Guide to the Human Genome
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Search of human proteins with 33188431

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
sapiens]
         (1347 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap...  2760   0.0  
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap...  2544   0.0  
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ...  2344   0.0  
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap...  2022   0.0  
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]        697   0.0  
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       55   3e-07
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       55   3e-07
gi|118402596 cell division cycle protein 23 [Homo sapiens]             54   8e-07
gi|161016767 mucin 21 [Homo sapiens]                                   52   3e-06
gi|224809432 transmembrane and tetratricopeptide repeat containi...    51   7e-06
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 51   9e-06
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        50   1e-05
gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo ...    50   1e-05
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     49   4e-05
gi|118766328 transmembrane and tetratricopeptide repeat containi...    47   1e-04
gi|118766330 transmembrane and tetratricopeptide repeat containi...    47   1e-04
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]           47   1e-04
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         47   2e-04
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    45   6e-04
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    45   6e-04
gi|89026265 PREDICTED: mucin 12 [Homo sapiens]                         42   0.004
gi|239758148 PREDICTED: similar to mucin 11 [Homo sapiens]             41   0.007
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa...    41   0.007
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa...    41   0.007
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa...    41   0.007
gi|151301154 mucin 6, gastric [Homo sapiens]                           41   0.007
gi|60097902 filaggrin [Homo sapiens]                                   41   0.009
gi|22749211 transmembrane and tetratricopeptide repeat containin...    40   0.012
gi|239754668 PREDICTED: mucin 12 [Homo sapiens]                        40   0.015
gi|83415184 transmembrane and tetratricopeptide repeat containin...    40   0.020

>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sapiens]
          Length = 1347

 Score = 2760 bits (7155), Expect = 0.0
 Identities = 1347/1347 (100%), Positives = 1347/1347 (100%)

Query: 1    MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH 60
            MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH
Sbjct: 1    MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH 60

Query: 61   EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ 120
            EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ
Sbjct: 61   EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ 120

Query: 121  ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY 180
            ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY
Sbjct: 121  ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY 180

Query: 181  KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA 240
            KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA
Sbjct: 181  KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA 240

Query: 241  TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300
            TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA
Sbjct: 241  TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300

Query: 301  FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360
            FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE
Sbjct: 301  FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360

Query: 361  SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL 420
            SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL
Sbjct: 361  SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL 420

Query: 421  TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS 480
            TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS
Sbjct: 421  TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS 480

Query: 481  SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI 540
            SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI
Sbjct: 481  SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI 540

Query: 541  LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL 600
            LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL
Sbjct: 541  LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL 600

Query: 601  SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG 660
            SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG
Sbjct: 601  SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG 660

Query: 661  IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL 720
            IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL
Sbjct: 661  IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL 720

Query: 721  IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST 780
            IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST
Sbjct: 721  IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST 780

Query: 781  EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840
            EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS
Sbjct: 781  EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840

Query: 841  TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF 900
            TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF
Sbjct: 841  TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF 900

Query: 901  PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD 960
            PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD
Sbjct: 901  PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD 960

Query: 961  PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGR 1020
            PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGR
Sbjct: 961  PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGR 1020

Query: 1021 RRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQ 1080
            RRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQ
Sbjct: 1021 RRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQ 1080

Query: 1081 LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSW 1140
            LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSW
Sbjct: 1081 LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSW 1140

Query: 1141 WPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV 1200
            WPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV
Sbjct: 1141 WPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV 1200

Query: 1201 ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAA 1260
            ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAA
Sbjct: 1201 ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAA 1260

Query: 1261 GKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFV 1320
            GKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFV
Sbjct: 1261 GKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFV 1320

Query: 1321 VLEQYKMEDLIQVYDQFTLALSLSSSS 1347
            VLEQYKMEDLIQVYDQFTLALSLSSSS
Sbjct: 1321 VLEQYKMEDLIQVYDQFTLALSLSSSS 1347


>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sapiens]
          Length = 1240

 Score = 2545 bits (6595), Expect = 0.0
 Identities = 1240/1240 (100%), Positives = 1240/1240 (100%)

Query: 1    MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH 60
            MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH
Sbjct: 1    MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH 60

Query: 61   EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ 120
            EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ
Sbjct: 61   EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ 120

Query: 121  ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY 180
            ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY
Sbjct: 121  ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY 180

Query: 181  KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA 240
            KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA
Sbjct: 181  KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA 240

Query: 241  TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300
            TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA
Sbjct: 241  TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300

Query: 301  FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360
            FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE
Sbjct: 301  FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360

Query: 361  SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL 420
            SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL
Sbjct: 361  SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL 420

Query: 421  TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS 480
            TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS
Sbjct: 421  TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS 480

Query: 481  SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI 540
            SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI
Sbjct: 481  SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI 540

Query: 541  LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL 600
            LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL
Sbjct: 541  LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL 600

Query: 601  SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG 660
            SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG
Sbjct: 601  SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG 660

Query: 661  IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL 720
            IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL
Sbjct: 661  IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL 720

Query: 721  IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST 780
            IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST
Sbjct: 721  IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST 780

Query: 781  EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840
            EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS
Sbjct: 781  EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840

Query: 841  TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF 900
            TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF
Sbjct: 841  TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF 900

Query: 901  PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD 960
            PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD
Sbjct: 901  PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD 960

Query: 961  PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGR 1020
            PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGR
Sbjct: 961  PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGR 1020

Query: 1021 RRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQ 1080
            RRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQ
Sbjct: 1021 RRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQ 1080

Query: 1081 LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSW 1140
            LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSW
Sbjct: 1081 LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSW 1140

Query: 1141 WPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV 1200
            WPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV
Sbjct: 1141 WPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV 1200

Query: 1201 ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIK 1240
            ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIK
Sbjct: 1201 ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIK 1240


>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
            chromosome [Homo sapiens]
          Length = 1401

 Score = 2344 bits (6075), Expect = 0.0
 Identities = 1166/1400 (83%), Positives = 1232/1400 (88%), Gaps = 53/1400 (3%)

Query: 1    MKSCAVSLTTAAVA---FGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFV 57
            MKSC VSL TAA A   FGDE KKMA GKAS ESEE S SLT EEREALGG+DSRLFGFV
Sbjct: 1    MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFV 60

Query: 58   RLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYY 117
            R HEDGARTK LLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDY KALSAYQRYY
Sbjct: 61   RFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYY 120

Query: 118  SLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVN 177
            SLQ+DYWKNAAFLYGLGLVYF+YNAF WAIKAFQ+VLYVDPSFCRAKEIHLRLGLMFKVN
Sbjct: 121  SLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN 180

Query: 178  TDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQ 237
            TDY+SSLKHFQLAL+DCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENL AQ
Sbjct: 181  TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQ 240

Query: 238  VKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKV 297
            VKATVLQQLGWMHH +DL+GDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKV
Sbjct: 241  VKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKV 300

Query: 298  QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 357
            QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT
Sbjct: 301  QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 360

Query: 358  LYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQ---------------------- 395
            LYESCNQPQDAIKCYLNA RSK CSNTS LAARIK+LQ                      
Sbjct: 361  LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIE 420

Query: 396  -----------------------NGSDNWNGGQSLSHHPVQQ-VYSLCLTPQKLQHLEQL 431
                                   N SDNW+GG ++SH PVQQ  +S CLTPQKLQHLEQL
Sbjct: 421  EAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQHLEQL 480

Query: 432  RANRDNLNPAQKHQLEQLESQFVLMQQ--MRHKEVAQVRTTGIHNGAITDSSLPTNSVSN 489
            RANR+NLNPAQK  LEQLESQFVLMQQ  MR   VAQVR+TGI NG   DSSLPTNSVS 
Sbjct: 481  RANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNSVSG 540

Query: 490  RQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTILLGSNCIAG 549
            +QP  ALTRV SVSQPGVRPAC  + L++G FSAG +PC TS+ LGSTDTIL+G+N I G
Sbjct: 541  QQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITG 600

Query: 550  SESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPL 609
            S SNGNVPYLQ+N  TLPHN T+L SS EEPW+ QLSNS QGLHK QSS  +GPN E+PL
Sbjct: 601  SGSNGNVPYLQRNALTLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPL 660

Query: 610  FSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKP 669
             STG +Q+ QA  +GI+  N H TLPSNSV QG A +HLS HTATSGGQQGI  TKESKP
Sbjct: 661  SSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKP 720

Query: 670  SKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDS--PNLLIADNPQL 727
            S N   VPETSRHTG+T N  A V+GL NHVHQ+ ADAV SP+HGDS  P LL +DNPQL
Sbjct: 721  SGNILTVPETSRHTGETPNSTASVEGLPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQL 780

Query: 728  SALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINS 787
            SALL+GKAN NVGTGTCDKVNNIHPAVHTKTD+SVASSPSSAISTATPSPKSTEQ + NS
Sbjct: 781  SALLMGKANNNVGTGTCDKVNNIHPAVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNS 840

Query: 788  VTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSSTEVLKAC 847
            VTSLNSPHSGLHT+NGEG+ +SQS  K DL L +H+ + QI+PSMSVSI PSS EVLKAC
Sbjct: 841  VTSLNSPHSGLHTINGEGMEESQSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKAC 900

Query: 848  RNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFC 907
            RN GKNGLSNS ILLDKCPPPRPP+SPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFC
Sbjct: 901  RNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFC 960

Query: 908  TNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKI 967
            TNP NPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKI
Sbjct: 961  TNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKI 1020

Query: 968  WRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFK 1027
            W CESNRSHTTIAKYAQYQASSFQESLREENEKR+ HKDHSD+ESTSS+NSGRRRKGPFK
Sbjct: 1021 WHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFK 1080

Query: 1028 TIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPG 1087
            TIKFGTNIDLSD+KKWKLQLHELTKLPAF RVVSAGNLL+HVGHTILGMNTVQLYMKVPG
Sbjct: 1081 TIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPG 1140

Query: 1088 SRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDL 1147
            SRTPGHQENNNFCSVNINIGPGDCEWFVVPE YWGVLNDFCEKNNLNFLM SWWPNLEDL
Sbjct: 1141 SRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDL 1200

Query: 1148 YEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNK 1207
            YEANVPVYRFIQRPGDLVWINAGTVHWVQA+GWCNNIAWNVGPLTACQYKLAVERYEWNK
Sbjct: 1201 YEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNK 1260

Query: 1208 LKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWH 1267
            L+SVKS VPMVHLSWNMARNIKVSDPKLFEMIKYCLL+ LKQ QTLREAL+AAGKE+IWH
Sbjct: 1261 LQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWH 1320

Query: 1268 GRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKM 1327
            GRT +EPAHYCSICEVEVF+LLFVTNESN++KTYIVHC DCARKTS +LENFVVLEQYKM
Sbjct: 1321 GRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKM 1380

Query: 1328 EDLIQVYDQFTLALSLSSSS 1347
            EDL+QVYDQFTLA  L S+S
Sbjct: 1381 EDLMQVYDQFTLAPPLPSAS 1400


>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
           sapiens]
          Length = 1079

 Score = 2022 bits (5239), Expect = 0.0
 Identities = 995/995 (100%), Positives = 995/995 (100%)

Query: 1   MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH 60
           MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH
Sbjct: 1   MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLH 60

Query: 61  EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ 120
           EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ
Sbjct: 61  EDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQ 120

Query: 121 ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY 180
           ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY
Sbjct: 121 ADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDY 180

Query: 181 KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA 240
           KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA
Sbjct: 181 KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKA 240

Query: 241 TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300
           TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA
Sbjct: 241 TVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300

Query: 301 FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360
           FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE
Sbjct: 301 FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 360

Query: 361 SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL 420
           SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL
Sbjct: 361 SCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCL 420

Query: 421 TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS 480
           TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS
Sbjct: 421 TPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDS 480

Query: 481 SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI 540
           SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI
Sbjct: 481 SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTI 540

Query: 541 LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL 600
           LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL
Sbjct: 541 LLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCL 600

Query: 601 SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG 660
           SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG
Sbjct: 601 SGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQG 660

Query: 661 IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL 720
           IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL
Sbjct: 661 IMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLL 720

Query: 721 IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST 780
           IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST
Sbjct: 721 IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKST 780

Query: 781 EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840
           EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS
Sbjct: 781 EQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840

Query: 841 TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF 900
           TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF
Sbjct: 841 TEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFF 900

Query: 901 PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD 960
           PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD
Sbjct: 901 PPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWD 960

Query: 961 PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLR 995
           PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLR
Sbjct: 961 PTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLR 995


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score =  697 bits (1800), Expect = 0.0
 Identities = 342/589 (58%), Positives = 427/589 (72%), Gaps = 9/589 (1%)

Query: 752  PAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNS-PHSGLHTVNGEGLGKSQ 810
            PA   +     AS P        P P    +  +  + SL+  P   L       L K +
Sbjct: 1056 PAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPPKELKI----RLIKVE 1111

Query: 811  SSTKVDLPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRP 870
            S  K     +        +  +++S C  + +V++A RN    G      L       +P
Sbjct: 1112 SGDKETFIASEVEERRLRMADLTISHC--AADVVRASRNAKVKGKFRESYL-SPAQSVKP 1168

Query: 871  PTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGL 930
              +    LP++KLNPPTPSIYLE+KRDAF P L QFCT+P+NP+TVIRGLAG+L+L+LGL
Sbjct: 1169 KINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGL 1228

Query: 931  FSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSF 990
            FSTKTLVEA+ EH VEVRTQ+ QP+DENWD TGT++IW CES+RSHTTIAKYAQYQASSF
Sbjct: 1229 FSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSF 1288

Query: 991  QESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHEL 1050
            QESL+EE E   +  +  D+ + +  +S    K     IKFGTNIDLSD K+WK QL EL
Sbjct: 1289 QESLQEEKESEDEESEEPDSTTGTPPSSAPDPKN-HHIIKFGTNIDLSDAKRWKPQLQEL 1347

Query: 1051 TKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD 1110
             KLPAF RV S GN+L+HVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD
Sbjct: 1348 LKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD 1407

Query: 1111 CEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAG 1170
            CEWF V E YW  ++ FC+++ +++L  SWWP L+DLY +N+PVYRF+QRPGDLVWINAG
Sbjct: 1408 CEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAG 1467

Query: 1171 TVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSPVPMVHLSWNMARNIKV 1230
            TVHWVQA GWCNNIAWNVGPLTA QY+LA+ERYEWN++K+VKS VPM+H+SWN+AR +K+
Sbjct: 1468 TVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKI 1527

Query: 1231 SDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLF 1290
            SDP LF+MIK+CLL+ +K  Q  RE+LV AGK++ + GR  DEPA+YC+ C+VEVFN+LF
Sbjct: 1528 SDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILF 1587

Query: 1291 VTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTL 1339
            VT+E+ ++ TY+VHC  CAR+ S  L+  VVLEQY+ E+L Q YD FTL
Sbjct: 1588 VTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTL 1636



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 22/196 (11%)

Query: 249 MHHNMDLVGDKATKESYAIQYLQ-----KSLEADPNSGQSWYFLGRCYSSIGKVQ-DAFI 302
           MH  +D  G +A +E++A+  L       S    P    +W   GRC +SIG+    A +
Sbjct: 1   MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPL 60

Query: 303 SYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESC 362
                      S   +       +  +  +++L   + A+  +      W  LG LYES 
Sbjct: 61  PPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESE 120

Query: 363 NQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHH------PVQQVY 416
           +  ++A +CY +A R     + + L  RI  LQ  +  WN       H      P++QV+
Sbjct: 121 HDSEEATRCYHSALRYG--GSFAELGPRIGRLQQ-AQLWNFHTGSCQHRAKVLPPLEQVW 177

Query: 417 SLCLTPQKLQHLEQLR 432
           +L        HLE  R
Sbjct: 178 NLL-------HLEHKR 186



