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Search of human proteins with 26665869
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26665869 WD repeat domain 51B [Homo sapiens]
(478 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26665869 WD repeat domain 51B [Homo sapiens] 977 0.0
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 424 e-119
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 424 e-118
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 384 e-106
gi|32189425 WD repeat domain 69 [Homo sapiens] 159 4e-39
gi|23199987 WD repeat domain 5B [Homo sapiens] 150 2e-36
gi|16554629 WD repeat domain 5 [Homo sapiens] 149 4e-36
gi|16554627 WD repeat domain 5 [Homo sapiens] 149 4e-36
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 143 4e-34
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 142 5e-34
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 139 6e-33
gi|21071067 TBP-associated factor 5 [Homo sapiens] 136 4e-32
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 134 2e-31
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 131 1e-30
gi|113865883 WD repeat domain 38 [Homo sapiens] 130 3e-30
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 129 6e-30
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 129 6e-30
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 129 6e-30
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 129 6e-30
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 129 6e-30
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 125 8e-29
gi|19913367 transducin beta-like 1Y [Homo sapiens] 125 8e-29
gi|19913365 transducin beta-like 1Y [Homo sapiens] 125 8e-29
gi|15150805 transducin beta-like 1Y [Homo sapiens] 125 8e-29
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 117 3e-26
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 116 5e-26
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 116 5e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 114 3e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 114 3e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 114 3e-25
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 977 bits (2526), Expect = 0.0
Identities = 478/478 (100%), Positives = 478/478 (100%)
Query: 1 MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60
MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK
Sbjct: 1 MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60
Query: 61 DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA
Sbjct: 61 DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN
Sbjct: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG 240
NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG
Sbjct: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG 240
Query: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN
Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
Query: 301 FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP 360
FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP
Sbjct: 301 FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP 360
Query: 361 VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES 420
VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES
Sbjct: 361 VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES 420
Query: 421 QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS 478
QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS
Sbjct: 421 QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS 478
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 424 bits (1090), Expect = e-119
Identities = 199/334 (59%), Positives = 258/334 (77%), Gaps = 12/334 (3%)
Query: 2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61
A EDP LER+FKGH+ A+T +D S N KQLA+ S D+ LM+W+ KP +RAYR+ GHKD
Sbjct: 3 APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
Query: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F+AHTA VRSV F +DGQ TAS
Sbjct: 63 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
+DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRLIVS S+DKT+K+WD ++++CV++
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
+ + GF +VDF+PSGTCIA+AG D TVKVWDVR ++LLQHYQ+HS VN +SFHPSGN
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301
YLITASSD TLKILDL+EGRL+YTL GH GP TV+FS+ GE FASGG+D QV++W++NF
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
Query: 302 DELHCKGLTK------------RNLKRLHFDSPP 323
D + +TK NL + F PP
Sbjct: 303 DIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPP 336
Score = 197 bits (500), Expect = 2e-50
Identities = 135/418 (32%), Positives = 192/418 (45%), Gaps = 38/418 (9%)
Query: 56 YVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
+ GH+D VT V FS + LAS S D + +W + + F H V V+FS G
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
LA+ S DK++++W + HT VR F DG+ V+ S+DKT+K+W T
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
++ + + S + + F+P G I SA D+TVK+WD + + Y H G V +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVL 295
FHPSG + A D T+K+ D+ RL+ Q H+ V +SF G + +D+ +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 296 LWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPH-----PHEEKVETVEINPKLE 350
+ + R L LH P + RT +E+V + N
Sbjct: 255 ILDL---------MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN---- 301
Query: 351 VIDLQISTPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKT 410
DI+ T TL P + P +P +
Sbjct: 302 -----------FDIVDHGEVTKVPRPPATLASSMGNL------PEVDFP--VPPGRGRSV 342
Query: 411 EDMSDLPCESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQ 468
E + P E S+P +T LEHI+ QL+VLTQTVSILEQRLTLTEDKLK CLENQQ
Sbjct: 343 ESVQSQPQEPV-SVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQ 399
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 424 bits (1089), Expect = e-118
Identities = 194/310 (62%), Positives = 252/310 (81%)
Query: 2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61
A EDP LER+FKGH+ A+T +D S N KQLA+ S D+ LM+W+ KP +RAYR+ GHKD
Sbjct: 3 APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
Query: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F+AHTA VRSV F +DGQ TAS
Sbjct: 63 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
+DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRLIVS S+DKT+K+WD ++++CV++
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
+ + GF +VDF+PSGTCIA+AG D TVKVWDVR ++LLQHYQ+HS VN +SFHPSGN
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301
YLITASSD TLKILDL+EGRL+YTL GH GP TV+FS+ GE FASGG+D QV++W++NF
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
Query: 302 DELHCKGLTK 311
D + +TK
Sbjct: 303 DIVDHGEVTK 312
Score = 140 bits (352), Expect = 3e-33
Identities = 120/371 (32%), Positives = 154/371 (41%), Gaps = 34/371 (9%)
Query: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
FK H V VDFS + + LA+ S D + VW M Q Y H V C FSP G
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
L+ S S DKT++IW K F V F G +A D+TVKVW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
K L H V C F P G +++AS D T+K+ D +++ H G V V
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 278 FSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHE 337
F G A+ G D V +W T R L+ H + + HP
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVR---------THRLLQHYQL----HSAAVNGLSFHPSG 241
Query: 338 EKVETVEINPKLEVIDLQISTPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLM 397
+ T + L+++DL + + + TT RT GE YF +
Sbjct: 242 NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRT----GE----YFASGG-- 290
Query: 398 SPECLPTTTKKKTEDMSDLPCESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTE 457
S E K D+ D ++ P A L M L TVSILEQRLTLTE
Sbjct: 291 SDE--QVMVWKSNFDIVDHGEVTKVPRPPAT---LASSMGNL-----TVSILEQRLTLTE 340
Query: 458 DKLKDCLENQQ 468
DKLK CLENQQ
Sbjct: 341 DKLKQCLENQQ 351
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 384 bits (985), Expect = e-106
Identities = 178/297 (59%), Positives = 232/297 (78%), Gaps = 12/297 (4%)
Query: 39 DTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEF 98
D+ LM+W+ KP +RAYR+ GHKD VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
+AHTA VRSV F +DGQ TAS+DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRL
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
IVS S+DKT+K+WD ++++CV+++ + GF +VDF+PSGTCIA+AG D TVKVWDVR +
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 219 KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSF 278
+LLQHYQ+HS VN +SFHPSGNYLITASSD TLKILDL+EGRL+YTL GH GP TV+F
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241
Query: 279 SKGGELFASGGADTQVLLWRTNFDELHCKGLTK------------RNLKRLHFDSPP 323
S+ GE FASGG+D QV++W++NFD + +TK NL + F PP
Sbjct: 242 SRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPP 298
Score = 176 bits (446), Expect = 4e-44
Identities = 123/393 (31%), Positives = 177/393 (45%), Gaps = 38/393 (9%)
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D + +W + + F H V V+FS G LA+ S DK++++W +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT VR F DG+ V+ S+DKT+K+W T ++ + + S + + F+P G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260
I SA D+TVK+WD + + Y H G V + FHPSG + A D T+K+ D+
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFD 320
RL+ Q H+ V +SF G + +D+ + + + R L LH
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL---------MEGRLLYTLHGH 232
Query: 321 SPPHLLDIYPRTPH-----PHEEKVETVEINPKLEVIDLQISTPPVMDILSFDSTTTTET 375
P + RT +E+V + N DI+ T
Sbjct: 233 QGPATTVAFSRTGEYFASGGSDEQVMVWKSN---------------FDIVDHGEVTKVPR 277
Query: 376 SGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCESQRSIPLAVTDALEHI 435
TL P + P +P + E + P E S+P +T LEHI
Sbjct: 278 PPATLASSMGNL------PEVDFP--VPPGRGRSVESVQSQPQEPV-SVPQTLTSTLEHI 328
Query: 436 MEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQ 468
+ QL+VLTQTVSILEQRLTLTEDKLK CLENQQ
Sbjct: 329 VGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQ 361
Score = 110 bits (275), Expect = 3e-24
Identities = 64/200 (32%), Positives = 92/200 (46%)
Query: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
F+ H A + S+ +G+ TAS D + +W + H + V +FSP G
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
L+ SAS D+TV+LW R + H V VDF G +A A D ++KVW +
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
R L H+ V F P G +++ S D T+KI D + + G A V
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 194 FNPSGTCIASAGSDQTVKVW 213
F+ +G AS GSD+ V VW
Sbjct: 241 FSRTGEYFASGGSDEQVMVW 260
Score = 48.5 bits (114), Expect = 1e-05
Identities = 26/78 (33%), Positives = 38/78 (48%)
Query: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
L ++++ H AA+ L P+G L TAS D+ L + + Y GH+ T+V FS
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
Query: 70 PHGNLLASASRDRTVRLW 87
G AS D V +W
Sbjct: 243 RTGEYFASGGSDEQVMVW 260
