Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 26665869

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|26665869 WD repeat domain 51B [Homo sapiens]
         (478 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|26665869 WD repeat domain 51B [Homo sapiens]                       977   0.0  
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            424   e-119
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            424   e-118
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            384   e-106
gi|32189425 WD repeat domain 69 [Homo sapiens]                        159   4e-39
gi|23199987 WD repeat domain 5B [Homo sapiens]                        150   2e-36
gi|16554629 WD repeat domain 5 [Homo sapiens]                         149   4e-36
gi|16554627 WD repeat domain 5 [Homo sapiens]                         149   4e-36
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      143   4e-34
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   142   5e-34
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    139   6e-33
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    136   4e-32
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   134   2e-31
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   131   1e-30
gi|113865883 WD repeat domain 38 [Homo sapiens]                       130   3e-30
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         129   6e-30
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         129   6e-30
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         129   6e-30
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]           129   6e-30
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           129   6e-30
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   125   8e-29
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    125   8e-29
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    125   8e-29
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    125   8e-29
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    117   3e-26
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]         116   5e-26
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]         116   5e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   114   3e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   114   3e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   114   3e-25

>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  977 bits (2526), Expect = 0.0
 Identities = 478/478 (100%), Positives = 478/478 (100%)

Query: 1   MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60
           MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK
Sbjct: 1   MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60

Query: 61  DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
           DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA
Sbjct: 61  DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120

Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
           SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN
Sbjct: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180

Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG 240
           NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG
Sbjct: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG 240

Query: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN
Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300

Query: 301 FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP 360
           FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP
Sbjct: 301 FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP 360

Query: 361 VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES 420
           VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES
Sbjct: 361 VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES 420

Query: 421 QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS 478
           QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS
Sbjct: 421 QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS 478


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  424 bits (1090), Expect = e-119
 Identities = 199/334 (59%), Positives = 258/334 (77%), Gaps = 12/334 (3%)

Query: 2   ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61
           A   EDP LER+FKGH+ A+T +D S N KQLA+ S D+ LM+W+ KP +RAYR+ GHKD
Sbjct: 3   APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62

Query: 62  VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
            VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F+AHTA VRSV F +DGQ   TAS
Sbjct: 63  AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
           +DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRLIVS S+DKT+K+WD ++++CV++
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
           + +  GF  +VDF+PSGTCIA+AG D TVKVWDVR ++LLQHYQ+HS  VN +SFHPSGN
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242

Query: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301
           YLITASSD TLKILDL+EGRL+YTL GH GP  TV+FS+ GE FASGG+D QV++W++NF
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302

Query: 302 DELHCKGLTK------------RNLKRLHFDSPP 323
           D +    +TK             NL  + F  PP
Sbjct: 303 DIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPP 336



 Score =  197 bits (500), Expect = 2e-50
 Identities = 135/418 (32%), Positives = 192/418 (45%), Gaps = 38/418 (9%)

Query: 56  YVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
           + GH+D VT V FS +   LAS S D  + +W    + +   F  H   V  V+FS  G 
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
            LA+ S DK++++W    +        HT  VR   F  DG+  V+ S+DKT+K+W T  
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
           ++ + + S  + +     F+P G  I SA  D+TVK+WD    + +  Y  H G V  + 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVL 295
           FHPSG  +  A  D T+K+ D+   RL+   Q H+  V  +SF   G    +  +D+ + 
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254

Query: 296 LWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPH-----PHEEKVETVEINPKLE 350
           +            +  R L  LH    P     + RT         +E+V   + N    
Sbjct: 255 ILDL---------MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN---- 301

Query: 351 VIDLQISTPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKT 410
                       DI+     T       TL             P +  P  +P    +  
Sbjct: 302 -----------FDIVDHGEVTKVPRPPATLASSMGNL------PEVDFP--VPPGRGRSV 342

Query: 411 EDMSDLPCESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQ 468
           E +   P E   S+P  +T  LEHI+ QL+VLTQTVSILEQRLTLTEDKLK CLENQQ
Sbjct: 343 ESVQSQPQEPV-SVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQ 399


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  424 bits (1089), Expect = e-118
 Identities = 194/310 (62%), Positives = 252/310 (81%)

Query: 2   ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61
           A   EDP LER+FKGH+ A+T +D S N KQLA+ S D+ LM+W+ KP +RAYR+ GHKD
Sbjct: 3   APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62

Query: 62  VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
            VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F+AHTA VRSV F +DGQ   TAS
Sbjct: 63  AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
           +DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRLIVS S+DKT+K+WD ++++CV++
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
           + +  GF  +VDF+PSGTCIA+AG D TVKVWDVR ++LLQHYQ+HS  VN +SFHPSGN
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242

Query: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301
           YLITASSD TLKILDL+EGRL+YTL GH GP  TV+FS+ GE FASGG+D QV++W++NF
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302

Query: 302 DELHCKGLTK 311
           D +    +TK
Sbjct: 303 DIVDHGEVTK 312



 Score =  140 bits (352), Expect = 3e-33
 Identities = 120/371 (32%), Positives = 154/371 (41%), Gaps = 34/371 (9%)

Query: 98  FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
           FK H   V  VDFS + + LA+ S D  + VW M  Q   Y    H   V C  FSP G 
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
           L+ S S DKT++IW    K     F         V F   G    +A  D+TVKVW    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
            K L     H   V C  F P G  +++AS D T+K+ D      +++   H G V  V 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 278 FSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHE 337
           F   G   A+ G D  V +W            T R L+        H   +   + HP  
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVR---------THRLLQHYQL----HSAAVNGLSFHPSG 241

Query: 338 EKVETVEINPKLEVIDLQISTPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLM 397
             + T   +  L+++DL +    +  +       TT    RT    GE    YF +    
Sbjct: 242 NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRT----GE----YFASGG-- 290

Query: 398 SPECLPTTTKKKTEDMSDLPCESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTE 457
           S E       K   D+ D    ++   P A    L   M  L     TVSILEQRLTLTE
Sbjct: 291 SDE--QVMVWKSNFDIVDHGEVTKVPRPPAT---LASSMGNL-----TVSILEQRLTLTE 340

Query: 458 DKLKDCLENQQ 468
           DKLK CLENQQ
Sbjct: 341 DKLKQCLENQQ 351


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  384 bits (985), Expect = e-106
 Identities = 178/297 (59%), Positives = 232/297 (78%), Gaps = 12/297 (4%)

Query: 39  DTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEF 98
           D+ LM+W+ KP +RAYR+ GHKD VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 99  KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
           +AHTA VRSV F +DGQ   TAS+DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRL
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
           IVS S+DKT+K+WD ++++CV+++ +  GF  +VDF+PSGTCIA+AG D TVKVWDVR +
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181

Query: 219 KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSF 278
           +LLQHYQ+HS  VN +SFHPSGNYLITASSD TLKILDL+EGRL+YTL GH GP  TV+F
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241

Query: 279 SKGGELFASGGADTQVLLWRTNFDELHCKGLTK------------RNLKRLHFDSPP 323
           S+ GE FASGG+D QV++W++NFD +    +TK             NL  + F  PP
Sbjct: 242 SRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPP 298



 Score =  176 bits (446), Expect = 4e-44
 Identities = 123/393 (31%), Positives = 177/393 (45%), Gaps = 38/393 (9%)

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D  + +W    + +   F  H   V  V+FS  G  LA+ S DK++++W    +      
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT  VR   F  DG+  V+ S+DKT+K+W T  ++ + + S  + +     F+P G  
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260
           I SA  D+TVK+WD    + +  Y  H G V  + FHPSG  +  A  D T+K+ D+   
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181

Query: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFD 320
           RL+   Q H+  V  +SF   G    +  +D+ + +            +  R L  LH  
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL---------MEGRLLYTLHGH 232

Query: 321 SPPHLLDIYPRTPH-----PHEEKVETVEINPKLEVIDLQISTPPVMDILSFDSTTTTET 375
             P     + RT         +E+V   + N                DI+     T    
Sbjct: 233 QGPATTVAFSRTGEYFASGGSDEQVMVWKSN---------------FDIVDHGEVTKVPR 277

Query: 376 SGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCESQRSIPLAVTDALEHI 435
              TL             P +  P  +P    +  E +   P E   S+P  +T  LEHI
Sbjct: 278 PPATLASSMGNL------PEVDFP--VPPGRGRSVESVQSQPQEPV-SVPQTLTSTLEHI 328

Query: 436 MEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQ 468
           + QL+VLTQTVSILEQRLTLTEDKLK CLENQQ
Sbjct: 329 VGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQ 361



 Score =  110 bits (275), Expect = 3e-24
 Identities = 64/200 (32%), Positives = 92/200 (46%)

Query: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
           F+ H A + S+    +G+   TAS D  + +W        +    H + V   +FSP G 
Sbjct: 61  FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120

Query: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
           L+ SAS D+TV+LW    R     +  H   V  VDF   G  +A A  D ++KVW +  
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180

Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
            R L     H+  V    F P G  +++ S D T+KI D    + +       G A  V 
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240

Query: 194 FNPSGTCIASAGSDQTVKVW 213
           F+ +G   AS GSD+ V VW
Sbjct: 241 FSRTGEYFASGGSDEQVMVW 260



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 26/78 (33%), Positives = 38/78 (48%)

