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Search of human proteins with 31377705
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31377705 centrosomal protein 97kDa [Homo sapiens]
(865 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31377705 centrosomal protein 97kDa [Homo sapiens] 1718 0.0
gi|66472382 nischarin [Homo sapiens] 84 6e-16
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap... 83 1e-15
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 80 6e-15
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s... 70 6e-12
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s... 70 6e-12
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s... 70 6e-12
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s... 70 6e-12
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 70 6e-12
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 69 2e-11
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 69 2e-11
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 62 3e-09
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 61 4e-09
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 60 9e-09
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 60 9e-09
gi|61966709 leucine rich repeat containing 67 [Homo sapiens] 59 3e-08
gi|31621309 leucine rich repeat containing 6 [Homo sapiens] 58 3e-08
gi|157674358 leucine rich repeat containing 50 [Homo sapiens] 56 1e-07
gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo... 56 1e-07
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 55 2e-07
gi|157785649 leucine-rich repeats and IQ motif containing 3 [Hom... 55 3e-07
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 54 8e-07
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 54 8e-07
gi|226342935 podocan-like 1 isoform 3 [Homo sapiens] 53 1e-06
gi|239752518 PREDICTED: similar to leucine rich repeat containin... 52 2e-06
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 52 2e-06
gi|238908508 leucine-rich repeat and death domain-containing pro... 52 3e-06
gi|40217817 slit and trk like 1 protein [Homo sapiens] 52 3e-06
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 50 7e-06
gi|198041768 synleurin [Homo sapiens] 50 9e-06
>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
Length = 865
Score = 1718 bits (4449), Expect = 0.0
Identities = 865/865 (100%), Positives = 865/865 (100%)
Query: 1 MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRL 60
MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRL
Sbjct: 1 MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRL 60
Query: 61 IQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI 120
IQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI
Sbjct: 61 IQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI 120
Query: 121 NSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAEN 180
NSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAEN
Sbjct: 121 NSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAEN 180
Query: 181 EIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQ 240
EIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQ
Sbjct: 181 EIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQ 240
Query: 241 KESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFH 300
KESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFH
Sbjct: 241 KESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFH 300
Query: 301 QRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQ 360
QRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQ
Sbjct: 301 QRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQ 360
Query: 361 LFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVE 420
LFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVE
Sbjct: 361 LFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVE 420
Query: 421 LRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAG 480
LRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAG
Sbjct: 421 LRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAG 480
Query: 481 LLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMI 540
LLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMI
Sbjct: 481 LLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMI 540
Query: 541 LTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCL 600
LTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCL
Sbjct: 541 LTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCL 600
Query: 601 TDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTL 660
TDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTL
Sbjct: 601 TDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTL 660
Query: 661 VPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDF 720
VPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDF
Sbjct: 661 VPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDF 720
Query: 721 EKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQ 780
EKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQ
Sbjct: 721 EKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQ 780
Query: 781 QLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSK 840
QLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSK
Sbjct: 781 QLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSK 840
Query: 841 LNAEVQGQQPECDSTFQLLHVGVTV 865
LNAEVQGQQPECDSTFQLLHVGVTV
Sbjct: 841 LNAEVQGQQPECDSTFQLLHVGVTV 865
>gi|66472382 nischarin [Homo sapiens]
Length = 1504
Score = 84.0 bits (206), Expect = 6e-16
Identities = 86/284 (30%), Positives = 131/284 (46%), Gaps = 33/284 (11%)
Query: 82 LRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIG 140
L L+L HNSI + E +K + +E+L+L+ N L ++ + L HLDLS N +S +
Sbjct: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
Query: 141 DL-SKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQ 199
L +KL ++KTL L GN++ SL + + SL L L +N I + E+ + SL LE
Sbjct: 349 GLHTKLGNIKTLNLAGNLLESL--SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEH 406
Query: 200 LSIMNNPCVMATPSIPGFDYRPYIVSW--------CLNLRVLDGYVISQKESLKAEWLYS 251
+S++NNP + IP DYR +++ CL+ V + E LKA
Sbjct: 407 VSLLNNPLSI----IP--DYRTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAK 460
Query: 252 QGKGRAYRP---GQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQ--RFHQRQLMN 306
+ K + P G + + P +S + A + + ILS Q F Q + +
Sbjct: 461 EVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALA 520
