BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] (1060 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 2107 0.0 gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 2046 0.0 gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens] 968 0.0 gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens] 967 0.0 gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens] 903 0.0 gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 698 0.0 gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 698 0.0 gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 663 0.0 gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 663 0.0 gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 660 0.0 gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 660 0.0 gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 654 0.0 gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 654 0.0 gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 654 0.0 gi|190194360 protocadherin 20 [Homo sapiens] 436 e-122 gi|94538350 protocadherin 17 precursor [Homo sapiens] 353 5e-97 gi|16933557 dachsous 1 precursor [Homo sapiens] 348 1e-95 gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 343 4e-94 gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 342 8e-94 gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 342 8e-94 gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens] 340 4e-93 gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens] 340 4e-93 gi|11036656 protocadherin beta 7 precursor [Homo sapiens] 340 5e-93 gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs... 338 1e-92 gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs... 338 1e-92 gi|9256604 protocadherin beta 11 precursor [Homo sapiens] 338 2e-92 gi|11128035 protocadherin gamma subfamily B, 2 isoform 1 precurs... 334 3e-91 gi|14270493 protocadherin gamma subfamily B, 2 isoform 2 precurs... 334 3e-91 gi|9256606 protocadherin beta 12 precursor [Homo sapiens] 333 7e-91 gi|9256610 protocadherin beta 15 precursor [Homo sapiens] 333 7e-91 >gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] Length = 1060 Score = 2107 bits (5460), Expect = 0.0 Identities = 1060/1060 (100%), Positives = 1060/1060 (100%) Query: 1 MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60 MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV Sbjct: 1 MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60 Query: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120 VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL Sbjct: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120 Query: 121 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN Sbjct: 121 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180 Query: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR Sbjct: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240 Query: 241 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI Sbjct: 241 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300 Query: 301 QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360 QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK Sbjct: 301 QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360 Query: 361 DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420 DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS Sbjct: 361 DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420 Query: 421 DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480 DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD Sbjct: 421 DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480 Query: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540 Query: 541 LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600 LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV Sbjct: 541 LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600 Query: 601 NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660 NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI Sbjct: 601 NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660 Query: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN Sbjct: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720 Query: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI Sbjct: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780 Query: 781 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG Sbjct: 781 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840 Query: 841 DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900 DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK Sbjct: 841 DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900 Query: 901 PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960 PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP Sbjct: 901 PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960 Query: 961 GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020 GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY Sbjct: 961 GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020 Query: 1021 SYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE 1060 SYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE Sbjct: 1021 SYRTNPPKYPSKQVGQPFQLSTPQPLPHPYHGAIWTEVWE 1060 >gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] Length = 1237 Score = 2046 bits (5300), Expect = 0.0 Identities = 1033/1034 (99%), Positives = 1034/1034 (100%) Query: 1 MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60 MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV Sbjct: 1 MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRV 60 Query: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120 VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL Sbjct: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120 Query: 121 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN Sbjct: 121 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180 Query: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR Sbjct: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDR 240 Query: 241 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI Sbjct: 241 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVI 300 Query: 301 QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360 QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK Sbjct: 301 QVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAK 360 Query: 361 DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420 DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS Sbjct: 361 DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420 Query: 421 DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480 DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD Sbjct: 421 DRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD 480 Query: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE 540 Query: 541 LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600 LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV Sbjct: 541 LVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLV 600 Query: 601 NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660 NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI Sbjct: 601 NVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI 660 Query: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN Sbjct: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720 Query: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI Sbjct: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780 Query: 781 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG Sbjct: 781 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAG 840 Query: 841 DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900 DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK Sbjct: 841 DPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPK 900 Query: 901 PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960 PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP Sbjct: 901 PSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPP 960 Query: 961 GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020 GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY Sbjct: 961 GSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020 Query: 1021 SYRTNPPKYPSKQV 1034 SYRTNPPKYPSKQ+ Sbjct: 1021 SYRTNPPKYPSKQL 1034 >gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens] Length = 1072 Score = 968 bits (2503), Expect = 0.0 Identities = 524/1048 (50%), Positives = 706/1048 (67%), Gaps = 66/1048 (6%) Query: 46 LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102 LLL L+ S A +++ Y++ EE P + IG++A+D G G + + LE G+ YL++D Sbjct: 19 LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78 Query: 103 GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162 TG++ T+E IDRE L +CQ + C L+FEVS+ Q+ L EGQ+ V DIN Sbjct: 79 NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137 Query: 163 DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP----------- 211 DNTP F SPV+TL + EN +G+L+ +P A+DRD G NG+ YEL P Sbjct: 138 DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197 Query: 212 -----------------------------EAQE------------LFGLQVAEDQE-EKQ 229 +A E +F LQVA+ + EKQ Sbjct: 198 AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257 Query: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAEL 289 PQLIV G LDRE+ DSY+LT++V+DGG PPR+S A+LRV + D NDN+P+FE+ YEA+L Sbjct: 258 PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317 Query: 290 SENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED 349 +ENS G ++Q++A D D G N +IEY F A E VRRLLRLD +G ++V +DRE+ Sbjct: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377 Query: 350 LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409 ++ LRF+V+A+DRG PK+ +A VV+ +KD NDN P+IEIR IG + +DG+AN++EDV Sbjct: 378 VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437 Query: 410 EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GSDSKKKYFLQTTTPLDYEK 468 +T +ALVQVSDRD+GEN VTC V GDVPFQL+ AS+T G +KKKYFL T+TPLDYE Sbjct: 438 VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497 Query: 469 VKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEI 528 +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV EV FPENN PGE +A + Sbjct: 498 TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557 Query: 529 TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588 A+DADSG NAE+ YSL+ + G+F I P++G+I V T LDREQ + YE KV A D+G Sbjct: 558 LATDADSGKNAEIAYSLDS--SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615 Query: 589 SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648 P LQG+ TV+V V D NDNDPKFM + F V EN+ SPVGMVTV+D DKG NA++ Sbjct: 616 IPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMS 675 Query: 649 LSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708 L +E++N F I+N TGTI S++SFDRE Q+TYTF++KAVDGG PPRSA V++ V+DE Sbjct: 676 LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDE 735 Query: 709 NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIG 768 NDNAP +T P N S+ LL P + + V+ V A D D G+NA+L YSI GGNP+ LF+I Sbjct: 736 NDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEID 795 Query: 769 SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGH 828 SG ++L ++ ++H+GLHRLVV+V+D G+P + T LVH++VNE+++N T +++ + Sbjct: 796 PTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855 Query: 829 SLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQA 888 SL PL DIAGDP YE SKQR +I+ GVVAG++ V L+I + V+ RYCR + K+GY+A Sbjct: 856 SLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKN-KNGYEA 914 Query: 889 GKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGD 948 GKK+ +D + P+ K+ K K K K KS +P+ EA +++ +++ D Sbjct: 915 GKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSD 973 Query: 949 SPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGT 1006 SP + + +N PGSPDL RHY+S+SPLP++QL PQSP+A KKHQ VQDLPPANTFVG Sbjct: 974 SPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033 Query: 1007 GDTTSTGSEQYSDYSYRTNPPKYPSKQV 1034 GD S GS+ S+YS +TN KY SKQV Sbjct: 1034 GDNISIGSDHCSEYSCQTN-NKY-SKQV 1059 >gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens] Length = 1069 Score = 967 bits (2500), Expect = 0.0 Identities = 523/1048 (49%), Positives = 706/1048 (67%), Gaps = 66/1048 (6%) Query: 46 LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102 LLL L+ S A +++ Y++ EE P + IG++A+D G G + + LE G+ YL++D Sbjct: 19 LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78 Query: 103 GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162 TG++ T+E IDRE L +CQ + C L+FEVS+ Q+ L EGQ+ V DIN Sbjct: 79 NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137 Query: 163 DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP----------- 211 DNTP F SPV+TL + EN +G+L+ +P A+DRD G NG+ YEL P Sbjct: 138 DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197 Query: 212 -----------------------------EAQE------------LFGLQVAEDQE-EKQ 229 +A E +F LQVA+ + EKQ Sbjct: 198 AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257 Query: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAEL 289 PQLIV G LDRE+ DSY+LT++V+DGG PPR+S A+LRV + D NDN+P+FE+ YEA+L Sbjct: 258 PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317 Query: 290 SENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED 349 +ENS G ++Q++A D D G N +IEY F A E VRRLLRLD +G ++V +DRE+ Sbjct: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377 Query: 350 LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409 ++ LRF+V+A+DRG PK+ +A VV+ +KD NDN P+IEIR IG + +DG+AN++EDV Sbjct: 378 VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437 Query: 410 EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GSDSKKKYFLQTTTPLDYEK 468 +T +ALVQVSDRD+GEN VTC V GDVPFQL+ AS+T G +KKKYFL T+TPLDYE Sbjct: 438 VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497 Query: 469 VKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEI 528 +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV EV FPENN PGE +A + Sbjct: 498 TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557 Query: 529 TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588 A+DADSG NAE+ YSL+ + G+F I P++G+I V T LDREQ + YE KV A D+G Sbjct: 558 LATDADSGKNAEIAYSLDS--SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615 Query: 589 SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648 P LQG+ TV+V V D NDNDPKFM + F V EN+ SPVGMVTV+D DKG NA++ Sbjct: 616 IPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMS 675 Query: 649 LSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708 L +E++N F I+N TGTI S++SFDRE Q+TYTF++KAVDGG PPRSA V++ V+DE Sbjct: 676 LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDE 735 Query: 709 NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIG 768 NDNAP +T P N S+ LL P + + V+ V A D D G+NA+L YSI GGNP+ LF+I Sbjct: 736 NDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEID 795 Query: 769 SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGH 828 SG ++L ++ ++H+GLHRLVV+V+D G+P + T LVH++VNE+++N T +++ + Sbjct: 796 PTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855 Query: 829 SLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQA 888 SL PL DIAGDP YE SKQR +I+ GVVAG++ V L+I + V+ RYCR + K+GY+A Sbjct: 856 SLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKN-KNGYEA 914 Query: 889 GKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGD 948 GKK+ +D + P+ K+ K K K K KS +P+ EA +++ +++ D Sbjct: 915 GKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSD 973 Query: 949 SPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGT 1006 SP + + +N PGSPDL RHY+S+SPLP++QL PQSP+A KKHQ VQDLPPANTFVG Sbjct: 974 SPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033 Query: 1007 GDTTSTGSEQYSDYSYRTNPPKYPSKQV 1034 GD S GS+ S+YS +TN KY SKQ+ Sbjct: 1034 GDNISIGSDHCSEYSCQTN-NKY-SKQM 1059 >gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens] Length = 1200 Score = 903 bits (2333), Expect = 0.0 Identities = 494/1021 (48%), Positives = 674/1021 (66%), Gaps = 32/1021 (3%) Query: 46 LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102 LLL L+ S A +++ Y++ EE P + IG++A+D G G + + LE G+ YL++D Sbjct: 19 LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78 Query: 103 GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162 TG++ T+E IDRE L +CQ + C L+FEVS+ Q+ L EGQ+ V DIN Sbjct: 79 NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137 Query: 163 DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVA 222 DNTP F SPV+TL + EN +G+L+ +P A+DRD G NG+ YEL P G Sbjct: 138 DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197 Query: 223 EDQEEKQPQLIVMGN--------LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274 + P GN + R D+ + GG+ P S++ + V DT Sbjct: 198 AGAADSAPYPGGGGNGASGGGSGGSKRRLDASE-----GGGGTNPGGRSSVFELQVADTP 252 Query: 275 DNAPK---FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLR 331 D + + YEA+L+ENS G ++Q++A D D G N +IEY F A E VRRLLR Sbjct: 253 DGEKQPQLIVKGVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLR 312 Query: 332 LDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391 LD +G ++V +DRE+++ LRF+V+A+DRG PK+ +A VV+ +KD NDN P+IEIR Sbjct: 313 LDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRK 372 Query: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GS 450 IG + +DG+AN++EDV +T +ALVQVSDRD+GEN VTC V GDVPFQL+ AS+T G Sbjct: 373 IGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGD 432 Query: 451 DSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV 510 +KKKYFL T+TPLDYE +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV Sbjct: 433 QNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSV 492 Query: 511 TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570 EV FPENN PGE +A + A+DADSG NAE+ YSL + + G+F I P++G+I V T L Sbjct: 493 VEVYFPENNIPGERVATVLATDADSGKNAEIAYSL--DSSVMGIFAIDPDSGDILVNTVL 550 Query: 571 DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630 DREQ + YE KV A D+G P LQG+ TV+V V D NDNDPKFM + F V EN+ SP Sbjct: 551 DREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSP 610 Query: 631 VGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDG 690 VGMVTV+D DKG NA++ L +E++N F I+N TGTI S++SFDRE Q+TYTF++KAVDG Sbjct: 611 VGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDG 670 Query: 691 GVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNA 750 G PPRSA V++ V+DENDNAP +T P N S+ LL P + + V+ V A D D G+NA Sbjct: 671 GDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINA 730 Query: 751 ELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHL 810 +L YSI GGNP+ LF+I SG ++L ++ ++H+GLHRLVV+V+D G+P + T LVH+ Sbjct: 731 DLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 790 Query: 811 YVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIAL 870 +VNE+++N T +++ + SL PL DIAGDP YE SKQR +I+ GVVAG++ V L+I + Sbjct: 791 FVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILI 850 Query: 871 AVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDE 930 V+ RYCR + K+GY+AGKK+ +D + P+ K+ K K K K KS +P+ E Sbjct: 851 VVMARYCRSKN-KNGYEAGKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVE 908 Query: 931 AGLQKSLKFNLMSDAPGDSPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSAS 988 A +++ +++ DSP + + +N PGSPDL RHY+S+SPLP++QL PQSP+A Sbjct: 909 ASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAG 968 Query: 989 KKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQVGQPFQLSTPQPLPH 1048 KKHQ VQDLPPANTFVG GD S GS+ S+YS +TN +K QPF+ T + Sbjct: 969 KKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTN-----NKYSKQPFRRVTFSVVSQ 1023 Query: 1049 P 1049 P Sbjct: 1024 P 1024 >gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] Length = 1203 Score = 698 bits (1801), Expect = 0.0 Identities = 420/1006 (41%), Positives = 589/1006 (58%), Gaps = 50/1006 (4%) Query: 42 MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH--------LYKL- 92 +L AL+ L A ++Y + EE P N IG++ D + +Y+L Sbjct: 8 LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67 Query: 93 -EVG-APYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR 150 + G AP ++V TG+IFTT IDRE L + + C E EV I + N R Sbjct: 68 SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI---LPNDFFR 124 Query: 151 LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG 210 L++ +I V+D NDN P F SPVI ++IPENT I S FPIP A+D D G NGV YEL G Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184 Query: 211 PEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269 Q +FGL + E E EK PQLIV NLDRE+ D+Y + IKV+DGG+P ++S+A+L+VT Sbjct: 185 ---QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241 Query: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH-QAPEVVRR 328 V D NDN P F+ E + EN+P+G SVIQ+ A D+D G+NAEI Y F Q +R Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301 Query: 329 LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388 L L+ TGLITVQ +DRE+ + + +VLA D + P ARA V + V D+NDN P I+ Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNID 359 Query: 389 IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448 +R I ++ +G +SE T +AL+ VSD+D N V C + +VPF L+ + Sbjct: 360 LRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417 Query: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508 +Y L+T++ LDYE K+++ +IVA DSG P L+ T ++V++ D NDN P+F Q Sbjct: 418 ------QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471 Query: 509 SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKT 568 V E++ ENN+ G + I+A+D DSG NA++VY L P + F + +TG + Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---FFDLDRKTGVLTASR 528 Query: 569 SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628 DRE++E + V A D G+P LQ A V+V VLD NDN PKF + + F V EN+P Sbjct: 529 VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588 Query: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688 S VG++TV D D GEN V LS+ DN +FV+ +G I S++SFDREQQS+YTF +KA Sbjct: 589 STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648 Query: 689 DGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747 DGG PPRS+ VTINV+D NDN+P I+ PSNTS KL+ G V++V A D D+G Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708 Query: 748 VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGT-A 806 +NAEL Y+I GN GLF+I +G ITLE++ GLHRLVV +SD G P T Sbjct: 709 MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768 Query: 807 LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866 LV LYVN+T N + + L+ +++TPLD +I + +++ I+ ++AG + V + Sbjct: 769 LVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIV 828 Query: 867 LIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKP----- 921 +I + VLVR CR S ++A ++ + P+ + + K K KK KSPK Sbjct: 829 VIFVTVLVR-CRH---ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNF 884 Query: 922 VKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHL-------PLNYPPGSPDLGRHYRSNSP 974 V E + + + + + + A + I P + P SPDL +HY+S SP Sbjct: 885 VTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASP 944 Query: 975 LPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020 P+ L+P +P + KKH V+Q+LP NTFVG DT S S SD+ Sbjct: 945 QPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDH 990 >gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] Length = 1237 Score = 698 bits (1801), Expect = 0.0 Identities = 420/1006 (41%), Positives = 589/1006 (58%), Gaps = 50/1006 (4%) Query: 42 MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH--------LYKL- 92 +L AL+ L A ++Y + EE P N IG++ D + +Y+L Sbjct: 8 LLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLV 67 Query: 93 -EVG-APYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPR 150 + G AP ++V TG+IFTT IDRE L + + C E EV I + N R Sbjct: 68 SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI---LPNDFFR 124 Query: 151 LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG 210 L++ +I V+D NDN P F SPVI ++IPENT I S FPIP A+D D G NGV YEL G Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184 Query: 211 PEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269 Q +FGL + E E EK PQLIV NLDRE+ D+Y + IKV+DGG+P ++S+A+L+VT Sbjct: 185 ---QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241 Query: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH-QAPEVVRR 328 V D NDN P F+ E + EN+P+G SVIQ+ A D+D G+NAEI Y F Q +R Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301 Query: 329 LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388 L L+ TGLITVQ +DRE+ + + +VLA D + P ARA V + V D+NDN P I+ Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNID 359 Query: 389 IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448 +R I ++ +G +SE T +AL+ VSD+D N V C + +VPF L+ + Sbjct: 360 LRYI--ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417 