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Search of human proteins with 31742501
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31742501 sorting nexin family member 27 [Homo sapiens]
(528 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31742501 sorting nexin family member 27 [Homo sapiens] 1088 0.0
gi|7661890 sorting nexin 17 [Homo sapiens] 125 1e-28
gi|222537716 sorting nexin 31 [Homo sapiens] 119 9e-27
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 71 3e-12
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 71 3e-12
gi|8922944 lin-7 homolog C [Homo sapiens] 69 1e-11
gi|11545920 lin-7 homolog B [Homo sapiens] 69 1e-11
gi|4759306 lin-7 homolog A [Homo sapiens] 67 5e-11
gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2 ... 66 9e-11
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 66 9e-11
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 62 2e-09
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 61 2e-09
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 60 5e-09
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 58 2e-08
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 57 4e-08
gi|21361142 PDZ domain containing 1 [Homo sapiens] 57 5e-08
gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo... 57 5e-08
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 56 7e-08
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 56 7e-08
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 56 7e-08
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 55 2e-07
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 55 2e-07
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 55 2e-07
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 54 3e-07
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 54 3e-07
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 54 5e-07
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 54 5e-07
gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo ... 52 1e-06
gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo... 52 1e-06
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 52 2e-06
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 1088 bits (2814), Expect = 0.0
Identities = 528/528 (100%), Positives = 528/528 (100%)
Query: 1 MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQ 60
MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQ
Sbjct: 1 MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQ 60
Query: 61 VSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDL 120
VSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDL
Sbjct: 61 VSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDL 120
Query: 121 IRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKF 180
IRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKF
Sbjct: 121 IRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKF 180
Query: 181 VVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLE 240
VVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLE
Sbjct: 181 VVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLE 240
Query: 241 EYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQV 300
EYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQV
Sbjct: 241 EYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQV 300
Query: 301 YQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKW 360
YQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKW
Sbjct: 301 YQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKW 360
Query: 361 LFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRT 420
LFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRT
Sbjct: 361 LFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRT 420
Query: 421 CEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTD 480
CEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTD
Sbjct: 421 CEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTD 480
Query: 481 EEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKEEY 528
EEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKEEY
Sbjct: 481 EEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKEEY 528
>gi|7661890 sorting nexin 17 [Homo sapiens]
Length = 470
Score = 125 bits (313), Expect = 1e-28
Identities = 100/383 (26%), Positives = 169/383 (44%), Gaps = 40/383 (10%)
Query: 174 EQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLD 233