Query: 307 QSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNS 350
S + + SL PEH Q C S ES P Q S
Sbjct: 521 SS----------LSSTDSLTPEHQPIAQGCSDSLESIPAGQAAS 554
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/212 (25%), Positives = 106/212 (50%), Gaps = 15/212 (7%)
Query: 10 LPPGEGSVVNWSGQGLQKLGPN---LPCEADIHTLILDKNQIIKL-ENLEKCKRLIQLSV 65
L P W +G GP +P + TL L N I ++ E+++ ++ L +
Sbjct: 258 LVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDL 317
Query: 66 ANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLK-ELVHLEWLNLAGNNLKAMEQINSCT 124
++N L+ + + L L L+L +N + +EGL +L +++ LNLAGN L+++ ++
Sbjct: 318 SHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLY 377
Query: 125 ALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEI-- 182
+L +LDL DN I Q+ ++ + SL L + L + P Y + LA +E+
Sbjct: 378 SLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCL 437
Query: 183 -------RDLNEISFLASLTELEQL-SIMNNP 206
++L+ + L ++ + +++ S ++NP
Sbjct: 438 DDTVTTEKELDTVEVLKAIQKAKEVKSKLSNP 469
>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
Length = 360
Score = 83.2 bits (204), Expect = 1e-15
Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 20/194 (10%)
Query: 23 QGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLL 82
Q L K NL + L L NQI K+ENLE L L ++ N L + GV KLT L
Sbjct: 107 QNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 166
Query: 83 RVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDL 142
+ L L +N I +E L L L+ L L N ++A+E I++ T L+ L L N I+++ +L
Sbjct: 167 KKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNL 226
Query: 143 SKLVSLKTLLLHGNIITSL-------RMAPAYLPRS-------------LAILSLAENEI 182
L +L L + N +T + + YL + L +L +A N I
Sbjct: 227 DALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRI 286
Query: 183 RDLNEISFLASLTE 196
+ + IS L L E
Sbjct: 287 KKIENISHLTELQE 300
Score = 80.1 bits (196), Expect = 8e-15
Identities = 48/129 (37%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
Query: 31 NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90
N+ ++ +L L KN+I KL+NL+ L LS+ +NRL ++ G+ L LR L L HN
Sbjct: 203 NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262
Query: 91 SIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLV---S 147
I +EGL+ L L++A N +K +E I+ T LQ ++DN + DL +L S
Sbjct: 263 GIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARS 322
Query: 148 LKTLLLHGN 156
L+T+ L N
Sbjct: 323 LETVYLERN 331
Score = 67.4 bits (163), Expect = 5e-11
Identities = 38/130 (29%), Positives = 71/130 (54%)
Query: 31 NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90
NL + L L N+I +EN++ L L + N++ ++ + LT L VL++ N
Sbjct: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240
Query: 91 SIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKT 150
+ +EGL+ LV+L L L+ N ++ +E + + L LD++ N I +I ++S L L+
Sbjct: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300
Query: 151 LLLHGNIITS 160
++ N++ S
Sbjct: 301 FWMNDNLLES 310
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/185 (29%), Positives = 87/185 (47%), Gaps = 18/185 (9%)
Query: 39 HTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGL 98
H L +D I NL++ + L+ + R+ ++ G L ++ L L N I C+E L
Sbjct: 63 HELPVDMETI----NLDRDAEDVDLN--HYRIGKIEGFEVLKKVKTLCLRQNLIKCIENL 116
Query: 99 KELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNII 158
+EL L L+L N +K +E + + T L+ LD+S N + I + KL LK L L N I
Sbjct: 117 EELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI 176
Query: 159 TSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASL----------TELEQLSIMNNPCV 208
+ + L +L L N IR + I L +L T+L+ L + N V
Sbjct: 177 SKIENLSNL--HQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTV 234
Query: 209 MATPS 213
++ S
Sbjct: 235 LSMQS 239
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 80.5 bits (197), Expect = 6e-15
Identities = 66/220 (30%), Positives = 109/220 (49%), Gaps = 8/220 (3%)
Query: 30 PNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPH 89
P + E + L N I +++N+ ++LI L + +N++ + G++ L LRVL L
Sbjct: 106 PIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGK 165
Query: 90 NSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLK 149
N I + L+ L L+ L+L GN + +E IN L+ L+L+ N +S + +L+ L SL
Sbjct: 166 NRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLT 225
Query: 150 TLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVM 209
L L N IT +R LP L L L+ N I + +S LA + L ++ NP
Sbjct: 226 ELNLRHNQITFVRDVD-NLP-CLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQ 283
Query: 210 ATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWL 249
+ Y+ ++ + LR LD I+++E A L
Sbjct: 284 ES------WYKHTVLQNMMQLRQLDMKRITEEERRMASVL 317
>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 70.5 bits (171), Expect = 6e-12
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 31/191 (16%)
Query: 44 DKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVH 103
+ Q+ K E + K ++ L + ++R+ + + LR L L +N I +EGL+ L H
Sbjct: 30 EAGQLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAH 88
Query: 104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRM 163
L WL+L+ NN++ +E +++ L+ L L +N IS+I L LV L+
Sbjct: 89 LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQ-------------- 134
Query: 164 APAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYI 223
+LSL N I ++ I +L L LS+ NP A DY+ +I
Sbjct: 135 ----------VLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAE------DYKMFI 178
Query: 224 VSWCLNLRVLD 234
++ +L LD
Sbjct: 179 CAYLPDLMYLD 189
Score = 63.9 bits (154), Expect = 6e-10
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 7/140 (5%)
Query: 37 DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96
D+ +L LD I++++NL + + L +L + NN + ++ G+ L L L+L N+I +E
Sbjct: 44 DVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIE 103
Query: 97 GLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDN---NISQIGDLSKLVSLKTLLL 153
GL LV+LE L+L N + ++ +++ LQ L L +N N+ I L + L+TL L
Sbjct: 104 GLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSL 163
Query: 154 HGNIITSLR----MAPAYLP 169
N I+ AYLP
Sbjct: 164 SRNPISEAEDYKMFICAYLP 183
>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 70.5 bits (171), Expect = 6e-12
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 31/191 (16%)
Query: 44 DKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVH 103
+ Q+ K E + K ++ L + ++R+ + + LR L L +N I +EGL+ L H
