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Search of human proteins with 32698824
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32698824 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
(252 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32698824 low density lipoprotein receptor-related protein 5-l... 530 e-151
gi|209447022 low density lipoprotein receptor-related protein 5-... 530 e-151
gi|119709832 low density lipoprotein receptor-related protein 5 ... 399 e-111
gi|148727288 low density lipoprotein receptor-related protein 6 ... 329 2e-90
gi|157384998 low density lipoprotein receptor-related protein 4 ... 203 1e-52
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 176 2e-44
gi|93102379 low density lipoprotein-related protein 1B precursor... 161 6e-40
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 144 1e-34
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 135 3e-32
gi|61744471 low density lipoprotein receptor-related protein 8 i... 132 2e-31
gi|61744467 low density lipoprotein receptor-related protein 8 i... 132 2e-31
gi|66082554 low density lipoprotein receptor-related protein 8 i... 132 2e-31
gi|65301119 low density lipoprotein receptor-related protein 8 i... 132 2e-31
gi|144953895 nidogen 2 precursor [Homo sapiens] 127 7e-30
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 126 2e-29
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 126 2e-29
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 125 4e-29
gi|4507157 sortilin-related receptor containing LDLR class A rep... 122 3e-28
gi|115298674 nidogen 1 precursor [Homo sapiens] 120 9e-28
gi|226498382 tetratricopeptide repeat domain 5 [Homo sapiens] 30 1.5
gi|112807226 hypothetical protein LOC91748 [Homo sapiens] 29 3.4
gi|6005705 G protein-coupled receptor 182 [Homo sapiens] 29 3.4
gi|44890062 hypothetical protein LOC91748 [Homo sapiens] 29 3.4
gi|33589848 transferrin receptor 2 [Homo sapiens] 29 4.5
gi|169208029 PREDICTED: hypothetical protein [Homo sapiens] 28 7.6
gi|239755684 PREDICTED: hypothetical protein [Homo sapiens] 28 9.9
gi|239750147 PREDICTED: hypothetical protein [Homo sapiens] 28 9.9
gi|239744457 PREDICTED: hypothetical protein [Homo sapiens] 28 9.9
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 530 bits (1366), Expect = e-151
Identities = 252/252 (100%), Positives = 252/252 (100%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Query: 241 PGLAAPSRAWNC 252
PGLAAPSRAWNC
Sbjct: 241 PGLAAPSRAWNC 252
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 530 bits (1366), Expect = e-151
Identities = 252/252 (100%), Positives = 252/252 (100%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Query: 241 PGLAAPSRAWNC 252
PGLAAPSRAWNC
Sbjct: 241 PGLAAPSRAWNC 252
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 399 bits (1024), Expect = e-111
Identities = 193/231 (83%), Positives = 209/231 (90%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+EG+VYWTDDEV AIRRAYLDGSGAQTL+NT+INDPD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 383 LEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEV 442
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
T LN TS KILVSED+DEPRAIALHP MGL YW DWGENP+I+ ANLD QE RVLVNASL
Sbjct: 443 TRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASL 502
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
GWPNGLALDLQEGKLYWGDAKTDKIE I+VD TKR+TLL+DKLPHIF FTLLGDFIYWT
Sbjct: 503 GWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 562
Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
WQ SI+RVHKVKA+RDVIIDQLPDLMGLKAVNV KVVGTNP ADRNGG +
Sbjct: 563 WQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCS 613
Score = 191 bits (484), Expect = 7e-49
Identities = 97/244 (39%), Positives = 144/244 (59%), Gaps = 4/244 (1%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGA--QTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
+G VYWTD AI++ YL+ +GA Q ++ + + PD +A +WV + LYWT + T IE
Sbjct: 74 KGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIE 133
Query: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
V LN TS K+L +D+D+PRAIAL P G YW DWGE P I+RA +D +++V++
Sbjct: 134 VANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSD 193
Query: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
+ WPNGL +DL+E KLYW DAK I ++D + RQ +++ L H F TL GD +YWT
Sbjct: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
Query: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADR-NGGAATCASSR 237
WQ SI +K R I+ L M ++ ++ ++ + + NGG +
Sbjct: 254 DWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLS 313
Query: 238 PTQP 241
P++P
Sbjct: 314 PSEP 317
Score = 161 bits (407), Expect = 6e-40
Identities = 83/226 (36%), Positives = 126/226 (55%), Gaps = 3/226 (1%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
H+YWTD + I RA+++GS + ++ ++ P+ +AV+W+ ++LYW TGT IEV L
Sbjct: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
Query: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
+ ++LV D+D PR++AL P G YW +WG P I RA +D LV+ +G
Sbjct: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRA 806
Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
N L +D + +LYW D T+ IE+ ++ +R ++ D LPH F T D+IYWT W
Sbjct: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNL 865
Query: 184 HSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228
HSI+R K NR +I L +M + + + G N NG
Sbjct: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNG 911
Score = 99.0 bits (245), Expect = 4e-21
Identities = 76/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND-------PDDIAVNWVARSLYWTHT 53
++ +YW D I+RA DG+ Q + T ++ P D++++ +R+L+WT
Sbjct: 987 LDKFIYWVDGRQ-NIKRAKDDGT--QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCE 1043
Query: 54 GTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP-EIKRANLDRQEL 112
T I V L+ + +++ D D+PRAI ++ E G Y+ + + +I+RA LD E
Sbjct: 1044 ATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTER 1103
Query: 113 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
VL L P L +D GKL+W DA +IE+ + R TL + T+L
Sbjct: 1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL 1163
Query: 173 GDFIYWTAWQHHSIKRVHKVKAN-RDVIIDQLPDLMGLKAVNVDKV--VGTNPHADRNGG 229
G +YW Q I+RV K + R I ++ L G+ AV + +P A NGG
Sbjct: 1164 GKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGG 1223
Query: 230 AA-TCASSRPTQPGLAAP 246
+ C + P + P
Sbjct: 1224 CSHICIAKGDGTPRCSCP 1241
Score = 34.7 bits (78), Expect = 0.081
Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 21/229 (9%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
+YWTD + +I G + I + + P DI V R ++ HT E C
Sbjct: 250 LYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFF-HTRCEEDNGGC-- 306
Query: 65 STSHKILVSEDMDE-----PRAIALHP-----EMGLTYWIDWGENPEIKRANLDRQELRV 114
SH L+S P + L + G + +++R +LD +
Sbjct: 307 --SHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTD 364
Query: 115 LVNASLGWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFT 170
+V + +A+D EG +YW D + I +D + QTL+ ++ P
Sbjct: 365 IVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVD 424
Query: 171 LLGDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
+ +YWT I+ +R +++ + DL +A+ + V+G
Sbjct: 425 WVARNLYWTDTGTDRIEVTRLNGTSRKILVSE--DLDEPRAIALHPVMG 471
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 329 bits (843), Expect = 2e-90
Identities = 154/246 (62%), Positives = 190/246 (77%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+EG++YWTDDEV AIRR+++DGSG+Q ++ +I PD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
T LN T KIL+SED++EPRAI L P +G YW DWGE P+I+RA LD + VLVN SL
Sbjct: 430 TRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSL 489
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
GWPNGLALD EGK+YWGDAKTDKIE ++ D T R+ L++DK+PHIF FTLLGD++YWT
Sbjct: 490 GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 549
Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
WQ SI+RVHK A R+VIIDQLPDLMGLKA NV +V+G+NP A+ NGG + RP
