Search of human proteins with 27262655

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
         (631 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148833504 interleukin 16 isoform 2 [Homo sapiens]                 1236   0.0  
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]        1236   0.0  
gi|87196343 PDZ domain containing 2 [Homo sapiens]                    208   1e-53
gi|148746189 multiple PDZ domain protein [Homo sapiens]                95   2e-19
gi|45827729 scribble isoform b [Homo sapiens]                          81   3e-15
gi|45827731 scribble isoform a [Homo sapiens]                          81   3e-15
gi|112382257 InaD-like [Homo sapiens]                                  77   5e-14
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    75   1e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    74   4e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    74   4e-13
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    74   4e-13
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    74   4e-13
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    72   1e-12
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...    72   1e-12
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...    72   1e-12
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    72   2e-12
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    72   2e-12
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           72   2e-12
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           72   2e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    71   3e-12
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ...    71   3e-12
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ...    71   3e-12
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      70   5e-12
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      70   5e-12
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       70   5e-12
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]    66   8e-11
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       66   1e-10
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]       66   1e-10
gi|8922944 lin-7 homolog C [Homo sapiens]                              62   1e-09
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    62   2e-09

>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
          Length = 1332

 Score = 1236 bits (3197), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 1    MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 60
            MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL
Sbjct: 702  MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 761

Query: 61   DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 120
            DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA
Sbjct: 762  DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 821

Query: 121  SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 180
            SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG
Sbjct: 822  SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 881

Query: 181  RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 240
            RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL
Sbjct: 882  RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 941

Query: 241  LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 300
            LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS
Sbjct: 942  LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 1001

Query: 301  LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 360
            LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL
Sbjct: 1002 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 1061

Query: 361  TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 420
            TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG
Sbjct: 1062 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 1121

Query: 421  AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 480
            AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI
Sbjct: 1122 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 1181

Query: 481  LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 540
            LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS
Sbjct: 1182 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 1241

Query: 541  AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600
            AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW
Sbjct: 1242 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301

Query: 601  NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631
            NIIKALPDGPVTIVIRRKSLQSKETTAAGDS
Sbjct: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 64/225 (28%), Positives = 113/225 (50%), Gaps = 24/225 (10%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVH--RVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
           +L K +  GLGFS+ GG D     I ++   +F  G A+ +G +Q+G+E+L +NG+S+ G
Sbjct: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277

Query: 472 TTHHDALAILRQAREPRQAVIVTRKLT----------PEAMPDLNSST------DSAASA 515
            TH DAL   +QA++    + V  +LT          P     L+SST       S A  
Sbjct: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337

Query: 516 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLT---INRIFKGAASE 572
           S ++ +S        +  V+L+K  AG+G  +  G  S+   + ++   ++ +  G+ + 
Sbjct: 338 SPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAH 394

Query: 573 QSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
               ++ GDEI+++  + +  LT  E + I+     GPV I++ R
Sbjct: 395 LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 38/107 (35%), Positives = 58/107 (54%), Gaps = 2/107 (1%)

Query: 514 SASAASDVSVESTAEATVCT--VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 571
           S S A  V      +A+V +  V ++  + GLGFS+ GGK S++G   + +  IF G A+
Sbjct: 196 SLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAA 255

Query: 572 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
                +Q GDEIL+L G +M GLT  +A    K    G +T+ +R +
Sbjct: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 1/87 (1%)

Query: 415 LHKEEGAGLGFSLAGGADLEN-KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           L KE G GLG  L      +    I VH + P  +A  +G ++ G+E++ I+   +   T
Sbjct: 358 LQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
            ++   IL         +IV+R   P+
Sbjct: 418 LNEVYTILSHCDPGPVPIIVSRHPDPQ 444


>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
          Length = 631

 Score = 1236 bits (3197), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 1   MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 60
           MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL
Sbjct: 1   MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 60

Query: 61  DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 120
           DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA
Sbjct: 61  DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 120

Query: 121 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 180
           SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG
Sbjct: 121 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 180

Query: 181 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 240
           RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL
Sbjct: 181 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 240

Query: 241 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 300
           LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS
Sbjct: 241 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 300

Query: 301 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 360
           LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL
Sbjct: 301 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 360

Query: 361 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 420
           TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG
Sbjct: 361 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 420

Query: 421 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 480
           AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI
Sbjct: 421 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 480

Query: 481 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 540
           LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS
Sbjct: 481 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 540

Query: 541 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600
           AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW
Sbjct: 541 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600

Query: 601 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631
           NIIKALPDGPVTIVIRRKSLQSKETTAAGDS
Sbjct: 601 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score =  208 bits (530), Expect = 1e-53
 Identities = 177/526 (33%), Positives = 264/526 (50%), Gaps = 60/526 (11%)

Query: 132  SSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKP-LGKHEEGRF-SGLLGR- 188
            S+S  S++QRI SFE   ++   D+   +    P    ++KP +G+   G   SG LG  
Sbjct: 2329 STSFFSVKQRIKSFENLANA---DRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHP 2385

Query: 189  -GAAPTLVPQQPEQVLSSGSPAASEARD--PGVSESPPP-----GRQPNQKTLPPGPDPL 240
              AA  L+ +     LSS S   SEA    P +++SP        RQ   +T   G D  
Sbjct: 2386 GDAAARLLRRS----LSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSE 2441

Query: 241  LRL------LSTQAEESQGPVLKMPS--QRARSFPLTRSQSCETKLL-----DEKTSKLY 287
            L+       + T       PV +  S  +  +  P++RS+  E + L     D+  S+ Y
Sbjct: 2442 LKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDY 2501

Query: 288  SISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGS------AET-- 339
            S     S+ + K+ L     I+  ++P  P  G S        +   GS      AET  
Sbjct: 2502 SAGP--SAVLFKTEL----EITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPS 2555

Query: 340  SALDTGFSL-NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 398
            SA DTG +  +L   R ++  L +      GD   LQS  S +   S   +  LI+E K 
Sbjct: 2556 SASDTGEAAQDLPFRRSWSVNLDQLLVSA-GDQQRLQSVLSSVG--SKSTILTLIQEAKA 2612

Query: 399  LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 458
              E      + +   +L+++EG+GLGFS+AGG D+E K ITVHRVF  G ASQEGT+ +G
Sbjct: 2613 QSENE----EDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRG 2668

Query: 459  NEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAA 518
            + +LS+NG SL G  H + L +L QA+  + A++V +K   +  P       +A      
Sbjct: 2669 DFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLL 2728

Query: 519  SDVSV-------ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 571
            S  ++        S A      V + K SAGLG SL+GGK S+ GD PL I R++KG A+
Sbjct: 2729 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAA 2788

Query: 572  EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
            EQ+  ++ GDEIL + G  + GL  F+AWNI+K++P+GPV ++IR+
Sbjct: 2789 EQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 69/232 (29%), Positives = 112/232 (48%), Gaps = 27/232 (11%)

Query: 410 IHVTILHKEEGAGLGFSLAGGADL--ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
           I +  L+KE+G GLGFS+AGG D       I V  +FPNG A+++G +++G+E+L +NG 
Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643

Query: 468 SLKGTTHHDALAILRQARE-----PRQAVIVTRKLTPEAMP-------DLNSSTDSAASA 515
            +KG T  +A+   +Q R        +  +V+  LTP + P         N +T   ASA
Sbjct: 644 PIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA 703

Query: 516 SAASDVSVESTAEAT-------VCTVTLEK---MSAGLGFSLEGGKGSLHGDKPLTINRI 565
             + + S  S    T       V  VTL K   +  G+G      + S  G   + I+ +
Sbjct: 704 GGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSL 760

Query: 566 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
             G+ ++    +  GD+IL++    ++     +   I+   P GPV +VI R
Sbjct: 761 APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)

Query: 418 EEGAGLGFSLAGGADLENK--VITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 475
           +E  GLG  ++GG   +     I V +V   G A ++G +  G+E+L ING  L G +H 
Sbjct: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398

Query: 476 DALAILRQAREPRQAVIVTR--------KLTPEAMPDLNSSTDSAAS 514
           +A+AILR A    Q V+ ++        +LT +++PDL SS +  +S
Sbjct: 399 EAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 6/165 (3%)

Query: 454 TIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAA 513
           ++++ NE++  NG           L + R  R+     ++      +    +  ST S +
Sbjct: 514 SVEEYNELMVRNGDP-----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568

Query: 514 SASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQ 573
           +    S   +   +  ++  +  EK   GLGFS+ GG+  + G   + +  IF   ++ +
Sbjct: 569 TTQVESPWRLIRPSVISIIGLYKEK-GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627

Query: 574 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
              ++ GDEIL + G  ++GLT  EA +  K +  G   + +R K
Sbjct: 628 DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 1/89 (1%)

Query: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595
           L K S GLG  + GG+GS      + + ++ +G A+ +   +  GDE+L + G  + GL+
Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396

Query: 596 RFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
             EA  I+++   G V +V+  K   +++
Sbjct: 397 HEEAVAILRS-ATGMVQLVVASKENSAED 424


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 65/219 (29%), Positives = 113/219 (51%), Gaps = 7/219 (3%)

Query: 402  ATLKQLDGIHVTILHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGN 459
            A   ++ G+    + K     LG S+AGG  + L +  I +  + P G+A+Q   ++ G+
Sbjct: 1823 ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGD 1882

Query: 460  EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 519
             +++I G S +G TH  A+ +L+ A    +  +V                 S+ S +  +
Sbjct: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLT 1942

