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Search of human proteins with 33356128
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33356128 NMDA receptor regulated 1-like protein isoform 1
[Homo sapiens]
(864 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Ho... 1729 0.0
gi|17149828 NMDA receptor regulated 1 [Homo sapiens] 1264 0.0
gi|160707985 NMDA receptor regulated 1-like protein isoform 3 [H... 847 0.0
gi|33356130 NMDA receptor regulated 1-like protein isoform 2 [Ho... 613 e-175
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 49 2e-05
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 47 8e-05
gi|148746195 trichohyalin [Homo sapiens] 47 1e-04
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 47 1e-04
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 47 1e-04
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 46 1e-04
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 46 1e-04
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 46 1e-04
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 46 2e-04
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 45 3e-04
gi|239752449 PREDICTED: hypothetical protein [Homo sapiens] 45 4e-04
gi|4827046 U2 small nuclear RNA auxiliary factor 1-like 2 [Homo ... 45 4e-04
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 44 6e-04
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 44 6e-04
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 44 8e-04
gi|221219020 NYD-SP11 protein [Homo sapiens] 44 8e-04
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 43 0.001
gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens] 43 0.001
gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo ... 43 0.001
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 43 0.001
gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo... 43 0.001
gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo... 43 0.001
gi|157785548 PAS domain containing 1 [Homo sapiens] 43 0.001
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 42 0.002
gi|189083802 myosin VIIA isoform 2 [Homo sapiens] 42 0.002
gi|189083800 myosin VIIA isoform 3 [Homo sapiens] 42 0.002
>gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Homo
sapiens]
Length = 864
Score = 1729 bits (4478), Expect = 0.0
Identities = 864/864 (100%), Positives = 864/864 (100%)
Query: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG
Sbjct: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
Query: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL
Sbjct: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
Query: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV
Sbjct: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
Query: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL
Sbjct: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
Query: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL
Sbjct: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
Query: 301 VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS 360
VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS
Sbjct: 301 VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS 360
Query: 361 PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKH 420
PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKH
Sbjct: 361 PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKH 420
Query: 421 IGNLKEAAKWMDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLN 480
IGNLKEAAKWMDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLN
Sbjct: 421 IGNLKEAAKWMDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLN 480
Query: 481 EMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVD 540
EMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVD
Sbjct: 481 EMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVD 540
Query: 541 LLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQR 600
LLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQR
Sbjct: 541 LLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQR 600
Query: 601 RAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKF 660
RAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKF
Sbjct: 601 RAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKF 660
Query: 661 LIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKSVS 720
LIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKSVS
Sbjct: 661 LIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKSVS 720
Query: 721 NHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQE 780
NHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQE
Sbjct: 721 NHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQE 780
Query: 781 KAIAIATRLDETIKDKDVKTLIKVSEALLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPA 840
KAIAIATRLDETIKDKDVKTLIKVSEALLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPA
Sbjct: 781 KAIAIATRLDETIKDKDVKTLIKVSEALLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPA 840
Query: 841 VNEVDNPNVALNHTANYDVLANEI 864
VNEVDNPNVALNHTANYDVLANEI
Sbjct: 841 VNEVDNPNVALNHTANYDVLANEI 864
>gi|17149828 NMDA receptor regulated 1 [Homo sapiens]
Length = 866
Score = 1264 bits (3271), Expect = 0.0
Identities = 611/866 (70%), Positives = 741/866 (85%), Gaps = 2/866 (0%)
Query: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
MP V LPPKE+ LFKRIL+CYE KQY+NGLKFCK ILSNPKFAEHGETLAMKGLTLNCLG
Sbjct: 1 MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLG 60
Query: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
KKEEAYE VR+GLRND+KSHVCWHVYGLLQRSDKKYDEAIKCYRNALK DKDNLQILRDL
Sbjct: 61 KKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDL 120
Query: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
SLLQIQMRDLEGYRETRYQLLQLRP QRASWIGYAIAYHLL+DY+MA K+LEEFR+TQQ
Sbjct: 121 SLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQT 180
Query: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
P+K+DYEYSEL+LYQNQV+REA L +E+LEH+ YEKQICDKL VEE KGE+LL+L RL
Sbjct: 181 SPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRL 240
Query: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
++A++V++ L +RN ENW YY+GLEKAL+ + + ERL+IYEE ++P+ + PRRLPL
Sbjct: 241 EDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNF 300
Query: 301 VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS 360
+ GE+F+E +DKFLR+NFSKGCPP+F TL+SLY + EKV+II+ELV YE SLK+C F+
Sbjct: 301 LSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFN 360
Query: 361 PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKH 420
P ++G++EPPTTLLWVQY+LAQH+DK+GQ S+AL+YIN AI STPTLIELF +KAKIYKH
Sbjct: 361 PNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKH 420
Query: 421 IGNLKEAAKWMDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLN 480
GN+KEAA+WMDEAQ+LDTADRFINSKCAKYML+AN+IKEAEEMCSKFTREGTSA+ENLN
Sbjct: 421 AGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLN 480
Query: 481 EMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVD 540
EMQCMWFQTEC AY+ + ++G+ALKKCHE+ERHF EITDDQFDFHTYCMRK+TLR+YVD
Sbjct: 481 EMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVD 540
Query: 541 LLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQR 600
LL+LED+LR+H FYFKAAR AIEIYLKL+DNPLT+E+K+ E ++ N+S KELKK+ +KQR
Sbjct: 541 LLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQR 600
Query: 601 RAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKF 660
RAQKKA++EEE+K+AE+E+QQ+NQKKK+D+++EE G KEELIPEKL +VE PLEEA+KF
Sbjct: 601 RAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKF 660
Query: 661 LIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIR-FSKSV 719
L PLKNLV + I+THL AFEIYFRK KFLLMLQSVKRAFAI+S++PWLHEC+IR F+ +V
Sbjct: 661 LTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAV 720
Query: 720 SNHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQ 779
+L D V VL QEM ++F + ++FNE FLKRN+ SL H LS AKM+Y+LD S Q
Sbjct: 721 CESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQ 780
Query: 780 EKAIAIATRLDETIKDKDVKTLIKVSEALLDGSFGNCSSQYEEYRMACHNLLPFTSAFLP 839
++AI +AT LDE++ +++++T ++V EAL DGS G+C E YR CH L P+ AF+P
Sbjct: 781 KRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMP 840
Query: 840 AVNEVD-NPNVALNHTANYDVLANEI 864
E D V + +A + LANEI
Sbjct: 841 PGYEEDMKITVNGDSSAEAEELANEI 866
>gi|160707985 NMDA receptor regulated 1-like protein isoform 3 [Homo
sapiens]
Length = 429
Score = 847 bits (2189), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG
Sbjct: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
Query: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL
Sbjct: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
Query: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV
Sbjct: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
Query: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL
Sbjct: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
Query: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL
Sbjct: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
Query: 301 VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS 360
VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS
Sbjct: 301 VPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFS 360
Query: 361 PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYK 419
PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYK
Sbjct: 361 PYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYK 419
>gi|33356130 NMDA receptor regulated 1-like protein isoform 2 [Homo
sapiens]
Length = 311
Score = 613 bits (1580), Expect = e-175
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG
Sbjct: 1 MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLG 60
Query: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL
Sbjct: 61 KKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDL 120
Query: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV
Sbjct: 121 SLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV 180
Query: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL
Sbjct: 181 PPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRL 240
Query: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL
Sbjct: 241 KEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTL 300
Query: 301 VPG 303
VPG
Sbjct: 301 VPG 303
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 49.3 bits (116), Expect = 2e-05
Identities = 26/66 (39%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E K++E E KE KK K + +K+ + EEE K +R+R++K ++++R+EEEEE
Sbjct: 26 EGKRKEKRKEKRKEKEKKK---KTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEE 82
Query: 636 SGLKEE 641
KEE
Sbjct: 83 EEEKEE 88
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/83 (33%), Positives = 48/83 (57%), Gaps = 5/83 (6%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
T E++++E + KE +K K++ +KK K E+RK E E +++ +K+K+ +EEE
Sbjct: 16 TEETEEEE--EKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEE 73
Query: 634 EASGLKEELIPEKLERVENPLEE 656
E +EE E+ E+ E EE
Sbjct: 74 EREEEEEE---EEEEKEEEEKEE 93
Score = 40.0 bits (92), Expect = 0.009
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 14/73 (19%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERE--------------RQQ 621
E ++++ E KE ++ K++R +KK K EEER+ E E R++
Sbjct: 39 EKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRK 98
Query: 622 KNQKKKRDEEEEE 634
K +K++R EEEEE
Sbjct: 99 KKKKRRRKEEEEE 111
Score = 37.7 bits (86), Expect = 0.046
