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Search of human proteins with 31657103
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens]
(546 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens] 1123 0.0
gi|31657101 WD repeat domain 23 isoform 2 [Homo sapiens] 1061 0.0
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 90 5e-18
gi|13376840 WD repeat domain 61 [Homo sapiens] 77 5e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 75 2e-13
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 63 6e-10
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 62 2e-09
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 61 2e-09
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 61 2e-09
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 61 2e-09
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 61 3e-09
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 61 3e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 59 9e-09
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 59 9e-09
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 59 1e-08
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 58 2e-08
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 58 3e-08
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 58 3e-08
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 58 3e-08
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo... 58 3e-08
gi|148727341 serine/threonine kinase receptor associated protein... 57 3e-08
gi|26665869 WD repeat domain 51B [Homo sapiens] 57 3e-08
gi|113865883 WD repeat domain 38 [Homo sapiens] 57 4e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 57 6e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 57 6e-08
gi|55741849 WD repeat domain 22 [Homo sapiens] 56 7e-08
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 56 7e-08
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 56 7e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 56 1e-07
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 55 2e-07
>gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens]
Length = 546
Score = 1124 bits (2906), Expect = 0.0
Identities = 546/546 (100%), Positives = 546/546 (100%)
Query: 1 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG 60
MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
Sbjct: 1 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG 60
Query: 61 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 120
GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
Sbjct: 61 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 120
Query: 121 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 180
GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
Sbjct: 121 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 180
Query: 181 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 240
SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
Sbjct: 181 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 240
Query: 241 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 300
YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
Sbjct: 241 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 300
Query: 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 360
LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
Sbjct: 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 360
Query: 361 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 420
IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
Sbjct: 361 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 420
Query: 421 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 480
KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
Sbjct: 421 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 480
Query: 481 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 540
NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
Sbjct: 481 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 540
Query: 541 PFSSPQ 546
PFSSPQ
Sbjct: 541 PFSSPQ 546
>gi|31657101 WD repeat domain 23 isoform 2 [Homo sapiens]
Length = 520
Score = 1061 bits (2743), Expect = 0.0
Identities = 520/546 (95%), Positives = 520/546 (95%), Gaps = 26/546 (4%)
Query: 1 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG 60
MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQ
Sbjct: 1 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQ---------------- 44
Query: 61 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 120
ALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
Sbjct: 45 ----------ALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL 94
Query: 121 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 180
GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
Sbjct: 95 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY 154
Query: 181 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 240
SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
Sbjct: 155 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 214
Query: 241 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 300
YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
Sbjct: 215 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 274
Query: 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 360
LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
Sbjct: 275 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF 334
Query: 361 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 420
IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
Sbjct: 335 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL 394
Query: 421 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 480
KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
Sbjct: 395 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT 454
Query: 481 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 540
NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
Sbjct: 455 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST 514
Query: 541 PFSSPQ 546
PFSSPQ
Sbjct: 515 PFSSPQ 520
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 90.1 bits (222), Expect = 5e-18
Identities = 82/326 (25%), Positives = 129/326 (39%), Gaps = 92/326 (28%)
Query: 226 FTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGAN 285
F P+G+ + + I + N+YG+ D + L AV + ++DG + +
Sbjct: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG----AVMELHYNTDGSMLFSAST 129
Query: 286 DGCLYVFDREQNRRTLQIESHEDDVN---------------------------------- 311
D + V+D E R +++ H VN
Sbjct: 130 DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT 189
Query: 312 --------AVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDS 363
AV F D S QI+ SGG D KVWD R K + GH D +T +
Sbjct: 190 FQNTYQVLAVTFNDTSDQII-SGGIDNDIKVWDLR-----QNKLTYTMRGHADSVTGLSL 243
Query: 364 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP 423
+ YL+SN+ D T+++WD+R F+ +E R +K+
Sbjct: 244 SSEGSYLLSNAMDNTVRVWDVRPFAPKE--------------------------RCVKI- 276
Query: 424 GDSSLMTYRG--HGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTN 481
++G H L+RC +SP S I +G + V V+D S I+ KL
Sbjct: 277 -------FQGNVHNFEKNLLRCSWSPDGSK----IAAGSADRFVYVWDTTSRRILYKLPG 325
Query: 482 HKACVRDVSWHPFEEKIVSSSWDGNL 507
H + +V++HP E I+S+S D L
Sbjct: 326 HAGSINEVAFHPDEPIIISASSDKRL 351
Score = 33.1 bits (74), Expect = 0.67
Identities = 44/212 (20%), Positives = 75/212 (35%), Gaps = 49/212 (23%)
Query: 303 IESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFID 362
+ HE +V F S L S G D + +W+ D L GH + +
Sbjct: 62 LSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVY----GDCDNYATLKGHSGAVMELH 116
Query: 363 SKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKL 422
D L S S D+T+ +WD S G R L
Sbjct: 117 YNTDGSMLFSASTDKTVAVWD-----SETGERVKR------------------------L 147
Query: 423 PGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNH 482
G +S + ++ R P Q + +G G V ++D+ ++ N
Sbjct: 148 KGHTSFV--------NSCYPARRGP------QLVCTGSDDGTVKLWDIRKKAAIQTFQNT 193
Query: 483 KACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQ 514
V V+++ ++I+S D ++++W RQ
Sbjct: 194 YQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 76.6 bits (187), Expect = 5e-14
Identities = 58/200 (29%), Positives = 95/200 (47%), Gaps = 17/200 (8%)
Query: 186 IFMSACQDQTIRLYDCRYGRFRKFKSIKARDV-GWSVLDVAFTPDGNHFLYSSWSDYIHI 244
I S+ D IRL+D G+ + KSI A V W++ AF+PD Y + ++
Sbjct: 78 IAASSSLDAHIRLWDLENGK--QIKSIDAGPVDAWTL---AFSPDSQ---YLATGTHVGK 129
Query: 245 CNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIE 304
NI+G L D R + SIA S DG+ + GA DG + +FD + +E
Sbjct: 130 VNIFGVESGKKEYSL--DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE 187
Query: 305 SHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSK 364
H + ++ F+ SQ+L + DD K++D G L+GH + +
Sbjct: 188 GHAMPIRSLTFSP-DSQLLVTASDDGYIKIYD-----VQHANLAGTLSGHASWVLNVAFC 241
Query: 365 GDARYLISNSKDQTIKLWDI 384
D + +S+S D+++K+WD+
Sbjct: 242 PDDTHFVSSSSDKSVKVWDV 261
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/253 (22%), Positives = 104/253 (41%), Gaps = 48/253 (18%)
Query: 302 QIESHEDDVNAVAFADI---SSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGI 358
Q ++H+D + +VA+ +S+ + +G D + KVW R R D +L GHQ G+
Sbjct: 11 QEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQ---WSLEGHQLGV 67
Query: 359 TFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEA-------------SRQAAT---- 401
+D S+S D I+LWD+ + ++A S+ AT
Sbjct: 68 VSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHV 127
Query: 402 -------------QQNWDYRWQQVPKKAWR-------KLKLPGDSSLMTYRGHGVLHTLI 441
+ + D R + + A+ + G ++ +LHTL
Sbjct: 128 GKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL- 186
Query: 442 RCRFSPIHST----GQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEK 497
