATGH 758
Score = 63.5 bits (153), Expect = 2e-09
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 9/146 (6%)
Query: 157 GKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGR 216
G R+ RL T YQ +++ GHL+ V C F + TGS D V++W +G
Sbjct: 604 GHDRVARLWATDHYQPLRI---FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 217 LLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFS 276
+ GH I + + +A G+ D + +W + + L+GH+ ++ SL+F
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRF- 719
Query: 277 PLCSGSKRYLSSTGADGTICFWLWDA 302
S L+S D T+ LWDA
Sbjct: 720 ---SRDGEILASGSMDNTV--RLWDA 740
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/193 (22%), Positives = 76/193 (39%), Gaps = 33/193 (17%)
Query: 364 HTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKR-------REWKSILLDMATRPAGQN-L 415
H+ V FS N +S S DGT R+W + + + D P G +
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
Query: 416 QGIEDKITKM-----------------KVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQL 458
G D++ ++ V + + N V T + T+++W+ G
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC 661
Query: 459 IHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGH-GAV 517
+ + GH+ + L P + R L + DG V++WD+ G+ + E +GH V
Sbjct: 662 VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLMVG------ELKGHTDTV 714
Query: 518 FDCKCSPDGQHFA 530
+ S DG+ A
Sbjct: 715 CSLRFSRDGEILA 727
Score = 35.8 bits (81), Expect = 0.39
Identities = 35/169 (20%), Positives = 66/169 (39%), Gaps = 39/169 (23%)
Query: 370 SIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTM 429
++ ++ S+ G D T R+W ++ +S+ K +
Sbjct: 475 AVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV---------------------KQASDL 513
Query: 430 VAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDG 489
D+ + V+ ++ + T + +L GH V+ P D L S+ DG
Sbjct: 514 SLIDKESDDVLE-------RIMDEKTASELKILYGHSGPVYGASFSP-DRNYLLSSSEDG 565
Query: 490 NVIVWDLARGVKIRSYFNMIEGQGHG-AVFDCKCSPDGQHFACTDSHGH 537
V +W L +++ ++ +GH V+D + SP G +F S GH
Sbjct: 566 TVRLWSL------QTFTCLVGYKGHNYPVWDTQFSPYGYYFV---SGGH 605
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 94.0 bits (232), Expect = 1e-18
Identities = 75/330 (22%), Positives = 141/330 (42%), Gaps = 28/330 (8%)
Query: 166 PTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHA 225
PT V + + + GH +V V F G + + S D L+KIW DG+ T+ GH
Sbjct: 28 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK 87
Query: 226 AEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRY 285
ISD+A + ++ ++ + S DK +++W + + L L+GHS + F+P
Sbjct: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP----QSNL 143
Query: 286 LSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHII 345
+ S D ++ +WD T K P + F+ G + + S D +
Sbjct: 144 IVSGSFDESV--RIWDVKTGKC------LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 346 RVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLD 405
R++ SGQ K + ++ V ++FS ++ + D T ++W + + +
Sbjct: 196 RIWDTASGQCLK-TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC------ 248
Query: 406 MATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGH 465
+ T +N + VT W +++ + + +WN T +++ L GH
Sbjct: 249 LKTYTGHKNEKYC--IFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 466 EDEVFVLEPHPFDPRVLFSA-GHDGNVIVW 494
D V HP + + +A +D + +W
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 80.5 bits (197), Expect = 1e-14
Identities = 61/229 (26%), Positives = 108/229 (47%), Gaps = 26/229 (11%)
Query: 174 KMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAV 233
K K + GH + V+C F+ I +GS D V+IW G+ L TL H+ +S +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 234 NYENTMIAAGSCDKMIRVW------CLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLS 287
N + ++I + S D + R+W CL+T ++ + ++ ++FSP + +Y+
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKT-----LIDDDNPPVSFVKFSP----NGKYIL 230
Query: 288 STGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSA-GGMFLATGSTDHIIR 346
+ D T+ W + G + K + I ++FS GG ++ +GS D++
Sbjct: 231 AATLDNTLKLWDYSKG------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL-- 282
Query: 347 VYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGS--RDGTARIWQ 393
VY + E + +L+ HTD V S T N S + D T ++W+
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 58.9 bits (141), Expect = 4e-08
Identities = 47/200 (23%), Positives = 94/200 (47%), Gaps = 24/200 (12%)
Query: 329 FSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGT 388
FS G +LA+ S D +I+++ G+ EK + H + + +S+ SN VS S D T
Sbjct: 53 FSPNGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWSSDSNLLVSASDDKT 110
Query: 389 ARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTL 448
+IW D+++ + L+G + V ++ N +++ + ++
Sbjct: 111 LKIW------------DVSSGKCLKTLKGHSNY-----VFCCNFNPQSNLIVSGSFDESV 153
Query: 449 KVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNM 508
++W+ TG+ + L H D V + + D ++ S+ +DG +WD A G +++ +
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLID- 211
Query: 509 IEGQGHGAVFDCKCSPDGQH 528
+ V K SP+G++
Sbjct: 212 ---DDNPPVSFVKFSPNGKY 228
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 94.0 bits (232), Expect = 1e-18
Identities = 75/330 (22%), Positives = 141/330 (42%), Gaps = 28/330 (8%)
Query: 166 PTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHA 225
PT V + + + GH +V V F G + + S D L+KIW DG+ T+ GH
Sbjct: 28 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK 87
Query: 226 AEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRY 285
ISD+A + ++ ++ + S DK +++W + + L L+GHS + F+P
Sbjct: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP----QSNL 143
Query: 286 LSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHII 345
+ S D ++ +WD T K P + F+ G + + S D +
Sbjct: 144 IVSGSFDESV--RIWDVKTGKC------LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 346 RVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLD 405
R++ SGQ K + ++ V ++FS ++ + D T ++W + + +
Sbjct: 196 RIWDTASGQCLK-TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC------ 248
Query: 406 MATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGH 465
+ T +N + VT W +++ + + +WN T +++ L GH
Sbjct: 249 LKTYTGHKNEKYC--IFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 466 EDEVFVLEPHPFDPRVLFSA-GHDGNVIVW 494
D V HP + + +A +D + +W
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 80.5 bits (197), Expect = 1e-14
Identities = 61/229 (26%), Positives = 108/229 (47%), Gaps = 26/229 (11%)
Query: 174 KMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAV 233
K K + GH + V+C F+ I +GS D V+IW G+ L TL H+ +S +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 234 NYENTMIAAGSCDKMIRVW------CLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLS 287
N + ++I + S D + R+W CL+T ++ + ++ ++FSP + +Y+
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKT-----LIDDDNPPVSFVKFSP----NGKYIL 230
Query: 288 STGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSA-GGMFLATGSTDHIIR 346
+ D T+ W + G + K + I ++FS GG ++ +GS D++
Sbjct: 231 AATLDNTLKLWDYSKG------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL-- 282
Query: 347 VYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGS--RDGTARIWQ 393
VY + E + +L+ HTD V S T N S + D T ++W+
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 58.9 bits (141), Expect = 4e-08
Identities = 47/200 (23%), Positives = 94/200 (47%), Gaps = 24/200 (12%)
Query: 329 FSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGT 388
FS G +LA+ S D +I+++ G+ EK + H + + +S+ SN VS S D T
Sbjct: 53 FSPNGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWSSDSNLLVSASDDKT 110
Query: 389 ARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTL 448
+IW D+++ + L+G + V ++ N +++ + ++
Sbjct: 111 LKIW------------DVSSGKCLKTLKGHSNY-----VFCCNFNPQSNLIVSGSFDESV 153
Query: 449 KVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNM 508