Identities = 23/82 (28%), Positives = 46/82 (56%), Gaps = 3/82 (3%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKN-QKKKRDEEEEE 634
+ K+++ E +E ++ +++ ++K K +E+RK E++++ K +K+K EEEE+
Sbjct: 3 KKKKKKETEETEETEETEE--EEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 635 ASGLKEELIPEKLERVENPLEE 656
K + E+ ER E EE
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEE 82
Score = 37.4 bits (85), Expect = 0.060
Identities = 22/84 (26%), Positives = 44/84 (52%), Gaps = 6/84 (7%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKN------QKKK 627
T E+++ E E + +K K++R +K+ K + + +E++++ +KKK
Sbjct: 10 TEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKK 69
Query: 628 RDEEEEEASGLKEELIPEKLERVE 651
++EEE E +EE E+ E+ E
Sbjct: 70 KEEEEREEEEEEEEEEKEEEEKEE 93
Score = 33.5 bits (75), Expect = 0.87
Identities = 14/51 (27%), Positives = 32/51 (62%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKK 626
E +++E E +E +K ++R+ +KK + +EE + +++R++K +KK
Sbjct: 73 EEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123
Score = 31.6 bits (70), Expect = 3.3
Identities = 13/48 (27%), Positives = 29/48 (60%)
Query: 593 KKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKE 640
KK K++ ++ + EE + E+E ++K ++K++ +E+E+ KE
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKE 48
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 47.0 bits (110), Expect = 8e-05
Identities = 44/200 (22%), Positives = 88/200 (44%), Gaps = 15/200 (7%)
Query: 19 KCYEQ--KQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKK-EEAYEFVRKGLRN 75
+CY + K +C + ++ + A+H LA G +N L + E++ ++K +R
Sbjct: 764 RCYGRALKLMSTSNTWCDLGINYYRQAQH---LAETGSNMNDLKELLEKSLHCLKKAVRL 820
Query: 76 DVKSHVCWHVYGLLQ--RSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGY 133
D +H+ W+ G++ Y A C+ +++ ++ N +L +L + ++E
Sbjct: 821 DSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQA 880
Query: 134 RETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQV---PPNKIDYEYS 190
E L P+ WIG A+ + YD ++ FR T ++ + Y Y
Sbjct: 881 HEAFKMAQSLDPSYLMCWIGQALIAEAVGSYD----TMDLFRHTTELNMHTEGALGYAYW 936
Query: 191 ELILYQNQVMREADLLQESL 210
Q++ RE +L Q ++
Sbjct: 937 VCTTLQDKSNRETELYQYNI 956
Score = 31.2 bits (69), Expect = 4.3
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 52 KGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDK 111
+GL G+ +A ++ LR D K CW G S Y A+K + A +L+
Sbjct: 570 RGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNP 629
Query: 112 DNLQILRDLSLLQIQMRDLEGYRE--TRYQLL 141
+++ + ++ +Q + L Y+E +YQ++
Sbjct: 630 ESIYSVFKVAAIQ---QILGKYKEAVAQYQMI 658
Score = 30.4 bits (67), Expect = 7.4
Identities = 16/66 (24%), Positives = 31/66 (46%)
Query: 93 DKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWI 152
+K+Y EA+K + LK +K+N + + ++ + + + +L P Q +W
Sbjct: 19 NKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQ 78
Query: 153 GYAIAY 158
G A Y
Sbjct: 79 GLANLY 84
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 46.6 bits (109), Expect = 1e-04
Identities = 27/76 (35%), Positives = 47/76 (61%), Gaps = 3/76 (3%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKH--AERERQQKNQKKKRDEEEEEA 635
++QE E L +E +K L ++RR Q+ + +EER+ +RE +++ Q+ KR++EE
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 636 SGLKEELIPEKLERVE 651
LK E + E+LE+ E
Sbjct: 600 QRLKREEV-ERLEQEE 614
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/76 (30%), Positives = 44/76 (57%), Gaps = 1/76 (1%)
Query: 578 KQQEINSENLSAKELKKMLSKQ-RRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEAS 636
++QE+ + +EL++ + R Q+K + E ER++ E E Q+ ++K+R +E++ S
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 637 GLKEELIPEKLERVEN 652
LK + PEK V +
Sbjct: 1222 DLKWQWEPEKENAVRD 1237
Score = 38.9 bits (89), Expect = 0.021
Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 13/159 (8%)
Query: 503 DALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAI 562
D LK+ E ERH E Q R+ + R E RR +
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 563 EIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQ- 621
E LK + E QQ + SE +E ++ + + +++ +LE+ER+ +R+Q
Sbjct: 516 EQRLKRQEE---EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 622 --KNQKKKRDEE-------EEEASGLKEELIPEKLERVE 651
++Q KR+EE E+ L++ L E++ER+E
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Score = 38.1 bits (87), Expect = 0.035
Identities = 20/80 (25%), Positives = 41/80 (51%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEE 632
L E ++E + L ++E ++ +Q R +++ + E+ K E E + + + K+ EEE
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Query: 633 EEASGLKEELIPEKLERVEN 652
L EE + ER+++
Sbjct: 680 RREQELAEEEQEQARERIKS 699
Score = 37.7 bits (86), Expect = 0.046
Identities = 19/73 (26%), Positives = 41/73 (56%), Gaps = 1/73 (1%)
Query: 578 KQQEINSENLSAKELKKMLSKQ-RRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEAS 636
++Q++ E +E + +Q RR Q+ + +EE +H ++ Q++ +++ + E+EE
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 637 GLKEELIPEKLER 649
LK E E+ E+
Sbjct: 457 WLKREEETERHEQ 469
Score = 37.7 bits (86), Expect = 0.046
Identities = 21/85 (24%), Positives = 45/85 (52%), Gaps = 2/85 (2%)
Query: 568 LYDNPLTNES--KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQK 625
LY P E K+Q++ E + ++ ++R+ Q++ EEE+ E E+ + ++
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 626 KKRDEEEEEASGLKEELIPEKLERV 650
+KR +E E K++ + +K E++
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQL 973
Score = 37.4 bits (85), Expect = 0.060
Identities = 23/80 (28%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEAS- 636
+Q+E E +E ++ K+ + +++ L+ E + E++++ Q+ KRD+EEE
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 637 --GLKEELIPEKLERVENPL 654
L+EE E+ ER E L
Sbjct: 488 WLKLEEEERREQQERREQQL 507
Score = 37.4 bits (85), Expect = 0.060
Identities = 22/82 (26%), Positives = 49/82 (59%), Gaps = 10/82 (12%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQ--KKAKLEEERKH----AERERQQKNQKKKRDEE 631
+Q+E + L +E++++ ++RR Q K+ + EEER+ +E + +++ Q+ +R+++
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 632 EEEASGLK----EELIPEKLER 649
E LK EE + ++L+R
Sbjct: 653 ERREQRLKREEEEERLEQRLKR 674
Score = 37.4 bits (85), Expect = 0.060
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 7/99 (7%)
Query: 565 YLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRR-------AQKKAKLEEERKHAER 617
+LK E +QQ + +E ++ LS+Q R Q+ + E ERK E
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 618 ERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEE 656
E+Q + ++ ++ EEE+ +EE + ER LEE
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Score = 37.0 bits (84), Expect = 0.079
Identities = 23/94 (24%), Positives = 52/94 (55%), Gaps = 12/94 (12%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLE-----------EERKHAERERQQKNQKK 626
+Q+E + L +E ++ L ++ R++++ + E EE K E+ER+++ K+
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 627 KRDEEEEEASGLKEELIPEKLER-VENPLEEAVK 659
+++E ++ +EE ++L+R E LE+ +K
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Score = 37.0 bits (84), Expect = 0.079
Identities = 20/77 (25%), Positives = 44/77 (57%), Gaps = 3/77 (3%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHA---ERERQQKNQKKKRDEEE 632
E QQE +E ++ ++R+ +K KL+++ + E E++++ +++K+ EE
Sbjct: 934 EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE 993
Query: 633 EEASGLKEELIPEKLER 649
EE +E+L+ E+ E+
Sbjct: 994 EELQQEEEQLLREEREK 1010
Score = 36.6 bits (83), Expect = 0.10
Identities = 47/221 (21%), Positives = 90/221 (40%), Gaps = 21/221 (9%)
Query: 567 KLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQ---KN 623
KL L E +++E + L ++ L +++ +++ + EE R+ ER QQ +
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQ---QLRRKQEEERREQQEERREQQERREQQEERRE 336
Query: 624 QKKKRDEEEEEASGLKEELIPEKLE---RVENPLEEAVKFLIPLKNLVADNIDTHLLAFE 680
Q+ +R++EE L+ E E+ E R E E + L + L + L E
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE----QQLRRE 392
Query: 681 IYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKI 740
R+ + L Q ++R + E +R + H + QE ++
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE-------QERREQ 445
Query: 741 FVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQEK 781
+K++ E D+LKR + +H K D+ + +
Sbjct: 446 RLKREQEE-RRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Score = 36.6 bits (83), Expect = 0.10
Identities = 21/77 (27%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRD---EEE 632
E QQE +E ++ +R+ +K+ +L++E + RE +K ++++R+ EE
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113
Query: 633 EEASGLKEELIPEKLER 649
EE +E+L+ E+ E+
Sbjct: 1114 EELQQEEEQLLREEREK 1130
Score = 36.2 bits (82), Expect = 0.13
Identities = 24/106 (22%), Positives = 55/106 (51%), Gaps = 8/106 (7%)
Query: 549 RRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKL 608
RRH Y A+ A++ L+ L E ++E+ E + ++ + R ++ +
Sbjct: 885 RRHTLY---AKPALQEQLRKEQQLLQEE--EEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 609 EEERKHAERERQQKNQKKKRDEEEEEASGLKEELI---PEKLERVE 651
EE+ ERE++++ +++++ ++++ +E+L+ PEK R E
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Score = 36.2 bits (82), Expect = 0.13
Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 12/91 (13%)
Query: 576 ESKQQEINSENLSAKELKKM----LSKQRRAQKKAKLEEE---RKHAERERQQKNQKKKR 628
E QQE E L +E +K L +Q R +++ + EEE R+ E+ R+Q+ +++ R
Sbjct: 1114 EELQQE--EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 629 DEEE---EEASGLKEELIPEKLERVENPLEE 656
+EEE EE L+EE + ER EE
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Score = 36.2 bits (82), Expect = 0.13
Identities = 23/94 (24%), Positives = 49/94 (52%), Gaps = 3/94 (3%)
Query: 570 DNPLTNESKQQEINSENLSAKELKK-MLSKQRRAQKKAKLEEERKHAERE--RQQKNQKK 626
+ L E++Q+++ + K L++ L +R Q+ + E +RK E E RQ++ +++
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 627 KRDEEEEEASGLKEELIPEKLERVENPLEEAVKF 660
R +E + +E+L E+ E+ P + K+
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKY 1821
Score = 35.8 bits (81), Expect = 0.18
Identities = 22/82 (26%), Positives = 45/82 (54%), Gaps = 6/82 (7%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKH---AERERQQKNQKKKRDEEE 632
E QQE E ++ ++R+ +++ +L++E + ERE++++ + +++ EE
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 633 EEASGLKEELI---PEKLERVE 651
EE +E+L+ PEK R E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQE 1165
Score = 35.8 bits (81), Expect = 0.18
Identities = 21/76 (27%), Positives = 45/76 (59%), Gaps = 5/76 (6%)
Query: 578 KQQEINSENLSAK--ELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
++QE+ S+ K E ++ L +Q+R +K + E++ + ER +Q++ + ++ EEE+
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ- 1562
Query: 636 SGLKEELIPEKLERVE 651
L++E ++L R E
Sbjct: 1563 --LRQEREEQQLSRQE 1576
Score = 35.4 bits (80), Expect = 0.23
Identities = 23/80 (28%), Positives = 46/80 (57%), Gaps = 3/80 (3%)
Query: 578 KQQEINSENLSAKE-LKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEAS 636
++ E + LSA+ L++ +Q RA+++ + E+ E E++Q+ +++R E E+E
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR--RRQRREREKELQ 832
Query: 637 GLKEELIPEKLERVENPLEE 656
L+EE ++ ER + EE
Sbjct: 833 FLEEEEQLQRRERAQQLQEE 852
Score = 35.4 bits (80), Expect = 0.23
Identities = 26/118 (22%), Positives = 53/118 (44%), Gaps = 8/118 (6%)
Query: 545 EDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEIN------SENLSAKELKKMLSK 598
E+ +R + Y K + E + +L D+ L + QQ++ E +E ++ +