Query: 520  DVSV--ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-KGAASEQSET 576
              S+  +        ++TLE+   GLGFS+ GG GS HGD P+ +  +F KGAASE    
Sbjct: 1943 SSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGR- 2001

Query: 577  VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 615
            ++ GD+I+ + G +++G+T  EA  I+K    G VT+++
Sbjct: 2002 LKRGDQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 62/226 (27%), Positives = 98/226 (43%), Gaps = 15/226 (6%)

Query: 413 TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
           TI    +G+GLGF + GG   +   + V  + P G+A Q G +  G+ +L I    L G 
Sbjct: 257 TIELVNDGSGLGFGIIGG---KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGM 313

Query: 473 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS---DVSVESTAEA 529
           +      +LRQ     + +I    +     P     T S++  S      D S +   E+
Sbjct: 314 SSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEES 373

Query: 530 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-----KGAASEQSETVQPGDEIL 584
               V L K   GLG ++ G      GDK L  + IF     K +A E    +Q GD+I+
Sbjct: 374 ETFDVELTKNVQGLGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429

Query: 585 QLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 630
            + GT +QG T  +A  +++      +  ++RR   Q  E  +  D
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSRED 475



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 69/277 (24%), Positives = 125/277 (45%), Gaps = 33/277 (11%)

Query: 329  EDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEE 388
            E+ AA       A D    +N  +LR+ T         D+  +   Q+ Q V   L  +E
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATH--------DEAINVLRQTPQRVRLTLYRDE 1712

Query: 389  LKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGL 448
                 +E +V D  T++         L K+ G GLG S+ G  +  +  + V  +   G+
Sbjct: 1713 AP--YKEEEVCDTLTIE---------LQKKPGKGLGLSIVGKRN--DTGVFVSDIVKGGI 1759

Query: 449  ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 508
            A  +G + +G+++L +NG+ ++  T     A+L+         +    L+    P   SS
Sbjct: 1760 ADADGRLMQGDQILMVNGEDVRNATQEAVAALLK---------VSEGSLSSFTFPLSGSS 1810

Query: 509  TDSAASASAASDVSVESTAEATVCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFK 567
            T  +  +S+  +            TV ++K  +  LG S+ GG GS  GD P+ I  +  
Sbjct: 1811 TSESLESSSKKNALASEIQGLR--TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1868

Query: 568  GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
               + Q++ ++ GD I+ + GT+ +G+T  +A N++K
Sbjct: 1869 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 35/201 (17%)

Query: 400  DEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGN 459
            D AT   + G   TI   +   GLG S+ GG+D     I +H V+  G A ++G +  G+
Sbjct: 1616 DPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGD 1675

Query: 460  EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 519
            ++L +NG  L+  TH +A+ +LRQ              TP+ +  L    D A       
Sbjct: 1676 QILEVNGIDLRKATHDEAINVLRQ--------------TPQRV-RLTLYRDEA------- 1713

Query: 520  DVSVESTAEATVC-TVTLE---KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 575
                    E  VC T+T+E   K   GLG S+ G +     D  + ++ I KG  ++   
Sbjct: 1714 -----PYKEEEVCDTLTIELQKKPGKGLGLSIVGKR----NDTGVFVSDIVKGGIADADG 1764

Query: 576  TVQPGDEILQLGGTAMQGLTR 596
             +  GD+IL + G  ++  T+
Sbjct: 1765 RLMQGDQILMVNGEDVRNATQ 1785



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 72/299 (24%), Positives = 119/299 (39%), Gaps = 49/299 (16%)

Query: 364 KEDDDGDHSSLQSGQSVISLLSSEE----LKKLIEEVKVLD--EATL----KQLDGIH-- 411
           KE+ + D   L S ++   L + EE    L   IEE++     EA L    +++ GI+  
Sbjct: 491 KENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYE 550

Query: 412 VTILHKE---EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 468
           + + H     E +GLG SL            +  V P G     G +  G+E+L +NG +
Sbjct: 551 IVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606

Query: 469 LKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL----------------------- 505
           L G  H D + IL++       V   R + P    +L                       
Sbjct: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666

Query: 506 NSSTDSAASASAASDVSVESTA------EATVCTVTLEKMSAGLGFSLEGGKGSLH-GDK 558
           +S T+    A   +  S E         EA +  + LEK S GLGFS+   +  +     
Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAST 726

Query: 559 PLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
            + I  +  G  +E+   + PGD ++ +    ++  +  EA   +K  P G V I + +
Sbjct: 727 VIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 18/197 (9%)

Query: 410  IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 469
            +H+  L K   +GLG SLAG  D     + +  + PNG A ++G +Q  +E+L ING+ L
Sbjct: 1348 LHMIELEKGH-SGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406

Query: 470  KGTTHHDALAILRQAREPRQAVIVTRK--------LTPEAMPDLNSSTDSAASAS----- 516
             G +H +A +I++ A    + + +  K            A+  L S++++  +       
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466

Query: 517  AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 576
              SD +V+ ++   V  + L K   GLG ++   + +L G   + I  + +   +     
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSG---VIIKSLTEHGVAATDGR 1522

Query: 577  VQPGDEILQLGGTAMQG 593
            ++ GD+IL +    + G
Sbjct: 1523 LKVGDQILAVDDEIVVG 1539



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 55/238 (23%), Positives = 112/238 (47%), Gaps = 34/238 (14%)

Query: 415  LHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 474
            L K++G GLG +++    L   +I    +  +G+A+ +G ++ G+++L+++ + + G   
Sbjct: 1486 LPKDQG-GLGIAISEEDTLSGVIIK--SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542

Query: 475  HDALAILRQAREPRQAVIVTRKLTPEAMPDL---------NSST------------DSAA 513
               +++L+ A+   +  I       +A+P           NSS             +S  
Sbjct: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602

Query: 514  SASAASDVSVESTAEATV-----CTVTLE--KMSAGLGFSLEGGKGSLHGDKPLTINRIF 566
            + S +S  ++ ++  AT      C  T+E  K   GLG S+ GG  +L G   + I+ ++
Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG--AIIIHEVY 1660

Query: 567  KGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
            +  A+ +   +  GD+IL++ G  ++  T  EA N+++  P   V + + R     KE
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ-RVRLTLYRDEAPYKE 1717



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 60/279 (21%), Positives = 102/279 (36%), Gaps = 71/279 (25%)

Query: 394 EEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEG 453
           EE +  D    K + G+ +TI              G   LE   I V  +  +     +G
Sbjct: 371 EESETFDVELTKNVQGLGITIA----------GYIGDKKLEPSGIFVKSITKSSAVEHDG 420

Query: 454 TIQKGNEVLSINGKSLKGTTHHDALAILRQARE-----------PRQAVIVTRK------ 496
            IQ G+++++++G +L+G T+  A+ +LR   +            ++A +++R+      
Sbjct: 421 RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA 480

Query: 497 -LTP----------EAMPDLNSSTDS--------------AASASAASDVSVESTA---- 527
            L+P          E   D  SST +              +A      D   +  A    
Sbjct: 481 DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540

Query: 528 ---------EATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ 578
                    E  V  V+    ++GLG SLE   G         I  +        S  + 
Sbjct: 541 WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHF------IRSVLPEGPVGHSGKLF 594

Query: 579 PGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
            GDE+L++ G  + G    +  NI+K LP     +  RR
Sbjct: 595 SGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRR 633



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 36/147 (24%), Positives = 60/147 (40%), Gaps = 16/147 (10%)

Query: 499  PEAMPDLNSSTDSAASASAASDVSVES--------------TAEATVCTVTLEKMSAGLG 544
            P A  ++ S    ++++  + DV  E               T    +  + LEK  +GLG
Sbjct: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361

Query: 545  FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
             SL G K        + I  I    A+ +   +Q  DE+L++ G  + G +   A +IIK
Sbjct: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419

Query: 605  ALPDGPVTIVIRRKSLQSKETTAAGDS 631
              P     I IR K   ++     G++
Sbjct: 1420 CAPSKVKIIFIRNKDAVNQMAVCPGNA 1446



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 2/86 (2%)

Query: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGL 594
           L+  S GLGFS+ G +    G+  + +  I +G+ + +   ++  D+IL + G A+ Q +
Sbjct: 141 LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200

Query: 595 TRFEAWNIIKALPDGPVTIVIRRKSL 620
           T  +A +I++   D  V +VI R SL
Sbjct: 201 THQQAISILQKAKD-TVQLVIARGSL 225


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%)

Query: 100 NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 159
           +R S  + L  P        A+ E  G   RA+   S ++    S E   S   P     
Sbjct: 443 SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497

Query: 160 RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 213
               QP SG    PL   EE R S   G     R +A T+   +PE   +     +  EA
Sbjct: 498 ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551

Query: 214 RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 272
              G  E      Q  + T+    D LL     + EE Q      +P  R R   L R  
Sbjct: 552 TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606

Query: 273 SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 325
           +   K       K + IS       + +LL         + P  P           +P +
Sbjct: 607 TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657

Query: 326 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 385
              E+    GS +    +        E R   E  +  +ED +G   ++ S  SV  +  
Sbjct: 658 QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709

Query: 386 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 440
            +    LIE  ++ +E        + +TIL +    GLG S+AGG        +++ I +
Sbjct: 710 DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760

Query: 441 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 487
            RV   G A++ G ++ G+++L +NG +L+G  HH+A+  LR A              EP
Sbjct: 761 SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819

