Guide to the Human Genome
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Search of human proteins with 27754771

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
         (1060 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]       2107   0.0  
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]       2046   0.0  
gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]        968   0.0  
gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]        967   0.0  
gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]        903   0.0  
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         698   0.0  
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        698   0.0  
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]        663   0.0  
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]        663   0.0  
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...   660   0.0  
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ...   660   0.0  
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]        654   0.0  
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]        654   0.0  
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]        654   0.0  
gi|190194360 protocadherin 20 [Homo sapiens]                          436   e-122
gi|94538350 protocadherin 17 precursor [Homo sapiens]                 353   5e-97
gi|16933557 dachsous 1 precursor [Homo sapiens]                       348   1e-95
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            343   4e-94
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso...   342   8e-94
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs...   342   8e-94
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       340   4e-93
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]       340   4e-93
gi|11036656 protocadherin beta 7 precursor [Homo sapiens]             340   5e-93
gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs...   338   1e-92
gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs...   338   1e-92
gi|9256604 protocadherin beta 11 precursor [Homo sapiens]             338   2e-92
gi|11128035 protocadherin gamma subfamily B, 2 isoform 1 precurs...   334   3e-91
gi|14270493 protocadherin gamma subfamily B, 2 isoform 2 precurs...   334   3e-91
gi|9256606 protocadherin beta 12 precursor [Homo sapiens]             333   7e-91
gi|9256610 protocadherin beta 15 precursor [Homo sapiens]             333   7e-91

>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score = 2107 bits (5460), Expect = 0.0
 Identities = 1060/1060 (100%), Positives = 1060/1060 (100%)

Query: 1    MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60
            MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV
Sbjct: 1    MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60

Query: 61   VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120
            VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL
Sbjct: 61   VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120

Query: 121  RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180
            RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN
Sbjct: 121  RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180

Query: 181  TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240
            TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR
Sbjct: 181  TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240

Query: 241  ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300
            ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI
Sbjct: 241  ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300

Query: 301  QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360
            QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK
Sbjct: 301  QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360

Query: 361  DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420
            DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS
Sbjct: 361  DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420

Query: 421  DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480
            DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD
Sbjct: 421  DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480

Query: 481  SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540
            SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE
Sbjct: 481  SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540

Query: 541  LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600
            LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV
Sbjct: 541  LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600

Query: 601  NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660
            NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI
Sbjct: 601  NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660

Query: 661  QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720
            QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN
Sbjct: 661  QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720

Query: 721  TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780
            TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI
Sbjct: 721  TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780

Query: 781  ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840
            ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG
Sbjct: 781  ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840

Query: 841  DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900
            DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK
Sbjct: 841  DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900

Query: 901  PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960
            PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP
Sbjct: 901  PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960

Query: 961  GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020
            GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY
Sbjct: 961  GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020

Query: 1021 SYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE 1060
            SYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE
Sbjct: 1021 SYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE 1060


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score = 2046 bits (5300), Expect = 0.0
 Identities = 1033/1034 (99%), Positives = 1034/1034 (100%)

Query: 1    MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60
            MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV
Sbjct: 1    MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60

Query: 61   VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120
            VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL
Sbjct: 61   VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120

Query: 121  RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180
            RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN
Sbjct: 121  RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180

Query: 181  TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240
            TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR
Sbjct: 181  TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240

Query: 241  ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300
            ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI
Sbjct: 241  ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300

Query: 301  QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360
            QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK
Sbjct: 301  QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360

Query: 361  DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420
            DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS
Sbjct: 361  DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420

Query: 421  DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480
            DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD
Sbjct: 421  DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480

Query: 481  SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540
            SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE
Sbjct: 481  SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540

Query: 541  LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600
            LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV
Sbjct: 541  LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600

Query: 601  NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660
            NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI
Sbjct: 601  NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660

Query: 661  QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720
            QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN
Sbjct: 661  QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720

Query: 721  TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780
            TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI
Sbjct: 721  TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780

Query: 781  ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840
            ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG
Sbjct: 781  ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840

Query: 841  DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900
            DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK
Sbjct: 841  DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900

Query: 901  PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960
            PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP
Sbjct: 901  PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960

Query: 961  GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020
            GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY
Sbjct: 961  GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020

Query: 1021 SYRTNPPKYPSKQV 1034
            SYRTNPPKYPSKQ+
Sbjct: 1021 SYRTNPPKYPSKQL 1034


>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
          Length = 1072

 Score =  968 bits (2503), Expect = 0.0
 Identities = 524/1048 (50%), Positives = 706/1048 (67%), Gaps = 66/1048 (6%)

Query: 46   LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102
            LLL L+ S   A +++ Y++ EE P +  IG++A+D G     G + + LE G+ YL++D
Sbjct: 19   LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78

Query: 103  GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162
              TG++ T+E  IDRE L +CQ     + C L+FEVS+    Q+    L EGQ+ V DIN
Sbjct: 79   NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137

Query: 163  DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP----------- 211
            DNTP F SPV+TL + EN  +G+L+ +P A+DRD G NG+  YEL   P           
Sbjct: 138  DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197

Query: 212  -----------------------------EAQE------------LFGLQVAEDQE-EKQ 229
                                         +A E            +F LQVA+  + EKQ
Sbjct: 198  AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257

Query: 230  PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAEL 289
            PQLIV G LDRE+ DSY+LT++V+DGG PPR+S A+LRV + D NDN+P+FE+  YEA+L
Sbjct: 258  PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317

Query: 290  SENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED 349
            +ENS  G  ++Q++A D D G N +IEY F  A E VRRLLRLD  +G ++V   +DRE+
Sbjct: 318  AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377

Query: 350  LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409
            ++ LRF+V+A+DRG  PK+ +A VV+ +KD NDN P+IEIR IG +  +DG+AN++EDV 
Sbjct: 378  VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437

Query: 410  EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GSDSKKKYFLQTTTPLDYEK 468
             +T +ALVQVSDRD+GEN  VTC V GDVPFQL+ AS+T G  +KKKYFL T+TPLDYE 
Sbjct: 438  VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497

Query: 469  VKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEI 528
             +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV EV FPENN PGE +A +
Sbjct: 498  TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557

Query: 529  TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588
             A+DADSG NAE+ YSL+   +  G+F I P++G+I V T LDREQ + YE KV A D+G
Sbjct: 558  LATDADSGKNAEIAYSLDS--SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615

Query: 589  SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648
             P LQG+ TV+V V D NDNDPKFM   + F V EN+   SPVGMVTV+D DKG NA++ 
Sbjct: 616  IPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMS 675

Query: 649  LSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708
            L +E++N  F I+N TGTI S++SFDRE Q+TYTF++KAVDGG PPRSA   V++ V+DE
Sbjct: 676  LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDE 735

Query: 709  NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIG 768
            NDNAP +T P N S+ LL P + +   V+ V A D D G+NA+L YSI GGNP+ LF+I 
Sbjct: 736  NDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEID 795

Query: 769  SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGH 828
              SG ++L  ++ ++H+GLHRLVV+V+D G+P +  T LVH++VNE+++N T +++ +  
Sbjct: 796  PTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855

Query: 829  SLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQA 888
            SL  PL  DIAGDP YE SKQR +I+ GVVAG++ V L+I + V+ RYCR +  K+GY+A
Sbjct: 856  SLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKN-KNGYEA 914

Query: 889  GKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGD 948
            GKK+ +D + P+   K+ K  K K K  KS +P+       EA      +++ +++   D
Sbjct: 915  GKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSD 973

Query: 949  SPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGT 1006
            SP +  +  +N  PGSPDL RHY+S+SPLP++QL PQSP+A KKHQ VQDLPPANTFVG 
Sbjct: 974  SPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033

Query: 1007 GDTTSTGSEQYSDYSYRTNPPKYPSKQV 1034
            GD  S GS+  S+YS +TN  KY SKQV
Sbjct: 1034 GDNISIGSDHCSEYSCQTN-NKY-SKQV 1059


>gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]
          Length = 1069

 Score =  967 bits (2500), Expect = 0.0
 Identities = 523/1048 (49%), Positives = 706/1048 (67%), Gaps = 66/1048 (6%)

Query: 46   LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102
            LLL L+ S   A +++ Y++ EE P +  IG++A+D G     G + + LE G+ YL++D
Sbjct: 19   LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78

Query: 103  GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162
              TG++ T+E  IDRE L +CQ     + C L+FEVS+    Q+    L EGQ+ V DIN
Sbjct: 79   NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137

Query: 163  DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP----------- 211
            DNTP F SPV+TL + EN  +G+L+ +P A+DRD G NG+  YEL   P           
Sbjct: 138  DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197

Query: 212  -----------------------------EAQE------------LFGLQVAEDQE-EKQ 229
                                         +A E            +F LQVA+  + EKQ
Sbjct: 198  AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257

Query: 230  PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAEL 289
            PQLIV G LDRE+ DSY+LT++V+DGG PPR+S A+LRV + D NDN+P+FE+  YEA+L
Sbjct: 258  PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317

Query: 290  SENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED 349
            +ENS  G  ++Q++A D D G N +IEY F  A E VRRLLRLD  +G ++V   +DRE+
Sbjct: 318  AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377

Query: 350  LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409
            ++ LRF+V+A+DRG  PK+ +A VV+ +KD NDN P+IEIR IG +  +DG+AN++EDV 
Sbjct: 378  VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437

Query: 410  EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GSDSKKKYFLQTTTPLDYEK 468
             +T +ALVQVSDRD+GEN  VTC V GDVPFQL+ AS+T G  +KKKYFL T+TPLDYE 
Sbjct: 438  VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497

Query: 469  VKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEI 528
             +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV EV FPENN PGE +A +
Sbjct: 498  TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557

Query: 529  TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588
             A+DADSG NAE+ YSL+   +  G+F I P++G+I V T LDREQ + YE KV A D+G
Sbjct: 558  LATDADSGKNAEIAYSLDS--SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615

Query: 589  SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648
             P LQG+ TV+V V D NDNDPKFM   + F V EN+   SPVGMVTV+D DKG NA++ 
Sbjct: 616  IPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMS 675

Query: 649  LSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708
            L +E++N  F I+N TGTI S++SFDRE Q+TYTF++KAVDGG PPRSA   V++ V+DE
Sbjct: 676  LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDE 735

Query: 709  NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIG 768
            NDNAP +T P N S+ LL P + +   V+ V A D D G+NA+L YSI GGNP+ LF+I 
Sbjct: 736  NDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEID 795

Query: 769  SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGH 828
              SG ++L  ++ ++H+GLHRLVV+V+D G+P +  T LVH++VNE+++N T +++ +  
Sbjct: 796  PTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855

Query: 829  SLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQA 888
            SL  PL  DIAGDP YE SKQR +I+ GVVAG++ V L+I + V+ RYCR +  K+GY+A
Sbjct: 856  SLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKN-KNGYEA 914

Query: 889  GKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGD 948
            GKK+ +D + P+   K+ K  K K K  KS +P+       EA      +++ +++   D
Sbjct: 915  GKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSD 973

Query: 949  SPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGT 1006
            SP +  +  +N  PGSPDL RHY+S+SPLP++QL PQSP+A KKHQ VQDLPPANTFVG 
Sbjct: 974  SPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033

Query: 1007 GDTTSTGSEQYSDYSYRTNPPKYPSKQV 1034
            GD  S GS+  S+YS +TN  KY SKQ+
Sbjct: 1034 GDNISIGSDHCSEYSCQTN-NKY-SKQM 1059


>gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]
          Length = 1200

 Score =  903 bits (2333), Expect = 0.0
 Identities = 494/1021 (48%), Positives = 674/1021 (66%), Gaps = 32/1021 (3%)

Query: 46   LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102
            LLL L+ S   A +++ Y++ EE P +  IG++A+D G     G + + LE G+ YL++D
Sbjct: 19   LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78

Query: 103  GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162
              TG++ T+E  IDRE L +CQ     + C L+FEVS+    Q+    L EGQ+ V DIN
Sbjct: 79   NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137

Query: 163  DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVA 222
            DNTP F SPV+TL + EN  +G+L+ +P A+DRD G NG+  YEL   P      G    
Sbjct: 138  DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197

Query: 223  EDQEEKQPQLIVMGN--------LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
                +  P     GN          + R D+ +       GG+ P   S++  + V DT 
Sbjct: 198  AGAADSAPYPGGGGNGASGGGSGGSKRRLDASE-----GGGGTNPGGRSSVFELQVADTP 252

Query: 275  DNAPK---FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLR 331
            D   +     +  YEA+L+ENS  G  ++Q++A D D G N +IEY F  A E VRRLLR
Sbjct: 253  DGEKQPQLIVKGVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLR 312

Query: 332  LDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
            LD  +G ++V   +DRE+++ LRF+V+A+DRG  PK+ +A VV+ +KD NDN P+IEIR 
Sbjct: 313  LDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRK 372

Query: 392  IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GS 450
            IG +  +DG+AN++EDV  +T +ALVQVSDRD+GEN  VTC V GDVPFQL+ AS+T G 
Sbjct: 373  IGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGD 432

Query: 451  DSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV 510
             +KKKYFL T+TPLDYE  +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV
Sbjct: 433  QNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSV 492

Query: 511  TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570
             EV FPENN PGE +A + A+DADSG NAE+ YSL  + +  G+F I P++G+I V T L
Sbjct: 493  VEVYFPENNIPGERVATVLATDADSGKNAEIAYSL--DSSVMGIFAIDPDSGDILVNTVL 550

Query: 571  DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630
            DREQ + YE KV A D+G P LQG+ TV+V V D NDNDPKFM   + F V EN+   SP
Sbjct: 551  DREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSP 610

Query: 631  VGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDG 690
            VGMVTV+D DKG NA++ L +E++N  F I+N TGTI S++SFDRE Q+TYTF++KAVDG
Sbjct: 611  VGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDG 670

Query: 691  GVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNA 750
            G PPRSA   V++ V+DENDNAP +T P N S+ LL P + +   V+ V A D D G+NA
Sbjct: 671  GDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINA 730

Query: 751  ELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHL 810
            +L YSI GGNP+ LF+I   SG ++L  ++ ++H+GLHRLVV+V+D G+P +  T LVH+
Sbjct: 731  DLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 790

Query: 811  YVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIAL 870
            +VNE+++N T +++ +  SL  PL  DIAGDP YE SKQR +I+ GVVAG++ V L+I +
Sbjct: 791  FVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILI 850

Query: 871  AVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDE 930
             V+ RYCR +  K+GY+AGKK+ +D + P+   K+ K  K K K  KS +P+       E
Sbjct: 851  VVMARYCRSKN-KNGYEAGKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVE 908

Query: 931  AGLQKSLKFNLMSDAPGDSPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSAS 988
            A      +++ +++   DSP +  +  +N  PGSPDL RHY+S+SPLP++QL PQSP+A 
Sbjct: 909  ASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAG 968

Query: 989  KKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQVGQPFQLSTPQPLPH 1048
            KKHQ VQDLPPANTFVG GD  S GS+  S+YS +TN     +K   QPF+  T   +  
Sbjct: 969  KKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTN-----NKYSKQPFRRVTFSVVSQ 1023

Query: 1049 P 1049
            P
Sbjct: 1024 P 1024


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  698 bits (1801), Expect = 0.0
 Identities = 420/1006 (41%), Positives = 589/1006 (58%), Gaps = 50/1006 (4%)

Query: 42   MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH--------LYKL- 92
            +L AL+  L      A  ++Y + EE P N  IG++  D     +          +Y+L 
Sbjct: 8    LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67

Query: 93   -EVG-APYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR 150
             + G AP ++V   TG+IFTT   IDRE L    +    + C  E EV I   + N   R
Sbjct: 68   SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI---LPNDFFR 124

Query: 151  LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG 210
            L++ +I V+D NDN P F SPVI ++IPENT I S FPIP A+D D G NGV  YEL  G
Sbjct: 125  LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184

Query: 211  PEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269
               Q +FGL + E  E EK PQLIV  NLDRE+ D+Y + IKV+DGG+P ++S+A+L+VT
Sbjct: 185  ---QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241

Query: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH-QAPEVVRR 328
            V D NDN P F+    E  + EN+P+G SVIQ+ A D+D G+NAEI Y F  Q     +R
Sbjct: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 329  LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388
            L  L+  TGLITVQ  +DRE+ +  + +VLA D  + P  ARA V + V D+NDN P I+
Sbjct: 302  LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNID 359

Query: 389  IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448
            +R I  ++  +G   +SE     T +AL+ VSD+D   N  V C +  +VPF L+   + 
Sbjct: 360  LRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417

Query: 449  GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
                  +Y L+T++ LDYE  K+++ +IVA DSG P L+ T  ++V++ D NDN P+F Q
Sbjct: 418  ------QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471

Query: 509  SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKT 568
             V E++  ENN+ G  +  I+A+D DSG NA++VY L P  +    F +  +TG +    
Sbjct: 472  PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---FFDLDRKTGVLTASR 528

Query: 569  SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628
              DRE++E +   V A D G+P LQ  A V+V VLD NDN PKF  + + F V EN+P  
Sbjct: 529  VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588

Query: 629  SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688
            S VG++TV D D GEN  V LS+  DN +FV+   +G I S++SFDREQQS+YTF +KA 
Sbjct: 589  STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648

Query: 689  DGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747
            DGG PPRS+   VTINV+D NDN+P  I+ PSNTS KL+      G  V++V A D D+G
Sbjct: 649  DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708

Query: 748  VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGT-A 806
            +NAEL Y+I  GN  GLF+I   +G ITLE++      GLHRLVV +SD G P    T  
Sbjct: 709  MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768

Query: 807  LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866
            LV LYVN+T  N + +  L+  +++TPLD +I    +  +++    I+  ++AG + V +
Sbjct: 769  LVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIV 828

Query: 867  LIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKP----- 921
            +I + VLVR CR     S ++A ++  +      P+ +  +  K K KK KSPK      
Sbjct: 829  VIFVTVLVR-CRH---ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNF 884

Query: 922  VKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHL-------PLNYPPGSPDLGRHYRSNSP 974
            V   E + +  + + +   +   A  +   I         P  + P SPDL +HY+S SP
Sbjct: 885  VTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASP 944

Query: 975  LPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020
             P+  L+P +P + KKH V+Q+LP  NTFVG  DT S  S   SD+
Sbjct: 945  QPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDH 990


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  698 bits (1801), Expect = 0.0
 Identities = 420/1006 (41%), Positives = 589/1006 (58%), Gaps = 50/1006 (4%)

Query: 42   MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH--------LYKL- 92
            +L AL+  L      A  ++Y + EE P N  IG++  D     +          +Y+L 
Sbjct: 8    LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67

Query: 93   -EVG-APYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR 150
             + G AP ++V   TG+IFTT   IDRE L    +    + C  E EV I   + N   R
Sbjct: 68   SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI---LPNDFFR 124

Query: 151  LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG 210
            L++ +I V+D NDN P F SPVI ++IPENT I S FPIP A+D D G NGV  YEL  G
Sbjct: 125  LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184

Query: 211  PEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269
               Q +FGL + E  E EK PQLIV  NLDRE+ D+Y + IKV+DGG+P ++S+A+L+VT
Sbjct: 185  ---QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241

Query: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH-QAPEVVRR 328
            V D NDN P F+    E  + EN+P+G SVIQ+ A D+D G+NAEI Y F  Q     +R
Sbjct: 242  VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301

Query: 329  LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388
            L  L+  TGLITVQ  +DRE+ +  + +VLA D  + P  ARA V + V D+NDN P I+
Sbjct: 302  LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNID 359

Query: 389  IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448
            +R I  ++  +G   +SE     T +AL+ VSD+D   N  V C +  +VPF L+   + 
Sbjct: 360  LRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417

Query: 449  GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
                  +Y L+T++ LDYE  K+++ +IVA DSG P L+ T  ++V++ D NDN P+F Q
Sbjct: 418  ------QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471

Query: 509  SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKT 568
             V E++  ENN+ G  +  I+A+D DSG NA++VY L P  +    F +  +TG +    
Sbjct: 472  PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---FFDLDRKTGVLTASR 528

Query: 569  SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628
              DRE++E +   V A D G+P LQ  A V+V VLD NDN PKF  + + F V EN+P  
Sbjct: 529  VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588

Query: 629  SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688
            S VG++TV D D GEN  V LS+  DN +FV+   +G I S++SFDREQQS+YTF +KA 
Sbjct: 589  STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648

Query: 689  DGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747
            DGG PPRS+   VTINV+D NDN+P  I+ PSNTS KL+      G  V++V A D D+G
Sbjct: 649  DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708

Query: 748  VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGT-A 806
            +NAEL Y+I  GN  GLF+I   +G ITLE++      GLHRLVV +SD G P    T  
Sbjct: 709  MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768

Query: 807  LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866
            LV LYVN+T  N + +  L+  +++TPLD +I    +  +++    I+  ++AG + V +
Sbjct: 769  LVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIV 828

Query: 867  LIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKP----- 921
            +I + VLVR CR     S ++A ++  +      P+ +  +  K K KK KSPK      
Sbjct: 829  VIFVTVLVR-CRH---ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNF 884

Query: 922  VKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHL-------PLNYPPGSPDLGRHYRSNSP 974
            V   E + +  + + +   +   A  +   I         P  + P SPDL +HY+S SP
Sbjct: 885  VTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASP 944

Query: 975  LPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020
             P+  L+P +P + KKH V+Q+LP  NTFVG  DT S  S   SD+
Sbjct: 945  QPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDH 990


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score =  663 bits (1710), Expect = 0.0
 Identities = 412/1056 (39%), Positives = 586/1056 (55%), Gaps = 59/1056 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL        A    Y + EE P N LIG L  D     + +        
Sbjct: 3    LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 63   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 117  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 177  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 234  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 352  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+T   LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 410  PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A DADSG NA++ Y L P+   +  F++   TG 
Sbjct: 464  PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + YNF V E
Sbjct: 522  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 582  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  PSN S++L+ P T  G  V QV A 
Sbjct: 642  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 702  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S + P+  +         +     IL   VAG 
Sbjct: 762  LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q   K+  +   P P  +     K K KK K SPK
Sbjct: 822  ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879

Query: 921  PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
             +            +D D  G  +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 880  NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKY 1029
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV   D+ S  S   SD  Y  +   Y
Sbjct: 940  KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVAC-DSISKCSSSSSD-PYSVSDCGY 996

Query: 1030 PSKQVGQPFQLSTPQPLPH------PYHGAIWTEVW 1059
            P      P  + T  P+        P   +   E+W
Sbjct: 997  PVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTMEIW 1032


>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
          Length = 1347

 Score =  663 bits (1710), Expect = 0.0
 Identities = 412/1056 (39%), Positives = 586/1056 (55%), Gaps = 59/1056 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL        A    Y + EE P N LIG L  D     + +        
Sbjct: 3    LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 63   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 117  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 177  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 234  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 352  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+T   LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 410  PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A DADSG NA++ Y L P+   +  F++   TG 
Sbjct: 464  PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + YNF V E
Sbjct: 522  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 582  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  PSN S++L+ P T  G  V QV A 
Sbjct: 642  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 702  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S + P+  +         +     IL   VAG 
Sbjct: 762  LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q   K+  +   P P  +     K K KK K SPK
Sbjct: 822  ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879

Query: 921  PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
             +            +D D  G  +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 880  NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKY 1029
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV   D+ S  S   SD  Y  +   Y
Sbjct: 940  KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVAC-DSISKCSSSSSD-PYSVSDCGY 996

Query: 1030 PSKQVGQPFQLSTPQPLPH------PYHGAIWTEVW 1059
            P      P  + T  P+        P   +   E+W
Sbjct: 997  PVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTMEIW 1032


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
            sapiens]
          Length = 1021

 Score =  660 bits (1703), Expect = 0.0
 Identities = 401/1012 (39%), Positives = 570/1012 (56%), Gaps = 51/1012 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL        A    Y + EE P N LIG L  D     + +        
Sbjct: 3    LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 63   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 117  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 177  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 234  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 352  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+T   LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 410  PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A DADSG NA++ Y L P+   +  F++   TG 
Sbjct: 464  PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + YNF V E
Sbjct: 522  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 582  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  PSN S++L+ P T  G  V QV A 
Sbjct: 642  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 702  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S + P+  +         +     IL   VAG 
Sbjct: 762  LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q   K+  +   P P  +     K K KK K SPK
Sbjct: 822  ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879

Query: 921  PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
             +            +D D  G  +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 880  NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV     +   S     YS
Sbjct: 940  KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVACDSISKCSSSSSDPYS 990


>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
            sapiens]
          Length = 1025