Query: 10  LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
           L ++++ H AA+  L   P+G  L TAS D+ L + +       Y   GH+   T+V FS
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242

Query: 70  PHGNLLASASRDRTVRLW 87
             G   AS   D  V +W
Sbjct: 243 RTGEYFASGGSDEQVMVW 260


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  159 bits (403), Expect = 4e-39
 Identities = 86/285 (30%), Positives = 147/285 (51%), Gaps = 1/285 (0%)

Query: 15  KGHKAAITSLDLS-PNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
           +GH+  + ++  + P G ++AT S+D    LW+ +     + + GH   +  + F+P   
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190

Query: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
           L+A+ S D T +LW      +    + H+A + S+ F+  G  + T S D ++ VW    
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250

Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
            R +  L  H   +  A F+ D  LI++ S DKT K+WD TN +CV   +          
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
           F+ +G  IA+A +D T +++     K +   + H G ++ ISF+P GN+L+T SSD T +
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370

Query: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
           I D   G+ +  L+GHT  +F+ +F+  G +  +G  D    +WR
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415



 Score =  136 bits (343), Expect = 4e-32
 Identities = 78/289 (26%), Positives = 136/289 (47%), Gaps = 1/289 (0%)

Query: 10  LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
           L +  K H   +T++ L+ +G    T S+D    LW+           GH++VV ++ F+
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 70  -PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
            P+G+ +A+ S D+T +LW  +    +  F+ HTA +  + F+     +AT S D + K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203

Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
           W +     +Y+L  H+  +    F+  G  I++ S D T+ +WD    + VN        
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263

Query: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
            +   FN   + I +   D+T K+WD    K +     H   +    F  +G  + TAS+
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 323

Query: 249 DGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
           DGT +I      + I  L+GH G +  +SF+  G    +G +D    +W
Sbjct: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372



 Score =  135 bits (339), Expect = 1e-31
 Identities = 71/241 (29%), Positives = 117/241 (48%)

Query: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
           F+GH A I  L  +P    +AT S DT   LW+ +     Y   GH   + S+ F+  G+
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232

Query: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
            + + S D TV +W  D   K +    H A + S  F+ D   + T S DK+ K+W    
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292

Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
            + + +L  H   +  + F   G+LI + S D T +I+    ++C+       G  + + 
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352

Query: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
           FNP G  + +  SD+T ++WD +  + LQ  + H+  +   +F+  GN +IT S D T +
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412

Query: 254 I 254
           I
Sbjct: 413 I 413


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  150 bits (380), Expect = 2e-36
 Identities = 86/253 (33%), Positives = 137/253 (54%), Gaps = 6/253 (2%)

Query: 57  VGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSVDFSADGQ 115
           VGH + V+SV+FSP+G  LAS+S DR + +W     GK+ +    H   +  V +S+D  
Sbjct: 38  VGHTEAVSSVKFSPNGEWLASSSADRLIIIW-GAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
            L +AS+DK++K+W +   + L +L  H+++V C  F+P   LI+S S D+T+KIW+   
Sbjct: 97  RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156

Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVHSGGVNCI 234
            +C+   S      + V FN SG+ I S   D   ++WD    + L+      +  V+ +
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216

Query: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGELFASGGAD 291
            F P+G Y++TA+ D TLK+ D   GR + T  GH    + +  +FS  GG+   SG  D
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276

Query: 292 TQVLLWRTNFDEL 304
             V +W     E+
Sbjct: 277 NLVYIWNLQTKEI 289



 Score =  139 bits (351), Expect = 4e-33
 Identities = 87/291 (29%), Positives = 141/291 (48%), Gaps = 6/291 (2%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           GH  A++S+  SPNG+ LA++S D  +++W            GH   ++ V +S   + L
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            SAS D+T++LW           K H+  V   +F+     + + S D+++K+W +   +
Sbjct: 99  VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF-SDSVGFANFVDF 194
            L +L  H+  V    F+  G LIVS S D   +IWD  + QC+     D     +FV F
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218

Query: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
           +P+G  I +A  D T+K+WD    + L+ Y  H     CI  + S   G ++++ S D  
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
           + I +L    ++  LQGHT  V + +      L AS     D  + LW +N
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329



 Score =  114 bits (286), Expect = 1e-25
 Identities = 73/255 (28%), Positives = 128/255 (50%), Gaps = 8/255 (3%)

Query: 7   DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
           D   E+   GH   I+ +  S +  +L +AS D  L LW+ +         GH + V   
Sbjct: 72  DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131

Query: 67  QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
            F+P  NL+ S S D TV++W   K GK      AH+ PV +V F+  G  + + S D  
Sbjct: 132 NFNPPSNLIISGSFDETVKIW-EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGL 190

Query: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
            ++W     + L +L    +  V   KFSP+G+ I++ + D T+K+WD +  +C+  ++ 
Sbjct: 191 CRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250

Query: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
             +  +  F +F+   G  I S   D  V +W+++  +++Q  Q H+  V   + HP+ N
Sbjct: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310

Query: 242 YLITAS--SDGTLKI 254
            + +A+  +D T+K+
Sbjct: 311 LIASAALENDKTIKL 325



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 59/186 (31%), Positives = 92/186 (49%)

Query: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
           A  Q   ++S ++S +V          +L  HT  V   KFSP+G  + S S D+ I IW
Sbjct: 9   AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68

Query: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV 231
              + +            + V ++   + + SA  D+T+K+WDVR  K L+  + HS  V
Sbjct: 69  GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128

Query: 232 NCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
            C +F+P  N +I+ S D T+KI ++  G+ + TL  H+ PV  V F+  G L  SG  D
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188

Query: 292 TQVLLW 297
               +W
Sbjct: 189 GLCRIW 194



 Score = 37.0 bits (84), Expect = 0.039
 Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 1/51 (1%)

Query: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLK 315
           TL GHT  V +V FS  GE  AS  AD  +++W   +D  + K L   NL+
Sbjct: 36  TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA-YDGKYEKTLYGHNLE 85


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  149 bits (377), Expect = 4e-36
 Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 6/291 (2%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           GH  A++S+  SPNG+ LA++S D  + +W            GHK  ++ V +S   NLL
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            SAS D+T+++W           K H+  V   +F+     + + S D+S+++W +   +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN-FSDSVGFANFVDF 194
            L +L  H+  V    F+ DG LIVS S D   +IWDT + QC+     D     +FV F
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222

Query: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
           +P+G  I +A  D T+K+WD    K L+ Y  H     CI  + S   G ++++ S D  
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
           + I +L    ++  LQGHT  V + +      + AS     D  + LW+++
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333



 Score =  147 bits (372), Expect = 2e-35
 Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 6/260 (2%)

Query: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSV 108
           +A  +   GH   V+SV+FSP+G  LAS+S D+ +++W     GKF +    H   +  V
Sbjct: 35  YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDV 93

Query: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
            +S+D   L +AS+DK++K+W +   + L +L  H+++V C  F+P   LIVS S D+++
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVH 227
           +IWD    +C+          + V FN  G+ I S+  D   ++WD    + L+      
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213

Query: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGEL 284
           +  V+ + F P+G Y++ A+ D TLK+ D  +G+ + T  GH    + +  +FS  GG+ 
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273

Query: 285 FASGGADTQVLLWRTNFDEL 304
             SG  D  V +W     E+
Sbjct: 274 IVSGSEDNLVYIWNLQTKEI 293



 Score =  118 bits (295), Expect = 1e-26
 Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%)

Query: 7   DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
           D   E+   GHK  I+ +  S +   L +AS D  L +W+           GH + V   
Sbjct: 76  DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135

Query: 67  QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
            F+P  NL+ S S D +VR+W   K GK      AH+ PV +V F+ DG  + ++S D  
Sbjct: 136 NFNPQSNLIVSGSFDESVRIW-DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194

Query: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
            ++W     + L +L    +  V   KFSP+G+ I++ + D T+K+WD +  +C+  ++ 
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254

Query: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
             +  +  F +F+   G  I S   D  V +W+++  +++Q  Q H+  V   + HP+ N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314

Query: 242 YLITAS--SDGTLKI 254
            + +A+  +D T+K+
Sbjct: 315 IIASAALENDKTIKL 329


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  149 bits (377), Expect = 4e-36
 Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 6/291 (2%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           GH  A++S+  SPNG+ LA++S D  + +W            GHK  ++ V +S   NLL
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            SAS D+T+++W           K H+  V   +F+     + + S D+S+++W +   +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN-FSDSVGFANFVDF 194
            L +L  H+  V    F+ DG LIVS S D   +IWDT + QC+     D     +FV F
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222

Query: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
           +P+G  I +A  D T+K+WD    K L+ Y  H     CI  + S   G ++++ S D  
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
           + I +L    ++  LQGHT  V + +      + AS     D  + LW+++
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333



 Score =  147 bits (372), Expect = 2e-35
 Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 6/260 (2%)

Query: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSV 108
           +A  +   GH   V+SV+FSP+G  LAS+S D+ +++W     GKF +    H   +  V
Sbjct: 35  YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDV 93

Query: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
            +S+D   L +AS+DK++K+W +   + L +L  H+++V C  F+P   LIVS S D+++
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVH 227
           +IWD    +C+          + V FN  G+ I S+  D   ++WD    + L+      
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213

Query: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGEL 284
           +  V+ + F P+G Y++ A+ D TLK+ D  +G+ + T  GH    + +  +FS  GG+ 
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273