Query: 488 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 546
             AV +T  L PE   D  S  +          +  ES        V  L +   GLGFS
Sbjct: 820 ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875

Query: 547 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 588
           + GGKGS     GD  + ++RI +G A+ ++ T+Q GD +L + G
Sbjct: 876 IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%)

Query: 411  HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 465
            HV  L + E  GLGFS+AGG         +  I V R+   G A + GT+Q G+ VLSIN
Sbjct: 861  HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919

Query: 466  GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 516
            G  +    H  A+++L  A  P  A+++ R+    L P  +P  +  T + A+ S     
Sbjct: 920  GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978

Query: 517  ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 564
                     A S ++        V  + L +    LG S+ G  GS H   P  +     
Sbjct: 979  PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036

Query: 565  -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
                 + +G A+     ++ GD IL + G  ++  T  EA + +   P   +++++RR
Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%)

Query: 369  GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 424
            GD     +GQ V      E +  L+     L+ + L + D    G+    + K  G  LG
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112

Query: 425  FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
             S+ GGA        D  ++ I + +V P G A ++G ++ G  +L +N +SL G TH +
Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172

Query: 477  ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 516
            A+ +LR          V   LT        +STD+A   S
Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%)

Query: 514 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 569
           S   A+++ +E +  E    T+T+ + + GLG S+ GGKGS      D+ + I+R+ +  
Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767

Query: 570 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 599
            + ++  V+ GD++L++ G A+QG    EA
Sbjct: 768 PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%)

Query: 100 NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 159
           +R S  + L  P        A+ E  G   RA+   S ++    S E   S   P     
Sbjct: 443 SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497

Query: 160 RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 213
               QP SG    PL   EE R S   G     R +A T+   +PE   +     +  EA
Sbjct: 498 ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551

Query: 214 RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 272
              G  E      Q  + T+    D LL     + EE Q      +P  R R   L R  
Sbjct: 552 TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606

Query: 273 SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 325
           +   K       K + IS       + +LL         + P  P           +P +
Sbjct: 607 TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657

Query: 326 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 385
              E+    GS +    +        E R   E  +  +ED +G   ++ S  SV  +  
Sbjct: 658 QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709

Query: 386 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 440
            +    LIE  ++ +E        + +TIL +    GLG S+AGG        +++ I +
Sbjct: 710 DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760

Query: 441 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 487
            RV   G A++ G ++ G+++L +NG +L+G  HH+A+  LR A              EP
Sbjct: 761 SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819

Query: 488 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 546
             AV +T  L PE   D  S  +          +  ES        V  L +   GLGFS
Sbjct: 820 ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875

Query: 547 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 588
           + GGKGS     GD  + ++RI +G A+ ++ T+Q GD +L + G
Sbjct: 876 IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%)

Query: 411  HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 465
            HV  L + E  GLGFS+AGG         +  I V R+   G A + GT+Q G+ VLSIN
Sbjct: 861  HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919

Query: 466  GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 516
            G  +    H  A+++L  A  P  A+++ R+    L P  +P  +  T + A+ S     
Sbjct: 920  GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978

Query: 517  ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 564
                     A S ++        V  + L +    LG S+ G  GS H   P  +     
Sbjct: 979  PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036

Query: 565  -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
                 + +G A+     ++ GD IL + G  ++  T  EA + +   P   +++++RR
Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%)

Query: 369  GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 424
            GD     +GQ V      E +  L+     L+ + L + D    G+    + K  G  LG
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112

Query: 425  FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
             S+ GGA        D  ++ I + +V P G A ++G ++ G  +L +N +SL G TH +
Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172

Query: 477  ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 516
            A+ +LR          V   LT        +STD+A   S
Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%)

Query: 514 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 569
           S   A+++ +E +  E    T+T+ + + GLG S+ GGKGS      D+ + I+R+ +  
Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767

Query: 570 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 599
            + ++  V+ GD++L++ G A+QG    EA
Sbjct: 768 PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 46/345 (13%)

Query: 277  KLLDEKTSKLYSISSQVSSAVMKS------LLCLPSSISCAQTPCIPKEGASPTSSSNED 330
            +LL+     LY  S Q +SA++K+      L+ + +  +  Q    P    S + SS ED
Sbjct: 1286 ELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIED 1345

Query: 331  SAAN---GSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSE 387
             +      S E  +++ G    L E   +   +++ K+       S  S +  ++  SS 
Sbjct: 1346 QSGTEPISSEEDGSVEVGIK-QLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSY 1404

Query: 388  ELKKL-------IEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITV 440
                         +    +D AT   + G  + I   +  +GLG S+ GG D     I +
Sbjct: 1405 HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVI 1464

Query: 441  HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPE 500
            H V+  G A+++G +  G+++L +NG  L+ ++H +A+  LRQ  +  + V+        
Sbjct: 1465 HEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY------- 1517

Query: 501  AMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKP 559
                               +          +  V L+K +  GLG S+ G +        
Sbjct: 1518 -----------------RDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNG----SG 1556

Query: 560  LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            + I+ I KG A++    +  GD+IL + G  M+  ++     I+K
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 55/215 (25%), Positives = 97/215 (45%), Gaps = 22/215 (10%)

Query: 419 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
           +G+GLGF + GG   +   + V  + P GLA ++G +Q G+ +L I G +++G T     
Sbjct: 254 DGSGLGFGIVGG---KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310

Query: 479 AILRQ---------AREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 529
            +LR          AR+P   + V    TP A   L  +  + AS    SD S+  T   
Sbjct: 311 QVLRNCGNSVRMLVARDPAGDISV----TPPAPAALPVALPTVASKGPGSDSSLFETYNV 366

Query: 530 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKP--LTINRIFKGAASEQSETVQPGDEILQLG 587
            +    + K    LG  + G  G+ H  +   + +  I  G+A+  +  +Q  D+I+ + 
Sbjct: 367 EL----VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422

Query: 588 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 622
           G  +QG    +   +++         ++RRK+  S
Sbjct: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 62/269 (23%), Positives = 121/269 (44%), Gaps = 27/269 (10%)

Query: 340 SALDTGFSLNLSELREYTEG-LTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 398
           S     F  +   L  +T+G +T        ++S++         L +E+   +I+++  
Sbjct: 69  SDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQM-- 126

Query: 399 LDEATLKQLDGIHVTILHKEEGAGLGFSLAG--GADLENKVITVHRVFPNGLASQEGTIQ 456
              A  +Q++ I +    +    GLGFS+      +L    I V  V P  +A ++  ++
Sbjct: 127 ---AQGRQIEYIDI---ERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK 180

Query: 457 KGNEVLSINGKSL-KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
           + +++L+IN   L +  +H  A+A+L+Q     + ++    +           T S+ S+
Sbjct: 181 ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPV----------HTKSSTSS 230

Query: 516 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 575
           S       E+     V  V L    +GLGF + GGK S      + +  I  G  +++  
Sbjct: 231 SLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDG 285

Query: 576 TVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            +Q GD IL++GGT +QG+T  +   +++
Sbjct: 286 RLQTGDHILKIGGTNVQGMTSEQVAQVLR 314



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 29/232 (12%)

Query: 400  DEATLKQLDGIHV--TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQK 457
            DEA  +  + + +    L K+ G GLG S+ G  +     + +  +   G A  +G + +
Sbjct: 1519 DEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQ 1576

Query: 458  GNEVLSINGKSLKGTTHHDALAILRQAREPRQAVI--------VTRKLTPEAMPDLNSST 509
            G+++LS+NG+ ++  +      IL+ A+   Q  I         + + T +       S 
Sbjct: 1577 GDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSA 1636

Query: 510  DSAASASAA---------------SDVSVESTA-EATVCTVTLEK-MSAGLGFSLEGGKG 552
             S+   S A               SD S +++  +    TV + + +S  LG S+ GG+G
Sbjct: 1637 HSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696

Query: 553  SLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            S  GD P+ I  I     + +++ ++ GD I+ + G  + GL+  +  N++K
Sbjct: 1697 SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 10/129 (7%)

Query: 410  IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 469
            +H+  L K++  GLG SLAG  D     I V  + P G A+ +G ++ G+E+L IN + L
Sbjct: 1237 LHIIELEKDKN-GLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295

Query: 470  KGTTHHDALAILRQAREPRQAVIVTRK-------LTPEAMPDLNSSTDSAASASAASDVS 522
             G +H +A AI++ A    + V +  +       +TP  +P  +SS  S    S    +S
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP--SSSPSSIEDQSGTEPIS 1353

Query: 523  VESTAEATV 531
             E      V
Sbjct: 1354 SEEDGSVEV 1362



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 46/196 (23%), Positives = 85/196 (43%), Gaps = 11/196 (5%)

Query: 440 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 499
           +  +   G     G +Q  +E+L +NG  L G +  +A++ L++   P   V   R    
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDD 642

Query: 500 EAMPDLNSSTDSAASASAAS---DVSVESTAEATVCT-------VTLEKMSAGLGFSLEG 549
           EA  D    T+++   +      DV+ E   +  +         V L K   GLGFS+  
Sbjct: 643 EASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD 702

Query: 550 GKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD 608
            +  L   + + + R +     +E+S  + PGD ++ +    +   +  EA  I+KA+P 
Sbjct: 703 YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPP 762

Query: 609 GPVTIVIRRKSLQSKE 624
           G V + I +  ++  E
Sbjct: 763 GLVHLGICKPLVEDNE 778



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 50/254 (19%), Positives = 96/254 (37%), Gaps = 52/254 (20%)