 Score = 30.8 bits (68), Expect = 9.2
 Identities = 16/40 (40%), Positives = 20/40 (50%), Gaps = 4/40 (10%)

Query: 866 PPPRPPTSPYPPLPKDKLNPP----TPSIYLENKRDAFFP 901
           PPP PP  P PPLP    +PP     P ++     DA+ P
Sbjct: 253 PPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGP 292


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 71/336 (21%), Positives = 137/336 (40%), Gaps = 47/336 (13%)

Query: 73  AVRCYESLILKAEGKVESDFFC---QLGHFNLLLEDYSKALSAYQRYYSLQADY---WKN 126
           AV+ Y S +     +   D +C    LG+    L    +A + Y +    Q ++   W N
Sbjct: 132 AVQAYVSAL-----QYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186

Query: 127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKH 186
                 LG V+        AI  F+  + +DP+F  A   ++ LG + K    +  ++  
Sbjct: 187 ------LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA---YINLGNVLKEARIFDRAVAA 237

Query: 187 FQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--------NLPAQV 238
           +  AL      + ++A +  ++A +Y  Q     A + Y + ++ +        NL   +
Sbjct: 238 YLRAL----SLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANAL 293

Query: 239 KA-----------TVLQQLGWMH----HNMDLVGDKATKESYAIQYLQKSLEADPNSGQS 283
           K                +L   H    +N+  +  +      A++  +K+LE  P    +
Sbjct: 294 KEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAA 353

Query: 284 WYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQ 343
              L       GK+Q+A + Y+++I  S   AD + ++G   ++      ALQ Y  A+Q
Sbjct: 354 HSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ 413

Query: 344 LDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSK 379
           ++   A A  +L ++++      +AI  Y  A + K
Sbjct: 414 INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLK 449



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 25/107 (23%), Positives = 51/107 (47%)

Query: 273 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 332
           +++ +P   +++  LG  Y   G++Q+A   YR ++       D + ++           
Sbjct: 71  AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130

Query: 333 DALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSK 379
            A+QAY+ A+Q +        DLG L ++  + ++A  CYL A  ++
Sbjct: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQ 177



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 55/258 (21%), Positives = 101/258 (39%), Gaps = 41/258 (15%)

Query: 91  DFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYG-LGLVYFYYNAFHWAIKA 149
           D +  LG+       + +A++AY R  SL      N A ++G L  VY+       AI  
Sbjct: 216 DAYINLGNVLKEARIFDRAVAAYLRALSLSP----NHAVVHGNLACVYYEQGLIDLAIDT 271

Query: 150 FQDVLYVDPSF----CRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSN-AEI 204
           ++  + + P F    C         G + +    Y ++L+     L   +  +L+N A I
Sbjct: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALR-----LCPTHADSLNNLANI 326

Query: 205 QFHIAHLYETQRKYHSAKEAYEQLLQTE-NLPAQVKATVLQQLG-----WMHHNMDLVGD 258
           +    ++ E  R Y  A E + +      NL     A+VLQQ G      MH+   +   
Sbjct: 327 KREQGNIEEAVRLYRKALEVFPEFAAAHSNL-----ASVLQQQGKLQEALMHYKEAIRIS 381

Query: 259 KATKESY---------------AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFIS 303
               ++Y               A+Q   ++++ +P    +   L   +   G + +A  S
Sbjct: 382 PTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIAS 441

Query: 304 YRQSIDKSEASADTWCSI 321
           YR ++       D +C++
Sbjct: 442 YRTALKLKPDFPDAYCNL 459


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 71/336 (21%), Positives = 137/336 (40%), Gaps = 47/336 (13%)

Query: 73  AVRCYESLILKAEGKVESDFFC---QLGHFNLLLEDYSKALSAYQRYYSLQADY---WKN 126
           AV+ Y S +     +   D +C    LG+    L    +A + Y +    Q ++   W N
Sbjct: 142 AVQAYVSAL-----QYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 196

Query: 127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKH 186
                 LG V+        AI  F+  + +DP+F  A   ++ LG + K    +  ++  
Sbjct: 197 ------LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA---YINLGNVLKEARIFDRAVAA 247

Query: 187 FQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--------NLPAQV 238
           +  AL      + ++A +  ++A +Y  Q     A + Y + ++ +        NL   +
Sbjct: 248 YLRAL----SLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANAL 303

Query: 239 KA-----------TVLQQLGWMH----HNMDLVGDKATKESYAIQYLQKSLEADPNSGQS 283
           K                +L   H    +N+  +  +      A++  +K+LE  P    +
Sbjct: 304 KEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAA 363

Query: 284 WYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQ 343
              L       GK+Q+A + Y+++I  S   AD + ++G   ++      ALQ Y  A+Q
Sbjct: 364 HSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ 423

Query: 344 LDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSK 379
           ++   A A  +L ++++      +AI  Y  A + K
Sbjct: 424 INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLK 459



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 25/107 (23%), Positives = 51/107 (47%)

Query: 273 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 332
           +++ +P   +++  LG  Y   G++Q+A   YR ++       D + ++           
Sbjct: 81  AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 140

Query: 333 DALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSK 379
            A+QAY+ A+Q +        DLG L ++  + ++A  CYL A  ++
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQ 187



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 55/258 (21%), Positives = 101/258 (39%), Gaps = 41/258 (15%)

Query: 91  DFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYG-LGLVYFYYNAFHWAIKA 149
           D +  LG+       + +A++AY R  SL      N A ++G L  VY+       AI  
Sbjct: 226 DAYINLGNVLKEARIFDRAVAAYLRALSLSP----NHAVVHGNLACVYYEQGLIDLAIDT 281

Query: 150 FQDVLYVDPSF----CRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSN-AEI 204
           ++  + + P F    C         G + +    Y ++L+     L   +  +L+N A I
Sbjct: 282 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALR-----LCPTHADSLNNLANI 336

Query: 205 QFHIAHLYETQRKYHSAKEAYEQLLQTE-NLPAQVKATVLQQLG-----WMHHNMDLVGD 258
           +    ++ E  R Y  A E + +      NL     A+VLQQ G      MH+   +   
Sbjct: 337 KREQGNIEEAVRLYRKALEVFPEFAAAHSNL-----ASVLQQQGKLQEALMHYKEAIRIS 391

Query: 259 KATKESY---------------AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFIS 303
               ++Y               A+Q   ++++ +P    +   L   +   G + +A  S
Sbjct: 392 PTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIAS 451

Query: 304 YRQSIDKSEASADTWCSI 321
           YR ++       D +C++
Sbjct: 452 YRTALKLKPDFPDAYCNL 469


>gi|118402596 cell division cycle protein 23 [Homo sapiens]
          Length = 597

 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 32/110 (29%), Positives = 49/110 (44%)

Query: 266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 325
           A  Y Q++L+ +P    +W  +G  Y  +     A  +YR +I+ ++     W  +G  Y
Sbjct: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409

Query: 326 QQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
           +    P   L  Y  A QL    +   + LG  YE  NQ  +A KCY  A
Sbjct: 410 EILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 58/285 (20%), Positives = 117/285 (41%), Gaps = 26/285 (9%)

Query: 91  DFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAF 150
           +FF  L H    L+   +AL  YQ    +   + K++  +  + + Y        A+  F
Sbjct: 231 EFF--LAHIYTELQLIEEALQKYQNL--IDVGFSKSSYIVSQIAVAYHNIRDIDKALSIF 286

Query: 151 QDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFH--I 208
            ++   DP   R + +     L+      Y  S+K  +L+ +  N C +    ++    I
Sbjct: 287 NELRKQDPY--RIENMDTFSNLL------YVRSMKS-ELSYLAHNLCEIDKYRVETCCVI 337

Query: 209 AHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQ 268
            + Y  + ++  A   +++ L+    P  + A  L      H  M++    A     AIQ
Sbjct: 338 GNYYSLRSQHEKAALYFQRALKLN--PRYLGAWTLMG----HEYMEMKNTSA-----AIQ 386

Query: 269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQ 328
             + ++E +    ++WY LG+ Y  +         YR++       +    ++G  Y++ 
Sbjct: 387 AYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKL 446

Query: 329 NQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYL 373
           NQ ++A + Y  A  +      A + L  L+E   + + A +CY+
Sbjct: 447 NQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYI 491



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 38/198 (19%), Positives = 79/198 (39%), Gaps = 30/198 (15%)

Query: 205 QFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHN-------MDLVG 257
           +F +AH+Y   +    A + Y+ L+   ++     + ++ Q+   +HN       + +  
Sbjct: 231 EFFLAHIYTELQLIEEALQKYQNLI---DVGFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287

Query: 258 DKATKESYAIQ-------------------YLQKSL-EADPNSGQSWYFLGRCYSSIGKV 297
           +   ++ Y I+                   YL  +L E D    ++   +G  YS   + 
Sbjct: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQH 347

Query: 298 QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 357
           + A + +++++  +      W  +G  Y +      A+QAY  A++++     AW  LG 
Sbjct: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407

Query: 358 LYESCNQPQDAIKCYLNA 375
            YE    P   +  Y  A
Sbjct: 408 TYEILKMPFYCLYYYRRA 425



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 38/211 (18%), Positives = 79/211 (37%), Gaps = 24/211 (11%)

Query: 170 LGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLL 229
           +G  + + + ++ +  +FQ AL   NP  L    +   + H Y   +   +A +AY   +
Sbjct: 337 IGNYYSLRSQHEKAALYFQRAL-KLNPRYLGAWTL---MGHEYMEMKNTSAAIQAYRHAI 392

Query: 230 QTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
           +      +          W  + +    +      Y + Y +++ +  PN  +    LG 
Sbjct: 393 EVNKRDYRA---------W--YGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441

Query: 290 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYI--------CA 341
           CY  + ++ +A   Y ++    +        +  L++Q  +   A Q YI        C 
Sbjct: 442 CYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCG 501

Query: 342 VQLDH-GHAAAWMDLGTLYESCNQPQDAIKC 371
             ++H   + A+  L   Y  C    +A  C
Sbjct: 502 EIVEHLEESTAFRYLAQYYFKCKLWDEASTC 532


>gi|161016767 mucin 21 [Homo sapiens]
          Length = 566

 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 88/458 (19%), Positives = 156/458 (34%), Gaps = 22/458 (4%)

Query: 372 YLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVY----SLCLTPQKLQH 427
           +L AA +   ++TS            S   N G S++   V        S+      +  
Sbjct: 17  HLEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVT 76

Query: 428 LEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDSS---LPT 484
             +       ++ A   +   + S   +         +   +T  ++ + T SS     T
Sbjct: 77  NSEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTATNSESSTPSSGASTAT 136

Query: 485 NSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTILLGS 544
           NS S+    GA T  +S S      A       S   S+G      S+    +      +
Sbjct: 137 NSDSSTTSSGASTATNSDSSTTSSEASTATNSESSTTSSGASTATNSESSTVSSRASTAT 196

Query: 545 NCIAGSESNGNVPYLQQNTHTLPHNH---TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLS 601
           N  + + S+G        + T  +     T+  SST        +NS      S +   +
Sbjct: 197 NSESSTTSSGASTATNSESRTTSNGAGTATNSESSTTSSGASTATNSESSTPSSGAG--T 254

Query: 602 GPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGI 661
             N E    S+G+     + S+ +      +T   +S P   A++  +  ++T+      
Sbjct: 255 ATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANTATNSESSTTSSGANT 314

Query: 662 MFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLI 721
               +S  + + +     S  +  +S         S+      + A +S +   S     
Sbjct: 315 ATNSDSSTTSSGASTATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTST 374

Query: 722 ADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTE 781
           A N + S +  G       T T  + +       T T +S +S+ SS  STAT S  ST 
Sbjct: 375 ATNSESSTVSSG-----ASTATTSESSTTSSGASTAT-NSESSTVSSGASTATNSESSTT 428

Query: 782 QRSINSVT----SLNSPHSGLHTVNGEGLGKSQSSTKV 815
               N+ T    S+ S  SG   + G       +ST V
Sbjct: 429 SSGANTATNSGSSVTSAGSGTAALTGMHTTSHSASTAV 466



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 67/341 (19%), Positives = 121/341 (35%), Gaps = 23/341 (6%)

Query: 515 LLSSGAFSAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLN 574
           ++SSGA +A     G+S       T  +  + +    SNG         HT     + ++
Sbjct: 37  VISSGASTA--TNSGSSVTSSGVSTATISGSSVT---SNGVSIVTNSEFHT---TSSGIS 88

Query: 575 SSTEEPWRKQLSNSAQGLHKSQSSCLSGP----NEEQPLFSTGSAQYHQATSTGIKKANE 630
           ++T   +    S  +   +   S+  SG     N E    S+G++    + S+       
Sbjct: 89  TATNSEFSTVSSGISIATNSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGAS 148

Query: 631 HLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGC 690
             T   +S    +A +  +  ++T+          ES    +R+     S  +  +S   
Sbjct: 149 TATNSDSSTTSSEASTATNSESSTTSSGASTATNSESSTVSSRASTATNSESSTTSSGAS 208

Query: 691 ADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKA----------NGNVG 740
                 S         A +S +   S     A N + S    G            +   G
Sbjct: 209 TATNSESRTTSNGAGTATNSESSTTSSGASTATNSESSTPSSGAGTATNSESSTTSSGAG 268

Query: 741 TGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHT 800
           T T  + + +   + T T+ S +S+PSS  +TAT S  ST     N+ T+ +S  +    
Sbjct: 269 TATNSESSTVSSGISTVTN-SESSTPSSGANTATNSESSTTSSGANTATNSDSSTTSSGA 327

Query: 801 VNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSST 841
                   S +S+       S  ST+    S + +   S+T
Sbjct: 328 STATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTT 368



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 91/410 (22%), Positives = 148/410 (36%), Gaps = 37/410 (9%)

Query: 465 AQVRTTGIHNGAITDSSLPTNSVS---NRQPHGALTRVSSVSQPGVRPACVEKLLSSGAF 521
           + V ++G+    I+ SS+ +N VS   N + H   + +S+ +            +SSG  
Sbjct: 50  SSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEF------STVSSGIS 103

Query: 522 SAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPW 581
            A      T+    ST T    S   +G+ +  N       T +     T+ +SST    
Sbjct: 104 IATNSESSTTSSGASTATNSESSTPSSGASTATNSD--SSTTSSGASTATNSDSSTTSSE 161

Query: 582 RKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQ 641
               +NS      S +S  +  +E   + S  S   +  +ST    A+      S +   
Sbjct: 162 ASTATNSESSTTSSGASTATN-SESSTVSSRASTATNSESSTTSSGASTATNSESRTTSN 220

Query: 642 GDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVH 701
           G   +  S  + TS G      ++ S PS        +   T  +  G A     S+ V 
Sbjct: 221 GAGTATNSESSTTSSGASTATNSESSTPSSGAGTATNSESSTTSSGAGTA-TNSESSTVS 279

Query: 702 QLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHS 761
             I+   +S +   S     A N + S    G    N  T +            T +  S
Sbjct: 280 SGISTVTNSESSTPSSGANTATNSESSTTSSG---ANTATNSDSST--------TSSGAS 328

Query: 762 VASSP-----SSAISTATPSPKSTEQRSINSVTSLNS--PHSGLHTVNGE-----GLGKS 809
            A++      SS  STAT S  ST     ++ T+  S    SG  T           G S
Sbjct: 329 TATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTATNSESSTVSSGAS 388

Query: 810 QSSTKVDLPLASHRSTSQILPSMSVSI-CPSSTEVLKACRNPGKNGLSNS 858
            ++T      +S  ST+    S +VS    ++T    +  + G N  +NS
Sbjct: 389 TATTSESSTTSSGASTATNSESSTVSSGASTATNSESSTTSSGANTATNS 438


>gi|224809432 transmembrane and tetratricopeptide repeat containing
           3 [Homo sapiens]
          Length = 914

 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)