++W+ TG+ + L H D V + + D ++ S+ +DG +WD A G +++ +
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLID- 211
Query: 509 IEGQGHGAVFDCKCSPDGQH 528
+ V K SP+G++
Sbjct: 212 ---DDNPPVSFVKFSPNGKY 228
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 90.1 bits (222), Expect = 2e-17
Identities = 90/355 (25%), Positives = 153/355 (43%), Gaps = 52/355 (14%)
Query: 160 RLERLVP--TAVYQHMKMHK--RILGHLSSV--------YCVTFDRTGRRIFTGSDDCLV 207
RL + +P T Q ++HK R L + S YC F + + T L
Sbjct: 197 RLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYC-HFSPNSKMLATACWSGLC 255
Query: 208 KIWATDDGRLLATLRGHAAEISDMAVNYENTM--------IAAGSCDKMIRVWCLRTCAP 259
K+W+ D LL TLRGH + + + ++T+ +A+ + D +++W L + P
Sbjct: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEP 315
Query: 260 LAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPR 319
+A ++GH+ + + + P S R+L +T D + W +A ++ E
Sbjct: 316 VADIEGHTVRVARVMWHP----SGRFLGTTCYDRSWRLWDLEAQEEILHQ------EGHS 365
Query: 320 PGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNR 379
GV I +F G TG D RV+ +G+ I LE H ++ I FS
Sbjct: 366 MGVYDI--AFHQDGSLAGTGGLDAFGRVWDLRTGRC--IMFLEGHLKEIYGINFSPNGYH 421
Query: 380 FVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTV 439
+GS D T ++W ++R + T PA QNL +T +K + H N +
Sbjct: 422 IATGSGDNTCKVWDLRQRRC------VYTIPAHQNL------VTGVKFEPI----HGNFL 465
Query: 440 ITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVW 494
+T + T K+W + L GHE +V L+ D +++ + +D +W
Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISS-DGQLIATCSYDRTFKLW 519
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 89.7 bits (221), Expect = 2e-17
Identities = 83/350 (23%), Positives = 141/350 (40%), Gaps = 47/350 (13%)
Query: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241
H + ++ G+R+ TGS+D ++W+T DG+ A L+GH + ++ + E
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
Query: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301
+ C IR W + T L V +GH++ + + + L S+ D T W D
Sbjct: 74 SADC--TIRRWDVLTGQCLQVYRGHTSIVNRILV------ANNQLFSSSYDRTARVWSVD 125
Query: 302 AGTLKINPRPAK------FTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP 355
G + R + P C+ +A G L TGSTD +V+ SG
Sbjct: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
Query: 356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ---------FKRREWKSILLDM 406
+ L HT V + + +GS D T R W F+ I L++
Sbjct: 186 HQ--TLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL 243
Query: 407 ATRPAGQNLQGIEDKITKM---------------KVTMVAWDRHDNTVITAVNNMTLKVW 451
R G D+ K + + A H T+ T + + +
Sbjct: 244 VNRLV---YSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
Query: 452 NSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVK 501
++ +G+L V GH F++ +VL++A HDG + +WD+ RG++
Sbjct: 301 DAQSGELRRVFRGH---TFIINCIQVHGQVLYTASHDGALRLWDV-RGLR 346
Score = 58.2 bits (139), Expect = 7e-08
Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 22/175 (12%)
Query: 176 HKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNY 235
H+ + GH +V C+ D G FTGS D ++ W G L R H + + +
Sbjct: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLEL 243
Query: 236 ENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQF--SPLCSGSKRYLSSTGADG 293
N ++ +GS D+ ++ W T + H ++++L++ L +GS G
Sbjct: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGS----------G 293
Query: 294 TICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVY 348
C +DA + ++ R G I + G L T S D +R++
Sbjct: 294 DACARAFDAQSGEL--------RRVFRGHTFIINCIQVHGQVLYTASHDGALRLW 340
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 89.0 bits (219), Expect = 4e-17
Identities = 82/308 (26%), Positives = 131/308 (42%), Gaps = 32/308 (10%)
Query: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241
H V F G+ + TGS+D V W T G+LL L GH + + + + A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301
+ SCD +R+W + L VL+GH S+ ++ FSP R L+S G D + W
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP----DSRQLASGGWDKRVMLWDVQ 135
Query: 302 AGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE- 360
+G + + R +Q S FS LATGS D + ++ P +
Sbjct: 136 SGQM------LRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 361 LEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIED 420
LE H+ + + +S S SGS D T IW + S+L+ ++
Sbjct: 188 LEGHSANISCLCYS-ASGLLASGSWDKTIHIW---KPTTSSLLIQ------------LKG 231
Query: 421 KITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPR 480
+T +K +A+ + + +A + +KVW+ TG+ + L G D P D +
Sbjct: 232 HVTWVK--SIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP-DGK 288
Query: 481 VLFSAGHD 488
+L S D
Sbjct: 289 ILVSGAAD 296
Score = 72.4 bits (176), Expect = 4e-12
Identities = 54/215 (25%), Positives = 91/215 (42%), Gaps = 12/215 (5%)
Query: 178 RILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYEN 237
R+ GH V F G + S DC V++W + L L+GH + ++ + ++
Sbjct: 58 RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS 117
Query: 238 TMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICF 297
+A+G DK + +W +++ L +L GH SI S FSP + L++ D T+
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP----TVNCLATGSWDSTVHI 173
Query: 298 WLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEK 357
W L++ + C +SA G+ LA+GS D I ++
Sbjct: 174 W-----DLRMVTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIW--KPTTSSL 225
Query: 358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
+ +L+ H V SI FS S ++W
Sbjct: 226 LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 58.2 bits (139), Expect = 7e-08
Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 22/182 (12%)
Query: 171 QHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLA------TLRGH 224
Q +M + ++GH S+ F T + TGS D V IW D R++ L GH
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW---DLRMVTPAVSHQALEGH 191
Query: 225 AAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKR 284
+A IS + + + ++A+GS DK I +W T + L L+GH + S+ FSP +
Sbjct: 192 SANISCLCYS-ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP----DEL 246
Query: 285 YLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHI 344
+L+S G + +WD T K T + V C +F+ G L +G+ D
Sbjct: 247 WLASAGYSRMV--KVWDCNTGK-----CLETLKGVLDVAHTC-AFTPDGKILVSGAADQT 298
Query: 345 IR 346
R
Sbjct: 299 RR 300
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 89.0 bits (219), Expect = 4e-17
Identities = 87/332 (26%), Positives = 134/332 (40%), Gaps = 39/332 (11%)
Query: 211 ATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASI 270
AT+D L +GH A I+ + ++ +A S D + +W + A GH +
Sbjct: 4 ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63
Query: 271 TSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFS 330
TS+QFSP L+S D T+ W+ D + KF+E + FS
Sbjct: 64 TSVQFSP----HGNLLASASRDRTVRLWIPD--------KRGKFSEFKAHTAPVRSVDFS 111
Query: 331 AGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTAR 390
A G FLAT S D I+V+ + + L HT V +FS VS S D T +
Sbjct: 112 ADGQFLATASEDKSIKVW--SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIK 169
Query: 391 IWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKV 450
IW + Q + D + V ++ + +A ++ T+KV
Sbjct: 170 IWDTTNK---------------QCVNNFSDSVG--FANFVDFNPSGTCIASAGSDQTVKV 212
Query: 451 WNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIE 510
W+ +L+ H V + HP L +A DG + + DL G I +
Sbjct: 213 WDVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYTL----- 266
Query: 511 GQGH-GAVFDCKCSPDGQHFACTDSHGHLLIF 541
QGH G VF S G+ FA + +L++
Sbjct: 267 -QGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/254 (23%), Positives = 97/254 (38%), Gaps = 48/254 (18%)
Query: 178 RILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYEN 237
R +GH V V F G + + S D V++W D + + H A + + + +
Sbjct: 55 RYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG 114
Query: 238 TMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSP------LCSGSKRY------ 285