Query: 415  LHKEEGAGLGFSLAGGADL--------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 466
            + +E    LG S+ GG  +        E K I + +V  +  A +   ++ G+++L ++G
Sbjct: 1071 IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSG 1130

Query: 467  KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS---------- 516
              L+  +H +A+  ++ A  P   ++ +   TP  +P++++  +                
Sbjct: 1131 VDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEK 1190

Query: 517  ----------------AASDVSVESTAE----------------ATVCTVTLEKMSAGLG 544
                            A +D S E+  E                  +  + LEK   GLG
Sbjct: 1191 RQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLG 1250

Query: 545  FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
             SL G K        + +  I     +     ++ GDE+L++    + G +   A  IIK
Sbjct: 1251 LSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308

Query: 605  ALPDGPVTIVIRRK 618
              P     + IR +
Sbjct: 1309 TAPSKVKLVFIRNE 1322



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 415 LHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLK 470
           L +++G  LG  + G        E   I V  + P   A   G IQ  +++++++G +++
Sbjct: 368 LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427

Query: 471 GTTHHDALAILRQAREPRQAVIVTRKLTPEAMP 503
           G  +HD + +LR A +     +V RK +    P
Sbjct: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSP 460



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 21/72 (29%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 415  LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
            +++E    LG S+AGG  + L +  + +  +  +G+A++   ++ G+ ++SING+ L G 
Sbjct: 1679 INRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738

Query: 473  THHDALAILRQA 484
            +H D + +L+ A
Sbjct: 1739 SHADVVNLLKNA 1750



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 8/86 (9%)

Query: 534  VTLEKMSAGLGFSLEGGKGSLHGDKPL---TINRIFKGAASEQSETVQPGDEILQLGGTA 590
            + + K  +GLG S+ GGK     D PL    I+ +++  A+ +   +  GD+IL++ G  
Sbjct: 1438 IEISKGRSGLGLSIVGGK-----DTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492

Query: 591  MQGLTRFEAWNIIKALPDGPVTIVIR 616
            ++  +  EA   ++  P     +V R
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYR 1518



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 7/102 (6%)

Query: 517 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 576
           A  D  +   AE    +  L   +  LG  ++   G  +      I+ I  G   +    
Sbjct: 544 ATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHY------ISSIVSGGPVDTLGL 597

Query: 577 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
           +QP DE+L++ G  + G +R EA + +K +P  P T+V  R+
Sbjct: 598 LQPEDELLEVNGMQLYGKSRREAVSFLKEVPP-PFTLVCCRR 638



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 26/137 (18%)

Query: 349 NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD 408
           ++ E R     L E + D + D ++ +     ++L S E   K++E VK           
Sbjct: 645 SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEV--KIVELVK----------- 691

Query: 409 GIHVTILHKEEGAGLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSIN 465
                     +  GLGFS+       D    VI +  +  +G+A + G +  G+ ++S+N
Sbjct: 692 ----------DCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741

Query: 466 GKSLKGTTHHDALAILR 482
              L  T+  +A+ IL+
Sbjct: 742 EYCLDNTSLAEAVEILK 758



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 17/90 (18%), Positives = 49/90 (54%), Gaps = 2/90 (2%)

Query: 540 SAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGLTRFE 598
           + GLGFS+   +    G   + +  +  G+ +++ + ++  D+IL +  T + Q ++  +
Sbjct: 142 TGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201

Query: 599 AWNIIKALPDGPVTIVIRRKSLQSKETTAA 628
           A  +++    G + +++ R+ + +K +T++
Sbjct: 202 AIALLQQ-TTGSLRLIVAREPVHTKSSTSS 230


>gi|223890252 glutamate receptor interacting protein 1 [Homo
           sapiens]
          Length = 1076

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 84/322 (26%), Positives = 140/322 (43%), Gaps = 46/322 (14%)

Query: 305 PSSISCAQTPCIPKE--GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTE 362
           P      +   IP+E  G++      ++    G   +  +D      +S LR+   G   
Sbjct: 33  PDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQ---GGIA 89

Query: 363 AKED--DDGDHSSLQSG--------QSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHV 412
           A+ D  D GD+    +G          +ISLL +   + ++E    L   +++    I  
Sbjct: 90  ARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFR 149

Query: 413 TI---LHKEEGAGLGFSLAGGA-DLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSING 466
           T+   LHKE G   GF + GGA D  NK   + +  V P G A +EGTI+ G+ +LS++G
Sbjct: 150 TVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208

Query: 467 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVEST 526
             L GTTH +A++IL+Q  +   A+++   +         S  DS A+AS    V V  T
Sbjct: 209 IRLLGTTHAEAMSILKQCGQ-EAALLIEYDV---------SVMDSVATASGPLLVEVAKT 258

Query: 527 AEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQL 586
             A++       M                  + + I++I   + +++   +  GD IL +
Sbjct: 259 PGASLGVALTTSMCC--------------NKQVIVIDKIKSASIADRCGALHVGDHILSI 304

Query: 587 GGTAMQGLTRFEAWNIIKALPD 608
            GT+M+  T  EA   +    D
Sbjct: 305 DGTSMEYCTLAEATQFLANTTD 326



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 31/230 (13%)

Query: 405 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 464
           ++  G  V  L K+EG  LG +++GG D + K   V  +   G+A++   +  G+ + ++
Sbjct: 46  EEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLDVGDYIKAV 104

Query: 465 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 524
           NG +L    H + +++L+   E R  + V  +L P                     VSV+
Sbjct: 105 NGINLAKFRHDEIISLLKNVGE-RVVLEVEYELPP---------------------VSVQ 142

Query: 525 -STAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDK----PLTINRIFKGAASEQSETVQP 579
            S+       VTL K     GF + GG    H D+    P+ I  +  G  +++  T++P
Sbjct: 143 GSSVIFRTVEVTLHKEGNTFGFVIRGGA---HDDRNKSRPVVITCVRPGGPADREGTIKP 199

Query: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 629
           GD +L + G  + G T  EA +I+K        ++    S+     TA+G
Sbjct: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 49/244 (20%), Positives = 111/244 (45%), Gaps = 37/244 (15%)

Query: 387 EELKKLIEEVKVLDEATLK----------QLDGIHVTILHKEEGAGLGFSLAGGADLE-N 435
           EE  +L+ +  +  + TL+             G     L K+    LG +++  +  +  
Sbjct: 486 EEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPG 545

Query: 436 KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR 495
             + +  +    +A + GT++ G+++L+I+   L   +  DA+ IL+Q  +     +V  
Sbjct: 546 DPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-----LVKL 600

Query: 496 KLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLH 555
           K+      D ++S +  +S              A + TV L++    LG ++ G +    
Sbjct: 601 KIRK----DEDNSDEQESSG-------------AIIYTVELKRYGGPLGITISGTEEPFD 643

Query: 556 GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 615
              P+ I+ + KG  +E++  +  GD IL +  ++++G    EA ++++ +    VT+ I
Sbjct: 644 ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ-MAGETVTLKI 699

Query: 616 RRKS 619
           ++++
Sbjct: 700 KKQT 703



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 24/181 (13%)

Query: 449 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 508
           A + G +Q G+ V++ING   + +T  +A  +LR +        +T K+T E   D+   
Sbjct: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-------ITSKVTLEIEFDV--- 509

Query: 509 TDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 568
            +S   +S    V +             +K +  LG ++        GD PL I+ I KG
Sbjct: 510 AESVIPSSGTFHVKLP------------KKHNVELGITISSPSSRKPGD-PLVISDIKKG 556

Query: 569 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAA 628
           + + ++ T++ GD++L +    +   +  +A  I++   D  V + IR+    S E  ++
Sbjct: 557 SVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-LVKLKIRKDEDNSDEQESS 615

Query: 629 G 629
           G
Sbjct: 616 G 616



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 10/153 (6%)

Query: 370 DHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG-IHVTILHKEEGAGLGFSLA 428
           D+ S++    ++     E+L KL +  K  D +  ++  G I  T+  K  G  LG +++
Sbjct: 580 DNCSMEDAVQILQ--QCEDLVKL-KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITIS 636

Query: 429 GGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPR 488
           G  +  + +I +  +   GLA + G I  G+ +L+IN  SLKG    +A+ +L+ A E  
Sbjct: 637 GTEEPFDPII-ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-- 693

Query: 489 QAVIVTRKLTPEAMPDLNSSTDSAASASAASDV 521
               VT K+  +      SS      +S  SD+
Sbjct: 694 ---TVTLKIKKQTDAQSASSPKKFPISSHLSDL 723



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)

Query: 387 EELKKLIE-EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP 445
           +E   LIE +V V+D  ++    G  +  + K  GA LG +L        +VI + ++  
Sbjct: 228 QEAALLIEYDVSVMD--SVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKS 285

Query: 446 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAM--P 503
             +A + G +  G+ +LSI+G S++  T  +A   L    +  +  I+    T  A+  P
Sbjct: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGP 345

Query: 504 DLNSSTDSAASASAASDVSVESTAEATV 531
           D  +   S+ S ++ S  S+ S    T+
Sbjct: 346 DHAALVSSSFSPTSMSAYSLSSLNMGTL 373


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 35/223 (15%)

Query: 414 ILHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 469
           I+ +   +GLGFS+AGG D     ++  I + ++ P G A+ +G +   + VL +N   +
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