Query: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508 +Y L+T++ LDYE K+++ +IVA DSG P L+ T ++V++ D NDN P+F Q Sbjct: 418 ------QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471 Query: 509 SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKT 568 V E++ ENN+ G + I+A+D DSG NA++VY L P + F + +TG + Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---FFDLDRKTGVLTASR 528 Query: 569 SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628 DRE++E + V A D G+P LQ A V+V VLD NDN PKF + + F V EN+P Sbjct: 529 VFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKY 588 Query: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688 S VG++TV D D GEN V LS+ DN +FV+ +G I S++SFDREQQS+YTF +KA Sbjct: 589 STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648 Query: 689 DGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747 DGG PPRS+ VTINV+D NDN+P I+ PSNTS KL+ G V++V A D D+G Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708 Query: 748 VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGT-A 806 +NAEL Y+I GN GLF+I +G ITLE++ GLHRLVV +SD G P T Sbjct: 709 MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768 Query: 807 LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866 LV LYVN+T N + + L+ +++TPLD +I + +++ I+ ++AG + V + Sbjct: 769 LVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIV 828 Query: 867 LIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSKSPKP----- 921 +I + VLVR CR S ++A ++ + P+ + + K K KK KSPK Sbjct: 829 VIFVTVLVR-CRH---ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNF 884 Query: 922 VKPVEDEDEAGLQKSLKFNLMSDAPGDSPRIHL-------PLNYPPGSPDLGRHYRSNSP 974 V E + + + + + + A + I P + P SPDL +HY+S SP Sbjct: 885 VTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASP 944 Query: 975 LPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDY 1020 P+ L+P +P + KKH V+Q+LP NTFVG DT S S SD+ Sbjct: 945 QPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDH 990 >gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] Length = 1337 Score = 663 bits (1710), Expect = 0.0 Identities = 412/1056 (39%), Positives = 586/1056 (55%), Gaps = 59/1056 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL A Y + EE P N LIG L D + + Sbjct: 3 LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 63 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 177 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 234 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 352 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+T LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 410 PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A DADSG NA++ Y L P+ + F++ TG Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + YNF V E Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I PSN S++L+ P T G V QV A Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S + P+ + + IL VAG Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q K+ + P P + K K KK K SPK Sbjct: 822 ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879 Query: 921 PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 + +D D G + L +L G + P + P SPDL RHY Sbjct: 880 NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKY 1029 +S SP P+ Q+QP++P + KH ++Q+LP NTFV D+ S S SD Y + Y Sbjct: 940 KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVAC-DSISKCSSSSSD-PYSVSDCGY 996 Query: 1030 PSKQVGQPFQLSTPQPLPH------PYHGAIWTEVW 1059 P P + T P+ P + E+W Sbjct: 997 PVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTMEIW 1032 >gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] Length = 1347 Score = 663 bits (1710), Expect = 0.0 Identities = 412/1056 (39%), Positives = 586/1056 (55%), Gaps = 59/1056 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL A Y + EE P N LIG L D + + Sbjct: 3 LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 63 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 177 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 234 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 352 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+T LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 410 PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A DADSG NA++ Y L P+ + F++ TG Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + YNF V E Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I PSN S++L+ P T G V QV A Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S + P+ + + IL VAG Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q K+ + P P + K K KK K SPK Sbjct: 822 ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879 Query: 921 PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 + +D D G + L +L G + P + P SPDL RHY Sbjct: 880 NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKY 1029 +S SP P+ Q+QP++P + KH ++Q+LP NTFV D+ S S SD Y + Y Sbjct: 940 KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVAC-DSISKCSSSSSD-PYSVSDCGY 996 Query: 1030 PSKQVGQPFQLSTPQPLPH------PYHGAIWTEVW 1059 P P + T P+ P + E+W Sbjct: 997 PVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTMEIW 1032 >gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo sapiens] Length = 1021 Score = 660 bits (1703), Expect = 0.0 Identities = 401/1012 (39%), Positives = 570/1012 (56%), Gaps = 51/1012 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL A Y + EE P N LIG L D + + Sbjct: 3 LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 63 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 177 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 234 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 352 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+T LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 410 PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A DADSG NA++ Y L P+ + F++ TG Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + YNF V E Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I PSN S++L+ P T G V QV A Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S + P+ + + IL VAG Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q K+ + P P + K K KK K SPK Sbjct: 822 ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879 Query: 921 PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 + +D D G + L +L G + P + P SPDL RHY Sbjct: 880 NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021 +S SP P+ Q+QP++P + KH ++Q+LP NTFV + S YS Sbjct: 940 KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVACDSISKCSSSSSDPYS 990 >gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo sapiens] Length = 1025 Score = 660 bits (1703), Expect = 0.0 Identities = 401/1012 (39%), Positives = 570/1012 (56%), Gaps = 51/1012 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL A Y + EE P N LIG L D + + Sbjct: 3 LLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQ 62 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 63 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 116 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 176 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 177 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 233 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 234 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 294 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 351 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 352 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+T LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 410 PVFSN------QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A DADSG NA++ Y L P+ + F++ TG Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGM 521 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + YNF V E Sbjct: 522 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 641 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I PSN S++L+ P T G V QV A Sbjct: 642 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 702 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 761 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S + P+ + + IL VAG Sbjct: 762 LFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 821 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q K+ + P P + K K KK K SPK Sbjct: 822 ITVVVVIFITAVVR-CRQAPHLKAAQK-NKQNSEWATPNPENRQMIMMKKKKKKKKHSPK 879 Query: 921 PV---------KPVEDEDEAG--LQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 + +D D G + L +L G + P + P SPDL RHY Sbjct: 880 NLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 939 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021 +S SP P+ Q+QP++P + KH ++Q+LP NTFV + S YS Sbjct: 940 KSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFVACDSISKCSSSSSDPYS 990 >gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] Length = 1340 Score = 654 bits (1687), Expect = 0.0 Identities = 399/1012 (39%), Positives = 571/1012 (56%), Gaps = 51/1012 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL+ A Y + EE P N LIG+L D + + Sbjct: 35 LLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQ 94 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 95 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 148 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 149 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 208 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 209 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 265 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 266 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 326 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 383 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 384 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 441 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+ LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 442 PVFSN------QFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A+DADSG NAE+ Y L P+ + F++ TG Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGM 553 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + Y F V E Sbjct: 554 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 614 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 673 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I P N S++L+ P T G V QV A Sbjct: 674 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 734 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 793 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S++ P+ + + IL VAG Sbjct: 794 LFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 853 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q + + P P + K K KK K SPK Sbjct: 854 ITVVVVIFITAVVR-CRQAPHLKAAQK-NMQNSEWATPNPENRQMIMMKKKKKKKKHSPK 911 Query: 921 ----PVKPVE-------DEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 V +E D D + L +L G + P + P SPDL RHY Sbjct: 912 NLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 971 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021 +S SP P+ Q+QP++P + KH ++Q+LP NTFV ++ S YS Sbjct: 972 KSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFVACDSISNCSSSSSDPYS 1022 >gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] Length = 1048 Score = 654 bits (1687), Expect = 0.0 Identities = 399/1012 (39%), Positives = 571/1012 (56%), Gaps = 51/1012 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL+ A Y + EE P N LIG+L D + + Sbjct: 35 LLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQ 94 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 95 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 148 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 149 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 208 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 209 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 265 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 266 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 325 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 326 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 383 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 384 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 441 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+ LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 442 PVFSN------QFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A+DADSG NAE+ Y L P+ + F++ TG Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGM 553 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + Y F V E Sbjct: 554 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 614 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 673 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I P N S++L+ P T G V QV A Sbjct: 674 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 734 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 793 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S++ P+ + + IL VAG Sbjct: 794 LFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 853 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q + + P P + K K KK K SPK Sbjct: 854 ITVVVVIFITAVVR-CRQAPHLKAAQK-NMQNSEWATPNPENRQMIMMKKKKKKKKHSPK 911 Query: 921 ----PVKPVE-------DEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 V +E D D + L +L G + P + P SPDL RHY Sbjct: 912 NLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 971 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021 +S SP P+ Q+QP++P + KH ++Q+LP NTFV ++ S YS Sbjct: 972 KSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFVACDSISNCSSSSSDPYS 1022 >gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] Length = 1037 Score = 654 bits (1687), Expect = 0.0 Identities = 399/1012 (39%), Positives = 571/1012 (56%), Gaps = 51/1012 (5%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGH-------- 88 LL + + A+LL+ A Y + EE P N LIG+L D + + Sbjct: 24 LLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQ 83 Query: 89 ---LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 +YK P +R++ TG+IFTT IDRE L C + C E EV+I + Sbjct: 84 FKLVYKTG-DVPLIRIEEDTGEIFTTGARIDREKL--CAGIPRDEHCFYEVEVAI---LP 137 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + RL++ + ++DINDN P F + VI ++IPEN+ I S + +P A D D G NGV +Y Sbjct: 138 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNY 197 Query: 206 ELQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264 EL ++Q +FGL V E E +K PQLIV LDRE D+Y + +KV+DGG P R+S+A Sbjct: 198 ELI---KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTA 254 Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-AP 323 +L+V+V DTNDN P F+ E + EN+P+G SV Q+ A D+D G NA+I ++F Sbjct: 255 ILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 314 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + RRL L+ TGLIT++ P+DRE+ + VLA D G P ARA V+V V D+NDN Sbjct: 315 NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDN 372 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P+I+IR I V + +SE++ T +AL+ V+D+D N VTC ++PF+LR Sbjct: 373 VPSIDIRYI--VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 430 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++ L+ LDYE K+Y I+++A D+G PPL+ + L ++V D NDNA Sbjct: 431 PVFSN------QFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 PVFTQS V+ PENN PG + +++A+DADSG NAE+ Y L P+ + F++ TG Sbjct: 485 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGM 542 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + V LDRE+ + Y ++A D G P L TV V+++D NDN P F + Y F V E Sbjct: 543 LTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 602 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 N+P VG++TV D D G+N+ V LS+ +N DF I + TG I ++SFDRE+Q +YTF Sbjct: 603 NLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTF 662 Query: 684 QLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAE 742 +KA DGG RS+ VTINV+D NDN P +I P N S++L+ P T G V QV A Sbjct: 663 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 722 Query: 743 DFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802 D D+G+NAE+ YSI GGN LF I +G ITL ++ + GLHR++VK +D G+P Sbjct: 723 DNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDS 782 Query: 803 -YGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGV 861 + +V+L+VNE++ N TL+ L+ S++ P+ + + IL VAG Sbjct: 783 LFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGT 842 Query: 862 VAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKGNKSKGKKSK-SPK 920 + V ++I + +VR CRQ Q + + P P + K K KK K SPK Sbjct: 843 ITVVVVIFITAVVR-CRQAPHLKAAQK-NMQNSEWATPNPENRQMIMMKKKKKKKKHSPK 900 Query: 921 ----PVKPVE-------DEDEAGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHY 969 V +E D D + L +L G + P + P SPDL RHY Sbjct: 901 NLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHY 960 Query: 970 RSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGTGDTTSTGSEQYSDYS 1021 +S SP P+ Q+QP++P + KH ++Q+LP NTFV ++ S YS Sbjct: 961 KSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFVACDSISNCSSSSSDPYS 1011 >gi|190194360 protocadherin 20 [Homo sapiens] Length = 951 Score = 436 bits (1120), Expect = e-122 Identities = 300/854 (35%), Positives = 438/854 (51%), Gaps = 68/854 (7%) Query: 21 PRMEHLR-HSPGPGGQRLLLPSMLLALLLL----LAPSPGHATRVVYKVPEEQPPNTLIG 75 PR++ R H P LP + L L + S AT ++Y + E P LIG Sbjct: 24 PRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIG 83 Query: 76 SLAADY-------GFPDVGHLYKLEVGAP-----------------YLRVDGKTGDIFTT 111 SLA D G PD GA Y+ +D ++G++ T+ Sbjct: 84 SLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTS 143 Query: 112 ETSIDREGL------------RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159 IDRE L + P D C+L +V + + R ++ +I ++ Sbjct: 144 AQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLV---LPQEYFRFVKVKIAIR 200 Query: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFG 218 DINDN P F I++ +PEN + + I A D D G NGV +Y L + +F Sbjct: 201 DINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL---DYHGMFT 257 Query: 219 LQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNA 277 L V E++ E+ P LIVMG LDRE D Y I +DGGSPP SA L + + D NDN Sbjct: 258 LDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNC 317 Query: 278 PKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNT 336 P F + N+ +G + V+A D D G NA+I Y++ Q P+ + L LD NT Sbjct: 318 PLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENT 377 Query: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396 G+I + + L + + ++LA G P A +V++ + P I R I Sbjct: 378 GVIKLFSKIGGSVLESHKLTILANGPGCIPAVITA--LVSIIKVIFRPPEIVPRYIA--N 433 Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456 DG+ + E T +A + RD V C + G+ PF+L ++ Y Sbjct: 434 EIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRLSPYKPYNNE----Y 487 Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516 L+TT P+DYE + Y + +VA +S + +KVQ++D NDNAP+F Q + E+ Sbjct: 488 LLETTKPMDYELQQFYEVAVVAWNSEGFHVKRV--IKVQLLDDNDNAPIFLQPLIELTIE 545 Query: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576 ENN P + ++ A+DADS ++ Y L P+ A F++ TG + V T LDRE++E Sbjct: 546 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 603 Query: 577 SYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTV 636 Y V A D G P + ATV + VLD NDN P+F+ ++F V EN P +G+++V Sbjct: 604 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 663 Query: 637 IDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRS 696 D D G N V LSV + FVI G G + + +S DREQQS+YT ++AVDGG P S Sbjct: 664 TDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALS 723 Query: 697 AYVGVTINVLDENDNAPYITAP-SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755 + +TI +LD NDN P + P SN S+ L+ P T G V++V A D D+G+NA + YS Sbjct: 724 STAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYS 783 Query: 756 IAG--GNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP-PRYGTALVHLYV 812 I G G F+I +G ITLE+ + + +GLHRL+VKVSD G P P + T +V+L+V Sbjct: 784 IIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFV 843 Query: 813 NETLANRTLLETLL 826 N+T++N + +E+LL Sbjct: 844 NDTVSNESYIESLL 857 >gi|94538350 protocadherin 17 precursor [Homo sapiens] Length = 1159 Score = 353 bits (906), Expect = 5e-97 Identities = 245/686 (35%), Positives = 351/686 (51%), Gaps = 71/686 (10%) Query: 62 YKVPEEQPPNTLIGSLAADY----GFPDV----------GHLYKLEVGAPYLR-VDGKTG 106 Y VPEEQ T+IG++ D G P G LE AP+L VD +G Sbjct: 23 YSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSG 82 Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTP 166 ++T + IDRE L C++ C L EV D + ++E+QDINDN P Sbjct: 83 LLYTKQR-IDRESL--CRHNAK---CQLSLEVFAND------KEICMIKVEIQDINDNAP 130 Query: 167 NFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQV-AEDQ 225 +F+S I + I EN G+ FP+ A D DAG NG+ +Y L LFGL V + Sbjct: 131 SFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHG--LFGLDVKSRGD 188 Query: 226 EEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSY 285 K P+L++ LDRE+ + + L + DGG PPR+++ + V V+D+NDN+P FE PSY Sbjct: 189 GTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSY 248 Query: 286 EAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNTGLITVQGP 344 EL EN+P+G VI + A D+D+G N E+ Y+F P+ VR L +D TGLI V+G Sbjct: 249 LVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGN 308 Query: 345 VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANI 404 +D E+ L V A+D G NP A +V V + D NDNAP+ IG V+ + G + Sbjct: 309 LDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPS-----IGFVSVRQGA--L 361 Query: 405 SEDVAEETAVALVQVSDRDEGENAAVTCVV---------------AGDVPFQLRQASETG 449 SE T +ALV+V+DRD G+N + C V G VPF+L + Sbjct: 362 SEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEE----- 416 Query: 450 SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQS 509 + Y + T PLD E +Y + IVA D G+PPL+ST S ++++D NDN P FT+ Sbjct: 417 -NYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKG 475 Query: 510 VTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP----EPAAKGLFTISPETGEIQ 565 + + ENN PGE + + A D D G N + YS+ P + + +++P G I Sbjct: 476 LYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIY 535 Query: 566 VKTSLDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCNDNDPKFMLSGYNFSVME- 623 S + EQ +++E KV+A D G+P+ L+ ATV V VLD NDN P +L E Sbjct: 536 ALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAEL 595 Query: 624 NMPALSPVG----MVTVIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSFDREQ 677 +P + +G V +D D GE+ ++ + N D F I +G I + F + Sbjct: 596 QVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDV 655 Query: 678 QSTYTFQLKAVDGGVPPRSAYVGVTI 703 +K D G P SA + I Sbjct: 656 TPVVELVVKVTDHGKPTLSAVAKLII 681 Score = 218 bits (556), Expect = 2e-56 Identities = 181/566 (31%), Positives = 254/566 (44%), Gaps = 41/566 (7%) Query: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324 +++V + D NDNAP F E ++SEN+ G A+D D G N Y + Sbjct: 117 MIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH 176 Query: 325 VVRRLLRLDRNTGL----ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDM 380 + L R G + +Q +DRE + + A D G P+SA Q+ V V D Sbjct: 177 GLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDS 236 Query: 381 NDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPF 440 NDN+P E + + E+ T V + +D DEG N V + VP Sbjct: 237 NDNSPVFEAPSY--------LVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPD 288 Query: 441 QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVN 500 ++R E S K ++ LDYE+ I++ A D G P+ + + V+++D N Sbjct: 289 RVR---ELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRN 345 Query: 501 DNAP-VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559 DNAP + SV + A E PG VIA + +D DSG N +L + G + Sbjct: 346 DNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGG 405 Query: 560 ETGEIQVKTS--------------LDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605 G + K LDRE ++ Y + +VA D GSP L T + + +LD Sbjct: 406 PGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDE 465 Query: 606 NDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-GD-----FV 659 NDN P+F Y V EN +G V D D G+N V S+ + GD +V Sbjct: 466 NDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYV 525 Query: 660 IQNGT-GTILSSLSFDREQQSTYTFQLKAVDGGVPPR-SAYVGVTINVLDENDNAPYITA 717 N T G I + SF+ EQ + F++ A D G P + V + VLD NDNAP I Sbjct: 526 SVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVL 585 Query: 718 PS--NTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI 774 P+ N + +L P+ LG VS V A D D G + L Y I GN LF+I SG I Sbjct: 586 PTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEI 645 Query: 775 TLEKEIERRHHGLHRLVVKVSDRGKP 800 + LVVKV+D GKP Sbjct: 646 RTLHPFWEDVTPVVELVVKVTDHGKP 671 Score = 189 bits (481), Expect = 9e-48 Identities = 155/520 (29%), Positives = 228/520 (43%), Gaps = 56/520 (10%) Query: 329 LLRLDRNTGLITVQGPVDREDLST------LRFSVLAKDRGTNPKSARAQVVVTVKDMND 382 LL +D ++GL+ + +DRE L L V A D+ + V ++D+ND Sbjct: 74 LLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEI------CMIKVEIQDIND 