BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|26190608 synaptojanin 2 [Homo sapiens] (1496 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|26190608 synaptojanin 2 [Homo sapiens] 3025 0.0 gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 1187 0.0 gi|237757308 synaptojanin 1 isoform b [Homo sapiens] 1175 0.0 gi|237757310 synaptojanin 1 isoform a [Homo sapiens] 1174 0.0 gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 1171 0.0 gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso... 223 1e-57 gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso... 223 1e-57 gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs... 206 1e-52 gi|190014578 suppressor of actin 1 [Homo sapiens] 190 1e-47 gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens] 179 1e-44 gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas... 179 2e-44 gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 155 2e-37 gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 155 2e-37 gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 153 1e-36 gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens] 139 2e-32 gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho... 129 3e-29 gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H... 123 2e-27 gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho... 123 2e-27 gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo sa... 105 3e-22 gi|47132519 Ras association and pleckstrin homology domains 1 is... 69 4e-11 gi|153792074 proline rich 12 [Homo sapiens] 67 1e-10 gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 67 1e-10 gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 67 1e-10 gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 67 1e-10 gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 67 1e-10 gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 65 5e-10 gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 64 8e-10 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 62 4e-09 gi|110349719 titin isoform N2-A [Homo sapiens] 60 1e-08 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 60 1e-08 >gi|26190608 synaptojanin 2 [Homo sapiens] Length = 1496 Score = 3025 bits (7843), Expect = 0.0 Identities = 1496/1496 (100%), Positives = 1496/1496 (100%) Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA Sbjct: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60 Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL Sbjct: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120 Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW Sbjct: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180 Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY Sbjct: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240 Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV Sbjct: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300 Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH Sbjct: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360 Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 420 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV Sbjct: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 420 Query: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 480 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA Sbjct: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 480 Query: 481 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 540 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN Sbjct: 481 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 540 Query: 541 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 600 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS Sbjct: 541 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 600 Query: 601 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 660 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG Sbjct: 601 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 660 Query: 661 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 720 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY Sbjct: 661 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 720 Query: 721 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 780 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY Sbjct: 721 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 780 Query: 781 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 840 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG Sbjct: 781 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 840 Query: 841 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 900 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT Sbjct: 841 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 900 Query: 901 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA Sbjct: 901 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960 Query: 961 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 1020 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED Sbjct: 961 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 1020 Query: 1021 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1080 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE Sbjct: 1021 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1080 Query: 1081 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1140 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ Sbjct: 1081 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1140 Query: 1141 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP Sbjct: 1141 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200 Query: 1201 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1260 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT Sbjct: 1201 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1260 Query: 1261 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1320 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP Sbjct: 1261 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1320 Query: 1321 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1380 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ Sbjct: 1321 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1380 Query: 1381 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1440 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG Sbjct: 1381 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1440 Query: 1441 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1496 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT Sbjct: 1441 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1496 >gi|237757326 synaptojanin 1 isoform d [Homo sapiens] Length = 1526 Score = 1187 bits (3070), Expect = 0.0 Identities = 642/1400 (45%), Positives = 899/1400 (64%), Gaps = 91/1400 (6%) Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60 MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA Sbjct: 1 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59 Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120 YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ + Sbjct: 60 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119 Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180 +K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW Sbjct: 120 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178 Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240 LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y Sbjct: 179 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238 Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300 +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++ Sbjct: 239 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298 Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360 VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++ Sbjct: 299 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357 Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419 + D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP + Sbjct: 358 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417 Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479 V RF E F++MWS+NG S+SK++ G+ ALEGKAK GKLKDGARS++RTIQ+NFFD KQE Sbjct: 418 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKAGKLKDGARSVTRTIQNNFFDSSKQE 477 Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNV 539 AI +LL+G+ ++ADK LL + +L + ++LK+M E +++ K+IR+ +GTWNV Sbjct: 478 AIDVLLLGNTLNSDLADKARALLTTGSLRASSKVLKSMCENFYKYSKPKKIRVCVGTWNV 537 Query: 540 NGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVELSAGNIVN 598 NGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVEL+AGNIV+ Sbjct: 538 NGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVS 597 Query: 599 ASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGM 658 ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA+DTVKTGM Sbjct: 598 ASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGM 657 Query: 659 GGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSH 718 GG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FPMGR +FSH Sbjct: 658 GGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSH 717 Query: 719 DYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGP 778 DYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F EG + F P Sbjct: 718 DYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAP 777 Query: 779 TYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWS 838 TYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ ++K+ +TW+ Sbjct: 778 TYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWT 837 Query: 839 PGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS 898 PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D TV+V+++S Sbjct: 838 PGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKS 897 Query: 899 PTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKG 958 +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL ++G ++ Sbjct: 898 -SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLN 956 Query: 959 RAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDD 1018 R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E + D + Sbjct: 957 RTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAE 1016 Query: 1019 EDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSPALT----K 1061 + L+ + QP S S LG +S+ P P+ PS++P+ T Sbjct: 1017 VEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1075 Query: 1062 KKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKK 1121 + P A + K + + E + P R ++ P R P PPQRPPPP+G + Sbjct: 1076 AQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPPPSGR--SQ 1129 Query: 1122 SASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIR 1181 + A ++ YS TAR P PP+A I + +A R Sbjct: 1130 PSPQAGLAGPGPAGYS---TAR-----PTIPPRAGV----------ISAPQSHARASAGR 1171 Query: 1182 CLLEARGGASEEAL-SAVAPRDLE-------ASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233 E++ SE + S P L+ SS P P +P P A P+ P P Sbjct: 1172 LTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQP 1231 Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQ---QTVHFTIGPPETSVEAPP-------------V 1277 + +P R P E Q +T + G E+ ++ P Sbjct: 1232 NLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKA 1291 Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRK 1337 + + PVP P P + + PS ++V + P +P +P R + Sbjct: 1292 QLSVQTSPVPTP---DPKRLIQLPS-----------ATQSNVLSSVSCMPTMPPIPARSQ 1337 Query: 1338 -----KSAPAAFHLQVLQSN 1352 +S+P F + ++N Sbjct: 1338 SQENMRSSPNPFITGLTRTN 1357 >gi|237757308 synaptojanin 1 isoform b [Homo sapiens] Length = 1350 Score = 1175 bits (3039), Expect = 0.0 Identities = 630/1349 (46%), Positives = 878/1349 (65%), Gaps = 81/1349 (6%) Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60 MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA Sbjct: 40 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 98 Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120 YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ + Sbjct: 99 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 158 Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180 +K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW Sbjct: 159 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 217 Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240 LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y Sbjct: 218 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 277 Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300 +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++ Sbjct: 278 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 337 Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360 VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++ Sbjct: 