PI S Q + + G + +YD+ ++ L+ H + V +V++ P +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 498 IVSSSWDGNLRLW 510
VSSS D ++++W
Sbjct: 247 FVSSSSDKSVKVW 259
Score = 45.4 bits (106), Expect = 1e-04
Identities = 29/114 (25%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWS 239
+S D Q+ ++A D I++YD ++ S A W VL+VAF PD HF+ SS
Sbjct: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA---SW-VLNVAFCPDDTHFVSSSSD 253
Query: 240 DYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFD 293
+ + ++ HT D + V+ + + +G +++ +D ++++D
Sbjct: 254 KSVKVWDVGTRTCVHTFFD-----HQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 34.3 bits (77), Expect = 0.30
Identities = 35/157 (22%), Positives = 62/157 (39%), Gaps = 10/157 (6%)
Query: 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWS 239
YS DG+ S D I ++D G+ +++ + + F+PD + +S
Sbjct: 156 YSPDGKYLASGAIDGIINIFDIATGKL--LHTLEGH--AMPIRSLTFSPDSQLLVTASDD 211
Query: 240 DYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
YI I ++ H L V ++A D + ++D + V+D
Sbjct: 212 GYIKIYDV-----QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTC 266
Query: 300 TLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWD 336
H+D V V + S+I+ S GDD ++D
Sbjct: 267 VHTFFDHQDQVWGVKYNGNGSKIV-SVGDDQEIHIYD 302
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 75.1 bits (183), Expect = 2e-13
Identities = 73/339 (21%), Positives = 128/339 (37%), Gaps = 111/339 (32%)
Query: 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWS 239
+S D +SA D+T++L+D R G+ K++K S
Sbjct: 91 WSSDSSRLVSASDDKTLKLWDVRSGKC--LKTLKGH-----------------------S 125
Query: 240 DYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
+Y+ CN + ++ G+ D + +++ + +
Sbjct: 126 NYVFCCNF--------------------------NPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 300 TLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAG 353
+ +H D V+AV F + S ++ SG D +C++WD +T+ +DD PV
Sbjct: 160 LKTLSAHSDPVSAVHF-NCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV----- 213
Query: 354 HQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVP 413
+F+ + +Y+++ + D T+KLWD R
Sbjct: 214 -----SFVKFSPNGKYILTATLDNTLKLWDYSR--------------------------- 241
Query: 414 KKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSG 473
L TY GH C F+ TG ++I SG V +++L +
Sbjct: 242 -----------GRCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 287
Query: 474 HIVKKLTNHKACVRDVSWHPFEEKIVSSSW--DGNLRLW 510
IV+KL H V + HP E I S++ D ++LW
Sbjct: 288 EIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 50.8 bits (120), Expect = 3e-06
Identities = 50/205 (24%), Positives = 80/205 (39%), Gaps = 50/205 (24%)
Query: 306 HEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKG 365
H + V++V F+ + + L S D + +W D K L GH I+ +
Sbjct: 40 HTEAVSSVKFSP-NGEWLASSSADRLIIIWGAY-----DGKYEKTLYGHNLEISDVAWSS 93
Query: 366 DARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGD 425
D+ L+S S D+T+KLWD+R
Sbjct: 94 DSSRLVSASDDKTLKLWDVR--------------------------------------SG 115
Query: 426 SSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKAC 485
L T +GH + + C F+P I SG V ++++ +G +K L+ H
Sbjct: 116 KCLKTLKGHS--NYVFCCNFNP----PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDP 169
Query: 486 VRDVSWHPFEEKIVSSSWDGNLRLW 510
V V ++ IVS S+DG R+W
Sbjct: 170 VSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 46.6 bits (109), Expect = 6e-05
Identities = 48/217 (22%), Positives = 93/217 (42%), Gaps = 19/217 (8%)
Query: 171 YSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDG 230
+S FC ++ + +S D+T+++++ + G+ K S + V V F G
Sbjct: 124 HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVS----AVHFNCSG 179
Query: 231 NHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLY 290
+ + S Y +C I+ + + L D+ V + S +G+ +L D L
Sbjct: 180 SLIVSGS---YDGLCRIW-DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLK 235
Query: 291 VFDREQNRRTLQIESHEDDVNAVAFADIS---SQILFSGGDDAICKVWDRRTMREDDPKP 347
++D + R H+++ + FA+ S + + SG +D + +W+ +T +
Sbjct: 236 LWDYSRGRCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQT-----KEI 289
Query: 348 VGALAGHQDGITFIDSKGDARYLISNS--KDQTIKLW 382
V L GH D + + S + D+TIKLW
Sbjct: 290 VQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 37.4 bits (85), Expect = 0.036
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 444 RFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSW 503
+FSP +++ S + ++++ G K L H + DV+W ++VS+S
Sbjct: 48 KFSP----NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 504 DGNLRLWQYRQAE 516
D L+LW R +
Sbjct: 104 DKTLKLWDVRSGK 116
Score = 30.8 bits (68), Expect = 3.3
Identities = 13/47 (27%), Positives = 27/47 (57%)
Query: 467 VYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
++D+ SG +K L H V +++P I+S S+D +++W+ +
Sbjct: 109 LWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/306 (21%), Positives = 120/306 (39%), Gaps = 35/306 (11%)
Query: 226 FTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRF----AVFSIAVSSDGREVL 281
F+PDG + + S +I + N + G L + + AV + S D +
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWN-FTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLA 280
Query: 282 GGANDGCLYVFDREQNRRTLQIE-SHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTM 340
GA DG + V+ + + + E +H V ++F+ SSQIL + D I R
Sbjct: 281 TGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI------RIH 334
Query: 341 REDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAA 400
K + GH + D Y+IS S D T+K+W+++ ++ A
Sbjct: 335 GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA 394
Query: 401 TQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVL-----------HTLIRCRFSP-- 447
+PK + ++++ G + + C SP
Sbjct: 395 GTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG 454
Query: 448 --IHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDG 505
I+ G+ F+ + + ++G + + LT H+ V ++ HP + I + S DG
Sbjct: 455 EWIYCVGEDFV--------LYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDG 506
Query: 506 NLRLWQ 511
L+LW+
Sbjct: 507 LLKLWK 512
Score = 37.4 bits (85), Expect = 0.036
Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 167 FTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAF 226
F ++S+ C +SKD +SA DQTIR++ + G+ K + R V + F
Sbjct: 302 FERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLK----EFRGHSSFVNEATF 357
Query: 227 TPDGNHFLYSSWSDYIHICNI 247
T DG++ + +S + I N+
Sbjct: 358 TQDGHYIISASSDGTVKIWNM 378
Score = 32.7 bits (73), Expect = 0.88
Identities = 20/82 (24%), Positives = 35/82 (42%), Gaps = 9/82 (10%)
Query: 444 RFSPIHSTG---------QQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPF 494
RF HS G I S + ++ L SG +K+ H + V + ++
Sbjct: 301 RFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD 360
Query: 495 EEKIVSSSWDGNLRLWQYRQAE 516
I+S+S DG +++W + E
Sbjct: 361 GHYIISASSDGTVKIWNMKTTE 382
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 61.6 bits (148), Expect = 2e-09
Identities = 57/250 (22%), Positives = 93/250 (37%), Gaps = 51/250 (20%)
Query: 271 IAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDA 330
IAV + + G+ D + ++D + L + H V V S LFS G+D
Sbjct: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV-IVSTRSPYLFSCGEDK 268
Query: 331 ICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSR 390
K WD + K + GH + +D L++ S+D T ++WD+R
Sbjct: 269 QVKCWDL-----EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT---- 319
Query: 391 EGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHS 450
+S+ T GH +RC+
Sbjct: 320 ----------------------------------KASVHTLSGHTNAVATVRCQ------ 339
Query: 451 TGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
+ I +G + ++DL++G LTNHK VR V HP S S D N++ W
Sbjct: 340 AAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQW 398
Query: 511 QYRQAEYFQD 520
++ + Q+
Sbjct: 399 KFPDGSFIQN 408
Score = 39.7 bits (91), Expect = 0.007
Identities = 35/163 (21%), Positives = 61/163 (37%), Gaps = 44/163 (26%)
Query: 351 LAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQ 410
++GH + I + ++ ++ S D+TIK+WD+
Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL-------------------------- 233
Query: 411 QVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDL 470
A KLKL + T RG I ST +++S +V +DL
Sbjct: 234 -----ASGKLKLSLTGHISTVRG-------------VIVSTRSPYLFSCGEDKQVKCWDL 275
Query: 471 LSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
+++ H + V + HP + +V+ S D R+W R
Sbjct: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 61.2 bits (147), Expect = 2e-09
Identities = 54/237 (22%), Positives = 90/237 (37%), Gaps = 52/237 (21%)
Query: 275 SDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKV 334
+ GR + G +D + ++ + + + H V +V + +++ +G +V
Sbjct: 31 ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL-NTPEELIVAGSQSGSIRV 89
Query: 335 WDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGME 394
WD K + L GH+ I +D ++ S S+D IKLWDIRR
Sbjct: 90 WDLEAA-----KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR-------- 136
Query: 395 ASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRC-RFSPIHSTGQ 453
+ YRGH +RC RFSP
Sbjct: 137 ------------------------------KGCVFRYRGHS---QAVRCLRFSP----DG 159
Query: 454 QFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
+++ S V ++DL +G ++ + H V V +HP E + S S D +R W
Sbjct: 160 KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 52.8 bits (125), Expect = 8e-07
Identities = 25/73 (34%), Positives = 43/73 (58%), Gaps = 4/73 (5%)
Query: 446 SPIHS----TGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSS 501
SP+ S T ++ I +G +G + V+DL + I++ L HKA + + +HP+ E + S
Sbjct: 64 SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123
Query: 502 SWDGNLRLWQYRQ 514
S D N++LW R+
Sbjct: 124 SQDTNIKLWDIRR 136
Score = 38.1 bits (87), Expect = 0.021