Query: 470 KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 529
               H  A+  L++A    + V+  R+  PE                             
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRRRQPPPE----------------------------- 222

Query: 530 TVCTVTLEKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLG 587
           T+  V L K   GLGFS+ GG G+ H  GD  + I +I +G A+++   +Q GD +L + 
Sbjct: 223 TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282

Query: 588 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 630
            T +Q +   EA   +K   D     V +  SL   +  A  D
Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPD 325



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 49/235 (20%)

Query: 422 GLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   +    +  I + ++   G A ++G +Q G+ +L++N  +L+   H +A
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294

Query: 478 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE--------STAEA 529
           +A L+   +     +   K     + D+ +  D A++ +A +D  +            E+
Sbjct: 295 VASLKNTSD--MVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVES 352

Query: 530 TVC------------------------------TVTLEKMSAGLGFSLEGGKGSLHGDKP 559
            V                                + L K S GLGF++ GG+      + 
Sbjct: 353 KVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG----EG 408

Query: 560 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIV 614
           + ++ I  G  ++ S  ++ GD IL + G  ++  T  +A   +K      VTIV
Sbjct: 409 IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS-VTIV 462



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           ILHK    GLGF++ GG D E   I V  +   G A   G +++G+ +LS+NG +L+  T
Sbjct: 388 ILHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A A L++A    Q+V +  +  PE
Sbjct: 445 HEQAAAALKRA---GQSVTIVAQYRPE 468


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)

Query: 350  LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 409
            +S++ +Y++      + D+  +SS Q  Q+     SS          K    +  K  D 
Sbjct: 1118 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1175

Query: 410  IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
              V +   +    LG S+ GG +  + +  I V  V P G A  +G I KG+ VL++NG 
Sbjct: 1176 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233

Query: 468  SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 514
            SL+G TH  A+  LR             Q+   ++ V VT + T   + D N+       
Sbjct: 1234 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1290

Query: 515  ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 570
                + V   S   E     V L K S+GLGFS       +        + + ++F G  
Sbjct: 1291 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1350

Query: 571  SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            + +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1351 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)

Query: 415  LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
            L K+   GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G 
Sbjct: 905  LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964

Query: 473  THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 527
            +HH A+ IL+ A E    VI   K     +P       N   +    +S   D +++S++
Sbjct: 965  SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1024

Query: 528  E 528
            +
Sbjct: 1025 K 1025



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 522 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 580
           S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 891 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 950

Query: 581 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 623
           D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 951 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 993



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 416  HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 475
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1698 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754

Query: 476  DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1755 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1789



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 412  VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1598 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1653

Query: 472  TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 525
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1654 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1693

Query: 526  TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 585
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1694 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1742

Query: 586  LGGTAMQGLT 595
            + G + QG+T
Sbjct: 1743 VNGVSTQGMT 1752



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 21/91 (23%), Positives = 40/91 (43%)

Query: 534  VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 593
            V L K    LG S+ GG  +      + +  +    A+E    +  GD +L + G +++G
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237

Query: 594  LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
             T  +A   ++        ++ + +S  SKE
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1268


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)

Query: 350  LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 409
            +S++ +Y++      + D+  +SS Q  Q+     SS          K    +  K  D 
Sbjct: 1309 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1366

Query: 410  IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
              V +   +    LG S+ GG +  + +  I V  V P G A  +G I KG+ VL++NG 
Sbjct: 1367 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1424

Query: 468  SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 514
            SL+G TH  A+  LR             Q+   ++ V VT + T   + D N+       
Sbjct: 1425 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1481

Query: 515  ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 570
                + V   S   E     V L K S+GLGFS       +        + + ++F G  
Sbjct: 1482 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1541

Query: 571  SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            + +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1542 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)

Query: 415  LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
            L K+   GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G 
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155

Query: 473  THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 527
            +HH A+ IL+ A E    VI   K     +P       N   +    +S   D +++S++
Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215

Query: 528  E 528
            +
Sbjct: 1216 K 1216



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 522  SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 580
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 581  DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 623
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 416  HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 475
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1889 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945

Query: 476  DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1946 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1980



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 412  VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1789 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1844

Query: 472  TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 525
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1845 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1884

Query: 526  TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 585
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1885 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1933

Query: 586  LGGTAMQGLT 595
            + G + QG+T
Sbjct: 1934 VNGVSTQGMT 1943



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 21/91 (23%), Positives = 40/91 (43%)

Query: 534  VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 593
            V L K    LG S+ GG  +      + +  +    A+E    +  GD +L + G +++G
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428

Query: 594  LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
             T  +A   ++        ++ + +S  SKE
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1459


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)

Query: 350  LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 409
            +S++ +Y++      + D+  +SS Q  Q+     SS          K    +  K  D 
Sbjct: 1290 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1347

Query: 410  IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
              V +   +    LG S+ GG +  + +  I V  V P G A  +G I KG+ VL++NG 
Sbjct: 1348 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405

Query: 468  SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 514
            SL+G TH  A+  LR             Q+   ++ V VT + T   + D N+       
Sbjct: 1406 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1462

Query: 515  ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 570
                + V   S   E     V L K S+GLGFS       +        + + ++F G  
Sbjct: 1463 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1522

Query: 571  SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            + +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1523 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 47/179 (26%), Positives = 84/179 (46%), Gaps = 22/179 (12%)

Query: 372  SSLQSGQSVISLLSSEELKKL-IEEVKVLDEATLKQLDGIH------------VTILHKE 418
            + L + +SV SL  S E +K   +   + D      LD +H            +T+++ +
Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078

Query: 419  EGA--GLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 474
            + A  GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G +H
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138

Query: 475  HDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTAE 528
            H A+ IL+ A E    VI   K     +P       N   +    +S   D +++S+++
Sbjct: 1139 HAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSK 1197



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 522  SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 580
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 1063 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122

Query: 581  DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 623
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1165



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 416  HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 475
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1870 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926

Query: 476  DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1927 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1961



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 412  VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1770 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1825

Query: 472  TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 525
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1826 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1865

Query: 526  TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 585
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1866 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1914

Query: 586  LGGTAMQGLT 595
            + G + QG+T
Sbjct: 1915 VNGVSTQGMT 1924



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 21/91 (23%), Positives = 40/91 (43%)

Query: 534  VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 593
            V L K    LG S+ GG  +      + +  +    A+E    +  GD +L + G +++G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409

Query: 594  LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
             T  +A   ++        ++ + +S  SKE
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1440


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 27/194 (13%)

Query: 418 EEGAGLGFSLAGGADLE---NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 474
           +EG   GF L GGA  +   ++ + +  V P G A +EG+++ G+ +LS++G  L G +H
Sbjct: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309

Query: 475 HDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTV 534
             ALA LRQ        +     TP          D+ A+AS    V +  T        
Sbjct: 310 ATALATLRQCSHEALFQVEYDVATP----------DTVANASGPLMVEIVKTP------- 352

Query: 535 TLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
                 + LG SL     SL     +TI+RI   +  ++S  + PGD IL + GT+M+  
Sbjct: 353 -----GSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405

Query: 595 TRFEAWNIIKALPD 608
           +  EA  ++ ++ +
Sbjct: 406 SLLEATKLLASISE 419



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 22/196 (11%)

Query: 405 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 464
           ++  GI V  L K+EG+ LG +++GG D + K   V  + P GLA++   +  G+ + S+
Sbjct: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196

Query: 465 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 524
           NG  L    H + + +L+   E R  + V  +L P A P+ N                + 
Sbjct: 197 NGIHLTRLRHDEIITLLKNVGE-RVVLEVEYELPPPA-PENNPRI-------------IS 241

Query: 525 STAEATVCTVTLEKMSAGLGFSLEGG-KGSLHGDKPLTINRIFKGAASEQSETVQPGDEI 583
            T +     V+L K     GF L GG     H  +PL +  +  G  +++  +++ GD +
Sbjct: 242 KTVD-----VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296

Query: 584 LQLGGTAMQGLTRFEA 599
           L + G  + G +   A
Sbjct: 297 LSVDGIPLHGASHATA 312



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 28/229 (12%)

Query: 391 KLIEEVKV-LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLA 449
           K++ EV+  + E+ +      HV  L K+    LG +++  +    + + +  +    +A
Sbjct: 634 KVVLEVEFDVAESVIPSSGTFHVK-LPKKRSVELGITISSASRKRGEPLIISDIKKGSVA 692

Query: 450 SQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSST 509
            + GT++ G+++L+I+   L      DA+ ILRQ  +     +V  K+  +       ++
Sbjct: 693 HRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED-----LVKLKIRKD-----EDNS 742

Query: 510 DSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGA 569
           D   +  A S             TV L++    LG ++ G +       P+ I+ + K  
Sbjct: 743 DELETTGAVS------------YTVELKRYGGPLGITISGTEEPF---DPIVISGLTKRG 787

Query: 570 ASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
            +E++  +  GD IL +   +++G    EA ++++   +  VT+ I+++
Sbjct: 788 LAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGE-TVTLKIKKQ 835



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%)

Query: 421 AGLGFSLAGGADLENKVIT---VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           +G G  L GG      + +   V  + P+  A + G +Q G+ VLSING + +  T  +A
Sbjct: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622

Query: 478 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLE 537
             +LR A    + V             L    D A S   +S          T      +
Sbjct: 623 NQLLRDAALAHKVV-------------LEVEFDVAESVIPSS---------GTFHVKLPK 660

