Search of human proteins with 30425553

Search of human proteins with 30425553

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
         (441 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                926   0.0  
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                352   3e-97
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]             312   4e-85
gi|194440719 chondroadherin-like [Homo sapiens]                       128   1e-29
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         122   6e-28
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...   120   2e-27
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...   120   2e-27
gi|51317373 netrin-G1 ligand [Homo sapiens]                           119   4e-27
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         116   4e-26
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           111   1e-24
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...   110   2e-24
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]      110   3e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   109   4e-24
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   109   4e-24
gi|12007646 nyctalopin precursor [Homo sapiens]                       105   1e-22
gi|188528675 slit homolog 1 [Homo sapiens]                            105   1e-22
gi|198041768 synleurin [Homo sapiens]                                 104   1e-22
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  104   2e-22
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s...   102   9e-22
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   100   3e-21
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...   100   4e-21
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...   100   4e-21
gi|88702793 slit-like 2 [Homo sapiens]                                100   4e-21
gi|153251229 chondroadherin precursor [Homo sapiens]                   99   6e-21
gi|225579152 insulin-like growth factor binding protein, acid la...    98   2e-20
gi|4826772 insulin-like growth factor binding protein, acid labi...    98   2e-20
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    98   2e-20
gi|11321571 slit homolog 3 [Homo sapiens]                              97   3e-20
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]                97   3e-20
gi|4759146 slit homolog 2 [Homo sapiens]                               95   1e-19

>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score =  926 bits (2393), Expect = 0.0
 Identities = 441/441 (100%), Positives = 441/441 (100%)

Query: 1   MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF 60
           MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF
Sbjct: 1   MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF 60

Query: 61  LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET 120
           LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET
Sbjct: 61  LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET 120

Query: 121 FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL 180
           FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL
Sbjct: 121 FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL 180

Query: 181 HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC 240
           HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC
Sbjct: 181 HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC 240

Query: 241 LAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAED 300
           LAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAED
Sbjct: 241 LAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAED 300

Query: 301 FRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPR 360
           FRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPR
Sbjct: 301 FRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPR 360

Query: 361 NRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQAS 420
           NRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQAS
Sbjct: 361 NRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQAS 420

Query: 421 SASSLGASLLAWTLGLAVTLR 441
           SASSLGASLLAWTLGLAVTLR
Sbjct: 421 SASSLGASLLAWTLGLAVTLR 441


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  352 bits (904), Expect = 3e-97
 Identities = 176/300 (58%), Positives = 217/300 (72%), Gaps = 2/300 (0%)

Query: 12  LLLVAAELPLGG-GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQ 70
           LLL+   LPL    CP  C CY +P TVSCQA+NF+++P  +P  ++R+FLQNN I  L+
Sbjct: 17  LLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLR 76

Query: 71  PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHAL 130
           PG F   ++TLW++SNN++ I+P TF     LEELDLGDNR LR+L P+TFQGL +L +L
Sbjct: 77  PGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSL 136

Query: 131 YLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGP 190
           +LY+C LS+LP  +F GL SLQYLYLQ+N + +LQDD+F DL NLSHLFLHGN+L  L  
Sbjct: 137 HLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTE 196

Query: 191 GTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFL 250
             FRGL +LDRLLLH N+LQ VH  AF  L RLT L+LFNNSL+ L GE LA L +LEFL
Sbjct: 197 HVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFL 256

Query: 251 RLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASP 310
           RLN NPW C CRAR LW W QR R SSS V C +P  R G+DL+ LR  DF+ C  PA+P
Sbjct: 257 RLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQACP-PAAP 315


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score =  312 bits (799), Expect = 4e-85
 Identities = 184/414 (44%), Positives = 232/414 (56%), Gaps = 21/414 (5%)

Query: 25  CPRDCVCYPAP-MTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPA--MVTL 81
           CP  CVCY  P +T SC      A+P GIP  S+R+FL  NRI  +    F     +  L
Sbjct: 27  CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86

Query: 82  WIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALP 141
           W++SN +  I  + F G   LE+LDL DN QLR++ P TF GL +LH L+L +CGL  L 
Sbjct: 87  WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146

Query: 142 AGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDR 201
            G+F GL +LQYLYLQDN ++ L DD F DL NL+HLFLHGN++ S+    FRGL +LDR
Sbjct: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206

Query: 202 LLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGC 261
           LLLH+N++  VH  AF DL RL TL+LF N+LS L  E LAPL AL++LRLN NPW C C
Sbjct: 207 LLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDC 266

Query: 262 RARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNC---TGPASP-------- 310
           RAR LW WLQ+FRGSSS VPC  P    G+DLK L A D + C   TGP  P        
Sbjct: 267 RARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATD 326

Query: 311 -HQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAG 369
              +        D A +     P  P  +     G  P    P  N + PR+ N  S  G
Sbjct: 327 EEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHIND-SPFG 385

Query: 370 A--GKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASS 421
              G   P L    P+      F   PT+ P+R+  C+R+   R+   + QA S
Sbjct: 386 TLPGSAEPPLTAVRPEGSEPPGF---PTSGPRRRPGCSRKNRTRSHCRLGQAGS 436


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  128 bits (321), Expect = 1e-29
 Identities = 124/413 (30%), Positives = 160/413 (38%), Gaps = 60/413 (14%)

Query: 10  LLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLL 69
           +LLLL  A       CP+ C+C  +   V+C+  N   +P+ IP  ++R+ LQ N + ++
Sbjct: 18  VLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVI 77

Query: 70  QPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127
               F   P +  L +    +  +    F G   L  L+L  N  LR L  E   GL  L
Sbjct: 78  PAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNH-LRELPQEALDGLGSL 136

Query: 128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWS 187
             L L    L  L  G FG L +L  L L  N + YL    F  L+ +  L L  N L  
Sbjct: 137 RRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSV 196

Query: 188 LGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS------------- 234
           L P    GL  L RL LH N+LQ +        R L  L L +N L+             
Sbjct: 197 LAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGL 256

Query: 235 ---------------------------ELQG---ECLAPL---GALEFLRLNGNPWDCGC 261
                                      +L+G   + L PL   G L  LRL GNP  CGC
Sbjct: 257 RELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGC 316

Query: 262 RARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTT 321
           +AR L EWL R R  S    C  P    G+ L  LR  D R C G A+  + +       
Sbjct: 317 QARPLLEWLARARVRSDGA-CQGPRRLRGEALDALRPWDLR-CPGDAAQEEEE-----LE 369

Query: 322 DRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQA 374
           +RA       P GP R  G      P  R     C         S  G G QA
Sbjct: 370 ERAVAGPRAPPRGPPRGPGEERAVAPCPRA----CVCVPESRHSSCEGCGLQA 418



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 87/335 (25%), Positives = 124/335 (37%), Gaps = 53/335 (15%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPA--MVTLW 82
           CPR CVC P     SC+     A+P G P D++ + L+ N    +    F     +V+L 
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455

Query: 83  IYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPA 142
           +    I  +      G   L  L L DN QL  L+    +G  +L  LYL +     +P 
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDN-QLAGLSAAALEGAPRLGYLYLERNRFLQVPG 514

Query: 143 GVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRL 202
                L SL  L+LQDN ++ L          L  ++L GN++  +  G       L++L
Sbjct: 515 AALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKL 574

Query: 203 LLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLG----------------- 245
            L  NQL+ V   A   L  L  L L  N L  L+     P+G                 
Sbjct: 575 HLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQIC 634

Query: 246 -------------------------------ALEFLRLNGNPWDCGCRARSLWEWLQRFR 274
                                           LE + L+ NP+ C C+   L  WL    
Sbjct: 635 PGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLN 694

Query: 275 GSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPAS 309
               A  C +P    GQ +K   A  F +C G A+
Sbjct: 695 LRVGAT-CATPPNARGQRVKAAAAV-FEDCPGWAA 727


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  122 bits (306), Expect = 6e-28
 Identities = 91/288 (31%), Positives = 132/288 (45%), Gaps = 32/288 (11%)

Query: 15  VAAELPLGGG------CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGL 68
           VA     GGG      CP  C C      V C   + A +P  IPV++  + LQ N I +
Sbjct: 41  VAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQV 100

Query: 69  LQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVK 126
           ++   F     +  L +  N +  I    F G   L  L+L DNR L T+  + F+ L K
Sbjct: 101 IRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR-LTTVPTQAFEYLSK 159