Identities = 40/179 (22%), Positives = 71/179 (39%), Gaps = 17/179 (9%)
Query: 185 QIFMSACQDQTIRLYDCRYGRF-RKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIH 243
++ ++ Q +IR++D + R KA ++ + F P G S I
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKA-----NICSLDFHPYGEFVASGSQDTNIK 130
Query: 244 ICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQI 303
+ +I +G R AV + S DG+ + A+D + ++D + +
Sbjct: 131 LWDIRRKGCV-----FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 304 ESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMR-----EDDPKPVGALAGHQDG 357
H VN V F + +L SG D + WD + E +P PV ++ + DG
Sbjct: 186 PGHTGPVNVVEFHP-NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
Score = 31.2 bits (69), Expect = 2.5
Identities = 16/63 (25%), Positives = 32/63 (50%)
Query: 454 QFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
+ + +G +V ++ + + + LT H + V V + EE IV+ S G++R+W
Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 514 QAE 516
A+
Sbjct: 94 AAK 96
Score = 29.3 bits (64), Expect = 9.7
Identities = 13/35 (37%), Positives = 20/35 (57%)
Query: 171 YSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGR 205
+SQ C +S DG+ SA D T++L+D G+
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 61.2 bits (147), Expect = 2e-09
Identities = 49/211 (23%), Positives = 82/211 (38%), Gaps = 28/211 (13%)
Query: 179 IYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGN------- 231
++ G+ + C D++ RL+D + + + V D+AF DG+
Sbjct: 330 MWHPSGRFLGTTCYDRSWRLWDLE----AQEEILHQEGHSMGVYDIAFHQDGSLAGTGGL 385
Query: 232 HFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYV 291
W C ++ EG ++ I S +G + G+ D V
Sbjct: 386 DAFGRVWDLRTGRCIMFLEGHLKE------------IYGINFSPNGYHIATGSGDNTCKV 433
Query: 292 FDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGAL 351
+D Q R I +H++ V V F I L +G D K+W P+ L
Sbjct: 434 WDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGW-----SPLKTL 488
Query: 352 AGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
AGH+ + +D D + + + S D+T KLW
Sbjct: 489 AGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 45.4 bits (106), Expect = 1e-04
Identities = 53/220 (24%), Positives = 83/220 (37%), Gaps = 49/220 (22%)
Query: 291 VFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGA 350
++D E L E H V +AF S + +GG DA +VWD RT R +
Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDLRTGR-----CIMF 402
Query: 351 LAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQ 410
L GH I I+ + ++ + S D T K+WD+R Q+ Y
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR----------------QRRCVY--- 443
Query: 411 QVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDL 470
+P +L+T GV +F PIH F+ +G ++
Sbjct: 444 ----------TIPAHQNLVT----GV-------KFEPIHG---NFLLTGAYDNTAKIWTH 479
Query: 471 LSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
+K L H+ V + + I + S+D +LW
Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 34.3 bits (77), Expect = 0.30
Identities = 48/231 (20%), Positives = 81/231 (35%), Gaps = 41/231 (17%)
Query: 303 IESHEDDVNAVAF-------ADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQ 355
+ H +V A+ F D L S D K+W D +PV + GH
Sbjct: 269 LRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSL-----DSDEPVADIEGHT 323
Query: 356 DGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQN-----WDYRWQ 410
+ + R+L + D++ +LWD +EA + Q+ +D +
Sbjct: 324 VRVARVMWHPSGRFLGTTCYDRSWRLWD---------LEAQEEILHQEGHSMGVYDIAFH 374
Query: 411 QVPKKA--------WRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCST 462
Q A R L +M GH L + FSP I +G
Sbjct: 375 QDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH--LKEIYGINFSP----NGYHIATGSGD 428
Query: 463 GKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEK-IVSSSWDGNLRLWQY 512
V+DL V + H+ V V + P +++ ++D ++W +
Sbjct: 429 NTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479
Score = 32.7 bits (73), Expect = 0.88
Identities = 26/104 (25%), Positives = 43/104 (41%), Gaps = 5/104 (4%)
Query: 415 KAWRKLKLPGDSSLMTYRGHGV-LHTLIRCRFSPIHSTGQQFIYSGCST-GKVVVYDLLS 472
K W +P + L T RGH + ++ S + + + C+ G V ++ L S
Sbjct: 256 KLW---SVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDS 312
Query: 473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAE 516
V + H V V WHP + ++ +D + RLW E
Sbjct: 313 DEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE 356
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 61.2 bits (147), Expect = 2e-09
Identities = 67/308 (21%), Positives = 128/308 (41%), Gaps = 27/308 (8%)
Query: 220 SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGRE 279
+V+ VAF+P G + S + ++ E T R V SI+ S DGR+
Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKG-----HRHWVLSISWSPDGRK 170
Query: 280 VLGGANDGCLYVFDREQNRRTLQ-IESHEDDVNAVAF----ADISSQILFSGGDDAICKV 334
+ G +G + ++D ++ + + H + +++ A+ + + S D ++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
Query: 335 WDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGME 394
WD R + L GH +T + GD L S S+D+TIK+W + +G+
Sbjct: 231 WDTTAGRCER-----ILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW-----RAHDGV- 278
Query: 395 ASRQAATQQNWDYRWQQVPKKAWRKLKL-PGDSSLMTYRGHGVLHTLIR---CRFSPIHS 450
R +W A R P ++S+ G L L R++ +
Sbjct: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
Query: 451 TGQQFIYSGCSTGKVVVYDLLSGHI-VKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRL 509
G + + SG + ++ + ++T H+A + V + P + S+S+D +++L
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKL 398
Query: 510 WQYRQAEY 517
W R +Y
Sbjct: 399 WDGRTGKY 406
Score = 57.8 bits (138), Expect = 3e-08
Identities = 34/124 (27%), Positives = 66/124 (53%), Gaps = 7/124 (5%)
Query: 263 ERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTL-QIESHEDDVNAVAFADISSQ 321
ER + +++ ++ G++D L+++ ++++ L ++ H+ +N V F+ S+
Sbjct: 327 ERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSR 385
Query: 322 ILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 381
I+ S D K+WD RT K + +L GH + I D+R L+S S D T+K+
Sbjct: 386 IVASASFDKSIKLWDGRT-----GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKV 440
Query: 382 WDIR 385
WD++
Sbjct: 441 WDVK 444
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/218 (23%), Positives = 79/218 (36%), Gaps = 45/218 (20%)
Query: 294 REQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAG 353
R R T +E H + V +VAF+ + + L SG D + WD T P G
Sbjct: 101 RAVTRCTSSLEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLST-----ETPHFTCKG 154
Query: 354 HQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVP 413
H+ + I D R L S K+ I LWD G + R A W +
Sbjct: 155 HRHWVLSISWSPDGRKLASGCKNGQILLWD-----PSTGKQVGRTLAGHSKW------IT 203
Query: 414 KKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSG 473
+W LH CR ++ S G V ++D +G
Sbjct: 204 GLSWEP-----------------LHANPECR----------YVASSSKDGSVRIWDTTAG 236
Query: 474 HIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQ 511
+ LT H V + W + + S+S D +++W+
Sbjct: 237 RCERILTGHTQSVTCLRWGG-DGLLYSASQDRTIKVWR 273
Score = 49.7 bits (117), Expect = 7e-06
Identities = 45/189 (23%), Positives = 69/189 (36%), Gaps = 48/189 (25%)
Query: 323 LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
L SG DD +W +D KP+ + GHQ I + D+R + S S D++IKLW
Sbjct: 344 LVSGSDDFTLFLWSPA----EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
Query: 383 DIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIR 442
D R L + RGH +
Sbjct: 400 DGRT--------------------------------------GKYLASLRGH------VA 415
Query: 443 CRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSS 502
+ S + + SG S + V+D+ + + L H V V W P +++ S
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475
Query: 503 WDGNLRLWQ 511
D LR+W+
Sbjct: 476 KDKCLRIWR 484
Score = 47.4 bits (111), Expect = 3e-05
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)
Query: 271 IAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDA 330
+ S D R V + D + ++D + + H V +A++ S++L SG D+
Sbjct: 378 VLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS-ADSRLLVSGSSDS 436
Query: 331 ICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
KVWD + K L GH D + +D D + + S KD+ +++W
Sbjct: 437 TLKVWDVKAQ-----KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 45.8 bits (107), Expect = 1e-04
Identities = 24/71 (33%), Positives = 41/71 (57%), Gaps = 1/71 (1%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
AV+ IA S+D R ++ G++D L V+D + + + + H D+V AV ++ Q + SG
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSP-DGQRVASG 474
Query: 327 GDDAICKVWDR 337
G D ++W R
Sbjct: 475 GKDKCLRIWRR 485
Score = 39.3 bits (90), Expect = 0.009
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 179 IYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSW 238
++S D +I SA D++I+L+D R G++ S++ +V +A++ D + S
Sbjct: 379 LFSPDSRIVASASFDKSIKLWDGRTGKY--LASLRGHVA--AVYQIAWSADSRLLVSGSS 434
Query: 239 SDYIHICNIYGEGDTHTALDL--RPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDR 294
+ + ++ + A+DL DE V+++ S DG+ V G D CL ++ R
Sbjct: 435 DSTLKVWDVKAQ---KLAMDLPGHADE----VYAVDWSPDGQRVASGGKDKCLRIWRR 485
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 60.8 bits (146), Expect = 3e-09
Identities = 74/315 (23%), Positives = 126/315 (40%), Gaps = 21/315 (6%)
Query: 210 KSIKARDVGW-SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAV 268
K +K D G +V V F DGN+ L + + N L + V
Sbjct: 16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN-----PLRGTLLRTYSGHGYEV 70
Query: 269 FSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGD 328
A S D + G D + ++D + + H VN V F + ++ IL SG
Sbjct: 71 LDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVIL-SGSI 129
Query: 329 DAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFS 388
D+ + WD R+ R P+PV L +DG++ + K +++ S D ++ +D+R
Sbjct: 130 DSSIRCWDCRSRR---PEPVQTLDEARDGVSSV--KVSDHEILAGSVDGRVRRYDLRMGQ 184