Query: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233
           F  N D++S    F  AL        +NA++  ++ H  E ++ +  A + + Q    + 
Sbjct: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476

Query: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281
            P  + A +   +G  + N++      TKE+     + KSL               PN  
Sbjct: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528

Query: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
             +  L     ++  ++++A   YRQ+I         + S G L  + N+P+ A +AY+ 
Sbjct: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588

Query: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
           A++LD  +A  W +L  ++    +P +A+K +  A
Sbjct: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 61/269 (22%), Positives = 116/269 (43%), Gaps = 26/269 (9%)

Query: 104 EDYSKALSAYQRYYSLQADYWKNAAFL---YGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
           EDY +A   +Q YY  QA  + +++F+   +GLG +Y Y      A + F+ VL   P+ 
Sbjct: 320 EDYDQA---FQYYY--QATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNN 374

Query: 161 CRAKEIHLRLGLMFKVNTDY--KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKY 218
               +I   LG ++  + D   +   K     + +  P    + E    +A + E Q   
Sbjct: 375 YETMKI---LGSLYAASEDQEKRDIAKGHLKKVTEQYP---DDVEAWIELAQILE-QTDI 427

Query: 219 HSAKEAY---EQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLE 275
             A  AY    ++LQ E + A V   +L  +G +H  +  +G+       ++   +   E
Sbjct: 428 QGALSAYGTATRILQ-EKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAE 486

Query: 276 ADPN-----SGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQ 330
            D +     S  + Y L R Y ++ +  +A   Y+  + +     D +  +G + + +  
Sbjct: 487 HDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGN 546

Query: 331 PMDALQAYICAVQLDHGHAAAWMDLGTLY 359
             +A   +  A+Q++  H  AW  +G L+
Sbjct: 547 FYEASDWFKEALQINQDHPDAWSLIGNLH 575



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 38/211 (18%), Positives = 94/211 (44%), Gaps = 10/211 (4%)

Query: 131 YGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLA 190
           Y L  +Y     FH A K ++++L   P++    + +LRLG M +   ++  +   F+ A
Sbjct: 501 YNLARLYEAMCEFHEAEKLYKNILREHPNYV---DCYLRLGAMARDKGNFYEASDWFKEA 557

Query: 191 LIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMH 250
           L         + +    I +L+  ++++   ++ +E++L+  +  +   + +     W+ 
Sbjct: 558 L----QINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQ 613

Query: 251 HNMDLVGDKATKESY---AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQS 307
                  D+  ++ +   A+   ++ L  D  +  +   +G   +  G  ++A   + Q 
Sbjct: 614 TLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQV 673

Query: 308 IDKSEASADTWCSIGVLYQQQNQPMDALQAY 338
            + +   +D W ++  +Y +Q Q + A+Q Y
Sbjct: 674 REATADISDVWLNLAHIYVEQKQYISAVQMY 704


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 75/325 (23%), Positives = 118/325 (36%), Gaps = 33/325 (10%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P  +T S    ++T++  +  + 
Sbjct: 951  TALPGSTTTPGLSERSTTFHSSPRSPATTLS------PASTTSSGVSEESTTSRSRPGST 1004

Query: 631  HLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGC 690
            H T    + P       LS H+ TS    G   T    P+   +  P     T  +S+G 
Sbjct: 1005 HTT----AFPDSTTTPGLSRHSTTSHSSPGSTDTT-LLPASTTTSGPSQESTTSHSSSGS 1059

Query: 691  ADVKGLSNHVHQLIADAVSSPNH---GDSPNLLIADNPQLSALLIGKANGNVGTG----T 743
             D          L     S+  H   G +   L  D+   S ++      +  TG    T
Sbjct: 1060 TDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTT 1119

Query: 744  CDKVNNIHPAV---------HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
                ++  P +         H  + H+  S PS+A  TA     +T  RS  S  + + P
Sbjct: 1120 LSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTA--TAPVEESTTYHRSPGSTPTTHFP 1177

Query: 795  HSGLHTVNGEGLGKSQSSTKVD--LPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGK 852
             S   + + E      SS       P ++H +TS    S +  I P STE+     +   
Sbjct: 1178 ASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTT 1237

Query: 853  NGLSNSCILLDKCPPPRPPTSPYPP 877
             GLS +         PR PT+   P
Sbjct: 1238 PGLSEASTTF--YSSPRSPTTTLSP 1260



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 75/325 (23%), Positives = 117/325 (36%), Gaps = 33/325 (10%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P  +T S    ++T++  +  + 
Sbjct: 2034 TALPGSTTTPGLSEKSTTFHSSPRSPATTLS------PASTTSSGVSEESTTSHSRPGST 2087

Query: 631  HLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGC 690
            H T    + P       LS H+ TS    G   T    P+   +  P     T  +S G 
Sbjct: 2088 HTT----AFPDSTTTPGLSRHSTTSHSSPGSTDTT-LLPASTTTSGPSQESTTSHSSPGS 2142

Query: 691  ADVKGLSNHVHQLIADAVSSPNH---GDSPNLLIADNPQLSALLIGKANGNVGTG----T 743
             D          L     S+  H   G +   L  D+   S ++      +  TG    T
Sbjct: 2143 TDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTT 2202

Query: 744  CDKVNNIHPAV---------HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
                ++  P +         H  + H+  S PS+A  TA     +T  RS  S  + + P
Sbjct: 2203 LSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTA--TAPVEESTTYHRSPGSTPTTHFP 2260

Query: 795  HSGLHTVNGEGLGKSQSSTKVD--LPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGK 852
             S   + + E      SS       P ++H +TS    S +  I P STE+     +   
Sbjct: 2261 ASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTT 2320

Query: 853  NGLSNSCILLDKCPPPRPPTSPYPP 877
             GLS +         PR PT+   P
Sbjct: 2321 PGLSEASTTF--YSSPRSPTTTLSP 2343



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 76/325 (23%), Positives = 118/325 (36%), Gaps = 33/325 (10%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P  +T S    ++T++  +  + 
Sbjct: 3591 TALPGSTTTPGLSEKSTTFHSSPRSPATTLS------PASTTSSGVSEESTTSHSRPGST 3644

Query: 631  HLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGC 690
            H T    + P       LS H+ TS    G   T     S   S   + S  T  +S+G 
Sbjct: 3645 HTT----AFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGSSQEST-TSHSSSGS 3699

Query: 691  ADVKGLSNHVHQLIADAVSSPNH---GDSPNLLIADNPQLSALLIGKANGNVGTG----T 743
             D          L     S+  H   G +   L  D+   S ++      +  TG    T
Sbjct: 3700 TDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTT 3759

Query: 744  CDKVNNIHPAV---------HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
                ++  P +         H  + H+  S PS+A  TA     +T  RS  S  + + P
Sbjct: 3760 LSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTA--TAPVEESTTYHRSPGSTPTTHFP 3817

Query: 795  HSGLHTVNGEGLGKSQSSTKVD--LPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGK 852
             S   + + E      SS       P ++H +TS    S +  I P STE+     +   
Sbjct: 3818 ASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTT 3877

Query: 853  NGLSNSCILLDKCPPPRPPTSPYPP 877
             GLS +         PR PT+   P
Sbjct: 3878 PGLSEASTTF--YSSPRSPTTTLSP 3900



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 68/309 (22%), Positives = 108/309 (34%), Gaps = 12/309 (3%)

Query: 535  GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
            GST T+    +  A   S  +       THT+    +  ++  EEP     S  S    H
Sbjct: 1920 GSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTH 1979

Query: 594  KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTA 653
               SS  SG +EE    ST S     AT T +  A    ++           S     TA
Sbjct: 1980 FPDSSTTSGRSEE----STASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTA 2035

Query: 654  TSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNH 713
              G       +++S    +    P T+     T++     +  ++H         + P+ 
Sbjct: 2036 LPGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDS 2095

Query: 714  GDSPNLLIADNPQLSALLIGKANGNVGTGTCD-KVNNIHPAVHTKTDHSVASSPSSAIST 772
              +P L        S+       G+  T           P+  + T HS   S  +A+S 
Sbjct: 2096 TTTPGLSRHSTTSHSS------PGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSP 2149

Query: 773  ATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSM 832
             + +  S  Q S    +S  S H+ L   +    G  ++ST+V     S R+T     S 
Sbjct: 2150 GSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASST 2209

Query: 833  SVSICPSST 841
            S  +   ST
Sbjct: 2210 SPGLQGEST 2218



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 73/325 (22%), Positives = 115/325 (35%), Gaps = 33/325 (10%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  S   P   + S +     +S  + LS      P  +T S    +++++  +  + 
Sbjct: 2508 TTLPGSPTTPSLSEKSTTFYTSPRSPDATLS------PATTTSSGVSEESSTSHSQPGST 2561

Query: 631  HLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGC 690
            H T    + P       LS H+ TS    G   T    P+   +  P     T  +S G 
Sbjct: 2562 HTT----AFPDSTTTPGLSRHSTTSHSSPGSTDTT-LLPASTTTSGPSQESTTSHSSPGS 2616

Query: 691  ADVKGLSNHVHQLIADAVSSPNH---GDSPNLLIADNPQLSALLIGKANGNVGTG----T 743
             D          L     S+  H   G +   L  D+   S ++      +  TG    T
Sbjct: 2617 TDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTT 2676

Query: 744  CDKVNNIHPAV---------HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
                ++  P +         H  + H+  S PS+A  TA     +T  RS  S  + + P
Sbjct: 2677 LSPASSTSPGLQGESTTFQTHPASTHTTPSPPSTA--TAPVEESTTYHRSPGSTPTTHFP 2734

Query: 795  HSGLHTVNGEGLGKSQSSTKVD--LPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGK 852
             S   + + E      SS       P ++H +TS    S +  I P STE+     +   
Sbjct: 2735 ASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTT 2794

Query: 853  NGLSNSCILLDKCPPPRPPTSPYPP 877
             GLS +         PR PT+   P
Sbjct: 2795 PGLSEASTTF--YSSPRSPTTTLSP 2817



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 63/273 (23%), Positives = 92/273 (33%), Gaps = 34/273 (12%)

Query: 595  SQSSCLSGPNEEQPLFSTGSAQYHQ---ATSTGIKKANEHLTLPSNSVPQGDADSHLSCH 651
            ++ S  SG  EE   F    A       AT T      E  T PS+S   G   + LS  
Sbjct: 2428 TEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSS---GSTGTTLSPA 2484

Query: 652  TATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSP 711
             +T+ G  G     ES PS+      ET+   G  +      K  + +      DA  SP
Sbjct: 2485 RSTTSGLVG-----ESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSP 2539

Query: 712  -----------------NHGDSPNLLIADNPQLSALLIGKANGNVGTGTCD------KVN 748
                               G +      D+     L       +   G+ D         
Sbjct: 2540 ATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTT 2599

Query: 749  NIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGK 808
               P+  + T HS   S  +A+S  + +  S  Q S    +S  S H+ L   +    G 
Sbjct: 2600 TSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGI 2659

Query: 809  SQSSTKVDLPLASHRSTSQILPSMSVSICPSST 841
             ++ST+V     S R+T     S S  +   ST
Sbjct: 2660 VEASTRVHSSTGSPRTTLSPASSTSPGLQGEST 2692



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 65/309 (21%), Positives = 106/309 (34%), Gaps = 12/309 (3%)

Query: 535  GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
            GST T+    +         +       THT+    +  ++  EEP     S  S    H
Sbjct: 3477 GSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTH 3536

Query: 594  KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTA 653
               SS  SG +EE    ST S     AT T +  A    ++           S     TA
Sbjct: 3537 FPDSSTTSGRSEE----STASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTA 3592

Query: 654  TSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNH 713
              G       +++S    +    P T+     T++     +  ++H         + P+ 
Sbjct: 3593 LPGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDS 3652

Query: 714  GDSPNLLIADNPQLSALLIGKANGNVGTGTCD-KVNNIHPAVHTKTDHSVASSPSSAIST 772
              +P L        S+       G+  T            +  + T HS + S  +A+S 
Sbjct: 3653 TTTPGLSRHSTTSHSS------PGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSP 3706

Query: 773  ATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSM 832
             + +  S  Q S    +S  S H+ L   +    G  ++ST+V     S R+T     S 
Sbjct: 3707 GSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASST 3766

Query: 833  SVSICPSST 841
            S  +   ST
Sbjct: 3767 SPGLQGEST 3775



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 66/319 (20%), Positives = 109/319 (34%), Gaps = 32/319 (10%)

Query: 535  GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
            GST T+    +         +       THT+    +  ++  EEP     S  S    H
Sbjct: 837  GSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTH 896

Query: 594  KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTL-----PSNSVPQGDADSHL 648
               SS  SG +EE    ST S     AT T +  A    ++      ++ +  G  ++  
Sbjct: 897  FPDSSTTSGRSEE----STASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTA 952

Query: 649  SCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAV 708
               + T+ G      T  S P    + +   S     TS+G ++                
Sbjct: 953  LPGSTTTPGLSERSTTFHSSPRSPATTLSPAST----TSSGVSE------------ESTT 996

Query: 709  SSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCD------KVNNIHPAVHTKTDHSV 762
            S    G +      D+     L       +   G+ D            P+  + T HS 
Sbjct: 997  SRSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSS 1056

Query: 763  ASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASH 822
            + S  +A+S  + +  S  Q S    ++  S H+ L   +    G  ++ST+V     S 
Sbjct: 1057 SGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSP 1116

Query: 823  RSTSQILPSMSVSICPSST 841
            R+T     S S  +   ST
Sbjct: 1117 RTTLSPASSTSPGLQGEST 1135



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 66/302 (21%), Positives = 102/302 (33%), Gaps = 36/302 (11%)

Query: 535  GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
            GST T+    +  A   S  +       THT+    +  ++  EEP     S  S    H
Sbjct: 4753 GSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTH 4812

Query: 594  KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNS-------VPQGDADS 646
              +SS  SG +EE       +A +    + GI     H T            +  G  ++
Sbjct: 4813 FPESSTTSGRSEES------TASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGSMET 4866

Query: 647  HLSCHTATSG--GQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLI 704
             L+    T G   +  I+++    P +  S    TS               +S     L 
Sbjct: 4867 TLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTS-------------SSISGEPTSLY 4913

Query: 705  ADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVAS 764
            + A S+       +   +   Q S     K      T +   +     A    T HS   
Sbjct: 4914 SQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHS--- 4970

Query: 765  SPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTV----NGEGLGKSQSSTKVDLPLA 820
             P SA+ST +P+  +    S  S T  +SP S   T     N   +   QS+   D P  
Sbjct: 4971 QPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGF 5030

Query: 821  SH 822
            +H
Sbjct: 5031 TH 5032



 Score = 39.3 bits (90), Expect = 0.026
 Identities = 89/423 (21%), Positives = 162/423 (38%), Gaps = 82/423 (19%)

Query: 465  AQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVR---------PACVEKL 515
            A   ++G+   + T  S P +  +   P       SS + PGV          P   +  
Sbjct: 4348 ASTTSSGVSEESTTSHSRPGSMHTTAFP-------SSTTMPGVSQESTASHSSPGSTDTT 4400

Query: 516  LSSGAFSAGCI-PCGTS--KILGSTDTILLGSNCIAGSESNGNVPYLQQ----NTHTLPH 568
            LS G+ +A  + P  T+     GST+T LL  N  A      + P        +T   P 
Sbjct: 4401 LSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPA 4460

Query: 569  NHTDLN--SSTEEPWRK----------------QLSNSAQG-------LHKSQSSCLSGP 603
              T     S+T + W                  +LS ++ G        H S SS   G 
Sbjct: 4461 GSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGR 4520

Query: 604  NEEQ------PLFSTGSAQYHQATSTGIKK----------ANEHLTLPSNSVPQGDADSH 647
            +EE       P+ +  +    ++T++G+ +          + + +  P ++   G  +  
Sbjct: 4521 SEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEES 4580