Query: 127 LHALYLYKCGLSALPAGVFGGLHSLQYLYLQD-NHIEYLQDDIFVDLVNLSHLFL----- 180
           L  L+L    + ++P+  F  + SL+ L L +   +EY+ +  F  LVNL +L L     
Sbjct: 160 LRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNL 219

Query: 181 -----------------HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRL 223
                             GN+L  + PG+F+GL +L +L L   Q+  +   AF DL+ L
Sbjct: 220 KDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSL 279

Query: 224 TTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQ 271
             L L +N+L  L  +   PL  LE + LN NPW C C    L  WL+
Sbjct: 280 EELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK 327


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score =  120 bits (301), Expect = 2e-27
 Identities = 119/412 (28%), Positives = 174/412 (42%), Gaps = 71/412 (17%)

Query: 4   KGCCVELLLLLVAAELPLGGG---CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF 60
           KG  V L+LL     + L G    CP++C C      V C++H FA IPE I   S+ + 
Sbjct: 10  KGMSVVLVLLPTLLLVMLTGAQRACPKNCRC--DGKIVYCESHAFADIPENISGGSQGLS 67

Query: 61  LQNNRIGLLQPGHFSPAMVTLWIY--------------------------SNNITYIHPS 94
           L+ N I  L+   F+     +W+Y                          SN ITY+H  
Sbjct: 68  LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127

Query: 95  TFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVF--------- 145
           TF    +L  LDL  N+ L+TL  E F+GL KL  L+L    L  +P  VF         
Sbjct: 128 TFHPVPNLRNLDLSYNK-LQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFL 186

Query: 146 ---------------GGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGP 190
                           GL  L+ L+L+ N    +    F  L NL  ++L  N++ S+  
Sbjct: 187 DLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQ 246

Query: 191 G---TFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGAL 247
           G   T+  L NLD   L  N +Q +    F  L  L  L L +N L+ +  E +    +L
Sbjct: 247 GLTWTWSSLHNLD---LSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303

Query: 248 EFLRLNGNPWDCGCRARSLWEWLQRFRGS-SSAVPCVSPGLRHGQDLKLLRA-EDFRNCT 305
             + L+GN W+C      L+ WL+ F+G+  S + C  P  +H Q  K+  A E +  C+
Sbjct: 304 ISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGP--KHIQGEKVSDAVETYNICS 361

Query: 306 GPASPHQIKSHTLTTTDR----AARKEHHSPHGPTRSKGHPHGPRPGHRKPG 353
                +  +SH +  T +      R     P   T+S      P PG + PG
Sbjct: 362 EVQVVNTERSHLVPQTPQKPLIIPRPTIFKP-DVTQSTFETPSPSPGFQIPG 412


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score =  120 bits (301), Expect = 2e-27
 Identities = 119/412 (28%), Positives = 174/412 (42%), Gaps = 71/412 (17%)

Query: 4   KGCCVELLLLLVAAELPLGGG---CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF 60
           KG  V L+LL     + L G    CP++C C      V C++H FA IPE I   S+ + 
Sbjct: 10  KGMSVVLVLLPTLLLVMLTGAQRACPKNCRC--DGKIVYCESHAFADIPENISGGSQGLS 67

Query: 61  LQNNRIGLLQPGHFSPAMVTLWIY--------------------------SNNITYIHPS 94
           L+ N I  L+   F+     +W+Y                          SN ITY+H  
Sbjct: 68  LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127

Query: 95  TFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVF--------- 145
           TF    +L  LDL  N+ L+TL  E F+GL KL  L+L    L  +P  VF         
Sbjct: 128 TFHPVPNLRNLDLSYNK-LQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFL 186

Query: 146 ---------------GGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGP 190
                           GL  L+ L+L+ N    +    F  L NL  ++L  N++ S+  
Sbjct: 187 DLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQ 246

Query: 191 G---TFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGAL 247
           G   T+  L NLD   L  N +Q +    F  L  L  L L +N L+ +  E +    +L
Sbjct: 247 GLTWTWSSLHNLD---LSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303

Query: 248 EFLRLNGNPWDCGCRARSLWEWLQRFRGS-SSAVPCVSPGLRHGQDLKLLRA-EDFRNCT 305
             + L+GN W+C      L+ WL+ F+G+  S + C  P  +H Q  K+  A E +  C+
Sbjct: 304 ISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGP--KHIQGEKVSDAVETYNICS 361

Query: 306 GPASPHQIKSHTLTTTDR----AARKEHHSPHGPTRSKGHPHGPRPGHRKPG 353
                +  +SH +  T +      R     P   T+S      P PG + PG
Sbjct: 362 EVQVVNTERSHLVPQTPQKPLIIPRPTIFKP-DVTQSTFETPSPSPGFQIPG 412


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  119 bits (299), Expect = 4e-27
 Identities = 87/294 (29%), Positives = 140/294 (47%), Gaps = 26/294 (8%)

Query: 11  LLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQ 70
           L LLV A L     CP  C C      V C   N   +P+GI  ++  + L  N+I +++
Sbjct: 33  LQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIK 92

Query: 71  PGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLH 128
              F     +  L +  N+I  I    F G  +L  L+L DNR L T+    F  L KL 
Sbjct: 93  VNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNR-LTTIPNGAFVYLSKLK 151

Query: 129 ALYLYKCGLSALPAGVFGGLHSLQYLYLQD-NHIEYLQDDIFVDLVNLSHLFL------- 180
            L+L    + ++P+  F  + SL+ L L +   + Y+ +  F  L NL +L L       
Sbjct: 152 ELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLRE 211

Query: 181 ---------------HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTT 225
                           GN L ++ PG+F+GL++L +L + ++Q+Q +   AF +L+ L  
Sbjct: 212 IPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVE 271

Query: 226 LFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSA 279
           + L +N+L+ L  +   PL  LE + L+ NPW+C C    L  W++    S++A
Sbjct: 272 INLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTA 325


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  116 bits (291), Expect = 4e-26
 Identities = 92/271 (33%), Positives = 113/271 (41%), Gaps = 54/271 (19%)

Query: 2   LRKGCCVELLLLLVAAELPL-GGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVF 60
           LR    + LLLLL    LPL   GCP  C CY A  TV C A     +P GIP  ++ +F
Sbjct: 3   LRAPALLPLLLLL----LPLRAAGCPAACRCYSA--TVECGALRLRVVPLGIPPGTQTLF 56

Query: 61  LQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPET 120
           LQ+N I  L+PG                                           LAP  
Sbjct: 57  LQDNNIARLEPG------------------------------------------ALAP-- 72

Query: 121 FQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL 180
              L  L  LYL+   L AL AG F     L  L L  N +  L+   FV L  L  L+L
Sbjct: 73  ---LAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYL 129

Query: 181 HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGEC 240
            GN+L  L   TF  L  L  L L EN ++ +  +A   L  L  L L  N L  +  E 
Sbjct: 130 AGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREA 189

Query: 241 LAPLGALEFLRLNGNPWDCGCRARSLWEWLQ 271
           L PL +L+ LRL  NPW C C    L  W++
Sbjct: 190 LQPLASLQVLRLTENPWRCDCALHWLGAWIK 220


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  111 bits (277), Expect = 1e-24
 Identities = 93/328 (28%), Positives = 141/328 (42%), Gaps = 30/328 (9%)

Query: 8   VELLLLLVAAELPLGG-GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRI 66
           V +L   +AA    G   CP  C C      V C     + +P+GIP ++  + L  N I
Sbjct: 28  VWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNI 87

Query: 67  GLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGL 124
            ++Q   F     +  L +  N+I  I    F G   L  L+L DN  L  +    F+ L
Sbjct: 88  QMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDN-WLTVIPSGAFEYL 146

Query: 125 VKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQD-NHIEYLQDDIFVDLVNLSHLFL--- 180
            KL  L+L    + ++P+  F  + SL  L L +   +EY+ +  F  L NL +L L   
Sbjct: 147 SKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMC 206

Query: 181 -------------------HGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLR 221
                               GN    + PG+F GL +L +L +  +Q+  +   AF  L 
Sbjct: 207 NIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLA 266

Query: 222 RLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRF--RGSSSA 279
            L  L L +N+LS L  +   PL  L  L L+ NPW+C C    L  WL+ +    S+  
Sbjct: 267 SLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCC 326