Query: 285 FASGGADTQVLLWRTNFDEL 304
             SG  D  V +W     E+
Sbjct: 274 IVSGSEDNLVYIWNLQTKEI 293



 Score =  118 bits (295), Expect = 1e-26
 Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%)

Query: 7   DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
           D   E+   GHK  I+ +  S +   L +AS D  L +W+           GH + V   
Sbjct: 76  DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135

Query: 67  QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
            F+P  NL+ S S D +VR+W   K GK      AH+ PV +V F+ DG  + ++S D  
Sbjct: 136 NFNPQSNLIVSGSFDESVRIW-DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194

Query: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
            ++W     + L +L    +  V   KFSP+G+ I++ + D T+K+WD +  +C+  ++ 
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254

Query: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
             +  +  F +F+   G  I S   D  V +W+++  +++Q  Q H+  V   + HP+ N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314

Query: 242 YLITAS--SDGTLKI 254
            + +A+  +D T+K+
Sbjct: 315 IIASAALENDKTIKL 329


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  143 bits (360), Expect = 4e-34
 Identities = 94/299 (31%), Positives = 143/299 (47%), Gaps = 5/299 (1%)

Query: 1   MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60
           ++ A  D  L+  F+ H+  ++ + + P+   L +   D    +             GH 
Sbjct: 335 LSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT 394

Query: 61  DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
           D ++   F P G+ LA++S D TV+LW   K      F+ H+  V S  + + G F+A++
Sbjct: 395 DWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454

Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
           S DK+ K+W +  +R   +LY HT  V   +F P    +++ S DKT+ IWD     C  
Sbjct: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514

Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV--NCISFHP 238
           +    +   N   F+P G  IAS  +    K+WD R  KLL    +  G    N ++F  
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPGNEVNFDS 572

Query: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
           SG  L  AS +G + +LDL  G  I+ L GH     TV FS  GE+  SGG+D  V  W
Sbjct: 573 SGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 37/116 (31%), Positives = 58/116 (50%), Gaps = 2/116 (1%)

Query: 192 VDFNPSGTCIASAGSDQTVKVWDV-RVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
           V   P    + S G D+  KV  + + N LL  +  H+  ++   FHPSG+ L T+S D 
Sbjct: 358 VSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFG-HTDWLSDCCFHPSGDKLATSSGDT 416

Query: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHC 306
           T+K+ DL +G  I T +GH+  V++ ++   G   AS   D    +W  N +   C
Sbjct: 417 TVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRC 472



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 1/122 (0%)

Query: 9   VLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQF 68
           + E+   GH  +I      P G  +A+        LW+F+                 V F
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570

Query: 69  SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
              G +LA AS +  + L +  K G+  +   H     +V FS DG+ L +   D +++ 
Sbjct: 571 DSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629

Query: 129 WS 130
           WS
Sbjct: 630 WS 631


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  142 bits (359), Expect = 5e-34
 Identities = 83/308 (26%), Positives = 133/308 (43%), Gaps = 21/308 (6%)

Query: 11  ERY-FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
           E+Y   GH++ +T +   P    + +AS D  + +W+++         GH D V  + F 
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159

Query: 70  PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
             G LLAS S D T++LW             H   V SV    +G  + +AS DK+IK+W
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219

Query: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
            +     + +   H  WVR  + + DG LI SCS D+T+++W    K+C     +     
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279

Query: 190 NFVDFNPS--------------------GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229
             + + P                     G  + S   D+T+K+WDV     L     H  
Sbjct: 280 ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN 339

Query: 230 GVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289
            V  + FH  G ++++ + D TL++ D    R + TL  H   V ++ F K      +G 
Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGS 399

Query: 290 ADTQVLLW 297
            D  V +W
Sbjct: 400 VDQTVKVW 407



 Score =  139 bits (350), Expect = 6e-33
 Identities = 82/284 (28%), Positives = 132/284 (46%), Gaps = 30/284 (10%)

Query: 1   MASATEDPVL----------ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH 50
           M SA+ED  +          ER  KGH  ++  +    +GK LA+ S D  + LW+F+  
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182

Query: 51  ARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110
                  GH   V+SV   P+G+ + SASRD+T+++W          F  H   VR V  
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242

Query: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD--------------- 155
           + DG  +A+ S D++++VW +  +     L  H H V C  ++P+               
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302

Query: 156 -----GRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
                G  ++S S DKTIK+WD +   C+        +   V F+  G  I S   D+T+
Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362

Query: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
           +VWD +  + ++    H   V  + FH +  Y++T S D T+K+
Sbjct: 363 RVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406



 Score =  131 bits (329), Expect = 2e-30
 Identities = 67/225 (29%), Positives = 114/225 (50%), Gaps = 20/225 (8%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R   GH   ++S+ + PNG  + +AS D  + +W  +       + GH++ V  V+ +  
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSAD------------------ 113
           G L+AS S D+TVR+W+   +   +E + H   V  + ++ +                  
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305

Query: 114 --GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
             G FL + S DK+IK+W +     L +L  H +WVR   F   G+ I+SC++DKT+++W
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365

Query: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
           D  NK+C+   +    F   +DF+ +   + +   DQTVKVW+ R
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  139 bits (350), Expect = 6e-33
 Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 1/237 (0%)

Query: 57  VGHKDVVTSVQFSP-HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
           V H   V+S+      G LLA+   D  V LW  +K         HT+PV SV  +   +
Sbjct: 17  VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEE 76

Query: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
            +   S+  SI+VW +   + L +L  H   +    F P G  + S S+D  IK+WD   
Sbjct: 77  LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136

Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
           K CV  +         + F+P G  +ASA  D TVK+WD+   K++  +  H+G VN + 
Sbjct: 137 KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVE 196

Query: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
           FHP+   L + SSD T++  DL + +++  ++G  GPV +V F+  G    SG  D+
Sbjct: 197 FHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253



 Score =  134 bits (336), Expect = 2e-31
 Identities = 70/234 (29%), Positives = 124/234 (52%), Gaps = 1/234 (0%)

Query: 17  HKAAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           H + ++SL L   +G+ LAT   D  + LW+           GH   V SV+ +    L+
Sbjct: 19  HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            + S+  ++R+W  +          H A + S+DF   G+F+A+ S+D +IK+W + R+ 
Sbjct: 79  VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
            ++    H+  VRC +FSPDG+ + S ++D T+K+WD T  + ++ F    G  N V+F+
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198

Query: 196 PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249
           P+   +AS  SD+T++ WD+   +++   +   G V  + F+P G  L +   D
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252



 Score =  127 bits (319), Expect = 2e-29
 Identities = 67/205 (32%), Positives = 104/205 (50%), Gaps = 1/205 (0%)

Query: 94  KFSEFKAHTAPVRSVDFS-ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKF 152
           K  E  AH + V S+    A G+ LAT  +D  + +WS+ +   + SL  HT  V   + 
Sbjct: 12  KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71

Query: 153 SPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
           +    LIV+ S+  +I++WD    + +            +DF+P G  +AS   D  +K+
Sbjct: 72  NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131

Query: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP 272
           WD+R    +  Y+ HS  V C+ F P G +L +A+ D T+K+ DL  G+++    GHTGP
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191

Query: 273 VFTVSFSKGGELFASGGADTQVLLW 297
           V  V F     L ASG +D  +  W
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFW 216



 Score =  112 bits (280), Expect = 7e-25
 Identities = 57/192 (29%), Positives = 99/192 (51%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           GH + + S+ L+   + +   S    + +W+ +        +GHK  + S+ F P+G  +
Sbjct: 61  GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
           AS S+D  ++LW   ++G    ++ H+  VR + FS DG++LA+A++D ++K+W +   +
Sbjct: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
            +     HT  V   +F P+  L+ S S D+TI+ WD    Q V+      G    V FN
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240

Query: 196 PSGTCIASAGSD 207
           P G C+ S   D
Sbjct: 241 PDGCCLYSGCQD 252



 Score =  108 bits (271), Expect = 8e-24
 Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 1/167 (0%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R   GHKA I SLD  P G+ +A+ S DT + LW+ +     +RY GH   V  ++FSP 
Sbjct: 99  RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD 158

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
           G  LASA+ D TV+LW        SEF  HT PV  V+F  +   LA+ S D++I+ W +
Sbjct: 159 GKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218

Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
            + + +  +      VR   F+PDG  + S  +D +++++    ++C
Sbjct: 219 EKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  136 bits (343), Expect = 4e-32
 Identities = 75/277 (27%), Positives = 140/277 (50%), Gaps = 11/277 (3%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +T++D++ +   +A    D+ + +W+  P             + SV+ +   +L+   S 
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D   R+       +      H+ PV    FS D  +L ++SED ++++WS+     L   
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             H + V   +FSP G   VS   D+  ++W T + Q +  F+  +   N   F+P+   
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641

Query: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260
           +A+  +D+TV++WDV     ++ +  H G ++ ++F P+G +L T ++DG + + D+  G
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701

Query: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
            ++  L+GHT  V ++ FS+ GE+ ASG  D  V LW
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score =  110 bits (276), Expect = 2e-24
 Identities = 58/202 (28%), Positives = 96/202 (47%)

Query: 58  GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFL 117
           GH   V    FSP  N L S+S D TVRLW          +K H  PV    FS  G + 
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600