127 Query: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442 NAP+ I + +ISE+ A T L D D GEN T ++ D Sbjct: 128 NAPSFSSDQIEM--------DISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLF 179 Query: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502 ++ D K L LD E+ +T+ + A+D G PP S+T + V+V+D NDN Sbjct: 180 GLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDN 239 Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP--EPAAKGLFTISPE 560 +PVF V PEN G V+ ++ A+DAD G N E++YS + LF+I P+ Sbjct: 240 SPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPK 299 Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNF 619 TG I+VK +LD E+ E+ V A D G + V V ++D NDN P +S Sbjct: 300 TGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQG 359 Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD--------------FVIQNGTG 665 ++ E P + + +V V D D G+N Q+Q V G F ++ Sbjct: 360 ALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYD 419 Query: 666 ---TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTS 722 T+++ DRE Q Y + A DGG PP ++ I +LDENDN P T Sbjct: 420 NFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFT---KGL 476 Query: 723 HKLLTPQTRL-GETVSQVAAEDFDSGVNAELIYSIAGG-----NPYGLFQIGSHSGAITL 776 + L + + GE + V A+D D G N + YSI + Y + +GAI Sbjct: 477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYA 536 Query: 777 EKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETL 816 + V D G P HL N T+ Sbjct: 537 LRSFNFEQTKAFEFKVLAKDSGAP-------AHLESNATV 569 Score = 113 bits (283), Expect = 8e-25 Identities = 95/327 (29%), Positives = 136/327 (41%), Gaps = 37/327 (11%) Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP--------------- 547 AP T + PE G VI I G +A L L P Sbjct: 13 APALTLKNLNYSVPEEQGAGTVIGNI-------GRDARLQPGLPPAERGGGGRSKSGSYR 65 Query: 548 --EPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605 E +A L + ++G + K +DRE + K + + + + V + D Sbjct: 66 VLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDI 125 Query: 606 NDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENA-QVQLSVEQDNGDF---VIQ 661 NDN P F + EN + + + D D GEN + L D+G F V Sbjct: 126 NDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKS 185 Query: 662 NGTGTILSSL----SFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITA 717 G GT L + DREQQ+ +T L A+DGG PPRSA V + + V+D NDN+P A Sbjct: 186 RGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEA 245 Query: 718 PSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNP---YGLFQIGSHSGAI 774 PS L LG V + A D D G N E++YS + P LF I +G I Sbjct: 246 PSYLVE--LPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLI 303 Query: 775 TLEKEIERRHHGLHRLVVKVSDRGKPP 801 ++ ++ +G+ + V+ D G P Sbjct: 304 RVKGNLDYEENGMLEIDVQARDLGPNP 330 Score = 44.3 bits (103), Expect = 6e-04 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 10/130 (7%) Query: 701 VTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGN 760 + + + D NDNAP + S+ ++ G +A D D+G N Y + + Sbjct: 118 IKVEIQDINDNAPSFS--SDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDD 175 Query: 761 PYGLFQI-------GSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813 +GLF + G+ + ++K ++R H LV+ D G+PPR T +++ V Sbjct: 176 -HGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVI 234 Query: 814 ETLANRTLLE 823 ++ N + E Sbjct: 235 DSNDNSPVFE 244 >gi|16933557 dachsous 1 precursor [Homo sapiens] Length = 3298 Score = 348 bits (894), Expect = 1e-95 Identities = 264/784 (33%), Positives = 379/784 (48%), Gaps = 47/784 (5%) Query: 29 SPGPGGQRLLLPSMLLALLLLLAPSPG---HATRVVYKVPEEQPPNTLIGSLAADYGFPD 85 SP P LLLP +LL LLLL A PG A + ++ EEQP TLIG ++A G P Sbjct: 16 SPRP---HLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISA--GLP- 69 Query: 86 VGHLYKLEVGAPYLR-VDGKTGDIFTTETSIDRE-GLRECQNQLPGDPCILEFEVSITDL 143 AP + + + G T+ +ID G+ L + T + Sbjct: 70 ------AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQ---RDRYRFTAV 120 Query: 144 VQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203 +G+ +E + V DIND+ P F L +PE+T G+ +P+ A D DAG G Sbjct: 121 TPDGAT--VEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQ 178 Query: 204 SYELQAGPEAQELFGLQVAEDQEEKQ-PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262 Y L +G A E F L+ + P+L+V G LDRE Y L ++ DGGSPPR + Sbjct: 179 GYAL-SGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRA 237 Query: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322 ALL VT+LD ND+AP F + Y A +SE+ G V+QV A+D+D G N + Y ++ Sbjct: 238 QALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 297 Query: 323 PEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382 +D +TGL+ ++ P+D E V A+D G +P+ A V V V+D ND Sbjct: 298 QSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 357 Query: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQ 441 N P++ + + DG +SE VA + VSD D+G+ A V + G+ F Sbjct: 358 NQPSMTV----IFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFA 413 Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501 L + Y + LD E+ Y + + A DSG+PPL + + + V DVND Sbjct: 414 L------STQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 467 Query: 502 NAPVF-TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560 NAP F Q PE PG + +TA D D G+N ++ YSL P A F+I P Sbjct: 468 NAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAP-GAHTHWFSIDPT 526 Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620 +G I SLD E +L VVA D G P L +ATV V + D NDN+P+F + YN S Sbjct: 527 SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNAS 586 Query: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTILSSLSFDR 675 + E + VT D D G + S+ G F I +G + ++ + DR Sbjct: 587 LPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDR 646 Query: 676 EQ-QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGE 734 +Q S++ F + AVDGG YV V ++ DENDN P + ++ Q+ G Sbjct: 647 DQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFYPREYAAS--ISAQSPPGT 702 Query: 735 TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794 V ++ A D D G + L Y I GN LF + SG +T+ + RR + + +L + Sbjct: 703 AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGA 762 Query: 795 SDRG 798 D G Sbjct: 763 EDGG 766 Score = 255 bits (651), Expect = 2e-67 Identities = 276/1034 (26%), Positives = 422/1034 (40%), Gaps = 120/1034 (11%) Query: 53 SPGHATRVVYKVPEEQPPN-TLIGSLAADYGFPDVGHL----YKLEVGAP-YLRVDGKTG 106 +P A+ ++PE+QPP + +A D PD+G Y+L G + R+ TG Sbjct: 1543 APVFASPSRVRLPEDQPPGPAALHVVARD---PDLGEAARVSYRLASGGDGHFRLHSSTG 1599 Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI---EVQDIND 163 + +DRE E V +GSP Q+ V D+ND Sbjct: 1600 ALSVVRP-LDREQRAE--------------HVLTVVASDHGSPPRSATQVLTVSVADVND 1644 Query: 164 NTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAE 223 P F ++ + EN G+ A+D D G NG +Y G + E F L Sbjct: 1645 EAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY----GGVSSESFSL---- 1696 Query: 224 DQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERP 283 + L + LDRE + +LT+ QD GSPP+ + +RV V D ND+AP F Sbjct: 1697 --DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1754 Query: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343 E+ E ++ ++A+D D GAN +++Y LD +G Sbjct: 1755 HLSLEVPEGQD-PQTLTMLRASDPDVGANGQLQYRILDGDP--SGAFVLDLASGEFGTMR 1811 Query: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403 P+DRE + + A+D G SA + VTV D ND+AP + + Sbjct: 1812 PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV--------E 1863 Query: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP 463 + EDV T + +Q D D G N VT + +G L+T Sbjct: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE-------LRTAAA 1916 Query: 464 LDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPEN---- 518 LD E+ YT + AVD PLS+T S+ + V DVND+AP F S + P Sbjct: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976 Query: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578 + P +A + A D D+G+NA ++Y L P T+ TGEI+V S Sbjct: 1977 STPTLALATLRAEDRDAGANASILYRLAGTPPPGT--TVDSYTGEIRVARSPVALGPRDR 2034 Query: 579 ELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVID 638 L +VA D G P+ T ++V + + P+F + ++ EN P +P+ + Sbjct: 2035 VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVH 2094 Query: 639 GDKGENAQVQLSVEQDN--GDFVIQNGTG--TILSSLSFDREQQSTYTFQLKAVDGGVPP 694 G N + S+ N G F IQ TG T+ S+ D E L+A GG Sbjct: 2095 AG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA-- 2151 Query: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAELI 753 A+ +T+ + D NDNAP P + P++R L + QV A+D D G ++ Sbjct: 2152 -FAFTVLTLTLQDANDNAPRFLRPHYVA---FLPESRPLEGPLLQVEADDLDQGSGGQIS 2207 Query: 754 YSIAGGNPY-GLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812 YS+A P GLF + +G IT ++R RLV+ +DRG P G+A + + V Sbjct: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMV 2267 Query: 813 NETLANRTLL----------ETLLGHSLDTPLDIDIAGDP----EYERSKQRGNILFGVV 858 +T NR + + LLG + D+ P S + G Sbjct: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRY 2327 Query: 859 AGVVAVALLIALAVLVRYCRQREAKSGYQAGKKE----TKDLYAPKPSGKASKGNKSKGK 914 G V++ + RY Q A G G+ +D+ P+ S + Sbjct: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE 2387 Query: 915 KSKSPKPVKPVEDED-EAGLQKSLKFNLMSDAPGDSPRIH----------LPLNYPPG-- 961 + + V D ++G + ++L S A G S + + L + Sbjct: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447 Query: 962 ------SPDLGRHYRSNSPLPSIQLQPQ---SPSASKKH---QVVQDLPPANTFVGTGDT 1009 + D G R+ +QLQ Q +PS + H V +DLPP +T + T Sbjct: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507 Query: 1010 TSTGSEQYS--DYS 1021 + GS ++ DYS Sbjct: 2508 DADGSRSHAAVDYS 2521 Score = 253 bits (645), Expect = 9e-67 Identities = 234/785 (29%), Positives = 347/785 (44%), Gaps = 84/785 (10%) Query: 19 GPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATR-----VVYKVPEEQPPNTL 73 GPP + GPGG + LL + + + HA + +PE P Sbjct: 1399 GPPWRALTVRAEGPGGAG----ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAA 1454 Query: 74 IGSLAA---DYGFPDVGHLYKL---EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQL 127 + + A D P+ Y+L E P LR+D +TG + + +DRE Sbjct: 1455 LYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDRETT------- 1506 Query: 128 PGDPCILEFEVSITDLVQNGSPRL---LEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184 P +L V TD N S R + ++ V D NDN P FASP + +PE+ G Sbjct: 1507 ---PALLLL-VEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPG 1561 Query: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244 +A D D G SY L +G + F L + L V+ LDRE+ Sbjct: 1562 PAALHVVARDPDLGEAARVSYRLASGGDGH--FRLHSSTGA------LSVVRPLDREQRA 1613 Query: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304 + LT+ D GSPPR+++ +L V+V D ND AP F++ Y L EN+P G S++ ++A Sbjct: 1614 EHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRA 1673 Query: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364 D D GAN ++ Y V LD +TG++T +DRE+ + +V A+DRG+ Sbjct: 1674 TDPDVGANGQVTY-----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGS 1728 Query: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE---ETAVALVQVSD 421 P+ V V V+D ND+APT G A++S +V E + +++ SD Sbjct: 1729 PPQLTHVTVRVAVEDENDHAPTF------------GSAHLSLEVPEGQDPQTLTMLRASD 1776 Query: 422 RDEGENAAVTCVVAGDVPFQLRQASETGS---DSKKKYFLQTTTPLDYEKVKDYTIEIVA 478 D G N G + +++ +G+ D F T PLD E + + I A Sbjct: 1777 PDVGAN--------GQLQYRILDGDPSGAFVLDLASGEF-GTMRPLDREVEPAFQLRIEA 1827 Query: 479 VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538 D G P LS+T L V V+D ND+AP F V PE+ G ++ ++ A D D+G+N Sbjct: 1828 RDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887 Query: 539 AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTAT 597 + Y L A G F + P +GE++ +LDREQ SY V A D + L T + Sbjct: 1888 GHVTYYLGAGTA--GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945 Query: 598 VLVNVLDCNDNDPKFMLSGYNFSVMENMPALS----PVGMVTVIDGDKGENAQV--QLSV 651 V + V D ND+ P F S + P+ S + + D D G NA + +L+ Sbjct: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAG 2005 Query: 652 EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711 G + + TG I + S + A D G P RSA + + + E + Sbjct: 2006 TPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAER 2064 Query: 712 APYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHS 771 P P +S + G + A G N + YSI GN G F I + Sbjct: 2065 GPRF--PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPST 2121 Query: 772 GAITL 776 GAIT+ Sbjct: 2122 GAITV 2126 Score = 242 bits (618), Expect = 1e-63 Identities = 245/878 (27%), Positives = 380/878 (43%), Gaps = 133/878 (15%) Query: 90 YKLEVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146 Y L P VD TG I TT +DRE E + L Sbjct: 2208 YSLAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMA--------------TDR 2252 Query: 147 GSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203 GSP L+ + V D NDN P P L + E+ +GS +D D+GP V Sbjct: 2253 GSPALVGSATLTVMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSGP--VL 2309 Query: 204 SYELQ-AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262 Y L +GP+ G ++ + G LD E+ D Y L + DG P Sbjct: 2310 WYVLSPSGPQDPFSVGRYGG--------RVSLTGPLDFEQCDRYQLQLLAHDG---PHEG 2358 Query: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322 A L V V D NDNAP F + Y+ L E++P G +++ V A D D GAN I Y Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418 Query: 323 PEVVRRLLRLDRNTG-LITVQGPV--DREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKD 379 + +D N G L T+ G V + + + A+D G ++ARA V V ++D Sbjct: 2419 ADG----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474 Query: 380 MNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT--CVVAGD 437 ND+AP+ + + ++ED+ + + ++ +D D + A +++G+ Sbjct: 2475 QNDHAPSFTLSHYRVA--------VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN 2526 Query: 438 ------VPFQLRQASET-GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN 490 + +L +A E+ G + L PLD+E + Y + + A D G PP SS Sbjct: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586 Query: 491 SLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550 + V V+DVNDN PVFT++ V PE+ G + + ASDAD G + + +++ Sbjct: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP 2646 Query: 551 AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610 + GLF + +G +++ +LD E + ++L V AAD A V + V D ND+ P Sbjct: 2647 S-GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGP 2704 Query: 611 KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV------EQDNGDFVIQNGT 664 F L+ + SV EN P + V + IDGD G +++ S+ + F + + T Sbjct: 2705 AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSST 2764 Query: 665 GTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHK 724 G + + + FD E ++ + A D G SA V V++ V E++ P AP+ H Sbjct: 2765 GELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPA--FHF 2820 Query: 725 LLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI---- 780 + R G ++ V A D D G + ++YS+A +PY F I +GA+ L + Sbjct: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYLRVDSRAPG 2878 Query: 781 ----------ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSL 830 R L ++V RG P +A V + V+ T T LG + Sbjct: 2879 SGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDIT-------HTALGLAP 2931 Query: 831 DTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVR---YCRQREAKSGYQ 887 D L +L G VA + V +++ALA LV R R+A++ Sbjct: 2932 DLNL------------------LLVGAVAASLGVVVVLALAALVLGLVRARSRKAEA--- 2970 Query: 888 AGKKETKDLYAPKPSGK----ASKGNKSKGKKSKSPKP 921 AP P + AS + G++ SP P Sbjct: 2971 ----------APGPMSQAAPLASDSLQKLGREPPSPPP 2998 Score = 242 bits (617), Expect = 2e-63 Identities = 221/772 (28%), Positives = 337/772 (43%), Gaps = 62/772 (8%) Query: 59 RVVYKVPEEQPPNTLIGSLAADYGF--PDVGH----LYKLEVGAP--YLRVDGKTGDIFT 110 R +Y+ PE P L GS PD G Y L GA + +D +G I T Sbjct: 474 RQLYR-PEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSG-IIT 531 Query: 111 TETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDINDNTPN 167 T S+D E E Q QL I G P L + +QD+NDN P Sbjct: 532 TAASLDYE--LEPQPQL------------IVVATDGGLPPLASSATVSVALQDVNDNEPQ 577 Query: 168 FASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEE 227 F ++PE T G+ F A+D D+GP G+ SY L AG + ++ + Sbjct: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI----DA 633 Query: 228 KQPQLIVMGNLDRERW-DSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYE 286 + LDR++ S+D T+ DGG S ++V + D NDN P+F Y Sbjct: 634 HSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYA 691 Query: 287 AELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVD 346 A +S SP G +V++++A+D DQG++ + Y H L LD +GL+TV P+ Sbjct: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY--HILAGNSPPLFTLDEQSGLLTVAWPLA 749 Query: 347 REDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISE 406 R S ++ + A+D G A+V +++ P E + ++ E Sbjct: 750 RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE--------QLQYVFSVPE 801 Query: 407 DVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDY 466 DVA T+V +VQ + G A VT ++G P L LQT PLD Sbjct: 802 DVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVSG------LLQTLRPLDR 854 Query: 467 EKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIA 526 E + V SG PP + ++V + DVNDN+P F V P N PG I Sbjct: 855 ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY 914 Query: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAAD 586 + A D DSG N+ + ++L G FT+ P TG +++ L ++EL++ A D Sbjct: 915 TLRALDPDSGVNSRVTFTLLA--GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972 Query: 587 RGSPSLQGTATVLVNVLDCNDND--PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGEN 644 GSP + V V D P+F Y + A + V V D G Sbjct: 973 GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP- 1031 Query: 645 AQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---V 701 L+ E + F ++ +G + + DRE Q Y ++ AV G G V Sbjct: 1032 ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATV 1091 Query: 702 TINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAG-GN 760 +++L++N+++P ++ + + + G +V +V A D DSG N L YS+ Sbjct: 1092 RVSILNQNEHSPRLS--EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149 Query: 761 PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812 F+I +G +T + ++R ++L+V+V D G PPR T VH+ V Sbjct: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAV 1201 Score = 227 bits (579), Expect = 4e-59 Identities = 207/695 (29%), Positives = 300/695 (43%), Gaps = 65/695 (9%) Query: 134 LEFEVS-----ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNI-GSLF 187 L+FEVS + G+ + +QD NDN P F P +PE+ + G L Sbjct: 2132 LDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLL 2191 Query: 188 PIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD 247 + A D D G G SY L A A+ LF + + + LDRE W Sbjct: 2192 QVE-ADDLDQGSGGQISYSLAASQPARGLFHV------DPTTGTITTTAILDREIWAETR 2244 Query: 248 LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307 L + D GSP SA L V V+DTNDN P +P +E +SE++ +G + QV ND Sbjct: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDV 2303 Query: 308 DQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK 367 D G + +P + + R G +++ GP+D E + +LA D P Sbjct: 2304 DSGP----VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPH 2356 Query: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427 RA + V V+D+NDNAP + + E +A+ V +DRD G N Sbjct: 2357 EGRANLTVLVEDVNDNAPAF--------SQSLYQVMLLEHTPPGSAILSVSATDRDSGAN 2408 Query: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQT---TTPLDYEKVKDYTIEIVAVDSGNP 484 G + + L ++ S L T T L ++ + + A D G P Sbjct: 2409 --------GHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460 Query: 485 PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNAELVY 543 ++ ++ VQ+ D ND+AP FT S VA E+ PG + + A+DAD S S+A + Y Sbjct: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520 Query: 544 S-----------LEPEPAAKGLFTISP---ETGEIQVKTSLDREQRESYELKVVAADRGS 589 S LEP A G + P G + + LD E Y L V AADRG Sbjct: 2521 SIISGNWGRVFQLEPRLAEAGE-SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ 2579 Query: 590 PSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQL 649 P V V VLD NDN P F + Y +V E+ P + + V D D G + V+ Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639 Query: 650 SVE--QDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707 +V +G F + +GT+ + + D E Q+ + ++A D A VTI V D Sbjct: 2640 TVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD-PAGAHFALAPVTIEVQD 2698 Query: 708 ENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI--AGGNPYG-- 763 ND+ P P N + G V+ + A D D+G L YS+ AG P G Sbjct: 2699 VNDHGP--AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756 Query: 764 LFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798 F + S +G + + H RL+V +D G Sbjct: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2791 Score = 216 bits (551), Expect = 7e-56 Identities = 218/775 (28%), Positives = 331/775 (42%), Gaps = 59/775 (7%) Query: 51 APSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFT 110 AP+ G A + +VPE Q P TL A+D PDVG +L+ Y +DG F Sbjct: 1748 APTFGSA-HLSLEVPEGQDPQTLTMLRASD---PDVGANGQLQ----YRILDGDPSGAFV 1799 Query: 111 TETSIDREG-LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFA 169 + + G +R ++ +P + + D Q L + V D ND+ P F Sbjct: 1800 LDLASGEFGTMRPLDREV--EPAF-QLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856 Query: 170 SPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQ 229 P ++ +PE+ G+L A D DAG NG +Y L AG L E Sbjct: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLL--------EPSS 1908 Query: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSP-PRASSALLRVTVLDTNDNAPKFERPSYEAE 288 +L LDRE+ SY ++ DG + P +++ + +TV D ND+AP F Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLR 1968 Query: 289 LSENSPIGHS----VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITV-QG 343 L P + + ++A D D GANA I Y P + D TG I V + Sbjct: 1969 LPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV---DSYTGEIRVARS 2025 Query: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403 PV + F ++A D G +SA ++V ++ + P A Sbjct: 2026 PVALGPRDRVLF-IVATDLGRPARSATGVIIVGLQGEAERGPRFP--------RASSEAT 2076 Query: 404 ISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTT 462 I E+ T + + G N +T +++G+ TG+ + +++ Sbjct: 2077 IRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAIT-----VRSAE 2130 Query: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522 LD+E V ++ +SG + +L +Q D NDNAP F + PE+ Sbjct: 2131 GLDFE-VSPRLRLVLQAESGGAFAFTVLTLTLQ--DANDNAPRFLRPHYVAFLPESRPLE 2187 Query: 523 EVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKV 582 + ++ A D D GS ++ YSL A+GLF + P TG I LDRE L + Sbjct: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247 Query: 583 VAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642 +A DRGSP+L G+AT+ V V+D NDN P + + V E+ S + VT D D G Sbjct: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSG 2306 Query: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702 LS F + G + + D EQ Y QL A DG P +T Sbjct: 2307 PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLT 2363 Query: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPY 762 + V D NDNAP + + +L T G + V+A D DSG N + Y +A +P Sbjct: 2364 VLVEDVNDNAPAFS--QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLA--SPA 2419 Query: 763 GLFQIGSHSGAI-TLEKEIERRHHGLHR--LVVKVSDRGKPPRYGTALVHLYVNE 814 F + ++G + T+ + H G +V++ D G P R A VH+ + + Sbjct: 2420 DGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474 Score = 207 bits (528), Expect = 3e-53 Identities = 161/545 (29%), Positives = 239/545 (43%), Gaps = 26/545 (4%) Query: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343 S + ++ E P G + + A A + + Q V L +D ++G++ Sbjct: 46 SLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105 Query: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403 +DRE RF+ + P A +V V V D+ND+AP L Sbjct: 106 VLDREQRDRYRFTAVT------PDGATVEVTVRVADINDHAPAFPQARAAL--------Q 151 Query: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ-LRQASETGSDSKKKYFLQTTT 462 + E A T L D D G ++GD + R + G D L T Sbjct: 152 VPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTG 211 Query: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522 LD E Y +++ A D G+PP + L V ++D+ND+AP F QS E+ PG Sbjct: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271 Query: 523 EVIAEITASDADSGSNAELVYSLEPEPA-AKGLFTISPETGEIQVKTSLDREQRESYELK 581 + ++ ASDAD+G N + Y + + G F+I TG +Q++ LD EQR +EL Sbjct: 272 SPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331 Query: 582 VVAADRGSPSLQGTATVLVNVLDCNDNDPK----FMLSGYNFSVMENMPALSPVGMVTVI 637 V A D G+ G+A V V+V D NDN P F+ + + V E P V ++V Sbjct: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391 Query: 638 DGDKGENAQVQLSVEQDNGDFVIQNGTGTILS---SLSFDREQQSTYTFQLKAVDGGVPP 694 D D G+ A V +S+E G F + I + DRE++ Y ++ A D G PP Sbjct: 392 DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451 Query: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GETVSQVAAEDFDSGVNAELI 