Query: 389 SREGMEASRQAATQQNWDYRWQQVPK--KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFS 446
S T + D + V R L L Y+GH + C S
Sbjct: 185 LFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLS 244
Query: 447 PIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGN 506
+ + S GKV +DL+ G + L V+ +++HP E ++ ++ G+
Sbjct: 245 ERDT----HVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLL-TAMGGS 299
Query: 507 LRLWQYRQAEYFQDD 521
++ W R+ Y +D
Sbjct: 300 VQCW--REEAYEAED 312
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 60.8 bits (146), Expect = 3e-09
Identities = 74/315 (23%), Positives = 126/315 (40%), Gaps = 21/315 (6%)
Query: 210 KSIKARDVGW-SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAV 268
K +K D G +V V F DGN+ L + + N L + V
Sbjct: 16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN-----PLRGTLLRTYSGHGYEV 70
Query: 269 FSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGD 328
A S D + G D + ++D + + H VN V F + ++ IL SG
Sbjct: 71 LDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVIL-SGSI 129
Query: 329 DAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFS 388
D+ + WD R+ R P+PV L +DG++ + K +++ S D ++ +D+R
Sbjct: 130 DSSIRCWDCRSRR---PEPVQTLDEARDGVSSV--KVSDHEILAGSVDGRVRRYDLRMGQ 184
Query: 389 SREGMEASRQAATQQNWDYRWQQVPK--KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFS 446
S T + D + V R L L Y+GH + C S
Sbjct: 185 LFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLS 244
Query: 447 PIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGN 506
+ + S GKV +DL+ G + L V+ +++HP E ++ ++ G+
Sbjct: 245 ERDT----HVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLL-TAMGGS 299
Query: 507 LRLWQYRQAEYFQDD 521
++ W R+ Y +D
Sbjct: 300 VQCW--REEAYEAED 312
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 59.3 bits (142), Expect = 9e-09
Identities = 54/249 (21%), Positives = 99/249 (39%), Gaps = 16/249 (6%)
Query: 265 RFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILF 324
R AV + S + +++ G+ D CL V+ + R + H+D V V F+ S +L
Sbjct: 19 RDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLLA 77
Query: 325 SGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDI 384
SG D ++W E H + + D + ++ S D+T+K+W
Sbjct: 78 SGSRDKTVRIWVPNVKGEST-----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 385 RR----FSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTL 440
R FS + + R A + K + + +Y HG T
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192
Query: 441 IRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVS 500
+ H +G +G V V+D+ + +++ H A V +S+HP +++
Sbjct: 193 V-----DFHPSGTCIAAAGMD-NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 501 SSWDGNLRL 509
+S D L++
Sbjct: 247 ASSDSTLKI 255
Score = 45.4 bits (106), Expect = 1e-04
Identities = 53/208 (25%), Positives = 91/208 (43%), Gaps = 15/208 (7%)
Query: 177 CGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYS 236
C +S G + S +D+T+R++ K +S R +V V F DG F+ +
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNV----KGESTVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 237 SWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQ 296
S + + + + + L + R A FS DGR ++ ++D + ++D+
Sbjct: 122 SDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFS----PDGRLIVSASDDKTVKLWDKSS 176
Query: 297 NRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQD 356
H V V F + I +G D+ + KVWD RT R + + A +
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV-KVWDVRTHRLLQHYQLHSAA--VN 233
Query: 357 GITFIDSKGDARYLISNSKDQTIKLWDI 384
G++F S YLI+ S D T+K+ D+
Sbjct: 234 GLSFHPS---GNYLITASSDSTLKILDL 258
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/199 (22%), Positives = 74/199 (37%), Gaps = 36/199 (18%)
Query: 177 CGIYSKDGQIFMSACQDQTIRLYD----------CRYGRFRKFKSIKARDVGWSVLDVAF 226
C +S DG++ +SA D+T++L+D C +G F V V F
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF--------------VTYVDF 195
Query: 227 TPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGAND 286
P G + + + + ++ TH L AV ++ G ++ ++D
Sbjct: 196 HPSGTCIAAAGMDNTVKVWDV----RTHRLLQ-HYQLHSAAVNGLSFHPSGNYLITASSD 250
Query: 287 GCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDD-- 344
L + D + R + H+ VAF+ + + SGG D VW D
Sbjct: 251 STLKILDLMEGRLLYTLHGHQGPATTVAFSR-TGEYFASGGSDEQVMVWKSNFDIVDHGE 309
Query: 345 ----PKPVGALAGHQDGIT 359
P+P LA +T
Sbjct: 310 VTKVPRPPATLASSMGNLT 328
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/239 (20%), Positives = 91/239 (38%), Gaps = 26/239 (10%)
Query: 151 GEQSRVISHFLPNDLG-------FTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRY 203
G + + + ++PN G T + FC DGQ F++A D+T++++
Sbjct: 79 GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS----DGQSFVTASDDKTVKVWATHR 134
Query: 204 GRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDE 263
+KF ++ + W V F+PDG + +S + + + H+ E
Sbjct: 135 ---QKFLFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC-----E 185
Query: 264 RRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQIL 323
V + G + D + V+D +R + H VN ++F S L
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYL 244
Query: 324 FSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
+ D+ K+ D + + + L GHQ T + Y S D+ + +W
Sbjct: 245 ITASSDSTLKILDLM-----EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 38.9 bits (89), Expect = 0.012
Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 16/181 (8%)
Query: 343 DDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQ 402
+DP GH+D +T +D + + L S S D + +W ++ S + A T
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 403 QNWDYRWQQVPKKAWRKL------KLPGDSSLMTYRGH-GVLHTLIRCRFSPIHSTGQQF 455
N+ + + K + G+S++ +R H + ++ C S GQ F
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFC------SDGQSF 118
Query: 456 IYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQA 515
+ + V V+ + L+ H VR + P IVS+S D ++LW
Sbjct: 119 V-TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 516 E 516
E
Sbjct: 178 E 178
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 59.3 bits (142), Expect = 9e-09
Identities = 54/249 (21%), Positives = 99/249 (39%), Gaps = 16/249 (6%)
Query: 265 RFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILF 324
R AV + S + +++ G+ D CL V+ + R + H+D V V F+ S +L
Sbjct: 19 RDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP-SGHLLA 77
Query: 325 SGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDI 384
SG D ++W E H + + D + ++ S D+T+K+W
Sbjct: 78 SGSRDKTVRIWVPNVKGEST-----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 385 RR----FSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTL 440
R FS + + R A + K + + +Y HG T
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192
Query: 441 IRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVS 500
+ H +G +G V V+D+ + +++ H A V +S+HP +++
Sbjct: 193 V-----DFHPSGTCIAAAGMD-NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 501 SSWDGNLRL 509
+S D L++
Sbjct: 247 ASSDSTLKI 255
Score = 45.4 bits (106), Expect = 1e-04
Identities = 53/208 (25%), Positives = 91/208 (43%), Gaps = 15/208 (7%)
Query: 177 CGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYS 236
C +S G + S +D+T+R++ K +S R +V V F DG F+ +
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNV----KGESTVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 237 SWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQ 296
S + + + + + L + R A FS DGR ++ ++D + ++D+
Sbjct: 122 SDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFS----PDGRLIVSASDDKTVKLWDKSS 176
Query: 297 NRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQD 356
H V V F + I +G D+ + KVWD RT R + + A +
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV-KVWDVRTHRLLQHYQLHSAA--VN 233
Query: 357 GITFIDSKGDARYLISNSKDQTIKLWDI 384
G++F S YLI+ S D T+K+ D+
Sbjct: 234 GLSFHPS---GNYLITASSDSTLKILDL 258
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/202 (21%), Positives = 75/202 (37%), Gaps = 36/202 (17%)
Query: 177 CGIYSKDGQIFMSACQDQTIRLYD----------CRYGRFRKFKSIKARDVGWSVLDVAF 226
C +S DG++ +SA D+T++L+D C +G F V V F
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF--------------VTYVDF 195
Query: 227 TPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGAND 286
P G + + + + ++ TH L AV ++ G ++ ++D
Sbjct: 196 HPSGTCIAAAGMDNTVKVWDV----RTHRLLQ-HYQLHSAAVNGLSFHPSGNYLITASSD 250
Query: 287 GCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDD-- 344
L + D + R + H+ VAF+ + + SGG D VW D
Sbjct: 251 STLKILDLMEGRLLYTLHGHQGPATTVAFSR-TGEYFASGGSDEQVMVWKSNFDIVDHGE 309
Query: 345 ----PKPVGALAGHQDGITFID 362
P+P LA + +D
Sbjct: 310 VTKVPRPPATLASSMGNLPEVD 331
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/239 (20%), Positives = 91/239 (38%), Gaps = 26/239 (10%)
Query: 151 GEQSRVISHFLPNDLG-------FTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRY 203
G + + + ++PN G T + FC DGQ F++A D+T++++
Sbjct: 79 GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS----DGQSFVTASDDKTVKVWATHR 134
Query: 204 GRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDE 263
+KF ++ + W V F+PDG + +S + + + H+ E
Sbjct: 135 ---QKFLFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC-----E 185
Query: 264 RRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQIL 323
V + G + D + V+D +R + H VN ++F S L
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYL 244
Query: 324 FSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
+ D+ K+ D + + + L GHQ T + Y S D+ + +W
Sbjct: 245 ITASSDSTLKILDLM-----EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 38.9 bits (89), Expect = 0.012
Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 16/181 (8%)
Query: 343 DDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQ 402
+DP GH+D +T +D + + L S S D + +W ++ S + A T