Query: 280 VPCVSPGLRHGQDLKLLRAEDFRNCTGP 307
             C +P    G+ L  +    F+ C+ P
Sbjct: 327 GRCHAPMHMRGRYLVEVDQASFQ-CSAP 353


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score =  110 bits (276), Expect = 2e-24
 Identities = 91/332 (27%), Positives = 138/332 (41%), Gaps = 55/332 (16%)

Query: 14  LVAAELP-LGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPG 72
           +V   LP LG  CP  C C    +   C +  F ++P      S  + L++N I  L+  
Sbjct: 22  MVLKMLPALGMACPPKCRC--EKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERD 79

Query: 73  HFSPAMVTLWIY--------------------------SNNITYIHPSTFEGFVHLEELD 106
            F+      W++                          SN I Y+  +TF   ++L+ LD
Sbjct: 80  QFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLD 139

Query: 107 LGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQD 166
           L  N QL +L PE F GL KL  L+L    L  +P  +F    SL++L L  N +  L  
Sbjct: 140 LSFN-QLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLAR 198

Query: 167 DIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQL-------QW-------- 211
           + F  L+ L  L L  N+L  +    F  L +L  L L  N++       +W        
Sbjct: 199 NGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKL 258

Query: 212 ---------VHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCR 262
                    +    F  +  L  L + NN L+ L  + L  L +L  + L+GN W+C  R
Sbjct: 259 DLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSAR 318

Query: 263 ARSLWEWLQRFRGS-SSAVPCVSPGLRHGQDL 293
             +L  WL  F+G    ++ C SP    G+D+
Sbjct: 319 ICALASWLGSFQGRWEHSILCHSPDHTQGEDI 350


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score =  110 bits (274), Expect = 3e-24
 Identities = 92/326 (28%), Positives = 143/326 (43%), Gaps = 53/326 (16%)

Query: 6   CCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNR 65
           C +    ++     P G  CPR C CY  P  V C      +IP+ IP + ER+ L    
Sbjct: 10  CLLVSFAVICLVATPGGKACPRRCACY-MPTEVHCTFRYLTSIPDSIPPNVERINL---- 64

Query: 66  IGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLV 125
                 G+            N++  +  + F G   LE L L  N  + T+  +TF  L 
Sbjct: 65  ------GY------------NSLVRLMETDFSGLTKLELLMLHSNG-IHTIPDKTFSDLQ 105

Query: 126 KLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKL 185
            L  L +    +  L    F GL SL  L++  N+IE++  ++F  L  L  + L GN+L
Sbjct: 106 ALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQL 165

Query: 186 WSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLG 245
             L P TF   V+L  L + +             +  +  L+L +N L+ L  E ++ + 
Sbjct: 166 TKLHPDTF---VSLSYLQIFK-------------ISFIKFLYLSDNFLTSLPQEMVSYMP 209

Query: 246 ALEFLRLNGNPWDCGCRARSLWEWLQ---------RFRGSSSAVP---CVSPGLRHGQDL 293
            L+ L L+GNPW C C  + L +W+Q         + R  SSA     C++P    G+ L
Sbjct: 210 DLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPL 269

Query: 294 KLLRAEDFRNCTGPASPHQIKSHTLT 319
            ++ A  F+ C  P     +KS +LT
Sbjct: 270 AMVSAAAFQ-CAKPTIDSSLKSKSLT 294


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  109 bits (273), Expect = 4e-24
 Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 50/266 (18%)

Query: 81  LWIYSNNITYIHPSTFEGFVHLEELDLGDNR-----------------------QLRTLA 117
           L +Y N +T I   TF+G V+L+EL L  N+                        +  L 
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267

Query: 118 PETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSH 177
           P  F  L +L+ L L+   L  L  G+FG + +L+ L+L DNHI  L D++F +L  L  
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327

Query: 178 LFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQ 237
           L L  N++  + PG F GL  L  L LH N LQ +    F  L  L  + L NN L +L 
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387

Query: 238 GECLA------------------PLGALEF------LRLNGNPWDCGCRARSLWEWL--- 270
           G   A                  PLG  +       LRL  NPW C      L  WL   
Sbjct: 388 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 447

Query: 271 QRFRGSSSAVPCVSPGLRHGQDLKLL 296
           Q   G+ +   C SP    GQ L ++
Sbjct: 448 QPRLGTDTVPVCFSPANVRGQSLIII 473



 Score =  105 bits (263), Expect = 6e-23
 Identities = 87/275 (31%), Positives = 117/275 (42%), Gaps = 32/275 (11%)

Query: 11  LLLLVAAELPLGG----GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRI 66
           LLLLV  +    G    GCP +C C  A   V C      A+P  +P ++  + + N  I
Sbjct: 13  LLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHI 71

Query: 67  GLLQPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGL 124
             L    F    A++ L I  N ++ I P  F     L  L L +N+ L+ L    FQGL
Sbjct: 72  TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK-LQVLPIGLFQGL 130

Query: 125 VKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNK 184
             L +L L    L  +    F    +L+ L L  NH+EY+ D  F  LV L+ L L  N 
Sbjct: 131 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 190

Query: 185 LWSLGP------------------------GTFRGLVNLDRLLLHENQLQWVHHKAFHDL 220
           L  + P                        GTF GLVNL  L L +NQ+  +    FH+ 
Sbjct: 191 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 250

Query: 221 RRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
             L  L+L NN +S+L       L  L  L L GN
Sbjct: 251 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGN 285



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 3/152 (1%)

Query: 58  RVFLQNNRIGLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRT 115
           R+ L  N +  L  G F P   +  LW+Y N+I+ +  + F     L+ L L  N Q+  
Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN-QISF 337

Query: 116 LAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNL 175
           ++P  F GL +L  L L+   L  L   VF  L +LQ + LQ+N +  L  +IF ++  L
Sbjct: 338 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL 397

Query: 176 SHLFLHGNKLWSLGPGTFRGLVNLDRLLLHEN 207
             + L  N+L +L  G F  L  L  L L++N
Sbjct: 398 MAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  109 bits (273), Expect = 4e-24
 Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 50/266 (18%)

Query: 81  LWIYSNNITYIHPSTFEGFVHLEELDLGDNR-----------------------QLRTLA 117
           L +Y N +T I   TF+G V+L+EL L  N+                        +  L 
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261

Query: 118 PETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSH 177
           P  F  L +L+ L L+   L  L  G+FG + +L+ L+L DNHI  L D++F +L  L  
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321

Query: 178 LFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQ 237
           L L  N++  + PG F GL  L  L LH N LQ +    F  L  L  + L NN L +L 
Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381

Query: 238 GECLA------------------PLGALEF------LRLNGNPWDCGCRARSLWEWL--- 270
           G   A                  PLG  +       LRL  NPW C      L  WL   
Sbjct: 382 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLN 441

Query: 271 QRFRGSSSAVPCVSPGLRHGQDLKLL 296
           Q   G+ +   C SP    GQ L ++
Sbjct: 442 QPRLGTDTVPVCFSPANVRGQSLIII 467



 Score =  105 bits (263), Expect = 6e-23
 Identities = 87/275 (31%), Positives = 117/275 (42%), Gaps = 32/275 (11%)

Query: 11  LLLLVAAELPLGG----GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRI 66
           LLLLV  +    G    GCP +C C  A   V C      A+P  +P ++  + + N  I
Sbjct: 7   LLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHI 65

Query: 67  GLLQPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGL 124
             L    F    A++ L I  N ++ I P  F     L  L L +N+ L+ L    FQGL
Sbjct: 66  TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK-LQVLPIGLFQGL 124

Query: 125 VKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNK 184
             L +L L    L  +    F    +L+ L L  NH+EY+ D  F  LV L+ L L  N 
Sbjct: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184

Query: 185 LWSLGP------------------------GTFRGLVNLDRLLLHENQLQWVHHKAFHDL 220
           L  + P                        GTF GLVNL  L L +NQ+  +    FH+ 
Sbjct: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 244

Query: 221 RRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
             L  L+L NN +S+L       L  L  L L GN
Sbjct: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGN 279



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 3/152 (1%)

Query: 58  RVFLQNNRIGLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRT 115
           R+ L  N +  L  G F P   +  LW+Y N+I+ +  + F     L+ L L  N Q+  
Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN-QISF 331