338 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 396 Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419 + D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP + Sbjct: 397 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 456 Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479 V RF E F++MWS+NG S+SK++ G+ ALEGKAK LKDGARS++RTIQ+NFFD KQE Sbjct: 457 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 513 Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531 AI +LL+G+ ++ADK LL + +L V+ ++LK+M E +++ K+IR Sbjct: 514 AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 573 Query: 532 IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590 + +GTWNVNGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVE Sbjct: 574 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 633 Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650 L+AGNIV+ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA Sbjct: 634 LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 693 Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710 +DTVKTGMGG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FP Sbjct: 694 VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 753 Query: 711 MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770 MGR +FSHDYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F Sbjct: 754 MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813 Query: 771 EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830 EG + F PTYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ + Sbjct: 814 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 873 Query: 831 TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890 +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D Sbjct: 874 SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 933 Query: 891 TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950 TV+V+++S +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL Sbjct: 934 TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 992 Query: 951 VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010 ++G ++ R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E Sbjct: 993 LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1052 Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057 + D + + L+ + QP S S LG +S+ P P+ PS++P Sbjct: 1053 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1111 Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113 + T + P A + K + + E + P R ++ P R P PPQRPPP Sbjct: 1112 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1167 Query: 1114 PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNA 1173 P+G A + T ++ + GAP P AR + P + + N Sbjct: 1168 PSG---------ARSPAPTRKEFGGI-------GAPPSPGVARREMEAPKSPGTTRKDNI 1211 Query: 1174 QEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233 ++ + + L G A P S P+ A+ A L P Sbjct: 1212 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS------AGRLTPESQSK 1265 Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV-VTAP----------R 1282 K T +PL P+ F Q+ ++ PP ++ P V V AP Sbjct: 1266 TSETSKGSTF--LPEPLKPQAAFPPQS---SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1320 Query: 1283 VPPVPKPRTFQ----PGKAAERPSHRKPA 1307 PP P PR+ P +A+ +P +P+ Sbjct: 1321 TPPQPPPRSRSSHSLPSEASSQPQQEQPS 1349 Score = 35.0 bits (79), Expect = 0.54 Identities = 47/200 (23%), Positives = 66/200 (33%), Gaps = 47/200 (23%) Query: 1268 PETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP- 1326 P TS P ++ VP +P +P +A R + P++ +P A + P P + P Sbjct: 1085 PRTSPCQSPTISEGPVPSLP----IRPSRAPSR-TPGPPSAQSSPIDAQPATPLPQKDPA 1139 Query: 1327 -PLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385 PL PK PP + AP P PP +G P Sbjct: 1140 QPLEPKRPPPPRPVAPPT-------------------RPAPPQRPPPPSGARSPAPTRKE 1180 Query: 1386 TSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPK 1445 +P S G + EA PK T D + SP+ Sbjct: 1181 FGGIGAPPSPGVARREMEA-----------------PKSPGTT----RKDNIGRSQPSPQ 1219 Query: 1446 RDPIDPVSAGASAAKAELPP 1465 P AG S A+ +PP Sbjct: 1220 AGLAGPGPAGYSTARPTIPP 1239 Score = 32.3 bits (72), Expect = 3.5 Identities = 50/240 (20%), Positives = 77/240 (32%), Gaps = 46/240 (19%) Query: 1170 TTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE--PTPGAAKPETPQAPPLL 1227 T ++AE A +E + + P+ L+ SS +P ++ +P P + Sbjct: 1036 TLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTI 1095 Query: 1228 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1287 P P +P RT P S + + ++A P P+ P Sbjct: 1096 SEGPVPSLPIRPSRAPSRTPGPPSAQS---------------SPIDAQPATPLPQKDPA- 1139 Query: 1288 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVP-------PRRKK-- 1338 +P + PP PP APP P P P RK+ Sbjct: 1140 -----------------QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182 Query: 1339 --SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDG 1396 AP + + + + G T + S P AG P ST+ T P G Sbjct: 1183 GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1242 >gi|237757310 synaptojanin 1 isoform a [Homo sapiens] Length = 1612 Score = 1174 bits (3036), Expect = 0.0 Identities = 628/1343 (46%), Positives = 873/1343 (65%), Gaps = 69/1343 (5%) Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60 MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA Sbjct: 40 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 98 Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120 YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ + Sbjct: 99 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 158 Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180 +K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW Sbjct: 159 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 217 Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240 LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y Sbjct: 218 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 277 Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300 +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++ Sbjct: 278 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 337 Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360 VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++ Sbjct: 338 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 396 Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419 + D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP + Sbjct: 397 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 456 Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479 V RF E F++MWS+NG S+SK++ G+ ALEGKAK LKDGARS++RTIQ+NFFD KQE Sbjct: 457 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 513 Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531 AI +LL+G+ ++ADK LL + +L V+ ++LK+M E +++ K+IR Sbjct: 514 AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 573 Query: 532 IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590 + +GTWNVNGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVE Sbjct: 574 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 633 Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650 L+AGNIV+ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA Sbjct: 634 LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 693 Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710 +DTVKTGMGG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FP Sbjct: 694 VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 753 Query: 711 MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770 MGR +FSHDYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F Sbjct: 754 MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813 Query: 771 EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830 EG + F PTYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ + Sbjct: 814 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 873 Query: 831 TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890 +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D Sbjct: 874 SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 933 Query: 891 TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950 TV+V+++S +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL Sbjct: 934 TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 992 Query: 951 VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010 ++G ++ R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E Sbjct: 993 LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1052 Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057 + D + + L+ + QP S S LG +S+ P P+ PS++P Sbjct: 1053 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1111 Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113 + T + P A + K + + E + P R ++ P R P PPQRPPP Sbjct: 1112 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1167 Query: 1114 PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNA 1173 P+G A + T ++ + GAP P AR + P + + N Sbjct: 1168 PSG---------ARSPAPTRKEFGGI-------GAPPSPGVARREMEAPKSPGTTRKDNI 1211 Query: 1174 QEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233 ++ + + L G A P S P+ A+ A L P Sbjct: 1212 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS------AGRLTPESQSK 1265 Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVP---PVPKPR 1290 K T +PL P+ F Q+ ++ PP ++ P V A +P P P Sbjct: 1266 TSETSKGSTF--LPEPLKPQAAFPPQS---SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1320 Query: 1291 TFQPGKAAERPSHRKPASDEAPP 1313 T R SH P+ + P Sbjct: 1321 TPPQPPPRSRSSHSLPSEASSQP 1343 Score = 35.0 bits (79), Expect = 0.54 Identities = 47/200 (23%), Positives = 66/200 (33%), Gaps = 47/200 (23%) Query: 1268 PETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP- 1326 P TS P ++ VP +P +P +A R + P++ +P A + P P + P Sbjct: 1085 PRTSPCQSPTISEGPVPSLP----IRPSRAPSR-TPGPPSAQSSPIDAQPATPLPQKDPA 1139 Query: 1327 -PLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385 PL PK PP + AP P PP +G P Sbjct: 1140 QPLEPKRPPPPRPVAPPT-------------------RPAPPQRPPPPSGARSPAPTRKE 1180 Query: 1386 TSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPK 1445 +P S G + EA PK T D + SP+ Sbjct: 1181 FGGIGAPPSPGVARREMEA-----------------PKSPGTT----RKDNIGRSQPSPQ 1219 Query: 1446 RDPIDPVSAGASAAKAELPP 1465 P AG S A+ +PP Sbjct: 1220 AGLAGPGPAGYSTARPTIPP 1239 Score = 32.3 bits (72), Expect = 3.5 Identities = 50/240 (20%), Positives = 77/240 (32%), Gaps = 46/240 (19%) Query: 1170 TTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE--PTPGAAKPETPQAPPLL 1227 T ++AE A +E + + P+ L+ SS +P ++ +P P + Sbjct: 1036 TLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTI 1095 Query: 1228 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1287 P P +P RT P S + + ++A P P+ P Sbjct: 1096 SEGPVPSLPIRPSRAPSRTPGPPSAQS---------------SPIDAQPATPLPQKDPA- 1139 Query: 1288 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVP-------PRRKK-- 1338 +P + PP PP APP P P P RK+ Sbjct: 1140 -----------------QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182 Query: 1339 --SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDG 1396 AP + + + + G T + S P AG P ST+ T P G Sbjct: 1183 GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1242 >gi|237757312 synaptojanin 1 isoform c [Homo sapiens] Length = 1295 Score = 1171 bits (3029), Expect = 0.0 Identities = 628/1341 (46%), Positives = 868/1341 (64%), Gaps = 81/1341 (6%) Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60 MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA Sbjct: 1 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59 Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120 YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ + Sbjct: 60 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119 Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180 +K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW Sbjct: 120 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178 Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240 LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y Sbjct: 179 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238 Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300 +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++ Sbjct: 239 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298 Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360 VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++ Sbjct: 299 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357 Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419 + D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP + Sbjct: 358 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417 Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479 V RF E F++MWS+NG S+SK++ G+ ALEGKAK LKDGARS++RTIQ+NFFD KQE Sbjct: 418 