Query: 648  LSCHTATSGGQQGIMFTKESKPSKNRSLVPE-TSRHTGDTSNGCADVKGLSNHVHQLIAD 706
             + H++T+        T  S PS   +LV E TS H+   S         S+       +
Sbjct: 4581 TTSHSSTT-------HTISSAPSTTSALVEEPTSYHSSPGSTATTHFPD-SSTTSGRSEE 4632

Query: 707  AVSSPNHGDSPNLLIADNPQLSALLIGKANGN-VGTGTCDKV----NNIHPAVHTKTDHS 761
            + +S +  D+   ++      +++L+G++  + + +G+ +      +   P +  K+  +
Sbjct: 4633 STASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKST-T 4691

Query: 762  VASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLAS 821
              SSPSS  +T   +  +T  RS  S T  +SP   + T       +S +S  V+   A 
Sbjct: 4692 FHSSPSSTPTTHFSASSTTLGRSEESTTVHSSP---VATATTPSPARSTTSGLVEESTAY 4748

Query: 822  HRS 824
            H S
Sbjct: 4749 HSS 4751



 Score = 38.1 bits (87), Expect = 0.057
 Identities = 100/468 (21%), Positives = 172/468 (36%), Gaps = 108/468 (23%)

Query: 465  AQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVR----PACVEKLLSSGA 520
            A   ++G+   + T  S P ++ +   P    T +  VSQ        P   +  LS G+
Sbjct: 3265 ASTTSSGVSEESTTSHSRPGSTHTTAFPGS--TTMPGVSQESTASHSSPGSTDTTLSPGS 3322

Query: 521  FSAGCIPCGTSKIL---GSTDTILLGSNCIAGSESNGNVPYLQQ----NTHTLPHNHTDL 573
             +A  +   ++      GST+T LL  N  A      + P        +T   P   T  
Sbjct: 3323 TTASSLGPESTTFHSGPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTR 3382

Query: 574  N--SSTEEPWRK----------------QLSNSAQG-------LHKSQSSCLSGPNEEQ- 607
               S+T + W                  +LS ++ G        H S SS   G +EE  
Sbjct: 3383 QGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEEST 3442

Query: 608  -----PLFSTGSAQYHQATSTGIKK----------ANEHLTLPSNSVPQGDADSHLSCHT 652
                 P+ +  +    ++T++G+ +          + + +  P +    G  +   + H+
Sbjct: 3443 TVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHS 3502

Query: 653  ATSGGQQGIMFTKESKPSKNRSLVPE-TSRHTGDTSNGCADVKGLSNHVHQLIADAVSSP 711
            +T+        T  S PS   +LV E TS H+   S         S+       ++ +S 
Sbjct: 3503 STT-------HTISSAPSTTSALVEEPTSYHSSPGSTATTHFPD-SSTTSGRSEESTASH 3554

Query: 712  NHGDSPNLLIADNPQLSALLIGKA------NGNVGT----------GTCDKVNNIHPAVH 755
            +  D+   ++      +++L+G++      +G++ T          G  +K    H +  
Sbjct: 3555 SSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPR 3614

Query: 756  TK-TDHSVASSPSSAIS---------------TATPSPKSTEQRSINSVTSLNSPHS--- 796
            +  T  S AS+ SS +S               TA P   +T   S +S TS +SP S   
Sbjct: 3615 SPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDT 3674

Query: 797  GLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSSTEVL 844
             L   +    G SQ ST       SH S+     S   ++ P ST  L
Sbjct: 3675 TLLPASTTTSGSSQEST------TSHSSSG----STDTALSPGSTTAL 3712



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 99/461 (21%), Positives = 154/461 (33%), Gaps = 65/461 (14%)

Query: 446 LEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQP 505
           L +  + F    +   + ++  RTT   +  +++ S  T S S   P   +    S + P
Sbjct: 276 LSEKSTTFYSSPRSPDRTLSPARTT---SSGVSEKS--TTSHSRPGPTHTIAFPDSTTMP 330

Query: 506 GVRPACVEKLLSSGAFSAGCIPCGTSKIL--GSTDTILLGSNCIAGSESNG--NVPYLQQ 561
           GV         S  + ++  IP  T   L  G+T    LG        S G      L  
Sbjct: 331 GV---------SQESTASHSIPGSTDTTLSPGTTTPSSLGPESTTFHSSPGYTKTTRLPD 381

Query: 562 NTHT--LPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSG----------PNEEQPL 609
           NT T  L    T ++SST  P    LS S+   H+ + +              P+     
Sbjct: 382 NTTTSGLLEASTPVHSSTGSP-HTTLSPSSSTTHEGEPTTFQSWPSSKDTSPAPSGTTSA 440

Query: 610 FSTGSAQYHQ-----------ATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQ 658
           F   S  YH            A+ST +  + E  + P +S P   A +     +ATSG  
Sbjct: 441 FVKLSTTYHSSPSSTPTTHFSASSTTLGHSEE--STPVHSSPVATATTPPPARSATSGHV 498

Query: 659 QGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNH----- 713
           +       S  S      PE+S  +G +    A   G + H         ++  H     
Sbjct: 499 EESTAYHRSPGSTQTMHFPESSTTSGHSEES-ATFHGSTTHTKSSTPSTTAALAHTSYHS 557

Query: 714 --GDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAIS 771
             G +      D+  +S           G     K ++  P     T     S+PS  + 
Sbjct: 558 SLGSTETTHFRDSSTIS-----------GRSEESKASHSSPDAMATTVLPAGSTPSVLVG 606

Query: 772 TATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPS 831
            +TPSP S+      ++   ++   GL   +       +S     LP AS  S+     S
Sbjct: 607 DSTPSPISSGSMETTALPG-STTKPGLSEKSTTFYSSPRSPDTTHLP-ASMTSSGVSEES 664

Query: 832 MSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPT 872
            +    P ST       +    GLS         P P   T
Sbjct: 665 TTSHSRPGSTHTTAFPGSTTMPGLSQESTASHSSPGPTDTT 705



 Score = 35.8 bits (81), Expect = 0.29
 Identities = 59/310 (19%), Positives = 112/310 (36%), Gaps = 43/310 (13%)

Query: 573  LNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQ----PLFSTGSAQYHQATSTGIKKA 628
            ++S + E      S +  GL +  ++  S P        P  +T S    ++T++  +  
Sbjct: 4308 ISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPG 4367

Query: 629  NEHLT-LPSNSVPQGDADSHLSCH---------------TATSGGQQGIMFTKESKPSKN 672
            + H T  PS++   G +    + H               TA+S G +   F   S  S  
Sbjct: 4368 SMHTTAFPSSTTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTF-HSSPGSTE 4426

Query: 673  RSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADN-------- 724
             +L+P+ +  +G        V   +   H  ++ A S+   G+S       N        
Sbjct: 4427 TTLLPDNTTASG-LLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAP 4485

Query: 725  PQLSALLIGKANGNVGTGTCDKVNNIHPAVHT--KTDHSVASSPSSAISTATPSP----- 777
            P  ++  +  +  + G+ +     +   +  T  +++ S     S   +  TPSP     
Sbjct: 4486 PTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTT 4545

Query: 778  ------KSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPS 831
                   +T   S  S  +++ P S   +  GE    S SST   +  A   +++ +   
Sbjct: 4546 SGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEP 4605

Query: 832  MSVSICPSST 841
             S    P ST
Sbjct: 4606 TSYHSSPGST 4615



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 78/325 (24%), Positives = 132/325 (40%), Gaps = 41/325 (12%)

Query: 529 GTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNS 588
           G S+I GST    +G N  + S  + + P+   + + +  + T +  ST    +  L +S
Sbjct: 160 GFSQITGSTVNTSIGGNTTSASTPSSSDPFTTFSDYGV--SVTFITGSTAT--KHFLDSS 215

Query: 589 AQGLHKSQSSCL-SGPNEEQPLFSTGSAQY--HQATSTGIKKANEHLTLPSNSVPQGDAD 645
               H  +S+   SGP       +TG+  +  H ATS  +    E  T P  S       
Sbjct: 216 TNSGHSEESTVSHSGPG------ATGTTLFPSHSATSVFV---GEPKTSPITSASM--ET 264

Query: 646 SHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIA 705
           + L   T T+G  +       S  S +R+L P  +     TS+G ++ K  ++H      
Sbjct: 265 TALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPART-----TSSGVSE-KSTTSHSRPGPT 318

Query: 706 DAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASS 765
             ++ P+    P   ++     S  + G  +  +  GT    +++ P   + T H   SS
Sbjct: 319 HTIAFPDSTTMPG--VSQESTASHSIPGSTDTTLSPGTTTP-SSLGP--ESTTFH---SS 370

Query: 766 PSSAISTATPSPKSTE---QRSINSVTSLNSPHSGLH-----TVNGEGLG-KSQSSTKVD 816
           P    +T  P   +T    + S    +S  SPH+ L      T  GE    +S  S+K  
Sbjct: 371 PGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEPTTFQSWPSSKDT 430

Query: 817 LPLASHRSTSQILPSMSVSICPSST 841
            P  S  +++ +  S +    PSST
Sbjct: 431 SPAPSGTTSAFVKLSTTYHSSPSST 455



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 83/377 (22%), Positives = 134/377 (35%), Gaps = 57/377 (15%)

Query: 477  ITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGS 536
            + ++S+P +S S R PH  L+   S ++ G           S   S    P   +    +
Sbjct: 744  LLEASMPVHS-STRSPHTTLSPAGSTTRQGESTT-----FHSWPSSKDTRPAPPT----T 793

Query: 537  TDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSST-----EEPWRKQLSNSAQG 591
            T   +  S    GS S+            +P  H    S+T     E         S Q 
Sbjct: 794  TSAFVEPSTTSHGSPSS------------IPTTHISARSTTSGLVEESTTYHSSPGSTQT 841

Query: 592  LHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCH 651
            +H  +S   SG  EE    S  S  +  +++     A        +S P   A +H    
Sbjct: 842  MHFPESDTTSGRGEESTT-SHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS 900

Query: 652  TATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSP 711
            + TSG  +    +  S+ +    ++P  +R T     G +    +S+   +  A   S+ 
Sbjct: 901  STTSGRSEESTASHSSQDATGTIVLP--ARSTTSVLLGESTTSPISSGSMETTALPGSTT 958

Query: 712  NHGDSP-NLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAI 770
              G S  +     +P+  A  +  A+    +G  ++                 S P S  
Sbjct: 959  TPGLSERSTTFHSSPRSPATTLSPAS-TTSSGVSEESTTSR------------SRPGSTH 1005

Query: 771  STATPSPKSTEQRSINSVTSLNSPHS---GLHTVNGEGLGKSQSSTKVDLPLASHRSTSQ 827
            +TA P   +T   S +S TS +SP S    L   +    G SQ ST       SH S+  
Sbjct: 1006 TTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQEST------TSHSSSG- 1058

Query: 828  ILPSMSVSICPSSTEVL 844
               S   ++ P ST  L
Sbjct: 1059 ---STDTALSPGSTTAL 1072



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 65/304 (21%), Positives = 115/304 (37%), Gaps = 30/304 (9%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P   T      ++T++  +  + 
Sbjct: 3869 TTLPGSTTTPGLSEASTTFYSSPRSPTTTLS------PASMTSLGVGEESTTSRSQPGST 3922

Query: 631  HLTL-PSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNG 689
            H T+ P+++   G ++   + ++++ G  +  +F + +  S  R     T+ H+   S  
Sbjct: 3923 HSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRRE--EPTTFHSRPASTH 3980

Query: 690  C------ADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGT 743
                   +   GL+         + +S   G    L  AD  + S      ++G+ GT  
Sbjct: 3981 TTLFTEDSTTSGLTEE-STAFPGSPASTQTGLPATLTTADLGEESTTF-PSSSGSTGTKL 4038

Query: 744  CDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHS-----GL 798
                +     V   T   +  SPSS  +T  P   +T   S  S T   SP S       
Sbjct: 4039 SPARSTTSGLVGESTPSRL--SPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSP 4096

Query: 799  HTVNGEGLGKSQSSTKVDLPLASHR-----STSQILPSMSVSICPSSTEVLKACRNPGKN 853
             T    G+ + +SST    P ++H      ST+    S   +   SS    +A  +PG  
Sbjct: 4097 ATTTSSGVSE-ESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGST 4155

Query: 854  GLSN 857
              S+
Sbjct: 4156 TASS 4159



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 65/307 (21%), Positives = 116/307 (37%), Gaps = 36/307 (11%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P   T      ++T++  +  + 
Sbjct: 2786 TTLPGSTTTPGLSEASTTFYSSPRSPTTTLS------PASMTSLGVGEESTTSRSQPGST 2839

Query: 631  HLTL-PSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPS---------KNRSLVPETS 680
            H T+ P+++   G ++   + ++++ G  +  +F + +  S          +R     T+
Sbjct: 2840 HSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTT 2899

Query: 681  RHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVG 740
              T D++       GL+         + +S   G    L  AD  + S      ++G+ G
Sbjct: 2900 LFTEDSTTS-----GLTEE-STAFPGSPASTQTGLPATLTTADLGEESTTF-PSSSGSTG 2952

Query: 741  TGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHS---- 796
            T      +     V   T   +  SPSS  +T  P   +T   S  S T   SP S    
Sbjct: 2953 TTLSPARSTTSGLVGESTPSRL--SPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDAT 3010

Query: 797  -GLHTVNGEGLGKSQSSTKVDLPLASHR-----STSQILPSMSVSICPSSTEVLKACRNP 850
                T    G+ + +SST    P ++H      ST+    S   +   SS    +A  +P
Sbjct: 3011 LSPATTTSSGVSE-ESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSP 3069

Query: 851  GKNGLSN 857
            G    S+
Sbjct: 3070 GSTTASS 3076



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 68/313 (21%), Positives = 116/313 (37%), Gaps = 48/313 (15%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P   T      ++T++  +  + 
Sbjct: 1229 TTLPGSTTTPGLSEASTTFYSSPRSPTTTLS------PASMTSLGVGEESTTSRSQPGST 1282

Query: 631  HLTL-PSNSVPQGDADSHLSCHTATSGGQQGIMF--------------TKESKP-SKNRS 674
            H T+ P+++   G ++   + ++++ G  +  +F              T  S+P S + +
Sbjct: 1283 HSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTT 1342

Query: 675  LVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGK 734
            L  E S  +G T    A               + +S   G    L  AD  + S      
Sbjct: 1343 LFTEDSTTSGLTEESTA------------FPGSPASTQTGLPATLTTADLGEESTTF-PS 1389

Query: 735  ANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
            ++G+ GT      +     V   T   +  SPSS  +T  P   +T   S  S T   SP
Sbjct: 1390 SSGSTGTKLSPARSTTSGLVGESTPSRL--SPSSTETTTLPGSPTTPSLSEKSTTFYTSP 1447

Query: 795  HS-----GLHTVNGEGLGKSQSSTKVDLPLASHR-----STSQILPSMSVSICPSSTEVL 844
             S        T    G+ + +SST    P ++H      ST+    S   +   SS    
Sbjct: 1448 RSPDATLSPATTTSSGVSE-ESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSHSSQGST 1506

Query: 845  KACRNPGKNGLSN 857
            +A  +PG    S+
Sbjct: 1507 EATLSPGSTTASS 1519


>gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo
           sapiens]
          Length = 2036

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 75/325 (23%), Positives = 118/325 (36%), Gaps = 33/325 (10%)

Query: 571 TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
           T L  ST  P   + S +     +S ++ LS      P  +T S    ++T++  +  + 
Sbjct: 438 TALPGSTTTPGLSERSTTFHSSPRSPATTLS------PASTTSSGVSEESTTSRSRPGST 491

Query: 631 HLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGC 690
           H T    + P       LS H+ TS    G   T    P+   +  P     T  +S+G 
Sbjct: 492 HTT----AFPDSTTTPGLSRHSTTSHSSPGSTDTT-LLPASTTTSGPSQESTTSHSSSGS 546