 Score =  660 bits (1703), Expect = 0.0
 Identities = 401/1012 (39%), Positives = 570/1012 (56%), Gaps = 51/1012 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL        A    Y + EE P N LIG L  D     + +        
Sbjct: 3    LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 63   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 117  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 177  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 234  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 352  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+T   LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 410  PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A DADSG NA++ Y L P+   +  F++   TG 
Sbjct: 464  PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + YNF V E
Sbjct: 522  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 582  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  PSN S++L+ P T  G  V QV A 
Sbjct: 642  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 702  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S + P+  +         +     IL   VAG 
Sbjct: 762  LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q   K+  +   P P  +     K K KK K SPK
Sbjct: 822  ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879

Query: 921  PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
             +            +D D  G  +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 880  NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV     +   S     YS
Sbjct: 940  KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVACDSISKCSSSSSDPYS 990


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score =  654 bits (1687), Expect = 0.0
 Identities = 399/1012 (39%), Positives = 571/1012 (56%), Gaps = 51/1012 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL+       A    Y + EE P N LIG+L  D     + +        
Sbjct: 35   LLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQ 94

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 95   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 148

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 149  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 208

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 209  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 265

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 266  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 326  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 383

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 384  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 441

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+    LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 442  PVFSN------QFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A+DADSG NAE+ Y L P+   +  F++   TG 
Sbjct: 496  PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGM 553

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + Y F V E
Sbjct: 554  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 614  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 673

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  P N S++L+ P T  G  V QV A 
Sbjct: 674  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 734  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 793

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S++ P+  +         +     IL   VAG 
Sbjct: 794  LFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 853

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q    +  +   P P  +     K K KK K SPK
Sbjct: 854  ITVVVVIFITAVVR-CRQAPHLKAAQK-NMQNSEWATPNPENRQMIMMKKKKKKKKHSPK 911

Query: 921  ----PVKPVE-------DEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
                 V  +E       D D   +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 912  NLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 971

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV     ++  S     YS
Sbjct: 972  KSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFVACDSISNCSSSSSDPYS 1022


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score =  654 bits (1687), Expect = 0.0
 Identities = 399/1012 (39%), Positives = 571/1012 (56%), Gaps = 51/1012 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL+       A    Y + EE P N LIG+L  D     + +        
Sbjct: 35   LLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQ 94

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 95   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 148

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 149  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 208

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 209  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 265

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 266  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 326  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 383

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 384  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 441

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+    LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 442  PVFSN------QFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A+DADSG NAE+ Y L P+   +  F++   TG 
Sbjct: 496  PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGM 553

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + Y F V E
Sbjct: 554  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 614  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 673

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  P N S++L+ P T  G  V QV A 
Sbjct: 674  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 734  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 793

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S++ P+  +         +     IL   VAG 
Sbjct: 794  LFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 853

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q    +  +   P P  +     K K KK K SPK
Sbjct: 854  ITVVVVIFITAVVR-CRQAPHLKAAQK-NMQNSEWATPNPENRQMIMMKKKKKKKKHSPK 911

Query: 921  ----PVKPVE-------DEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
                 V  +E       D D   +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 912  NLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 971

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV     ++  S     YS
Sbjct: 972  KSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFVACDSISNCSSSSSDPYS 1022


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score =  654 bits (1687), Expect = 0.0
 Identities = 399/1012 (39%), Positives = 571/1012 (56%), Gaps = 51/1012 (5%)

Query: 37   LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88
            LL  + + A+LL+       A    Y + EE P N LIG+L  D     + +        
Sbjct: 24   LLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQ 83

Query: 89   ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
               +YK     P +R++  TG+IFTT   IDRE L  C      + C  E EV+I   + 
Sbjct: 84   FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 137

Query: 146  NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
            +   RL++ +  ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y
Sbjct: 138  DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 197

Query: 206  ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
            EL    ++Q +FGL V E  E +K PQLIV   LDRE  D+Y + +KV+DGG P R+S+A
Sbjct: 198  ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 254

Query: 265  LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323
            +L+V+V DTNDN P F+    E  + EN+P+G SV Q+ A D+D G NA+I ++F     
Sbjct: 255  ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 314

Query: 324  EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
             + RRL  L+  TGLIT++ P+DRE+    +  VLA D G  P  ARA V+V V D+NDN
Sbjct: 315  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 372

Query: 384  APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
             P+I+IR I  V   +    +SE++   T +AL+ V+D+D   N  VTC    ++PF+LR
Sbjct: 373  VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 430

Query: 444  QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                       ++ L+    LDYE  K+Y I+++A D+G PPL+ +  L ++V D NDNA
Sbjct: 431  PVFSN------QFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            PVFTQS   V+ PENN PG  + +++A+DADSG NAE+ Y L P+   +  F++   TG 
Sbjct: 485  PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGM 542

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            + V   LDRE+ + Y   ++A D G P L    TV V+++D NDN P F  + Y F V E
Sbjct: 543  LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 602

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            N+P    VG++TV D D G+N+ V LS+  +N DF I + TG I  ++SFDRE+Q +YTF
Sbjct: 603  NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 662

Query: 684  QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742
             +KA DGG   RS+   VTINV+D NDN P +I  P N S++L+ P T  G  V QV A 
Sbjct: 663  YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 722

Query: 743  DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802
            D D+G+NAE+ YSI GGN   LF I   +G ITL ++ +    GLHR++VK +D G+P  
Sbjct: 723  DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 782

Query: 803  -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861
             +   +V+L+VNE++ N TL+  L+  S++ P+  +         +     IL   VAG 
Sbjct: 783  LFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 842

Query: 862  VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920
            + V ++I +  +VR CRQ       Q    +  +   P P  +     K K KK K SPK
Sbjct: 843  ITVVVVIFITAVVR-CRQAPHLKAAQK-NMQNSEWATPNPENRQMIMMKKKKKKKKHSPK 900

Query: 921  ----PVKPVE-------DEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969
                 V  +E       D D   +   L  +L     G    +  P  + P SPDL RHY
Sbjct: 901  NLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 960

Query: 970  RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021
            +S SP P+ Q+QP++P  + KH ++Q+LP  NTFV     ++  S     YS
Sbjct: 961  KSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFVACDSISNCSSSSSDPYS 1011


>gi|190194360 protocadherin 20 [Homo sapiens]
          Length = 951

 Score =  436 bits (1120), Expect = e-122
 Identities = 300/854 (35%), Positives = 438/854 (51%), Gaps = 68/854 (7%)

Query: 21  PRMEHLR-HSPGPGGQRLLLPSMLLALLLL----LAPSPGHATRVVYKVPEEQPPNTLIG 75
           PR++  R H P        LP + L  L +       S   AT ++Y + E  P   LIG
Sbjct: 24  PRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIG 83

Query: 76  SLAADY-------GFPDVGHLYKLEVGAP-----------------YLRVDGKTGDIFTT 111
           SLA D        G PD         GA                  Y+ +D ++G++ T+
Sbjct: 84  SLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTS 143

Query: 112 ETSIDREGL------------RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159
              IDRE L                +  P D C+L  +V +   +     R ++ +I ++
Sbjct: 144 AQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLV---LPQEYFRFVKVKIAIR 200

Query: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFG 218
           DINDN P F    I++ +PEN  + +   I   A D D G NGV +Y L    +   +F 
Sbjct: 201 DINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL---DYHGMFT 257

Query: 219 LQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNA 277
           L V E++  E+ P LIVMG LDRE  D Y   I  +DGGSPP   SA L + + D NDN 
Sbjct: 258 LDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNC 317

Query: 278 PKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNT 336
           P F        +  N+ +G  +  V+A D D G NA+I Y++ Q  P+  + L  LD NT
Sbjct: 318 PLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENT 377

Query: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396
           G+I +   +    L + + ++LA   G  P    A  +V++  +    P I  R I    
Sbjct: 378 GVIKLFSKIGGSVLESHKLTILANGPGCIPAVITA--LVSIIKVIFRPPEIVPRYIA--N 433

Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
             DG+  + E     T +A   +  RD      V C + G+ PF+L       ++    Y
Sbjct: 434 EIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRLSPYKPYNNE----Y 487

Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516
            L+TT P+DYE  + Y + +VA +S    +     +KVQ++D NDNAP+F Q + E+   
Sbjct: 488 LLETTKPMDYELQQFYEVAVVAWNSEGFHVKRV--IKVQLLDDNDNAPIFLQPLIELTIE 545

Query: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576
           ENN P   + ++ A+DADS    ++ Y L P+  A   F++   TG + V T LDRE++E
Sbjct: 546 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 603

Query: 577 SYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTV 636
            Y   V A D G P  +  ATV + VLD NDN P+F+   ++F V EN P    +G+++V
Sbjct: 604 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 663

Query: 637 IDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRS 696
            D D G N  V LSV   +  FVI  G G + + +S DREQQS+YT  ++AVDGG P  S
Sbjct: 664 TDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALS 723

Query: 697 AYVGVTINVLDENDNAPYITAP-SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755
           +   +TI +LD NDN P +  P SN S+ L+ P T  G  V++V A D D+G+NA + YS
Sbjct: 724 STAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYS 783

Query: 756 IAG--GNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP-PRYGTALVHLYV 812
           I G  G     F+I   +G ITLE+ + +  +GLHRL+VKVSD G P P + T +V+L+V
Sbjct: 784 IIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFV 843

Query: 813 NETLANRTLLETLL 826
           N+T++N + +E+LL
Sbjct: 844 NDTVSNESYIESLL 857


>gi|94538350 protocadherin 17 precursor [Homo sapiens]
          Length = 1159

 Score =  353 bits (906), Expect = 5e-97
 Identities = 245/686 (35%), Positives = 351/686 (51%), Gaps = 71/686 (10%)

Query: 62  YKVPEEQPPNTLIGSLAADY----GFPDV----------GHLYKLEVGAPYLR-VDGKTG 106
           Y VPEEQ   T+IG++  D     G P            G    LE  AP+L  VD  +G
Sbjct: 23  YSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSG 82

Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTP 166
            ++T +  IDRE L  C++      C L  EV   D        +   ++E+QDINDN P
Sbjct: 83  LLYTKQR-IDRESL--CRHNAK---CQLSLEVFAND------KEICMIKVEIQDINDNAP 130

Query: 167 NFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQV-AEDQ 225
           +F+S  I + I EN   G+ FP+  A D DAG NG+ +Y L        LFGL V +   
Sbjct: 131 SFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHG--LFGLDVKSRGD 188

Query: 226 EEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSY 285
             K P+L++   LDRE+ + + L +   DGG PPR+++  + V V+D+NDN+P FE PSY
Sbjct: 189 GTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSY 248

Query: 286 EAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNTGLITVQGP 344
             EL EN+P+G  VI + A D+D+G N E+ Y+F    P+ VR L  +D  TGLI V+G 
Sbjct: 249 LVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGN 308

Query: 345 VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANI 404
           +D E+   L   V A+D G NP  A  +V V + D NDNAP+     IG V+ + G   +
Sbjct: 309 LDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPS-----IGFVSVRQGA--L 361

Query: 405 SEDVAEETAVALVQVSDRDEGENAAVTCVV---------------AGDVPFQLRQASETG 449
           SE     T +ALV+V+DRD G+N  + C V                G VPF+L +     
Sbjct: 362 SEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEE----- 416

Query: 450 SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQS 509
            +    Y + T  PLD E   +Y + IVA D G+PPL+ST S  ++++D NDN P FT+ 
Sbjct: 417 -NYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKG 475

Query: 510 VTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP----EPAAKGLFTISPETGEIQ 565
           +  +   ENN PGE +  + A D D G N  + YS+ P    + +     +++P  G I 
Sbjct: 476 LYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIY 535

Query: 566 VKTSLDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCNDNDPKFMLSGYNFSVME- 623
              S + EQ +++E KV+A D G+P+ L+  ATV V VLD NDN P  +L        E 
Sbjct: 536 ALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAEL 595

Query: 624 NMPALSPVG----MVTVIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSFDREQ 677
            +P  + +G     V  +D D GE+ ++   +   N D  F I   +G I +   F  + 
Sbjct: 596 QVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDV 655

Query: 678 QSTYTFQLKAVDGGVPPRSAYVGVTI 703
                  +K  D G P  SA   + I
Sbjct: 656 TPVVELVVKVTDHGKPTLSAVAKLII 681



 Score =  218 bits (556), Expect = 2e-56
 Identities = 181/566 (31%), Positives = 254/566 (44%), Gaps = 41/566 (7%)

Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
           +++V + D NDNAP F     E ++SEN+  G       A+D D G N    Y   +   
Sbjct: 117 MIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH 176

Query: 325 VVRRLLRLDRNTGL----ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDM 380
            +  L    R  G     + +Q  +DRE  +     + A D G  P+SA  Q+ V V D 
Sbjct: 177 GLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDS 236

Query: 381 NDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPF 440
           NDN+P  E            +  + E+    T V  +  +D DEG N  V    +  VP 
Sbjct: 237 NDNSPVFEAPSY--------LVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPD 288

Query: 441 QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVN 500
           ++R   E  S   K   ++    LDYE+     I++ A D G  P+ +   + V+++D N
Sbjct: 289 RVR---ELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRN 345

Query: 501 DNAP-VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559
           DNAP +   SV + A  E   PG VIA +  +D DSG N +L   +       G   +  
Sbjct: 346 DNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGG 405

Query: 560 ETGEIQVKTS--------------LDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605
             G +  K                LDRE ++ Y + +VA D GSP L  T +  + +LD 
Sbjct: 406 PGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDE 465

Query: 606 NDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-GD-----FV 659
           NDN P+F    Y   V EN      +G V   D D G+N  V  S+   + GD     +V
Sbjct: 466 NDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYV 525

Query: 660 IQNGT-GTILSSLSFDREQQSTYTFQLKAVDGGVPPR-SAYVGVTINVLDENDNAPYITA 717
             N T G I +  SF+ EQ   + F++ A D G P    +   V + VLD NDNAP I  
Sbjct: 526 SVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVL 585

Query: 718 PS--NTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI 774
           P+  N + +L  P+   LG  VS V A D D G +  L Y I  GN   LF+I   SG I
Sbjct: 586 PTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEI 645

Query: 775 TLEKEIERRHHGLHRLVVKVSDRGKP 800
                       +  LVVKV+D GKP
Sbjct: 646 RTLHPFWEDVTPVVELVVKVTDHGKP 671



 Score =  189 bits (481), Expect = 9e-48
 Identities = 155/520 (29%), Positives = 228/520 (43%), Gaps = 56/520 (10%)

Query: 329 LLRLDRNTGLITVQGPVDREDLST------LRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
           LL +D ++GL+  +  +DRE L        L   V A D+          + V ++D+ND
Sbjct: 74  LLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEI------CMIKVEIQDIND 127

Query: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442
           NAP+     I +        +ISE+ A  T   L    D D GEN   T ++  D     
Sbjct: 128 NAPSFSSDQIEM--------DISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLF 179

Query: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
               ++  D  K   L     LD E+   +T+ + A+D G PP S+T  + V+V+D NDN
Sbjct: 180 GLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDN 239

Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP--EPAAKGLFTISPE 560
           +PVF      V  PEN   G V+ ++ A+DAD G N E++YS         + LF+I P+
Sbjct: 240 SPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPK 299

Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNF 619
           TG I+VK +LD E+    E+ V A D G   +     V V ++D NDN P    +S    
Sbjct: 300 TGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQG 359

Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD--------------FVIQNGTG 665
           ++ E  P  + + +V V D D G+N Q+Q  V    G               F ++    
Sbjct: 360 ALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYD 419

Query: 666 ---TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTS 722
              T+++    DRE Q  Y   + A DGG PP ++     I +LDENDN P  T      
Sbjct: 420 NFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFT---KGL 476

Query: 723 HKLLTPQTRL-GETVSQVAAEDFDSGVNAELIYSIAGG-----NPYGLFQIGSHSGAITL 776
           + L   +  + GE +  V A+D D G N  + YSI        + Y    +   +GAI  
Sbjct: 477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYA 536

Query: 777 EKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETL 816
            +             V   D G P        HL  N T+
Sbjct: 537 LRSFNFEQTKAFEFKVLAKDSGAP-------AHLESNATV 569



 Score =  113 bits (283), Expect = 8e-25
 Identities = 95/327 (29%), Positives = 136/327 (41%), Gaps = 37/327 (11%)

Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP--------------- 547
           AP  T      + PE    G VI  I       G +A L   L P               
Sbjct: 13  APALTLKNLNYSVPEEQGAGTVIGNI-------GRDARLQPGLPPAERGGGGRSKSGSYR 65

Query: 548 --EPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605
             E +A  L  +  ++G +  K  +DRE    +  K   +     + +    + V + D 
Sbjct: 66  VLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDI 125

Query: 606 NDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENA-QVQLSVEQDNGDF---VIQ 661
           NDN P F        + EN    +   + +  D D GEN  +  L    D+G F   V  
Sbjct: 126 NDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKS 185

Query: 662 NGTGTILSSL----SFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITA 717
            G GT    L    + DREQQ+ +T  L A+DGG PPRSA V + + V+D NDN+P   A
Sbjct: 186 RGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEA 245

Query: 718 PSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNP---YGLFQIGSHSGAI 774
           PS      L     LG  V  + A D D G N E++YS +   P     LF I   +G I
Sbjct: 246 PSYLVE--LPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLI 303

Query: 775 TLEKEIERRHHGLHRLVVKVSDRGKPP 801
            ++  ++   +G+  + V+  D G  P
Sbjct: 304 RVKGNLDYEENGMLEIDVQARDLGPNP 330



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 10/130 (7%)

Query: 701 VTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGN 760
           + + + D NDNAP  +  S+     ++     G      +A D D+G N    Y +   +
Sbjct: 118 IKVEIQDINDNAPSFS--SDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDD 175

Query: 761 PYGLFQI-------GSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
            +GLF +       G+    + ++K ++R     H LV+   D G+PPR  T  +++ V 
Sbjct: 176 -HGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVI 234

Query: 814 ETLANRTLLE 823
           ++  N  + E
Sbjct: 235 DSNDNSPVFE 244


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  348 bits (894), Expect = 1e-95
 Identities = 264/784 (33%), Positives = 379/784 (48%), Gaps = 47/784 (5%)

Query: 29  SPGPGGQRLLLPSMLLALLLLLAPSPG---HATRVVYKVPEEQPPNTLIGSLAADYGFPD 85
           SP P    LLLP +LL LLLL A  PG    A  +  ++ EEQP  TLIG ++A  G P 
Sbjct: 16  SPRP---HLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISA--GLP- 69

Query: 86  VGHLYKLEVGAPYLR-VDGKTGDIFTTETSIDRE-GLRECQNQLPGDPCILEFEVSITDL 143
                     AP +  +  + G    T+ +ID   G+      L  +          T +
Sbjct: 70  ------AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQ---RDRYRFTAV 120

Query: 144 VQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203
             +G+   +E  + V DIND+ P F      L +PE+T  G+ +P+  A D DAG  G  
Sbjct: 121 TPDGAT--VEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQ 178

Query: 204 SYELQAGPEAQELFGLQVAEDQEEKQ-PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262
            Y L +G  A E F L+     +    P+L+V G LDRE    Y L ++  DGGSPPR +
Sbjct: 179 GYAL-SGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRA 237

Query: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322
            ALL VT+LD ND+AP F +  Y A +SE+   G  V+QV A+D+D G N  + Y  ++ 
Sbjct: 238 QALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 297

Query: 323 PEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
                    +D +TGL+ ++ P+D E        V A+D G +P+   A V V V+D ND
Sbjct: 298 QSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 357

Query: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQ 441
           N P++ +    +    DG   +SE       VA + VSD D+G+ A V   +  G+  F 
Sbjct: 358 NQPSMTV----IFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFA 413

Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
           L       +     Y +     LD E+   Y + + A DSG+PPL +  +  + V DVND
Sbjct: 414 L------STQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 467

Query: 502 NAPVF-TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560
           NAP F  Q       PE   PG  +  +TA D D G+N ++ YSL P  A    F+I P 
Sbjct: 468 NAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAP-GAHTHWFSIDPT 526

Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
           +G I    SLD E     +L VVA D G P L  +ATV V + D NDN+P+F  + YN S
Sbjct: 527 SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNAS 586

Query: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTILSSLSFDR 675
           + E     +    VT  D D G    +  S+    G      F I   +G + ++ + DR
Sbjct: 587 LPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDR 646

Query: 676 EQ-QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGE 734
           +Q  S++ F + AVDGG      YV V ++  DENDN P        +   ++ Q+  G 
Sbjct: 647 DQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFYPREYAAS--ISAQSPPGT 702

Query: 735 TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
            V ++ A D D G +  L Y I  GN   LF +   SG +T+   + RR + + +L +  
Sbjct: 703 AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGA 762

Query: 795 SDRG 798
            D G
Sbjct: 763 EDGG 766



 Score =  255 bits (651), Expect = 2e-67
 Identities = 276/1034 (26%), Positives = 422/1034 (40%), Gaps = 120/1034 (11%)

Query: 53   SPGHATRVVYKVPEEQPPN-TLIGSLAADYGFPDVGHL----YKLEVGAP-YLRVDGKTG 106
            +P  A+    ++PE+QPP    +  +A D   PD+G      Y+L  G   + R+   TG
Sbjct: 1543 APVFASPSRVRLPEDQPPGPAALHVVARD---PDLGEAARVSYRLASGGDGHFRLHSSTG 1599

Query: 107  DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI---EVQDIND 163
             +      +DRE   E               V       +GSP     Q+    V D+ND
Sbjct: 1600 ALSVVRP-LDREQRAE--------------HVLTVVASDHGSPPRSATQVLTVSVADVND 1644

Query: 164  NTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAE 223
              P F     ++ + EN   G+      A+D D G NG  +Y    G  + E F L    
Sbjct: 1645 EAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY----GGVSSESFSL---- 1696

Query: 224  DQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERP 283
              +     L  +  LDRE  +  +LT+  QD GSPP+ +   +RV V D ND+AP F   
Sbjct: 1697 --DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1754

Query: 284  SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
                E+ E      ++  ++A+D D GAN +++Y              LD  +G      
Sbjct: 1755 HLSLEVPEGQD-PQTLTMLRASDPDVGANGQLQYRILDGDP--SGAFVLDLASGEFGTMR 1811

Query: 344  PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
            P+DRE     +  + A+D G    SA   + VTV D ND+AP   +    +         
Sbjct: 1812 PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV--------E 1863

Query: 404  ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP 463
            + EDV   T +  +Q  D D G N  VT  +             +G        L+T   
Sbjct: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE-------LRTAAA 1916

Query: 464  LDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPEN---- 518
            LD E+   YT  + AVD     PLS+T S+ + V DVND+AP F  S   +  P      
Sbjct: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976

Query: 519  NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
            + P   +A + A D D+G+NA ++Y L   P      T+   TGEI+V  S         
Sbjct: 1977 STPTLALATLRAEDRDAGANASILYRLAGTPPPGT--TVDSYTGEIRVARSPVALGPRDR 2034

Query: 579  ELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVID 638
             L +VA D G P+   T  ++V +    +  P+F  +    ++ EN P  +P+     + 
Sbjct: 2035 VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVH 2094

Query: 639  GDKGENAQVQLSVEQDN--GDFVIQNGTG--TILSSLSFDREQQSTYTFQLKAVDGGVPP 694
               G N  +  S+   N  G F IQ  TG  T+ S+   D E        L+A  GG   
Sbjct: 2095 AG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA-- 2151

Query: 695  RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAELI 753
              A+  +T+ + D NDNAP    P   +     P++R L   + QV A+D D G   ++ 
Sbjct: 2152 -FAFTVLTLTLQDANDNAPRFLRPHYVA---FLPESRPLEGPLLQVEADDLDQGSGGQIS 2207

Query: 754  YSIAGGNPY-GLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
            YS+A   P  GLF +   +G IT    ++R      RLV+  +DRG P   G+A + + V
Sbjct: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMV 2267

Query: 813  NETLANRTLL----------ETLLGHSLDTPLDIDIAGDP----EYERSKQRGNILFGVV 858
             +T  NR  +          + LLG  +      D+   P        S  +     G  
Sbjct: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRY 2327

Query: 859  AGVVAVALLIALAVLVRYCRQREAKSGYQAGKKE----TKDLYAPKPSGKASKGNKSKGK 914
             G V++   +      RY  Q  A  G   G+       +D+    P+   S       +
Sbjct: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE 2387

Query: 915  KSKSPKPVKPVEDED-EAGLQKSLKFNLMSDAPGDSPRIH----------LPLNYPPG-- 961
             +     +  V   D ++G    + ++L S A G S   +          + L +     
Sbjct: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447