Sbjct: 1232 ENAVRDNKVYCKGREN--EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 599 QRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEE 656
R ++ +LE E + + R +K+Q++K+ EE + + K E L+E
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Score = 34.3 bits (77), Expect = 0.51
Identities = 20/84 (23%), Positives = 43/84 (51%), Gaps = 1/84 (1%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E Q+E +E ++ L K R + + + +EE + +R R+++ ++K++EE E
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 636 SGLKEELIPEKLERVENPLEEAVK 659
+ E E+ E+ E E+ ++
Sbjct: 318 QEERREQ-QERREQQEERREQQLR 340
Score = 34.3 bits (77), Expect = 0.51
Identities = 20/87 (22%), Positives = 47/87 (54%), Gaps = 13/87 (14%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQ-------KKKR 628
+ ++++ E +E +++L ++R +++ +LE + + E +Q++ Q K++R
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 629 DE------EEEEASGLKEELIPEKLER 649
E EEEE +E+L+ E+ E+
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEK 1190
Score = 33.9 bits (76), Expect = 0.67
Identities = 23/108 (21%), Positives = 49/108 (45%), Gaps = 3/108 (2%)
Query: 570 DNPLTNESKQ---QEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKK 626
D L + +Q +E +E K ++ + +++ L EER+ R+ ++ +K
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 627 KRDEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDT 674
K + ++EE L+EE +L+ E E + + L+ + +T
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Score = 33.9 bits (76), Expect = 0.67
Identities = 26/101 (25%), Positives = 50/101 (49%), Gaps = 10/101 (9%)
Query: 570 DNPLTNESKQQEINSENLSAKEL-------KKMLSKQRRAQKKAKLEEERKHAERERQ-- 620
+ PL + + ++ E L +E ++ L +Q R +K K E++ + ERE+Q
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 621 QKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKFL 661
Q +K R+EE++ + ++ E+ ++V E KFL
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ-ERERKFL 1449
Score = 33.5 bits (75), Expect = 0.87
Identities = 17/82 (20%), Positives = 44/82 (53%)
Query: 575 NESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEE 634
+E +Q +++ ++ ++ L + R Q++ + E + E+ R+Q+ +++K + EE
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 635 ASGLKEELIPEKLERVENPLEE 656
L+ ++L+ E+ L+E
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQE 858
Score = 33.1 bits (74), Expect = 1.1
Identities = 20/82 (24%), Positives = 42/82 (51%), Gaps = 2/82 (2%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQ--RRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
E +QQ + SE + +++ +Q RR Q+ + EEE + +R +++ ++++ E E
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 634 EASGLKEELIPEKLERVENPLE 655
E E I ++ + + LE
Sbjct: 688 EEQEQARERIKSRIPKWQWQLE 709
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 11/92 (11%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEE-----------RKHAERERQQKNQ 624
E QQE +E ++ +R+ +KK +L++E R+ ERERQ + +
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 625 KKKRDEEEEEASGLKEELIPEKLERVENPLEE 656
++ + EEE+ +E ++LER EE
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/102 (21%), Positives = 49/102 (48%), Gaps = 21/102 (20%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLE---------------------EERKH 614
+ ++++ E +E +++L ++R +++ +LE E+R+
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 615 AERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEE 656
ERERQ + +++ + EEE+ +E+ ++LER EE
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/88 (28%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E +QE + LS +E + + QK + E+ERK E E+Q + Q+ ++ +E
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEE--QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 636 SGLKEE--LIPEKLERVENPLEEAVKFL 661
+E+ L+ E+ E+ + E KFL
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFL 1646
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 11/102 (10%)
Query: 570 DNPLTNESKQQEINSENLSAK--ELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKK 627
+ L E ++Q++ + K E ++ L +Q R +K + E++ + E ER+ + +++
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 628 RDEEEEEASGL---------KEELIPEKLERVENPLEEAVKF 660
R E E+E +E+L PE+ E+ E KF
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Score = 32.7 bits (73), Expect = 1.5
Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 10/114 (8%)
Query: 531 RKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNP-LTNESKQQEINSENLSA 589
R+ L+ + RL+ LR + E LK + L E ++Q + E
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 590 KELKKMLSKQRRAQKKAKLEEER-----KHAERER----QQKNQKKKRDEEEEE 634
++ ++RR Q+ + +EER K E ER +++ Q+ KR+E EEE
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Score = 32.7 bits (73), Expect = 1.5
Identities = 17/74 (22%), Positives = 44/74 (59%), Gaps = 3/74 (4%)
Query: 579 QQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHA---ERERQQKNQKKKRDEEEEEA 635
QQE +E +++ ++R+ +++ +L++E + ERE +++ + +++ +EEE
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 636 SGLKEELIPEKLER 649
+E+L+ E+ E+
Sbjct: 1087 QQEEEQLLREEPEK 1100
Score = 32.7 bits (73), Expect = 1.5
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Query: 585 ENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIP 644
E L +E K+ + R++Q++ +L E + +R RQ+ ++K + EEE+ +EE
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR---EEEQLLQEREEQPL 1353
Query: 645 EKLERVENPLEEAVK 659
+ ER EE ++
Sbjct: 1354 RRQERDRKFREEELR 1368
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/82 (23%), Positives = 41/82 (50%), Gaps = 1/82 (1%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRD 629
+ L E ++Q+++ + K + K RR +++ K E+ + R+ Q+ +++RD
Sbjct: 1560 EEQLRQEREEQQLSRQERDRK-FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 630 EEEEEASGLKEELIPEKLERVE 651
+ E L +E ++L R E
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQE 1640
Score = 32.3 bits (72), Expect = 1.9
Identities = 17/82 (20%), Positives = 47/82 (57%), Gaps = 2/82 (2%)
Query: 576 ESKQQEINSENLSAKELK--KMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
E ++Q++ + + + K+ ++RR Q++ + ++ R+ E R+Q+ ++++ +E +
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 634 EASGLKEELIPEKLERVENPLE 655
+ +++L E+ ER E L+
Sbjct: 530 QRLRSEQQLRREQEERREQLLK 551
Score = 32.3 bits (72), Expect = 1.9
Identities = 20/84 (23%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEE 632
L + ++Q++ + ++ L ++ Q+ + E +RK E E+Q + Q+++R +
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711
Query: 633 EEASGLKEELIPEKLERVENPLEE 656
EE ++EL E+ R E L +
Sbjct: 1712 EEQQLRRQEL--ERKFREEEQLRQ 1733
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/87 (27%), Positives = 45/87 (51%), Gaps = 5/87 (5%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQ--QKNQKKK 627
+ L ++ ++ E L + ++ L +Q R +K + E++ + ERER+ Q+ Q+ +
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 628 RDEEE---EEASGLKEELIPEKLERVE 651
R E E E L++E E+L R E
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQE 1744
Score = 32.0 bits (71), Expect = 2.5
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 16/94 (17%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERE-----------RQQKNQKK 626
+Q+E + ++E K++L ++ R +K+ + E +RK E E R+Q+ +K
Sbjct: 1303 EQKEAKRRDRKSQEEKQLL-REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRK 1361
Query: 627 KRDEE----EEEASGLKEELIPEKLERVENPLEE 656
R+EE E+ L+EE + ER L+E
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Score = 32.0 bits (71), Expect = 2.5
Identities = 16/64 (25%), Positives = 33/64 (51%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
++Q++ E ++ L ++R Q+ + E +RK E E+Q + Q++ R E+E
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 638 LKEE 641
+ E
Sbjct: 1511 QEPE 1514
Score = 31.6 bits (70), Expect = 3.3
Identities = 15/74 (20%), Positives = 37/74 (50%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E ++ ++ ++ + ++ R +++ K EE + + ER+++ K++ EEE
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 636 SGLKEELIPEKLER 649
LK E E+ ++
Sbjct: 632 QLLKSEEQEERRQQ 645
Score = 31.6 bits (70), Expect = 3.3
Identities = 41/203 (20%), Positives = 87/203 (42%), Gaps = 11/203 (5%)
Query: 459 KEAEEMCSKFTREGTSAMENLNEMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEI 518
+E +E + RE ++ L E + Q + Q+L D L++ E R +
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEE----QLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 519 TDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESK 578
D ++ + RK L++ LR+ + E+ + + E +
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE--ELQREEREKRRRQEQE 927
Query: 579 QQEINSENLSAKE---LKKMLSKQRRAQKKAKLEEERKHAERERQQKNQK--KKRDEEEE 633
+Q E L +E L++ K+RR +++ + +++K ++E Q ++ K+R +E E
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 634 EASGLKEELIPEKLERVENPLEE 656
+ +EEL E+ + + E+
Sbjct: 988 KKYREEEELQQEEEQLLREEREK 1010
Score = 31.6 bits (70), Expect = 3.3
Identities = 22/84 (26%), Positives = 40/84 (47%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEE 632
L E ++ E L + ++ L +Q R +K + E + + ERE+Q ++ + ++ EE
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 633 EEASGLKEELIPEKLERVENPLEE 656
E+ EE + ER EE
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREE 1696
Score = 31.2 bits (69), Expect = 4.3
Identities = 18/87 (20%), Positives = 47/87 (54%), Gaps = 1/87 (1%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRD 629
D E +++ E + KE +K+ ++ + Q++ + EEE + + ERQ+ ++++ +
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-EEEEQLRKLERQELRRERQEE 293
Query: 630 EEEEEASGLKEELIPEKLERVENPLEE 656
E++++ +++L ++ E EE
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEE 320
Score = 31.2 bits (69), Expect = 4.3
Identities = 22/88 (25%), Positives = 43/88 (48%), Gaps = 8/88 (9%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEE---- 631
E + Q + E ++ K ++R Q+ + E ER E R+Q+ ++++ +EE
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 632 ----EEEASGLKEELIPEKLERVENPLE 655
EE+ +++L E+ ER E L+
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLK 660
Score = 31.2 bits (69), Expect = 4.3
Identities = 14/70 (20%), Positives = 37/70 (52%), Gaps = 1/70 (1%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEE 632
L +Q+E + L ++ ++ + +R +++ +LE+ K E E +++ Q+ +E+E
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR-EHEEERREQELAEEEQE 691
Query: 633 EEASGLKEEL 642
+ +K +
Sbjct: 692 QARERIKSRI 701
Score = 31.2 bits (69), Expect = 4.3
Identities = 22/88 (25%), Positives = 40/88 (45%), Gaps = 6/88 (6%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKK-- 627
+ L + QQ++ E + L ++R Q+ + E +RK E E Q + Q+++
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 628 ----RDEEEEEASGLKEELIPEKLERVE 651
RD + E L +E ++L R E
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Score = 31.2 bits (69), Expect = 4.3
Identities = 18/68 (26%), Positives = 39/68 (57%), Gaps = 6/68 (8%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E +Q ++ + + L++ +Q RA+++ +E+ + E+E Q+ ++K+R E E +
Sbjct: 1824 EEEQLQLEEQE---QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK- 1879
Query: 636 SGLKEELI 643
L+EE I
Sbjct: 1880 --LREEHI 1885
Score = 30.8 bits (68), Expect = 5.6
Identities = 22/85 (25%), Positives = 43/85 (50%), Gaps = 10/85 (11%)
Query: 567 KLYDNPLTNESKQQEINSEN--------LSAKELKKMLSKQRRAQKKAK--LEEERKHAE 616
+L P E +++++ +E L +E K+ +QRR ++K LEEE +
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 617 RERQQKNQKKKRDEEEEEASGLKEE 641
RER Q+ Q+++ +E++ +E
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQE 867