Query: 691 ADVKGLSNHVHQLIADAVSSPNH---GDSPNLLIADNPQLSALLIGKANGNVGTG----T 743
            D          L     S+  H   G +   L  D+   S ++      +  TG    T
Sbjct: 547 TDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTT 606

Query: 744 CDKVNNIHPAV---------HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
               ++  P +         H  + H+  S PS+A  TA     +T  RS  S  + + P
Sbjct: 607 LSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTA--TAPVEESTTYHRSPGSTPTTHFP 664

Query: 795 HSGLHTVNGEGLGKSQSSTKVD--LPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGK 852
            S   + + E      SS       P ++H +TS    S +  I P STE+     +   
Sbjct: 665 ASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTT 724

Query: 853 NGLSNSCILLDKCPPPRPPTSPYPP 877
            GLS +         PR PT+   P
Sbjct: 725 PGLSEASTTF--YSSPRSPTTTLSP 747



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 66/319 (20%), Positives = 109/319 (34%), Gaps = 32/319 (10%)

Query: 535 GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
           GST T+    +         +       THT+    +  ++  EEP     S  S    H
Sbjct: 324 GSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTH 383

Query: 594 KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTL-----PSNSVPQGDADSHL 648
              SS  SG +EE    ST S     AT T +  A    ++      ++ +  G  ++  
Sbjct: 384 FPDSSTTSGRSEE----STASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTA 439

Query: 649 SCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAV 708
              + T+ G      T  S P    + +   S     TS+G ++                
Sbjct: 440 LPGSTTTPGLSERSTTFHSSPRSPATTLSPAST----TSSGVSE------------ESTT 483

Query: 709 SSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCD------KVNNIHPAVHTKTDHSV 762
           S    G +      D+     L       +   G+ D            P+  + T HS 
Sbjct: 484 SRSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSS 543

Query: 763 ASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASH 822
           + S  +A+S  + +  S  Q S    ++  S H+ L   +    G  ++ST+V     S 
Sbjct: 544 SGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSP 603

Query: 823 RSTSQILPSMSVSICPSST 841
           R+T     S S  +   ST
Sbjct: 604 RTTLSPASSTSPGLQGEST 622



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 83/377 (22%), Positives = 134/377 (35%), Gaps = 57/377 (15%)

Query: 477 ITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGS 536
           + ++S+P +S S R PH  L+   S ++ G           S   S    P   +    +
Sbjct: 231 LLEASMPVHS-STRSPHTTLSPAGSTTRQGESTT-----FHSWPSSKDTRPAPPT----T 280

Query: 537 TDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSST-----EEPWRKQLSNSAQG 591
           T   +  S    GS S+            +P  H    S+T     E         S Q 
Sbjct: 281 TSAFVEPSTTSHGSPSS------------IPTTHISARSTTSGLVEESTTYHSSPGSTQT 328

Query: 592 LHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCH 651
           +H  +S   SG  EE    S  S  +  +++     A        +S P   A +H    
Sbjct: 329 MHFPESDTTSGRGEESTT-SHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS 387

Query: 652 TATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSP 711
           + TSG  +    +  S+ +    ++P  +R T     G +    +S+   +  A   S+ 
Sbjct: 388 STTSGRSEESTASHSSQDATGTIVLP--ARSTTSVLLGESTTSPISSGSMETTALPGSTT 445

Query: 712 NHGDSP-NLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAI 770
             G S  +     +P+  A  +  A+    +G  ++                 S P S  
Sbjct: 446 TPGLSERSTTFHSSPRSPATTLSPAS-TTSSGVSEESTTSR------------SRPGSTH 492

Query: 771 STATPSPKSTEQRSINSVTSLNSPHS---GLHTVNGEGLGKSQSSTKVDLPLASHRSTSQ 827
           +TA P   +T   S +S TS +SP S    L   +    G SQ ST       SH S+  
Sbjct: 493 TTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQEST------TSHSSSG- 545

Query: 828 ILPSMSVSICPSSTEVL 844
              S   ++ P ST  L
Sbjct: 546 ---STDTALSPGSTTAL 559



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 35/128 (27%), Positives = 53/128 (41%), Gaps = 5/128 (3%)

Query: 755  HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS-- 812
            H+ T H+++S PS+  ++A     ++   S  S+ + + P S   +   E    S SS  
Sbjct: 1431 HSSTTHTISSPPST--TSALVEEPTSYHSSPGSIATTHFPESSTTSGRSEESTASHSSPD 1488

Query: 813  TKVDLPLASHRSTS-QILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPP 871
            T    PL +H +TS +I  S +  I P S E   A         + S IL        P 
Sbjct: 1489 TNGITPLPAHFTTSGRIAESTTFYISPGSMETTLASTATTPGLSAKSTILYTSDLVGEPT 1548

Query: 872  TSPYPPLP 879
            T    P P
Sbjct: 1549 TFYISPSP 1556



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 68/313 (21%), Positives = 116/313 (37%), Gaps = 48/313 (15%)

Query: 571  TDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANE 630
            T L  ST  P   + S +     +S ++ LS      P   T      ++T++  +  + 
Sbjct: 716  TTLPGSTTTPGLSEASTTFYSSPRSPTTTLS------PASMTSLGVGEESTTSRSQPGST 769

Query: 631  HLTL-PSNSVPQGDADSHLSCHTATSGGQQGIMF--------------TKESKP-SKNRS 674
            H T+ P+++   G ++   + ++++ G  +  +F              T  S+P S + +
Sbjct: 770  HSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTT 829

Query: 675  LVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGK 734
            L  E S  +G T    A               + +S   G    L  AD  + S      
Sbjct: 830  LFTEDSTTSGLTEESTA------------FPGSPASTQTGLPATLTTADLGEESTTF-PS 876

Query: 735  ANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSP 794
            ++G+ GT      +     V   T   +  SPSS  +T  P   +T   S  S T   SP
Sbjct: 877  SSGSTGTKLSPARSTTSGLVGESTPSRL--SPSSTETTTLPGSPTTPSLSEKSTTFYTSP 934

Query: 795  HS-----GLHTVNGEGLGKSQSSTKVDLPLASHR-----STSQILPSMSVSICPSSTEVL 844
             S        T    G+ + +SST    P ++H      ST+    S   +   SS    
Sbjct: 935  RSPDATLSPATTTSSGVSE-ESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSHSSQGST 993

Query: 845  KACRNPGKNGLSN 857
            +A  +PG    S+
Sbjct: 994  EATLSPGSTTASS 1006


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 50/246 (20%), Positives = 102/246 (41%), Gaps = 21/246 (8%)

Query: 93  FCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQD 152
           +  LG  +LL  D  KA+  Y++      +   N   L  LGL+Y     +  A +   +
Sbjct: 171 YIMLGKIHLLEGDLDKAIEVYKKAVEFSPE---NTELLTTLGLLYLQLGIYQKAFEHLGN 227

Query: 153 VLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLY 212
            L  DP+  +A    L  G M + + D+  +L  ++  ++ C      +  +  +I   +
Sbjct: 228 ALTYDPTNYKA---ILAAGSMMQTHGDFDVALTKYR--VVAC--AVPESPPLWNNIGMCF 280

Query: 213 ETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQK 272
             ++KY +A       L+  N  A     +L  LG +H  M        + + A  +L  
Sbjct: 281 FGKKKYVAAISC----LKRANYLAPFDWKILYNLGLVHLTMQ-------QYASAFHFLSA 329

Query: 273 SLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPM 332
           ++   P  G+ +  L    +++  +++A  +Y +++   + +     +  VL   Q +  
Sbjct: 330 AINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKK 389

Query: 333 DALQAY 338
           +AL  Y
Sbjct: 390 NALAQY 395


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 46/200 (23%), Positives = 90/200 (45%), Gaps = 24/200 (12%)

Query: 170 LGLMFKVNT--------DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSA 221
           LG++F +NT        +++S  + F+ AL  C      NA++ ++I      +    +A
Sbjct: 447 LGILF-INTLRCVLRSGEWRSEEQLFRSALSVCP----LNAKVHYNIGKNLADKGNQTAA 501

Query: 222 KEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSG 281
              Y + ++    P  V A          +N+  +  +  +   A + L  +++  P+  
Sbjct: 502 IRYYREAVRLN--PKYVHAM---------NNLGNILKERNELQEAEELLSLAVQIQPDFA 550

Query: 282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 341
            +W  LG   +S+ + + A  SYR +I       D + ++G LY   N+ +DAL A+  A
Sbjct: 551 AAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNA 610

Query: 342 VQLDHGHAAAWMDLGTLYES 361
             L   H+ AW ++  L ++
Sbjct: 611 TVLKPEHSLAWNNMIILLDN 630



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 27/113 (23%), Positives = 55/113 (48%)

Query: 268 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
           Q  + +L   P + +  Y +G+  +  G    A   YR+++  +        ++G + ++
Sbjct: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528

Query: 328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKR 380
           +N+  +A +    AVQ+    AAAWM+LG +  S  + + A + Y  A + +R
Sbjct: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 2/128 (1%)

Query: 249 MHHNMDL-VGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQS 307
           +H+N+   + DK  + + AI+Y ++++  +P    +   LG       ++Q+A      +
Sbjct: 484 VHYNIGKNLADKGNQTA-AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLA 542

Query: 308 IDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQD 367
           +      A  W ++G++     +   A Q+Y  A++    +   + +LG LY   N+  D
Sbjct: 543 VQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD 602

Query: 368 AIKCYLNA 375
           A+  + NA
Sbjct: 603 ALNAWRNA 610


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 46/200 (23%), Positives = 90/200 (45%), Gaps = 24/200 (12%)

Query: 170 LGLMFKVNT--------DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSA 221
           LG++F +NT        +++S  + F+ AL  C      NA++ ++I      +    +A
Sbjct: 466 LGILF-INTLRCVLRSGEWRSEEQLFRSALSVCP----LNAKVHYNIGKNLADKGNQTAA 520

Query: 222 KEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSG 281
              Y + ++    P  V A          +N+  +  +  +   A + L  +++  P+  
Sbjct: 521 IRYYREAVRLN--PKYVHAM---------NNLGNILKERNELQEAEELLSLAVQIQPDFA 569

Query: 282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 341
            +W  LG   +S+ + + A  SYR +I       D + ++G LY   N+ +DAL A+  A
Sbjct: 570 AAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNA 629

Query: 342 VQLDHGHAAAWMDLGTLYES 361
             L   H+ AW ++  L ++
Sbjct: 630 TVLKPEHSLAWNNMIILLDN 649



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 27/113 (23%), Positives = 55/113 (48%)

Query: 268 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
           Q  + +L   P + +  Y +G+  +  G    A   YR+++  +        ++G + ++
Sbjct: 488 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 547

Query: 328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKR 380
           +N+  +A +    AVQ+    AAAWM+LG +  S  + + A + Y  A + +R
Sbjct: 548 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 600



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 2/128 (1%)

Query: 249 MHHNMDL-VGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQS 307
           +H+N+   + DK  + + AI+Y ++++  +P    +   LG       ++Q+A      +
Sbjct: 503 VHYNIGKNLADKGNQTA-AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLA 561

Query: 308 IDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQD 367
           +      A  W ++G++     +   A Q+Y  A++    +   + +LG LY   N+  D
Sbjct: 562 VQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD 621

Query: 368 AIKCYLNA 375
           A+  + NA
Sbjct: 622 ALNAWRNA 629


>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
          Length = 1564

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 28/98 (28%), Positives = 46/98 (46%), Gaps = 2/98 (2%)

Query: 266 AIQYLQKSLEADPNSGQSWYFLG--RCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGV 323
           ++  L+K++  D N+   W  LG   CYS IG    A   + +SI   + +A  W ++GV
Sbjct: 810 SLHCLKKAVRLDSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGV 869

Query: 324 LYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYES 361
           LY        A +A+  A  LD  +   W+    + E+
Sbjct: 870 LYLTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEA 907



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 18/48 (37%), Positives = 22/48 (45%)

Query: 316 DTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCN 363
           + W  IGV   +  QP  A  AY  A +L+     AW  L  LYE  N
Sbjct: 41  NAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLANLYEKYN 88



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 16/76 (21%), Positives = 38/76 (50%), Gaps = 2/76 (2%)

Query: 254 DLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEA 313
           D + +K  KE  A+++ +  L+ + N+  +W F+G   + + +   A  +Y+++ +    
Sbjct: 15  DAIRNKEYKE--ALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPD 72

Query: 314 SADTWCSIGVLYQQQN 329
               W  +  LY++ N
Sbjct: 73  QLLAWQGLANLYEKYN 88


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 72/340 (21%), Positives = 139/340 (40%), Gaps = 31/340 (9%)

Query: 72  KAVRCYESLILKAEGK----VESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNA 127
           +AV+ YE  +  A+       ++  +C LG     L ++SKA    +   SL      + 
Sbjct: 652 EAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQ 711

Query: 128 A---FLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAK---EIHLRLGLMFKVNTDYK 181
           A    L  LG ++      + AIK ++  L +       +     +  LG  +++   Y 
Sbjct: 712 AKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYD 771

Query: 182 SSLKHFQLALIDCNPCTLSNAEIQFH--IAHLYETQRKYHSAKEAYEQLLQTENL--PAQ 237
            +L +    L      +    E + H  +A +Y    KY  A + YE+ L          
Sbjct: 772 KALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPS 831

Query: 238 VKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQK--SLEADPNSGQSWYFLGRCYSSIG 295
           ++A V   +G    NM+++ +        +  LQ+    E+  + G+++  LG CY ++G
Sbjct: 832 LEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALG 891

Query: 296 KVQDA------FISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDH--- 346
             ++A      ++S  QS+++ +  A  +  +G  ++       AL  +   + + H   
Sbjct: 892 DYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELG 951

Query: 347 ---GHAAAWMDLGTLYESCNQPQDAIKC---YLNAARSKR 380
                A A+ +LG+L+      + AI C    LN AR  +
Sbjct: 952 EAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMK 991



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 72/332 (21%), Positives = 133/332 (40%), Gaps = 42/332 (12%)

Query: 73   AVRCYESLILKA----EGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAA 128
            A++ YE  +  A    + ++E+  +  LG    +++ Y KAL     Y++ + + ++  +
Sbjct: 733  AIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALG----YHTQELEVYQELS 788

Query: 129  FLYG-------LGLVYFYYNAFHWAIKAFQDVLYV-----DPSFCRAKEIHLRLGLMFKV 176
             L G       L  VY     +  A K +++ L +     DPS     +++  +G+    
Sbjct: 789  DLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSL--EAQVYGNMGITKMN 846

Query: 177  NTDYKSSLKHF--QLALIDC---NPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQT 231
                + ++ +F  QLA++     N   L       ++   YE    Y  A + YEQ L  
Sbjct: 847  MNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906

Query: 232  ENL--PAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
                   Q +A   + LG  H  M  +          +    +  EA  N  Q++  LG 
Sbjct: 907  AQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAF-NKAQAYGELGS 965

Query: 290  CYSSIGKVQDAFISYRQSID-----KSEA-SADTWCSIGVLYQQQNQPMDALQAYICAVQ 343
             +S +G  + A     + ++     K  A  +D  C +G +YQQ  +   ALQ +   +Q
Sbjct: 966  LHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQ 1025

Query: 344  LDHG------HAAAWMDLGTLYESCNQPQDAI 369
            +            A+ +LG  YES    + A+
Sbjct: 1026 IAEETNNPTCQGRAYGNLGLTYESLGTFERAV 1057


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 19/161 (11%)

Query: 96  LGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLY 155
           LGH  +L E+  KAL+ ++    +   ++ NA   YGLG++Y+    F  A   FQ  L 
Sbjct: 613 LGHEFVLTEELDKALACFRNAIRVNPRHY-NA--WYGLGMIYYKQEKFSLAEMHFQKALD 669