Sbjct: 30 EAGQLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAH 88
Query: 104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRM 163
L WL+L+ NN++ +E +++ L+ L L +N IS+I L LV L+
Sbjct: 89 LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQ-------------- 134
Query: 164 APAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYI 223
+LSL N I ++ I +L L LS+ NP A DY+ +I
Sbjct: 135 ----------VLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAE------DYKMFI 178
Query: 224 VSWCLNLRVLD 234
++ +L LD
Sbjct: 179 CAYLPDLMYLD 189
Score = 63.9 bits (154), Expect = 6e-10
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 7/140 (5%)
Query: 37 DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96
D+ +L LD I++++NL + + L +L + NN + ++ G+ L L L+L N+I +E
Sbjct: 44 DVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIE 103
Query: 97 GLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDN---NISQIGDLSKLVSLKTLLL 153
GL LV+LE L+L N + ++ +++ LQ L L +N N+ I L + L+TL L
Sbjct: 104 GLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSL 163
Query: 154 HGNIITSLR----MAPAYLP 169
N I+ AYLP
Sbjct: 164 SRNPISEAEDYKMFICAYLP 183
>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 70.5 bits (171), Expect = 6e-12
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 31/191 (16%)
Query: 44 DKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVH 103
+ Q+ K E + K ++ L + ++R+ + + LR L L +N I +EGL+ L H
Sbjct: 30 EAGQLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAH 88
Query: 104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRM 163
L WL+L+ NN++ +E +++ L+ L L +N IS+I L LV L+
Sbjct: 89 LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQ-------------- 134
Query: 164 APAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYI 223
+LSL N I ++ I +L L LS+ NP A DY+ +I
Sbjct: 135 ----------VLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAE------DYKMFI 178
Query: 224 VSWCLNLRVLD 234
++ +L LD
Sbjct: 179 CAYLPDLMYLD 189
Score = 63.9 bits (154), Expect = 6e-10
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 7/140 (5%)
Query: 37 DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96
D+ +L LD I++++NL + + L +L + NN + ++ G+ L L L+L N+I +E
Sbjct: 44 DVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIE 103
Query: 97 GLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDN---NISQIGDLSKLVSLKTLLL 153
GL LV+LE L+L N + ++ +++ LQ L L +N N+ I L + L+TL L
Sbjct: 104 GLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSL 163
Query: 154 HGNIITSLR----MAPAYLP 169
N I+ AYLP
Sbjct: 164 SRNPISEAEDYKMFICAYLP 183
>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 70.5 bits (171), Expect = 6e-12
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 31/191 (16%)
Query: 44 DKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVH 103
+ Q+ K E + K ++ L + ++R+ + + LR L L +N I +EGL+ L H
Sbjct: 30 EAGQLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAH 88
Query: 104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRM 163
L WL+L+ NN++ +E +++ L+ L L +N IS+I L LV L+
Sbjct: 89 LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQ-------------- 134
Query: 164 APAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYI 223
+LSL N I ++ I +L L LS+ NP A DY+ +I
Sbjct: 135 ----------VLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAE------DYKMFI 178
Query: 224 VSWCLNLRVLD 234
++ +L LD
Sbjct: 179 CAYLPDLMYLD 189
Score = 63.9 bits (154), Expect = 6e-10
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 7/140 (5%)
Query: 37 DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96
D+ +L LD I++++NL + + L +L + NN + ++ G+ L L L+L N+I +E
Sbjct: 44 DVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIE 103
Query: 97 GLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDN---NISQIGDLSKLVSLKTLLL 153
GL LV+LE L+L N + ++ +++ LQ L L +N N+ I L + L+TL L
Sbjct: 104 GLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSL 163
Query: 154 HGNIITSLR----MAPAYLP 169
N I+ AYLP
Sbjct: 164 SRNPISEAEDYKMFICAYLP 183
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 70.5 bits (171), Expect = 6e-12
Identities = 158/753 (20%), Positives = 299/753 (39%), Gaps = 107/753 (14%)
Query: 79 LTLLRVLNLPHNSIG-----CVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSD 133
L L++ LNL + G +E L++ V LE LNL+ N + +E+++ L+ L+LS
Sbjct: 97 LALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSY 156
Query: 134 NNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLAS 193
N IS+I + + +L+ L L GN I + + +SL +L+L N+I L +IS L
Sbjct: 157 NKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKP 216
Query: 194 LTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQG 253
L +L L ++ NP V ++P Y + + +L L+G ++ ++ +A +S
Sbjct: 217 LQDLISLILVENPVV----TLP--HYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLE 270
Query: 254 KGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQ------ 307
+ ++++ T L +D KL K L ++ Q+Q +
Sbjct: 271 EVERLERDLEKKMIETEELKSKQTRFLEEIKNQD-KLNKSLKEEAMLQKQSCEELKSDLN 329
Query: 308 SQNEELSPLVPVETRASLIP-EHSSPVQDCQISQESEPV-IQVNSWVGIN-SNDDQLFAV 364
++NE L TRA E + +I + EP+ + + I+ + D+ +
Sbjct: 330 TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
Query: 365 KNNFPASVHTTRY----SRNDLHLEDIQTDED------------KLNCSLLSSESTFMPV 408
K+ + ++ T S + ++ ++ DE L+ L E
Sbjct: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAA 449
Query: 409 ASGLSPLSPTVELRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMR 468
+ LS L +E Q I E+ +E+++ + K+ + V +R
Sbjct: 450 QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLR 509
Query: 469 SEI----------NTEVNEKAGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKP 518
E E+ K + + I S KD HS +S +++Q DI
Sbjct: 510 QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK 569
Query: 519 ENTQPENK--ETISQATSE-----KLPMILTQRSVALGQDKVALQK-LNDAATKLQACWR 570
+ Q E++ E +S+ E L LT+ +A + AL+K L + LQ
Sbjct: 570 QYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE---ALKKDLEGVISGLQE--- 623
Query: 571 GFYARNYNPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWN 630
Y QA + E R++++ L + + +ERD+ I E + L
Sbjct: 624 --YLGTIKGQATQAQNE--CRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAE 679
Query: 631 QVRSLQVWQQTVDQRLSSWHTDVPPISSTLVPSKHPLFTQSQESSCDQNADWFIASDVAP 690
+LQ Q V+ L D+ + L +++ + D A
Sbjct: 680 LESALQE-QHEVNASLQQTQGDLSAYEAEL---------EARLNLRDAEA---------- 719