Score = 30.4 bits (67), Expect = 7.4
Identities = 29/135 (21%), Positives = 58/135 (42%), Gaps = 12/135 (8%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQK----KAKLEEERKHAERERQQKNQK 625
D E +Q + +E ++ + +Q R +K + +L +ER RE +Q Q+
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 626 KKRDE---EEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIY 682
++ + +E + L+EE + ER E+ ++ P + + + H
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ---- 1528
Query: 683 FRKGKFLLMLQSVKR 697
R+ KFL Q ++R
Sbjct: 1529 -RQRKFLQEEQQLRR 1542
Score = 30.4 bits (67), Expect = 7.4
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 570 DNPLTNESKQQEINSEN---LSAKELKKMLSKQRRAQKKAKLEEERKH-AERERQQKNQK 625
+ L E ++Q + E A+E K RR +++ EEE+K ERER+ + +
Sbjct: 1825 EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH 1884
Query: 626 KKRDEEEEE 634
+R ++EE+
Sbjct: 1885 IRRQQKEEQ 1893
Score = 30.0 bits (66), Expect = 9.6
Identities = 19/70 (27%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 582 INSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEE 641
++ E + + K+ L + RR ++ + E R E + +++KR E+E E + +E+
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 642 LIPEKLERVE 651
EK ER+E
Sbjct: 155 --SEKQERLE 162
Score = 30.0 bits (66), Expect = 9.6
Identities = 13/52 (25%), Positives = 31/52 (59%)
Query: 590 KELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEE 641
K ++ L +Q R +++ + EEE+ E + +++ +++++ EEEE K +
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Score = 30.0 bits (66), Expect = 9.6
Identities = 26/128 (20%), Positives = 59/128 (46%), Gaps = 3/128 (2%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRD 629
+ L E ++Q+++ + K L++ +R+ + + E+E + E ER+ ++++
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 630 EEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKFL 689
++ + L+EE + ER + ++ + + L + + L E R KF
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE---RDRKFR 1582
Query: 690 LMLQSVKR 697
L Q V+R
Sbjct: 1583 LEEQKVRR 1590
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 46.6 bits (109), Expect = 1e-04
Identities = 95/435 (21%), Positives = 187/435 (42%), Gaps = 64/435 (14%)
Query: 407 LIELFYMKAKIYKHIGNLKEAAKWMDEAQS----LDTADRFINSKCAKYMLRANMIKEAE 462
L ++ + K +I K + + KE + +E ++ L+ + + K + I+ E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 463 EMCSKFTREGTSAMENLNEMQCMWFQTECISAYQ--------RLGRYGDALKKCHEVERH 514
+ S+ RE + L+ + + FQ E + L R ++LK C ++
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK-CASMKMA 721
Query: 515 FFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLT 574
++ + + + K L+ ++LL+ + + + ++I + L
Sbjct: 722 QLQLENKELE-----SEKEQLKKGLELLKASF---KKTERLEVSYQGLDIENQRLQKTLE 773
Query: 575 NESKQ-QEINSE----NLSAKELKKMLSKQRRAQKKAK-LEEERKHAERERQQKNQKKKR 628
N +K+ Q++ SE + + L+K L + + + K+ + LE+E K E+E Q + KK+
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 629 DEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKF 688
E+E + + E+ LE E VK + NL +N L+ EI K
Sbjct: 834 LEKENKRLRQQAEIKDTTLE------ENNVK----IGNLEKEN---KTLSKEIGIYKESC 880
Query: 689 LLM-------LQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIF 741
+ + + VKRA L E L+ S+ + D+ + L+ E++KI
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLV--SEKLKTQQMNNDL--EKLTHELEKIG 936
Query: 742 VKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKS---RQEKAIAIATRLDETIK---- 794
+ K+ +E +T ++ L +K+ L KS ++EK A+ RL+E+
Sbjct: 937 LNKERLLHDE-----QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991
Query: 795 -DKDVKTLIKVSEAL 808
+++KT+ K EAL
Sbjct: 992 LRQELKTVKKNYEAL 1006
Score = 43.9 bits (102), Expect = 6e-04
Identities = 136/734 (18%), Positives = 297/734 (40%), Gaps = 139/734 (18%)
Query: 161 LKDYDMALKLLEEFRQTQQVPPNKIDYEYSEL---ILYQNQVMREADLLQESLEHIE--- 214
+KD + K+L E + +KI++E ++ + + + A+ L+ L H+E
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 215 -MYEKQI------CDKL-LVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEK 266
+ +K+I C+K+ +E+ E+ + +LK+ + FKNL + E LEK
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ-------LESLEK 694
Query: 267 ALQISTL-EERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPL 325
+ S L EE L++ + ++ +L L E +E + K L +
Sbjct: 695 --ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL--------- 743
Query: 326 FTTLKSLYYNTEKVSI-----------IQELVTNYEASLKTCDFFSPYENGEKEPPTTLL 374
LK+ + TE++ + +Q+ + N ++ + S ++ E E T
Sbjct: 744 ---LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE--SELQDLEMENQT--- 795
Query: 375 WVQYFLAQHFDKLGQYSLALDYI---NAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWM 431
L ++ ++L S L+ + N ++ + +E K ++ K L++ A+
Sbjct: 796 -----LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD--KKQLEKENKRLRQQAEIK 848
Query: 432 D--------EAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLNEMQ 483
D + +L+ ++ ++ + Y +KE E+ + + T ++ L
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL---- 904
Query: 484 CMWFQTECISAYQRLGRYGDALKKC-HEVER---------HFFEITDDQFDFHTYCMRKM 533
+ + + +S + + + L+K HE+E+ H + TDD++
Sbjct: 905 -VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES----- 958
Query: 534 TLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELK 593
+LE L++ + +A+E L+ N N+ +QE+ + + + LK
Sbjct: 959 ---------KLESTLKKSLEIKEEKIAALEARLEESTN--YNQQLRQELKTVKKNYEALK 1007
Query: 594 KMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENP 653
+ ++R Q + E ERE Q E E +K+ LI ++ER
Sbjct: 1008 QRQDEERMVQSSPPISGEDNKWERESQ---------ETTRELLKVKDRLI--EVERNNAT 1056
Query: 654 LE---EAVKFLIPLKNLVADNIDTHLLAFE---IYFRKGKFLLMLQSVKRAFAINSNNPW 707
L+ +A+K + +N+ +LA + + ++ L Q+ K ++ N
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 708 LHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLK----------RN 757
+ + ++ + S+L + V+ + ++DL+S + +K R
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVIKE-------REDLKSLYDSLIKDHEKLELLHERQ 1169
Query: 758 ATSLQHLLSGAKMMYFLDKSRQEKAIAIATRLDETIKDK----DVKTLIKVSEALLDGSF 813
A+ + L+S + K+ + + + R ++ +K K D++ ++KV + +
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1229
Query: 814 GNCSSQYEEYRMAC 827
N + EY+ C
Sbjct: 1230 KNHETVAAEYKKLC 1243
Score = 32.7 bits (73), Expect = 1.5
Identities = 38/178 (21%), Positives = 71/178 (39%), Gaps = 30/178 (16%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
T E + ++S +A ++ KM + +R KK ++ E E++ Q Q +D +E
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 634 EASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQ 693
+A + + +E + E +K L + + HL R+ +
Sbjct: 535 KAQ------LEKTIETLRENSERQIKIL--------EQENEHLNQTVSSLRQRS---QIS 577
Query: 694 SVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNE 751
+ R I N LHE ++ + SK+ E +K +KK+LE + E
Sbjct: 578 AEARVKDIEKENKILHE-------------SIKETSSKLSKIEFEKRQIKKELEHYKE 622
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 46.6 bits (109), Expect = 1e-04
Identities = 86/398 (21%), Positives = 162/398 (40%), Gaps = 64/398 (16%)
Query: 130 LEGYRETRYQLLQ----LRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKI 185
LEG + +L Q L P + A + LL + A+++ E + Q +I
Sbjct: 79 LEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQ-KDWEI 137
Query: 186 DYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASE 245
+ +Y Q + D L +L ++ ++ L + G+I L G L +A E
Sbjct: 138 SHNLGVCYIYLKQFNKAQDQLHNAL-NLNRHD-------LTYIMLGKIHLLEGDLDKAIE 189
Query: 246 VFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAIT--PRRLPLTLVPG 303
V+K ++ + EN E + L +L IY++ + A+T P L G
Sbjct: 190 VYKKAVEFSPEN------TELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG 243
Query: 304 ER------FRELMDKFLRVNFS-KGCPPLFTTLKSLYYNTEK-VSIIQELVTNYEASLKT 355
F + K+ V + PPL+ + ++ +K V+ I + LK
Sbjct: 244 SMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAI--------SCLKR 295
Query: 356 CDFFSPYENGEKEPPTTLLW-VQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMK 414
++ +P++ W + Y L + QY+ A +++AAI P + EL+ +
Sbjct: 296 ANYLAPFD-----------WKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLL 344
Query: 415 AKIYKHIGNLKEAAKWMDEAQSLDTADRFINSKCAKYML----RANMIKEAEEMCSKFTR 470
A ++ +++ A + EA LD + +N A + + N + + +EM K
Sbjct: 345 AVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKK--- 401
Query: 471 EGTSAMENLNEMQCMWFQTECISAYQRLG---RYGDAL 505
+ L + + F +E + Q+LG + G+AL
Sbjct: 402 -----VSLLKDNSSLEFDSEMVEMAQKLGAALQVGEAL 434
Score = 33.1 bits (74), Expect = 1.1
Identities = 34/163 (20%), Positives = 64/163 (39%), Gaps = 3/163 (1%)
Query: 83 WHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQ 142
W+ G+ KKY AI C + A L + +IL +L L+ + M+ +
Sbjct: 273 WNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAIN 332
Query: 143 LRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMRE 202
+P ++ A+A L+D + A + E + P ++ Y+ L+ Q +
Sbjct: 333 FQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNP-LVNLNYAVLLYNQGEKKNA 391
Query: 203 ADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASE 245
QE + + + + L + E+ KLG + E
Sbjct: 392 LAQYQEMEKKVSLLKDN--SSLEFDSEMVEMAQKLGAALQVGE 432
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 46.2 bits (108), Expect = 1e-04
Identities = 140/731 (19%), Positives = 273/731 (37%), Gaps = 137/731 (18%)
Query: 89 LQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEG--------YRETRYQL 140
LQ++ ++ DE ++ + L++ LQIQ + L+ + T L
Sbjct: 214 LQQARREKDETMREF----------LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL 263
Query: 141 LQLRPTQRASWIGYAIAYHLLKDYD-------MALKLLEEFRQTQQVPPNK-IDYEYSEL 192
LQ + HLL+DY M + L+E + ++ +K ++ E
Sbjct: 264 LQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE 323
Query: 193 ILYQNQVMREAD--LLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNL 250
I + ++ E + +++E + +E+ +K L+ E++ +I+ K +K N
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
Query: 251 IDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELM 310
+ ++ E+ Q+ E LQ Q I R T E+ R +
Sbjct: 384 KQKERQS------SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 311 DKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEKEPP 370
D+ Y + V + QEL+ + A ++ GE E
Sbjct: 438 DEM--------------------YGQQIVQMKQELIRQHMAQMEE---MKTRHKGEME-- 472
Query: 371 TTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKW 430
L + + D++ ++A++ +N + T + K K+ + +G + E K
Sbjct: 473 -NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS------QKEKLKEELGLILEE-KC 524
Query: 431 MDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLNEMQCMWFQTE 490
+ Q D + S+ + + RA +E + S +E+L + E
Sbjct: 525 ALQRQLEDLVEELSFSR--EQIQRARQTIAEQESKLNEAHKSLSTVEDL--------KAE 574
Query: 491 CISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYC-MRKMTLRAYVDLLRL----- 544
+SA + L+ HE E ++I + + + +M +L RL
Sbjct: 575 IVSASESRKE----LELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLL 630
Query: 545 -----------EDILRRHAFYFKAARSAIEIYLKLYDNPLTNE----------------S 577
ED+ H + + + I+ K + L NE +
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT 690
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
KQ ++ E K+L++ L + + ++ E +K E RQ++ +K ++E +E
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ- 749
Query: 638 LKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDT--HLLAFEIYFRKGKFLLMLQSV 695
LK EL+ ++++ EN L+E L +++ D T +L + + L+ L S+
Sbjct: 750 LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSI 809
Query: 696 KR-----------AFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSK---VLSQEMQKIF 741
K I N +C I+ ++ + N K V QE+Q+ +
