BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo sapiens] (1248 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 2554 0.0 gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 2524 0.0 gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 2360 0.0 gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 2330 0.0 gi|32483363 apoptotic peptidase activating factor 1 isoform e [H... 634 0.0 gi|16554629 WD repeat domain 5 [Homo sapiens] 123 1e-27 gi|16554627 WD repeat domain 5 [Homo sapiens] 123 1e-27 gi|32189425 WD repeat domain 69 [Homo sapiens] 120 1e-26 gi|23199987 WD repeat domain 5B [Homo sapiens] 117 7e-26 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 108 2e-23 gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 105 2e-22 gi|21536371 telomerase-associated protein 1 [Homo sapiens] 105 3e-22 gi|113865883 WD repeat domain 38 [Homo sapiens] 104 5e-22 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 103 8e-22 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 102 2e-21 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 102 2e-21 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 102 2e-21 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 101 5e-21 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 100 7e-21 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 100 7e-21 gi|148727341 serine/threonine kinase receptor associated protein... 100 9e-21 gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 100 1e-20 gi|26665869 WD repeat domain 51B [Homo sapiens] 99 2e-20 gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 96 2e-19 gi|5174447 guanine nucleotide binding protein (G protein), beta ... 96 3e-19 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 94 8e-19 gi|13376840 WD repeat domain 61 [Homo sapiens] 93 2e-18 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 90 1e-17 gi|21071067 TBP-associated factor 5 [Homo sapiens] 90 2e-17 gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 90 2e-17 >gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo sapiens] Length = 1248 Score = 2554 bits (6619), Expect = 0.0 Identities = 1248/1248 (100%), Positives = 1248/1248 (100%) Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 Query: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 Query: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 Query: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 Query: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD Sbjct: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360 Query: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN Sbjct: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420 Query: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC Sbjct: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480 Query: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV Sbjct: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540 Query: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK Sbjct: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600 Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 Query: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS Sbjct: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 Query: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780 Query: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840 Query: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS Sbjct: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900 Query: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT Sbjct: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960 Query: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS Sbjct: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020 Query: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD Sbjct: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST Sbjct: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK Sbjct: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200 Query: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248 >gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo sapiens] Length = 1237 Score = 2524 bits (6542), Expect = 0.0 Identities = 1237/1248 (99%), Positives = 1237/1248 (99%), Gaps = 11/1248 (0%) Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109 Query: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG Sbjct: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169 Query: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL Sbjct: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229 Query: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN Sbjct: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289 Query: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD Sbjct: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349 Query: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN Sbjct: 350 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409 Query: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC Sbjct: 410 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469 Query: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV Sbjct: 470 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529 Query: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK Sbjct: 530 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589 Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV Sbjct: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649 Query: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS Sbjct: 650 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709 Query: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS Sbjct: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769 Query: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH Sbjct: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 829 Query: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS Sbjct: 830 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889 Query: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT Sbjct: 890 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 949 Query: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS Sbjct: 950 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009 Query: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD Sbjct: 1010 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST Sbjct: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK Sbjct: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1189 Query: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE Sbjct: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237 >gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo sapiens] Length = 1205 Score = 2360 bits (6116), Expect = 0.0 Identities = 1170/1248 (93%), Positives = 1179/1248 (94%), Gaps = 43/1248 (3%) Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 Query: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 Query: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 Query: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 Query: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD Sbjct: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360 Query: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN Sbjct: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420 Query: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC Sbjct: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480 Query: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV Sbjct: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540 Query: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK Sbjct: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600 Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 Query: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS Sbjct: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 Query: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780 Query: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL++ + + + GH Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR-GHL 839 Query: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900 S + FSP + + + LW Sbjct: 840 SWVHGVMFSPDGSSFLTSSDDQTIRLW--------------------------------- 866 Query: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960 ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT Sbjct: 867 ---------ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 917 Query: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS Sbjct: 918 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 977 Query: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD Sbjct: 978 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1037 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST Sbjct: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK Sbjct: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1157 Query: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE Sbjct: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1205 >gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo sapiens] Length = 1194 Score = 2330 bits (6039), Expect = 0.0 Identities = 1159/1248 (92%), Positives = 1168/1248 (93%), Gaps = 54/1248 (4%) Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109 Query: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG Sbjct: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169 Query: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL Sbjct: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229 Query: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN Sbjct: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289 Query: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD Sbjct: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349 Query: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN Sbjct: 350 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409 Query: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC Sbjct: 410 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469 Query: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV Sbjct: 470 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529 Query: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK Sbjct: 530 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589 Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV Sbjct: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649 Query: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS Sbjct: 650 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709 Query: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS Sbjct: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769 Query: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL++ + + + GH Sbjct: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR-GHL 828 Query: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900 S + FSP + + + LW Sbjct: 829 SWVHGVMFSPDGSSFLTSSDDQTIRLW--------------------------------- 855 Query: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960 ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT Sbjct: 856 ---------ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 906 Query: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS Sbjct: 907 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 966 Query: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD Sbjct: 967 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1026 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST Sbjct: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1086 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK Sbjct: 1087 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1146 Query: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE Sbjct: 1147 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194 >gi|32483363 apoptotic peptidase activating factor 1 isoform e [Homo sapiens] Length = 338 Score = 634 bits (1636), Expect = 0.0 Identities = 322/338 (95%), Positives = 326/338 (96%), Gaps = 3/338 (0%) Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60 Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120 Query: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180 Query: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240 Query: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300 Query: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRW 338 MKKADLPEQAHSIIKECK +V +L D ++W Sbjct: 301 MKKADLPEQAHSIIKECK---VVERCHWGILTDLLHKW 335 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 123 bits (309), Expect = 1e-27 Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D + Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+ Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793 +C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213 Query: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 849 + + +S +G I+ A N + L+D ++ G + +TGH + +YC +FS Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267 Query: 850 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 906 +V+ S+ V +WN ++ V +GH V P + +++ +D+TI Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 Query: 907 RLWET 911 +LW++ Sbjct: 328 KLWKS 332 Score = 103 bits (258), Expect = 8e-22 Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203 Query: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792 +C T+ N V+ +FSP+ K + + + D TLKLWD + K+ Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253 Query: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 850 E ++S G + +V+ N ++++++ T ++ ++ I Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 Query: 851 QNHLAVVAL-SQYCVELWNTD 870 +N +A AL + ++LW +D Sbjct: 313 ENIIASAALENDKTIKLWKSD 333 Score = 93.6 bits (231), Expect = 1e-18 Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%) Query: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712 + H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+ Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 Query: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772 LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 Query: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 831 + K++ DP V ++ DG+ I+ ++ + + ++D + Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 Query: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 889 L + + + + FSP + A ++LW+ + GH + + + Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 Query: 890 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 940 FS G ++ S S+D + +W +TK++ + L+ DVV EN + A+ Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321 Query: 941 DHIRRLQL 948 ++ + ++L Sbjct: 322 ENDKTIKL 329 Score = 86.3 bits (212), Expect = 2e-16 Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%) Query: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797 T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92 Query: 798 EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 857 +WS+D ++ A+ +K +SG + GH + + C+F+PQ++L V Sbjct: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 Query: 858 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 917 V +W+ + + H V V F+ DGS ++SS D R+W+T Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201 Query: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977 S LK +D +N VS SP+ +YI Sbjct: 202 SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230 Query: 978 FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1034 + +++ + + ++ HK + I F+ K ++S S+D + +WN Q Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 Query: 1035 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1070 + + L+GH + V +++ + D T+K+W Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 Score = 80.1 bits (196), Expect = 1e-14 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%) Query: 1040 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1098 L GH + V + N L S S D +K+W G EK H+ + S D+ Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 Query: 1099 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158 S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 Query: 1159 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1212 G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T Sbjct: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208 Score = 73.2 bits (178), Expect = 1e-12 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%) Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670 ++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184 Query: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242 Query: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771 ++ +C T GH N +C F+ K + S S D + +W+ Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 Score = 70.1 bits (170), Expect = 1e-11 Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + FSP + + +++W GH + V +S D + Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 Query: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957 +++SDD+T+++W+ V + L+ + G + Sbjct: 103 VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131 Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 V CC +P I G + ++ I ++ + ++ H V + F D Sbjct: 132 ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185 Query: 1018 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074 ++SSS D ++W+ +C+ + V + N + +L+ + D T+K+W+ Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1131 G K + H+ + T S S D IW+ + +L+GH V Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305 Query: 1132 CSAFSVDSTLLATG--DDNGEIRIW 1154 +A ++A+ +++ I++W Sbjct: 306 STACHPTENIIASAALENDKTIKLW 330 Score = 61.6 bits (148), Expect = 4e-09 Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 GH V V FSP+G +SS D+ I++W D F++ Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82 Query: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 I+G + +S S + ++ ++I ++ + + ++ Sbjct: 83 ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 Query: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1058 H V+ F ++S S D +++W+ + KC+ L H + V ++ L Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185 Query: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1116 + S S+DG ++W+ +G K + +S S + + + D T K+W + Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 Query: 1117 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162 L GH C+ + + +G ++ + IWN+ E++ Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294 Score = 57.0 bits (136), Expect = 1e-07 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%) Query: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1142 H V S S + +S+SADK KIW ++D + GH + A+S DS LL Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102 Query: 1143 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1200 + D+ ++IW+VS+G+ L + H +V F+P +++S ++ Sbjct: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 Query: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1246 W+V TG+ +T + + +H + D V+ G+ I T Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 123 bits (309), Expect = 1e-27 Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D + Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+ Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793 +C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213 Query: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 849 + + +S +G I+ A N + L+D ++ G + +TGH + +YC +FS Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267 Query: 850 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 906 +V+ S+ V +WN ++ V +GH V P + +++ +D+TI Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 Query: 907 RLWET 911 +LW++ Sbjct: 328 KLWKS 332 Score = 103 bits (258), Expect = 8e-22 Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203 Query: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792 +C T+ N V+ +FSP+ K + + + D TLKLWD + K+ Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253 Query: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 850 E ++S G + +V+ N ++++++ T ++ ++ I Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 Query: 851 QNHLAVVAL-SQYCVELWNTD 870 +N +A AL + ++LW +D Sbjct: 313 ENIIASAALENDKTIKLWKSD 333 Score = 93.6 bits (231), Expect = 1e-18 Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%) Query: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712 + H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+ Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 Query: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772 LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 Query: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 831 + K++ DP V ++ DG+ I+ ++ + + ++D + Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 Query: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 889 L + + + + FSP + A ++LW+ + GH + + + Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 Query: 890 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 940 FS G ++ S S+D + +W +TK++ + L+ DVV EN + A+ Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321 Query: 941 DHIRRLQL 948 ++ + ++L Sbjct: 322 ENDKTIKL 329 Score = 86.3 bits (212), Expect = 2e-16 Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%) Query: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797 T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92 Query: 798 EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 857 +WS+D ++ A+ +K +SG + GH + + C+F+PQ++L V Sbjct: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 Query: 858 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 917 V +W+ + + H V V F+ DGS ++SS D R+W+T Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201 Query: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977 S LK +D +N VS SP+ +YI Sbjct: 202 SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230 Query: 978 FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1034 + +++ + + ++ HK + I F+ K ++S S+D + +WN Q Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 Query: 1035 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1070 + + L+GH + V +++ + D T+K+W Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 Score = 80.1 bits (196), Expect = 1e-14 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%) Query: 1040 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1098 L GH + V + N L S S D +K+W G EK H+ + S D+ Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 Query: 1099 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158 S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 Query: 1159 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1212 G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T Sbjct: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208 Score = 73.2 bits (178), Expect = 1e-12 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%) Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670 ++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184 Query: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242 Query: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771 ++ +C T GH N +C F+ K + S S D + +W+ Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 Score = 70.1 bits (170), Expect = 1e-11 Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + FSP + + +++W GH + V +S D + Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 Query: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957 +++SDD+T+++W+ V + L+ + G + Sbjct: 103 VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131 Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 V CC +P I G + ++ I ++ + ++ H V + F D Sbjct: 132 ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185 Query: 1018 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074 ++SSS D ++W+ +C+ + V + N + +L+ + D T+K+W+ Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1131 G K + H+ + T S S D IW+ + +L+GH V Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305 Query: 1132 CSAFSVDSTLLATG--DDNGEIRIW 1154 +A ++A+ +++ I++W Sbjct: 306 STACHPTENIIASAALENDKTIKLW 330 Score = 61.6 bits (148), Expect = 4e-09 Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 GH V V FSP+G +SS D+ I++W D F++ Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82 Query: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 I+G + +S S + ++ ++I ++ + + ++ Sbjct: 83 ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 Query: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1058 H V+ F ++S S D +++W+ + KC+ L H + V ++ L Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185 Query: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1116 + S S+DG ++W+ +G K + +S S + + + D T K+W + Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 Query: 1117 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162 L GH C+ + + +G ++ + IWN+ E++ Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294 Score = 57.0 bits (136), Expect = 1e-07 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%) Query: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1142 H V S S + +S+SADK KIW ++D + GH + A+S DS LL Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102 Query: 1143 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1200 + D+ ++IW+VS+G+ L + H +V F+P +++S ++ Sbjct: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 Query: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1246 W+V TG+ +T + + +H + D V+ G+ I T Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 120 bits (300), Expect = 1e-26 Identities = 79/298 (26%), Positives = 133/298 (44%), Gaps = 18/298 (6%) Query: 614 HTDAVYHACFSED-GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 672 H + VY F+ G +IA+ DKT +++ ETG+ + H E++C +F+ + Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192 Query: 673 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732 AT S+D K+W+ GE V+T HS ++ F S ++ TGS D + +WD + Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADT 250 Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792 N + GH ++ F+ D L+ + S D T KLWDAT+ ++ Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---------- 300 Query: 793 PQEDMEVIVKCCSWSADGARIMVA-AKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 851 D E++ C ++ G I A A +F T + ++ GH I F+PQ Sbjct: 301 -GHDDEILDSCFDYT--GKLIATASADGTARIFSAATRKCIAKLE-GHEGEISKISFNPQ 356 Query: 852 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 909 + + S +W+ + + GH + F+ G+ +T S D T R+W Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 110 bits (275), Expect = 8e-24 Identities = 78/305 (25%), Positives = 139/305 (45%), Gaps = 18/305 (5%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTD- 668 V++ H + + ++ G + D+T +++ +GE+L ++ H + V AF+ Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146 Query: 669 -DRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727 D+ IAT S DK K+W+ TG+ HT+ H+ ++ C F S L+ATGS D KL Sbjct: 147 GDK-IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS--TLVATGSMDTTAKL 203 Query: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 787 WD+ E T+ GH+ + F+ + + S D T+ +WDA + + +N+ Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG---RKVNILIGH 260 Query: 788 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCD 847 + S++ D + I+ + +K T+G TGH I Sbjct: 261 C----------AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310 Query: 848 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 907 F L A + +++ +R +A GH + + F+P G+ LT S D+T R Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370 Query: 908 LWETK 912 +W+ + Sbjct: 371 IWDAQ 375 Score = 92.4 bits (228), Expect = 2e-18 Identities = 66/257 (25%), Positives = 118/257 (45%), Gaps = 17/257 (6%) Query: 612 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 671 R HT + F+ +A+ D T +++ + GE++ ++ H E++ +F+T Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233 Query: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731 I T S D V +W++ TG V+ H +++ F L+ TGS D KLWD Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--LILTGSMDKTCKLWDAT 291 Query: 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 791 +C T+ GH + + F KL+A+ SADGT +++ SA RK I LE Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---SAATRKCI------AKLE 342 Query: 792 DPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSP 850 + ++ I S++ G ++ + +K ++D T L ++ GH I C F+ Sbjct: 343 GHEGEISKI----SFNPQGNHLLTGSSDKTARIWDAQTGQCL-QVLEGHTDEIFSCAFNY 397 Query: 851 QNHLAVVALSQYCVELW 867 + ++ + +W Sbjct: 398 KGNIVITGSKDNTCRIW 414 Score = 77.8 bits (190), Expect = 6e-14 Identities = 66/310 (21%), Positives = 120/310 (38%), Gaps = 40/310 (12%) Query: 865 ELWNTDSRSKVADCRGHLSWVHGVMFS-PDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 923 +LW+T S ++ GH + V+ + F+ P G T S D+T +LW Sbjct: 117 KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW-------------- 162 Query: 924 QEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENG 983 +V+ + G T A++ C +P +A G + Sbjct: 163 ---------------SVETGKCYHTFRGHT--------AEIVCLSFNPQSTLVATGSMDT 199 Query: 984 AIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRG 1042 ++ ++ N + H + + F +I+ S D + VW+ + + L G Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259 Query: 1043 HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1101 H + + S +L+ S D T K+W+ G H +L + + Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319 Query: 1102 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1161 + SAD TA+I+S + +L GH G + +F+ L TG + RIW+ G+ Sbjct: 320 TASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC 379 Query: 1162 LHLCAPLSEE 1171 L + ++E Sbjct: 380 LQVLEGHTDE 389 Score = 58.9 bits (141), Expect = 3e-08 Identities = 40/182 (21%), Positives = 80/182 (43%), Gaps = 7/182 (3%) Query: 995 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKD--FR 1051 +F+ H + ++ I+ S D ++W+ ++ L GH+ V F Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 1052 LLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKI 1111 ++ + SFD T K+W++ TG F H ++ + +T ++ S D TAK+ Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203 Query: 1112 WSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL----CAP 1167 W ++ LRGH+ + +F+ + TG + + +W+ G +++ CA Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263 Query: 1168 LS 1169 +S Sbjct: 264 IS 265 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 117 bits (293), Expect = 7e-26 Identities = 85/303 (28%), Positives = 152/303 (50%), Gaps = 23/303 (7%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 HT+AV FS +G+ +AS AD+ + ++ A G+ + H E+ A+S+D + Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S DK +K+W+ +G+ + T HS V CC+F S+ L+ +GS D +K+W++ Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN--LIISGSFDETVKIWEVKTG 157 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793 +C T+ H++ V+ F+ L+ S S DG ++WDA S K++ Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL------------ 205 Query: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 849 +D V +S +G I+ A N + L+D ++ G + +TGH + +YC +FS Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD-YSRGRCLKTYTGHKNE-KYCIFANFS 263 Query: 850 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 906 +V+ S+ V +WN ++ V +GH V P + +++ +D+TI Sbjct: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTI 323 Query: 907 RLW 909 +LW Sbjct: 324 KLW 326 Score = 82.4 bits (202), Expect = 2e-15 Identities = 80/341 (23%), Positives = 146/341 (42%), Gaps = 58/341 (17%) Query: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797 T+ GHT +V+ +FSP+ + LAS SAD + +W A K++ + NLE Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL----YGHNLE------ 85 Query: 798 EVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 856 + +WS+D +R++ A+ +K + L+D+ + L + GH + + C+F+P ++L + Sbjct: 86 ---ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLII 141 Query: 857 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 916 V++W + + H V V F+ GS ++ S D R+W+ Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA---- 197 Query: 917 NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 976 S LK VD +N VS SP+ +YI Sbjct: 198 -SGQCLKTLVD---DDN----------------------------PPVSFVKFSPNGKYI 225 Query: 977 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQ 1033 + +++ + R ++ HK + I F+ K ++S S+D + +WN Q Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 285 Query: 1034 LDKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1070 + + L+GH + V L++ + D T+K+W Sbjct: 286 TKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326 Score = 80.9 bits (198), Expect = 7e-15 Identities = 73/280 (26%), Positives = 127/280 (45%), Gaps = 24/280 (8%) Query: 982 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW---NWQLDKCI 1038 N + E+ E N + + H + V ++F+ + + L SSS D I +W + + +K + Sbjct: 20 NQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL 79 Query: 1039 FLRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1097 + GH + D +SRL+S S D T+K+W++ +G K H V C+ + + Sbjct: 80 Y--GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137 Query: 1098 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1157 S S D+T KIW L L H+ V F+ +L+ +G +G RIW+ + Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197 Query: 1158 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYT 1215 +G+ L V+ + FSP+GK +++A +K W+ G +T+ Sbjct: 198 SGQCLKTLVDDDNPP-------VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY-- 248 Query: 1216 NGTNLKKIHVSPDFK-------TYVTVDNLGILYILQTLE 1248 G +K + +F + DNL ++ LQT E Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288 Score = 71.6 bits (174), Expect = 4e-12 Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 8/166 (4%) Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670 ++ H++ V+ F+ I S D+T+++++ +TG+ L + AH D V F+ Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180 Query: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAT--LDNTLKLWD 238 Query: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771 ++ C T GH N +C F+ K + S S D + +W+ Sbjct: 239 YSRGRCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 283 Score = 68.2 bits (165), Expect = 5e-11 Identities = 62/325 (19%), Positives = 120/325 (36%), Gaps = 45/325 (13%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + FSP + + + +W GH + V +S D S Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98 Query: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957 +++SDD+T++LW+ +R + + G + Sbjct: 99 VSASDDKTLKLWD--------------------------------VRSGKCLKTLKGHSN 126 Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 Y V CC +P I G + ++I E+ + ++ H V + F Sbjct: 127 Y-----VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181 Query: 1018 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074 ++S S D ++W+ +C+ + V + N + +L+ + D T+K+W+ Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1131 G K + H+ + T S S D IW+ + +L+GH V Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 301 Query: 1132 CSAFSVDSTLLATG--DDNGEIRIW 1154 +A L+A+ +++ I++W Sbjct: 302 SAACHPTENLIASAALENDKTIKLW 326 Score = 68.2 bits (165), Expect = 5e-11 Identities = 56/208 (26%), Positives = 95/208 (45%), Gaps = 8/208 (3%) Query: 960 TEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 1019 TEA VS SP+ +++A + I I + + ++ + H + + +++D L+ Sbjct: 41 TEA-VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99 Query: 1020 SSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL-LSWSFDGTVKVWNIITGNK 1077 S+SDD +++W+ + KC+ L+GH V S L +S SFD TVK+W + TG Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159 Query: 1078 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGHNGCVRCSA 1134 K H V + + + S S D +IW S L L + N V Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL--VDDDNPPVSFVK 217 Query: 1135 FSVDSTLLATGDDNGEIRIWNVSNGELL 1162 FS + + T + +++W+ S G L Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCL 245 Score = 60.5 bits (145), Expect = 1e-08 Identities = 54/289 (18%), Positives = 106/289 (36%), Gaps = 43/289 (14%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 GH V V FSP+G +SS D+ I +W Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGA---------------------------- 70 Query: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 +G+ + Y ++S S + ++ +++ ++ + + ++ Sbjct: 71 ---------YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121 Query: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRL-LKNSR 1057 H V+ F +IS S D +++W + KC+ L H + V S Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181 Query: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1116 ++S S+DG ++W+ +G K V +S S + + + D T K+W + Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241 Query: 1117 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162 L GH C+ + + +G ++ + IWN+ E++ Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290 Score = 45.8 bits (107), Expect = 3e-04 Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 7/114 (6%) Query: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLC--CAFS-TDDRFIATCSVDK 679 FS +G+ I + D TL+++ G L H++E C FS T ++I + S D Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277 Query: 680 KVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLWDLN 731 V IWN T E+V H++ V CH T + + A +D +KLW N Sbjct: 278 LVYIWNLQTKEIVQKLQGHTDVVISAACHPTENL--IASAALENDKTIKLWMSN 329 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 108 bits (271), Expect = 2e-23 Identities = 72/300 (24%), Positives = 128/300 (42%), Gaps = 41/300 (13%) Query: 613 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 672 P T ++H FS + S D T++V+ ETG+ +K H D V +F + + Sbjct: 110 PVTRVIFHPVFSV----MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165 Query: 673 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732 A+CS D +K+W+ E + T H V+ + H++ A S D +K+W++ Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA--SRDKTIKMWEVQT 223 Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792 C T GH V R + D L+ASCS D T+++W + + + Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL----------- 272 Query: 793 PQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN 852 + E +V+C SW+ + + ++ + SG G Sbjct: 273 --REHEHVVECISWAPESSYSSISEATG---SETKKSGKPGP------------------ 309 Query: 853 HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 912 + +++W+ + + GH +WV GV+F G L+ +DD+T+R+W+ K Sbjct: 310 -FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368 Score = 86.7 bits (213), Expect = 1e-16 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 18/197 (9%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H V +G I S DKT+++++ +TG + H + V + D IA Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL------------------L 715 +CS D+ V++W T E EH V C + S + Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310 Query: 716 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775 L +GS D +K+WD++ C T+ GH N V F K + SC+ D TL++WD + Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370 Query: 776 NERKSINVKQFFLNLED 792 K++N + F+ D Sbjct: 371 RCMKTLNAHEHFVTSLD 387 Score = 81.6 bits (200), Expect = 4e-15 Identities = 66/302 (21%), Positives = 126/302 (41%), Gaps = 37/302 (12%) Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670 ++ HTD+V F G+ +ASC AD T++++ + E + + H+ V A + Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD 205 Query: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730 I + S DK +K+W TG V T+ H E V + L+A+ S+D +++W + Sbjct: 206 HIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVV 263 Query: 731 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790 KEC+ + H + V ++P+ + + +AT + +KS F L+ Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSS---------ISEATGSETKKSGKPGPFLLS- 313 Query: 791 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 850 G+R I ++D+ T L + GH + ++ F Sbjct: 314 -------------------GSR-----DKTIKMWDVSTGMCLMTL-VGHDNWVRGVLFHS 348 Query: 851 QNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910 + + +W+ ++ + H +V + F +T S DQT+++WE Sbjct: 349 GGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Query: 911 TK 912 + Sbjct: 409 CR 410 Score = 80.5 bits (197), Expect = 9e-15 Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 30/246 (12%) Query: 971 PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1030 P + E+ I++ + ++ H +V I F K L S S D I++W Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177 Query: 1031 NWQLDKCI-FLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1088 ++Q +CI + GH V ++ N ++S S D T+K+W + TG K F H+ V Sbjct: 178 DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWV 237 Query: 1089 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-------- 1140 + D T +S S D+T ++W ELR H V C +++ +S+ Sbjct: 238 RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEAT 297 Query: 1141 ------------LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPD 1188 L +G + I++W+VS G L H WV + F Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT--------LVGHDNWVRGVLFHSG 349 Query: 1189 GKMLIS 1194 GK ++S Sbjct: 350 GKFILS 355 Score = 69.3 bits (168), Expect = 2e-11 Identities = 47/161 (29%), Positives = 78/161 (48%), Gaps = 2/161 (1%) Query: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLLKNSRLL- 1059 H+ V + F ++S+S+DA I+VW+++ D L+GH ++V+D + +LL Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166 Query: 1060 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1119 S S D T+K+W+ + H V S I + S S DKT K+W Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226 Query: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1160 + GH VR + D TL+A+ ++ +R+W V+ E Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267 Score = 67.8 bits (164), Expect = 6e-11 Identities = 71/341 (20%), Positives = 123/341 (36%), Gaps = 61/341 (17%) Query: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 896 +GH S + F P + V A +++W+ ++ +GH V + F G Sbjct: 105 SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKL 164 Query: 897 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 956 + S D TI+LW+ FQ E + H Sbjct: 165 LASCSADMTIKLWD-------------------FQGFECIRTMHGH-------------- 191 Query: 957 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1016 + VS + P+ +I + I++ E+ ++ H++ V ++ D Sbjct: 192 ----DHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGT 247 Query: 1017 TLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSR------------------ 1057 + S S+D ++VW +C LR H+ V+ S Sbjct: 248 LIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKP 307 Query: 1058 ---LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSAD-KTAKIWS 1113 LLS S D T+K+W++ TG V H V + H KF + AD KT ++W Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV-LFHSGGKFILSCADDKTLRVWD 366 Query: 1114 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154 + + L H V F + + TG + +++W Sbjct: 367 YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 Score = 58.9 bits (141), Expect = 3e-08 Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 10/155 (6%) Query: 1056 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1115 S ++S S D T+KVW+ TG+ E+ H +V H +S SAD T K+W F Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180 Query: 1116 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1175 + + GH+ V A + + + + I++W V G + + Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV--------KTFTG 232 Query: 1176 HGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGE 1208 H WV + + DG ++ S ++ W V T E Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267 Score = 57.8 bits (138), Expect = 6e-08 Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 61/302 (20%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 GH S V V+F P S +++S+D TI++W+ + + LK D V ++ Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET--GDFERTLKGHTD------SVQDIS 157 Query: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 DH +L +A + I++ + ++ Sbjct: 158 FDHSGKL-----------------------------LASCSADMTIKLWDFQGFECIRTM 188 Query: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1058 H V + + ++S+S D I++W Q C+ GH+E V+ R ++ L Sbjct: 189 HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL 248 Query: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC-------------DISHDATKFS--- 1101 + S S D TV+VW + T + + H+ V+ C + + TK S Sbjct: 249 IASCSNDQTVRVWVVATKECKAELREHEH-VVECISWAPESSYSSISEATGSETKKSGKP 307 Query: 1102 -----STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV 1156 S S DKT K+W + L L GH+ VR F + + D+ +R+W+ Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367 Query: 1157 SN 1158 N Sbjct: 368 KN 369 Score = 44.7 bits (104), Expect = 6e-04 Identities = 25/81 (30%), Positives = 39/81 (48%) Query: 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC 663 T + + + H + V F G+ I SC DKTL+V+ + + + AHE V Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386 Query: 664 AFSTDDRFIATCSVDKKVKIW 684 F ++ T SVD+ VK+W Sbjct: 387 DFHKTAPYVVTGSVDQTVKVW 407 Score = 35.8 bits (81), Expect = 0.26 Identities = 25/110 (22%), Positives = 46/110 (41%), Gaps = 10/110 (9%) Query: 1121 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1180 + L GH V F +++ + ++ I++W+ G+ E H V Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF--------ERTLKGHTDSV 153 Query: 1181 TDLCFSPDGKML--ISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1228 D+ F GK+L SA IK W+ E +T + + N+ + + P+ Sbjct: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203 >gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] Length = 631 Score = 105 bits (263), Expect = 2e-22 Identities = 87/316 (27%), Positives = 131/316 (41%), Gaps = 37/316 (11%) Query: 601 KNITNLSRLVV-----RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKA 655 KNI L L V +PH D + SCG D+ +V LL Sbjct: 345 KNIFRLHELPVSCVSMQPHKDI------------LVSCGEDRLWKVLGLPKCNVLLTGFG 392 Query: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715 H D + C F +AT S D VK+W+ G+ + T++ HS V C + + + Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN--F 450 Query: 716 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775 +A+ S D K+WD+N + CR T++GHT+SVN F P L + SAD TL +WDA + Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510 Query: 776 NERKSINVKQFFLN--LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 833 +S+ +N + DP+ M C + L+D + Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK--------------LWDFRKLLPIV 556 Query: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 893 I G S +F + A + L + S ++ GH + H V+FS D Sbjct: 557 SIDIG-PSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS-GEIHKLMGHENEAHTVVFSHD 614 Query: 894 GSSFLTSSDDQTIRLW 909 G + D T+R W Sbjct: 615 GEILFSGGSDGTVRTW 630 Score = 72.4 bits (176), Expect = 3e-12 Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%) Query: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977 S V ++ D++ E + V + + ++ G D+L++ CC P +A Sbjct: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410 Query: 978 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 1037 + +++ +L + H + VW + + + SSS D ++W+ ++C Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470 Query: 1038 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1095 L GH ++V S LL+ S D T+ +W+ TG E+ H ++ Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530 Query: 1096 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155 +S A K+W F LLP+ + F +LA NG I + + Sbjct: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590 Query: 1156 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1203 + +GE+ L H + FS DG++L S G G ++ W+ Sbjct: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631 Score = 59.7 bits (143), Expect = 2e-08 Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 16/208 (7%) Query: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNS-R 1057 H+ V + + L+S +D +V L KC L GH + + D + + Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLG--LPKCNVLLTGFGHTDWLSDCCFHPSGDK 408 Query: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117 L + S D TVK+W++ G+ F H V SC +S+S DKT+KIW + Sbjct: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468 Query: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1177 L GH V F S L T + + IW+ G + E+ H Sbjct: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--------ICEQSLYGHM 520 Query: 1178 GWVTDLCFSPDGKMLIS--AGGYIKWWN 1203 + D F P G M+ S A G K W+ Sbjct: 521 HSINDAIFDPRGHMIASCDACGVTKLWD 548 Score = 58.9 bits (141), Expect = 3e-08 Identities = 47/199 (23%), Positives = 80/199 (40%), Gaps = 2/199 (1%) Query: 959 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1018 L E VSC + PH + E+ ++L L + + F H + F L Sbjct: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKL 409 Query: 1019 ISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGN 1076 +SS D +++W+ CI GH V + + S S D T K+W++ + Sbjct: 410 ATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER 469 Query: 1077 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1136 H +V S + + ++SADKT IW + L GH + + F Sbjct: 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529 Query: 1137 VDSTLLATGDDNGEIRIWN 1155 ++A+ D G ++W+ Sbjct: 530 PRGHMIASCDACGVTKLWD 548 Score = 58.5 bits (140), Expect = 4e-08 Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 44/280 (15%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 GH W+ F P G TSS D T++LW+ +CK ++ + Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD---LCKGDCILTFE--------------- 433 Query: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 H R V C ++A + +I ++ + R + Sbjct: 434 -GHSR------------------AVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474 Query: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSRL 1058 + H +V I+F TL++SS D + +W+ + C L GH ++ D + Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHM 534 Query: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDATKFSSTSADKTAKIWSFDL 1116 + S G K+W+ K V G +++ D++ A I DL Sbjct: 535 IASCDACGVTKLWDF---RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591 Query: 1117 LL-PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155 +H+L GH FS D +L +G +G +R W+ Sbjct: 592 KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631 Score = 48.5 bits (114), Expect = 4e-05 Identities = 41/206 (19%), Positives = 79/206 (38%), Gaps = 20/206 (9%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + C + + + ++W+ +S GH V+ + F P ++ Sbjct: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493 Query: 898 LTSSDDQTIRLWETKK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQ 955 LTSS D+T+ +W+ + +C+ S + D +F M+ + D G T Sbjct: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKL 546 Query: 956 IDYLTEAQVSCCCLSPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKT 1005 D+ + + P + +A NG I +L+L + I H+ Sbjct: 547 WDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENE 605 Query: 1006 VWHIQFTADEKTLISSSDDAEIQVWN 1031 + F+ D + L S D ++ W+ Sbjct: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631 Score = 35.0 bits (79), Expect = 0.45 Identities = 47/240 (19%), Positives = 87/240 (36%), Gaps = 6/240 (2%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + C F P + V+LW+ + GH V + G+ Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451 Query: 898 LTSSDDQTIRLWE-TKKVCKNSAVMLKQEVD-VVFQENEVMVLAVDHIRRLQLINGRTG- 954 +SS D+T ++W+ + C+ + V+ + F +L + L + + RTG Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511 Query: 955 --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 1012 Q Y ++ P IA D G ++ + S + F Sbjct: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571 Query: 1013 ADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWN 1071 + + L +S + I + + + + L GH+ + +L S DGTV+ W+ Sbjct: 572 SSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631 >gi|21536371 telomerase-associated protein 1 [Homo sapiens] Length = 2627 Score = 105 bits (262), Expect = 3e-22 Identities = 181/793 (22%), Positives = 310/793 (39%), Gaps = 108/793 (13%) Query: 487 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 539 L YH+ + L + +L + A EL + L+ Y L E D A Sbjct: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604 Query: 540 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 599 V F+ FL +L + P + Q +P S + QA L +++ + L W+N Sbjct: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658 Query: 600 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654 K KN + S L V AV FS +GQR A A+ T+ + T ++ + Sbjct: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715 Query: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714 + D + C F +DD T + D +++W+ G V H Q+ C + Sbjct: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772 Query: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 772 LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ + Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829 Query: 773 TSANERKSI-----NVKQFFLNLED---PQEDMEVIVKCCSWSADGARIMVAAKNKIFL- 823 K + +++ N+ ++ +V+ +W +GAR+ + F+ Sbjct: 1830 DGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWR-EGARLAAFPAHHGFVA 1888 Query: 824 --FDIHTSGLLGEIHTGHHSTIQYCDFS---PQNHLAVVALSQYCVELWNTDSRSKVADC 878 +H L + G +Q S P+ HL ++LS + D Sbjct: 1889 AALFLHAGCQL--LTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGY 1946 Query: 879 RGHLSWVHGVMFSPDGSS------------------FLTSSDDQTIRLWETKKVCKNSAV 920 R ++ + G+ ++ ++D +++ W K+ S Sbjct: 1947 RADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLW 2006 Query: 921 ML----KQEVDVVFQENEVMVLAVDHIRRL---QLINGRTGQIDYLT-------EAQVSC 966 +L K + + + + + D +L QL+ D+ E VSC Sbjct: 2007 LLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSC 2066 Query: 967 CCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHIQFTADEKTLISSS 1022 C S +A G + ++ ++ + I H+ V +T D LIS S Sbjct: 2067 CSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCS 2125 Query: 1023 DDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080 D + +W+ + + + FL GHQ V ++ ++S S DGT+KVW+ G + Sbjct: 2126 SDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTLKVWDH-QGVELTS 2182 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLLPLHELRGHNGCVR 1131 H G + C + + + D ++W L+ H L GH+G VR Sbjct: 2183 IPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242 Query: 1132 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1191 +A S S L+ T ++G +R+W V E C P S VT + ++PDG M Sbjct: 2243 AAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA-------VTAVAWAPDGSM 2294 Query: 1192 LIS---AGGYIKW 1201 +S AG I W Sbjct: 2295 AVSGNQAGELILW 2307 Score = 59.3 bits (142), Expect = 2e-08 Identities = 103/508 (20%), Positives = 177/508 (34%), Gaps = 76/508 (14%) Query: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 776 A G+++ + L DL + ++ + ++ C F DD L + + DG L+LWD Sbjct: 1692 AVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGC 1750 Query: 777 ERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH 836 Q+ I CC V + L+D G L H Sbjct: 1751 RVLQTKAHQY------------QITGCCLSPDCRLLATVCLGGCLKLWDT-VRGQLAFQH 1797 Query: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 896 T + ++ F P+ + + + D D + + + F+ G Sbjct: 1798 T-YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856 Query: 897 FLTSSDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTG 954 D + LW ++ + +A +F +L ++Q+ +G G Sbjct: 1857 VAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLG 1916 Query: 955 Q----IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010 + + L+ + LSP +A G I I + +++ ++ Q Sbjct: 1917 RPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYK-ISSGSQGAQGQALDVAVSAL 1975 Query: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1070 K L+S ++D +Q W L +C L++ LLS Sbjct: 1976 AWLSPKVLVSGAEDGSLQ--GWALKECS--------------LQSLWLLSR--------- 2010 Query: 1071 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLH--------- 1121 Q VL S + +S S D T ++W LL H Sbjct: 2011 -------------FQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPHKAEDFPCGT 2055 Query: 1122 ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1181 ELRGH G V C +FS D LATG + + W+V + L A H WVT Sbjct: 2056 ELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLIHSFPACHRDWVT 2111 Query: 1182 DLCFSPDGKML-ISAGGYIKWWNVVTGE 1208 ++ D ++ S+ G + W+ +G+ Sbjct: 2112 GCAWTKDNLLISCSSDGSVGLWDPESGQ 2139 Score = 48.9 bits (115), Expect = 3e-05 Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 14/158 (8%) Query: 628 QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR---------FIATCSVD 678 + + S D TL+V+ + G +L I AH + CA + + R + T +D Sbjct: 2159 EHVVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217 Query: 679 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 738 ++W+ + HT HS V + +S L+ T S D ++LW + KE +T Sbjct: 2218 GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG--LMLTASEDGSVRLWQV-PKEADDT 2274 Query: 739 MFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSA 775 ++ +V ++PD + S + G L LW A Sbjct: 2275 CIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKA 2312 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 104 bits (260), Expect = 5e-22 Identities = 75/294 (25%), Positives = 122/294 (41%), Gaps = 13/294 (4%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H V + FS DGQ + + D + ++ +G+ L + H V C FS D A Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S D V++W+ + + H V F+ S LA+G D + LWD+ Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ--LASGGWDKRVMLWDVQSG 137 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793 + + GH +S+ FSP LA+ S D T+ +WD S Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVS----------HQA 187 Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNH 853 E + C +SA G + I ++ TS LL ++ GH + ++ FSP Sbjct: 188 LEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQL-KGHVTWVKSIAFSPDEL 246 Query: 854 LAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 907 A V++W+ ++ + +G L H F+PDG ++ + DQT R Sbjct: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300 Score = 98.6 bits (244), Expect = 3e-20 Identities = 74/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%) Query: 963 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 1022 +V+ SP Q + G E+G + E + ++ H V +F+ D S+S Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82 Query: 1023 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1080 D +++W+ KC+ L+GHQ +V+ +SR L S +D V +W++ +G + Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL---HELRGHNGCVRCSAFSV 1137 V H+ ++ S D S ++ S D T IW ++ P L GH+ + C +S Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202 Query: 1138 DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG- 1196 S LLA+G + I IW + LL + +G T WV + FSPD L SAG Sbjct: 203 -SGLLASGSWDKTIHIWKPTTSSLL-----IQLKGHVT---WVKSIAFSPDELWLASAGY 253 Query: 1197 -GYIKWWNVVTGESSQT 1212 +K W+ TG+ +T Sbjct: 254 SRMVKVWDCNTGKCLET 270 Score = 82.8 bits (203), Expect = 2e-15 Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 53/320 (16%) Query: 881 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 940 H V+ FSPDG LT S+D + WET+ Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-------------------------- 53 Query: 941 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 1000 + L + G TG + + C SP A + + + ++ + + Sbjct: 54 ---QLLWRLGGHTGPVKF--------CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLK 102 Query: 1001 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVK--DFRLLKNSR 1057 H+++V + F+ D + L S D + +W+ Q + + L GH+++++ DF N Sbjct: 103 GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC- 161 Query: 1058 LLSWSFDGTVKVWNI--ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1115 L + S+D TV +W++ +T + +SC + +S S DKT IW Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221 Query: 1116 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1175 L +L+GH V+ AFS D LA+ + +++W+ + G+ L + + Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD----- 276 Query: 1176 HGGWVTDLC-FSPDGKMLIS 1194 V C F+PDGK+L+S Sbjct: 277 ----VAHTCAFTPDGKILVS 292 Score = 76.6 bits (187), Expect = 1e-13 Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 6/168 (3%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V++ H +V FS D +++AS G DK + ++ ++G+ L + H D + FS Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159 Query: 670 RFIATCSVDKKVKIWN--SMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 726 +AT S D V IW+ +T + H + HS ++C ++ S LLA+GS D + Sbjct: 160 NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTIH 216 Query: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 774 +W + GH V FSPD+ LAS +K+WD + Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264 Score = 72.4 bits (176), Expect = 3e-12 Identities = 62/233 (26%), Positives = 101/233 (43%), Gaps = 12/233 (5%) Query: 1001 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL 1059 QH V F+ D + L++ S+D + W + + ++ L GH VK R + L Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78 Query: 1060 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1118 S S D TV++W++ + HQ +V + S D+ + +S DK +W Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138 Query: 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1178 L L GH ++ S FS LATG + + IW +L + +S + H Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW-----DLRMVTPAVSHQALEGHSA 193 Query: 1179 WVTDLCFSPDGKMLISAGGY---IKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1228 ++ LC+S G L+++G + I W T + T +K I SPD Sbjct: 194 NISCLCYSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244 Score = 71.2 bits (173), Expect = 6e-12 Identities = 64/311 (20%), Positives = 113/311 (36%), Gaps = 41/311 (13%) Query: 839 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 898 H + FSP + + CV W T S + GH V FSPDG F Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79 Query: 899 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 958 ++S D T+RLW+ V + L+++ G Sbjct: 80 SASCDCTVRLWD-----------------------------VARAKCLRVLKGH------ 104 Query: 959 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1018 + V SP + +A G + + + ++ + ++ + H+ ++ F+ L Sbjct: 105 --QRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCL 162 Query: 1019 ISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1074 + S D+ + +W+ ++ L GH + + L S S+D T+ +W T Sbjct: 163 ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTT 222 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1134 + H V S S D +S + K+W + L L+G A Sbjct: 223 SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCA 282 Query: 1135 FSVDSTLLATG 1145 F+ D +L +G Sbjct: 283 FTPDGKILVSG 293 Score = 62.4 bits (150), Expect = 3e-09 Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 21/252 (8%) Query: 801 VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859 V ++S DG ++ +++ ++ ++ + LL + GH +++C FSP HL A Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGHLFASAS 82 Query: 860 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSA 919 V LW+ + +GH V V FSPD + D+ + LW+ + S Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ-----SG 137 Query: 920 VMLK---------QEVDVVFQENEVMVLAVD---HIRRLQLINGRTG-QIDYLTEAQVSC 966 ML+ Q D N + + D HI L+++ Q A +SC Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197 Query: 967 CCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAE 1026 C S +A G + I I + + + H V I F+ DE L S+ Sbjct: 198 LCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256 Query: 1027 IQVWNWQLDKCI 1038 ++VW+ KC+ Sbjct: 257 VKVWDCNTGKCL 268 Score = 58.2 bits (139), Expect = 5e-08 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 3/117 (2%) Query: 606 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAF 665 +S + H+ + C+S G +AS DKT+ ++K T L+++K H V AF Sbjct: 183 VSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF 241 Query: 666 