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 474 Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531 AI +LL+G+ ++ADK LL + +L V+ ++LK+M E +++ K+IR Sbjct: 475 AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 534 Query: 532 IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590 + +GTWNVNGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVE Sbjct: 535 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 594 Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650 L+AGNIV+ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA Sbjct: 595 LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 654 Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710 +DTVKTGMGG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FP Sbjct: 655 VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 714 Query: 711 MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770 MGR +FSHDYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F Sbjct: 715 MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 774 Query: 771 EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830 EG + F PTYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ + Sbjct: 775 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 834 Query: 831 TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890 +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D Sbjct: 835 SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 894 Query: 891 TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950 TV+V+++S +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL Sbjct: 895 TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 953 Query: 951 VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010 ++G ++ R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E Sbjct: 954 LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1013 Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057 + D + + L+ + QP S S LG +S+ P P+ PS++P Sbjct: 1014 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1072 Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113 + T + P A + K + + E + P R ++ P R P PPQRPPP Sbjct: 1073 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1128 Query: 1114 PTGL---MVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKT 1170 P+G + A S GT + +I G Q P+A P + Sbjct: 1129 PSGARSPAPTRKEFGAPKSPGTTRKDNI--------GRSQPSPQAGLAGPGPAGYSTARP 1180 Query: 1171 TNAQEAEAAIRCLLEARGGA---SEEALSAVAPRDLEASSEPEP-TPGAAKPETPQAPPL 1226 T A AR A + E+ S + ++ PEP P AA P PP Sbjct: 1181 TIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPP 1240 Query: 1227 LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPV 1286 R P VP P S P + T P+ PP Sbjct: 1241 AQRLQEPLVP---------------------------VAAPMPQSGPQPNLETPPQPPPR 1273 Query: 1287 PKPRTFQPGKAAERPSHRKPA 1307 + P +A+ +P +P+ Sbjct: 1274 SRSSHSLPSEASSQPQQEQPS 1294 Score = 42.0 bits (97), Expect = 0.004 Identities = 52/221 (23%), Positives = 78/221 (35%), Gaps = 27/221 (12%) Query: 1206 SSEPEPTPGAAKPETPQAP----PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261 SS P +P P + P P+ P R P R P P+ + + P Q+ Sbjct: 1043 SSSPRTSP-CQSPTISEGPVPSLPIRPSRAPSRTPG--PPSAQSSPIDAQPATPLPQKD- 1098 Query: 1262 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP-GKAAERPSHRKPASDEAP-------- 1312 P E PP AP P P R P G + P+ ++ + ++P Sbjct: 1099 --PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNI 1156 Query: 1313 ------PGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDS 1366 P AG + P P P +PPR + H + S +L +S++ Sbjct: 1157 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA--SAGRLTPESQSKTSET 1214 Query: 1367 PSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL 1407 G + PQ F SS P + + P AAP+ Sbjct: 1215 SKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPM 1255 >gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase isoform b [Homo sapiens] Length = 893 Score = 223 bits (568), Expect = 1e-57 Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%) Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576 + +R+ E+ N + R +GTWNVNG + L WL D + Sbjct: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267 Query: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636 P DI+ +GF+E+ +LS + ++ W +++ + +Y + +LVG+ L I Sbjct: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326 Query: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696 F R +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A + R Sbjct: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386 Query: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749 N+DYK+I ++ F + N+ H+ V W GD NYR+ + EV + ++D ++ Sbjct: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446 Query: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809 LL+FDQL +Q++ K F DF+EG I F PTYKYD + +D+S KCR PAW DR+LW Sbjct: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503 Query: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869 R T + L Y EL+ SDH+PV A+ + V+ V Sbjct: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538 Query: 870 DVGARERVFQE 880 D +VF++ Sbjct: 539 DERRYRKVFED 549 >gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase isoform a [Homo sapiens] Length = 901 Score = 223 bits (568), Expect = 1e-57 Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%) Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576 + +R+ E+ N + R +GTWNVNG + L WL D + Sbjct: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267 Query: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636 P DI+ +GF+E+ +LS + ++ W +++ + +Y + +LVG+ L I Sbjct: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326 Query: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696 F R +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A + R Sbjct: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386 Query: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749 N+DYK+I ++ F + N+ H+ V W GD NYR+ + EV + ++D ++ Sbjct: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446 Query: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809 LL+FDQL +Q++ K F DF+EG I F PTYKYD + +D+S KCR PAW DR+LW Sbjct: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503 Query: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869 R T + L Y EL+ SDH+PV A+ + V+ V Sbjct: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538 Query: 870 DVGARERVFQE 880 D +VF++ Sbjct: 539 DERRYRKVFED 549 >gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor [Homo sapiens] Length = 913 Score = 206 bits (525), Expect = 1e-52 Identities = 133/423 (31%), Positives = 212/423 (50%), Gaps = 63/423 (14%) Query: 494 VADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTA 553 V+DK +L L + + +++ ++T + R GT+NVNG Q LR Sbjct: 229 VSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNG--QSPKECLRL- 285 Query: 554 ELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQK 613 WL + Q D++ VGF+E+ +LS T ++ W + + + Sbjct: 286 ----WLSNGIQAP------------DVYCVGFQEL-DLSKEAFFFHDTPKEEEWFKAVSE 328 Query: 614 AISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQ 673 + +Y + +LVG+ L ++V+ H +I +V +TV TG+ G+ GNKG V IRFQ Sbjct: 329 GLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQ 388 Query: 674 FHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCF--------PMGRNVFSHDYVFWCG 725 FH+TS C + SHL A + + RN+DYK+I ++ F P+ + +HD + W G Sbjct: 389 FHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL--TISNHDVILWLG 446 Query: 726 DFNYRI-DLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDV 784 D NYRI +L E+V ++ +D++ L +DQL++Q ++ +F+ F EG + F PTYKYD Sbjct: 447 DLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDT 506 Query: 785 GSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQY 844 GS +DTS+KCR PAW DR+LW K N+ L Y Sbjct: 507 GSDDWDTSEKCRAPAWCDRILWKGK-----------NITQ-----------------LSY 538 Query: 845 YGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEK 904 L+ SDH+PV ++ ++ V+ V+ + +E+ LD N+ S +L K Sbjct: 539 QSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVR---SLDKMENANIPSVSL-SK 594 Query: 905 NEF 907 EF Sbjct: 595 REF 597 >gi|190014578 suppressor of actin 1 [Homo sapiens] Length = 587 Score = 190 bits (482), Expect = 1e-47 Identities = 147/492 (29%), Positives = 244/492 (49%), Gaps = 51/492 (10%) Query: 27 GRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCT 86 G DD L + + +K+V + +G LG + L +G ++L+++T Sbjct: 26 GADDVLTIDRVSTEVTLAVKKDVPPSAVTR--PIFGILGTIHLVAG----NYLIVITKKI 79 Query: 87 SVGRIPDAEIYKITATDFYPLQE--------EAKEEERLIA-LKKILSSGVFYFSWPNDG 137 VG ++K T D ++ + ++ + +A L +L+ FYFS Sbjct: 80 KVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFS----- 134 Query: 138 SRFDLTVRTQKQGDDSSEW---------GNSFFWN-QLLHVPLRQHQVSCCDWLLKIICG 187 + +DLT Q+ + S E+ F WN LL Q +V + L ++ G Sbjct: 135 TTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVH--RFALPVLHG 192 Query: 188 VVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSS 247 +T+ + + K L+SR SC R G R++ RG++ +GH +NFVETEQ+++ + +S Sbjct: 193 FITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKAS 252 Query: 248 FVQIRGSVPLFWEQ-PGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGS 306 FVQ RGS+P+FW Q P L+ L + + F RH YG+QV++NL+ Sbjct: 253 FVQTRGSIPVFWSQRPNLKY--KPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQ 310 Query: 307 RGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWE--DF 364 +G E+ L + F ++ +S +G I FDFH+ K + ++L LL ++ E F Sbjct: 311 KGSEKPLEQTFATMV-SSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYF 369 Query: 365 DVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL----SSKPIV 420 V + G+ V+ Q+G R NC+DCLDRTN +QS +A L QL+ LG+ Sbjct: 370 LVDSAGQVVAN--QEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQ 427 Query: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALE-------GKAKVGKLKDGARSMSRTIQSNFF 473 D F + +K W+ N ++ +K + G+ AL+ + +G + DG SM R ++NF Sbjct: 428 DEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFS 487 Query: 474 DGVKQEAIKLLL 485 DG +Q++I L L Sbjct: 488 DGFRQDSIDLFL 499 >gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens] Length = 1132 Score = 179 bits (455), Expect = 1e-44 Identities = 135/430 (31%), Positives = 211/430 (49%), Gaps = 70/430 (16%) Query: 108 QEEAKEEERLIA--LKKILSSGVFYFSWPNDGSRFDLTVRTQKQG----DDSSEW---GN 158 +E+ K E RL+ LK + S FY+S +DLT Q+Q D W + Sbjct: 153 KEKEKLERRLLEELLKMFMDSESFYYSLT-----YDLTNSVQRQSTGERDGRPLWQKVDD 207 Query: 159 SFFWNQLLHVPLRQHQVSCCD-WLLKIICGVVTIRTVYASHKQAK--------------- 202 FFWN+ + L + D W++ +I G V I + ++ ++ Sbjct: 208 RFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQEST 267 Query: 203 ----------ACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIR 252 L+SR S R G R+ RGV+ +G+V+N+VETEQ+I++ + SFVQ R Sbjct: 268 CVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTR 327 Query: 253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEV 312 GSVP+FW Q G + RL R + F H Y +QV++NL+ G E++ Sbjct: 328 GSVPVFWSQVGYRYNPRP-RLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKI 386 Query: 313 LNRAFKK--LLWASCHAGDTPMINFDFHQFAKGGKLEKLETL------LRPQLKLHW-ED 363 + A+ K LL+ + H ++FDFH+ +G K E ++TL + +K W ++ Sbjct: 387 IGDAYLKQVLLFNNSH---LTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDE 443 Query: 364 FDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL--SSKPIVD 421 V K Q+G R+NC+DCLDRTN VQ+ IA V+ QLK LG+ +P+ Sbjct: 444 AGVICK--------QEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPV 495 Query: 422 RFVESFKAMWSLNGHSLSKVFTGSRALEG-------KAKVGKLKDGARSMSRTIQSNFFD 474 + ++ MW+ NG S+S+ + G+ AL+G + G +KDG S +R + F D Sbjct: 496 KCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKD 555 Query: 475 GVKQEAIKLL 484 +Q I L+ Sbjct: 556 AYRQAVIDLM 565 >gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A [Homo sapiens] Length = 638 Score = 179 bits (453), Expect = 2e-44 Identities = 113/334 (33%), Positives = 167/334 (50%), Gaps = 35/334 (10%) Query: 531 RIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVE 590 RI + TWNV TA D + L G DDS AD+ A+G +E+ Sbjct: 56 RITVVTWNVG-----------TAMPPDDVTSLLHLGGG----DDSDGADMIAIGLQEVNS 100 Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650 + + +A T++ W E A+ ++L++S ++ GV L +F + YH+PF+RDV Sbjct: 101 MLNKRLKDALFTDQ--WSELFMDALG-PFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQ 157 Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEIT--QKLC 708 D +TG+GG GNKG V +R CF+ HL A + ++R ++++ I Q+ Sbjct: 158 TDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQ 217 Query: 709 FPMGRNVFSHDYVFWCGDFNYRIDLTYEEVF--YFVKRQDWKKLLEFDQLQLQKSSGKIF 766 P + + HD VFW GD N+RI+ +Y+ F + + +L E DQL + K++ I Sbjct: 218 GPGAQGILDHDLVFWFGDLNFRIE-SYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPIL 276 Query: 767 KDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSD 826 K F EG +NF