Sbjct: 550 WQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQG 609
Query: 241 PGLAAP 246
A P
Sbjct: 610 LRCACP 615
Score = 177 bits (450), Expect = 6e-45
Identities = 92/243 (37%), Positives = 137/243 (56%), Gaps = 5/243 (2%)
Query: 3 GHVYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
G +YW+D AI+R + + Q ++ + + PD +A +W+ LYWT + T IEV+
Sbjct: 63 GLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVS 122
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
L+ + K+L +++D+PRAIAL P G YW DWGE P+I+RA +D +++N+ +
Sbjct: 123 NLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIY 182
Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
WPNGL LD +E KLYW DAK + I ++D T RQ ++K LPH F TL D +YWT W
Sbjct: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
Query: 182 QHHSIKRVHKVKAN--RDVIIDQLPDLMGLKAVNVDKVV-GTNPHADRNGGAATCASSRP 238
HSI +K R++ D + M + A + + TNP NGG + P
Sbjct: 243 STHSILACNKYTGEGLREIHSD-IFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP 301
Query: 239 TQP 241
+P
Sbjct: 302 VKP 304
Score = 166 bits (421), Expect = 1e-41
Identities = 85/228 (37%), Positives = 132/228 (57%), Gaps = 3/228 (1%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
+ +YWTD + I RA+++GS + ++ ++ P+ +AV+W+ ++LYW TGT IEV+
Sbjct: 673 DNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVS 732
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
L+ ++LV +D+D PRA+AL P G YW +WG P+I RA +D E LV ++G
Sbjct: 733 KLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVG 791
Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
NGL +D + +LYW D T+ IE+ ++ R+ ++ D LPH F T D+IYWT W
Sbjct: 792 RANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNRE-VIADDLPHPFGLTQYQDYIYWTDW 850
Query: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228
SI+R +K NR +I L +M + + + G N A NG
Sbjct: 851 SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNG 898
Score = 109 bits (273), Expect = 2e-24
Identities = 71/242 (29%), Positives = 122/242 (50%), Gaps = 12/242 (4%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND------PDDIAVNWVARSLYWTHTG 54
++ +YW D IR+A DGS T++ + + P D++++ +R +YWT
Sbjct: 975 LDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA 1034
Query: 55 TEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELR 113
T I VT L+ S +++ + D PRA+ ++PE G Y+ + E +P+I+RA LD E
Sbjct: 1035 TNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTERE 1094
Query: 114 VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLG 173
VL + L P LALD + GKL+W D+ +IE+ + R L + T+
Sbjct: 1095 VLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
Query: 174 DFIYWTAWQHHSIKRV----HKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGG 229
+++YW Q I+++ + + I QL D+ +K +N+ + +P A NGG
Sbjct: 1155 NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQE-YRQHPCAQDNGG 1213
Query: 230 AA 231
+
Sbjct: 1214 CS 1215
Score = 63.5 bits (153), Expect = 2e-10
Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 3/114 (2%)
Query: 70 ILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALD 129
+L ED+ AI P G YW D E I+R+ +D + +V A + P+G+A+D
Sbjct: 353 VLQLEDIRHAIAIDYDPVEGYIYWTD-DEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411
Query: 130 LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAW 181
LYW D TD+IE ++ T R+ L+ + L P + ++YWT W
Sbjct: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW 465
Score = 60.8 bits (146), Expect = 1e-09
Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 5/146 (3%)
Query: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQE-LRVLVNA 118
V N + +V +++ A+ GL YW D E IKR ++ E ++ +V +
Sbjct: 34 VDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA-IKRTEFNKTESVQNVVVS 92
Query: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFI 176
L P+GLA D KLYW D++T++IE ++D + R+ L +L P F+
Sbjct: 93 GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
Query: 177 YWTAW-QHHSIKRVHKVKANRDVIID 201
YWT W + I+R ++R +II+
Sbjct: 153 YWTDWGEVPKIERAGMDGSSRFIIIN 178
Score = 33.9 bits (76), Expect = 0.14
Identities = 53/271 (19%), Positives = 98/271 (36%), Gaps = 58/271 (21%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
E +YW D ++ I ++ LDG+ Q ++ + P A+ LYWT T H +
Sbjct: 193 EQKLYWADAKLNFIHKSNLDGTNRQAVVKGSL--PHPFALTLFEDILYWTDWST-HSILA 249
Query: 62 CLNSTSHKIL-VSEDMDEPRAI----------ALHP------------------------ 86
C T + + D+ P I A +P
Sbjct: 250 CNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCA 309
Query: 87 --------------EMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQ- 131
+ G T + +++R +LD + +V + +A+D
Sbjct: 310 CPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP 369
Query: 132 -EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSIKR 188
EG +YW D + I +D + Q ++ ++ H + + +YWT I+
Sbjct: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429
Query: 189 VHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
R ++I + DL +A+ +D +VG
Sbjct: 430 TRLNGTMRKILISE--DLEEPRAIVLDPMVG 458
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 203 bits (517), Expect = 1e-52
Identities = 102/247 (41%), Positives = 148/247 (59%), Gaps = 2/247 (0%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
EG VYW+D + I RA LDGS + +I T + D +AV+ + R +YWT TGT IEV
Sbjct: 1092 EGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVG 1151
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
L+ + K+LV +++D PRAI L+ EMG YW DWGEN +++R+ +D + VL+N +LG
Sbjct: 1152 NLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLG 1211
Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
WPNGL +D +L W DA T++IEA ++ R TL+ + H + TLL +IYWT W
Sbjct: 1212 WPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYWTDW 1270
Query: 182 QHHSIKRVHKVKANRDVII-DQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Q SI R K + +++ LP LM ++AV+ + +G N RNGG + RP+
Sbjct: 1271 QTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG 1330
Query: 241 PGLAAPS 247
A P+
Sbjct: 1331 FSCACPT 1337
Score = 196 bits (497), Expect = 2e-50
Identities = 101/247 (40%), Positives = 145/247 (58%), Gaps = 2/247 (0%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
++G VY+TD + IRRA L+GS +T+I + D +AV+WVAR+LYWT TG IE
Sbjct: 1395 VDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1454
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
+ L+ + K+L++ +DEPRAIA+ P G +W DWG +I+RANLD E +VL+N L
Sbjct: 1455 SRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDL 1514
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
GWPNGL LD ++YW DA D+IE+ ++ RQ L+ + H F T +IYWT
Sbjct: 1515 GWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIYWTD 1573
Query: 181 WQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPT 239
WQ SI+RV K N++ ++ + LM + V+ + GTN NGG +R +
Sbjct: 1574 WQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARAS 1633
Query: 240 QPGLAAP 246
A P
Sbjct: 1634 DFVCACP 1640
Score = 190 bits (482), Expect = 1e-48
Identities = 90/244 (36%), Positives = 140/244 (57%), Gaps = 1/244 (0%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
+ HVYWTD I RA DG+G + +++T + P +A++WV LYWT GT+ IEV
Sbjct: 784 DDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVA 843
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
+ + +L+ E++D PR I + P G YW DWG +P+I+RA +D +V+++++L
Sbjct: 844 NTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLT 903
Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
WPNGLA+D +LYW DA IE +D +KR+ L+ +LPH F TL G+ IYWT W
Sbjct: 904 WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDW 963
Query: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
Q SI+ ++ +R+ + + L +LM + + + + P A NGG + P
Sbjct: 964 QTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNP 1023
Query: 241 PGLA 244
G +
Sbjct: 1024 SGFS 1027
Score = 172 bits (436), Expect = 2e-43
Identities = 84/227 (37%), Positives = 132/227 (58%), Gaps = 2/227 (0%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
V+W+D + I RA L+GS + +++T + P +AV+WV LYWT +GT IEV L+