Query: 538 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 597
           K S  LG ++     S    +PL I+ I KG+ + ++ T++PGD++L +    +      
Sbjct: 661 KRSVELGITI--SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718

Query: 598 EAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 629
           +A  I++   D  V + IR+    S E    G
Sbjct: 719 DAVQILRQCED-LVKLKIRKDEDNSDELETTG 749



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 25/92 (27%), Positives = 43/92 (46%)

Query: 395 EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 454
           E  V    T+    G  +  + K  G+ LG SL   +     VIT+ R+ P  +  + G 
Sbjct: 328 EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGA 387

Query: 455 IQKGNEVLSINGKSLKGTTHHDALAILRQARE 486
           +  G+ +LSI+G S++  +  +A  +L    E
Sbjct: 388 LHPGDHILSIDGTSMEHCSLLEATKLLASISE 419


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%)

Query: 410  IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
            I+   L KE+G  LGFS+ GG +       I V  + P G A++EG I +G+ +L ++G 
Sbjct: 926  IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984

Query: 468  SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 521
             L G TH  A+  L    +  + V+  R   P +     S+ DS      A  +      
Sbjct: 985  ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1042

Query: 522  ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 575
               S  S  +     V L+K + GLGFS   +E    S      + I R+F G  +E++ 
Sbjct: 1043 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1102

Query: 576  TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
             +  GD IL + G + +GL   E  ++++  P   VT+++ R
Sbjct: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1143



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%)

Query: 408  DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 462
            DG    +  K+   GLGFS         + L++ ++ + R+FP   A + G I  G+ +L
Sbjct: 1052 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1111

Query: 463  SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 505
            ++NG+S +G    + L +LR A  P++  ++  +  P A+P+L
Sbjct: 1112 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1152



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 531 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 589
           +  VTL++    G GF +  G+ S   D  + I+ I  G  +E+++T++PG +IL L   
Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810

Query: 590 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 620
           +++G T   A  +I+  PD    I+ + K +
Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 841



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%)

Query: 415  LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
            L ++   G GF +  G  +   +  I +  + P G A +  TI+ G ++L++N  SL+G 
Sbjct: 756  LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 815

Query: 473  THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 515
            T + A+ +++ + +  + +I   K      PD           SSTD        S  S 
Sbjct: 816  TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 875

Query: 516  SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 542
            +   D + E    A V                      C  +  ++SAG           
Sbjct: 876  TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 935

Query: 543  --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600
              LGFS+ GG  +      + +  I  G  + +   +  GD +LQ+ G  + GLT  +A 
Sbjct: 936  GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995

Query: 601  NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631
              +         ++ RR    +++  +A DS
Sbjct: 996  QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1026


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1309

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%)

Query: 410  IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
            I+   L KE+G  LGFS+ GG +       I V  + P G A++EG I +G+ +L ++G 
Sbjct: 948  IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 1006

Query: 468  SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 521
             L G TH  A+  L    +  + V+  R   P +     S+ DS      A  +      
Sbjct: 1007 ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1064

Query: 522  ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 575
               S  S  +     V L+K + GLGFS   +E    S      + I R+F G  +E++ 
Sbjct: 1065 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1124

Query: 576  TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
             +  GD IL + G + +GL   E  ++++  P   VT+++ R
Sbjct: 1125 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1165



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%)

Query: 408  DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 462
            DG    +  K+   GLGFS         + L++ ++ + R+FP   A + G I  G+ +L
Sbjct: 1074 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1133

Query: 463  SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 505
            ++NG+S +G    + L +LR A  P++  ++  +  P A+P+L
Sbjct: 1134 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1174



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 531 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 589
           +  VTL++    G GF +  G+ S   D  + I+ I  G  +E+++T++PG +IL L   
Sbjct: 773 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832

Query: 590 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 620
           +++G T   A  +I+  PD    I+ + K +
Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 863



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%)

Query: 415  LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
            L ++   G GF +  G  +   +  I +  + P G A +  TI+ G ++L++N  SL+G 
Sbjct: 778  LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 837

Query: 473  THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 515
            T + A+ +++ + +  + +I   K      PD           SSTD        S  S 
Sbjct: 838  TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 897

Query: 516  SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 542
            +   D + E    A V                      C  +  ++SAG           
Sbjct: 898  TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 957

Query: 543  --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600
              LGFS+ GG  +      + +  I  G  + +   +  GD +LQ+ G  + GLT  +A 
Sbjct: 958  GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 1017

Query: 601  NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631
              +         ++ RR    +++  +A DS
Sbjct: 1018 QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1048


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++ P G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 116 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A    +  ++ RK   E                              V  + L
Sbjct: 176 AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 206

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD+IL +    ++ +
Sbjct: 207 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 266

Query: 595 TRFEAWNIIK 604
              +A   +K
Sbjct: 267 MHEDAVAALK 276



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+   H DA
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 478 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 517
           +A L+        +  +P  A +      P+     +   D+  S S+            
Sbjct: 272 VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 331

Query: 518 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 568
                    A D+  E         + + + S GLGF++ GG+      + + I+ I  G
Sbjct: 332 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 387

Query: 569 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
             ++ S  ++ GD+IL + G  ++  +  +A   +K      VTI+ + K
Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 436



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           ++H+    GLGF++ GG D E   I +  +   G A   G ++KG+++LS+NG  L+  +
Sbjct: 358 VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 414

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A   L+ A    Q V +  +  PE
Sbjct: 415 HEQAAIALKNA---GQTVTIIAQYKPE 438



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 534 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 591
           +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ Q   ++  D IL +    +
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168

Query: 592 QGLTRFEAWNIIKALPDGPVTIVIRRK 618
           + +T   A   +K         V+RRK
Sbjct: 169 REVTHSAAVEALKEAGSIVRLYVMRRK 195


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++ P G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 70  SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A    +  ++ RK   E                              V  + L
Sbjct: 130 AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 160

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD+IL +    ++ +
Sbjct: 161 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 220

Query: 595 TRFEAWNIIK 604
              +A   +K
Sbjct: 221 MHEDAVAALK 230



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+   H DA
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225

Query: 478 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 517
           +A L+        +  +P  A +      P+     +   D+  S S+            
Sbjct: 226 VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 285

Query: 518 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 568
                    A D+  E         + + + S GLGF++ GG+      + + I+ I  G
Sbjct: 286 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 341

Query: 569 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
             ++ S  ++ GD+IL + G  ++  +  +A   +K      VTI+ + K
Sbjct: 342 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 390



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           ++H+    GLGF++ GG D E   I +  +   G A   G ++KG+++LS+NG  L+  +
Sbjct: 312 VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A   L+ A    Q V +  +  PE
Sbjct: 369 HEQAAIALKNA---GQTVTIIAQYKPE 392



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 534 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 591
           +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ Q   ++  D IL +    +
Sbjct: 63  ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122

Query: 592 QGLTRFEAWNIIKALPDGPVTIVIRRK 618
           + +T   A   +K         V+RRK
Sbjct: 123 REVTHSAAVEALKEAGSIVRLYVMRRK 149


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++   G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A    +  +  RK   E + ++                              L
Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD++L +    ++ +
Sbjct: 323 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382

Query: 595 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 630
           T  EA   +K   D     V +  S+   +  A  D
Sbjct: 383 THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+  TH +A
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 478 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 514
           +  L+   +     +  +   P +M        PD+ +S+                + AS
Sbjct: 388 VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443

Query: 515 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 570
            +  S VS     +  +      V L + S GLGF++ GG+      + + I+ I  G  
Sbjct: 444 PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499

Query: 571 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           ++ S  ++ GD I+ +    ++  +  +A   +K
Sbjct: 500 ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           +LH+    GLGF++ GG D E   I +  +   G A   G ++KG+ ++S+N   L+  +
Sbjct: 468 VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A A L+ A    QAV +  +  PE
Sbjct: 525 HEQAAAALKNA---GQAVTIVAQYRPE 548



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%)

Query: 487 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 546
           P +  ++   +     P +  +TDS  + +  +    +   E     +TLE+ ++GLGFS
Sbjct: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237

Query: 547 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           + GG  + H   D  + I +I  G A+ Q   ++  D IL++    ++ +T  +A   +K
Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297

Query: 605 ALPDGPVTIVIRRKSLQSK 623
                    V RRK +  K
Sbjct: 298 EAGSIVRLYVKRRKPVSEK 316


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++   G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A    +  +  RK   E + ++                              L
Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD++L +    ++ +
Sbjct: 323 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382

Query: 595 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 630
           T  EA   +K   D     V +  S+   +  A  D
Sbjct: 383 THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+  TH +A
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 478 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 514
           +  L+   +     +  +   P +M        PD+ +S+                + AS
Sbjct: 388 VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443

Query: 515 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 570
            +  S VS     +  +      V L + S GLGF++ GG+      + + I+ I  G  
Sbjct: 444 PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499

Query: 571 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           ++ S  ++ GD I+ +    ++  +  +A   +K
Sbjct: 500 ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           +LH+    GLGF++ GG D E   I +  +   G A   G ++KG+ ++S+N   L+  +
Sbjct: 468 VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A A L+ A    QAV +  +  PE
Sbjct: 525 HEQAAAALKNA---GQAVTIVAQYRPE 548



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%)

Query: 487 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 546
           P +  ++   +     P +  +TDS  + +  +    +   E     +TLE+ ++GLGFS
Sbjct: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237

Query: 547 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           + GG  + H   D  + I +I  G A+ Q   ++  D IL++    ++ +T  +A   +K
Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297