753 A ++V D NDNAP L P+ L G V +V A D D G N ++ Sbjct: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPL--PEVALPGSFVVRVTARDPDQGTNGQVT 509 Query: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813 YS+A G F I SG IT ++ +L+V +D G PP +A V + + Sbjct: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569 Query: 814 ETLAN 818 + N Sbjct: 570 DVNDN 574 Score = 197 bits (500), Expect = 6e-50 Identities = 190/682 (27%), Positives = 288/682 (42%), Gaps = 51/682 (7%) Query: 155 QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212 ++ VQD+ P F SP + +P T G+ A D GP +Y L A Sbjct: 985 RVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHL-AAEG 1040 Query: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP---RASSALLRVT 269 A FGL E + L V LDRE + Y L + G + +A +RV+ Sbjct: 1041 ASSPFGL------EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVS 1094 Query: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329 +L+ N+++P+ ++EN P G SV +V A D D G N + Y+ Q E + Sbjct: 1095 ILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED-SKA 1153 Query: 330 LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEI 389 R+ TG +T +DRE S+ + V +D G+ P+S V V V D+NDN+PT + Sbjct: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF-L 1212 Query: 390 RGIGLVTHQDGMA-NISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448 + G G+ + + V T V +Q D DEGEN + + G SE Sbjct: 1213 QASGAAG--GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGP-------GSEL 1263 Query: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV----------D 498 S L T PL + Y + + A D G+PP S++ L VQV+ D Sbjct: 1264 FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPD 1323 Query: 499 VNDNAPVFTQSVT-EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTI 557 + + P V V E +PG ++ + A + +G A L Y+L +G F + Sbjct: 1324 LAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVGGADPEGTFAL 1381 Query: 558 SPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGY 617 +G + + LD E + V A+ + V V V D N++ P F Sbjct: 1382 DAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPL 1441 Query: 618 NFSVMENMPALSPVGMVTVIDGD-KGENAQVQ---LSVEQDNGDFVIQNGTGTILSSLSF 673 ++ EN + + D D G N+ V+ L E + TG + + Sbjct: 1442 ALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGL 1501 Query: 674 DREQQSTYTFQLKAVD---GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT 730 DRE ++A D R+A V + V DENDNAP +PS L Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVR---LPEDQ 1558 Query: 731 RLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRL 790 G V A D D G A + Y +A G G F++ S +GA+++ + ++R H L Sbjct: 1559 PPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVL 1617 Query: 791 VVKVSDRGKPPRYGTALVHLYV 812 V SD G PPR T ++ + V Sbjct: 1618 TVVASDHGSPPRSATQVLTVSV 1639 Score = 189 bits (479), Expect = 2e-47 Identities = 199/774 (25%), Positives = 334/774 (43%), Gaps = 88/774 (11%) Query: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHL-YKLEVGAP--YLRVDGKTGDIFTTETSIDR 117 V+ VPE+ P T +G + A + + L G P +D +G + T +DR Sbjct: 796 VFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSG-LLQTLRPLDR 854 Query: 118 EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV--QDINDNTPNFASPVITL 175 E L +LE EV V P ++ V D+NDN+P F +P T+ Sbjct: 855 ELLGP----------VLELEVRAGSGVP---PAFAVARVRVLLDDVNDNSPAFPAPEDTV 901 Query: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235 +P NT G+ A D D+G N ++ L AG A + + +M Sbjct: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGG--------AFTVDPTTGHVRLM 953 Query: 236 GNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD--TNDNAPKFERPSYEAELSENS 293 L +++L ++ +DGGSPPR S LRV V D T AP+F P+Y +L + Sbjct: 954 RPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGT 1013 Query: 294 PIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRE--DLS 351 G V+QV+A D G T+H A E L+ +G + V+ +DRE +L Sbjct: 1014 TAGTQVLQVQAQAPDGG-----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELY 1068 Query: 352 TLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410 L+ ++ + ++ A V V++ + N+++P + + ++E+ Sbjct: 1069 ILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL--------SEDPTFLAVAENQPP 1120 Query: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSK------KKYFLQTTTPL 464 T+V V +DRD G N +T + L+Q SE DSK + + T L Sbjct: 1121 GTSVGRVFATDRDSGPNGRLT--------YSLQQLSE---DSKAFRIHPQTGEVTTLQTL 1169 Query: 465 DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV------TEVAFPEN 518 D E+ Y + + D G+PP S+T ++ V V+D+NDN+P F Q+ + P+ Sbjct: 1170 DREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDR 1229 Query: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578 PG ++ + A D D G N ++Y+L P ++ LF++ P +GE+ L R +R Y Sbjct: 1230 VPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSE-LFSLHPHSGELLTAAPLIRAERPHY 1287 Query: 579 ELKVVAADRGSPSLQGTATVLVNVL----------DCNDNDPKFMLS-GYNFSVMENMPA 627 L + A D+GSP + +LV VL D + DP + + E + Sbjct: 1288 VLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347 Query: 628 LSPVGMVTVID-GDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLK 686 S +G V + G + G F + +G + + D E + Sbjct: 1348 GSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTV 1407 Query: 687 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT-RLGETVSQVAAEDFD 745 +G + + V + V DEN++AP A + L P+ G + A D D Sbjct: 1408 RAEGPGGAGARLLRVQVQVQDENEHAP---AFARDPLALALPENPEPGAALYTFRASDAD 1464 Query: 746 S-GVNAELIYSIAGGN-PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797 G N+++ Y + P ++ + +GA++ + ++R L+V+ +DR Sbjct: 1465 GPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR 1518 Score = 187 bits (476), Expect = 3e-47 Identities = 175/649 (26%), Positives = 283/649 (43%), Gaps = 74/649 (11%) Query: 166 PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ-AGPEAQELFGLQVAED 224 P F ++PE+ G+ I A + P +A L +G + + LF L Sbjct: 788 PIFEQLQYVFSVPEDVAPGTSVGIVQAHNP---PGRLAPVTLSLSGGDPRGLFSLDAVSG 844 Query: 225 QEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-GSPPRASSALLRVTVLDTNDNAPKFERP 283 L + LDRE L ++V+ G G PP + A +RV + D NDN+P F P Sbjct: 845 L------LQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897 Query: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343 L N+ G + ++A D D G N+ + +T +D TG + + Sbjct: 898 EDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVDPTTGHVRLMR 954 Query: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND-------NAPTIEIRGIGLVT 396 P+ + A+D G+ P+++ ++ V V+D+ N+PT + Sbjct: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV------- 1007 Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456 ++ T V VQ D G PF L S Sbjct: 1008 ------DLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG--------- 1052 Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPL---SSTNSLKVQVVDVNDNAPVFTQSVTEV 513 +L LD E + Y ++++AV L + T +++V +++ N+++P ++ T + Sbjct: 1053 WLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFL 1112 Query: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE 573 A EN PG + + A+D DSG N L YSL+ F I P+TGE+ +LDRE Sbjct: 1113 AVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE 1172 Query: 574 QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS------GYNFSVMENMPA 627 Q+ SY+L V D GSP T TV V VLD NDN P F+ + G V + +P Sbjct: 1173 QQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPP 1232 Query: 628 LSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTYTFQLK 686 + V + D D+GEN + ++ + F + +G +L++ R ++ Y L Sbjct: 1233 GTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLS 1292 Query: 687 AVDGGVPPRSAYVGVTINVL-------------DENDNAPYITAPSNTSHKLLTPQTRLG 733 A D G PPRSA + + + VL + + AP + T+ + L P + LG Sbjct: 1293 AHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLG 1352 Query: 734 ETVSQVAAEDFDSGVNAELIYSIAGG-NPYGLFQIGSHSGAITLEKEIE 781 VAA + +GV A L Y++ GG +P G F + + SG + L + ++ Sbjct: 1353 ----SVAAPE-PAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLD 1395 Score = 144 bits (364), Expect = 3e-34 Identities = 147/573 (25%), Positives = 249/573 (43%), Gaps = 75/573 (13%) Query: 66 EEQPPNTLIGSLAA-DYGFPDVGHL-YKLEVGAPYLRVDGKTGDIFTTETSI----DREG 119 E PP + I S++A D GH+ Y L A VD G +FT ++ D G Sbjct: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG 2446 Query: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPE 179 ++ + D G +++QD ND+ P+F +A+ E Sbjct: 2447 A-------------VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493 Query: 180 NTNIGSLFPIPLASDRDAGPNGVA-SYELQAGPEAQELFGLQ--VAEDQEEKQPQ----- 231 + GS A+D D + A Y + +G + +F L+ +AE E P Sbjct: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPRLAEAGESAGPGPRALG 2552 Query: 232 -LIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290 L+++ LD E Y+LT+ D G PP++S + VTVLD NDN P F R SY + Sbjct: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612 Query: 291 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350 E++P+G ++ V+A+D+D G + + +T L LD ++G + + +D E Sbjct: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP--SGLFELDESSGTLRLAHALDCETQ 2670 Query: 351 STLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410 + + V A D A A V + V+D+ND+ P + + +++E+ Sbjct: 2671 ARHQLVVQAAD-PAGAHFALAPVTIEVQDVNDHGPAFPLNLLS--------TSVAENQPP 2721 Query: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTT-------P 463 T V + D D G G + + L +A G + ++ + L ++T P Sbjct: 2722 GTLVTTLHAIDGDAG--------AFGRLRYSLLEAG-PGPEGREAFALNSSTGELRARVP 2772 Query: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523 DYE + + + + A D+GN LS++ ++ V V ++ PVF PE + G Sbjct: 2773 FDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGH 2830 Query: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL------------- 570 + + A+D D G++ ++YSL + F I+ TG + ++ Sbjct: 2831 SLGHVQATDEDGGADGLVLYSL---ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGG 2887 Query: 571 DREQRES-YELKVVAADRGSPSLQGTATVLVNV 602 R +RE+ EL++ RG +ATV V V Sbjct: 2888 GRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920 Score = 117 bits (292), Expect = 7e-26 Identities = 99/345 (28%), Positives = 153/345 (44%), Gaps = 25/345 (7%) Query: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFT---ISPETGEIQVKT 568 ++ E G +I +I+A +G+ A L+Y + + + G+ T I +G ++ Sbjct: 48 DLQIDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGS-GVGTDLAIDEHSGVVRTAR 105 Query: 569 SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628 LDREQR+ Y V D T V V V D ND+ P F + V E+ Sbjct: 106 VLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEHTAFG 159 Query: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGT-----GTILSSL----SFDREQQS 679 + + D D G ++ D + T GT + L DRE +S Sbjct: 160 TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRS 219 Query: 680 TYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQV 739 Y QL+A DGG PPR A + + +LD ND+AP + H +++ G V QV Sbjct: 220 HYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFN--QSRYHAVVSESLAPGSPVLQV 277 Query: 740 AAEDFDSGVNAELIYSI--AGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797 A D D+GVN + Y I G F I +H+G + LE+ ++ +H LVV+ D Sbjct: 278 FASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDG 337 Query: 798 GKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDP 842 G P G+A V ++V + N+ + T++ S D + A P Sbjct: 338 GAHPELGSAFVTVHVRDANDNQPSM-TVIFLSADGSPQVSEAAPP 381 Score = 33.1 bits (74), Expect = 1.4 Identities = 52/216 (24%), Positives = 78/216 (36%), Gaps = 19/216 (8%) Query: 64 VPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLREC 123 V E QPP TL+ +L A G D G +L + + F +S E Sbjct: 2715 VAENQPPGTLVTTLHAIDG--DAGAFGRLRYSLLEAGPGPEGREAFALNSSTG-----EL 2767 Query: 124 QNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDI----NDNTPNFASPVITLAIPE 179 + ++P D E S LV L + V + ++ P F +P +PE Sbjct: 2768 RARVPFD---YEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPE 2824 Query: 180 NTNIGSLFPIPLASDRDAGPNGVASYELQAGPE----AQELFGLQVAEDQEEKQPQLIVM 235 G A+D D G +G+ Y L Q L + D Sbjct: 2825 GARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATS 2884 Query: 236 GNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTV 270 G R R ++ +L ++V G P + SA + VTV Sbjct: 2885 GGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920 >gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] Length = 4981 Score = 343 bits (881), Expect = 4e-94 Identities = 258/802 (32%), Positives = 391/802 (48%), Gaps = 58/802 (7%) Query: 41 SMLLALLLLLAPSPGHA------TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEV 94 S LL + LL+ PG A R V++V EEQPP TL+G++ GF Y+L Sbjct: 22 SQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPGFT-----YRLSE 76 Query: 95 GAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRL-LE 153 ++ TG ++TT T IDRE L P D L +V + +P E Sbjct: 77 SHALFAINSSTGALYTTST-IDRESL-------PSDVINL--------VVLSSAPTYPTE 120 Query: 154 GQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGV--ASYELQAGP 211 ++ V+D+NDN P F P I + E+++ G + A+D D G NGV SY + G Sbjct: 121 VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180 Query: 212 EAQEL-FGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTV 270 EA + + E L+ G LDRE Y L ++V+D G P R + VTV Sbjct: 181 EAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTV 240 Query: 271 LDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLL 330 D NDN P F Y+A + E++ +G SV+QV A D+D+G NA+I Y Sbjct: 241 QDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP----F 296 Query: 331 RLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIR 390 ++D TGLITV+ P+D E +V A DRG + RA+ ++ + D+NDN P ++ R Sbjct: 297 QMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFR 356 Query: 391 GIGLVTHQDGMANISEDVAEETAVALVQVSDRDE-GENAAVTCVVAGDVPFQLRQASETG 449 + A++ E+ T VAL+ V+D D N ++ + G + R Sbjct: 357 YFPATSR---YASVDENAQVGTVVALLTVTDADSPAANGNISVQILGG--NEQRHFEVQS 411 Query: 450 SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDS-GNPP------LSSTNSLKVQVVDVNDN 502 S ++ + LD E++ Y + + D+ G PP SS SL + V D+ND+ Sbjct: 412 SKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDH 471 Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562 PVF+Q V V E PG ++ I+A+D DSG NA L YS+ G F IS +G Sbjct: 472 PPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSI-VSGNGLGWFHISEHSG 530 Query: 563 EIQVKTS--LDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNF 619 + +S LDRE L + A D+G A ++V +LD ND P F GY+ Sbjct: 531 LVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDV 590 Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSFDRE 676 SV+EN P + + M+ DGD G+N V+ S+ E D F + +G + + S DRE Sbjct: 591 SVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE 650 Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736 +Q+ Y+ + A D G PP+S+ + +++LD NDN+P +H + G + Sbjct: 651 EQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAH--IKENEPGGSYI 708 Query: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796 + V+A D D G N + YSI+ G+ FQ+ + SG I+ ++R ++L + +D Sbjct: 709 TTVSATDPDLGTNGTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD 767 Query: 797 RGKPPRYGTALVHLYVNETLAN 818 G A+V + V +T N Sbjct: 768 GGNLQSPNQAIVTITVLDTQDN 789 Score = 290 bits (743), Expect = 4e-78 Identities = 229/764 (29%), Positives = 367/764 (48%), Gaps = 79/764 (10%) Query: 90 YKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSIT-DLVQNGS 148 Y+L+ ++D +TG + T +D E R+ S+T + G Sbjct: 287 YRLQDEGTPFQMDPETG-LITVREPLDFEARRQ---------------YSLTVQAMDRGV 330 Query: 149 PRLL---EGQIEVQDINDNTP-----NFASPVITLAIPENTNIGSLFPIPLASDRDA-GP 199 P L E I++ D+NDN P F + ++ EN +G++ + +D D+ Sbjct: 331 PSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAA 390 Query: 200 NGVASYELQAGPEAQELFGLQVAEDQEEKQPQLI---VMGNLDRERWDSYDLTIKVQDG- 255 NG S ++ G E + E Q K P L V LDRER SY+LT+ V D Sbjct: 391 NGNISVQILGGNEQRHF------EVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNY 444 Query: 256 GSPP------RASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQ 309 G+PP R+S A L + V D ND+ P F + Y LSE +P G V + A D D Sbjct: 445 GAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDS 504 Query: 310 GANAEIEYTFHQAPEVVRRLLRLDRNTGLITV--QGPVDREDLSTLRFSVLAKDRGTNPK 367 G NA + Y+ + + ++GL+T G +DRE S + ++ A+D+G +PK Sbjct: 505 GLNANLRYSIVSGNGL--GWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPK 562 Query: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGM-ANISEDVAEETAVALVQVSDRDEGE 426 + AQ+VVT+ D+ND P + +G ++ E+ T + +++ +D D G+ Sbjct: 563 VSYAQLVVTLLDVNDEKPVF--------SQPEGYDVSVVENAPTGTELLMLRATDGDLGD 614 Query: 427 NAAVTCVVAGDVPFQLRQASETGSDSKK----KYFLQTTTPLDYEKVKDYTIEIVAVDSG 482 N G V F L++A ET S + L T + LD E+ Y++ ++A D G Sbjct: 615 N--------GTVRFSLQEA-ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665 Query: 483 NPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELV 542 +PP SS + V ++D+NDN+PVF EN G I ++A+D D G+N + Sbjct: 666 SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVK 725 Query: 543 YSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNV 602 YS+ ++ F ++ ++G I + +LDRE++ +Y+L++VA D G+ A V + V Sbjct: 726 YSISAGDRSR--FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITV 783 Query: 603 LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQN 662 LD DN P F Y+F V EN+ VG V+ D N ++ G F I Sbjct: 784 LDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQ 843 Query: 663 GTGTILSSLSFDREQQSTYTFQLKAV-DGGVPPRSAYVGVTINVLDENDNAPYITAPSNT 721 TG + ++ DRE+QS Y QLK V GG V +T+ D NDN+P+ + Sbjct: 844 VTGQLTTANVIDREEQSFY--QLKVVASGGTVTGDTMVNITVK--DLNDNSPHFLQAIES 899 Query: 722 SHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781 + + + G ++ Q A D D GVN ++YS+ NP LF I +G I+L ++ Sbjct: 900 VN--VVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK-QNPKNLFAINEKNGTISLLGPLD 956 Query: 782 RRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETL 825 H G +++ + SD G P + ++ +YV++ N + + L Sbjct: 957 -VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL 999 Score = 290 bits (741), Expect = 6e-78 Identities = 224/688 (32%), Positives = 324/688 (47%), Gaps = 53/688 (7%) Query: 135 EFEVSITDLVQNGSPRLLEGQI---EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPL 191 + E+ +D+ G P+L I V D+NDN+P F + + E+ + S F Sbjct: 963 QIEILASDM---GVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQ 1019 Query: 192 ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIK 251 ASD+D+G NG +Y + G + FG+ QL + LDRE D Y L + Sbjct: 1020 ASDKDSGANGEIAYTIAEG-NTGDAFGIF-------PDGQLYIKSELDRELQDRYVLMVV 1071 Query: 252 VQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGA 311 D P +++ + V + D NDN P F +Y E G V +V A D D G Sbjct: 1072 ASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGP 1131 Query: 312 NAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLR------FSVLAKDRGT- 364 N E+ Y+F E+V+ L +G IT DRE L R F+V+A D+G Sbjct: 1132 NGEVRYSF----EMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIP 1187 Query: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDE 424 P +A V V +KD+NDNAP A ISE A T V V SD DE Sbjct: 1188 QPLKDQATVHVYMKDINDNAPKF--------LKDFYQATISESAANLTQVLRVSASDVDE 1239 Query: 425 GENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGN 483 G N + ++ G+ Q S +G + LDYE Y++ I AVDSG Sbjct: 1240 GNNGLIHYSIIKGNEERQFAIDSTSGQ-------VTLIGKLDYEATPAYSLVIQAVDSGT 1292 Query: 484 PPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVY 543 PL+ST +L + ++D NDN P F +S V EN + GE+++ +TA+D+DSG NA+L Y Sbjct: 1293 IPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYY 1352 Query: 544 SLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVL 603 S+ G F+ISP TG I + LD E + Y+L + A D+G P T +V+++V Sbjct: 1353 SI-TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVR 1411 Query: 604 DCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD---NGDFVI 660 D NDN P F S++EN+P + V VT D D N Q+ ++ Q F I Sbjct: 1412 DFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471 Query: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP---PRSAYVGVTINVLDENDNAPYITA 717 GTI ++ DRE + + +KA D VP R A VTI V D NDN P + Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531 Query: 718 PSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777 + + P +G ++ + A D D G N E+ Y I G+ F + +SG + + Sbjct: 1532 QNALA---ADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT-DTFIVDRYSGDLRVA 1587 Query: 778 KEIERRHHGLHRLVVKVSDRGKPPRYGT 805 + ++ L+V +D G R T Sbjct: 1588 SALVPSQL-IYNLIVSATDLGPERRKST 1614 Score = 284 bits (726), Expect = 4e-76 Identities = 222/762 (29%), Positives = 351/762 (46%), Gaps = 58/762 (7%) Query: 64 VPEEQPPNTLIGSLAADYGFPDVGH----LYKLEVG-APYLRVDGKTGDIFTTETSIDRE 118 + E +P + I +++A PD+G Y + G +V+ ++G + +T ++DRE Sbjct: 698 IKENEPGGSYITTVSATD--PDLGTNGTVKYSISAGDRSRFQVNAQSG-VISTRMALDRE 754 Query: 119 GLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIP 178 + + ++ TD SP I V D DN P F+ + + Sbjct: 755 -----------EKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVF 803 Query: 179 ENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNL 238 EN +G AS D N SY + G + + +F + + QL + Sbjct: 804 ENVALGYHVGSVSASTMDLNSN--ISYLITTGDQ-KGMFAIN------QVTGQLTTANVI 854 Query: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298 DRE Y L + V GG+ ++ +TV D NDN+P F + + EN GHS Sbjct: 855 DREEQSFYQLKV-VASGGTV--TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHS 911 Query: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVL 358 + Q KA D D+G N + Y+ Q P + L ++ G I++ GP+D + + +L Sbjct: 912 IFQAKAVDPDEGVNGMVLYSLKQNP---KNLFAINEKNGTISLLGPLDVH-AGSYQIEIL 967 Query: 359 AKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQ 418 A D G S+ + V V D+NDN+P + + +SE + VQ Sbjct: 968 ASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVT--------LSESEPVNSRFFKVQ 1019 Query: 419 VSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVA 478 SD+D G N + +A G L + LD E Y + +VA Sbjct: 1020 ASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQ-------LYIKSELDRELQDRYVLMVVA 1072 Query: 479 VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538 D PLS+T ++ V + DVNDN P+F + F E + G + +++A D D G N Sbjct: 1073 SDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPN 1132 Query: 539 AELVYSLEPEPAAKGLFTISPE---TGEIQVKTSLDREQRESYELKVVAADRGSPS-LQG 594 E+ YS E L IS E T + ++ + R + V+A D+G P L+ Sbjct: 1133 GEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKD 1192 Query: 595 TATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD 654 ATV V + D NDN PKF+ Y ++ E+ L+ V V+ D D+G N + S+ + Sbjct: 1193 QATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKG 1252 Query: 655 NGD--FVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNA 712 N + F I + +G + D E Y+ ++AVD G P ++ + I++LDENDN Sbjct: 1253 NEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNT 1312 Query: 713 PYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSG 772 P + P +T + R+GE VS V A D DSG NA+L YSI G N +G F I ++G Sbjct: 1313 P--SFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTG 1370 Query: 773 AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814 +I L K+++ L++L + D+G+PPR T V ++V + Sbjct: 1371 SIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412 Score = 276 bits (705), Expect = 1e-73 Identities = 213/674 (31%), Positives = 322/674 (47%), Gaps = 53/674 (7%) Query: 138 VSITDLVQNGSPRLL---EGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASD 194 V + DL Q + R + I + D+NDN P F SP +T IPENT I ++ A+D Sbjct: 2018 VQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATD 2076 Query: 195 RDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD 254 D+GPN Y L P + F + + + + G LDRE +Y LT+ D Sbjct: 2077 PDSGPNSYIEYTL-LNPLGNK-FSIGTIDGEVR------LTGELDREEVSNYTLTVVATD 2128 Query: 255 GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314 G P +SS + V VLD NDN P F + Y+ E++EN+ G +IQV A D D+G N + Sbjct: 2129 KGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQ 2188 Query: 315 IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374 + Y + R+D TG ITV P+DRE T +V A DRG+ P++ + V Sbjct: 2189 VRYGIVNGN--TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVS 2246 Query: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS-DRDEGENAAVTCV 433 + + D+ND P E+ + N+ E++ L V+ D D G N+ ++ V Sbjct: 2247 IVLLDINDFVPVFELSPYSV--------NVPENLGTLPRTILQVVARDDDRGSNSKLSYV 2298 Query: 434 VAG---DVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN 490 + G D F L + E G T LD E + + + I A DSG+P L+ T Sbjct: 2299 LFGGNEDNAFTLSASGELG----------VTQSLDRETKERFVLMITATDSGSPALTGTG 2348 Query: 491 SLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550 ++ V V DVNDN P F PE+ G + + ASDAD+ NA + Sbjct: 2349 TINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII-----G 2403 Query: 551 AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCNDND 609 FTI+P TG+I LDRE +++Y L VV +D GSP L + +VLV V D NDN Sbjct: 2404 GNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNP 2463 Query: 610 PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTIL 668 P+F Y + S V VTV D D G N+++ S+ N + F I G I+ Sbjct: 2464 PRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIM 2523 Query: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728 ++ + + T++ +K DGG P++ VT+ +++ D P + A T + P Sbjct: 2524 AAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQT---FMFP 2577 Query: 729 QTRLGETVSQVAAEDFDSGVNAE-LIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGL 787 + + VS + S + E + Y IA GN FQI +G +++ + ++ Sbjct: 2578 EN---QPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQK 2634 Query: 788 HRLVVKVSDRGKPP 801 + + ++ D G PP Sbjct: 2635 YVVWIEARDGGFPP 2648 Score = 274 bits (701), Expect = 3e-73 Identities = 216/706 (30%), Positives = 326/706 (46%), Gaps = 55/706 (7%) Query: 100 RVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159 R+D ++GD+ T +DRE + + D D +Q+ R+ I V Sbjct: 1788 RIDPESGDLIATRR-LDRERRSKYSLLVRAD-----------DGLQSSDMRI---NITVS 1832 Query: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGL 219 D+ND+TP F+ PV + IPE+T GSL LA+D D+G NG +Y + E F Sbjct: 1833 DVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLN 1892 Query: 220 QVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPK 279 + + LD E Y LT++ +DGG + ++ + +LD NDN P Sbjct: 1893 PITG-------VFNLTRLLDYEVQQYYILTVRAEDGGG--QFTTIRVYFNILDVNDNPPI 1943 Query: 280 FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLI 339 F SY L EN P+G +V+ D+D G N+++ Y+ + + +D+N G++ Sbjct: 1944 FSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ--FTVDKN-GVL 2000 Query: 340 TVQGPVDREDLSTLRFSVLAKDRGTNPKS---ARAQVVVTVKDMNDNAPTIEIRGIGLVT 396 V +DRE S V D P S + AQV + + D+NDN PT Sbjct: 2001 KVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFL-------- 2052 Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456 + I E+ +T V Q +D D G N+ + + + + + G Sbjct: 2053 -SPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGE------ 2105 Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516 ++ T LD E+V +YT+ +VA D G P LSS+ + V V+D+NDN P+F Q++ +V Sbjct: 2106 -VRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEIN 2164 Query: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576 EN G I ++ A+D D G+N ++ Y + F I TG I V LDRE+ Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGI-VNGNTNQEFRIDSVTGAITVAKPLDREKTP 2223 Query: 577 SYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL-SPVGMVT 635 +Y L V A DRGS T+TV + +LD ND P F LS Y+ +V EN+ L + V Sbjct: 2224 TYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVV 2283 Query: 636 VIDGDKGENAQVQLSVEQDNGDFVIQ-NGTGTILSSLSFDREQQSTYTFQLKAVDGGVPP 694 D D+G N+++ + N D + +G + + S DRE + + + A D G P Sbjct: 2284 ARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPA 2343 Query: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIY 754 + + + V D NDN P T S + G V V A D D+ NA + Sbjct: 2344 LTGTGTINVIVDDVNDNVP--TFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA--VI 2399 Query: 755 SIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800 I GGN F I +G I ++R + LVV SD G P Sbjct: 2400 RIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSP 2443 Score = 273 bits (698), Expect = 6e-73 Identities = 215/727 (29%), Positives = 338/727 (46%), Gaps = 56/727 (7%) Query: 149 PRLLEGQIEV--QDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206 PR ++E+ QDINDN P F + ++ L + EN GS A D D G N + +Y Sbjct: 1719 PRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYT 1778 Query: 207 LQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALL 266 + +G A + F + + + LI LDRER Y L ++ DG ++S + Sbjct: 1779 IISG--ADDSFRI------DPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRI 1827 Query: 267 RVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326 +TV D ND+ PKF RP Y ++ E++ G V + A D D G N EI Y ++ E Sbjct: 1828 NITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDE-- 1885 Query: 327 RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386 + L+ TG+ + +D E +V A+D G + R V + D+NDN P Sbjct: 1886 DGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIR--VYFNILDVNDNPPI 1943 Query: 387 IEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQAS 446 + ++ E++ + V + V+D D+G N+ +T +A Sbjct: 1944 FSLNSYS--------TSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD 1995 Query: 447 ETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLS---STNSLKVQVVDVNDNA 503 + G L+ LD E Y + + D P S ST + + ++DVNDN Sbjct: 1996 KNG-------VLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNP 2048 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 P F S PEN V+ + A+D DSG N+ + Y+L K F+I GE Sbjct: 2049 PTFL-SPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK--FSIGTIDGE 2105 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 +++ LDRE+ +Y L VVA D+G PSL + V+V VLD NDN+P F + Y + E Sbjct: 2106 VRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINE 2165 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG--DFVIQNGTGTILSSLSFDREQQSTY 681 N + + V DGD+G N QV+ + N +F I + TG I + DRE+ TY Sbjct: 2166 NTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTY 2225 Query: 682 TFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT--RLGETVSQV 739 ++A D G PR+ V+I +LD ND P + + + P+ L T+ QV Sbjct: 2226 HLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFEL---SPYSVNVPENLGTLPRTILQV 2282 Query: 740 AAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGK 799 A D D G N++L Y + GGN F + S SG + + + ++R L++ +D G Sbjct: 2283 VARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGS 2341 Query: 800 PPRYGTALVHLYVNE------TLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNI 853 P GT +++ V++ T A++ T + T D+ + + + SK N Sbjct: 2342 PALTGTGTINVIVDDVNDNVPTFASKAYF-TTIPEDAPTGTDVLLVNASDADASK---NA 2397 Query: 854 LFGVVAG 860 + ++ G Sbjct: 2398 VIRIIGG 2404 Score = 260 bits (665), Expect = 4e-69 Identities = 197/663 (29%), Positives = 309/663 (46%), Gaps = 31/663 (4%) Query: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215 I V D+NDN P F I EN + + + A D+D+GPNG YE+ G + Sbjct: 2657 ITVLDVNDNAPIFKEDPFISEILENLSPRKILTVS-AMDKDSGPNGQLDYEIVNG-NMEN 2714 Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275 F + A + + LDRE+ Y LTIK D GSP +++S + + +LD ND Sbjct: 2715 SFSINHATGEIRS------VRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDEND 2768 Query: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335 NAP+F + + A + ENSP+G++V +V +D D G NA Y+ A ++ + Sbjct: 2769 NAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDA----SLPFTINPS 2823 Query: 336 TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395 TG I + P++RED R V A D G + V + V D+NDNAP L Sbjct: 2824 TGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDINDNAPRFSRTSYYL- 2879 Query: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKK 455 + E + V V +D DEG N V + + A+ +K+ Sbjct: 2880 -------DCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQI 2932 Query: 456 YFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAF 515 Q T + ++ + + D G P L S ++ + +VD NDNAP F +S Sbjct: 2933 LKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPV 2992 Query: 516 PENNKPGEVIAEITA-SDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQ 574 +N K G + +TA D D G N+E+ Y + + G F + +TG I V +SL + Sbjct: 2993 TKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHL-GKFKLDNDTGWISVASSLISDL 3051 Query: 575 RESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMV 634 +++ + V A D+G+P L ATV + V + N + P+F S + ++ E+ S V V Sbjct: 3052 NQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV 3111 Query: 635 TVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGV 692 + D D N ++ S+ N G F I + TG + + + D E + + A+DGG Sbjct: 3112 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGW 3171 Query: 693 PPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAEL 752 R+ Y VT+NV+D NDN+P S+ + G TV + A D DSG NA + Sbjct: 3172 VARTGYCSVTVNVIDVNDNSPVFL--SDDYFPTVLENAPSGTTVIHLNATDADSGTNAVI 3229 Query: 753 IYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812 Y++ + LF I ++G IT + ++ + L VK + R A V++ + Sbjct: 3230 AYTVQSSDS-DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQL 3288 Query: 813 NET 815 T Sbjct: 3289 KGT 3291 Score = 260 bits (664), Expect = 5e-69 Identities = 212/669 (31%), Positives = 298/669 (44%), Gaps = 47/669 (7%) Query: 138 VSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDA 197 V TD Q E + V DINDN P FA + + I ENT G+ A+D D Sbjct: 2124 VVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDE 2183 Query: 198 GPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS 257 G NG Y + G QE + + V LDRE+ +Y LT++ D GS Sbjct: 2184 GTNGQVRYGIVNGNTNQEF-------RIDSVTGAITVAKPLDREKTPTYHLTVQATDRGS 2236 Query: 258 PPRASSALLRVTVLDTNDNAPKFERPSYEAELSEN-SPIGHSVIQVKANDSDQGANAEIE 316 PR ++ + + +LD ND P FE Y + EN + +++QV A D D+G+N+++ Sbjct: 2237 TPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLS 2296 Query: 317 YTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376 Y E L +G + V +DRE + A D G+ + + V Sbjct: 2297 YVLFGGNEDNAFTLSA---SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVI 2353 Query: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436 V D+NDN PT + I ED T V LV SD D +NA + ++ G Sbjct: 2354 VDDVNDNVPTFASKAY--------FTTIPEDAPTGTDVLLVNASDADASKNAVIR-IIGG 2404 Query: 437 DVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQ 495 + F + + TG + T+ LD E +YT+ +V D+G+P PLSS+ S+ V Sbjct: 2405 NSQFTINPS--TGQ-------IITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVT 2455 Query: 496 VVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLF 555 V DVNDN P F P PG + +T +DAD G N+EL YSL + K F Sbjct: 2456 VTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEK--F 2513 Query: 556 TISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS 615 I P G I L+ ++ + V D GS + TV V ++ D PK Sbjct: 2514 HIDPLRGAIMAAGPLNGASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKAD-FPKVRAK 2570 Query: 616 GYNFSVMENMPALSPVGMVTVIDGD--KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSF 673 F EN P S +VT I G +GE ++ F I TG + S Sbjct: 2571 EQTFMFPENQPVSS---LVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPL 2627 Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKL--LTPQTR 731 D E+ Y ++A DGG PP S+Y + I VLD NDNAP S L L+P+ Sbjct: 2628 DFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPR-- 2685 Query: 732 LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791 + V+A D DSG N +L Y I GN F I +G I + ++R + L Sbjct: 2686 ---KILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLT 2742 Query: 792 VKVSDRGKP 800 +K SD+G P Sbjct: 2743 IKSSDKGSP 2751 Score = 259 bits (662), Expect = 9e-69 Identities = 237/745 (31%), Positives = 342/745 (45%), Gaps = 73/745 (9%) Query: 70 PNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPG 129 P T++ +A D D G KL Y+ G + FT S + G+ + ++ Sbjct: 2276 PRTILQVVARD---DDRGSNSKLS----YVLFGGNEDNAFTLSASGEL-GVTQSLDRETK 2327 Query: 130 DPCILEFEVSITDLVQNGSPRLL-EGQIEV--QDINDNTPNFASPVITLAIPENTNIGSL 186 + +L ++ TD +GSP L G I V D+NDN P FAS IPE+ G+ Sbjct: 2328 ERFVLM--ITATD---SGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTD 2382 Query: 187 FPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSY 246 + ASD DA N V + G Q+I LDRE D+Y Sbjct: 2383 VLLVNASDADASKNAVI-----------RIIGGNSQFTINPSTGQIITSALLDRETKDNY 2431 Query: 247 DLTIKVQDGGSP-PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKAN 305 L + D GSP P +SS + VTV D NDN P+F+ Y + + G V V Sbjct: 2432 TLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVT 2491 Query: 306 DSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTN 365 D+D G N+E+ Y+ +D G I GP++ S + FSV KD G+ Sbjct: 2492 DADIGPNSELHYSLSGRNS---EKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSF 2546 Query: 366 PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEG 425 PK+ V V + D P + + Q M ++ V+ + S R E Sbjct: 2547 PKTDSTTVTVRFVNKAD-FPKVRAK------EQTFMFPENQPVSS-LVTTITGSSLRGEP 2598 Query: 426 ENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPP 485 + + G+ FQ+ Q + S S+ PLD+EK++ Y + I A D G PP Sbjct: 2599 MSYYIASGNLGNT-FQIDQLTGQVSISQ---------PLDFEKIQKYVVWIEARDGGFPP 2648 Query: 486 LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545 SS L + V+DVNDNAP+F + EN P +++ ++A D DSG N +L Y + Sbjct: 2649 FSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILT-VSAMDKDSGPNGQLDYEI 2707 Query: 546 EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605 + F+I+ TGEI+ LDRE+ Y L + ++D+GSPS + V++N+LD Sbjct: 2708 -VNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDE 2766 Query: 606 NDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTG 665 NDN P+F ++ V EN P V VT D D G NA + S+ + F I TG Sbjct: 2767 NDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTG 2825 Query: 666 TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKL 725 I+ S +RE Y ++ A D G + VTI V D NDNAP S TS+ L Sbjct: 2826 DIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRF---SRTSYYL 2879 Query: 726 LTPQ-TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRH 784 P+ T +G V+QV A D D G N ++ Y I + Y F+I + +G I K+I + Sbjct: 2880 DCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEY--FRINATTGEI-FNKQILKYQ 2936 Query: 785 H---------GLHRLVVKVSDRGKP 800 + H +V SDRGKP Sbjct: 2937 NVTGFSNVNINRHSFIVTSSDRGKP 2961 Score = 238 bits (607), Expect = 2e-62 Identities = 198/680 (29%), Positives = 301/680 (44%), Gaps = 53/680 (7%) Query: 140 ITDLVQNGSPR---LLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196 + ++ G P+ L+ + VQDINDN P F S +PE+ +GS A+D D Sbjct: 219 LVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADAD 278 Query: 197 AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 256 G N Y LQ ++ + + + V LD E Y LT++ D G Sbjct: 279 EGTNADIRYRLQDEGTPFQM---------DPETGLITVREPLDFEARRQYSLTVQAMDRG 329 Query: 257 SPPRASSALLRVTVLDTNDNAPK-----FERPSYEAELSENSPIGHSVIQVKANDSDQ-G 310 P A + +LD NDN P F S A + EN+ +G V + D+D Sbjct: 330 VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPA 389 Query: 311 ANAEIEYTFHQAPEVVRRLLRLDR--NTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-- 366 AN I E ++ + N LI V +DRE + + +V D P Sbjct: 390 ANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPG 449 Query: 367 -----KSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSD 421 +S+ A +V+ V D+ND+ P + Q N+SE+ + V+ + +D Sbjct: 450 AAVQARSSVASLVIFVNDINDHPPVF--------SQQVYRVNLSEEAPPGSYVSGISATD 501 Query: 422 RDEGENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTTP---LDYEKVKDYTIEIV 477 D G NA + +V+G+ + +G L TT LD E + I Sbjct: 502 GDSGLNANLRYSIVSGNGLGWFHISEHSG--------LVTTGSSGGLDRELASQIVLNIS 553 Query: 478 AVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT-EVAFPENNKPGEVIAEITASDADSG 536 A D G P S L V ++DVND PVF+Q +V+ EN G + + A+D D G Sbjct: 554 ARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLG 613 Query: 537 SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596 N + +SL+ + F + P +G + +SLDRE++ Y L V+A D GSP A Sbjct: 614 DNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMA 673 Query: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQ-DN 655 + V++LD NDN P F Y + EN P S + V+ D D G N V+ S+ D Sbjct: 674 RINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR 733 Query: 656 GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYI 715 F + +G I + ++ DRE+++ Y Q+ A DGG VTI VLD DN P Sbjct: 734 SRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVF 793 Query: 716 TAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAIT 775 + + + ++ LG V V+A D +N+ + Y I G+ G+F I +G +T Sbjct: 794 SQVAYSF--VVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLT 849 Query: 776 LEKEIERRHHGLHRLVVKVS 795 I+R ++L V S Sbjct: 850 TANVIDREEQSFYQLKVVAS 869 Score = 236 bits (601), Expect = 1e-61 Identities = 201/691 (29%), Positives = 313/691 (45%), Gaps = 46/691 (6%) Query: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE--- 212 I V DINDN P F+ L PE T IGS A+D D G NG Y +++ E Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFR 2919 Query: 213 ----AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268 E+F Q+ + Q + N++ R + + D G P S + + Sbjct: 2920 INATTGEIFNKQILKYQN-----VTGFSNVNINR---HSFIVTSSDRGKPSLISETTVTI 2971 Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA-NDSDQGANAEIEYTFHQAPEVVR 327 ++D+NDNAP+F + Y +++N +G +I+V A +D D G N+E+EY + + Sbjct: 2972 NIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031 Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387 +LD +TG I+V + + +V AKD+G P S++A V +TV + N + P Sbjct: 3032 --FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEF 3089 Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447 +H A I E + + V V DRD N G + + + +E Sbjct: 3090 S------QSHMS--ATIPESHSIGSIVRTVSARDRDAAMN--------GLIKYSISSGNE 3133 Query: 448 TG--SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505 G + + L LDYE + + + I A+D G + S+ V V+DVNDN+PV Sbjct: 3134 EGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPV 3193 Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ 565 F EN G + + A+DADSG+NA + Y+++ + LF I P TG I Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS--DLFVIDPNTGVIT 3251 Query: 566 VKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENM 625 + LD E ++SY L V A + ATV + + N+ P+F+ Y F + E Sbjct: 3252 TQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAA 3311 Query: 626 PALSPVGMVTVIDGDKGENAQVQLSV--EQDNGDFVIQNGTGTILSSLSFDREQQSTYTF 683 P + VG V D D G + +V + F I TG I S DRE++ + Sbjct: 3312 PKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSL 3371 Query: 684 QLKAVDGGVPPRSAYVGVTINV--LDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAA 741 ++ A + G + VT+NV LD ND P T N ++ +G V+ V+A Sbjct: 3372 KVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTL--NIYSVQISEGVPIGTHVTFVSA 3428 Query: 742 EDFDSGVN-AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800 D DS + + Y I GN G F I +G IT+ E++R ++ L V D G P Sbjct: 3429 FDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTP 3488 Query: 801 PRYGTALVHLYVNETLANRTLLETLLGHSLD 831 G+A + + + + N +L G ++ Sbjct: 3489 SATGSASLLVTLEDINDNGPMLTVSEGEVME 3519 Score = 233 bits (593), Expect = 9e-61 Identities = 182/675 (26%), Positives = 306/675 (45%), Gaps = 54/675 (8%) Query: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215 I + D NDN P F S + + +PEN+ +G SD D G N ++ Y + +A Sbjct: 2761 INILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM---DASL 2816 Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275 F + + +++ L+RE D Y + + D G S + + V D ND Sbjct: 2817 PFTINPSTGD------IVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDIND 2867 Query: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVR-------- 327 NAP+F R SY + E + IG V QV A D D+G+N ++ Y E R Sbjct: 2868 NAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEI 2927 Query: 328 ---RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNA 384 ++L+ TG V +++ F V + DRG + V + + D NDNA Sbjct: 2928 FNKQILKYQNVTGFSNV-------NINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2980 Query: 385 PTIEIRGIGLVTHQDGMANISEDVAEETA-VALVQVSDRDEGENAAVTCVVAGDVPF-QL 442 P ++++V T + + + D+D G N+ V ++ D + Sbjct: 2981 PQF--------LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKF 3032 Query: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502 + ++TG ++ + L + +++ I + A D GNPPLSS ++ + V + N + Sbjct: 3033 KLDNDTG-------WISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYH 3085 Query: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562 P F+QS PE++ G ++ ++A D D+ N + YS+ +G+F I+ TG Sbjct: 3086 TPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS-SGNEEGIFAINSSTG 3144 Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVM 622 + + +LD E + +E+ + A D G + G +V VNV+D NDN P F+ Y +V+ Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204 Query: 623 ENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTY 681 EN P+ + V + D D G NA + +V+ + D FVI TG I + D E + +Y Sbjct: 3205 ENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSY 3264 Query: 682 TFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAA 741 +KA + R ++ V I + N+ P S + ++ G V +V A Sbjct: 3265 HLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFV--SKLYYFEISEAAPKGTIVGEVFA 3322 Query: 742 EDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPP 801 D D G + E+ Y I G + FQI +G I + ++R R+ +KV + Sbjct: 3323 SDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKE--ERVSLKVLAKNFGS 3380 Query: 802 RYGTALVHLYVNETL 816 G + + VN T+ Sbjct: 3381 IRGADIDEVTVNVTV 3395 Score = 224 bits (570), Expect = 4e-58 Identities = 219/771 (28%), Positives = 334/771 (43%), Gaps = 92/771 (11%) Query: 70 PNTLIGS-----LAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQ 124 P+ +IGS +AAD PD G ++E Y ++G T S D LR Sbjct: 1539 PSAVIGSVLTTIMAAD---PDEGANGEIE----YEIINGDTDTFIVDRYSGD---LRVAS 1588 Query: 125 NQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184 +P I VS TDL E I +Q ++ P F P + E IG Sbjct: 1589 ALVPSQ-LIYNLIVSATDLGPERRKSTTELTIILQGLDG--PVFTQPKYITILKEGEPIG 1645 Query: 185 S-LFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGN------ 237 + + I AS R G EA + + +E+ +L +G Sbjct: 1646 TNVISIEAASPR--------------GSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQ 1691 Query: 238 ----LDRERWDSYDLT--IKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSE 291 LDRE+ L ++ + PR A + +T+ D NDN P F + + E Sbjct: 1692 TAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEE 1751 Query: 292 NSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLS 351 N G ++Q+ A D+D+GANA + YT + R+D +G + +DRE S Sbjct: 1752 NIGDGSKIMQLTAMDADEGANALVTYTIISGAD---DSFRIDPESGDLIATRRLDRERRS 1808 Query: 352 TLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEE 411 V A D +S+ ++ +TV D+ND+ P +I ED Sbjct: 1809 KYSLLVRADD---GLQSSDMRINITVSDVNDHTPKFSRPVYSF--------DIPEDTIPG 1857 Query: 412 TAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP-------L 464 + VA + +D D G N +T +V D D +FL T L Sbjct: 1858 SLVAAILATDDDSGVNGEITYIVNED-------------DEDGIFFLNPITGVFNLTRLL 1904 Query: 465 DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEV 524 DYE + Y + + A D G +T + ++DVNDN P+F+ + + EN G Sbjct: 1905 DYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGST 1962 Query: 525 IAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584 + +DAD G N++L YS+ + G FT+ + G ++V +LDRE + Y L V Sbjct: 1963 VLVFNVTDADDGINSQLTYSIASGDSL-GQFTVD-KNGVLKVLKALDRESQSFYNLVVQV 2020 Query: 585 ADRGS-PSLQGTATVLVNV--LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDK 641 D P+ + T+T V++ LD NDN P F+ + + EN P + V D D Sbjct: 2021 HDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDS 2079 Query: 642 GENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG 700 G N+ ++ ++ G+ F I G + + DRE+ S YT + A D G P S+ Sbjct: 2080 GPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTE 2139 Query: 701 VTINVLDENDNAPYITAPSNTSHKL-LTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759 V + VLD NDN P + +K+ + T G + QV A D D G N ++ Y I G Sbjct: 2140 VVVMVLDINDNNPIF---AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNG 2196 Query: 760 NPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHL 810 N F+I S +GAIT+ K ++R + L V+ +DRG PR T+ V + Sbjct: 2197 NTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247 Score = 213 bits (542), Expect = 8e-55 Identities = 192/745 (25%), Positives = 306/745 (41%), Gaps = 55/745 (7%) Query: 84 PDVGH----LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVS 139 PD G Y ++ + Y R++ TG+IF + + + QN + Sbjct: 2899 PDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQ-------ILKYQNVTGFSNVNINRHSF 2951 Query: 140 ITDLVQNGSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGS-LFPIPLASDR 195 I G P L+ I + D NDN P F + +N +G+ L + D+ Sbjct: 2952 IVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDK 3011 Query: 196 DAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDG 255 D G N Y + L ++ D + V +L + ++ +T+ +D Sbjct: 3012 DFGLNSEVEYFIS---NDNHLGKFKLDNDTG----WISVASSLISDLNQNFFITVTAKDK 3064 Query: 256 GSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEI 315 G+PP +S A + +TV + N + P+F + A + E+ IG V V A D D N I Sbjct: 3065 GNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLI 3124 Query: 316 EYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVV 375 +Y+ E + ++ +TG++T+ +D E ++ A D G ++ V V Sbjct: 3125 KYSISSGNE--EGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTV 3182 Query: 376 TVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVA 435 V D+NDN+P D + E+ T V + +D D G NA + V Sbjct: 3183 NVIDVNDNSPVF--------LSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQ 3234 Query: 436 GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQ 495 TG + T LD+E + Y + + A + + S ++ +Q