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 159 bits (403), Expect = 4e-39
Identities = 86/285 (30%), Positives = 147/285 (51%), Gaps = 1/285 (0%)
Query: 15 KGHKAAITSLDLS-PNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
+GH+ + ++ + P G ++AT S+D LW+ + + + GH + + F+P
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
Query: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
L+A+ S D T +LW + + H+A + S+ F+ G + T S D ++ VW
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
R + L H + A F+ D LI++ S DKT K+WD TN +CV +
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
F+ +G IA+A +D T +++ K + + H G ++ ISF+P GN+L+T SSD T +
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
I D G+ + L+GHT +F+ +F+ G + +G D +WR
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 136 bits (343), Expect = 4e-32
Identities = 78/289 (26%), Positives = 136/289 (47%), Gaps = 1/289 (0%)
Query: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
L + K H +T++ L+ +G T S+D LW+ GH++VV ++ F+
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 70 -PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
P+G+ +A+ S D+T +LW + + F+ HTA + + F+ +AT S D + K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
W + +Y+L H+ + F+ G I++ S D T+ +WD + VN
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
+ FN + I + D+T K+WD K + H + F +G + TAS+
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 323
Query: 249 DGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
DGT +I + I L+GH G + +SF+ G +G +D +W
Sbjct: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 135 bits (339), Expect = 1e-31
Identities = 71/241 (29%), Positives = 117/241 (48%)
Query: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
F+GH A I L +P +AT S DT LW+ + Y GH + S+ F+ G+
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
+ + S D TV +W D K + H A + S F+ D + T S DK+ K+W
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
+ + +L H + + F G+LI + S D T +I+ ++C+ G + +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
FNP G + + SD+T ++WD + + LQ + H+ + +F+ GN +IT S D T +
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
Query: 254 I 254
I
Sbjct: 413 I 413
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 150 bits (380), Expect = 2e-36
Identities = 86/253 (33%), Positives = 137/253 (54%), Gaps = 6/253 (2%)
Query: 57 VGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSVDFSADGQ 115
VGH + V+SV+FSP+G LAS+S DR + +W GK+ + H + V +S+D
Sbjct: 38 VGHTEAVSSVKFSPNGEWLASSSADRLIIIW-GAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
L +AS+DK++K+W + + L +L H+++V C F+P LI+S S D+T+KIW+
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVHSGGVNCI 234
+C+ S + V FN SG+ I S D ++WD + L+ + V+ +
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGELFASGGAD 291
F P+G Y++TA+ D TLK+ D GR + T GH + + +FS GG+ SG D
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276
Query: 292 TQVLLWRTNFDEL 304
V +W E+
Sbjct: 277 NLVYIWNLQTKEI 289
Score = 139 bits (351), Expect = 4e-33
Identities = 87/291 (29%), Positives = 141/291 (48%), Gaps = 6/291 (2%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
GH A++S+ SPNG+ LA++S D +++W GH ++ V +S + L
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
SAS D+T++LW K H+ V +F+ + + S D+++K+W + +
Sbjct: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF-SDSVGFANFVDF 194
L +L H+ V F+ G LIVS S D +IWD + QC+ D +FV F
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
+P+G I +A D T+K+WD + L+ Y H CI + S G ++++ S D
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
+ I +L ++ LQGHT V + + L AS D + LW +N
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 114 bits (286), Expect = 1e-25
Identities = 73/255 (28%), Positives = 128/255 (50%), Gaps = 8/255 (3%)
Query: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
D E+ GH I+ + S + +L +AS D L LW+ + GH + V
Sbjct: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
Query: 67 QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
F+P NL+ S S D TV++W K GK AH+ PV +V F+ G + + S D
Sbjct: 132 NFNPPSNLIISGSFDETVKIW-EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGL 190
Query: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
++W + L +L + V KFSP+G+ I++ + D T+K+WD + +C+ ++
Sbjct: 191 CRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
Query: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
+ + F +F+ G I S D V +W+++ +++Q Q H+ V + HP+ N
Sbjct: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310
Query: 242 YLITAS--SDGTLKI 254
+ +A+ +D T+K+
Sbjct: 311 LIASAALENDKTIKL 325
Score = 98.2 bits (243), Expect = 1e-20
Identities = 59/186 (31%), Positives = 92/186 (49%)
Query: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
A Q ++S ++S +V +L HT V KFSP+G + S S D+ I IW
Sbjct: 9 AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
Query: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV 231
+ + + V ++ + + SA D+T+K+WDVR K L+ + HS V
Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Query: 232 NCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
C +F+P N +I+ S D T+KI ++ G+ + TL H+ PV V F+ G L SG D
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188
Query: 292 TQVLLW 297
+W
Sbjct: 189 GLCRIW 194
Score = 37.0 bits (84), Expect = 0.039
Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLK 315
TL GHT V +V FS GE AS AD +++W +D + K L NL+
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA-YDGKYEKTLYGHNLE 85
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 149 bits (377), Expect = 4e-36
Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 6/291 (2%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
GH A++S+ SPNG+ LA++S D + +W GHK ++ V +S NLL
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
SAS D+T+++W K H+ V +F+ + + S D+S+++W + +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN-FSDSVGFANFVDF 194
L +L H+ V F+ DG LIVS S D +IWDT + QC+ D +FV F
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222
Query: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
+P+G I +A D T+K+WD K L+ Y H CI + S G ++++ S D
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
+ I +L ++ LQGHT V + + + AS D + LW+++
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 147 bits (372), Expect = 2e-35
Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 6/260 (2%)
Query: 50 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSV 108
+A + GH V+SV+FSP+G LAS+S D+ +++W GKF + H + V
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDV 93
Query: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
+S+D L +AS+DK++K+W + + L +L H+++V C F+P LIVS S D+++
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVH 227
+IWD +C+ + V FN G+ I S+ D ++WD + L+
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGEL 284
+ V+ + F P+G Y++ A+ D TLK+ D +G+ + T GH + + +FS GG+
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
Query: 285 FASGGADTQVLLWRTNFDEL 304
SG D V +W E+
Sbjct: 274 IVSGSEDNLVYIWNLQTKEI 293
Score = 118 bits (295), Expect = 1e-26
Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%)
Query: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
D E+ GHK I+ + S + L +AS D L +W+ GH + V
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 67 QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
F+P NL+ S S D +VR+W K GK AH+ PV +V F+ DG + ++S D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIW-DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
++W + L +L + V KFSP+G+ I++ + D T+K+WD + +C+ ++
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
+ + F +F+ G I S D V +W+++ +++Q Q H+ V + HP+ N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
Query: 242 YLITAS--SDGTLKI 254
+ +A+ +D T+K+
Sbjct: 315 IIASAALENDKTIKL 329
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 149 bits (377), Expect = 4e-36
Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 6/291 (2%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
GH A++S+ SPNG+ LA++S D + +W GHK ++ V +S NLL
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
SAS D+T+++W K H+ V +F+ + + S D+S+++W + +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN-FSDSVGFANFVDF 194
L +L H+ V F+ DG LIVS S D +IWDT + QC+ D +FV F
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222
Query: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
+P+G I +A D T+K+WD K L+ Y H CI + S G ++++ S D
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
+ I +L ++ LQGHT V + + + AS D + LW+++
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 147 bits (372), Expect = 2e-35
Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 6/260 (2%)
Query: 50 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSV 108
+A + GH V+SV+FSP+G LAS+S D+ +++W GKF + H + V
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDV 93
Query: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
+S+D L +AS+DK++K+W + + L +L H+++V C F+P LIVS S D+++
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVH 227
+IWD +C+ + V FN G+ I S+ D ++WD + L+
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGEL 284
+ V+ + F P+G Y++ A+ D TLK+ D +G+ + T GH + + +FS GG+
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
Query: 285 FASGGADTQVLLWRTNFDEL 304
SG D V +W E+
Sbjct: 274 IVSGSEDNLVYIWNLQTKEI 293
Score = 118 bits (295), Expect = 1e-26
Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%)
Query: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
D E+ GHK I+ + S + L +AS D L +W+ GH + V
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 67 QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
F+P NL+ S S D +VR+W K GK AH+ PV +V F+ DG + ++S D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIW-DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
++W + L +L + V KFSP+G+ I++ + D T+K+WD + +C+ ++
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
+ + F +F+ G I S D V +W+++ +++Q Q H+ V + HP+ N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
Query: 242 YLITAS--SDGTLKI 254
+ +A+ +D T+K+
Sbjct: 315 IIASAALENDKTIKL 329
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 143 bits (360), Expect = 4e-34
Identities = 94/299 (31%), Positives = 143/299 (47%), Gaps = 5/299 (1%)
Query: 1 MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60
++ A D L+ F+ H+ ++ + + P+ L + D + GH
Sbjct: 335 LSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT 394
Query: 61 DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
D ++ F P G+ LA++S D TV+LW K F+ H+ V S + + G F+A++
Sbjct: 395 DWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
S DK+ K+W + +R +LY HT V +F P +++ S DKT+ IWD C
Sbjct: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV--NCISFHP 238
+ + N F+P G IAS + K+WD R KLL + G N ++F
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPGNEVNFDS 572
Query: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
SG L AS +G + +LDL G I+ L GH TV FS GE+ SGG+D V W