Query: 691 QEKSLPEFPDSGFHSSLTEQVHSLQHSLDFEKSSTEG---SESSIMGNSIDTVRYGKESD 747
+ L E++ + E+S+ + E + N++ ++ +E +
Sbjct: 720 --------------NQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
Query: 748 LGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQ 780
+E+ E + + + + DN+LL+Q L Q
Sbjct: 766 -----QENSELHAKLKHLQDDNNLLKQQLKDFQ 793
Score = 70.1 bits (170), Expect = 8e-12
Identities = 56/161 (34%), Positives = 88/161 (54%), Gaps = 14/161 (8%)
Query: 51 LENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLA 110
+ENLEKC +L L+++ N + ++ + KL LR LNL +N I +EG++ + +L+ LNLA
Sbjct: 118 IENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLA 177
Query: 111 GNNLKAMEQI--NSCTALQHLDLSDNNISQIGDLSKLVSLK---TLLLHGNIITSLRMAP 165
GN ++ + +L+ L+L N IS + D+SKL L+ +L+L N + +L P
Sbjct: 178 GNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTL---P 234
Query: 166 AYLP------RSLAILSLAENEIRDLNEISFLASLTELEQL 200
YL RSL L +D E SL E+E+L
Sbjct: 235 HYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERL 275
Score = 32.0 bits (71), Expect = 2.5
Identities = 66/334 (19%), Positives = 128/334 (38%), Gaps = 59/334 (17%)
Query: 518 PENTQPENKETISQATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNY 577
P +TQ E+KE +K+ T+ S + + A Q++ A + + +
Sbjct: 434 PLDTQLEDKE-------KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKI 486
Query: 578 NPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQV 637
+ KD+ Y+ R+Q + +LR+E + ++ Q++ +++ LQ+
Sbjct: 487 SEAGKDLLYKQLSGRLQL--------VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQI 538
Query: 638 WQQTVDQRLSSWHTDVPPISSTLVPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPE 697
++D + KH ++Q+S +Q D + E L E
Sbjct: 539 AIDSLDSK----------------DPKHS-HMKAQKSGKEQQLD-IMNKQYQQLESRLDE 580
Query: 698 FPDSGFHSSLTEQVHSLQHSLDFEKSSTEG--SESSIMGNSIDTVRYGKESDLGDVSEEH 755
L+ + D E+ TEG + + + ++ V G + LG + +
Sbjct: 581 I--------LSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 632
Query: 756 GEWNKESSNNEQDNSLLEQYLTSVQQLEDADERTNFDTETRDSKLHIACFPVQLDTLSDG 815
+ E + L Q LT V+Q D E D E +L +L+
Sbjct: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL------AELE----- 681
Query: 816 ASVDESHGISPPLQGEISQTQ-ENSKLNAEVQGQ 848
+++ E H ++ LQ QTQ + S AE++ +
Sbjct: 682 SALQEQHEVNASLQ----QTQGDLSAYEAELEAR 711
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 11/197 (5%)
Query: 54 LEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNN 113
LE K L QL + +N+L+ G+ + L+ HN + VEG++ L+ L L GN
Sbjct: 965 LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNY 1024
Query: 114 LKAMEQINSCTALQHLDLSDNNISQIGDLSK--LVSLKTLLLHGNIITSLRMAPAYLPRS 171
L + + + L+ L L DN+IS + S L L+ + + N +T ++ P + S
Sbjct: 1025 LSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLT--KIVPLFHFVS 1082
Query: 172 LAILSLAENEIRDL-NEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNL 230
L L ++ N + DL + I + + L +LS+ NP + T ++R ++ L
Sbjct: 1083 LEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQET------NWRDSLLKVLPAL 1136
Query: 231 RVLDGYVISQKESLKAE 247
R+L+G +++ + E
Sbjct: 1137 RILNGNILNSNSESRTE 1153
Score = 39.3 bits (90), Expect = 0.016
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 4/100 (4%)
Query: 93 GCV-EGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTL 151
GCV L E +L++L+L L ++ +++C L+++D +N+I I + L +L +
Sbjct: 808 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAI-ECENLENLCVV 866
Query: 152 LLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFL 191
LL+ N +TSL ++ L L+ N+I + FL
Sbjct: 867 LLNKNQLTSLHGLDGC--TNIQCLELSYNKITRIGYSFFL 904
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 11/197 (5%)
Query: 54 LEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNN 113
LE K L QL + +N+L+ G+ + L+ HN + VEG++ L+ L L GN
Sbjct: 965 LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNY 1024
Query: 114 LKAMEQINSCTALQHLDLSDNNISQIGDLSK--LVSLKTLLLHGNIITSLRMAPAYLPRS 171
L + + + L+ L L DN+IS + S L L+ + + N +T ++ P + S
Sbjct: 1025 LSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLT--KIVPLFHFVS 1082
Query: 172 LAILSLAENEIRDL-NEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNL 230
L L ++ N + DL + I + + L +LS+ NP + T ++R ++ L
Sbjct: 1083 LEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQET------NWRDSLLKVLPAL 1136
Query: 231 RVLDGYVISQKESLKAE 247
R+L+G +++ + E
Sbjct: 1137 RILNGNILNSNSESRTE 1153
Score = 39.3 bits (90), Expect = 0.016
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 4/100 (4%)
Query: 93 GCV-EGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTL 151
GCV L E +L++L+L L ++ +++C L+++D +N+I I + L +L +
Sbjct: 808 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAI-ECENLENLCVV 866
Query: 152 LLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFL 191
LL+ N +TSL ++ L L+ N+I + FL
Sbjct: 867 LLNKNQLTSLHGLDGC--TNIQCLELSYNKITRIGYSFFL 904
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 61.6 bits (148), Expect = 3e-09
Identities = 58/229 (25%), Positives = 98/229 (42%), Gaps = 27/229 (11%)
Query: 38 IHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEG 97
+ L L N+I L + L++L+ + N L L+ + HN I +
Sbjct: 151 LQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICD 210
Query: 98 LKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGN- 156
L L L L GN ++ + + C L HL L++N I+ I L+KL +K L L N
Sbjct: 211 LSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQ 269
Query: 157 --IITSLRMAPAYLPRSLA-----------------ILSLAENEIRDLNEISFLASLTEL 197
+IT L A L+ +++L +N+I +L EI ++ +L L
Sbjct: 270 IEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPIL 329
Query: 198 EQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKA 246
L+++ NP + +Y +++ L L LD I +E + A
Sbjct: 330 RVLNLLENPIQEKS------EYWFFVIFMLLRLTELDQKKIKVEEKVSA 372
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/151 (28%), Positives = 72/151 (47%), Gaps = 6/151 (3%)
Query: 61 IQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI 120
+ L+++ L+ + + L+ L+L N I + + + +L LN + NNL
Sbjct: 130 LNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNF 189
Query: 121 NSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAEN 180
L+ D S N IS+I DLS +L L+L GN I + + + +L LSLA N
Sbjct: 190 KPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEI--SGLEMCNNLIHLSLANN 247
Query: 181 EIRDLNEISFLASLTELEQLSIMNNPCVMAT 211
+I +N ++ L ++ L + NN M T
Sbjct: 248 KITTINGLNKL----PIKILCLSNNQIEMIT 274