Sbjct: 3235 SSDSDLFVIDPNTG-------VITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQ 3287 Query: 496 VVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLF 555 + N+ P F + E G ++ E+ ASD D G++ E+ Y + KG F Sbjct: 3288 LKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG-F 3346 Query: 556 TISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGT----ATVLVNVLDCNDNDPK 611 I+ +TG+I V LDRE+ E LKV+A + GS ++G TV V VLD ND P Sbjct: 3347 QINKKTGQIYVSGILDREKEERVSLKVLAKNFGS--IRGADIDEVTVNVTVLDAND-PPI 3403 Query: 612 FMLSGYNFSVMENMPALSPVGMVTVIDGDK---GENAQVQLSVEQDNGDFVIQNGTGTIL 668 F L+ Y+ + E +P + V V+ D D + +NG F I TG I Sbjct: 3404 FTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQIT 3463 Query: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728 + DRE Y + AVD G P + + + + D NDN P +T S + Sbjct: 3464 VTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLT----VSEGEVME 3519 Query: 729 QTRLGETVSQVAAEDFDSGVN-AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGL 787 R G V + + D D N Y + P + S +G ++ +EI+R Sbjct: 3520 NKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIAD 3579 Query: 788 HRLVVKVSDRGKPPRYGTALVHLYV 812 L V D G P T VH+ V Sbjct: 3580 FYLSVVTKDSGVPQMSSTGTVHITV 3604 Score = 209 bits (532), Expect = 1e-53 Identities = 173/565 (30%), Positives = 270/565 (47%), Gaps = 40/565 (7%) Query: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215 I V + N +TP F+ ++ IPE+ +IGS+ A DRDA NG+ Y + +G E + Sbjct: 3077 ITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNE-EG 3135 Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275 +F + + L + LD E +++TI DGG R + V V+D ND Sbjct: 3136 IFAINSSTGI------LTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVND 3189 Query: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335 N+P F Y + EN+P G +VI + A D+D G NA I YT + L +D N Sbjct: 3190 NSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS---DLFVIDPN 3246 Query: 336 TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395 TG+IT QG +D E + +V A + + + A V + +K N+ P R + + Sbjct: 3247 TGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVP----RFVSKL 3302 Query: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVP---FQLRQASETGSDS 452 + + ISE + T V V SDRD G + V ++ G+ FQ+ + Sbjct: 3303 YYFE----ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI---------N 3349 Query: 453 KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN--SLKVQVVDVNDNAPVFTQSV 510 KK + + LD EK + +++++A + G+ + + ++ V V+D ND P+FT ++ Sbjct: 3350 KKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNI 3408 Query: 511 TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570 V E G + ++A D+DS + G F+I+P+TG+I V L Sbjct: 3409 YSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAEL 3468 Query: 571 DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630 DRE Y L V+A D G+PS G+A++LV + D NDN P ML+ VMEN + Sbjct: 3469 DRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP--MLTVSEGEVMENKRPGTL 3526 Query: 631 VGMVTVIDGD----KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLK 686 V + D D +G LS F + G + ++ DREQ + + + Sbjct: 3527 VMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVV 3585 Query: 687 AVDGGVPPRSAYVGVTINVLDENDN 711 D GVP S+ V I V+D+NDN Sbjct: 3586 TKDSGVPQMSSTGTVHITVIDQNDN 3610 >gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor [Homo sapiens] Length = 1007 Score = 342 bits (878), Expect = 8e-94 Identities = 240/693 (34%), Positives = 359/693 (51%), Gaps = 56/693 (8%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFP----DVGHLYKL 92 LLLP LL LLLLL P P A+++ Y VPEEQ P L+G++A G G L Sbjct: 24 LLLP--LLLLLLLLLPGPA-ASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRIN 80 Query: 93 EVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSP 149 +GAP YL +D +G +F E IDRE L E + + C+L EV + V + Sbjct: 81 HLGAPSPRYLELDLTSGALFVNER-IDREALCEQRPR-----CLLSLEVLAHNPVAVSAV 134 Query: 150 RLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA 209 ++E+ DINDN+P F P L + E+ G+ F I A D D G N V +YEL Sbjct: 135 -----EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSP 189 Query: 210 GPEAQELFGLQVAEDQEE-KQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268 E F L + QE K +L++ LDRE+ + L + DGG P R+ +A + V Sbjct: 190 S----EHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISV 245 Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVR 327 VLDTNDN+P F++ +Y +L E+SP G V+++ A+D D+G+N E+ Y+ + R Sbjct: 246 RVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRER 305 Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387 +L +D +TG + V G +D E+ S+ + V A DRG P + +V+V + D+NDNAP + Sbjct: 306 QLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEV 365 Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447 + D + + E+ T VA++ V+D+D G N V+ + +PF+L Sbjct: 366 VL--------TDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGN 417 Query: 448 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507 + Y L + PLD E+V Y I + A D G P L+S +LKV++ D+NDN P F Sbjct: 418 S-------YTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL 470 Query: 508 QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL-----FTISPETG 562 + + ENN PG ++ + A+D D NAE+ YSL E +GL +I+ +G Sbjct: 471 EDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSL-LEREIQGLPVTSYVSINSASG 529 Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM--LSGYNFS 620 + S D E+ + + V A D+GSP L T T V V+D ND+ P + S + + Sbjct: 530 SLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSA 589 Query: 621 VMENMPALSPVG----MVTVIDGDKGENAQV--QLSVEQDNGDFVIQNGTGTILSSLSFD 674 E +P +P G V +D D G+NA + L+ D F ++ TG I ++ Sbjct: 590 AFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMG 649 Query: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707 E ST+ + D G P SA V +T+ V+D Sbjct: 650 DESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682 Score = 224 bits (570), Expect = 4e-58 Identities = 172/563 (30%), Positives = 264/563 (46%), Gaps = 43/563 (7%) Query: 259 PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYT 318 P A SA+ V +LD NDN+P+F RP+Y+ ++SE+ G A D D GAN+ Y Sbjct: 128 PVAVSAV-EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYE 186 Query: 319 FHQAPEVVRRLLRLDRNTGLI--TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376 + L L N+ ++ ++ +DRE + + A D G +S AQ+ V Sbjct: 187 LSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVR 246 Query: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436 V D NDN+P + + ED T V + SD DEG N G Sbjct: 247 VLDTNDNSPAFD--------QSTYRVQLREDSPPGTLVVKLNASDPDEGSN--------G 290 Query: 437 DVPFQLRQASETGSDSKKKYFLQTTTP-------LDYEKVKDYTIEIVAVDSGNPPLSST 489 ++ + L +S T ++ + + +T LDYE+ Y I + A D G P++ Sbjct: 291 ELRYSL--SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348 Query: 490 NSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE- 548 + V +VDVNDNAP + PEN P ++A ++ +D DSG N ++ LE Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408 Query: 549 PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDN 608 P F S + V LDRE+ Y + V A D G P L T+ V + D NDN Sbjct: 409 PFRLNGFGNSYT---LVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDN 465 Query: 609 DPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQ 661 P F+ Y+ + EN + V D D+ ENA+V S+ + + I Sbjct: 466 PPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSIN 525 Query: 662 NGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNT 721 + +G++ + SFD E+ + ++A D G PP S+ V + V+D ND+AP+I P++T Sbjct: 526 SASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585 Query: 722 SHKL---LTPQTR-LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777 + + P+T G V++V A D DSG NA L Y +A + LF++ H+G I Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTT 645 Query: 778 KEIERRHHGLHRLVVKVSDRGKP 800 +++ L V V D G+P Sbjct: 646 RKMGDESGSTFNLTVVVRDNGEP 668 Score = 200 bits (508), Expect = 7e-51 Identities = 158/502 (31%), Positives = 235/502 (46%), Gaps = 37/502 (7%) Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLR------FSVLAKDRGTNPKSARAQVVVTVKDMN 381 R L LD +G + V +DRE L R VLA NP + A V V + D+N Sbjct: 88 RYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAH----NPVAVSA-VEVEILDIN 142 Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441 DN+P L +SE VA + D D G N+ T ++ F+ Sbjct: 143 DNSPRFPRPNYQL--------QVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFE 194 Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501 L + ++ K L LD E+ + + + AVD G P S T + V+V+D ND Sbjct: 195 LDL--KPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTND 252 Query: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA--AKGLFTISP 559 N+P F QS V E++ PG ++ ++ ASD D GSN EL YSL + + LF+I Sbjct: 253 NSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDA 312 Query: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619 TGE++V LD E+ SY++ V A DRG + G VLV+++D NDN P+ +L+ Sbjct: 313 STGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYS 372 Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTG---TILSSLSFDRE 676 V EN + V +++V D D G N +V L +E + NG G T++ S DRE Sbjct: 373 PVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRL--NGFGNSYTLVVSGPLDRE 430 Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GET 735 + + Y + A DGG+P ++ + + + D NDN P S+ + + L G Sbjct: 431 RVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL---EDSYSIYIQENNLPGVL 487 Query: 736 VSQVAAEDFDSGVNAELIYSIAGGNPYGL-----FQIGSHSGAITLEKEIERRHHGLHRL 790 + V A D D NAE+ YS+ GL I S SG++ + + Sbjct: 488 LCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFV 547 Query: 791 VVKVSDRGKPPRYGTALVHLYV 812 V+ D+G PP T ++YV Sbjct: 548 TVEAQDKGSPPLSSTVTANVYV 569 Score = 48.1 bits (113), Expect = 4e-05 Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 18/132 (13%) Query: 697 AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA------AEDFDSGVNA 750 A V + +LD NDN+P P+ Q ++ E+V+ A A+D D G N+ Sbjct: 130 AVSAVEVEILDINDNSPRFPRPNY--------QLQVSESVAPGARFHIESAQDPDVGANS 181 Query: 751 ELIYSIAGGNPYGL----FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTA 806 Y ++ + L Q S + L K ++R LH LV+ D G P R GTA Sbjct: 182 VQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTA 241 Query: 807 LVHLYVNETLAN 818 + + V +T N Sbjct: 242 QISVRVLDTNDN 253 >gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor [Homo sapiens] Length = 884 Score = 342 bits (878), Expect = 8e-94 Identities = 240/693 (34%), Positives = 359/693 (51%), Gaps = 56/693 (8%) Query: 37 LLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFP----DVGHLYKL 92 LLLP LL LLLLL P P A+++ Y VPEEQ P L+G++A G G L Sbjct: 24 LLLP--LLLLLLLLLPGPA-ASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRIN 80 Query: 93 EVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSP 149 +GAP YL +D +G +F E IDRE L E + + C+L EV + V + Sbjct: 81 HLGAPSPRYLELDLTSGALFVNER-IDREALCEQRPR-----CLLSLEVLAHNPVAVSAV 134 Query: 150 RLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA 209 ++E+ DINDN+P F P L + E+ G+ F I A D D G N V +YEL Sbjct: 135 -----EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSP 189 Query: 210 GPEAQELFGLQVAEDQEE-KQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268 E F L + QE K +L++ LDRE+ + L + DGG P R+ +A + V Sbjct: 190 S----EHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISV 245 Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVR 327 VLDTNDN+P F++ +Y +L E+SP G V+++ A+D D+G+N E+ Y+ + R Sbjct: 246 RVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRER 305 Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387 +L +D +TG + V G +D E+ S+ + V A DRG P + +V+V + D+NDNAP + Sbjct: 306 QLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEV 365 Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447 + D + + E+ T VA++ V+D+D G N V+ + +PF+L Sbjct: 366 VL--------TDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGN 417 Query: 448 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507 + Y L + PLD E+V Y I + A D G P L+S +LKV++ D+NDN P F Sbjct: 418 S-------YTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL 470 Query: 508 QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL-----FTISPETG 562 + + ENN PG ++ + A+D D NAE+ YSL E +GL +I+ +G Sbjct: 471 EDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSL-LEREIQGLPVTSYVSINSASG 529 Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM--LSGYNFS 620 + S D E+ + + V A D+GSP L T T V V+D ND+ P + S + + Sbjct: 530 SLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSA 589 Query: 621 VMENMPALSPVG----MVTVIDGDKGENAQV--QLSVEQDNGDFVIQNGTGTILSSLSFD 674 E +P +P G V +D D G+NA + L+ D F ++ TG I ++ Sbjct: 590 AFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMG 649 Query: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707 E ST+ + D G P SA V +T+ V+D Sbjct: 650 DESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682 Score = 224 bits (570), Expect = 4e-58 Identities = 172/563 (30%), Positives = 264/563 (46%), Gaps = 43/563 (7%) Query: 259 PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYT 318 P A SA+ V +LD NDN+P+F RP+Y+ ++SE+ G A D D GAN+ Y Sbjct: 128 PVAVSAV-EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYE 186 Query: 319 FHQAPEVVRRLLRLDRNTGLI--TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376 + L L N+ ++ ++ +DRE + + A D G +S AQ+ V Sbjct: 187 LSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVR 246 Query: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436 V D NDN+P + + ED T V + SD DEG N G Sbjct: 247 VLDTNDNSPAFD--------QSTYRVQLREDSPPGTLVVKLNASDPDEGSN--------G 290 Query: 437 DVPFQLRQASETGSDSKKKYFLQTTTP-------LDYEKVKDYTIEIVAVDSGNPPLSST 489 ++ + L +S T ++ + + +T LDYE+ Y I + A D G P++ Sbjct: 291 ELRYSL--SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348 Query: 490 NSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE- 548 + V +VDVNDNAP + PEN P ++A ++ +D DSG N ++ LE Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408 Query: 549 PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDN 608 P F S + V LDRE+ Y + V A D G P L T+ V + D NDN Sbjct: 409 PFRLNGFGNSYT---LVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDN 465 Query: 609 DPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQ 661 P F+ Y+ + EN + V D D+ ENA+V S+ + + I Sbjct: 466 PPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSIN 525 Query: 662 NGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNT 721 + +G++ + SFD E+ + ++A D G PP S+ V + V+D ND+AP+I P++T Sbjct: 526 SASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585 Query: 722 SHKL---LTPQTR-LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777 + + P+T G V++V A D DSG NA L Y +A + LF++ H+G I Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTT 645 Query: 778 KEIERRHHGLHRLVVKVSDRGKP 800 +++ L V V D G+P Sbjct: 646 RKMGDESGSTFNLTVVVRDNGEP 668 Score = 200 bits (508), Expect = 7e-51 Identities = 158/502 (31%), Positives = 235/502 (46%), Gaps = 37/502 (7%) Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLR------FSVLAKDRGTNPKSARAQVVVTVKDMN 381 R L LD +G + V +DRE L R VLA NP + A V V + D+N Sbjct: 88 RYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAH----NPVAVSA-VEVEILDIN 142 Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441 DN+P L +SE VA + D D G N+ T ++ F+ Sbjct: 143 DNSPRFPRPNYQL--------QVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFE 194 Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501 L + ++ K L LD E+ + + + AVD G P S T + V+V+D ND Sbjct: 195 LDL--KPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTND 252 Query: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA--AKGLFTISP 559 N+P F QS V E++ PG ++ ++ ASD D GSN EL YSL + + LF+I Sbjct: 253 NSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDA 312 Query: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619 TGE++V LD E+ SY++ V A DRG + G VLV+++D NDN P+ +L+ Sbjct: 313 STGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYS 372 Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTG---TILSSLSFDRE 676 V EN + V +++V D D G N +V L +E + NG G T++ S DRE Sbjct: 373 PVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRL--NGFGNSYTLVVSGPLDRE 430 Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GET 735 + + Y + A DGG+P ++ + + + D NDN P S+ + + L G Sbjct: 431 RVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFL---EDSYSIYIQENNLPGVL 487 Query: 736 VSQVAAEDFDSGVNAELIYSIAGGNPYGL-----FQIGSHSGAITLEKEIERRHHGLHRL 790 + V A D D NAE+ YS+ GL I S SG++ + + Sbjct: 488 LCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFV 547 Query: 791 VVKVSDRGKPPRYGTALVHLYV 812 V+ D+G PP T ++YV Sbjct: 548 TVEAQDKGSPPLSSTVTANVYV 569 Score = 48.1 bits (113), Expect = 4e-05 Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 18/132 (13%) Query: 697 AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA------AEDFDSGVNA 750 A V + +LD NDN+P P+ Q ++ E+V+ A A+D D G N+ Sbjct: 130 AVSAVEVEILDINDNSPRFPRPNY--------QLQVSESVAPGARFHIESAQDPDVGANS 181 Query: 751 ELIYSIAGGNPYGL----FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTA 806 Y ++ + L Q S + L K ++R LH LV+ D G P R GTA Sbjct: 182 VQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTA 241 Query: 807 LVHLYVNETLAN 818 + + V +T N Sbjct: 242 QISVRVLDTNDN 253 >gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens] Length = 1040 Score = 340 bits (872), Expect = 4e-93 Identities = 252/709 (35%), Positives = 359/709 (50%), Gaps = 73/709 (10%) Query: 42 MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDV-----GHLYKLEVGA 96 ++L L LL G +++ Y V EEQ T +G++A D G G Sbjct: 2 IVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRT 61 Query: 97 PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156 PYL ++ +TG ++ E IDRE + C+ Q P C+L EV + + ++ L + +I Sbjct: 62 PYLDLNLETGVLYVNE-KIDREQI--CK-QSPS--CVLHLEVFLENPLE-----LFQVEI 110 Query: 157 EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQEL 216 EV DINDN P+F P +T+ I E+ G+ FP+ A D D G N + YE+ Sbjct: 111 EVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN----SY 166 Query: 217 FGLQV-AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS----------------PP 259 F L V + + +L++ LDRE+ + + DGG PP Sbjct: 167 FSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPP 226 Query: 260 ---RASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIE 316 R +ALL + VLD+NDN P F++P Y L ENSP G VIQ+ A D D+G N E+ Sbjct: 227 QQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVV 286 Query: 317 YTF--HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374 Y+F H +P R L L TG + V G +D E+ + V AKD G N A +V+ Sbjct: 287 YSFSSHISPRA-RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345 Query: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVV 434 V V D NDNAP I + +SE A T VAL V+DRD EN V C + Sbjct: 346 VRVLDANDNAPEISFSTV--------KEAVSEGAAPGTVVALFSVTDRDSEENGQVQCEL 397 Query: 435 AGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKV 494 GDVPF+L+ S K Y + T PLD E YT+ +VA D G P LS++ S++V Sbjct: 398 LGDVPFRLK------SSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQV 451 Query: 495 QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYS-LEPEPAAKG 553 QV DVNDNAP F+Q V +V ENN PG I ++A+D D G+NA+L YS LE + Sbjct: 452 QVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMS 511 Query: 554 LFT---ISPETGEIQVKTSLDREQRESYELKVVAADRGSP-SLQGTATVLVNVLDCNDND 609 +FT I+ E G + S D EQ + + +V A D GSP +L G ATV + ++D NDN Sbjct: 512 VFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNA 571 Query: 610 PKFM--LSGYNFS-VMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQDN--GDFVI 660 P + L G N + E +P + G V +D D GENA++ S+ + N F + Sbjct: 572 PAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRM 631 Query: 661 QNGTGTILSS--LSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707 TG + ++ + R+ Q Y ++ D G PP S+ + + ++D Sbjct: 632 DWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680 Score = 211 bits (536), Expect = 4e-54 Identities = 192/676 (28%), Positives = 296/676 (43%), Gaps = 96/676 (14%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 + + VLD NDN P F P E+SE++ G A D D G N+ +Y Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-----T 162 Query: 326 VRRLLRLDRNT-------GLITVQGPVDREDLSTLRFSVLAKDRG--------------- 363 LD T + ++ P+DRE + R+ + A D G Sbjct: 163 PNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222 Query: 364 ----TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQV 419 ++ A + + V D NDN P + ++ E+ T V + Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFD--------QPVYTVSLPENSPPGTLVIQLNA 274 Query: 420 SDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 479 +D DEG+N V + + +A E S + L+ + LDYE+ Y + + A Sbjct: 275 TDPDEGQNGEVVYSFSSHIS---PRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAK 331 Query: 480 DSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNA 539 D G + + + V+V+D NDNAP + S + A E PG V+A + +D DS N Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391 Query: 540 ELVYSL------EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593 ++ L + + K +TI E LDRE +SY L VVA DRG P+L Sbjct: 392 QVQCELLGDVPFRLKSSFKNYYTIVTEA-------PLDREAGDSYTLTVVARDRGEPALS 444 Query: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVE- 652 + ++ V V D NDN P+F Y+ V EN + + V+ D D+G NAQ+ S+ Sbjct: 445 TSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILE 504 Query: 653 -QDNGDFV-----IQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVL 706 Q G V I + G + + SFD EQ ++FQ++A D G P A T+N+L Sbjct: 505 CQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAG-NATVNIL 563 Query: 707 --DENDNAPYITAP-----SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759 D+NDNAP I AP + ++L G +++VAA D D G NA L YSI G Sbjct: 564 IVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRG 623 Query: 760 NPYGLFQIGSHSGAITLEKEI--ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLA 817 N LF++ +G + + + +R + LV++V D G+PP TA Sbjct: 624 NEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTA----------- 672 Query: 818 NRTLLETLLGHSLDTP--LDIDIAGDPEYERSKQRG--------NILFGVVAGVVAVALL 867 TL+ L+ +++ G E++R + G ++ + G V+ L Sbjct: 673 --TLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFL 730 Query: 868 IALAVLVRYCRQREAK 883 +A+ VL C Q+E K Sbjct: 731 LAMIVLAVRC-QKEKK 745 Score = 184 bits (466), Expect = 5e-46 Identities = 157/525 (29%), Positives = 226/525 (43%), Gaps = 44/525 (8%) Query: 319 FHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS-VLAKDRGTNPKSARAQVVVTV 377 F P L L+ TG++ V +DRE + S VL + QV + V Sbjct: 53 FQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEV 112 Query: 378 KDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGD 437 D+NDN P+ D ISE T L D D G N+ + + Sbjct: 113 LDINDNPPSFP--------EPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN 164 Query: 438 VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGN-------------- 483 F L +T D + L PLD E+ + + AVD G Sbjct: 165 SYFSLDV--QTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222 Query: 484 --PPL---SSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538 PP + T L ++V+D NDN P F Q V V+ PEN+ PG ++ ++ A+D D G N Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQN 282 Query: 539 AELVYSLEPE--PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596 E+VYS P A+ LF +SP TG ++V LD E+ Y++ V A D G ++ Sbjct: 283 GEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHC 342 Query: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG 656 VLV VLD NDN P+ S +V E + V + +V D D EN QVQ + D Sbjct: 343 KVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV- 401 Query: 657 DFVIQNGTG---TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713 F +++ TI++ DRE +YT + A D G P S + + V D NDNAP Sbjct: 402 PFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAP 461 Query: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS-----IAGGNPYGLFQIG 768 + P + +T G + V+A D D G NA+L YS I G + + I Sbjct: 462 RFSQPVYDVY--VTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSIN 519 Query: 769 SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRY-GTALVHLYV 812 S +G + + + V+ D G P G A V++ + Sbjct: 520 SENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILI 564 >gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens] Length = 896 Score = 340 bits (872), Expect = 4e-93 Identities = 252/709 (35%), Positives = 359/709 (50%), Gaps = 73/709 (10%) Query: 42 MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDV-----GHLYKLEVGA 96 ++L L LL G +++ Y V EEQ T +G++A D G G Sbjct: 2 IVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRT 61 Query: 97 PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156 PYL ++ +TG ++ E IDRE + C+ Q P C+L EV + + ++ L + +I Sbjct: 62 PYLDLNLETGVLYVNE-KIDREQI--CK-QSPS--CVLHLEVFLENPLE-----LFQVEI 110 