+ G +V YN+++ G C RY + LH+ L++E+ P P K FSL+ +++
Sbjct: 14 DSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVE 73
Query: 234 ARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGV--SDVELRVALPDGTTVTVRV 291
RR LE+Y++ V ++G S+ FL + + V +V L V L +G V V V
Sbjct: 74 QRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNV 133
Query: 292 KKNSTTDQVYQAIAAKVGMDSTTVNYFALF-----EVISHSFVRKLAPNEFPH----KLY 342
+ T+ V +A+AAK+ + + YF+LF E + SFVRKL E P+ L
Sbjct: 134 LTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLR 193
Query: 343 IQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYI-KAEEKSYQ 401
Q Y + +RK + + + + +N + + + Q V D+++G+I +E+ Q
Sbjct: 194 SQEYK-------IVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQ 246
Query: 402 LQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKG-HVITAISITHFKLHACTEEG 460
L+ L E+ +L + +T Y + F C D K V+ + + L
Sbjct: 247 LKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQ 306
Query: 461 QLENQVIAFEWDEMQRW-----------DTDEEG-------MAFCFEYARGEKKPRWVKI 502
QL +F M+ W T G + FEY + + +WV I
Sbjct: 307 QLREG--SFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTI 364
Query: 503 FTPYFNYMHECFERVFCELKWRK 525
+P M C + + EL +K
Sbjct: 365 TSPQAIMMSICLQSMVDELMVKK 387
>gi|222537716 sorting nexin 31 [Homo sapiens]
Length = 440
Score = 119 bits (297), Expect = 9e-27
Identities = 91/381 (23%), Positives = 172/381 (45%), Gaps = 32/381 (8%)
Query: 163 VPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGK 222
+P+S R + G ++V+Y+V++ G C RY + ++ L+R F N P P K
Sbjct: 7 IPVSQQRSDAL---GGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFGN-CLPPFPPK 62
Query: 223 WPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVE--LRVA 280
+ +++ D RR LE+YL+ V + SD+ EFL + N ++ + L +
Sbjct: 63 YYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIF 122
Query: 281 LPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVI-----SHSFVRKLAPN 335
LP+ ++ + + + T ++V + ++ K+G+ + YF LF + S V+KLA
Sbjct: 123 LPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADF 182
Query: 336 EFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKA 395
E P Y+ +S V + +RKW + +L D +AV + QA+ D++KG+ K
Sbjct: 183 ELP---YVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKP 239
Query: 396 EEKSYQ-LQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLH 454
+ Q L+ ++ +L + R Y + C CD G +S+ + ++
Sbjct: 240 TQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSG-AVLSVGNNEIS 298
Query: 455 ACTEEGQLENQVIAFEWDEMQRW---------DTD------EEGMAFCFEYARGEKKPRW 499
C + Q I F+ ++ W DTD + + F+Y+ + +W
Sbjct: 299 CCITLPDSQTQDIVFQMSRVKCWQVTFLGTLLDTDGPQRTLNQNLELRFQYSE-DSCWQW 357
Query: 500 VKIFTPYFNYMHECFERVFCE 520
I+T + C +++ E
Sbjct: 358 FVIYTKQAFLLSSCLKKMISE 378
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 70.9 bits (172), Expect = 3e-12
Identities = 39/93 (41%), Positives = 53/93 (56%), Gaps = 13/93 (13%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+ R+V+ E GYGF++ G+ GQ + V PG A+ A +R GDR
Sbjct: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQF-------------IRRVEPGSPAEAAALRAGDR 55
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
++EVN VNVEG TH QVV I+A E + L V+
Sbjct: 56 LVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/93 (38%), Positives = 49/93 (52%), Gaps = 13/93 (13%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+ + K GYGFN+ S GQ ++ +V PG A R+G+R DR
Sbjct: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-------------YIRSVDPGSPAARSGLRAQDR 195
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
++EVN NVEG H +VV I+A E E L V+
Sbjct: 196 LIEVNGQNVEGLRHAEVVASIKAREDEARLLVV 228
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 70.9 bits (172), Expect = 3e-12
Identities = 39/93 (41%), Positives = 53/93 (56%), Gaps = 13/93 (13%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+ R+V+ E GYGF++ G+ GQ + V PG A+ A +R GDR
Sbjct: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQF-------------IRRVEPGSPAEAAALRAGDR 55
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
++EVN VNVEG TH QVV I+A E + L V+
Sbjct: 56 LVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/93 (38%), Positives = 49/93 (52%), Gaps = 13/93 (13%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+ + K GYGFN+ S GQ ++ +V PG A R+G+R DR
Sbjct: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-------------YIRSVDPGSPAARSGLRAQDR 195