Sbjct: 482 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 541
Query: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
K+L+ +++++PRAIALHP G YW DWG P I+ +++D R++ + L WPN
Sbjct: 542 GAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPN 601
Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
GL +D ++YW DAK IE ++D + R+ ++ LPH F T+ D +YWT W
Sbjct: 602 GLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTK 661
Query: 185 SIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDK-VVGTNPHADRNGG 229
SI +K N+++I ++L M + ++ + G N D NGG
Sbjct: 662 SINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGG 708
Score = 58.9 bits (141), Expect = 4e-09
Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 15/120 (12%)
Query: 1 MEGHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
MEG +YWTD I + +DGSG + + +T + P+ + +++ R +YW IE
Sbjct: 564 MEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIE 623
Query: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDW------------GENPEIKRANL 107
L+ + K ++S+ + P AI + + YW DW G+N EI R L
Sbjct: 624 RANLDGSHRKAVISQGLPHPFAITVFEDS--LYWTDWHTKSINSANKFTGKNQEIIRNKL 681
Score = 41.6 bits (96), Expect = 7e-04
Identities = 47/224 (20%), Positives = 82/224 (36%), Gaps = 51/224 (22%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
+YW D + I RA LDGS + +I+ + P A+ SLYWT T+ I
Sbjct: 612 MYWVDAKHHVIERANLDGSHRKAVISQGL--PHPFAITVFEDSLYWTDWHTKSINSANKF 669
Query: 65 STSHKILVSEDMDEPRAI-ALHPE------------------------------------ 87
+ ++ ++ + P I LHP+
Sbjct: 670 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Query: 88 --------MGLTYWIDWGENPEIKRANLDRQELR--VLVNASLGWPNGLALDLQEGKLYW 137
L ++ + +I+R + D ++L V+ A + L D ++ +YW
Sbjct: 730 KISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYW 789
Query: 138 GDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWT 179
D TD I D T ++ ++ L P + + +YWT
Sbjct: 790 TDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWT 833
Score = 36.6 bits (83), Expect = 0.021
Identities = 45/227 (19%), Positives = 82/227 (36%), Gaps = 54/227 (23%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT------------- 51
+YW D + I A LDGS + LI +++ P + +YWT
Sbjct: 917 LYWADAGMKTIEFAGLDGSKRKVLIGSQL--PHPFGLTLYGERIYWTDWQTKSIQSADRL 974
Query: 52 ---------------------HTGTEHIEVTCL---NSTSHKILVSEDMDE-----PRAI 82
H + C SH L S + P I
Sbjct: 975 TGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGI 1034
Query: 83 ALHPE-----MGLTYWIDWGENPEIKRANLDRQ---ELRVLVNASLGWPNGLALDLQEGK 134
L + G+ ++ + +I+ +LD ++ V +N ++ + +D QEGK
Sbjct: 1035 NLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGK 1094
Query: 135 LYWGDAKTDKIEAISVDETKRQTLLKDKLPHI--FRFTLLGDFIYWT 179
+YW D+ +I ++D ++ + ++ L +G +YWT
Sbjct: 1095 VYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWT 1141
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 176 bits (446), Expect = 2e-44
Identities = 92/242 (38%), Positives = 130/242 (53%), Gaps = 5/242 (2%)
Query: 2 EGHVYWTDDEVWA--IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
E +YWTD IRR +L+GS Q L T +++PD +AV+WV +LYW G + IE
Sbjct: 3068 EQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIE 3127
Query: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
V+ LN +LVS + EPRA+ + + G YW DWG++ I R +D V+V+
Sbjct: 3128 VSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTK 3187
Query: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
+ WPNGL LD ++YW DA+ D IE S+D + R +L +PHIF TL D++YWT
Sbjct: 3188 ITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWT 3247
Query: 180 AWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNV--DKVVGTNPHADRNGGAATCASS 236
W+ SI R HK N+ ++I L M L + V +P NGG +
Sbjct: 3248 DWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLL 3307
Query: 237 RP 238
P
Sbjct: 3308 SP 3309
Score = 173 bits (438), Expect = 1e-43
Identities = 92/235 (39%), Positives = 136/235 (57%), Gaps = 15/235 (6%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
+YW D + I RA D + + ++ I + IAV+W+A ++YWT G + IEV LN
Sbjct: 1936 IYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLN 1995
Query: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
+ +++S+ +D+PRAI +HPE G +W +WG+ P I+R+ LD E VLVN S+ WPN
Sbjct: 1996 GSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPN 2055
Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
G+++D Q+GKLYW DA+TDKIE I ++ R+ +L +F ++ DFIYW+ H
Sbjct: 2056 GISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTH 2115
Query: 184 --HSIKRVHKVKANRDVIIDQLP-------DLMGLKAVNVDKVVGTNPHADRNGG 229
SIKR ++D D +P L +K N D+ GTN A NGG
Sbjct: 2116 ANGSIKR-----GSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGG 2165
Score = 124 bits (311), Expect = 8e-29
Identities = 75/252 (29%), Positives = 133/252 (52%), Gaps = 16/252 (6%)
Query: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH-IEVT 61
G +Y+ D + I R +DG+ +T++ I++ + +AV+W+ +LYWT G + I V
Sbjct: 571 GFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVA 630
Query: 62 CLNSTSH--KILVSEDMDEPRAIALHPEMGLTYWIDWGENPE------IKRANLDRQELR 113
L + K L+ M PRAI + P G YW DW E+P+ ++RA +D
Sbjct: 631 RLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRD 690
Query: 114 VLVNA-SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTL 171
+ V + ++ WPNGL+LD+ G+LYW DA D+IE I ++ T R+ + + +L H F
Sbjct: 691 IFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCH 750
Query: 172 LGDFIYWTAWQHHSIKRVHK----VKANRDVIIDQLPDLMGLKAVNV-DKVVGTNPHADR 226
G++++WT ++ S+ R+ + ++ + P + ++ + + VGTN
Sbjct: 751 HGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN 810
Query: 227 NGGAATCASSRP 238
NGG ++ + P
Sbjct: 811 NGGCSSLCLATP 822
Score = 121 bits (304), Expect = 5e-28
Identities = 72/240 (30%), Positives = 122/240 (50%), Gaps = 10/240 (4%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQT----LINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+YWTD I R L +GA T +I + P+ +AV+W+A ++YW + + IEV
Sbjct: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVL--VN 117
L+ T L++ D++ PRAIAL P G+ +W DW + P I+ A++ R +
Sbjct: 1371 AKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRET 1430
Query: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
S GWPNGL +D E ++ W DA++D I + D + +L+ + L H F TL G
Sbjct: 1431 GSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGE 1490
Query: 176 IYWTAWQHHSIKRVHKVKANRDVIIDQL-PDLMGLKAVNVDKVVGTNPHADRNGGAATCA 234
+YWT W+ +++ + +K + ++ + L+ + + + NGG C+
Sbjct: 1491 VYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCS 1550
Score = 119 bits (298), Expect = 3e-27
Identities = 67/206 (32%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLIN---------------TKINDPDDIAVNWVARS 47
G VYWT+ I L + T N + + P IA++WVA +
Sbjct: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971
Query: 48 LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
+YWT +G + IEV + + K L+S +DEP AI + P G YW DWG +P+I+ A +
Sbjct: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAM 4031
Query: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPH 165
D LV ++ WP GLA+D +LYW DAK I +I ++ T K L H
Sbjct: 4032 DGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSH 4091
Query: 166 IFRFTLLGDFIYWTAWQHHSIKRVHK 191
F + D+IY + ++ + ++HK
Sbjct: 4092 PFSIDVFEDYIYGVTYINNRVFKIHK 4117
Score = 107 bits (267), Expect = 1e-23
Identities = 68/235 (28%), Positives = 119/235 (50%), Gaps = 13/235 (5%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT--HTGTEHIE 59
E VYW+D AI+RA+++G+G +T+++ + + +AV+WV+R+L+WT T + I
Sbjct: 1626 EQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQIN 1685
Query: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
V L+ S K V + +++P + +HP G YW D G+N I AN+D +L +
Sbjct: 1686 VARLDG-SFKNAVVQGLEQPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQ 1741
Query: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIY 177
G P GLA+D E KLYW + I ++D + + + ++ +L ++GD ++
Sbjct: 1742 KG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW 1800