Query: 118 ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ 177
            +   D+  ++W+    + L     H   V C +F P+   + + S D+T+++WD  N  
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660

Query: 178 CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
           CV  F+   G  + + F+P+G  +A+  +D  V +WD+    ++   + H+  V  + F 
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720

Query: 238 PSGNYLITASSDGTLKILDLLE 259
             G  L + S D T+++ D ++
Sbjct: 721 RDGEILASGSMDNTVRLWDAIK 742



 Score =  102 bits (254), Expect = 8e-22
 Identities = 54/199 (27%), Positives = 85/199 (42%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           GH   +     SP+   L ++S D  + LW+ +       Y GH   V   QFSP+G   
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            S   DR  RLW  D       F  H A V    F  +  ++AT S D+++++W +    
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
            +     H   +    FSP+GR + + + D  + +WD  +   V            + F+
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720

Query: 196 PSGTCIASAGSDQTVKVWD 214
             G  +AS   D TV++WD
Sbjct: 721 RDGEILASGSMDNTVRLWD 739



 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 51/159 (32%), Positives = 75/159 (47%)

Query: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
           +KGH   +     SP G    +   D    LW    +     + GH   V   +F P+ N
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640

Query: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
            +A+ S DRTVRLW          F  H  P+ S+ FS +G+FLAT + D  + +W +  
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700

Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
              +  L  HT  V   +FS DG ++ S S D T+++WD
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 42/118 (35%), Positives = 59/118 (50%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R F GH A +      PN   +AT S D  + LW+         + GHK  + S+ FSP+
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
           G  LA+ + D  V LW         E K HT  V S+ FS DG+ LA+ S D ++++W
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 15/148 (10%)

Query: 155 DGRLIVSCSEDKTIKIWDTTNKQC--VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
           D  LI     D T+++W  T K+   V   SD              + I     D   ++
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDL-------------SLIDKESDDVLERI 527

Query: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP 272
            D +    L+    HSG V   SF P  NYL+++S DGT+++  L     +   +GH  P
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587

Query: 273 VFTVSFSKGGELFASGGADTQVLLWRTN 300
           V+   FS  G  F SGG D    LW T+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATD 615


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  134 bits (336), Expect = 2e-31
 Identities = 84/283 (29%), Positives = 137/283 (48%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD +  G  LAT S+D F  +W  K    A     HK  + +++++  GN + SA  
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+ ++  F A+ S D  I V  + + R + + 
Sbjct: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRPIKTF 345

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGT- 199
             HT+ V   K+ P G L+ SCS+D T+KIW      CV++          + ++P+G  
Sbjct: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405

Query: 200 --------CIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WDV     +     H   V  ++F P G YL + S D  
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSV 507



 Score =  115 bits (287), Expect = 1e-25
 Identities = 79/308 (25%), Positives = 138/308 (44%), Gaps = 25/308 (8%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA------YRYV---GHKDV--- 62
           +GH++ +     +P    LA+ S D+   +WN   ++ +       R+    G +DV   
Sbjct: 166 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSN 225

Query: 63  --VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
             VTS+ ++  G LLA+ S D   R+W  D     S    H  P+ ++ ++  G F+ +A
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIWTKDGN-LASTLGQHKGPIFALKWNKKGNFILSA 284

Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
             DK+  +W  +          H+       +  +     SCS D  I +      + + 
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRPIK 343

Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG 240
            F       N + ++P+G  +AS   D T+K+W ++ +  +   Q H+  +  I + P+G
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403

Query: 241 N---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
                      L +AS D T+++ D+  G  I+TL  H  PV++V+FS  G   ASG  D
Sbjct: 404 PGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463

Query: 292 TQVLLWRT 299
             V +W T
Sbjct: 464 KCVHIWNT 471



 Score =  100 bits (248), Expect = 4e-21
 Identities = 73/272 (26%), Positives = 120/272 (44%), Gaps = 25/272 (9%)

Query: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKA-------- 100
           P  +A    GH+  V    ++P  +LLAS S D T R+W   +       +         
Sbjct: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217

Query: 101 ------HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
                     V S+D++++G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNK 276

Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCK 335

Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
           +  ++ ++ +Q H+  VN I + P+GN L + S D TLKI  + +   ++ LQ H   ++
Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395

Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
           T+ +S  G          + AS   D+ V LW
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLW 427



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 60/215 (27%), Positives = 106/215 (49%), Gaps = 11/215 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            GNLLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 360 TGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASAS 419

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + R   +++L +H   V    FSPDGR + S S DK + IW+T     V++
Sbjct: 420 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 479

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
           +  + G    V +N +G  + ++ SD +V V D+R
Sbjct: 480 YRGTGGIFE-VCWNAAGDKVGASASDGSVCVLDLR 513



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/124 (27%), Positives = 56/124 (45%), Gaps = 15/124 (12%)

Query: 194 FNPSGTCIASAGSDQTVKVWDVRVN------KLLQHYQVHSGG--------VNCISFHPS 239
           +NP    +AS   D T ++W++  N      +L+  + +  GG        V  + ++  
Sbjct: 177 WNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSE 236

Query: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
           G  L T S DG  +I    +G L  TL  H GP+F + ++K G    S G D   ++W  
Sbjct: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295

Query: 300 NFDE 303
           +  E
Sbjct: 296 HTGE 299


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  131 bits (330), Expect = 1e-30
 Identities = 85/291 (29%), Positives = 127/291 (43%), Gaps = 9/291 (3%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL- 74
           G    I+    SPN K LATA W     LW+       +   GH   V ++ F P   + 
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288

Query: 75  -------LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
                  LAS + D +V+LW  D     ++ + HT  V  V +   G+FL T   D+S +
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348

Query: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
           +W +  Q  +     H+  V    F  DG L  +   D   ++WD    +C+      + 
Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408

Query: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITA 246
               ++F+P+G  IA+   D T KVWD+R  + +     H   V  + F P  GN+L+T 
Sbjct: 409 EIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTG 468

Query: 247 SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
           + D T KI        + TL GH G V  +  S  G+L A+   D    LW
Sbjct: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 53/210 (25%), Positives = 94/210 (44%), Gaps = 3/210 (1%)

Query: 5   TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64
           +++PV +   +GH   +  +   P+G+ L T  +D    LW+ +         GH   V 
Sbjct: 312 SDEPVAD--IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVY 369

Query: 65  SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK 124
            + F   G+L  +   D   R+W           + H   +  ++FS +G  +AT S D 
Sbjct: 370 DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDN 429

Query: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183
           + KVW + ++R +Y++  H + V   KF P  G  +++ + D T KIW       +   +
Sbjct: 430 TCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLA 489

Query: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
              G    +D +  G  IA+   D+T K+W
Sbjct: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 30/121 (24%), Positives = 47/121 (38%), Gaps = 43/121 (35%)

Query: 13  YFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP-H 71
           + +GH   I  ++ SPNG  +AT S D    +W+ +     Y    H+++VT V+F P H
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461

Query: 72  GN------------------------------------------LLASASRDRTVRLWIP 89
           GN                                          L+A+ S DRT +LW+ 
Sbjct: 462 GNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521

Query: 90  D 90
           +
Sbjct: 522 E 522



 Score = 36.2 bits (82), Expect = 0.067
 Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 8/76 (10%)

Query: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG--------PVFTVSFSKGGELFAS 287
           F P+   L TA   G  K+  + +  L++TL+GH          P  TVS        AS
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298

Query: 288 GGADTQVLLWRTNFDE 303
             AD  V LW  + DE
Sbjct: 299 CAADGSVKLWSLDSDE 314


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  130 bits (326), Expect = 3e-30
 Identities = 85/286 (29%), Positives = 135/286 (47%), Gaps = 10/286 (3%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           ++F  H   + S   SP+G+ L T S D  +  W  +     +R  GH   V   +FSP 
Sbjct: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
           G+L ASAS D TVRLW   +       K H   V +V FS D + LA+   DK + +W +
Sbjct: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134

Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD------TTNKQCVNNFSDS 185
              + L  L  H   ++ + FSP    + + S D T+ IWD        + Q +   S +
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194

Query: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
           +   + + ++ SG  +AS   D+T+ +W    + LL   + H   V  I+F P   +L +
Sbjct: 195 I---SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250

Query: 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
           A     +K+ D   G+ + TL+G      T +F+  G++  SG AD
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296



 Score =  122 bits (305), Expect = 9e-28
 Identities = 64/201 (31%), Positives = 99/201 (49%), Gaps = 4/201 (1%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R  KGH+ ++ ++  SP+ +QLA+  WD  +MLW+ +        VGH+D + S  FSP 
Sbjct: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158

Query: 72  GNLLASASRDRTVRLW---IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
            N LA+ S D TV +W   +          + H+A +  + +SA G  LA+ S DK+I +
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHI 217

Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
           W       L  L  H  WV+   FSPD   + S    + +K+WD    +C+      +  
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277

Query: 189 ANFVDFNPSGTCIASAGSDQT 209
           A+   F P G  + S  +DQT
Sbjct: 278 AHTCAFTPDGKILVSGAADQT 298



 Score =  120 bits (302), Expect = 2e-27
 Identities = 79/253 (31%), Positives = 116/253 (45%), Gaps = 5/253 (1%)

Query: 52  RAYRYVG-HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110
           R  ++ G H   V S  FSP G +L + S D  V  W             HT PV+   F
Sbjct: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71