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 403 QNWDYRWQQVPKKAWRKL------KLPGDSSLMTYRGH-GVLHTLIRCRFSPIHSTGQQF 455
N+ + + K + G+S++ +R H + ++ C S GQ F
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFC------SDGQSF 118
Query: 456 IYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQA 515
+ + V V+ + L+ H VR + P IVS+S D ++LW
Sbjct: 119 V-TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 516 E 516
E
Sbjct: 178 E 178
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 58.5 bits (140), Expect = 1e-08
Identities = 75/310 (24%), Positives = 127/310 (40%), Gaps = 27/310 (8%)
Query: 220 SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGRE 279
+V V F+P + + S IHI Y + T + + DGR
Sbjct: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKD-----TAYCATFRQDGRL 94
Query: 280 VLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRT 339
++ G+ DG + +FD Q E H V+ V F ++ SG DD K+WD
Sbjct: 95 LVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVV-SGADDYTVKLWDIPN 153
Query: 340 MREDDPKPVGALAGHQDGITF-IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQ 398
+E + H D + SK + I+ S D T+K++D R S +E +
Sbjct: 154 SKE-----ILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQP 208
Query: 399 AATQQNWDYRWQQVPK-----KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQ 453
+ + V K W LK G L++ + H H + C + S+GQ
Sbjct: 209 VESVLLFPSGGLLVSAGGRYVKVWDMLK--GGQLLVSLKNH---HKTVTCLC--LSSSGQ 261
Query: 454 QFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
+ + SG KV VY S +V ++ A + ++ +E IV +G L + ++R
Sbjct: 262 RLL-SGSLDRKVKVYSTTSYKVVHSF-DYAASILSLALAHEDETIVVGMTNGILSV-KHR 318
Query: 514 QAEYFQDDMP 523
++E ++ +P
Sbjct: 319 KSEAKKESLP 328
Score = 37.0 bits (84), Expect = 0.046
Identities = 43/214 (20%), Positives = 88/214 (41%), Gaps = 19/214 (8%)
Query: 171 YSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGR--FRKFKSIKARDVGWSVLDVAFTP 228
+ A+C + +DG++ ++ +D ++L+D GR R+F+ +V V FT
Sbjct: 79 FKDTAYCATFRQDGRLLVAGSEDGGVQLFDIS-GRAPLRQFEGHTK-----AVHTVDFTA 132
Query: 229 DGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGC 288
D H + + + + +I + T + + A + + G+ D
Sbjct: 133 DKYHVVSGADDYTVKLWDIPNSKEILTF----KEHSDYVRCGCASKLNPDLFITGSYDHT 188
Query: 289 LYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPV 348
+ +FD + L +E H V +V ++ +GG KVWD + +
Sbjct: 189 VKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG--RYVKVWDML----KGGQLL 241
Query: 349 GALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
+L H +T + + L+S S D+ +K++
Sbjct: 242 VSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 58.2 bits (139), Expect = 2e-08
Identities = 57/245 (23%), Positives = 105/245 (42%), Gaps = 27/245 (11%)
Query: 142 LCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDC 201
+C S E + +S LP G+ C + D QI S+ D T L+D
Sbjct: 120 ICSIYSLKTREGNVRVSRELPGHTGYLS-------CCRFLDDNQIITSS-GDTTCALWDI 171
Query: 202 RYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRP 261
G+ +++ V+ ++ PDG F+ + I + ++ T +
Sbjct: 172 ETGQ----QTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES 227
Query: 262 DERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHED---DVNAVAFADI 318
D + ++A +G G++D +FD ++ L SH++ + +VAF+
Sbjct: 228 D-----INAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMY-SHDNIICGITSVAFSR- 280
Query: 319 SSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQT 378
S ++L +G DD C +WD M+ D G LAGH + ++ + D + + S D
Sbjct: 281 SGRLLLAGYDDFNCNIWD--AMKGDR---AGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 379 IKLWD 383
+K+W+
Sbjct: 336 LKIWN 340
Score = 56.2 bits (134), Expect = 7e-08
Identities = 63/252 (25%), Positives = 100/252 (39%), Gaps = 21/252 (8%)
Query: 268 VFSIAVSSDGREVLGGANDGCLYVFD---REQNRR-TLQIESHEDDVNAVAFADISSQIL 323
V + A + G V G D ++ RE N R + ++ H ++ F D +QI+
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLD-DNQII 158
Query: 324 FSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
S GD C +WD T ++ VG AGH + + D R +S + D +IKLWD
Sbjct: 159 TSSGDTT-CALWDIETGQQT----VG-FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWD 212
Query: 384 IRRFSSRE---GMEASRQAATQQNWDYRWQQVPKKA-WRKLKLPGDSSLMTYRGHGVLHT 439
+R R+ G E+ A Y + A R L D L+ Y H
Sbjct: 213 VRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-----HD 267
Query: 440 LIRCRFSPI-HSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKI 498
I C + + S + + +G ++D + G L H V + +
Sbjct: 268 NIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
Query: 499 VSSSWDGNLRLW 510
+ SWD L++W
Sbjct: 328 ATGSWDSFLKIW 339
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 57.8 bits (138), Expect = 3e-08
Identities = 56/260 (21%), Positives = 102/260 (39%), Gaps = 54/260 (20%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
AV+ +A G + G++D + ++ R + H +++ +A + + ++ +G
Sbjct: 188 AVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMA-VNYENTMIAAG 246
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFID----SKGDARYLISNSKDQTIKLW 382
D I +VW RT PV L GH IT + +KG RY++S D T+ W
Sbjct: 247 SCDKIIRVWCLRTCA-----PVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFW 301
Query: 383 DIRRFSSREGMEASRQAATQQNWD---YRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHT 439
WD ++ P K K + PG L +
Sbjct: 302 ---------------------QWDLESLKFSPRPLKFTEKPR-PGVQMLCS--------- 330
Query: 440 LIRCRFSPIHSTGQQFIYSGCSTGKVVVYDL--LSGHIVKKLTNHKACVRDVSWHPFEEK 497
S G F+ +G + + +Y L + + +L +H V + + ++
Sbjct: 331 --------SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDR 382
Query: 498 IVSSSWDGNLRLWQYRQAEY 517
+S S DG R+W++ Q E+
Sbjct: 383 FLSGSRDGTARIWRFEQLEW 402
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/190 (23%), Positives = 75/190 (39%), Gaps = 15/190 (7%)
Query: 160 FLPNDLGFTDSYSQ--KAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDV 217
F P L FT+ + C +S G + D IR+Y + K +++
Sbjct: 310 FSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTD 369
Query: 218 GWSVLDVAFTPDGNHFLYSS-------WS-DYIHICNIYGEGDTHTALDLRPDERRFA-- 267
V + F +G+ FL S W + + +I + T + DL +E RF
Sbjct: 370 --KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKP 427
Query: 268 -VFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
V IA + + V+ ND L V++ + + H D+V + S+I+ S
Sbjct: 428 KVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSA 487
Query: 327 GDDAICKVWD 336
G D +WD
Sbjct: 488 GHDGSIFIWD 497
Score = 34.3 bits (77), Expect = 0.30
Identities = 41/174 (23%), Positives = 73/174 (41%), Gaps = 25/174 (14%)
Query: 230 GNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCL 289
G FL + +D H+ +Y G + V SI ++G L G+ DG
Sbjct: 335 GGMFLATGSTD--HVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTA 392
Query: 290 YVFDREQ-----------NRRTLQIESHED-----DVNAVAFADISSQILFSGGDDAICK 333
++ EQ R + + S E+ V +A+ S I+ + +D + K
Sbjct: 393 RIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDS-IVVTAVNDHVLK 451
Query: 334 VWDRRTMREDDPKPVGALAGHQDGITFIDSKG-DARYLISNSKDQTIKLWDIRR 386
VW+ T + + L GH D + +++ D+R ++S D +I +WDI +
Sbjct: 452 VWNSYT-----GQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITK 500
Score = 29.6 bits (65), Expect = 7.4
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 3/53 (5%)
Query: 183 DGQIFMSACQDQTIRLYDCRYGRFRK--FKSIKARDVGWSVLDVAFTPDGNHF 233
D +I +SA D +I ++D G K F I+ + G +V D F+ DG HF
Sbjct: 480 DSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHG-AVFDCKFSQDGQHF 531
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 57.8 bits (138), Expect = 3e-08
Identities = 56/260 (21%), Positives = 102/260 (39%), Gaps = 54/260 (20%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
AV+ +A G + G++D + ++ R + H +++ +A + + ++ +G
Sbjct: 188 AVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMA-VNYENTMIAAG 246
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFID----SKGDARYLISNSKDQTIKLW 382
D I +VW RT PV L GH IT + +KG RY++S D T+ W
Sbjct: 247 SCDKIIRVWCLRTCA-----PVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFW 301
Query: 383 DIRRFSSREGMEASRQAATQQNWD---YRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHT 439
WD ++ P K K + PG L +
Sbjct: 302 ---------------------QWDLESLKFSPRPLKFTEKPR-PGVQMLCS--------- 330
Query: 440 LIRCRFSPIHSTGQQFIYSGCSTGKVVVYDL--LSGHIVKKLTNHKACVRDVSWHPFEEK 497
S G F+ +G + + +Y L + + +L +H V + + ++
Sbjct: 331 --------SFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDR 382
Query: 498 IVSSSWDGNLRLWQYRQAEY 517
+S S DG R+W++ Q E+
Sbjct: 383 FLSGSRDGTARIWRFEQLEW 402
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/190 (23%), Positives = 75/190 (39%), Gaps = 15/190 (7%)
Query: 160 FLPNDLGFTDSYSQ--KAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDV 217
F P L FT+ + C +S G + D IR+Y + K +++
Sbjct: 310 FSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTD 369
Query: 218 GWSVLDVAFTPDGNHFLYSS-------WS-DYIHICNIYGEGDTHTALDLRPDERRFA-- 267
V + F +G+ FL S W + + +I + T + DL +E RF
Sbjct: 370 --KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKP 427
Query: 268 -VFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
V IA + + V+ ND L V++ + + H D+V + S+I+ S
Sbjct: 428 KVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSA 487
Query: 327 GDDAICKVWD 336
G D +WD
Sbjct: 488 GHDGSIFIWD 497
Score = 34.3 bits (77), Expect = 0.30
Identities = 41/174 (23%), Positives = 73/174 (41%), Gaps = 25/174 (14%)
Query: 230 GNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCL 289
G FL + +D H+ +Y G + V SI ++G L G+ DG
Sbjct: 335 GGMFLATGSTD--HVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTA 392
Query: 290 YVFDREQ-----------NRRTLQIESHED-----DVNAVAFADISSQILFSGGDDAICK 333
++ EQ R + + S E+ V +A+ S I+ + +D + K
Sbjct: 393 RIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDS-IVVTAVNDHVLK 451
Query: 334 VWDRRTMREDDPKPVGALAGHQDGITFIDSKG-DARYLISNSKDQTIKLWDIRR 386
VW+ T + + L GH D + +++ D+R ++S D +I +WDI +