Query: 962  ------SPDLGRHYRSNSPLPSIQLQPQ---SPSASKKH---QVVQDLPPANTFVGTGDT 1009
                  + D G   R+      +QLQ Q   +PS +  H    V +DLPP +T +    T
Sbjct: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507

Query: 1010 TSTGSEQYS--DYS 1021
             + GS  ++  DYS
Sbjct: 2508 DADGSRSHAAVDYS 2521



 Score =  253 bits (645), Expect = 9e-67
 Identities = 234/785 (29%), Positives = 347/785 (44%), Gaps = 84/785 (10%)

Query: 19   GPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATR-----VVYKVPEEQPPNTL 73
            GPP       + GPGG      + LL + + +     HA       +   +PE   P   
Sbjct: 1399 GPPWRALTVRAEGPGGAG----ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAA 1454

Query: 74   IGSLAA---DYGFPDVGHLYKL---EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQL 127
            + +  A   D   P+    Y+L   E   P LR+D +TG + +    +DRE         
Sbjct: 1455 LYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDRETT------- 1506

Query: 128  PGDPCILEFEVSITDLVQNGSPRL---LEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
               P +L   V  TD   N S R    +  ++ V D NDN P FASP   + +PE+   G
Sbjct: 1507 ---PALLLL-VEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPG 1561

Query: 185  SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
                  +A D D G     SY L +G +    F L  +         L V+  LDRE+  
Sbjct: 1562 PAALHVVARDPDLGEAARVSYRLASGGDGH--FRLHSSTGA------LSVVRPLDREQRA 1613

Query: 245  SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
             + LT+   D GSPPR+++ +L V+V D ND AP F++  Y   L EN+P G S++ ++A
Sbjct: 1614 EHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRA 1673

Query: 305  NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364
             D D GAN ++ Y       V      LD +TG++T    +DRE+   +  +V A+DRG+
Sbjct: 1674 TDPDVGANGQVTY-----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGS 1728

Query: 365  NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE---ETAVALVQVSD 421
             P+     V V V+D ND+APT             G A++S +V E      + +++ SD
Sbjct: 1729 PPQLTHVTVRVAVEDENDHAPTF------------GSAHLSLEVPEGQDPQTLTMLRASD 1776

Query: 422  RDEGENAAVTCVVAGDVPFQLRQASETGS---DSKKKYFLQTTTPLDYEKVKDYTIEIVA 478
             D G N        G + +++     +G+   D     F  T  PLD E    + + I A
Sbjct: 1777 PDVGAN--------GQLQYRILDGDPSGAFVLDLASGEF-GTMRPLDREVEPAFQLRIEA 1827

Query: 479  VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538
             D G P LS+T  L V V+D ND+AP F      V  PE+   G ++ ++ A D D+G+N
Sbjct: 1828 RDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887

Query: 539  AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTAT 597
              + Y L    A  G F + P +GE++   +LDREQ  SY   V A D  +   L  T +
Sbjct: 1888 GHVTYYLGAGTA--GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945

Query: 598  VLVNVLDCNDNDPKFMLSGYNFSVMENMPALS----PVGMVTVIDGDKGENAQV--QLSV 651
            V + V D ND+ P F  S     +    P+ S     +  +   D D G NA +  +L+ 
Sbjct: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAG 2005

Query: 652  EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711
                G   + + TG I  + S            + A D G P RSA   + + +  E + 
Sbjct: 2006 TPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAER 2064

Query: 712  APYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHS 771
             P    P  +S   +      G  +    A     G N  + YSI  GN  G F I   +
Sbjct: 2065 GPRF--PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPST 2121

Query: 772  GAITL 776
            GAIT+
Sbjct: 2122 GAITV 2126



 Score =  242 bits (618), Expect = 1e-63
 Identities = 245/878 (27%), Positives = 380/878 (43%), Gaps = 133/878 (15%)

Query: 90   YKLEVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
            Y L    P      VD  TG I TT   +DRE   E +  L                   
Sbjct: 2208 YSLAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMA--------------TDR 2252

Query: 147  GSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203
            GSP L+      + V D NDN P    P   L + E+  +GS       +D D+GP  V 
Sbjct: 2253 GSPALVGSATLTVMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSGP--VL 2309

Query: 204  SYELQ-AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262
             Y L  +GP+     G            ++ + G LD E+ D Y L +   DG   P   
Sbjct: 2310 WYVLSPSGPQDPFSVGRYGG--------RVSLTGPLDFEQCDRYQLQLLAHDG---PHEG 2358

Query: 263  SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322
             A L V V D NDNAP F +  Y+  L E++P G +++ V A D D GAN  I Y     
Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418

Query: 323  PEVVRRLLRLDRNTG-LITVQGPV--DREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKD 379
             +       +D N G L T+ G V    +    +   + A+D G   ++ARA V V ++D
Sbjct: 2419 ADG----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474

Query: 380  MNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT--CVVAGD 437
             ND+AP+  +    +         ++ED+   + +  ++ +D D   + A     +++G+
Sbjct: 2475 QNDHAPSFTLSHYRVA--------VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN 2526

Query: 438  ------VPFQLRQASET-GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN 490
                  +  +L +A E+ G   +    L    PLD+E +  Y + + A D G PP SS  
Sbjct: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586

Query: 491  SLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550
             + V V+DVNDN PVFT++   V  PE+   G  +  + ASDAD G +  + +++     
Sbjct: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP 2646

Query: 551  AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610
            + GLF +   +G +++  +LD E +  ++L V AAD         A V + V D ND+ P
Sbjct: 2647 S-GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGP 2704

Query: 611  KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV------EQDNGDFVIQNGT 664
             F L+  + SV EN P  + V  +  IDGD G   +++ S+       +    F + + T
Sbjct: 2705 AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSST 2764

Query: 665  GTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHK 724
            G + + + FD E   ++   + A D G    SA V V++ V  E++  P   AP+   H 
Sbjct: 2765 GELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPA--FHF 2820

Query: 725  LLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI---- 780
             +    R G ++  V A D D G +  ++YS+A  +PY  F I   +GA+ L  +     
Sbjct: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYLRVDSRAPG 2878

Query: 781  ----------ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSL 830
                        R      L ++V  RG  P   +A V + V+ T        T LG + 
Sbjct: 2879 SGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDIT-------HTALGLAP 2931

Query: 831  DTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVR---YCRQREAKSGYQ 887
            D  L                  +L G VA  + V +++ALA LV      R R+A++   
Sbjct: 2932 DLNL------------------LLVGAVAASLGVVVVLALAALVLGLVRARSRKAEA--- 2970

Query: 888  AGKKETKDLYAPKPSGK----ASKGNKSKGKKSKSPKP 921
                      AP P  +    AS   +  G++  SP P
Sbjct: 2971 ----------APGPMSQAAPLASDSLQKLGREPPSPPP 2998



 Score =  242 bits (617), Expect = 2e-63
 Identities = 221/772 (28%), Positives = 337/772 (43%), Gaps = 62/772 (8%)

Query: 59   RVVYKVPEEQPPNTLIGSLAADYGF--PDVGH----LYKLEVGAP--YLRVDGKTGDIFT 110
            R +Y+ PE  P   L GS         PD G      Y L  GA   +  +D  +G I T
Sbjct: 474  RQLYR-PEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSG-IIT 531

Query: 111  TETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDINDNTPN 167
            T  S+D E   E Q QL            I      G P L       + +QD+NDN P 
Sbjct: 532  TAASLDYE--LEPQPQL------------IVVATDGGLPPLASSATVSVALQDVNDNEPQ 577

Query: 168  FASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEE 227
            F       ++PE T  G+ F    A+D D+GP G+ SY L AG  +      ++    + 
Sbjct: 578  FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI----DA 633

Query: 228  KQPQLIVMGNLDRERW-DSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYE 286
                +     LDR++   S+D T+   DGG     S   ++V + D NDN P+F    Y 
Sbjct: 634  HSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYA 691

Query: 287  AELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVD 346
            A +S  SP G +V++++A+D DQG++  + Y  H        L  LD  +GL+TV  P+ 
Sbjct: 692  ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY--HILAGNSPPLFTLDEQSGLLTVAWPLA 749

Query: 347  REDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISE 406
            R   S ++  + A+D G       A+V +++       P  E            + ++ E
Sbjct: 750  RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE--------QLQYVFSVPE 801

Query: 407  DVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDY 466
            DVA  T+V +VQ  +   G  A VT  ++G  P  L               LQT  PLD 
Sbjct: 802  DVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVSG------LLQTLRPLDR 854

Query: 467  EKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIA 526
            E +       V   SG PP  +   ++V + DVNDN+P F      V  P N  PG  I 
Sbjct: 855  ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY 914

Query: 527  EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAAD 586
             + A D DSG N+ + ++L       G FT+ P TG +++   L      ++EL++ A D
Sbjct: 915  TLRALDPDSGVNSRVTFTLLA--GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972

Query: 587  RGSPSLQGTATVLVNVLDCNDND--PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGEN 644
             GSP       + V V D       P+F    Y   +     A + V  V     D G  
Sbjct: 973  GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP- 1031

Query: 645  AQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---V 701
                L+ E  +  F ++  +G +    + DRE Q  Y  ++ AV G         G   V
Sbjct: 1032 ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATV 1091

Query: 702  TINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAG-GN 760
             +++L++N+++P ++   + +   +      G +V +V A D DSG N  L YS+     
Sbjct: 1092 RVSILNQNEHSPRLS--EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149

Query: 761  PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
                F+I   +G +T  + ++R     ++L+V+V D G PPR  T  VH+ V
Sbjct: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAV 1201



 Score =  227 bits (579), Expect = 4e-59
 Identities = 207/695 (29%), Positives = 300/695 (43%), Gaps = 65/695 (9%)

Query: 134  LEFEVS-----ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNI-GSLF 187
            L+FEVS     +      G+       + +QD NDN P F  P     +PE+  + G L 
Sbjct: 2132 LDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLL 2191

Query: 188  PIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD 247
             +  A D D G  G  SY L A   A+ LF +      +     +     LDRE W    
Sbjct: 2192 QVE-ADDLDQGSGGQISYSLAASQPARGLFHV------DPTTGTITTTAILDREIWAETR 2244

Query: 248  LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307
            L +   D GSP    SA L V V+DTNDN P   +P +E  +SE++ +G  + QV  ND 
Sbjct: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDV 2303

Query: 308  DQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK 367
            D G        +  +P   +    + R  G +++ GP+D E     +  +LA D    P 
Sbjct: 2304 DSGP----VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPH 2356

Query: 368  SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
              RA + V V+D+NDNAP          +       + E     +A+  V  +DRD G N
Sbjct: 2357 EGRANLTVLVEDVNDNAPAF--------SQSLYQVMLLEHTPPGSAILSVSATDRDSGAN 2408

Query: 428  AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQT---TTPLDYEKVKDYTIEIVAVDSGNP 484
                    G + + L   ++  S       L T   T  L ++      + + A D G P
Sbjct: 2409 --------GHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460

Query: 485  PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNAELVY 543
              ++  ++ VQ+ D ND+AP FT S   VA  E+  PG  +  + A+DAD S S+A + Y
Sbjct: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520

Query: 544  S-----------LEPEPAAKGLFTISP---ETGEIQVKTSLDREQRESYELKVVAADRGS 589
            S           LEP  A  G  +  P     G + +   LD E    Y L V AADRG 
Sbjct: 2521 SIISGNWGRVFQLEPRLAEAGE-SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ 2579

Query: 590  PSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQL 649
            P       V V VLD NDN P F  + Y  +V E+ P  + +  V   D D G +  V+ 
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639

Query: 650  SVE--QDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
            +V     +G F +   +GT+  + + D E Q+ +   ++A D       A   VTI V D
Sbjct: 2640 TVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD-PAGAHFALAPVTIEVQD 2698

Query: 708  ENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI--AGGNPYG-- 763
             ND+ P    P N     +      G  V+ + A D D+G    L YS+  AG  P G  
Sbjct: 2699 VNDHGP--AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756

Query: 764  LFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
             F + S +G +      +  H    RL+V  +D G
Sbjct: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2791



 Score =  216 bits (551), Expect = 7e-56
 Identities = 218/775 (28%), Positives = 331/775 (42%), Gaps = 59/775 (7%)

Query: 51   APSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFT 110
            AP+ G A  +  +VPE Q P TL    A+D   PDVG   +L+    Y  +DG     F 
Sbjct: 1748 APTFGSA-HLSLEVPEGQDPQTLTMLRASD---PDVGANGQLQ----YRILDGDPSGAFV 1799

Query: 111  TETSIDREG-LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFA 169
             + +    G +R    ++  +P   +  +   D  Q      L   + V D ND+ P F 
Sbjct: 1800 LDLASGEFGTMRPLDREV--EPAF-QLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856

Query: 170  SPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQ 229
             P  ++ +PE+   G+L     A D DAG NG  +Y L AG     L         E   
Sbjct: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLL--------EPSS 1908

Query: 230  PQLIVMGNLDRERWDSYDLTIKVQDGGSP-PRASSALLRVTVLDTNDNAPKFERPSYEAE 288
             +L     LDRE+  SY  ++   DG +  P +++  + +TV D ND+AP F        
Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLR 1968

Query: 289  LSENSPIGHS----VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITV-QG 343
            L    P   +    +  ++A D D GANA I Y     P     +   D  TG I V + 
Sbjct: 1969 LPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV---DSYTGEIRVARS 2025

Query: 344  PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
            PV       + F ++A D G   +SA   ++V ++   +  P                A 
Sbjct: 2026 PVALGPRDRVLF-IVATDLGRPARSATGVIIVGLQGEAERGPRFP--------RASSEAT 2076

Query: 404  ISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTT 462
            I E+    T +   +      G N  +T  +++G+          TG+ +     +++  
Sbjct: 2077 IRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAIT-----VRSAE 2130

Query: 463  PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522
             LD+E V      ++  +SG     +  +L +Q  D NDNAP F +       PE+    
Sbjct: 2131 GLDFE-VSPRLRLVLQAESGGAFAFTVLTLTLQ--DANDNAPRFLRPHYVAFLPESRPLE 2187

Query: 523  EVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKV 582
              + ++ A D D GS  ++ YSL     A+GLF + P TG I     LDRE      L +
Sbjct: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247

Query: 583  VAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
            +A DRGSP+L G+AT+ V V+D NDN P  +   +   V E+    S +  VT  D D G
Sbjct: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSG 2306

Query: 643  ENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702
                  LS       F +    G +  +   D EQ   Y  QL A DG   P      +T
Sbjct: 2307 PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLT 2363

Query: 703  INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPY 762
            + V D NDNAP  +   +    +L   T  G  +  V+A D DSG N  + Y +A  +P 
Sbjct: 2364 VLVEDVNDNAPAFS--QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLA--SPA 2419

Query: 763  GLFQIGSHSGAI-TLEKEIERRHHGLHR--LVVKVSDRGKPPRYGTALVHLYVNE 814
              F +  ++G + T+   +   H G     +V++  D G P R   A VH+ + +
Sbjct: 2420 DGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474



 Score =  207 bits (528), Expect = 3e-53
 Identities = 161/545 (29%), Positives = 239/545 (43%), Gaps = 26/545 (4%)

Query: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
           S + ++ E  P G  +  + A      A   + +   Q    V   L +D ++G++    
Sbjct: 46  SLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105

Query: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
            +DRE     RF+ +       P  A  +V V V D+ND+AP        L         
Sbjct: 106 VLDREQRDRYRFTAVT------PDGATVEVTVRVADINDHAPAFPQARAAL--------Q 151

Query: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ-LRQASETGSDSKKKYFLQTTT 462
           + E  A  T   L    D D G        ++GD   +  R  +  G D      L  T 
Sbjct: 152 VPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTG 211

Query: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522
            LD E    Y +++ A D G+PP  +   L V ++D+ND+AP F QS       E+  PG
Sbjct: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271

Query: 523 EVIAEITASDADSGSNAELVYSLEPEPA-AKGLFTISPETGEIQVKTSLDREQRESYELK 581
             + ++ ASDAD+G N  + Y +    +   G F+I   TG +Q++  LD EQR  +EL 
Sbjct: 272 SPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331

Query: 582 VVAADRGSPSLQGTATVLVNVLDCNDNDPK----FMLSGYNFSVMENMPALSPVGMVTVI 637
           V A D G+    G+A V V+V D NDN P     F+ +  +  V E  P    V  ++V 
Sbjct: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391

Query: 638 DGDKGENAQVQLSVEQDNGDFVIQNGTGTILS---SLSFDREQQSTYTFQLKAVDGGVPP 694
           D D G+ A V +S+E   G F +      I     +   DRE++  Y  ++ A D G PP
Sbjct: 392 DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451

Query: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GETVSQVAAEDFDSGVNAELI 753
             A     ++V D NDNAP           L  P+  L G  V +V A D D G N ++ 
Sbjct: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPL--PEVALPGSFVVRVTARDPDQGTNGQVT 509

Query: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
           YS+A G     F I   SG IT    ++       +L+V  +D G PP   +A V + + 
Sbjct: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569

Query: 814 ETLAN 818
           +   N
Sbjct: 570 DVNDN 574



 Score =  197 bits (500), Expect = 6e-50
 Identities = 190/682 (27%), Positives = 288/682 (42%), Gaps = 51/682 (7%)

Query: 155  QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
            ++ VQD+      P F SP   + +P  T  G+      A   D GP    +Y L A   
Sbjct: 985  RVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHL-AAEG 1040

Query: 213  AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP---RASSALLRVT 269
            A   FGL      E +   L V   LDRE  + Y L +    G       +  +A +RV+
Sbjct: 1041 ASSPFGL------EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVS 1094

Query: 270  VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
            +L+ N+++P+         ++EN P G SV +V A D D G N  + Y+  Q  E   + 
Sbjct: 1095 ILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED-SKA 1153

Query: 330  LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEI 389
             R+   TG +T    +DRE  S+ +  V  +D G+ P+S    V V V D+NDN+PT  +
Sbjct: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF-L 1212

Query: 390  RGIGLVTHQDGMA-NISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448
            +  G      G+   + + V   T V  +Q  D DEGEN  +   + G         SE 
Sbjct: 1213 QASGAAG--GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGP-------GSEL 1263

Query: 449  GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV----------D 498
             S       L T  PL   +   Y + + A D G+PP S++  L VQV+          D
Sbjct: 1264 FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPD 1323

Query: 499  VNDNAPVFTQSVT-EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTI 557
            + +  P     V   V   E  +PG ++  + A +  +G  A L Y+L      +G F +
Sbjct: 1324 LAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVGGADPEGTFAL 1381

Query: 558  SPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGY 617
               +G + +   LD E    +    V A+    +      V V V D N++ P F     
Sbjct: 1382 DAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPL 1441

Query: 618  NFSVMENMPALSPVGMVTVIDGD-KGENAQVQ---LSVEQDNGDFVIQNGTGTILSSLSF 673
              ++ EN    + +      D D  G N+ V+   L  E       +   TG + +    
Sbjct: 1442 ALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGL 1501

Query: 674  DREQQSTYTFQLKAVD---GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT 730
            DRE        ++A D        R+A V   + V DENDNAP   +PS      L    
Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVR---LPEDQ 1558

Query: 731  RLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRL 790
              G     V A D D G  A + Y +A G   G F++ S +GA+++ + ++R     H L
Sbjct: 1559 PPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVL 1617

Query: 791  VVKVSDRGKPPRYGTALVHLYV 812
             V  SD G PPR  T ++ + V
Sbjct: 1618 TVVASDHGSPPRSATQVLTVSV 1639



 Score =  189 bits (479), Expect = 2e-47
 Identities = 199/774 (25%), Positives = 334/774 (43%), Gaps = 88/774 (11%)

Query: 61   VYKVPEEQPPNTLIGSLAADYGFPDVGHL-YKLEVGAP--YLRVDGKTGDIFTTETSIDR 117
            V+ VPE+  P T +G + A      +  +   L  G P     +D  +G +  T   +DR
Sbjct: 796  VFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSG-LLQTLRPLDR 854

Query: 118  EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV--QDINDNTPNFASPVITL 175
            E L            +LE EV     V    P     ++ V   D+NDN+P F +P  T+
Sbjct: 855  ELLGP----------VLELEVRAGSGVP---PAFAVARVRVLLDDVNDNSPAFPAPEDTV 901

Query: 176  AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235
             +P NT  G+      A D D+G N   ++ L AG           A   +     + +M
Sbjct: 902  LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGG--------AFTVDPTTGHVRLM 953

Query: 236  GNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD--TNDNAPKFERPSYEAELSENS 293
              L      +++L ++ +DGGSPPR S   LRV V D  T   AP+F  P+Y  +L   +
Sbjct: 954  RPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGT 1013

Query: 294  PIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRE--DLS 351
              G  V+QV+A   D G       T+H A E       L+  +G + V+  +DRE  +L 
Sbjct: 1014 TAGTQVLQVQAQAPDGG-----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELY 1068

Query: 352  TLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
             L+   ++  +     ++  A V V++ + N+++P +        +       ++E+   
Sbjct: 1069 ILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL--------SEDPTFLAVAENQPP 1120

Query: 411  ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSK------KKYFLQTTTPL 464
             T+V  V  +DRD G N  +T        + L+Q SE   DSK      +   + T   L
Sbjct: 1121 GTSVGRVFATDRDSGPNGRLT--------YSLQQLSE---DSKAFRIHPQTGEVTTLQTL 1169

Query: 465  DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV------TEVAFPEN 518
            D E+   Y + +   D G+PP S+T ++ V V+D+NDN+P F Q+         +  P+ 
Sbjct: 1170 DREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDR 1229

Query: 519  NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
              PG ++  + A D D G N  ++Y+L   P ++ LF++ P +GE+     L R +R  Y
Sbjct: 1230 VPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSE-LFSLHPHSGELLTAAPLIRAERPHY 1287

Query: 579  ELKVVAADRGSPSLQGTATVLVNVL----------DCNDNDPKFMLS-GYNFSVMENMPA 627
             L + A D+GSP    +  +LV VL          D  + DP   +      +  E +  
Sbjct: 1288 VLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347

Query: 628  LSPVGMVTVID-GDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLK 686
             S +G V   +    G      +      G F +   +G +  +   D E    +     
Sbjct: 1348 GSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTV 1407

Query: 687  AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT-RLGETVSQVAAEDFD 745
              +G     +  + V + V DEN++AP   A +     L  P+    G  +    A D D
Sbjct: 1408 RAEGPGGAGARLLRVQVQVQDENEHAP---AFARDPLALALPENPEPGAALYTFRASDAD 1464

Query: 746  S-GVNAELIYSIAGGN-PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
              G N+++ Y +     P    ++ + +GA++  + ++R       L+V+ +DR
Sbjct: 1465 GPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR 1518



 Score =  187 bits (476), Expect = 3e-47
 Identities = 175/649 (26%), Positives = 283/649 (43%), Gaps = 74/649 (11%)

Query: 166  PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ-AGPEAQELFGLQVAED 224
            P F       ++PE+   G+   I  A +    P  +A   L  +G + + LF L     
Sbjct: 788  PIFEQLQYVFSVPEDVAPGTSVGIVQAHNP---PGRLAPVTLSLSGGDPRGLFSLDAVSG 844

Query: 225  QEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-GSPPRASSALLRVTVLDTNDNAPKFERP 283
                   L  +  LDRE      L ++V+ G G PP  + A +RV + D NDN+P F  P
Sbjct: 845  L------LQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897

Query: 284  SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
                 L  N+  G  +  ++A D D G N+ + +T             +D  TG + +  
Sbjct: 898  EDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVDPTTGHVRLMR 954

Query: 344  PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND-------NAPTIEIRGIGLVT 396
            P+           + A+D G+ P+++  ++ V V+D+         N+PT  +       
Sbjct: 955  PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV------- 1007

Query: 397  HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
                  ++       T V  VQ    D G             PF L   S          
Sbjct: 1008 ------DLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG--------- 1052

Query: 457  FLQTTTPLDYEKVKDYTIEIVAVDSGNPPL---SSTNSLKVQVVDVNDNAPVFTQSVTEV 513
            +L     LD E  + Y ++++AV      L   + T +++V +++ N+++P  ++  T +
Sbjct: 1053 WLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFL 1112

Query: 514  AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE 573
            A  EN  PG  +  + A+D DSG N  L YSL+        F I P+TGE+    +LDRE
Sbjct: 1113 AVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE 1172

Query: 574  QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS------GYNFSVMENMPA 627
            Q+ SY+L V   D GSP    T TV V VLD NDN P F+ +      G    V + +P 
Sbjct: 1173 QQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPP 1232

Query: 628  LSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTYTFQLK 686
             + V  +   D D+GEN  +  ++     + F +   +G +L++    R ++  Y   L 
Sbjct: 1233 GTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLS 1292