Query: 116 LAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNL 175
           ++P  F GL +L  L L+   L  L   VF  L +LQ + LQ+N +  L  +IF ++  L
Sbjct: 332 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL 391

Query: 176 SHLFLHGNKLWSLGPGTFRGLVNLDRLLLHEN 207
             + L  N+L +L  G F  L  L  L L++N
Sbjct: 392 MAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  105 bits (261), Expect = 1e-22
 Identities = 95/344 (27%), Positives = 126/344 (36%), Gaps = 76/344 (22%)

Query: 25  CPRDCVCYPAPM--TVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFS--PAMVT 80
           CP  C C       +V C       +P  +P ++  + L  N +  L    F   P++  
Sbjct: 31  CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRR 90

Query: 81  LWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSAL 140
           L +  NN+++I P  F+G   L EL L  N  LR L   TF  L +L  L L  C L ++
Sbjct: 91  LSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSV 150

Query: 141 PAGVFG-----------------------------------------------GLHSLQY 153
           P  +                                                 GL  L+ 
Sbjct: 151 PERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRS 210

Query: 154 LYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVH 213
           L LQ N +  +    F D   L HL L+ N L  L    FRGL  L  L L  N L  V 
Sbjct: 211 LSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA 270

Query: 214 HKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNG------------------- 254
              F DL  L  L+L  NS++ ++      L  L  L LNG                   
Sbjct: 271 RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGR 330

Query: 255 -----NPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDL 293
                NPW C CR   L +W++   G  + VPC SPG   G DL
Sbjct: 331 LFLFRNPWCCDCRLEWLRDWMEG-SGRVTDVPCASPGSVAGLDL 373


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  105 bits (261), Expect = 1e-22
 Identities = 68/185 (36%), Positives = 91/185 (49%), Gaps = 25/185 (13%)

Query: 23  GGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLW 82
           G CP  C C      V C+     AIP  +P     + L+ N I  + PG FSP      
Sbjct: 280 GSCPAMCTCSNG--IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSP------ 331

Query: 83  IYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPA 142
                           +  L  +DL +N Q+  +AP+ FQGL  L++L LY   ++ LP 
Sbjct: 332 ----------------YRKLRRIDLSNN-QIAEIAPDAFQGLRSLNSLVLYGNKITDLPR 374

Query: 143 GVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRL 202
           GVFGGL++LQ L L  N I  ++ D F DL NLS L L+ NK+ SL  GTF  L  +  L
Sbjct: 375 GVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTL 434

Query: 203 LLHEN 207
            L +N
Sbjct: 435 HLAQN 439



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 84/313 (26%), Positives = 127/313 (40%), Gaps = 51/313 (16%)

Query: 9   ELLLLLVAAELPLGGG-CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIG 67
           EL LLL AA   LG   CP  C C     TV C      AIP+ IP ++ER+ L      
Sbjct: 17  ELWLLLWAAAWRLGASACPALCTC--TGTTVDCHGTGLQAIPKNIPRNTERLELN----- 69

Query: 68  LLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127
                             NNIT IH + F G   L  L L +N+                
Sbjct: 70  -----------------GNNITRIHKNDFAGLKQLRVLQLMENQ---------------- 96

Query: 128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWS 187
                    + A+  G F  +  L+ L L  N +  L + +F +   LS L L  N + +
Sbjct: 97  ---------IGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQA 147

Query: 188 LGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGAL 247
           +    FRG  +L  L L +NQ+  +   AF  LR L  L L NN+++ +       +  L
Sbjct: 148 IPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKL 207

Query: 248 EFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGP 307
              RL+ N   C C    L +WL++         C  P    G ++  ++  +F +C+G 
Sbjct: 208 RTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEF-SCSGQ 266

Query: 308 ASPHQIKSHTLTT 320
               ++ + TL++
Sbjct: 267 GEAGRVPTCTLSS 279



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 52/167 (31%), Positives = 86/167 (51%)

Query: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG 195
           G+ ++P G F     L+ + L +N I  +  D F  L +L+ L L+GNK+  L  G F G
Sbjct: 320 GIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGG 379

Query: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
           L  L  LLL+ N++  +   AF DL+ L+ L L++N +  L       L A++ L L  N
Sbjct: 380 LYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439

Query: 256 PWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFR 302
           P+ C C  + L ++L+     +S   C SP     + +  ++++ FR
Sbjct: 440 PFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFR 486



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 47/160 (29%), Positives = 81/160 (50%)

Query: 143 GVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRL 202
           G+F  L  L+ + L +N +  ++D  F    ++S L L  N+L S+  G FRGL  L  L
Sbjct: 559 GMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618

Query: 203 LLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCR 262
           +L  N++  +H+ +F  LR +  L L++N ++ +       L +L  L L  NP++C C+
Sbjct: 619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQ 678

Query: 263 ARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFR 302
              L  WL++ +  +    C +P       L+ +   DFR
Sbjct: 679 LAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR 718



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 53/194 (27%), Positives = 87/194 (44%), Gaps = 30/194 (15%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP  C C      V C +     IPE IP  +  + L NN I +L+              
Sbjct: 513 CPHKCRC--EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEA------------- 557

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
                      F+   HL++++L +N+ +  +    F+G   +  L+L    L ++ +G+
Sbjct: 558 --------TGMFKKLTHLKKINLSNNK-VSEIEDGAFEGAASVSELHLTANQLESIRSGM 608

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLL 204
           F GL  L+ L L++N I  + +D F  L N+  L L+ N++ ++ PG F  L +L  L L
Sbjct: 609 FRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNL 668

Query: 205 HEN------QLQWV 212
             N      QL W+
Sbjct: 669 LANPFNCNCQLAWL 682



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 49/162 (30%), Positives = 77/162 (47%), Gaps = 26/162 (16%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP++C C      V C   +  A+P+GIP +   ++L  N+  L+ PG  S         
Sbjct: 734 CPQECACLDT--VVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV-PGQLST-------- 782

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
                         F +L+ +DL +N+ + +L+  +F  + +L  L L    L  +P   
Sbjct: 783 --------------FKYLQLVDLSNNK-ISSLSNSSFTNMSQLTTLILSYNALQCIPPLA 827

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLW 186
           F GL SL+ L L  N I  LQ+ IF D+ +LSHL +  N L+
Sbjct: 828 FQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLY 869



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 54/175 (30%), Positives = 76/175 (43%), Gaps = 13/175 (7%)

Query: 137 LSALPAGVFGGLHSLQYLYLQDNHIEYLQDDI----FVDLVNLSHLFLHGNKLWSLGPGT 192
           L ALP G+     ++  LYL  N    +   +    ++ LV+LS+     NK+ SL   +
Sbjct: 752 LRALPKGI---PKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSN-----NKISSLSNSS 803

Query: 193 FRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRL 252
           F  +  L  L+L  N LQ +   AF  LR L  L L  N +S LQ    A + +L  L +
Sbjct: 804 FTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAI 863

Query: 253 NGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGP 307
             NP  C C  R L  W++          C  P    G+ L    A+ F  C GP
Sbjct: 864 GANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKF-ECQGP 917



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 27/85 (31%), Positives = 42/85 (49%)

Query: 175 LSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS 234
           ++ + L  N + S+ PG F     L R+ L  NQ+  +   AF  LR L +L L+ N ++
Sbjct: 311 MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKIT 370

Query: 235 ELQGECLAPLGALEFLRLNGNPWDC 259
           +L       L  L+ L LN N  +C
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINC 395


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  104 bits (260), Expect = 1e-22
 Identities = 80/248 (32%), Positives = 121/248 (48%), Gaps = 9/248 (3%)

Query: 11  LLLLVAAELPLGGGCPRDC-VCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLL 69
           LLLL+  E+    GC   C +C      ++C+    ++IP+  P  +  ++L  N I  +
Sbjct: 21  LLLLLHKEIL---GCSSVCQLC--TGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYI 75

Query: 70  QPGHFSP--AMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127
                +   ++V L++ ++NI Y++P  F    HL  L L +N  ++ L P  F+GL+ L
Sbjct: 76  NESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF-IKRLDPGIFKGLLNL 134

Query: 128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWS 187
             LYL    +S +P GVF  L S+QYL LQ N +  L    FV +V L  L L  N +  
Sbjct: 135 RNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR 194

