Guide to the Human Genome
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Search of human proteins with 32698824

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32698824 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
         (252 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32698824 low density lipoprotein receptor-related protein 5-l...   530   e-151
gi|209447022 low density lipoprotein receptor-related protein 5-...   530   e-151
gi|119709832 low density lipoprotein receptor-related protein 5 ...   399   e-111
gi|148727288 low density lipoprotein receptor-related protein 6 ...   329   2e-90
gi|157384998 low density lipoprotein receptor-related protein 4 ...   203   1e-52
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...   176   2e-44
gi|93102379 low density lipoprotein-related protein 1B precursor...   161   6e-40
gi|126012573 low density lipoprotein-related protein 2 [Homo sap...   144   1e-34
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...   135   3e-32
gi|61744471 low density lipoprotein receptor-related protein 8 i...   132   2e-31
gi|61744467 low density lipoprotein receptor-related protein 8 i...   132   2e-31
gi|66082554 low density lipoprotein receptor-related protein 8 i...   132   2e-31
gi|65301119 low density lipoprotein receptor-related protein 8 i...   132   2e-31
gi|144953895 nidogen 2 precursor [Homo sapiens]                       127   7e-30
gi|65301164 very low density lipoprotein receptor isoform b [Hom...   126   2e-29
gi|65301167 very low density lipoprotein receptor isoform a [Hom...   126   2e-29
gi|4504975 low density lipoprotein receptor precursor [Homo sapi...   125   4e-29
gi|4507157 sortilin-related receptor containing LDLR class A rep...   122   3e-28
gi|115298674 nidogen 1 precursor [Homo sapiens]                       120   9e-28
gi|226498382 tetratricopeptide repeat domain 5 [Homo sapiens]          30   1.5  
gi|112807226 hypothetical protein LOC91748 [Homo sapiens]              29   3.4  
gi|6005705 G protein-coupled receptor 182 [Homo sapiens]               29   3.4  
gi|44890062 hypothetical protein LOC91748 [Homo sapiens]               29   3.4  
gi|33589848 transferrin receptor 2 [Homo sapiens]                      29   4.5  
gi|169208029 PREDICTED: hypothetical protein [Homo sapiens]            28   7.6  
gi|239755684 PREDICTED: hypothetical protein [Homo sapiens]            28   9.9  
gi|239750147 PREDICTED: hypothetical protein [Homo sapiens]            28   9.9  
gi|239744457 PREDICTED: hypothetical protein [Homo sapiens]            28   9.9  

>gi|32698824 low density lipoprotein receptor-related protein 5-like
           [Homo sapiens]
          Length = 252

 Score =  530 bits (1366), Expect = e-151
 Identities = 252/252 (100%), Positives = 252/252 (100%)

Query: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV
Sbjct: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
           TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL
Sbjct: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
           GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180

Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
           WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240

Query: 241 PGLAAPSRAWNC 252
           PGLAAPSRAWNC
Sbjct: 241 PGLAAPSRAWNC 252


>gi|209447022 low density lipoprotein receptor-related protein
           5-like [Homo sapiens]
          Length = 252

 Score =  530 bits (1366), Expect = e-151
 Identities = 252/252 (100%), Positives = 252/252 (100%)

Query: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV
Sbjct: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
           TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL
Sbjct: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
           GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180

Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
           WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240

Query: 241 PGLAAPSRAWNC 252
           PGLAAPSRAWNC
Sbjct: 241 PGLAAPSRAWNC 252


>gi|119709832 low density lipoprotein receptor-related protein 5
           [Homo sapiens]
          Length = 1615

 Score =  399 bits (1024), Expect = e-111
 Identities = 193/231 (83%), Positives = 209/231 (90%)

Query: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +EG+VYWTDDEV AIRRAYLDGSGAQTL+NT+INDPD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 383 LEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEV 442

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
           T LN TS KILVSED+DEPRAIALHP MGL YW DWGENP+I+ ANLD QE RVLVNASL
Sbjct: 443 TRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASL 502

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
           GWPNGLALDLQEGKLYWGDAKTDKIE I+VD TKR+TLL+DKLPHIF FTLLGDFIYWT 
Sbjct: 503 GWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 562

Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
           WQ  SI+RVHKVKA+RDVIIDQLPDLMGLKAVNV KVVGTNP ADRNGG +
Sbjct: 563 WQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCS 613



 Score =  191 bits (484), Expect = 7e-49
 Identities = 97/244 (39%), Positives = 144/244 (59%), Gaps = 4/244 (1%)

Query: 2   EGHVYWTDDEVWAIRRAYLDGSGA--QTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
           +G VYWTD    AI++ YL+ +GA  Q ++ + +  PD +A +WV + LYWT + T  IE
Sbjct: 74  KGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIE 133

Query: 60  VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
           V  LN TS K+L  +D+D+PRAIAL P  G  YW DWGE P I+RA +D    +++V++ 
Sbjct: 134 VANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSD 193

Query: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
           + WPNGL +DL+E KLYW DAK   I   ++D + RQ +++  L H F  TL GD +YWT
Sbjct: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253

Query: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADR-NGGAATCASSR 237
            WQ  SI   +K     R  I+  L   M ++ ++ ++    +   +  NGG +      
Sbjct: 254 DWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLS 313

Query: 238 PTQP 241
           P++P
Sbjct: 314 PSEP 317



 Score =  161 bits (407), Expect = 6e-40
 Identities = 83/226 (36%), Positives = 126/226 (55%), Gaps = 3/226 (1%)

Query: 4   HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
           H+YWTD  +  I RA+++GS  + ++   ++ P+ +AV+W+ ++LYW  TGT  IEV  L
Sbjct: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747

Query: 64  NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
           +    ++LV  D+D PR++AL P  G  YW +WG  P I RA +D      LV+  +G  
Sbjct: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRA 806

Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
           N L +D  + +LYW D  T+ IE+ ++   +R  ++ D LPH F  T   D+IYWT W  
Sbjct: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNL 865

Query: 184 HSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228
           HSI+R  K    NR +I   L  +M +   +  +  G N     NG
Sbjct: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNG 911



 Score = 99.0 bits (245), Expect = 4e-21
 Identities = 76/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)

Query: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND-------PDDIAVNWVARSLYWTHT 53
            ++  +YW D     I+RA  DG+  Q  + T ++        P D++++  +R+L+WT  
Sbjct: 987  LDKFIYWVDGRQ-NIKRAKDDGT--QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCE 1043

Query: 54   GTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP-EIKRANLDRQEL 112
             T  I V  L+  +  +++  D D+PRAI ++ E G  Y+ +  +   +I+RA LD  E 
Sbjct: 1044 ATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTER 1103

Query: 113  RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
             VL    L  P  L +D   GKL+W DA   +IE+  +    R TL    +      T+L
Sbjct: 1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL 1163

Query: 173  GDFIYWTAWQHHSIKRVHKVKAN-RDVIIDQLPDLMGLKAVNVDKV--VGTNPHADRNGG 229
            G  +YW   Q   I+RV K   + R  I  ++  L G+ AV    +     +P A  NGG
Sbjct: 1164 GKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGG 1223

Query: 230  AA-TCASSRPTQPGLAAP 246
             +  C +     P  + P
Sbjct: 1224 CSHICIAKGDGTPRCSCP 1241



 Score = 34.7 bits (78), Expect = 0.081
 Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 21/229 (9%)

Query: 5   VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
           +YWTD +  +I        G +  I + +  P DI V    R  ++ HT  E     C  
Sbjct: 250 LYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFF-HTRCEEDNGGC-- 306

Query: 65  STSHKILVSEDMDE-----PRAIALHP-----EMGLTYWIDWGENPEIKRANLDRQELRV 114
             SH  L+S          P  + L       + G    +      +++R +LD  +   
Sbjct: 307 --SHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTD 364

Query: 115 LVNASLGWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFT 170
           +V       + +A+D    EG +YW D +   I    +D +  QTL+  ++  P      
Sbjct: 365 IVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVD 424

Query: 171 LLGDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
            +   +YWT      I+       +R +++ +  DL   +A+ +  V+G
Sbjct: 425 WVARNLYWTDTGTDRIEVTRLNGTSRKILVSE--DLDEPRAIALHPVMG 471


>gi|148727288 low density lipoprotein receptor-related protein 6
           [Homo sapiens]
          Length = 1613

 Score =  329 bits (843), Expect = 2e-90
 Identities = 154/246 (62%), Positives = 190/246 (77%)

Query: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +EG++YWTDDEV AIRR+++DGSG+Q ++  +I  PD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
           T LN T  KIL+SED++EPRAI L P +G  YW DWGE P+I+RA LD  +  VLVN SL
Sbjct: 430 TRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSL 489

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
           GWPNGLALD  EGK+YWGDAKTDKIE ++ D T R+ L++DK+PHIF FTLLGD++YWT 
Sbjct: 490 GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 549

Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
           WQ  SI+RVHK  A R+VIIDQLPDLMGLKA NV +V+G+NP A+ NGG +     RP  
Sbjct: 550 WQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQG 609

Query: 241 PGLAAP 246
              A P
Sbjct: 610 LRCACP 615



 Score =  177 bits (450), Expect = 6e-45
 Identities = 92/243 (37%), Positives = 137/243 (56%), Gaps = 5/243 (2%)

Query: 3   GHVYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
           G +YW+D    AI+R   + +   Q ++ + +  PD +A +W+   LYWT + T  IEV+
Sbjct: 63  GLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVS 122

Query: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
            L+ +  K+L  +++D+PRAIAL P  G  YW DWGE P+I+RA +D     +++N+ + 
Sbjct: 123 NLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIY 182

Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
           WPNGL LD +E KLYW DAK + I   ++D T RQ ++K  LPH F  TL  D +YWT W
Sbjct: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242

Query: 182 QHHSIKRVHKVKAN--RDVIIDQLPDLMGLKAVNVDKVV-GTNPHADRNGGAATCASSRP 238
             HSI   +K      R++  D +   M + A +  +    TNP    NGG +      P
Sbjct: 243 STHSILACNKYTGEGLREIHSD-IFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP 301

Query: 239 TQP 241
            +P
Sbjct: 302 VKP 304



 Score =  166 bits (421), Expect = 1e-41
 Identities = 85/228 (37%), Positives = 132/228 (57%), Gaps = 3/228 (1%)

Query: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
           +  +YWTD  +  I RA+++GS  + ++   ++ P+ +AV+W+ ++LYW  TGT  IEV+
Sbjct: 673 DNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVS 732

Query: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
            L+    ++LV +D+D PRA+AL P  G  YW +WG  P+I RA +D  E   LV  ++G
Sbjct: 733 KLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVG 791

Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
             NGL +D  + +LYW D  T+ IE+ ++    R+ ++ D LPH F  T   D+IYWT W
Sbjct: 792 RANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNRE-VIADDLPHPFGLTQYQDYIYWTDW 850

Query: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228
              SI+R +K    NR +I   L  +M +   +  +  G N  A  NG
Sbjct: 851 SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNG 898



 Score =  109 bits (273), Expect = 2e-24
 Identities = 71/242 (29%), Positives = 122/242 (50%), Gaps = 12/242 (4%)

Query: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND------PDDIAVNWVARSLYWTHTG 54
            ++  +YW D     IR+A  DGS   T++ + +        P D++++  +R +YWT   
Sbjct: 975  LDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA 1034

Query: 55   TEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELR 113
            T  I VT L+  S  +++  + D PRA+ ++PE G  Y+ +  E +P+I+RA LD  E  
Sbjct: 1035 TNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTERE 1094

Query: 114  VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLG 173
            VL  + L  P  LALD + GKL+W D+   +IE+  +    R  L    +      T+  
Sbjct: 1095 VLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE 1154

Query: 174  DFIYWTAWQHHSIKRV----HKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGG 229
            +++YW   Q   I+++     + +      I QL D+  +K +N+ +    +P A  NGG
Sbjct: 1155 NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQE-YRQHPCAQDNGG 1213

Query: 230  AA 231
             +
Sbjct: 1214 CS 1215



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 3/114 (2%)

Query: 70  ILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALD 129
           +L  ED+    AI   P  G  YW D  E   I+R+ +D    + +V A +  P+G+A+D
Sbjct: 353 VLQLEDIRHAIAIDYDPVEGYIYWTD-DEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411

Query: 130 LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAW 181
                LYW D  TD+IE   ++ T R+ L+ + L  P       +  ++YWT W
Sbjct: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW 465



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 5/146 (3%)

Query: 60  VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQE-LRVLVNA 118
           V   N   +  +V   +++  A+      GL YW D  E   IKR   ++ E ++ +V +
Sbjct: 34  VDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA-IKRTEFNKTESVQNVVVS 92

Query: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFI 176
            L  P+GLA D    KLYW D++T++IE  ++D + R+ L   +L  P          F+
Sbjct: 93  GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152

Query: 177 YWTAW-QHHSIKRVHKVKANRDVIID 201
           YWT W +   I+R     ++R +II+
Sbjct: 153 YWTDWGEVPKIERAGMDGSSRFIIIN 178



 Score = 33.9 bits (76), Expect = 0.14
 Identities = 53/271 (19%), Positives = 98/271 (36%), Gaps = 58/271 (21%)

Query: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
           E  +YW D ++  I ++ LDG+  Q ++   +  P   A+      LYWT   T H  + 
Sbjct: 193 EQKLYWADAKLNFIHKSNLDGTNRQAVVKGSL--PHPFALTLFEDILYWTDWST-HSILA 249

Query: 62  CLNSTSHKIL-VSEDMDEPRAI----------ALHP------------------------ 86
           C   T   +  +  D+  P  I          A +P                        
Sbjct: 250 CNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCA 309

Query: 87  --------------EMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQ- 131
                         + G T  +      +++R +LD  +   +V       + +A+D   
Sbjct: 310 CPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP 369

Query: 132 -EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSIKR 188
            EG +YW D +   I    +D +  Q ++  ++ H     +  +   +YWT      I+ 
Sbjct: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429

Query: 189 VHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
                  R ++I +  DL   +A+ +D +VG
Sbjct: 430 TRLNGTMRKILISE--DLEEPRAIVLDPMVG 458


>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
            sapiens]
          Length = 1905

 Score =  203 bits (517), Expect = 1e-52
 Identities = 102/247 (41%), Positives = 148/247 (59%), Gaps = 2/247 (0%)

Query: 2    EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
            EG VYW+D  +  I RA LDGS  + +I T +   D +AV+ + R +YWT TGT  IEV 
Sbjct: 1092 EGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVG 1151

Query: 62   CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
             L+ +  K+LV +++D PRAI L+ EMG  YW DWGEN +++R+ +D  +  VL+N +LG
Sbjct: 1152 NLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLG 1211

Query: 122  WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
            WPNGL +D    +L W DA T++IEA  ++   R TL+   + H +  TLL  +IYWT W
Sbjct: 1212 WPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYWTDW 1270

Query: 182  QHHSIKRVHKVKANRDVII-DQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
            Q  SI R  K   +  +++   LP LM ++AV+  + +G N    RNGG +     RP+ 
Sbjct: 1271 QTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG 1330

Query: 241  PGLAAPS 247
               A P+
Sbjct: 1331 FSCACPT 1337



 Score =  196 bits (497), Expect = 2e-50
 Identities = 101/247 (40%), Positives = 145/247 (58%), Gaps = 2/247 (0%)

Query: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
            ++G VY+TD  +  IRRA L+GS  +T+I   +   D +AV+WVAR+LYWT TG   IE 
Sbjct: 1395 VDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEA 1454

Query: 61   TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
            + L+ +  K+L++  +DEPRAIA+ P  G  +W DWG   +I+RANLD  E +VL+N  L
Sbjct: 1455 SRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDL 1514

Query: 121  GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
            GWPNGL LD    ++YW DA  D+IE+  ++   RQ L+   + H F  T    +IYWT 
Sbjct: 1515 GWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIYWTD 1573

Query: 181  WQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPT 239
            WQ  SI+RV K    N++ ++  +  LM +  V+  +  GTN     NGG      +R +
Sbjct: 1574 WQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARAS 1633

Query: 240  QPGLAAP 246
                A P
Sbjct: 1634 DFVCACP 1640



 Score =  190 bits (482), Expect = 1e-48
 Identities = 90/244 (36%), Positives = 140/244 (57%), Gaps = 1/244 (0%)

Query: 2    EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
            + HVYWTD     I RA  DG+G + +++T +  P  +A++WV   LYWT  GT+ IEV 
Sbjct: 784  DDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVA 843

Query: 62   CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
              + +   +L+ E++D PR I + P  G  YW DWG +P+I+RA +D    +V+++++L 
Sbjct: 844  NTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLT 903

Query: 122  WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
            WPNGLA+D    +LYW DA    IE   +D +KR+ L+  +LPH F  TL G+ IYWT W
Sbjct: 904  WPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDW 963

Query: 182  QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240
            Q  SI+   ++   +R+ + + L +LM +   +  +   + P A  NGG +      P  
Sbjct: 964  QTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNP 1023

Query: 241  PGLA 244
             G +
Sbjct: 1024 SGFS 1027



 Score =  172 bits (436), Expect = 2e-43
 Identities = 84/227 (37%), Positives = 132/227 (58%), Gaps = 2/227 (0%)

Query: 5   VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
           V+W+D  +  I RA L+GS  + +++T +  P  +AV+WV   LYWT +GT  IEV  L+
Sbjct: 482 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 541

Query: 65  STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
               K+L+ +++++PRAIALHP  G  YW DWG  P I+ +++D    R++ +  L WPN
Sbjct: 542 GAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPN 601

Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
           GL +D    ++YW DAK   IE  ++D + R+ ++   LPH F  T+  D +YWT W   
Sbjct: 602 GLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTK 661

Query: 185 SIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDK-VVGTNPHADRNGG 229
           SI   +K    N+++I ++L   M +  ++  +   G N   D NGG
Sbjct: 662 SINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGG 708



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 15/120 (12%)

Query: 1   MEGHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
           MEG +YWTD      I  + +DGSG + + +T +  P+ + +++  R +YW       IE
Sbjct: 564 MEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIE 623

Query: 60  VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDW------------GENPEIKRANL 107
              L+ +  K ++S+ +  P AI +  +    YW DW            G+N EI R  L
Sbjct: 624 RANLDGSHRKAVISQGLPHPFAITVFEDS--LYWTDWHTKSINSANKFTGKNQEIIRNKL 681



 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 47/224 (20%), Positives = 82/224 (36%), Gaps = 51/224 (22%)

Query: 5   VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
           +YW D +   I RA LDGS  + +I+  +  P   A+     SLYWT   T+ I      
Sbjct: 612 MYWVDAKHHVIERANLDGSHRKAVISQGL--PHPFAITVFEDSLYWTDWHTKSINSANKF 669

Query: 65  STSHKILVSEDMDEPRAI-ALHPE------------------------------------ 87
           +  ++ ++   +  P  I  LHP+                                    
Sbjct: 670 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFR 729

Query: 88  --------MGLTYWIDWGENPEIKRANLDRQELR--VLVNASLGWPNGLALDLQEGKLYW 137
                     L  ++ +    +I+R + D ++L   V+  A +     L  D ++  +YW
Sbjct: 730 KISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYW 789

Query: 138 GDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWT 179
            D  TD I     D T ++ ++   L  P       + + +YWT
Sbjct: 790 TDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWT 833



 Score = 36.6 bits (83), Expect = 0.021
 Identities = 45/227 (19%), Positives = 82/227 (36%), Gaps = 54/227 (23%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT------------- 51
            +YW D  +  I  A LDGS  + LI +++  P    +      +YWT             
Sbjct: 917  LYWADAGMKTIEFAGLDGSKRKVLIGSQL--PHPFGLTLYGERIYWTDWQTKSIQSADRL 974

Query: 52   ---------------------HTGTEHIEVTCL---NSTSHKILVSEDMDE-----PRAI 82
                                 H     +   C       SH  L S +        P  I
Sbjct: 975  TGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGI 1034

Query: 83   ALHPE-----MGLTYWIDWGENPEIKRANLDRQ---ELRVLVNASLGWPNGLALDLQEGK 134
             L  +      G+  ++ +    +I+  +LD     ++ V +N ++     + +D QEGK
Sbjct: 1035 NLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGK 1094

Query: 135  LYWGDAKTDKIEAISVDETKRQTLLKDKLPHI--FRFTLLGDFIYWT 179
            +YW D+   +I   ++D ++ + ++   L          +G  +YWT
Sbjct: 1095 VYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWT 1141


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score =  176 bits (446), Expect = 2e-44
 Identities = 92/242 (38%), Positives = 130/242 (53%), Gaps = 5/242 (2%)

Query: 2    EGHVYWTDDEVWA--IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
            E  +YWTD       IRR +L+GS  Q L  T +++PD +AV+WV  +LYW   G + IE
Sbjct: 3068 EQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIE 3127

Query: 60   VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
            V+ LN     +LVS  + EPRA+ +  + G  YW DWG++  I R  +D     V+V+  
Sbjct: 3128 VSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTK 3187

Query: 120  LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
            + WPNGL LD    ++YW DA+ D IE  S+D + R  +L   +PHIF  TL  D++YWT
Sbjct: 3188 ITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWT 3247

Query: 180  AWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNV--DKVVGTNPHADRNGGAATCASS 236
             W+  SI R HK    N+ ++I  L   M L   +      V  +P    NGG +     
Sbjct: 3248 DWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLL 3307

Query: 237  RP 238
             P
Sbjct: 3308 SP 3309



 Score =  173 bits (438), Expect = 1e-43
 Identities = 92/235 (39%), Positives = 136/235 (57%), Gaps = 15/235 (6%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
            +YW D  +  I RA  D +  + ++   I   + IAV+W+A ++YWT  G + IEV  LN
Sbjct: 1936 IYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLN 1995

Query: 65   STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
             +   +++S+ +D+PRAI +HPE G  +W +WG+ P I+R+ LD  E  VLVN S+ WPN
Sbjct: 1996 GSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPN 2055

Query: 125  GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
            G+++D Q+GKLYW DA+TDKIE I ++    R+ +L      +F  ++  DFIYW+   H
Sbjct: 2056 GISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTH 2115

Query: 184  --HSIKRVHKVKANRDVIIDQLP-------DLMGLKAVNVDKVVGTNPHADRNGG 229
               SIKR      ++D   D +P        L  +K  N D+  GTN  A  NGG
Sbjct: 2116 ANGSIKR-----GSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGG 2165



 Score =  124 bits (311), Expect = 8e-29
 Identities = 75/252 (29%), Positives = 133/252 (52%), Gaps = 16/252 (6%)

Query: 3   GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH-IEVT 61
           G +Y+ D   + I R  +DG+  +T++   I++ + +AV+W+  +LYWT  G +  I V 
Sbjct: 571 GFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVA 630

Query: 62  CLNSTSH--KILVSEDMDEPRAIALHPEMGLTYWIDWGENPE------IKRANLDRQELR 113
            L   +   K L+   M  PRAI + P  G  YW DW E+P+      ++RA +D     
Sbjct: 631 RLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRD 690

Query: 114 VLVNA-SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTL 171
           + V + ++ WPNGL+LD+  G+LYW DA  D+IE I ++ T R+ + +  +L H F    
Sbjct: 691 IFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCH 750

Query: 172 LGDFIYWTAWQHHSIKRVHK----VKANRDVIIDQLPDLMGLKAVNV-DKVVGTNPHADR 226
            G++++WT ++  S+ R+ +          ++  + P +  ++  +   + VGTN     
Sbjct: 751 HGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN 810

Query: 227 NGGAATCASSRP 238
           NGG ++   + P
Sbjct: 811 NGGCSSLCLATP 822



 Score =  121 bits (304), Expect = 5e-28
 Identities = 72/240 (30%), Positives = 122/240 (50%), Gaps = 10/240 (4%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQT----LINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
            +YWTD     I R  L  +GA T    +I   +  P+ +AV+W+A ++YW  +  + IEV
Sbjct: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370

Query: 61   TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVL--VN 117
              L+ T    L++ D++ PRAIAL P  G+ +W DW  + P I+ A++     R +    
Sbjct: 1371 AKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRET 1430

Query: 118  ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
             S GWPNGL +D  E ++ W DA++D I +   D +    +L+  + L H F  TL G  
Sbjct: 1431 GSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGE 1490

Query: 176  IYWTAWQHHSIKRVHKVKANRDVIIDQL-PDLMGLKAVNVDKVVGTNPHADRNGGAATCA 234
            +YWT W+ +++ + +K   +   ++ +       L+  +  +        + NGG   C+
Sbjct: 1491 VYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCS 1550



 Score =  119 bits (298), Expect = 3e-27
 Identities = 67/206 (32%), Positives = 101/206 (49%), Gaps = 17/206 (8%)

Query: 3    GHVYWTDDEVWAIRRAYLDGSGAQTLIN---------------TKINDPDDIAVNWVARS 47
            G VYWT+     I    L  +   T  N               + +  P  IA++WVA +
Sbjct: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971

Query: 48   LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
            +YWT +G + IEV  +   + K L+S  +DEP AI + P  G  YW DWG +P+I+ A +
Sbjct: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAM 4031

Query: 108  DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPH 165
            D      LV  ++ WP GLA+D    +LYW DAK   I +I ++ T        K  L H
Sbjct: 4032 DGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSH 4091

Query: 166  IFRFTLLGDFIYWTAWQHHSIKRVHK 191
             F   +  D+IY   + ++ + ++HK
Sbjct: 4092 PFSIDVFEDYIYGVTYINNRVFKIHK 4117



 Score =  107 bits (267), Expect = 1e-23
 Identities = 68/235 (28%), Positives = 119/235 (50%), Gaps = 13/235 (5%)

Query: 2    EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT--HTGTEHIE 59
            E  VYW+D    AI+RA+++G+G +T+++  + +   +AV+WV+R+L+WT   T  + I 
Sbjct: 1626 EQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQIN 1685

Query: 60   VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
            V  L+  S K  V + +++P  + +HP  G  YW D G+N  I  AN+D     +L +  
Sbjct: 1686 VARLDG-SFKNAVVQGLEQPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQ 1741