Query: 156 VDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL---SNAEIQFHIAHLY 212
           ++P   ++  +   +G++       + +LK  + AL   N   +    N   +FH A + 
Sbjct: 670 INP---QSSVLLCHIGVV-------QHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL 719

Query: 213 ETQRKYHSAKEAYEQLLQ---TENLPAQVKATVLQQLGWMH 250
               KY SA +  E+L Q    E+L   +   V ++LG  H
Sbjct: 720 FANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTH 760



 Score = 37.4 bits (85), Expect = 0.098
 Identities = 19/69 (27%), Positives = 35/69 (50%)

Query: 309 DKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA 368
           D  + S + WC+ G  +  Q +   A++ +  A+Q+D  +A A+  LG  +    +   A
Sbjct: 567 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 626

Query: 369 IKCYLNAAR 377
           + C+ NA R
Sbjct: 627 LACFRNAIR 635



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 50/258 (19%), Positives = 102/258 (39%), Gaps = 24/258 (9%)

Query: 119 LQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNT 178
           L + ++     L  +G  YF  + +  A + F +V  ++       EI+     ++ +  
Sbjct: 497 LPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT--LWHLQK 554

Query: 179 DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQV 238
           D   S+    L  +D N     + E      + +  QR++  A + +++ +Q +  P   
Sbjct: 555 DVALSVLSKDLTDMDKN-----SPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD--PNYA 607

Query: 239 KATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQ 298
            A  L     + H   L  +       A+   + ++  +P    +WY LG  Y    K  
Sbjct: 608 YAYTL-----LGHEFVLTEEL----DKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFS 658

Query: 299 DAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD------HGHAAAW 352
            A + +++++D +  S+   C IGV+     +   AL     A+ +D        H A+ 
Sbjct: 659 LAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASV 718

Query: 353 MDLGTLYESCNQPQDAIK 370
           +     Y+S  Q  + +K
Sbjct: 719 LFANEKYKSALQELEELK 736


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 19/161 (11%)

Query: 96  LGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLY 155
           LGH  +L E+  KAL+ ++    +   ++ NA   YGLG++Y+    F  A   FQ  L 
Sbjct: 607 LGHEFVLTEELDKALACFRNAIRVNPRHY-NA--WYGLGMIYYKQEKFSLAEMHFQKALD 663

Query: 156 VDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL---SNAEIQFHIAHLY 212
           ++P   ++  +   +G++       + +LK  + AL   N   +    N   +FH A + 
Sbjct: 664 INP---QSSVLLCHIGVV-------QHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL 713

Query: 213 ETQRKYHSAKEAYEQLLQ---TENLPAQVKATVLQQLGWMH 250
               KY SA +  E+L Q    E+L   +   V ++LG  H
Sbjct: 714 FANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTH 754



 Score = 37.4 bits (85), Expect = 0.098
 Identities = 19/69 (27%), Positives = 35/69 (50%)

Query: 309 DKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA 368
           D  + S + WC+ G  +  Q +   A++ +  A+Q+D  +A A+  LG  +    +   A
Sbjct: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 620

Query: 369 IKCYLNAAR 377
           + C+ NA R
Sbjct: 621 LACFRNAIR 629



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 50/258 (19%), Positives = 102/258 (39%), Gaps = 24/258 (9%)

Query: 119 LQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNT 178
           L + ++     L  +G  YF  + +  A + F +V  ++       EI+     ++ +  
Sbjct: 491 LPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT--LWHLQK 548

Query: 179 DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQV 238
           D   S+    L  +D N     + E      + +  QR++  A + +++ +Q +  P   
Sbjct: 549 DVALSVLSKDLTDMDKN-----SPEAWCAAGNCFSLQREHDIAIKFFQRAIQVD--PNYA 601

Query: 239 KATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQ 298
            A  L     + H   L  +       A+   + ++  +P    +WY LG  Y    K  
Sbjct: 602 YAYTL-----LGHEFVLTEEL----DKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFS 652

Query: 299 DAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD------HGHAAAW 352
            A + +++++D +  S+   C IGV+     +   AL     A+ +D        H A+ 
Sbjct: 653 LAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASV 712

Query: 353 MDLGTLYESCNQPQDAIK 370
           +     Y+S  Q  + +K
Sbjct: 713 LFANEKYKSALQELEELK 730


>gi|89026265 PREDICTED: mucin 12 [Homo sapiens]
          Length = 978

 Score = 42.0 bits (97), Expect = 0.004
 Identities = 67/302 (22%), Positives = 103/302 (34%), Gaps = 36/302 (11%)

Query: 535 GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
           GST T+    +  A   S  +       THT+    +  ++  EEP     S  S    H
Sbjct: 256 GSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTH 315

Query: 594 KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNS-------VPQGDADS 646
             +SS  SG +EE       +A +    + GI     H T            +  G  ++
Sbjct: 316 FPESSTTSGRSEES------TASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGSMET 369

Query: 647 HLSCHTATSG--GQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLI 704
            L+  T T G   +  I+++    P +  S    TS               +S     L 
Sbjct: 370 TLASTTTTPGLSAKSTILYSSSRSPDQTLSPASMTS-------------SSISGEPTSLY 416

Query: 705 ADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVAS 764
           + A S+       +   +   Q S     K      T +   +     A    T HS   
Sbjct: 417 SQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHS--- 473

Query: 765 SPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTV----NGEGLGKSQSSTKVDLPLA 820
            P SA+ST +P+  +    S  S T  +SP S   T     N   +   QS+   D P  
Sbjct: 474 QPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGF 533

Query: 821 SH 822
           +H
Sbjct: 534 TH 535


>gi|239758148 PREDICTED: similar to mucin 11 [Homo sapiens]
          Length = 587

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 62/281 (22%), Positives = 99/281 (35%), Gaps = 12/281 (4%)

Query: 563 THTLPHNHTDLNSSTEEPWRKQLS-NSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQAT 621
           THT+    +  ++  EEP     S  S    H   SS  SG +EE    ST S     AT
Sbjct: 24  THTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEE----STASHSSQDAT 79

Query: 622 STGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSR 681
            T +  A    ++           S     TA  G       +++S    +    P T+ 
Sbjct: 80  GTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPATTL 139

Query: 682 HTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGT 741
               T++     +  ++H         + P+   +P L        S+       G+  T
Sbjct: 140 SPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSS------PGSTDT 193

Query: 742 GTCD-KVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHT 800
                      P+  + T HS   S  +A+S  + +  S  Q S    +S  S H+ L  
Sbjct: 194 TLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFP 253

Query: 801 VNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSST 841
            +    G  ++ST+V     S R+T     S S  +   ST
Sbjct: 254 DSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGEST 294



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 57/266 (21%), Positives = 92/266 (34%), Gaps = 42/266 (15%)

Query: 562 NTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQA 620
           +THT P   +   +  EE      S  S    H   SS  SG +E+  +F          
Sbjct: 302 STHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIF---------- 351

Query: 621 TSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETS 680
                           +S P     +  S H+ TSG       ++ES  S ++     T+
Sbjct: 352 ----------------HSSPDASGTTPSSAHSTTSG------VSEESSTSHSQPGSTHTT 389

Query: 681 RHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVG 740
                T+      +  ++H  Q   +A        SP    A   ++S     + +    
Sbjct: 390 AFPDSTTTSGLSQEPTTSHSSQGSTEATLDTT--PSPPGTTAAPVEVSTTYHSRPSSTPT 447

Query: 741 TGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHT 800
           T        +  +  + T HS   SP S  +TA P   +T   S  S T  +SP S   T
Sbjct: 448 THFSASSTTLGRSEESTTVHS---SPGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTT 504

Query: 801 VNGEGLGKS----QSSTKVDLPLASH 822
           ++      S    +S+T    P ++H
Sbjct: 505 LSPASTTSSGVSEESTTSHSRPGSTH 530



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 76/373 (20%), Positives = 132/373 (35%), Gaps = 44/373 (11%)

Query: 530 TSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWR--KQLSN 587
           TS +LG + T  + S  +  +   G+       T  L    T  +SS   P       S 
Sbjct: 90  TSVLLGESTTSPISSGSMETTALPGST-----TTPGLSEKSTTFHSSPRSPATTLSPAST 144

Query: 588 SAQGLHKSQSSCLSGPNEEQPLF-----STGSAQYHQATSTGIKKANEHLTLPSNSVPQG 642
           ++ G+ +  ++  S P            +T     H  TS     + +   LP+++   G
Sbjct: 145 TSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSG 204

Query: 643 DADSHLSCH---------------TATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTS 687
            +    + H               TA S GQ+   F   S  S + +L P+++     TS
Sbjct: 205 PSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTF-HSSPGSTHTTLFPDST-----TS 258

Query: 688 NGCADVKGLSNHVHQLIAD--AVSSPNHGDSPNLL---IADNPQLSALLIGKANGNVGTG 742
           +G  +    S  VH          SP    SP L     A     ++     +  +  T 
Sbjct: 259 SGIVEA---STRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 315

Query: 743 TCDKVNNIHPAV-HTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTV 801
             ++    H +   T T H  ASS +S  S  +    S+   S  + +S +S  SG+   
Sbjct: 316 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGVSEE 375

Query: 802 NGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCIL 861
           +     +  S+     P ++  S     P+ S S   S+   L     P   G + + + 
Sbjct: 376 SSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLDT--TPSPPGTTAAPVE 433

Query: 862 LDKCPPPRPPTSP 874
           +      RP ++P
Sbjct: 434 VSTTYHSRPSSTP 446


>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
           sapiens]
          Length = 515

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 260 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 319

Query: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 320 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 349



 Score = 38.1 bits (87), Expect = 0.057
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 214 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 272

Query: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 273 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 315



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)

Query: 22  MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81
           +A+   S +    +++L  +  +   G  + L G  R++E+       +  A   Y+ ++
Sbjct: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 319

Query: 82  LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139
            +    VE+       HF      YS       R+Y   LQ   + N      LGL  FY
Sbjct: 320 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 372

Query: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199
              +   + +F+  L +  +   A ++   LG +     D   + + F+LAL++ N    
Sbjct: 373 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 428

Query: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259
           ++AE   ++A L    RK H   E    LLQT        +++   +   H N   + DK
Sbjct: 429 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 477

Query: 260 ATKESYAIQYLQKSLEADPN 279
                 +    QKS  A P+
Sbjct: 478 IGDLQRSYVAAQKSEAAFPD 497


>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
           sapiens]
          Length = 475

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 220 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 279

Query: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 280 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 309



 Score = 38.1 bits (87), Expect = 0.057
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 174 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 232

Query: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 233 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 275



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)

Query: 22  MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81
           +A+   S +    +++L  +  +   G  + L G  R++E+       +  A   Y+ ++
Sbjct: 224 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 279

Query: 82  LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139
            +    VE+       HF      YS       R+Y   LQ   + N      LGL  FY
Sbjct: 280 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 332

Query: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199
              +   + +F+  L +  +   A ++   LG +     D   + + F+LAL++ N    
Sbjct: 333 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 388

Query: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259
           ++AE   ++A L    RK H   E    LLQT        +++   +   H N   + DK
Sbjct: 389 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 437

Query: 260 ATKESYAIQYLQKSLEADPN 279
                 +    QKS  A P+
Sbjct: 438 IGDLQRSYVAAQKSEAAFPD 457


>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
           sapiens]
          Length = 505

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 21/90 (23%), Positives = 44/90 (48%)

Query: 283 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAV 342
           ++ +L + Y S+ +   A   ++Q +DK        C I  +Y++ N    A + Y   +
Sbjct: 250 TFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVL 309

Query: 343 QLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
           + D+ H  A   +G+ +   +QP+ A++ Y
Sbjct: 310 KQDNTHVEAIACIGSNHFYSDQPEIALRFY 339



 Score = 38.1 bits (87), Expect = 0.057
 Identities = 21/103 (20%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 273 SLEADPNSGQSWYF---LGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN 329
           +L  + +  + W++   +G+CY  +G  ++A   ++ ++ K +   DT+  +  +Y   +
Sbjct: 204 ALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSAL-KQQEMVDTFLYLAKVYVSLD 262

Query: 330 QPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
           QP+ AL  +   +    G       +  +YE  N    A + Y
Sbjct: 263 QPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY 305



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 58/260 (22%), Positives = 103/260 (39%), Gaps = 28/260 (10%)

Query: 22  MAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLI 81
           +A+   S +    +++L  +  +   G  + L G  R++E+       +  A   Y+ ++
Sbjct: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEE----MNNMSSAAEYYKEVL 309

Query: 82  LKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYS--LQADYWKNAAFLYGLGLVYFY 139
            +    VE+       HF      YS       R+Y   LQ   + N      LGL  FY
Sbjct: 310 KQDNTHVEAIACIGSNHF------YSDQPEIALRFYRRLLQMGIY-NGQLFNNLGLCCFY 362

Query: 140 YNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTL 199
              +   + +F+  L +  +   A ++   LG +     D   + + F+LAL++ N    
Sbjct: 363 AQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNN---- 418

Query: 200 SNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDK 259
           ++AE   ++A L    RK H   E    LLQT        +++   +   H N   + DK
Sbjct: 419 NHAEAYNNLAVL--EMRKGH--VEQARALLQT-------ASSLAPHMYEPHFNFATISDK 467

Query: 260 ATKESYAIQYLQKSLEADPN 279
                 +    QKS  A P+
Sbjct: 468 IGDLQRSYVAAQKSEAAFPD 487


>gi|151301154 mucin 6, gastric [Homo sapiens]
          Length = 2439

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 102/486 (20%), Positives = 169/486 (34%), Gaps = 68/486 (13%)

Query: 481  SLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSA--GCIPCGTS-KILGST 537
            S P  ++    P  + + V+  +   + P   +   S+   SA  G IP  T+ K  GST
Sbjct: 1437 SHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGST 1496

Query: 538  DTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTD-----------LNSSTEEPWRKQLS 586
             T    +   +G+ S  +  +    T T  H+HT              + T  P   +  
Sbjct: 1497 HTAPPITPTTSGT-SQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTR 1555

Query: 587  NSAQGLHKSQSS-------CLSGPNEEQPLFSTG--SAQYHQATSTGIKKANEHLTLPSN 637
                  + + SS         S P    P  STG  +A   + T+T    ++   TLP++
Sbjct: 1556 TPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTH 1615

Query: 638  SVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPET------SRHTGDT----S 687
              P   +    S HT  +     +  +         ++ P T      S HT  T    +
Sbjct: 1616 VPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTT 1675

Query: 688  NGCADVKGLSN--------HVHQLI---ADAVSSPNHGDSPNLLIADNPQLSALLIGKAN 736
            +G +      N        H H      A+A S+     +PN      P ++    G + 
Sbjct: 1676 SGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQ 1735

Query: 737  GNVGTGTCDKVNNIHPAVHTKTDH--SVASSPSSAIS-------TATPSPKSTEQRSINS 787
                  T     ++H   HT + H   V S+ +++I+       T TP   +T   S   
Sbjct: 1736 SRSSFSTAKTSTSLHS--HTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRL 1793

Query: 788  VT--SLNSPHSGLHTVNGEG---LGKSQSSTKVDLPLASHRSTSQILPSMSVS-ICPSST 841
             T  + +SP +G   ++  G       Q++T    P   H +    +PS S S + PS+ 
Sbjct: 1794 PTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTH 1853

Query: 842  EVLKACRNPGKNGLSNSCILLDKCPPPRP-----PTSPYPPL-PKDKLNPPTPSIYLENK 895
             V+           S   +     PPP        T   PP+ P       +PS +   K
Sbjct: 1854 TVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAK 1913

Query: 896  RDAFFP 901
                 P
Sbjct: 1914 TSTSLP 1919



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 95/467 (20%), Positives = 163/467 (34%), Gaps = 68/467 (14%)