Sbjct: 810 KSKSKDSVWEKEIEILIEENEDLKQQC-IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
Query: 742 -----VKKDLE 747
VK DLE
Sbjct: 869 ACLLKVKDDLE 879
Score = 33.9 bits (76), Expect = 0.67
Identities = 38/168 (22%), Positives = 81/168 (48%), Gaps = 15/168 (8%)
Query: 539 VDLLRLEDILRRHA----FYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKK 594
V+L + E ++ +A + + + +I +L L ++ QE+ +E +E ++
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 595 MLSKQRRAQKKAKLEEERKHAERERQQKNQK--KKRDEEEEEASGLKEELIPEKLERVEN 652
+LS+Q+ A K E E++ Q+ +K K++ E + +A ++++L ++++ +E
Sbjct: 1975 LLSRQKEAMK-----AEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDL-QKQVKALEI 2028
Query: 653 PLEEAVKFLIPL---KNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKR 697
+EE V I L KN ++ A E K + L Q++ R
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR 2076
Score = 31.2 bits (69), Expect = 4.3
Identities = 17/74 (22%), Positives = 40/74 (54%), Gaps = 3/74 (4%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
K ++++ + L ++ +++ + ++K+E+ ++ E +RQ Q K D E + G
Sbjct: 3382 KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ---QVYKLDLEGQRLQG 3438
Query: 638 LKEELIPEKLERVE 651
+ +E ++LER E
Sbjct: 3439 IMQEFQKQELEREE 3452
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 46.2 bits (108), Expect = 1e-04
Identities = 140/731 (19%), Positives = 273/731 (37%), Gaps = 137/731 (18%)
Query: 89 LQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEG--------YRETRYQL 140
LQ++ ++ DE ++ + L++ LQIQ + L+ + T L
Sbjct: 214 LQQARREKDETMREF----------LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL 263
Query: 141 LQLRPTQRASWIGYAIAYHLLKDYD-------MALKLLEEFRQTQQVPPNK-IDYEYSEL 192
LQ + HLL+DY M + L+E + ++ +K ++ E
Sbjct: 264 LQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE 323
Query: 193 ILYQNQVMREAD--LLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNL 250
I + ++ E + +++E + +E+ +K L+ E++ +I+ K +K N
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
Query: 251 IDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELM 310
+ ++ E+ Q+ E LQ Q I R T E+ R +
Sbjct: 384 KQKERQS------SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 311 DKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEKEPP 370
D+ Y + V + QEL+ + A ++ GE E
Sbjct: 438 DEM--------------------YGQQIVQMKQELIRQHMAQMEE---MKTRHKGEME-- 472
Query: 371 TTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKW 430
L + + D++ ++A++ +N + T + K K+ + +G + E K
Sbjct: 473 -NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS------QKEKLKEELGLILEE-KC 524
Query: 431 MDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLNEMQCMWFQTE 490
+ Q D + S+ + + RA +E + S +E+L + E
Sbjct: 525 ALQRQLEDLVEELSFSR--EQIQRARQTIAEQESKLNEAHKSLSTVEDL--------KAE 574
Query: 491 CISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYC-MRKMTLRAYVDLLRL----- 544
+SA + L+ HE E ++I + + + +M +L RL
Sbjct: 575 IVSASESRKE----LELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLL 630
Query: 545 -----------EDILRRHAFYFKAARSAIEIYLKLYDNPLTNE----------------S 577
ED+ H + + + I+ K + L NE +
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT 690
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
KQ ++ E K+L++ L + + ++ E +K E RQ++ +K ++E +E
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ- 749
Query: 638 LKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDT--HLLAFEIYFRKGKFLLMLQSV 695
LK EL+ ++++ EN L+E L +++ D T +L + + L+ L S+
Sbjct: 750 LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSI 809
Query: 696 KR-----------AFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSK---VLSQEMQKIF 741
K I N +C I+ ++ + N K V QE+Q+ +
Sbjct: 810 KSKSKDSVWEKEIEILIEENEDLKQQC-IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
Query: 742 -----VKKDLE 747
VK DLE
Sbjct: 869 ACLLKVKDDLE 879
Score = 33.9 bits (76), Expect = 0.67
Identities = 38/168 (22%), Positives = 81/168 (48%), Gaps = 15/168 (8%)
Query: 539 VDLLRLEDILRRHA----FYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKK 594
V+L + E ++ +A + + + +I +L L ++ QE+ +E +E ++
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 595 MLSKQRRAQKKAKLEEERKHAERERQQKNQK--KKRDEEEEEASGLKEELIPEKLERVEN 652
+LS+Q+ A K E E++ Q+ +K K++ E + +A ++++L ++++ +E
Sbjct: 1975 LLSRQKEAMK-----AEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDL-QKQVKALEI 2028
Query: 653 PLEEAVKFLIPL---KNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKR 697
+EE V I L KN ++ A E K + L Q++ R
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR 2076
Score = 31.2 bits (69), Expect = 4.3
Identities = 17/74 (22%), Positives = 40/74 (54%), Gaps = 3/74 (4%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
K ++++ + L ++ +++ + ++K+E+ ++ E +RQ Q K D E + G
Sbjct: 3374 KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ---QVYKLDLEGQRLQG 3430
Query: 638 LKEELIPEKLERVE 651
+ +E ++LER E
Sbjct: 3431 IMQEFQKQELEREE 3444
Score = 30.4 bits (67), Expect = 7.4
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 15/96 (15%)
Query: 190 SELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIK--GEILLKLG-RLKEASEV 246
SEL+L + Q+ R+ E +E +E +++ LLVE+ K G + K L+ +
Sbjct: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185
Query: 247 FKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEE 282
++ IDR K +I+ LEE+L+ + E
Sbjct: 2186 ERDAIDR------------KEKEITNLEEQLEQFRE 2209
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/82 (30%), Positives = 52/82 (63%), Gaps = 3/82 (3%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
KQ ++ +E +E +K+ + +RA+++AK ++E + +E++++ +++K ++E+ E
Sbjct: 346 KQLKLRAER---EEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQR 402
Query: 638 LKEELIPEKLERVENPLEEAVK 659
LKEE E+ E +E LEE K
Sbjct: 403 LKEERRKERQEALEAKLEEKRK 424
Score = 37.0 bits (84), Expect = 0.079
Identities = 18/56 (32%), Positives = 34/56 (60%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
K+++ E + LK+ K+R+ +AKLEE+RK E +R ++ +K+ + E+ E
Sbjct: 389 KREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAE 444
Score = 35.8 bits (81), Expect = 0.18
Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 9/93 (9%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEE- 631
L E+K+ + E KE +K L ++ R +K+ K E+E+ AE++R ++ ++K+R E
Sbjct: 360 LKEEAKRAK--EEAKKKKEEEKELKEKERREKREKDEKEK--AEKQRLKEERRKERQEAL 415
Query: 632 ----EEEASGLKEELIPEKLERVENPLEEAVKF 660
EE+ +E+ + E+ +R++ E +F
Sbjct: 416 EAKLEEKRKKEEEKRLREEEKRIKAEKAEITRF 448
Score = 33.5 bits (75), Expect = 0.87
Identities = 19/78 (24%), Positives = 39/78 (50%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E + +E K+ K+ KQR +++ K +E A+ E ++K +++KR EEE+
Sbjct: 378 EKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKR 437
Query: 636 SGLKEELIPEKLERVENP 653
++ I ++ + P
Sbjct: 438 IKAEKAEITRFFQKPKTP 455
Score = 32.7 bits (73), Expect = 1.5
Identities = 21/68 (30%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 590 KELKKMLSKQRRAQKKAKLEEERKHAERERQQ-KNQKKKRDEEEEEASGLKEELIPEKLE 648
K ++ Q R K+ KL ER+ E+ +++ K K++ +++EE LKE+ EK E
Sbjct: 332 KNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKRE 391
Query: 649 RVENPLEE 656
+ E E
Sbjct: 392 KDEKEKAE 399
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 45.8 bits (107), Expect = 2e-04
Identities = 94/435 (21%), Positives = 187/435 (42%), Gaps = 63/435 (14%)
Query: 407 LIELFYMKAKIYKHIGNLKEAAKWMDEAQS----LDTADRFINSKCAKYMLRANMIKEAE 462
L ++ + K +I K + + KE + +E ++ L+ + + K + I+ E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 463 EMCSKFTREGTSAMENLNEMQCMWFQTECISAYQ--------RLGRYGDALKKCHEVERH 514
+ S+ RE + L+ + + FQ E + L R ++LK C ++
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK-CASMKMA 721
Query: 515 FFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLT 574
++ + + + K L+ ++LL+ + + + ++I + L
Sbjct: 722 QLQLENKELE-----SEKEQLKKGLELLKASF---KKTERLEVSYQGLDIENQRLQKTLE 773
Query: 575 NESKQ-QEINSE----NLSAKELKKMLSKQRRAQKKAK-LEEERKHAERERQQKNQKKKR 628
N +K+ Q++ SE + + L+K L + + + K+ + LE+E K E+E Q + KK+
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 629 DEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKF 688
E+E + + E+ LE E VK + NL +N L+ EI K
Sbjct: 834 LEKENKRLRQQAEIKDTTLE------ENNVK----IGNLEKEN---KTLSKEIGIYKESC 880
Query: 689 LLM-------LQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIF 741
+ + + VKRA L E L+ S+ + D+ + L+ E++KI
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLV--SEKLKTQQMNNDL--EKLTHELEKIG 936
Query: 742 VKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKS---RQEKAIAIATRLDETIK---- 794
+ K+ +E ++ ++ L +K+ L KS ++EK A+ RL+E+
Sbjct: 937 LNKERLLHDE----QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992
Query: 795 -DKDVKTLIKVSEAL 808
+++KT+ K EAL
Sbjct: 993 LRQELKTVKKNYEAL 1007
Score = 43.5 bits (101), Expect = 8e-04
Identities = 138/734 (18%), Positives = 298/734 (40%), Gaps = 138/734 (18%)
Query: 161 LKDYDMALKLLEEFRQTQQVPPNKIDYEYSEL---ILYQNQVMREADLLQESLEHIE--- 214
+KD + K+L E + +KI++E ++ + + + A+ L+ L H+E
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 215 -MYEKQI------CDKL-LVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEK 266
+ +K+I C+K+ +E+ E+ + +LK+ + FKNL + E LEK
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ-------LESLEK 694
Query: 267 ALQISTL-EERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPL 325
+ S L EE L++ + ++ +L L E +E + K L +
Sbjct: 695 --ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL--------- 743
Query: 326 FTTLKSLYYNTEKVSI-----------IQELVTNYEASLKTCDFFSPYENGEKEPPTTLL 374
LK+ + TE++ + +Q+ + N ++ + S ++ E E T
Sbjct: 744 ---LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE--SELQDLEMENQT--- 795
Query: 375 WVQYFLAQHFDKLGQYSLALDYI---NAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWM 431
L ++ ++L S L+ + N ++ + +E K ++ K L++ A+
Sbjct: 796 -----LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD--KKQLEKENKRLRQQAEIK 848
Query: 432 D--------EAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLNEMQ 483
D + +L+ ++ ++ + Y +KE E+ + + T ++ L
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL---- 904
Query: 484 CMWFQTECISAYQRLGRYGDALKKC-HEVER---------HFFEITDDQFDFHTYCMRKM 533
+ + + +S + + + L+K HE+E+ H + TDD R
Sbjct: 905 -VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDS--------RYK 955
Query: 534 TLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELK 593
L + +LE L++ + +A+E L+ N N+ +QE+ + + + LK
Sbjct: 956 LLES-----KLESTLKKSLEIKEEKIAALEARLEESTN--YNQQLRQELKTVKKNYEALK 1008
Query: 594 KMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENP 653
+ ++R Q + E ERE Q E E +K+ LI ++ER
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQ---------ETTRELLKVKDRLI--EVERNNAT 1057
Query: 654 LE---EAVKFLIPLKNLVADNIDTHLLAFE---IYFRKGKFLLMLQSVKRAFAINSNNPW 707
L+ +A+K + +N+ +LA + + ++ L Q+ K ++ N
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 708 LHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLK----------RN 757
+ + ++ + S+L + V+ + ++DL+S + +K R
Sbjct: 1118 STSLMNQNAQLLIQQSSLENENESVIKE-------REDLKSLYDSLIKDHEKLELLHERQ 1170
Query: 758 ATSLQHLLSGAKMMYFLDKSRQEKAIAIATRLDETIKDK----DVKTLIKVSEALLDGSF 813
A+ + L+S + K+ + + + R ++ +K K D++ ++KV + +
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 814 GNCSSQYEEYRMAC 827
N + EY+ C
Sbjct: 1231 KNHETVAAEYKKLC 1244
Score = 32.7 bits (73), Expect = 1.5
Identities = 38/178 (21%), Positives = 71/178 (39%), Gaps = 30/178 (16%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