Query: 120  LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIY 177
             G P GLA+D  E KLYW  +    I   ++D +  + +  ++ +L       ++GD ++
Sbjct: 1742 KG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW 1800

Query: 178  WTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKV----VGTNPHADRNG 228
            W       +    K   +  V++     L+    V  + +     GTNP +  NG
Sbjct: 1801 WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNG 1855



 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 69/235 (29%), Positives = 111/235 (47%), Gaps = 11/235 (4%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
            ++++D     I++   DGS   T++   +   + +A +    +LYWT   T  I    ++
Sbjct: 2255 IFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313

Query: 65   STS------HKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVN 117
             T         ++     D PRA  L     L +W +W E +P I RA L    +  L+ 
Sbjct: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373

Query: 118  ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
              +  PNGLA+D +  KLY+ DA  DKIE    D + R  +LK +  H F   + G+ I+
Sbjct: 2374 KDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIF 2433

Query: 178  WTAWQHHSIKRVHK-VKANRDVIIDQLPDL-MGLKAV-NVDKVVGTNPHADRNGG 229
            WT W   +++R +K V +N  ++   +P   MG+ AV N       +P    NGG
Sbjct: 2434 WTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGG 2488



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 48/182 (26%), Positives = 99/182 (54%), Gaps = 7/182 (3%)

Query: 29  INTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEM 88
           I+  ++  + +A++W+  + Y+     + I V   N  +   L+  ++  P+ IAL P M
Sbjct: 275 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAM 334

Query: 89  GLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAI 148
           G  ++ D+G+ P+++R ++D Q    LV++ + +P+G+ LDL    +YW DA  D IE +
Sbjct: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394

Query: 149 SVDETKRQTLLKDKL-PHIFRFTLLGDFIYWT------AWQHHSIKRVHKVKANRDVIID 201
             +   RQT+++  L  H++  T+  +++Y T      A Q  S+ RV++  +    ++ 
Sbjct: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454

Query: 202 QL 203
           ++
Sbjct: 455 RV 456



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 5/157 (3%)

Query: 48   LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
            LY  H G   I +   N  S  ++          I  H E    YW+D G +  I RA  
Sbjct: 1894 LYSVHEGIRGIPLDP-NDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS-TISRAKR 1951

Query: 108  DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIF 167
            D+     +V   +G   G+A+D   G +YW D   D IE   ++ + R  ++   L    
Sbjct: 1952 DQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPR 2011

Query: 168  RFTLLGD--FIYWTAW-QHHSIKRVHKVKANRDVIID 201
              T+  +  +++WT W Q+  I+R       R V+++
Sbjct: 2012 AITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN 2048



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)

Query: 74  EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
           E++  PRA+  H E G  Y+ D   +  I R  +D  E   ++   +    G+A+D    
Sbjct: 556 ENLMNPRALDFHAETGFIYFAD-TTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGD 614

Query: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQ 182
            LYW   G  KT  +  +      R+TL++ K+ H     +  L  ++YWT W+
Sbjct: 615 NLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 31/120 (25%), Positives = 50/120 (41%), Gaps = 16/120 (13%)

Query: 81   AIALHPEMGLTYWIDWGEN--------PEIKRANLDRQELRV------LVNASLGWPNGL 126
            A+ +H + G  YW +W           P       +R   ++      L  + L  P G+
Sbjct: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963

Query: 127  ALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAWQHH 184
            A+D   G +YW D+  D IE   +    R+TL+   +  PH      L   +YW+ W +H
Sbjct: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 8/116 (6%)

Query: 3   GHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
           G V++TD  ++  + R  +DG     L+++KI  P  I ++ V+R +YW     ++IEV 
Sbjct: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394

Query: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVN 117
                  + ++       + I +    GLT + ++        AN  ++   + VN
Sbjct: 395 DYEGKGRQTII-------QGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVN 443



 Score = 38.1 bits (87), Expect = 0.007
 Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)

Query: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWT- 179
           P  L    + G +Y+ D  +  I    +D T+R+T+LKD + ++    +  +GD +YWT 
Sbjct: 561 PRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTD 620

Query: 180 --AWQHHSIKRVHKVKANRDVIID 201
               +  S+ R+ K    R  +I+
Sbjct: 621 DGPKKTISVARLEKAAQTRKTLIE 644



 Score = 33.9 bits (76), Expect = 0.14
 Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 18/193 (9%)

Query: 3    GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT-----GTEH 57
            G VYWTD     + +A        T++      P D+ V   +R     +      G   
Sbjct: 1489 GEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGP 1548

Query: 58   IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTY----WIDWGENPEIKRANLDRQELR 113
                CL + +  +  +     P  + LH +    Y    ++ +    EI+  +LD     
Sbjct: 1549 CSHLCLINYNRTVSCAC----PHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYN 1604

Query: 114  VLVNASLGWPNGLAL---DLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP--HIFR 168
             +++ ++   + + +   D +E ++YW D +T  I+   ++ T  +T++   LP  H   
Sbjct: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664

Query: 169  FTLLGDFIYWTAW 181
               +   ++WT++
Sbjct: 1665 VDWVSRNLFWTSY 1677



 Score = 30.8 bits (68), Expect = 1.2
 Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 5/55 (9%)

Query: 93   WIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALD--LQEGKLYWGDAKTDKI 145
            +I +    EI+R +L + +  VLV    G  N +ALD  L +  LYW D   DKI
Sbjct: 1270 FIIFSNRHEIRRIDLHKGDYSVLVP---GLRNTIALDFHLSQSALYWTDVVEDKI 1321


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score =  161 bits (407), Expect = 6e-40
 Identities = 87/230 (37%), Positives = 133/230 (57%), Gaps = 5/230 (2%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
            +YWTD     I RA  D +  + +I   +   + IAV+W+A ++YWT  G   IEV  LN
Sbjct: 1924 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 1983

Query: 65   STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
             +   +++S+ +D+PR+IA+HPE GL +W +WG+ P I +A LD  E  VLV+  + WPN
Sbjct: 1984 GSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPN 2043

Query: 125  GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWT--AW 181
            G+++D +E KLYW DA+TDKIE I ++    R+ +L      +F   + G +IYW+  A 
Sbjct: 2044 GISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAH 2103

Query: 182  QHHSIKRVHKVKANRDVII--DQLPDLMGLKAVNVDKVVGTNPHADRNGG 229
             + S++R HK  A   + +      +L  +K  N  +  GTN  A  NGG
Sbjct: 2104 ANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGG 2153



 Score =  130 bits (327), Expect = 1e-30
 Identities = 75/245 (30%), Positives = 128/245 (52%), Gaps = 10/245 (4%)

Query: 4   HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTG-TEHIEVTC 62
           ++Y+ D   + I R  +DG+  +T++   +++ + IAV+W+  +LYWT+ G  + I V  
Sbjct: 569 YIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVAR 628

Query: 63  LN--STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP------EIKRANLDRQELRV 114
           L   S S K L+  +M  PR I + P  G  YW DW E+        I++A +D    ++
Sbjct: 629 LEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQI 688

Query: 115 LVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK-LPHIFRFTLLG 173
            V + + WPNGL LD     LYW DA  D IE + ++ T R+ +   + L H F  +  G
Sbjct: 689 FVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG 748

Query: 174 DFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATC 233
           ++++WT + + SI ++  + +   ++  + P L GL+  +  K  G N     NGG +T 
Sbjct: 749 NYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTL 808

Query: 234 ASSRP 238
             + P
Sbjct: 809 CLAIP 813



 Score =  118 bits (295), Expect = 6e-27
 Identities = 66/193 (34%), Positives = 100/193 (51%), Gaps = 7/193 (3%)

Query: 2    EGHVYWTDDEV---WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHI 58
            E  +YW D        I R  L+GS  + + NT +  P+ +AV+W+ ++LYW+ T    I
Sbjct: 3054 EEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRII 3111

Query: 59   EVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNA 118
            EV+ LN     ILVS+ +  PR ++L P+ G  YWID  E P I R  +D     V++  
Sbjct: 3112 EVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIET 3171

Query: 119  SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYW 178
             +  P  L +D    +LYW D   + IE  ++D + R  +    +P +   TL  D+IYW
Sbjct: 3172 KISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYW 3229

Query: 179  TAWQHHSIKRVHK 191
            T  +  S+ R HK
Sbjct: 3230 TDGKTKSLSRAHK 3242



 Score =  114 bits (285), Expect = 8e-26
 Identities = 61/196 (31%), Positives = 103/196 (52%), Gaps = 9/196 (4%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQTLINTKIND----PDDIAVNWVARSLYWTHTGTEHIEV 60
            +YWTD     I R  L  SG  + I   +      P+ + V+W+A ++YW  +  + IEV
Sbjct: 1302 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 1361

Query: 61   TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVLVN-- 117
              L+ +    L++  M+ PRAIAL P  G+ +W DW  N P I+ A++     + +    
Sbjct: 1362 AKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDM 1421