Query: 157 EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQEL 216 EV DINDN P+F P +T+ I E+ G+ FP+ A D D G N + YE+ Sbjct: 111 EVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN----SY 166 Query: 217 FGLQV-AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS----------------PP 259 F L V + + +L++ LDRE+ + + DGG PP Sbjct: 167 FSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPP 226 Query: 260 ---RASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIE 316 R +ALL + VLD+NDN P F++P Y L ENSP G VIQ+ A D D+G N E+ Sbjct: 227 QQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVV 286 Query: 317 YTF--HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374 Y+F H +P R L L TG + V G +D E+ + V AKD G N A +V+ Sbjct: 287 YSFSSHISPRA-RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345 Query: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVV 434 V V D NDNAP I + +SE A T VAL V+DRD EN V C + Sbjct: 346 VRVLDANDNAPEISFSTV--------KEAVSEGAAPGTVVALFSVTDRDSEENGQVQCEL 397 Query: 435 AGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKV 494 GDVPF+L+ S K Y + T PLD E YT+ +VA D G P LS++ S++V Sbjct: 398 LGDVPFRLK------SSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQV 451 Query: 495 QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYS-LEPEPAAKG 553 QV DVNDNAP F+Q V +V ENN PG I ++A+D D G+NA+L YS LE + Sbjct: 452 QVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMS 511 Query: 554 LFT---ISPETGEIQVKTSLDREQRESYELKVVAADRGSP-SLQGTATVLVNVLDCNDND 609 +FT I+ E G + S D EQ + + +V A D GSP +L G ATV + ++D NDN Sbjct: 512 VFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNA 571 Query: 610 PKFM--LSGYNFS-VMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQDN--GDFVI 660 P + L G N + E +P + G V +D D GENA++ S+ + N F + Sbjct: 572 PAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRM 631 Query: 661 QNGTGTILSS--LSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707 TG + ++ + R+ Q Y ++ D G PP S+ + + ++D Sbjct: 632 DWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680 Score = 211 bits (536), Expect = 4e-54 Identities = 192/676 (28%), Positives = 296/676 (43%), Gaps = 96/676 (14%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 + + VLD NDN P F P E+SE++ G A D D G N+ +Y Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-----T 162 Query: 326 VRRLLRLDRNT-------GLITVQGPVDREDLSTLRFSVLAKDRG--------------- 363 LD T + ++ P+DRE + R+ + A D G Sbjct: 163 PNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222 Query: 364 ----TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQV 419 ++ A + + V D NDN P + ++ E+ T V + Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFD--------QPVYTVSLPENSPPGTLVIQLNA 274 Query: 420 SDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 479 +D DEG+N V + + +A E S + L+ + LDYE+ Y + + A Sbjct: 275 TDPDEGQNGEVVYSFSSHIS---PRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAK 331 Query: 480 DSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNA 539 D G + + + V+V+D NDNAP + S + A E PG V+A + +D DS N Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391 Query: 540 ELVYSL------EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593 ++ L + + K +TI E LDRE +SY L VVA DRG P+L Sbjct: 392 QVQCELLGDVPFRLKSSFKNYYTIVTEA-------PLDREAGDSYTLTVVARDRGEPALS 444 Query: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVE- 652 + ++ V V D NDN P+F Y+ V EN + + V+ D D+G NAQ+ S+ Sbjct: 445 TSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILE 504 Query: 653 -QDNGDFV-----IQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVL 706 Q G V I + G + + SFD EQ ++FQ++A D G P A T+N+L Sbjct: 505 CQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAG-NATVNIL 563 Query: 707 --DENDNAPYITAP-----SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759 D+NDNAP I AP + ++L G +++VAA D D G NA L YSI G Sbjct: 564 IVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRG 623 Query: 760 NPYGLFQIGSHSGAITLEKEI--ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLA 817 N LF++ +G + + + +R + LV++V D G+PP TA Sbjct: 624 NEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTA----------- 672 Query: 818 NRTLLETLLGHSLDTP--LDIDIAGDPEYERSKQRG--------NILFGVVAGVVAVALL 867 TL+ L+ +++ G E++R + G ++ + G V+ L Sbjct: 673 --TLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFL 730 Query: 868 IALAVLVRYCRQREAK 883 +A+ VL C Q+E K Sbjct: 731 LAMIVLAVRC-QKEKK 745 Score = 184 bits (466), Expect = 5e-46 Identities = 157/525 (29%), Positives = 226/525 (43%), Gaps = 44/525 (8%) Query: 319 FHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS-VLAKDRGTNPKSARAQVVVTV 377 F P L L+ TG++ V +DRE + S VL + QV + V Sbjct: 53 FQTVPNSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEV 112 Query: 378 KDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGD 437 D+NDN P+ D ISE T L D D G N+ + + Sbjct: 113 LDINDNPPSFP--------EPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPN 164 Query: 438 VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGN-------------- 483 F L +T D + L PLD E+ + + AVD G Sbjct: 165 SYFSLDV--QTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222 Query: 484 --PPL---SSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538 PP + T L ++V+D NDN P F Q V V+ PEN+ PG ++ ++ A+D D G N Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQN 282 Query: 539 AELVYSLEPE--PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596 E+VYS P A+ LF +SP TG ++V LD E+ Y++ V A D G ++ Sbjct: 283 GEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHC 342 Query: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG 656 VLV VLD NDN P+ S +V E + V + +V D D EN QVQ + D Sbjct: 343 KVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV- 401 Query: 657 DFVIQNGTG---TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713 F +++ TI++ DRE +YT + A D G P S + + V D NDNAP Sbjct: 402 PFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAP 461 Query: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS-----IAGGNPYGLFQIG 768 + P + +T G + V+A D D G NA+L YS I G + + I Sbjct: 462 RFSQPVYDVY--VTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSIN 519 Query: 769 SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRY-GTALVHLYV 812 S +G + + + V+ D G P G A V++ + Sbjct: 520 SENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILI 564 >gi|11036656 protocadherin beta 7 precursor [Homo sapiens] Length = 793 Score = 340 bits (871), Expect = 5e-93 Identities = 238/703 (33%), Positives = 355/703 (50%), Gaps = 53/703 (7%) Query: 35 QRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKL-- 92 +R + +L L + L S A + Y V EE T + +LA D G VG L Sbjct: 6 ERAVQKRQVLFLCVFLGMSWAGAEPLRYFVAEETERGTFLTNLAKDLGL-GVGELRARGT 64 Query: 93 ----EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGS 148 + L + TGD+ E +DRE L C P +PC+L F++ + Q Sbjct: 65 RIVSDQNMQILLLSSLTGDLLLNE-KLDREEL--CG---PREPCVLPFQLLLEKPFQ--- 115 Query: 149 PRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ 208 + ++ V+DIND+ P F I+L I E+T G+ F + A D D G N +++Y + Sbjct: 116 --IFRAELWVRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTIS 173 Query: 209 AGPEAQELFGLQVAEDQEEK-QPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLR 267 P A F + V + E P+L++ LDRE + LT+ DGGSPPR+ +AL+R Sbjct: 174 --PNAY--FHINVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVR 229 Query: 268 VTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVR 327 + VLD NDNAP F R Y+ ++ ENSP+G V+ V A D D G+N EI Y F A E + Sbjct: 230 ILVLDVNDNAPDFVRSLYKVQVPENSPVGSMVVSVSARDLDTGSNGEIAYAFSYATERIL 289 Query: 328 RLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387 + +++ +G + ++ +D E + T ++ AKD G S + VVV V D+NDN P + Sbjct: 290 KTFQINPTSGSLHLKAQLDYEAIQTYTLTIQAKDGG--GLSGKCTVVVDVTDINDNRPEL 347 Query: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447 + + + I+E+ + ET VA+ ++ DRD G N C + DVPF L+ + E Sbjct: 348 LLSSL--------TSPIAEN-SPETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVE 398 Query: 448 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507 Y L T PLD E+ +Y I I D G P L + +++ V V DVNDNAP FT Sbjct: 399 ------NFYTLVTEKPLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFT 452 Query: 508 QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL----EPEPAAKGLFTISPETGE 563 Q+ + ENN P I ++A+D DSG+NA+++YSL +P L +I+ + G Sbjct: 453 QTSYTLFVRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGH 512 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV-- 621 + SLD E +++E +V A DRGSP+L A V V VLD NDN P + N S Sbjct: 513 LFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPC 572 Query: 622 MENMPALSPVG----MVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSFDR 675 E +P + G V +DGD G+NA QL + G F + G + ++ Sbjct: 573 TEPLPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSE 632 Query: 676 EQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718 + + D G PPRSA + + ++D + PY+ P Sbjct: 633 RDAAKQRLVVLVKDNGEPPRSATATLHVLLVD-GFSQPYLRLP 674 Score = 224 bits (570), Expect = 4e-58 Identities = 174/566 (30%), Positives = 255/566 (45%), Gaps = 53/566 (9%) Query: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329 V D ND+AP F ++ E++ G + + A DSD G N+ YT +P + Sbjct: 123 VRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTI--SPNAYFHI 180 Query: 330 LRLDRNTGLI----TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385 D G I + +DRE++ ++ A D G+ P+S A V + V D+NDNAP Sbjct: 181 NVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILVLDVNDNAP 240 Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445 +R + V + E+ + V V D D G N G++ + A Sbjct: 241 DF-VRSLYKV-------QVPENSPVGSMVVSVSARDLDTGSN--------GEIAYAFSYA 284 Query: 446 SE----TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501 +E T + L LDYE ++ YT+ I A D G LS ++ V V D+ND Sbjct: 285 TERILKTFQINPTSGSLHLKAQLDYEAIQTYTLTIQAKDGGG--LSGKCTVVVDVTDIND 342 Query: 502 NAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE------PAAKGLF 555 N P S EN+ P V+A D DSG+N + V S++ + P+ + + Sbjct: 343 NRPELLLSSLTSPIAENS-PETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVENFY 401 Query: 556 TISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS 615 T+ E LDRE+ Y + + D G+P L+ + V V D NDN P F + Sbjct: 402 TLVTEK-------PLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQT 454 Query: 616 GYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQNGTGTIL 668 Y V EN P+G V+ D D G NAQV S+ + I G + Sbjct: 455 SYTLFVRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGHLF 514 Query: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP-SNTSHKLLT 727 + S D E + F++ A D G P S+ V + VLD NDN+P++ P N+S Sbjct: 515 ALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPCTE 574 Query: 728 PQTRLGET---VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRH 784 P R E V++V A D DSG NA L Y + GLF + +H+G + + + R Sbjct: 575 PLPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERD 634 Query: 785 HGLHRLVVKVSDRGKPPRYGTALVHL 810 RLVV V D G+PPR TA +H+ Sbjct: 635 AAKQRLVVLVKDNGEPPRSATATLHV 660 Score = 40.8 bits (94), Expect = 0.007 Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 12/115 (10%) Query: 705 VLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGL 764 V D ND+AP + S K+L T G +A+D D G N+ Y+I+ P Sbjct: 123 VRDINDHAP-VFLDREISLKILESTTP-GAAFLLESAQDSDVGTNSLSNYTIS---PNAY 177 Query: 765 FQIGSHSGA-------ITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812 F I H + L + ++R L + D G PPR GTALV + V Sbjct: 178 FHINVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILV 232 >gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor [Homo sapiens] Length = 818 Score = 338 bits (868), Expect = 1e-92 Identities = 232/685 (33%), Positives = 352/685 (51%), Gaps = 56/685 (8%) Query: 31 GPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL- 89 G G+ LP + L LL L P+ R Y++PEE P +++G+LA D GF V L Sbjct: 6 GELGRAERLPVLFLFLLSLFCPALCEQIR--YRIPEEMPKGSVVGNLATDLGF-SVQELP 62 Query: 90 -YKLEVGA--PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146 KL V + PY V ++G++ + + +DRE E + P C LEFE V Sbjct: 63 TRKLRVSSEKPYFTVSAESGELLVS-SRLDRE---EICGKKPA--CALEFEA-----VAE 111 Query: 147 GSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206 +E++DIND+TP F L I E+ G+ F + +A D D G N + Y+ Sbjct: 112 NPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYK 171 Query: 207 LQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL 265 L P F L + E Q+ K P+L + LDRE+ + L + DGG PP + + Sbjct: 172 LSLNPS----FSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTE 227 Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 LR+ V D NDN P F R Y L EN P G +V+QV A D D+G N+EI Y+F++ ++ Sbjct: 228 LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI 287 Query: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385 L+ +G IT Q +D E+ T +S++ + R A+ V + ++D NDN+P Sbjct: 288 ----FSLNSKSGEITTQKKLDFEE--TKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSP 341 Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445 + + + I E+ T +AL+++ D+D GEN V C + G+VPF++ Sbjct: 342 EVTFHSL--------LEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKII-- 391 Query: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505 S SK Y L T LD E+ +Y + I A D G PPLSS+ S+ + + DVNDNAPV Sbjct: 392 ----SSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPV 447 Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL---EPEPAAKGLF-TISPET 561 F Q+ V+ PENN PG IA++ ASD D G N ++ YS+ + EP A + ++S ++ Sbjct: 448 FHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507 Query: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYN 618 G + + + D EQ ++EL + A D+GSP+L ++ V V D NDN P+ + L Sbjct: 508 GVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDG 567 Query: 619 FSVMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLS 672 ++ + +P + G V +D D G NA + V Q + G F + TG + ++ + Sbjct: 568 SALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARA 627 Query: 673 FDREQQSTYTFQLKAVDGGVPPRSA 697 + + DGG PP SA Sbjct: 628 LGDRDAARQRLLVAVRDGGQPPLSA 652 Score = 239 bits (611), Expect = 8e-63 Identities = 186/626 (29%), Positives = 300/626 (47%), Gaps = 56/626 (8%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 + V + D ND+ PKF + S+E ++SE++ G I A D+D G N+ +Y P Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSF 178 Query: 326 VRRLLRLDRNTGL----ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMN 381 L+ ++ G + ++ +DRE S R + A D G P S ++ + V D N Sbjct: 179 --SLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDAN 236 Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441 DN P R + V+ + E+V T V V +D+DEG N+ +T + Sbjct: 237 DNPPVFN-RDVYRVS-------LRENVPPGTTVLQVSATDQDEGINSEIT--------YS 280 Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501 + + S + K + T LD+E+ K+Y++ + D G L + ++++ + D ND Sbjct: 281 FYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDEND 338 Query: 502 NAPVFT-QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560 N+P T S+ E+ EN PG +IA I D DSG N E+ L+ E K + + S Sbjct: 339 NSPEVTFHSLLEMIL-ENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFK-IISSSKN 396 Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620 + ++ +LDREQ Y + + A DRG P L + +V++++ D NDN P F + Y S Sbjct: 397 SYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVS 456 Query: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN------GDFVIQNG-TGTILSSLSF 673 V EN P + + V D D G N QV S+ + +V + +G + + +F Sbjct: 457 VPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAF 516 Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTP 728 D EQ T+ L+A D G P SA V + + V D NDNAP + P+ + ++ Sbjct: 517 DYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576 Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788 G V++V A D DSG NA L Y + + GLF +G +G + + + R Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQ 636 Query: 789 RLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSK 848 RL+V V D G+PP TA +HL ++ L+ +L D P + DP+ E Sbjct: 637 RLLVAVRDGGQPPLSATATLHLVFADS------LQEVLPDITDRP----VPSDPQAE--- 683 Query: 849 QRGNILFGVVAGVVAVALLIALAVLV 874 + F +V + +++L LAV++ Sbjct: 684 ----LQFYLVVALALISVLFLLAVIL 705 Score = 48.5 bits (114), Expect = 3e-05 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 45/239 (18%) Query: 56 HATRVVYKVPEEQPPNTLIGSLAA---DYGFPD-------VGHLYKLEVGAPYLRVDGKT 105 H + VPE PP I + A D G L L + A Y+ + ++ Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL-ASYVSMSAQS 507 Query: 106 GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIN 162 G +F + + D E LR FE+++ Q GSP L ++ V D N Sbjct: 508 GVVFA-QRAFDYEQLRT-------------FELTLQARDQ-GSPALSANVSLRVLVGDRN 552 Query: 163 DNTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQ 214 DN P P + +P G L +A D D+G N SY LQA Sbjct: 553 DNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL 612 Query: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273 GL+ E + + +G+ D R L + V+DGG PP +++A L + D+ Sbjct: 613 FSLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLVFADS 663 >gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor [Homo sapiens] Length = 923 Score = 338 bits (868), Expect = 1e-92 Identities = 232/685 (33%), Positives = 352/685 (51%), Gaps = 56/685 (8%) Query: 31 GPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL- 89 G G+ LP + L LL L P+ R Y++PEE P +++G+LA D GF V L Sbjct: 6 GELGRAERLPVLFLFLLSLFCPALCEQIR--YRIPEEMPKGSVVGNLATDLGF-SVQELP 62 Query: 90 -YKLEVGA--PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146 KL V + PY V ++G++ + + +DRE E + P C LEFE V Sbjct: 63 TRKLRVSSEKPYFTVSAESGELLVS-SRLDRE---EICGKKPA--CALEFEA-----VAE 111 Query: 147 GSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206 +E++DIND+TP F L I E+ G+ F + +A D D G N + Y+ Sbjct: 112 NPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYK 171 Query: 207 LQAGPEAQELFGLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL 265 L P F L + E Q+ K P+L + LDRE+ + L + DGG PP + + Sbjct: 172 LSLNPS----FSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTE 227 Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 LR+ V D NDN P F R Y L EN P G +V+QV A D D+G N+EI Y+F++ ++ Sbjct: 228 LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI 287 Query: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385 L+ +G IT Q +D E+ T +S++ + R A+ V + ++D NDN+P Sbjct: 288 ----FSLNSKSGEITTQKKLDFEE--TKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSP 341 Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445 + + + I E+ T +AL+++ D+D GEN V C + G+VPF++ Sbjct: 342 EVTFHSL--------LEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKII-- 391 Query: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505 S SK Y L T LD E+ +Y + I A D G PPLSS+ S+ + + DVNDNAPV Sbjct: 392 ----SSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPV 447 Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL---EPEPAAKGLF-TISPET 561 F Q+ V+ PENN PG IA++ ASD D G N ++ YS+ + EP A + ++S ++ Sbjct: 448 FHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507 Query: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYN 618 G + + + D EQ ++EL + A D+GSP+L ++ V V D NDN P+ + L Sbjct: 508 GVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDG 567 Query: 619 FSVMENMPALSPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLS 672 ++ + +P + G V +D D G NA + V Q + G F + TG + ++ + Sbjct: 568 SALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARA 627 Query: 673 FDREQQSTYTFQLKAVDGGVPPRSA 697 + + DGG PP SA Sbjct: 628 LGDRDAARQRLLVAVRDGGQPPLSA 652 Score = 239 bits (611), Expect = 8e-63 Identities = 186/626 (29%), Positives = 300/626 (47%), Gaps = 56/626 (8%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 + V + D ND+ PKF + S+E ++SE++ G I A D+D G N+ +Y P Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSF 178 Query: 326 VRRLLRLDRNTGL----ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMN 381 L+ ++ G + ++ +DRE S R + A D G P S ++ + V D N Sbjct: 179 --SLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDAN 236 Query: 382 DNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ 441 DN P R + V+ + E+V T V V +D+DEG N+ +T + Sbjct: 237 DNPPVFN-RDVYRVS-------LRENVPPGTTVLQVSATDQDEGINSEIT--------YS 280 Query: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501 + + S + K + T LD+E+ K+Y++ + D G L + ++++ + D ND Sbjct: 281 FYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDEND 338 Query: 502 NAPVFT-QSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560 N+P T S+ E+ EN PG +IA I D DSG N E+ L+ E K + + S Sbjct: 339 NSPEVTFHSLLEMIL-ENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFK-IISSSKN 396 Query: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620 + ++ +LDREQ Y + + A DRG P L + +V++++ D NDN P F + Y S Sbjct: 397 SYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVS 456 Query: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN------GDFVIQNG-TGTILSSLSF 673 V EN P + + V D D G N QV S+ + +V + +G + + +F Sbjct: 457 VPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAF 516 Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTP 728 D EQ T+ L+A D G P SA V + + V D NDNAP + P+ + ++ Sbjct: 517 DYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576 Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788 G V++V A D DSG NA L Y + + GLF +G +G + + + R Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQ 636 Query: 789 RLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSK 848 RL+V V D G+PP TA +HL ++ L+ +L D P + DP+ E Sbjct: 637 RLLVAVRDGGQPPLSATATLHLVFADS------LQEVLPDITDRP----VPSDPQAE--- 683 Query: 849 QRGNILFGVVAGVVAVALLIALAVLV 874 + F +V + +++L LAV++ Sbjct: 684 ----LQFYLVVALALISVLFLLAVIL 705 Score = 48.5 bits (114), Expect = 3e-05 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 45/239 (18%) Query: 56 HATRVVYKVPEEQPPNTLIGSLAA---DYGFPD-------VGHLYKLEVGAPYLRVDGKT 105 H + VPE PP I + A D G L L + A Y+ + ++ Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL-ASYVSMSAQS 507 Query: 106 GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIN 162 G +F + + D E LR FE+++ Q GSP L ++ V D N Sbjct: 508 GVVFA-QRAFDYEQLRT-------------FELTLQARDQ-GSPALSANVSLRVLVGDRN 552 Query: 163 DNTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQ 214 DN P P + +P G L +A D D+G N SY LQA Sbjct: 553 DNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL 612 Query: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273 GL+ E + + +G+ D R L + V+DGG PP +++A L + D+ Sbjct: 613 FSLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLVFADS 663 >gi|9256604 protocadherin beta 11 precursor [Homo sapiens] Length = 797 Score = 338 bits (867), Expect = 2e-92 Identities = 237/703 (33%), Positives = 360/703 (51%), Gaps = 51/703 (7%) Query: 34 GQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFP-----DVGH 88 G R +L L +LL S + + V EE + +G+LA D G G Sbjct: 5 GTRTQQIRQVLLLFVLLGMSQAGSETWSFSVAEEMQSGSFVGNLAKDLGLKVRELSSRGA 64 Query: 89 LYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGS 148 L++D TGD+ +ET +DRE L C + +PC+L +V L+QN + Sbjct: 65 RVVSNDKKQRLQLDINTGDLLLSET-LDREEL--CGSI---EPCVLHLQV----LMQNPT 114 Query: 149 PRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ 208 + L+ +++V+DIND++P F+ + L IPEN+ +G++F + A D D G N V SY + Sbjct: 115 -QFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTIS 173 Query: 209 AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268 P + ++V D K P+L++ LD E + DGGSPPR+ +AL+RV Sbjct: 174 --PNSHFHIKMRVIPDNR-KYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRV 230 Query: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRR 328 V+D NDN+P+FE+ YE ++ ENS +G ++ V A D D G N EI YTF A E +R+ Sbjct: 231 VVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRK 290 Query: 329 LLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIE 388 +++ +G IT++ P+D E + + + A D G ++ V++ V D+NDNAP I Sbjct: 291 TFEINQKSGEITLRAPLDFETIESYSIIIQATDGG--GLFGKSTVIIHVIDVNDNAPEIT 348 Query: 389 IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448 + I + I E+ ET V + + D D G+N + C + D+PF L+ + E Sbjct: 349 VSSI--------TSPIPEN-TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVE- 398 Query: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508 Y L+T PLD E +Y I I D G P L + ++ V V DVNDNAP FTQ Sbjct: 399 -----NYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQ 453 Query: 509 SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE-----PAAKGLFTISPETGE 563 + + ENN P I ++A+D DSG+NA++ YSL P P A L +I+ + G Sbjct: 454 TSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLA-SLVSINTDNGH 512 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV-- 621 + SLD E ++++ +V A DRGSP+L A V V VLD NDN P + N S Sbjct: 513 LFALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPC 572 Query: 622 