Query: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKI 170
           S DG   A+AS D ++++W + R + L  L  H   V    FSPD R + S   DK + +
Sbjct: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131

Query: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR-VNKLLQHYQV--H 227
           WD  + Q +             DF+P+  C+A+   D TV +WD+R V   + H  +  H
Sbjct: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191

Query: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFAS 287
           S  ++C+ +  SG  L + S D T+ I       L+  L+GH   V +++FS      AS
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250

Query: 288 GGADTQVLLWRTN 300
            G    V +W  N
Sbjct: 251 AGYSRMVKVWDCN 263



 Score =  115 bits (287), Expect = 1e-25
 Identities = 73/220 (33%), Positives = 105/220 (47%), Gaps = 12/220 (5%)

Query: 91  KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150
           +R KF  F  H   V S  FS DGQ L T SED  +  W     + L+ L  HT  V+  
Sbjct: 12  RRVKF--FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC 69

Query: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
           +FSPDG L  S S D T+++WD    +C+            V F+P    +AS G D+ V
Sbjct: 70  RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129

Query: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI------Y 264
            +WDV+  ++L+    H   +    F P+ N L T S D T+ I DL   R++       
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL---RMVTPAVSHQ 186

Query: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
            L+GH+  +  + +S  G L ASG  D  + +W+     L
Sbjct: 187 ALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL 225



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 54/168 (32%), Positives = 85/168 (50%), Gaps = 4/168 (2%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK---PHARAYRYVGHKDVVTSVQF 68
           R   GH+ +I S D SP    LAT SWD+ + +W+ +   P        GH   ++ + +
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200

Query: 69  SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
           S  G LLAS S D+T+ +W P       + K H   V+S+ FS D  +LA+A   + +KV
Sbjct: 201 SASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259

Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
           W     + L +L           F+PDG+++VS + D+T +    T+K
Sbjct: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  129 bits (324), Expect = 6e-30
 Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + NG  LAT S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 298

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +   R + + 
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 357

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW    + C+++          + ++P+G  
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WD+           H   V  ++F P G YL + S D  
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 478 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 519



 Score =  114 bits (284), Expect = 3e-25
 Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++ +G LLA+ S D   R+W  D     S    H  P+ ++ ++  G ++ +
Sbjct: 238 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 295

Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
           A  DK+  +W  +    +Q+F +  +      W     F+       SCS D  I +   
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348

Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
              + V  F       N + ++PSG  +AS   D T+K+W ++    +   Q H+  +  
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408

Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
           I + P+G           L +AS D T+++ D+  G   +TL  H  PV++V+FS  G+ 
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468

Query: 285 FASGGADTQVLLWRTNFDEL 304
            ASG  D  V +W T    L
Sbjct: 469 LASGSFDKCVHIWNTQSGNL 488



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)

Query: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
           P ++A    GH+  V    ++P  +LLAS S D T R+W  ++       +         
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229

Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
             H  P    V S+D++ +G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 288

Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 289 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 347

Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
           +  ++ ++ +Q H+  VN I + PSG  L + S D TLKI  + +   I+ LQ H   ++
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407

Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
           T+ +S  G          + AS   D+ V LW
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 313 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 372 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + R    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
           +  + G    V +N  G  + ++ SD +V V D+R
Sbjct: 492 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 525



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 211


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  129 bits (324), Expect = 6e-30
 Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + NG  LAT S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 298

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +   R + + 
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 357

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW    + C+++          + ++P+G  
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WD+           H   V  ++F P G YL + S D  
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 478 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 519



 Score =  114 bits (284), Expect = 3e-25
 Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++ +G LLA+ S D   R+W  D     S    H  P+ ++ ++  G ++ +
Sbjct: 238 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 295

Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
           A  DK+  +W  +    +Q+F +  +      W     F+       SCS D  I +   
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348

Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
              + V  F       N + ++PSG  +AS   D T+K+W ++    +   Q H+  +  
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408

Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
           I + P+G           L +AS D T+++ D+  G   +TL  H  PV++V+FS  G+ 
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468

Query: 285 FASGGADTQVLLWRTNFDEL 304
            ASG  D  V +W T    L
Sbjct: 469 LASGSFDKCVHIWNTQSGNL 488



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)

Query: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
           P ++A    GH+  V    ++P  +LLAS S D T R+W  ++       +         
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229

Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
             H  P    V S+D++ +G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 288

Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 289 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 347

Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
           +  ++ ++ +Q H+  VN I + PSG  L + S D TLKI  + +   I+ LQ H   ++
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407

Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
           T+ +S  G          + AS   D+ V LW
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 313 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 372 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + R    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
           +  + G    V +N  G  + ++ SD +V V D+R
Sbjct: 492 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 525



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 211


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  129 bits (324), Expect = 6e-30
 Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + NG  LAT S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 349

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +   R + + 
Sbjct: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 408

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW    + C+++          + ++P+G  
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WD+           H   V  ++F P G YL + S D  
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 529 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570



 Score =  114 bits (284), Expect = 3e-25
 Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++ +G LLA+ S D   R+W  D     S    H  P+ ++ ++  G ++ +
Sbjct: 289 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 346

Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
           A  DK+  +W  +    +Q+F +  +      W     F+       SCS D  I +   
Sbjct: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399

Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
              + V  F       N + ++PSG  +AS   D T+K+W ++    +   Q H+  +  
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459

Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
           I + P+G           L +AS D T+++ D+  G   +TL  H  PV++V+FS  G+ 
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519

Query: 285 FASGGADTQVLLWRTNFDEL 304
            ASG  D  V +W T    L
Sbjct: 520 LASGSFDKCVHIWNTQSGNL 539



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)

Query: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
           P ++A    GH+  V    ++P  +LLAS S D T R+W  ++       +         
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280

Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
             H  P    V S+D++ +G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 339

Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398

Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
           +  ++ ++ +Q H+  VN I + PSG  L + S D TLKI  + +   I+ LQ H   ++
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458

Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
           T+ +S  G          + AS   D+ V LW
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 364 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 423 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + R    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
           +  + G    V +N  G  + ++ SD +V V D+R
Sbjct: 543 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 576



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 262


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  129 bits (324), Expect = 6e-30
 Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + NG  LAT S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 349

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +   R + + 
Sbjct: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 408

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW    + C+++          + ++P+G  
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WD+           H   V  ++F P G YL + S D  
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 529 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570



 Score =  114 bits (284), Expect = 3e-25
 Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++ +G LLA+ S D   R+W  D     S    H  P+ ++ ++  G ++ +
Sbjct: 289 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 346

Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
           A  DK+  +W  +    +Q+F +  +      W     F+       SCS D  I +   
Sbjct: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399

Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
              + V  F       N + ++PSG  +AS   D T+K+W ++    +   Q H+  +  
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459

Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
           I + P+G           L +AS D T+++ D+  G   +TL  H  PV++V+FS  G+ 
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519

Query: 285 FASGGADTQVLLWRTNFDEL 304
            ASG  D  V +W T    L
Sbjct: 520 LASGSFDKCVHIWNTQSGNL 539



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)

Query: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
           P ++A    GH+  V    ++P  +LLAS S D T R+W  ++       +         
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280

Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
             H  P    V S+D++ +G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 339

Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398

Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
           +  ++ ++ +Q H+  VN I + PSG  L + S D TLKI  + +   I+ LQ H   ++
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458

Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
           T+ +S  G          + AS   D+ V LW
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 364 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 423 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + R    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
           +  + G    V +N  G  + ++ SD +V V D+R
Sbjct: 543 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 576



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 262


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  129 bits (324), Expect = 6e-30
 Identities = 93/333 (27%), Positives = 149/333 (44%), Gaps = 50/333 (15%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSP-HG 72
           KGH+  + S+  SP+G++LA+   +  ++LW+     +  R + GH   +T + + P H 
Sbjct: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212

Query: 73  N----LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
           N     +AS+S+D +VR+W             HT  V  + +  DG  L +AS+D++IKV
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271

Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRL------------------------------ 158
           W  +      +L  H HWV     S D  L                              
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331

Query: 159 ------------IVSCSEDKTIKIWDTT-NKQCVNNFSDSVGFANFVDFNPSGTCIASAG 205
                       +VS S+D T+ +W    +K+ +   +      N V F+P    +ASA 
Sbjct: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391

Query: 206 SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
            D+++K+WD R  K L   + H   V  I++      L++ SSD TLK+ D+   +L   
Sbjct: 392 FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD 451

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
           L GH   V+ V +S  G+  ASGG D  + +WR
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484



 Score =  112 bits (281), Expect = 6e-25
 Identities = 89/375 (23%), Positives = 157/375 (41%), Gaps = 63/375 (16%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
           +GH  A+ S+  SP GK LA+ S DT +  W+       +   GH+  V S+ +SP G  
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170

Query: 75  LASASRDRTVRLWIPDKRGKFSEFKA-HTAPVRSVDF-----SADGQFLATASEDKSIKV 128
           LAS  ++  + LW P    +     A H+  +  + +     + + +++A++S+D S+++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230

Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK----------QC 178
           W     R    L  HT  V C ++  DG L+ S S+D+TIK+W   +             
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289

Query: 179 VNNFSDSVGFANFVD-FNPSGTCI-------------------------------ASAGS 206
           VN  + S  +A     F P+   +                                S   
Sbjct: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349