Sbjct: 452 VWNSYT-----GQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITK 500
Score = 29.6 bits (65), Expect = 7.4
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 3/53 (5%)
Query: 183 DGQIFMSACQDQTIRLYDCRYGRFRK--FKSIKARDVGWSVLDVAFTPDGNHF 233
D +I +SA D +I ++D G K F I+ + G +V D F+ DG HF
Sbjct: 480 DSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHG-AVFDCKFSQDGQHF 531
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 57.8 bits (138), Expect = 3e-08
Identities = 34/124 (27%), Positives = 66/124 (53%), Gaps = 7/124 (5%)
Query: 263 ERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTL-QIESHEDDVNAVAFADISSQ 321
ER + +++ ++ G++D L+++ ++++ L ++ H+ +N V F+ S+
Sbjct: 35 ERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSR 93
Query: 322 ILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 381
I+ S D K+WD RT K + +L GH + I D+R L+S S D T+K+
Sbjct: 94 IVASASFDKSIKLWDGRT-----GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKV 148
Query: 382 WDIR 385
WD++
Sbjct: 149 WDVK 152
Score = 49.7 bits (117), Expect = 7e-06
Identities = 45/189 (23%), Positives = 69/189 (36%), Gaps = 48/189 (25%)
Query: 323 LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
L SG DD +W +D KP+ + GHQ I + D+R + S S D++IKLW
Sbjct: 52 LVSGSDDFTLFLWSPA----EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 107
Query: 383 DIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIR 442
D R L + RGH +
Sbjct: 108 DGRT--------------------------------------GKYLASLRGH------VA 123
Query: 443 CRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSS 502
+ S + + SG S + V+D+ + + L H V V W P +++ S
Sbjct: 124 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 183
Query: 503 WDGNLRLWQ 511
D LR+W+
Sbjct: 184 KDKCLRIWR 192
Score = 47.4 bits (111), Expect = 3e-05
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)
Query: 271 IAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDA 330
+ S D R V + D + ++D + + H V +A++ S++L SG D+
Sbjct: 86 VLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS-ADSRLLVSGSSDS 144
Query: 331 ICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
KVWD + K L GH D + +D D + + S KD+ +++W
Sbjct: 145 TLKVWDVKAQ-----KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 45.8 bits (107), Expect = 1e-04
Identities = 24/71 (33%), Positives = 41/71 (57%), Gaps = 1/71 (1%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
AV+ IA S+D R ++ G++D L V+D + + + + H D+V AV ++ Q + SG
Sbjct: 124 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSP-DGQRVASG 182
Query: 327 GDDAICKVWDR 337
G D ++W R
Sbjct: 183 GKDKCLRIWRR 193
Score = 39.3 bits (90), Expect = 0.009
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 13/118 (11%)
Query: 179 IYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSW 238
++S D +I SA D++I+L+D R G++ S++ +V +A++ D + S
Sbjct: 87 LFSPDSRIVASASFDKSIKLWDGRTGKY--LASLRGHVA--AVYQIAWSADSRLLVSGSS 142
Query: 239 SDYIHICNIYGEGDTHTALDL--RPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDR 294
+ + ++ + A+DL DE V+++ S DG+ V G D CL ++ R
Sbjct: 143 DSTLKVWDVKAQ---KLAMDLPGHADE----VYAVDWSPDGQRVASGGKDKCLRIWRR 193
Score = 33.1 bits (74), Expect = 0.67
Identities = 18/76 (23%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 448 IHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNL 507
+ S + + S + ++D +G + L H A V ++W +VS S D L
Sbjct: 87 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTL 146
Query: 508 RLWQYRQAEYFQDDMP 523
++W + A+ D+P
Sbjct: 147 KVWDVK-AQKLAMDLP 161
Score = 32.7 bits (73), Expect = 0.88
Identities = 12/40 (30%), Positives = 24/40 (60%)
Query: 478 KLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEY 517
++T H+A + V + P + S+S+D +++LW R +Y
Sbjct: 75 RMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 114
>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
sapiens]
Length = 1802
Score = 57.8 bits (138), Expect = 3e-08
Identities = 63/263 (23%), Positives = 103/263 (39%), Gaps = 58/263 (22%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
+V+ +A GR + G++D + ++ + R + H +++ +A + + ++ +G
Sbjct: 182 SVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMA-VNYENTLIAAG 240
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFID----SKGDARYLISNSKDQTIKLW 382
D + +VW RT PV L GH IT I +KG RYL S D TI W
Sbjct: 241 SCDKVVRVWCLRTCA-----PVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW 295
Query: 383 DIRRFSSREGMEASRQAATQQNW---DYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHT 439
W +++ P K + + PG
Sbjct: 296 ---------------------QWHVKTMKFRDRPVKFTERSR-PG--------------V 319
Query: 440 LIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPF----- 494
I C S+G FI +G ST V+ L + +K+ ++ V F
Sbjct: 320 QISC---SSFSSGGMFITTG-STDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGD 375
Query: 495 EEKIVSSSWDGNLRLWQYRQAEY 517
+ VS S DG R+WQY+Q E+
Sbjct: 376 SLRFVSGSRDGTARIWQYQQQEW 398
Score = 32.0 bits (71), Expect = 1.5
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 183 DGQIFMSACQDQTIRLYDCRYG-RFRKFKSIKARDVGWSVLDVAFTPDGNHF 233
D +I +SA D I ++D G + R + ++ +V D F+PDGNHF
Sbjct: 477 DQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHF 528
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 57.4 bits (137), Expect = 3e-08
Identities = 72/307 (23%), Positives = 130/307 (42%), Gaps = 46/307 (14%)
Query: 221 VLDVAF---TPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDG 277
V+D+AF TP G +FL S+ D + +GDT + + AV+ ++ D
Sbjct: 17 VVDLAFSGITPYG-YFLISACKDGKPMLR---QGDTGDWIGTFLGHKG-AVWGATLNKDA 71
Query: 278 REVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDR 337
+ A D V+D + + +H+ V V F S+ +L +GG D + +++D
Sbjct: 72 TKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL-TGGQDKLLRIYDL 129
Query: 338 RTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASR 397
E +PK + +GH GI + + ++S + D+T++LWD + + + +
Sbjct: 130 NKP-EAEPKEI---SGHTSGIKKALWCSEDKQILS-ADDKTVRLWDHATMTEVKSLNFNM 184
Query: 398 QAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHS------- 450
++ + +P+ G+ ++TY H+ + PI S
Sbjct: 185 SVSSME-------YIPE---------GEILVITYGRSIAFHSAVS--LDPIKSFEAPATI 226
Query: 451 ------TGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWD 504
++F+ +G K+ YD SG ++ H + V + P E S S D
Sbjct: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
Query: 505 GNLRLWQ 511
G LRLWQ
Sbjct: 287 GTLRLWQ 293
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 57.4 bits (137), Expect = 3e-08
Identities = 67/324 (20%), Positives = 123/324 (37%), Gaps = 56/324 (17%)
Query: 207 RKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRF 266
R FK KA ++ + +P+G +SW ++ + N + + +
Sbjct: 12 RYFKGHKA-----AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVG-----HKD 61
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
V S+ S G + + D + ++ ++ + + ++H V +V F+ Q L +
Sbjct: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFS-ADGQFLATA 120
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD--- 383
+D KVW R + +L H + D R ++S S+D+TIK+WD
Sbjct: 121 SEDKSIKVWSMYRQRF-----LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 384 ---IRRFSSREG-------------MEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSS 427
+ FS G + ++ T + WD R ++
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL--------------- 220
Query: 428 LMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVR 487
L Y+ H + C H +G ++ + S G + + DLL G ++ L H V
Sbjct: 221 LQHYQVHS---GGVNC--ISFHPSG-NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
Query: 488 DVSWHPFEEKIVSSSWDGNLRLWQ 511
VS+ E S D + LW+
Sbjct: 275 TVSFSKGGELFASGGADTQVLLWR 298
Score = 57.4 bits (137), Expect = 3e-08
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 21/208 (10%)
Query: 180 YSKDGQIFMSACQDQTIRLY-DCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSW 238
+S G + SA +D+T+RL+ + G+F +FK+ A V V F+ DG +S
Sbjct: 68 FSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTA-----PVRSVDFSADGQFLATASE 122
Query: 239 SDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNR 298
I + ++Y + ++ L R A FS DGR ++ + D + ++D +
Sbjct: 123 DKSIKVWSMYRQRFLYS-LYRHTHWVRCAKFS----PDGRLIVSCSEDKTIKIWDTTNKQ 177
Query: 299 RTLQIESHEDDVNAVAFADI--SSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQD 356
+ + D V F D S + S G D KVWD R + V H
Sbjct: 178 C---VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV-----HSG 229
Query: 357 GITFIDSKGDARYLISNSKDQTIKLWDI 384
G+ I YLI+ S D T+K+ D+
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKILDL 257
Score = 38.5 bits (88), Expect = 0.016
Identities = 37/166 (22%), Positives = 72/166 (43%), Gaps = 24/166 (14%)
Query: 177 CGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYS 236
C +S DG++ +S +D+TI+++D ++ + + VG++ V F P G +
Sbjct: 149 CAKFSPDGRLIVSCSEDKTIKIWDTTN---KQCVNNFSDSVGFANF-VDFNPSGTCIASA 204
Query: 237 SWSDYIHICNIYGEGDTHTALDLRPDE--RRFAVFS-----IAVSSDGREVLGGANDGCL 289
G T D+R ++ + + V S I+ G ++ ++DG L
Sbjct: 205 ------------GSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Query: 290 YVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVW 335
+ D + R ++ H V V+F+ ++ SGG D +W
Sbjct: 253 KILDLLEGRLIYTLQGHTGPVFTVSFSK-GGELFASGGADTQVLLW 297
Score = 29.3 bits (64), Expect = 9.7
Identities = 10/32 (31%), Positives = 19/32 (59%)
Query: 482 HKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
HKA + + P +++ ++SWD L LW ++
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFK 48
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 57.0 bits (136), Expect = 4e-08
Identities = 48/246 (19%), Positives = 98/246 (39%), Gaps = 12/246 (4%)
Query: 268 VFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGG 327
V S A S DG+ +L G+ DGC+Y ++ + ++ H V F+ + S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP-DGHLFASAS 82