Query: 605 ALPDGPVTIVIRRKSLQSK 623
                    V RRK +  K
Sbjct: 298 EAGSIVRLYVKRRKPVSEK 316


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 59/213 (27%), Positives = 93/213 (43%), Gaps = 28/213 (13%)

Query: 409  GIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 468
            GI VT+L  + G        G        I V  V P G A  +G I KG+ VL++NG S
Sbjct: 1379 GISVTVLFDKGGVNTSVRHGG--------IYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1430

Query: 469  LKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
            L+G TH  A+  LR             Q+   ++ V VT + T   + D N+        
Sbjct: 1431 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEKV 1487

Query: 516  SAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAAS 571
               + V   S   E     V L K S+GLGFS       +        + + ++F G  +
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547

Query: 572  EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
             +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)

Query: 415  LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 472
            L K+   GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G 
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155

Query: 473  THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 527
            +HH A+ IL+ A E    VI   K     +P       N   +    +S   D +++S++
Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215

Query: 528  E 528
            +
Sbjct: 1216 K 1216



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 522  SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 580
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 581  DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 623
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 416  HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 475
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1894 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950

Query: 476  DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1951 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1985



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 412  VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1794 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1849

Query: 472  TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 525
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1850 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1889

Query: 526  TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 585
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1890 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1938

Query: 586  LGGTAMQGLT 595
            + G + QG+T
Sbjct: 1939 VNGVSTQGMT 1948


>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
           [Homo sapiens]
          Length = 1104

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)

Query: 438 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 497
           I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469

Query: 498 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 556
               +P +L    D  A       +S+E++ + T      +  SAGLG SL+G K    G
Sbjct: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522

Query: 557 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 609
            D  + I  I  G A+ +   ++  D+++ + G ++ G +  EA   ++          G
Sbjct: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582

Query: 610 PVTIVIRRKSLQSKETTA 627
            + +VI R+  +  E  A
Sbjct: 583 MIQLVILRRPERPMEDPA 600



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 476 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 535
           DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385

Query: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595
           L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 596 RFEAWNIIKALPDG-PVTIVIRRK 618
           + E   ++++   G   ++VI R+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469


>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
           [Homo sapiens]
          Length = 1136

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)

Query: 438 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 497
           I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469

Query: 498 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 556
               +P +L    D  A       +S+E++ + T      +  SAGLG SL+G K    G
Sbjct: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522

Query: 557 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 609
            D  + I  I  G A+ +   ++  D+++ + G ++ G +  EA   ++          G
Sbjct: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582

Query: 610 PVTIVIRRKSLQSKETTA 627
            + +VI R+  +  E  A
Sbjct: 583 MIQLVILRRPERPMEDPA 600



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 476 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 535
           DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385

Query: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595
           L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 596 RFEAWNIIKALPDG-PVTIVIRRK 618
           + E   ++++   G   ++VI R+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++ P G A+++G ++  + +L +N   +   +H  
Sbjct: 55  SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 114

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A        + R       P L                        TV  + L
Sbjct: 115 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 145

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I  G A+++   +Q GD +L +   +++ +
Sbjct: 146 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205

Query: 595 TRFEAWNIIK 604
           T  EA  I+K
Sbjct: 206 THEEAVAILK 215



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 56/239 (23%), Positives = 98/239 (41%), Gaps = 60/239 (25%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+ +L +N  SL+  TH +A
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210

Query: 478 LAILRQARE----------------PRQAVIVTRKLTP-----------------EAMPD 504
           +AIL+   E                P     +T   +P                  ++P 
Sbjct: 211 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP 270

Query: 505 L-------------------NSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGF 545
           +                   + S  S A+   +  +    + E     V L K S GLGF
Sbjct: 271 ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF 330

Query: 546 SLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           ++ GG+      + + ++ I  G  ++ S  +Q GD+IL + G  ++G +  +A   +K
Sbjct: 331 NIVGGEDG----EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           +LHK    GLGF++ GG D E   I V  +   G A   G +Q+G+++LS+NG  L+G +
Sbjct: 320 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A A L+ A    Q V +  +  PE
Sbjct: 377 HEQAAAALKGA---GQTVTIIAQYQPE 400



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)

Query: 534 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 591
           +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ +   ++  D IL++    +
Sbjct: 48  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107

Query: 592 QGLTRFEAWNIIKALPDGPVTIVIRRK 618
             ++  +A   +K      V + +RR+
Sbjct: 108 SEVSHSKAVEALKE-AGSIVRLYVRRR 133


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++ P G A+++G ++  + +L +N   +   +H  
Sbjct: 211 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 270

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A        + R       P L                        TV  + L
Sbjct: 271 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 301

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I  G A+++   +Q GD +L +   +++ +
Sbjct: 302 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 361

Query: 595 TRFEAWNIIK 604
           T  EA  I+K
Sbjct: 362 THEEAVAILK 371



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           +LHK    GLGF++ GG D E   I V  +   G A   G +Q+G+++LS+NG  L+G +
Sbjct: 528 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A A L+ A    Q V +  +  PE
Sbjct: 585 HEQAAAALKGA---GQTVTIIAQYQPE 608



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+ +L +N  SL+  TH +A
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366

Query: 478 LAILRQARE 486
           +AIL+   E
Sbjct: 367 VAILKNTSE 375



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)

Query: 534 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 591
           +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ +   ++  D IL++    +
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263

Query: 592 QGLTRFEAWNIIKALPDGPVTIVIRRK 618
             ++  +A   +K      V + +RR+
Sbjct: 264 SEVSHSKAVEALKE-AGSIVRLYVRRR 289



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%)

Query: 508 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 567
           S  S A+   +  +    + E     V L K S GLGF++ GG+      + + ++ I  
Sbjct: 501 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 556

Query: 568 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           G  ++ S  +Q GD+IL + G  ++G +  +A   +K
Sbjct: 557 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 421 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 476
           +GLGFS+AGG D     ++  I + ++ P G A+++G ++  + +L +N   +   +H  
Sbjct: 106 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 165

Query: 477 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 536
           A+  L++A        + R       P L                        TV  + L
Sbjct: 166 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 196

Query: 537 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
            K   GLGFS+ GG G+ H  GD  + + +I  G A+++   +Q GD +L +   +++ +
Sbjct: 197 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 256

Query: 595 TRFEAWNIIK 604
           T  EA  I+K
Sbjct: 257 THEEAVAILK 266



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 414 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
           +LHK    GLGF++ GG D E   I V  +   G A   G +Q+G+++LS+NG  L+G +
Sbjct: 423 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479

Query: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
           H  A A L+ A    Q V +  +  PE
Sbjct: 480 HEQAAAALKGA---GQTVTIIAQYQPE 503



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%)

Query: 422 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
           GLGFS+AGG   ++      I V ++   G A ++G +Q G+ +L +N  SL+  TH +A
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261

Query: 478 LAILRQARE 486
           +AIL+   E
Sbjct: 262 VAILKNTSE 270



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)

Query: 534 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 591
           +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ +   ++  D IL++    +
Sbjct: 99  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158

Query: 592 QGLTRFEAWNIIKALPDGPVTIVIRRK 618
             ++  +A   +K      V + +RR+
Sbjct: 159 SEVSHSKAVEALKE-AGSIVRLYVRRR 184



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%)

Query: 508 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 567
           S  S A+   +  +    + E     V L K S GLGF++ GG+      + + ++ I  
Sbjct: 396 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 451

Query: 568 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
           G  ++ S  +Q GD+IL + G  ++G +  +A   +K
Sbjct: 452 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 57/242 (23%), Positives = 110/242 (45%), Gaps = 25/242 (10%)

Query: 409 GIHVTILHKEEGAGLGFSLA------GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 462
           G  + I  K+   GLGFS+       GG+      I V  + P G A Q+G ++ G+ ++
Sbjct: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGS----APIYVKNILPRGAAIQDGRLKAGDRLI 512

Query: 463 SINGKSLKGTTHHDALAILRQAR-EPRQAVIVTRKLTPEAMPDLNS--STDSAASASAAS 519
            +NG  L G +  + +++LR  + E   +++V R+       +LN+  S       + A 
Sbjct: 513 EVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAE 572

Query: 520 DVSVESTAEATVCTVTLE-----KMSAGLGFSLEGGKG-SLHGDKPLTINRIFKGAASEQ 573
           D  +  T + T   +T E       SAGLG S++G +    H D  + +  I  G A+ +
Sbjct: 573 DEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASK 632

Query: 574 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------GPVTIVIRRKSLQSKETTA 627
              ++  D+++ + G ++ G T  +A   ++          G + +++ R+  +  E  +
Sbjct: 633 DGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692

Query: 628 AG 629
            G
Sbjct: 693 PG 694



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 31/99 (31%), Positives = 52/99 (52%), Gaps = 8/99 (8%)

Query: 394 EEVKVLDEATLKQLDGIHVTI-----LHKEEGAGLGFSLAGGADLENKV---ITVHRVFP 445
           +E K  DE  +   DG    +     L+    AGLG S+ G    EN     I V  +  
Sbjct: 567 KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIIN 626

Query: 446 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 484
            G AS++G ++  ++++++NG+SL G T+ DA+  LR++
Sbjct: 627 GGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 58/218 (26%), Positives = 104/218 (47%), Gaps = 18/218 (8%)

Query: 412 VTILHKEEGAGLGFSLAGGA-----DLENKVITVHRVFPNGLASQEGTIQKGNEVLSING 466
           V  + K+ G  LG ++AGGA     DL   VI+V    P G+ S++G I+ G+ +L+++G
Sbjct: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE---PGGVISRDGRIKTGDILLNVDG 563