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 61.2 bits (147), Expect = 4e-09
Identities = 52/182 (28%), Positives = 98/182 (53%), Gaps = 6/182 (3%)
Query: 21 SGQGLQKLGPNLPCEADIHTLILDKNQIIKLEN-LEKCKRLIQLSVANNRL-VRMMGVAK 78
S LQ L +L + L + NQ+ L + + + + L +L+V++N+L + +
Sbjct: 90 SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149
Query: 79 LTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAM-EQINSCTALQHLDLSDNNI 136
L L+ L L HN + C+ EG ++L +LE L+L+ N+L + +S ++L L+LS N +
Sbjct: 150 LRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNEL 209
Query: 137 SQI-GDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLT 195
+ +++++ LK L + N++ ++ A + SL +L L N++R L E + L
Sbjct: 210 KSLPAEINRMKRLKHLDCNSNLLETIPPELAGM-ESLELLYLRRNKLRFLPEFPSCSLLK 268
Query: 196 EL 197
EL
Sbjct: 269 EL 270
Score = 41.6 bits (96), Expect = 0.003
Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 21/139 (15%)
Query: 25 LQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRV 84
L+ + P L + L L +N++ L C L +L V N++ +
Sbjct: 232 LETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEA--------- 282
Query: 85 LNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAM-EQINSCTALQHLDLSDNNISQIGDLS 143
E LK L + L+L N LK++ ++I +L+ LDLS+N+IS +
Sbjct: 283 -----------EHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSL 331
Query: 144 KLVSLKTLLLHGNIITSLR 162
+ LK L L GN + ++R
Sbjct: 332 GNLHLKFLALEGNPLRTIR 350
Score = 35.8 bits (81), Expect = 0.18
Identities = 34/111 (30%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 53 NLEKC--KRLIQLSVANNRLVRMMG-VAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLN 108
+LE C ++L L + NN L + + L L+ +NL N + E L + LE +
Sbjct: 465 SLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETIL 524
Query: 109 LAGNNLKAME--QINSCTALQHLDLSDNNISQIG-DLSKLVSLKTLLLHGN 156
++ N + +++ ++ L LDL +N++ QI +L V+L+TLLL GN
Sbjct: 525 ISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 30.8 bits (68), Expect = 5.7
Identities = 24/93 (25%), Positives = 48/93 (51%), Gaps = 3/93 (3%)
Query: 30 PNLPCEADIHTLILDKNQI--IKLENLEKCKRLIQLSVANNRLVRMMG-VAKLTLLRVLN 86
P P + + L + +NQI ++ E+L+ ++ L + +N+L + + L L L+
Sbjct: 259 PEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
Query: 87 LPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQ 119
L +N I + +HL++L L GN L+ + +
Sbjct: 319 LSNNDISSLPYSLGNLHLKFLALEGNPLRTIRR 351
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 60.1 bits (144), Expect = 9e-09
Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 5/124 (4%)
Query: 23 QGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLL 82
+GLQ + L ++ +H + L N I K+E ++ L L +++N++ R+ G+ LT L
Sbjct: 31 KGLQSIS-ELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKL 89
Query: 83 RVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQH----LDLSDNNISQ 138
LNL N I VEGL+EL++L LN++ N++ + + ++H +DL N I
Sbjct: 90 CTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDS 149
Query: 139 IGDL 142
I L
Sbjct: 150 IHHL 153
Score = 51.6 bits (122), Expect = 3e-06
Identities = 45/168 (26%), Positives = 84/168 (50%), Gaps = 8/168 (4%)
Query: 73 MMGVAKLTL---LRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHL 129
+ +++L+L L +NL N+I +E + + +L+ L+L+ N + +E +N+ T L L
Sbjct: 33 LQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTL 92
Query: 130 DLSDNNISQIGDLSKLVSLKTLLLHGNIITSLR-MAPAY-LPRSLAILSLAENEIRDLNE 187
+LS N I+++ L +L++L L + N I L + P + + L + L N I ++
Sbjct: 93 NLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHH 152
Query: 188 -ISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLD 234
+ + L L L + + +PG YR I+ LR+LD
Sbjct: 153 LLQCMVGLHFLTNLILEKDGDDNPVCRLPG--YRAVILQTLPQLRILD 198
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 60.1 bits (144), Expect = 9e-09
Identities = 58/200 (29%), Positives = 92/200 (46%), Gaps = 37/200 (18%)
Query: 21 SGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEK-------CKRLIQLSVANNRLVRM 73
SG L LGP L + TL+ N++ L K C+ L L+++ N +
Sbjct: 76 SGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEV 135
Query: 74 -MGVAKLTLLRVLNLPHNSIGCVEG-LKELVHLEWLNLAGNNLKAM-EQINSCTALQHLD 130
+ +L L+ L+L N + + ++ L LE L L GN +K + ++ + +L +L
Sbjct: 136 PASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLV 195
Query: 131 LSDNNISQI-GDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEIS 189
L DN I I LS+L SL++L LH N++T YLPR
Sbjct: 196 LCDNKIQSIPPQLSQLHSLRSLSLHNNLLT-------YLPRE------------------ 230
Query: 190 FLASLTELEQLSIMNNPCVM 209
+ +L LE+LS+ NP V+
Sbjct: 231 -ILNLIHLEELSLRGNPLVV 249
>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
Length = 228
Score = 58.5 bits (140), Expect = 3e-08
Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 17/159 (10%)
Query: 39 HTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGL 98
H DKN I +E+L CK L L + +N + ++ + T L L L +N I C+E L
Sbjct: 32 HINFSDKN-IDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENL 90
Query: 99 KELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNII 158
+ L LE L L GN + +E + L+ L + + + L + + LH
Sbjct: 91 RSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRL----PLGEKLLFDPRTLHS--- 143
Query: 159 TSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTEL 197
L +SL IL+++ N I D+ ++ L +L +L
Sbjct: 144 ---------LAKSLCILNISNNNIDDITDLELLENLNQL 173
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/147 (27%), Positives = 67/147 (45%), Gaps = 9/147 (6%)
Query: 18 VNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVA 77
+N+S + + + C+ ++ L L N I ++ NL L L + NN + + +
Sbjct: 33 INFSDKNIDAIEDLSLCK-NLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLR 91
Query: 78 KLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI--------NSCTALQHL 129
L L L L N I +EGL+ L L L++ L E++ + +L L
Sbjct: 92 SLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCIL 151
Query: 130 DLSDNNISQIGDLSKLVSLKTLLLHGN 156
++S+NNI I DL L +L L+ N
Sbjct: 152 NISNNNIDDITDLELLENLNQLIAVDN 178
Score = 40.8 bits (94), Expect = 0.005
Identities = 41/156 (26%), Positives = 70/156 (44%), Gaps = 15/156 (9%)
Query: 31 NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90
NL ++ L L N I +ENL K+L +L + N + + G+ L LR L++ +
Sbjct: 67 NLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQ 126
Query: 91 SIGCVEGL---KELVH-----LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGD- 141
+ E L +H L LN++ NN+ + + L L DN + + D