Sbjct: 573 SGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 62.8 bits (151), Expect = 7e-10
Identities = 37/116 (31%), Positives = 58/116 (50%), Gaps = 2/116 (1%)
Query: 192 VDFNPSGTCIASAGSDQTVKVWDV-RVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
V P + S G D+ KV + + N LL + H+ ++ FHPSG+ L T+S D
Sbjct: 358 VSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFG-HTDWLSDCCFHPSGDKLATSSGDT 416
Query: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHC 306
T+K+ DL +G I T +GH+ V++ ++ G AS D +W N + C
Sbjct: 417 TVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRC 472
Score = 46.2 bits (108), Expect = 7e-05
Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 1/122 (0%)
Query: 9 VLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQF 68
+ E+ GH +I P G +A+ LW+F+ V F
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Query: 69 SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
G +LA AS + + L + K G+ + H +V FS DG+ L + D +++
Sbjct: 571 DSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629
Query: 129 WS 130
WS
Sbjct: 630 WS 631
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 142 bits (359), Expect = 5e-34
Identities = 83/308 (26%), Positives = 133/308 (43%), Gaps = 21/308 (6%)
Query: 11 ERY-FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
E+Y GH++ +T + P + +AS D + +W+++ GH D V + F
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159
Query: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
G LLAS S D T++LW H V SV +G + +AS DK+IK+W
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Query: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
+ + + H WVR + + DG LI SCS D+T+++W K+C +
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Query: 190 NFVDFNPS--------------------GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229
+ + P G + S D+T+K+WDV L H
Sbjct: 280 ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN 339
Query: 230 GVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289
V + FH G ++++ + D TL++ D R + TL H V ++ F K +G
Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGS 399
Query: 290 ADTQVLLW 297
D V +W
Sbjct: 400 VDQTVKVW 407
Score = 139 bits (350), Expect = 6e-33
Identities = 82/284 (28%), Positives = 132/284 (46%), Gaps = 30/284 (10%)
Query: 1 MASATEDPVL----------ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH 50
M SA+ED + ER KGH ++ + +GK LA+ S D + LW+F+
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
Query: 51 ARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110
GH V+SV P+G+ + SASRD+T+++W F H VR V
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
Query: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD--------------- 155
+ DG +A+ S D++++VW + + L H H V C ++P+
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
Query: 156 -----GRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
G ++S S DKTIK+WD + C+ + V F+ G I S D+T+
Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
Query: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
+VWD + + ++ H V + FH + Y++T S D T+K+
Sbjct: 363 RVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 131 bits (329), Expect = 2e-30
Identities = 67/225 (29%), Positives = 114/225 (50%), Gaps = 20/225 (8%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R GH ++S+ + PNG + +AS D + +W + + GH++ V V+ +
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSAD------------------ 113
G L+AS S D+TVR+W+ + +E + H V + ++ +
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
Query: 114 --GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
G FL + S DK+IK+W + L +L H +WVR F G+ I+SC++DKT+++W
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Query: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
D NK+C+ + F +DF+ + + + DQTVKVW+ R
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 139 bits (350), Expect = 6e-33
Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 1/237 (0%)
Query: 57 VGHKDVVTSVQFSP-HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
V H V+S+ G LLA+ D V LW +K HT+PV SV + +
Sbjct: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEE 76
Query: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
+ S+ SI+VW + + L +L H + F P G + S S+D IK+WD
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
K CV + + F+P G +ASA D TVK+WD+ K++ + H+G VN +
Sbjct: 137 KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVE 196
Query: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
FHP+ L + SSD T++ DL + +++ ++G GPV +V F+ G SG D+
Sbjct: 197 FHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
Score = 134 bits (336), Expect = 2e-31
Identities = 70/234 (29%), Positives = 124/234 (52%), Gaps = 1/234 (0%)
Query: 17 HKAAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
H + ++SL L +G+ LAT D + LW+ GH V SV+ + L+
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
+ S+ ++R+W + H A + S+DF G+F+A+ S+D +IK+W + R+
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
++ H+ VRC +FSPDG+ + S ++D T+K+WD T + ++ F G N V+F+
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198
Query: 196 PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249
P+ +AS SD+T++ WD+ +++ + G V + F+P G L + D
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 127 bits (319), Expect = 2e-29
Identities = 67/205 (32%), Positives = 104/205 (50%), Gaps = 1/205 (0%)
Query: 94 KFSEFKAHTAPVRSVDFS-ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKF 152
K E AH + V S+ A G+ LAT +D + +WS+ + + SL HT V +
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 153 SPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
+ LIV+ S+ +I++WD + + +DF+P G +AS D +K+
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP 272
WD+R + Y+ HS V C+ F P G +L +A+ D T+K+ DL G+++ GHTGP
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 273 VFTVSFSKGGELFASGGADTQVLLW 297
V V F L ASG +D + W
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 112 bits (280), Expect = 7e-25
Identities = 57/192 (29%), Positives = 99/192 (51%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
GH + + S+ L+ + + S + +W+ + +GHK + S+ F P+G +
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
AS S+D ++LW ++G ++ H+ VR + FS DG++LA+A++D ++K+W + +
Sbjct: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
+ HT V +F P+ L+ S S D+TI+ WD Q V+ G V FN
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
Query: 196 PSGTCIASAGSD 207
P G C+ S D
Sbjct: 241 PDGCCLYSGCQD 252
Score = 108 bits (271), Expect = 8e-24
Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 1/167 (0%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R GHKA I SLD P G+ +A+ S DT + LW+ + +RY GH V ++FSP
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD 158
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
G LASA+ D TV+LW SEF HT PV V+F + LA+ S D++I+ W +
Sbjct: 159 GKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
+ + + + VR F+PDG + S +D +++++ ++C
Sbjct: 219 EKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 136 bits (343), Expect = 4e-32
Identities = 75/277 (27%), Positives = 140/277 (50%), Gaps = 11/277 (3%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+T++D++ + +A D+ + +W+ P + SV+ + +L+ S
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D R+ + H+ PV FS D +L ++SED ++++WS+ L
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
H + V +FSP G VS D+ ++W T + Q + F+ + N F+P+
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
Query: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260
+A+ +D+TV++WDV ++ + H G ++ ++F P+G +L T ++DG + + D+ G
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Query: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
++ L+GHT V ++ FS+ GE+ ASG D V LW
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 110 bits (276), Expect = 2e-24
Identities = 58/202 (28%), Positives = 96/202 (47%)
Query: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFL 117
GH V FSP N L S+S D TVRLW +K H PV FS G +
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 118 ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ 177
+ D+ ++W+ + L H V C +F P+ + + S D+T+++WD N
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 178 CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
CV F+ G + + F+P+G +A+ +D V +WD+ ++ + H+ V + F
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 238 PSGNYLITASSDGTLKILDLLE 259
G L + S D T+++ D ++
Sbjct: 721 RDGEILASGSMDNTVRLWDAIK 742
Score = 102 bits (254), Expect = 8e-22
Identities = 54/199 (27%), Positives = 85/199 (42%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
GH + SP+ L ++S D + LW+ + Y GH V QFSP+G
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
S DR RLW D F H A V F + ++AT S D+++++W +
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
+ H + FSP+GR + + + D + +WD + V + F+
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 196 PSGTCIASAGSDQTVKVWD 214
G +AS D TV++WD
Sbjct: 721 RDGEILASGSMDNTVRLWD 739
Score = 96.3 bits (238), Expect = 5e-20
Identities = 51/159 (32%), Positives = 75/159 (47%)
Query: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
+KGH + SP G + D LW + + GH V +F P+ N
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
Query: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
+A+ S DRTVRLW F H P+ S+ FS +G+FLAT + D + +W +
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
+ L HT V +FS DG ++ S S D T+++WD
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 77.4 bits (189), Expect = 3e-14
Identities = 42/118 (35%), Positives = 59/118 (50%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R F GH A + PN +AT S D + LW+ + GHK + S+ FSP+
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
G LA+ + D V LW E K HT V S+ FS DG+ LA+ S D ++++W
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 67.0 bits (162), Expect = 4e-11
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 155 DGRLIVSCSEDKTIKIWDTTNKQC--VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
D LI D T+++W T K+ V SD + I D ++
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDL-------------SLIDKESDDVLERI 527
Query: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP 272
D + L+ HSG V SF P NYL+++S DGT+++ L + +GH P
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
Query: 273 VFTVSFSKGGELFASGGADTQVLLWRTN 300
V+ FS G F SGG D LW T+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATD 615
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 134 bits (336), Expect = 2e-31
Identities = 84/283 (29%), Positives = 137/283 (48%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + G LAT S+D F +W K A HK + +++++ GN + SA
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ ++ F A+ S D I V + + R + +
Sbjct: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRPIKTF 345
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGT- 199