Query: 178 WTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKV----VGTNPHADRNG 228
W + K + V++ L+ V + + GTNP + NG
Sbjct: 1801 WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNG 1855
Score = 97.4 bits (241), Expect = 1e-20
Identities = 69/235 (29%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
++++D I++ DGS T++ + + +A + +LYWT T I ++
Sbjct: 2255 IFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
Query: 65 STS------HKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVN 117
T ++ D PRA L L +W +W E +P I RA L + L+
Sbjct: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
Query: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
+ PNGLA+D + KLY+ DA DKIE D + R +LK + H F + G+ I+
Sbjct: 2374 KDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIF 2433
Query: 178 WTAWQHHSIKRVHK-VKANRDVIIDQLPDL-MGLKAV-NVDKVVGTNPHADRNGG 229
WT W +++R +K V +N ++ +P MG+ AV N +P NGG
Sbjct: 2434 WTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGG 2488
Score = 89.4 bits (220), Expect = 3e-18
Identities = 48/182 (26%), Positives = 99/182 (54%), Gaps = 7/182 (3%)
Query: 29 INTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEM 88
I+ ++ + +A++W+ + Y+ + I V N + L+ ++ P+ IAL P M
Sbjct: 275 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAM 334
Query: 89 GLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAI 148
G ++ D+G+ P+++R ++D Q LV++ + +P+G+ LDL +YW DA D IE +
Sbjct: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
Query: 149 SVDETKRQTLLKDKL-PHIFRFTLLGDFIYWT------AWQHHSIKRVHKVKANRDVIID 201
+ RQT+++ L H++ T+ +++Y T A Q S+ RV++ + ++
Sbjct: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454
Query: 202 QL 203
++
Sbjct: 455 RV 456
Score = 50.8 bits (120), Expect = 1e-06
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 5/157 (3%)
Query: 48 LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
LY H G I + N S ++ I H E YW+D G + I RA
Sbjct: 1894 LYSVHEGIRGIPLDP-NDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS-TISRAKR 1951
Query: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIF 167
D+ +V +G G+A+D G +YW D D IE ++ + R ++ L
Sbjct: 1952 DQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPR 2011
Query: 168 RFTLLGD--FIYWTAW-QHHSIKRVHKVKANRDVIID 201
T+ + +++WT W Q+ I+R R V+++
Sbjct: 2012 AITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN 2048
Score = 50.1 bits (118), Expect = 2e-06
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 74 EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
E++ PRA+ H E G Y+ D + I R +D E ++ + G+A+D
Sbjct: 556 ENLMNPRALDFHAETGFIYFAD-TTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGD 614
Query: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQ 182
LYW G KT + + R+TL++ K+ H + L ++YWT W+
Sbjct: 615 NLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
Score = 48.9 bits (115), Expect = 4e-06
Identities = 31/120 (25%), Positives = 50/120 (41%), Gaps = 16/120 (13%)
Query: 81 AIALHPEMGLTYWIDWGEN--------PEIKRANLDRQELRV------LVNASLGWPNGL 126
A+ +H + G YW +W P +R ++ L + L P G+
Sbjct: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963
Query: 127 ALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAWQHH 184
A+D G +YW D+ D IE + R+TL+ + PH L +YW+ W +H
Sbjct: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023
Score = 38.5 bits (88), Expect = 0.006
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 8/116 (6%)
Query: 3 GHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
G V++TD ++ + R +DG L+++KI P I ++ V+R +YW ++IEV
Sbjct: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVN 117
+ ++ + I + GLT + ++ AN ++ + VN
Sbjct: 395 DYEGKGRQTII-------QGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVN 443
Score = 38.1 bits (87), Expect = 0.007
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWT- 179
P L + G +Y+ D + I +D T+R+T+LKD + ++ + +GD +YWT
Sbjct: 561 PRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTD 620
Query: 180 --AWQHHSIKRVHKVKANRDVIID 201
+ S+ R+ K R +I+
Sbjct: 621 DGPKKTISVARLEKAAQTRKTLIE 644
Score = 33.9 bits (76), Expect = 0.14
Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 18/193 (9%)
Query: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT-----GTEH 57
G VYWTD + +A T++ P D+ V +R + G
Sbjct: 1489 GEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGP 1548
Query: 58 IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTY----WIDWGENPEIKRANLDRQELR 113
CL + + + + P + LH + Y ++ + EI+ +LD
Sbjct: 1549 CSHLCLINYNRTVSCAC----PHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYN 1604
Query: 114 VLVNASLGWPNGLAL---DLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP--HIFR 168
+++ ++ + + + D +E ++YW D +T I+ ++ T +T++ LP H
Sbjct: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
Query: 169 FTLLGDFIYWTAW 181
+ ++WT++
Sbjct: 1665 VDWVSRNLFWTSY 1677
Score = 30.8 bits (68), Expect = 1.2
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 5/55 (9%)
Query: 93 WIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALD--LQEGKLYWGDAKTDKI 145
+I + EI+R +L + + VLV G N +ALD L + LYW D DKI
Sbjct: 1270 FIIFSNRHEIRRIDLHKGDYSVLVP---GLRNTIALDFHLSQSALYWTDVVEDKI 1321
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 161 bits (407), Expect = 6e-40
Identities = 87/230 (37%), Positives = 133/230 (57%), Gaps = 5/230 (2%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
+YWTD I RA D + + +I + + IAV+W+A ++YWT G IEV LN
Sbjct: 1924 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 1983
Query: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
+ +++S+ +D+PR+IA+HPE GL +W +WG+ P I +A LD E VLV+ + WPN
Sbjct: 1984 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 2043
Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWT--AW 181
G+++D +E KLYW DA+TDKIE I ++ R+ +L +F + G +IYW+ A
Sbjct: 2044 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAH 2103
Query: 182 QHHSIKRVHKVKANRDVII--DQLPDLMGLKAVNVDKVVGTNPHADRNGG 229
+ S++R HK A + + +L +K N + GTN A NGG
Sbjct: 2104 ANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGG 2153
Score = 130 bits (327), Expect = 1e-30
Identities = 75/245 (30%), Positives = 128/245 (52%), Gaps = 10/245 (4%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTG-TEHIEVTC 62
++Y+ D + I R +DG+ +T++ +++ + IAV+W+ +LYWT+ G + I V
Sbjct: 569 YIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVAR 628
Query: 63 LN--STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP------EIKRANLDRQELRV 114
L S S K L+ +M PR I + P G YW DW E+ I++A +D ++
Sbjct: 629 LEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQI 688
Query: 115 LVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK-LPHIFRFTLLG 173
V + + WPNGL LD LYW DA D IE + ++ T R+ + + L H F + G
Sbjct: 689 FVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG 748
Query: 174 DFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATC 233
++++WT + + SI ++ + + ++ + P L GL+ + K G N NGG +T
Sbjct: 749 NYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTL 808
Query: 234 ASSRP 238
+ P
Sbjct: 809 CLAIP 813
Score = 118 bits (295), Expect = 6e-27
Identities = 66/193 (34%), Positives = 100/193 (51%), Gaps = 7/193 (3%)
Query: 2 EGHVYWTDDEV---WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHI 58
E +YW D I R L+GS + + NT + P+ +AV+W+ ++LYW+ T I
Sbjct: 3054 EEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRII 3111
Query: 59 EVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNA 118
EV+ LN ILVS+ + PR ++L P+ G YWID E P I R +D V++
Sbjct: 3112 EVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIET 3171
Query: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYW 178
+ P L +D +LYW D + IE ++D + R + +P + TL D+IYW
Sbjct: 3172 KISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 3229
Query: 179 TAWQHHSIKRVHK 191
T + S+ R HK
Sbjct: 3230 TDGKTKSLSRAHK 3242
Score = 114 bits (285), Expect = 8e-26
Identities = 61/196 (31%), Positives = 103/196 (52%), Gaps = 9/196 (4%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKIND----PDDIAVNWVARSLYWTHTGTEHIEV 60