Query: 188 LGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGAL 247
           +    F+ L NL  L L  N L  V   AF  L+ L  L L +N +  +Q      L  L
Sbjct: 195 ISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANL 254

Query: 248 EFLRLNGN 255
           E+L L  +
Sbjct: 255 EYLLLKNS 262



 Score =  103 bits (258), Expect = 2e-22
 Identities = 87/274 (31%), Positives = 132/274 (48%), Gaps = 19/274 (6%)

Query: 41  QAHNFAAIPEGI---PVDSERVFLQNNRIGLLQPGHF--SPAMVTLWIYSNNITYIHPST 95
           Q +  + +P G+    V  + + LQ NR+ +L  G F    A+  L + +NNI  I  S 
Sbjct: 140 QYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESG 199

Query: 96  FEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLY 155
           F+   +L  L LG N  L  +    F+ L  L  L L    + A+    F GL +L+YL 
Sbjct: 200 FQHLENLACLYLGSNN-LTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLL 258

Query: 156 LQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHK 215
           L+++ I  +  D F  + NL HL L  N L +L   TF  L NL  L L  N++  + + 
Sbjct: 259 LKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDND 318

Query: 216 AFHDL-RRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFR 274
            F ++   L  L L  N+L+ L    L PL +L  L+ N NPW+C C+   L +WL    
Sbjct: 319 TFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWL---- 374

Query: 275 GSSSAVP----CVSPGLRHGQDLKLLRAEDFRNC 304
            +SSA+     C +P    G+ L+ +   +  NC
Sbjct: 375 -ASSAITLNIYCQNPPSMRGRALRYI---NITNC 404



 Score =  101 bits (251), Expect = 2e-21
 Identities = 65/186 (34%), Positives = 99/186 (53%), Gaps = 1/186 (0%)

Query: 71  PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHAL 130
           P +F  + V L++  NNI+YI+ S   G   L  L L DN  +  + P+ F  L  L+ L
Sbjct: 55  PKNFPESTVFLYLTGNNISYINESELTGLHSLVALYL-DNSNILYVYPKAFVQLRHLYFL 113

Query: 131 YLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGP 190
           +L    +  L  G+F GL +L+ LYLQ N + ++   +F DLV++ +L L  N+L  LG 
Sbjct: 114 FLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGS 173

Query: 191 GTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFL 250
           GTF G+V L  L L  N +  +    F  L  L  L+L +N+L+++       L +L  L
Sbjct: 174 GTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRL 233

Query: 251 RLNGNP 256
            L+ NP
Sbjct: 234 SLSHNP 239


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  104 bits (259), Expect = 2e-22
 Identities = 62/171 (36%), Positives = 93/171 (54%), Gaps = 4/171 (2%)

Query: 140 LPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNL 199
           +P   F  L +L  L L +NHI  +  + F  L NL +L+L+ N++ +L   TF+GL++L
Sbjct: 65  IPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISL 124

Query: 200 DRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDC 259
           + L +H NQL+ +  + F DL RL  LFL NN LS++     + L +L+ LRL+ N   C
Sbjct: 125 EHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVC 184

Query: 260 GCRARSLWEWLQRFR---GSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGP 307
            C    L E LQ F     + +A  C  P   HG+ +  +  E+F NC  P
Sbjct: 185 DCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEF-NCQSP 234



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 72/203 (35%), Positives = 98/203 (48%), Gaps = 27/203 (13%)

Query: 7   CVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRI 66
           C   L LL    LP G  CP  C+C+ +  TV C       IP+ +P  +  + L+ NRI
Sbjct: 7   CWTTLFLLAGWCLP-GLPCPSRCLCFKS--TVRCMHLMLDHIPQ-VPQQTTVLDLRFNRI 62

Query: 67  GLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVK 126
             + PG                     S F+   +L  L L +N  +R ++   F+GL  
Sbjct: 63  REI-PG---------------------SAFKKLKNLNTLLLNNNH-IRKISRNAFEGLEN 99

Query: 127 LHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLW 186
           L  LYLYK  + AL    F GL SL++LY+  N +E LQ + F DL+ L  LFLH NKL 
Sbjct: 100 LLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLS 159

Query: 187 SLGPGTFRGLVNLDRLLLHENQL 209
            +  G+F  L +L RL L  N L
Sbjct: 160 KIPAGSFSNLDSLKRLRLDSNAL 182


>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
           sapiens]
          Length = 522

 Score =  102 bits (253), Expect = 9e-22
 Identities = 95/362 (26%), Positives = 150/362 (41%), Gaps = 57/362 (15%)

Query: 1   MLRKGCCVELLLLLVAAE-LPLG-GGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSER 58
           +LR+   V L LL    + LP    GCP+ C C      + C+A N    P  +      
Sbjct: 13  LLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRC--EGRLLYCEALNLTEAPHNLS-GLLG 69

Query: 59  VFLQNNRIGLLQPGHFSPAMVTLWIY--------------------------SNNITYIH 92
           + L+ N +  L+ G F+  M   W+Y                          SN IT + 
Sbjct: 70  LSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLP 129

Query: 93  PSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQ 152
            +TF    +L  +DL  N+ L+ LAP+ F GL KL  L++    +  +P  +F    SL+
Sbjct: 130 NTTFRPMPNLRSVDLSYNK-LQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLK 188

Query: 153 YLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLV--------------- 197
           +L +  N ++ L  + F  L  L+ L L  N L  +    F  L+               
Sbjct: 189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV 248

Query: 198 --------NLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEF 249
                   NL+++ L  N+++++    F  +  L +L L +N L+ ++   L    +L  
Sbjct: 249 VSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTS 308

Query: 250 LRLNGNPWDCGCRARSLWEWLQRFRGS-SSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPA 308
           + L GN WDCG    +L  WL  F+G     + C SP    G+D+ L     F  C   A
Sbjct: 309 ITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDV-LDAVYAFHLCEDGA 367

Query: 309 SP 310
            P
Sbjct: 368 EP 369


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  100 bits (249), Expect = 3e-21
 Identities = 102/389 (26%), Positives = 141/389 (36%), Gaps = 99/389 (25%)

Query: 6   CCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNR 65
           C + L LLL+ A  P  GGCP  C C      V+C      A+P+GIP ++  + L  NR
Sbjct: 6   CVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNR 65

Query: 66  IGLLQPGHFS--PAMVTLWIYSNNITYIHPS----------------------------- 94
           I  L PG  +  PA+  L +  N I ++ P                              
Sbjct: 66  IRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRL 125

Query: 95  -------------------TFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKC 135
                              TF+    L  L++GDN  L  ++   F GL+ L  L L +C
Sbjct: 126 DNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDN-DLVFVSRRAFAGLLALEELTLERC 184

Query: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFL-HGNKLWSLGPGTFR 194
            L+AL     G L SL  L L+   I  L+D  F  L  L HL + +   L  +  G+ R
Sbjct: 185 NLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLR 244

Query: 195 GL-----------------------VNLDRLLLHENQLQWVHHKAFHDLRRLTTLF---- 227
           GL                        +L  L L  N +  V   +F DL RL  L     
Sbjct: 245 GLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGA 304

Query: 228 --------------------LFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLW 267
                               L NN LS L+      +  LE LR++GNP  C CR   + 
Sbjct: 305 LLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIV 364

Query: 268 EWLQRFRGSSSAVPCVSPGLRHGQDLKLL 296
           +  +          C +P    G  L+ L
Sbjct: 365 QRRKTLNFDGRLPACATPAEVRGDALRNL 393


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 102/344 (29%), Positives = 142/344 (41%), Gaps = 60/344 (17%)

Query: 11  LLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIG--- 67
           L L VA    +   CP  C C      + C      +IP GIP D+  ++LQNN+I    
Sbjct: 17  LFLQVAPLSVMAKSCPSVCRCDAG--FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74

Query: 68  -------LLQ--------------PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELD 106
                  LL+              P +    +  L +  NNI  I   +     +LEEL 
Sbjct: 75  IPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELH 134

Query: 107 LGDNRQLRTLAPE-TFQGLVKLHALYLYKCGLSALPAGV--------------------- 144
           L DN        E  F+    L  L+L +  LS +P G+                     
Sbjct: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194

Query: 145 FGGLHSLQYLYLQDNHIEY--LQDDIFVDLVNLSHLFLHGNKLWSLG---PGTFRGLVNL 199
             GL SL+ L L  N +    L D +F +LVNL+ L L  N L +     PGT     NL
Sbjct: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT-----NL 249