Query: 207 DQTVKVWDVRVNKL-LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
           D T+ +W    +K  L     H   +N + F P    + +AS D ++K+ D   G+ + +
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHL 325
           L+GH   V+ +++S    L  SG +D+ + +W                 ++L  D P H 
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV-------------KAQKLAMDLPGHA 456

Query: 326 LDIYPRTPHPHEEKV 340
            ++Y     P  ++V
Sbjct: 457 DEVYAVDWSPDGQRV 471



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 66/231 (28%), Positives = 109/231 (47%), Gaps = 11/231 (4%)

Query: 96  SEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD 155
           S  + H+  V SV FS  G++LA+ S D +++ W +  +   ++   H HWV    +SPD
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167

Query: 156 GRLIVSCSEDKTIKIWD-TTNKQCVNNFSDSVGFANFVDF-----NPSGTCIASAGSDQT 209
           GR + S  ++  I +WD +T KQ     +    +   + +     NP    +AS+  D +
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227

Query: 210 VKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH 269
           V++WD    +  +    H+  V C+ +   G  L +AS D T+K+    +G L  TLQGH
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 286

Query: 270 TGPVFTVSFSKGGEL----FASGGADTQVLLWRTNFDELHCKGLTKRNLKR 316
              V T++ S    L    F    A       + +  EL  + L++ NL R
Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 38/127 (29%), Positives = 63/127 (49%)

Query: 3   SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV 62
           S  ED        GH+A I  +  SP+ + +A+AS+D  + LW+ +         GH   
Sbjct: 357 SPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAA 416

Query: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
           V  + +S    LL S S D T+++W    +    +   H   V +VD+S DGQ +A+  +
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 476

Query: 123 DKSIKVW 129
           DK +++W
Sbjct: 477 DKCLRIW 483



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 28/81 (34%), Positives = 43/81 (53%)

Query: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV 276
           V +     + HS  V  ++F P+G YL + S D T++  DL      +T +GH   V ++
Sbjct: 103 VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSI 162

Query: 277 SFSKGGELFASGGADTQVLLW 297
           S+S  G   ASG  + Q+LLW
Sbjct: 163 SWSPDGRKLASGCKNGQILLW 183



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)

Query: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELH--CKG 308
           R   +L+GH+  V +V+FS  G+  ASG  DT V  W  + +  H  CKG
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKG 154


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  125 bits (314), Expect = 8e-29
 Identities = 80/304 (26%), Positives = 144/304 (47%), Gaps = 13/304 (4%)

Query: 3   SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKD 61
           S+ + P++     GH+  +      PNG  LA+A +D  ++LWN       Y  + GH  
Sbjct: 53  SSLQAPIM--LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110

Query: 62  VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG-QFLATA 120
            V  + ++  G++L SAS D+TV +W  +   +    K HT+ V S   +  G Q + T 
Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170

Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
           S+D ++K+W + R++     +++T+ V    F+     I+S   D  IK+WD    +   
Sbjct: 171 SDDGTVKLWDI-RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229

Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQ--VHSGGVNCI 234
                      +  +  G+ + S   D TV+VWDVR      + ++ +Q  VH+   N +
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289

Query: 235 --SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
             S+ P G+ +   S+D  + + D    R++Y L GH G +  V+F     +  S  +D 
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349

Query: 293 QVLL 296
           ++ +
Sbjct: 350 RLYM 353



 Score =  124 bits (312), Expect = 1e-28
 Identities = 86/308 (27%), Positives = 143/308 (46%), Gaps = 24/308 (7%)

Query: 58  GHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
           GH+  V   +F P+G+ LASA  DR + LW +      ++  K H+  V  + ++ DG  
Sbjct: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123

Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVR-CAKFSPDGRLIVSCSEDKTIKIWDTTN 175
           L +AS DK++ VW       +  L  HT +V  C       +L+ + S+D T+K+WD   
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183

Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
           K  +  F ++      V FN +   I S G D  +KVWD+R NKL    + H+  V  +S
Sbjct: 184 KAAIQTFQNTYQVLA-VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242

Query: 236 FHPSGNYLITASSDGTLKILDLL----EGRLIYTLQGHTGP----VFTVSFSKGGELFAS 287
               G+YL++ + D T+++ D+     + R +   QG+       +   S+S  G   A+
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 288 GGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINP 347
           G AD  V +W T               +R+ +  P H   I     HP E  + +   + 
Sbjct: 303 GSADRFVYVWDT-------------TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349

Query: 348 KLEVIDLQ 355
           +L + ++Q
Sbjct: 350 RLYMGEIQ 357



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 63/253 (24%), Positives = 103/253 (40%), Gaps = 52/253 (20%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG-N 73
           KGH  A+  L  + +G  L +AS D  + +W+ +   R  R  GH   V S   +  G  
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165

Query: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
           L+ + S D TV+LW   K+     F+ +T  V +V F+     + +   D  IKVW + +
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224

Query: 134 QRFLYSLYRHTHWV---------------------------------RCAK--------- 151
            +  Y++  H   V                                 RC K         
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284

Query: 152 --------FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIAS 203
                   +SPDG  I + S D+ + +WDTT+++ +       G  N V F+P    I S
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIIS 344

Query: 204 AGSDQTVKVWDVR 216
           A SD+ + + +++
Sbjct: 345 ASSDKRLYMGEIQ 357



 Score = 33.9 bits (76), Expect = 0.33
 Identities = 16/40 (40%), Positives = 18/40 (45%)

Query: 263 IYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
           I  L GH G V+   F   G   AS G D  +LLW    D
Sbjct: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD 98


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  125 bits (314), Expect = 8e-29
 Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + +G  LA  S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +     + + 
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW      CV++          + ++P+G  
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WDV           H   V  ++F P G YL + S D  
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ QG TG +F V ++  G+   +  +D  V
Sbjct: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517



 Score =  113 bits (282), Expect = 4e-25
 Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++  G LLA  S D   R+W  +     S    H  P+ ++ ++  G ++ +
Sbjct: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293

Query: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
           A  DK+  +W  +          H+       +  +     SCS D  I +        V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352

Query: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
             F       N + ++PSG  +AS   D T+K+W ++ +  +   Q HS  +  I + P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412

Query: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
           G           L +AS D T+++ D+ +G   +TL  H  PV++V+FS  G+  ASG  
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472

Query: 291 DTQVLLWRTNFDEL 304
           D  V +W T    L
Sbjct: 473 DKYVHIWNTQSGSL 486



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH+  + ++ +S  G           LA+AS
Sbjct: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + +    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
           +  + G    V +N  G  + ++ SD +V V D+
Sbjct: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  125 bits (314), Expect = 8e-29
 Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + +G  LA  S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +     + + 
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW      CV++          + ++P+G  
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WDV           H   V  ++F P G YL + S D  
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ QG TG +F V ++  G+   +  +D  V
Sbjct: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517



 Score =  113 bits (282), Expect = 4e-25
 Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++  G LLA  S D   R+W  +     S    H  P+ ++ ++  G ++ +
Sbjct: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293

Query: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
           A  DK+  +W  +          H+       +  +     SCS D  I +        V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352

Query: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
             F       N + ++PSG  +AS   D T+K+W ++ +  +   Q HS  +  I + P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412

Query: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
           G           L +AS D T+++ D+ +G   +TL  H  PV++V+FS  G+  ASG  
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472

Query: 291 DTQVLLWRTNFDEL 304
           D  V +W T    L
Sbjct: 473 DKYVHIWNTQSGSL 486



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH+  + ++ +S  G           LA+AS
Sbjct: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + +    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
           +  + G    V +N  G  + ++ SD +V V D+
Sbjct: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  125 bits (314), Expect = 8e-29
 Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
           +TSLD + +G  LA  S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296

Query: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +     + + 
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355

Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
             HT+ V   K+ P G L+ SCS+D T+KIW      CV++          + ++P+G  
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415

Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
                    +ASA  D TV++WDV           H   V  ++F P G YL + S D  
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475

Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
           + I +   G L+++ QG TG +F V ++  G+   +  +D  V
Sbjct: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517



 Score =  113 bits (282), Expect = 4e-25
 Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)

Query: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
           +GH++ +     +P    LA+ S D+   +WN   ++             R  GH     
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 60  KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
           KDV TS+ ++  G LLA  S D   R+W  +     S    H  P+ ++ ++  G ++ +
Sbjct: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293

Query: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
           A  DK+  +W  +          H+       +  +     SCS D  I +        V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352

Query: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
             F       N + ++PSG  +AS   D T+K+W ++ +  +   Q HS  +  I + P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412

Query: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
           G           L +AS D T+++ D+ +G   +TL  H  PV++V+FS  G+  ASG  
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472

Query: 291 DTQVLLWRTNFDEL 304
           D  V +W T    L
Sbjct: 473 DKYVHIWNTQSGSL 486



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)

Query: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
            G LLAS S D T+++W   +     + +AH+  + ++ +S  G           LA+AS
Sbjct: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429

Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
            D ++++W + +    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
           +  + G    V +N  G  + ++ SD +V V D+
Sbjct: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522



 Score = 30.0 bits (66), Expect = 4.8
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
           L+GH   VF  +++   +L ASG  D+   +W  N
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  117 bits (292), Expect = 3e-26
 Identities = 60/165 (36%), Positives = 85/165 (51%)

Query: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
           ++GH   +  LD+SP     A+ S D    LW+F        Y GH   V  V+F P+ N
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439