+YWTD I R L SG + I + P+ + V+W+A ++YW + + IEV
Sbjct: 1302 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 1361
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVLVN-- 117
L+ + L++ M+ PRAIAL P G+ +W DW N P I+ A++ + +
Sbjct: 1362 AKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDM 1421
Query: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
+ WPNGL +D E ++ W DA++D I + D T +++ + L H F +L G
Sbjct: 1422 KTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE 1481
Query: 176 IYWTAWQHHSIKRVHK 191
+YWT W+ +++ + +K
Sbjct: 1482 VYWTDWRTNTLSKANK 1497
Score = 95.5 bits (236), Expect = 4e-20
Identities = 60/234 (25%), Positives = 113/234 (48%), Gaps = 8/234 (3%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
E +YWTD + I+RA+++G+G +T+I+ I +AV+WV+R+LYW + + ++
Sbjct: 1617 EERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQIN 1676
Query: 62 CLN-STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
S K + +D+P+ +A HP G YW D I AN+D ++L +
Sbjct: 1677 VARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTINMANMDGSNSKILFQ-NQ 1732
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIYW 178
P GL++D E KLYW + I ++D + + +K++L T++ ++W
Sbjct: 1733 KEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWW 1792
Query: 179 TAWQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
+ K N ++ ++ ++ +K + + G+N NGG +
Sbjct: 1793 ADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCS 1846
Score = 82.8 bits (203), Expect = 3e-16
Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 18/181 (9%)
Query: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEH---------------IEVTCLNSTSHKILV 72
LI + P DIAV+WVA ++YWT H I V LN + L+
Sbjct: 3963 LICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022
Query: 73 SEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQE 132
+ EP AIA++P+ G+ YW G++ I+ A +D R+LV +L P GLA+D
Sbjct: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFS 4082
Query: 133 GKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPHIFRFTLLGDFIYWTAWQHHSIKRVH 190
++YW D + I ++ D + + K L H R + D+IY A + + RV
Sbjct: 4083 ERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY-GAGPKNGVFRVQ 4141
Query: 191 K 191
K
Sbjct: 4142 K 4142
Score = 80.5 bits (197), Expect = 1e-15
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 12/213 (5%)
Query: 28 LINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNST-------SHKILVSEDMDEPR 80
+I + + +A + +LYWT + T I ++ T I +SED D P
Sbjct: 2263 VIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSED-DHPH 2321
Query: 81 AIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGD 139
+AL L +W +W E +P I R+ L + +V+V+ + PNGL +D + KLY+ D
Sbjct: 2322 VLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSD 2381
Query: 140 AKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVI 199
KIE D ++R ++K + ++I+W+ W +I R +K I
Sbjct: 2382 GSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKI 2441
Query: 200 I--DQLPDLMGLKAV-NVDKVVGTNPHADRNGG 229
+ D MG+ AV N +P A NGG
Sbjct: 2442 LRSDIPHQPMGIIAVANDTNSCELSPCALLNGG 2474
Score = 75.1 bits (183), Expect = 5e-14
Identities = 38/154 (24%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Query: 39 IAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE 98
+A++W+ R+LY+ + I V N + L+ ++ P+AIA+ P G ++ D+G
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
Query: 99 NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL 158
+++R ++D ++++ P LALDL +YW D D + + R T+
Sbjct: 348 VAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTV 407
Query: 159 LKDK-LPHIFRFTLLGDFIYWTAWQHHSIKRVHK 191
++ + + H++ T+ D++Y T +++I R+++
Sbjct: 408 IQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR 441
Score = 55.8 bits (133), Expect = 3e-08
Identities = 35/123 (28%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 1 MEGHVYWTD-------DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT 53
+ G +YWTD D V I +A++DG Q + +K+ P+ + +++ +LYW
Sbjct: 655 VNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDA 714
Query: 54 GTEHIEVTCLNSTSHKILVS-EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
+HIE LN T KI+ S +++ P ++ H +W D+ N I + +L E+
Sbjct: 715 YYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG--NYVFWTDY-MNGSIFQLDLITSEV 771
Query: 113 RVL 115
+L
Sbjct: 772 TLL 774
Score = 50.1 bits (118), Expect = 2e-06
Identities = 44/180 (24%), Positives = 71/180 (39%), Gaps = 29/180 (16%)
Query: 3 GHVYWTDDEV---------------WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARS 47
G++YWTD ++I L+G L+ +P IAVN
Sbjct: 3981 GNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4040
Query: 48 LYWTHTGT-EHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRAN 106
+YWT G HIE ++ T +ILV +++ P +A+ YW D+ E I
Sbjct: 4041 MYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF-ELSIIGSVL 4099
Query: 107 LDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIE------------AISVDETK 154
D V V++ G + +D+ E +Y K A+++D+TK
Sbjct: 4100 YDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTK 4159
Score = 47.4 bits (111), Expect = 1e-05
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 74 EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
E++ PRA+ H E Y+ D + I R +D E ++ L G+A+D
Sbjct: 553 ENLVNPRALDFHAETNYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGN 611
Query: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSI 186
LYW G KT + + R+TLL+ ++ H + + ++YWT W+ I
Sbjct: 612 NLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEI 669
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 12/118 (10%)
Query: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQ--------TLL 159
D E R ++ ++G GLA LYW + T I +VD+T+ T+
Sbjct: 2256 DNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMS 2315
Query: 160 KDKLPHIFRFTLLGDFIYWTAW--QHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVD 215
+D PH+ + ++WT W QH SI R N V++ D++ + +D
Sbjct: 2316 EDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVS--TDILTPNGLTID 2371
Score = 40.0 bits (92), Expect = 0.002
Identities = 22/76 (28%), Positives = 42/76 (55%), Gaps = 1/76 (1%)
Query: 21 DGSGAQTLINTKINDPDDIAVNWVARSLYWTHTG-TEHIEVTCLNSTSHKILVSEDMDEP 79
+GS TLI+ ++++P IAV+ +A L++T G +E ++ + ++ ++P
Sbjct: 313 NGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQP 372
Query: 80 RAIALHPEMGLTYWID 95
A+AL L YW+D
Sbjct: 373 AALALDLVNKLVYWVD 388
Score = 38.5 bits (88), Expect = 0.006
Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%)
Query: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTA 180
P L + +Y+ D + I +D T+R+T+LKD L ++ + +G+ +YWT
Sbjct: 558 PRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTN 617
Query: 181 WQHH---SIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
H ++ R+ K +R +++ ++ + + VD V G
Sbjct: 618 DGHRKTINVARLEKASQSRKTLLE--GEMSHPRGIVVDPVNG 657
Score = 33.9 bits (76), Expect = 0.14
Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 8/123 (6%)
Query: 3 GHVYWTDDEVW--AIRRAYLDGSGAQTLINTKIND--PDDIAVNWVARSLYWTHTGTEHI 58
G ++WTD + I A + G+G +T+ P+ + V+ + + WT ++ I
Sbjct: 1390 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAI 1449
Query: 59 EVTCLNSTSHKILVS--EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLV 116
+ T+ ++ E + P A++L+ YW DW N K Q + V+
Sbjct: 1450 YSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE--VYWTDWRTNTLSKANKWTGQNVSVIQ 1507
Query: 117 NAS 119
S
Sbjct: 1508 KTS 1510
Score = 30.8 bits (68), Expect = 1.2
Identities = 15/59 (25%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 3 GHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
G +++TD V + R +DG +I++K P +A++ V + +YW +++ V
Sbjct: 338 GKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGV 396
Score = 28.5 bits (62), Expect = 5.8
Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 2/94 (2%)
Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQ 182
G+ + +YW D +KI D+T ++ ++ + L + + + IYWT