Query: 200 DRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDC 259
            +L L +N +  V   AF  LR+L  L + NN+LS L       L  +  L L  NPW C
Sbjct: 250 RKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYC 309

Query: 260 GCRARSLWEWLQRF--RGSSSAVPCVSPGLRHGQDLKLLRAEDF 301
           GC+ + + +WLQ    + +   + C +P    G  +K L AE F
Sbjct: 310 GCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELF 353


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 102/344 (29%), Positives = 142/344 (41%), Gaps = 60/344 (17%)

Query: 11  LLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIG--- 67
           L L VA    +   CP  C C      + C      +IP GIP D+  ++LQNN+I    
Sbjct: 17  LFLQVAPLSVMAKSCPSVCRCDAG--FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74

Query: 68  -------LLQ--------------PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELD 106
                  LL+              P +    +  L +  NNI  I   +     +LEEL 
Sbjct: 75  IPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELH 134

Query: 107 LGDNRQLRTLAPE-TFQGLVKLHALYLYKCGLSALPAGV--------------------- 144
           L DN        E  F+    L  L+L +  LS +P G+                     
Sbjct: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194

Query: 145 FGGLHSLQYLYLQDNHIEY--LQDDIFVDLVNLSHLFLHGNKLWSLG---PGTFRGLVNL 199
             GL SL+ L L  N +    L D +F +LVNL+ L L  N L +     PGT     NL
Sbjct: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT-----NL 249

Query: 200 DRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDC 259
            +L L +N +  V   AF  LR+L  L + NN+LS L       L  +  L L  NPW C
Sbjct: 250 RKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYC 309

Query: 260 GCRARSLWEWLQRF--RGSSSAVPCVSPGLRHGQDLKLLRAEDF 301
           GC+ + + +WLQ    + +   + C +P    G  +K L AE F
Sbjct: 310 GCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELF 353


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 101/342 (29%), Positives = 140/342 (40%), Gaps = 53/342 (15%)

Query: 10  LLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLL 69
           L LLL+ A  P   GCP  C C   P TV C A     +P  +P D+  +++  N I +L
Sbjct: 9   LPLLLLLALGPGVQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITML 67

Query: 70  QPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127
             G F+  P +  L +  N I  +    F+   +L  LDL  NR L  +  ETF+GL +L
Sbjct: 68  DAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANR-LHEITNETFRGLRRL 126

Query: 128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQ--------------------DD 167
             LYL K  +  +  G F  L  L  L LQDN +  L                     + 
Sbjct: 127 ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEP 186

Query: 168 IFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLF 227
             +D  N+  L L G  L  L  G F  L NL  L + +NQL+ V       LR LT L 
Sbjct: 187 GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-PVIRGLRGLTRLR 245

Query: 228 LFNNS-LSELQGECLAPLGALEFLRLNG------------------------NPWDCGCR 262
           L  N+ +++L+ E LA L AL+ L ++                         NP++C C 
Sbjct: 246 LAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCP 305

Query: 263 ARSLWEWLQRFR---GSSSAVPCVSPGLRHGQDLKLLRAEDF 301
                 W++       S     C  P    G+ L  L   DF
Sbjct: 306 LSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADF 347


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 94/347 (27%), Positives = 135/347 (38%), Gaps = 54/347 (15%)

Query: 10  LLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLL 69
           L L L+A  LP    CP++C C+     V C       IP+ +   ++ + LQ N   +L
Sbjct: 8   LSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVL 66

Query: 70  QPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127
               F   P +V+L +    I  +    F G   L  L L  N  +R L    F  L +L
Sbjct: 67  AANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DIRVLRAGAFDDLTEL 125

Query: 128 HALYLYKCGLSALP------------------------AGVFGGLHSLQYLYLQDNHIEY 163
             LYL    ++ LP                        AG F G   L++LYL +N +  
Sbjct: 126 TYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSS 185

Query: 164 LQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDL-RR 222
           LQ     D+ NL+   +  N+L S        L  ++ L L  N L+ +   AF    R 
Sbjct: 186 LQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRY 245

Query: 223 LTTLFLFNNSLSELQGECLA----------------------PLGALEFLRLNGNPWDCG 260
           L TL+L N +L +                             P  +LE L L  NPW C 
Sbjct: 246 LETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNNPWKCT 305

Query: 261 CRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGP 307
           C+ R L  WL+  + S     C SP    GQ ++    + FR+C  P
Sbjct: 306 CQLRGLRRWLEA-KASRPDATCASPAKFKGQHIR--DTDAFRSCKFP 349


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 78/240 (32%), Positives = 110/240 (45%), Gaps = 7/240 (2%)

Query: 22  GGGCPRDCVCY----PAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFS-- 75
           G  CP  CVC        ++V C + N   +P+G+P  ++ ++L  N +  + P  F   
Sbjct: 76  GPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL 135

Query: 76  PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKC 135
            ++  L +    +  + P    G  +L  L L  N QLR+LA  TF     L +L L   
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNN 194

Query: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG 195
            LS L  G+F GL SL  L L  N +  L D  F  L +L  L L GN+L  L P  F G
Sbjct: 195 RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG 254

Query: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
           L  L  L L  N L+ +    F  L RL  L+L  N ++ +       L AL +L L+ N
Sbjct: 255 LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 314



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 83/279 (29%), Positives = 125/279 (44%), Gaps = 27/279 (9%)

Query: 57  ERVFLQNNRIGLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLR 114
           E + L +NRI  L    F     +  L +  N +  +    F G  ++  ++L  N  LR
Sbjct: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 413

Query: 115 TLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVN 174
            L  + F+GL KLH+L+L    L  +    F GL  L+ L+L+DN +  +++     L  
Sbjct: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473

Query: 175 LSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS 234
           L  L L  N+L  L    F+GL  L+ LLL  N+L  +   A   L+R   L + +N L 
Sbjct: 474 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 533

Query: 235 ELQGECLAPLGALEFLR--------------------LNGNPWDCGCRARSLWEWLQRFR 274
            L    LAPLG L +L                     L GNPWDCGC  ++L ++  +  
Sbjct: 534 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQ-- 591

Query: 275 GSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQI 313
            + SAVP     +  G D +   A  + N T  + P  +
Sbjct: 592 -NPSAVPRFVQAICEGDDCQ-PPAYTYNNITCASPPEVV 628



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 59/175 (33%), Positives = 91/175 (52%), Gaps = 1/175 (0%)

Query: 81  LWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSAL 140
           L +  N + Y+ P+ F G   L ELDL  N  LR +    F  L +L  LYL +  ++A+
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVFVQLPRLQKLYLDRNLIAAV 295

Query: 141 PAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLD 200
             G F GL +L++L L  N +  L +D F  L+ L  L L  N + SL P TF+ L  L+
Sbjct: 296 APGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 355

Query: 201 RLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
            L L  N+++ +  ++F  L +L  L L +N L E++      L  +  + L+GN
Sbjct: 356 ELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 69/233 (29%), Positives = 95/233 (40%), Gaps = 28/233 (12%)

Query: 61  LQNNRIGLLQPGHFS--------------------------PAMVTLWIYSNNITYIHPS 94
           L  NR+  LQP  FS                          P +  L++  N I  + P 
Sbjct: 239 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 298

Query: 95  TFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYL 154
            F G   L  LDL  NR +  L  +TF GL+ L  L L    +++L    F  LH L+ L
Sbjct: 299 AFLGLKALRWLDLSHNR-VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEEL 357

Query: 155 YLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHH 214
            L  N I  L +  F  L  L  L L  N+L  +  G F GL N+  + L  N L+ +  
Sbjct: 358 QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE 417

Query: 215 KAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLW 267
           + F  L +L +L L  + L  ++      L  L  L L  N    G   +SLW
Sbjct: 418 QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLW 469


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 78/240 (32%), Positives = 110/240 (45%), Gaps = 7/240 (2%)

Query: 22  GGGCPRDCVCY----PAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFS-- 75
           G  CP  CVC        ++V C + N   +P+G+P  ++ ++L  N +  + P  F   
Sbjct: 38  GPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL 97

Query: 76  PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKC 135
            ++  L +    +  + P    G  +L  L L  N QLR+LA  TF     L +L L   
Sbjct: 98  SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNN 156