Query: 687  AVDGGVPPRSAYVGVTINVL-------------DENDNAPYITAPSNTSHKLLTPQTRLG 733
            A D G PPRSA + + + VL             + +  AP     + T+ + L P + LG
Sbjct: 1293 AHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLG 1352

Query: 734  ETVSQVAAEDFDSGVNAELIYSIAGG-NPYGLFQIGSHSGAITLEKEIE 781
                 VAA +  +GV A L Y++ GG +P G F + + SG + L + ++
Sbjct: 1353 ----SVAAPE-PAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLD 1395



 Score =  144 bits (364), Expect = 3e-34
 Identities = 147/573 (25%), Positives = 249/573 (43%), Gaps = 75/573 (13%)

Query: 66   EEQPPNTLIGSLAA-DYGFPDVGHL-YKLEVGAPYLRVDGKTGDIFTTETSI----DREG 119
            E  PP + I S++A D      GH+ Y L   A    VD   G +FT   ++    D  G
Sbjct: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG 2446

Query: 120  LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPE 179
                          ++  +   D    G        +++QD ND+ P+F      +A+ E
Sbjct: 2447 A-------------VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493

Query: 180  NTNIGSLFPIPLASDRDAGPNGVA-SYELQAGPEAQELFGLQ--VAEDQEEKQPQ----- 231
            +   GS      A+D D   +  A  Y + +G   + +F L+  +AE  E   P      
Sbjct: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPRLAEAGESAGPGPRALG 2552

Query: 232  -LIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290
             L+++  LD E    Y+LT+   D G PP++S   + VTVLD NDN P F R SY   + 
Sbjct: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612

Query: 291  ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350
            E++P+G  ++ V+A+D+D G +  + +T          L  LD ++G + +   +D E  
Sbjct: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP--SGLFELDESSGTLRLAHALDCETQ 2670

Query: 351  STLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
            +  +  V A D       A A V + V+D+ND+ P   +  +          +++E+   
Sbjct: 2671 ARHQLVVQAAD-PAGAHFALAPVTIEVQDVNDHGPAFPLNLLS--------TSVAENQPP 2721

Query: 411  ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTT-------P 463
             T V  +   D D G          G + + L +A   G + ++ + L ++T       P
Sbjct: 2722 GTLVTTLHAIDGDAG--------AFGRLRYSLLEAG-PGPEGREAFALNSSTGELRARVP 2772

Query: 464  LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523
             DYE  + + + + A D+GN  LS++ ++ V V   ++  PVF         PE  + G 
Sbjct: 2773 FDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGH 2830

Query: 524  VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL------------- 570
             +  + A+D D G++  ++YSL     +   F I+  TG + ++                
Sbjct: 2831 SLGHVQATDEDGGADGLVLYSL---ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGG 2887

Query: 571  DREQRES-YELKVVAADRGSPSLQGTATVLVNV 602
             R +RE+  EL++    RG      +ATV V V
Sbjct: 2888 GRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920



 Score =  117 bits (292), Expect = 7e-26
 Identities = 99/345 (28%), Positives = 153/345 (44%), Gaps = 25/345 (7%)

Query: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFT---ISPETGEIQVKT 568
           ++   E    G +I +I+A    +G+ A L+Y +  +  + G+ T   I   +G ++   
Sbjct: 48  DLQIDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGS-GVGTDLAIDEHSGVVRTAR 105

Query: 569 SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628
            LDREQR+ Y    V  D        T  V V V D ND+ P F  +     V E+    
Sbjct: 106 VLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEHTAFG 159

Query: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGT-----GTILSSL----SFDREQQS 679
           +   +    D D G       ++  D      +  T     GT +  L      DRE +S
Sbjct: 160 TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRS 219

Query: 680 TYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQV 739
            Y  QL+A DGG PPR A   + + +LD ND+AP      +  H +++     G  V QV
Sbjct: 220 HYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFN--QSRYHAVVSESLAPGSPVLQV 277

Query: 740 AAEDFDSGVNAELIYSI--AGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
            A D D+GVN  + Y I        G F I +H+G + LE+ ++     +H LVV+  D 
Sbjct: 278 FASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDG 337

Query: 798 GKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDP 842
           G  P  G+A V ++V +   N+  + T++  S D    +  A  P
Sbjct: 338 GAHPELGSAFVTVHVRDANDNQPSM-TVIFLSADGSPQVSEAAPP 381



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 52/216 (24%), Positives = 78/216 (36%), Gaps = 19/216 (8%)

Query: 64   VPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLREC 123
            V E QPP TL+ +L A  G  D G   +L           +  + F   +S       E 
Sbjct: 2715 VAENQPPGTLVTTLHAIDG--DAGAFGRLRYSLLEAGPGPEGREAFALNSSTG-----EL 2767

Query: 124  QNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDI----NDNTPNFASPVITLAIPE 179
            + ++P D    E   S   LV       L   + V  +    ++  P F +P     +PE
Sbjct: 2768 RARVPFD---YEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPE 2824

Query: 180  NTNIGSLFPIPLASDRDAGPNGVASYELQAGPE----AQELFGLQVAEDQEEKQPQLIVM 235
                G       A+D D G +G+  Y L          Q    L +  D           
Sbjct: 2825 GARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATS 2884

Query: 236  GNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTV 270
            G   R R ++  +L ++V   G  P + SA + VTV
Sbjct: 2885 GGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  343 bits (881), Expect = 4e-94
 Identities = 258/802 (32%), Positives = 391/802 (48%), Gaps = 58/802 (7%)

Query: 41  SMLLALLLLLAPSPGHA------TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEV 94
           S LL +  LL+  PG A       R V++V EEQPP TL+G++    GF      Y+L  
Sbjct: 22  SQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPGFT-----YRLSE 76

Query: 95  GAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRL-LE 153
                 ++  TG ++TT T IDRE L       P D   L        +V + +P    E
Sbjct: 77  SHALFAINSSTGALYTTST-IDRESL-------PSDVINL--------VVLSSAPTYPTE 120

Query: 154 GQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGV--ASYELQAGP 211
            ++ V+D+NDN P F  P I +   E+++ G    +  A+D D G NGV   SY +  G 
Sbjct: 121 VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180

Query: 212 EAQEL-FGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTV 270
           EA      + +    E     L+  G LDRE    Y L ++V+D G P R     + VTV
Sbjct: 181 EAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTV 240

Query: 271 LDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLL 330
            D NDN P F    Y+A + E++ +G SV+QV A D+D+G NA+I Y             
Sbjct: 241 QDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP----F 296

Query: 331 RLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIR 390
           ++D  TGLITV+ P+D E       +V A DRG    + RA+ ++ + D+NDN P ++ R
Sbjct: 297 QMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFR 356

Query: 391 GIGLVTHQDGMANISEDVAEETAVALVQVSDRDE-GENAAVTCVVAGDVPFQLRQASETG 449
                +     A++ E+    T VAL+ V+D D    N  ++  + G    + R      
Sbjct: 357 YFPATSR---YASVDENAQVGTVVALLTVTDADSPAANGNISVQILGG--NEQRHFEVQS 411

Query: 450 SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDS-GNPP------LSSTNSLKVQVVDVNDN 502
           S       ++  + LD E++  Y + +   D+ G PP       SS  SL + V D+ND+
Sbjct: 412 SKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDH 471

Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
            PVF+Q V  V   E   PG  ++ I+A+D DSG NA L YS+       G F IS  +G
Sbjct: 472 PPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSI-VSGNGLGWFHISEHSG 530

Query: 563 EIQVKTS--LDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNF 619
            +   +S  LDRE      L + A D+G       A ++V +LD ND  P F    GY+ 
Sbjct: 531 LVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDV 590

Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSFDRE 676
           SV+EN P  + + M+   DGD G+N  V+ S+   E D   F +   +G + +  S DRE
Sbjct: 591 SVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE 650

Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736
           +Q+ Y+  + A D G PP+S+   + +++LD NDN+P        +H  +      G  +
Sbjct: 651 EQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAH--IKENEPGGSYI 708

Query: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
           + V+A D D G N  + YSI+ G+    FQ+ + SG I+    ++R     ++L +  +D
Sbjct: 709 TTVSATDPDLGTNGTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD 767

Query: 797 RGKPPRYGTALVHLYVNETLAN 818
            G       A+V + V +T  N
Sbjct: 768 GGNLQSPNQAIVTITVLDTQDN 789



 Score =  290 bits (743), Expect = 4e-78
 Identities = 229/764 (29%), Positives = 367/764 (48%), Gaps = 79/764 (10%)

Query: 90  YKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSIT-DLVQNGS 148
           Y+L+      ++D +TG + T    +D E  R+                S+T   +  G 
Sbjct: 287 YRLQDEGTPFQMDPETG-LITVREPLDFEARRQ---------------YSLTVQAMDRGV 330

Query: 149 PRLL---EGQIEVQDINDNTP-----NFASPVITLAIPENTNIGSLFPIPLASDRDA-GP 199
           P L    E  I++ D+NDN P      F +     ++ EN  +G++  +   +D D+   
Sbjct: 331 PSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAA 390

Query: 200 NGVASYELQAGPEAQELFGLQVAEDQEEKQPQLI---VMGNLDRERWDSYDLTIKVQDG- 255
           NG  S ++  G E +        E Q  K P L    V   LDRER  SY+LT+ V D  
Sbjct: 391 NGNISVQILGGNEQRHF------EVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNY 444

Query: 256 GSPP------RASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQ 309
           G+PP      R+S A L + V D ND+ P F +  Y   LSE +P G  V  + A D D 
Sbjct: 445 GAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDS 504

Query: 310 GANAEIEYTFHQAPEVVRRLLRLDRNTGLITV--QGPVDREDLSTLRFSVLAKDRGTNPK 367
           G NA + Y+      +      +  ++GL+T    G +DRE  S +  ++ A+D+G +PK
Sbjct: 505 GLNANLRYSIVSGNGL--GWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPK 562

Query: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGM-ANISEDVAEETAVALVQVSDRDEGE 426
            + AQ+VVT+ D+ND  P          +  +G   ++ E+    T + +++ +D D G+
Sbjct: 563 VSYAQLVVTLLDVNDEKPVF--------SQPEGYDVSVVENAPTGTELLMLRATDGDLGD 614

Query: 427 NAAVTCVVAGDVPFQLRQASETGSDSKK----KYFLQTTTPLDYEKVKDYTIEIVAVDSG 482
           N        G V F L++A ET   S +       L T + LD E+   Y++ ++A D G
Sbjct: 615 N--------GTVRFSLQEA-ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665

Query: 483 NPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELV 542
           +PP SS   + V ++D+NDN+PVF          EN   G  I  ++A+D D G+N  + 
Sbjct: 666 SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVK 725

Query: 543 YSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNV 602
           YS+     ++  F ++ ++G I  + +LDRE++ +Y+L++VA D G+      A V + V
Sbjct: 726 YSISAGDRSR--FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITV 783

Query: 603 LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQN 662
           LD  DN P F    Y+F V EN+     VG V+    D   N    ++     G F I  
Sbjct: 784 LDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQ 843

Query: 663 GTGTILSSLSFDREQQSTYTFQLKAV-DGGVPPRSAYVGVTINVLDENDNAPYITAPSNT 721
            TG + ++   DRE+QS Y  QLK V  GG       V +T+   D NDN+P+      +
Sbjct: 844 VTGQLTTANVIDREEQSFY--QLKVVASGGTVTGDTMVNITVK--DLNDNSPHFLQAIES 899

Query: 722 SHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781
            +  +    + G ++ Q  A D D GVN  ++YS+   NP  LF I   +G I+L   ++
Sbjct: 900 VN--VVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK-QNPKNLFAINEKNGTISLLGPLD 956

Query: 782 RRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETL 825
             H G +++ +  SD G P    + ++ +YV++   N  + + L
Sbjct: 957 -VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL 999



 Score =  290 bits (741), Expect = 6e-78
 Identities = 224/688 (32%), Positives = 324/688 (47%), Gaps = 53/688 (7%)

Query: 135  EFEVSITDLVQNGSPRLLEGQI---EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPL 191
            + E+  +D+   G P+L    I    V D+NDN+P F      + + E+  + S F    
Sbjct: 963  QIEILASDM---GVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQ 1019

Query: 192  ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIK 251
            ASD+D+G NG  +Y +  G    + FG+           QL +   LDRE  D Y L + 
Sbjct: 1020 ASDKDSGANGEIAYTIAEG-NTGDAFGIF-------PDGQLYIKSELDRELQDRYVLMVV 1071

Query: 252  VQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGA 311
              D    P +++  + V + D NDN P F   +Y     E    G  V +V A D D G 
Sbjct: 1072 ASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGP 1131

Query: 312  NAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLR------FSVLAKDRGT- 364
            N E+ Y+F    E+V+    L   +G IT     DRE L   R      F+V+A D+G  
Sbjct: 1132 NGEVRYSF----EMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIP 1187

Query: 365  NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDE 424
             P   +A V V +KD+NDNAP                A ISE  A  T V  V  SD DE
Sbjct: 1188 QPLKDQATVHVYMKDINDNAPKF--------LKDFYQATISESAANLTQVLRVSASDVDE 1239

Query: 425  GENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGN 483
            G N  +   ++ G+   Q    S +G        +     LDYE    Y++ I AVDSG 
Sbjct: 1240 GNNGLIHYSIIKGNEERQFAIDSTSGQ-------VTLIGKLDYEATPAYSLVIQAVDSGT 1292

Query: 484  PPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVY 543
             PL+ST +L + ++D NDN P F +S   V   EN + GE+++ +TA+D+DSG NA+L Y
Sbjct: 1293 IPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYY 1352

Query: 544  SLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVL 603
            S+       G F+ISP TG I +   LD E +  Y+L + A D+G P    T +V+++V 
Sbjct: 1353 SI-TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVR 1411

Query: 604  DCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD---NGDFVI 660
            D NDN P F       S++EN+P  + V  VT  D D   N Q+  ++ Q       F I
Sbjct: 1412 DFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471

Query: 661  QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP---PRSAYVGVTINVLDENDNAPYITA 717
                GTI ++   DRE  + +   +KA D  VP    R A   VTI V D NDN P   +
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531

Query: 718  PSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777
             +  +     P   +G  ++ + A D D G N E+ Y I  G+    F +  +SG + + 
Sbjct: 1532 QNALA---ADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT-DTFIVDRYSGDLRVA 1587

Query: 778  KEIERRHHGLHRLVVKVSDRGKPPRYGT 805
              +      ++ L+V  +D G   R  T
Sbjct: 1588 SALVPSQL-IYNLIVSATDLGPERRKST 1614



 Score =  284 bits (726), Expect = 4e-76
 Identities = 222/762 (29%), Positives = 351/762 (46%), Gaps = 58/762 (7%)

Query: 64   VPEEQPPNTLIGSLAADYGFPDVGH----LYKLEVG-APYLRVDGKTGDIFTTETSIDRE 118
            + E +P  + I +++A    PD+G      Y +  G     +V+ ++G + +T  ++DRE
Sbjct: 698  IKENEPGGSYITTVSATD--PDLGTNGTVKYSISAGDRSRFQVNAQSG-VISTRMALDRE 754

Query: 119  GLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIP 178
                       +    + ++  TD     SP      I V D  DN P F+    +  + 
Sbjct: 755  -----------EKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVF 803

Query: 179  ENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNL 238
            EN  +G       AS  D   N   SY +  G + + +F +       +   QL     +
Sbjct: 804  ENVALGYHVGSVSASTMDLNSN--ISYLITTGDQ-KGMFAIN------QVTGQLTTANVI 854

Query: 239  DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
            DRE    Y L + V  GG+       ++ +TV D NDN+P F +      + EN   GHS
Sbjct: 855  DREEQSFYQLKV-VASGGTV--TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHS 911

Query: 299  VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVL 358
            + Q KA D D+G N  + Y+  Q P   + L  ++   G I++ GP+D     + +  +L
Sbjct: 912  IFQAKAVDPDEGVNGMVLYSLKQNP---KNLFAINEKNGTISLLGPLDVH-AGSYQIEIL 967

Query: 359  AKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQ 418
            A D G    S+   + V V D+NDN+P  +     +         +SE     +    VQ
Sbjct: 968  ASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVT--------LSESEPVNSRFFKVQ 1019

Query: 419  VSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVA 478
             SD+D G N  +   +A             G        L   + LD E    Y + +VA
Sbjct: 1020 ASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQ-------LYIKSELDRELQDRYVLMVVA 1072

Query: 479  VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538
             D    PLS+T ++ V + DVNDN P+F  +     F E  + G  + +++A D D G N
Sbjct: 1073 SDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPN 1132

Query: 539  AELVYSLEPEPAAKGLFTISPE---TGEIQVKTSLDREQRESYELKVVAADRGSPS-LQG 594
             E+ YS E       L  IS E   T +   ++ + R     +   V+A D+G P  L+ 
Sbjct: 1133 GEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKD 1192

Query: 595  TATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD 654
             ATV V + D NDN PKF+   Y  ++ E+   L+ V  V+  D D+G N  +  S+ + 
Sbjct: 1193 QATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKG 1252

Query: 655  NGD--FVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNA 712
            N +  F I + +G +      D E    Y+  ++AVD G  P ++   + I++LDENDN 
Sbjct: 1253 NEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNT 1312

Query: 713  PYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSG 772
            P  + P +T    +    R+GE VS V A D DSG NA+L YSI G N +G F I  ++G
Sbjct: 1313 P--SFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTG 1370

Query: 773  AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814
            +I L K+++     L++L +   D+G+PPR  T  V ++V +
Sbjct: 1371 SIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412



 Score =  276 bits (705), Expect = 1e-73
 Identities = 213/674 (31%), Positives = 322/674 (47%), Gaps = 53/674 (7%)

Query: 138  VSITDLVQNGSPRLL---EGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASD 194
            V + DL Q  + R     +  I + D+NDN P F SP +T  IPENT I ++     A+D
Sbjct: 2018 VQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATD 2076

Query: 195  RDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD 254
             D+GPN    Y L   P   + F +   + +        + G LDRE   +Y LT+   D
Sbjct: 2077 PDSGPNSYIEYTL-LNPLGNK-FSIGTIDGEVR------LTGELDREEVSNYTLTVVATD 2128

Query: 255  GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314
             G P  +SS  + V VLD NDN P F +  Y+ E++EN+  G  +IQV A D D+G N +
Sbjct: 2129 KGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQ 2188

Query: 315  IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374
            + Y          +  R+D  TG ITV  P+DRE   T   +V A DRG+ P++  + V 
Sbjct: 2189 VRYGIVNGN--TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVS 2246

Query: 375  VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS-DRDEGENAAVTCV 433
            + + D+ND  P  E+    +        N+ E++       L  V+ D D G N+ ++ V
Sbjct: 2247 IVLLDINDFVPVFELSPYSV--------NVPENLGTLPRTILQVVARDDDRGSNSKLSYV 2298

Query: 434  VAG---DVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN 490
            + G   D  F L  + E G           T  LD E  + + + I A DSG+P L+ T 
Sbjct: 2299 LFGGNEDNAFTLSASGELG----------VTQSLDRETKERFVLMITATDSGSPALTGTG 2348

Query: 491  SLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550
            ++ V V DVNDN P F         PE+   G  +  + ASDAD+  NA +         
Sbjct: 2349 TINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII-----G 2403

Query: 551  AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCNDND 609
                FTI+P TG+I     LDRE +++Y L VV +D GSP  L  + +VLV V D NDN 
Sbjct: 2404 GNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNP 2463

Query: 610  PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTIL 668
            P+F    Y   +       S V  VTV D D G N+++  S+   N + F I    G I+
Sbjct: 2464 PRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIM 2523

Query: 669  SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728
            ++   +   + T++  +K  DGG  P++    VT+  +++ D  P + A   T    + P
Sbjct: 2524 AAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQT---FMFP 2577

Query: 729  QTRLGETVSQVAAEDFDSGVNAE-LIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGL 787
            +    + VS +      S +  E + Y IA GN    FQI   +G +++ + ++      
Sbjct: 2578 EN---QPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQK 2634

Query: 788  HRLVVKVSDRGKPP 801
            + + ++  D G PP
Sbjct: 2635 YVVWIEARDGGFPP 2648



 Score =  274 bits (701), Expect = 3e-73
 Identities = 216/706 (30%), Positives = 326/706 (46%), Gaps = 55/706 (7%)

Query: 100  RVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159
            R+D ++GD+  T   +DRE   +    +  D           D +Q+   R+    I V 
Sbjct: 1788 RIDPESGDLIATRR-LDRERRSKYSLLVRAD-----------DGLQSSDMRI---NITVS 1832

Query: 160  DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGL 219
            D+ND+TP F+ PV +  IPE+T  GSL    LA+D D+G NG  +Y +    E    F  
Sbjct: 1833 DVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLN 1892

Query: 220  QVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPK 279
             +            +   LD E    Y LT++ +DGG   + ++  +   +LD NDN P 
Sbjct: 1893 PITG-------VFNLTRLLDYEVQQYYILTVRAEDGGG--QFTTIRVYFNILDVNDNPPI 1943

Query: 280  FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLI 339
            F   SY   L EN P+G +V+     D+D G N+++ Y+      + +    +D+N G++
Sbjct: 1944 FSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ--FTVDKN-GVL 2000

Query: 340  TVQGPVDREDLSTLRFSVLAKDRGTNPKS---ARAQVVVTVKDMNDNAPTIEIRGIGLVT 396
             V   +DRE  S     V   D    P S   + AQV + + D+NDN PT          
Sbjct: 2001 KVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFL-------- 2052

Query: 397  HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
                +  I E+   +T V   Q +D D G N+ +   +   +  +    +  G       
Sbjct: 2053 -SPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGE------ 2105

Query: 457  FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516
             ++ T  LD E+V +YT+ +VA D G P LSS+  + V V+D+NDN P+F Q++ +V   
Sbjct: 2106 -VRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEIN 2164

Query: 517  ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576
            EN   G  I ++ A+D D G+N ++ Y +         F I   TG I V   LDRE+  
Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGI-VNGNTNQEFRIDSVTGAITVAKPLDREKTP 2223

Query: 577  SYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL-SPVGMVT 635
            +Y L V A DRGS     T+TV + +LD ND  P F LS Y+ +V EN+  L   +  V 
Sbjct: 2224 TYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVV 2283

Query: 636  VIDGDKGENAQVQLSVEQDNGDFVIQ-NGTGTILSSLSFDREQQSTYTFQLKAVDGGVPP 694
              D D+G N+++   +   N D     + +G +  + S DRE +  +   + A D G P 
Sbjct: 2284 ARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPA 2343

Query: 695  RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIY 754
             +    + + V D NDN P  T  S      +      G  V  V A D D+  NA  + 
Sbjct: 2344 LTGTGTINVIVDDVNDNVP--TFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA--VI 2399

Query: 755  SIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800
             I GGN    F I   +G I     ++R     + LVV  SD G P
Sbjct: 2400 RIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSP 2443



 Score =  273 bits (698), Expect = 6e-73
 Identities = 215/727 (29%), Positives = 338/727 (46%), Gaps = 56/727 (7%)

Query: 149  PRLLEGQIEV--QDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206
            PR    ++E+  QDINDN P F + ++ L + EN   GS      A D D G N + +Y 
Sbjct: 1719 PRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYT 1778

Query: 207  LQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALL 266
            + +G  A + F +      + +   LI    LDRER   Y L ++  DG    ++S   +
Sbjct: 1779 IISG--ADDSFRI------DPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRI 1827

Query: 267  RVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326
             +TV D ND+ PKF RP Y  ++ E++  G  V  + A D D G N EI Y  ++  E  
Sbjct: 1828 NITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDE-- 1885

Query: 327  RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386
              +  L+  TG+  +   +D E       +V A+D G    + R  V   + D+NDN P 
Sbjct: 1886 DGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIR--VYFNILDVNDNPPI 1943

Query: 387  IEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQAS 446
              +             ++ E++   + V +  V+D D+G N+ +T  +A           
Sbjct: 1944 FSLNSYS--------TSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD 1995

Query: 447  ETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLS---STNSLKVQVVDVNDNA 503
            + G        L+    LD E    Y + +   D    P S   ST  + + ++DVNDN 
Sbjct: 1996 KNG-------VLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNP 2048

Query: 504  PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
            P F  S      PEN     V+ +  A+D DSG N+ + Y+L      K  F+I    GE
Sbjct: 2049 PTFL-SPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK--FSIGTIDGE 2105

Query: 564  IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
            +++   LDRE+  +Y L VVA D+G PSL  +  V+V VLD NDN+P F  + Y   + E
Sbjct: 2106 VRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINE 2165