Sbjct: 1914 GIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHG 1973
Query: 183 HHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDK 216
+ I+ + R VII Q D AV+ +K
Sbjct: 1974 FNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEK 2007
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 144 bits (362), Expect = 1e-34
Identities = 75/252 (29%), Positives = 123/252 (48%), Gaps = 10/252 (3%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+E +YW D + I R +L+ + +T+IN ++ + +AV+WV+R LYW + + V
Sbjct: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296
Query: 61 TCLNSTSHKILVSEDMD--------EPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
+ LN ++L +D PR +ALHP+ G YW DWG I R +D
Sbjct: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356
Query: 113 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
V+++ L WPNG+ +D LYW DA IE ++ R T+ LPH F T+
Sbjct: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416
Query: 173 GDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVN-VDKVVGTNPHADRNGGA 230
D IYWT W ++++ +K +NR +++ + + + + +NP NGG
Sbjct: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGC 3476
Query: 231 ATCASSRPTQPG 242
+ +P G
Sbjct: 3477 SHLCLIKPGGKG 3488
Score = 132 bits (331), Expect = 4e-31
Identities = 67/187 (35%), Positives = 109/187 (58%), Gaps = 10/187 (5%)
Query: 14 AIRRAYLDG--SGAQTLINTK------INDPDDIAVNWVARSLYWTHTGTEHIEVTCLNS 65
AI+RAY+ SG L+ + PD IAV+WV R +YW+ + IEV L+
Sbjct: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173
Query: 66 TSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNG 125
K L+S D+D+P AIA++P++GL +W DWG+ P+I+ A ++ ++ +LV LGWP G
Sbjct: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233
Query: 126 LALD-LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
L++D L ++YW D K D IE I D T R+ + K+ + + + + D +YW + +
Sbjct: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKG 4292
Query: 185 SIKRVHK 191
+ + +K
Sbjct: 4293 EVWKQNK 4299
Score = 122 bits (307), Expect = 2e-28
Identities = 70/239 (29%), Positives = 128/239 (53%), Gaps = 15/239 (6%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
++++D I + +DG+G + L ++ + + +A +W++++LYWT + + I V L
Sbjct: 755 IFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLA 814
Query: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
+ + +V + ++ PR++ +HP G ++ DW +I RA D L ++N +LGWPN
Sbjct: 815 DKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPN 873
Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTLLGDFIYWTAWQH 183
GLA+D +LYW DA DKIE + D R+ L +++ H F + G+ +++T W+
Sbjct: 874 GLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRL 933
Query: 184 HSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQP 241
+I RV K VI + ++ LK+ +V+ G+N A ++PT P
Sbjct: 934 GAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSN------------ACNQPTHP 980
Score = 120 bits (301), Expect = 1e-27
Identities = 66/221 (29%), Positives = 118/221 (53%), Gaps = 5/221 (2%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+ G ++W+D A+ +G+ + + ++ I + IA++WV R+LYWT E IEV
Sbjct: 1476 ISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEV 1535
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMG--LTYWIDWGENPEIKRANLDRQELRVLVNA 118
+ ++ + +L+S+++ PR +AL P M L +W DWG +P I+RA++D V+V
Sbjct: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595
Query: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDK-LPHIFRFTLLGDFI 176
+ WP GL +D LY+ D+ D ++ + +RQ + D + H + TL D +
Sbjct: 1596 KIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSV 1655
Query: 177 YWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNVDK 216
YWT + R +K N+ V++ + +G+ AV+ K
Sbjct: 1656 YWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696
Score = 120 bits (300), Expect = 1e-27
Identities = 68/243 (27%), Positives = 123/243 (50%), Gaps = 8/243 (3%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
V+WTD + ++G Q ++N + P+++AV+WV +Y T I++ L+
Sbjct: 438 VFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLD 497
Query: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDW---GENPEIKRANLDRQELRVLVNASLG 121
+ L++E++ PR IA+ P +G ++ DW P+++RA +D + LV LG
Sbjct: 498 GSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLG 557
Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWT 179
WP G+ LD+ ++YW D++ D IE ++ D +R+T++ +PH F +L +++T
Sbjct: 558 WPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFT 617
Query: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAV-NVDKVVGTNPHADRNGGA-ATCASS 236
W ++ + +K + N V G+ ++ + TNP D NGG C S
Sbjct: 618 DWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLS 677
Query: 237 RPT 239
T
Sbjct: 678 HRT 680
Score = 101 bits (251), Expect = 7e-22
Identities = 66/220 (30%), Positives = 104/220 (47%), Gaps = 6/220 (2%)
Query: 22 GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRA 81
G T+I + I D IA +W+ R +Y++ + I + ++ ++ + +PRA
Sbjct: 2454 GIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRA 2511
Query: 82 IALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAK 141
I L P G YW DW + +I+RA L +VN+SL P+GL LD +E LYW DA
Sbjct: 2512 IVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDAS 2571
Query: 142 TDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVII- 200
+IE ++ R+ ++ + H F TL G +IYWT I R +K + + +
Sbjct: 2572 LQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMT 2630
Query: 201 -DQLPDLMGLK-AVNVDKVVGTNPHADRNGGAATCASSRP 238
+ L G+ V K NP NGG + + P
Sbjct: 2631 TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGP 2670
Score = 99.4 bits (246), Expect = 3e-21
Identities = 79/263 (30%), Positives = 119/263 (45%), Gaps = 22/263 (8%)
Query: 3 GHVYWTDDEVW-----AIRRAYLDGSGAQTLINTKI--NDPDDIAVNWVARSLYWTHTGT 55
G +YW D AIRR DGS ++ I N IAV+WVA +LY+T+
Sbjct: 2107 GFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFV 2166
Query: 56 EH--IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELR 113
IEV +N+T ++L+ +D PR I + P+ +W D+G+ P+I+R+ LD
Sbjct: 2167 SETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRT 2226
Query: 114 VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDKLPHIFRFTLL 172
VLV+ + P GLA+D +G +YW D D I I ++ E + P + T+
Sbjct: 2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVF 2286
Query: 173 GDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNV-DK--------VVGTNPH 223
+ I W I + K N + ++ L+ V + DK V NP
Sbjct: 2287 ENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPC 2346
Query: 224 ADRNGGAATCASSRPTQPGLAAP 246
+ NGG C+ PGL P
Sbjct: 2347 LENNGG---CSHLCFALPGLHTP 2366
Score = 94.7 bits (234), Expect = 7e-20
Identities = 68/222 (30%), Positives = 112/222 (50%), Gaps = 15/222 (6%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPD-DIAVNWVARSLYWTHTGTEHIEV 60
E ++YW ++ I R DG+ + + P ++A++W++R+LY T+ T+ IEV
Sbjct: 1789 EQYIYWVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEV 1847
Query: 61 TCLNSTSH--KILVSED-----MDEPRAIALHPEMGLTYWIDWGENP----EIKRANLDR 109
L+ K L++ D + P I + P G YW D G + +I AN+D
Sbjct: 1848 LTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDG 1907
Query: 110 QELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRF 169
++ L +L + LD++E KLYW IE +VD T R +L +L H +
Sbjct: 1908 TSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRM-ILVHQLSHPWGI 1966
Query: 170 TLLGDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLK 210
+ F+Y+T Q+ I+RV K AN+ V+ D +P+L GL+
Sbjct: 1967 AVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQ 2008
Score = 66.6 bits (161), Expect = 2e-11
Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 6/136 (4%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
H+YW+D + I A LDG + LI+T ++ P IAVN ++WT G E IE
Sbjct: 4155 HIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAW 4214
Query: 63 LNSTSHKILVSEDMDEPRAIAL-HPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
+N ILV ED+ P +++ + YW D+ E+ I+ D + RV+ ++
Sbjct: 4215 MNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED-VIETIKYDGTDRRVIAKEAM- 4272