+A S DK I+VW + L L H+ + +FSP CS K
Sbjct: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
Query: 286 --------------------------LSSTGADGTICFWLWDAGTLKINPRPAKFTERPR 319
++S G+D T+ W +++N + + +
Sbjct: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVW-----DVRVN-KLLQHYQVHS 228
Query: 320 PGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNR 379
GV C SF G +L T S+D +++ G+ I L+ HT V ++ FS
Sbjct: 229 GGVN--CISFHPSGNYLITASSDGTLKILDLLEGR--LIYTLQGHTGPVFTVSFSKGGEL 284
Query: 380 FVSGSRDGTARIWQ 393
F SG D +W+
Sbjct: 285 FASGGADTQVLLWR 298
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 88.6 bits (218), Expect = 5e-17
Identities = 58/219 (26%), Positives = 95/219 (43%), Gaps = 14/219 (6%)
Query: 177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYE 236
K + GH VY F + + S+D ++ W +GHA + D+ ++
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
Query: 237 NTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTIC 296
+ A+GS D+ R+W PL + GH A + ++F P + YL++ D T+
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHP----NSNYLATGSTDKTVR 451
Query: 297 FWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPE 356
W G FT P ++ +FS G +LA+ D ++++ SG
Sbjct: 452 LWSAQQGN-----SVRLFTGHRGP---VLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY 503
Query: 357 KISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFK 395
K EL HTD + S+ FS S S S D + R+W +
Sbjct: 504 K--ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
Score = 63.2 bits (152), Expect = 2e-09
Identities = 62/237 (26%), Positives = 100/237 (42%), Gaps = 32/237 (13%)
Query: 260 LAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPR 319
+ +L+GH + S +F SG L S D +I +W D G+ +
Sbjct: 335 MKILRGHCGPVYSTRFLADSSG----LLSCSEDMSIRYW--DLGSFT---NTVLYQGHAY 385
Query: 320 PGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNR 379
P + S +S ++ A+GS D R++ F P +I H VD ++F SN
Sbjct: 386 PVWDLDISPYS---LYFASGSHDRTARLWSFDRTYPLRI--YAGHLADVDCVKFHPNSNY 440
Query: 380 FVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTV 439
+GS D T R+W ++ S+ L R V +A+ + +
Sbjct: 441 LATGSTDKTVRLWS--AQQGNSVRLFTGHRGP---------------VLSLAFSPNGKYL 483
Query: 440 ITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDL 496
+A + LK+W+ +G L L GH D + L P D ++ SA D +V VWD+
Sbjct: 484 ASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDI 539
Score = 54.3 bits (129), Expect = 1e-06
Identities = 49/171 (28%), Positives = 71/171 (41%), Gaps = 20/171 (11%)
Query: 329 FSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGT 388
F A L + S D IR + GS + + H V + S S F SGS D T
Sbjct: 350 FLADSSGLLSCSEDMSIRYWDLGSFTNTVL--YQGHAYPVWDLDISPYSLYFASGSHDRT 407
Query: 389 ARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTL 448
AR+W F R T P + D V V + + N + T + T+
Sbjct: 408 ARLWSFDR-----------TYPLRIYAGHLAD------VDCVKFHPNSNYLATGSTDKTV 450
Query: 449 KVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARG 499
++W++ G + + GH V L P + + L SAG D + +WDLA G
Sbjct: 451 RLWSAQQGNSVRLFTGHRGPVLSLAFSP-NGKYLASAGEDQRLKLWDLASG 500
Score = 53.1 bits (126), Expect = 2e-06
Identities = 26/93 (27%), Positives = 45/93 (48%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMI 240
GH V + F G+ + + +D +K+W G L LRGH I+ + + ++ +I
Sbjct: 466 GHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLI 525
Query: 241 AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSL 273
A+ S D +RVW +R A G S+ + +
Sbjct: 526 ASASMDNSVRVWDIRNTYCSAPADGSSSELVGV 558
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 84.0 bits (206), Expect = 1e-15
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 35/344 (10%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEIS--DMAVNYE 236
I H V C F R I T S D VKIW + G L+ T H+ +++ +
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
Query: 237 NTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTIC 296
+ ++A GS D +++W L + GH+ S+ +FSP + L+S ADGT+
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP----DDKLLASCSADGTLK 768
Query: 297 FWLWDAGTLKINPRPAKF---TERPRPGVQMI--CSSFSAGGMFLATGSTDHIIRVYFFG 351
W + + + +F E P+ +++I C S+SA G + + + +++ +
Sbjct: 769 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 825
Query: 352 SGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ------------------ 393
+ K+++ H V + FS + F++ S D T R+W+
Sbjct: 826 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDV 885
Query: 394 -FKRREWKSILLDMATRPAGQN-LQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVW 451
F+ E + +D R N G D +T+ +V+ H + N +++
Sbjct: 886 VFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 945
Query: 452 NSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWD 495
++ H+ V+ ++ D + L S+ D + VW+
Sbjct: 946 ELVNNRIFQSRFQHKKTVWHIQ-FTADEKTLISSSDDAEIQVWN 988
Score = 53.5 bits (127), Expect = 2e-06
Identities = 48/199 (24%), Positives = 80/199 (40%), Gaps = 20/199 (10%)
Query: 156 NGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDG 215
NG + LV ++Q HK+ + H+ F + + + SDD +++W
Sbjct: 939 NGAIEILELVNNRIFQSRFQHKKTVWHIQ------FTADEKTLISSSDDAEIQVWNWQLD 992
Query: 216 RLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQF 275
+ + LRGH + D + +N+ + + S D ++VW + T H ++ S
Sbjct: 993 KCIF-LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDI 1050
Query: 276 SPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMF 335
S SST AD T W +D R R CS+FS
Sbjct: 1051 SH----DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR--------CSAFSVDSTL 1098
Query: 336 LATGSTDHIIRVYFFGSGQ 354
LATG + IR++ +G+
Sbjct: 1099 LATGDDNGEIRIWNVSNGE 1117
Score = 52.4 bits (124), Expect = 4e-06
Identities = 48/199 (24%), Positives = 81/199 (40%), Gaps = 29/199 (14%)
Query: 364 HTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKIT 423
HTD V FS R S D T ++++ + G+ L +E K
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAE---------------TGEKL--LEIKAH 656
Query: 424 KMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEV----FVLEPHPFDP 479
+ +V A+ D + T + +K+WNS TG+L+H H ++V F H
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-- 714
Query: 480 RVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLL 539
+L + D + +WDL + + F H C+ SPD + A + G L
Sbjct: 715 -LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLK 768
Query: 540 IFGFGSSSKYDKIADQMFF 558
++ S+++ I + FF
Sbjct: 769 LWDATSANERKSINVKQFF 787
Score = 50.8 bits (120), Expect = 1e-05
Identities = 63/286 (22%), Positives = 114/286 (39%), Gaps = 28/286 (9%)
Query: 221 LRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCS 280
+R H + + + IA+ DK ++V+ T L ++ H + FS
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST--- 667
Query: 281 GSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSF--SAGGMFLAT 338
R++++ D + W G L + E Q+ C F S+ + LAT
Sbjct: 668 -DDRFIATCSVDKKVKIWNSMTGEL-----VHTYDEHSE---QVNCCHFTNSSHHLLLAT 718
Query: 339 GSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ-FKRR 397
GS+D ++++ Q E + + HT+ V+ +FS S S DGT ++W
Sbjct: 719 GSSDCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 776
Query: 398 EWKSILLDMATRPAGQNLQGIEDKITKMKVTM--VAWDRHDNTVITAVNNMTLKVWNSYT 455
E KSI + Q +ED M+V + +W ++ A N + +WN+ +
Sbjct: 777 ERKSINVK-------QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDS 828
Query: 456 GQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVK 501
+ GH V + P D ++ D + +W+ + K
Sbjct: 829 RSKVADCRGHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWETKKVCK 873
Score = 45.4 bits (106), Expect = 5e-04
Identities = 90/406 (22%), Positives = 144/406 (35%), Gaps = 88/406 (21%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWAT---------------------------- 212
GHLS V+ V F G T SDD +++W T
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 896
Query: 213 -DDGRLLATLRGHA--------AEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVL 263