Query: 527  PCGTSKILGSTDTILLGSNC-IAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQL 585
            P  TS +  ST T++  ++  +A S SN + P     T T+P   T L ++        +
Sbjct: 1449 PFSTSLVTPSTHTVITPTHAQMATSASNHSAP-----TGTIPPP-TTLKATGSTHTAPPI 1502

Query: 586  SNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDAD 645
            + +  G  ++ SS  +          T S  + + T T       + T      P    +
Sbjct: 1503 TPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAHTN 1562

Query: 646  SHLSCHTATSGGQQGIMFTKESKP------SKNRSLVPETSRHTGDTSNGCADVKGLSNH 699
            S  S             FT  S P      S    +   + + T            L  H
Sbjct: 1563 SATSSRPPPP-------FTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTH 1615

Query: 700  VHQLIADAVSSPNHG--DSPNLLIADNPQLSALLIG--------KANGNVGT-------- 741
            V       V+   H      +  +A +  + ++  G        KA G+  T        
Sbjct: 1616 VPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTT 1675

Query: 742  -GTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHT 800
             GT   +++++ A  + + HS  SS   A +T+T +   T      + TS  +P   + T
Sbjct: 1676 SGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITP-----NPTSTGTPPMTVTT 1730

Query: 801  VNGEGLGKSQSSTKVDLPLASHRSTS---QILPSMSVSICPSSTEVLKACRNPGKNGLSN 857
                    S S+ K    L SH S++   ++  + + SI P+ T      R P  +  S 
Sbjct: 1731 SGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTST--GTRTPVAHTTSA 1788

Query: 858  SCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVI 917
            +   L     P P T+  PP     ++   P      +    +P        P +P T  
Sbjct: 1789 TSSRL-----PTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYP-------TPSHPHTT- 1835

Query: 918  RGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGT 964
                  L   +  FST  +  + +  ++   TQ+   A  +  PTGT
Sbjct: 1836 ------LPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGT 1876



 Score = 37.7 bits (86), Expect = 0.075
 Identities = 86/392 (21%), Positives = 133/392 (33%), Gaps = 41/392 (10%)

Query: 468  RTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIP 527
            RT   H  + T S LPT   ++  P G  T +SS                + +     +P
Sbjct: 1779 RTPVAHTTSATSSRLPTPFTTHSPPTGT-TPISSTGPVTATSFQTTTTYPTPSHPHTTLP 1837

Query: 528  C-----GTSKILGSTDTILLGSNCIAGSESN------GNVP-----YLQQNTHTLPHNHT 571
                   TS +  ST T+++ ++    + ++      G +P         +THT P    
Sbjct: 1838 THVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTP 1897

Query: 572  DLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEH 631
              + +++ P     + ++  L    SS  +   E  P  +T     H  TSTG +    H
Sbjct: 1898 TTSGTSQSPSSFSTAKTSTSLPYHTSS--THHPEVTPTSTTNITPKH--TSTGTRTPVAH 1953

Query: 632  LTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCA 691
             T  S+S       +  + H+  +G          +  S   +    T  H   T     
Sbjct: 1954 TTSASSS----RLPTPFTTHSPPTGSSPFSSTGPMTATSFQTTTTYPTPSHPQTT----- 2004

Query: 692  DVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQL--SALLIGKANGNVGTGTCDKVN- 748
                L  HV       V+   H     ++I  + Q+  SA +     G V   T  K   
Sbjct: 2005 ----LPTHVPPFSTSLVTPSTH----TVIITTHTQMATSASIHSTPTGTVPPPTTLKATG 2056

Query: 749  NIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGK 808
            + H A       S  S   S+ STAT S       S     S + P S   T     L  
Sbjct: 2057 STHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSSRPPSSPITTQLPHLSS 2116

Query: 809  SQSSTKVDLPLASHRSTSQILPSMSVSICPSS 840
            + +       L+S  S S   PS   S  PSS
Sbjct: 2117 ATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSS 2148



 Score = 37.4 bits (85), Expect = 0.098
 Identities = 118/553 (21%), Positives = 183/553 (33%), Gaps = 90/553 (16%)

Query: 461  HKEVAQVRTTGIH-NGAITDSSLP---TNSVSNRQP------HGALTRVSSVSQPGVRPA 510
            H EV    TT I  N   T +  P   TNS ++ +P      H   T  S  S  G   A
Sbjct: 1534 HPEVTPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTA 1593

Query: 511  CVEKLLSS--------GAFSAGCIPCGTSKILGSTDTILLGSNC-IAGSESNGNVPYLQQ 561
               K  ++                P  TS +  ST T++  ++  +A S S  ++P    
Sbjct: 1594 TSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMP---- 1649

Query: 562  NTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQAT 621
             T T+P   T L ++        ++ +  G  ++ SS  +          T S  + +AT
Sbjct: 1650 -TGTIPPP-TTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEAT 1707

Query: 622  STGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSR 681
            ST            +N  P   +         TSG  Q       +K S +      ++ 
Sbjct: 1708 STST----------TNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTH 1757

Query: 682  HTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDS---PNLLIADNPQLSALLIGKANGN 738
            H   TS     +    NH        V+      S   P      +P      I  + G 
Sbjct: 1758 HPEVTSTSTTSIT--PNHTSTGTRTPVAHTTSATSSRLPTPFTTHSPPTGTTPIS-STGP 1814

Query: 739  VGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPS------PKSTEQRSINSVTSL- 791
            V T T  +    +P             PS + S  TPS      P  T+  +  S+ S+ 
Sbjct: 1815 V-TATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMP 1873

Query: 792  -------------NSPHSG---LHTVNGEGLGKSQSST-KVDLPLASHRSTS---QILPS 831
                          S H+      T +G     S  ST K    L  H S++   ++ P+
Sbjct: 1874 TGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPT 1933

Query: 832  MSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIY 891
             + +I P  T      R P  +  S S   L     P P T+  PP      +   P   
Sbjct: 1934 STTNITPKHTST--GTRTPVAHTTSASSSRL-----PTPFTTHSPPTGSSPFSSTGPMTA 1986

Query: 892  LENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQL 951
               +    +P        P +P T        L   +  FST  +  + +  ++   TQ+
Sbjct: 1987 TSFQTTTTYP-------TPSHPQTT-------LPTHVPPFSTSLVTPSTHTVIITTHTQM 2032

Query: 952  LQPADENWDPTGT 964
               A  +  PTGT
Sbjct: 2033 ATSASIHSTPTGT 2045


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 40.8 bits (94), Expect = 0.009
 Identities = 63/282 (22%), Positives = 101/282 (35%), Gaps = 29/282 (10%)

Query: 543 GSNCIAGSESNGNVPYLQQNTHTLPHNH-----TDLNSSTEEPWRKQLSNSAQGLHKSQS 597
           GS      +S G+    ++++ +   NH           +  P       ++ G H + S
Sbjct: 294 GSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHG-HSADS 352

Query: 598 SCLSGPN--EEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATS 655
           S  SG    E      T S+     +S G +  + H         Q  ADS  S H+AT 
Sbjct: 353 SRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGH---------QQSADS--SRHSATG 401

Query: 656 GGQQGIMFTKESKPSKNRSLVPETSRHT--GDTSNGCADVK-GLSNHVHQLIADAVSSPN 712
            GQ     +       + S   ++  H+   DT +     K GL    HQ      S   
Sbjct: 402 RGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGER 461

Query: 713 HGDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAI 770
            G S + L  ++ + Q  +     A+G  GT T  +  + H      + HS +      I
Sbjct: 462 SGRSGSSLYQVSTHEQPDS-----AHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTI 516

Query: 771 STATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS 812
                S +   Q S +  +   S HSG H  +    G+S +S
Sbjct: 517 RGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDAS 558



 Score = 39.3 bits (90), Expect = 0.026
 Identities = 66/308 (21%), Positives = 108/308 (35%), Gaps = 29/308 (9%)

Query: 517  SSGAFSAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNH-----T 571
            SS A S+G    G  +  G   +   GS+    S+S G+    ++ + +   NH      
Sbjct: 2538 SSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQE 2597

Query: 572  DLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQA--TSTGIKKAN 629
             L   +  P   Q   +  G H + SS  SG    Q      +A  H+   +S G +  +
Sbjct: 2598 QLRDGSRHPRSHQEDRAGHG-HSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGS 2656

Query: 630  EHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNG 689
             H         Q  ADS  S H+    GQ             + S   +   H+ D+   
Sbjct: 2657 HH---------QQSADS--SRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQ 2705

Query: 690  CADVKGLSN---HVHQLIADAVSSPNHGDSPNLL--IADNPQLSALLIGKANGNVGTGTC 744
                 G +      HQ  A   S    G S + L  ++ + Q  +     ++G  G  T 
Sbjct: 2706 SVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSES-----SHGWTGPSTR 2760

Query: 745  DKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGE 804
             +  + H      + HS +      I     S +   Q   +  +  +S HSG H  +  
Sbjct: 2761 GRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTT 2820

Query: 805  GLGKSQSS 812
              G+S +S
Sbjct: 2821 SQGRSDAS 2828



 Score = 37.4 bits (85), Expect = 0.098
 Identities = 62/281 (22%), Positives = 102/281 (36%), Gaps = 27/281 (9%)

Query: 543  GSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSG 602
            GS+    S+S G+    ++ + +   NH   + S +E  R   S   +  H+ ++    G
Sbjct: 2240 GSSVSQDSDSEGHSEDSERRSGSASRNH---HGSAQEQSRDG-SRHPRSHHEDRAG--HG 2293

Query: 603  PNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSN------SVPQGDADSHLSCHTATSG 656
             + E    S  S  +H   S+G + A+ H    S+      S  Q  ADS  S H+    
Sbjct: 2294 HSAES---SRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADS--SRHSGIGH 2348

Query: 657  GQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSN---HVHQLIADAVSSPNH 713
            GQ             + S   ++  H+ D+        G +      HQ      S+   
Sbjct: 2349 GQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRS 2408

Query: 714  GDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAIS 771
            G S + L  ++ + Q  +     A+G  GT T  +  + H      + HS +      I 
Sbjct: 2409 GRSGSFLYQVSTHEQSES-----AHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQDTIH 2463

Query: 772  TATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS 812
                S     Q S        S HSG H  +    G+S +S
Sbjct: 2464 GHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDAS 2504



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 57/282 (20%), Positives = 99/282 (35%), Gaps = 29/282 (10%)

Query: 543  GSNCIAGSESNGNVPYLQQNTHTLPHNHT-----DLNSSTEEPWRKQLSNSAQGLHKSQS 597
            GS+    S+S G+    ++ + +   NH           +  P       +  G H ++S
Sbjct: 3536 GSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHG-HSAES 3594

Query: 598  SCLSGPNEEQPLFSTGSAQYHQA--TSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATS 655
            S  SG +  +      +A  H+   +S G +  + H         Q  ADS  S H+   
Sbjct: 3595 SRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHH---------QQSADS--SRHSGIG 3643

Query: 656  GGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSN---HVHQLIADAVSSPN 712
             GQ             + S   ++  H+ D+        G +      HQ      S+  
Sbjct: 3644 HGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGR 3703

Query: 713  HGDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAI 770
             G S + L  ++ + Q  +     A+G  G  T  +  + H      + HS +      I
Sbjct: 3704 SGRSGSFLYQVSTHEQSES-----AHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTI 3758

Query: 771  STATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS 812
                 S +   Q S +  +   S HSG H  +    G+S +S
Sbjct: 3759 RGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDAS 3800



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 61/290 (21%), Positives = 101/290 (34%), Gaps = 29/290 (10%)

Query: 535  GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNH-----TDLNSSTEEPWRKQLSNSA 589
            GS  +   GS+    S+S G+    ++ + +   NH       L   +  P   Q   + 
Sbjct: 2880 GSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAG 2939

Query: 590  QGLHKSQSSCLSGPNEEQPLFSTGSAQYHQA--TSTGIKKANEHLTLPSNSVPQGDADSH 647
             G H + SS  SG    Q      +A  H+   +S G +  + H         Q  ADS 
Sbjct: 2940 HG-HSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHH---------QQSADS- 2988

Query: 648  LSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSN---HVHQLI 704
             S H+    GQ             + S   +   H+ D+        G +      HQ  
Sbjct: 2989 -SRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQES 3047

Query: 705  ADAVSSPNHGDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSV 762
            A   S    G S + L  ++ + Q  +     ++G  G  T  +  + H      + HS 
Sbjct: 3048 ARGRSGETSGHSGSFLYQVSTHEQSES-----SHGWTGPSTRGRQGSRHEQAQDSSRHSA 3102

Query: 763  ASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS 812
            +      I     S +   Q   +  +  +S HSG H  +    G+S +S
Sbjct: 3103 SQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDAS 3152



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 65/299 (21%), Positives = 108/299 (36%), Gaps = 35/299 (11%)

Query: 529  GTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHT-----DLNSSTEEPWRK 583
            G  +  GS  +   GS+    S+S G+    ++ + +   NH           +  P   
Sbjct: 929  GQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSH 988

Query: 584  QLSNSAQGLHKSQSSCLSG-PNEEQPLFSTGSAQYHQATST-GIKKANEHLTLPSNS--- 638
                +  G H + SS  SG P+ E       ++ + QA S+ G +  + H     +S   
Sbjct: 989  HEDRAGHG-HSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHS 1047

Query: 639  -VPQGDADSHL--SCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKG 695
             +P+  A S +  S H  +SG Q       +S+     S     S H  D         G
Sbjct: 1048 GIPRRQASSAVRDSGHWGSSGSQ-----ASDSEGHSEESDTQSVSGHGQD---------G 1093

Query: 696  LSNHVHQLIADAVSSPNHGDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPA 753
                 HQ  A   S    G S + +  ++ + Q  +     A+G   T T  +  + H  
Sbjct: 1094 PHQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSES-----AHGRTRTSTGRRQGSHHEQ 1148

Query: 754  VHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS 812
                + HS +      I     S +   Q S +  +   S HSG H  +    G+S +S
Sbjct: 1149 ARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDAS 1207



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 62/306 (20%), Positives = 104/306 (33%), Gaps = 24/306 (7%)

Query: 517 SSGAFSAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNH-----T 571
           SS A S+     G  +  G   +   GS+    S+S G+    ++ + +   NH      
Sbjct: 592 SSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQE 651

Query: 572 DLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQA--TSTGIKKAN 629
                +  P       +  G H + SS  SG    Q   S  +A  H+   +S G +  +
Sbjct: 652 QSRDGSRHPRSHHEDRAGHG-HSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGS 710

Query: 630 EHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNG 689
            H    ++S          S H+ T  GQ             + S   ++  H+ D+   
Sbjct: 711 RHQLQSADS----------SRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQ 760

Query: 690 CADVKGLSNH---VHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDK 746
                G + H    HQ  A   S      S + L   +    +     ++G  G  T  +
Sbjct: 761 SVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQS---ESSHGWTGPSTGVR 817

Query: 747 VNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGL 806
             + H      + HS +      I     S +   Q S +  +   S HSG H  +    
Sbjct: 818 QGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQ 877

Query: 807 GKSQSS 812
           G+S +S
Sbjct: 878 GRSDAS 883



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 55/277 (19%), Positives = 93/277 (33%), Gaps = 28/277 (10%)

Query: 572  DLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEH 631
            D +S       ++LS SA   H   S   S      P F       H  ++   +++  H
Sbjct: 1273 DSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTH 1332

Query: 632  LTLPSN---------SVPQGDADSHLSCH--TATSGGQQGIMFTKESKPSKNR------- 673
             T  S+                + H S H  +A S    GI   + S   ++        
Sbjct: 1333 HTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSG 1392

Query: 674  SLVPETSRHTGDTSNGCADVKGLSN---HVHQLIADAVSSPNHGDSPNLL--IADNPQLS 728
            S V  +  H+ D+        G +      H+  A   S  + G S + L  ++ + Q  
Sbjct: 1393 SQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSE 1452