HT+ V K+ P G L+ SCS+D T+KIW CV++ + ++P+G
Sbjct: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405
Query: 200 --------CIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WDV + H V ++F P G YL + S D
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ +G TG +F V ++ G+ + +D V
Sbjct: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSV 507
Score = 115 bits (287), Expect = 1e-25
Identities = 79/308 (25%), Positives = 138/308 (44%), Gaps = 25/308 (8%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA------YRYV---GHKDV--- 62
+GH++ + +P LA+ S D+ +WN ++ + R+ G +DV
Sbjct: 166 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSN 225
Query: 63 --VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
VTS+ ++ G LLA+ S D R+W D S H P+ ++ ++ G F+ +A
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIWTKDGN-LASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
DK+ +W + H+ + + SCS D I + + +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRPIK 343
Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG 240
F N + ++P+G +AS D T+K+W ++ + + Q H+ + I + P+G
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
Query: 241 N---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
L +AS D T+++ D+ G I+TL H PV++V+FS G ASG D
Sbjct: 404 PGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463
Query: 292 TQVLLWRT 299
V +W T
Sbjct: 464 KCVHIWNT 471
Score = 100 bits (248), Expect = 4e-21
Identities = 73/272 (26%), Positives = 120/272 (44%), Gaps = 25/272 (9%)
Query: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKA-------- 100
P +A GH+ V ++P +LLAS S D T R+W + +
Sbjct: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
Query: 101 ------HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
V S+D++++G LAT S D ++W+ +L +H + K++
Sbjct: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNK 276
Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
G I+S DKT IWD + F A VD+ + T AS +D + V
Sbjct: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCK 335
Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
+ ++ ++ +Q H+ VN I + P+GN L + S D TLKI + + ++ LQ H ++
Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
T+ +S G + AS D+ V LW
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLW 427
Score = 94.0 bits (232), Expect = 3e-19
Identities = 60/215 (27%), Positives = 106/215 (49%), Gaps = 11/215 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
GNLLAS S D T+++W + + +AH + ++ +S G LA+AS
Sbjct: 360 TGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASAS 419
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + R +++L +H V FSPDGR + S S DK + IW+T V++
Sbjct: 420 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 479
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
+ + G V +N +G + ++ SD +V V D+R
Sbjct: 480 YRGTGGIFE-VCWNAAGDKVGASASDGSVCVLDLR 513
Score = 57.4 bits (137), Expect = 3e-08
Identities = 34/124 (27%), Positives = 56/124 (45%), Gaps = 15/124 (12%)
Query: 194 FNPSGTCIASAGSDQTVKVWDVRVN------KLLQHYQVHSGG--------VNCISFHPS 239
+NP +AS D T ++W++ N +L+ + + GG V + ++
Sbjct: 177 WNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSE 236
Query: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
G L T S DG +I +G L TL H GP+F + ++K G S G D ++W
Sbjct: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295
Query: 300 NFDE 303
+ E
Sbjct: 296 HTGE 299
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 131 bits (330), Expect = 1e-30
Identities = 85/291 (29%), Positives = 127/291 (43%), Gaps = 9/291 (3%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL- 74
G I+ SPN K LATA W LW+ + GH V ++ F P +
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 75 -------LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
LAS + D +V+LW D ++ + HT V V + G+FL T D+S +
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
+W + Q + H+ V F DG L + D ++WD +C+ +
Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408
Query: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITA 246
++F+P+G IA+ D T KVWD+R + + H V + F P GN+L+T
Sbjct: 409 EIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTG 468
Query: 247 SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
+ D T KI + TL GH G V + S G+L A+ D LW
Sbjct: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 90.5 bits (223), Expect = 3e-18
Identities = 53/210 (25%), Positives = 94/210 (44%), Gaps = 3/210 (1%)
Query: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64
+++PV + +GH + + P+G+ L T +D LW+ + GH V
Sbjct: 312 SDEPVAD--IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVY 369
Query: 65 SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK 124
+ F G+L + D R+W + H + ++FS +G +AT S D
Sbjct: 370 DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDN 429
Query: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183
+ KVW + ++R +Y++ H + V KF P G +++ + D T KIW + +
Sbjct: 430 TCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLA 489
Query: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
G +D + G IA+ D+T K+W
Sbjct: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 46.2 bits (108), Expect = 7e-05
Identities = 30/121 (24%), Positives = 47/121 (38%), Gaps = 43/121 (35%)
Query: 13 YFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP-H 71
+ +GH I ++ SPNG +AT S D +W+ + Y H+++VT V+F P H
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461
Query: 72 GN------------------------------------------LLASASRDRTVRLWIP 89
GN L+A+ S DRT +LW+
Sbjct: 462 GNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
Query: 90 D 90
+
Sbjct: 522 E 522
Score = 36.2 bits (82), Expect = 0.067
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 8/76 (10%)
Query: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG--------PVFTVSFSKGGELFAS 287
F P+ L TA G K+ + + L++TL+GH P TVS AS
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 288 GGADTQVLLWRTNFDE 303
AD V LW + DE
Sbjct: 299 CAADGSVKLWSLDSDE 314
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 130 bits (326), Expect = 3e-30
Identities = 85/286 (29%), Positives = 135/286 (47%), Gaps = 10/286 (3%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
++F H + S SP+G+ L T S D + W + +R GH V +FSP
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
G+L ASAS D TVRLW + K H V +V FS D + LA+ DK + +W +
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD------TTNKQCVNNFSDS 185
+ L L H ++ + FSP + + S D T+ IWD + Q + S +
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
Query: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
+ + + ++ SG +AS D+T+ +W + LL + H V I+F P +L +
Sbjct: 195 I---SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
A +K+ D G+ + TL+G T +F+ G++ SG AD
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 122 bits (305), Expect = 9e-28
Identities = 64/201 (31%), Positives = 99/201 (49%), Gaps = 4/201 (1%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R KGH+ ++ ++ SP+ +QLA+ WD +MLW+ + VGH+D + S FSP
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
Query: 72 GNLLASASRDRTVRLW---IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
N LA+ S D TV +W + + H+A + + +SA G LA+ S DK+I +
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHI 217
Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
W L L H WV+ FSPD + S + +K+WD +C+ +
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 189 ANFVDFNPSGTCIASAGSDQT 209
A+ F P G + S +DQT
Sbjct: 278 AHTCAFTPDGKILVSGAADQT 298
Score = 120 bits (302), Expect = 2e-27
Identities = 79/253 (31%), Positives = 116/253 (45%), Gaps = 5/253 (1%)
Query: 52 RAYRYVG-HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110
R ++ G H V S FSP G +L + S D V W HT PV+ F
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
Query: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKI 170
S DG A+AS D ++++W + R + L L H V FSPD R + S DK + +
Sbjct: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
Query: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR-VNKLLQHYQV--H 227
WD + Q + DF+P+ C+A+ D TV +WD+R V + H + H
Sbjct: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
Query: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFAS 287
S ++C+ + SG L + S D T+ I L+ L+GH V +++FS AS
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 288 GGADTQVLLWRTN 300
G V +W N
Sbjct: 251 AGYSRMVKVWDCN 263
Score = 115 bits (287), Expect = 1e-25
Identities = 73/220 (33%), Positives = 105/220 (47%), Gaps = 12/220 (5%)
Query: 91 KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150
+R KF F H V S FS DGQ L T SED + W + L+ L HT V+
Sbjct: 12 RRVKF--FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC 69
Query: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
+FSPDG L S S D T+++WD +C+ V F+P +AS G D+ V
Sbjct: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
Query: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI------Y 264
+WDV+ ++L+ H + F P+ N L T S D T+ I DL R++
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL---RMVTPAVSHQ 186
Query: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
L+GH+ + + +S G L ASG D + +W+ L
Sbjct: 187 ALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL 225
Score = 90.9 bits (224), Expect = 2e-18
Identities = 54/168 (32%), Positives = 85/168 (50%), Gaps = 4/168 (2%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK---PHARAYRYVGHKDVVTSVQF 68
R GH+ +I S D SP LAT SWD+ + +W+ + P GH ++ + +
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
Query: 69 SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
S G LLAS S D+T+ +W P + K H V+S+ FS D +LA+A + +KV
Sbjct: 201 SASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
W + L +L F+PDG+++VS + D+T + T+K
Sbjct: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 129 bits (324), Expect = 6e-30
Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + NG LAT S+D F +W + A HK + +++++ GN + SA
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + R + +
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 357
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW + C+++ + ++P+G
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WD+ H V ++F P G YL + S D
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ +G TG +F V ++ G+ + +D V
Sbjct: 478 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 519
Score = 114 bits (284), Expect = 3e-25
Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ +G LLA+ S D R+W D S H P+ ++ ++ G ++ +
Sbjct: 238 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 295
Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
A DK+ +W + +Q+F + + W F+ SCS D I +
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348
Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
+ V F N + ++PSG +AS D T+K+W ++ + Q H+ +
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408
Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