D R L + G A++S ++ IA G + I + L
Sbjct: 897 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 956
Query: 264 QGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQ 323
H ++ +QF+ ++ L S+ D I W W G Q
Sbjct: 957 FQHKKTVWHIQFT----ADEKTLISSSDDAEIQVWNWQLDKCIF-----------LRGHQ 1001
Query: 324 MICSSFSA-GGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVS 382
F L + S D ++V+ +G EK + H V S S+ + +F S
Sbjct: 1002 ETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK--DFVCHQGTVLSCDISHDATKFSS 1059
Query: 383 GSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITA 442
S D TA+IW F +LL + L+G V A+ + T
Sbjct: 1060 TSADKTAKIWSF------DLLLPL------HELRGHNG-----CVRCSAFSVDSTLLATG 1102
Query: 443 VNNMTLKVWNSYTGQLIHVLMGHEDE--------VFVLEPHPFDPRVLFSAGHDGNVIVW 494
+N +++WN G+L+H+ +E V L P D ++L SAG G + W
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLISAG--GYIKWW 1159
Query: 495 DLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLI 540
++ G ++++ G + SPD + + D+ G L I
Sbjct: 1160 NVVTGESSQTFYT--NGTNLKKI---HVSPDFKTYVTVDNLGILYI 1200
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/207 (22%), Positives = 85/207 (41%), Gaps = 28/207 (13%)
Query: 329 FSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSG-SRDG 387
FS G +A+ D ++V+ +G EK+ E++ H D+V FS T +RF++ S D
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEVLCCAFS-TDDRFIATCSVDK 679
Query: 388 TARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMT 447
+IW G+ + ++ ++ H + T ++
Sbjct: 680 KVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 448 LKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLA-----RGVKI 502
LK+W+ + + + GH + V P D ++L S DG + +WD + + +
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINV 783
Query: 503 RSYFNMIEGQGHGAVFDCKC---SPDG 526
+ +F +E KC S DG
Sbjct: 784 KQFFLNLEDPQEDMEVIVKCCSWSADG 810
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/109 (29%), Positives = 47/109 (43%), Gaps = 8/109 (7%)
Query: 177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYE 236
K + H +V + + S D KIW+ D L LRGH + A + +
Sbjct: 1036 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1095
Query: 237 NTMIAAGSCDKMIRVW------CLRTCAPLAV--LQGHSASITSLQFSP 277
+T++A G + IR+W L CAPL+ H +T L FSP
Sbjct: 1096 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1144
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 84.0 bits (206), Expect = 1e-15
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 35/344 (10%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEIS--DMAVNYE 236
I H V C F R I T S D VKIW + G L+ T H+ +++ +
Sbjct: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
Query: 237 NTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTIC 296
+ ++A GS D +++W L + GH+ S+ +FSP + L+S ADGT+
Sbjct: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP----DDKLLASCSADGTLK 757
Query: 297 FWLWDAGTLKINPRPAKF---TERPRPGVQMI--CSSFSAGGMFLATGSTDHIIRVYFFG 351
W + + + +F E P+ +++I C S+SA G + + + +++ +
Sbjct: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLWN 814
Query: 352 SGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ------------------ 393
+ K+++ H V + FS + F++ S D T R+W+
Sbjct: 815 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDV 874
Query: 394 -FKRREWKSILLDMATRPAGQN-LQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVW 451
F+ E + +D R N G D +T+ +V+ H + N +++
Sbjct: 875 VFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 934
Query: 452 NSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWD 495
++ H+ V+ ++ D + L S+ D + VW+
Sbjct: 935 ELVNNRIFQSRFQHKKTVWHIQ-FTADEKTLISSSDDAEIQVWN 977
Score = 53.5 bits (127), Expect = 2e-06
Identities = 48/199 (24%), Positives = 80/199 (40%), Gaps = 20/199 (10%)
Query: 156 NGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDG 215
NG + LV ++Q HK+ + H+ F + + + SDD +++W
Sbjct: 928 NGAIEILELVNNRIFQSRFQHKKTVWHIQ------FTADEKTLISSSDDAEIQVWNWQLD 981
Query: 216 RLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQF 275
+ + LRGH + D + +N+ + + S D ++VW + T H ++ S
Sbjct: 982 KCIF-LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDI 1039
Query: 276 SPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMF 335
S SST AD T W +D R R CS+FS
Sbjct: 1040 SH----DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR--------CSAFSVDSTL 1087
Query: 336 LATGSTDHIIRVYFFGSGQ 354
LATG + IR++ +G+
Sbjct: 1088 LATGDDNGEIRIWNVSNGE 1106
Score = 52.4 bits (124), Expect = 4e-06
Identities = 48/199 (24%), Positives = 81/199 (40%), Gaps = 29/199 (14%)
Query: 364 HTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKIT 423
HTD V FS R S D T ++++ + G+ L +E K
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAE---------------TGEKL--LEIKAH 645
Query: 424 KMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEV----FVLEPHPFDP 479
+ +V A+ D + T + +K+WNS TG+L+H H ++V F H
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-- 703
Query: 480 RVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLL 539
+L + D + +WDL + + F H C+ SPD + A + G L
Sbjct: 704 -LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNH-----CRFSPDDKLLASCSADGTLK 757
Query: 540 IFGFGSSSKYDKIADQMFF 558
++ S+++ I + FF
Sbjct: 758 LWDATSANERKSINVKQFF 776
Score = 50.8 bits (120), Expect = 1e-05
Identities = 63/286 (22%), Positives = 114/286 (39%), Gaps = 28/286 (9%)
Query: 221 LRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCS 280
+R H + + + IA+ DK ++V+ T L ++ H + FS
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST--- 656
Query: 281 GSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSF--SAGGMFLAT 338
R++++ D + W G L + E Q+ C F S+ + LAT
Sbjct: 657 -DDRFIATCSVDKKVKIWNSMTGEL-----VHTYDEHSE---QVNCCHFTNSSHHLLLAT 707
Query: 339 GSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ-FKRR 397
GS+D ++++ Q E + + HT+ V+ +FS S S DGT ++W
Sbjct: 708 GSSDCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 765
Query: 398 EWKSILLDMATRPAGQNLQGIEDKITKMKVTM--VAWDRHDNTVITAVNNMTLKVWNSYT 455
E KSI + Q +ED M+V + +W ++ A N + +WN+ +
Sbjct: 766 ERKSINVK-------QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDS 817
Query: 456 GQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVK 501
+ GH V + P D ++ D + +W+ + K
Sbjct: 818 RSKVADCRGHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWETKKVCK 862
Score = 45.4 bits (106), Expect = 5e-04
Identities = 90/406 (22%), Positives = 144/406 (35%), Gaps = 88/406 (21%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWAT---------------------------- 212
GHLS V+ V F G T SDD +++W T
Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 885
Query: 213 -DDGRLLATLRGHA--------AEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVL 263
D R L + G A++S ++ IA G + I + L
Sbjct: 886 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 945
Query: 264 QGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQ 323
H ++ +QF+ ++ L S+ D I W W G Q
Sbjct: 946 FQHKKTVWHIQFT----ADEKTLISSSDDAEIQVWNWQLDKCIF-----------LRGHQ 990
Query: 324 MICSSFSA-GGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVS 382
F L + S D ++V+ +G EK + H V S S+ + +F S
Sbjct: 991 ETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK--DFVCHQGTVLSCDISHDATKFSS 1048
Query: 383 GSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITA 442
S D TA+IW F +LL + L+G V A+ + T
Sbjct: 1049 TSADKTAKIWSF------DLLLPL------HELRGHNG-----CVRCSAFSVDSTLLATG 1091
Query: 443 VNNMTLKVWNSYTGQLIHVLMGHEDE--------VFVLEPHPFDPRVLFSAGHDGNVIVW 494
+N +++WN G+L+H+ +E V L P D ++L SAG G + W
Sbjct: 1092 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP-DGKMLISAG--GYIKWW 1148
Query: 495 DLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLI 540
++ G ++++ G + SPD + + D+ G L I
Sbjct: 1149 NVVTGESSQTFYT--NGTNLKKI---HVSPDFKTYVTVDNLGILYI 1189
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/207 (22%), Positives = 85/207 (41%), Gaps = 28/207 (13%)