Query: 122 WPNGLALDLQEGKLYW 137
N +LD+ E +LYW
Sbjct: 4273 --NPYSLDIFEDQLYW 4286
Score = 40.8 bits (94), Expect = 0.001
Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 4/95 (4%)
Query: 2 EGHVYWTDDEVWA-IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+G++YW D + A I RA L G+ ++N+ + P + +++ LYW + IE
Sbjct: 2518 QGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIER 2577
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWID 95
+ L +++V+ + A L YW D
Sbjct: 2578 STLTGVDREVIVNAAV---HAFGLTLYGQYIYWTD 2609
Score = 33.5 bits (75), Expect = 0.18
Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 121 GWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP 164
G N +ALD E +LYW D + IE + +++T ++T++ +LP
Sbjct: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLP 3270
Score = 27.7 bits (60), Expect = 9.9
Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 6/53 (11%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTL-INTKINDPDDI-----AVNWVARSL 48
+G+VYW DD + I R ++G ++ + ++ P I ++ WV R+L
Sbjct: 2245 DGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNL 2297
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 135 bits (341), Expect = 3e-32
Identities = 76/239 (31%), Positives = 125/239 (52%), Gaps = 3/239 (1%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+E +Y+ + I RA +DGS + LI ++ P+ +AV+W+ R YWT G I
Sbjct: 522 VENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGR 581
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
+ LN KI+ E++ +PR IA+HP +W D G NP I+ ++L V+ ++ L
Sbjct: 582 SDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDL 641
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
WP+G+ +D KLYW DAK IE ++D +KR+ L ++ + H F + D+++++
Sbjct: 642 IWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD 701
Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVV--GTNPHADRNGGAATCASSR 237
W S+ RV+K + +D + Q L V V + G +P +NGG R
Sbjct: 702 WAMPSVMRVNK-RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKR 759
Score = 57.8 bits (138), Expect = 9e-09
Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 8/189 (4%)
Query: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
E +YW D E ++R +L+GS + + N + N +A+NW+ + W++ I VT
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKN-VSGMAINWINEEVIWSNQQEGIITVT 143
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
+ + IL+S + P +A+ P +W + RA+LD ++ L+ S
Sbjct: 144 DMKGNNSHILLSA-LKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALLETS-E 200
Query: 122 WPNGLALDLQEGKLYW----GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
++LD+ + +L+W + I + D ++F +L GD I+
Sbjct: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIF 260
Query: 178 WTAWQHHSI 186
++ W+ +I
Sbjct: 261 YSTWKMKTI 269
Score = 28.1 bits (61), Expect = 7.6
Identities = 13/56 (23%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE 56
+E ++W+ + ++ RA LDG G + L+ T ++++ + + L+W E
Sbjct: 168 VERFIFWSSEVAGSLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNRE 222
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 132 bits (333), Expect = 2e-31
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
Query: 179 TAWQHHSI 186
T ++ +I
Sbjct: 644 TDLENEAI 651
Score = 63.9 bits (154), Expect = 1e-10
Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
H+YWTD I A +DG +TL + +++P IAV+ + +YW+ G + IE +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
LN + LVS++++ P I L YW+D + ++ + + L++++ L
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 628
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
P G+A + E K++W D + + I
Sbjct: 629 SHPFGIA--VFEDKVFWTDLENEAI 651
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 132 bits (333), Expect = 2e-31
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 335 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 394
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 395 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 454
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 455 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 514
Query: 179 TAWQHHSI 186
T ++ +I
Sbjct: 515 TDLENEAI 522
Score = 63.9 bits (154), Expect = 1e-10
Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
H+YWTD I A +DG +TL + +++P IAV+ + +YW+ G + IE +
Sbjct: 381 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 440
Query: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
LN + LVS++++ P I L YW+D + ++ + + L++++ L
Sbjct: 441 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 499
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
P G+A + E K++W D + + I
Sbjct: 500 SHPFGIA--VFEDKVFWTDLENEAI 522
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 132 bits (333), Expect = 2e-31
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 294 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 353
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 354 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 413
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 414 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 473
Query: 179 TAWQHHSI 186
T ++ +I
Sbjct: 474 TDLENEAI 481
Score = 63.9 bits (154), Expect = 1e-10
Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
H+YWTD I A +DG +TL + +++P IAV+ + +YW+ G + IE +
Sbjct: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 399
Query: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
LN + LVS++++ P I L YW+D + ++ + + L++++ L
Sbjct: 400 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 458
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
P G+A + E K++W D + + I
Sbjct: 459 SHPFGIA--VFEDKVFWTDLENEAI 481
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 132 bits (333), Expect = 2e-31
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
Query: 179 TAWQHHSI 186
T ++ +I
Sbjct: 644 TDLENEAI 651
Score = 63.9 bits (154), Expect = 1e-10
Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
H+YWTD I A +DG +TL + +++P IAV+ + +YW+ G + IE +
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
LN + LVS++++ P I L YW+D + ++ + + L++++ L
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 628
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
P G+A + E K++W D + + I
Sbjct: 629 SHPFGIA--VFEDKVFWTDLENEAI 651
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 127 bits (320), Expect = 7e-30
Identities = 73/215 (33%), Positives = 116/215 (53%), Gaps = 5/215 (2%)
Query: 2 EGHVYWTDDEVWAIRRAYLD-GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
E VYWTD I RA L+ G+ +T++N+ + P+ +A++ + R++YWT + + IE
Sbjct: 1153 ERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIES 1212
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNAS 119
L+ + K+L D+ PRAIA+ P G YW DW E P+I+ ++LD + R+L+N
Sbjct: 1213 ALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1272
Query: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
+G PNGL D L W DA T K+E D T R+ ++++ L + F D Y T
Sbjct: 1273 IGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVSYADHFYHT 1331
Query: 180 AWQHHSIKRV--HKVKANRDVIIDQLPDLMGLKAV 212
W+ + V H + + + +Q L G+ AV
Sbjct: 1332 DWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 126 bits (316), Expect = 2e-29
Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)
Query: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
++W D AI A +D G + + +P IAV+WV +++YWT ++ I V L
Sbjct: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
Query: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
+ T K L + D+ EP +IA+ P G YW DWGE +I++A ++ + R LV A + WP
Sbjct: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181
NG+ LDL + +LYW D+K + ++ ++ R+ +LK + L H T+ D +YW
Sbjct: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
Query: 182 QHHSIKRVHK 191
++ ++ +K
Sbjct: 663 ENEAVYGANK 672
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 126 bits (316), Expect = 2e-29
Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)
Query: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