Query: 118  ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
             +  WPNGL +D  E ++ W DA++D I +   D T    +++  + L H F  +L G  
Sbjct: 1422 KTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE 1481

Query: 176  IYWTAWQHHSIKRVHK 191
            +YWT W+ +++ + +K
Sbjct: 1482 VYWTDWRTNTLSKANK 1497



 Score = 95.5 bits (236), Expect = 4e-20
 Identities = 60/234 (25%), Positives = 113/234 (48%), Gaps = 8/234 (3%)

Query: 2    EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
            E  +YWTD +   I+RA+++G+G +T+I+  I     +AV+WV+R+LYW  +  +  ++ 
Sbjct: 1617 EERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQIN 1676

Query: 62   CLN-STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
                  S K  +   +D+P+ +A HP  G  YW D      I  AN+D    ++L   + 
Sbjct: 1677 VARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTINMANMDGSNSKILFQ-NQ 1732

Query: 121  GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIYW 178
              P GL++D  E KLYW  +    I   ++D    + +  +K++L      T++   ++W
Sbjct: 1733 KEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWW 1792

Query: 179  TAWQHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
                   +    K    N  ++ ++   ++ +K  + +   G+N     NGG +
Sbjct: 1793 ADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCS 1846



 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 18/181 (9%)

Query: 28   LINTKINDPDDIAVNWVARSLYWTHTGTEH---------------IEVTCLNSTSHKILV 72
            LI  +   P DIAV+WVA ++YWT     H               I V  LN  +   L+
Sbjct: 3963 LICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022

Query: 73   SEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQE 132
            +    EP AIA++P+ G+ YW   G++  I+ A +D    R+LV  +L  P GLA+D   
Sbjct: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFS 4082

Query: 133  GKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPHIFRFTLLGDFIYWTAWQHHSIKRVH 190
             ++YW D +   I ++  D +     +  K  L H  R  +  D+IY  A   + + RV 
Sbjct: 4083 ERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY-GAGPKNGVFRVQ 4141

Query: 191  K 191
            K
Sbjct: 4142 K 4142



 Score = 80.5 bits (197), Expect = 1e-15
 Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 12/213 (5%)

Query: 28   LINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNST-------SHKILVSEDMDEPR 80
            +I   +   + +A +    +LYWT + T  I    ++ T          I +SED D P 
Sbjct: 2263 VIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSED-DHPH 2321

Query: 81   AIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGD 139
             +AL     L +W +W E +P I R+ L  +  +V+V+  +  PNGL +D +  KLY+ D
Sbjct: 2322 VLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSD 2381

Query: 140  AKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVI 199
                KIE    D ++R  ++K          +  ++I+W+ W   +I R +K       I
Sbjct: 2382 GSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKI 2441

Query: 200  I--DQLPDLMGLKAV-NVDKVVGTNPHADRNGG 229
            +  D     MG+ AV N       +P A  NGG
Sbjct: 2442 LRSDIPHQPMGIIAVANDTNSCELSPCALLNGG 2474



 Score = 75.1 bits (183), Expect = 5e-14
 Identities = 38/154 (24%), Positives = 82/154 (53%), Gaps = 1/154 (0%)

Query: 39  IAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE 98
           +A++W+ R+LY+     + I V   N +    L+  ++  P+AIA+ P  G  ++ D+G 
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347

Query: 99  NPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL 158
             +++R ++D      ++++    P  LALDL    +YW D   D +  +      R T+
Sbjct: 348 VAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTV 407

Query: 159 LKDK-LPHIFRFTLLGDFIYWTAWQHHSIKRVHK 191
           ++ + + H++  T+  D++Y T   +++I R+++
Sbjct: 408 IQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR 441



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 35/123 (28%), Positives = 62/123 (50%), Gaps = 11/123 (8%)

Query: 1   MEGHVYWTD-------DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT 53
           + G +YWTD       D V  I +A++DG   Q  + +K+  P+ + +++   +LYW   
Sbjct: 655 VNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDA 714

Query: 54  GTEHIEVTCLNSTSHKILVS-EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
             +HIE   LN T  KI+ S  +++ P  ++ H      +W D+  N  I + +L   E+
Sbjct: 715 YYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG--NYVFWTDY-MNGSIFQLDLITSEV 771

Query: 113 RVL 115
            +L
Sbjct: 772 TLL 774



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 44/180 (24%), Positives = 71/180 (39%), Gaps = 29/180 (16%)

Query: 3    GHVYWTDDEV---------------WAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARS 47
            G++YWTD                  ++I    L+G     L+     +P  IAVN     
Sbjct: 3981 GNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4040

Query: 48   LYWTHTGT-EHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRAN 106
            +YWT  G   HIE   ++ T  +ILV +++  P  +A+       YW D+ E   I    
Sbjct: 4041 MYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF-ELSIIGSVL 4099

Query: 107  LDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIE------------AISVDETK 154
             D     V V++  G  +   +D+ E  +Y    K                 A+++D+TK
Sbjct: 4100 YDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTK 4159



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 6/118 (5%)

Query: 74  EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
           E++  PRA+  H E    Y+ D   +  I R  +D  E   ++   L    G+A+D    
Sbjct: 553 ENLVNPRALDFHAETNYIYFAD-TTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGN 611

Query: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSI 186
            LYW   G  KT  +  +      R+TLL+ ++ H     +  +  ++YWT W+   I
Sbjct: 612 NLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEI 669



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 12/118 (10%)

Query: 108  DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQ--------TLL 159
            D  E R ++  ++G   GLA       LYW  + T  I   +VD+T+          T+ 
Sbjct: 2256 DNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMS 2315

Query: 160  KDKLPHIFRFTLLGDFIYWTAW--QHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVD 215
            +D  PH+       + ++WT W  QH SI R      N  V++    D++    + +D
Sbjct: 2316 EDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVS--TDILTPNGLTID 2371



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 22/76 (28%), Positives = 42/76 (55%), Gaps = 1/76 (1%)

Query: 21  DGSGAQTLINTKINDPDDIAVNWVARSLYWTHTG-TEHIEVTCLNSTSHKILVSEDMDEP 79
           +GS   TLI+ ++++P  IAV+ +A  L++T  G    +E   ++  +   ++    ++P
Sbjct: 313 NGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQP 372

Query: 80  RAIALHPEMGLTYWID 95
            A+AL     L YW+D
Sbjct: 373 AALALDLVNKLVYWVD 388



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%)

Query: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTA 180
           P  L    +   +Y+ D  +  I    +D T+R+T+LKD L ++    +  +G+ +YWT 
Sbjct: 558 PRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTN 617

Query: 181 WQHH---SIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
             H    ++ R+ K   +R  +++   ++   + + VD V G
Sbjct: 618 DGHRKTINVARLEKASQSRKTLLE--GEMSHPRGIVVDPVNG 657



 Score = 33.9 bits (76), Expect = 0.14
 Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 8/123 (6%)

Query: 3    GHVYWTDDEVW--AIRRAYLDGSGAQTLINTKIND--PDDIAVNWVARSLYWTHTGTEHI 58
            G ++WTD +     I  A + G+G +T+         P+ + V+   + + WT   ++ I
Sbjct: 1390 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAI 1449

Query: 59   EVTCLNSTSHKILVS--EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLV 116
                 + T+   ++   E +  P A++L+      YW DW  N   K      Q + V+ 
Sbjct: 1450 YSALYDGTNMIEIIRGHEYLSHPFAVSLYGSE--VYWTDWRTNTLSKANKWTGQNVSVIQ 1507

Query: 117  NAS 119
              S
Sbjct: 1508 KTS 1510



 Score = 30.8 bits (68), Expect = 1.2
 Identities = 15/59 (25%), Positives = 31/59 (52%), Gaps = 1/59 (1%)

Query: 3   GHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           G +++TD   V  + R  +DG     +I++K   P  +A++ V + +YW     +++ V
Sbjct: 338 GKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGV 396



 Score = 28.5 bits (62), Expect = 5.8
 Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 2/94 (2%)

Query: 125  GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQ 182
            G+    +   +YW D   +KI     D+T ++ ++ + L  +    +  +   IYWT   
Sbjct: 1914 GIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHG 1973

Query: 183  HHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDK 216
             + I+      + R VII Q  D     AV+ +K
Sbjct: 1974 FNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEK 2007


>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
          Length = 4655

 Score =  144 bits (362), Expect = 1e-34
 Identities = 75/252 (29%), Positives = 123/252 (48%), Gaps = 10/252 (3%)

Query: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
            +E  +YW D +   I R +L+ +  +T+IN ++   + +AV+WV+R LYW     + + V
Sbjct: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296

Query: 61   TCLNSTSHKILVSEDMD--------EPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
            + LN    ++L    +D         PR +ALHP+ G  YW DWG    I R  +D    
Sbjct: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356