Query: 329 FSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSG-SRDG 387
FS G +A+ D ++V+ +G EK+ E++ H D+V FS T +RF++ S D
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEVLCCAFS-TDDRFIATCSVDK 668
Query: 388 TARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMT 447
+IW G+ + ++ ++ H + T ++
Sbjct: 669 KVKIW---------------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 448 LKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLA-----RGVKI 502
LK+W+ + + + GH + V P D ++L S DG + +WD + + +
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINV 772
Query: 503 RSYFNMIEGQGHGAVFDCKC---SPDG 526
+ +F +E KC S DG
Sbjct: 773 KQFFLNLEDPQEDMEVIVKCCSWSADG 799
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/109 (29%), Positives = 47/109 (43%), Gaps = 8/109 (7%)
Query: 177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYE 236
K + H +V + + S D KIW+ D L LRGH + A + +
Sbjct: 1025 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1084
Query: 237 NTMIAAGSCDKMIRVW------CLRTCAPLAV--LQGHSASITSLQFSP 277
+T++A G + IR+W L CAPL+ H +T L FSP
Sbjct: 1085 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1133
>gi|119943102 CREB binding protein isoform b [Homo sapiens]
Length = 2404
Score = 83.6 bits (205), Expect = 2e-15
Identities = 53/155 (34%), Positives = 81/155 (52%), Gaps = 8/155 (5%)
Query: 1270 PLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCEELL 1329
P+ KK + EE+++ GT+++ QPR+++ + QA E L
Sbjct: 1007 PMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELR--QALMPTLEALY 1064
Query: 1330 NLIFQCEDSEPFRQPVD--LLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRL 1387
Q +S PFRQPVD LL PDY DI+ PMD +T++ L+ G Y+ P + DV L
Sbjct: 1065 R---QDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWL 1121
Query: 1388 IFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVL 1422
+F+N+ Y K SR+Y +L+ FE+ I V+
Sbjct: 1122 MFNNAWLYN-RKTSRVYKFCSKLAEVFEQEIDPVM 1155
Score = 33.1 bits (74), Expect = 2.5
Identities = 22/66 (33%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 1184 FVAPVDLQ--AYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEP 1241
F PVD Q P Y +V P DLSTIK++L+ Y+ + +V + +N +N
Sbjct: 1073 FRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRK 1132
Query: 1242 GSPIVK 1247
S + K
Sbjct: 1133 TSRVYK 1138
>gi|119943104 CREB binding protein isoform a [Homo sapiens]
Length = 2442
Score = 83.6 bits (205), Expect = 2e-15
Identities = 53/155 (34%), Positives = 81/155 (52%), Gaps = 8/155 (5%)
Query: 1270 PLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCEELL 1329
P+ KK + EE+++ GT+++ QPR+++ + QA E L
Sbjct: 1045 PMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELR--QALMPTLEALY 1102
Query: 1330 NLIFQCEDSEPFRQPVD--LLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRL 1387
Q +S PFRQPVD LL PDY DI+ PMD +T++ L+ G Y+ P + DV L
Sbjct: 1103 R---QDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWL 1159
Query: 1388 IFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVL 1422
+F+N+ Y K SR+Y +L+ FE+ I V+
Sbjct: 1160 MFNNAWLYN-RKTSRVYKFCSKLAEVFEQEIDPVM 1193
Score = 33.1 bits (74), Expect = 2.5
Identities = 22/66 (33%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 1184 FVAPVDLQ--AYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEP 1241
F PVD Q P Y +V P DLSTIK++L+ Y+ + +V + +N +N
Sbjct: 1111 FRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRK 1170
Query: 1242 GSPIVK 1247
S + K
Sbjct: 1171 TSRVYK 1176
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 82.8 bits (203), Expect = 3e-15
Identities = 69/320 (21%), Positives = 139/320 (43%), Gaps = 31/320 (9%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWAT-DDGRLLATLRGHAAEISDMAVNYENTM 239
GH VYC F G + + D L+ +W D ATL+GH+ + ++ N + +M
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 240 IAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKR--YLSSTGA-DGTIC 296
+ + S DK + VW T + L+GH++ + S C ++R L TG+ DGT+
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNS------CYPARRGPQLVCTGSDDGTVK 177
Query: 297 FWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPE 356
W + R + + Q++ +F+ + +G D+ I+V+ Q +
Sbjct: 178 LW---------DIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVW--DLRQNK 226
Query: 357 KISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQ 416
+ H D V + S+ + +S + D T R+W + K + + N+
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK----ERCVKIFQGNVH 282
Query: 417 GIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHP 476
E + + +W + + + + VW++ + ++++ L GH + + HP
Sbjct: 283 NFEKNLLR-----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Query: 477 FDPRVLFSAGHDGNVIVWDL 496
+P ++ SA D + + ++
Sbjct: 338 DEP-IIISASSDKRLYMGEI 356
Score = 64.3 bits (155), Expect = 1e-09
Identities = 79/331 (23%), Positives = 131/331 (39%), Gaps = 47/331 (14%)
Query: 253 CLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW--LWDAGTLKINPR 310
C AP+ +L GH + +F P +GS L+S G D I W D
Sbjct: 52 CSSLQAPIMLLSGHEGEVYCCKFHP--NGST--LASAGFDRLILLWNVYGDCDNYA---- 103
Query: 311 PAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDS 370
T + G M ++ G L + STD + V+ +G E++ L+ HT V+S
Sbjct: 104 ----TLKGHSGAVMEL-HYNTDGSMLFSASTDKTVAVWDSETG--ERVKRLKGHTSFVNS 156
Query: 371 IQFSNTSNRFV-SGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTM 429
+ + V +GS DGT ++W D+ + A Q Q +V
Sbjct: 157 CYPARRGPQLVCTGSDDGTVKLW------------DIRKKAAIQTFQ------NTYQVLA 198
Query: 430 VAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDG 489
V ++ + +I+ + +KVW+ +L + + GH D V L + L S D
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDN 257
Query: 490 NVIVWDLARGVKIRSYFNMIEGQGHG---AVFDCKCSPDGQHFACTDSHGHLLIFGFGSS 546
V VWD+ + +G H + C SPDG A + + ++ S
Sbjct: 258 TVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR 317
Query: 547 SKYDKI------ADQMFFHSDYRPLIRDANN 571
K+ +++ FH D P+I A++
Sbjct: 318 RILYKLPGHAGSINEVAFHPD-EPIIISASS 347
Score = 57.0 bits (136), Expect = 2e-07
Identities = 59/265 (22%), Positives = 101/265 (38%), Gaps = 58/265 (21%)
Query: 169 VYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEI 228
VY + + GH +V + ++ G +F+ S D V +W ++ G + L+GH + +
Sbjct: 95 VYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV 154
Query: 229 SD----------------------------------------MAVNYENT--MIAAGSCD 246
+ +AV + +T I +G D
Sbjct: 155 NSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGID 214
Query: 247 KMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLK 306
I+VW LR ++GH+ S+T L S GS YL S D T+ +WD
Sbjct: 215 NDIKVWDLRQNKLTYTMRGHADSVTGLSLS--SEGS--YLLSNAMDNTV--RVWDVRPFA 268
Query: 307 INPRPAKFTERPRPGVQ--MICSSFSAGGMFLATGSTDHII--------RVYFFGSGQPE 356
R K + + ++ S+S G +A GS D + R+ + G
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAG 328
Query: 357 KISELEFHTDKVDSIQFSNTSNRFV 381
I+E+ FH D+ I S+ ++
Sbjct: 329 SINEVAFHPDEPIIISASSDKRLYM 353
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 82.8 bits (203), Expect = 3e-15
Identities = 66/230 (28%), Positives = 105/230 (45%), Gaps = 32/230 (13%)
Query: 181 GHLSSVYCVTFDRTGRR-IFTGSDDCLVKIW-----------ATDDGRLL----ATLRGH 224
GH SV V R + TGS DC VK+W A D+G +L T R H
Sbjct: 419 GHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCH 478
Query: 225 AAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKR 284
+I+ +A+ + ++A GS D+ ++W L C L V GH + +QFSP+ +
Sbjct: 479 DKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPM----DQ 534
Query: 285 YLSSTGADGTICFW-LWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDH 343
L++ ADGTI W L D LK T + + S G L++GS D
Sbjct: 535 VLATASADGTIKLWALQDFSCLK--------TFEGHDASVLKVAFVSRGTQLLSSGS-DG 585
Query: 344 IIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ 393
+++++ + E + L+ H DKV + S + ++G+ D +W+