T E + ++S +A ++ KM + +R KK ++ E E++ Q Q +D +E
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 634 EASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQ 693
+A + + +E + E +K L + + HL R+ +
Sbjct: 535 KAQ------LEKTIETLRENSERQIKIL--------EQENEHLNQTVSSLRQRS---QIS 577
Query: 694 SVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNE 751
+ R I N LHE ++ + SK+ E +K +KK+LE + E
Sbjct: 578 AEARVKDIEKENKILHE-------------SIKETSSKLSKIEFEKRQIKKELEHYKE 622
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 45.1 bits (105), Expect = 3e-04
Identities = 28/85 (32%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
+ ++++ + KEL+K KQR +K+ K E+E K ER+++++ + +K E+E+E
Sbjct: 529 KEREKDRERQQEKEKELEKEQEKQREMEKERKQEKE-KELERQKEKEKELQKMKEQEKEC 587
Query: 636 SGLKE-ELIPEKLERVENPLEEAVK 659
KE E + EK+E E LE V+
Sbjct: 588 ELEKEREKLEEKIEPREPNLEPMVE 612
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/87 (27%), Positives = 52/87 (59%), Gaps = 5/87 (5%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLE-EERKHAERERQQKNQKKK----RDEEE 632
+++E+ E +E ++ ++R+ +K+ +LE E+ K E E+++K +K+K + E+E
Sbjct: 515 REKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKE 574
Query: 633 EEASGLKEELIPEKLERVENPLEEAVK 659
+E +KE+ +LE+ LEE ++
Sbjct: 575 KELQKMKEQEKECELEKEREKLEEKIE 601
Score = 40.4 bits (93), Expect = 0.007
Identities = 21/72 (29%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 575 NESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEE 634
+ +QQE E +E ++ + K+R+ +K+ +LE + K E+E Q+ +++K E E+E
Sbjct: 534 DRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQ-KEKEKELQKMKEQEKECELEKE 592
Query: 635 ASGLKEELIPEK 646
L+E++ P +
Sbjct: 593 REKLEEKIEPRE 604
Score = 35.8 bits (81), Expect = 0.18
Identities = 22/68 (32%), Positives = 38/68 (55%), Gaps = 2/68 (2%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAER--ERQQKNQKKKRDEEEE 633
+ ++QE E KE +K L K + +K+ +LE+ER+ E E ++ N + +++E
Sbjct: 557 KERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQES 616
Query: 634 EASGLKEE 641
E S KEE
Sbjct: 617 ENSCNKEE 624
Score = 35.4 bits (80), Expect = 0.23
Identities = 25/90 (27%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 566 LKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQK 625
LK D L KQ + E + +E +K +++ +K+ + E E K E++R+++ +K
Sbjct: 485 LKRLDEKLGILEKQP--SPEEIREREREKEREREKELEKEQEQERE-KEREKDRERQQEK 541
Query: 626 KKRDEEEEEASGLKEELIPEKLERVENPLE 655
+K E+E+E + E+ E+ + E LE
Sbjct: 542 EKELEKEQEK---QREMEKERKQEKEKELE 568
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/81 (27%), Positives = 45/81 (55%), Gaps = 2/81 (2%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E ++ E + A++LK++ K +K+ EE R+ ERE++++ +K+ E+E+E
Sbjct: 469 EERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRER-EREKEREREKELEKEQEQER 527
Query: 636 SGLKEELIPEKLERVENPLEE 656
+E+ E+ + E LE+
Sbjct: 528 EKEREK-DRERQQEKEKELEK 547
>gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 170
Score = 44.7 bits (104), Expect = 4e-04
Identities = 21/74 (28%), Positives = 48/74 (64%), Gaps = 2/74 (2%)
Query: 564 IYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKN 623
++L L+ P E K++E E K+ KK K+++ +KK K ++++K +R+R++K
Sbjct: 92 LHLPLHGLPQREEKKEKE--KEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKR 149
Query: 624 QKKKRDEEEEEASG 637
++KK+ +++++ +G
Sbjct: 150 KRKKKRKKKKKKTG 163
Score = 35.0 bits (79), Expect = 0.30
Identities = 15/66 (22%), Positives = 41/66 (62%)
Query: 587 LSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEK 646
L +E KK K+++ +KK K ++++K ++++++K +KKK+ + + + +++ +K
Sbjct: 99 LPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKK 158
Query: 647 LERVEN 652
++ N
Sbjct: 159 KKKTGN 164
>gi|4827046 U2 small nuclear RNA auxiliary factor 1-like 2 [Homo
sapiens]
Length = 482
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/92 (27%), Positives = 52/92 (56%), Gaps = 4/92 (4%)
Query: 576 ESKQQEINSENL----SAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEE 631
E ++Q ++ E L A+E ++ ++ A KK + E+ERK E+ +Q+ ++++ +E+
Sbjct: 65 ERERQRLHEEWLLREQKAQEEFRIKKEKEEAAKKRQEEQERKLKEQWEEQQRKEREEEEQ 124
Query: 632 EEEASGLKEELIPEKLERVENPLEEAVKFLIP 663
+ + KEE + + L++ EN LE + P
Sbjct: 125 KRQEKKEKEEALQKMLDQAENELENGTTWQNP 156
Score = 32.3 bits (72), Expect = 1.9
Identities = 20/90 (22%), Positives = 48/90 (53%), Gaps = 2/90 (2%)
Query: 567 KLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKK 626
+L D+ L+ + ++++ E +E K + +++R ++ L E++ E +++ ++
Sbjct: 36 RLRDSGLSQKEEEEDTFIEEQQLEEEKLLERERQRLHEEWLLREQKAQEEFRIKKEKEEA 95
Query: 627 KRDEEEEEASGLKEELIPEKLERVENPLEE 656
+ +EE+ LKE+ E+ +R E EE
Sbjct: 96 AKKRQEEQERKLKEQW--EEQQRKEREEEE 123
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 43.9 bits (102), Expect = 6e-04
Identities = 37/162 (22%), Positives = 73/162 (45%), Gaps = 21/162 (12%)
Query: 504 ALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIE 563
A +K H + +QF CMR Y+ + +++L++ +E
Sbjct: 1365 AFRKGHVKVVQYLVKEVNQFPSDIECMR------YIATITDKELLKK-------CHQCVE 1411
Query: 564 IYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKN 623
+K D +K I + L ++ ++ KQ A K+ K +E+RK ++K
Sbjct: 1412 TIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRK------KKKE 1465
Query: 624 QKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLK 665
++K++ EE+EE + +PE + EN +E V+ +P++
Sbjct: 1466 EQKRKQEEDEENKPKENSELPEDEDEEEN--DEDVEQEVPIE 1505
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 43.9 bits (102), Expect = 6e-04
Identities = 37/162 (22%), Positives = 73/162 (45%), Gaps = 21/162 (12%)
Query: 504 ALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIE 563
A +K H + +QF CMR Y+ + +++L++ +E
Sbjct: 1365 AFRKGHVKVVQYLVKEVNQFPSDIECMR------YIATITDKELLKK-------CHQCVE 1411
Query: 564 IYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKN 623
+K D +K I + L ++ ++ KQ A K+ K +E+RK ++K
Sbjct: 1412 TIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRK------KKKE 1465
Query: 624 QKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLK 665
++K++ EE+EE + +PE + EN +E V+ +P++
Sbjct: 1466 EQKRKQEEDEENKPKENSELPEDEDEEEN--DEDVEQEVPIE 1505
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 43.5 bits (101), Expect = 8e-04
Identities = 25/87 (28%), Positives = 43/87 (49%)
Query: 567 KLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKK 626
+L D E+ +++ E +E+++ L + A+L+ + AER RQ + +++
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580
Query: 627 KRDEEEEEASGLKEELIPEKLERVENP 653
EEEEE KEE E +E E P
Sbjct: 581 PESEEEEEEKQEKEEKREEPMEEEEEP 607
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEER-KHAERERQQKNQK-KKRDEE 631
++ +K + + E +E ++ ++R +++ + E ER + ERER+++ +K KKRD E
Sbjct: 375 SDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDRE 434
Query: 632 EEEASGLKEELIPEKLERVENPLEEAVK 659
E+E + + KL E +E +K
Sbjct: 435 EDEEDAYERRKLERKLREKEAAYQERLK 462
Score = 37.4 bits (85), Expect = 0.060
Identities = 18/68 (26%), Positives = 41/68 (60%), Gaps = 2/68 (2%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAK--LEEERKHAERERQQKNQKKKRDEEEE 633
E K+ I+ E ++ K L +++ ++K + +E+ER+ ERER+++ ++++R+ E E
Sbjct: 271 EDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERE 330
Query: 634 EASGLKEE 641
++E
Sbjct: 331 REREREKE 338
Score = 36.6 bits (83), Expect = 0.10
Identities = 16/63 (25%), Positives = 38/63 (60%), Gaps = 1/63 (1%)
Query: 579 QQEINSENLSAKELKKMLSKQRRAQK-KAKLEEERKHAERERQQKNQKKKRDEEEEEASG 637
+ E + +L ++E+ K ++ ++ K K E+ER+ E+ER+++ ++++R+ E E
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
Query: 638 LKE 640
+E
Sbjct: 328 ERE 330
Score = 36.2 bits (82), Expect = 0.13
Identities = 16/61 (26%), Positives = 37/61 (60%), Gaps = 3/61 (4%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEE 633
T++ ++E + +E++K ++R +++ + E ER+ ERER+++ +++K E E
Sbjct: 287 THKKLEEEKGKKEKERQEIEK---ERRERERERERERERREREREREREREREKEKERER 343
Query: 634 E 634
E
Sbjct: 344 E 344
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/55 (38%), Positives = 32/55 (58%), Gaps = 1/55 (1%)
Query: 591 ELKKMLSK-QRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIP 644
EL++M + +RR Q + K E E + E E+Q+K +K++ EEEE K L P
Sbjct: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKP 615
Score = 33.5 bits (75), Expect = 0.87
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 2/85 (2%)
Query: 572 PLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEE 631
PL + I E + + +SK R KK LEEE+ E+ERQ+ ++++ E
Sbjct: 257 PLITKEDINAIEMEEDKRDLISREISKFRDTHKK--LEEEKGKKEKERQEIEKERRERER 314
Query: 632 EEEASGLKEELIPEKLERVENPLEE 656
E E + E E+ E E+
Sbjct: 315 ERERERERREREREREREREREKEK 339
Score = 31.2 bits (69), Expect = 4.3
Identities = 14/61 (22%), Positives = 37/61 (60%), Gaps = 3/61 (4%)
Query: 580 QEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLK 639
+++ E ++ ++ + K+RR +++ E ER+ RER+++ ++++ E+E+E +
Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERER---ERERERERREREREREREREREKEKERERER 345
Query: 640 E 640
E
Sbjct: 346 E 346
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 43.5 bits (101), Expect = 8e-04
Identities = 22/88 (25%), Positives = 49/88 (55%), Gaps = 1/88 (1%)
Query: 570 DNPLTNESKQ-QEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKR 628
D P S Q E+ SE ++E++ +L + + + + EEE + E ER+++ +++
Sbjct: 2207 DKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEE 2266
Query: 629 DEEEEEASGLKEELIPEKLERVENPLEE 656
+E +EE G ++++ E+ E+ + E+
Sbjct: 2267 EERKEEEEGEEKQVEKEEEEKKKKKKEK 2294
Score = 40.4 bits (93), Expect = 0.007
Identities = 20/71 (28%), Positives = 43/71 (60%)
Query: 585 ENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIP 644
E+LS++E ++ ++ R +++ + EEE + E E ++K +K+ +E++++ K+E +
Sbjct: 2241 ESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQ 2300
Query: 645 EKLERVENPLE 655
EK E E E
Sbjct: 2301 EKEEVFEEKEE 2311
Score = 40.0 bits (92), Expect = 0.009
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 568 LYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKK 627
L D ES E E +E ++ ++ ++K + E E K E+E ++K +KKK
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
Query: 628 RDEEEEEASGLKEELIPEKLE 648
++EE KEE+ EK E
Sbjct: 2293 EKKKEEVQE--KEEVFEEKEE 2311
Score = 39.7 bits (91), Expect = 0.012
Identities = 65/280 (23%), Positives = 116/280 (41%), Gaps = 48/280 (17%)
Query: 570 DNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKL--EEERKHAERER-------- 619
+ L E ++ E + E LS KE + + + ++K KL EEE +RE+
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKL 1770
Query: 620 --------QQKNQ----KKKRDEEEEEASGLKEELIPEKL------ERVENPLEEAVK-- 659
Q+K + K+K EEEE +E+LI +K+ ER N +EE K
Sbjct: 1771 AQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNK 1830
Query: 660 -FLIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKS 718
L KNL + + ++ RK L + + + + L++
Sbjct: 1831 MILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHS----------KKQLVQVKNK 1880
Query: 719 VSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSL---QHLLSGAKMMYFLD 775
+ + + V + L+QE + + KK+ + E L + SL Q L+ KM L+
Sbjct: 1881 LGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE 1940
Query: 776 KSRQEKAIAIATRLDETIKDK----DVKTLIKVSEALLDG 811
K+ + + LD ++K ++K L + L++G
Sbjct: 1941 KAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG 1980
Score = 38.9 bits (89), Expect = 0.021
Identities = 16/74 (21%), Positives = 46/74 (62%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEE 632