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
++EVN NVEG H +VV I+A E E L V+
Sbjct: 196 LIEVNGQNVEGLRHAEVVASIKAREDEARLLVV 228
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 68.9 bits (167), Expect = 1e-11
Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 13/101 (12%)
Query: 37 GGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADR-AGV 95
G PRVV + K+E G GFN+ G + + ++S ++PGG ADR G+
Sbjct: 87 GHSHPRVVELPKTEEGLGFNIMGGKEQNSPI------------YISRIIPGGIADRHGGL 134
Query: 96 RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136
++GD++L VN V+VEG H++ V+L++A + ++ L V P
Sbjct: 135 KRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTP 175
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 68.6 bits (166), Expect = 1e-11
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 13/101 (12%)
Query: 37 GGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADR-AGV 95
G PRVV + K++ G GFN+ G + + ++S V+PGG ADR G+
Sbjct: 87 GHAHPRVVELPKTDEGLGFNIMGGKEQNSPI------------YISRVIPGGVADRHGGL 134
Query: 96 RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136
++GD++L VN V+VEG H++ V+L++A + + L V P
Sbjct: 135 KRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTP 175
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 66.6 bits (161), Expect = 5e-11
Identities = 35/101 (34%), Positives = 58/101 (57%), Gaps = 13/101 (12%)
Query: 37 GGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADR-AGV 95
G PRVV + K++ G GFNV G + + ++S ++PGG A+R G+
Sbjct: 102 GHSHPRVVELPKTDEGLGFNVMGGKEQNSPI------------YISRIIPGGVAERHGGL 149
Query: 96 RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136
++GD++L VN V+VEG H++ V+L++A + + L V P
Sbjct: 150 KRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTP 190
>gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2
[Homo sapiens]
Length = 281
Score = 65.9 bits (159), Expect = 9e-11
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 4/105 (3%)
Query: 43 VVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRIL 102
VV K G+GF +RG ++ + LQ++ +V GG A +AG+R GD ++
Sbjct: 39 VVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLI 98
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSD 147
EVN+ NV H+QVV++IR G L+L V++V NLDP D
Sbjct: 99 EVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTV----TRNLDPDD 139
>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
[Homo sapiens]
Length = 1849
Score = 65.9 bits (159), Expect = 9e-11
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 4/105 (3%)
Query: 43 VVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRIL 102
VV K G+GF +RG ++ + LQ++ +V GG A +AG+R GD ++
Sbjct: 627 VVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLI 686
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSD 147
EVN+ NV H+QVV++IR G L+L V++V NLDP D
Sbjct: 687 EVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTV----TRNLDPDD 727
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 61.6 bits (148), Expect = 2e-09
Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 13/103 (12%)
Query: 31 AGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAA 90
+ + G PR+ + K +GYGF++ G+ + GQ ++ V PG A
Sbjct: 2 SADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQ-------------YIRLVEPGSPA 48
Query: 91 DRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
++AG+ GDR++EVN NVE TH+QVV IRA + L V+
Sbjct: 49 EKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVV 91
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/93 (38%), Positives = 48/93 (51%), Gaps = 13/93 (13%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+ + K SGYGFN+ S+ GQ + +V P A+ +G+R DR
Sbjct: 152 PRLCTMKKGPSGYGFNLHSDKSKPGQF-------------IRSVDPDSPAEASGLRAQDR 198
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
I+EVN V +EG H VV IRAG E L V+
Sbjct: 199 IVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVV 231
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo
sapiens]
Length = 1747
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/88 (40%), Positives = 50/88 (56%)
Query: 48 KSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHV 107
+ G+GF +RG +E + LQ++ +V G A RAG+R GD ++EVN V
Sbjct: 593 RDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGV 652
Query: 108 NVEGATHKQVVDLIRAGEKELILTVLSV 135
NV HKQVV LIR G L++ V+SV
Sbjct: 653 NVVKVGHKQVVALIRQGGNRLVMKVVSV 680
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo
sapiens]
Length = 2161
Score = 60.1 bits (144), Expect = 5e-09
Identities = 34/91 (37%), Positives = 51/91 (56%)
Query: 48 KSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHV 107
K G+GF +RG ++ + LQ++ +V GG A RAG+R GD ++EVN
Sbjct: 669 KDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQ 728
Query: 108 NVEGATHKQVVDLIRAGEKELILTVLSVPPH 138
NV H+QVV++IR G L++ V+ V H
Sbjct: 729 NVVKVGHRQVVNMIRQGGNTLMVKVVMVTRH 759
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/81 (41%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSI-NGELYAPLQHVSAVLPGGAADRAG-VRKGDRI 101
V + K+++ G +V +GG S+ +G +Y V AV+P GAA+ G + KGDR+
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIY-----VKAVIPQGAAESDGRIHKGDRV 1423
Query: 102 LEVNHVNVEGATHKQVVDLIR 122
L VN V++EGATHKQ V+ +R
Sbjct: 1424 LAVNGVSLEGATHKQAVETLR 1444
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 5/111 (4%)
Query: 56 NVRGQVSEGGQLRSINGELYAPLQ---HVSAVLPGGAADRAGVRK-GDRILEVNHVNVEG 111
N++ G + I GE L +S+V PGG AD G K GDR++ VN V++EG
Sbjct: 1095 NLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEG 1154
Query: 112 ATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQA 162
+H +++++ +++ L V+S P + + + L +Y +K +
Sbjct: 1155 VSHHAAIEILQNAPEDVTL-VISQPKEKISKVPSTPVHLTNEMKNYMKKSS 1204
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 7/102 (6%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V++ K+ SG GF+ + + I ++ A + V + PG A +G + GD IL
Sbjct: 1507 VKLFKNSSGLGFSFSREDN------LIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1560
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLD 144
+VN +++G + ++V+ +R E+ L + PP +D
Sbjct: 1561 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1602
Score = 37.0 bits (84), Expect = 0.045
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 14/91 (15%)
Query: 43 VVRIVKSESG-YGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRI 101
++ ++KSE G GF V ++G Q +V V+ A ++ GDR+
Sbjct: 1793 LITLIKSEKGSLGFTV----TKGNQRIGC---------YVHDVIQDPAKSDGRLKPGDRL 1839
Query: 102 LEVNHVNVEGATHKQVVDLIRAGEKELILTV 132
++VN +V TH V+L+RA K + L +
Sbjct: 1840 IKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1870
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 57.0 bits (136), Expect = 4e-08
Identities = 37/106 (34%), Positives = 55/106 (51%), Gaps = 18/106 (16%)
Query: 34 GGGGGGGPRVVRIV-----KSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGG 88
GG GP VR+V K+ G GF++RG G + +VS V PG
Sbjct: 128 GGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGI------------YVSLVEPGS 175
Query: 89 AADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLS 134
A++ G+R GD+IL VN ++ TH + V ++ G K+L+L+V S
Sbjct: 176 LAEKEGLRVGDQILRVNDKSLARVTHAEAVKALK-GSKKLVLSVYS 220
Score = 43.5 bits (101), Expect = 5e-04
Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 25/150 (16%)
Query: 3 DEDGEGIHPSA--PHRNGGG----GGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFN 56
D G I P + P +GG G S LH GG +V ++ G
Sbjct: 238 DPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQ----GGDEKKVNLVLGDGRSLGLT 293
Query: 57 VRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQ 116
+RG G Y +++ V PG A+ +G++ GD+ILEVN + H +
Sbjct: 294 IRG------------GAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDE 341
Query: 117 VVDLIRAGEKELILTVLSVP--PHEADNLD 144
V L+++ + LILTV V PH +D
Sbjct: 342 AVRLLKS-SRHLILTVKDVGRLPHARTTVD 370
Score = 32.7 bits (73), Expect = 0.84
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 12/80 (15%)
Query: 43 VVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRK-GDRI 101
+VR+ KS + G + G G R PL + + GG+A G K G I
Sbjct: 816 LVRVKKSAATLGIAIEG----GANTRQ-------PLPRIVTIQRGGSAHNCGQLKVGHVI 864
Query: 102 LEVNHVNVEGATHKQVVDLI 121
LEVN + + G H++ +I
Sbjct: 865 LEVNGLTLRGKEHREAARII 884
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 56.6 bits (135), Expect = 5e-08
Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 30/125 (24%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
P++ R+ K E+GYGF+ L +I G P + V GG AD AG+ D
Sbjct: 376 PKLCRLAKGENGYGFH----------LNAIRG---LPGSFIKEVQKGGPADLAGLEDEDV 422
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEK 160
I+EVN VNV +++VVD I++ K + L V G+ YDY +
Sbjct: 423 IIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV-----------------CGKKAYDYFQA 465
Query: 161 QAVPI 165
+ +PI
Sbjct: 466 KKIPI 470