Query: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG 195
            LS L  G+F GL SL  L L  N +  L D  F  L +L  L L GN+L  L P  F G
Sbjct: 157 RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG 216

Query: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
           L  L  L L  N L+ +    F  L RL  L+L  N ++ +       L AL +L L+ N
Sbjct: 217 LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 276



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 83/279 (29%), Positives = 125/279 (44%), Gaps = 27/279 (9%)

Query: 57  ERVFLQNNRIGLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLR 114
           E + L +NRI  L    F     +  L +  N +  +    F G  ++  ++L  N  LR
Sbjct: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 375

Query: 115 TLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVN 174
            L  + F+GL KLH+L+L    L  +    F GL  L+ L+L+DN +  +++     L  
Sbjct: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435

Query: 175 LSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS 234
           L  L L  N+L  L    F+GL  L+ LLL  N+L  +   A   L+R   L + +N L 
Sbjct: 436 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 495

Query: 235 ELQGECLAPLGALEFLR--------------------LNGNPWDCGCRARSLWEWLQRFR 274
            L    LAPLG L +L                     L GNPWDCGC  ++L ++  +  
Sbjct: 496 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQ-- 553

Query: 275 GSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQI 313
            + SAVP     +  G D +   A  + N T  + P  +
Sbjct: 554 -NPSAVPRFVQAICEGDDCQ-PPAYTYNNITCASPPEVV 590



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 59/175 (33%), Positives = 91/175 (52%), Gaps = 1/175 (0%)

Query: 81  LWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSAL 140
           L +  N + Y+ P+ F G   L ELDL  N  LR +    F  L +L  LYL +  ++A+
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVFVQLPRLQKLYLDRNLIAAV 257

Query: 141 PAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLD 200
             G F GL +L++L L  N +  L +D F  L+ L  L L  N + SL P TF+ L  L+
Sbjct: 258 APGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 317

Query: 201 RLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
            L L  N+++ +  ++F  L +L  L L +N L E++      L  +  + L+GN
Sbjct: 318 ELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 69/233 (29%), Positives = 95/233 (40%), Gaps = 28/233 (12%)

Query: 61  LQNNRIGLLQPGHFS--------------------------PAMVTLWIYSNNITYIHPS 94
           L  NR+  LQP  FS                          P +  L++  N I  + P 
Sbjct: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 260

Query: 95  TFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYL 154
            F G   L  LDL  NR +  L  +TF GL+ L  L L    +++L    F  LH L+ L
Sbjct: 261 AFLGLKALRWLDLSHNR-VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEEL 319

Query: 155 YLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHH 214
            L  N I  L +  F  L  L  L L  N+L  +  G F GL N+  + L  N L+ +  
Sbjct: 320 QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE 379

Query: 215 KAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLW 267
           + F  L +L +L L  + L  ++      L  L  L L  N    G   +SLW
Sbjct: 380 QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLW 431


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 81/243 (33%), Positives = 101/243 (41%), Gaps = 23/243 (9%)

Query: 11  LLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQ 70
           LL L+      GG CP  C C   P  V C      A+P G+P+D+E + L  NR+  LQ
Sbjct: 17  LLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQ 76

Query: 71  PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHAL 130
            G  S   +                      L+ELDL  N QL TL P  F GL  L  L
Sbjct: 77  QGMLSRLSL----------------------LQELDLSYN-QLSTLEPGAFHGLQSLLTL 113

Query: 131 YLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGP 190
            L    L  +  GVF GL +L  L L+ N I    D  F +L +L  L +  N L  + P
Sbjct: 114 RLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAP 173

Query: 191 GTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFL 250
           G F GL  L  L L    L  V   A   L  L  L L    +  L    L  LG L+ L
Sbjct: 174 GAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKEL 233

Query: 251 RLN 253
            ++
Sbjct: 234 EIH 236



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 42/122 (34%), Positives = 55/122 (45%), Gaps = 2/122 (1%)

Query: 135 CGLSALPAGVFGGLH-SLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTF 193
           CG   L A V GGL    + L L  N +  LQ  +   L  L  L L  N+L +L PG F
Sbjct: 46  CGHRQLEA-VPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAF 104

Query: 194 RGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLN 253
            GL +L  L L  N+L+ +    F  L  LT L L  N +          LG+L+ L + 
Sbjct: 105 HGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVG 164

Query: 254 GN 255
            N
Sbjct: 165 DN 166


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 58/185 (31%), Positives = 98/185 (52%), Gaps = 4/185 (2%)

Query: 122 QGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLH 181
           +G+V++    L +  + A+PAG F     L+ + +  N I  +  D F  L +L+ L L+
Sbjct: 307 EGIVEIR---LEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLY 363

Query: 182 GNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECL 241
           GNK+  +  G F GLV+L  LLL+ N++  +    F DL+ L  L L++N L  +     
Sbjct: 364 GNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLF 423

Query: 242 APLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDF 301
           APL +++ L L  NP+ C C  + L ++LQ     +S   C SP     + +  ++++ F
Sbjct: 424 APLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKF 483

Query: 302 RNCTG 306
           R C+G
Sbjct: 484 R-CSG 487



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 79/301 (26%), Positives = 123/301 (40%), Gaps = 52/301 (17%)

Query: 11  LLLLVAAEL--PLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGL 68
           L L +A+ L  P    CP  C C  A  +V C      A+P GIP ++ER+ L       
Sbjct: 18  LALALASVLSGPPAVACPTKCTCSAA--SVDCHGLGLRAVPRGIPRNAERLDLDR----- 70

Query: 69  LQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLH 128
                            NNIT I    F G  +L  L L DN Q+  +    FQ L +L 
Sbjct: 71  -----------------NNITRITKMDFAGLKNLRVLHLEDN-QVSVIERGAFQDLKQLE 112

Query: 129 ALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSL 188
            L L K  L  LP  +F     L  L L +N I+ +    F  + ++ +L L  N +  +
Sbjct: 113 RLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCI 172

Query: 189 GPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALE 248
             G FR L +L+ L L+ N +  +   +F+ + ++ T                       
Sbjct: 173 EDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRT----------------------- 209

Query: 249 FLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPA 308
            LRL+ N   C C    L +WL++ R       C++P    G ++  ++ +++  C  P 
Sbjct: 210 -LRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEY-VCPAPH 267

Query: 309 S 309
           S
Sbjct: 268 S 268



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 56/183 (30%), Positives = 84/183 (45%), Gaps = 25/183 (13%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP  C C  +   V C+      IP  +P     + L+ N I  +  G F+         
Sbjct: 280 CPSPCTC--SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ-------- 329

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
                         +  L+ +D+  N Q+  +AP+ FQGL  L +L LY   ++ +  G+
Sbjct: 330 --------------YKKLKRIDISKN-QISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLL 204
           F GL SLQ L L  N I  L+ + F DL NL+ L L+ NKL ++  G F  L ++  L L
Sbjct: 375 FDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHL 434

Query: 205 HEN 207
            +N
Sbjct: 435 AQN 437



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 45/164 (27%), Positives = 79/164 (48%), Gaps = 1/164 (0%)

Query: 143 GVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRL 202
           G+F  L +L+ + L +N I+ +++  F    ++  L L GN+L ++    FRGL  L  L
Sbjct: 551 GIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTL 610

Query: 203 LLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCR 262
           +L  N +  V +  F  L  +  L L++N ++ +       L +L  + L  NP++C C 
Sbjct: 611 MLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCH 670

Query: 263 ARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTG 306
              L +WL++ R  S    C  P       ++ +  +DF  C G
Sbjct: 671 LAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDF-TCDG 713



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 54/173 (31%), Positives = 77/173 (44%), Gaps = 7/173 (4%)

Query: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG 195
           GL ALP G+      +  LYL+ NH+  +  ++   L +L+ + L  N +  L   TF  
Sbjct: 742 GLRALPRGM---PKDVTELYLEGNHLTAVPRELSA-LRHLTLIDLSNNSISMLTNYTFSN 797

Query: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
           + +L  L+L  N+L+ +   AF+ LR L  L L  N +S +       L +L  L L  N
Sbjct: 798 MSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857

Query: 256 PWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFR-NCTGP 307
           P  C C  R L EW++          C SP      D  LL     R  C GP
Sbjct: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSP--EPMADRLLLTTPTHRFQCKGP 908