Sbjct: 127 RLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDL 186
Query: 142 ---LSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAI 174
L+KL+ L + L+GN + + P Y R + +
Sbjct: 187 EFLLNKLMKLWKIDLNGNPVC---LKPKYRDRLILV 219
Score = 33.9 bits (76), Expect = 0.67
Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 8/97 (8%)
Query: 112 NNLKAM--EQINSCTA-LQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYL 168
+NLK E I+ C + H++ SD NI I DLS +L L L+ N I+ ++
Sbjct: 13 SNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCIS--QITNLNY 70
Query: 169 PRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNN 205
+L L L N I + I L SL +LE+L + N
Sbjct: 71 ATNLTHLYLQNNCI---SCIENLRSLKKLEKLYLGGN 104
>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
Length = 466
Score = 58.2 bits (139), Expect = 3e-08
Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 5/144 (3%)
Query: 60 LIQLSVANNRLVRMMGVAKLTL-LRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAME 118
L +LS+ + R+ + K L++L L +N IG +E + +L LE+LNLA NN++ +E
Sbjct: 23 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIE 82
Query: 119 QINSCTALQHLDLSDNNISQIGDLSKL---VSLKTLLLHGNIITSLRMAPAYLPRSLAIL 175
+ C L LDL+ N I ++ + L + LK L L GN S ++ +L L
Sbjct: 83 NLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
Query: 176 S-LAENEIRDLNEISFLASLTELE 198
L EI I L + +E
Sbjct: 143 KWLDGKEIEPSERIKALQDYSVIE 166
Score = 57.0 bits (136), Expect = 7e-08
Identities = 56/168 (33%), Positives = 79/168 (47%), Gaps = 18/168 (10%)
Query: 86 NLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINS-CTALQHLDLSDNNISQIGDLSK 144
N HN CV + LE L+L ++ +E I+ C L+ L L +N I +I ++SK
Sbjct: 12 NAEHND--CV-----IFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSK 64
Query: 145 LVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMN 204
L L+ L L N I + LA L L N I +L+ I L L++L +M
Sbjct: 65 LKKLEYLNLALNNIEKIENLEGC--EELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMG 122
Query: 205 NPCVMATPSIPGFD-YRPYIVSWCLNLRVLDGYVISQKESLKAEWLYS 251
NPC FD YR ++V+ L+ LDG I E +KA YS
Sbjct: 123 NPCA-------SFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYS 163
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Query: 37 DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96
D+ L L N I K+EN+ K K+L L++A N + ++ + L L+L N IG +
Sbjct: 45 DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELS 104
Query: 97 GLKEL---VHLEWLNLAGN 112
+K L +HL+ L L GN
Sbjct: 105 SIKNLQHNIHLKELFLMGN 123
>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
Length = 725
Score = 56.2 bits (134), Expect = 1e-07
Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 8/143 (5%)
Query: 31 NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90
NL + L L N I K+ENLE L L + N L ++ + L L LNL +N
Sbjct: 124 NLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNN 183
Query: 91 SIGCVEGLKELVHLEWLNLAGNNLKAMEQI---NSCTALQHLDLSDNNISQ---IGDLSK 144
I +E L L L L +A N+L+ +E I C L LDLS N +S + L
Sbjct: 184 YIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 243
Query: 145 LVSLKTLLLHGNIITSLRMAPAY 167
+ L+ L L GN + +R P Y
Sbjct: 244 MPDLRVLNLMGNPV--IRQIPNY 264
>gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo
sapiens]
Length = 255
Score = 56.2 bits (134), Expect = 1e-07
Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 107 LNLAGNNLKAMEQINSCT-ALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAP 165
L+L G + +E + + +D SDN I ++ L LKTLL++ N I +
Sbjct: 24 LDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGL 83
Query: 166 AYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVS 225
L L L N + +L ++ LASL L LSI+ NP YR Y++
Sbjct: 84 DQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKK------HYRLYVIY 137
Query: 226 WCLNLRVLDGYVISQKESLKAEWLYSQGKG 255
+RVLD + KE +AE ++ +G
Sbjct: 138 KVPQVRVLDFQKVKLKERQEAEKMFKGKRG 167
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 55.5 bits (132), Expect = 2e-07
Identities = 46/152 (30%), Positives = 78/152 (51%), Gaps = 12/152 (7%)
Query: 62 QLSVANNRL--VRMMGVAKLTLLRVLNLPHNSIGCVEGLKEL-VHLEWLNLAGNNLKAM- 117
+L +++NRL ++ ++ L LR + L +N + + L + ++ L+LAGN + +
Sbjct: 78 RLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEIL 137
Query: 118 -EQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAY---LPRSLA 173
E + +L+ LDLS NNIS++ + LK L L+ N +TS M P Y L +L
Sbjct: 138 PEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTS--MEPGYFDNLANTLL 195
Query: 174 ILSLAENEIRDLNEISFLASLTELEQLSIMNN 205
+L L N I + F L +L+ L + N
Sbjct: 196 VLKLNRNRISAIPPKMF--KLPQLQHLELNRN 225
Score = 38.5 bits (88), Expect = 0.027
Identities = 48/179 (26%), Positives = 85/179 (47%), Gaps = 16/179 (8%)
Query: 41 LILDKNQIIKLENL--EKCKRLIQLSVANNRLVRMMGVA--KLTLLRVLNLPHNSIGCVE 96
L L++N+I ++ L + L L + N + ++M A L+ + +L L HN++ +
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 97 G--LKELVHLEWLNLAGNNLKAM--EQINSCTALQHLDLSDNNISQIGDLS--KLVSLKT 150
L L+ L+ L+L+ N + + + C L LDL+ N++S++ D S L L T
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
Query: 151 LLLHGNIITSLRMAPAYLPRSLAILSLAENE----IRDLNEISFLASLTELEQLSIMNN 205
L + N ++ + SL L L NE I D+N + L +L +L + N
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN--GAFSGLDKLRRLILQGN 396
Score = 33.9 bits (76), Expect = 0.67
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 15/89 (16%)
Query: 63 LSVANNRLVRMMGVA--KLTLLRVLNLPHNSI--------GCVEGLKELVHLEWLNLAGN 112
L + NNR+ + A L+ L+ L+L +N I G GL +L L L GN
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLI---LQGN 396
Query: 113 NLKAMEQ--INSCTALQHLDLSDNNISQI 139
++++ + AL+HLDLSDN I +
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSL 425
>gi|157785649 leucine-rich repeats and IQ motif containing 3 [Homo
sapiens]
Length = 624
Score = 55.1 bits (131), Expect = 3e-07
Identities = 46/151 (30%), Positives = 76/151 (50%), Gaps = 10/151 (6%)
Query: 96 EGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHG 155
EG K+ V +++ L +LK+ME + SC +L+ S+N I+ I L + L L LHG
Sbjct: 25 EGQKDFVFVKFNGL---HLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHG 81
Query: 156 NIITSLRMAPAYLP-RSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSI 214
N I SL + ++L +L L +N L I L++ L L++ + P +
Sbjct: 82 NQIKSLPNTKFWNGLKNLKLLYLHDNGFAKLKNICVLSACPTLIALTMFDCPVSLKK--- 138
Query: 215 PGFDYRPYIVSWCLNLRVLDGYVISQKESLK 245
YR +V+ L+ LD +VIS +E ++
Sbjct: 139 ---GYRHVLVNSIWPLKALDHHVISDEEIIQ 166