PT+K+DVG+ YDTS K R PAWTDR+L W+ K P Sbjct: 277 KGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRIL-WKVKAP-----------GGG 324 Query: 827 LDVDTKVRHTWSPGALQYYGRAELQASDHRPVLA 860 + H Y E SDH+PV A Sbjct: 325 PSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAA 358 >gi|40254823 SH2 containing inositol phosphatase isoform b [Homo sapiens] Length = 1188 Score = 155 bits (393), Expect = 2e-37 Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%) Query: 450 GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507 GK + K KDG+ + +K + KL+++ + E++ K + DS Sbjct: 322 GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 380 Query: 508 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567 ++L+ M + SE I I +GTWN+ N ++T W L Q Sbjct: 381 EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 433 Query: 568 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627 DS D P DI+ +G +E ++K W E L+ ++ T A Sbjct: 434 RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 480 Query: 628 --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685 L + + + +P H I + D VKTG+ GNKGAVG+ F F+ TS F+ SH Sbjct: 481 IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 540 Query: 686 LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735 LT+G + RN++Y I + L +G S ++FW GD NYR+DL Sbjct: 541 LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 598 Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790 E + +K+Q + LL DQL ++ K+F F E I F PTY+++ AY Sbjct: 599 ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 658 Query: 791 --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848 T K P+W DRVLW K +P + Y + Sbjct: 659 KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 693 Query: 849 ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906 ++ SDH PV A E V V + G +D+ + TL+ K++ Sbjct: 694 DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 744 Query: 907 --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964 F + + +++ ++G+++V F ++ L + D + + + I Sbjct: 745 TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 804 Query: 965 PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019 K+ D + E I R ++ P+ +P + L +F S+G E Sbjct: 805 IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 864 Query: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076 D++ DE + P S D + T+ APP ++T + +P Y Sbjct: 865 DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 915 Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131 VG F P L V P Q P +PP + L + S + Sbjct: 916 ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 962 Query: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191 GQ I + LP + RT S+P ++ + A Sbjct: 963 PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1004 Query: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245 +E L P E SS P+P P Q P +PR+ PP P +P + Sbjct: 1005 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1054 Query: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299 LSP ++ T E P + P P+ R+F +AE Sbjct: 1055 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1098 Query: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347 + + P S +AP A + P + PP PP KS PA HLQ Sbjct: 1099 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1153 >gi|64085167 SH2 containing inositol phosphatase isoform a [Homo sapiens] Length = 1189 Score = 155 bits (393), Expect = 2e-37 Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%) Query: 450 GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507 GK + K KDG+ + +K + KL+++ + E++ K + DS Sbjct: 323 GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 381 Query: 508 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567 ++L+ M + SE I I +GTWN+ N ++T W L Q Sbjct: 382 EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 434 Query: 568 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627 DS D P DI+ +G +E ++K W E L+ ++ T A Sbjct: 435 RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 481 Query: 628 --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685 L + + + +P H I + D VKTG+ GNKGAVG+ F F+ TS F+ SH Sbjct: 482 IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 541 Query: 686 LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735 LT+G + RN++Y I + L +G S ++FW GD NYR+DL Sbjct: 542 LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 599 Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790 E + +K+Q + LL DQL ++ K+F F E I F PTY+++ AY Sbjct: 600 ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 659 Query: 791 --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848 T K P+W DRVLW K +P + Y + Sbjct: 660 KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 694 Query: 849 ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906 ++ SDH PV A E V V + G +D+ + TL+ K++ Sbjct: 695 DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 745 Query: 907 --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964 F + + +++ ++G+++V F ++ L + D + + + I Sbjct: 746 TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 805 Query: 965 PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019 K+ D + E I R ++ P+ +P + L +F S+G E Sbjct: 806 IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 865 Query: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076 D++ DE + P S D + T+ APP ++T + +P Y Sbjct: 866 DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 916 Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131 VG F P L V P Q P +PP + L + S + Sbjct: 917 ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 963 Query: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191 GQ I + LP + RT S+P ++ + A Sbjct: 964 PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1005 Query: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245 +E L P E SS P+P P Q P +PR+ PP P +P + Sbjct: 1006 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1055 Query: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299 LSP ++ T E P + P P+ R+F +AE Sbjct: 1056 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1099 Query: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347 + + P S +AP A + P + PP PP KS PA HLQ Sbjct: 1100 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1154 >gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens] Length = 1258 Score = 153 bits (387), Expect = 1e-36 Identities = 206/870 (23%), Positives = 326/870 (37%), Gaps = 175/870 (20%) Query: 512 RILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDS 571 ++L+ M + S+ I + +GTWN+ +V +T W S L D Sbjct: 406 QLLQLMKNKHSKQDEPDMISVFIGTWNMG-------SVPPPKNVTSWFT-SKGLGKTLDE 457 Query: 572 QDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISR----SHRYILLTSA 627 + P DI+ G +E ++ + W + L+ + +R I + S Sbjct: 458 VTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQS- 504 Query: 628 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT 687 L + + + V+P H I V+ +VKTG+ GNKGAVG+ F F+ TSF F+ HLT Sbjct: 505 -LWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLT 563 Query: 688 AGQSQVKERNEDYKEITQKLCFPMGR-NVFS----HDYVFWCGDFNYRIDLTYEEVFYFV 742 +G + RN++Y +I + L + N F ++FW GD NYR+D+ +E+ ++ Sbjct: 564 SGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYI 623 Query: 743 KRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGS-------AAYDTSDKC 795 R++++ LL DQL L++ K+F F E I+F PTY+Y+ GS T + Sbjct: 624 SRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 683 Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855 P+W DR+LW K +P E +++ + Y ++ SDH Sbjct: 684 NVPSWCDRILW--KSYP------ETHIICN-----------------SYGCTDDIVTSDH 718 Query: 856 RPVLAIVEVEVQEVDVGAR------ERVFQEVSSFQGPLDAT----VVVNLQSPTLEE-K 904 PV EV V + + ++ + E S + + + S LEE K Sbjct: 719 SPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYK 778 Query: 905 NEFPEDLRT----ELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960 F D ++ ++ S + ++ + D H L+V +DG + G Sbjct: 779 KSFENDAQSSDNINFLKVQWSSRQLPTLKPILAD-IEYLQDQHLLLTVKSMDGYESYGEC 837 Query: 961 V-----KIRPKTKDWLKGLR---EEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEG 1012 V I + +L L EE R SM PT E +++ S+D + G Sbjct: 838 VVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAG 897 Query: 1013 DILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDA 1072 + P VS S P T + P +K PT + A Sbjct: 898 -----------AKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPA 946 Query: 1073 DLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGT 1132 P R+ P P+ P P G+ A+ +S Sbjct: 947 -------------------PPRAAPREEPLTPRLKPEGAPEPEGV-----AAPPPKNSFN 982 Query: 1133 HGQYSILQTA--RLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA 1190 + Y +L+ +LLP P P +A +A + + AI G Sbjct: 983 NPAYYVLEGVPHQLLPPEPPSPARA-------------PVPSATKNKVAITVPAPQLGHH 1029 Query: 1191 SEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRR--PPPRVPAIKKPTLRRTGK 1248 PR E SS E + G P PPL PP + + P +R G Sbjct: 1030 RH-------PRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGG 1082 Query: 1249 PLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE--------- 1299 + GPP P P +PP P P + G+ A Sbjct: 1083 AEAR-------------GPP-----PPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVL 1124 Query: 1300 RPSHRKPASDEAP--PGAGASVPPPLEAPP 1327 + + D AP P A +P PLE P Sbjct: 1125 QMAKTLSEVDYAPAGPARSALLPGPLELQP 1154 Score = 42.0 bits (97), Expect = 0.004 Identities = 43/164 (26%), Positives = 61/164 (37%), Gaps = 13/164 (7%) Query: 1175 EAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPP-- 1232 +A + R E R G+ + A + + EPE P +P P P PR P Sbjct: 901 KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAP--PRAAPREEPLT 958 Query: 1233 PRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP---KP 1289 PR+ P P P+ F + G P + PP +P PVP K Sbjct: 959 PRLKPEGAPEPEGVAAP-PPKNSFNNPAYYVLEGVPHQLL--PPEPPSPARAPVPSATKN 1015 Query: 1290 RTFQPGKAAERPSHRKPASDEAPPG---AGASVPPPLEAPPLVP 1330 + A + HR P E +G ++PPP PP +P Sbjct: 1016 KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLP 1059 >gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens] Length = 644 Score = 139 bits (351), Expect = 2e-32 Identities = 114/386 (29%), Positives = 174/386 (45%), Gaps = 82/386 (21%) Query: 499 GMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDW 558 G LL S ALL + + +R + + + TWN+ G K+ + L ++ Sbjct: 276 GSLLASGALLGADELARYFPDRN--------VALFVATWNMQGQKELPPS------LDEF 321 Query: 559 LLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRS 618 LL + + D++ +G +E ++++ W +LQ+ + Sbjct: 322 LLPA----------EADYAQDLYVIGVQE------------GCSDRREWETRLQETLGP- 358 Query: 619 HRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTS 678 Y+LL+SA + + +F+R + F +V TV T + + KGA+GI F F TS Sbjct: 359 -HYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTS 417 Query: 679 FCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNV--------------FSHDYVFWC 724 F FI SH T+G +V ER DY Q L P RNV D VFW Sbjct: 418 FLFITSHFTSGDGKVAERLLDYTRTVQALVLP--RNVPDTNPYRSSAADVTTRFDEVFWF 475 Query: 725 GDFNYRID---LTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK 781 GDFN+R+ + + D LL+ DQL + G IFK F E I+F P+YK Sbjct: 476 GDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYK 535 Query: 782 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA 841 +D+G YD++ K RTP++TDRVL +R +H D V ++ PG Sbjct: 536 FDIGKDTYDSTSKQRTPSYTDRVL-YRSRHKGD---------------ICPVSYSSCPG- 578 Query: 842 LQYYGRAELQASDHRPVLAIVEVEVQ 867 ++ SDHRPV + V+V+ Sbjct: 579 --------IKTSDHRPVYGLFRVKVR 596 Score = 34.7 bits (78), Expect = 0.71 Identities = 50/196 (25%), Positives = 73/196 (37%), Gaps = 25/196 (12%) Query: 1091 SPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 SP+ + S P P PP R P + + ++S G R G+ Q Sbjct: 47 SPALACSTPATPSGEDPPARAAPIAPRPPARPRLERALSLDDKGW-----RRRRFRGS-Q 100 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLL-------EARGGASEEALSAVA---P 1200 + +AR G S Q + A + CL ++RG S E S + P Sbjct: 101 EDLEARNGTSPSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNP 160 Query: 1201 RDLEASSEPE--PTPGAAKPETPQAPPLLPRRPPPRVPA-IKKPTLRRTGKPLSPEEQFE 1257 ASS P A +P+ P LLP RPPP + I +LR K S ++ Sbjct: 161 LSGVASSSPNLPHRDAAVAGSSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYK 220 Query: 1258 QQT------VHFTIGP 1267 + H ++GP Sbjct: 221 LRAQPLLVRAHSSLGP 236 Score = 31.2 bits (69), Expect = 7.8 Identities = 50/223 (22%), Positives = 78/223 (34%), Gaps = 32/223 (14%) Query: 1284 PPVPKPRTFQPGKAAERPSHRKPASDEAP----PGAGASVP-------PPLEAPPLVPKV 1332 P P+ RT Q P+ R + +AP P S P PP A P+ P+ Sbjct: 15 PQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPPARAAPIAPRP 74 Query: 1333 PPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSP 1392 P R + A L + +G + ++ +G P+ G+V +G S + P Sbjct: 75 PARPR--LERALSLDDKGWRRRRFRG-SQEDLEARNGTSPSRGSVQSEGPGAPAHSCSPP 131 Query: 1393 DSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDS-GTRSPKRDPIDP 1451 + P++ +L + S +PL + SP D Sbjct: 132 CLSTSLQEIPKSRGVLSSERGS---------------PSSGGNPLSGVASSSPNLPHRDA 176 Query: 1452 VSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLA 1494 AG+S L P L + I+ RTA +V LA Sbjct: 177 AVAGSSPRLPSLLPPRPPPALS--LDIASDSLRTANKVDSDLA 217 >gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo sapiens] Length = 448 Score = 129 bits (323), Expect = 3e-29 Identities = 102/357 (28%), Positives = 165/357 (46%), Gaps = 40/357 (11%) Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWL-LDSPQLSGATDSQDDS 575 M+ R+ +R+ I + TWNV ++ +L+D L L++ L+ Sbjct: 1 MSSRKLSGPKGRRLSIHVVTWNV-------ASAAPPLDLSDLLQLNNRNLN--------- 44 Query: 576 SPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLY 635 DI+ +G +E+ + +A+ + W L +S +I ++ ++ G+ L Sbjct: 45 --LDIYVIGLQELNSGIISLLSDAAFNDS--WSSFLMDVLSPLS-FIKVSHVRMQGILLL 99 Query: 636 IFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKE 695 +F + H+P+I+ ++ + TG+ G GNKG V I + + I HL S + Sbjct: 100 VFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQ 159 Query: 696 RNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTYEEVFYFVKRQDWKKL 750 R E + I + + C GR N+ HD + W GD N+RI D V +K + + L Sbjct: 160 RLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGL 217 Query: 751 LEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKK 810 E DQL + K + ++F EG + F PTYK+D S YDTS+K R PAWTDR+LW K+ Sbjct: 218 WEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKR 277 Query: 811 HPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ 867 P AG D +S Y SDH+PV ++E++ Sbjct: 278 QP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELK 323 >gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo sapiens] Length = 372 Score = 123 bits (308), Expect = 2e-27 Identities = 81/252 (32%), Positives = 123/252 (48%), Gaps = 18/252 (7%) Query: 621 YILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680 +I ++ ++ G+ L +F + H+P+I+ ++ + TG+ G GNKG V I + + Sbjct: 9 FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68 Query: 681 FICSHLTAGQSQVKERNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTY 735 I HL S +R E + I + + C GR N+ HD + W GD N+RI D Sbjct: 69 IINCHLPPHISNNYQRLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGL 126 Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKC 795 V +K + + L E DQL + K + ++F EG + F PTYK+D S YDTS+K Sbjct: 127 HFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKK 186 Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855 R PAWTDR+LW K+ P AG D +S Y SDH Sbjct: 187 RKPAWTDRILWRLKRQP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDH 235 Query: 856 RPVLAIVEVEVQ 867 +PV ++E++ Sbjct: 236 KPVSGTFDLELK 247 >gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo sapiens] Length = 372 Score = 123 bits (308), Expect = 2e-27 Identities = 81/252 (32%), Positives = 123/252 (48%), Gaps = 18/252 (7%) Query: 621 YILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680 +I ++ ++ G+ L +F + H+P+I+ ++ + TG+ G GNKG V I + + Sbjct: 9 FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68 Query: 681 FICSHLTAGQSQVKERNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTY 735 I HL S +R E + I + + C GR N+ HD + W GD N+RI D Sbjct: 69 IINCHLPPHISNNYQRLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGL 126 Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKC 795 V +K + + L E DQL + K + ++F EG + F PTYK+D S YDTS+K Sbjct: 127 HFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKK 186 Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855 R PAWTDR+LW K+ P AG D +S Y SDH Sbjct: 187 RKPAWTDRILWRLKRQP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDH 235 Query: 856 RPVLAIVEVEVQ 867 +PV ++E++ Sbjct: 236 KPVSGTFDLELK 247 >gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo sapiens] Length = 907 Score = 105 bits (262), Expect = 3e-22 Identities = 138/531 (25%), Positives = 218/531 (41%), Gaps = 112/531 (21%) Query: 51 KGQYG--KLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQ 108 KG G + A+G +G +R G ++VL+T + I IYK+ T+ + Sbjct: 81 KGSSGLFRAVSAFGVVGFVRFLEG----YYIVLITKRRKMADIGGHAIYKVEDTNMIYIP 136 Query: 109 EEA------KEEERLIALKKILSSGVFYFSWPNDGS---RFDLTV-----------RTQK 148 ++ E L + + S FYFS+ D S +++LTV TQ Sbjct: 137 NDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQN 196 Query: 149 QGDD--------------------SSEWGNSFFWN-QLLHV-PLRQHQVSCCDWLLKIIC 186 + + SE + WN +LL + H+ DWLL II Sbjct: 197 RQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHR----DWLLYIIH 252 Query: 187 GVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQ-------MI 239 G + + L++R S + GTRF RG N +G V+N VETEQ M Sbjct: 253 GFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMS 312 Query: 240 YMDDGVSSFVQIRGSVPLFWEQP-GLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQ 298 + SS+VQ+RGSVPL+W Q + + L + + A H + +++G Sbjct: 313 FTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQA-DPFAHVAALHFDQMFQRFGSP 371 Query: 299 VVV-NLLGSRGGEEVLNRAFKKLLWASCHAGD-------TPMINFDFHQFAKGGKLEKLE 350 +++ NL+ R + ++L+ A + I +D ++ K L+ Sbjct: 372 IIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLD 431 Query: 351 ------------------------TLLRPQLKLHWEDFDVFTKGENVSP--RFQKGTLRM 384 ++LRP K W + G V P R Q G LR Sbjct: 432 RLNVIAESVVKKTGFFVNRPDSYCSILRPDEK--WNEL-----GGCVIPTGRLQTGILRT 484 Query: 385 NCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD---RFVESFKAMWSLNGHSLSKV 441 NC+DCLDRTNT Q + L QL +LGL KP + V F+ ++ +G +LS Sbjct: 485 NCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQ 544 Query: 442 FTGSRALEGKAKVGKL-------KDGARSMSRTIQSNFFDGVKQEAIKLLL 485 + GS+ + K+ KD +++SR + F D +Q++I L L Sbjct: 545 YGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFL 595 >gi|47132519 Ras association and pleckstrin homology domains 1 isoform 1 [Homo sapiens] Length = 1250 Score = 68.6 bits (166), Expect = 4e-11 Identities = 102/429 (23%), Positives = 146/429 (34%), Gaps = 57/429 (13%) Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQY 1136 L + + V + PS L P P PP PP PPPP L +SA A ++ +Y Sbjct: 609 LSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL-PSQSAPSAGSAAPMFVKY 667 Query: 1137 SI---LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE 1193 S LQ A GA +PP S+ + + N G A + Sbjct: 668 STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQ 727 Query: 1194 ALSAVAPRDLEASSEPEP-------------TPGAAKPETPQAPPLLPRRPPPRVPAIKK 1240 A L S P P P P P PL P+ PP + I Sbjct: 728 LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPA 787 Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKP-------RTF- 1292 PT +T P+ + T + + A + +P PPVP P ++F Sbjct: 788 PTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFC 847 Query: 1293 ---QPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVL 1349 P + PS K + + PP PP +E+ PL P +S PA Sbjct: 848 AKPPPSPLSPVPSVVKQIASQFPP---PPTPPAMESQPLKPVPANVAPQSPPAVKAKPKW 904 Query: 1350 QSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLST---------SSATSPDSDGTKAM 1400 Q +S + S D P PP + VFP +++ +PD G+ Sbjct: 905 QPSS-----IPVPSPDFPP-PPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK 958 Query: 1401 KPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPI----DPVSAGA 1456 K G + P P N+ + SS + P D + P + Sbjct: 959 KTSKTSSPGGKKPP-------PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESG 1011 Query: 1457 SAAKAELPP 1465 S +K LPP Sbjct: 1012 SPSKETLPP 1020 Score = 53.9 bits (128), Expect = 1e-06 Identities = 66/267 (24%), Positives = 97/267 (36%), Gaps = 36/267 (13%) Query: 1086 EFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLL 1145 +F P SL P P PP P PPPP +AS SG+ G+ + ++ Sbjct: 915 DFPPPPPESSLVFP--PPPPSPVPAPPPPP----PPTASPTPDKSGSPGKKTSKTSS--- 965 Query: 1146 PGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEA 1205 PG + PP P IK+++ E E + + + +S P Sbjct: 966 PGGKKPPPT-------PQRNSSIKSSSGAEHP-------EPKRPSVDSLVSKFTPPAESG 1011 Query: 1206 SSEPEPTPGAAKPETPQAPPL----LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261 S E P A P P L LP + K P L GK E Sbjct: 1012 SPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDS 1071 Query: 1262 HFTIGPPETSVEAPPVV--------TAPRVPPV-PKPRTFQPGKAAERPSHRKPASDEAP 1312 F PPET + PP+ T+P+V V P+P+ + + P +P +++ Sbjct: 1072 DFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDST 1131 Query: 1313 PGAGASVPPPLEAPPLVPKVPPRRKKS 1339 A + +VP+VP K S Sbjct: 1132 RLTQAEISEQPTMATVVPQVPTSPKSS 1158 Score = 42.7 bits (99), Expect = 0.003 Identities = 70/341 (20%), Positives = 104/341 (30%), Gaps = 77/341 (22%) Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRP 1104 P T APP+ +P + K+ P + + +P P P Sbjct: 796 PVVTQAAPPTPTPPVPPAKKQPAFP-------------------------ASYIP--PSP 828 Query: 1105 PQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYN 1164 P PP PPPT + + S + + Q A P P P S+P Sbjct: 829 PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP-- 882 Query: 1165 VKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPET---- 1220 +K + A ++ A++ A + SS P P+P P Sbjct: 883 LKPVPANVAPQSPPAVK-----------------AKPKWQPSSIPVPSPDFPPPPPESSL 925 Query: 1221 --PQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVV 1278 P PP PPP P PT ++G P G + +P Sbjct: 926 VFPPPPPSPVPAPPPPPPPTASPTPDKSGSP----------------GKKTSKTSSP--- 966 Query: 1279 TAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKK 1338 + PP P P+ K++ H +P PP P +PP Sbjct: 967 -GGKKPP-PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP 1024 Query: 1339 SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFP 1379 P +L + L QG + SG + FP Sbjct: 1025 PKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFP 1065 Score = 32.7 bits (73), Expect = 2.7 Identities = 72/334 (21%), Positives = 108/334 (32%), Gaps = 72/334 (21%) Query: 1042 SDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNR 1101 S VP P PP+ SP K SP + S + Sbjct: 933 SPVPAPPPPPPPTASPTPDKS---------------------------GSPGKKTSKTSS 965 Query: 1102 PRPPQPPQRPPPPTGLMVKKSAS-----------DASISSGTHGQYSILQTARLLPGAPQ 1150 P +PP P P +K S+ D+ +S T S + LP P Sbjct: 966 PGGKKPP--PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLP-PPA 1022 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210 PPK N+ + A+A + L RG S P S P Sbjct: 1023 APPKPGKLNLSGVNLPGVLQQGCVSAKAPV---LSGRGKDSVVEF----PSPPSDSDFPP 1075 Query: 1211 PTPGAAKPETP-QAPPLLPRRPPPRVPAI-------KKPTLRRTGKPLSPEEQFEQQTVH 1262 P P P P + P + P+V + K ++++ P P+ + Sbjct: 1076 PPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQ 1135 Query: 1263 FTIGPPETSVEAPPVVT-APRVPPVPKPR-TFQPGKAAE--RPSHRKPASDEAPPGAGAS 1318 I E P + T P+VP PK + QPG A+ R RK + + S Sbjct: 1136 AEIS------EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMS 1189 Query: 1319 VPPP------LEAPPLVPKVPPRRKKSAPAAFHL 1346 P + PP P++ ++K+ H+ Sbjct: 1190 RAEPTATMDDMALPPPPPELLSDQQKAGYGGSHI 1223 >gi|153792074 proline rich 12 [Homo sapiens] Length = 2036 Score = 67.4 bits (163), Expect = 1e-10 Identities = 70/258 (27%), Positives = 98/258 (37%), Gaps = 37/258 (14%) Query: 1091 SPSRSL--SVPNRPRPPQPPQRP----PPPTGLMVKKSASDASISSGTHGQYSILQTARL 1144 SP +S+ SVP R PQPP P PPP+G A +A+ S G L Sbjct: 1308 SPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEG------------L 1355 Query: 1145 LPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLE 1204 G P P R N++ + + ++ E ++ A+ +E++S+ + Sbjct: 1356 GLGCPS--PCKRLDEELKRNLETLPSFSSDEEDSV------AKNRDLQESISSA----IS 1403 Query: 1205 ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 A +P P G TP PPL P P P + P L +PE ++ T Sbjct: 1404 ALDDP-PLAGPKDTSTPDGPPLAPAAAVPGPPPL--PGLPSANSNGTPEPPLLEEKPPPT 1460 Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLE 1324 P T PP P P +P P P A PS P PP PPP Sbjct: 1461 PPPAPTPQPQPPPPPPPPQPALPSP----PPLVAPTPSSPPPPPLPPPPPPAMPSPPPPP 1516 Query: 1325 APPLVPKVPPRRKKSAPA 1342 P P P + +AP+ Sbjct: 1517 PPAAAPLAAPPEEPAAPS 1534 Score = 43.1 bits (100), Expect = 0.002 Identities = 85/357 (23%), Positives = 117/357 (32%), Gaps = 67/357 (18%) Query: 1029 PGVSDSELGGDDLSDVPGPTA-LAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEF 1087 PGV G LS V LAPP + D ++L+ G Sbjct: 578 PGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLA-----GPGGPP 632 Query: 1088 RHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPG 1147 R+ + + + P PP R GL+ + A+DAS G G G Sbjct: 633 AERTEDEEFLIQHLLQAPSPP-RTSGADGLVGEDGAADASKGLGGSGGAG---------G 682 Query: 1148 APQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLL------------EARGGASEEAL 1195 P P + + Y+++ + T+A E A L RGG + E L Sbjct: 683 PPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAALELGLGRLKEKKKGPERGGETPEGL 742 Query: 1196 SA------VAPRDLEA---SSEPEPTPGAAKPET-----------PQAPPLLPRRPPPRV 1235 + ++L A S P P P A + P P +LP PP + Sbjct: 743 ATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLL 802 Query: 1236 PAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP- 1294 P++ SP + VH P T AP P PP P P + Sbjct: 803 PSV-------LSHAPSPSPSASKVGVHLL--EPATRDGAPQPPPPPPPPPPPMPLQLEAH 853 Query: 1295 ----GKAAERPSHR-KPASDEAPPGAGASVPPPLEAPPLVP----KVPPRRKKSAPA 1342 G PS R +P PPGA + LE P P PP + PA Sbjct: 854 LRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPA 910 Score = 42.0 bits (97), Expect = 0.004 Identities = 84/336 (25%), Positives = 107/336 (31%), Gaps = 93/336 (27%) Query: 1035 ELGGDDLSDV--PGPTALAP------PSKSPALTKKKQH---PTYKDDADLVELKRELEA 1083 E GG DL V P P L P PS SP+ +K H P +D A Sbjct: 784 EAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGA----------- 832 Query: 1084 VGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAR 1143 P+PP PP PPPP L + +A + S HG + R Sbjct: 833 ------------------PQPPPPPPPPPPPMPLQL-----EAHLRS--HGLEPAAPSPR 867 Query: 1144 LLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL 1203 L P PP A QE A+ L A G + V P Sbjct: 868 LRPEESLDPPGA-----------------MQELLGALEPLPPAPGD------TGVGP--- 901 Query: 1204 EASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP--EEQFEQQTV 1261 +SE + GA + +PQ PR P L+ + P EE F Sbjct: 902 -PNSEGKDPAGAYRSPSPQGTK-APRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAA 959 Query: 1262 --HFTIGPPETSVEAPPVVTAPRVPPVPKP-RTFQPGKAA-------------ERPSHRK 1305 + GPPE + P PP P + PG+A+ +P Sbjct: 960 DDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELP 1019 Query: 1306 PASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341 + P G S P PP P PP S P Sbjct: 1020 STVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEP 1055 Score = 36.6 bits (83), Expect = 0.19 Identities = 67/270 (24%), Positives = 95/270 (35%), Gaps = 60/270 (22%) Query: 1071 DADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASI-- 1128 DA ++ L LE+ G S S LS P Q P PT L + + +S Sbjct: 85 DASVMNLISALESRGPQPGPSASSLLSQFRSPSW-QTAMHTPGPTELFISGALPGSSTFP 143 Query: 1129 SSGTHGQYSI----------LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEA 1178 SS Y + ++ L P PP G+ P++V +K + A + Sbjct: 144 SSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPA--NGLLSPHDVLHLKPSQAPTVPS 201 Query: 1179 AIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAI 1238 ++ A GG + P L + P PG P PP PPPR Sbjct: 202 SLGFERLAGGGV-------LGPAGLGPAQTPPYRPG------PPDPP-----PPPRHLPT 243 Query: 1239 KKPTLRRTGKPLSPEEQFEQQTVHFT---IGPPETSVEAPPVVTAPRVPPVPKPRTFQPG 1295 + L + + EQ Q +F+ GPP PP PR V K Sbjct: 244 QFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPP------PPERALPRQDTVIK------- 290 Query: 1296 KAAERPSHRKPASDEAPPGAGASVPPPLEA 1325 +++PAS + PP PPP A Sbjct: 291 ------HYQRPASAQPPP-----PPPPAHA 309 Score = 35.4 bits (80), Expect = 0.42 Identities = 30/112 (26%), Positives = 46/112 (41%), Gaps = 11/112 (9%) Query: 1231 PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRV-PPVPKP 1289 PPP+ PA KP +PE+ ++ T PET++ PP P + PV K Sbjct: 1692 PPPKAPAPPP-------KPETPEKTTSEKPPEQT---PETAMPEPPAPEKPSLLRPVEKE 1741 Query: 1290 RTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341 + + ERP + A+ S+ A +PK P + K+ P Sbjct: 1742 KEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEP 1793 Score = 31.2 bits (69), Expect = 7.8 Identities = 28/120 (23%), Positives = 43/120 (35%), Gaps = 2/120 (1%) Query: 1099 PNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTG 1158 P P PP PP+ P L+ SA+ A+ + Y+ A P + P+ T Sbjct: 229 PGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTV 288 Query: 1159 ISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKP 1218 I + A++ L G S ++ A EP+PGA +P Sbjct: 289 IKHYQRPASAQPPPPPPPAHALQHYLSC--GGSYPSMGHRANLACSPLGGGEPSPGAGEP 346 >gi|189181724 proteoglycan 4 isoform D [Homo sapiens] Length = 1270 Score = 67.0 bits (162), Expect = 1e-10 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%) Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099 P PT P+ K PA T K PT K+ A K E +P P Sbjct: 270 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 327 Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159 P+ P P + P PT + + T + + P P++P T Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 379 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218 P K+ T + A + E ++ A + + EP PT P P Sbjct: 380 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436 Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277 TP+ P P P+ P P P PT + P +P+E P+ P Sbjct: 437 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 496 Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334 AP P P P T + A P P + E AP A+ P P E P PK P Sbjct: 497 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 555 Query: 1335 RRKKSAPA 1342 PA Sbjct: 556 PTTPKEPA 563 Score = 63.2 bits (152), Expect = 2e-09 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%) Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095 P PT + AP + K PA T K PT + K + + +P+ + Sbjct: 232 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 291 Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153 S P P+ P P P++P P T + + + + T + T P P++P Sbjct: 292 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 348 Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213 A T KP + E A E +E + EP PT Sbjct: 349 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 407 Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 + P TP+ P P P+ P P P PT + P +P+E T Sbjct: 408 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467 Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317 P+ P TAP P P T + P K A P P + E P Sbjct: 468 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 527 Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342 P P A P PK P PA Sbjct: 528 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 555 Score = 63.2 bits (152), Expect = 2e-09 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%) Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103 P PT P +P TKK T K+ A + + +P + + + P +P Sbjct: 450 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 507 Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157 P P P P PT ++ A + + + T + + P P++P Sbjct: 508 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 567 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216 + P K T +E + E A + +P PT P Sbjct: 568 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623 Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274 P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ + Sbjct: 624 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 683 Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328 P P TAP P P P T P P + E PP + S P + P Sbjct: 684 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 734 Query: 1329 VPKVP 1333 + K P Sbjct: 735 IHKSP 739 Score = 60.1 bits (144), Expect = 2e-08 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%) Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 +L+ P P P P + P PT +K + + + T T + P P+ Sbjct: 209 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 260 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206 +P T P K+ T +E + + + + + P++ + Sbjct: 261 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 320 Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262 + EPTP K P T + P P+ P P P PT + P +P+E T Sbjct: 321 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 380 Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309 T P T+ E P T AP P P P T + A P P + Sbjct: 381 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 439 Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341 + P + P E P PK P KK AP Sbjct: 440 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 468 Score = 56.2 bits (134), Expect = 2e-07 Identities = 67/264 (25%), Positives = 98/264 (37%), Gaps = 33/264 (12%) Query: 1091 SPSRSLSVPNRPRPPQPPQR-PPPPTGLMVKKSAS-DASISSGTHGQYSILQTARLLPGA 1148 SP + + P PRP PP T L V K + + ++ T+ Q S G Sbjct: 115 SPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS-------TDGK 167 Query: 1149 PQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA--SEEALSAVAPRDLEAS 1206 + T + + K + T+ A+ + +G A + + + P++ ++ Sbjct: 168 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST 227 Query: 1207 SEPEPTPGAAK--PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 + EPTP K P TP+ P + P P PT + P +P+E Sbjct: 228 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP--------- 278 Query: 1265 IGPPETSVEAPPVVT--APRVPPVPKPRTFQPGK-AAERPSHRKPASDEAPPGAGASVPP 1321 P T+ E P T AP P P P T P K A P P + + P P Sbjct: 279 --APTTTKEPAPTTTKSAPTTPKEPAPTT--PKKPAPTTPKEPAPTTPKEPTPTTPKEPA 334 Query: 1322 PL--EAPPLVPK--VPPRRKKSAP 1341 P E P PK P KK AP Sbjct: 335 PTTKEPAPTTPKEPAPTAPKKPAP 358 Score = 43.5 bits (101), Expect = 0.002 Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 43/260 (16%) Query: 1105 PQPPQRPPPPTGLM---VKKSASDASISSGTHGQYSI---LQTARLLPGAPQQPPKARTG 1158 P+PP +GL K + D S + H + S + TA+ + P PP + T Sbjct: 80 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNKVSTSPKITTAKPINPRPSLPPNSDTS 137 Query: 1159 ------ISKPYNV--KQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSE-- 1208 ++K V K+ TTN Q + A+ S E SA +DL +S+ Sbjct: 138 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA---KDLAPTSKVL 194 Query: 1209 PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266 +PTP K ET P L P+ P P P K T K +P TI Sbjct: 195 AKPTP---KAETTTKGPALTTPKEPTPTTP---KEPASTTPKEPTPT----------TIK 238 Query: 1267 PPETSVEAPPVVTAPRVPPVPK----PRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322 T+ + P T P PK T +P + + AP ++ P Sbjct: 239 SAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 298 Query: 1323 LEAPPLVPKVPPRRKKSAPA 1342 E P PK P PA Sbjct: 299 KEPAPTTPKKPAPTTPKEPA 318 >gi|189181722 proteoglycan 4 isoform C [Homo sapiens] Length = 1311 Score = 67.0 bits (162), Expect = 1e-10 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%) Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099 P PT P+ K PA T K PT K+ A K E +P P Sbjct: 311 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 368 Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159 P+ P P + P PT + + T + + P P++P T Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 420 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218 P K+ T + A + E ++ A + + EP PT P P Sbjct: 421 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477 Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277 TP+ P P P+ P P P PT + P +P+E P+ P Sbjct: 478 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 537 Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334 AP P P P T + A P P + E AP A+ P P E P PK P Sbjct: 538 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 596 Query: 1335 RRKKSAPA 1342 PA Sbjct: 597 PTTPKEPA 604 Score = 63.2 bits (152), Expect = 2e-09 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%) Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095 P PT + AP + K PA T K PT + K + + +P+ + Sbjct: 273 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 332 Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153 S P P+ P P P++P P T + + + + T + T P P++P Sbjct: 333 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 389 Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213 A T KP + E A E +E + EP PT Sbjct: 390 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 448 Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 + P TP+ P P P+ P P P PT + P +P+E T Sbjct: 449 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508 Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317 P+ P TAP P P T + P K A P P + E P Sbjct: 509 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 568 Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342 P P A P PK P PA Sbjct: 569 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 596 Score = 63.2 bits (152), Expect = 2e-09 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%) Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103 P PT P +P TKK T K+ A + + +P + + + P +P Sbjct: 491 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 548 Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157 P P P P PT ++ A + + + T + + P P++P Sbjct: 549 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 608 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216 + P K T +E + E A + +P PT P Sbjct: 609 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664 Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274 P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ + Sbjct: 665 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 724 Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328 P P TAP P P P T P P + E PP + S P + P Sbjct: 725 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 775 Query: 1329 VPKVP 1333 + K P Sbjct: 776 IHKSP 780 