L++E +++ E +E+++ +++ ++ + + E++ E+++++K +KK+ +E+
Sbjct: 2243 LSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEK 2302
Query: 633 EEASGLKEELIPEK 646
EE KEE++ E+
Sbjct: 2303 EEVFEEKEEIMSEE 2316
Score = 37.7 bits (86), Expect = 0.046
Identities = 43/211 (20%), Positives = 95/211 (45%), Gaps = 13/211 (6%)
Query: 453 LRANMIKEAEEMCSKFTREGTSAMENLNEMQCMWFQTECISAYQRLGRYGDALKKCHEVE 512
++ M KE +M S+ E + E + + + E ++Q + D K+ H
Sbjct: 1416 IKREMTKEERDM-SEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGET 1474
Query: 513 RHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNP 572
R ++ ++++ + +A L E++L+ + E + ++++N
Sbjct: 1475 RKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDK------KLKWEEWKQVWENM 1528
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAK----LEEERKHAERERQQKNQKKKR 628
L+++SK+Q+ E E + + + Q+ + ++EE K A R++ +KKR
Sbjct: 1529 LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKR 1588
Query: 629 DEEEEEASGLKEELIPE--KLERVENPLEEA 657
+EE + + +E+L E +L + E L +A
Sbjct: 1589 AQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
Score = 37.0 bits (84), Expect = 0.079
Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 9/91 (9%)
Query: 575 NESKQQEINSENLSA--KELKKMLSKQRRAQKKAKLEEER-------KHAERERQQKNQK 625
+E + +E SE + + EL+K S +++ + EEER + ER+ +++ ++
Sbjct: 2218 DEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEE 2277
Query: 626 KKRDEEEEEASGLKEELIPEKLERVENPLEE 656
K+ ++EEEE K+E E+++ E EE
Sbjct: 2278 KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
Score = 36.6 bits (83), Expect = 0.10
Identities = 63/239 (26%), Positives = 102/239 (42%), Gaps = 28/239 (11%)
Query: 585 ENLSAKELKKMLSKQRRAQKKAKLE---EERKHAERERQQKNQK----KKRDEEEEEASG 637
E L +E ++ AQ+ +LE EE E E Q+ K KK+ EEEEA
Sbjct: 1698 EELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALA 1757
Query: 638 LKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKFLL---MLQS 694
+ EKL E L + + LI K +A + + E RK + L+ M +
Sbjct: 1758 WQR----EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLA 1813
Query: 695 VKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFL 754
KR INS +I + K NL K L+QE +K+ +K+ +N++ L
Sbjct: 1814 QKRERWINSMEELTKNKMILYQK-----KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERL 1867
Query: 755 KRNATSLQHLLSGAKMMYFL-----DKSRQEKAIAIATRLDETIKDKDVKTLIKVSEAL 808
+ L + + M + +K QEK I + E + + + K L++V ++L
Sbjct: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK--EKLAETE-KKLVQVEDSL 1923
Score = 36.2 bits (82), Expect = 0.13
Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 15/86 (17%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQ---RRAQKKAKLEEERKHAERERQQKNQKKKR---- 628
E +++E+ E KE ++ KQ +KK K +E++K +E+++ ++K+
Sbjct: 2256 EREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE 2315
Query: 629 --------DEEEEEASGLKEELIPEK 646
+EEEEE+ L+EE+ EK
Sbjct: 2316 EETESLSDEEEEEESCSLEEEVDREK 2341
Score = 34.3 bits (77), Expect = 0.51
Identities = 118/609 (19%), Positives = 238/609 (39%), Gaps = 94/609 (15%)
Query: 88 LLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPT- 146
L QR +K EA K + KL K ++ R+ L + L + Q ++ P
Sbjct: 1644 LAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
Query: 147 -QRASWIGYAIAYHLLK-DYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMREAD 204
Q W +A L + ++DM EE ++ +++ E +L+ + ++ E +
Sbjct: 1704 EQNLDWQEKELAQELEELEWDM-----EELSWKEE----ELNQEEGKLVEEKKKLAEEEE 1754
Query: 205 LLQESLEHIEMYEKQIC--DKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYE 262
L E + E ++ ++LL++E + KL + KE + + R E
Sbjct: 1755 ALAWQREKLSEEETKLAQEEELLIQEKE-----KLAQHKEKMPEEEERLGRKREQL---- 1805
Query: 263 GLEKALQISTLEER-LQIYEEISK------------QHPKAITPRRLPLTLVPGERFREL 309
+EK ++++ ER + EE++K Q K + + L +R L
Sbjct: 1806 -IEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA----QRKENL 1860
Query: 310 MDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEK-- 367
+ R+ SK K L K+ + +++ E L T + + + EK
Sbjct: 1861 LYNKERLTHSK---------KQLVQVKNKLGMFNKILAQVEEKL-TQEKETVIKKKEKLA 1910
Query: 368 EPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEA 427
E L+ V+ LA+ +KL Q + L A + K ++ + KE
Sbjct: 1911 ETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQG----------KKRLRGELDIAKE- 1959
Query: 428 AKWMDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLNEMQCMWF 487
++ +N + + + E +E SK TS + +++ F
Sbjct: 1960 -------------EKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
Query: 488 QTECISAYQRLGRYGDALKKCHEVE--RHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLE 545
+ + +S +++ + D + E E + E T Q F RK+ + + + E
Sbjct: 2007 ERK-LSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIF-VQGQRKLAKASRKLIKKRE 2064
Query: 546 DILRRHAFYFKAARSAIEIY-----LKLYDNPLTNESKQQEINSENLSAKELKKMLSKQR 600
+ + A K ++ ++ L + +T + + LS ++ K + +
Sbjct: 2065 SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWD 2124
Query: 601 RAQKKAKL--------EEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVEN 652
++K+++L ++RK A + R+ N+++K EEE + + E+I + E
Sbjct: 2125 FSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184
Query: 653 PLEEAVKFL 661
EE + FL
Sbjct: 2185 EEEEVIPFL 2193
Score = 32.3 bits (72), Expect = 1.9
Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 11/111 (9%)
Query: 550 RHAFYFKAARSAIE---IYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKA 606
+ A + K R +IE + +K +D +E + + E A++ +K+ +K RR K
Sbjct: 2101 KRALFVKERRLSIEQSKLDIKEWD---FSEKRSELTKDEKKLARKQRKLANKMRRMINK- 2156
Query: 607 KLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEA 657
EE+ E + +K+ + D+EEE G++EE + L+R +EA
Sbjct: 2157 --EEKMTEEESKLARKHSEVILDDEEE--GGIEEEEVIPFLKRRWRKRKEA 2203
Score = 30.0 bits (66), Expect = 9.6
Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 22/103 (21%)
Query: 576 ESKQQEINSENLSAKE--------LKKMLSKQRRAQKKAKL--------EEERKHAERER 619
E K+Q++ E +E K+ ++++RAQ++ KL +EER+ A+ ER
Sbjct: 1555 EEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEER 1614
Query: 620 Q--QKNQKKKRDEEE----EEASGLKEELIPEKLERVENPLEE 656
+ Q K +D+ E E KEE + ++ E++ E+
Sbjct: 1615 KLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEK 1657
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/82 (30%), Positives = 48/82 (58%), Gaps = 6/82 (7%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDE----EEE 633
+++ E L A+E ++ L Q +A+++ +LEE+ + ER RQ++ + + +E EEE
Sbjct: 305 RREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEE 364
Query: 634 EASGLKEELIPEKLERVENPLE 655
EA G +E + ++ V+ P E
Sbjct: 365 EAEGWEE--LEQQEAEVQGPPE 384
Score = 32.3 bits (72), Expect = 1.9
Identities = 21/88 (23%), Positives = 41/88 (46%), Gaps = 8/88 (9%)
Query: 572 PLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKK----- 626
PL E +E +L A + ++R +++ + EEER+ + + Q + +++
Sbjct: 280 PLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDA 339
Query: 627 ---KRDEEEEEASGLKEELIPEKLERVE 651
+R +EEE EEL ++ E E
Sbjct: 340 RLEERRRQEEEEGRCAEELKRQEEEEAE 367
Score = 31.6 bits (70), Expect = 3.3
Identities = 25/89 (28%), Positives = 44/89 (49%), Gaps = 8/89 (8%)
Query: 570 DNPLTNESKQQEINSENLSAK------ELKKMLSKQR-RAQKKAKLEEERKHAERERQQK 622
D P +E + ++SE + EL+ +Q+ A +K +LEE+R A ER+
Sbjct: 203 DKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQA-LERRLW 261
Query: 623 NQKKKRDEEEEEASGLKEELIPEKLERVE 651
+ ++++ EEE G + L E+ R E
Sbjct: 262 EENRRQELLEEEGEGQEPPLEAERAPREE 290
Score = 30.8 bits (68), Expect = 5.6
Identities = 24/96 (25%), Positives = 45/96 (46%), Gaps = 10/96 (10%)
Query: 566 LKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLE-------EERKHAERE 618
L+ + L E+++QE+ E +E + R +++ LE E R+ ERE
Sbjct: 253 LQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERE 312
Query: 619 RQQKNQKKKR---DEEEEEASGLKEELIPEKLERVE 651
R + ++++R + EE L+E+ E+ R E
Sbjct: 313 RLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQE 348
>gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]
Length = 843
Score = 43.1 bits (100), Expect = 0.001
Identities = 42/217 (19%), Positives = 93/217 (42%), Gaps = 27/217 (12%)
Query: 88 LLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQ 147
LL +K++ E ++C+ ++K++ L + L + + D +G + + + L P
Sbjct: 535 LLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDN 594
Query: 148 RASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMREADLLQ 207
+W + +Y LK A + L+E K +YE+ + +++N ++ D+ +
Sbjct: 595 AEAWNNLSTSYIRLKQKVKAFRTLQE--------ALKCNYEHWQ--IWENYILTSTDVGE 644
Query: 208 ES---------LEHIEMYEKQICDKLLVEEI-------KGEILLKL-GRLKEASEVFKNL 250
S L+ + Y+ K+LV + G++ L G+L+E +
Sbjct: 645 FSEAIKAYHRLLDLRDKYKDVQVLKILVRAVIDGMTDRSGDVATGLKGKLQELFGRVTSR 704
Query: 251 IDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQH 287
+ + E W Y + Q +E + ++ +SK +
Sbjct: 705 VTNDGEIWRLYAHVYGNGQSEKPDENEKAFQCLSKAY 741
Score = 33.9 bits (76), Expect = 0.67
Identities = 35/156 (22%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 102 CYRNALKLDK-DNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHL 160
CY A +L + + + R +LL ++ ++ + E + +++ P Q W AY
Sbjct: 514 CYDKAWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLA 573
Query: 161 LKDYDMALKLLEEFRQTQQVPPNKID--YEYSELILYQNQVMREADLLQESL----EHIE 214
L+DY + K F++ + P+ + S + Q ++ LQE+L EH +
Sbjct: 574 LEDYQGSAK---AFQRCVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQ 630
Query: 215 MYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNL 250
++E I V E E + RL + + +K++
Sbjct: 631 IWENYILTSTDVGEF-SEAIKAYHRLLDLRDKYKDV 665
>gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo
sapiens]
Length = 1150
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/75 (29%), Positives = 46/75 (61%), Gaps = 4/75 (5%)
Query: 579 QQEINSENLSAKELKKML----SKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEE 634
++E+ S LS+K LK L +KQ + +++ + ++E + +E+E + + +K D++EEE
Sbjct: 645 RKELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEE 704
Query: 635 ASGLKEELIPEKLER 649
+EE+ ++ ER
Sbjct: 705 ERKRQEEIERQRRER 719
Score = 32.7 bits (73), Expect = 1.5
Identities = 23/99 (23%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 562 IEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLS--------KQRRAQKKAKLEEERK 613
+ IY L P + K+++ S+ K+ K+ K+R++ +E+R
Sbjct: 784 VRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEPKPKRRKSGDDKDKKEDRD 843
Query: 614 HAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVEN 652
++E ++K+ K DE EE+ + ++E P + E E+
Sbjct: 844 ERKKEDKRKDDSKDDDETEEDNN--QDEYDPMEAEEAED 880
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/85 (29%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRA-QKKAKLEEERKHAERERQQKNQKKKRDEEEEE 634
E K E A+E ++M +++RA +++ +++EE K A ERQ+ +++KR EE +
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 635 ASGLKEELIPEKLERVENPLEEAVK 659
+E+ E+ +R EE K
Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAK 382
Score = 40.4 bits (93), Expect = 0.007
Identities = 23/83 (27%), Positives = 49/83 (59%), Gaps = 2/83 (2%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRA-QKKAKLEEERKHAERERQQ-KNQKKKRDEEEE 633
E +++ E +A+E +++ +++RA +++ +++EE K A ERQ+ K ++K+ EE +
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 371
Query: 634 EASGLKEELIPEKLERVENPLEE 656
A +EE + ++ LEE
Sbjct: 372 RARAEEEEKAKVEEQKRNKQLEE 394
Score = 36.6 bits (83), Expect = 0.10
Identities = 21/80 (26%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRR--AQKKAKLEEERKHA--ERERQQKNQKKKRDEE 631