I + P+G L +AS D T+++ D+ G +TL H PV++V+FS G+
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468
Query: 285 FASGGADTQVLLWRTNFDEL 304
ASG D V +W T L
Sbjct: 469 LASGSFDKCVHIWNTQSGNL 488
Score = 99.0 bits (245), Expect = 8e-21
Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)
Query: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
P ++A GH+ V ++P +LLAS S D T R+W ++ +
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229
Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
H P V S+D++ +G LAT S D ++W+ +L +H + K++
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 288
Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
G I+S DKT IWD + F A VD+ + T AS +D + V
Sbjct: 289 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 347
Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
+ ++ ++ +Q H+ VN I + PSG L + S D TLKI + + I+ LQ H ++
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407
Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
T+ +S G + AS D+ V LW
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Score = 89.0 bits (219), Expect = 9e-18
Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 313 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH + ++ +S G LA+AS
Sbjct: 372 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + R ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
+ + G V +N G + ++ SD +V V D+R
Sbjct: 492 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 525
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 211
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 129 bits (324), Expect = 6e-30
Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + NG LAT S+D F +W + A HK + +++++ GN + SA
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + R + +
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 357
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW + C+++ + ++P+G
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WD+ H V ++F P G YL + S D
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ +G TG +F V ++ G+ + +D V
Sbjct: 478 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 519
Score = 114 bits (284), Expect = 3e-25
Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ +G LLA+ S D R+W D S H P+ ++ ++ G ++ +
Sbjct: 238 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 295
Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
A DK+ +W + +Q+F + + W F+ SCS D I +
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348
Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
+ V F N + ++PSG +AS D T+K+W ++ + Q H+ +
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408
Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
I + P+G L +AS D T+++ D+ G +TL H PV++V+FS G+
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468
Query: 285 FASGGADTQVLLWRTNFDEL 304
ASG D V +W T L
Sbjct: 469 LASGSFDKCVHIWNTQSGNL 488
Score = 99.0 bits (245), Expect = 8e-21
Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)
Query: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
P ++A GH+ V ++P +LLAS S D T R+W ++ +
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229
Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
H P V S+D++ +G LAT S D ++W+ +L +H + K++
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 288
Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
G I+S DKT IWD + F A VD+ + T AS +D + V
Sbjct: 289 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 347
Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
+ ++ ++ +Q H+ VN I + PSG L + S D TLKI + + I+ LQ H ++
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407
Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
T+ +S G + AS D+ V LW
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Score = 89.0 bits (219), Expect = 9e-18
Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 313 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH + ++ +S G LA+AS
Sbjct: 372 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 431
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + R ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 432 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 491
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
+ + G V +N G + ++ SD +V V D+R
Sbjct: 492 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 525
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 211
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 129 bits (324), Expect = 6e-30
Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + NG LAT S+D F +W + A HK + +++++ GN + SA
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + R + +
Sbjct: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 408
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW + C+++ + ++P+G
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WD+ H V ++F P G YL + S D
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ +G TG +F V ++ G+ + +D V
Sbjct: 529 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570
Score = 114 bits (284), Expect = 3e-25
Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ +G LLA+ S D R+W D S H P+ ++ ++ G ++ +
Sbjct: 289 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 346
Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
A DK+ +W + +Q+F + + W F+ SCS D I +
Sbjct: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
+ V F N + ++PSG +AS D T+K+W ++ + Q H+ +
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
I + P+G L +AS D T+++ D+ G +TL H PV++V+FS G+
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
Query: 285 FASGGADTQVLLWRTNFDEL 304
ASG D V +W T L
Sbjct: 520 LASGSFDKCVHIWNTQSGNL 539
Score = 99.0 bits (245), Expect = 8e-21
Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)
Query: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
P ++A GH+ V ++P +LLAS S D T R+W ++ +
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
H P V S+D++ +G LAT S D ++W+ +L +H + K++
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 339
Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
G I+S DKT IWD + F A VD+ + T AS +D + V
Sbjct: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
+ ++ ++ +Q H+ VN I + PSG L + S D TLKI + + I+ LQ H ++
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
T+ +S G + AS D+ V LW
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490
Score = 89.0 bits (219), Expect = 9e-18
Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 364 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH + ++ +S G LA+AS
Sbjct: 423 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + R ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
+ + G V +N G + ++ SD +V V D+R
Sbjct: 543 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 576
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 262
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 129 bits (324), Expect = 6e-30
Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + NG LAT S+D F +W + A HK + +++++ GN + SA
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + R + +
Sbjct: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 408
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW + C+++ + ++P+G
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WD+ H V ++F P G YL + S D
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ +G TG +F V ++ G+ + +D V
Sbjct: 529 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570
Score = 114 bits (284), Expect = 3e-25
Identities = 84/320 (26%), Positives = 142/320 (44%), Gaps = 39/320 (12%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ +G LLA+ S D R+W D S H P+ ++ ++ G ++ +
Sbjct: 289 KDV-TSLDWNTNGTLLATGSYDGFARIWTEDGN-LASTLGQHKGPIFALKWNRKGNYILS 346
Query: 120 ASEDKSIKVWSMY----RQRFLY--SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
A DK+ +W + +Q+F + + W F+ SCS D I +
Sbjct: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
+ V F N + ++PSG +AS D T+K+W ++ + Q H+ +
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
Query: 234 ISFHPSGN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
I + P+G L +AS D T+++ D+ G +TL H PV++V+FS G+
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
Query: 285 FASGGADTQVLLWRTNFDEL 304
ASG D V +W T L
Sbjct: 520 LASGSFDKCVHIWNTQSGNL 539
Score = 99.0 bits (245), Expect = 8e-21
Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 25/272 (9%)
Query: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
P ++A GH+ V ++P +LLAS S D T R+W ++ +
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
Query: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
H P V S+D++ +G LAT S D ++W+ +L +H + K++
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 339
Query: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
G I+S DKT IWD + F A VD+ + T AS +D + V
Sbjct: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
Query: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
+ ++ ++ +Q H+ VN I + PSG L + S D TLKI + + I+ LQ H ++
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
Query: 275 TVSFSKGGE---------LFASGGADTQVLLW 297
T+ +S G + AS D+ V LW
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490
Score = 89.0 bits (219), Expect = 9e-18
Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 364 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH + ++ +S G LA+AS
Sbjct: 423 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + R ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
+ + G V +N G + ++ SD +V V D+R
Sbjct: 543 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 576
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 262
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 129 bits (324), Expect = 6e-30
Identities = 93/333 (27%), Positives = 149/333 (44%), Gaps = 50/333 (15%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSP-HG 72
KGH+ + S+ SP+G++LA+ + ++LW+ + R + GH +T + + P H
Sbjct: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212
Query: 73 N----LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
N +AS+S+D +VR+W HT V + + DG L +AS+D++IKV
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271
Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRL------------------------------ 158
W + +L H HWV S D L
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331
Query: 159 ------------IVSCSEDKTIKIWDTT-NKQCVNNFSDSVGFANFVDFNPSGTCIASAG 205
+VS S+D T+ +W +K+ + + N V F+P +ASA
Sbjct: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391
Query: 206 SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
D+++K+WD R K L + H V I++ L++ SSD TLK+ D+ +L
Sbjct: 392 FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD 451
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
L GH V+ V +S G+ ASGG D + +WR
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 112 bits (281), Expect = 6e-25