Score = 60.1 bits (144), Expect = 2e-08 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%) Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 +L+ P P P P + P PT +K + + + T T + P P+ Sbjct: 250 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 301 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206 +P T P K+ T +E + + + + + P++ + Sbjct: 302 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 361 Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262 + EPTP K P T + P P+ P P P PT + P +P+E T Sbjct: 362 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 421 Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309 T P T+ E P T AP P P P T + A P P + Sbjct: 422 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 480 Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341 + P + P E P PK P KK AP Sbjct: 481 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 509 Score = 56.2 bits (134), Expect = 2e-07 Identities = 67/264 (25%), Positives = 98/264 (37%), Gaps = 33/264 (12%) Query: 1091 SPSRSLSVPNRPRPPQPPQR-PPPPTGLMVKKSAS-DASISSGTHGQYSILQTARLLPGA 1148 SP + + P PRP PP T L V K + + ++ T+ Q S G Sbjct: 156 SPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS-------TDGK 208 Query: 1149 PQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA--SEEALSAVAPRDLEAS 1206 + T + + K + T+ A+ + +G A + + + P++ ++ Sbjct: 209 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST 268 Query: 1207 SEPEPTPGAAK--PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 + EPTP K P TP+ P + P P PT + P +P+E Sbjct: 269 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP--------- 319 Query: 1265 IGPPETSVEAPPVVT--APRVPPVPKPRTFQPGK-AAERPSHRKPASDEAPPGAGASVPP 1321 P T+ E P T AP P P P T P K A P P + + P P Sbjct: 320 --APTTTKEPAPTTTKSAPTTPKEPAPTT--PKKPAPTTPKEPAPTTPKEPTPTTPKEPA 375 Query: 1322 PL--EAPPLVPK--VPPRRKKSAP 1341 P E P PK P KK AP Sbjct: 376 PTTKEPAPTTPKEPAPTAPKKPAP 399 Score = 43.5 bits (101), Expect = 0.002 Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 43/260 (16%) Query: 1105 PQPPQRPPPPTGLM---VKKSASDASISSGTHGQYSI---LQTARLLPGAPQQPPKARTG 1158 P+PP +GL K + D S + H + S + TA+ + P PP + T Sbjct: 121 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNKVSTSPKITTAKPINPRPSLPPNSDTS 178 Query: 1159 ------ISKPYNV--KQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSE-- 1208 ++K V K+ TTN Q + A+ S E SA +DL +S+ Sbjct: 179 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA---KDLAPTSKVL 235 Query: 1209 PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266 +PTP K ET P L P+ P P P K T K +P TI Sbjct: 236 AKPTP---KAETTTKGPALTTPKEPTPTTP---KEPASTTPKEPTPT----------TIK 279 Query: 1267 PPETSVEAPPVVTAPRVPPVPK----PRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322 T+ + P T P PK T +P + + AP ++ P Sbjct: 280 SAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 339 Query: 1323 LEAPPLVPKVPPRRKKSAPA 1342 E P PK P PA Sbjct: 340 KEPAPTTPKKPAPTTPKEPA 359 >gi|189181720 proteoglycan 4 isoform B [Homo sapiens] Length = 1363 Score = 67.0 bits (162), Expect = 1e-10 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%) Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099 P PT P+ K PA T K PT K+ A K E +P P Sbjct: 363 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 420 Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159 P+ P P + P PT + + T + + P P++P T Sbjct: 421 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 472 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218 P K+ T + A + E ++ A + + EP PT P P Sbjct: 473 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529 Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277 TP+ P P P+ P P P PT + P +P+E P+ P Sbjct: 530 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 589 Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334 AP P P P T + A P P + E AP A+ P P E P PK P Sbjct: 590 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 648 Query: 1335 RRKKSAPA 1342 PA Sbjct: 649 PTTPKEPA 656 Score = 63.2 bits (152), Expect = 2e-09 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%) Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095 P PT + AP + K PA T K PT + K + + +P+ + Sbjct: 325 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 384 Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153 S P P+ P P P++P P T + + + + T + T P P++P Sbjct: 385 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 441 Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213 A T KP + E A E +E + EP PT Sbjct: 442 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 500 Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 + P TP+ P P P+ P P P PT + P +P+E T Sbjct: 501 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560 Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317 P+ P TAP P P T + P K A P P + E P Sbjct: 561 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 620 Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342 P P A P PK P PA Sbjct: 621 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 648 Score = 63.2 bits (152), Expect = 2e-09 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%) Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103 P PT P +P TKK T K+ A + + +P + + + P +P Sbjct: 543 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 600 Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157 P P P P PT ++ A + + + T + + P P++P Sbjct: 601 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 660 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216 + P K T +E + E A + +P PT P Sbjct: 661 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716 Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274 P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ + Sbjct: 717 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 776 Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328 P P TAP P P P T P P + E PP + S P + P Sbjct: 777 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 827 Query: 1329 VPKVP 1333 + K P Sbjct: 828 IHKSP 832 Score = 60.1 bits (144), Expect = 2e-08 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%) Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 +L+ P P P P + P PT +K + + + T T + P P+ Sbjct: 302 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 353 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206 +P T P K+ T +E + + + + + P++ + Sbjct: 354 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 413 Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262 + EPTP K P T + P P+ P P P PT + P +P+E T Sbjct: 414 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 473 Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309 T P T+ E P T AP P P P T + A P P + Sbjct: 474 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 532 Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341 + P + P E P PK P KK AP Sbjct: 533 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 561 Score = 45.1 bits (105), Expect = 5e-04 Identities = 72/286 (25%), Positives = 104/286 (36%), Gaps = 47/286 (16%) Query: 1079 RELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM---VKKSASDASISSGTHGQ 1135 REL+ + + +R+ P P+PP +GL K + D S + H + Sbjct: 151 RELQKKLKVKDNKKNRTKKKPT----PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNK 204 Query: 1136 YSI---LQTARLLPGAPQQPPKARTG------ISKPYNV--KQIKTTNAQEAEAAIRCLL 1184 S + TA+ + P PP + T ++K V K+ TTN Q + Sbjct: 205 VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 264 Query: 1185 EARGGASEEALSAVAPRDLEASSE--PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKK 1240 A+ S E SA +DL +S+ +PTP K ET P L P+ P P P K Sbjct: 265 SAKETQSIEKTSA---KDLAPTSKVLAKPTP---KAETTTKGPALTTPKEPTPTTP---K 315 Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPK----PRTFQPGK 1296 T K +P TI T+ + P T P PK T +P Sbjct: 316 EPASTTPKEPTPT----------TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 365 Query: 1297 AAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA 1342 + + AP ++ P E P PK P PA Sbjct: 366 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411 Score = 39.3 bits (90), Expect = 0.029 Identities = 54/261 (20%), Positives = 90/261 (34%), Gaps = 27/261 (10%) Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASIS-----SGTHGQYSILQTARLLPGAPQQPPKART 1157 R P+PP + + ++ + S+S S + S T R + + A Sbjct: 94 RSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSA--ANR 151 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217 + K VK K ++ +++ G + V D +S + + Sbjct: 152 ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPD---TSTTQHNKVSTS 208 Query: 1218 PETPQAPPLLPRRP-PPRVPAIKKPTLR-------------RTGKPLSPEEQFEQQTVHF 1263 P+ A P+ PR PP K+ +L T K S + + + + Sbjct: 209 PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 268 Query: 1264 TIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP- 1322 T +TS + + P PK T G A P P + + P P P Sbjct: 269 TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT 328 Query: 1323 -LEAPPLVPKVP-PRRKKSAP 1341 +++ P PK P P KSAP Sbjct: 329 TIKSAPTTPKEPAPTTTKSAP 349 >gi|67190163 proteoglycan 4 isoform A [Homo sapiens] Length = 1404 Score = 67.0 bits (162), Expect = 1e-10 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%) Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099 P PT P+ K PA T K PT K+ A K E +P P Sbjct: 404 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 461 Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159 P+ P P + P PT + + T + + P P++P T Sbjct: 462 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 513 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218 P K+ T + A + E ++ A + + EP PT P P Sbjct: 514 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570 Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277 TP+ P P P+ P P P PT + P +P+E P+ P Sbjct: 571 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 630 Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334 AP P P P T + A P P + E AP A+ P P E P PK P Sbjct: 631 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 689 Query: 1335 RRKKSAPA 1342 PA Sbjct: 690 PTTPKEPA 697 Score = 63.2 bits (152), Expect = 2e-09 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%) Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095 P PT + AP + K PA T K PT + K + + +P+ + Sbjct: 366 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 425 Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153 S P P+ P P P++P P T + + + + T + T P P++P Sbjct: 426 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 482 Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213 A T KP + E A E +E + EP PT Sbjct: 483 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 541 Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 + P TP+ P P P+ P P P PT + P +P+E T Sbjct: 542 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601 Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317 P+ P TAP P P T + P K A P P + E P Sbjct: 602 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 661 Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342 P P A P PK P PA Sbjct: 662 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 689 Score = 63.2 bits (152), Expect = 2e-09 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%) Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103 P PT P +P TKK T K+ A + + +P + + + P +P Sbjct: 584 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 641 Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157 P P P P PT ++ A + + + T + + P P++P Sbjct: 642 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 701 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216 + P K T +E + E A + +P PT P Sbjct: 702 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757 Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274 P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ + Sbjct: 758 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 817 Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328 P P TAP P P P T P P + E PP + S P + P Sbjct: 818 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 868 Query: 1329 VPKVP 1333 + K P Sbjct: 869 IHKSP 873 Score = 60.1 bits (144), Expect = 2e-08 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%) Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 +L+ P P P P + P PT +K + + + T T + P P+ Sbjct: 343 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 394 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206 +P T P K+ T +E + + + + + P++ + Sbjct: 395 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 454 Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262 + EPTP K P T + P P+ P P P PT + P +P+E T Sbjct: 455 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 514 Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309 