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 16/103 (15%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+V + K +GYGF +R + GQ+ + + G A+ AG++ D
Sbjct: 241 PRIVEMKKGSNGYGFYLRAGSEQKGQI-------------IKDIDSGSPAEEAGLKNNDL 287
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNL 143
++ VN +VE H VV++IR G + T L V E DN+
Sbjct: 288 VVAVNGESVETLDHDSVVEMIRKGGDQ---TSLLVVDKETDNM 327
Score = 48.9 bits (115), Expect = 1e-05
Identities = 30/93 (32%), Positives = 52/93 (55%), Gaps = 14/93 (15%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
PR+ +VK YGF+ L+++ G+ +++ + P G A RAGV D
Sbjct: 133 PRLCYLVKEGGSYGFS----------LKTVQGKKGV---YMTDITPQGVAMRAGVLADDH 179
Query: 101 ILEVNHVNVEGATHKQVVDLI-RAGEKELILTV 132
++EVN NVE A+H++VV+ + ++G + + L V
Sbjct: 180 LIEVNGENVEDASHEEVVEKVKKSGSRVMFLLV 212
Score = 47.0 bits (110), Expect = 4e-05
Identities = 33/100 (33%), Positives = 47/100 (47%), Gaps = 14/100 (14%)
Query: 41 PRVVRIVKSES-GYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGD 99
PR ++ K E YGF +R + G L V V A++AG++ GD
Sbjct: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHL-------------VRVVEKCSPAEKAGLQDGD 53
Query: 100 RILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHE 139
R+L +N V V+ H QVVDL+R + L VL +E
Sbjct: 54 RVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYE 93
>gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo
sapiens]
Length = 227
Score = 56.6 bits (135), Expect = 5e-08
Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 30/125 (24%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
P++ R+ K E+GYGF+ L +I G P + V GG AD AG+ D
Sbjct: 55 PKLCRLAKGENGYGFH----------LNAIRG---LPGSFIKEVQKGGPADLAGLEDEDV 101
Query: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEK 160
I+EVN VNV +++VVD I++ K + L V G+ YDY +
Sbjct: 102 IIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV-----------------CGKKAYDYFQA 144
Query: 161 QAVPI 165
+ +PI
Sbjct: 145 KKIPI 149
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 56.2 bits (134), Expect = 7e-08
Identities = 33/80 (41%), Positives = 50/80 (62%), Gaps = 10/80 (12%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V + K+++ G +V G V+ + +G +Y V AV+P GAA+ G + KGDR+L
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVR----HGGIY-----VKAVIPQGAAESDGRIHKGDRVL 1228
Query: 103 EVNHVNVEGATHKQVVDLIR 122
VN V++EGATHKQ V+ +R
Sbjct: 1229 AVNGVSLEGATHKQAVETLR 1248
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 5/111 (4%)
Query: 56 NVRGQVSEGGQLRSINGELYAPLQ---HVSAVLPGGAADRAGVRK-GDRILEVNHVNVEG 111
N++ G + I GE L +S+V PGG AD G K GDR++ VN V++EG
Sbjct: 904 NLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEG 963
Query: 112 ATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQA 162
+H +++++ +++ L V+S P + + + L +Y +K +
Sbjct: 964 VSHHAAIEILQNAPEDVTL-VISQPKEKISKVPSTPVHLTNEMKNYMKKSS 1013
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 7/102 (6%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V++ K+ SG GF+ + + I ++ A + V + PG A +G + GD IL
Sbjct: 1311 VKLFKNSSGLGFSFSREDN------LIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1364
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLD 144
+VN +++G + ++V+ +R E+ L + PP +D
Sbjct: 1365 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1406
Score = 37.0 bits (84), Expect = 0.045
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 14/91 (15%)
Query: 43 VVRIVKSESG-YGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRI 101
++ ++KSE G GF V ++G Q +V V+ A ++ GDR+
Sbjct: 1597 LITLIKSEKGSLGFTV----TKGNQRIGC---------YVHDVIQDPAKSDGRLKPGDRL 1643
Query: 102 LEVNHVNVEGATHKQVVDLIRAGEKELILTV 132
++VN +V TH V+L+RA K + L +
Sbjct: 1644 IKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1674
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 56.2 bits (134), Expect = 7e-08
Identities = 33/80 (41%), Positives = 50/80 (62%), Gaps = 10/80 (12%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V + K+++ G +V G V+ + +G +Y V AV+P GAA+ G + KGDR+L
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVR----HGGIY-----VKAVIPQGAAESDGRIHKGDRVL 1419
Query: 103 EVNHVNVEGATHKQVVDLIR 122
VN V++EGATHKQ V+ +R
Sbjct: 1420 AVNGVSLEGATHKQAVETLR 1439
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 5/111 (4%)
Query: 56 NVRGQVSEGGQLRSINGELYAPLQ---HVSAVLPGGAADRAGVRK-GDRILEVNHVNVEG 111
N++ G + I GE L +S+V PGG AD G K GDR++ VN V++EG
Sbjct: 1095 NLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEG 1154