++W D AI A +D G + + +P IAV+WV +++YWT ++ I V L
Sbjct: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
Query: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
+ T K L + D+ EP +IA+ P G YW DWGE +I++A ++ + R LV A + WP
Sbjct: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181
NG+ LDL + +LYW D+K + ++ ++ R+ +LK + L H T+ D +YW
Sbjct: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
Query: 182 QHHSIKRVHK 191
++ ++ +K
Sbjct: 663 ENEAVYGANK 672
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 125 bits (314), Expect = 4e-29
Identities = 64/181 (35%), Positives = 97/181 (53%), Gaps = 6/181 (3%)
Query: 5 VYWTDDEVWAIRRAYLDG----SGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
+YW+D I LD S T+I+ I PD +AV+W+ ++YWT + + V
Sbjct: 441 IYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSV 500
Query: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
K L E+ +PRAI + P G YW DWG +IK+ L+ ++ LV ++
Sbjct: 501 ADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI 560
Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKD--KLPHIFRFTLLGDFIYW 178
WPNG+ LDL G+LYW D+K I +I V+ R+T+L+D +L H F + D ++W
Sbjct: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
Query: 179 T 179
T
Sbjct: 621 T 621
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 122 bits (306), Expect = 3e-28
Identities = 73/221 (33%), Positives = 120/221 (54%), Gaps = 7/221 (3%)
Query: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
+YW+D + I+R L+GS G + +IN+ + + +A +++ LYW G + IEV
Sbjct: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
Query: 64 NSTSHKILVSED-MDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLG 121
+ +V+ +D PRA+ L P+ G+ +W DWG+ P I R+N+D LV+ +
Sbjct: 862 DGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK 921
Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
WPNG+++D Q +YW DA + IE I+ +R +L D LPH + + + IYW W
Sbjct: 922 WPNGISVDDQ--WIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDW 978
Query: 182 QHHSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTN 221
SI R K ++ +++ +QL LM +K K G+N
Sbjct: 979 SQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSN 1019
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 120 bits (302), Expect = 9e-28
Identities = 64/183 (34%), Positives = 99/183 (54%), Gaps = 2/183 (1%)
Query: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
VYWTD +I RA L G T+I + P+ IAV+ + R+++WT + + IEV L+
Sbjct: 992 VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD 1051
Query: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNASLGWP 123
T ++L D+ PR I G YW DW +NP+I+ + +D R+LV LG P
Sbjct: 1052 GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLP 1111
Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
NGL D +L W DA T++ E ++ + R+ L + L + F T G +Y+T W+
Sbjct: 1112 NGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKM 1170
Query: 184 HSI 186
+S+
Sbjct: 1171 NSV 1173
Score = 56.6 bits (135), Expect = 2e-08
Identities = 29/98 (29%), Positives = 50/98 (51%), Gaps = 2/98 (2%)
Query: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH--IEVT 61
+++WTD + I A LDG+ + L T + +P I + V +LYWT ++ IE +
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
Query: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN 99
++ T+ +ILV +D+ P + W+D G N
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 1131
Score = 29.3 bits (64), Expect = 3.4
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 4/105 (3%)
Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAWQ 182
GLA D + +YW D I S+ + T+++ L P LG I+WT
Sbjct: 982 GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSN 1041
Query: 183 HHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRN 227
I+ R V+ + DL+ + + D V G D N
Sbjct: 1042 LDRIEVAKLDGTQRRVLFE--TDLVNPRGIVTDSVRGNLYWTDWN 1084
>gi|226498382 tetratricopeptide repeat domain 5 [Homo sapiens]
Length = 440
Score = 30.4 bits (67), Expect = 1.5
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 7/105 (6%)
Query: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTC 62
G VYW +V A + SGA T K++ + ++ V R L T T EH
Sbjct: 110 GEVYWKKGDVAAAHTCF---SGALTHCRNKVSLQN---LSMVLRQLR-TDTEDEHSHHVM 162
Query: 63 LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
+ K+ V D+ + R+ + L+ + G+NP+I + L
Sbjct: 163 DSVRQAKLAVQMDVHDGRSWYILGNSYLSLYFSTGQNPKISQQAL 207
>gi|112807226 hypothetical protein LOC91748 [Homo sapiens]
Length = 1045
Score = 29.3 bits (64), Expect = 3.4
Identities = 12/28 (42%), Positives = 13/28 (46%)
Query: 225 DRNGGAATCASSRPTQPGLAAPSRAWNC 252
+R GG SS QPG P WNC
Sbjct: 109 ERGGGGGVSDSSWQQQPGQPPPHSTWNC 136
>gi|6005705 G protein-coupled receptor 182 [Homo sapiens]
Length = 404
Score = 29.3 bits (64), Expect = 3.4
Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 2/42 (4%)
Query: 51 THTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTY 92
T GT +C ST H I++++ +P A A HPE L++
Sbjct: 344 TKAGTCASSSSC--STQHSIIITKGDSQPAAAAPHPEPSLSF 383
>gi|44890062 hypothetical protein LOC91748 [Homo sapiens]
Length = 1045
Score = 29.3 bits (64), Expect = 3.4
Identities = 12/28 (42%), Positives = 13/28 (46%)
Query: 225 DRNGGAATCASSRPTQPGLAAPSRAWNC 252
+R GG SS QPG P WNC
Sbjct: 109 ERGGGGGVSDSSWQQQPGQPPPHSTWNC 136
>gi|33589848 transferrin receptor 2 [Homo sapiens]
Length = 801
Score = 28.9 bits (63), Expect = 4.5
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 3/39 (7%)
Query: 128 LDLQEGKLYWGDAKTDKIEAIS---VDETKRQTLLKDKL 163
LD +G+LYW D + ++ + +++T RQT L++++
Sbjct: 128 LDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERV 166
>gi|169208029 PREDICTED: hypothetical protein [Homo sapiens]
Length = 134
Score = 28.1 bits (61), Expect = 7.6
Identities = 12/32 (37%), Positives = 16/32 (50%)
Query: 220 TNPHADRNGGAATCASSRPTQPGLAAPSRAWN 251
+ PHA + A+ R T PG PS AW+
Sbjct: 66 STPHAPLSASGEHPATPRHTHPGYIPPSHAWS 97
>gi|239755684 PREDICTED: hypothetical protein [Homo sapiens]
Length = 415
Score = 27.7 bits (60), Expect = 9.9
Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 17/101 (16%)
Query: 20 LDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEP 79
+D G+Q IN K+ND + + + + I + + VS ++P
Sbjct: 91 VDNHGSQQDINHKVNDTEQL------EDAHGNEFALKLIGHATVGGFQTRSAVSSSAEQP 144
Query: 80 RAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
+ ++P+ P+ +R NL+R L VL N L
Sbjct: 145 PS-NMNPQ----------RQPDARRKNLERNSLSVLTNRDL 174
>gi|239750147 PREDICTED: hypothetical protein [Homo sapiens]
Length = 415
Score = 27.7 bits (60), Expect = 9.9
Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 17/101 (16%)
Query: 20 LDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEP 79
+D G+Q IN K+ND + + + + I + + VS ++P
Sbjct: 91 VDNHGSQQDINHKVNDTEQL------EDAHGNEFALKLIGHATVGGFQTRSAVSSSAEQP 144
Query: 80 RAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
+ ++P+ P+ +R NL+R L VL N L
Sbjct: 145 PS-NMNPQ----------RQPDARRKNLERNSLSVLTNRDL 174
>gi|239744457 PREDICTED: hypothetical protein [Homo sapiens]
Length = 351
Score = 27.7 bits (60), Expect = 9.9
Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 17/101 (16%)
Query: 20 LDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEP 79
+D G+Q IN K+ND + + + + I + + VS ++P
Sbjct: 27 VDNHGSQQDINHKVNDTEQL------EDAHGNEFALKLIGHATVGGFQTRSAVSSSAEQP 80
Query: 80 RAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
+ ++P+ P+ +R NL+R L VL N L
Sbjct: 81 PS-NMNPQ----------RQPDARRKNLERNSLSVLTNRDL 110
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,100,017
Number of Sequences: 37866
Number of extensions: 418084
Number of successful extensions: 1255
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 865
Number of HSP's gapped (non-prelim): 120
length of query: 252
length of database: 18,247,518
effective HSP length: 100
effective length of query: 152
effective length of database: 14,460,918
effective search space: 2198059536
effective search space used: 2198059536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.