Query: 328 DDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRF 387
D ++WD K + L GHQ + + D+R L S D+ + LWD++
Sbjct: 83 CDCTVRLWDVAR-----AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 388 SSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIR---CR 444
+ R + ++ + +W D ++T V H +
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT---PAVSHQALEGHSAN 194
Query: 445 FSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWD 504
S + + + SG + ++ + ++ +L H V+ +++ P E + S+ +
Sbjct: 195 ISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS 254
Query: 505 GNLRLW 510
+++W
Sbjct: 255 RMVKVW 260
Score = 53.1 bits (126), Expect = 6e-07
Identities = 41/216 (18%), Positives = 80/216 (37%), Gaps = 50/216 (23%)
Query: 298 RRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDG 357
RR H +VN+ AF+ Q+L +G +D W+ R+ + + L GH
Sbjct: 12 RRVKFFGQHGGEVNSSAFSP-DGQMLLTGSEDGCVYGWETRS-----GQLLWRLGGHTGP 65
Query: 358 ITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAW 417
+ F D S S D T++LWD+ R ++ +++ ++ +Q+ W
Sbjct: 66 VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
Query: 418 RKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVK 477
K +V+++D+ SG +++
Sbjct: 126 DK--------------------------------------------RVMLWDVQSGQMLR 141
Query: 478 KLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
L H+ ++ + P + + SWD + +W R
Sbjct: 142 LLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
Score = 47.8 bits (112), Expect = 3e-05
Identities = 50/211 (23%), Positives = 89/211 (42%), Gaps = 20/211 (9%)
Query: 176 FCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLY 235
FC +S DG +F SA D T+RL+D R + + +K SV V+F+PD
Sbjct: 68 FCR-FSPDGHLFASASCDCTVRLWD--VARAKCLRVLKGHQ--RSVETVSFSPDSRQLAS 122
Query: 236 SSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDRE 295
W + + ++ G L D + + FS V+ + G+ D ++++D
Sbjct: 123 GGWDKRVMLWDVQ-SGQMLRLLVGHRDSIQSSDFSPTVNC----LATGSWDSTVHIWDLR 177
Query: 296 QNRRTLQ---IESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALA 352
+ +E H +++ + ++ +S +L SG D +W T + L
Sbjct: 178 MVTPAVSHQALEGHSANISCLCYS--ASGLLASGSWDKTIHIWKPTT-----SSLLIQLK 230
Query: 353 GHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
GH + I D +L S + +K+WD
Sbjct: 231 GHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 4/74 (5%)
Query: 443 CRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSS 502
CRFSP G F + C V ++D+ ++ L H+ V VS+ P ++ S
Sbjct: 69 CRFSP---DGHLFASASCDC-TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGG 124
Query: 503 WDGNLRLWQYRQAE 516
WD + LW + +
Sbjct: 125 WDKRVMLWDVQSGQ 138
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 56.6 bits (135), Expect = 6e-08
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 50/208 (24%)
Query: 303 IESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFID 362
+ H V++V F+ + + L S D + K+W D K ++GH+ GI+ +
Sbjct: 41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-----DGKFEKTISGHKLGISDVA 94
Query: 363 SKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKL 422
D+ L+S S D+T+K+WD+
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVS------------------------------------- 117
Query: 423 PGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNH 482
L T +GH + + C F+P I SG V ++D+ +G +K L H
Sbjct: 118 -SGKCLKTLKGHS--NYVFCCNFNP----QSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170
Query: 483 KACVRDVSWHPFEEKIVSSSWDGNLRLW 510
V V ++ IVSSS+DG R+W
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 49.7 bits (117), Expect = 7e-06
Identities = 52/260 (20%), Positives = 105/260 (40%), Gaps = 18/260 (6%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
AV S+ S +G + + D + ++ + I H+ ++ VA++ S +L S
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-DSNLLVSA 105
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRR 386
DD K+WD K + L GH + + + + ++S S D+++++WD++
Sbjct: 106 SDDKTLKIWD-----VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 387 FSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFS 446
+ + A + +++ + ++ L D++ L TLI
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-----SGQCLKTLIDDDNP 215
Query: 447 PI----HSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNH---KACVRDVSWHPFEEKIV 499
P+ S ++I + + ++D G +K T H K C+ + IV
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 500 SSSWDGNLRLWQYRQAEYFQ 519
S S D + +W + E Q
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQ 295
Score = 39.3 bits (90), Expect = 0.009
Identities = 31/157 (19%), Positives = 73/157 (46%), Gaps = 6/157 (3%)
Query: 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWS 239
+++DG + +S+ D R++D G+ K D V V F+P+G + L ++
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLD 235
Query: 240 DYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
+ + + + Y +G +E+ + +F+ + G+ ++ G+ D +Y+++ +
Sbjct: 236 NTLKLWD-YSKGKCLKTYTGHKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Query: 300 TLQIESHEDDVNAVAFADISSQILFSG-GDDAICKVW 335
+++ H D V + A + I + +D K+W
Sbjct: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 56.6 bits (135), Expect = 6e-08
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 50/208 (24%)
Query: 303 IESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFID 362
+ H V++V F+ + + L S D + K+W D K ++GH+ GI+ +
Sbjct: 41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-----DGKFEKTISGHKLGISDVA 94
Query: 363 SKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKL 422
D+ L+S S D+T+K+WD+
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVS------------------------------------- 117
Query: 423 PGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNH 482
L T +GH + + C F+P I SG V ++D+ +G +K L H
Sbjct: 118 -SGKCLKTLKGHS--NYVFCCNFNP----QSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170
Query: 483 KACVRDVSWHPFEEKIVSSSWDGNLRLW 510
V V ++ IVSSS+DG R+W
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 49.7 bits (117), Expect = 7e-06
Identities = 52/260 (20%), Positives = 105/260 (40%), Gaps = 18/260 (6%)
Query: 267 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSG 326
AV S+ S +G + + D + ++ + I H+ ++ VA++ S +L S
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-DSNLLVSA 105
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRR 386
DD K+WD K + L GH + + + + ++S S D+++++WD++
Sbjct: 106 SDDKTLKIWD-----VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 387 FSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFS 446
+ + A + +++ + ++ L D++ L TLI
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-----SGQCLKTLIDDDNP 215
Query: 447 PI----HSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNH---KACVRDVSWHPFEEKIV 499
P+ S ++I + + ++D G +K T H K C+ + IV
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 500 SSSWDGNLRLWQYRQAEYFQ 519
S S D + +W + E Q
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQ 295
Score = 39.3 bits (90), Expect = 0.009
Identities = 31/157 (19%), Positives = 73/157 (46%), Gaps = 6/157 (3%)
Query: 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWS 239
+++DG + +S+ D R++D G+ K D V V F+P+G + L ++
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLD 235
Query: 240 DYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
+ + + + Y +G +E+ + +F+ + G+ ++ G+ D +Y+++ +
Sbjct: 236 NTLKLWD-YSKGKCLKTYTGHKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Query: 300 TLQIESHEDDVNAVAFADISSQILFSG-GDDAICKVW 335
+++ H D V + A + I + +D K+W
Sbjct: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|55741849 WD repeat domain 22 [Homo sapiens]
Length = 942
Score = 56.2 bits (134), Expect = 7e-08
Identities = 64/273 (23%), Positives = 115/273 (42%), Gaps = 27/273 (9%)
Query: 263 ERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQI 322
E +F +A +S +V G ND + + D E + TL + +HED V ++ + ++ I
Sbjct: 99 EHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSE-TLDVFAHEDAVYGLSVSPVNDNI 157
Query: 323 LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382
S DD +WD R +P + + F + + R L + + + + LW
Sbjct: 158 FASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMF--NPVEPRLLATANSKEGVGLW 215
Query: 383 DIRRFSS---REGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGD--SSLMTY----RG 433
DIR+ S R G S Q+A ++ Q+ R + D S L + +G
Sbjct: 216 DIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQG 275
Query: 434 HGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLS-------GHIVK----KLTNH 482
+ T+ C F+ Q+I SG + ++ + + G +V L H
Sbjct: 276 YFNSCTMKSCCFA---GDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGH 332
Query: 483 KACVRDVSWHPFEEKIVSSSWDGNLRLWQ-YRQ 514
++ V V ++P I SS + +++W Y+Q
Sbjct: 333 RSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQ 365
Score = 35.4 bits (80), Expect = 0.14
Identities = 21/79 (26%), Positives = 31/79 (39%)
Query: 306 HEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKG 365
H VNA+ F++ Q L SGGDD +W KP+ H I +
Sbjct: 52 HFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNS 111
Query: 366 DARYLISNSKDQTIKLWDI 384
+ S D+ + L D+
Sbjct: 112 GNTKVFSGGNDEQVILHDV 130
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 56.2 bits (134), Expect = 7e-08
Identities = 72/342 (21%), Positives = 127/342 (37%), Gaps = 76/342 (22%)
Query: 231 NHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLY 290
N LY W + +I N+ + L +RP AV+ S DG+ + D L
Sbjct: 590 NGMLYLEWINKKNITNL-------SRLVVRPHTD--AVYHACFSEDGQRIASCGADKTLQ 640
Query: 291 VFDREQNRRTLQIESHEDDVNAVAFA------------------------------DISS 320
VF E + L+I++HED+V AF+ + S
Sbjct: 641 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 700
Query: 321 QI-------------LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDA 367
Q+ L +G D K+WD + + + GH + + D
Sbjct: 701 QVNCCHFTNSSHHLLLATGSSDCFLKLWDL-----NQKECRNTMFGHTNSVNHCRFSPDD 755