Query: 624  NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG--DFVIQNGTGTILSSLSFDREQQSTY 681
            N    + +  V   DGD+G N QV+  +   N   +F I + TG I  +   DRE+  TY
Sbjct: 2166 NTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTY 2225

Query: 682  TFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT--RLGETVSQV 739
               ++A D G  PR+    V+I +LD ND  P       + + +  P+    L  T+ QV
Sbjct: 2226 HLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFEL---SPYSVNVPENLGTLPRTILQV 2282

Query: 740  AAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGK 799
             A D D G N++L Y + GGN    F + S SG + + + ++R       L++  +D G 
Sbjct: 2283 VARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGS 2341

Query: 800  PPRYGTALVHLYVNE------TLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNI 853
            P   GT  +++ V++      T A++    T +     T  D+ +    + + SK   N 
Sbjct: 2342 PALTGTGTINVIVDDVNDNVPTFASKAYF-TTIPEDAPTGTDVLLVNASDADASK---NA 2397

Query: 854  LFGVVAG 860
            +  ++ G
Sbjct: 2398 VIRIIGG 2404



 Score =  260 bits (665), Expect = 4e-69
 Identities = 197/663 (29%), Positives = 309/663 (46%), Gaps = 31/663 (4%)

Query: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
            I V D+NDN P F        I EN +   +  +  A D+D+GPNG   YE+  G   + 
Sbjct: 2657 ITVLDVNDNAPIFKEDPFISEILENLSPRKILTVS-AMDKDSGPNGQLDYEIVNG-NMEN 2714

Query: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
             F +  A  +         +  LDRE+   Y LTIK  D GSP +++S  + + +LD ND
Sbjct: 2715 SFSINHATGEIRS------VRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDEND 2768

Query: 276  NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335
            NAP+F +  + A + ENSP+G++V +V  +D D G NA   Y+   A         ++ +
Sbjct: 2769 NAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDA----SLPFTINPS 2823

Query: 336  TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395
            TG I +  P++RED    R  V A D G    +    V + V D+NDNAP        L 
Sbjct: 2824 TGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDINDNAPRFSRTSYYL- 2879

Query: 396  THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKK 455
                   +  E     + V  V  +D DEG N  V   +     +    A+     +K+ 
Sbjct: 2880 -------DCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQI 2932

Query: 456  YFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAF 515
               Q  T      +  ++  + + D G P L S  ++ + +VD NDNAP F +S      
Sbjct: 2933 LKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPV 2992

Query: 516  PENNKPGEVIAEITA-SDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQ 574
             +N K G  +  +TA  D D G N+E+ Y +  +    G F +  +TG I V +SL  + 
Sbjct: 2993 TKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHL-GKFKLDNDTGWISVASSLISDL 3051

Query: 575  RESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMV 634
             +++ + V A D+G+P L   ATV + V + N + P+F  S  + ++ E+    S V  V
Sbjct: 3052 NQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV 3111

Query: 635  TVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGV 692
            +  D D   N  ++ S+   N  G F I + TG +  + + D E    +   + A+DGG 
Sbjct: 3112 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGW 3171

Query: 693  PPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAEL 752
              R+ Y  VT+NV+D NDN+P     S+     +      G TV  + A D DSG NA +
Sbjct: 3172 VARTGYCSVTVNVIDVNDNSPVFL--SDDYFPTVLENAPSGTTVIHLNATDADSGTNAVI 3229

Query: 753  IYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
             Y++   +   LF I  ++G IT +  ++      + L VK  +     R   A V++ +
Sbjct: 3230 AYTVQSSDS-DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQL 3288

Query: 813  NET 815
              T
Sbjct: 3289 KGT 3291



 Score =  260 bits (664), Expect = 5e-69
 Identities = 212/669 (31%), Positives = 298/669 (44%), Gaps = 47/669 (7%)

Query: 138  VSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDA 197
            V  TD  Q       E  + V DINDN P FA  +  + I ENT  G+      A+D D 
Sbjct: 2124 VVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDE 2183

Query: 198  GPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS 257
            G NG   Y +  G   QE          +     + V   LDRE+  +Y LT++  D GS
Sbjct: 2184 GTNGQVRYGIVNGNTNQEF-------RIDSVTGAITVAKPLDREKTPTYHLTVQATDRGS 2236

Query: 258  PPRASSALLRVTVLDTNDNAPKFERPSYEAELSEN-SPIGHSVIQVKANDSDQGANAEIE 316
             PR  ++ + + +LD ND  P FE   Y   + EN   +  +++QV A D D+G+N+++ 
Sbjct: 2237 TPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLS 2296

Query: 317  YTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376
            Y      E     L     +G + V   +DRE        + A D G+   +    + V 
Sbjct: 2297 YVLFGGNEDNAFTLSA---SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVI 2353

Query: 377  VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436
            V D+NDN PT   +             I ED    T V LV  SD D  +NA +  ++ G
Sbjct: 2354 VDDVNDNVPTFASKAY--------FTTIPEDAPTGTDVLLVNASDADASKNAVIR-IIGG 2404

Query: 437  DVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQ 495
            +  F +  +  TG        + T+  LD E   +YT+ +V  D+G+P PLSS+ S+ V 
Sbjct: 2405 NSQFTINPS--TGQ-------IITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVT 2455

Query: 496  VVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLF 555
            V DVNDN P F         P    PG  +  +T +DAD G N+EL YSL    + K  F
Sbjct: 2456 VTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEK--F 2513

Query: 556  TISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS 615
             I P  G I     L+     ++ + V   D GS     + TV V  ++  D  PK    
Sbjct: 2514 HIDPLRGAIMAAGPLNGASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKAD-FPKVRAK 2570

Query: 616  GYNFSVMENMPALSPVGMVTVIDGD--KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSF 673
               F   EN P  S   +VT I G   +GE     ++       F I   TG +  S   
Sbjct: 2571 EQTFMFPENQPVSS---LVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPL 2627

Query: 674  DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKL--LTPQTR 731
            D E+   Y   ++A DGG PP S+Y  + I VLD NDNAP        S  L  L+P+  
Sbjct: 2628 DFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPR-- 2685

Query: 732  LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791
                +  V+A D DSG N +L Y I  GN    F I   +G I   + ++R     + L 
Sbjct: 2686 ---KILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLT 2742

Query: 792  VKVSDRGKP 800
            +K SD+G P
Sbjct: 2743 IKSSDKGSP 2751



 Score =  259 bits (662), Expect = 9e-69
 Identities = 237/745 (31%), Positives = 342/745 (45%), Gaps = 73/745 (9%)

Query: 70   PNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPG 129
            P T++  +A D    D G   KL     Y+   G   + FT   S +  G+ +  ++   
Sbjct: 2276 PRTILQVVARD---DDRGSNSKLS----YVLFGGNEDNAFTLSASGEL-GVTQSLDRETK 2327

Query: 130  DPCILEFEVSITDLVQNGSPRLL-EGQIEV--QDINDNTPNFASPVITLAIPENTNIGSL 186
            +  +L   ++ TD   +GSP L   G I V   D+NDN P FAS      IPE+   G+ 
Sbjct: 2328 ERFVLM--ITATD---SGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTD 2382

Query: 187  FPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSY 246
              +  ASD DA  N V             + G            Q+I    LDRE  D+Y
Sbjct: 2383 VLLVNASDADASKNAVI-----------RIIGGNSQFTINPSTGQIITSALLDRETKDNY 2431

Query: 247  DLTIKVQDGGSP-PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKAN 305
             L +   D GSP P +SS  + VTV D NDN P+F+   Y   +   +  G  V  V   
Sbjct: 2432 TLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVT 2491

Query: 306  DSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTN 365
            D+D G N+E+ Y+             +D   G I   GP++    S + FSV  KD G+ 
Sbjct: 2492 DADIGPNSELHYSLSGRNS---EKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSF 2546

Query: 366  PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEG 425
            PK+    V V   +  D  P +  +       Q  M   ++ V+      +   S R E 
Sbjct: 2547 PKTDSTTVTVRFVNKAD-FPKVRAK------EQTFMFPENQPVSS-LVTTITGSSLRGEP 2598

Query: 426  ENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPP 485
             +  +     G+  FQ+ Q +   S S+         PLD+EK++ Y + I A D G PP
Sbjct: 2599 MSYYIASGNLGNT-FQIDQLTGQVSISQ---------PLDFEKIQKYVVWIEARDGGFPP 2648

Query: 486  LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545
             SS   L + V+DVNDNAP+F +        EN  P +++  ++A D DSG N +L Y +
Sbjct: 2649 FSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILT-VSAMDKDSGPNGQLDYEI 2707

Query: 546  EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605
                  +  F+I+  TGEI+    LDRE+   Y L + ++D+GSPS   +  V++N+LD 
Sbjct: 2708 -VNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDE 2766

Query: 606  NDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTG 665
            NDN P+F    ++  V EN P    V  VT  D D G NA  + S+   +  F I   TG
Sbjct: 2767 NDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTG 2825

Query: 666  TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKL 725
             I+ S   +RE    Y  ++ A D G    +    VTI V D NDNAP     S TS+ L
Sbjct: 2826 DIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRF---SRTSYYL 2879

Query: 726  LTPQ-TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRH 784
              P+ T +G  V+QV A D D G N ++ Y I   + Y  F+I + +G I   K+I +  
Sbjct: 2880 DCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEY--FRINATTGEI-FNKQILKYQ 2936

Query: 785  H---------GLHRLVVKVSDRGKP 800
            +           H  +V  SDRGKP
Sbjct: 2937 NVTGFSNVNINRHSFIVTSSDRGKP 2961



 Score =  238 bits (607), Expect = 2e-62
 Identities = 198/680 (29%), Positives = 301/680 (44%), Gaps = 53/680 (7%)

Query: 140 ITDLVQNGSPR---LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196
           + ++   G P+    L+  + VQDINDN P F S      +PE+  +GS      A+D D
Sbjct: 219 LVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADAD 278

Query: 197 AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 256
            G N    Y LQ      ++         + +   + V   LD E    Y LT++  D G
Sbjct: 279 EGTNADIRYRLQDEGTPFQM---------DPETGLITVREPLDFEARRQYSLTVQAMDRG 329

Query: 257 SPPRASSALLRVTVLDTNDNAPK-----FERPSYEAELSENSPIGHSVIQVKANDSDQ-G 310
            P     A   + +LD NDN P      F   S  A + EN+ +G  V  +   D+D   
Sbjct: 330 VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPA 389

Query: 311 ANAEIEYTFHQAPEVVRRLLRLDR--NTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-- 366
           AN  I        E     ++  +  N  LI V   +DRE + +   +V   D    P  
Sbjct: 390 ANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPG 449

Query: 367 -----KSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSD 421
                +S+ A +V+ V D+ND+ P          + Q    N+SE+    + V+ +  +D
Sbjct: 450 AAVQARSSVASLVIFVNDINDHPPVF--------SQQVYRVNLSEEAPPGSYVSGISATD 501

Query: 422 RDEGENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTTP---LDYEKVKDYTIEIV 477
            D G NA +   +V+G+       +  +G        L TT     LD E      + I 
Sbjct: 502 GDSGLNANLRYSIVSGNGLGWFHISEHSG--------LVTTGSSGGLDRELASQIVLNIS 553

Query: 478 AVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT-EVAFPENNKPGEVIAEITASDADSG 536
           A D G  P  S   L V ++DVND  PVF+Q    +V+  EN   G  +  + A+D D G
Sbjct: 554 ARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLG 613

Query: 537 SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
            N  + +SL+     +  F + P +G +   +SLDRE++  Y L V+A D GSP     A
Sbjct: 614 DNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMA 673

Query: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQ-DN 655
            + V++LD NDN P F    Y   + EN P  S +  V+  D D G N  V+ S+   D 
Sbjct: 674 RINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR 733

Query: 656 GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYI 715
             F +   +G I + ++ DRE+++ Y  Q+ A DGG         VTI VLD  DN P  
Sbjct: 734 SRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVF 793

Query: 716 TAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAIT 775
           +  + +   ++     LG  V  V+A   D  +N+ + Y I  G+  G+F I   +G +T
Sbjct: 794 SQVAYSF--VVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLT 849

Query: 776 LEKEIERRHHGLHRLVVKVS 795
               I+R     ++L V  S
Sbjct: 850 TANVIDREEQSFYQLKVVAS 869



 Score =  236 bits (601), Expect = 1e-61
 Identities = 201/691 (29%), Positives = 313/691 (45%), Gaps = 46/691 (6%)

Query: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE--- 212
            I V DINDN P F+     L  PE T IGS      A+D D G NG   Y +++  E   
Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFR 2919

Query: 213  ----AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
                  E+F  Q+ + Q      +    N++  R   +   +   D G P   S   + +
Sbjct: 2920 INATTGEIFNKQILKYQN-----VTGFSNVNINR---HSFIVTSSDRGKPSLISETTVTI 2971

Query: 269  TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA-NDSDQGANAEIEYTFHQAPEVVR 327
             ++D+NDNAP+F +  Y   +++N  +G  +I+V A +D D G N+E+EY       + +
Sbjct: 2972 NIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031

Query: 328  RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387
               +LD +TG I+V   +  +       +V AKD+G  P S++A V +TV + N + P  
Sbjct: 3032 --FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEF 3089

Query: 388  EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447
                    +H    A I E  +  + V  V   DRD   N        G + + +   +E
Sbjct: 3090 S------QSHMS--ATIPESHSIGSIVRTVSARDRDAAMN--------GLIKYSISSGNE 3133

Query: 448  TG--SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505
             G  + +     L     LDYE  + + + I A+D G    +   S+ V V+DVNDN+PV
Sbjct: 3134 EGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPV 3193

Query: 506  FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ 565
            F          EN   G  +  + A+DADSG+NA + Y+++   +   LF I P TG I 
Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS--DLFVIDPNTGVIT 3251

Query: 566  VKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENM 625
             +  LD E ++SY L V A +         ATV + +   N+  P+F+   Y F + E  
Sbjct: 3252 TQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAA 3311

Query: 626  PALSPVGMVTVIDGDKGENAQVQLSV--EQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683
            P  + VG V   D D G + +V   +        F I   TG I  S   DRE++   + 
Sbjct: 3312 PKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSL 3371

Query: 684  QLKAVDGGVPPRSAYVGVTINV--LDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAA 741
            ++ A + G    +    VT+NV  LD ND  P  T   N     ++    +G  V+ V+A
Sbjct: 3372 KVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTL--NIYSVQISEGVPIGTHVTFVSA 3428

Query: 742  EDFDSGVN-AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800
             D DS  + +   Y I  GN  G F I   +G IT+  E++R    ++ L V   D G P
Sbjct: 3429 FDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTP 3488

Query: 801  PRYGTALVHLYVNETLANRTLLETLLGHSLD 831
               G+A + + + +   N  +L    G  ++
Sbjct: 3489 SATGSASLLVTLEDINDNGPMLTVSEGEVME 3519



 Score =  233 bits (593), Expect = 9e-61
 Identities = 182/675 (26%), Positives = 306/675 (45%), Gaps = 54/675 (8%)

Query: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
            I + D NDN P F S + +  +PEN+ +G        SD D G N ++ Y +    +A  
Sbjct: 2761 INILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM---DASL 2816

Query: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
             F +  +         +++   L+RE  D Y + +   D G      S  + + V D ND
Sbjct: 2817 PFTINPSTGD------IVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDIND 2867

Query: 276  NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVR-------- 327
            NAP+F R SY  +  E + IG  V QV A D D+G+N ++ Y      E  R        
Sbjct: 2868 NAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEI 2927

Query: 328  ---RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNA 384
               ++L+    TG   V       +++   F V + DRG     +   V + + D NDNA
Sbjct: 2928 FNKQILKYQNVTGFSNV-------NINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2980

Query: 385  PTIEIRGIGLVTHQDGMANISEDVAEETA-VALVQVSDRDEGENAAVTCVVAGDVPF-QL 442
            P                  ++++V   T  + +  + D+D G N+ V   ++ D    + 
Sbjct: 2981 PQF--------LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKF 3032

Query: 443  RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
            +  ++TG       ++   + L  +  +++ I + A D GNPPLSS  ++ + V + N +
Sbjct: 3033 KLDNDTG-------WISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYH 3085

Query: 503  APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
             P F+QS      PE++  G ++  ++A D D+  N  + YS+      +G+F I+  TG
Sbjct: 3086 TPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS-SGNEEGIFAINSSTG 3144

Query: 563  EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVM 622
             + +  +LD E  + +E+ + A D G  +  G  +V VNV+D NDN P F+   Y  +V+
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204

Query: 623  ENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTY 681
            EN P+ + V  +   D D G NA +  +V+  + D FVI   TG I +    D E + +Y
Sbjct: 3205 ENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSY 3264

Query: 682  TFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAA 741
               +KA +     R ++  V I +   N+  P     S   +  ++     G  V +V A
Sbjct: 3265 HLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFV--SKLYYFEISEAAPKGTIVGEVFA 3322

Query: 742  EDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPP 801
             D D G + E+ Y I G +    FQI   +G I +   ++R      R+ +KV  +    
Sbjct: 3323 SDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKE--ERVSLKVLAKNFGS 3380

Query: 802  RYGTALVHLYVNETL 816
              G  +  + VN T+
Sbjct: 3381 IRGADIDEVTVNVTV 3395



 Score =  224 bits (570), Expect = 4e-58
 Identities = 219/771 (28%), Positives = 334/771 (43%), Gaps = 92/771 (11%)

Query: 70   PNTLIGS-----LAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQ 124
            P+ +IGS     +AAD   PD G   ++E    Y  ++G T        S D   LR   
Sbjct: 1539 PSAVIGSVLTTIMAAD---PDEGANGEIE----YEIINGDTDTFIVDRYSGD---LRVAS 1588

Query: 125  NQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
              +P    I    VS TDL         E  I +Q ++   P F  P     + E   IG
Sbjct: 1589 ALVPSQ-LIYNLIVSATDLGPERRKSTTELTIILQGLDG--PVFTQPKYITILKEGEPIG 1645

Query: 185  S-LFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGN------ 237
            + +  I  AS R              G EA   + +     +E+   +L  +G       
Sbjct: 1646 TNVISIEAASPR--------------GSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQ 1691

Query: 238  ----LDRERWDSYDLT--IKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSE 291
                LDRE+     L     ++   + PR   A + +T+ D NDN P F     +  + E
Sbjct: 1692 TAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEE 1751

Query: 292  NSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLS 351
            N   G  ++Q+ A D+D+GANA + YT     +      R+D  +G +     +DRE  S
Sbjct: 1752 NIGDGSKIMQLTAMDADEGANALVTYTIISGAD---DSFRIDPESGDLIATRRLDRERRS 1808

Query: 352  TLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEE 411
                 V A D     +S+  ++ +TV D+ND+ P                 +I ED    
Sbjct: 1809 KYSLLVRADD---GLQSSDMRINITVSDVNDHTPKFSRPVYSF--------DIPEDTIPG 1857

Query: 412  TAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP-------L 464
            + VA +  +D D G N  +T +V  D             D    +FL   T        L
Sbjct: 1858 SLVAAILATDDDSGVNGEITYIVNED-------------DEDGIFFLNPITGVFNLTRLL 1904

Query: 465  DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEV 524
            DYE  + Y + + A D G     +T  +   ++DVNDN P+F+ +    +  EN   G  
Sbjct: 1905 DYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGST 1962

Query: 525  IAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584
            +     +DAD G N++L YS+    +  G FT+  + G ++V  +LDRE +  Y L V  
Sbjct: 1963 VLVFNVTDADDGINSQLTYSIASGDSL-GQFTVD-KNGVLKVLKALDRESQSFYNLVVQV 2020

Query: 585  ADRGS-PSLQGTATVLVNV--LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDK 641
             D    P+ + T+T  V++  LD NDN P F+     + + EN P  + V      D D 
Sbjct: 2021 HDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDS 2079

Query: 642  GENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG 700
            G N+ ++ ++    G+ F I    G +  +   DRE+ S YT  + A D G P  S+   
Sbjct: 2080 GPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTE 2139

Query: 701  VTINVLDENDNAPYITAPSNTSHKL-LTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
            V + VLD NDN P     +   +K+ +   T  G  + QV A D D G N ++ Y I  G
Sbjct: 2140 VVVMVLDINDNNPIF---AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNG 2196

Query: 760  NPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHL 810
            N    F+I S +GAIT+ K ++R     + L V+ +DRG  PR  T+ V +
Sbjct: 2197 NTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247



 Score =  213 bits (542), Expect = 8e-55
 Identities = 192/745 (25%), Positives = 306/745 (41%), Gaps = 55/745 (7%)

Query: 84   PDVGH----LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVS 139
            PD G      Y ++  + Y R++  TG+IF  +       + + QN        +     
Sbjct: 2899 PDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQ-------ILKYQNVTGFSNVNINRHSF 2951

Query: 140  ITDLVQNGSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGS-LFPIPLASDR 195
            I      G P L+      I + D NDN P F        + +N  +G+ L  +    D+
Sbjct: 2952 IVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDK 3011

Query: 196  DAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDG 255
            D G N    Y +        L   ++  D       + V  +L  +   ++ +T+  +D 
Sbjct: 3012 DFGLNSEVEYFIS---NDNHLGKFKLDNDTG----WISVASSLISDLNQNFFITVTAKDK 3064

Query: 256  GSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEI 315
            G+PP +S A + +TV + N + P+F +    A + E+  IG  V  V A D D   N  I
Sbjct: 3065 GNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLI 3124

Query: 316  EYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVV 375
            +Y+     E    +  ++ +TG++T+   +D E       ++ A D G   ++    V V
Sbjct: 3125 KYSISSGNE--EGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTV 3182

Query: 376  TVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVA 435
             V D+NDN+P             D    + E+    T V  +  +D D G NA +   V 
Sbjct: 3183 NVIDVNDNSPVF--------LSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQ 3234

Query: 436  GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQ 495
                        TG        + T   LD+E  + Y + + A +  +    S  ++ +Q
Sbjct: 3235 SSDSDLFVIDPNTG-------VITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQ 3287

Query: 496  VVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLF 555
            +   N+  P F   +      E    G ++ E+ ASD D G++ E+ Y +      KG F
Sbjct: 3288 LKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG-F 3346

Query: 556  TISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGT----ATVLVNVLDCNDNDPK 611
             I+ +TG+I V   LDRE+ E   LKV+A + GS  ++G      TV V VLD ND  P 
Sbjct: 3347 QINKKTGQIYVSGILDREKEERVSLKVLAKNFGS--IRGADIDEVTVNVTVLDAND-PPI 3403

Query: 612  FMLSGYNFSVMENMPALSPVGMVTVIDGDK---GENAQVQLSVEQDNGDFVIQNGTGTIL 668
            F L+ Y+  + E +P  + V  V+  D D           +    +NG F I   TG I 
Sbjct: 3404 FTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQIT 3463

Query: 669  SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728
             +   DRE    Y   + AVD G P  +    + + + D NDN P +T     S   +  
Sbjct: 3464 VTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLT----VSEGEVME 3519

Query: 729  QTRLGETVSQVAAEDFDSGVN-AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGL 787
              R G  V  + + D D   N     Y +    P   +   S +G ++  +EI+R     
Sbjct: 3520 NKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIAD 3579

Query: 788  HRLVVKVSDRGKPPRYGTALVHLYV 812
              L V   D G P    T  VH+ V
Sbjct: 3580 FYLSVVTKDSGVPQMSSTGTVHITV 3604



 Score =  209 bits (532), Expect = 1e-53
 Identities = 173/565 (30%), Positives = 270/565 (47%), Gaps = 40/565 (7%)

Query: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
            I V + N +TP F+   ++  IPE+ +IGS+     A DRDA  NG+  Y + +G E + 
Sbjct: 3077 ITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNE-EG 3135

Query: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
            +F +  +         L +   LD E    +++TI   DGG   R     + V V+D ND
Sbjct: 3136 IFAINSSTGI------LTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVND 3189

Query: 276  NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335
            N+P F    Y   + EN+P G +VI + A D+D G NA I YT   +      L  +D N
Sbjct: 3190 NSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS---DLFVIDPN 3246

Query: 336  TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395
            TG+IT QG +D E   +   +V A +     + + A V + +K  N+  P    R +  +
Sbjct: 3247 TGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVP----RFVSKL 3302

Query: 396  THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVP---FQLRQASETGSDS 452
             + +    ISE   + T V  V  SDRD G +  V  ++ G+     FQ+         +
Sbjct: 3303 YYFE----ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI---------N 3349