Sbjct: 586 LVKLWTIKNN--ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Score = 57.4 bits (137), Expect = 1e-07
Identities = 89/426 (20%), Positives = 155/426 (36%), Gaps = 111/426 (26%)
Query: 169 VYQHMKMHKRILGHLSSVYCVTF--DRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAA 226
+ +H H G V+ V F D T +F+ + D +++W+ D LA L H +
Sbjct: 138 IVRHYGTH-HFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYS 196
Query: 227 EISDMAVNYE-NTMIAAGSCDKMIRVWCLRTC---APLAVLQGHSASITSLQFSPLCSGS 282
++ +A + + +TM+++G DK+ +W L++C + V + A++ + G
Sbjct: 197 AVTSLAFSADGHTMLSSGR-DKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGV 255
Query: 283 KR---YLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMI-CSSFSAGGMFLAT 338
K Y + G GT+ W +G + P PG ++ C+ G+ L T
Sbjct: 256 KSPGLYFLTAGDQGTLRVWEAASGQCVYTQ-----AQPPGPGQELTHCTLAHTAGVVL-T 309
Query: 339 GSTDHIIRVYFFGS--------GQPEKISELEF--------------------------- 363
+ DH + +Y S G E++ ++ F
Sbjct: 310 ATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC 369
Query: 364 -----HTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKR---------------------- 396
HTD V ++ F S ++D + RIW+ +
Sbjct: 370 QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCC 429
Query: 397 -----------------REW--KSILLDMATRP-------AGQNLQGIEDKITKMKVTMV 430
+ W LL T P Q Q DK + V
Sbjct: 430 SRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK----DINSV 485
Query: 431 AWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGN 490
A +D + T + T K+W QL+ V GH ++ ++ P D +VL +A DG
Sbjct: 486 AIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD-QVLATASADGT 544
Query: 491 VIVWDL 496
+ +W L
Sbjct: 545 IKLWAL 550
Score = 55.1 bits (131), Expect = 6e-07
Identities = 90/373 (24%), Positives = 151/373 (40%), Gaps = 59/373 (15%)
Query: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLAT--LRGHAAEISDMAVNYENT- 238
H + V + FD T + TG D V++W D R T RG + +A + + T
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVW--DIVRHYGTHHFRGSPGVVHLVAFHPDPTR 165
Query: 239 -MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICF 297
++ + + D IRVW L+ + LAVL H +++TSL F S + S+G D IC
Sbjct: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAF----SADGHTMLSSGRD-KICI 220
Query: 298 WLWDAGTLKINPRPAKFTE------RPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFG 351
+WD + + F P V + + G++ T +RV+
Sbjct: 221 -IWDLQSCQATRTVPVFESVEAAVLLPEEPVSQL--GVKSPGLYFLTAGDQGTLRVWEAA 277
Query: 352 SGQ--------PEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIL 403
SGQ P EL T ++T+ ++ + D ++ E +S+
Sbjct: 278 SGQCVYTQAQPPGPGQELTHCT-------LAHTAGVVLTATADHNLLLY-----EARSLR 325
Query: 404 LDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLM 463
L + G +++ ++ D+ V+ A N+ LKV+ T +L
Sbjct: 326 LQ-------KQFAGYSEEVLDVRFL----GPEDSHVVVASNSPCLKVFELQT-SACQILH 373
Query: 464 GHEDEVFVLEPHPFDPRVLF-SAGHDGNVIVWDLARGVKIRSYFNMIEGQGH-GAVFDCK 521
GH D V L+ F LF S D +V +W + + ++ + +G GH +V
Sbjct: 374 GHTDIVLALD--VFRKGWLFASCAKDQSVRIWRMNKAGQVMC---VAQGSGHTHSVGTVC 428
Query: 522 CSPDGQHFACTDS 534
CS + F T S
Sbjct: 429 CSRLKESFLVTGS 441
Score = 53.5 bits (127), Expect = 2e-06
Identities = 91/436 (20%), Positives = 165/436 (37%), Gaps = 72/436 (16%)
Query: 85 LLEQEIPQSVPGVQT----LLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNY 140
+L E P S GV++ L AG Q LR VW+ ++ ++ P P
Sbjct: 243 VLLPEEPVSQLGVKSPGLYFLTAGDQGTLR--------VWEAASGQCVYTQAQPPGPGQE 294
Query: 141 GSPPSIADTLFSRKLNGKYRLERLVPTAVYQH---------MKMHKRILGHLSSVYCVTF 191
+ ++A T +V TA H +++ K+ G+ V V F
Sbjct: 295 LTHCTLAHTA------------GVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRF 342
Query: 192 -DRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIR 250
+ S+ +K++ L GH + + V + + A+ + D+ +R
Sbjct: 343 LGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVR 401
Query: 251 VWCLRTCAPLAVL---QGHSASITSLQFSPLCSGSKRYLSSTGA-DGTICFWLWDAGTLK 306
+W + + + GH+ S+ ++ CS K TG+ D T+ W L
Sbjct: 402 IWRMNKAGQVMCVAQGSGHTHSVGTV----CCSRLKESFLVTGSQDCTVKLWPLPKALLS 457
Query: 307 INPRP--------AKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKI 358
N P A+ T+R + + + LATGS D +++ Q + +
Sbjct: 458 KNTAPDNGPILLQAQTTQRCHDK-DINSVAIAPNDKLLATGSQDRTAKLWALP--QCQLL 514
Query: 359 SELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGI 418
H + +QFS + S DGT ++W L D + + +G
Sbjct: 515 GVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWA---------LQDFSCL---KTFEGH 562
Query: 419 EDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFD 478
+ + K VA+ ++++ ++ +K+W + + L HED+V+ L D
Sbjct: 563 DASVLK-----VAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLD 617
Query: 479 PRVLFSAGHDGNVIVW 494
L A D VI+W
Sbjct: 618 DHALTGAS-DSRVILW 632
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 80.5 bits (197), Expect = 1e-14
Identities = 89/378 (23%), Positives = 155/378 (41%), Gaps = 53/378 (14%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDD----GRLLATLRGHAAE--------- 227
GH S V+ ++ + +GS D +IW + G LR E
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNK 226
Query: 228 -ISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYL 286
++ + N E T++A GS D R+W + + L H I +L+++ ++
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNK----KGNFI 281
Query: 287 SSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIR 346
S G D T +WDA T +F P + + S + A+ STD I
Sbjct: 282 LSAGVDKTTI--IWDAHT---GEAKQQFPFHSAPALDVDWQSNNT----FASCSTDMCIH 332
Query: 347 VYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDM 406
V G +P I + HT++V++I++ T N S S D T +IW K+
Sbjct: 333 VCKLGQDRP--IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDN-------- 382
Query: 407 ATRPAGQNLQGIEDKITKMKVTMVAWDRHD---NTVITAVN-NMTLKVWNSYTGQLIHVL 462
+LQ +I +K + ++ N ++ + + + T+++W+ G IH L
Sbjct: 383 ----CVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTL 438
Query: 463 MGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKC 522
H++ V+ + P D R L S D V +W+ G + SY +G G +F+
Sbjct: 439 TKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQTGALVHSY------RGTGGIFEVCW 491
Query: 523 SPDGQHFACTDSHGHLLI 540
+ G + S G + +
Sbjct: 492 NAAGDKVGASASDGSVCV 509
Score = 69.3 bits (168), Expect = 3e-11
Identities = 78/336 (23%), Positives = 139/336 (41%), Gaps = 68/336 (20%)
Query: 221 LRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLR---TCAPLAVLQGH----------- 266
LRGH +E+ A N + ++A+GS D R+W L T ++ H
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 267 SASITSLQFSPLCSGSKRYLSSTGA-DGTICFWLWD---AGTLKINPRPAKFTERPRPGV 322
+ +TSL ++ S+ L +TG+ DG W D A TL + P
Sbjct: 225 NKDVTSLDWN-----SEGTLLATGSYDGFARIWTKDGNLASTLGQHKGP----------- 268
Query: 323 QMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVS 382
+ ++ G F+ + D ++ +G+ ++ + FH+ + + + +N F S
Sbjct: 269 -IFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQ--QFPFHSAPALDVDWQS-NNTFAS 324
Query: 383 GSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITA 442
S D + + + RP + QG +++ +K WD N + +
Sbjct: 325 CSTDMCIHVCKLGQ-----------DRPI-KTFQGHTNEVNAIK-----WDPTGNLLASC 367
Query: 443 VNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDP--------RVLFSAGHDGNVIVW 494
++MTLK+W+ +H L H E++ ++ P P +L SA D V +W
Sbjct: 368 SDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLW 427
Query: 495 DLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFA 530
D+ RG+ I + E V+ SPDG++ A
Sbjct: 428 DVDRGICIHTLTKHQE-----PVYSVAFSPDGRYLA 458
Score = 55.8 bits (133), Expect = 4e-07
Identities = 38/138 (27%), Positives = 59/138 (42%), Gaps = 13/138 (9%)
Query: 177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVN-- 234
K GH + V + +D TG + + SDD +KIW+ + L+ H EI + +
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
Query: 235 -------YENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLS 287
N M+A+ S D +R+W + + L H + S+ FSP RYL+
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP----DGRYLA 458