Identities = 89/375 (23%), Positives = 157/375 (41%), Gaps = 63/375 (16%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
+GH A+ S+ SP GK LA+ S DT + W+ + GH+ V S+ +SP G
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 75 LASASRDRTVRLWIPDKRGKFSEFKA-HTAPVRSVDF-----SADGQFLATASEDKSIKV 128
LAS ++ + LW P + A H+ + + + + + +++A++S+D S+++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
Query: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK----------QC 178
W R L HT V C ++ DG L+ S S+D+TIK+W +
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289
Query: 179 VNNFSDSVGFANFVD-FNPSGTCI-------------------------------ASAGS 206
VN + S +A F P+ + S
Sbjct: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
Query: 207 DQTVKVWDVRVNKL-LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
D T+ +W +K L H +N + F P + +AS D ++K+ D G+ + +
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHL 325
L+GH V+ +++S L SG +D+ + +W ++L D P H
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV-------------KAQKLAMDLPGHA 456
Query: 326 LDIYPRTPHPHEEKV 340
++Y P ++V
Sbjct: 457 DEVYAVDWSPDGQRV 471
Score = 92.8 bits (229), Expect = 6e-19
Identities = 66/231 (28%), Positives = 109/231 (47%), Gaps = 11/231 (4%)
Query: 96 SEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD 155
S + H+ V SV FS G++LA+ S D +++ W + + ++ H HWV +SPD
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
Query: 156 GRLIVSCSEDKTIKIWD-TTNKQCVNNFSDSVGFANFVDF-----NPSGTCIASAGSDQT 209
GR + S ++ I +WD +T KQ + + + + NP +AS+ D +
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
Query: 210 VKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH 269
V++WD + + H+ V C+ + G L +AS D T+K+ +G L TLQGH
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 286
Query: 270 TGPVFTVSFSKGGEL----FASGGADTQVLLWRTNFDELHCKGLTKRNLKR 316
V T++ S L F A + + EL + L++ NL R
Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337
Score = 68.9 bits (167), Expect = 9e-12
Identities = 38/127 (29%), Positives = 63/127 (49%)
Query: 3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV 62
S ED GH+A I + SP+ + +A+AS+D + LW+ + GH
Sbjct: 357 SPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAA 416
Query: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
V + +S LL S S D T+++W + + H V +VD+S DGQ +A+ +
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 476
Query: 123 DKSIKVW 129
DK +++W
Sbjct: 477 DKCLRIW 483
Score = 53.5 bits (127), Expect = 4e-07
Identities = 28/81 (34%), Positives = 43/81 (53%)
Query: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV 276
V + + HS V ++F P+G YL + S D T++ DL +T +GH V ++
Sbjct: 103 VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSI 162
Query: 277 SFSKGGELFASGGADTQVLLW 297
S+S G ASG + Q+LLW
Sbjct: 163 SWSPDGRKLASGCKNGQILLW 183
Score = 38.9 bits (89), Expect = 0.010
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Query: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELH--CKG 308
R +L+GH+ V +V+FS G+ ASG DT V W + + H CKG
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKG 154
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 125 bits (314), Expect = 8e-29
Identities = 80/304 (26%), Positives = 144/304 (47%), Gaps = 13/304 (4%)
Query: 3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKD 61
S+ + P++ GH+ + PNG LA+A +D ++LWN Y + GH
Sbjct: 53 SSLQAPIM--LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110
Query: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG-QFLATA 120
V + ++ G++L SAS D+TV +W + + K HT+ V S + G Q + T
Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170
Query: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
S+D ++K+W + R++ +++T+ V F+ I+S D IK+WD +
Sbjct: 171 SDDGTVKLWDI-RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
Query: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQ--VHSGGVNCI 234
+ + G+ + S D TV+VWDVR + ++ +Q VH+ N +
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
Query: 235 --SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
S+ P G+ + S+D + + D R++Y L GH G + V+F + S +D
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
Query: 293 QVLL 296
++ +
Sbjct: 350 RLYM 353
Score = 124 bits (312), Expect = 1e-28
Identities = 86/308 (27%), Positives = 143/308 (46%), Gaps = 24/308 (7%)
Query: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
GH+ V +F P+G+ LASA DR + LW + ++ K H+ V + ++ DG
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVR-CAKFSPDGRLIVSCSEDKTIKIWDTTN 175
L +AS DK++ VW + L HT +V C +L+ + S+D T+K+WD
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
Query: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
K + F ++ V FN + I S G D +KVWD+R NKL + H+ V +S
Sbjct: 184 KAAIQTFQNTYQVLA-VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
Query: 236 FHPSGNYLITASSDGTLKILDLL----EGRLIYTLQGHTGP----VFTVSFSKGGELFAS 287
G+YL++ + D T+++ D+ + R + QG+ + S+S G A+
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
Query: 288 GGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINP 347
G AD V +W T +R+ + P H I HP E + + +
Sbjct: 303 GSADRFVYVWDT-------------TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
Query: 348 KLEVIDLQ 355
+L + ++Q
Sbjct: 350 RLYMGEIQ 357
Score = 82.8 bits (203), Expect = 6e-16
Identities = 63/253 (24%), Positives = 103/253 (40%), Gaps = 52/253 (20%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG-N 73
KGH A+ L + +G L +AS D + +W+ + R R GH V S + G
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
Query: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
L+ + S D TV+LW K+ F+ +T V +V F+ + + D IKVW + +
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
Query: 134 QRFLYSLYRHTHWV---------------------------------RCAK--------- 151
+ Y++ H V RC K
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
Query: 152 --------FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIAS 203
+SPDG I + S D+ + +WDTT+++ + G N V F+P I S
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIIS 344
Query: 204 AGSDQTVKVWDVR 216
A SD+ + + +++
Sbjct: 345 ASSDKRLYMGEIQ 357
Score = 33.9 bits (76), Expect = 0.33
Identities = 16/40 (40%), Positives = 18/40 (45%)
Query: 263 IYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
I L GH G V+ F G AS G D +LLW D
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD 98
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 125 bits (314), Expect = 8e-29
Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + +G LA S+D F +W + A HK + +++++ GN + SA
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + + +
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW CV++ + ++P+G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WDV H V ++F P G YL + S D
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ QG TG +F V ++ G+ + +D V
Sbjct: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517
Score = 113 bits (282), Expect = 4e-25
Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ G LLA S D R+W + S H P+ ++ ++ G ++ +
Sbjct: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
A DK+ +W + H+ + + SCS D I + V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
F N + ++PSG +AS D T+K+W ++ + + Q HS + I + P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
G L +AS D T+++ D+ +G +TL H PV++V+FS G+ ASG
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472
Query: 291 DTQVLLWRTNFDEL 304
D V +W T L
Sbjct: 473 DKYVHIWNTQSGSL 486
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH+ + ++ +S G LA+AS
Sbjct: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + + ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
+ + G V +N G + ++ SD +V V D+
Sbjct: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 125 bits (314), Expect = 8e-29
Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + +G LA S+D F +W + A HK + +++++ GN + SA
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + + +
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW CV++ + ++P+G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WDV H V ++F P G YL + S D
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ QG TG +F V ++ G+ + +D V
Sbjct: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517
Score = 113 bits (282), Expect = 4e-25
Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ G LLA S D R+W + S H P+ ++ ++ G ++ +
Sbjct: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
A DK+ +W + H+ + + SCS D I + V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
F N + ++PSG +AS D T+K+W ++ + + Q HS + I + P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
G L +AS D T+++ D+ +G +TL H PV++V+FS G+ ASG
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472
Query: 291 DTQVLLWRTNFDEL 304
D V +W T L
Sbjct: 473 DKYVHIWNTQSGSL 486
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH+ + ++ +S G LA+AS
Sbjct: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + + ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
+ + G V +N G + ++ SD +V V D+
Sbjct: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 125 bits (314), Expect = 8e-29
Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 12/283 (4%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
+TSLD + +G LA S+D F +W + A HK + +++++ GN + SA
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL-ASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
D+T +W +F H+AP VD+ + F A+ S D I V + + +
Sbjct: 297 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHPVKTF 355
Query: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
HT+ V K+ P G L+ SCS+D T+KIW CV++ + ++P+G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
Query: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
+ASA D TV++WDV H V ++F P G YL + S D
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Query: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
+ I + G L+++ QG TG +F V ++ G+ + +D V
Sbjct: 476 VHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSV 517
Score = 113 bits (282), Expect = 4e-25
Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 27/314 (8%)
Query: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARA----------YRYVGH----- 59
+GH++ + +P LA+ S D+ +WN ++ R GH
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
KDV TS+ ++ G LLA S D R+W + S H P+ ++ ++ G ++ +
Sbjct: 236 KDV-TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
A DK+ +W + H+ + + SCS D I + V
Sbjct: 294 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
F N + ++PSG +AS D T+K+W ++ + + Q HS + I + P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 240 GN---------YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
G L +AS D T+++ D+ +G +TL H PV++V+FS G+ ASG
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSF 472
Query: 291 DTQVLLWRTNFDEL 304
D V +W T L
Sbjct: 473 DKYVHIWNTQSGSL 486
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 11/214 (5%)