Query: 112 ATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQA 162
+H +++++ +++ L V+S P + + + L +Y +K +
Sbjct: 1155 VSHHAAIEILQNAPEDVTL-VISQPKEKISKVPSTPVHLTNEMKNYMKKSS 1204
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 7/102 (6%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V++ K+ SG GF+ + + I ++ A + V + PG A +G + GD IL
Sbjct: 1502 VKLFKNSSGLGFSFSREDN------LIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1555
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLD 144
+VN +++G + ++V+ +R E+ L + PP +D
Sbjct: 1556 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1597
Score = 37.0 bits (84), Expect = 0.045
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 14/91 (15%)
Query: 43 VVRIVKSESG-YGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRI 101
++ ++KSE G GF V ++G Q +V V+ A ++ GDR+
Sbjct: 1788 LITLIKSEKGSLGFTV----TKGNQRIGC---------YVHDVIQDPAKSDGRLKPGDRL 1834
Query: 102 LEVNHVNVEGATHKQVVDLIRAGEKELILTV 132
++VN +V TH V+L+RA K + L +
Sbjct: 1835 IKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1865
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 56.2 bits (134), Expect = 7e-08
Identities = 33/80 (41%), Positives = 50/80 (62%), Gaps = 10/80 (12%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V + K+++ G +V G V+ + +G +Y V AV+P GAA+ G + KGDR+L
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVR----HGGIY-----VKAVIPQGAAESDGRIHKGDRVL 1400
Query: 103 EVNHVNVEGATHKQVVDLIR 122
VN V++EGATHKQ V+ +R
Sbjct: 1401 AVNGVSLEGATHKQAVETLR 1420
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 5/111 (4%)
Query: 56 NVRGQVSEGGQLRSINGELYAPLQ---HVSAVLPGGAADRAGVRK-GDRILEVNHVNVEG 111
N++ G + I GE L +S+V PGG AD G K GDR++ VN V++EG
Sbjct: 1076 NLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEG 1135
Query: 112 ATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQA 162
+H +++++ +++ L V+S P + + + L +Y +K +
Sbjct: 1136 VSHHAAIEILQNAPEDVTL-VISQPKEKISKVPSTPVHLTNEMKNYMKKSS 1185
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 7/102 (6%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V++ K+ SG GF+ + + I ++ A + V + PG A +G + GD IL
Sbjct: 1483 VKLFKNSSGLGFSFSREDN------LIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1536
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLD 144
+VN +++G + ++V+ +R E+ L + PP +D
Sbjct: 1537 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1578
Score = 37.0 bits (84), Expect = 0.045
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 14/91 (15%)
Query: 43 VVRIVKSESG-YGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRI 101
++ ++KSE G GF V ++G Q +V V+ A ++ GDR+
Sbjct: 1769 LITLIKSEKGSLGFTV----TKGNQRIGC---------YVHDVIQDPAKSDGRLKPGDRL 1815
Query: 102 LEVNHVNVEGATHKQVVDLIRAGEKELILTV 132
++VN +V TH V+L+RA K + L +
Sbjct: 1816 IKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1846
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 17/96 (17%)
Query: 42 RVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRI 101
R V I K + G+GF V G + V +V PGGAA +AGV++GDRI
Sbjct: 46 RCVIIQKDQHGFGFTVSGD----------------RIVLVQSVRPGGAAMKAGVKEGDRI 89
Query: 102 LEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPP 137
++VN V ++H +VV LI++G + LT+L P
Sbjct: 90 IKVNGTMVTNSSHLEVVKLIKSG-AYVALTLLGSSP 124
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 17/96 (17%)
Query: 42 RVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRI 101
R V I K + G+GF V G + V +V PGGAA +AGV++GDRI
Sbjct: 46 RCVIIQKDQHGFGFTVSGD----------------RIVLVQSVRPGGAAMKAGVKEGDRI 89
Query: 102 LEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPP 137
++VN V ++H +VV LI++G + LT+L P
Sbjct: 90 IKVNGTMVTNSSHLEVVKLIKSG-AYVALTLLGSSP 124
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/121 (28%), Positives = 62/121 (51%), Gaps = 19/121 (15%)
Query: 32 GNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAAD 91
G G GG R VR+ K +GF +RG +G ++ + +VLPG AD
Sbjct: 268 GGLAGPGGARRTVRVYKGNKSFGFTLRG-----------HGPVW-----IESVLPGSPAD 311
Query: 92 RAGVRKGDRILEVNHVNVEGATHKQVVDLIR-AGEKELILTVLSVPP--HEADNLDPSDD 148
A ++ GDRIL +N +++ +H +VV +++ +G ++ + P ++D+LD +
Sbjct: 312 NAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNP 371
Query: 149 S 149
S
Sbjct: 372 S 372
Score = 32.0 bits (71), Expect = 1.4
Identities = 17/42 (40%), Positives = 25/42 (59%)
Query: 81 VSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIR 122