Query: 288 STGADGTICFWLWDAGTL 305
S D + W G L
Sbjct: 459 SGSFDKCVHIWNTQTGAL 476
Score = 55.5 bits (132), Expect = 5e-07
Identities = 75/322 (23%), Positives = 124/322 (38%), Gaps = 44/322 (13%)
Query: 186 VYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSC 245
V + ++ G + TGS D +IW T DG L +TL H I + N + I +
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 246 DKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTL 305
DK +W T HSA + + S +S D +C + G
Sbjct: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-----SNNTFASCSTD--MCIHVCKLG-- 337
Query: 306 KINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHT 365
RP K + V I + G LA+ S D ++++ Q + +L+ H
Sbjct: 338 --QDRPIKTFQGHTNEVNAI--KWDPTGNLLASCSDDMTLKIW--SMKQDNCVHDLQAHN 391
Query: 366 DKVDSIQFS---------NTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQ 416
++ +I++S N + S S D T R+W R I + T+
Sbjct: 392 KEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDR----GICIHTLTK------- 440
Query: 417 GIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHP 476
+ V VA+ + + + + +WN+ TG L+H G +F + +
Sbjct: 441 ------HQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNA 493
Query: 477 FDPRVLFSAGHDGNVIVWDLAR 498
+V SA DG+V V DL +
Sbjct: 494 AGDKVGASAS-DGSVCVLDLRK 514
Score = 50.1 bits (118), Expect = 2e-05
Identities = 39/148 (26%), Positives = 60/148 (40%), Gaps = 11/148 (7%)
Query: 355 PEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWK---SILLDMATRPA 411
P K L H +V ++ S+ SGS D TARIW ++L R
Sbjct: 159 PNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218
Query: 412 GQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFV 471
GQ++ +D VT + W+ + T + ++W G L L H+ +F
Sbjct: 219 GQDVPSNKD------VTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFA 271
Query: 472 LEPHPFDPRVLFSAGHDGNVIVWDLARG 499
L+ + + SAG D I+WD G
Sbjct: 272 LKWNK-KGNFILSAGVDKTTIIWDAHTG 298
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 79.0 bits (193), Expect = 4e-14
Identities = 72/344 (20%), Positives = 139/344 (40%), Gaps = 45/344 (13%)
Query: 175 MHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVN 234
+ + GH +V CV F +++ +GS D + +W GH ++ + +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 235 YENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGT 294
++A+GS DK +R+W V + H+A++ S+ F CS + +++++ D T
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF---CSDGQSFVTASD-DKT 126
Query: 295 ICFWLWDAGTLKINPRPAKFTERPRPGVQMI-CSSFSAGGMFLATGSTDHIIRVYFFGSG 353
+ W KF + + C+ FS G + + S D ++++
Sbjct: 127 VKVWA---------THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW--DKS 175
Query: 354 QPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQ 413
E + H V + F + + D T ++W D+ T Q
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW------------DVRTHRLLQ 223
Query: 414 NLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLE 473
+ Q + V +++ N +ITA ++ TLK+ + G+L++ L GH+ +
Sbjct: 224 HYQ-----LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV- 277
Query: 474 PHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAV 517
S G D V+VW +S F++++ HG V
Sbjct: 278 AFSRTGEYFASGGSDEQVMVW--------KSNFDIVD---HGEV 310
Score = 61.2 bits (147), Expect = 9e-09
Identities = 74/330 (22%), Positives = 124/330 (37%), Gaps = 39/330 (11%)
Query: 213 DDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITS 272
+D L +GH ++ + + +A+GS D + VW ++ + GH ++T
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 273 LQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAG 332
+ FSP S L+S D T+ W+ + R T R F +
Sbjct: 67 VNFSP----SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR--------SVHFCSD 114
Query: 333 GMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
G T S D ++V+ + + + + L H + V +FS VS S D T ++W
Sbjct: 115 GQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 393 QFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWN 452
RE + VT V + + A + T+KVW+
Sbjct: 173 DKSSRECVHSYCEHGG-----------------FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 453 SYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQ 512
T +L+ H V L HP L +A D + + DL G R + +
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILDLMEG---RLLYTL---H 268
Query: 513 GH-GAVFDCKCSPDGQHFACTDSHGHLLIF 541
GH G S G++FA S ++++
Sbjct: 269 GHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 79.0 bits (193), Expect = 4e-14
Identities = 72/344 (20%), Positives = 139/344 (40%), Gaps = 45/344 (13%)
Query: 175 MHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVN 234
+ + GH +V CV F +++ +GS D + +W GH ++ + +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 235 YENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGT 294
++A+GS DK +R+W V + H+A++ S+ F CS + +++++ D T
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF---CSDGQSFVTASD-DKT 126
Query: 295 ICFWLWDAGTLKINPRPAKFTERPRPGVQMI-CSSFSAGGMFLATGSTDHIIRVYFFGSG 353
+ W KF + + C+ FS G + + S D ++++
Sbjct: 127 VKVWA---------THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW--DKS 175
Query: 354 QPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQ 413
E + H V + F + + D T ++W D+ T Q
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW------------DVRTHRLLQ 223
Query: 414 NLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLE 473
+ Q + V +++ N +ITA ++ TLK+ + G+L++ L GH+ +
Sbjct: 224 HYQ-----LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV- 277
Query: 474 PHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAV 517
S G D V+VW +S F++++ HG V
Sbjct: 278 AFSRTGEYFASGGSDEQVMVW--------KSNFDIVD---HGEV 310
Score = 61.2 bits (147), Expect = 9e-09
Identities = 74/330 (22%), Positives = 124/330 (37%), Gaps = 39/330 (11%)
Query: 213 DDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITS 272
+D L +GH ++ + + +A+GS D + VW ++ + GH ++T
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 273 LQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAG 332
+ FSP S L+S D T+ W+ + R T R F +
Sbjct: 67 VNFSP----SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR--------SVHFCSD 114
Query: 333 GMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
G T S D ++V+ + + + + L H + V +FS VS S D T ++W
Sbjct: 115 GQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 393 QFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWN 452
RE + VT V + + A + T+KVW+
Sbjct: 173 DKSSRECVHSYCEHGG-----------------FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 453 SYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQ 512
T +L+ H V L HP L +A D + + DL G R + +
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILDLMEG---RLLYTL---H 268
Query: 513 GH-GAVFDCKCSPDGQHFACTDSHGHLLIF 541
GH G S G++FA S ++++
Sbjct: 269 GHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 79.0 bits (193), Expect = 4e-14
Identities = 88/376 (23%), Positives = 153/376 (40%), Gaps = 49/376 (13%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDD----GRLLATLR------GHAA---- 226
GH S V+ ++ + +GS D +IW ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 227 EISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYL 286
+++ + N + T++A GS D R+W + L H I +L+++ Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK----KGNYV 291
Query: 287 SSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIR 346
S G D T W G K +F P + + + M A+ STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK-----QQFPFHSAPALDVDWQN----NMTFASCSTDMCIH 342
Query: 347 VYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDM 406
V G P K + HT++V++I++ + S S D T +IW K+ + + D+
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---DACVHDL 397
Query: 407 ATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVI--TAVNNMTLKVWNSYTGQLIHVLMG 464
E K T A +++++ +A + T+++W+ G H LM
Sbjct: 398 QAHSK-------EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK 450