Query: 729  ALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSV 788
            +      +G     T  +  + H      + HS +      I     S +   Q S +  
Sbjct: 1453 S-----THGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQ 1507

Query: 789  TSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRST 825
            +   S HSG H  +    G+S +S     P ++ R T
Sbjct: 1508 SVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQT 1544



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 59/282 (20%), Positives = 98/282 (34%), Gaps = 27/282 (9%)

Query: 529  GTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNH-----TDLNSSTEEPWRK 583
            G  +  GS  +   GS+     +S G+    ++ + +   NH           +  P   
Sbjct: 1577 GQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSH 1636

Query: 584  QLSNSAQGLHKSQSSCLSGPNEEQPLFS--TGSAQYHQATSTGIKKANEHLTLPSNSVPQ 641
            Q   ++ G H ++SS  SG    +        S+Q    +S G +  + H     +S   
Sbjct: 1637 QEDRASHG-HSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDS 1695

Query: 642  GDADSHLSCHTATSG--GQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNH 699
            G      S     SG  G  G     ++  S+  S   E S     +++G A   G    
Sbjct: 1696 GTGRRQDSSVVGDSGNRGSSG----SQASDSEGHS---EESDTQSVSAHGQA---GPHQQ 1745

Query: 700  VHQLIADAVSSPNHGDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTK 757
             HQ      S    G S + L  ++ + Q  +     A+G  G  T  +  + H      
Sbjct: 1746 SHQESTRGQSGERSGRSGSFLYQVSTHEQSES-----AHGRTGPSTGGRQRSRHEQARDS 1800

Query: 758  TDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLH 799
            + HS +      I     S +   Q S    +  +S HSG H
Sbjct: 1801 SRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSH 1842



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 53/223 (23%), Positives = 79/223 (35%), Gaps = 38/223 (17%)

Query: 611  STGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCH--TATSGGQQGIMFTKESK 668
            S  S   H  TS+G + A+ H    S+       + H S H  +A S    GI       
Sbjct: 3271 SRQSGTRHAETSSGGQAASSHEQARSSP-----GERHGSRHQQSADSSRHSGI------- 3318

Query: 669  PSKNRSLVPETSRHTGDTSNGCADVKG---------LSNH--------VHQLIADAVSSP 711
            P    S     SRH G + +  +D +G         +S H         HQ  A   S  
Sbjct: 3319 PRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGG 3378

Query: 712  NHGDSPNLL--IADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSA 769
              G S + L  ++ + Q  +     A+G   T T  +  + H      + HS +      
Sbjct: 3379 RSGRSGSFLYQVSTHEQSES-----AHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDT 3433

Query: 770  ISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSS 812
            I     S +   Q S    +   S HSG H  +    G+S +S
Sbjct: 3434 IRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDAS 3476


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score = 40.4 bits (93), Expect = 0.012
 Identities = 23/98 (23%), Positives = 50/98 (51%)

Query: 279 NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAY 338
           N  ++W  LG    S  K+ +A  +YR ++      AD   ++G+L Q+ ++  +AL  Y
Sbjct: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYY 550

Query: 339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAA 376
             A+      A+A+++ G +  +  + ++A + +L  +
Sbjct: 551 KLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588



 Score = 35.8 bits (81), Expect = 0.29
 Identities = 65/320 (20%), Positives = 124/320 (38%), Gaps = 44/320 (13%)

Query: 97  GHFNLLLEDYSKALSAYQRYYSLQADYWKN--AAFLYGLGLVYFYYNAFHWAIKAFQDVL 154
           G+   +L+  SK   A   Y +  A Y+++  A  LY LGL+    + F  A+  ++  +
Sbjct: 497 GNLGNVLKSQSKISEAESAYRN--ALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAI 554

Query: 155 YVDPSFCRAKEIHLRLGLMF----KVNTDYKSSLKHFQLA---LIDCNPCTLSNAEIQFH 207
              P+   A   +L  G++     +     ++ LK  ++    L D +    S     ++
Sbjct: 555 GSRPTLASA---YLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYN 611

Query: 208 IAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQL---GWM---------HHNMDL 255
           +  LY  Q  Y  A   Y++ +Q   +P Q     L  +    +M         H  M+ 
Sbjct: 612 LGKLYHEQGHYEEALSVYKEAIQ--KMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMES 669

Query: 256 VGDKAT----------------KESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQD 299
           +  K                  ++S A +   K++E DP  G  +   G+      ++ +
Sbjct: 670 LRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIE 729

Query: 300 AFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLY 359
           A    +++ +      D   +   + +Q +    A + Y  A +L   + AA M+LG + 
Sbjct: 730 AAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL 789

Query: 360 ESCNQPQDAIKCYLNAARSK 379
               + Q A   YL A + K
Sbjct: 790 HLNGRLQKAEANYLRALQLK 809


>gi|239754668 PREDICTED: mucin 12 [Homo sapiens]
          Length = 1952

 Score = 40.0 bits (92), Expect = 0.015
 Identities = 66/302 (21%), Positives = 102/302 (33%), Gaps = 36/302 (11%)

Query: 535  GSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLS-NSAQGLH 593
            GST T+    +  A   S  +       THT+    +  ++  EEP     S  S    H
Sbjct: 1227 GSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTH 1286

Query: 594  KSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNS-------VPQGDADS 646
              +SS  SG +EE       +A +    + GI     H T            +  G  ++
Sbjct: 1287 FPESSTTSGRSEES------TASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGSMET 1340

Query: 647  HLSCHTATSG--GQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLI 704
             L+    T G   +  I+++    P +  S    TS               +S     L 
Sbjct: 1341 TLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTS-------------SSISGEPTSLY 1387

Query: 705  ADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVAS 764
            + A S+       +   +   Q S     K      T +   +     A    T HS   
Sbjct: 1388 SQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHS--- 1444

Query: 765  SPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTV----NGEGLGKSQSSTKVDLPLA 820
             P SA+ST +P+  +    S  S T  +SP S   T     N   +   QS+   D P  
Sbjct: 1445 QPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGF 1504

Query: 821  SH 822
            +H
Sbjct: 1505 TH 1506



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 79/382 (20%), Positives = 139/382 (36%), Gaps = 46/382 (12%)

Query: 477  ITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGS 536
            + ++S+P +S S R PH  L+   S ++ G          S+    A   P  TS  +  
Sbjct: 665  LLEASMPVHS-STRSPHTTLSPAGSTTRQGESTTFHSWPSSNDTRPAP--PTTTSAFVEP 721

Query: 537  TDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSST-----EEPWRKQLSNSAQG 591
            + T            S+G+         ++P  H    S+T     E         S Q 
Sbjct: 722  STT------------SHGS-------PSSIPTTHISARSTTSGLVEESTTYHSSPGSTQT 762

Query: 592  LHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCH 651
            +H  +S   SG  EE    S  S  +  +++     A        +S P   A +H    
Sbjct: 763  MHFPESDTTSGRGEESTT-SHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS 821

Query: 652  TATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSP 711
            + TSG  +  + +  S+ +    ++P  +R T     G +    +S+   +  A   S+ 
Sbjct: 822  STTSGRSEESIASHSSQDATGTIVLP--ARSTNSVLLGESTTSPISSGSMETTALPGSTT 879

Query: 712  NHGDSP-NLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAI 770
              G S  +     +P+  A  +  A+    +G  ++    H            S P S  
Sbjct: 880  TPGLSERSTTFHSSPRSPATTLSPAS-TTSSGVSEESTTSH------------SRPGSTH 926

Query: 771  STATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILP 830
            +TA P   +T   S +S TS +SP S   T+                P++S  + +  LP
Sbjct: 927  TTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTXLVGEPTTSPISSGSTETTALP 986

Query: 831  --SMSVSICPSSTEVLKACRNP 850
              + +  +   ST    + R+P
Sbjct: 987  GSTTTAGLSEKSTTFYSSPRSP 1008



 Score = 35.8 bits (81), Expect = 0.29
 Identities = 98/461 (21%), Positives = 154/461 (33%), Gaps = 65/461 (14%)

Query: 446 LEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQP 505
           L +  + F    +   + ++  RTT   +  +++ S  T S S   P   +    S + P
Sbjct: 197 LSEKSTTFYSSPRSPDRTLSPARTT---SSGVSEKS--TTSHSRPGPTHTIAFPDSTTMP 251

Query: 506 GVRPACVEKLLSSGAFSAGCIPCGTSKIL--GSTDTILLGSNCIAGSESNG--NVPYLQQ 561
           GV         S  + ++  IP  T   L  G+T    LG        S G      L  
Sbjct: 252 GV---------SQESTASHSIPGSTDTTLSPGTTTPSSLGPESTTFHSSPGYTKTTRLPD 302

Query: 562 NTHT--LPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSG----------PNEEQPL 609
           NT T  L    T ++SST  P    LS ++   H+ + +              P+     
Sbjct: 303 NTTTSGLLEASTPVHSSTGSP-HTTLSPASSTTHEGEPTTFQSWPSSKDTSPAPSGTTSA 361

Query: 610 FSTGSAQYHQ-----------ATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQ 658
           F   S  YH            A+ST +  + E  + P +S P   A +     +ATSG  
Sbjct: 362 FVKLSTTYHSSPSSTPTTHFSASSTTLGHSEE--STPVHSSPVATATTPPPARSATSGHV 419

Query: 659 QGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNH----- 713
           +       S  S      PE+S  +G +    A   G + H         ++  H     
Sbjct: 420 EESTAYHRSPGSTQTMHFPESSTTSGHSEES-ATFHGSTTHTKSSTPSTTAALAHTSYHS 478

Query: 714 --GDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAIS 771
             G +      D+  +S           G     K ++  P     T     S+PS  + 
Sbjct: 479 SLGSTETTHFRDSSTIS-----------GRSEESKASHSSPDAMATTVLPAGSTPSVLVG 527

Query: 772 TATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPS 831
            +TPSP S+      ++   ++   GL   +       +S     LP AS  S+     S
Sbjct: 528 DSTPSPISSGSMETTALPG-STTKPGLSEKSTTFYSSPRSPDTTHLP-ASMTSSGVSEES 585

Query: 832 MSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPT 872
            +    P ST       +    GLS         P P   T
Sbjct: 586 TTSHSRPGSTHTTAFPGSTTMPGLSQESTASHSSPGPTDTT 626



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 78/325 (24%), Positives = 132/325 (40%), Gaps = 41/325 (12%)

Query: 529 GTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNS 588
           G S+I GST    +G N  + S  + + P+   + + +  + T +  ST    +  L +S
Sbjct: 81  GFSQITGSTVNTSIGGNTTSASTPSSSDPFTTFSDYGV--SVTFITGSTAT--KHFLDSS 136

Query: 589 AQGLHKSQSSCL-SGPNEEQPLFSTGSAQY--HQATSTGIKKANEHLTLPSNSVPQGDAD 645
               H  +S+   SGP       +TG+  +  H ATS  +    E  T P  S       
Sbjct: 137 TNSGHSEESTVSHSGPG------ATGTTLFPSHSATSVFV---GEPKTSPITSASM--ET 185

Query: 646 SHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIA 705
           + L   T T+G  +       S  S +R+L P  +     TS+G ++ K  ++H      
Sbjct: 186 TALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPART-----TSSGVSE-KSTTSHSRPGPT 239

Query: 706 DAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASS 765
             ++ P+    P   ++     S  + G  +  +  GT    +++ P   + T H   SS
Sbjct: 240 HTIAFPDSTTMPG--VSQESTASHSIPGSTDTTLSPGTTTP-SSLGP--ESTTFH---SS 291

Query: 766 PSSAISTATPSPKSTE---QRSINSVTSLNSPHSGLH-----TVNGEGLG-KSQSSTKVD 816
           P    +T  P   +T    + S    +S  SPH+ L      T  GE    +S  S+K  
Sbjct: 292 PGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPASSTTHEGEPTTFQSWPSSKDT 351

Query: 817 LPLASHRSTSQILPSMSVSICPSST 841
            P  S  +++ +  S +    PSST
Sbjct: 352 SPAPSGTTSAFVKLSTTYHSSPSST 376


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 39.7 bits (91), Expect = 0.020
 Identities = 29/114 (25%), Positives = 49/114 (42%)

Query: 262 KESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSI 321
           K+  AI  L+ S++  P    ++  L    +   + ++A   Y+  I     S+D   + 
Sbjct: 455 KKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNY 514

Query: 322 GVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
           GV       P  A+  Y  A++L   H  A ++LG LY S  +   A + Y  A
Sbjct: 515 GVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRA 568



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 49/213 (23%), Positives = 91/213 (42%), Gaps = 18/213 (8%)

Query: 96  LGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLY 155
           LG     L + S A   Y+R  +LQ  +   A  L  LG +Y+    +  A++ +Q+   
Sbjct: 548 LGRLYRSLGENSMAEEWYKR--ALQVAH--KAEILSPLGALYYNTGRYEEALQIYQEAAA 603

Query: 156 VDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQ 215
           + PS    +E+ L L  +  V    K + K     + +   C     E    ++ +Y  Q
Sbjct: 604 LQPS---QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGC----LECYRLLSAIYSKQ 656

Query: 216 RKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLE 275
             +  A +A ++ LQ +    +V + +    G      +L+ DKA  ESY +     +++
Sbjct: 657 ENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLL-DKAF-ESYRV-----AVQ 709

Query: 276 ADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSI 308
            +P+  Q+W  +G      GK   A   Y +++
Sbjct: 710 LNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742



 Score = 37.7 bits (86), Expect = 0.075
 Identities = 46/210 (21%), Positives = 86/210 (40%), Gaps = 28/210 (13%)

Query: 202 AEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKAT 261
           A+    +A L   Q ++  A+E Y+  ++  N P             +H+N  +      
Sbjct: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIK--NCPDSSD---------LHNNYGVFLVDTG 522

Query: 262 KESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSI 321
               A+ + Q++++  P+   +   LGR Y S+G+   A   Y++++  +   A+    +
Sbjct: 523 LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-KAEILSPL 581

Query: 322 GVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA------------- 368
           G LY    +  +ALQ Y  A  L        + L  +     Q ++A             
Sbjct: 582 GALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETG 641

Query: 369 -IKCY--LNAARSKRCSNTSTLAARIKFLQ 395
            ++CY  L+A  SK+ ++   L A  K LQ
Sbjct: 642 CLECYRLLSAIYSKQENHDKALDAIDKALQ 671



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 46/233 (19%), Positives = 94/233 (40%), Gaps = 56/233 (24%)

Query: 163 AKEIHLRLGLMFKVNTDY-KSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSA 221
           + ++H   G+ F V+T   + ++ H+Q A I  +P   S+     ++  LY +  +   A
Sbjct: 507 SSDLHNNYGV-FLVDTGLPEKAVAHYQQA-IKLSP---SHHVAMVNLGRLYRSLGENSMA 561

Query: 222 KEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSG 281
           +E Y++ LQ  +     KA +L  LG +++N         +   A+Q  Q++    P+  
Sbjct: 562 EEWYKRALQVAH-----KAEILSPLGALYYNTG-------RYEEALQIYQEAAALQPSQR 609

Query: 282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQN------------ 329
           +    L +  + +G+ ++A       + +     + +  +  +Y +Q             
Sbjct: 610 ELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKA 669

Query: 330 ---QPMD-----------------------ALQAYICAVQLDHGHAAAWMDLG 356
              +P D                       A ++Y  AVQL+   A AWM++G
Sbjct: 670 LQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMG 722


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,968,015
Number of Sequences: 37866
Number of extensions: 2636463
Number of successful extensions: 14247
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 161
Number of HSP's that attempted gapping in prelim test: 12909
Number of HSP's gapped (non-prelim): 1174
length of query: 1347
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1233
effective length of database: 13,930,794
effective search space: 17176669002
effective search space used: 17176669002
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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