Query: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 311 KQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP 369
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
G LLAS S D T+++W + + +AH+ + ++ +S G LA+AS
Sbjct: 370 SGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASAS 429
Query: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
D ++++W + + ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 430 FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489
Query: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
+ + G V +N G + ++ SD +V V D+
Sbjct: 490 YQGTGGIFE-VCWNARGDKVGASASDGSVCVLDL 522
Score = 30.0 bits (66), Expect = 4.8
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
L+GH VF +++ +L ASG D+ +W N
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLN 209
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 117 bits (292), Expect = 3e-26
Identities = 60/165 (36%), Positives = 85/165 (51%)
Query: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
++GH + LD+SP A+ S D LW+F Y GH V V+F P+ N
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
Query: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
LA+ S D+TVRLW + F H PV S+ FS +G++LA+A ED+ +K+W +
Sbjct: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
Query: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
L HT + FSPD LI S S D ++++WD N C
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
Score = 109 bits (273), Expect = 5e-24
Identities = 73/287 (25%), Positives = 133/287 (46%), Gaps = 16/287 (5%)
Query: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
F + + + ++SP+ K LA ++ + LW+ + ++ + H+ V+ + + +
Sbjct: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLR--SKKLKSEPHQVDVSRIHLAC--D 319
Query: 74 LLASASRDRTVRLWIPDKRG-KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM- 131
+L + D G + + H PV S F AD L + SED SI+ W +
Sbjct: 320 ILEEEDDE-------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLG 372
Query: 132 -YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
+ LY + + W SP S S D+T ++W + ++ + +
Sbjct: 373 SFTNTVLYQGHAYPVWD--LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430
Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
V F+P+ +A+ +D+TV++W + ++ + H G V ++F P+G YL +A D
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
LK+ DL G L L+GHT + +++FS L AS D V +W
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 109 bits (272), Expect = 6e-24
Identities = 60/205 (29%), Positives = 91/205 (44%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
+ +GH + S + L + S D + W+ Y GH V + SP+
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
AS S DRT RLW D+ + H A V V F + +LAT S DK++++WS
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
+ + H V FSP+G+ + S ED+ +K+WD +
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
Query: 192 VDFNPSGTCIASAGSDQTVKVWDVR 216
+ F+P IASA D +V+VWD+R
Sbjct: 516 LTFSPDSGLIASASMDNSVRVWDIR 540
Score = 106 bits (265), Expect = 4e-23
Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 6/203 (2%)
Query: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE---FKAHTAPVRSVDFSADG 114
GH V S +F + L S S D ++R W G F+ ++ H PV +D S
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYW---DLGSFTNTVLYQGHAYPVWDLDISPYS 396
Query: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
+ A+ S D++ ++WS R L H V C KF P+ + + S DKT+++W
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ 456
Query: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 234
V F+ G + F+P+G +ASAG DQ +K+WD+ L + + H+ + +
Sbjct: 457 QGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSL 516
Query: 235 SFHPSGNYLITASSDGTLKILDL 257
+F P + +AS D ++++ D+
Sbjct: 517 TFSPDSGLIASASMDNSVRVWDI 539
Score = 43.5 bits (101), Expect = 4e-04
Identities = 40/170 (23%), Positives = 68/170 (40%), Gaps = 16/170 (9%)
Query: 138 YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPS 197
Y+ Y + A+ SPD +L+ + ++ IK+W +K+ + + VD +
Sbjct: 262 YAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE-------PHQVDVSRI 314
Query: 198 GTC--IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL 255
I D+ D ++ + H G V F + L++ S D +++
Sbjct: 315 HLACDILEEEDDE-----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYW 369
Query: 256 DLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELH 305
DL QGH PV+ + S FASG D LW +FD +
Sbjct: 370 DLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLW--SFDRTY 417
Score = 32.0 bits (71), Expect = 1.3
Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 10/58 (17%)
Query: 1 MASATEDPVLERY----------FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK 48
+ASA ED L+ + +GH ITSL SP+ +A+AS D + +W+ +
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 116 bits (290), Expect = 5e-26
Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 16/248 (6%)
Query: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH----TAPVRSVDFSADG 114
H V +VQFSP LLA+ DR V+LW + G+ EFK A + S++F + G
Sbjct: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFDSAG 378
Query: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
+L AS D + ++W++ R ++L H+ V AKF D IVS S D+T+K+WD
Sbjct: 379 SYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR 438
Query: 175 NKQCVNN-FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
+K C+ F+ S + D + C+ S D+ ++ WD+R +++ ++ G +
Sbjct: 439 SKVCIKTVFAGS----SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKITA 493
Query: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG---HTGPVFT-VSFSKGGELFASGG 289
+ +P L++ S D LK++DL + T G +T V FS G A+G
Sbjct: 494 LDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGS 553
Query: 290 ADTQVLLW 297
A+ + +W
Sbjct: 554 AEGSLYIW 561
Score = 81.3 bits (199), Expect = 2e-15
Identities = 62/238 (26%), Positives = 105/238 (44%), Gaps = 15/238 (6%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
G A ITS++ G L AS D +W + + GH V S +F +
Sbjct: 364 GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARI 423
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
S S DRT++LW D R K K A D Q + + DK I+ W + R
Sbjct: 424 VSGSHDRTLKLW--DLRSKVC-IKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI-RSE 479
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-----N 190
+ + +P+ ++SCS D +K+ D FS + GF
Sbjct: 480 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS-APGFKCGSDWT 538
Query: 191 FVDFNPSGTCIASAGSDQTVKVWDV---RVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
V F+P G+ +A+ ++ ++ +W V +V K+L + HS +N +++ PSG+++++
Sbjct: 539 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLS--KQHSSSINAVAWSPSGSHVVS 594
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHA--RAYRYVGHK--DVVTSVQFSPHGNLLA 76
IT+LDL+P +L + S D L + + + +A + + G K T V FSP G+ +A
Sbjct: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550
Query: 77 SASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
+ S + ++ +W GK + K H++ + +V +S G + + + +W+ Y
Sbjct: 551 AGSAEGSLYIWSV-LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQY 607
Score = 41.2 bits (95), Expect = 0.002
Identities = 46/220 (20%), Positives = 84/220 (38%), Gaps = 23/220 (10%)
Query: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHA---RAYRYVGHKDV 62
+D L GH + S + ++ + S D L LW+ + + D+
Sbjct: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDI 455
Query: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
V + Q G+ D+ +R W E + + ++D + + L + S
Sbjct: 456 VCTEQCVMSGHF------DKKIRFWDIRSESIVREMEL-LGKITALDLNPERTELLSCSR 508
Query: 123 DKSIKVWSM----YRQRFLYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT---- 173
D +KV + +Q F ++ + W R FSPDG + + S + ++ IW
Sbjct: 509 DDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGK 567
Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
K S S+ N V ++PSG+ + S +W
Sbjct: 568 VEKVLSKQHSSSI---NAVAWSPSGSHVVSVDKGCKAVLW 604
Score = 39.3 bits (90), Expect = 0.008
Identities = 42/185 (22%), Positives = 64/185 (34%), Gaps = 60/185 (32%)
Query: 224 YQVHSGGVNCISFHP--------------------------------------------S 239
+ H G VN + F P +
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377
Query: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW-- 297
G+YL+ AS+D +I + + RL +TL GH+G V + F SG D + LW
Sbjct: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
Query: 298 ------RTNFDELHCKGL--TKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKL 349
+T F C + T++ + HFD DI E V +E+ K+
Sbjct: 438 RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI------RSESIVREMELLGKI 491
Query: 350 EVIDL 354
+DL
Sbjct: 492 TALDL 496
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 116 bits (290), Expect = 5e-26
Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 16/248 (6%)
Query: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH----TAPVRSVDFSADG 114
H V +VQFSP LLA+ DR V+LW + G+ EFK A + S++F + G
Sbjct: 302 HDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFDSAG 359
Query: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
+L AS D + ++W++ R ++L H+ V AKF D IVS S D+T+K+WD
Sbjct: 360 SYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR 419
Query: 175 NKQCVNN-FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
+K C+ F+ S + D + C+ S D+ ++ WD+R +++ ++ G +
Sbjct: 420 SKVCIKTVFAGS----SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKITA 474
Query: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG---HTGPVFT-VSFSKGGELFASGG 289
+ +P L++ S D LK++DL + T G +T V FS G A+G
Sbjct: 475 LDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGS 534
Query: 290 ADTQVLLW 297
A+ + +W
Sbjct: 535 AEGSLYIW 542
Score = 81.3 bits (199), Expect = 2e-15
Identities = 62/238 (26%), Positives = 105/238 (44%), Gaps = 15/238 (6%)
Query: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
G A ITS++ G L AS D +W + + GH V S +F +
Sbjct: 345 GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARI 404
Query: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
S S DRT++LW D R K K A D Q + + DK I+ W + R
Sbjct: 405 VSGSHDRTLKLW--DLRSKVC-IKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI-RSE 460
Query: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-----N 190
+ + +P+ ++SCS D +K+ D FS + GF
Sbjct: 461 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS-APGFKCGSDWT 519
Query: 191 FVDFNPSGTCIASAGSDQTVKVWDV---RVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
V F+P G+ +A+ ++ ++ +W V +V K+L + HS +N +++ PSG+++++
Sbjct: 520 RVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLS--KQHSSSINAVAWSPSGSHVVS 575
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHA--RAYRYVGHK--DVVTSVQFSPHGNLLA 76
IT+LDL+P +L + S D L + + + +A + + G K T V FSP G+ +A
Sbjct: 472 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 531
Query: 77 SASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
+ S + ++ +W GK + K H++ + +V +S G + + + +W+ Y
Sbjct: 532 AGSAEGSLYIWSV-LTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQY 588