+ ++ E L A+E +++ ++Q + A ++A++E E K A ERER++ ++++ EE
Sbjct: 261 DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
Query: 632 EEEASGLKEELIPEKLERVE 651
E+ A+ ++ + E+ E
Sbjct: 321 EKRAAEERQRIKEEEKRAAE 340
Score = 36.2 bits (82), Expect = 0.13
Identities = 33/133 (24%), Positives = 65/133 (48%), Gaps = 8/133 (6%)
Query: 536 RAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYD---NPLTNESK----QQEINSENLS 588
RA + R+++ +R A + AR+ E K+ + N E K + +I E +
Sbjct: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
Query: 589 AKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLE 648
K K +++++ + K + +K E E+ K Q K+ +E++ + KEE+ EK++
Sbjct: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGE-EKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 469
Query: 649 RVENPLEEAVKFL 661
+ + P EE F+
Sbjct: 470 KDKEPKEEVKSFM 482
Score = 35.8 bits (81), Expect = 0.18
Identities = 19/77 (24%), Positives = 43/77 (55%), Gaps = 2/77 (2%)
Query: 585 ENLSAKELKKMLSKQRR--AQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEEL 642
E + A++ KK+ ++ R A++KA +E + ER++ +++KR EE + +E+
Sbjct: 278 ERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKR 337
Query: 643 IPEKLERVENPLEEAVK 659
E+ +R++ + A +
Sbjct: 338 AAEERQRIKEEEKRAAE 354
Score = 35.8 bits (81), Expect = 0.18
Identities = 26/71 (36%), Positives = 39/71 (54%), Gaps = 9/71 (12%)
Query: 589 AKELKKMLSKQRRA-----QKKAKLEEERKHAERERQQKNQK---KKRDEEEEEASGLKE 640
++E +K+ KQ+ A + K K EE RK E E Q++ Q+ +K EEEE+ LKE
Sbjct: 548 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR-LKE 606
Query: 641 ELIPEKLERVE 651
E+ + E E
Sbjct: 607 EIERRRAEAAE 617
Score = 34.3 bits (77), Expect = 0.51
Identities = 21/87 (24%), Positives = 48/87 (55%), Gaps = 3/87 (3%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLE---EERKHAERERQQKNQKKKRDEEE 632
+ +++E S+ +S E + K+R ++A+LE ER AE++++ +++ + + EE
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE 299
Query: 633 EEASGLKEELIPEKLERVENPLEEAVK 659
+ A+ +E E+ ER+ + A +
Sbjct: 300 KAAAQERERREAEERERMREEEKRAAE 326
Score = 33.9 bits (76), Expect = 0.67
Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 11/122 (9%)
Query: 544 LEDILRRHAFYFKAARSAIEIYLKLYDNPLTNES------KQQEINSENLSAKELKKMLS 597
LE + RR K + A+E K +D +T+ S + Q +EN + ++ +K S
Sbjct: 97 LERLARREERRQKRLQEALERQ-KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSES 155
Query: 598 KQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEA 657
+Q R + + + + + + + + KK D+E+EE +EE P++ EN +E
Sbjct: 156 RQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE----EEEEKPKRGSIGENQVEVM 211
Query: 658 VK 659
V+
Sbjct: 212 VE 213
Score = 33.9 bits (76), Expect = 0.67
Identities = 21/86 (24%), Positives = 44/86 (51%), Gaps = 5/86 (5%)
Query: 573 LTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQK---NQKKKRD 629
+ E K+ + + +E + +QR +++ + EER+ A E ++K ++K+
Sbjct: 331 IKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
Query: 630 EEEEEASGLKEELIPEKLERVENPLE 655
+ EE+ ++E I K E+VE +E
Sbjct: 391 QLEEKKHAMQETKI--KGEKVEQKIE 414
Score = 30.0 bits (66), Expect = 9.6
Identities = 21/59 (35%), Positives = 32/59 (54%), Gaps = 7/59 (11%)
Query: 598 KQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEE 656
++RR ++ K EE R AER Q+N D++EEEA+ +E + ER+ EE
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRN-----DDDEEEAA--RERRRRARQERLRQKQEE 56
>gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo
sapiens]
Length = 1272
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/80 (26%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E K++ + + K K+ ++++ ++K K EEE K E E ++K+Q+++R ++EE+A
Sbjct: 54 EDKKKRLEDD----KRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQA 109
Query: 636 SGLKEELIPEKLERVENPLE 655
+EE +++ E ++
Sbjct: 110 KRQQEEEAAAQMKEKEESIQ 129
Score = 37.7 bits (86), Expect = 0.046
Identities = 65/282 (23%), Positives = 115/282 (40%), Gaps = 58/282 (20%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDE--- 630
T SK++ + L+AK K +SK +KK +++RK ++ER++K+++K + E
Sbjct: 30 TVSSKERPKDDIKLTAK---KEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEES 86
Query: 631 ---EEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGK 687
EEEE +EE ++ E+ + EE + K ++I H A+E + +
Sbjct: 87 KKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKE---ESIQLHQEAWERHHLR-- 141
Query: 688 FLLMLQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLE 747
K + N N P S+ N + D S + FVKK L+
Sbjct: 142 --------KELRSKNQNAP--------DSRPEENFFSRLD-----SSLKKNTAFVKK-LK 179
Query: 748 SFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQEKAIAIATRLDETIKDKDVKTLIKVSEA 807
+ E + SL H +G + ++ A A+A+ ++ +K DV + +
Sbjct: 180 TITE----QQRDSLSHDFNGLNLSKYI-------AEAVASIVEAKLKISDVNCAVHL--- 225
Query: 808 LLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPAVNEVDNPNV 849
CS ++ Y +LL A E PN+
Sbjct: 226 --------CSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNI 259
Score = 30.8 bits (68), Expect = 5.6
Identities = 24/96 (25%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 572 PLTNESKQQEINSENLSAKELKKMLSKQR-------RAQKK-AKLEEERKHAERERQQKN 623
P + E K N++ E + + SK+R A+K+ +K E++K + ++K
Sbjct: 8 PASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKK 67
Query: 624 QKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVK 659
+ K+R +++EE +EE ++ E + EE K
Sbjct: 68 EDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERK 103
>gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo
sapiens]
Length = 1272
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/80 (26%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 576 ESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEA 635
E K++ + + K K+ ++++ ++K K EEE K E E ++K+Q+++R ++EE+A
Sbjct: 54 EDKKKRLEDD----KRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQA 109
Query: 636 SGLKEELIPEKLERVENPLE 655
+EE +++ E ++
Sbjct: 110 KRQQEEEAAAQMKEKEESIQ 129
Score = 37.7 bits (86), Expect = 0.046
Identities = 65/282 (23%), Positives = 115/282 (40%), Gaps = 58/282 (20%)
Query: 574 TNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDE--- 630
T SK++ + L+AK K +SK +KK +++RK ++ER++K+++K + E
Sbjct: 30 TVSSKERPKDDIKLTAK---KEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEES 86
Query: 631 ---EEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGK 687
EEEE +EE ++ E+ + EE + K ++I H A+E + +
Sbjct: 87 KKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKE---ESIQLHQEAWERHHLR-- 141
Query: 688 FLLMLQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLE 747
K + N N P S+ N + D S + FVKK L+
Sbjct: 142 --------KELRSKNQNAP--------DSRPEENFFSRLD-----SSLKKNTAFVKK-LK 179
Query: 748 SFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQEKAIAIATRLDETIKDKDVKTLIKVSEA 807
+ E + SL H +G + ++ A A+A+ ++ +K DV + +
Sbjct: 180 TITE----QQRDSLSHDFNGLNLSKYI-------AEAVASIVEAKLKISDVNCAVHL--- 225
Query: 808 LLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPAVNEVDNPNV 849
CS ++ Y +LL A E PN+
Sbjct: 226 --------CSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNI 259
Score = 30.8 bits (68), Expect = 5.6
Identities = 24/96 (25%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 572 PLTNESKQQEINSENLSAKELKKMLSKQR-------RAQKK-AKLEEERKHAERERQQKN 623
P + E K N++ E + + SK+R A+K+ +K E++K + ++K
Sbjct: 8 PASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKK 67
Query: 624 QKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVK 659
+ K+R +++EE +EE ++ E + EE K
Sbjct: 68 EDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERK 103
>gi|157785548 PAS domain containing 1 [Homo sapiens]
Length = 773
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/96 (25%), Positives = 53/96 (55%), Gaps = 7/96 (7%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKN-------QKKKRDE 630
++Q + + +E + L +QR+ QK+ K++E++K E++ Q+K QKKK+ +
Sbjct: 485 QEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQ 544
Query: 631 EEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKN 666
E ++ G + PE+ ++ + E+ +K + + N
Sbjct: 545 ERKKWQGQMLQKEPEEEQQKQQLQEQPLKHNVIVGN 580
Score = 38.9 bits (89), Expect = 0.021
Identities = 30/109 (27%), Positives = 53/109 (48%), Gaps = 20/109 (18%)
Query: 578 KQQEINSENLSAKELKKMLSKQRRAQKKAKLEE----ERKHAERERQQKNQK-------- 625
+QQ E L ++ + KQ++ Q+K KL+E E+K + +R+QK +K
Sbjct: 491 EQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQ 550
Query: 626 ----KKRDEEEEEASGLKEELIPEKL----ERVENPLEEAVKFLIPLKN 666
+K EEE++ L+E+ + + ERV+ L+ +PL N
Sbjct: 551 GQMLQKEPEEEQQKQQLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCN 599
>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo
sapiens]
Length = 504
Score = 42.4 bits (98), Expect = 0.002
Identities = 72/334 (21%), Positives = 134/334 (40%), Gaps = 40/334 (11%)
Query: 360 SPYENGEKEPPTTLLW---VQYFLAQHFDKLGQ--YSLALDYINAAIASTPTLIELFYMK 414
+P EN EKE + L+ +Q +Q + G Y+ A+ +++ + EL ++
Sbjct: 135 NPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELR 194
Query: 415 AKIYKHIGNLKEAAKWMDEAQSL--DTADRFINSKCAKYMLRANMIKEAE-EMCSKFTRE 471
A+ + G ++A + A L D + F Y L + + +E C K ++
Sbjct: 195 AECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQD 254
Query: 472 GTSAMENLNEMQCMWFQTECISAYQRLGRYGDALKKCHEV---ERHFFEITDDQFDFHTY 528
+ +++ + E R GRY DA K V E E T + +
Sbjct: 255 HKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICH 314
Query: 529 CMRKMTLRAYVDLLRL-EDILRRHAFYFKAARSAIEIYL--KLYDNPLTNESKQQEINSE 585
C K V+ +R+ ++L+ A + E YL ++YD + + QE N
Sbjct: 315 CFSKD--EKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNEN 372
Query: 586 NLSAKE--------LK--------KMLSKQRRAQKKAKLEEERKHA--------ERERQQ 621
+ +E LK K+L +R A+K+ ++ RK A + E ++
Sbjct: 373 DQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEK 432
Query: 622 KNQKKKRDEEEEEASGLKEELIPEKLERVENPLE 655
K +KK + L + + +K + E+PL+
Sbjct: 433 KKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLD 466
>gi|189083802 myosin VIIA isoform 2 [Homo sapiens]
Length = 2175
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/71 (35%), Positives = 44/71 (61%), Gaps = 3/71 (4%)
Query: 582 INSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEE 641
+ +E + E +K+ ++ + KKAK E ERKH ER Q + +R+ +E+EA+ K+E
Sbjct: 867 LEAEKMRLAEEEKL--RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEAARRKKE 924
Query: 642 LIPEKLERVEN 652
L+ E++ER +
Sbjct: 925 LL-EQMERARH 934
>gi|189083800 myosin VIIA isoform 3 [Homo sapiens]
Length = 1204
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/71 (35%), Positives = 44/71 (61%), Gaps = 3/71 (4%)
Query: 582 INSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEE 641
+ +E + E +K+ ++ + KKAK E ERKH ER Q + +R+ +E+EA+ K+E
Sbjct: 867 LEAEKMRLAEEEKL--RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEAARRKKE 924
Query: 642 LIPEKLERVEN 652
L+ E++ER +
Sbjct: 925 LL-EQMERARH 934
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,847,081
Number of Sequences: 37866
Number of extensions: 1299498
Number of successful extensions: 21562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 428
Number of HSP's successfully gapped in prelim test: 589
Number of HSP's that attempted gapping in prelim test: 10086
Number of HSP's gapped (non-prelim): 7271
length of query: 864
length of database: 18,247,518
effective HSP length: 111
effective length of query: 753
effective length of database: 14,044,392
effective search space: 10575427176
effective search space used: 10575427176
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.