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 722 S D+ ++A+ + VK+W+ TG+ + T + + C FT +L +G++D Sbjct: 242 SPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK--ILVSGAAD 296 Score = 47.8 bits (112), Expect = 7e-05 Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 10/158 (6%) Query: 1079 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1138 K F H G V S S D + S D W L L GH G V+ FS D Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74 Query: 1139 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG-- 1196 L A+ + +R+W+V+ + L + H V + FSPD + L S G Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRV--------LKGHQRSVETVSFSPDSRQLASGGWD 126 Query: 1197 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234 + W+V +G+ + + +++ SP T Sbjct: 127 KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164 Score = 35.4 bits (80), Expect = 0.34 Identities = 21/79 (26%), Positives = 38/79 (48%) Query: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660 K T+ + ++ H V FS D +AS G + ++V+ TG+ L +K D Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278 Query: 661 LCCAFSTDDRFIATCSVDK 679 CAF+ D + + + + D+ Sbjct: 279 HTCAFTPDGKILVSGAADQ 297 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 103 bits (258), Expect = 8e-22 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%) Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 Y TE ++ +SP + +A G +N I++ L + ++ H+ V I D Sbjct: 265 YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319 Query: 1018 LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1076 ++ DD + + LRGH V R L +S LLS S D +++ W++ + Sbjct: 320 ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375 Query: 1077 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1136 + H V DIS + F+S S D+TA++WSFD PL GH V C F Sbjct: 376 NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435 Query: 1137 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196 +S LATG + +R+W+ G + L H G V L FSP+GK L SAG Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487 Query: 1197 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1228 +K W++ +G + + N+ + SPD Sbjct: 488 EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521 Score = 79.3 bits (194), Expect = 2e-14 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H V+ S AS D+T +++ + L H +V C F + ++A Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 T S DK V++W++ G V + H V F+ + +L A+ D LKLWDL Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 + GHT+++ FSPD L+AS S D ++++WD Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538 Score = 77.0 bits (188), Expect = 1e-13 Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 26/263 (9%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 ++R H VY F D + SC D +++ + + + + H V S Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 + A+ S D+ ++W+ + Y H V+C F +S++L ATGS+D ++LW Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789 Q GH V FSP+ K LAS D LKLWD S + Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---------LYKE 505 Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIH----------TSGLLGEIHTG 838 L ++ + ++S D I A+ N + ++DI +S L ++TG Sbjct: 506 LRGHTDN----ITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561 Query: 839 HHSTIQYCDFSPQNHLAVVALSQ 861 S + F N L V ++Q Sbjct: 562 QMSNVLSVQFMACNLLLVTGITQ 584 Score = 73.9 bits (180), Expect = 9e-13 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%) Query: 891 SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 944 SPD D+ I+LW + S + D++ +E++ A ++ Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336 Query: 945 RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 1003 L+ G +L ++ + C ++Y G N ++Q H Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384 Query: 1004 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1060 VW + + S S D ++W++ D+ LR GH V + NS L+ Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442 Query: 1061 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1119 S D TV++W+ GN + F H+G VLS S + +S D+ K+W Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502 Query: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158 ELRGH + FS DS L+A+ + +R+W++ N Sbjct: 503 YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541 Score = 70.9 bits (172), Expect = 7e-12 Identities = 68/309 (22%), Positives = 111/309 (35%), Gaps = 59/309 (19%) Query: 647 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 706 G ++ ++ H V F D + +CS D ++ W+ + Y H+ V Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389 Query: 707 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 766 S + L A+GS D +LW ++ GH V+ +F P+ LA+ S D T Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449 Query: 767 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDI 826 ++LW A N + LF Sbjct: 450 VRLWSAQQG-------------------------------------------NSVRLF-- 464 Query: 827 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVH 886 TGH + FSP A ++LW+ S + + RGH + Sbjct: 465 ----------TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514 Query: 887 GVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIR- 944 + FSPD ++S D ++R+W+ + C A E+ V+ VL+V + Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMAC 574 Query: 945 RLQLINGRT 953 L L+ G T Sbjct: 575 NLLLVTGIT 583 Score = 67.4 bits (163), Expect = 8e-11 Identities = 68/322 (21%), Positives = 125/322 (38%), Gaps = 56/322 (17%) Query: 735 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA---NERKSINVKQF----- 786 C + +N SPD KLLA+ + +KLW S +E ++V + Sbjct: 260 CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319 Query: 787 FLNLEDPQED-----MEVIVKCCS------WSADGARIMVAAKNKIFLFDIHTSGLLGEI 835 L ED ++D M+++ C + AD + ++ +++ + S + Sbjct: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379 Query: 836 HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 895 + GH + D SP + LW+ D + GHL+ V V F P+ + Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439 Query: 896 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 955 T S D+T+RLW + Q N V +L G G Sbjct: 440 YLATGSTDKTVRLWSAQ------------------QGNSV-----------RLFTGHRGP 470 Query: 956 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1015 + L SP+ +Y+A E+ +++ +L + +++ H + + F+ D Sbjct: 471 VLSLA--------FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS 522 Query: 1016 KTLISSSDDAEIQVWNWQLDKC 1037 + S+S D ++VW+ + C Sbjct: 523 GLIASASMDNSVRVWDIRNTYC 544 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 102 bits (254), Expect = 2e-21 Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V++ H D V C G RI S D TL+V+ A TG+ L + H V D Sbjct: 257 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 313 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 369 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789 + +C + + GH +V ++ D + + S + D +K+WD + ++ Q N Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 424 Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 848 + S DG ++ + I ++D+ T + + TGH S + Sbjct: 425 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 471 Query: 849 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 905 ++++ V + V++W+ + + +G H S V + F+ + +TSSDD T Sbjct: 472 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 527 Query: 906 IRLWETK 912 ++LW+ K Sbjct: 528 VKLWDLK 534 Score = 85.1 bits (209), Expect = 4e-16 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%) Query: 894 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 951 G+ ++ SDD T+++W T K + ++N ++ + D R L++ N Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 330 Query: 952 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010 TG+ + S C+ H + + G + + + ++ + H V +Q Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 390 Query: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1069 + D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V Sbjct: 391 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 447 Query: 1070 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1126 W++ TGN HQ ++ + S +AD T KIW L L+G H Sbjct: 448 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505 Query: 1127 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173 V C F+ + T D+G +++W++ GE + L G+ Sbjct: 506 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 550 Score = 80.9 bits (198), Expect = 7e-15 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%) Query: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1035 I G ++ +++ V + ++ H VW Q + +IS S D ++VWN + Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 333 Query: 1036 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1094 +CI L GH TV+ L R++S S D T++VW+I TG + H V + Sbjct: 334 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 390 Query: 1095 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154 +D + S + D K+W + LH L+GH R + D + +G + IR+W Sbjct: 391 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 448 Query: 1155 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1179 +V G +H +G H Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508 Query: 1180 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1215 VT L F+ + + S G +K W++ TGE + T Sbjct: 509 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 544 Score = 71.6 bits (174), Expect = 4e-12 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%) Query: 1031 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1087 NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G Sbjct: 246 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305 Query: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147 V S + + S S D+T K+W+ + +H L GH VRC + + +G Sbjct: 306 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 361 Query: 1148 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1204 + +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+ Sbjct: 362 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 410 Query: 1205 VT 1206 T Sbjct: 411 ET 412 Score = 39.7 bits (91), Expect = 0.018 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%) Query: 630 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686 + S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+ Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533 Query: 687 MTGELV 692 TGE + Sbjct: 534 KTGEFI 539 Score = 32.3 bits (72), Expect = 2.9 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%) Query: 1123 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1181 L+GH+ + C F + +G D+ +++W+ G+ L T G W + Sbjct: 258 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 309 Query: 1182 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1225 + ++IS +K WN TGE T Y + + ++ +H+ Sbjct: 310 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 102 bits (254), Expect = 2e-21 Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V++ H D V C G RI S D TL+V+ A TG+ L + H V D Sbjct: 375 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 431 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 487 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789 + +C + + GH +V ++ D + + S + D +K+WD + ++ Q N Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 542 Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 848 + S DG ++ + I ++D+ T + + TGH S + Sbjct: 543 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 589 Query: 849 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 905 ++++ V + V++W+ + + +G H S V + F+ + +TSSDD T Sbjct: 590 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 645 Query: 906 IRLWETK 912 ++LW+ K Sbjct: 646 VKLWDLK 652 Score = 85.1 bits (209), Expect = 4e-16 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%) Query: 894 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 951 G+ ++ SDD T+++W T K + ++N ++ + D R L++ N Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 448 Query: 952 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010 TG+ + S C+ H + + G + + + ++ + H V +Q Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 508 Query: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1069 + D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V Sbjct: 509 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 565 Query: 1070 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1126 W++ TGN HQ ++ + S +AD T KIW L L+G H Sbjct: 566 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623 Query: 1127 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173 V C F+ + T D+G +++W++ GE + L G+ Sbjct: 624 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 668 Score = 80.9 bits (198), Expect = 7e-15 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%) Query: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1035 I G ++ +++ V + ++ H VW Q + +IS S D ++VWN + Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 451 Query: 1036 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1094 +CI L GH TV+ L R++S S D T++VW+I TG + H V + Sbjct: 452 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 508 Query: 1095 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154 +D + S + D K+W + LH L+GH R + D + +G + IR+W Sbjct: 509 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 566 Query: 1155 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1179 +V G +H +G H Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626 Query: 1180 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1215 VT L F+ + + S G +K W++ TGE + T Sbjct: 627 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 662 Score = 71.6 bits (174), Expect = 4e-12 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%) Query: 1031 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1087 NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G Sbjct: 364 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423 Query: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147 V S + + S S D+T K+W+ + +H L GH VRC + + +G Sbjct: 424 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 479 Query: 1148 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1204 + +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+ Sbjct: 480 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 528 Query: 1205 VT 1206 T Sbjct: 529 ET 530 Score = 39.7 bits (91), Expect = 0.018 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%) Query: 630 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686 + S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+ Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651 Query: 687 MTGELV 692 TGE + Sbjct: 652 KTGEFI 657 Score = 32.3 bits (72), Expect = 2.9 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%) Query: 1123 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1181 L+GH+ + C F + +G D+ +++W+ G+ L T G W + Sbjct: 376 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 427 Query: 1182 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1225 + ++IS +K WN TGE T Y + + ++ +H+ Sbjct: 428 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 102 bits (254), Expect = 2e-21 Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V++ H D V C G RI S D TL+V+ A TG+ L + H V D Sbjct: 295 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 351 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 407 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789 + +C + + GH +V ++ D + + S + D +K+WD + ++ Q N Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 462 Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 848 + S DG ++ + I ++D+ T + + TGH S + Sbjct: 463 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 509 Query: 849 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 905 ++++ V + V++W+ + + +G H S V + F+ + +TSSDD T Sbjct: 510 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 565 Query: 906 IRLWETK 912 ++LW+ K Sbjct: 566 VKLWDLK 572 Score = 85.1 bits (209), Expect = 4e-16 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%) Query: 894 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 951 G+ ++ SDD T+++W T K + ++N ++ + D R L++ N Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 368 Query: 952 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010 TG+ + S C+ H + + G + + + ++ + H V +Q Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 428 Query: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1069 + D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V Sbjct: 429 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 485 Query: 1070 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1126 W++ TGN HQ ++ + S +AD T KIW L L+G H Sbjct: 486 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543 Query: 1127 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173 V C F+ + T D+G +++W++ GE + L G+ Sbjct: 544 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 588 Score = 80.9 bits (198), Expect = 7e-15 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%) Query: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1035 I G ++ +++ V + ++ H VW Q + +IS S D ++VWN + Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 371 Query: 1036 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1094 +CI L GH TV+ L R++S S D T++VW+I TG + H V + Sbjct: 372 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 428 Query: 1095 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154 +D + S + D K+W + LH L+GH R + D + +G + IR+W Sbjct: 429 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 486 Query: 1155 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1179 +V G +H +G H Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546 Query: 1180 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1215 VT L F+ + + S G +K W++ TGE + T Sbjct: 547 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 582 Score = 71.6 bits (174), Expect = 4e-12 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%) Query: 1031 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1087 NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G Sbjct: 284 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343 Query: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147 V S + + S S D+T K+W+ + +H L GH VRC + + +G Sbjct: 344 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 399 Query: 1148 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1204 + +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+ Sbjct: 400 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 448 Query: 1205 VT 1206 T Sbjct: 449 ET 450 Score = 39.7 bits (91), Expect = 0.018 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%) Query: 630 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686 + S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+ Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571 Query: 687 MTGELV 692 TGE + Sbjct: 572 KTGEFI 577 Score = 32.3 bits (72), Expect = 2.9 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%) Query: 1123 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1181 L+GH+ + C F + +G D+ +++W+ G+ L T G W + Sbjct: 296 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 347 Query: 1182 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1225 + ++IS +K WN TGE T Y + + ++ +H+ Sbjct: 348 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 101 bits (251), Expect = 5e-21 Identities = 69/252 (27%), Positives = 128/252 (50%), Gaps = 11/252 (4%) Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 669 ++ H+ AV ++ DG + S DKT+ V+ +ETGE++ +K H V C Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 + + T S D VK+W+ + T+ +++ QV F ++S ++ +G D +K+WD Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789 L Q + TM GH +SV S + L S + D T+++WD ++ VK F N Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280 Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDF 848 + + ++++ CSWS DG++I + ++ ++++D + +L ++ GH +I F Sbjct: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGHAGSINEVAF 335 Query: 849 SPQNHLAVVALS 860 P + + A S Sbjct: 336 HPDEPIIISASS 347 Score = 91.3 bits (225), Expect = 5e-18 Identities = 76/323 (23%), Positives = 135/323 (41%), Gaps = 48/323 (14%) Query: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNT-DSRSKVADCRGHLSWVHGVMFSPDGS 895 +GH + C F P A + LWN A +GH V + ++ DGS Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGS 122 Query: 896 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 955 ++S D+T+ +W+++ R++ + G T Sbjct: 123 MLFSASTDKTVAVWDSETG-----------------------------ERVKRLKGHTSF 153 Query: 956 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1015 ++ SC Q + G ++G +++ ++ Q+ FQ+ V + F Sbjct: 154 VN-------SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTS 205 Query: 1016 KTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNII 1073 +IS D +I+VW+ + +K + +RGH ++V L + S LLS + D TV+VW++ Sbjct: 206 DQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265 Query: 1074 T-GNKEKDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG 1125 KE+ QG V L C S D +K ++ SAD+ +W L++L G Sbjct: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325 Query: 1126 HNGCVRCSAFSVDSTLLATGDDN 1148 H G + AF D ++ + + Sbjct: 326 HAGSINEVAFHPDEPIIISASSD 348 Score = 75.9 bits (185), Expect = 2e-13 Identities = 72/332 (21%), Positives = 129/332 (38%), Gaps = 47/332 (14%) Query: 698 HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN--TMFGHTNSVNHCRFSPDD 755 H +V CC F + LA+ D + LW++ +C N T+ GH+ +V ++ D Sbjct: 65 HEGEVYCCKFHPNGS--TLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTDG 121 Query: 756 KLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 815 +L S S D T+ +WD+ + K + F+N P +V C+ S DG Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV--CTGSDDGT---- 175 Query: 816 AAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV 875 + L+DI + + + F+ + + +++W+ Sbjct: 176 -----VKLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT 228 Query: 876 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 935 RGH V G+ S +GS L+++ D T+R+W+ + K+ +FQ N Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCVKIFQGNV- 281 Query: 936 MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 995 + E + C SP IA G + + + + + RI Sbjct: 282 ----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI 319 Query: 996 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 1027 H ++ + F DE +IS+S D + Sbjct: 320 LYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 74.3 bits (181), Expect = 7e-13 Identities = 69/313 (22%), Positives = 118/313 (37%), Gaps = 68/313 (21%) Query: 650 LLEIKAHEDEVLCCAF-------------------------------------------S 666 ++ + HE EV CC F + Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118 Query: 667 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 726 TD + + S DK V +W+S TGE V H+ VN C+ L+ TGS D +K Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ-LVCTGSDDGTVK 177 Query: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 786 LWD+ +K T F +T V F+ + S D +K+WD + + Sbjct: 178 LWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD---------LRQNKL 227 Query: 787 FLNLEDPQEDMEVIVKCCSWSADGARIMV-AAKNKIFLFDIHTSG--------LLGEIHT 837 + + V S S++G+ ++ A N + ++D+ G +H Sbjct: 228 TYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283 Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 + ++ C +SP + V +W+T SR + GH ++ V F PD Sbjct: 284 FEKNLLR-CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPII 342 Query: 898 LTSSDDQTIRLWE 910 +++S D+ + + E Sbjct: 343 ISASSDKRLYMGE 355 Score = 62.4 bits (150), Expect = 3e-09 Identities = 43/185 (23%), Positives = 85/185 (45%), Gaps = 11/185 (5%) Query: 589 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 648 D+G + L I KK + + +T V F++ +I S G D ++V+ + Sbjct: 172 DDGTVKLWDIRKK-----AAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226 Query: 649 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN----SMTGELVHTY--DEHSEQV 702 ++ H D V + S++ ++ + ++D V++W+ + V + + H+ + Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286 Query: 703 NCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 762 N + S +A GS+D F+ +WD + + GH S+N F PD+ ++ S S Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS 346 Query: 763 ADGTL 767 +D L Sbjct: 347 SDKRL 351 Score = 58.9 bits (141), Expect = 3e-08 Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%) Query: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 1019 E +V CC P+ +A + I + + + + + H V + + D L Sbjct: 66 EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125 Query: 1020 SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1076 S+S D + VW+ + + + L+GH V + L + S DGTVK+W+I Sbjct: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182 Query: 1077 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1134 K+ Q T VL+ + + + S D K+W + +RGH V + Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242 Query: 1135 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1193 S + + L + + +R+W+V C + + + +SPDG + Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302 Query: 1194 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1243 SA ++ W+ + + ++ ++ PD ++ + LY+ Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 38.1 bits (87), Expect = 0.053 Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%) Query: 1116 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1175 L P+ L GH G V C F + + LA+ + I +WNV C + AT Sbjct: 55 LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104 Query: 1176 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1208 H G V +L ++ DG ML SA + W+ TGE Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 100 bits (250), Expect = 7e-21 Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%) Query: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1059 H+ V + F+ + K L S S D+ + VW+ + + GH++ V + LL Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77 Query: 1060 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1119 S S D TV++W + F H TV S D F + S DKT K+W+ Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137 Query: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1179 L L H VRC+ FS D L+ + D+ +++W+ S+ E +H HGG+ Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189 Query: 1180 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1237 VT + F P G + +AG +K W+V T Q + + + + P +T + Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249 Query: 1238 LGILYILQTLE 1248 L IL +E Sbjct: 250 DSTLKILDLME 260 Score = 99.8 bits (247), Expect = 1e-20 Identities = 65/255 (25%), Positives = 115/255 (45%), Gaps = 15/255 (5%) Query: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713 K H D V C FS + + +A+ S+D + +W+ + + H + V C +F+ S H Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74 Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773 LLA+GS D +++W N K HT +V F D + + S D T+K+W Sbjct: 75 -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130 Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 833 + + ++F +L V+C +S DG I+ A+ +K +S Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180 Query: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 893 + H + Y DF P A V++W+ + + + H + V+G+ F P Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240 Query: 894 GSSFLTSSDDQTIRL 908 G+ +T+S D T+++ Sbjct: 241 GNYLITASSDSTLKI 255 Score = 98.6 bits (244), Expect = 3e-20 Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 19/300 (6%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H DAV FS + +++AS D L V+ + + H+D V C FS +A Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77 Query: 674 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732 + S DK V+IW ++ GE + H+ V HF + + T S D +K+W ++ Sbjct: 78 SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134 Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792 ++ ++ H N V +FSPD +L+ S S D T+KLWD +S S F+ D Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194 Query: 793 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 851 + G I A N + ++D+ T LL + + H + + F P Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPS 240 Query: 852 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911 + + A S +++ + + GH V FS G F + D+ + +W++ Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300 Score = 90.1 bits (222), Expect = 1e-17 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V R HT V F DGQ + DKT++V+ + L + H + V C FS D Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 + H+ +VN F P L + S+D TLK+ D Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257 Score = 79.0 bits (193), Expect = 3e-14 Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 46/338 (13%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + DFS C+ +W+ +S+ GH V V FSP G Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76 Query: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957 + S D+T+R+W +K E VF+ + V +V Sbjct: 77 ASGSRDKTVRIWVPN---------VKGE-STVFRAHTATVRSVH---------------- 110 Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 + ++ Q ++ D+ +++ + S QH V +F+ D + Sbjct: 111 FCSDGQ----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159 Query: 1018 LISSSDDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1074 ++S+SDD +++W+ +C+ G T DF + + + D TVKVW++ T Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 218 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1134 + + H V + S+D T KI L+ L GH G A Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278 Query: 1135 FSVDSTLLATGDDNGEIRIWN-----VSNGELLHLCAP 1167 FS A+G + ++ +W V +GE+ + P Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316 Score = 79.0 bits (193), Expect = 3e-14 Identities = 67/300 (22%), Positives = 123/300 (41%), Gaps = 18/300 (6%) Query: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800 GH ++V FS + K LAS S D L +W K + F +D Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63 Query: 801 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 860 V C ++S G + +++K + + H +T++ F V A Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123 Query: 861 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 919 V++W T + + H++WV FSPDG +++SDD+T++LW+ + + C +S Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183 Query: 920 VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 975 V V F + + A +++ + RT ++ L A V+ P Y Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243 Query: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1035 + + ++IL+L+ R+ + H+ + F+ + S D ++ VW D Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303 Score = 74.7 bits (182), Expect = 5e-13 Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%) Query: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 896 TGH + +FSP HL V +W + + + R H + V V F DG S Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117 Query: 897 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 956 F+T+SDD+T+++W T + + L Q ++ Sbjct: 118 FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 146 Query: 957 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1016 V C SP + I ++ +++ + + S +H V ++ F Sbjct: 147 ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200 Query: 1017 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074 + ++ D ++VW+ + + + + H V + L++ S D T+K+ +++ Sbjct: 201 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1117 G HQG + S F+S +D+ +W +FD++ Sbjct: 261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305 Score = 71.2 bits (173), Expect = 6e-12 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%) Query: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1022 V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122 Query: 1023 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1080 DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ + Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 + H G V D T ++ D T K+W L + H+ V +F Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196 L T + ++I ++ G LL+ H G T + FS G+ S G Sbjct: 243 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290 Score = 50.4 bits (119), Expect = 1e-05 Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%) Query: 1078 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1137 E+ F H+ V D S + + +S S D +W + GH V C FS Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71 Query: 1138 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1171 LLA+G + +RIW + + +H C+ S++ Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131 Query: 1172 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1217 + H WV FSPDG++++SA +K W+ + E ++ +G Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 100 bits (250), Expect = 7e-21 Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%) Query: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1059 H+ V + F+ + K L S S D+ + VW+ + + GH++ V + LL Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77 Query: 1060 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1119 S S D TV++W + F H TV S D F + S DKT K+W+ Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137 Query: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1179 L L H VRC+ FS D L+ + D+ +++W+ S+ E +H HGG+ Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189 Query: 1180 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1237 VT + F P G + +AG +K W+V T Q + + + + P +T + Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249 Query: 1238 LGILYILQTLE 1248 L IL +E Sbjct: 250 DSTLKILDLME 260 Score = 99.8 bits (247), Expect = 1e-20 Identities = 65/255 (25%), Positives = 115/255 (45%), Gaps = 15/255 (5%) Query: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713 K H D V C FS + + +A+ S+D + +W+ + + H + V C +F+ S H Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74 Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773 LLA+GS D +++W N K HT +V F D + + S D T+K+W Sbjct: 75 -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130 Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 833 + + ++F +L V+C +S DG I+ A+ +K +S Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180 Query: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 893 + H + Y DF P A V++W+ + + + H + V+G+ F P Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240 Query: 894 GSSFLTSSDDQTIRL 908 G+ +T+S D T+++ Sbjct: 241 GNYLITASSDSTLKI 255 Score = 98.6 bits (244), Expect = 3e-20 Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 19/300 (6%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H DAV FS + +++AS D L V+ + + H+D V C FS +A Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77 Query: 674 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 732 + S DK V+IW ++ GE + H+ V HF + + T S D +K+W ++ Sbjct: 78 SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134 Query: 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792 ++ ++ H N V +FSPD +L+ S S D T+KLWD +S S F+ D Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194 Query: 793 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 851 + G I A N + ++D+ T LL + + H + + F P Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPS 240 Query: 852 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911 + + A S +++ + + GH V FS G F + D+ + +W++ Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300 Score = 90.1 bits (222), Expect = 1e-17 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V R HT V F DGQ + DKT++V+ + L + H + V C FS D Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 + H+ +VN F P L + S+D TLK+ D Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257 Score = 79.0 bits (193), Expect = 3e-14 Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 46/338 (13%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + DFS C+ +W+ +S+ GH V V FSP G Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76 Query: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957 + S D+T+R+W +K E VF+ + V +V Sbjct: 77 ASGSRDKTVRIWVPN---------VKGE-STVFRAHTATVRSVH---------------- 110 Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 + ++ Q ++ D+ +++ + S QH V +F+ D + Sbjct: 111 FCSDGQ----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159 Query: 1018 LISSSDDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1074 ++S+SDD +++W+ +C+ G T DF + + + D TVKVW++ T Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 218 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1134 + + H V + S+D T KI L+ L GH G A Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278 Query: 1135 FSVDSTLLATGDDNGEIRIWN-----VSNGELLHLCAP 1167 FS A+G + ++ +W V +GE+ + P Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316 Score = 79.0 bits (193), Expect = 3e-14 Identities = 67/300 (22%), Positives = 123/300 (41%), Gaps = 18/300 (6%) Query: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800 GH ++V FS + K LAS S D L +W K + F +D Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63 Query: 801 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 860 V C ++S G + +++K + + H +T++ F V A Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123 Query: 861 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 919 V++W T + + H++WV FSPDG +++SDD+T++LW+ + + C +S Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183 Query: 920 VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 975 V V F + + A +++ + RT ++ L A V+ P Y Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243 Query: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1035 + + ++IL+L+ R+ + H+ + F+ + S D ++ VW D Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303 Score = 74.7 bits (182), Expect = 5e-13 Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%) Query: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 896 TGH + +FSP HL V +W + + + R H + V V F DG S Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117 Query: 897 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 956 F+T+SDD+T+++W T + + L Q ++ Sbjct: 118 FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 146 Query: 957 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1016 V C SP + I ++ +++ + + S +H V ++ F Sbjct: 147 ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200 Query: 1017 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074 + ++ D ++VW+ + + + + H V + L++ S D T+K+ +++ Sbjct: 201 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1117 G HQG + S F+S +D+ +W +FD++ Sbjct: 261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305 Score = 71.2 bits (173), Expect = 6e-12 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%) Query: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1022 V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122 Query: 1023 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1080 DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ + Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 + H G V D T ++ D T K+W L + H+ V +F Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196 L T + ++I ++ G LL+ H G T + FS G+ S G Sbjct: 243 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290 Score = 50.4 bits (119), Expect = 1e-05 Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%) Query: 1078 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1137 E+ F H+ V D S + + +S S D +W + GH V C FS Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71 Query: 1138 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1171 LLA+G + +RIW + + +H C+ S++ Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131 Query: 1172 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1217 + H WV FSPDG++++SA +K W+ + E ++ +G Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187 >gi|148727341 serine/threonine kinase receptor associated protein [Homo sapiens] Length = 350 Score = 100 bits (249), Expect = 9e-21 Identities = 79/303 (26%), Positives = 134/303 (44%), Gaps = 26/303 (8%) Query: 614 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670 HT V FS G + S D + + +TG+ + H+ V + D Sbjct: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72 Query: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730 AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL Sbjct: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129 Query: 731 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789 N+ E + GHT+ + + +DK + S D T++LWD + E KS+N + Sbjct: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188 Query: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH-STIQYCDF 848 +E E I+V + F H++ L I + +TI Sbjct: 189 MEYIPE---------------GEILVITYGRSIAF--HSAVSLDPIKSFEAPATINSASL 231 Query: 849 SPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 908 P+ V + + ++ +S ++ +GH +H V FSPDG + + S+D T+RL Sbjct: 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRL 291 Query: 909 WET 911 W+T Sbjct: 292 WQT 294 Score = 48.9 bits (115), Expect = 3e-05 Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%) Query: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1114 L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S Sbjct: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91 Query: 1115 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1160 D L+ L H V+ F+ DS L TG + +RI++++ E Sbjct: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133 Score = 48.1 bits (113), Expect = 5e-05 Identities = 57/330 (17%), Positives = 116/330 (35%), Gaps = 49/330 (14%) Query: 836 HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 895 HT + + +P + + A L D+ + GH V G + D + Sbjct: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72 Query: 896 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 955 T++ D T ++W+ +E+M LA HI + Sbjct: 73 KAATAAADFTAKVWDA------------------VSGDELMTLAHKHIVKT--------- 105 Query: 956 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQ 1010 +D+ ++ Y+ G ++ + I +L KK +W Sbjct: 106 VDFTQDSN-----------YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW--- 151 Query: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1070 E I S+DD +++W+ + +V + +L ++ ++ Sbjct: 152 --CSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFH 209 Query: 1071 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCV 1130 + ++ + K F T+ S + + + D + ++ L +GH G + Sbjct: 210 SAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPI 268 Query: 1131 RCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1160 C FS D L A+G ++G +R+W G+ Sbjct: 269 HCVRFSPDGELYASGSEDGTLRLWQTVVGK 298 Score = 35.8 bits (81), Expect = 0.26 Identities = 17/57 (29%), Positives = 28/57 (49%) Query: 634 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 690 G D L + +GE+L K H + C FS D A+ S D +++W ++ G+ Sbjct: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298 Score = 35.0 bits (79), Expect = 0.45 Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%) Query: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1060 HK VW D +++ D +VW+ + H+ VK ++S LL+ Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117 Query: 1061 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1120 D ++++++ E + + + + K ++ DKT ++W + + Sbjct: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177 Query: 1121 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1180 L S S++ GEI + H L + + Sbjct: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226 Query: 1181 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1238 P+ + L++ G K ++ +GE +++ + + + SPD + Y + Sbjct: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286 Query: 1239 GILYILQTL 1247 G L + QT+ Sbjct: 287 GTLRLWQTV 295 Score = 34.3 bits (77), Expect = 0.76 Identities = 50/293 (17%), Positives = 119/293 (40%), Gaps = 31/293 (10%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + + A A + + ++W+ S ++ H V V F+ D + Sbjct: 57 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYL 115 Query: 898 LTSSDDQTIRLW-------ETKKVCKNSAVMLK----QEVDVVFQENEVMVLAVDHIRRL 946 LT D+ +R++ E K++ +++ + K E + ++ V DH Sbjct: 116 LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMT 175 Query: 947 QL----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 1002 ++ N ++Y+ E ++ + + + IAF + A+ + + + F+ Sbjct: 176 EVKSLNFNMSVSSMEYIPEGEI---LVITYGRSIAF---HSAVSLDPIKS-------FEA 222 Query: 1003 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLLKNSRLL-S 1060 T+ +++ L++ +D ++ +++ ++ +GH + R + L S Sbjct: 223 PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYAS 282 Query: 1061 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113 S DGT+++W + G + C S +++ F T+ ++ +I S Sbjct: 283 GSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIAS 335 >gi|102470001 PQQ repeat and WD repeat domain containing [Homo sapiens] Length = 472 Score = 99.8 bits (247), Expect = 1e-20 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%) Query: 587 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 646 +VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ + Sbjct: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261 Query: 647 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 699 LL I KAH + + C F+ F+ T S DK +KIWN TGE V H Sbjct: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321 Query: 700 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 759 V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K + Sbjct: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379 Query: 760 SCSADGTLKLWDATSANE 777 S S D T++LW+ +E Sbjct: 380 SASKDRTMRLWNIEEIDE 397 Score = 86.3 bits (212), Expect = 2e-16 Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%) Query: 595 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654 L W ++ ++ + ++ H AV F D ++ S D T++++ G + + + Sbjct: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141 Query: 655 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713 + V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ + Sbjct: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200 Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773 ++ + N HT S+ C F PD + +AS S D +K+WD T Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260 Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 829 S +I + I CC ++ G + ++ +K + ++++HT Sbjct: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308 Query: 830 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 887 G + GH ++ C F+ + + V +W+ + +GH WV Sbjct: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368 Query: 888 VMFSPDGSSFLTSSDDQTIRLWETKKV 914 V S + L++S D+T+RLW +++ Sbjct: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395 Score = 71.6 bits (174), Expect = 4e-12 Identities = 70/306 (22%), Positives = 132/306 (43%), Gaps = 32/306 (10%) Query: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGH-LSWVHGVMFSP 892 +I +GH + C F + + V+LW+ S V D + V + Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155 Query: 893 DGSSFLTSSDDQTIRLW--ETKKV------------CKNSAVMLKQEVDVVFQENEVMVL 938 D S + +S D+T+R W ET K+ CK S K V ++ + ++ Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDG-KYVVSGFDVDHGICIM 214 Query: 939 AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 998 ++I + +I D+ T + ++ CC P Q +A + I+I ++ + + Sbjct: 215 DAENITTVSVIK------DHHTRS-ITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLT 267 Query: 999 RFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK------CIFL-RGHQETVKDF 1050 + H + + FT L +SS D +++WN + C+ L +GH+ +V Sbjct: 268 ITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSC 327 Query: 1051 RLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109 ++S L+S FD TV +W++ G ++ H V+ IS++ S S D+T Sbjct: 328 HFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTM 387 Query: 1110 KIWSFD 1115 ++W+ + Sbjct: 388 RLWNIE 393 Score = 60.5 bits (145), Expect = 1e-08 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%) Query: 1040 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1097 L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+ Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157 Query: 1098 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1156 ++ + S DKT + W + L ++R V C FS D + +G D + I I + Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216 Query: 1157 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1206 N + + H +T CF PD + + +S IK W+V + Sbjct: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261 Score = 59.3 bits (142), Expect = 2e-08 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 936 GH V F D + L+ S D T++LW+ V ++ K V + + Sbjct: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159 Query: 937 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 992 V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219 Query: 993 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1050 + + H +++ F D + + S S D I++W+ Q + H + + Sbjct: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279 Query: 1051 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109 + L + S+D +K+WN+ TG +F + A T Sbjct: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316 Query: 1110 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1169 ++GH G V F+ DS+ L +G + + IW+V+ G LS Sbjct: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358 Query: 1170 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1204 +G H WV D+ S + K ++SA ++ WN+ Sbjct: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392 >gi|26665869 WD repeat domain 51B [Homo sapiens] Length = 478 Score = 99.4 bits (246), Expect = 2e-20 Identities = 71/299 (23%), Positives = 129/299 (43%), Gaps = 17/299 (5%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H A+ S +G+++A+ D L ++ + + H+D V FS +A Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + S D+ V++W + H+ V F S+ LAT S D +K+W + ++ Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF--SADGQFLATASEDKSIKVWSMYRQ 134 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793 +++ HT+ V +FSPD +L+ SCS D T+K+WD T+ + + F N D Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD- 193 Query: 794 QEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN 852 ++ G I A ++ + ++D+ + LL + + H + F P Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLL-QHYQVHSGGVNCISFHPSG 240 Query: 853 HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911 + + A S +++ + + +GH V V FS G F + D + LW T Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299 Score = 92.4 bits (228), Expect = 2e-18 Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 12/251 (4%) Query: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR-GHQETVKDFRLLKNSRLL- 1059 HK + + + + K L ++S D + +WN++ + GH++ V + + LL Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76 Query: 1060 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1119 S S D TV++W K +F H V S D S D ++ S DK+ K+WS Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136 Query: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1179 L+ L H VRC+ FS D L+ + ++ I+IW+ +N + ++ + G+ Sbjct: 137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN--------NFSDSVGF 188 Query: 1180 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1237 + F+P G + SAG +K W+V + Q + + + I P +T + Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248 Query: 1238 LGILYILQTLE 1248 G L IL LE Sbjct: 249 DGTLKILDLLE 259 Score = 90.1 bits (222), Expect = 1e-17 Identities = 69/322 (21%), Positives = 128/322 (39%), Gaps = 52/322 (16%) Query: 716 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775 LAT S D FL LW+ GH + V +FSP LLAS S D T++LW Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR 92 Query: 776 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGE 834 + V+ +SADG + A+++K I ++ ++ L Sbjct: 93 GKFSEFKAH-------------TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139 Query: 835 IHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDG 894 ++ H ++ FSP L V +++W+T ++ V + + + + V F+P G Sbjct: 140 LYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG 198 Query: 895 SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG 954 + ++ DQT+++W+ + V+ + Q +V Sbjct: 199 TCIASAGSDQTVKVWDVR-------------VNKLLQHYQV------------------- 226 Query: 955 QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD 1014 V+C P Y+ +G ++IL+L+ R+ + H V+ + F+ Sbjct: 227 -----HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKG 281 Query: 1015 EKTLISSSDDAEIQVWNWQLDK 1036 + S D ++ +W D+ Sbjct: 282 GELFASGGADTQVLLWRTNFDE 303 Score = 88.6 bits (218), Expect = 3e-17 Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Query: 612 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 671 + HT V FS DGQ +A+ DK+++V+ L + H V C FS D R Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158 Query: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731 I +CS DK +KIW++ + V+ + + N F S +A+ SD +K+WD+ Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG--TCIASAGSDQTVKVWDVR 216 Query: 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 + H+ VN F P L + S+DGTLK+ D Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256 Score = 84.3 bits (207), Expect = 6e-16 Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 50/350 (14%) Query: 879 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVL 938 +GH + + + SP+G T+S D + LW K Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK-------------------------- 48 Query: 939 AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 998 H R + + G D +T Q SPH +A + + + F Sbjct: 49 --PHARAYRYV----GHKDVVTSVQ-----FSPHGNLLASASRDRTVRLWIPDKRGKFSE 97 Query: 999 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1057 H V + F+AD + L ++S+D I+VW+ + ++ L H V+ + + R Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157 Query: 1058 LL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1116 L+ S S D T+K+W+ +F G D + T +S +D+T K+W + Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217 Query: 1117 LLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATH 1176 L + H+G V C +F L T +G ++I ++ G L++ H Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT--------LQGH 269 Query: 1177 GGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIH 1224 G V + FS G++ S G + W E T NLK++H Sbjct: 270 TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTK-RNLKRLH 318 Score = 77.4 bits (189), Expect = 8e-14 Identities = 64/265 (24%), Positives = 114/265 (43%), Gaps = 17/265 (6%) Query: 646 TGEKLLE--IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 703 T + +LE K H+ + S + + +AT S D + +WN + Y H + V Sbjct: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64 Query: 704 CCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSA 763 F S H LLA+ S D ++LW +++ + HT V FS D + LA+ S Sbjct: 65 SVQF--SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122 Query: 764 DGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL 823 D ++K+W S+ ++F +L V+C +S DG I+ +++K Sbjct: 123 DKSIKVW---------SMYRQRFLYSLYRHTH----WVRCAKFSPDGRLIVSCSEDKTIK 169 Query: 824 FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLS 883 T+ + + DF+P A S V++W+ + + H Sbjct: 170 IWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229 Query: 884 WVHGVMFSPDGSSFLTSSDDQTIRL 908 V+ + F P G+ +T+S D T+++ Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254 Score = 57.4 bits (137), Expect = 8e-08 Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 2/112 (1%) Query: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682 F+ G IAS G+D+T++V+ + L + H V C +F ++ T S D +K Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253 Query: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 734 I + + G L++T H+ V F+ L A+G +D + LW N E Sbjct: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGE--LFASGGADTQVLLWRTNFDE 303 Score = 45.4 bits (106), Expect = 3e-04 Identities = 38/180 (21%), Positives = 62/180 (34%), Gaps = 52/180 (28%) Query: 1078 EKDFVCHQGTVLSCDISHDATK-------------------------------------- 1099 E+ F H+ + S D+S + + Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70 Query: 1100 ----FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155 +S S D+T ++W D E + H VR FS D LAT ++ I++W+ Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130 Query: 1156 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1213 + L+ H WV FSPDG++++S IK W+ + F Sbjct: 131 MYRQRFLY--------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182 Score = 36.2 bits (82), Expect = 0.20 Identities = 23/101 (22%), Positives = 39/101 (38%), Gaps = 1/101 (0%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H+ V F G + + +D TL++ G + ++ H V +FS A Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714 + D +V +W + EL H + HF + H L Sbjct: 287 SGGADTQVLLWRTNFDEL-HCKGLTKRNLKRLHFDSPPHLL 326 >gi|5803221 WD repeat-containing protein 3 [Homo sapiens] Length = 943 Score = 95.9 bits (237), Expect = 2e-19 Identities = 136/672 (20%), Positives = 250/672 (37%), Gaps = 124/672 (18%) Query: 622 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 681 C S DG +A D ++++F +GE + H+ + + +A+ S D + Sbjct: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131 Query: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741 +W+ + ++ H + + F + LL T D +K WDL+ + C TM G Sbjct: 132 IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189 Query: 742 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 801 H V ++K L + ++D L++WD E +EDP+E + Sbjct: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237 Query: 802 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ 861 K S+ G + + A++ F D +P++ + + Sbjct: 238 K---GSSPGIQDTLEAEDGAF----------------------ETDEAPEDRILSCRKAG 272 Query: 862 YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 921 + + D G + HG + L+ + Q ++ + K + A + Sbjct: 273 SIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKL 331 Query: 922 LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-F 978 + + E V + D I+R+ I T A++ L SPH + A F Sbjct: 332 HSSKGEEEDPEVNVEMSLQDEIQRVTNIK---------TSAKIKSFDLIHSPHGELKAVF 382 Query: 979 GDENGAIEILEL-----VNNRIFQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVW 1030 +N +E+ L + SR H+ V + F++D ++S++ D+ I++W Sbjct: 383 LLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIW 441 Query: 1031 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1090 N +CI + + F + + +++ + G ++++++ +GN + H G + S Sbjct: 442 NRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWS 501 Query: 1091 CDISHDATKFSSTSADKTAKIWSFDLL-----------------LPLHE----------- 1122 +S D F + ADK+ K W F+L+ L L E Sbjct: 502 MSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQ 561 Query: 1123 -------------------------LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1157 L GH V C S D L+ATG + ++IW + Sbjct: 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD 621 Query: 1158 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYT 1215 G+ + H V L F P + +AG IK W+ E QT Sbjct: 622 FGD--------CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673 Query: 1216 NGTNLKKIHVSP 1227 + + + VSP Sbjct: 674 HHQEIWCLAVSP 685 Score = 85.9 bits (211), Expect = 2e-16 Identities = 137/657 (20%), Positives = 235/657 (35%), Gaps = 144/657 (21%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H A+ + + G R+AS D + V+ L +K H+D + F + + Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL--- 730 T D VK W+ T T H +V S L TG+SD L++WD+ Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEV--WGLVLLSEEKRLITGASDSELRVWDIAYL 223 Query: 731 ---------NQKECRNTMFGHTNSVN------HCRFSPDDKLLASCSA------------ 763 + K+ + + G +++ +P+D++L+ A Sbjct: 224 QEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVV 283 Query: 764 ----------------DGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEV 799 D L+L+ S E K K + + +ED EV Sbjct: 284 NLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEV 343 Query: 800 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859 V+ + KI FD+ IH+ H AV L Sbjct: 344 NVEMSLQDEIQRVTNIKTSAKIKSFDL--------IHSPHGEL-----------KAVFLL 384 Query: 860 SQYCVELWNTDS--------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911 VEL++ + R+ GH S V + FS D + L+++ D +I++W Sbjct: 385 QNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNR 443 Query: 912 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 971 LQ I RT +Y C P Sbjct: 444 S--------------------------------TLQCI--RTMTCEY-----ALCSFFVP 464 Query: 972 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1031 + + G + G +++ +L + + ++ H +W + + D++ ++ D ++ W+ Sbjct: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524 Query: 1032 WQLDKCIFLRGHQETVKDFRLLK------------NSRLLSWS-FDGTVKVWNIITGNKE 1078 ++L K + +VK R L+ N +LL+ S D TVK++ + T Sbjct: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584 Query: 1079 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1138 H+ V+ DISHD ++ SAD+ KIW D L H+ V F Sbjct: 585 LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPK 644 Query: 1139 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1195 S L T + +I+ W+ E + + EG H + L SP G ++S+ Sbjct: 645 SHLFFTAGKDHKIKQWDADKFEHIQ-----TLEG---HHQEIWCLAVSPSGDYVVSS 693 Score = 85.1 bits (209), Expect = 4e-16 Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 39/320 (12%) Query: 607 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFS 666 SR+ + H V FS D + S AD +++++ T + + + + LC F Sbjct: 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTC--EYALCSFFV 463 Query: 667 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 726 DR + + K+++++ +G L+ T D H + + + TG +D +K Sbjct: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFV--TGGADKSVK 521 Query: 727 LWDLNQKECRNTMFGHTNSVNHCR------------FSPDDKLLASCSADGTLKLWDATS 774 WD + N+ SV R +SP+ KLLA D T+K++ Sbjct: 522 FWDFELVKDENSTQKRL-SVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF---- 576 Query: 775 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LG 833 ++ +FFL+L + + V C S DGA I + ++ ++ GL G Sbjct: 577 -----YVDTLKFFLSLYGHK----LPVICMDISHDGALIATGSADR----NVKIWGLDFG 623 Query: 834 EIHTG---HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMF 890 + H H ++ Y F P++HL A + ++ W+ D + GH + + Sbjct: 624 DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683 Query: 891 SPDGSSFLTSSDDQTIRLWE 910 SP G ++SS D+++RLWE Sbjct: 684 SPSGDYVVSSSHDKSLRLWE 703 Score = 72.8 bits (177), Expect = 2e-12 Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%) Query: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682 +S + + +A D T+++F +T + L + H+ V+C S D IAT S D+ VK Sbjct: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616 Query: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742 IW G+ + H + V F SH L T D +K WD ++ E T+ GH Sbjct: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674 Query: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773 + SP + S S D +L+LW+ T Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705 Score = 64.7 bits (156), Expect = 5e-10 Identities = 117/612 (19%), Positives = 229/612 (37%), Gaps = 67/612 (10%) Query: 589 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 648 D ++ + IN+ + L + H DA+ A F + + + G D ++ + +T Sbjct: 128 DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182 Query: 649 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 708 + H EV ++++ + T + D ++++W+ + + E E+ + Sbjct: 183 CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI----EDPEEPDPKKIK 238 Query: 709 NSSHHLLLATGSSDCFLKLWD------LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 762 SS + + D + + L+ ++ + M + V + ++LA Sbjct: 239 GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHG 298 Query: 763 ADGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 814 D L+L+ S E K K + + +ED EV V+ Sbjct: 299 TDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTN 358 Query: 815 VAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDS--- 871 + KI FD+ IH+ H AV L VEL++ + Sbjct: 359 