Query: 113  RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
             V+++  L WPNG+ +D     LYW DA    IE   ++   R T+    LPH F  T+ 
Sbjct: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416

Query: 173  GDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVN-VDKVVGTNPHADRNGGA 230
             D IYWT W   ++++ +K   +NR  +++       +   +   + + +NP    NGG 
Sbjct: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGC 3476

Query: 231  ATCASSRPTQPG 242
            +     +P   G
Sbjct: 3477 SHLCLIKPGGKG 3488



 Score =  132 bits (331), Expect = 4e-31
 Identities = 67/187 (35%), Positives = 109/187 (58%), Gaps = 10/187 (5%)

Query: 14   AIRRAYLDG--SGAQTLINTK------INDPDDIAVNWVARSLYWTHTGTEHIEVTCLNS 65
            AI+RAY+    SG   L+         +  PD IAV+WV R +YW+    + IEV  L+ 
Sbjct: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173

Query: 66   TSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNG 125
               K L+S D+D+P AIA++P++GL +W DWG+ P+I+ A ++ ++  +LV   LGWP G
Sbjct: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233

Query: 126  LALD-LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
            L++D L   ++YW D K D IE I  D T R+ + K+ + + +   +  D +YW + +  
Sbjct: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKG 4292

Query: 185  SIKRVHK 191
             + + +K
Sbjct: 4293 EVWKQNK 4299



 Score =  122 bits (307), Expect = 2e-28
 Identities = 70/239 (29%), Positives = 128/239 (53%), Gaps = 15/239 (6%)

Query: 5   VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
           ++++D     I +  +DG+G + L   ++ + + +A +W++++LYWT +  + I V  L 
Sbjct: 755 IFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLA 814

Query: 65  STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
             + + +V + ++ PR++ +HP  G  ++ DW    +I RA  D   L  ++N +LGWPN
Sbjct: 815 DKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPN 873

Query: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTLLGDFIYWTAWQH 183
           GLA+D    +LYW DA  DKIE  + D   R+ L   +++ H F   + G+ +++T W+ 
Sbjct: 874 GLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRL 933

Query: 184 HSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQP 241
            +I RV K       VI   +  ++ LK+ +V+   G+N            A ++PT P
Sbjct: 934 GAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSN------------ACNQPTHP 980



 Score =  120 bits (301), Expect = 1e-27
 Identities = 66/221 (29%), Positives = 118/221 (53%), Gaps = 5/221 (2%)

Query: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
            + G ++W+D        A+ +G+  + + ++ I   + IA++WV R+LYWT    E IEV
Sbjct: 1476 ISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEV 1535

Query: 61   TCLNSTSHKILVSEDMDEPRAIALHPEMG--LTYWIDWGENPEIKRANLDRQELRVLVNA 118
            + ++ +   +L+S+++  PR +AL P M   L +W DWG +P I+RA++D     V+V  
Sbjct: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595

Query: 119  SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDK-LPHIFRFTLLGDFI 176
             + WP GL +D     LY+ D+  D ++    +   +RQ +  D  + H +  TL  D +
Sbjct: 1596 KIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSV 1655

Query: 177  YWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNVDK 216
            YWT      + R +K    N+ V++  +   +G+ AV+  K
Sbjct: 1656 YWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696



 Score =  120 bits (300), Expect = 1e-27
 Identities = 68/243 (27%), Positives = 123/243 (50%), Gaps = 8/243 (3%)

Query: 5   VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
           V+WTD     +    ++G   Q ++N  +  P+++AV+WV   +Y   T    I++  L+
Sbjct: 438 VFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLD 497

Query: 65  STSHKILVSEDMDEPRAIALHPEMGLTYWIDW---GENPEIKRANLDRQELRVLVNASLG 121
            +    L++E++  PR IA+ P +G  ++ DW      P+++RA +D    + LV   LG
Sbjct: 498 GSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLG 557

Query: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWT 179
           WP G+ LD+   ++YW D++ D IE ++ D  +R+T++     +PH F  +L    +++T
Sbjct: 558 WPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFT 617

Query: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAV-NVDKVVGTNPHADRNGGA-ATCASS 236
            W   ++ + +K  + N  V         G+    ++ +   TNP  D NGG    C  S
Sbjct: 618 DWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLS 677

Query: 237 RPT 239
             T
Sbjct: 678 HRT 680



 Score =  101 bits (251), Expect = 7e-22
 Identities = 66/220 (30%), Positives = 104/220 (47%), Gaps = 6/220 (2%)

Query: 22   GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRA 81
            G    T+I + I   D IA +W+ R +Y++    + I     + ++  ++    + +PRA
Sbjct: 2454 GIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRA 2511

Query: 82   IALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAK 141
            I L P  G  YW DW  + +I+RA L       +VN+SL  P+GL LD +E  LYW DA 
Sbjct: 2512 IVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDAS 2571

Query: 142  TDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVII- 200
              +IE  ++    R+ ++   + H F  TL G +IYWT      I R +K   +  + + 
Sbjct: 2572 LQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMT 2630

Query: 201  -DQLPDLMGLK-AVNVDKVVGTNPHADRNGGAATCASSRP 238
             + L    G+   V   K    NP    NGG +   +  P
Sbjct: 2631 TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGP 2670



 Score = 99.4 bits (246), Expect = 3e-21
 Identities = 79/263 (30%), Positives = 119/263 (45%), Gaps = 22/263 (8%)

Query: 3    GHVYWTDDEVW-----AIRRAYLDGSGAQTLINTKI--NDPDDIAVNWVARSLYWTHTGT 55
            G +YW D         AIRR   DGS    ++   I  N    IAV+WVA +LY+T+   
Sbjct: 2107 GFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFV 2166

Query: 56   EH--IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELR 113
                IEV  +N+T  ++L+   +D PR I + P+    +W D+G+ P+I+R+ LD     
Sbjct: 2167 SETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRT 2226

Query: 114  VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDKLPHIFRFTLL 172
            VLV+  +  P GLA+D  +G +YW D   D I  I ++ E         + P  +  T+ 
Sbjct: 2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVF 2286

Query: 173  GDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNV-DK--------VVGTNPH 223
             + I W       I +  K   N +       ++  L+ V + DK         V  NP 
Sbjct: 2287 ENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPC 2346

Query: 224  ADRNGGAATCASSRPTQPGLAAP 246
             + NGG   C+      PGL  P
Sbjct: 2347 LENNGG---CSHLCFALPGLHTP 2366



 Score = 94.7 bits (234), Expect = 7e-20
 Identities = 68/222 (30%), Positives = 112/222 (50%), Gaps = 15/222 (6%)

Query: 2    EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPD-DIAVNWVARSLYWTHTGTEHIEV 60
            E ++YW ++    I R   DG+      +  +  P  ++A++W++R+LY T+  T+ IEV
Sbjct: 1789 EQYIYWVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEV 1847

Query: 61   TCLNSTSH--KILVSED-----MDEPRAIALHPEMGLTYWIDWGENP----EIKRANLDR 109
              L+      K L++ D     +  P  I + P  G  YW D G +     +I  AN+D 
Sbjct: 1848 LTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDG 1907

Query: 110  QELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRF 169
              ++ L   +L     + LD++E KLYW       IE  +VD T R  +L  +L H +  
Sbjct: 1908 TSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRM-ILVHQLSHPWGI 1966

Query: 170  TLLGDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLK 210
             +   F+Y+T  Q+  I+RV K   AN+ V+ D +P+L GL+
Sbjct: 1967 AVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQ 2008



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 6/136 (4%)

Query: 4    HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
            H+YW+D +   I  A LDG   + LI+T ++ P  IAVN     ++WT  G E  IE   
Sbjct: 4155 HIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAW 4214

Query: 63   LNSTSHKILVSEDMDEPRAIAL-HPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
            +N     ILV ED+  P  +++ +      YW D+ E+  I+    D  + RV+   ++ 
Sbjct: 4215 MNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED-VIETIKYDGTDRRVIAKEAM- 4272

Query: 122  WPNGLALDLQEGKLYW 137
              N  +LD+ E +LYW
Sbjct: 4273 --NPYSLDIFEDQLYW 4286



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 4/95 (4%)

Query: 2    EGHVYWTDDEVWA-IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
            +G++YW D +  A I RA L G+    ++N+ +  P  + +++    LYW     + IE 
Sbjct: 2518 QGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIER 2577

Query: 61   TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWID 95
            + L     +++V+  +    A  L       YW D
Sbjct: 2578 STLTGVDREVIVNAAV---HAFGLTLYGQYIYWTD 2609



 Score = 33.5 bits (75), Expect = 0.18
 Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 2/46 (4%)

Query: 121  GWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP 164
            G  N +ALD    E +LYW D +   IE + +++T ++T++  +LP
Sbjct: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLP 3270



 Score = 27.7 bits (60), Expect = 9.9
 Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 6/53 (11%)