Query: 467 KSLKGTTHHDALAILRQAREPRQA-VIVTRKLTPEAMPDLNSSTDSAASASAASDVSVES 525
             L   +  +A+A+L++         +  ++  P+      ++ DS  + +  SD S   
Sbjct: 564 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSW 623

Query: 526 TA--EATVCT-----VTLEKMSAG-LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETV 577
               E   C      + L + +AG LGF + GG    +G+KP  I  I +G  +     +
Sbjct: 624 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683

Query: 578 QPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 615
           + GD +L + G +  G+       ++K L  G +T+ I
Sbjct: 684 RCGDILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 720



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 49/225 (21%), Positives = 95/225 (42%), Gaps = 11/225 (4%)

Query: 408 DGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
           D  HV +        LG  L    D     + +  V   G+A + G +++ + VL+ING 
Sbjct: 378 DSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDRVLAINGH 435

Query: 468 SLKGTTHHDALAILRQAREPRQAVIVTRKL---TPEAMPDLNSSTDSAASASAASDVSVE 524
            L+  +   A A L QA E R  ++V+R++   +P+   +   +++ + S       +  
Sbjct: 436 DLRYGSPESA-AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP 494

Query: 525 STAEATVC----TVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQP 579
                T+      V ++K     LG ++ GG      D P+ +  +  G    +   ++ 
Sbjct: 495 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKT 554

Query: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
           GD +L + G  +  ++R EA  ++K      V   +  K  + +E
Sbjct: 555 GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 17/72 (23%), Positives = 37/72 (51%)

Query: 412 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
           + I   +    L   L GG++     I +  ++ +G+ +++G +  G+ +L +NG  +  
Sbjct: 275 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334

Query: 472 TTHHDALAILRQ 483
             H+ A+ +LRQ
Sbjct: 335 VPHNYAVRLLRQ 346


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 58/218 (26%), Positives = 104/218 (47%), Gaps = 18/218 (8%)

Query: 412 VTILHKEEGAGLGFSLAGGA-----DLENKVITVHRVFPNGLASQEGTIQKGNEVLSING 466
           V  + K+ G  LG ++AGGA     DL   VI+V    P G+ S++G I+ G+ +L+++G
Sbjct: 411 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE---PGGVISRDGRIKTGDILLNVDG 467

Query: 467 KSLKGTTHHDALAILRQAREPRQA-VIVTRKLTPEAMPDLNSSTDSAASASAASDVSVES 525
             L   +  +A+A+L++         +  ++  P+      ++ DS  + +  SD S   
Sbjct: 468 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSW 527

Query: 526 TA--EATVCT-----VTLEKMSAG-LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETV 577
               E   C      + L + +AG LGF + GG    +G+KP  I  I +G  +     +
Sbjct: 528 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 587

Query: 578 QPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 615
           + GD +L + G +  G+       ++K L  G +T+ I
Sbjct: 588 RCGDILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 624



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 49/225 (21%), Positives = 95/225 (42%), Gaps = 11/225 (4%)

Query: 408 DGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
           D  HV +        LG  L    D     + +  V   G+A + G +++ + VL+ING 
Sbjct: 282 DSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDRVLAINGH 339

Query: 468 SLKGTTHHDALAILRQAREPRQAVIVTRKL---TPEAMPDLNSSTDSAASASAASDVSVE 524
            L+  +   A A L QA E R  ++V+R++   +P+   +   +++ + S       +  
Sbjct: 340 DLRYGSPESA-AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP 398

Query: 525 STAEATVC----TVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQP 579
                T+      V ++K     LG ++ GG      D P+ +  +  G    +   ++ 
Sbjct: 399 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKT 458

Query: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
           GD +L + G  +  ++R EA  ++K      V   +  K  + +E
Sbjct: 459 GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 503



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 17/72 (23%), Positives = 37/72 (51%)

Query: 412 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
           + I   +    L   L GG++     I +  ++ +G+ +++G +  G+ +L +NG  +  
Sbjct: 179 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 238

Query: 472 TTHHDALAILRQ 483
             H+ A+ +LRQ
Sbjct: 239 VPHNYAVRLLRQ 250


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 30/94 (31%), Positives = 59/94 (62%), Gaps = 4/94 (4%)

Query: 422 GLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAIL 481
           GLGF++ GG + +N  I + R+ P G+A + G +++G+++LS+NG S++G  H  A+ +L
Sbjct: 102 GLGFNIMGGKE-QNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELL 160

Query: 482 RQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 515
           + A+   + V+   + TP+ + ++ S  +   SA
Sbjct: 161 KAAQGKVKLVV---RYTPKVLEEMESRFEKMRSA 191



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 35/115 (30%), Positives = 66/115 (57%), Gaps = 6/115 (5%)

Query: 504 DLNSSTDSAASASAASDVSVESTAE--ATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLT 561
           D++SS +  A+A+A + V+  + +E  +    V L K   GLGF++ GGK     + P+ 
Sbjct: 62  DISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQ---NSPIY 118

Query: 562 INRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIR 616
           I+RI  G  +++   ++ GD++L + G +++G    +A  ++KA   G V +V+R
Sbjct: 119 ISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKA-AQGKVKLVVR 172


>gi|218505835 membrane-associated guanylate kinase-related  3
           isoform 1 [Homo sapiens]
          Length = 1481

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 50/209 (23%), Positives = 96/209 (45%), Gaps = 13/209 (6%)

Query: 415 LHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 474
           L K+E +G GF + GG D  ++ I +  + P G A ++G ++  +E++ I+G  +KG +H
Sbjct: 729 LRKQE-SGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786

Query: 475 HDALAILRQAREPRQAVIVTRK--LTPEAMPDLNS-----STDSAASASAASDVSVESTA 527
              L ++  A      ++  R+     E  P+ +S     ST + +     ++V      
Sbjct: 787 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAP 846

Query: 528 EATVCTVTLEKMSAGLGFSLEGGKGS-LHGDKPLTINRIFKGAASEQSETVQPGDEILQL 586
           +     V   K + G GF +   K     G  P  I R+ +G+ +++   ++ GD I  +
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906

Query: 587 GGTAMQGLTRFEAWNIIKALPDGPVTIVI 615
            G   Q +      NI++ + D  VT+ +
Sbjct: 907 NG---QSIVELSHDNIVQLIKDAGVTVTL 932



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 26/77 (33%), Positives = 43/77 (55%), Gaps = 1/77 (1%)

Query: 406 QLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSIN 465
           QL G+ V    K+   G GF++ GG D  ++ + V  V  +G A+Q+G I  G+ ++ IN
Sbjct: 403 QLKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDIN 461

Query: 466 GKSLKGTTHHDALAILR 482
           G  + G TH D + + +
Sbjct: 462 GNCVLGHTHADVVQMFQ 478



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 51/241 (21%), Positives = 92/241 (38%), Gaps = 52/241 (21%)

Query: 414  ILHKEEGAGLGFSLAGGADLENKVITVH---RVFPNGLASQEGTIQKGNEVLSINGKSLK 470
            +L ++E  G GF +    +     +  H   RV     A + G ++ G+ + ++NG+S+ 
Sbjct: 853  VLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIV 912

Query: 471  GTTHHDALAILRQA---------------------REPRQAVIVTRKLTPEAMPDLNSST 509
              +H + + +++ A                        RQ+  +  +   ++  +     
Sbjct: 913  ELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGD 972

Query: 510  DSAASASAASDVSVE--------------STAEATVC-----------TVTLEKMSAGLG 544
             SA       DVS                 TA  +V             V LE+   G G
Sbjct: 973  RSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFG 1032

Query: 545  FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 604
            FSL GGK    G   L I R+ +   + +   +  GD+I+++ G   QG+T   A  +I+
Sbjct: 1033 FSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089

Query: 605  A 605
            A
Sbjct: 1090 A 1090



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 20/83 (24%), Positives = 39/83 (46%), Gaps = 3/83 (3%)

Query: 525 STAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEIL 584
           S  +  +   +L+K + G GF++ GG      D+ L +  + K   + Q   + PGD I+
Sbjct: 402 SQLKGVLVRASLKKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIV 458

Query: 585 QLGGTAMQGLTRFEAWNIIKALP 607
            + G  + G T  +   + + +P
Sbjct: 459 DINGNCVLGHTHADVVQMFQLVP 481



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 4/86 (4%)

Query: 534 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 593
           V L K  +G GF + GG G    D+ + I  I    A+E+   ++  DE++ + G  ++G
Sbjct: 727 VFLRKQESGFGFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783

Query: 594 LTRFEAWNII-KALPDGPVTIVIRRK 618
            +  +  +++  A  +G V + +RRK
Sbjct: 784 KSHKQVLDLMTTAARNGHVLLTVRRK 809



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 13/30 (43%), Positives = 20/30 (66%)

Query: 458 GNEVLSINGKSLKGTTHHDALAILRQAREP 487
           G+ +L +NG  + G T+ D LA++R  REP
Sbjct: 68  GDVLLEVNGTPVSGLTNRDTLAVIRHFREP 97


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,276,627
Number of Sequences: 37866
Number of extensions: 1411854
Number of successful extensions: 8463
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 539
Number of HSP's that attempted gapping in prelim test: 6927
Number of HSP's gapped (non-prelim): 1824
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.