Query: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
            LA+ S D+TVRLW   +      F  H  PV S+ FS +G++LA+A ED+ +K+W +  
Sbjct: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499

Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
                 L  HT  +    FSPD  LI S S D ++++WD  N  C
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544



 Score =  109 bits (273), Expect = 5e-24
 Identities = 73/287 (25%), Positives = 133/287 (46%), Gaps = 16/287 (5%)

Query: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
           F   +  + + ++SP+ K LA    ++ + LW+ +  ++  +   H+  V+ +  +   +
Sbjct: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLR--SKKLKSEPHQVDVSRIHLAC--D 319

Query: 74  LLASASRDRTVRLWIPDKRG-KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM- 131
           +L     +        D  G +    + H  PV S  F AD   L + SED SI+ W + 
Sbjct: 320 ILEEEDDE-------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLG 372

Query: 132 -YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
            +    LY  + +  W      SP      S S D+T ++W       +  ++  +   +
Sbjct: 373 SFTNTVLYQGHAYPVWD--LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430

Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
            V F+P+   +A+  +D+TV++W  +    ++ +  H G V  ++F P+G YL +A  D 
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490

Query: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
            LK+ DL  G L   L+GHT  + +++FS    L AS   D  V +W
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537



 Score =  109 bits (272), Expect = 6e-24
 Identities = 60/205 (29%), Positives = 91/205 (44%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           +  +GH   + S     +   L + S D  +  W+         Y GH   V  +  SP+
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
               AS S DRT RLW  D+      +  H A V  V F  +  +LAT S DK++++WS 
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455

Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
            +   +     H   V    FSP+G+ + S  ED+ +K+WD  +                
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515

Query: 192 VDFNPSGTCIASAGSDQTVKVWDVR 216
           + F+P    IASA  D +V+VWD+R
Sbjct: 516 LTFSPDSGLIASASMDNSVRVWDIR 540



 Score =  106 bits (265), Expect = 4e-23
 Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 6/203 (2%)

Query: 58  GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE---FKAHTAPVRSVDFSADG 114
           GH   V S +F    + L S S D ++R W     G F+    ++ H  PV  +D S   
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYW---DLGSFTNTVLYQGHAYPVWDLDISPYS 396

Query: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
            + A+ S D++ ++WS  R   L     H   V C KF P+   + + S DKT+++W   
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ 456

Query: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 234
               V  F+   G    + F+P+G  +ASAG DQ +K+WD+    L +  + H+  +  +
Sbjct: 457 QGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSL 516

Query: 235 SFHPSGNYLITASSDGTLKILDL 257
           +F P    + +AS D ++++ D+
Sbjct: 517 TFSPDSGLIASASMDNSVRVWDI 539



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 40/170 (23%), Positives = 68/170 (40%), Gaps = 16/170 (9%)

Query: 138 YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPS 197
           Y+ Y     +  A+ SPD +L+ +  ++  IK+W   +K+  +         + VD +  
Sbjct: 262 YAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE-------PHQVDVSRI 314

Query: 198 GTC--IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL 255
                I     D+     D      ++  + H G V    F    + L++ S D +++  
Sbjct: 315 HLACDILEEEDDE-----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYW 369

Query: 256 DLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELH 305
           DL         QGH  PV+ +  S     FASG  D    LW  +FD  +
Sbjct: 370 DLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLW--SFDRTY 417



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 10/58 (17%)

Query: 1   MASATEDPVLERY----------FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK 48
           +ASA ED  L+ +           +GH   ITSL  SP+   +A+AS D  + +W+ +
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540


>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
          Length = 607

 Score =  116 bits (290), Expect = 5e-26
 Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 16/248 (6%)

Query: 59  HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH----TAPVRSVDFSADG 114
           H   V +VQFSP   LLA+   DR V+LW  +  G+  EFK       A + S++F + G
Sbjct: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFDSAG 378

Query: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
            +L  AS D + ++W++   R  ++L  H+  V  AKF  D   IVS S D+T+K+WD  
Sbjct: 379 SYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR 438

Query: 175 NKQCVNN-FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
           +K C+   F+ S    +  D   +  C+ S   D+ ++ WD+R   +++  ++  G +  
Sbjct: 439 SKVCIKTVFAGS----SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKITA 493

Query: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG---HTGPVFT-VSFSKGGELFASGG 289
           +  +P    L++ S D  LK++DL    +  T        G  +T V FS  G   A+G 
Sbjct: 494 LDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGS 553

Query: 290 ADTQVLLW 297
           A+  + +W
Sbjct: 554 AEGSLYIW 561



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 62/238 (26%), Positives = 105/238 (44%), Gaps = 15/238 (6%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           G  A ITS++    G  L  AS D    +W    +   +   GH   V S +F      +
Sbjct: 364 GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARI 423

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            S S DRT++LW  D R K    K   A     D     Q + +   DK I+ W + R  
Sbjct: 424 VSGSHDRTLKLW--DLRSKVC-IKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI-RSE 479

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-----N 190
            +         +     +P+   ++SCS D  +K+ D         FS + GF       
Sbjct: 480 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS-APGFKCGSDWT 538

Query: 191 FVDFNPSGTCIASAGSDQTVKVWDV---RVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
            V F+P G+ +A+  ++ ++ +W V   +V K+L   + HS  +N +++ PSG+++++
Sbjct: 539 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLS--KQHSSSINAVAWSPSGSHVVS 594



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 7/118 (5%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHA--RAYRYVGHK--DVVTSVQFSPHGNLLA 76
           IT+LDL+P   +L + S D  L + + + +A  + +   G K     T V FSP G+ +A
Sbjct: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550

Query: 77  SASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
           + S + ++ +W     GK  +   K H++ + +V +S  G  + +  +     +W+ Y
Sbjct: 551 AGSAEGSLYIWSV-LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQY 607



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 46/220 (20%), Positives = 84/220 (38%), Gaps = 23/220 (10%)

Query: 6   EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHA---RAYRYVGHKDV 62
           +D  L     GH   + S     +  ++ + S D  L LW+ +        +      D+
Sbjct: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDI 455

Query: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
           V + Q    G+       D+ +R W         E +     + ++D + +   L + S 
Sbjct: 456 VCTEQCVMSGHF------DKKIRFWDIRSESIVREMEL-LGKITALDLNPERTELLSCSR 508

Query: 123 DKSIKVWSM----YRQRFLYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT---- 173
           D  +KV  +     +Q F    ++  + W R   FSPDG  + + S + ++ IW      
Sbjct: 509 DDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGK 567

Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
             K      S S+   N V ++PSG+ + S        +W
Sbjct: 568 VEKVLSKQHSSSI---NAVAWSPSGSHVVSVDKGCKAVLW 604



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 42/185 (22%), Positives = 64/185 (34%), Gaps = 60/185 (32%)

Query: 224 YQVHSGGVNCISFHP--------------------------------------------S 239
           +  H G VN + F P                                            +
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377

Query: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW-- 297
           G+YL+ AS+D   +I  + + RL +TL GH+G V +  F        SG  D  + LW  
Sbjct: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437

Query: 298 ------RTNFDELHCKGL--TKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKL 349
                 +T F    C  +  T++ +   HFD      DI        E  V  +E+  K+
Sbjct: 438 RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI------RSESIVREMELLGKI 491

Query: 350 EVIDL 354
             +DL
Sbjct: 492 TALDL 496


>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
          Length = 588

 Score =  116 bits (290), Expect = 5e-26
 Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 16/248 (6%)

Query: 59  HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH----TAPVRSVDFSADG 114
           H   V +VQFSP   LLA+   DR V+LW  +  G+  EFK       A + S++F + G
Sbjct: 302 HDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFDSAG 359

Query: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
            +L  AS D + ++W++   R  ++L  H+  V  AKF  D   IVS S D+T+K+WD  
Sbjct: 360 SYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR 419

Query: 175 NKQCVNN-FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
           +K C+   F+ S    +  D   +  C+ S   D+ ++ WD+R   +++  ++  G +  
Sbjct: 420 SKVCIKTVFAGS----SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKITA 474

Query: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG---HTGPVFT-VSFSKGGELFASGG 289
           +  +P    L++ S D  LK++DL    +  T        G  +T V FS  G   A+G 
Sbjct: 475 LDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGS 534

Query: 290 ADTQVLLW 297
           A+  + +W
Sbjct: 535 AEGSLYIW 542



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 62/238 (26%), Positives = 105/238 (44%), Gaps = 15/238 (6%)

Query: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
           G  A ITS++    G  L  AS D    +W    +   +   GH   V S +F      +
Sbjct: 345 GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARI 404

Query: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
            S S DRT++LW  D R K    K   A     D     Q + +   DK I+ W + R  
Sbjct: 405 VSGSHDRTLKLW--DLRSKVC-IKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI-RSE 460

Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-----N 190
            +         +     +P+   ++SCS D  +K+ D         FS + GF       
Sbjct: 461 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS-APGFKCGSDWT 519

Query: 191 FVDFNPSGTCIASAGSDQTVKVWDV---RVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
            V F+P G+ +A+  ++ ++ +W V   +V K+L   + HS  +N +++ PSG+++++
Sbjct: 520 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLS--KQHSSSINAVAWSPSGSHVVS 575



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 7/118 (5%)

Query: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHA--RAYRYVGHK--DVVTSVQFSPHGNLLA 76
           IT+LDL+P   +L + S D  L + + + +A  + +   G K     T V FSP G+ +A
Sbjct: 472 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 531