Query: 2    EGHVYWTDDEVWAIRRAYLDGSGAQTL-INTKINDPDDI-----AVNWVARSL 48
            +G+VYW DD +  I R  ++G  ++ +   ++   P  I     ++ WV R+L
Sbjct: 2245 DGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNL 2297


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
           sapiens]
          Length = 1207

 Score =  135 bits (341), Expect = 3e-32
 Identities = 76/239 (31%), Positives = 125/239 (52%), Gaps = 3/239 (1%)

Query: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +E  +Y+    +  I RA +DGS  + LI   ++ P+ +AV+W+ R  YWT  G   I  
Sbjct: 522 VENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGR 581

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
           + LN    KI+  E++ +PR IA+HP     +W D G NP I+ ++L      V+ ++ L
Sbjct: 582 SDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDL 641

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
            WP+G+ +D    KLYW DAK   IE  ++D +KR+ L ++ + H F   +  D+++++ 
Sbjct: 642 IWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD 701

Query: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVV--GTNPHADRNGGAATCASSR 237
           W   S+ RV+K +  +D +  Q   L     V V  +   G +P   +NGG       R
Sbjct: 702 WAMPSVMRVNK-RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKR 759



 Score = 57.8 bits (138), Expect = 9e-09
 Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 8/189 (4%)

Query: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
           E  +YW D E   ++R +L+GS  + + N + N    +A+NW+   + W++     I VT
Sbjct: 85  EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKN-VSGMAINWINEEVIWSNQQEGIITVT 143

Query: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
            +   +  IL+S  +  P  +A+ P     +W        + RA+LD   ++ L+  S  
Sbjct: 144 DMKGNNSHILLSA-LKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALLETS-E 200

Query: 122 WPNGLALDLQEGKLYW----GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
               ++LD+ + +L+W     +     I +   D             ++F  +L GD I+
Sbjct: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIF 260

Query: 178 WTAWQHHSI 186
           ++ W+  +I
Sbjct: 261 YSTWKMKTI 269



 Score = 28.1 bits (61), Expect = 7.6
 Identities = 13/56 (23%), Positives = 29/56 (51%), Gaps = 1/56 (1%)

Query: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE 56
           +E  ++W+ +   ++ RA LDG G + L+ T       ++++ + + L+W     E
Sbjct: 168 VERFIFWSSEVAGSLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNRE 222


>gi|61744471 low density lipoprotein receptor-related protein 8
           isoform 1 precursor [Homo sapiens]
          Length = 963

 Score =  132 bits (333), Expect = 2e-31
 Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)

Query: 5   VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +YW D     I  AY+D +      + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
             ++    + L S ++ EPRAIA+ P  G  YW DWG+  +I+++ L+  + + LV+ ++
Sbjct: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
            WPNG+ LDL   +LYW D+K  ++ +I      R+TL+   D L H F   +  D ++W
Sbjct: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643

Query: 179 TAWQHHSI 186
           T  ++ +I
Sbjct: 644 TDLENEAI 651



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)

Query: 4   HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
           H+YWTD     I  A +DG   +TL +  +++P  IAV+ +   +YW+  G +  IE + 
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569

Query: 63  LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
           LN    + LVS++++ P  I L       YW+D  +  ++   +      + L++++  L
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 628

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
             P G+A  + E K++W D + + I
Sbjct: 629 SHPFGIA--VFEDKVFWTDLENEAI 651


>gi|61744467 low density lipoprotein receptor-related protein 8
           isoform 3 precursor [Homo sapiens]
          Length = 700

 Score =  132 bits (333), Expect = 2e-31
 Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)

Query: 5   VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +YW D     I  AY+D +      + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 335 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 394

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
             ++    + L S ++ EPRAIA+ P  G  YW DWG+  +I+++ L+  + + LV+ ++
Sbjct: 395 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 454

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
            WPNG+ LDL   +LYW D+K  ++ +I      R+TL+   D L H F   +  D ++W
Sbjct: 455 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 514

Query: 179 TAWQHHSI 186
           T  ++ +I
Sbjct: 515 TDLENEAI 522



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)

Query: 4   HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
           H+YWTD     I  A +DG   +TL +  +++P  IAV+ +   +YW+  G +  IE + 
Sbjct: 381 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 440

Query: 63  LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
           LN    + LVS++++ P  I L       YW+D  +  ++   +      + L++++  L
Sbjct: 441 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 499

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
             P G+A  + E K++W D + + I
Sbjct: 500 SHPFGIA--VFEDKVFWTDLENEAI 522


>gi|66082554 low density lipoprotein receptor-related protein 8
           isoform 2 precursor [Homo sapiens]
          Length = 793

 Score =  132 bits (333), Expect = 2e-31
 Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)

Query: 5   VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +YW D     I  AY+D +      + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 294 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 353

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
             ++    + L S ++ EPRAIA+ P  G  YW DWG+  +I+++ L+  + + LV+ ++
Sbjct: 354 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 413

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
            WPNG+ LDL   +LYW D+K  ++ +I      R+TL+   D L H F   +  D ++W
Sbjct: 414 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 473

Query: 179 TAWQHHSI 186
           T  ++ +I
Sbjct: 474 TDLENEAI 481



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)

Query: 4   HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
           H+YWTD     I  A +DG   +TL +  +++P  IAV+ +   +YW+  G +  IE + 
Sbjct: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 399

Query: 63  LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
           LN    + LVS++++ P  I L       YW+D  +  ++   +      + L++++  L
Sbjct: 400 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 458

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
             P G+A  + E K++W D + + I
Sbjct: 459 SHPFGIA--VFEDKVFWTDLENEAI 481


>gi|65301119 low density lipoprotein receptor-related protein 8
           isoform 4 precursor [Homo sapiens]
          Length = 904

 Score =  132 bits (333), Expect = 2e-31
 Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)

Query: 5   VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +YW D     I  AY+D +      + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
             ++    + L S ++ EPRAIA+ P  G  YW DWG+  +I+++ L+  + + LV+ ++
Sbjct: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
            WPNG+ LDL   +LYW D+K  ++ +I      R+TL+   D L H F   +  D ++W
Sbjct: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643

Query: 179 TAWQHHSI 186
           T  ++ +I
Sbjct: 644 TDLENEAI 651



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)

Query: 4   HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTE-HIEVTC 62
           H+YWTD     I  A +DG   +TL +  +++P  IAV+ +   +YW+  G +  IE + 
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569

Query: 63  LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS--L 120
           LN    + LVS++++ P  I L       YW+D  +  ++   +      + L++++  L
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD-SKLHQLSSIDFSGGNRKTLISSTDFL 628

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKI 145
             P G+A  + E K++W D + + I
Sbjct: 629 SHPFGIA--VFEDKVFWTDLENEAI 651


>gi|144953895 nidogen 2 precursor [Homo sapiens]
          Length = 1375

 Score =  127 bits (320), Expect = 7e-30
 Identities = 73/215 (33%), Positives = 116/215 (53%), Gaps = 5/215 (2%)

Query: 2    EGHVYWTDDEVWAIRRAYLD-GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
            E  VYWTD     I RA L+ G+  +T++N+ +  P+ +A++ + R++YWT +  + IE 
Sbjct: 1153 ERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIES 1212

Query: 61   TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNAS 119
              L+ +  K+L   D+  PRAIA+ P  G  YW DW  E P+I+ ++LD +  R+L+N  
Sbjct: 1213 ALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1272

Query: 120  LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
            +G PNGL  D     L W DA T K+E    D T R+ ++++ L + F      D  Y T
Sbjct: 1273 IGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVSYADHFYHT 1331

Query: 180  AWQHHSIKRV--HKVKANRDVIIDQLPDLMGLKAV 212
             W+   +  V  H  +   + + +Q   L G+ AV
Sbjct: 1332 DWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366


>gi|65301164 very low density lipoprotein receptor isoform b [Homo
           sapiens]
          Length = 845

 Score =  126 bits (316), Expect = 2e-29
 Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)

Query: 5   VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
           ++W D    AI  A +D   G    +   + +P  IAV+WV +++YWT   ++ I V  L
Sbjct: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542

Query: 64  NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
           + T  K L + D+ EP +IA+ P  G  YW DWGE  +I++A ++  + R LV A + WP
Sbjct: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602

Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181
           NG+ LDL + +LYW D+K   + ++ ++   R+ +LK  + L H    T+  D +YW   
Sbjct: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662

Query: 182 QHHSIKRVHK 191
           ++ ++   +K
Sbjct: 663 ENEAVYGANK 672


>gi|65301167 very low density lipoprotein receptor isoform a [Homo
           sapiens]
          Length = 873

 Score =  126 bits (316), Expect = 2e-29
 Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)

Query: 5   VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
           ++W D    AI  A +D   G    +   + +P  IAV+WV +++YWT   ++ I V  L
Sbjct: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542

Query: 64  NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
           + T  K L + D+ EP +IA+ P  G  YW DWGE  +I++A ++  + R LV A + WP
Sbjct: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602