Query: 453  KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN--SLKVQVVDVNDNAPVFTQSV 510
            KK   +  +  LD EK +  +++++A + G+   +  +  ++ V V+D ND  P+FT ++
Sbjct: 3350 KKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNI 3408

Query: 511  TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570
              V   E    G  +  ++A D+DS  +              G F+I+P+TG+I V   L
Sbjct: 3409 YSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAEL 3468

Query: 571  DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630
            DRE    Y L V+A D G+PS  G+A++LV + D NDN P  ML+     VMEN    + 
Sbjct: 3469 DRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP--MLTVSEGEVMENKRPGTL 3526

Query: 631  VGMVTVIDGD----KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLK 686
            V  +   D D    +G      LS       F +    G + ++   DREQ + +   + 
Sbjct: 3527 VMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVV 3585

Query: 687  AVDGGVPPRSAYVGVTINVLDENDN 711
              D GVP  S+   V I V+D+NDN
Sbjct: 3586 TKDSGVPQMSSTGTVHITVIDQNDN 3610


>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 1007

 Score =  342 bits (878), Expect = 8e-94
 Identities = 240/693 (34%), Positives = 359/693 (51%), Gaps = 56/693 (8%)

Query: 37  LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFP----DVGHLYKL 92
           LLLP  LL LLLLL P P  A+++ Y VPEEQ P  L+G++A   G        G L   
Sbjct: 24  LLLP--LLLLLLLLLPGPA-ASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRIN 80

Query: 93  EVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSP 149
            +GAP   YL +D  +G +F  E  IDRE L E + +     C+L  EV   + V   + 
Sbjct: 81  HLGAPSPRYLELDLTSGALFVNER-IDREALCEQRPR-----CLLSLEVLAHNPVAVSAV 134

Query: 150 RLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA 209
                ++E+ DINDN+P F  P   L + E+   G+ F I  A D D G N V +YEL  
Sbjct: 135 -----EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSP 189

Query: 210 GPEAQELFGLQVAEDQEE-KQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
                E F L +   QE  K  +L++   LDRE+   + L +   DGG P R+ +A + V
Sbjct: 190 S----EHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISV 245

Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVR 327
            VLDTNDN+P F++ +Y  +L E+SP G  V+++ A+D D+G+N E+ Y+      +  R
Sbjct: 246 RVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRER 305

Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387
           +L  +D +TG + V G +D E+ S+ +  V A DRG  P +   +V+V + D+NDNAP +
Sbjct: 306 QLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEV 365

Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447
            +         D  + + E+    T VA++ V+D+D G N  V+  +   +PF+L     
Sbjct: 366 VL--------TDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGN 417

Query: 448 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507
           +       Y L  + PLD E+V  Y I + A D G P L+S  +LKV++ D+NDN P F 
Sbjct: 418 S-------YTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL 470

Query: 508 QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL-----FTISPETG 562
           +    +   ENN PG ++  + A+D D   NAE+ YSL  E   +GL      +I+  +G
Sbjct: 471 EDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSL-LEREIQGLPVTSYVSINSASG 529

Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM--LSGYNFS 620
            +    S D E+   + + V A D+GSP L  T T  V V+D ND+ P  +   S  + +
Sbjct: 530 SLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSA 589

Query: 621 VMENMPALSPVG----MVTVIDGDKGENAQV--QLSVEQDNGDFVIQNGTGTILSSLSFD 674
             E +P  +P G     V  +D D G+NA +   L+   D   F ++  TG I ++    
Sbjct: 590 AFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMG 649

Query: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
            E  ST+   +   D G P  SA V +T+ V+D
Sbjct: 650 DESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682



 Score =  224 bits (570), Expect = 4e-58
 Identities = 172/563 (30%), Positives = 264/563 (46%), Gaps = 43/563 (7%)

Query: 259 PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYT 318
           P A SA+  V +LD NDN+P+F RP+Y+ ++SE+   G       A D D GAN+   Y 
Sbjct: 128 PVAVSAV-EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYE 186

Query: 319 FHQAPEVVRRLLRLDRNTGLI--TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376
              +      L  L  N+ ++   ++  +DRE  +     + A D G   +S  AQ+ V 
Sbjct: 187 LSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVR 246

Query: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436
           V D NDN+P  +               + ED    T V  +  SD DEG N        G
Sbjct: 247 VLDTNDNSPAFD--------QSTYRVQLREDSPPGTLVVKLNASDPDEGSN--------G 290

Query: 437 DVPFQLRQASETGSDSKKKYFLQTTTP-------LDYEKVKDYTIEIVAVDSGNPPLSST 489
           ++ + L  +S T    ++ + +  +T        LDYE+   Y I + A D G  P++  
Sbjct: 291 ELRYSL--SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348

Query: 490 NSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE- 548
             + V +VDVNDNAP    +      PEN  P  ++A ++ +D DSG N ++   LE   
Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408

Query: 549 PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDN 608
           P     F  S     + V   LDRE+   Y + V A D G P L    T+ V + D NDN
Sbjct: 409 PFRLNGFGNSYT---LVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDN 465

Query: 609 DPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQ 661
            P F+   Y+  + EN      +  V   D D+ ENA+V  S+ +     +       I 
Sbjct: 466 PPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSIN 525

Query: 662 NGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNT 721
           + +G++ +  SFD E+   +   ++A D G PP S+ V   + V+D ND+AP+I  P++T
Sbjct: 526 SASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585

Query: 722 SHKL---LTPQTR-LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777
           +      + P+T   G  V++V A D DSG NA L Y +A  +   LF++  H+G I   
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTT 645

Query: 778 KEIERRHHGLHRLVVKVSDRGKP 800
           +++         L V V D G+P
Sbjct: 646 RKMGDESGSTFNLTVVVRDNGEP 668



 Score =  200 bits (508), Expect = 7e-51
 Identities = 158/502 (31%), Positives = 235/502 (46%), Gaps = 37/502 (7%)

Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLR------FSVLAKDRGTNPKSARAQVVVTVKDMN 381
           R L LD  +G + V   +DRE L   R        VLA     NP +  A V V + D+N
Sbjct: 88  RYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAH----NPVAVSA-VEVEILDIN 142

Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441
           DN+P        L         +SE VA      +    D D G N+  T  ++    F+
Sbjct: 143 DNSPRFPRPNYQL--------QVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFE 194

Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
           L    +   ++ K   L     LD E+   + + + AVD G P  S T  + V+V+D ND
Sbjct: 195 LDL--KPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTND 252

Query: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA--AKGLFTISP 559
           N+P F QS   V   E++ PG ++ ++ ASD D GSN EL YSL    +   + LF+I  
Sbjct: 253 NSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDA 312

Query: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
            TGE++V   LD E+  SY++ V A DRG   + G   VLV+++D NDN P+ +L+    
Sbjct: 313 STGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYS 372

Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTG---TILSSLSFDRE 676
            V EN    + V +++V D D G N +V L +E      +  NG G   T++ S   DRE
Sbjct: 373 PVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRL--NGFGNSYTLVVSGPLDRE 430

Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GET 735
           + + Y   + A DGG+P  ++   + + + D NDN P        S+ +   +  L G  
Sbjct: 431 RVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL---EDSYSIYIQENNLPGVL 487

Query: 736 VSQVAAEDFDSGVNAELIYSIAGGNPYGL-----FQIGSHSGAITLEKEIERRHHGLHRL 790
           +  V A D D   NAE+ YS+      GL       I S SG++      +        +
Sbjct: 488 LCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFV 547

Query: 791 VVKVSDRGKPPRYGTALVHLYV 812
            V+  D+G PP   T   ++YV
Sbjct: 548 TVEAQDKGSPPLSSTVTANVYV 569



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 18/132 (13%)

Query: 697 AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA------AEDFDSGVNA 750
           A   V + +LD NDN+P    P+         Q ++ E+V+  A      A+D D G N+
Sbjct: 130 AVSAVEVEILDINDNSPRFPRPNY--------QLQVSESVAPGARFHIESAQDPDVGANS 181

Query: 751 ELIYSIAGGNPYGL----FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTA 806
              Y ++    + L     Q  S    + L K ++R    LH LV+   D G P R GTA
Sbjct: 182 VQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTA 241

Query: 807 LVHLYVNETLAN 818
            + + V +T  N
Sbjct: 242 QISVRVLDTNDN 253


>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 884

 Score =  342 bits (878), Expect = 8e-94
 Identities = 240/693 (34%), Positives = 359/693 (51%), Gaps = 56/693 (8%)

Query: 37  LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFP----DVGHLYKL 92
           LLLP  LL LLLLL P P  A+++ Y VPEEQ P  L+G++A   G        G L   
Sbjct: 24  LLLP--LLLLLLLLLPGPA-ASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRIN 80

Query: 93  EVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSP 149
            +GAP   YL +D  +G +F  E  IDRE L E + +     C+L  EV   + V   + 
Sbjct: 81  HLGAPSPRYLELDLTSGALFVNER-IDREALCEQRPR-----CLLSLEVLAHNPVAVSAV 134

Query: 150 RLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA 209
                ++E+ DINDN+P F  P   L + E+   G+ F I  A D D G N V +YEL  
Sbjct: 135 -----EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSP 189

Query: 210 GPEAQELFGLQVAEDQEE-KQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
                E F L +   QE  K  +L++   LDRE+   + L +   DGG P R+ +A + V
Sbjct: 190 S----EHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISV 245

Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVR 327
            VLDTNDN+P F++ +Y  +L E+SP G  V+++ A+D D+G+N E+ Y+      +  R
Sbjct: 246 RVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRER 305

Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387
           +L  +D +TG + V G +D E+ S+ +  V A DRG  P +   +V+V + D+NDNAP +
Sbjct: 306 QLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEV 365

Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447
            +         D  + + E+    T VA++ V+D+D G N  V+  +   +PF+L     
Sbjct: 366 VL--------TDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGN 417

Query: 448 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507
           +       Y L  + PLD E+V  Y I + A D G P L+S  +LKV++ D+NDN P F 
Sbjct: 418 S-------YTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL 470

Query: 508 QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL-----FTISPETG 562
           +    +   ENN PG ++  + A+D D   NAE+ YSL  E   +GL      +I+  +G
Sbjct: 471 EDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSL-LEREIQGLPVTSYVSINSASG 529

Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM--LSGYNFS 620
            +    S D E+   + + V A D+GSP L  T T  V V+D ND+ P  +   S  + +
Sbjct: 530 SLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSA 589

Query: 621 VMENMPALSPVG----MVTVIDGDKGENAQV--QLSVEQDNGDFVIQNGTGTILSSLSFD 674
             E +P  +P G     V  +D D G+NA +   L+   D   F ++  TG I ++    
Sbjct: 590 AFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMG 649

Query: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
            E  ST+   +   D G P  SA V +T+ V+D
Sbjct: 650 DESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682



 Score =  224 bits (570), Expect = 4e-58
 Identities = 172/563 (30%), Positives = 264/563 (46%), Gaps = 43/563 (7%)

Query: 259 PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYT 318
           P A SA+  V +LD NDN+P+F RP+Y+ ++SE+   G       A D D GAN+   Y 
Sbjct: 128 PVAVSAV-EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYE 186

Query: 319 FHQAPEVVRRLLRLDRNTGLI--TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376
              +      L  L  N+ ++   ++  +DRE  +     + A D G   +S  AQ+ V 
Sbjct: 187 LSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVR 246

Query: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436
           V D NDN+P  +               + ED    T V  +  SD DEG N        G
Sbjct: 247 VLDTNDNSPAFD--------QSTYRVQLREDSPPGTLVVKLNASDPDEGSN--------G 290

Query: 437 DVPFQLRQASETGSDSKKKYFLQTTTP-------LDYEKVKDYTIEIVAVDSGNPPLSST 489
           ++ + L  +S T    ++ + +  +T        LDYE+   Y I + A D G  P++  
Sbjct: 291 ELRYSL--SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348

Query: 490 NSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE- 548
             + V +VDVNDNAP    +      PEN  P  ++A ++ +D DSG N ++   LE   
Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408

Query: 549 PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDN 608
           P     F  S     + V   LDRE+   Y + V A D G P L    T+ V + D NDN
Sbjct: 409 PFRLNGFGNSYT---LVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDN 465

Query: 609 DPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQ 661
            P F+   Y+  + EN      +  V   D D+ ENA+V  S+ +     +       I 
Sbjct: 466 PPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSIN 525

Query: 662 NGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNT 721
           + +G++ +  SFD E+   +   ++A D G PP S+ V   + V+D ND+AP+I  P++T
Sbjct: 526 SASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585

Query: 722 SHKL---LTPQTR-LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777
           +      + P+T   G  V++V A D DSG NA L Y +A  +   LF++  H+G I   
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTT 645

Query: 778 KEIERRHHGLHRLVVKVSDRGKP 800
           +++         L V V D G+P
Sbjct: 646 RKMGDESGSTFNLTVVVRDNGEP 668



 Score =  200 bits (508), Expect = 7e-51
 Identities = 158/502 (31%), Positives = 235/502 (46%), Gaps = 37/502 (7%)

Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLR------FSVLAKDRGTNPKSARAQVVVTVKDMN 381
           R L LD  +G + V   +DRE L   R        VLA     NP +  A V V + D+N
Sbjct: 88  RYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAH----NPVAVSA-VEVEILDIN 142

Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441
           DN+P        L         +SE VA      +    D D G N+  T  ++    F+
Sbjct: 143 DNSPRFPRPNYQL--------QVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFE 194

Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
           L    +   ++ K   L     LD E+   + + + AVD G P  S T  + V+V+D ND
Sbjct: 195 LDL--KPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTND 252

Query: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA--AKGLFTISP 559
           N+P F QS   V   E++ PG ++ ++ ASD D GSN EL YSL    +   + LF+I  
Sbjct: 253 NSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDA 312

Query: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
            TGE++V   LD E+  SY++ V A DRG   + G   VLV+++D NDN P+ +L+    
Sbjct: 313 STGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYS 372

Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTG---TILSSLSFDRE 676
            V EN    + V +++V D D G N +V L +E      +  NG G   T++ S   DRE
Sbjct: 373 PVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRL--NGFGNSYTLVVSGPLDRE 430

Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GET 735
           + + Y   + A DGG+P  ++   + + + D NDN P        S+ +   +  L G  
Sbjct: 431 RVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL---EDSYSIYIQENNLPGVL 487

Query: 736 VSQVAAEDFDSGVNAELIYSIAGGNPYGL-----FQIGSHSGAITLEKEIERRHHGLHRL 790
           +  V A D D   NAE+ YS+      GL       I S SG++      +        +
Sbjct: 488 LCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFV 547

Query: 791 VVKVSDRGKPPRYGTALVHLYV 812
            V+  D+G PP   T   ++YV
Sbjct: 548 TVEAQDKGSPPLSSTVTANVYV 569



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 18/132 (13%)

Query: 697 AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA------AEDFDSGVNA 750
           A   V + +LD NDN+P    P+         Q ++ E+V+  A      A+D D G N+
Sbjct: 130 AVSAVEVEILDINDNSPRFPRPNY--------QLQVSESVAPGARFHIESAQDPDVGANS 181

Query: 751 ELIYSIAGGNPYGL----FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTA 806
              Y ++    + L     Q  S    + L K ++R    LH LV+   D G P R GTA
Sbjct: 182 VQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTA 241

Query: 807 LVHLYVNETLAN 818
            + + V +T  N
Sbjct: 242 QISVRVLDTNDN 253


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  340 bits (872), Expect = 4e-93
 Identities = 252/709 (35%), Positives = 359/709 (50%), Gaps = 73/709 (10%)

Query: 42  MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDV-----GHLYKLEVGA 96
           ++L L  LL    G  +++ Y V EEQ   T +G++A D G         G         
Sbjct: 2   IVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRT 61

Query: 97  PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156
           PYL ++ +TG ++  E  IDRE +  C+ Q P   C+L  EV + + ++     L + +I
Sbjct: 62  PYLDLNLETGVLYVNE-KIDREQI--CK-QSPS--CVLHLEVFLENPLE-----LFQVEI 110

Query: 157 EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQEL 216
           EV DINDN P+F  P +T+ I E+   G+ FP+  A D D G N +  YE+         
Sbjct: 111 EVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN----SY 166

Query: 217 FGLQV-AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS----------------PP 259
           F L V  +    +  +L++   LDRE+   +   +   DGG                 PP
Sbjct: 167 FSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPP 226

Query: 260 ---RASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIE 316
              R  +ALL + VLD+NDN P F++P Y   L ENSP G  VIQ+ A D D+G N E+ 
Sbjct: 227 QQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVV 286

Query: 317 YTF--HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374
           Y+F  H +P   R L  L   TG + V G +D E+    +  V AKD G N   A  +V+
Sbjct: 287 YSFSSHISPRA-RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345

Query: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVV 434
           V V D NDNAP I    +           +SE  A  T VAL  V+DRD  EN  V C +
Sbjct: 346 VRVLDANDNAPEISFSTV--------KEAVSEGAAPGTVVALFSVTDRDSEENGQVQCEL 397

Query: 435 AGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKV 494
            GDVPF+L+      S  K  Y + T  PLD E    YT+ +VA D G P LS++ S++V
Sbjct: 398 LGDVPFRLK------SSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQV 451

Query: 495 QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYS-LEPEPAAKG 553
           QV DVNDNAP F+Q V +V   ENN PG  I  ++A+D D G+NA+L YS LE +     
Sbjct: 452 QVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMS 511

Query: 554 LFT---ISPETGEIQVKTSLDREQRESYELKVVAADRGSP-SLQGTATVLVNVLDCNDND 609
           +FT   I+ E G +    S D EQ + +  +V A D GSP +L G ATV + ++D NDN 
Sbjct: 512 VFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNA 571

Query: 610 PKFM--LSGYNFS-VMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQDN--GDFVI 660
           P  +  L G N +   E +P  +  G     V  +D D GENA++  S+ + N    F +
Sbjct: 572 PAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRM 631

Query: 661 QNGTGTILSS--LSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
              TG + ++  +   R+ Q  Y   ++  D G PP S+   + + ++D
Sbjct: 632 DWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  211 bits (536), Expect = 4e-54
 Identities = 192/676 (28%), Positives = 296/676 (43%), Gaps = 96/676 (14%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           + + VLD NDN P F  P    E+SE++  G       A D D G N+  +Y        
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-----T 162

Query: 326 VRRLLRLDRNT-------GLITVQGPVDREDLSTLRFSVLAKDRG--------------- 363
                 LD  T         + ++ P+DRE  +  R+ + A D G               
Sbjct: 163 PNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222

Query: 364 ----TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQV 419
                  ++  A + + V D NDN P  +              ++ E+    T V  +  
Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFD--------QPVYTVSLPENSPPGTLVIQLNA 274

Query: 420 SDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 479
           +D DEG+N  V    +  +     +A E    S +   L+ +  LDYE+   Y + + A 
Sbjct: 275 TDPDEGQNGEVVYSFSSHIS---PRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAK 331

Query: 480 DSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNA 539
           D G   + +   + V+V+D NDNAP  + S  + A  E   PG V+A  + +D DS  N 
Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391

Query: 540 ELVYSL------EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
           ++   L        + + K  +TI  E         LDRE  +SY L VVA DRG P+L 
Sbjct: 392 QVQCELLGDVPFRLKSSFKNYYTIVTEA-------PLDREAGDSYTLTVVARDRGEPALS 444

Query: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVE- 652
            + ++ V V D NDN P+F    Y+  V EN    + +  V+  D D+G NAQ+  S+  
Sbjct: 445 TSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILE 504

Query: 653 -QDNGDFV-----IQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVL 706
            Q  G  V     I +  G + +  SFD EQ   ++FQ++A D G P   A    T+N+L
Sbjct: 505 CQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAG-NATVNIL 563

Query: 707 --DENDNAPYITAP-----SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
             D+NDNAP I AP        + ++L      G  +++VAA D D G NA L YSI  G
Sbjct: 564 IVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRG 623

Query: 760 NPYGLFQIGSHSGAITLEKEI--ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLA 817
           N   LF++   +G +   + +  +R     + LV++V D G+PP   TA           
Sbjct: 624 NEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTA----------- 672

Query: 818 NRTLLETLLGHSLDTP--LDIDIAGDPEYERSKQRG--------NILFGVVAGVVAVALL 867
             TL+  L+  +++          G  E++R  + G         ++  +  G V+   L
Sbjct: 673 --TLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFL 730

Query: 868 IALAVLVRYCRQREAK 883
           +A+ VL   C Q+E K
Sbjct: 731 LAMIVLAVRC-QKEKK 745



 Score =  184 bits (466), Expect = 5e-46
 Identities = 157/525 (29%), Positives = 226/525 (43%), Gaps = 44/525 (8%)

Query: 319 FHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS-VLAKDRGTNPKSARAQVVVTV 377
           F   P      L L+  TG++ V   +DRE +     S VL  +          QV + V
Sbjct: 53  FQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEV 112

Query: 378 KDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGD 437
            D+NDN P+            D    ISE     T   L    D D G N+     +  +
Sbjct: 113 LDINDNPPSFP--------EPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN 164

Query: 438 VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGN-------------- 483
             F L    +T  D  +   L    PLD E+   +   + AVD G               
Sbjct: 165 SYFSLDV--QTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222

Query: 484 --PPL---SSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538
             PP    + T  L ++V+D NDN P F Q V  V+ PEN+ PG ++ ++ A+D D G N
Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQN 282

Query: 539 AELVYSLEPE--PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
            E+VYS      P A+ LF +SP TG ++V   LD E+   Y++ V A D G  ++    
Sbjct: 283 GEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHC 342

Query: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG 656
            VLV VLD NDN P+   S    +V E     + V + +V D D  EN QVQ  +  D  
Sbjct: 343 KVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV- 401

Query: 657 DFVIQNGTG---TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713
            F +++      TI++    DRE   +YT  + A D G P  S    + + V D NDNAP
Sbjct: 402 PFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAP 461

Query: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS-----IAGGNPYGLFQIG 768
             + P    +  +T     G  +  V+A D D G NA+L YS     I G + +    I 
Sbjct: 462 RFSQPVYDVY--VTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSIN 519

Query: 769 SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRY-GTALVHLYV 812
           S +G +   +  +          V+  D G P    G A V++ +
Sbjct: 520 SENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILI 564


>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
          Length = 896

 Score =  340 bits (872), Expect = 4e-93
 Identities = 252/709 (35%), Positives = 359/709 (50%), Gaps = 73/709 (10%)

Query: 42  MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDV-----GHLYKLEVGA 96
           ++L L  LL    G  +++ Y V EEQ   T +G++A D G         G         
Sbjct: 2   IVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRT 61

Query: 97  PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156
           PYL ++ +TG ++  E  IDRE +  C+ Q P   C+L  EV + + ++     L + +I
Sbjct: 62  PYLDLNLETGVLYVNE-KIDREQI--CK-QSPS--CVLHLEVFLENPLE-----LFQVEI 110

Query: 157 EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQEL 216
           EV DINDN P+F  P +T+ I E+   G+ FP+  A D D G N +  YE+         
Sbjct: 111 EVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN----SY 166

Query: 217 FGLQV-AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS----------------PP 259
           F L V  +    +  +L++   LDRE+   +   +   DGG                 PP
Sbjct: 167 FSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPP 226

Query: 260 ---RASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIE 316
              R  +ALL + VLD+NDN P F++P Y   L ENSP G  VIQ+ A D D+G N E+ 
Sbjct: 227 QQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVV 286

Query: 317 YTF--HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374
           Y+F  H +P   R L  L   TG + V G +D E+    +  V AKD G N   A  +V+
Sbjct: 287 YSFSSHISPRA-RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345

Query: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVV 434
           V V D NDNAP I    +           +SE  A  T VAL  V+DRD  EN  V C +
Sbjct: 346 VRVLDANDNAPEISFSTV--------KEAVSEGAAPGTVVALFSVTDRDSEENGQVQCEL 397

Query: 435 AGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKV 494
            GDVPF+L+      S  K  Y + T  PLD E    YT+ +VA D G P LS++ S++V
Sbjct: 398 LGDVPFRLK------SSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQV 451

Query: 495 QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYS-LEPEPAAKG 553
           QV DVNDNAP F+Q V +V   ENN PG  I  ++A+D D G+NA+L YS LE +     
Sbjct: 452 QVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMS 511

Query: 554 LFT---ISPETGEIQVKTSLDREQRESYELKVVAADRGSP-SLQGTATVLVNVLDCNDND 609
           +FT   I+ E G +    S D EQ + +  +V A D GSP +L G ATV + ++D NDN 
Sbjct: 512 VFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNA 571

Query: 610 PKFM--LSGYNFS-VMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQDN--GDFVI 660
           P  +  L G N +   E +P  +  G     V  +D D GENA++  S+ + N    F +
Sbjct: 572 PAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRM 631