V V G +A G+R GD+ILEV + V G + +++V L R
Sbjct: 29 VLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLAR 70
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 54.3 bits (129), Expect = 3e-07
Identities = 38/98 (38%), Positives = 50/98 (51%), Gaps = 15/98 (15%)
Query: 35 GGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG 94
GG PR + + K +G GFN+ G G VS +L GG AD +G
Sbjct: 41 GGDAREPRKIILHKGSTGLGFNIVGGEDGEGIF-------------VSFILAGGPADLSG 87
Query: 95 -VRKGDRILEVNHVNVEGATHKQ-VVDLIRAGEKELIL 130
+R+GDRIL VN VN+ ATH+Q L RAG+ I+
Sbjct: 88 ELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 125
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 54.3 bits (129), Expect = 3e-07
Identities = 40/130 (30%), Positives = 60/130 (46%), Gaps = 15/130 (11%)
Query: 25 GSGLHCAGNGGGGGGGPRVVRIV----------KSESGYGFNVRGQVSEGGQLRSINGEL 74
GSG +G G GGGGG VV V G+GF + VS + G
Sbjct: 972 GSG-STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNA 1030
Query: 75 YAPLQH-VSAVLPGGAADRAG-VRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTV 132
+ H + ++ G ADR G ++ GDRIL VN ++ +H +V+LI+ + L +
Sbjct: 1031 CVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1090
Query: 133 LSVPPHEADN 142
+P E+ N
Sbjct: 1091 --IPGDESSN 1098
Score = 43.1 bits (100), Expect = 6e-04
Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 15/90 (16%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILE 103
V IVK G+GF + GGQ V ++ G+++GD I+E
Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQ-------------RVKQIVDSPRC--RGLKEGDLIVE 688
Query: 104 VNHVNVEGATHKQVVDLIRAGEKELILTVL 133
VN NV+ TH QVVD++ K +T+L
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLL 718
Score = 42.0 bits (97), Expect = 0.001
Identities = 31/106 (29%), Positives = 51/106 (48%), Gaps = 17/106 (16%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V + + G+GF++RG R N +LY V + G A+R G +R GD IL
Sbjct: 1153 VELERGAKGFGFSLRGG-------REYNMDLY-----VLRLAEDGPAERCGKMRIGDEIL 1200
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVL----SVPPHEADNLD 144
E+N + H + ++LI+ G + + L + SVP + N +
Sbjct: 1201 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYGGSNYE 1246
Score = 35.0 bits (79), Expect = 0.17
Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 11/79 (13%)
Query: 45 RIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEV 104
++ KS G+GF V G E LQ S VL G AA + GD I+ V
Sbjct: 474 KLRKSSRGFGFTVVG-----------GDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
Query: 105 NHVNVEGATHKQVVDLIRA 123
N V G TH QVV + ++
Sbjct: 523 NDTCVLGHTHAQVVKIFQS 541
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 53.5 bits (127), Expect = 5e-07
Identities = 39/129 (30%), Positives = 58/129 (44%), Gaps = 14/129 (10%)
Query: 25 GSGLHCAGNGGGGGGGPRVVRIV----------KSESGYGFNVRGQVSEGGQLRSINGEL 74
GSG +G G GGGGG VV V G+GF + VS +
Sbjct: 944 GSG-STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNAC 1002
Query: 75 YAPLQHVSAVLPGGAADRAG-VRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
A + ++ G ADR G ++ GDRIL VN ++ +H +V+LI+ + L +
Sbjct: 1003 VAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI- 1061
Query: 134 SVPPHEADN 142
+P E+ N
Sbjct: 1062 -IPGDESSN 1069
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/126 (30%), Positives = 59/126 (46%), Gaps = 26/126 (20%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V + + G+GF++RG R N +LY V + G A+R G +R GD IL
Sbjct: 1124 VELERGAKGFGFSLRGG-------REYNMDLY-----VLRLAEDGPAERCGKMRIGDEIL 1171
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELILTVL----SVPPHEADNLDPSDDSLGQSFYDYT 158
E+N + H + ++LI+ G + + L + SVP + DPS D G + T
Sbjct: 1172 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY-----DPSSDRHGPA----T 1222
Query: 159 EKQAVP 164
Q VP
Sbjct: 1223 GPQGVP 1228
Score = 43.1 bits (100), Expect = 6e-04
Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 15/90 (16%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILE 103
V IVK G+GF + GGQ V ++ G+++GD I+E
Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQ-------------RVKQIVDSPRC--RGLKEGDLIVE 688
Query: 104 VNHVNVEGATHKQVVDLIRAGEKELILTVL 133
VN NV+ TH QVVD++ K +T+L
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLL 718
Score = 35.0 bits (79), Expect = 0.17
Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 11/79 (13%)
Query: 45 RIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEV 104