Query: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181
           NG+ LDL + +LYW D+K   + ++ ++   R+ +LK  + L H    T+  D +YW   
Sbjct: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662

Query: 182 QHHSIKRVHK 191
           ++ ++   +K
Sbjct: 663 ENEAVYGANK 672


>gi|4504975 low density lipoprotein receptor precursor [Homo
           sapiens]
          Length = 860

 Score =  125 bits (314), Expect = 4e-29
 Identities = 64/181 (35%), Positives = 97/181 (53%), Gaps = 6/181 (3%)

Query: 5   VYWTDDEVWAIRRAYLDG----SGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
           +YW+D     I    LD     S   T+I+  I  PD +AV+W+  ++YWT +    + V
Sbjct: 441 IYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSV 500

Query: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
                   K L  E+  +PRAI + P  G  YW DWG   +IK+  L+  ++  LV  ++
Sbjct: 501 ADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI 560

Query: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKD--KLPHIFRFTLLGDFIYW 178
            WPNG+ LDL  G+LYW D+K   I +I V+   R+T+L+D  +L H F   +  D ++W
Sbjct: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620

Query: 179 T 179
           T
Sbjct: 621 T 621


>gi|4507157 sortilin-related receptor containing LDLR class A repeats
            preproprotein [Homo sapiens]
          Length = 2214

 Score =  122 bits (306), Expect = 3e-28
 Identities = 73/221 (33%), Positives = 120/221 (54%), Gaps = 7/221 (3%)

Query: 5    VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
            +YW+D  +  I+R  L+GS G + +IN+ +   + +A   +++ LYW   G + IEV   
Sbjct: 802  LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861

Query: 64   NSTSHKILVSED-MDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLG 121
            +      +V+   +D PRA+ L P+ G+ +W DWG+  P I R+N+D      LV+  + 
Sbjct: 862  DGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK 921

Query: 122  WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
            WPNG+++D Q   +YW DA  + IE I+    +R  +L D LPH +   +  + IYW  W
Sbjct: 922  WPNGISVDDQ--WIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDW 978

Query: 182  QHHSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTN 221
               SI R  K   ++ +++ +QL  LM +K     K  G+N
Sbjct: 979  SQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSN 1019


>gi|115298674 nidogen 1 precursor [Homo sapiens]
          Length = 1247

 Score =  120 bits (302), Expect = 9e-28
 Identities = 64/183 (34%), Positives = 99/183 (54%), Gaps = 2/183 (1%)

Query: 5    VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
            VYWTD    +I RA L G    T+I   +  P+ IAV+ + R+++WT +  + IEV  L+
Sbjct: 992  VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD 1051

Query: 65   STSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNASLGWP 123
             T  ++L   D+  PR I      G  YW DW  +NP+I+ + +D    R+LV   LG P
Sbjct: 1052 GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLP 1111

Query: 124  NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
            NGL  D    +L W DA T++ E ++  +  R+  L + L + F  T  G  +Y+T W+ 
Sbjct: 1112 NGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKM 1170

Query: 184  HSI 186
            +S+
Sbjct: 1171 NSV 1173



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 29/98 (29%), Positives = 50/98 (51%), Gaps = 2/98 (2%)

Query: 4    HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH--IEVT 61
            +++WTD  +  I  A LDG+  + L  T + +P  I  + V  +LYWT    ++  IE +
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093

Query: 62   CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN 99
             ++ T+ +ILV +D+  P  +          W+D G N
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 1131



 Score = 29.3 bits (64), Expect = 3.4
 Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 4/105 (3%)

Query: 125  GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAWQ 182
            GLA D  +  +YW D     I   S+   +  T+++  L  P       LG  I+WT   
Sbjct: 982  GLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSN 1041

Query: 183  HHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRN 227
               I+        R V+ +   DL+  + +  D V G     D N
Sbjct: 1042 LDRIEVAKLDGTQRRVLFE--TDLVNPRGIVTDSVRGNLYWTDWN 1084


>gi|226498382 tetratricopeptide repeat domain 5 [Homo sapiens]
          Length = 440

 Score = 30.4 bits (67), Expect = 1.5
 Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 7/105 (6%)

Query: 3   GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTC 62
           G VYW   +V A    +   SGA T    K++  +   ++ V R L  T T  EH     
Sbjct: 110 GEVYWKKGDVAAAHTCF---SGALTHCRNKVSLQN---LSMVLRQLR-TDTEDEHSHHVM 162

Query: 63  LNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
            +    K+ V  D+ + R+  +     L+ +   G+NP+I +  L
Sbjct: 163 DSVRQAKLAVQMDVHDGRSWYILGNSYLSLYFSTGQNPKISQQAL 207


>gi|112807226 hypothetical protein LOC91748 [Homo sapiens]
          Length = 1045

 Score = 29.3 bits (64), Expect = 3.4
 Identities = 12/28 (42%), Positives = 13/28 (46%)

Query: 225 DRNGGAATCASSRPTQPGLAAPSRAWNC 252
           +R GG     SS   QPG   P   WNC
Sbjct: 109 ERGGGGGVSDSSWQQQPGQPPPHSTWNC 136


>gi|6005705 G protein-coupled receptor 182 [Homo sapiens]
          Length = 404

 Score = 29.3 bits (64), Expect = 3.4
 Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 2/42 (4%)

Query: 51  THTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTY 92
           T  GT     +C  ST H I++++   +P A A HPE  L++
Sbjct: 344 TKAGTCASSSSC--STQHSIIITKGDSQPAAAAPHPEPSLSF 383


>gi|44890062 hypothetical protein LOC91748 [Homo sapiens]
          Length = 1045

 Score = 29.3 bits (64), Expect = 3.4
 Identities = 12/28 (42%), Positives = 13/28 (46%)

Query: 225 DRNGGAATCASSRPTQPGLAAPSRAWNC 252
           +R GG     SS   QPG   P   WNC
Sbjct: 109 ERGGGGGVSDSSWQQQPGQPPPHSTWNC 136


>gi|33589848 transferrin receptor 2 [Homo sapiens]
          Length = 801

 Score = 28.9 bits (63), Expect = 4.5
 Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 3/39 (7%)

Query: 128 LDLQEGKLYWGDAKTDKIEAIS---VDETKRQTLLKDKL 163
           LD  +G+LYW D +   ++ +    +++T RQT L++++
Sbjct: 128 LDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERV 166


>gi|169208029 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 134

 Score = 28.1 bits (61), Expect = 7.6
 Identities = 12/32 (37%), Positives = 16/32 (50%)

Query: 220 TNPHADRNGGAATCASSRPTQPGLAAPSRAWN 251
           + PHA  +      A+ R T PG   PS AW+
Sbjct: 66  STPHAPLSASGEHPATPRHTHPGYIPPSHAWS 97


>gi|239755684 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 415

 Score = 27.7 bits (60), Expect = 9.9
 Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 17/101 (16%)

Query: 20  LDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEP 79
           +D  G+Q  IN K+ND + +         +      + I    +     +  VS   ++P
Sbjct: 91  VDNHGSQQDINHKVNDTEQL------EDAHGNEFALKLIGHATVGGFQTRSAVSSSAEQP 144

Query: 80  RAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
            +  ++P+            P+ +R NL+R  L VL N  L
Sbjct: 145 PS-NMNPQ----------RQPDARRKNLERNSLSVLTNRDL 174


>gi|239750147 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 415

 Score = 27.7 bits (60), Expect = 9.9
 Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 17/101 (16%)

Query: 20  LDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEP 79
           +D  G+Q  IN K+ND + +         +      + I    +     +  VS   ++P
Sbjct: 91  VDNHGSQQDINHKVNDTEQL------EDAHGNEFALKLIGHATVGGFQTRSAVSSSAEQP 144

Query: 80  RAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
            +  ++P+            P+ +R NL+R  L VL N  L
Sbjct: 145 PS-NMNPQ----------RQPDARRKNLERNSLSVLTNRDL 174


>gi|239744457 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 351

 Score = 27.7 bits (60), Expect = 9.9
 Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 17/101 (16%)

Query: 20  LDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEP 79
           +D  G+Q  IN K+ND + +         +      + I    +     +  VS   ++P
Sbjct: 27  VDNHGSQQDINHKVNDTEQL------EDAHGNEFALKLIGHATVGGFQTRSAVSSSAEQP 80

Query: 80  RAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
            +  ++P+            P+ +R NL+R  L VL N  L
Sbjct: 81  PS-NMNPQ----------RQPDARRKNLERNSLSVLTNRDL 110


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,100,017
Number of Sequences: 37866
Number of extensions: 418084
Number of successful extensions: 1255
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 865
Number of HSP's gapped (non-prelim): 120
length of query: 252
length of database: 18,247,518
effective HSP length: 100
effective length of query: 152
effective length of database: 14,460,918
effective search space: 2198059536
effective search space used: 2198059536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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