Query: 77  SASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
           + S + ++ +W     GK  +   K H++ + +V +S  G  + +  +     +W+ Y
Sbjct: 532 AGSAEGSLYIWSV-LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQY 588



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 46/220 (20%), Positives = 84/220 (38%), Gaps = 23/220 (10%)

Query: 6   EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHA---RAYRYVGHKDV 62
           +D  L     GH   + S     +  ++ + S D  L LW+ +        +      D+
Sbjct: 377 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDI 436

Query: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
           V + Q    G+       D+ +R W         E +     + ++D + +   L + S 
Sbjct: 437 VCTEQCVMSGHF------DKKIRFWDIRSESIVREMEL-LGKITALDLNPERTELLSCSR 489

Query: 123 DKSIKVWSM----YRQRFLYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT---- 173
           D  +KV  +     +Q F    ++  + W R   FSPDG  + + S + ++ IW      
Sbjct: 490 DDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGK 548

Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
             K      S S+   N V ++PSG+ + S        +W
Sbjct: 549 VEKVLSKQHSSSI---NAVAWSPSGSHVVSVDKGCKAVLW 585



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 42/185 (22%), Positives = 64/185 (34%), Gaps = 60/185 (32%)

Query: 224 YQVHSGGVNCISFHP--------------------------------------------S 239
           +  H G VN + F P                                            +
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 358

Query: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW-- 297
           G+YL+ AS+D   +I  + + RL +TL GH+G V +  F        SG  D  + LW  
Sbjct: 359 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 418

Query: 298 ------RTNFDELHCKGL--TKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKL 349
                 +T F    C  +  T++ +   HFD      DI        E  V  +E+  K+
Sbjct: 419 RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI------RSESIVREMELLGKI 472

Query: 350 EVIDL 354
             +DL
Sbjct: 473 TALDL 477


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  114 bits (284), Expect = 3e-25
 Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R   GH   + S  +  N   + + S D  L +WN +     +   GH   V  +    H
Sbjct: 297 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 352

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
              + S SRD T+R+W  +          H A VR V +  DG+ + + + D  +KVW  
Sbjct: 353 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 410

Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
             +  L++L  HT+ V   +F  DG  +VS S D +I++WD     C++  +      + 
Sbjct: 411 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468

Query: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
           ++   +   + S  +D TVK+WD++  + LQ  Q    H   V C+ F+   N++IT+S 
Sbjct: 469 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 524

Query: 249 DGTLKILDLLEGRLIYTL 266
           DGT+K+ DL  G  I  L
Sbjct: 525 DGTVKLWDLKTGEFIRNL 542



 Score =  105 bits (262), Expect = 9e-23
 Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)

Query: 58  GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
           GH D V+T +QF   GN + S S D T+++W             HT  V S     +   
Sbjct: 260 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 315

Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
           + + S D+++KVW+      +++LY HT  VRC       + +VS S D T+++WD    
Sbjct: 316 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 373

Query: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
           QC++     V     V ++  G  + S   D  VKVWD      L   Q H+  V  + F
Sbjct: 374 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 431

Query: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
              G ++++ S D ++++ D+  G  I+TL GH     T        +  SG AD+ V +
Sbjct: 432 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 487

Query: 297 W 297
           W
Sbjct: 488 W 488



 Score =  103 bits (257), Expect = 3e-22
 Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)

Query: 12  RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           +  KGH    IT L     G ++ + S D  L +W+          VGH   V S Q   
Sbjct: 256 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 311

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
             N++ S S DRT+++W  +          HT+ VR +      + + + S D +++VW 
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 369

Query: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
           +   + L+ L  H   VRC ++  DGR +VS + D  +K+WD   + C++          
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427

Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
            + F+  G  + S   D +++VWDV     ++ L  H  + SG           N L++ 
Sbjct: 428 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 479

Query: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
           ++D T+KI D+  G+ + TLQG   H   V  + F+K   + +S   D  V LW
Sbjct: 480 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 531



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
           +++  K+L+ +  H   + C+ F   GN +++ S D TLK+   + G+ + TL GHTG V
Sbjct: 251 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 306

Query: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
           +  S      +  SG  D  + +W     E
Sbjct: 307 W--SSQMRDNIIISGSTDRTLKVWNAETGE 334


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  114 bits (284), Expect = 3e-25
 Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R   GH   + S  +  N   + + S D  L +WN +     +   GH   V  +    H
Sbjct: 415 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 470

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
              + S SRD T+R+W  +          H A VR V +  DG+ + + + D  +KVW  
Sbjct: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528

Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
             +  L++L  HT+ V   +F  DG  +VS S D +I++WD     C++  +      + 
Sbjct: 529 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586

Query: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
           ++   +   + S  +D TVK+WD++  + LQ  Q    H   V C+ F+   N++IT+S 
Sbjct: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 642

Query: 249 DGTLKILDLLEGRLIYTL 266
           DGT+K+ DL  G  I  L
Sbjct: 643 DGTVKLWDLKTGEFIRNL 660



 Score =  105 bits (262), Expect = 9e-23
 Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)

Query: 58  GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
           GH D V+T +QF   GN + S S D T+++W             HT  V S     +   
Sbjct: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433

Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
           + + S D+++KVW+      +++LY HT  VRC       + +VS S D T+++WD    
Sbjct: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491

Query: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
           QC++     V     V ++  G  + S   D  VKVWD      L   Q H+  V  + F
Sbjct: 492 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549

Query: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
              G ++++ S D ++++ D+  G  I+TL GH     T        +  SG AD+ V +
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 605

Query: 297 W 297
           W
Sbjct: 606 W 606



 Score =  103 bits (257), Expect = 3e-22
 Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)

Query: 12  RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           +  KGH    IT L     G ++ + S D  L +W+          VGH   V S Q   
Sbjct: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 429

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
             N++ S S DRT+++W  +          HT+ VR +      + + + S D +++VW 
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487

Query: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
           +   + L+ L  H   VRC ++  DGR +VS + D  +K+WD   + C++          
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545

Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
            + F+  G  + S   D +++VWDV     ++ L  H  + SG           N L++ 
Sbjct: 546 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 597

Query: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
           ++D T+KI D+  G+ + TLQG   H   V  + F+K   + +S   D  V LW
Sbjct: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 649



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
           +++  K+L+ +  H   + C+ F   GN +++ S D TLK+   + G+ + TL GHTG V
Sbjct: 369 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424

Query: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
           +  S      +  SG  D  + +W     E
Sbjct: 425 W--SSQMRDNIIISGSTDRTLKVWNAETGE 452


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  114 bits (284), Expect = 3e-25
 Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)

Query: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
           R   GH   + S  +  N   + + S D  L +WN +     +   GH   V  +    H
Sbjct: 335 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 390

Query: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
              + S SRD T+R+W  +          H A VR V +  DG+ + + + D  +KVW  
Sbjct: 391 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 448

Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
             +  L++L  HT+ V   +F  DG  +VS S D +I++WD     C++  +      + 
Sbjct: 449 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506

Query: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
           ++   +   + S  +D TVK+WD++  + LQ  Q    H   V C+ F+   N++IT+S 
Sbjct: 507 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 562

Query: 249 DGTLKILDLLEGRLIYTL 266
           DGT+K+ DL  G  I  L
Sbjct: 563 DGTVKLWDLKTGEFIRNL 580



 Score =  105 bits (262), Expect = 9e-23
 Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)

Query: 58  GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
           GH D V+T +QF   GN + S S D T+++W             HT  V S     +   
Sbjct: 298 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 353

Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
           + + S D+++KVW+      +++LY HT  VRC       + +VS S D T+++WD    
Sbjct: 354 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 411

Query: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
           QC++     V     V ++  G  + S   D  VKVWD      L   Q H+  V  + F
Sbjct: 412 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469

Query: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
              G ++++ S D ++++ D+  G  I+TL GH     T        +  SG AD+ V +
Sbjct: 470 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 525

Query: 297 W 297
           W
Sbjct: 526 W 526



 Score =  103 bits (257), Expect = 3e-22
 Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)

Query: 12  RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
           +  KGH    IT L     G ++ + S D  L +W+          VGH   V S Q   
Sbjct: 294 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 349

Query: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
             N++ S S DRT+++W  +          HT+ VR +      + + + S D +++VW 
Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 407

Query: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
           +   + L+ L  H   VRC ++  DGR +VS + D  +K+WD   + C++          
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465

Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
            + F+  G  + S   D +++VWDV     ++ L  H  + SG           N L++ 
Sbjct: 466 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 517

Query: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
           ++D T+KI D+  G+ + TLQG   H   V  + F+K   + +S   D  V LW
Sbjct: 518 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 569



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
           +++  K+L+ +  H   + C+ F   GN +++ S D TLK+   + G+ + TL GHTG V
Sbjct: 289 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 344

Query: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
           +  S      +  SG  D  + +W     E
Sbjct: 345 W--SSQMRDNIIISGSTDRTLKVWNAETGE 372


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,120,255
Number of Sequences: 37866
Number of extensions: 866798
Number of successful extensions: 7142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 283
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 2423
Number of HSP's gapped (non-prelim): 1910
length of query: 478
length of database: 18,247,518
effective HSP length: 106
effective length of query: 372
effective length of database: 14,233,722
effective search space: 5294944584
effective search space used: 5294944584
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press