++ KS G+GF V G E LQ S VL G AA + GD I+ V
Sbjct: 474 KLRKSSRGFGFTVVG-----------GDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
Query: 105 NHVNVEGATHKQVVDLIRA 123
N V G TH QVV + ++
Sbjct: 523 NDTCVLGHTHAQVVKIFQS 541
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 53.5 bits (127), Expect = 5e-07
Identities = 39/129 (30%), Positives = 58/129 (44%), Gaps = 14/129 (10%)
Query: 25 GSGLHCAGNGGGGGGGPRVVRIV----------KSESGYGFNVRGQVSEGGQLRSINGEL 74
GSG +G G GGGGG VV V G+GF + VS +
Sbjct: 972 GSG-STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNAC 1030
Query: 75 YAPLQHVSAVLPGGAADRAG-VRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
A + ++ G ADR G ++ GDRIL VN ++ +H +V+LI+ + L +
Sbjct: 1031 VAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI- 1089
Query: 134 SVPPHEADN 142
+P E+ N
Sbjct: 1090 -IPGDESSN 1097
Score = 43.1 bits (100), Expect = 6e-04
Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 15/90 (16%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILE 103
V IVK G+GF + GGQ V ++ G+++GD I+E
Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQ-------------RVKQIVDSPRC--RGLKEGDLIVE 688
Query: 104 VNHVNVEGATHKQVVDLIRAGEKELILTVL 133
VN NV+ TH QVVD++ K +T+L
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLL 718
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 13/88 (14%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V + + G+GF++RG R N +LY V + G A+R G +R GD IL
Sbjct: 1152 VELERGAKGFGFSLRGG-------REYNMDLY-----VLRLAEDGPAERCGKMRIGDEIL 1199
Query: 103 EVNHVNVEGATHKQVVDLIRAGEKELIL 130
E+N + H + ++LI+ G + + L
Sbjct: 1200 EINGETTKNMKHSRAIELIKNGGRRVRL 1227
Score = 35.0 bits (79), Expect = 0.17
Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 11/79 (13%)
Query: 45 RIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEV 104
++ KS G+GF V G E LQ S VL G AA + GD I+ V
Sbjct: 474 KLRKSSRGFGFTVVG-----------GDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
Query: 105 NHVNVEGATHKQVVDLIRA 123
N V G TH QVV + ++
Sbjct: 523 NDTCVLGHTHAQVVKIFQS 541
>gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo
sapiens]
Length = 1376
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/87 (39%), Positives = 46/87 (52%), Gaps = 18/87 (20%)
Query: 37 GGGGPRV--VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG 94
G PRV V + + +GYGF + GQ AP +S V+ G AD G
Sbjct: 14 GPSPPRVRSVEVARGRAGYGFTLSGQ---------------APCV-LSCVMRGSPADFVG 57
Query: 95 VRKGDRILEVNHVNVEGATHKQVVDLI 121
+R GD+IL VN +NV+ A+H+ VV LI
Sbjct: 58 LRAGDQILAVNEINVKKASHEDVVKLI 84
>gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo
sapiens]
Length = 1447
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/87 (39%), Positives = 46/87 (52%), Gaps = 18/87 (20%)
Query: 37 GGGGPRV--VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG 94
G PRV V + + +GYGF + GQ AP +S V+ G AD G
Sbjct: 14 GPSPPRVRSVEVARGRAGYGFTLSGQ---------------APCV-LSCVMRGSPADFVG 57
Query: 95 VRKGDRILEVNHVNVEGATHKQVVDLI 121
+R GD+IL VN +NV+ A+H+ VV LI
Sbjct: 58 LRAGDQILAVNEINVKKASHEDVVKLI 84
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/92 (39%), Positives = 48/92 (52%), Gaps = 15/92 (16%)
Query: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGD 99
PR + + K +G GFN+ G G VS +L GG AD +G +R+GD
Sbjct: 384 PRKIILHKGSTGLGFNIVGGEDGEGIF-------------VSFILAGGPADLSGELRRGD 430
Query: 100 RILEVNHVNVEGATHKQ-VVDLIRAGEKELIL 130
RIL VN VN+ ATH+Q L RAG+ I+
Sbjct: 431 RILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 8/76 (10%)
Query: 44 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRIL 102
V ++K G GF++ G + G Q + +Y ++ ++ GGAA + G ++ GDR+L
Sbjct: 227 VNLLKGPKGLGFSIAGGI--GNQHIPGDNSIY-----ITKIIEGGAAQKDGRLQIGDRLL 279
Query: 103 EVNHVNVEGATHKQVV 118
VN+ N++ H++ V
Sbjct: 280 AVNNTNLQDVRHEEAV 295
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,518,132
Number of Sequences: 37866
Number of extensions: 1047859
Number of successful extensions: 13371
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 329
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 6653
Number of HSP's gapped (non-prelim): 3160
length of query: 528
length of database: 18,247,518
effective HSP length: 107
effective length of query: 421
effective length of database: 14,195,856
effective search space: 5976455376
effective search space used: 5976455376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.