MENMPALSPVG----MVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSFDR 675 E +P + G V +DGD G+NA QL + G F + G + ++ Sbjct: 573 TELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSE 632 Query: 676 EQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718 + + + D G PPRSA + + ++D + PY+ P Sbjct: 633 RDAAKHRLVVLVKDNGEPPRSATATLQVLLVD-GFSQPYLPLP 674 Score = 236 bits (601), Expect = 1e-61 Identities = 190/633 (30%), Positives = 275/633 (43%), Gaps = 44/633 (6%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE- 324 + + V D ND++P F E+ ENSP+G + A D D G NA YT Sbjct: 119 IELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTISPNSHF 178 Query: 325 -VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 + R++ +R + + +D E+L L F + A D G+ P+S A V V V D+NDN Sbjct: 179 HIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVDINDN 238 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 +P E + I E+ + + +V D D G N + C +R Sbjct: 239 SPEFEQAFYEV--------KIRENSILGSLILIVSAWDLDSGTNGEI-CYTFSHASEDIR 289 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 + E S + + PLD+E ++ Y+I I A D G L +++ + V+DVNDNA Sbjct: 290 KTFEINQKSGE---ITLRAPLDFETIESYSIIIQATDGGG--LFGKSTVIIHVIDVNDNA 344 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 P T S PEN P V+ + D DSG N +V S+ PE L + Sbjct: 345 PEITVSSITSPIPENT-PETVVMVFSIQDIDSGDNGRIVCSI-PEDLPFVLKSSVENYYT 402 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 ++ + LDRE Y + + D G P L+ V V D NDN P F + Y V E Sbjct: 403 LETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTLFVRE 462 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQNGTGTILSSLSFDRE 676 N +G V+ D D G NAQV S+ + I G + + S D E Sbjct: 463 NNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHLFALRSLDYE 522 Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP----SNTSHKLLTPQTRL 732 + F++ A D G P S+ V + VLD NDN+P++ P S +L+ Sbjct: 523 ALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEP 582 Query: 733 GETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVV 792 G V++V A D DSG NA L Y + GLF + +H+G + + + R HRLVV Sbjct: 583 GYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVV 642 Query: 793 KVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGN 852 V D G+PPR TA L+ LL P P ++ Sbjct: 643 LVKDNGEPPRSATA--------------TLQVLLVDGFSQPYLPLPEAAPAQAQADSLTV 688 Query: 853 ILFGVVAGVVAVALL-IALAVLVRYCRQREAKS 884 L +A V ++ L + L V VR CR+ A S Sbjct: 689 YLVVALASVSSLFLFSVLLFVAVRLCRRSRAAS 721 >gi|11128035 protocadherin gamma subfamily B, 2 isoform 1 precursor [Homo sapiens] Length = 931 Score = 334 bits (856), Expect = 3e-91 Identities = 235/675 (34%), Positives = 339/675 (50%), Gaps = 53/675 (7%) Query: 42 MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL--YKLEVGAP-- 97 +LL LL L P ++ Y +PEE N+++G+LA D G V L KL V A Sbjct: 16 VLLPFLLSLFPG-ALPVQIRYSIPEELAKNSVVGNLAKDLGL-SVRDLPARKLRVSAEKE 73 Query: 98 YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIE 157 Y V+ ++GD+ ++ IDRE + C Q C+L+F D V + + Sbjct: 74 YFTVNPESGDLLVSDR-IDREQI--CGKQ---PLCVLDF-----DTVAENPLNIFYIAVI 122 Query: 158 VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF 217 VQDINDNTP F I L I E+T G+ FP+ A D D GPN + Y L E F Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDN----EYF 178 Query: 218 GLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDN 276 L + + K P+LI+ +LDRE + L + DGG PP++ + +R+ V D NDN Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238 Query: 277 APKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNT 336 P F + Y L E+ P G V+QV A D D+G NAEI Y+FH E V+ L+ T Sbjct: 239 PPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKT 298 Query: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396 G IT + +D E S+ S+ AKD G +A + V + D ND AP + + + Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVS--- 353 Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456 + ED T +AL++ DRD GEN V C V G+ F L+ S SK Y Sbjct: 354 -----TPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILK------SSSKNYY 402 Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516 L T LD E++ +Y + I A D G PPLSS+ + + + DVNDNAPVF Q+ V Sbjct: 403 KLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVA 462 Query: 517 ENNKPGEVIAEITASDADSGSNAELVYS-----LEPEPAAKGLFTISPETGEIQVKTSLD 571 ENN PG IA+I+ASD D G + ++ YS L+P ++S ++G + + + D Sbjct: 463 ENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREIL-SYVSVSAQSGVVFAQRAFD 521 Query: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYNFSVMENMPAL 628 EQ ++EL + A D+GSP+L ++ V V D NDN P+ + L ++ + +P Sbjct: 522 HEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRA 581 Query: 629 SPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLSFDREQQSTYT 682 + G V +D D G NA + V Q + G F + TG + ++ + + Sbjct: 582 AEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQR 641 Query: 683 FQLKAVDGGVPPRSA 697 + DGG PP SA Sbjct: 642 LLVAVRDGGQPPLSA 656 Score = 221 bits (563), Expect = 3e-57 Identities = 189/665 (28%), Positives = 298/665 (44%), Gaps = 54/665 (8%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP-- 323 + V V D NDN P F++ ++ E++ G + A DSD G N+ Y + Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 ++ + R + ++ +DRE+ S + + A D G P+S Q+ + V D NDN Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P + + VT + EDV V V +DRDEG NA +T +V Q++ Sbjct: 239 PPVFS-QDVYRVT-------LREDVPPGFFVLQVTATDRDEGINAEITYSFH-NVDEQVK 289 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++K + T LD+E YT+ I A D G+ L++ S++V+++D ND A Sbjct: 290 HFFNL---NEKTGEITTKDDLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 P + PE++ PG VIA I D DSG N E VY A L + S + Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGE-VYCQVLGNAKFILKSSSKNYYK 403 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + +LDRE+ Y L + A D G P L + V +++ D NDN P F + Y V E Sbjct: 404 LVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAE 463 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-------GDFVIQNGTGTILSSLSFDRE 676 N P + + ++ D D G + QV S+ + + +G + + +FD E Sbjct: 464 NNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE 523 Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTPQTR 731 Q + L+A D G P SA V + + V D NDNAP + P+ + ++ Sbjct: 524 QLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAE 583 Query: 732 LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791 G V++V A D DSG NA L Y + + GLF +G +G + + + R RL+ Sbjct: 584 PGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLL 643 Query: 792 VKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRG 851 V V D G+PP TA +HL ++L + +L L E S + Sbjct: 644 VAVRDGGQPPLSATATLHLIFADSL--QEVLPDL---------------SDRREPSDPQA 686 Query: 852 NILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKG--- 908 + F +V + +++L LAV++ + S + + D + P S K G Sbjct: 687 KLQFYLVVALALISVLFFLAVILAISLRLRLSS-----RSDAWDCFQPGLSSKPGPGVLP 741 Query: 909 NKSKG 913 N S+G Sbjct: 742 NYSEG 746 Score = 49.7 bits (117), Expect = 1e-05 Identities = 61/238 (25%), Positives = 95/238 (39%), Gaps = 47/238 (19%) Query: 58 TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGA-----------PYLRVDGKTG 106 T + V E PP I ++A PD+G ++ Y+ V ++G Sbjct: 455 TSYMVHVAENNPPGASIAQISASD--PDLGPSGQVSYSIVASDLKPREILSYVSVSAQSG 512 Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIND 163 +F + + D E LR FE+++ Q GSP L ++ V D+ND Sbjct: 513 VVFA-QRAFDHEQLRA-------------FELTLQARDQ-GSPALSANVSLRVLVGDLND 557 Query: 164 NTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQE 215 N P P + +P G L +A D D+G N SY LQA Sbjct: 558 NAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLF 617 Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273 GL+ E + + +G+ D R L + V+DGG PP +++A L + D+ Sbjct: 618 SLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLIFADS 667 >gi|14270493 protocadherin gamma subfamily B, 2 isoform 2 precursor [Homo sapiens] Length = 811 Score = 334 bits (856), Expect = 3e-91 Identities = 235/675 (34%), Positives = 339/675 (50%), Gaps = 53/675 (7%) Query: 42 MLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHL--YKLEVGAP-- 97 +LL LL L P ++ Y +PEE N+++G+LA D G V L KL V A Sbjct: 16 VLLPFLLSLFPG-ALPVQIRYSIPEELAKNSVVGNLAKDLGL-SVRDLPARKLRVSAEKE 73 Query: 98 YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIE 157 Y V+ ++GD+ ++ IDRE + C Q C+L+F D V + + Sbjct: 74 YFTVNPESGDLLVSDR-IDREQI--CGKQ---PLCVLDF-----DTVAENPLNIFYIAVI 122 Query: 158 VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF 217 VQDINDNTP F I L I E+T G+ FP+ A D D GPN + Y L E F Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDN----EYF 178 Query: 218 GLQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDN 276 L + + K P+LI+ +LDRE + L + DGG PP++ + +R+ V D NDN Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238 Query: 277 APKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNT 336 P F + Y L E+ P G V+QV A D D+G NAEI Y+FH E V+ L+ T Sbjct: 239 PPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKT 298 Query: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396 G IT + +D E S+ S+ AKD G +A + V + D ND AP + + + Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVS--- 353 Query: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456 + ED T +AL++ DRD GEN V C V G+ F L+ S SK Y Sbjct: 354 -----TPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILK------SSSKNYY 402 Query: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516 L T LD E++ +Y + I A D G PPLSS+ + + + DVNDNAPVF Q+ V Sbjct: 403 KLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVA 462 Query: 517 ENNKPGEVIAEITASDADSGSNAELVYS-----LEPEPAAKGLFTISPETGEIQVKTSLD 571 ENN PG IA+I+ASD D G + ++ YS L+P ++S ++G + + + D Sbjct: 463 ENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREIL-SYVSVSAQSGVVFAQRAFD 521 Query: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM---LSGYNFSVMENMPAL 628 EQ ++EL + A D+GSP+L ++ V V D NDN P+ + L ++ + +P Sbjct: 522 HEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRA 581 Query: 629 SPVG----MVTVIDGDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLSFDREQQSTYT 682 + G V +D D G NA + V Q + G F + TG + ++ + + Sbjct: 582 AEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQR 641 Query: 683 FQLKAVDGGVPPRSA 697 + DGG PP SA Sbjct: 642 LLVAVRDGGQPPLSA 656 Score = 221 bits (563), Expect = 3e-57 Identities = 189/665 (28%), Positives = 298/665 (44%), Gaps = 54/665 (8%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP-- 323 + V V D NDN P F++ ++ E++ G + A DSD G N+ Y + Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178 Query: 324 EVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 ++ + R + ++ +DRE+ S + + A D G P+S Q+ + V D NDN Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDN 238 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 P + + VT + EDV V V +DRDEG NA +T +V Q++ Sbjct: 239 PPVFS-QDVYRVT-------LREDVPPGFFVLQVTATDRDEGINAEITYSFH-NVDEQVK 289 Query: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503 ++K + T LD+E YT+ I A D G+ L++ S++V+++D ND A Sbjct: 290 HFFNL---NEKTGEITTKDDLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344 Query: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563 P + PE++ PG VIA I D DSG N E VY A L + S + Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGE-VYCQVLGNAKFILKSSSKNYYK 403 Query: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623 + +LDRE+ Y L + A D G P L + V +++ D NDN P F + Y V E Sbjct: 404 LVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAE 463 Query: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-------GDFVIQNGTGTILSSLSFDRE 676 N P + + ++ D D G + QV S+ + + +G + + +FD E Sbjct: 464 NNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE 523 Query: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPS-----NTSHKLLTPQTR 731 Q + L+A D G P SA V + + V D NDNAP + P+ + ++ Sbjct: 524 QLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAE 583 Query: 732 LGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791 G V++V A D DSG NA L Y + + GLF +G +G + + + R RL+ Sbjct: 584 PGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLL 643 Query: 792 VKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRG 851 V V D G+PP TA +HL ++L + +L L E S + Sbjct: 644 VAVRDGGQPPLSATATLHLIFADSL--QEVLPDL---------------SDRREPSDPQA 686 Query: 852 NILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSGKASKG--- 908 + F +V + +++L LAV++ + S + + D + P S K G Sbjct: 687 KLQFYLVVALALISVLFFLAVILAISLRLRLSS-----RSDAWDCFQPGLSSKPGPGVLP 741 Query: 909 NKSKG 913 N S+G Sbjct: 742 NYSEG 746 Score = 49.7 bits (117), Expect = 1e-05 Identities = 61/238 (25%), Positives = 95/238 (39%), Gaps = 47/238 (19%) Query: 58 TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGA-----------PYLRVDGKTG 106 T + V E PP I ++A PD+G ++ Y+ V ++G Sbjct: 455 TSYMVHVAENNPPGASIAQISASD--PDLGPSGQVSYSIVASDLKPREILSYVSVSAQSG 512 Query: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDIND 163 +F + + D E LR FE+++ Q GSP L ++ V D+ND Sbjct: 513 VVFA-QRAFDHEQLRA-------------FELTLQARDQ-GSPALSANVSLRVLVGDLND 557 Query: 164 NTPNFASPVITL-------AIPENTNIGSLFPIPLASDRDAGPNGVASYE-LQAGPEAQE 215 N P P + +P G L +A D D+G N SY LQA Sbjct: 558 NAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLF 617 Query: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273 GL+ E + + +G+ D R L + V+DGG PP +++A L + D+ Sbjct: 618 SLGLRTGEVRTAR-----ALGDRDAAR---QRLLVAVRDGGQPPLSATATLHLIFADS 667 >gi|9256606 protocadherin beta 12 precursor [Homo sapiens] Length = 795 Score = 333 bits (853), Expect = 7e-91 Identities = 236/704 (33%), Positives = 355/704 (50%), Gaps = 51/704 (7%) Query: 33 GGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKL 92 GG L +L +LL S + + V EE + +G+LA G +V L Sbjct: 4 GGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGL-EVSELSSR 62 Query: 93 EV------GAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146 L++D TGD+ E +DRE L C + +PC+L F+V + + Q Sbjct: 63 GARVVSNDNKECLQLDTNTGDLLLREM-LDREEL--CGSN---EPCVLYFQVLMKNPTQ- 115 Query: 147 GSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYE 206 L+ +++V+DIND++P F + L IPEN+ +G++F + A D D G N V SY Sbjct: 116 ----FLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYT 171 Query: 207 LQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALL 266 + P + ++V D K P+L++ LD E + DGGSPPR+ +AL+ Sbjct: 172 IN--PNSHFHVKIRVNPDNR-KYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALV 228 Query: 267 RVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326 RV V+D NDN+P+FE+ YE ++ ENS +G V+ V A D D G N+E+ YTF A E + Sbjct: 229 RVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDI 288 Query: 327 RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386 R+ +++ +G IT+ P+D E + + + A D G ++ V + V D+NDNAP Sbjct: 289 RKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGG--GLFGKSTVRIQVMDVNDNAPE 346 Query: 387 IEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQAS 446 I + I + I E+ ET V + ++ DRD G+N + C + D+PF L+ Sbjct: 347 ITVSSI--------TSPIPEN-TPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLK--- 394 Query: 447 ETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVF 506 S Y L+T PLD E +Y I I D G P L + +++ V V DVNDNAP F Sbjct: 395 ---SSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAF 451 Query: 507 TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL----EPEPAAKGLFTISPETG 562 TQ+ + ENN P I I+A+D DSG+NA++ YSL +P L +I+ + G Sbjct: 452 TQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNG 511 Query: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV- 621 + SLD E + ++ +V A D GSP+L A V V VLD NDN P + N S Sbjct: 512 HLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAP 571 Query: 622 -MENMP-ALSP---VGMVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSFD 674 E +P A P V V +DGD G+NA QL + G F + G + ++ Sbjct: 572 CTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLS 631 Query: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718 + + + D G PPRSA + + ++D + PY+ P Sbjct: 632 ERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD-GFSQPYLPLP 674 Score = 237 bits (605), Expect = 4e-62 Identities = 178/562 (31%), Positives = 260/562 (46%), Gaps = 37/562 (6%) Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE- 324 + + V D ND++P F E+ ENSP+G + A D D G NA YT + Sbjct: 119 IELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHF 178 Query: 325 -VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDN 383 V R+ +R + + +D E+ L F + A D G+ P+S A V V V D+NDN Sbjct: 179 HVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDN 238 Query: 384 APTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLR 443 +P E + I E+ + V V D D G N+ ++ + Sbjct: 239 SPEFEQAFYEV--------KILENSILGSLVVTVSAWDLDSGTNS--------ELSYTFS 282 Query: 444 QASE----TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDV 499 ASE T ++K + T PLD+E ++ Y+I I A D G L +++++QV+DV Sbjct: 283 HASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGG--LFGKSTVRIQVMDV 340 Query: 500 NDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559 NDNAP T S PEN P V+ D DSG N ++V S+ PE L + Sbjct: 341 NDNAPEITVSSITSPIPENT-PETVVMVFRIRDRDSGDNGKMVCSI-PEDIPFVLKSSVN 398 Query: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619 ++ + LDRE R Y + + D G+P L+ + V V D NDN P F + Y Sbjct: 399 NYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYAL 458 Query: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-------IQNGTGTILSSLS 672 V EN +G ++ D D G NAQV S+ + I G + + S Sbjct: 459 FVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRS 518 Query: 673 FDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP----SNTSHKLLTP 728 D E + F++ A D G P S+ V + VLD NDN+P++ P S +L+ Sbjct: 519 LDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPW 578 Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLH 788 G V++V A D DSG NA L Y + GLF + +H+G + + + R H Sbjct: 579 AAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKH 638 Query: 789 RLVVKVSDRGKPPRYGTALVHL 810 RLVV V D G+PPR TA +H+ Sbjct: 639 RLVVLVKDNGEPPRSATATLHV 660 Score = 40.4 bits (93), Expect = 0.009 Identities = 50/211 (23%), Positives = 85/211 (40%), Gaps = 26/211 (12%) Query: 618 NFSVMENMPALSPVGMVTVIDGDKGENAQVQLS--VEQDNGDFV-IQNGTGTILSSLSFD 674 NF VME + + S VG + G + + + V DN + + + TG +L D Sbjct: 32 NFLVMEELQSGSFVGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLD 91 Query: 675 REQ------QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728 RE+ FQ+ + + ++ + + V D ND++P + Sbjct: 92 REELCGSNEPCVLYFQVLMKNP-----TQFLQIELQVRDINDHSPVFLEKEMLLE--IPE 144 Query: 729 QTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGA-------ITLEKEIE 781 + +G +A+D D G+NA Y+I NP F + + L+K ++ Sbjct: 145 NSPVGAVFLLESAKDLDVGINAVKSYTI---NPNSHFHVKIRVNPDNRKYPELVLDKALD 201 Query: 782 RRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812 ++ D G PPR GTALV + V Sbjct: 202 YEERPELSFILTALDGGSPPRSGTALVRVVV 232 >gi|9256610 protocadherin beta 15 precursor [Homo sapiens] Length = 787 Score = 333 bits (853), Expect = 7e-91 Identities = 237/705 (33%), Positives = 352/705 (49%), Gaps = 51/705 (7%) Query: 32 PGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYK 91 P G+R +L LLLLL + Y V EE + + +LA D G VG L + Sbjct: 3 PAGERFPEQRQVLILLLLLEVTLAGWEPRRYSVMEETERGSFVANLANDLGL-GVGELAE 61 Query: 92 L------EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQ 145 E L++D +TG + E +DRE L C P +PCI+ F+V + ++ Sbjct: 62 RGARVVSEDNEQGLQLDLQTGQLILNE-KLDREKL--CG---PTEPCIMHFQVLLKKPLE 115 Query: 146 NGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASY 205 + ++ V DIND++P F +TL IPE +++G++FP+ A D D G N V +Y Sbjct: 116 -----VFRAELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNY 170 Query: 206 ELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL 265 + P + + D K P+L++ LDRE LT+ DGGSPPR+ + Sbjct: 171 NIS--PNSHFHVSTRTRGDGR-KYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQ 227 Query: 266 LRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV 325 + + VLD NDNAP+F + YE ++ ENSP+G V++V A D D G N EI Y+ + + + Sbjct: 228 ILILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQE 287 Query: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385 + + L +G I + +D E +S+ + A D G S + V V V D+NDN P Sbjct: 288 IDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFP 345 Query: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445 + I + + I E+ + ET VAL ++ DRD GEN + C + DVPF+L+ + Sbjct: 346 ELSISSL--------TSPIPEN-SPETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPS 396 Query: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV 505 E Y L T LD E +Y I I D G P L + S+ V V DVNDNAP Sbjct: 397 VE------NFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPA 450 Query: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL----EPEPAAKGLFTISPET 561 FTQ+ + ENN P I ++A+D DSG+NA++ YSL +P L +I+ + Sbjct: 451 FTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDN 510 Query: 562 GEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV 621 G + SLD E +++E +V A DRG P+L A V V VLD NDN P + N S Sbjct: 511 GHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSA 570 Query: 622 --MENMPALSPVG----MVTVIDGDKGENA--QVQLSVEQDNGDFVIQNGTGTILSSLSF 673 E +P + G V +DGD G+NA QL + G F + G + ++ Sbjct: 571 PCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLL 630 Query: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718 + + + D G PPRSA + + ++D + PY+ P Sbjct: 631 SERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD-GFSQPYLPLP 674 Score = 224 bits (571), Expect = 3e-58 Identities = 215/739 (29%), Positives = 317/739 (42%), Gaps = 81/739 (10%) Query: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235 ++ E T GS F LA+D G +A + E E GLQ+ + + QLI+ Sbjct: 34 SVMEETERGS-FVANLANDLGLGVGELAERGARVVSEDNEQ-GLQL----DLQTGQLILN 87 Query: 236 GNLDRERWDS--------YDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEA 287 LDRE+ + + +K P A L VT D ND++P+F Sbjct: 88 EKLDREKLCGPTEPCIMHFQVLLK-----KPLEVFRAELLVT--DINDHSPEFPEREMTL 140 Query: 288 ELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE--VVRRLLRLDRNTGLITVQGPV 345 ++ E S +G KA D D G+N Y V R R + + + Sbjct: 141 KIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTEL 200 Query: 346 DREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANIS 405 DRE+ + LR ++ A D G+ P+S Q+++ V D NDNAP ++ + V + Sbjct: 201 DREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEF-VQALYEV-------QVP 252 Query: 406 EDVAEETAVALVQVSDRDEGENAAVTCVVAG-----DVPFQLRQASETGSDSKKKYFLQT 460 E+ + V V D D G N ++ + D PF+L S KK Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKK------ 306 Query: 461 TTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNK 520 LD+E + Y ++I A D G LS S+ V+V+DVNDN P + S PEN+ Sbjct: 307 ---LDFETMSSYDLDIEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSP 361 Query: 521 PGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE---IQVKTSLDREQRES 577 EV A D DSG N +++ S++ + F + P + + +LDRE R Sbjct: 362 ETEV-ALFRIRDRDSGENGKMICSIQDDVP----FKLKPSVENFYRLVTEGALDRETRAE 416 Query: 578 YELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 637 Y + + D G+P L+ ++ V V D NDN P F + Y V EN +G V+ Sbjct: 417 YNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSAT 476 Query: 638 DGDKGENAQVQLSVEQDNGDFV-------IQNGTGTILSSLSFDREQQSTYTFQLKAVDG 690 D D G NAQV S+ + I G + + S D E + F++ A D Sbjct: 477 DRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDR 536 Query: 691 GVPPRSAYVGVTINVLDENDNAPYITAP----SNTSHKLLTPQTRLGETVSQVAAEDFDS 746 G P S+ V + VLD NDN+P++ P S +L+ G V++V A D DS Sbjct: 537 GFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDS 596 Query: 747 GVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTA 806 G NA L Y + GLF + +H+G + + + R HRLVV V D G+PPR TA Sbjct: 597 GQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATA 656 Query: 807 LVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVAL 866 L+ LL P P ++ L +A V ++ L Sbjct: 657 --------------TLQVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFL 702 Query: 867 L-IALAVLVRYCRQREAKS 884 + L V VR CR+ A S Sbjct: 703 FSVFLFVAVRLCRRSRAAS 721 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.312 0.132 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 44,954,601 Number of Sequences: 37866 Number of extensions: 2322381 Number of successful extensions: 14880 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 201 Number of HSP's successfully gapped in prelim test: 93 Number of HSP's that attempted gapping in prelim test: 5670 Number of HSP's gapped (non-prelim): 1098 length of query: 1060 length of database: 18,247,518 effective HSP length: 113 effective length of query: 947 effective length of database: 13,968,660 effective search space: 13228321020 effective search space used: 13228321020 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.