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 53.5 bits (127), Expect = 8e-07
Identities = 45/149 (30%), Positives = 76/149 (51%), Gaps = 12/149 (8%)
Query: 65 VANNRL--VRMMGVAKLTLLRVLNLPHNSIGCVEGLKEL-VHLEWLNLAGNNLKAM--EQ 119
+++NRL ++ ++ L LR + L +N + + L + ++ L+LAGN + + E
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80
Query: 120 INSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAY---LPRSLAILS 176
+ +L+ LDLS NNIS++ + LK L L+ N +TS M P Y L +L +L
Sbjct: 81 LKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTS--MEPGYFDNLANTLLVLK 138
Query: 177 LAENEIRDLNEISFLASLTELEQLSIMNN 205
L N I + F L +L+ L + N
Sbjct: 139 LNRNRISAIPPKMF--KLPQLQHLELNRN 165
Score = 38.5 bits (88), Expect = 0.027
Identities = 48/179 (26%), Positives = 85/179 (47%), Gaps = 16/179 (8%)
Query: 41 LILDKNQIIKLENL--EKCKRLIQLSVANNRLVRMMGVA--KLTLLRVLNLPHNSIGCVE 96
L L++N+I ++ L + L L + N + ++M A L+ + +L L HN++ +
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 97 G--LKELVHLEWLNLAGNNLKAM--EQINSCTALQHLDLSDNNISQIGDLS--KLVSLKT 150
L L+ L+ L+L+ N + + + C L LDL+ N++S++ D S L L T
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279
Query: 151 LLLHGNIITSLRMAPAYLPRSLAILSLAENE----IRDLNEISFLASLTELEQLSIMNN 205
L + N ++ + SL L L NE I D+N + L +L +L + N
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN--GAFSGLDKLRRLILQGN 336
Score = 33.9 bits (76), Expect = 0.67
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 15/89 (16%)
Query: 63 LSVANNRLVRMMGVA--KLTLLRVLNLPHNSI--------GCVEGLKELVHLEWLNLAGN 112
L + NNR+ + A L+ L+ L+L +N I G GL +L L L GN
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLI---LQGN 336
Query: 113 NLKAMEQ--INSCTALQHLDLSDNNISQI 139
++++ + AL+HLDLSDN I +
Sbjct: 337 RIRSITKKAFTGLDALEHLDLSDNAIMSL 365
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 53.5 bits (127), Expect = 8e-07
Identities = 55/181 (30%), Positives = 92/181 (50%), Gaps = 14/181 (7%)
Query: 34 CEADIHTLILDKNQIIKLEN--LEKCKRLIQLSVANN--RLVRMMGVAKLTLLRVLNLPH 89
C A + L L+ N I L L +L L++A N +L + G ++ + + LN+ H
Sbjct: 306 CSA-LEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEH 364
Query: 90 NSIGCVEG--LKELVHLEWLNLAGNNLKAME-QINSCTALQHLDLSDNNISQIG-DLSKL 145
N I + L LN+ N L ++ + T++ L+L+ N +++I D+S L
Sbjct: 365 NRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGL 424
Query: 146 VSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDL-NEISFLASLTELEQLSIMN 204
VSL+ L+L N++ L L R L L L EN++ L NEI++ L +L++L + N
Sbjct: 425 VSLEVLILSNNLLKKLPHGLGNL-RKLRELDLEENKLESLPNEIAY---LKDLQKLVLTN 480
Query: 205 N 205
N
Sbjct: 481 N 481
Score = 47.0 bits (110), Expect = 8e-05
Identities = 49/157 (31%), Positives = 78/157 (49%), Gaps = 11/157 (7%)
Query: 41 LILDKNQIIKL--ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSI-GCVE 96
L + +N+I +L E E C LI L VA+N+L + + T + L+L HN + +
Sbjct: 220 LSIRENKIKQLPAEIGELCN-LITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
Query: 97 GLKELVHLEWLNLAGNNLKAMEQ-INSCTALQHLDLSDNNISQIGD--LSKLVSLKTLLL 153
+ L L L L N L A+ + + C+AL+ L+L +NNIS + + LS LV L +L L
Sbjct: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTL 338
Query: 154 HGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISF 190
N ++ P P + + E +N+I F
Sbjct: 339 ARN---CFQLYPVGGPSQFSTIYSLNMEHNRINKIPF 372
>gi|226342935 podocan-like 1 isoform 3 [Homo sapiens]
Length = 421
Score = 52.8 bits (125), Expect = 1e-06
Identities = 57/175 (32%), Positives = 88/175 (50%), Gaps = 23/175 (13%)
Query: 63 LSVANNRLVRMM--GVAKLTLLRVLNLPHNSIGCVEGLKE-----LVHLEWLNLAGNNLK 115
LS+ NN+L + +++L+ LR LNL HN++ EGL + L L+ L +A N
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNL-HNNLISSEGLPDEAFESLTQLQHLCVAHNKNN 135
Query: 116 AMEQI-----NSCTALQHLDLSDNNISQIG----DLSKLVSLKTLLLHGNIITSLRMAPA 166
+ ++ + T L+ L L N ++ G SKL SL+ L L N +T++ PA
Sbjct: 136 LISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV---PA 192
Query: 167 YLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRP 221
LPR+LAIL L N IR + E + L L L + +N + + +P RP
Sbjct: 193 GLPRTLAILHLGRNRIRQV-EAARLHGARGLRYLLLQHNQ--LGSSGLPAGALRP 244
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/109 (33%), Positives = 52/109 (47%), Gaps = 9/109 (8%)
Query: 82 LRVLNLPHNSIGCVEGLKELVH---LEWLNLAGNNLKAME----QINSCTALQHLDLSDN 134
LR L LPHN + + G ++LV L LNLA N L + AL+ LDL+ N
Sbjct: 269 LRALVLPHNHVAAL-GARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGN 327
Query: 135 NISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIR 183
++++ + L+TL L N + L P L LSLA N +R
Sbjct: 328 QLTRL-PMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 375
>gi|239752518 PREDICTED: similar to leucine rich repeat containing
50, partial [Homo sapiens]
Length = 489
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 3/99 (3%)
Query: 63 LSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINS 122
L + N++ ++ + L LRVLNL N + V+ L L L LNL N + + +++
Sbjct: 8 LDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDN 67
Query: 123 CTALQHLDLSDNNISQIGDLSKLV---SLKTLLLHGNII 158
LQHL LS NNIS +S L SL + GN I
Sbjct: 68 LPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPI 106
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 54/198 (27%), Positives = 96/198 (48%), Gaps = 15/198 (7%)
Query: 16 SVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIK---------LENLEKCKRLIQLSVA 66
S V+ S L+ L NL D+ L L +N + + L L++ +L L+++
Sbjct: 128 SSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLS 187
Query: 67 NNRLVRM-MGVAKLTLLRVLNLPHNSIGCVEGLKELVH-LEWLNLAGNNLKAME-QINSC 123
NN L + V + L LN+ N++ V ++H L+ L GN L+++ ++ +
Sbjct: 188 NNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENM 247
Query: 124 TALQHLDLSDNNISQIGD-LSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEI 182
L +L LS N + I + L KL ++ L + GN + +LR+ + + L N I
Sbjct: 248 KQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVI 307
Query: 183 RDL--NEISFLASLTELE 198
R L +E+ FL +T+L+
Sbjct: 308 RKLIADEVDFLQHVTQLD 325
Score = 37.4 bits (85), Expect = 0.060
Identities = 50/190 (26%), Positives = 85/190 (44%), Gaps = 15/190 (7%)
Query: 3 VARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENL------EK 56
+AR+ L V++ L +L PNL +AD +L KLE+L E+
Sbjct: 440 LARLPERLERTSVEVLDVQHNQLLELPPNLLMKAD--SLRFLNASANKLESLPPATLSEE 497
Query: 57 CKRLIQLSVANNRLVRMMGVAKLT---LLRVLNLPHNSIGCVEGLK--ELVHLEWLNLAG 111
++Q N + V LT L++L++ +N + K +L LE ++L+G
Sbjct: 498 TNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSG 557