Query: 368 RYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPK-KAW----RKLKL 422
+ L S S D T+KLWD + R+ + + ++ + + K +W ++ +
Sbjct: 756 KLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 815
Query: 423 PGDSSLMTYRGH-----GVLH-----TLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLS 472
+ + + H G +H T+ C FSP + + C V +++ S
Sbjct: 816 AAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYC----VELWNTDS 871
Query: 473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQ 514
V H + V V + P ++SS D +RLW+ ++
Sbjct: 872 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 913
Score = 42.0 bits (97), Expect = 0.001
Identities = 80/376 (21%), Positives = 143/376 (38%), Gaps = 75/376 (19%)
Query: 164 DLGFTDSYSQKAFCG---------IYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKA 214
+L TDS S+ A C ++S DG F+++ DQTIRL++ + + K ++
Sbjct: 865 ELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVML 922
Query: 215 RDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVS 274
+ +DV F + L + + N G T +D + + V +S
Sbjct: 923 KQE----VDVVFQENEVMVLAVDHIRRLQLIN----GRTGQ-IDYLTEAQ---VSCCCLS 970
Query: 275 SDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKV 334
+ + G +G + + + NR H+ V + F + L S DDA +V
Sbjct: 971 PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT-ADEKTLISSSDDAEIQV 1029
Query: 335 WDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGME 394
W+ + + L GHQ+ + ++R L+S S D T+K+W+I +
Sbjct: 1030 WNWQLDK------CIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNK----- 1077
Query: 395 ASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQ 454
+ + ++G T++ C S H +
Sbjct: 1078 ------------------------------EKDFVCHQG-----TVLSCDIS--HDATKF 1100
Query: 455 FIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQ 514
S T K+ +DLL + +L H CVR ++ + + +G +R+W
Sbjct: 1101 SSTSADKTAKIWSFDLLLP--LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158
Query: 515 AEYFQDDMPESEECAS 530
E P SEE A+
Sbjct: 1159 GELLHLCAPLSEEGAA 1174
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 56.2 bits (134), Expect = 7e-08
Identities = 72/342 (21%), Positives = 127/342 (37%), Gaps = 76/342 (22%)
Query: 231 NHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLY 290
N LY W + +I N+ + L +RP AV+ S DG+ + D L
Sbjct: 579 NGMLYLEWINKKNITNL-------SRLVVRPHTD--AVYHACFSEDGQRIASCGADKTLQ 629
Query: 291 VFDREQNRRTLQIESHEDDVNAVAFA------------------------------DISS 320
VF E + L+I++HED+V AF+ + S
Sbjct: 630 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 689
Query: 321 QI-------------LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDA 367
Q+ L +G D K+WD + + + GH + + D
Sbjct: 690 QVNCCHFTNSSHHLLLATGSSDCFLKLWDL-----NQKECRNTMFGHTNSVNHCRFSPDD 744
Query: 368 RYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPK-KAW----RKLKL 422
+ L S S D T+KLWD + R+ + + ++ + + K +W ++ +
Sbjct: 745 KLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 804
Query: 423 PGDSSLMTYRGH-----GVLH-----TLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLS 472
+ + + H G +H T+ C FSP + + C V +++ S
Sbjct: 805 AAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYC----VELWNTDS 860
Query: 473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQ 514
V H + V V + P ++SS D +RLW+ ++
Sbjct: 861 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902
Score = 42.0 bits (97), Expect = 0.001
Identities = 80/376 (21%), Positives = 143/376 (38%), Gaps = 75/376 (19%)
Query: 164 DLGFTDSYSQKAFCG---------IYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKA 214
+L TDS S+ A C ++S DG F+++ DQTIRL++ + + K ++
Sbjct: 854 ELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVML 911
Query: 215 RDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVS 274
+ +DV F + L + + N G T +D + + V +S
Sbjct: 912 KQE----VDVVFQENEVMVLAVDHIRRLQLIN----GRTGQ-IDYLTEAQ---VSCCCLS 959
Query: 275 SDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKV 334
+ + G +G + + + NR H+ V + F + L S DDA +V
Sbjct: 960 PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT-ADEKTLISSSDDAEIQV 1018
Query: 335 WDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGME 394
W+ + + L GHQ+ + ++R L+S S D T+K+W+I +
Sbjct: 1019 WNWQLDK------CIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNK----- 1066
Query: 395 ASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQ 454
+ + ++G T++ C S H +
Sbjct: 1067 ------------------------------EKDFVCHQG-----TVLSCDIS--HDATKF 1089
Query: 455 FIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQ 514
S T K+ +DLL + +L H CVR ++ + + +G +R+W
Sbjct: 1090 SSTSADKTAKIWSFDLLLP--LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
Query: 515 AEYFQDDMPESEECAS 530
E P SEE A+
Sbjct: 1148 GELLHLCAPLSEEGAA 1163
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 55.8 bits (133), Expect = 1e-07
Identities = 46/191 (24%), Positives = 83/191 (43%), Gaps = 23/191 (12%)
Query: 328 DDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRF 387
DD + ++ D +T E + L GH + D YL+S+S+D T++LW ++ F
Sbjct: 521 DDVLERIMDEKTASE-----LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575
Query: 388 SSREGMEASRQAATQQNWD-----YRWQQVPKKAWRKLKLPGD---SSLMTYRGHGVLHT 439
+ G + WD Y + V R +L L + GH L
Sbjct: 576 TCLVGYKGHNYPV----WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGH--LAD 629
Query: 440 LIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIV 499
+ RF P ++ +G + V ++D+L+G+ V+ T HK + +++ P +
Sbjct: 630 VNCTRFHP----NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685
Query: 500 SSSWDGNLRLW 510
+ + DG + LW
Sbjct: 686 TGATDGRVLLW 696
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/243 (21%), Positives = 96/243 (39%), Gaps = 26/243 (10%)
Query: 155 RVISHFLPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKA 214
R++ ++L +S + +S D +S+ +D T+RL+ + F K
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ--TFTCLVGYKG 583
Query: 215 RDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVS 274
+ + V D F+P G +F+ + + ++ A D R FA V+
Sbjct: 584 HN--YPVWDTQFSPYGYYFVSGG---HDRVARLW-------ATDHYQPLRIFAGHLADVN 631
Query: 275 S-----DGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDD 329
+ V G+ D + ++D H+ ++++ F+ + + L +G D
Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATD 690
Query: 330 AICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD-IRRFS 388
+WD VG L GH D + + D L S S D T++LWD I+ F
Sbjct: 691 GRVLLWDI-----GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745
Query: 389 SRE 391
E
Sbjct: 746 DLE 748
Score = 32.7 bits (73), Expect = 0.88
Identities = 32/155 (20%), Positives = 60/155 (38%), Gaps = 15/155 (9%)
Query: 357 GITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQV-PKK 415
G+T +D D+ + D T+++W + R +AS + + D +++ +K
Sbjct: 472 GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEK 531
Query: 416 AWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHI 475
+LK+ +G + FSP + ++ S G V ++ L +
Sbjct: 532 TASELKIL----------YGHSGPVYGASFSP----DRNYLLSSSEDGTVRLWSLQTFTC 577
Query: 476 VKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
+ H V D + P+ VS D RLW
Sbjct: 578 LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW 612
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/252 (25%), Positives = 97/252 (38%), Gaps = 21/252 (8%)
Query: 268 VFSIAVSSDGREVLGGANDGCLYVFD---REQNRR-TLQIESHEDDVNAVAFADISSQIL 323
V + A + G V G D +++ RE N R + ++ H ++ F D SQI+
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLD-DSQIV 158
Query: 324 FSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
S GD C +WD T ++ GH + + D R +S + D + KLWD
Sbjct: 159 TSSGDTT-CALWDIETAQQTT-----TFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWD 212
Query: 384 IRRFSSRE---GMEASRQAATQQNWDYRWQQVPKKA-WRKLKLPGDSSLMTYRGHGVLHT 439
IR R+ G + A + Y + A R L D L+ Y H
Sbjct: 213 IRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-----HD 267
Query: 440 LIRCRFSPI-HSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKI 498
I C + + S + + +G V+D L G L H V + +
Sbjct: 268 NIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
Query: 499 VSSSWDGNLRLW 510
+ SWD LR+W
Sbjct: 328 ATGSWDSFLRIW 339
Score = 46.6 bits (109), Expect = 6e-05
Identities = 31/117 (26%), Positives = 61/117 (52%), Gaps = 10/117 (8%)
Query: 270 SIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHED---DVNAVAFADISSQILFSG 326
+++ +G G++D +FD ++ L + SH++ + +VAF+ S ++L +G
Sbjct: 231 AVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGITSVAFSK-SGRLLLAG 288
Query: 327 GDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
DD C VWD T++ D G LAGH + ++ + D + + S D +++W+
Sbjct: 289 YDDFNCNVWD--TLKGDR---AGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/156 (23%), Positives = 70/156 (44%), Gaps = 8/156 (5%)
Query: 181 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD 240
S D + F+S D + +L+D R G R+ + D+ V+F P+G + +++ SD
Sbjct: 193 SPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN----AVSFFPNG--YAFATGSD 246
Query: 241 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT 300
C ++ L D + S+A S GR +L G +D V+D + R
Sbjct: 247 DA-TCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRA 305
Query: 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWD 336
+ H++ V+ + D + +G D+ ++W+
Sbjct: 306 GVLAGHDNRVSCLGVTD-DGMAVATGSWDSFLRIWN 340
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,797,870
Number of Sequences: 37866
Number of extensions: 1072816
Number of successful extensions: 6555
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 4798
Number of HSP's gapped (non-prelim): 1414
length of query: 546
length of database: 18,247,518
effective HSP length: 107
effective length of query: 439
effective length of database: 14,195,856
effective search space: 6231980784
effective search space used: 6231980784
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.