Query: 661 QNGTGTILSS--LSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
              TG + ++  +   R+ Q  Y   ++  D G PP S+   + + ++D
Sbjct: 632 DWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  211 bits (536), Expect = 4e-54
 Identities = 192/676 (28%), Positives = 296/676 (43%), Gaps = 96/676 (14%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           + + VLD NDN P F  P    E+SE++  G       A D D G N+  +Y        
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-----T 162

Query: 326 VRRLLRLDRNT-------GLITVQGPVDREDLSTLRFSVLAKDRG--------------- 363
                 LD  T         + ++ P+DRE  +  R+ + A D G               
Sbjct: 163 PNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222

Query: 364 ----TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQV 419
                  ++  A + + V D NDN P  +              ++ E+    T V  +  
Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFD--------QPVYTVSLPENSPPGTLVIQLNA 274

Query: 420 SDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 479
           +D DEG+N  V    +  +     +A E    S +   L+ +  LDYE+   Y + + A 
Sbjct: 275 TDPDEGQNGEVVYSFSSHIS---PRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAK 331

Query: 480 DSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNA 539
           D G   + +   + V+V+D NDNAP  + S  + A  E   PG V+A  + +D DS  N 
Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391

Query: 540 ELVYSL------EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
           ++   L        + + K  +TI  E         LDRE  +SY L VVA DRG P+L 
Sbjct: 392 QVQCELLGDVPFRLKSSFKNYYTIVTEA-------PLDREAGDSYTLTVVARDRGEPALS 444

Query: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVE- 652
            + ++ V V D NDN P+F    Y+  V EN    + +  V+  D D+G NAQ+  S+  
Sbjct: 445 TSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILE 504

Query: 653 -QDNGDFV-----IQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVL 706
            Q  G  V     I +  G + +  SFD EQ   ++FQ++A D G P   A    T+N+L
Sbjct: 505 CQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAG-NATVNIL 563

Query: 707 --DENDNAPYITAP-----SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
             D+NDNAP I AP        + ++L      G  +++VAA D D G NA L YSI  G
Sbjct: 564 IVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRG 623

Query: 760 NPYGLFQIGSHSGAITLEKEI--ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLA 817
           N   LF++   +G +   + +  +R     + LV++V D G+PP   TA           
Sbjct: 624 NEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTA----------- 672

Query: 818 NRTLLETLLGHSLDTP--LDIDIAGDPEYERSKQRG--------NILFGVVAGVVAVALL 867
             TL+  L+  +++          G  E++R  + G         ++  +  G V+   L
Sbjct: 673 --TLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFL 730

Query: 868 IALAVLVRYCRQREAK 883
           +A+ VL   C Q+E K
Sbjct: 731 LAMIVLAVRC-QKEKK 745



 Score =  184 bits (466), Expect = 5e-46
 Identities = 157/525 (29%), Positives = 226/525 (43%), Gaps = 44/525 (8%)

Query: 319 FHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS-VLAKDRGTNPKSARAQVVVTV 377
           F   P      L L+  TG++ V   +DRE +     S VL  +          QV + V
Sbjct: 53  FQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEV 112

Query: 378 KDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGD 437
            D+NDN P+            D    ISE     T   L    D D G N+     +  +
Sbjct: 113 LDINDNPPSFP--------EPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN 164

Query: 438 VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGN-------------- 483
             F L    +T  D  +   L    PLD E+   +   + AVD G               
Sbjct: 165 SYFSLDV--QTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222

Query: 484 --PPL---SSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538
             PP    + T  L ++V+D NDN P F Q V  V+ PEN+ PG ++ ++ A+D D G N
Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQN 282

Query: 539 AELVYSLEPE--PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
            E+VYS      P A+ LF +SP TG ++V   LD E+   Y++ V A D G  ++    
Sbjct: 283 GEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHC 342

Query: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG 656
            VLV VLD NDN P+   S    +V E     + V + +V D D  EN QVQ  +  D  
Sbjct: 343 KVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV- 401

Query: 657 DFVIQNGTG---TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713
            F +++      TI++    DRE   +YT  + A D G P  S    + + V D NDNAP
Sbjct: 402 PFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAP 461

Query: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS-----IAGGNPYGLFQIG 768
             + P    +  +T     G  +  V+A D D G NA+L YS     I G + +    I 
Sbjct: 462 RFSQPVYDVY--VTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSIN 519

Query: 769 SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRY-GTALVHLYV 812
           S +G +   +  +          V+  D G P    G A V++ +
Sbjct: 520 SENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILI 564


>gi|11036656 protocadherin beta 7 precursor [Homo sapiens]
          Length = 793

 Score =  340 bits (871), Expect = 5e-93
 Identities = 238/703 (33%), Positives = 355/703 (50%), Gaps = 53/703 (7%)

Query: 35  QRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKL-- 92
           +R +    +L L + L  S   A  + Y V EE    T + +LA D G   VG L     
Sbjct: 6   ERAVQKRQVLFLCVFLGMSWAGAEPLRYFVAEETERGTFLTNLAKDLGL-GVGELRARGT 64

Query: 93  ----EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGS 148
               +     L +   TGD+   E  +DRE L  C    P +PC+L F++ +    Q   
Sbjct: 65  RIVSDQNMQILLLSSLTGDLLLNE-KLDREEL--CG---PREPCVLPFQLLLEKPFQ--- 115

Query: 149 PRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ 208
             +   ++ V+DIND+ P F    I+L I E+T  G+ F +  A D D G N +++Y + 
Sbjct: 116 --IFRAELWVRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTIS 173

Query: 209 AGPEAQELFGLQVAEDQEEK-QPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLR 267
             P A   F + V +  E    P+L++   LDRE    + LT+   DGGSPPR+ +AL+R
Sbjct: 174 --PNAY--FHINVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVR 229

Query: 268 VTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVR 327
           + VLD NDNAP F R  Y+ ++ ENSP+G  V+ V A D D G+N EI Y F  A E + 
Sbjct: 230 ILVLDVNDNAPDFVRSLYKVQVPENSPVGSMVVSVSARDLDTGSNGEIAYAFSYATERIL 289

Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387
           +  +++  +G + ++  +D E + T   ++ AKD G    S +  VVV V D+NDN P +
Sbjct: 290 KTFQINPTSGSLHLKAQLDYEAIQTYTLTIQAKDGG--GLSGKCTVVVDVTDINDNRPEL 347

Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447
            +  +         + I+E+ + ET VA+ ++ DRD G N    C +  DVPF L+ + E
Sbjct: 348 LLSSL--------TSPIAEN-SPETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVE 398

Query: 448 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507
                   Y L T  PLD E+  +Y I I   D G P L + +++ V V DVNDNAP FT
Sbjct: 399 ------NFYTLVTEKPLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFT 452

Query: 508 QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL----EPEPAAKGLFTISPETGE 563
           Q+   +   ENN P   I  ++A+D DSG+NA+++YSL    +P      L +I+ + G 
Sbjct: 453 QTSYTLFVRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGH 512

Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV-- 621
           +    SLD E  +++E +V A DRGSP+L   A V V VLD NDN P  +    N S   
Sbjct: 513 LFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPC 572

Query: 622 MENMPALSPVG----MVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSFDR 675
            E +P  +  G     V  +DGD G+NA    QL    + G F +    G + ++     
Sbjct: 573 TEPLPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSE 632

Query: 676 EQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718
              +     +   D G PPRSA   + + ++D   + PY+  P
Sbjct: 633 RDAAKQRLVVLVKDNGEPPRSATATLHVLLVD-GFSQPYLRLP 674



 Score =  224 bits (570), Expect = 4e-58
 Identities = 174/566 (30%), Positives = 255/566 (45%), Gaps = 53/566 (9%)

Query: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
           V D ND+AP F       ++ E++  G + +   A DSD G N+   YT   +P     +
Sbjct: 123 VRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTI--SPNAYFHI 180

Query: 330 LRLDRNTGLI----TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
              D   G I     +   +DRE++     ++ A D G+ P+S  A V + V D+NDNAP
Sbjct: 181 NVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILVLDVNDNAP 240

Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
              +R +  V        + E+    + V  V   D D G N        G++ +    A
Sbjct: 241 DF-VRSLYKV-------QVPENSPVGSMVVSVSARDLDTGSN--------GEIAYAFSYA 284

Query: 446 SE----TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
           +E    T   +     L     LDYE ++ YT+ I A D G   LS   ++ V V D+ND
Sbjct: 285 TERILKTFQINPTSGSLHLKAQLDYEAIQTYTLTIQAKDGGG--LSGKCTVVVDVTDIND 342

Query: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE------PAAKGLF 555
           N P    S       EN+ P  V+A     D DSG+N + V S++ +      P+ +  +
Sbjct: 343 NRPELLLSSLTSPIAENS-PETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVENFY 401

Query: 556 TISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS 615
           T+  E         LDRE+   Y + +   D G+P L+    + V V D NDN P F  +
Sbjct: 402 TLVTEK-------PLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQT 454

Query: 616 GYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQNGTGTIL 668
            Y   V EN     P+G V+  D D G NAQV  S+       +       I    G + 
Sbjct: 455 SYTLFVRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGHLF 514

Query: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP-SNTSHKLLT 727
           +  S D E    + F++ A D G P  S+   V + VLD NDN+P++  P  N+S     
Sbjct: 515 ALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPCTE 574

Query: 728 PQTRLGET---VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRH 784
           P  R  E    V++V A D DSG NA L Y +      GLF + +H+G +   + +  R 
Sbjct: 575 PLPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERD 634

Query: 785 HGLHRLVVKVSDRGKPPRYGTALVHL 810
               RLVV V D G+PPR  TA +H+
Sbjct: 635 AAKQRLVVLVKDNGEPPRSATATLHV 660



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 12/115 (10%)

Query: 705 VLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGL 764
           V D ND+AP +      S K+L   T  G      +A+D D G N+   Y+I+   P   
Sbjct: 123 VRDINDHAP-VFLDREISLKILESTTP-GAAFLLESAQDSDVGTNSLSNYTIS---PNAY 177

Query: 765 FQIGSHSGA-------ITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
           F I  H          + L + ++R       L +   D G PPR GTALV + V
Sbjct: 178 FHINVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILV 232


>gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  338 bits (868), Expect = 1e-92
 Identities = 232/685 (33%), Positives = 352/685 (51%), Gaps = 56/685 (8%)

Query: 31  GPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL- 89
           G  G+   LP + L LL L  P+     R  Y++PEE P  +++G+LA D GF  V  L 
Sbjct: 6   GELGRAERLPVLFLFLLSLFCPALCEQIR--YRIPEEMPKGSVVGNLATDLGF-SVQELP 62

Query: 90  -YKLEVGA--PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
             KL V +  PY  V  ++G++  + + +DRE   E   + P   C LEFE      V  
Sbjct: 63  TRKLRVSSEKPYFTVSAESGELLVS-SRLDRE---EICGKKPA--CALEFEA-----VAE 111

Query: 147 GSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206
                    +E++DIND+TP F      L I E+   G+ F + +A D D G N +  Y+
Sbjct: 112 NPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYK 171

Query: 207 LQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL 265
           L   P     F L + E Q+  K P+L +   LDRE+   + L +   DGG PP + +  
Sbjct: 172 LSLNPS----FSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTE 227

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           LR+ V D NDN P F R  Y   L EN P G +V+QV A D D+G N+EI Y+F++  ++
Sbjct: 228 LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI 287

Query: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
                 L+  +G IT Q  +D E+  T  +S++ + R      A+  V + ++D NDN+P
Sbjct: 288 ----FSLNSKSGEITTQKKLDFEE--TKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSP 341

Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
            +    +        +  I E+    T +AL+++ D+D GEN  V C + G+VPF++   
Sbjct: 342 EVTFHSL--------LEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKII-- 391

Query: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505
               S SK  Y L T   LD E+  +Y + I A D G PPLSS+ S+ + + DVNDNAPV
Sbjct: 392 ----SSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPV 447

Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL---EPEPAAKGLF-TISPET 561
           F Q+   V+ PENN PG  IA++ ASD D G N ++ YS+   + EP A   + ++S ++
Sbjct: 448 FHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507

Query: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYN 618
           G +  + + D EQ  ++EL + A D+GSP+L    ++ V V D NDN P+ +   L    
Sbjct: 508 GVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDG 567

Query: 619 FSVMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLS 672
            ++ + +P  +  G     V  +D D G NA +   V Q  + G F +   TG + ++ +
Sbjct: 568 SALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARA 627

Query: 673 FDREQQSTYTFQLKAVDGGVPPRSA 697
                 +     +   DGG PP SA
Sbjct: 628 LGDRDAARQRLLVAVRDGGQPPLSA 652



 Score =  239 bits (611), Expect = 8e-63
 Identities = 186/626 (29%), Positives = 300/626 (47%), Gaps = 56/626 (8%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           + V + D ND+ PKF + S+E ++SE++  G   I   A D+D G N+  +Y     P  
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSF 178

Query: 326 VRRLLRLDRNTGL----ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMN 381
              L+  ++  G     + ++  +DRE  S  R  + A D G  P S   ++ + V D N
Sbjct: 179 --SLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDAN 236

Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441
           DN P    R +  V+       + E+V   T V  V  +D+DEG N+ +T        + 
Sbjct: 237 DNPPVFN-RDVYRVS-------LRENVPPGTTVLQVSATDQDEGINSEIT--------YS 280

Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
             +  +  S + K   + T   LD+E+ K+Y++ +   D G   L +  ++++ + D ND
Sbjct: 281 FYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDEND 338

Query: 502 NAPVFT-QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560
           N+P  T  S+ E+   EN  PG +IA I   D DSG N E+   L+ E   K + + S  
Sbjct: 339 NSPEVTFHSLLEMIL-ENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFK-IISSSKN 396

Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
           + ++    +LDREQ   Y + + A DRG P L  + +V++++ D NDN P F  + Y  S
Sbjct: 397 SYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVS 456

Query: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN------GDFVIQNG-TGTILSSLSF 673
           V EN P  + +  V   D D G N QV  S+   +        +V  +  +G + +  +F
Sbjct: 457 VPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAF 516

Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTP 728
           D EQ  T+   L+A D G P  SA V + + V D NDNAP +  P+     +    ++  
Sbjct: 517 DYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576

Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788
               G  V++V A D DSG NA L Y +   +  GLF +G  +G +   + +  R     
Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQ 636

Query: 789 RLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSK 848
           RL+V V D G+PP   TA +HL   ++      L+ +L    D P    +  DP+ E   
Sbjct: 637 RLLVAVRDGGQPPLSATATLHLVFADS------LQEVLPDITDRP----VPSDPQAE--- 683

Query: 849 QRGNILFGVVAGVVAVALLIALAVLV 874
               + F +V  +  +++L  LAV++
Sbjct: 684 ----LQFYLVVALALISVLFLLAVIL 705



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 45/239 (18%)

Query: 56  HATRVVYKVPEEQPPNTLIGSLAA---DYGFPD-------VGHLYKLEVGAPYLRVDGKT 105
           H    +  VPE  PP   I  + A   D G             L  L + A Y+ +  ++
Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL-ASYVSMSAQS 507

Query: 106 GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIN 162
           G +F  + + D E LR              FE+++    Q GSP L      ++ V D N
Sbjct: 508 GVVFA-QRAFDYEQLRT-------------FELTLQARDQ-GSPALSANVSLRVLVGDRN 552

Query: 163 DNTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQ 214
           DN P    P +          +P     G L    +A D D+G N   SY  LQA     
Sbjct: 553 DNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL 612

Query: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
              GL+  E +  +      +G+ D  R     L + V+DGG PP +++A L +   D+
Sbjct: 613 FSLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLVFADS 663


>gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 923

 Score =  338 bits (868), Expect = 1e-92
 Identities = 232/685 (33%), Positives = 352/685 (51%), Gaps = 56/685 (8%)

Query: 31  GPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL- 89
           G  G+   LP + L LL L  P+     R  Y++PEE P  +++G+LA D GF  V  L 
Sbjct: 6   GELGRAERLPVLFLFLLSLFCPALCEQIR--YRIPEEMPKGSVVGNLATDLGF-SVQELP 62

Query: 90  -YKLEVGA--PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
             KL V +  PY  V  ++G++  + + +DRE   E   + P   C LEFE      V  
Sbjct: 63  TRKLRVSSEKPYFTVSAESGELLVS-SRLDRE---EICGKKPA--CALEFEA-----VAE 111

Query: 147 GSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206
                    +E++DIND+TP F      L I E+   G+ F + +A D D G N +  Y+
Sbjct: 112 NPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYK 171

Query: 207 LQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL 265
           L   P     F L + E Q+  K P+L +   LDRE+   + L +   DGG PP + +  
Sbjct: 172 LSLNPS----FSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTE 227

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           LR+ V D NDN P F R  Y   L EN P G +V+QV A D D+G N+EI Y+F++  ++
Sbjct: 228 LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI 287

Query: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
                 L+  +G IT Q  +D E+  T  +S++ + R      A+  V + ++D NDN+P
Sbjct: 288 ----FSLNSKSGEITTQKKLDFEE--TKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSP 341

Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
            +    +        +  I E+    T +AL+++ D+D GEN  V C + G+VPF++   
Sbjct: 342 EVTFHSL--------LEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKII-- 391

Query: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505
               S SK  Y L T   LD E+  +Y + I A D G PPLSS+ S+ + + DVNDNAPV
Sbjct: 392 ----SSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPV 447

Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL---EPEPAAKGLF-TISPET 561
           F Q+   V+ PENN PG  IA++ ASD D G N ++ YS+   + EP A   + ++S ++
Sbjct: 448 FHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507

Query: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYN 618
           G +  + + D EQ  ++EL + A D+GSP+L    ++ V V D NDN P+ +   L    
Sbjct: 508 GVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDG 567

Query: 619 FSVMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLS 672
            ++ + +P  +  G     V  +D D G NA +   V Q  + G F +   TG + ++ +
Sbjct: 568 SALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARA 627

Query: 673 FDREQQSTYTFQLKAVDGGVPPRSA 697
                 +     +   DGG PP SA
Sbjct: 628 LGDRDAARQRLLVAVRDGGQPPLSA 652



 Score =  239 bits (611), Expect = 8e-63
 Identities = 186/626 (29%), Positives = 300/626 (47%), Gaps = 56/626 (8%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           + V + D ND+ PKF + S+E ++SE++  G   I   A D+D G N+  +Y     P  
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSF 178

Query: 326 VRRLLRLDRNTGL----ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMN 381
              L+  ++  G     + ++  +DRE  S  R  + A D G  P S   ++ + V D N
Sbjct: 179 --SLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDAN 236

Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441
           DN P    R +  V+       + E+V   T V  V  +D+DEG N+ +T        + 
Sbjct: 237 DNPPVFN-RDVYRVS-------LRENVPPGTTVLQVSATDQDEGINSEIT--------YS 280

Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
             +  +  S + K   + T   LD+E+ K+Y++ +   D G   L +  ++++ + D ND
Sbjct: 281 FYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDEND 338

Query: 502 NAPVFT-QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560
           N+P  T  S+ E+   EN  PG +IA I   D DSG N E+   L+ E   K + + S  
Sbjct: 339 NSPEVTFHSLLEMIL-ENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFK-IISSSKN 396

Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
           + ++    +LDREQ   Y + + A DRG P L  + +V++++ D NDN P F  + Y  S
Sbjct: 397 SYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVS 456

Query: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN------GDFVIQNG-TGTILSSLSF 673
           V EN P  + +  V   D D G N QV  S+   +        +V  +  +G + +  +F
Sbjct: 457 VPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAF 516

Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTP 728
           D EQ  T+   L+A D G P  SA V + + V D NDNAP +  P+     +    ++  
Sbjct: 517 DYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576

Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788
               G  V++V A D DSG NA L Y +   +  GLF +G  +G +   + +  R     
Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQ 636

Query: 789 RLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSK 848
           RL+V V D G+PP   TA +HL   ++      L+ +L    D P    +  DP+ E   
Sbjct: 637 RLLVAVRDGGQPPLSATATLHLVFADS------LQEVLPDITDRP----VPSDPQAE--- 683

Query: 849 QRGNILFGVVAGVVAVALLIALAVLV 874
               + F +V  +  +++L  LAV++
Sbjct: 684 ----LQFYLVVALALISVLFLLAVIL 705



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 45/239 (18%)

Query: 56  HATRVVYKVPEEQPPNTLIGSLAA---DYGFPD-------VGHLYKLEVGAPYLRVDGKT 105
           H    +  VPE  PP   I  + A   D G             L  L + A Y+ +  ++
Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL-ASYVSMSAQS 507

Query: 106 GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIN 162
           G +F  + + D E LR              FE+++    Q GSP L      ++ V D N
Sbjct: 508 GVVFA-QRAFDYEQLRT-------------FELTLQARDQ-GSPALSANVSLRVLVGDRN 552

Query: 163 DNTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQ 214
           DN P    P +          +P     G L    +A D D+G N   SY  LQA     
Sbjct: 553 DNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL 612

Query: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
              GL+  E +  +      +G+ D  R     L + V+DGG PP +++A L +   D+
Sbjct: 613 FSLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLVFADS 663


>gi|9256604 protocadherin beta 11 precursor [Homo sapiens]
          Length = 797

 Score =  338 bits (867), Expect = 2e-92
 Identities = 237/703 (33%), Positives = 360/703 (51%), Gaps = 51/703 (7%)

Query: 34  GQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFP-----DVGH 88
           G R      +L L +LL  S   +    + V EE    + +G+LA D G         G 
Sbjct: 5   GTRTQQIRQVLLLFVLLGMSQAGSETWSFSVAEEMQSGSFVGNLAKDLGLKVRELSSRGA 64

Query: 89  LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGS 148
                     L++D  TGD+  +ET +DRE L  C +    +PC+L  +V    L+QN +
Sbjct: 65  RVVSNDKKQRLQLDINTGDLLLSET-LDREEL--CGSI---EPCVLHLQV----LMQNPT 114

Query: 149 PRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ 208
            + L+ +++V+DIND++P F+   + L IPEN+ +G++F +  A D D G N V SY + 
Sbjct: 115 -QFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTIS 173

Query: 209 AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
             P +     ++V  D   K P+L++   LD E        +   DGGSPPR+ +AL+RV
Sbjct: 174 --PNSHFHIKMRVIPDNR-KYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRV 230

Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRR 328
            V+D NDN+P+FE+  YE ++ ENS +G  ++ V A D D G N EI YTF  A E +R+
Sbjct: 231 VVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRK 290

Query: 329 LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388
              +++ +G IT++ P+D E + +    + A D G      ++ V++ V D+NDNAP I 
Sbjct: 291 TFEINQKSGEITLRAPLDFETIESYSIIIQATDGG--GLFGKSTVIIHVIDVNDNAPEIT 348

Query: 389 IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448
           +  I         + I E+   ET V +  + D D G+N  + C +  D+PF L+ + E 
Sbjct: 349 VSSI--------TSPIPEN-TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVE- 398

Query: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
                  Y L+T  PLD E   +Y I I   D G P L + ++  V V DVNDNAP FTQ
Sbjct: 399 -----NYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQ 453

Query: 509 SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE-----PAAKGLFTISPETGE 563
           +   +   ENN P   I  ++A+D DSG+NA++ YSL P      P A  L +I+ + G 
Sbjct: 454 TSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLA-SLVSINTDNGH 512

Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV-- 621
           +    SLD E  ++++ +V A DRGSP+L   A V V VLD NDN P  +    N S   
Sbjct: 513 LFALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPC 572

Query: 622 MENMPALSPVG----MVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSFDR 675
            E +P  +  G     V  +DGD G+NA    QL    + G F +    G + ++     
Sbjct: 573 TELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSE 632

Query: 676 EQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718
              + +   +   D G PPRSA   + + ++D   + PY+  P
Sbjct: 633 RDAAKHRLVVLVKDNGEPPRSATATLQVLLVD-GFSQPYLPLP 674



 Score =  236 bits (601), Expect = 1e-61
 Identities = 190/633 (30%), Positives = 275/633 (43%), Gaps = 44/633 (6%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE- 324
           + + V D ND++P F       E+ ENSP+G   +   A D D G NA   YT       
Sbjct: 119 IELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTISPNSHF 178

Query: 325 -VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
            +  R++  +R    + +   +D E+L  L F + A D G+ P+S  A V V V D+NDN
Sbjct: 179 HIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVDINDN 238

Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
           +P  E     +         I E+    + + +V   D D G N  + C         +R
Sbjct: 239 SPEFEQAFYEV--------KIRENSILGSLILIVSAWDLDSGTNGEI-CYTFSHASEDIR 289

Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
           +  E    S +   +    PLD+E ++ Y+I I A D G   L   +++ + V+DVNDNA
Sbjct: 290 KTFEINQKSGE---ITLRAPLDFETIESYSIIIQATDGGG--LFGKSTVIIHVIDVNDNA 344

Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
           P  T S      PEN  P  V+   +  D DSG N  +V S+ PE     L +       
Sbjct: 345 PEITVSSITSPIPENT-PETVVMVFSIQDIDSGDNGRIVCSI-PEDLPFVLKSSVENYYT 402

Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
           ++ +  LDRE    Y + +   D G P L+      V V D NDN P F  + Y   V E
Sbjct: 403 LETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTLFVRE 462

Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQNGTGTILSSLSFDRE 676
           N      +G V+  D D G NAQV  S+       +       I    G + +  S D E
Sbjct: 463 NNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHLFALRSLDYE 522

Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP----SNTSHKLLTPQTRL 732
               + F++ A D G P  S+   V + VLD NDN+P++  P    S    +L+      
Sbjct: 523 ALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEP 582

Query: 733 GETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVV 792
           G  V++V A D DSG NA L Y +      GLF + +H+G +   + +  R    HRLVV
Sbjct: 583 GYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVV 642

Query: 793 KVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGN 852
            V D G+PPR  TA               L+ LL      P        P   ++     
Sbjct: 643 LVKDNGEPPRSATA--------------TLQVLLVDGFSQPYLPLPEAAPAQAQADSLTV 688

Query: 853 ILFGVVAGVVAVALL-IALAVLVRYCRQREAKS 884
            L   +A V ++ L  + L V VR CR+  A S
Sbjct: 689 YLVVALASVSSLFLFSVLLFVAVRLCRRSRAAS 721


>gi|11128035 protocadherin gamma subfamily B, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  334 bits (856), Expect = 3e-91
 Identities = 235/675 (34%), Positives = 339/675 (50%), Gaps = 53/675 (7%)

Query: 42  MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL--YKLEVGAP-- 97
           +LL  LL L P      ++ Y +PEE   N+++G+LA D G   V  L   KL V A   
Sbjct: 16  VLLPFLLSLFPG-ALPVQIRYSIPEELAKNSVVGNLAKDLGL-SVRDLPARKLRVSAEKE 73

Query: 98  YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIE 157
           Y  V+ ++GD+  ++  IDRE +  C  Q     C+L+F     D V      +    + 
Sbjct: 74  YFTVNPESGDLLVSDR-IDREQI--CGKQ---PLCVLDF-----DTVAENPLNIFYIAVI 122

Query: 158 VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF 217
           VQDINDNTP F    I L I E+T  G+ FP+  A D D GPN +  Y L       E F
Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDN----EYF 178

Query: 218 GLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDN 276
            L   +  +  K P+LI+  +LDRE    + L +   DGG PP++ +  +R+ V D NDN
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238

Query: 277 APKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNT 336
            P F +  Y   L E+ P G  V+QV A D D+G NAEI Y+FH   E V+    L+  T
Sbjct: 239 PPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKT 298

Query: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396
           G IT +  +D E  S+   S+ AKD G    +A   + V + D ND AP + +  +    
Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVS--- 353

Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
                  + ED    T +AL++  DRD GEN  V C V G+  F L+      S SK  Y
Sbjct: 354 -----TPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILK------SSSKNYY 402

Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516
            L T   LD E++ +Y + I A D G PPLSS+  + + + DVNDNAPVF Q+   V   
Sbjct: 403 KLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVA 462

Query: 517 ENNKPGEVIAEITASDADSGSNAELVYS-----LEPEPAAKGLFTISPETGEIQVKTSLD 571
           ENN PG  IA+I+ASD D G + ++ YS     L+P        ++S ++G +  + + D
Sbjct: 463 ENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREIL-SYVSVSAQSGVVFAQRAFD 521

Query: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYNFSVMENMPAL 628
            EQ  ++EL + A D+GSP+L    ++ V V D NDN P+ +   L     ++ + +P  
Sbjct: 522 HEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRA 581

Query: 629 SPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLSFDREQQSTYT 682
           +  G     V  +D D G NA +   V Q  + G F +   TG + ++ +      +   
Sbjct: 582 AEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQR 641

Query: 683 FQLKAVDGGVPPRSA 697
             +   DGG PP SA
Sbjct: 642 LLVAVRDGGQPPLSA 656



 Score =  221 bits (563), Expect = 3e-57
 Identities = 189/665 (28%), Positives = 298/665 (44%), Gaps = 54/665 (8%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP-- 323
           + V V D NDN P F++     ++ E++  G +     A DSD G N+   Y  +     
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178

Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
           ++  +     R    + ++  +DRE+ S  +  + A D G  P+S   Q+ + V D NDN
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238

Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
            P    + +  VT       + EDV     V  V  +DRDEG NA +T     +V  Q++
Sbjct: 239 PPVFS-QDVYRVT-------LREDVPPGFFVLQVTATDRDEGINAEITYSFH-NVDEQVK 289

Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                   ++K   + T   LD+E    YT+ I A D G+  L++  S++V+++D ND A
Sbjct: 290 HFFNL---NEKTGEITTKDDLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344

Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
           P    +      PE++ PG VIA I   D DSG N E VY      A   L + S    +
Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGE-VYCQVLGNAKFILKSSSKNYYK 403

Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
           +    +LDRE+   Y L + A D G P L  +  V +++ D NDN P F  + Y   V E
Sbjct: 404 LVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAE 463

Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-------GDFVIQNGTGTILSSLSFDRE 676
           N P  + +  ++  D D G + QV  S+   +           +   +G + +  +FD E
Sbjct: 464 NNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE 523

Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTPQTR 731
           Q   +   L+A D G P  SA V + + V D NDNAP +  P+     +    ++     
Sbjct: 524 QLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAE 583

Query: 732 LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791
            G  V++V A D DSG NA L Y +   +  GLF +G  +G +   + +  R     RL+
Sbjct: 584 PGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLL 643

Query: 792 VKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRG 851
           V V D G+PP   TA +HL   ++L  + +L  L                   E S  + 
Sbjct: 644 VAVRDGGQPPLSATATLHLIFADSL--QEVLPDL---------------SDRREPSDPQA 686

Query: 852 NILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKG--- 908
            + F +V  +  +++L  LAV++    +    S     + +  D + P  S K   G   
Sbjct: 687 KLQFYLVVALALISVLFFLAVILAISLRLRLSS-----RSDAWDCFQPGLSSKPGPGVLP 741

Query: 909 NKSKG 913
           N S+G
Sbjct: 742 NYSEG 746



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 61/238 (25%), Positives = 95/238 (39%), Gaps = 47/238 (19%)

Query: 58  TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGA-----------PYLRVDGKTG 106
           T  +  V E  PP   I  ++A    PD+G   ++                Y+ V  ++G
Sbjct: 455 TSYMVHVAENNPPGASIAQISASD--PDLGPSGQVSYSIVASDLKPREILSYVSVSAQSG 512

Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIND 163
            +F  + + D E LR              FE+++    Q GSP L      ++ V D+ND
Sbjct: 513 VVFA-QRAFDHEQLRA-------------FELTLQARDQ-GSPALSANVSLRVLVGDLND 557

Query: 164 NTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQE 215
           N P    P +          +P     G L    +A D D+G N   SY  LQA      
Sbjct: 558 NAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLF 617

Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
             GL+  E +  +      +G+ D  R     L + V+DGG PP +++A L +   D+
Sbjct: 618 SLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLIFADS 667


>gi|14270493 protocadherin gamma subfamily B, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 811

 Score =  334 bits (856), Expect = 3e-91
 Identities = 235/675 (34%), Positives = 339/675 (50%), Gaps = 53/675 (7%)

Query: 42  MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL--YKLEVGAP-- 97
           +LL  LL L P      ++ Y +PEE   N+++G+LA D G   V  L   KL V A   
Sbjct: 16  VLLPFLLSLFPG-ALPVQIRYSIPEELAKNSVVGNLAKDLGL-SVRDLPARKLRVSAEKE 73

Query: 98  YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIE 157
           Y  V+ ++GD+  ++  IDRE +  C  Q     C+L+F     D V      +    + 
Sbjct: 74  YFTVNPESGDLLVSDR-IDREQI--CGKQ---PLCVLDF-----DTVAENPLNIFYIAVI 122

Query: 158 VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF 217
           VQDINDNTP F    I L I E+T  G+ FP+  A D D GPN +  Y L       E F
Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDN----EYF 178

Query: 218 GLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDN 276
            L   +  +  K P+LI+  +LDRE    + L +   DGG PP++ +  +R+ V D NDN
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238

Query: 277 APKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNT 336
            P F +  Y   L E+ P G  V+QV A D D+G NAEI Y+FH   E V+    L+  T
Sbjct: 239 PPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKT 298

Query: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396
           G IT +  +D E  S+   S+ AKD G    +A   + V + D ND AP + +  +    
Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVS--- 353

Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
                  + ED    T +AL++  DRD GEN  V C V G+  F L+      S SK  Y
Sbjct: 354 -----TPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILK------SSSKNYY 402

Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516
            L T   LD E++ +Y + I A D G PPLSS+  + + + DVNDNAPVF Q+   V   
Sbjct: 403 KLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVA 462

Query: 517 ENNKPGEVIAEITASDADSGSNAELVYS-----LEPEPAAKGLFTISPETGEIQVKTSLD 571
           ENN PG  IA+I+ASD D G + ++ YS     L+P        ++S ++G +  + + D
Sbjct: 463 ENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREIL-SYVSVSAQSGVVFAQRAFD 521

Query: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYNFSVMENMPAL 628
            EQ  ++EL + A D+GSP+L    ++ V V D NDN P+ +   L     ++ + +P  
Sbjct: 522 HEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRA 581

Query: 629 SPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLSFDREQQSTYT 682
           +  G     V  +D D G NA +   V Q  + G F +   TG + ++ +      +   
Sbjct: 582 AEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQR 641

Query: 683 FQLKAVDGGVPPRSA 697
             +   DGG PP SA
Sbjct: 642 LLVAVRDGGQPPLSA 656



 Score =  221 bits (563), Expect = 3e-57
 Identities = 189/665 (28%), Positives = 298/665 (44%), Gaps = 54/665 (8%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP-- 323
           + V V D NDN P F++     ++ E++  G +     A DSD G N+   Y  +     
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178

Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
           ++  +     R    + ++  +DRE+ S  +  + A D G  P+S   Q+ + V D NDN
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238

Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
            P    + +  VT       + EDV     V  V  +DRDEG NA +T     +V  Q++
Sbjct: 239 PPVFS-QDVYRVT-------LREDVPPGFFVLQVTATDRDEGINAEITYSFH-NVDEQVK 289

Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
                   ++K   + T   LD+E    YT+ I A D G+  L++  S++V+++D ND A
Sbjct: 290 HFFNL---NEKTGEITTKDDLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344

Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
           P    +      PE++ PG VIA I   D DSG N E VY      A   L + S    +
Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGE-VYCQVLGNAKFILKSSSKNYYK 403

Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
           +    +LDRE+   Y L + A D G P L  +  V +++ D NDN P F  + Y   V E
Sbjct: 404 LVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAE 463

Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-------GDFVIQNGTGTILSSLSFDRE 676
           N P  + +  ++  D D G + QV  S+   +           +   +G + +  +FD E
Sbjct: 464 NNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE 523

Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTPQTR 731
           Q   +   L+A D G P  SA V + + V D NDNAP +  P+     +    ++     
Sbjct: 524 QLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAE 583

Query: 732 LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791
            G  V++V A D DSG NA L Y +   +  GLF +G  +G +   + +  R     RL+
Sbjct: 584 PGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLL 643

Query: 792 VKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRG 851
           V V D G+PP   TA +HL   ++L  + +L  L                   E S  + 
Sbjct: 644 VAVRDGGQPPLSATATLHLIFADSL--QEVLPDL---------------SDRREPSDPQA 686

Query: 852 NILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKG--- 908
            + F +V  +  +++L  LAV++    +    S     + +  D + P  S K   G   
Sbjct: 687 KLQFYLVVALALISVLFFLAVILAISLRLRLSS-----RSDAWDCFQPGLSSKPGPGVLP 741

Query: 909 NKSKG 913
           N S+G
Sbjct: 742 NYSEG 746



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 61/238 (25%), Positives = 95/238 (39%), Gaps = 47/238 (19%)

Query: 58  TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGA-----------PYLRVDGKTG 106
           T  +  V E  PP   I  ++A    PD+G   ++                Y+ V  ++G
Sbjct: 455 TSYMVHVAENNPPGASIAQISASD--PDLGPSGQVSYSIVASDLKPREILSYVSVSAQSG 512

Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIND 163
            +F  + + D E LR              FE+++    Q GSP L      ++ V D+ND
Sbjct: 513 VVFA-QRAFDHEQLRA-------------FELTLQARDQ-GSPALSANVSLRVLVGDLND 557

Query: 164 NTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQE 215
           N P    P +          +P     G L    +A D D+G N   SY  LQA      
Sbjct: 558 NAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLF 617

Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
             GL+  E +  +      +G+ D  R     L + V+DGG PP +++A L +   D+
Sbjct: 618 SLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLIFADS 667


>gi|9256606 protocadherin beta 12 precursor [Homo sapiens]
          Length = 795

 Score =  333 bits (853), Expect = 7e-91
 Identities = 236/704 (33%), Positives = 355/704 (50%), Gaps = 51/704 (7%)

Query: 33  GGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKL 92
           GG   L    +L   +LL  S   +    + V EE    + +G+LA   G  +V  L   
Sbjct: 4   GGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGL-EVSELSSR 62

Query: 93  EV------GAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
                       L++D  TGD+   E  +DRE L  C +    +PC+L F+V + +  Q 
Sbjct: 63  GARVVSNDNKECLQLDTNTGDLLLREM-LDREEL--CGSN---EPCVLYFQVLMKNPTQ- 115

Query: 147 GSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206
                L+ +++V+DIND++P F    + L IPEN+ +G++F +  A D D G N V SY 
Sbjct: 116 ----FLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYT 171

Query: 207 LQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALL 266
           +   P +     ++V  D   K P+L++   LD E        +   DGGSPPR+ +AL+
Sbjct: 172 IN--PNSHFHVKIRVNPDNR-KYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALV 228

Query: 267 RVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326
           RV V+D NDN+P+FE+  YE ++ ENS +G  V+ V A D D G N+E+ YTF  A E +
Sbjct: 229 RVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDI 288

Query: 327 RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386
           R+   +++ +G IT+  P+D E + +    + A D G      ++ V + V D+NDNAP 
Sbjct: 289 RKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGG--GLFGKSTVRIQVMDVNDNAPE 346

Query: 387 IEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQAS 446
           I +  I         + I E+   ET V + ++ DRD G+N  + C +  D+PF L+   
Sbjct: 347 ITVSSI--------TSPIPEN-TPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLK--- 394

Query: 447 ETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVF 506
              S     Y L+T  PLD E   +Y I I   D G P L + +++ V V DVNDNAP F
Sbjct: 395 ---SSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAF 451

Query: 507 TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL----EPEPAAKGLFTISPETG 562
           TQ+   +   ENN P   I  I+A+D DSG+NA++ YSL    +P      L +I+ + G
Sbjct: 452 TQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNG 511

Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV- 621
            +    SLD E  + ++ +V A D GSP+L   A V V VLD NDN P  +    N S  
Sbjct: 512 HLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAP 571

Query: 622 -MENMP-ALSP---VGMVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSFD 674
             E +P A  P   V  V  +DGD G+NA    QL    + G F +    G + ++    
Sbjct: 572 CTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLS 631

Query: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718
               + +   +   D G PPRSA   + + ++D   + PY+  P
Sbjct: 632 ERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD-GFSQPYLPLP 674



 Score =  237 bits (605), Expect = 4e-62
 Identities = 178/562 (31%), Positives = 260/562 (46%), Gaps = 37/562 (6%)

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE- 324
           + + V D ND++P F       E+ ENSP+G   +   A D D G NA   YT +     
Sbjct: 119 IELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHF 178

Query: 325 -VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383
            V  R+   +R    + +   +D E+   L F + A D G+ P+S  A V V V D+NDN
Sbjct: 179 HVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDN 238

Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443
           +P  E     +         I E+    + V  V   D D G N+        ++ +   
Sbjct: 239 SPEFEQAFYEV--------KILENSILGSLVVTVSAWDLDSGTNS--------ELSYTFS 282

Query: 444 QASE----TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDV 499
            ASE    T   ++K   +  T PLD+E ++ Y+I I A D G   L   +++++QV+DV
Sbjct: 283 HASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGG--LFGKSTVRIQVMDV 340

Query: 500 NDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559
           NDNAP  T S      PEN  P  V+      D DSG N ++V S+ PE     L +   
Sbjct: 341 NDNAPEITVSSITSPIPENT-PETVVMVFRIRDRDSGDNGKMVCSI-PEDIPFVLKSSVN 398

Query: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
               ++ +  LDRE R  Y + +   D G+P L+    + V V D NDN P F  + Y  
Sbjct: 399 NYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYAL 458

Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQNGTGTILSSLS 672
            V EN      +G ++  D D G NAQV  S+       +       I    G + +  S
Sbjct: 459 FVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRS 518

Query: 673 FDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP----SNTSHKLLTP 728
            D E    + F++ A D G P  S+   V + VLD NDN+P++  P    S    +L+  
Sbjct: 519 LDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPW 578

Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788
               G  V++V A D DSG NA L Y +      GLF + +H+G +   + +  R    H
Sbjct: 579 AAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKH 638

Query: 789 RLVVKVSDRGKPPRYGTALVHL 810
           RLVV V D G+PPR  TA +H+
Sbjct: 639 RLVVLVKDNGEPPRSATATLHV 660



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 50/211 (23%), Positives = 85/211 (40%), Gaps = 26/211 (12%)

Query: 618 NFSVMENMPALSPVGMVTVIDGDKGENAQVQLS--VEQDNGDFV-IQNGTGTILSSLSFD 674
           NF VME + + S VG +    G +      + +  V  DN + + +   TG +L     D
Sbjct: 32  NFLVMEELQSGSFVGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLD 91

Query: 675 REQ------QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728
           RE+           FQ+   +      + ++ + + V D ND++P            +  
Sbjct: 92  REELCGSNEPCVLYFQVLMKNP-----TQFLQIELQVRDINDHSPVFLEKEMLLE--IPE 144

Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGA-------ITLEKEIE 781
            + +G      +A+D D G+NA   Y+I   NP   F +             + L+K ++
Sbjct: 145 NSPVGAVFLLESAKDLDVGINAVKSYTI---NPNSHFHVKIRVNPDNRKYPELVLDKALD 201

Query: 782 RRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
                    ++   D G PPR GTALV + V
Sbjct: 202 YEERPELSFILTALDGGSPPRSGTALVRVVV 232


>gi|9256610 protocadherin beta 15 precursor [Homo sapiens]
          Length = 787

 Score =  333 bits (853), Expect = 7e-91
 Identities = 237/705 (33%), Positives = 352/705 (49%), Gaps = 51/705 (7%)

Query: 32  PGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYK 91
           P G+R      +L LLLLL  +        Y V EE    + + +LA D G   VG L +
Sbjct: 3   PAGERFPEQRQVLILLLLLEVTLAGWEPRRYSVMEETERGSFVANLANDLGL-GVGELAE 61

Query: 92  L------EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145
                  E     L++D +TG +   E  +DRE L  C    P +PCI+ F+V +   ++
Sbjct: 62  RGARVVSEDNEQGLQLDLQTGQLILNE-KLDREKL--CG---PTEPCIMHFQVLLKKPLE 115

Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205
                +   ++ V DIND++P F    +TL IPE +++G++FP+  A D D G N V +Y
Sbjct: 116 -----VFRAELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNY 170

Query: 206 ELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL 265
            +   P +      +   D   K P+L++   LDRE      LT+   DGGSPPR+ +  
Sbjct: 171 NIS--PNSHFHVSTRTRGDGR-KYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQ 227

Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325
           + + VLD NDNAP+F +  YE ++ ENSP+G  V++V A D D G N EI Y+ + + + 
Sbjct: 228 ILILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQE 287

Query: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
           + +   L   +G I +   +D E +S+    + A D G    S +  V V V D+NDN P
Sbjct: 288 IDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFP 345

Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
            + I  +         + I E+ + ET VAL ++ DRD GEN  + C +  DVPF+L+ +
Sbjct: 346 ELSISSL--------TSPIPEN-SPETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPS 396

Query: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505
            E        Y L T   LD E   +Y I I   D G P L +  S+ V V DVNDNAP 
Sbjct: 397 VE------NFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPA 450

Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL----EPEPAAKGLFTISPET 561
           FTQ+   +   ENN P   I  ++A+D DSG+NA++ YSL    +P      L +I+ + 
Sbjct: 451 FTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDN 510

Query: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV 621
           G +    SLD E  +++E +V A DRG P+L   A V V VLD NDN P  +    N S 
Sbjct: 511 GHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSA 570

Query: 622 --MENMPALSPVG----MVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSF 673
              E +P  +  G     V  +DGD G+NA    QL    + G F +    G + ++   
Sbjct: 571 PCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLL 630

Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718
                + +   +   D G PPRSA   + + ++D   + PY+  P
Sbjct: 631 SERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD-GFSQPYLPLP 674



 Score =  224 bits (571), Expect = 3e-58
 Identities = 215/739 (29%), Positives = 317/739 (42%), Gaps = 81/739 (10%)

Query: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235
           ++ E T  GS F   LA+D   G   +A    +   E  E  GLQ+    + +  QLI+ 
Sbjct: 34  SVMEETERGS-FVANLANDLGLGVGELAERGARVVSEDNEQ-GLQL----DLQTGQLILN 87

Query: 236 GNLDRERWDS--------YDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEA 287
             LDRE+           + + +K      P     A L VT  D ND++P+F       
Sbjct: 88  EKLDREKLCGPTEPCIMHFQVLLK-----KPLEVFRAELLVT--DINDHSPEFPEREMTL 140

Query: 288 ELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE--VVRRLLRLDRNTGLITVQGPV 345
           ++ E S +G      KA D D G+N    Y         V  R     R    + +   +
Sbjct: 141 KIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTEL 200

Query: 346 DREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANIS 405
           DRE+ + LR ++ A D G+ P+S   Q+++ V D NDNAP   ++ +  V        + 
Sbjct: 201 DREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEF-VQALYEV-------QVP 252

Query: 406 EDVAEETAVALVQVSDRDEGENAAVTCVVAG-----DVPFQLRQASETGSDSKKKYFLQT 460
           E+    + V  V   D D G N  ++  +       D PF+L   S      KK      
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKK------ 306

Query: 461 TTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNK 520
              LD+E +  Y ++I A D G   LS   S+ V+V+DVNDN P  + S      PEN+ 
Sbjct: 307 ---LDFETMSSYDLDIEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSP 361

Query: 521 PGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE---IQVKTSLDREQRES 577
             EV A     D DSG N +++ S++ +      F + P       +  + +LDRE R  
Sbjct: 362 ETEV-ALFRIRDRDSGENGKMICSIQDDVP----FKLKPSVENFYRLVTEGALDRETRAE 416

Query: 578 YELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 637
           Y + +   D G+P L+   ++ V V D NDN P F  + Y   V EN      +G V+  
Sbjct: 417 YNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSAT 476

Query: 638 DGDKGENAQVQLSVEQDNGDFV-------IQNGTGTILSSLSFDREQQSTYTFQLKAVDG 690
           D D G NAQV  S+       +       I    G + +  S D E    + F++ A D 
Sbjct: 477 DRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDR 536

Query: 691 GVPPRSAYVGVTINVLDENDNAPYITAP----SNTSHKLLTPQTRLGETVSQVAAEDFDS 746
           G P  S+   V + VLD NDN+P++  P    S    +L+      G  V++V A D DS
Sbjct: 537 GFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDS 596

Query: 747 GVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTA 806
           G NA L Y +      GLF + +H+G +   + +  R    HRLVV V D G+PPR  TA
Sbjct: 597 GQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATA 656

Query: 807 LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866
                          L+ LL      P        P   ++      L   +A V ++ L
Sbjct: 657 --------------TLQVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFL 702

Query: 867 L-IALAVLVRYCRQREAKS 884
             + L V VR CR+  A S
Sbjct: 703 FSVFLFVAVRLCRRSRAAS 721


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.132    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,954,601
Number of Sequences: 37866
Number of extensions: 2322381
Number of successful extensions: 14880
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 5670
Number of HSP's gapped (non-prelim): 1098
length of query: 1060
length of database: 18,247,518
effective HSP length: 113
effective length of query: 947
effective length of database: 13,968,660
effective search space: 13228321020
effective search space used: 13228321020
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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