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 46/161 (28%), Positives = 62/161 (38%), Gaps = 26/161 (16%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP  C C      V C      A+P G+P D   ++L+ N +  +               
Sbjct: 725 CPEQCTCMET--VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV--------------- 767

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
                   P       HL  +DL +N  +  L   TF  +  L  L L    L  +P   
Sbjct: 768 --------PRELSALRHLTLIDLSNN-SISMLTNYTFSNMSHLSTLILSYNRLRCIPVHA 818

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKL 185
           F GL SL+ L L  N I  + +  F DL +LSHL L  N L
Sbjct: 819 FNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%)

Query: 80  TLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYL 132
           TL + SN I  +   TF G   +  L L DNR + T+ P  F  LV L  + L
Sbjct: 609 TLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNR-ITTITPGAFTTLVSLSTINL 660


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 82/257 (31%), Positives = 112/257 (43%), Gaps = 9/257 (3%)

Query: 61  LQNNRIGLLQPGHFSPAMVTLWIY--SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLA- 117
           L  N +G L    F+P    L+++  SN I ++  + F     L  L+L  N    +L  
Sbjct: 162 LDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRH 221

Query: 118 PETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSH 177
             TF  L  L +L L    L  L   +F  L  L  L L+ N + +L  + F  L  L  
Sbjct: 222 AATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRE 281

Query: 178 LFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQ 237
           L L GN+L  L       L +L+ L L  N+L  +H   F  L RL  L L NN+LS L 
Sbjct: 282 LRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALS 341

Query: 238 GECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSA----VPCVSPGLRHGQDL 293
           G+  A   AL  L L+GN W C CR R L  W+  +          V C  P    G+ L
Sbjct: 342 GDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYL 401

Query: 294 KLLRAEDFRN--CTGPA 308
             L  +  +N  C  P+
Sbjct: 402 DYLDDQQLQNGSCADPS 418



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 74/233 (31%), Positives = 95/233 (40%), Gaps = 22/233 (9%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP  C C   P  + C       +P+   + S    L                  T  + 
Sbjct: 27  CPERCDCQH-PQHLLCTNRGLRVVPKTSSLPSPHDVL------------------TYSLG 67

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
            N IT I    F     L  LDL  N Q+R+L P+TF+ L +L  LYL    L AL  G 
Sbjct: 68  GNFITNITAFDFHRLGQLRRLDLQYN-QIRSLHPKTFEKLSRLEELYLGNNLLQALAPGT 126

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLL 204
              L  L+ LY   N I  L    F  L +L  L L GN L +L    F  L NL  L L
Sbjct: 127 LAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHL 186

Query: 205 HENQLQWVHHKAFHDLRRLTTLFLFNNSL--SELQGECLAPLGALEFLRLNGN 255
             N+++++   AF  L +L  L L  N L  S       APL +L  L L+ N
Sbjct: 187 ESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 63/183 (34%), Positives = 88/183 (48%), Gaps = 25/183 (13%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP  C C  +   V C+      IP  +P     + L+ N I ++ PG FSP        
Sbjct: 273 CPAACTC--SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSP-------- 322

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
                         +  L  +DL +N Q+  LAP+ FQGL  L++L LY   ++ LP  +
Sbjct: 323 --------------YKKLRRIDLSNN-QISELAPDAFQGLRSLNSLVLYGNKITELPKSL 367

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLL 204
           F GL SLQ L L  N I  L+ D F DL NL+ L L+ NKL ++  GTF  L  +  + L
Sbjct: 368 FEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHL 427

Query: 205 HEN 207
            +N
Sbjct: 428 AQN 430



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 73/285 (25%), Positives = 113/285 (39%), Gaps = 50/285 (17%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP  C C  +  TV C      ++P  IP ++ER+ L  N                    
Sbjct: 28  CPAQCSC--SGSTVDCHGLALRSVPRNIPRNTERLDLNGN-------------------- 65

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
             NIT I  + F G  HL  L L +N+                         +S +  G 
Sbjct: 66  --NITRITKTDFAGLRHLRVLQLMENK-------------------------ISTIERGA 98

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLL 204
           F  L  L+ L L  NH++   + +F+    L  L L  N++ ++    FRG V++  L L
Sbjct: 99  FQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQL 158

Query: 205 HENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRAR 264
             NQ+  +   AF  LR L  L L NN+++ L       +  L   RL+ N   C C   
Sbjct: 159 DYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLA 218

Query: 265 SLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPAS 309
            L +WL++         C+ P    G ++  ++  +F  C+G  S
Sbjct: 219 WLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF-VCSGHQS 262



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%)

Query: 137 LSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGL 196
           +  +P G F     L+ + L +N I  L  D F  L +L+ L L+GNK+  L    F GL
Sbjct: 312 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL 371

Query: 197 VNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNP 256
            +L  LLL+ N++  +   AF DL  L  L L++N L  +     +PL A++ + L  NP
Sbjct: 372 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP 431

Query: 257 WDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFR 302
           + C C  + L ++L      +S   C SP     + +  ++++ FR
Sbjct: 432 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFR 477



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 47/162 (29%), Positives = 69/162 (42%), Gaps = 26/162 (16%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIY 84
           CP +C C      V C       +P+GIP D   ++L  N+  L+               
Sbjct: 727 CPTECTCLDT--VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLV--------------- 769

Query: 85  SNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV 144
                   P     + HL  +DL +NR + TL+ ++F  + +L  L L    L  +P   
Sbjct: 770 --------PKELSNYKHLTLIDLSNNR-ISTLSNQSFSNMTQLLTLILSYNRLRCIPPRT 820

Query: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLW 186
           F GL SL+ L L  N I  + +  F DL  LSHL +  N L+
Sbjct: 821 FDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLY 862



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 47/192 (24%), Positives = 85/192 (44%), Gaps = 7/192 (3%)

Query: 143 GVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRL 202
           G+F  L  L+ +   +N I  +++  F     ++ + L  N+L ++    F+GL +L  L
Sbjct: 552 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611

Query: 203 LLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCR 262
           +L  N++  V + +F  L  +  L L++N ++ +       L +L  L L  NP++C C 
Sbjct: 612 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY 671

Query: 263 ARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFR-------NCTGPASPHQIKS 315
              L EWL++ R  +    C  P       ++ +  +DF        N   P S    + 
Sbjct: 672 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC 731

Query: 316 HTLTTTDRAARK 327
             L T  R + K
Sbjct: 732 TCLDTVVRCSNK 743



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 53/162 (32%), Positives = 72/162 (44%), Gaps = 6/162 (3%)

Query: 25  CPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQP-GHFS--PAMVTL 81
           CP  C C     TV C       IPE IP  +  + L NN   +L+  G F   P +  +
Sbjct: 506 CPEKCRCEGT--TVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563

Query: 82  WIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALP 141
              +N IT I    FEG   + E+ L  NR L  +  + F+GL  L  L L    ++ + 
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNR-LENVQHKMFKGLESLKTLMLRSNRITCVG 622

Query: 142 AGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGN 183
              F GL S++ L L DN I  +    F  L +LS L L  N
Sbjct: 623 NDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 44/172 (25%), Positives = 74/172 (43%), Gaps = 5/172 (2%)

Query: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG 195
           GL  LP G+      +  LYL  N    +  ++  +  +L+ + L  N++ +L   +F  
Sbjct: 744 GLKVLPKGI---PRDVTELYLDGNQFTLVPKELS-NYKHLTLIDLSNNRISTLSNQSFSN 799

Query: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
           +  L  L+L  N+L+ +  + F  L+ L  L L  N +S +       L AL  L +  N
Sbjct: 800 MTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN 859

Query: 256 PWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGP 307
           P  C C  + L +W++          C  PG    + L    ++ F  C GP
Sbjct: 860 PLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKF-TCQGP 910



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 27/85 (31%), Positives = 42/85 (49%)

Query: 175 LSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLS 234
           ++ + L  N +  + PG F     L R+ L  NQ+  +   AF  LR L +L L+ N ++
Sbjct: 302 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 361

Query: 235 ELQGECLAPLGALEFLRLNGNPWDC 259
           EL       L +L+ L LN N  +C
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINC 386


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,153,390
Number of Sequences: 37866
Number of extensions: 1052276
Number of successful extensions: 4882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 2797
Number of HSP's gapped (non-prelim): 839
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.