IKTSAKIKSFDL--------IHSPHGEL-----------KAVFLLQNNLVELYSLNPSLP 399 Query: 872 -----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEV 926 R+ GH S V + FS D + L+++ D +I++W + + + + Sbjct: 400 TPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL 458 Query: 927 DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCC---CLSPHLQYIAFGDENG 983 F + V+ +LQL + +G + +A LSP + G + Sbjct: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518 Query: 984 AIEI--LELVNNR-IFQSRFQHKKT--------VWHIQFTADEKTLISSSDDAEIQVWNW 1032 +++ ELV + Q R K+T V + ++ ++K L S D ++++ Sbjct: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578 Query: 1033 QLDKCIF-LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLS 1090 K L GH+ V + + L++ S D VK+W + G+ K H +V+ Sbjct: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638 Query: 1091 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1150 + F + D K W D + L GH+ + C A S + + + Sbjct: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698 Query: 1151 IRIWNVSNGELL 1162 +R+W + L+ Sbjct: 699 LRLWERTREPLI 710 Score = 60.5 bits (145), Expect = 1e-08 Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%) Query: 935 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 994 V V A +H+ L G I + +V+C C SP ++A G E+G+I I L++ Sbjct: 39 VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98 Query: 995 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 1053 + HK + +++ L S S D +I VW+ + ++ L+GH++ + L Sbjct: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158 Query: 1054 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1112 + LL S D VK W++ T + K V H+ V + + + + ++D ++W Sbjct: 159 REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218 Query: 1113 SFDLLLPLHE 1122 L + + Sbjct: 219 DIAYLQEIED 228 Score = 54.7 bits (130), Expect = 5e-07 Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 2/131 (1%) Query: 641 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 700 ++ GEK+L ++ + EV C S D +A D ++I++ ++GE T++ H Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108 Query: 701 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 760 + + LA+GS D + +WD+ + + GH +++ F + LL + Sbjct: 109 AITTLKYDQLGGR--LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166 Query: 761 CSADGTLKLWD 771 D +K WD Sbjct: 167 SGKDTMVKWWD 177 Score = 46.2 bits (108), Expect = 2e-04 Identities = 96/512 (18%), Positives = 187/512 (36%), Gaps = 71/512 (13%) Query: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 786 +WDL + E + G V SPD LA DG+++++ S + N Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN---- 104 Query: 787 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQY 845 + + + G R+ +K+ I ++D+ L + GH I Sbjct: 105 ---------GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-GHKDAITQ 154 Query: 846 CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 905 F + +L V + V+ W+ D++ GH + V G++ + +T + D Sbjct: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE 214 Query: 906 IRLWE-------------TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGR 952 +R+W+ K K S+ ++ ++ E D I L + Sbjct: 215 LRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRK 270 Query: 953 TGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTV 1006 G I +V + + +A + +E+ +++ + Q + KK Sbjct: 271 AGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAK 330 Query: 1007 WHIQFTADEKTLIS---SSDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLL 1059 H +E ++ S D +V N + I + +K LL+N+ + Sbjct: 331 LHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVE 390 Query: 1060 SWSFDGT------VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113 +S + + V+ I G D V + S D S +AD + KIW+ Sbjct: 391 LYSLNPSLPTPQPVRTSRITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWN 442 Query: 1114 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173 L + + CS F + G G+++++++++G LL E Sbjct: 443 RSTLQCIRTMTCEYAL--CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETI 492 Query: 1174 ATHGGWVTDLCFSPDGKMLISAGG--YIKWWN 1203 H G + + SPD + ++ G +K+W+ Sbjct: 493 DAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524 Score = 40.4 bits (93), Expect = 0.011 Identities = 19/88 (21%), Positives = 39/88 (44%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H D+V + F + G D ++ + A+ E + ++ H E+ C A S ++ Sbjct: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 701 + S DK +++W L+ + E+ Sbjct: 692 SSSHDKSLRLWERTREPLILEEEREMER 719 Score = 39.7 bits (91), Expect = 0.018 Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%) Query: 1029 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1084 V+ W L +K + L+G ++ V + L+ + DG+++++++++G F H Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106 Query: 1085 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1144 + + + + +S S D +W L+ L+GH + + F + LL T Sbjct: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166 Query: 1145 GDDNGEIRIWNV 1156 + ++ W++ Sbjct: 167 SGKDTMVKWWDL 178 Score = 31.2 bits (69), Expect = 6.5 Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%) Query: 1125 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1184 GH + + LA+G + +I +W+V N L+ H +T Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156 Query: 1185 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234 F + +L+++G +KWW++ T +T + T + + + + K +T Sbjct: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208 >gi|5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo sapiens] Length = 317 Score = 95.5 bits (236), Expect = 3e-19 Identities = 82/317 (25%), Positives = 135/317 (42%), Gaps = 51/317 (16%) Query: 597 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654 W ++ TN + + +R H+ V S DGQ S D TL+++ TG Sbjct: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102 Query: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 713 H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S + Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 Query: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773 ++ + D +K+W+L + + GHT +N SPD L AS DG LWD Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL- 221 Query: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 833 NE K + + L+ D I+ +S + + A I ++D+ ++ Sbjct: 222 --NEGKHL----YTLDGGD-------IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD 268 Query: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 893 E+ E+ +T S+++ C L+W S D Sbjct: 269 ELKQ---------------------------EVISTSSKAEPPQCTS-LAW------SAD 294 Query: 894 GSSFLTSSDDQTIRLWE 910 G + D +R+W+ Sbjct: 295 GQTLFAGYTDNLVRVWQ 311 Score = 79.7 bits (195), Expect = 2e-14 Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%) Query: 1018 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1070 ++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 Query: 1071 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1129 ++ TG + FV H VLS S D + S S DKT K+W + + + H+ Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 Query: 1130 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1186 V C FS +S+ +++ G D +++WN++N +L + H G++ + S Sbjct: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201 Query: 1187 PDGKMLISAG--GYIKWWNVVTGESSQT 1212 PDG + S G G W++ G+ T Sbjct: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229 Score = 68.2 bits (165), Expect = 5e-11 Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%) Query: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 1023 VS +S Q+ G +G + + +L + H K V + F++D + ++S S Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 Query: 1024 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1077 D I++WN L C + H E V R NS ++S +D VKVWN+ Sbjct: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 Query: 1078 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1137 + + + H G + + +S D + +S D A +W + L+ L G + FS Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243 Query: 1138 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1193 + L ATG I+IW++ G+++ L + + T L +S DG+ L Sbjct: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 Query: 1194 S--AGGYIKWWNVVTG 1207 + ++ W V G Sbjct: 300 AGYTDNLVRVWQVTIG 315 Score = 53.5 bits (127), Expect = 1e-06 Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 21/204 (10%) Query: 715 LLATGSSDCFLKLWDLNQKEC-----RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKL 769 ++ + S D + +W L + E + + GH++ V+ S D + S S DGTL+L Sbjct: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 Query: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 828 WD T+ ++F + +D V ++S+D +I+ +++K I L++ Sbjct: 90 WDLTTGT-----TTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 Query: 829 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVH 886 H + FSP + ++ + V++WN + + GH +++ Sbjct: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 Query: 887 GVMFSPDGSSFLTSSDDQTIRLWE 910 V SPDGS + D LW+ Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWD 220 Score = 45.4 bits (106), Expect = 3e-04 Identities = 48/248 (19%), Positives = 96/248 (38%), Gaps = 24/248 (9%) Query: 879 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVM 936 RGH +V V+ S DG L+ S D T+RLW+ T + K + V F + Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 Query: 937 VLAVDHIRRLQLINGRTGQIDYLTEAQ-----VSCCCLSPHLQ--YIAFGDENGAIEILE 989 +++ + ++L N G Y + + VSC SP+ I + +++ Sbjct: 120 IVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 Query: 990 LVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKD 1049 L N ++ + H + + + D S D + +W+ K ++ + + Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 Query: 1050 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADK-- 1107 N L + ++K+W++ +G ++ ++ + SS + Sbjct: 239 LCFSPNRYWLCAATGPSIKIWDL------------EGKIIVDELKQEVISTSSKAEPPQC 286 Query: 1108 TAKIWSFD 1115 T+ WS D Sbjct: 287 TSLAWSAD 294 Score = 40.0 bits (92), Expect = 0.014 Identities = 23/79 (29%), Positives = 33/79 (41%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + S A+ + LW+ + + GH V V FS D Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 Query: 898 LTSSDDQTIRLWETKKVCK 916 ++ S D+TI+LW T VCK Sbjct: 121 VSGSRDKTIKLWNTLGVCK 139 Score = 37.4 bits (85), Expect = 0.090 Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%) Query: 1123 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1179 L+GHNG V A + D L A+ D I +W ++ E + + + H + Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65 Query: 1180 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234 V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+ Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 94.0 bits (232), Expect = 8e-19 Identities = 81/335 (24%), Positives = 143/335 (42%), Gaps = 39/335 (11%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H++AV FS G+ +AS D T++ + T K H VL ++S D R +A Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172 Query: 674 TCSVDKKVKIWNSMTGELV-HTYDEHSEQVNCCHFT---NSSHHLLLATGSSDCFLKLWD 729 + + ++ +W+ TG+ V T HS+ + + + +A+ S D +++WD Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA----------------- 772 C + GHT SV R+ D LL S S D T+K+W A Sbjct: 233 TTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291 Query: 773 -----------TSANE--RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 819 T A E S+N + +L++ +E + + G +V+ + Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE--RALSRYNLVRGQGPERLVSGSD 349 Query: 820 --KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVAD 877 +FL+ TGH + I FSP + + A ++LW+ + +A Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409 Query: 878 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 912 RGH++ V+ + +S D ++ S D T+++W+ K Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444 Score = 92.8 bits (229), Expect = 2e-18 Identities = 109/429 (25%), Positives = 172/429 (40%), Gaps = 60/429 (13%) Query: 735 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 794 C +++ GH+ +V FSP K LAS S D T++ WD ++ + + + Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW------- 158 Query: 795 EDMEVIVKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN- 852 V SWS DG ++ KN +I L+D T +G GH I + P + Sbjct: 159 ------VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212 Query: 853 --HLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 908 VA S V +W+T + GH V + + DG + ++S D+TI++ Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271 Query: 909 WETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCC 968 W + V+ + N M L+ D+ R TG + EA V+ Sbjct: 272 WRA-----HDGVLCRTLQGHGHWVN-TMALSTDYALR-------TGAFEP-AEASVNPQD 317 Query: 969 LSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQ 1028 L LQ + + A+ LV + + L+S SDD + Sbjct: 318 LQGSLQEL----KERALSRYNLVRGQ-------------------GPERLVSGSDDFTLF 354 Query: 1029 VWNWQLDKCIFLR--GHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQ 1085 +W+ DK R GHQ + +SR++ S SFD ++K+W+ TG H Sbjct: 355 LWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHV 414 Query: 1086 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1145 V S D+ S S+D T K+W +L GH V +S D +A+G Sbjct: 415 AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 474 Query: 1146 DDNGEIRIW 1154 + +RIW Sbjct: 475 GKDKCLRIW 483 Score = 77.4 bits (189), Expect = 8e-14 Identities = 89/404 (22%), Positives = 143/404 (35%), Gaps = 85/404 (21%) Query: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897 GH + FSP V W+ + + C+GH WV + +SPDG Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171 Query: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957 + CKN ++L D Q+ G Sbjct: 172 ASG--------------CKNGQILLW-----------------DPSTGKQVGRTLAGHSK 200 Query: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017 ++T +P +Y+A ++G++ I + R + H ++V +++ D Sbjct: 201 WITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259 Query: 1018 LISSSDDAEIQVWNWQLDK-CIFLRGHQETVKDFRLLKN--------------------- 1055 L S+S D I+VW C L+GH V L + Sbjct: 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ 319 Query: 1056 ----------------------SRLLSWSFDGTVKVWNIITGNKEKDFVC-HQGTVLSCD 1092 RL+S S D T+ +W+ K + HQ + Sbjct: 320 GSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVL 379 Query: 1093 ISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIR 1152 S D+ +S S DK+ K+W L LRGH V A+S DS LL +G + ++ Sbjct: 380 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439 Query: 1153 IWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196 +W+V + L + P H V + +SPDG+ + S G Sbjct: 440 VWDV-KAQKLAMDLP-------GHADEVYAVDWSPDGQRVASGG 475 Score = 74.3 bits (181), Expect = 7e-13 Identities = 46/153 (30%), Positives = 78/153 (50%), Gaps = 3/153 (1%) Query: 619 YHACFSEDGQRIASCGADKTLQVFK-AETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677 Y+ + +R+ S D TL ++ AE + L + H+ + FS D R +A+ S Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392 Query: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737 DK +K+W+ TG+ + + H V ++ S LL +GSSD LK+WD+ ++ Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR--LLVSGSSDSTLKVWDVKAQKLAM 450 Query: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770 + GH + V +SPD + +AS D L++W Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483 Score = 69.3 bits (168), Expect = 2e-11 Identities = 105/476 (22%), Positives = 194/476 (40%), Gaps = 75/476 (15%) Query: 621 ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKK 680 A F D + ++S G KTL+ ET EK+L+I + R + C+ Sbjct: 61 AFFVHDAEIVSSLG--KTLESQAVET-EKVLDIIYQPQAIFRV------RAVTRCT---- 107 Query: 681 VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 740 +S+ G HSE V F+ + +L A+GS D ++ WDL+ + T Sbjct: 108 ----SSLEG--------HSEAVISVAFSPTGKYL--ASGSGDTTVRFWDLSTETPHFTCK 153 Query: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE--RKSINVKQFFLNLEDPQEDME 798 GH + V +SPD + LAS +G + LWD ++ + R ++ L E + Sbjct: 154 GHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLS--WEPLH 211 Query: 799 VIVKC---CSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLA 855 +C S S DG+ + ++D T+G I TGH ++ C + L Sbjct: 212 ANPECRYVASSSKDGS---------VRIWDT-TAGRCERILTGHTQSVT-CLRWGGDGLL 260 Query: 856 VVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD----------GSSFLTSSDDQ- 904 A +++W +GH WV+ + S D + + D Q Sbjct: 261 YSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG 320 Query: 905 TIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQV 964 +++ + + + + + V + +V ++ + + + TG +A + Sbjct: 321 SLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGH-----QALI 375 Query: 965 SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDD 1024 + SP + +A + +I++ + + S H V+ I ++AD + L+S S D Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 435 Query: 1025 AEIQVWNWQLDK-CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1079 + ++VW+ + K + L GH + V + WS DG + +G K+K Sbjct: 436 STLKVWDVKAQKLAMDLPGHADEV---------YAVDWSPDGQ----RVASGGKDK 478 Score = 65.1 bits (157), Expect = 4e-10 Identities = 61/281 (21%), Positives = 106/281 (37%), Gaps = 59/281 (20%) Query: 630 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTG 689 +AS D +++++ G + H V C + D + + S D+ +K+W + G Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG 277 Query: 690 ELVHTYDEHSEQVNCCHFTN---------------------------------SSHHLL- 715 L T H VN + S ++L+ Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337 Query: 716 ------LATGSSDCFLKLWD-LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 768 L +GS D L LW K+ M GH +N FSPD +++AS S D ++K Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397 Query: 769 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLFDI 826 LWD + S+ V +WSAD +R++V ++ + + ++D+ Sbjct: 398 LWDGRTGKYLASL-------------RGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDV 443 Query: 827 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 867 L ++ GH + D+SP C+ +W Sbjct: 444 KAQKLAMDL-PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483 Score = 56.6 bits (135), Expect = 1e-07 Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 7/130 (5%) Query: 599 NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHED 658 +KK +T ++ H + FS D + +AS DK+++++ TG+ L ++ H Sbjct: 361 DKKPLTRMTG-----HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415 Query: 659 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 718 V A+S D R + + S D +K+W+ +L H+++V ++ +A+ Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQR--VAS 473 Query: 719 GSSDCFLKLW 728 G D L++W Sbjct: 474 GGKDKCLRIW 483 Score = 50.4 bits (119), Expect = 1e-05 Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 14/131 (10%) Query: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLA 1143 H V+S S +S S D T + W P +GH V ++S D LA Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172 Query: 1144 TGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF-----SPDGKMLISAG-- 1196 +G NG+I +W+ S G+ + A H W+T L + +P+ + + S+ Sbjct: 173 SGCKNGQILLWDPSTGKQV-------GRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225 Query: 1197 GYIKWWNVVTG 1207 G ++ W+ G Sbjct: 226 GSVRIWDTTAG 236 Score = 46.6 bits (109), Expect = 1e-04 Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 16/132 (12%) Query: 1123 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTD 1182 L GH+ V AFS LA+G + +R W++S C H WV Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC--------KGHRHWVLS 161 Query: 1183 LCFSPDGKMLISA--GGYIKWWNVVTGE------SSQTFYTNGTNLKKIHVSPDFKTYVT 1234 + +SPDG+ L S G I W+ TG+ + + + G + + +H +P+ + + Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221 Query: 1235 VDNLGILYILQT 1246 G + I T Sbjct: 222 SSKDGSVRIWDT 233 Score = 39.3 bits (90), Expect = 0.024 Identities = 49/200 (24%), Positives = 79/200 (39%), Gaps = 20/200 (10%) Query: 1040 LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVC--HQGTVLSCDISHD 1096 L GH E V + L S S D TV+ W++ T + F C H+ VLS S D Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST--ETPHFTCKGHRHWVLSISWSPD 167 Query: 1097 ATKFSSTSADKTAKIWSFDLLLPL-HELRGHNGCVRCSAF-----SVDSTLLATGDDNGE 1150 K +S + +W + L GH+ + ++ + + +A+ +G Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227 Query: 1151 IRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGES 1209 +RIW+ + G E H VT L + DG + S IK W G Sbjct: 228 VRIWDTTAGR--------CERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVL 279 Query: 1210 SQTFYTNGTNLKKIHVSPDF 1229 +T +G + + +S D+ Sbjct: 280 CRTLQGHGHWVNTMALSTDY 299 Score = 35.0 bits (79), Expect = 0.45 Identities = 15/30 (50%), Positives = 21/30 (70%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFK 643 H D VY +S DGQR+AS G DK L++++ Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWR 484 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 92.8 bits (229), Expect = 2e-18 Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%) Query: 654 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 709 +AH+D + A+ T+ + + T S+D VK+W L + Q+ + Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71 Query: 710 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 767 SH L +A SS D ++LWDL N K+ ++ G ++ FSPD + LA+ + G + Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130 Query: 768 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 825 ++ S + S++ + +F L++ ++S DG + A + I +FD Sbjct: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176 