Query: 465 HEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSP 524
H++ V+ + P D + L S D V +W+ G + SY QG G +F+ +
Sbjct: 451 HQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIFEVCWNA 503
Query: 525 DGQHFACTDSHGHLLI 540
G + S G + +
Sbjct: 504 RGDKVGASASDGSVCV 519
Score = 57.0 bits (136), Expect = 2e-07
Identities = 77/360 (21%), Positives = 125/360 (34%), Gaps = 82/360 (22%)
Query: 221 LRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCS 280
LRGH +E+ A N + ++A+GS D R+W L + + T L C
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN--------ENSNGGSTQLVLRH-CI 225
Query: 281 GSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGS 340
+ + D T W ++ G LA GS
Sbjct: 226 REGGHDVPSNKDVTSLDW-------------------------------NSDGTLLAMGS 254
Query: 341 TDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWK 400
D R++ + S L H + +++++ N +S D T IW E K
Sbjct: 255 YDGFARIW---TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAK 311
Query: 401 SILLDMATRPA----GQNLQGIEDKITKM---------------------KVTMVAWDRH 435
+ PA QN T M +V + WD
Sbjct: 312 Q-QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPS 370
Query: 436 DNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPR--------VLFSAGH 487
+ + ++MTLK+W+ +H L H E++ ++ P P +L SA
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 488 DGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSS 547
D V +WD+ +GV + E V+ SPDG++ A ++ I+ S S
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQE-----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS 485
Score = 53.9 bits (128), Expect = 1e-06
Identities = 37/138 (26%), Positives = 63/138 (45%), Gaps = 13/138 (9%)
Query: 177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEI-------S 229
K GH + V + +D +G + + SDD +KIW+ + L+ H+ EI +
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 230 DMAVNYENT--MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLS 287
A + N+ M+A+ S D +R+W + L H + S+ FSP +YL+
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP----DGKYLA 468
Query: 288 STGADGTICFWLWDAGTL 305
S D + W +G+L
Sbjct: 469 SGSFDKYVHIWNTQSGSL 486
Score = 47.0 bits (110), Expect = 2e-04
Identities = 39/148 (26%), Positives = 60/148 (40%), Gaps = 11/148 (7%)
Query: 355 PEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRRE---WKSILLDMATRPA 411
P K + L H +V ++ S+ SGS D TARIW ++L R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 412 GQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFV 471
G ++ +D VT + W+ + + ++W G L L H+ +F
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281
Query: 472 LEPHPFDPRVLFSAGHDGNVIVWDLARG 499
L+ + VL SAG D I+WD G
Sbjct: 282 LKWNKKGNYVL-SAGVDKTTIIWDAHTG 308
Score = 35.4 bits (80), Expect = 0.51
Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENT 238
++ H VY V F G+ + +GS D V IW T G L+ + +G I ++ N
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGD 506
Query: 239 MIAAGSCDKMIRV 251
+ A + D + V
Sbjct: 507 KVGASASDGSVCV 519
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 79.0 bits (193), Expect = 4e-14
Identities = 88/376 (23%), Positives = 153/376 (40%), Gaps = 49/376 (13%)
Query: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDD----GRLLATLR------GHAA---- 226
GH S V+ ++ + +GS D +IW ++ G LR GH
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNK 236
Query: 227 EISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYL 286
+++ + N + T++A GS D R+W + L H I +L+++ Y+
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNK----KGNYV 291
Query: 287 SSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIR 346
S G D T W G K +F P + + + M A+ STD I
Sbjct: 292 LSAGVDKTTIIWDAHTGEAK-----QQFPFHSAPALDVDWQN----NMTFASCSTDMCIH 342
Query: 347 VYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDM 406
V G P K + HT++V++I++ + S S D T +IW K+ + + D+
Sbjct: 343 VCRLGCDHPVKT--FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ---DACVHDL 397
Query: 407 ATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVI--TAVNNMTLKVWNSYTGQLIHVLMG 464
E K T A +++++ +A + T+++W+ G H LM
Sbjct: 398 QAHSK-------EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK 450
Query: 465 HEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSP 524
H++ V+ + P D + L S D V +W+ G + SY QG G +F+ +
Sbjct: 451 HQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSLVHSY------QGTGGIFEVCWNA 503
Query: 525 DGQHFACTDSHGHLLI 540
G + S G + +
Sbjct: 504 RGDKVGASASDGSVCV 519
Score = 57.0 bits (136), Expect = 2e-07
Identities = 77/360 (21%), Positives = 125/360 (34%), Gaps = 82/360 (22%)
Query: 221 LRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCS 280
LRGH +E+ A N + ++A+GS D R+W L + + T L C
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN--------ENSNGGSTQLVLRH-CI 225
Query: 281 GSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGS 340
+ + D T W ++ G LA GS
Sbjct: 226 REGGHDVPSNKDVTSLDW-------------------------------NSDGTLLAMGS 254
Query: 341 TDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWK 400
D R++ + S L H + +++++ N +S D T IW E K
Sbjct: 255 YDGFARIW---TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAK 311
Query: 401 SILLDMATRPA----GQNLQGIEDKITKM---------------------KVTMVAWDRH 435
+ PA QN T M +V + WD
Sbjct: 312 Q-QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPS 370
Query: 436 DNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPR--------VLFSAGH 487
+ + ++MTLK+W+ +H L H E++ ++ P P +L SA
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 488 DGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSS 547
D V +WD+ +GV + E V+ SPDG++ A ++ I+ S S
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQE-----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS 485
Score = 53.9 bits (128), Expect = 1e-06
Identities = 37/138 (26%), Positives = 63/138 (45%), Gaps = 13/138 (9%)
Query: 177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEI-------S 229
K GH + V + +D +G + + SDD +KIW+ + L+ H+ EI +
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 230 DMAVNYENT--MIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLS 287
A + N+ M+A+ S D +R+W + L H + S+ FSP +YL+
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP----DGKYLA 468
Query: 288 STGADGTICFWLWDAGTL 305
S D + W +G+L
Sbjct: 469 SGSFDKYVHIWNTQSGSL 486
Score = 47.0 bits (110), Expect = 2e-04
Identities = 39/148 (26%), Positives = 60/148 (40%), Gaps = 11/148 (7%)
Query: 355 PEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRRE---WKSILLDMATRPA 411
P K + L H +V ++ S+ SGS D TARIW ++L R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 412 GQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFV 471
G ++ +D VT + W+ + + ++W G L L H+ +F
Sbjct: 229 GHDVPSNKD------VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFA 281
Query: 472 LEPHPFDPRVLFSAGHDGNVIVWDLARG 499
L+ + VL SAG D I+WD G
Sbjct: 282 LKWNKKGNYVL-SAGVDKTTIIWDAHTG 308
Score = 35.4 bits (80), Expect = 0.51
Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENT 238
++ H VY V F G+ + +GS D V IW T G L+ + +G I ++ N
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGD 506
Query: 239 MIAAGSCDKMIRV 251
+ A + D + V
Sbjct: 507 KVGASASDGSVCV 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,438,823
Number of Sequences: 37866
Number of extensions: 3686741
Number of successful extensions: 31993
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 446
Number of HSP's successfully gapped in prelim test: 695
Number of HSP's that attempted gapping in prelim test: 18561
Number of HSP's gapped (non-prelim): 8565
length of query: 1821
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1704
effective length of database: 13,817,196
effective search space: 23544501984
effective search space used: 23544501984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.