Score = 41.2 bits (95), Expect = 0.002
Identities = 46/220 (20%), Positives = 84/220 (38%), Gaps = 23/220 (10%)
Query: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHA---RAYRYVGHKDV 62
+D L GH + S + ++ + S D L LW+ + + D+
Sbjct: 377 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDI 436
Query: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
V + Q G+ D+ +R W E + + ++D + + L + S
Sbjct: 437 VCTEQCVMSGHF------DKKIRFWDIRSESIVREMEL-LGKITALDLNPERTELLSCSR 489
Query: 123 DKSIKVWSM----YRQRFLYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT---- 173
D +KV + +Q F ++ + W R FSPDG + + S + ++ IW
Sbjct: 490 DDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGK 548
Query: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
K S S+ N V ++PSG+ + S +W
Sbjct: 549 VEKVLSKQHSSSI---NAVAWSPSGSHVVSVDKGCKAVLW 585
Score = 39.3 bits (90), Expect = 0.008
Identities = 42/185 (22%), Positives = 64/185 (34%), Gaps = 60/185 (32%)
Query: 224 YQVHSGGVNCISFHP--------------------------------------------S 239
+ H G VN + F P +
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 358
Query: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW-- 297
G+YL+ AS+D +I + + RL +TL GH+G V + F SG D + LW
Sbjct: 359 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 418
Query: 298 ------RTNFDELHCKGL--TKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKL 349
+T F C + T++ + HFD DI E V +E+ K+
Sbjct: 419 RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDI------RSESIVREMELLGKI 472
Query: 350 EVIDL 354
+DL
Sbjct: 473 TALDL 477
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 114 bits (284), Expect = 3e-25
Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R GH + S + N + + S D L +WN + + GH V + H
Sbjct: 297 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 352
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
+ S SRD T+R+W + H A VR V + DG+ + + + D +KVW
Sbjct: 353 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 410
Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
+ L++L HT+ V +F DG +VS S D +I++WD C++ + +
Sbjct: 411 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468
Query: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
++ + + S +D TVK+WD++ + LQ Q H V C+ F+ N++IT+S
Sbjct: 469 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 524
Query: 249 DGTLKILDLLEGRLIYTL 266
DGT+K+ DL G I L
Sbjct: 525 DGTVKLWDLKTGEFIRNL 542
Score = 105 bits (262), Expect = 9e-23
Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)
Query: 58 GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
GH D V+T +QF GN + S S D T+++W HT V S +
Sbjct: 260 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 315
Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
+ + S D+++KVW+ +++LY HT VRC + +VS S D T+++WD
Sbjct: 316 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 373
Query: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
QC++ V V ++ G + S D VKVWD L Q H+ V + F
Sbjct: 374 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 431
Query: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
G ++++ S D ++++ D+ G I+TL GH T + SG AD+ V +
Sbjct: 432 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 487
Query: 297 W 297
W
Sbjct: 488 W 488
Score = 103 bits (257), Expect = 3e-22
Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)
Query: 12 RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
+ KGH IT L G ++ + S D L +W+ VGH V S Q
Sbjct: 256 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 311
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
N++ S S DRT+++W + HT+ VR + + + + S D +++VW
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 369
Query: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
+ + L+ L H VRC ++ DGR +VS + D +K+WD + C++
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427
Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
+ F+ G + S D +++VWDV ++ L H + SG N L++
Sbjct: 428 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 479
Query: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
++D T+KI D+ G+ + TLQG H V + F+K + +S D V LW
Sbjct: 480 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 531
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
+++ K+L+ + H + C+ F GN +++ S D TLK+ + G+ + TL GHTG V
Sbjct: 251 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 306
Query: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
+ S + SG D + +W E
Sbjct: 307 W--SSQMRDNIIISGSTDRTLKVWNAETGE 334
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 114 bits (284), Expect = 3e-25
Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R GH + S + N + + S D L +WN + + GH V + H
Sbjct: 415 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 470
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
+ S SRD T+R+W + H A VR V + DG+ + + + D +KVW
Sbjct: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528
Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
+ L++L HT+ V +F DG +VS S D +I++WD C++ + +
Sbjct: 529 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
Query: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
++ + + S +D TVK+WD++ + LQ Q H V C+ F+ N++IT+S
Sbjct: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 642
Query: 249 DGTLKILDLLEGRLIYTL 266
DGT+K+ DL G I L
Sbjct: 643 DGTVKLWDLKTGEFIRNL 660
Score = 105 bits (262), Expect = 9e-23
Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)
Query: 58 GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
GH D V+T +QF GN + S S D T+++W HT V S +
Sbjct: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433
Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
+ + S D+++KVW+ +++LY HT VRC + +VS S D T+++WD
Sbjct: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491
Query: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
QC++ V V ++ G + S D VKVWD L Q H+ V + F
Sbjct: 492 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
G ++++ S D ++++ D+ G I+TL GH T + SG AD+ V +
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 605
Query: 297 W 297
W
Sbjct: 606 W 606
Score = 103 bits (257), Expect = 3e-22
Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)
Query: 12 RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
+ KGH IT L G ++ + S D L +W+ VGH V S Q
Sbjct: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 429
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
N++ S S DRT+++W + HT+ VR + + + + S D +++VW
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487
Query: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
+ + L+ L H VRC ++ DGR +VS + D +K+WD + C++
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
+ F+ G + S D +++VWDV ++ L H + SG N L++
Sbjct: 546 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 597
Query: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
++D T+KI D+ G+ + TLQG H V + F+K + +S D V LW
Sbjct: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 649
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
+++ K+L+ + H + C+ F GN +++ S D TLK+ + G+ + TL GHTG V
Sbjct: 369 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424
Query: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
+ S + SG D + +W E
Sbjct: 425 W--SSQMRDNIIISGSTDRTLKVWNAETGE 452
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 114 bits (284), Expect = 3e-25
Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
R GH + S + N + + S D L +WN + + GH V + H
Sbjct: 335 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 390
Query: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
+ S SRD T+R+W + H A VR V + DG+ + + + D +KVW
Sbjct: 391 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 448
Query: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
+ L++L HT+ V +F DG +VS S D +I++WD C++ + +
Sbjct: 449 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506
Query: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
++ + + S +D TVK+WD++ + LQ Q H V C+ F+ N++IT+S
Sbjct: 507 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 562
Query: 249 DGTLKILDLLEGRLIYTL 266
DGT+K+ DL G I L
Sbjct: 563 DGTVKLWDLKTGEFIRNL 580
Score = 105 bits (262), Expect = 9e-23
Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)
Query: 58 GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
GH D V+T +QF GN + S S D T+++W HT V S +
Sbjct: 298 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 353
Query: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
+ + S D+++KVW+ +++LY HT VRC + +VS S D T+++WD
Sbjct: 354 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 411
Query: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
QC++ V V ++ G + S D VKVWD L Q H+ V + F
Sbjct: 412 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469
Query: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
G ++++ S D ++++ D+ G I+TL GH T + SG AD+ V +
Sbjct: 470 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 525
Query: 297 W 297
W
Sbjct: 526 W 526
Score = 103 bits (257), Expect = 3e-22
Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)
Query: 12 RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
+ KGH IT L G ++ + S D L +W+ VGH V S Q
Sbjct: 294 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 349
Query: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
N++ S S DRT+++W + HT+ VR + + + + S D +++VW
Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 407
Query: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
+ + L+ L H VRC ++ DGR +VS + D +K+WD + C++
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465
Query: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
+ F+ G + S D +++VWDV ++ L H + SG N L++
Sbjct: 466 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 517
Query: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
++D T+KI D+ G+ + TLQG H V + F+K + +S D V LW
Sbjct: 518 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 569
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
+++ K+L+ + H + C+ F GN +++ S D TLK+ + G+ + TL GHTG V
Sbjct: 289 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 344
Query: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
+ S + SG D + +W E
Sbjct: 345 W--SSQMRDNIIISGSTDRTLKVWNAETGE 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,120,255
Number of Sequences: 37866
Number of extensions: 866798
Number of successful extensions: 7142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 283
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 2423
Number of HSP's gapped (non-prelim): 1910
length of query: 478
length of database: 18,247,518
effective HSP length: 106
effective length of query: 372
effective length of database: 14,233,722
effective search space: 5294944584
effective search space used: 5294944584
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.