Query: 826 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 885 I T LL + GH I+ FSP + L V A +++++ + GH SWV Sbjct: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235 Query: 886 HGVMFSPDGSSFLTSSDDQTIRLWE 910 V F PD + F++SS D+++++W+ Sbjct: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260 Score = 85.9 bits (211), Expect = 2e-16 Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Query: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682 FS D Q +A+ + +F E+G+K + +L A+S D +++A+ ++D + Sbjct: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173 Query: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742 I++ TG+L+HT + H+ + F+ S LL T S D ++K++D+ T+ GH Sbjct: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231 Query: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWD 771 + V + F PDD S S+D ++K+WD Sbjct: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260 Score = 76.3 bits (186), Expect = 2e-13 Identities = 64/255 (25%), Positives = 106/255 (41%), Gaps = 52/255 (20%) Query: 995 IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1050 +F+ H +W + + ++K T+++ S D ++VW W +D Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---------------RDE 52 Query: 1051 RLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAK 1110 RL L WS +G HQ V+S DISH +S+S D + Sbjct: 53 RL-----DLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHIR 89 Query: 1111 IWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSE 1170 +W + + + AFS DS LATG G++ I+ V +G+ E Sbjct: 90 LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------KE 141 Query: 1171 EGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1228 T G ++ + +SPDGK L S G I +++ TG+ T + ++ + SPD Sbjct: 142 YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD 201 Query: 1229 FKTYVTVDNLGILYI 1243 + VT + G + I Sbjct: 202 SQLLVTASDDGYIKI 216 Score = 69.3 bits (168), Expect = 2e-11 Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%) Query: 942 HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 999 HIR L NG+ QI + V L SP QY+A G G + I + + + S Sbjct: 87 HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144 Query: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1058 K + I ++ D K L S + D I +++ K + L GH ++ +S+L Sbjct: 145 DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204 Query: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117 L + S DG +K++++ N H VL+ D T F S+S+DK+ K+W Sbjct: 205 LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264 Query: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155 +H H V ++ + + + + D+ EI I++ Sbjct: 265 TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 51.6 bits (122), Expect = 5e-06 Identities = 26/89 (29%), Positives = 41/89 (46%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H + FS D Q + + D ++++ + + H VL AF DD Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFV 248 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQV 702 + S DK VK+W+ T VHT+ +H +QV Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 90.1 bits (222), Expect = 1e-17 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V R HT V F DGQ + DKT++V+ + L + H + V C FS D Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729 R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 177 Query: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 + H+ +VN F P L + S+D TLK+ D Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219 Score = 89.7 bits (221), Expect = 2e-17 Identities = 63/229 (27%), Positives = 100/229 (43%), Gaps = 12/229 (5%) Query: 1024 DAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDF 1081 D+ + VW+ + + GH++ V + LL S S D TV++W + F Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61 Query: 1082 VCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1141 H TV S D F + S DKT K+W+ L L H VRC+ FS D L Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121 Query: 1142 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYI 1199 + + D+ +++W+ S+ E +H HGG+VT + F P G + +AG + Sbjct: 122 IVSASDDKTVKLWDKSSRECVH--------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173 Query: 1200 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248 K W+V T Q + + + + P +T + L IL +E Sbjct: 174 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222 Score = 88.2 bits (217), Expect = 4e-17 Identities = 69/278 (24%), Positives = 118/278 (42%), Gaps = 19/278 (6%) Query: 636 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW-NSMTGELVHT 694 D L V+ + + H+D V C FS +A+ S DK V+IW ++ GE Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-V 60 Query: 695 YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPD 754 + H+ V HF + + T S D +K+W ++++ ++ H N V +FSPD Sbjct: 61 FRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118 Query: 755 DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 814 +L+ S S D T+KLWD +S S F+ D + G I Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD-------------FHPSGTCIA 165 Query: 815 VAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRS 873 A N + ++D+ T LL + + H + + F P + + A S +++ + Sbjct: 166 AAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 224 Query: 874 KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911 + GH V FS G F + D+ + +W++ Sbjct: 225 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262 Score = 85.5 bits (210), Expect = 3e-16 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H DAV FS G +AS DKT++++ + +AH V F +D + Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 T S DK VK+W + + + + +H V C F+ L+ + S D +KLWD + + Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 139 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 EC ++ H V + F P +A+ D T+K+WD Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177 Score = 83.2 bits (204), Expect = 1e-15 Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 15/232 (6%) Query: 677 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR 736 +D + +W+ + + H + V C +F+ S H LLA+GS D +++W N K Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGES 58 Query: 737 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 796 HT +V F D + + S D T+K+W + + ++F +L Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW---------ATHRQKFLFSLSQHIN- 108 Query: 797 MEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 856 V+C +S DG I+ A+ +K +S + H + Y DF P Sbjct: 109 ---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 165 Query: 857 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 908 A V++W+ + + + H + V+G+ F P G+ +T+S D T+++ Sbjct: 166 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217 Score = 74.7 bits (182), Expect = 5e-13 Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%) Query: 837 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 896 TGH + +FSP HL V +W + + + R H + V V F DG S Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79 Query: 897 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 956 F+T+SDD+T+++W T + + L Q ++ Sbjct: 80 FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 108 Query: 957 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1016 V C SP + I ++ +++ + + S +H V ++ F Sbjct: 109 ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162 Query: 1017 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074 + ++ D ++VW+ + + + + H V + L++ S D T+K+ +++ Sbjct: 163 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222 Query: 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1117 G HQG + S F+S +D+ +W +FD++ Sbjct: 223 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 267 Score = 73.2 bits (178), Expect = 1e-12 Identities = 69/313 (22%), Positives = 122/313 (38%), Gaps = 46/313 (14%) Query: 863 CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVML 922 C+ +W+ +S+ GH V V FSP G + S D+T+R+W + Sbjct: 4 CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN---------V 54 Query: 923 KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDEN 982 K E VF+ + V +V + ++ Q ++ D+ Sbjct: 55 KGE-STVFRAHTATVRSVH----------------FCSDGQ----------SFVTASDDK 87 Query: 983 GAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL-- 1040 +++ + S QH V +F+ D + ++S+SDD +++W+ +C+ Sbjct: 88 -TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 146 Query: 1041 -RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK 1099 G T DF + + + D TVKVW++ T + + H V Sbjct: 147 EHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205 Query: 1100 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN---- 1155 + S+D T KI L+ L GH G AFS A+G + ++ +W Sbjct: 206 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 265 Query: 1156 -VSNGELLHLCAP 1167 V +GE+ + P Sbjct: 266 IVDHGEVTKVPRP 278 Score = 71.2 bits (173), Expect = 6e-12 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%) Query: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1022 V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84 Query: 1023 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1080 DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ + Sbjct: 85 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144 Query: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140 + H G V D T ++ D T K+W L + H+ V +F Sbjct: 145 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204 Query: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196 L T + ++I ++ G LL+ H G T + FS G+ S G Sbjct: 205 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 252 Score = 70.9 bits (172), Expect = 7e-12 Identities = 51/240 (21%), Positives = 101/240 (42%), Gaps = 5/240 (2%) Query: 801 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 860 V C ++S G + +++K + + H +T++ F V A Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85 Query: 861 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 919 V++W T + + H++WV FSPDG +++SDD+T++LW+ + + C +S Sbjct: 86 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 145 Query: 920 VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 975 V V F + + A +++ + RT ++ L A V+ P Y Sbjct: 146 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205 Query: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1035 + + ++IL+L+ R+ + H+ + F+ + S D ++ VW D Sbjct: 206 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 265 Score = 38.9 bits (89), Expect = 0.031 Identities = 19/73 (26%), Positives = 32/73 (43%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H+ AV F G + + +D TL++ G L + H+ AFS + A Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 249 Query: 674 TCSVDKKVKIWNS 686 + D++V +W S Sbjct: 250 SGGSDEQVMVWKS 262 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 89.7 bits (221), Expect = 2e-17 Identities = 51/164 (31%), Positives = 83/164 (50%), Gaps = 2/164 (1%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H V+ FS G S G D+ +++ + + L H +V C F + ++A Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 T S D+ V++W+ + G V + H ++ F+ + LATG++D + LWD+ Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHG 701 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777 + GHT++V RFS D ++LAS S D T++LWDA A E Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745 Score = 81.3 bits (199), Expect = 5e-15 Identities = 46/158 (29%), Positives = 78/158 (49%), Gaps = 2/158 (1%) Query: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673 H+ VY A FS D + S D T++++ +T L+ K H V FS + Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601 Query: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733 + D+ ++W + + + + H VNC F +S++ +ATGS+D ++LWD+ Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY--VATGSADRTVRLWDVLNG 659 Query: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771 C GH ++ FSP+ + LA+ + DG + LWD Sbjct: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697 Score = 79.0 bits (193), Expect = 3e-14 Identities = 74/323 (22%), Positives = 132/323 (40%), Gaps = 65/323 (20%) Query: 754 DDKLLASCSADGTLKLWDATSANERKSINVKQFF-LNLEDPQEDMEVIVKCCSWSADGAR 812 D L+A AD T+++W T +K +VKQ L+L D + D +V+ + Sbjct: 481 DSSLIAGGFADSTVRVWSVTP---KKLRSVKQASDLSLIDKESD-DVLER---------- 526 Query: 813 IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSR 872 + D T+ L +I GH + FSP + + + V LW+ + Sbjct: 527 ----------IMDEKTASEL-KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575 Query: 873 SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQE 932 + + +GH V FSP G F++ D+ RLW T Sbjct: 576 TCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT--------------------- 614 Query: 933 NEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVN 992 DH + L++ G A V+C P+ Y+A G + + + +++N Sbjct: 615 --------DHYQPLRIFAGHL--------ADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658 Query: 993 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFR 1051 + HK + + F+ + + L + + D + +W+ + L+GH +TV R Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718 Query: 1052 LLKNSRLL-SWSFDGTVKVWNII 1073 ++ +L S S D TV++W+ I Sbjct: 719 FSRDGEILASGSMDNTVRLWDAI 741 Score = 76.6 bits (187), Expect = 1e-13 Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 14/268 (5%) Query: 893 DGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE-VMVLAVDH--IRRLQLI 949 D S D T+R+W K +V ++ ++ +E++ V+ +D L+++ Sbjct: 481 DSSLIAGGFADSTVRVWSVTPK-KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539 Query: 950 NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 1009 G +G V SP Y+ E+G + + L H VW Sbjct: 540 YGHSGP--------VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591 Query: 1010 QFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSW-SFDGTV 1067 QF+ +S D ++W + + GH V R NS ++ S D TV Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651 Query: 1068 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHN 1127 ++W+++ GN + F H+G + S S + ++ + D +W L + EL+GH Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711 Query: 1128 GCVRCSAFSVDSTLLATGDDNGEIRIWN 1155 V FS D +LA+G + +R+W+ Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 72.4 bits (176), Expect = 3e-12 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 10/152 (6%) Query: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117 LLS S DGTV++W++ T + H V S F S D+ A++W+ D Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617 Query: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1177 PL GH V C+ F +S +ATG + +R+W+V NG + + H Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--------FTGHK 669 Query: 1178 GWVTDLCFSPDGKMLISAG--GYIKWWNVVTG 1207 G + L FSP+G+ L + G + W++ G Sbjct: 670 GPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701 Score = 70.9 bits (172), Expect = 7e-12 Identities = 77/291 (26%), Positives = 115/291 (39%), Gaps = 28/291 (9%) Query: 624 SEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 683 ++D IA AD T++V+ T +KL +K D L I S D +I Sbjct: 479 TDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASDLSL----------IDKESDDVLERI 527 Query: 684 WNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT 743 + T + HS V F+ ++LL + S D ++LW L C GH Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLL--SSSEDGTVRLWSLQTFTCLVGYKGHN 585 Query: 744 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 803 V +FSP S D +LW AT + I F +L D V C Sbjct: 586 YPVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRI----FAGHLAD--------VNC 632 Query: 804 CSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY 862 + + + + ++ + L+D+ +G I TGH I FSP + Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDV-LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691 Query: 863 CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 913 V LW+ V + +GH V + FS DG + S D T+RLW+ K Sbjct: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742 Score = 36.6 bits (83), Expect = 0.15 Identities = 35/110 (31%), Positives = 49/110 (44%), Gaps = 20/110 (18%) Query: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670 ++ HTD V FS DG+ +AS D T++++ A IKA ED TDD Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA--------IKAFED------LETDDF 752 Query: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720 AT ++ + G TY S V HFT +L+LA G+ Sbjct: 753 TTATGHINLPENSQELLLG----TYMTKSTPVVHLHFTR--RNLVLAAGA 796 >gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo sapiens] Length = 421 Score = 89.7 bits (221), Expect = 2e-17 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%) Query: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 G +W V F+PDGS F S +T++L + +N F + + Sbjct: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79 Query: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 RL N GQ + E + C + +AFG + + + + Sbjct: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123 Query: 1000 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1057 + WH +F D+ L + ++ I++W+ K + L H E V+D + Sbjct: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183 Query: 1058 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1114 L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+ Sbjct: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243 Query: 1115 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1170 D + +L GH+ V FS D LLAT + + IW+ NG++L HL P + Sbjct: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303 Query: 1171 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1204 A + WV + FS DG + S +++W + Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340 Score = 84.0 bits (206), Expect = 8e-16 Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%) Query: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742 +W+ G V + F LLLATG ++ +K+WD+ + + H Sbjct: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169 Query: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800 T V F+PD L L S S D TL++WD L+D M+V+ Sbjct: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211 Query: 801 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 854 V C++S D + + V A +FL+++ ++ ++ GHH + CDFSP L Sbjct: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270 Query: 855 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 900 A V +W+ + + + GHL WV V FS DG + Sbjct: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329 Query: 901 SDDQTIRLW 909 +DD+ +R W Sbjct: 330 ADDKMVRFW 338 Score = 72.8 bits (177), Expect = 2e-12 Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%) Query: 750 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809 RF D LLA+ +G +K+WD + + LNL D E +V+ +++ D Sbjct: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181 Query: 810 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 867 G+ I+V+A + ++D+ G + ++ GH + + C FSP + + + V LW Sbjct: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241 Query: 868 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910 N D + + GH V FSPDG+ T+S D + +W+ Sbjct: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 Score = 65.5 bits (158), Expect = 3e-10 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%) Query: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D Sbjct: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268 Query: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716 +AT S D +V IW+ G+++ + + V F++ H + Sbjct: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326 Query: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770 A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W Sbjct: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 Score = 64.7 bits (156), Expect = 5e-10 Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%) Query: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671 HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 Query: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731 + + K V +WN ++ + H V C F S LLAT S D + +WD + Sbjct: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286 Query: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777 + FGH V FS D +AS + D ++ W +E Sbjct: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342 Query: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 811 + V L CC++S DG+ Sbjct: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364 Score = 44.7 bits (104), Expect = 6e-04 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%) Query: 820 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 877 +I ++D++T LL + H ++ F+P L +V+ S+ + +W+ D + + Sbjct: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209 Query: 878 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 913 RGH +WV+ FSPD S + + + LW K Sbjct: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.134 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 47,392,737 Number of Sequences: 37866 Number of extensions: 2114543 Number of successful extensions: 10492 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 212 Number of HSP's successfully gapped in prelim test: 119 Number of HSP's that attempted gapping in prelim test: 5081 Number of HSP's gapped (non-prelim): 2779 length of query: 1248 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1134 effective length of database: 13,930,794 effective search space: 15797520396 effective search space used: 15797520396 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.