Query: 112 NNLKAM-EQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPR 170
N LKA+ I +C + + N I ++ +L +K + L N ++ + + P LP
Sbjct: 558 NKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTL-PENLPP 616
Query: 171 SLAILSLAEN 180
L L L N
Sbjct: 617 KLQELDLTGN 626
Score = 36.6 bits (83), Expect = 0.10
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 35/186 (18%)
Query: 30 PNLPCEA-DIHTLILDKNQIIKLENLEKCKR-LIQLSVANNRLVRMMGVAKLTLLRVLNL 87
P CE+ + L + NQI +L C L +L +N+L R+ + T + VL++
Sbjct: 398 PEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDV 457
Query: 88 PHNSIGCVEG--LKELVHLEWLNLAGNNLKAM------EQINSCTALQHLDLSDNNISQI 139
HN + + L + L +LN + N L+++ E+ NS LQ L L++N+++
Sbjct: 458 QHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNS--ILQELYLTNNSLT-- 513
Query: 140 GDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQ 199
K V L T H L IL +A N ++ S +A L ELE+
Sbjct: 514 ---DKCVPLLTGHPH-----------------LKILHMAYNRLQSF-PASKMAKLEELEE 552
Query: 200 LSIMNN 205
+ + N
Sbjct: 553 IDLSGN 558
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 51.6 bits (122), Expect = 3e-06
Identities = 59/226 (26%), Positives = 103/226 (45%), Gaps = 26/226 (11%)
Query: 18 VNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEK--CKRLIQLSVANNRLVRMMG 75
VN +GLQ+ ++ + L LDKNQI + + L LS+ N L +
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 76 -VAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAMEQINSCTA-LQHLDLS 132
+ L LR+LN+ HN I + + + +L ++ L N ++ C L+ L L
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 133 DNNISQIGD-LSKLVSLKTLLLHGNIITSLRMAPAYLPRSLA------ILSLAENEIRDL 185
N + I D L L +L+ L L N +T+ A +LP+ ++ ++S EIR+L
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIREL 325
Query: 186 ----------NEISFLA----SLTELEQLSIMNNPCVMATPSIPGF 217
N+++FLA L ++++L + +N + + I F
Sbjct: 326 KNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENF 371
Score = 37.7 bits (86), Expect = 0.046
Identities = 51/179 (28%), Positives = 87/179 (48%), Gaps = 37/179 (20%)
Query: 25 LQKLGPNLPCEADIHTLILDKN-------QIIKLENLEKCKRLIQLSVANNRLVRMMG-V 76
++K+ ++ +H LIL N ++ LENL+ L ++ N+L ++ +
Sbjct: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQV------LDLSENQLQKISSDI 598
Query: 77 AKLTLLRVLNLPHNS-IGCVEGLKELVHLEWLNLA---GNNLKAME-QINSCTALQHLDL 131
L ++ LN N I L +L LE LN++ G L + ++++ T L+ LD+
Sbjct: 599 CNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
Query: 132 SDNNISQ----IGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLN 186
S+N I + IG+L LVSL + N I +YLP SL L+ N+++ LN
Sbjct: 659 SNNAIREIPRNIGELRNLVSLHA---YNNQI-------SYLPPSL----LSLNDLQQLN 703
Score = 32.3 bits (72), Expect = 1.9
Identities = 36/148 (24%), Positives = 65/148 (43%), Gaps = 30/148 (20%)
Query: 17 VVNWSGQGLQKLGPNLPCEADIHTLILDKNQII----KLENLEKCKRLIQLSVANNRLVR 72
V++ S LQK+ ++ I L NQ I +L L+ ++L + +L R
Sbjct: 583 VLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTR 642
Query: 73 MMG-VAKLTLLRVLNLPHNSIGCVE------------------------GLKELVHLEWL 107
+ G ++ +T L+ L++ +N+I + L L L+ L
Sbjct: 643 LPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQL 702
Query: 108 NLAGNNLKAM-EQINSCTALQHLDLSDN 134
NL+GNNL A+ I + +L+ ++ DN
Sbjct: 703 NLSGNNLTALPSAIYNIFSLKEINFDDN 730
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 51.6 bits (122), Expect = 3e-06
Identities = 52/210 (24%), Positives = 90/210 (42%), Gaps = 27/210 (12%)
Query: 12 PGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQI--IKLENLEKCKRLIQLSVANNR 69
PG G +N + + + L P +++ L L N+I I+ + K LI L + NN
Sbjct: 351 PGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNN 410
Query: 70 LVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAM--EQINSCTALQ 127
+ + +N+ K L+ L WL + N L + E+ L+
Sbjct: 411 IA--------------TVENNTF------KNLLDLRWLYMDSNYLDTLSREKFAGLQNLE 450
Query: 128 HLDLSDNNISQI--GDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDL 185
+L++ N I I G + + L+ L+L+ N++ SL + + SL+ LSL N L
Sbjct: 451 YLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPV-DVFAGVSLSKLSLHNNYFMYL 509
Query: 186 NEISFLASLTELEQLSIMNNPCVMATPSIP 215
L LT + Q+ + NP + +P
Sbjct: 510 PVAGVLDQLTSIIQIDLHGNPWECSCTIVP 539
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 50.4 bits (119), Expect = 7e-06
Identities = 54/182 (29%), Positives = 88/182 (48%), Gaps = 18/182 (9%)
Query: 38 IHTLILDKNQI--IKLENLEKCKRLIQLSVANNRLV--------RMMGVAKLTLLRVLNL 87
++TL L N++ + + E +L +L + NN + R+ + +L L + L
Sbjct: 136 LNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRL 195
Query: 88 PHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQI--GDLSKL 145
+ S EGL V+L +LNL NLK + + + L+ L+LS N + I G L
Sbjct: 196 EYISEAAFEGL---VNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGL 252
Query: 146 VSLKTL-LLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMN 204
SL+ L L+H + T R A L +SL L+L+ N + L F L LE++ + +
Sbjct: 253 TSLRKLWLMHAQVATIERNAFDDL-KSLEELNLSHNNLMSLPHDLF-TPLHRLERVHLNH 310
Query: 205 NP 206
NP
Sbjct: 311 NP 312
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 50.1 bits (118), Expect = 9e-06
Identities = 55/181 (30%), Positives = 89/181 (49%), Gaps = 14/181 (7%)
Query: 38 IHTLI---LDKNQIIKL--ENLEKCKRLIQLSVANNRLVRM-MGVAK-LTLLRVLNLPHN 90
+H+L+ LD + I+ + + + + L L + NN + R+ G+ K L LR L L +N
Sbjct: 83 LHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYN 142
Query: 91 SIGCVEG--LKELVHLEWLNLAGNNLKAMEQ--INSCTALQHLDLSDNNISQIGD--LSK 144
+ V +LV +++LNL N L + AL+ LDLS+NNI +I +
Sbjct: 143 QVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQH 202
Query: 145 LVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMN 204
L +L L L N +T + + +SL LSL+ N I + +F L LE L + N
Sbjct: 203 LENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAF-KGLANLEYLLLKN 261
Query: 205 N 205
+
Sbjct: 262 S 262
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,843,586
Number of Sequences: 37866
Number of extensions: 1395381
Number of successful extensions: 4885
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 242
Number of HSP's that attempted gapping in prelim test: 4372
Number of HSP's gapped (non-prelim): 622
length of query: 865
length of database: 18,247,518
effective HSP length: 111
effective length of query: 754
effective length of database: 14,044,392
effective search space: 10589471568
effective search space used: 10589471568
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.