T P T+ E P T AP P P P T + A P P + Sbjct: 515 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 573 Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341 + P + P E P PK P KK AP Sbjct: 574 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 602 Score = 45.1 bits (105), Expect = 5e-04 Identities = 72/286 (25%), Positives = 104/286 (36%), Gaps = 47/286 (16%) Query: 1079 RELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM---VKKSASDASISSGTHGQ 1135 REL+ + + +R+ P P+PP +GL K + D S + H + Sbjct: 192 RELQKKLKVKDNKKNRTKKKPT----PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNK 245 Query: 1136 YSI---LQTARLLPGAPQQPPKARTG------ISKPYNV--KQIKTTNAQEAEAAIRCLL 1184 S + TA+ + P PP + T ++K V K+ TTN Q + Sbjct: 246 VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 305 Query: 1185 EARGGASEEALSAVAPRDLEASSE--PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKK 1240 A+ S E SA +DL +S+ +PTP K ET P L P+ P P P K Sbjct: 306 SAKETQSIEKTSA---KDLAPTSKVLAKPTP---KAETTTKGPALTTPKEPTPTTP---K 356 Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPK----PRTFQPGK 1296 T K +P TI T+ + P T P PK T +P Sbjct: 357 EPASTTPKEPTPT----------TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 406 Query: 1297 AAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA 1342 + + AP ++ P E P PK P PA Sbjct: 407 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452 Score = 39.3 bits (90), Expect = 0.029 Identities = 54/261 (20%), Positives = 90/261 (34%), Gaps = 27/261 (10%) Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASIS-----SGTHGQYSILQTARLLPGAPQQPPKART 1157 R P+PP + + ++ + S+S S + S T R + + A Sbjct: 135 RSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSA--ANR 192 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217 + K VK K ++ +++ G + V D +S + + Sbjct: 193 ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPD---TSTTQHNKVSTS 249 Query: 1218 PETPQAPPLLPRRP-PPRVPAIKKPTLR-------------RTGKPLSPEEQFEQQTVHF 1263 P+ A P+ PR PP K+ +L T K S + + + + Sbjct: 250 PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 309 Query: 1264 TIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP- 1322 T +TS + + P PK T G A P P + + P P P Sbjct: 310 TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT 369 Query: 1323 -LEAPPLVPKVP-PRRKKSAP 1341 +++ P PK P P KSAP Sbjct: 370 TIKSAPTTPKEPAPTTTKSAP 390 >gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] Length = 416 Score = 65.1 bits (157), Expect = 5e-10 Identities = 81/322 (25%), Positives = 104/322 (32%), Gaps = 33/322 (10%) Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP----KART 1157 P PP PQ PPP G + G Q PG PQ PP K+R+ Sbjct: 51 PSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS 110 Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217 S P + +G + P + P G K Sbjct: 111 PRSPPG---------------------KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 149 Query: 1218 PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277 P+ P PP P+ PPP+ + + GKP P Q Q P + P Sbjct: 150 PQGP-PPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 208 Query: 1278 VTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335 P+ PP P KP+ P G + + P + PP G + P PP P+ PP Sbjct: 209 GNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 268 Query: 1336 RKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGH---PPAAGTVFPQGDFLSTSSATSP 1392 + + P G SS SP G PP G PQG P Sbjct: 269 QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 328 Query: 1393 DSDGTKAMKPEAAPLLGDYQDP 1414 G KP+ P G Q P Sbjct: 329 PPQG--GNKPQGPPPPGKPQGP 348 Score = 61.2 bits (147), Expect = 7e-09 Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 17/324 (5%) Query: 1100 NRPRPPQPPQRP--PPPTGLMVKKSASDASISSGTHGQ-YSILQTARLLPGAPQQPP--- 1153 N+P+ P PP +P PPP G + S G Q + Q PG PQ PP Sbjct: 87 NKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 146 Query: 1154 -KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT 1212 G P + ++ ++ + +G + P + P Sbjct: 147 GNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 206 Query: 1213 PGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSV 1272 G KP+ P PP P+ PPP+ + GKP P Q Q P + Sbjct: 207 QGGNKPQGP-PPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 265 Query: 1273 EAPPVVTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVP 1330 P P+ PP P KP+ P G + R S P + PP G + P PP P Sbjct: 266 PPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 325 Query: 1331 KVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSAT 1390 + PP + + P G S+ SP G P PQ + + Sbjct: 326 QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGP----PQQE--GNNPQG 379 Query: 1391 SPDSDGTKAMKPEAAPLLGDYQDP 1414 P G +P+A P G Q P Sbjct: 380 PPPPAGGNPQQPQAPP-AGQPQGP 402 Score = 60.1 bits (144), Expect = 2e-08 Identities = 65/261 (24%), Positives = 92/261 (35%), Gaps = 12/261 (4%) Query: 1092 PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSIL-QTARLLPGAPQ 1150 P + + P P PP PQ PPP + S S G Q Q PG PQ Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 202 Query: 1151 QPP----KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206 PP G P + ++++A + +G + P Sbjct: 203 GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGK 262 Query: 1207 SEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266 + P G KP+ P PP P+ PPP+ + + + GKP P Q Q Sbjct: 263 PQGPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 321 Query: 1267 PPETSVEAPPVVTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGAS----VP 1320 P + P P+ PP P KP+ P G + R + P + PP + P Sbjct: 322 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP 381 Query: 1321 PPLEAPPLVPKVPPRRKKSAP 1341 PP P P+ PP + P Sbjct: 382 PPAGGNPQQPQAPPAGQPQGP 402 Score = 56.2 bits (134), Expect = 2e-07 Identities = 67/286 (23%), Positives = 90/286 (31%), Gaps = 43/286 (15%) Query: 1184 LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTL 1243 L + +E+ +P + + + P G KP+ P +PP P+ PPP+ + Sbjct: 13 LSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPP 72 Query: 1244 RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP-KPRTFQPGKAAERPS 1302 GKP P PP+ P+ PP P KP+ P R Sbjct: 73 PPPGKPQGP--------------PPQGG-------NKPQGPPPPGKPQGPPPQGDKSRSP 111 Query: 1303 HRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYN 1362 P + PP G + P PP P+ PP + + P Sbjct: 112 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171 Query: 1363 SSDSPSGH---PPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLL 1419 SS SP G PP G PQG P G KP+ P G Q P Sbjct: 172 SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGP----- 224 Query: 1420 HHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPP 1465 D RSP P P G + + PP Sbjct: 225 -----------PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259 Score = 47.4 bits (111), Expect = 1e-04 Identities = 41/152 (26%), Positives = 55/152 (36%), Gaps = 7/152 (4%) Query: 1092 PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSIL-QTARLLPGAPQ 1150 P + + P P PP PQ PPP G + S S G Q Q PG PQ Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210 PP G +KP + + +R S P+ + + Sbjct: 327 GPPPQ--GGNKPQGPPPPGKPQGPPPQGGSK----SRSARSPPGKPQGPPQQEGNNPQGP 380 Query: 1211 PTPGAAKPETPQAPPLLPRRPPPRVPAIKKPT 1242 P P P+ PQAPP + PPR P +P+ Sbjct: 381 PPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPS 412 >gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens] Length = 816 Score = 64.3 bits (155), Expect = 8e-10 Identities = 96/367 (26%), Positives = 131/367 (35%), Gaps = 62/367 (16%) Query: 1045 PGPTALA-PPSKSP--ALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSV--- 1098 P P+A PP++ P +++ +H T + R + G R SRSLS Sbjct: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSP----AARRRPSAGGGLQRPASRSLSSSAT 238 Query: 1099 ----PNRPRP-----PQPPQRP--PPPTGLM------VKKSASDASISSGTHGQYSILQT 1141 P R P P+ P P P P GL V DA+ + G + Sbjct: 239 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 298 Query: 1142 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR 1201 + P +P PP +T S P TT+ G + +A + P Sbjct: 299 SPSAPPSPSAPPSLQTLPSPPATPPSQATTSL--------------GSPTLQATHSFLP- 343 Query: 1202 DLEASSEPEPTPGAAKPETPQAPPLL---PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQ 1258 P +P A P PQAPP L P + PP PA + T P +P Sbjct: 344 ------SPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395 Query: 1259 QTVHFTIGPPETSVEAP-PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGA 1317 PP V+AP +P V P P + P A P P+ +PP + + Sbjct: 396 LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 455 Query: 1318 SVPPPL-----EAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372 + PPP APPL PP + A A LQ L S G + SPS P Sbjct: 456 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG---QAPFSPSASLP 512 Query: 1373 AAGTVFP 1379 + P Sbjct: 513 MSPLATP 519 Score = 58.2 bits (139), Expect = 6e-08 Identities = 80/338 (23%), Positives = 111/338 (32%), Gaps = 26/338 (7%) Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVEL-KRELEAVGEFRHRSPSRSLSVPNRPR 1103 P P+A PS P+L P L L+A F P L+ P Sbjct: 298 PSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357 Query: 1104 PPQ----PPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159 PP P Q PP P + S + +LQ P +P Sbjct: 358 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219 S P + + A + AA + AS P TP P Sbjct: 418 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SPSATPPPQAPP 464 Query: 1220 TPQAPPLLPRRPPPRVP-AIKKPTLRRTGKPLS--PEEQFEQQTVHFTIGPPETSV-EAP 1275 APPL +PPP+ P A+ P L+ P + P + + + P T +AP Sbjct: 465 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 524 Query: 1276 PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335 PV+ AP + P P +A RP P + + P ++ P PP P P Sbjct: 525 PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPS 581 Query: 1336 RKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372 S P A H S + L+G + PP Sbjct: 582 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 619 Score = 50.8 bits (120), Expect = 1e-05 Identities = 101/424 (23%), Positives = 137/424 (32%), Gaps = 71/424 (16%) Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASIS-------SGTHGQYSILQTA-RLLPGAPQQPP 1153 PRPP P+ PPP T ++ + ++ +G G +I ++A R P +PP Sbjct: 27 PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86 Query: 1154 KARTG-------------ISKPYNVKQIKTTNAQEAEAAIRCLLE---ARGGASE----E 1193 + G +S P T + +R E ARG A+E Sbjct: 87 ASGRGERAPPAKNTSPGPVSSPGRASG-TTRPGPLGQKGLRISAEETVARGKATEAPKRS 145 Query: 1194 ALSAVAPRDLEASSEPEPTPGAAKPE--------TPQAPPLLPRRPPPRVP--------- 1236 ALSA A RD + P+P A+ P+ P RPP P Sbjct: 146 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205 Query: 1237 ---AIKKPTLRRT----GKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKP 1289 P RR G P + + P + A AP P PKP Sbjct: 206 HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP 265 Query: 1290 RTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP----PLVPKVPP--RRKKSAPAA 1343 + G A RP P +A P G PL P P P PP + S PA Sbjct: 266 K----GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT 321 Query: 1344 FHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPE 1403 Q S T++ SP P A P + + P Sbjct: 322 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381 Query: 1404 AAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAEL 1463 A P Q P +H LL + S P+ + P P+ P + S A L Sbjct: 382 ATP---SPQAPNALAVH---LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 435 Query: 1464 --PP 1465 PP Sbjct: 436 AAPP 439 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 62.0 bits (149), Expect = 4e-09 Identities = 73/278 (26%), Positives = 111/278 (39%), Gaps = 40/278 (14%) Query: 1090 RSPSRSLSVPNRPRPPQPPQRP--PPPTGLMVKKSASDASISSGTHGQYSILQTARL--L 1145 ++ S L+ P+ PP P P PP+ L + +SI++ L + L L Sbjct: 547 QTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGL 606 Query: 1146 PGAPQQP-----PKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200 P P P P+A ++ P ++ + A + L S +A +A+A Sbjct: 607 PSPPLSPLATPPPQAPPXLALP----PLQAPPSPPASPPLSPLATP----SPQAPNALAV 658 Query: 1201 RDLEASSEPEPTPGAAKPETPQA-PPLLPRRPPPRV--PAIKKPTLRRTGKPLSPEEQFE 1257 L+A P P+P P +P A PP+ P PP P++ P L+ P + Sbjct: 659 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 718 Query: 1258 QQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKP-----ASDEAP 1312 T PP +APP + AP + P P P + P R P + P Sbjct: 719 SAT------PPP---QAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVP 769 Query: 1313 PGAGASVP------PPLEAPPLVPKVPPRRKKSAPAAF 1344 P AS+P PP +APP + P + S PA+F Sbjct: 770 PSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASF 807 Score = 60.5 bits (145), Expect = 1e-08 Identities = 89/374 (23%), Positives = 129/374 (34%), Gaps = 81/374 (21%) Query: 1081 LEAVGEFRHRSPSR---SLSVPNRPR---PPQPPQRPP------PPTGLMVKKSASDASI 1128 L+A F SP + SL+ P+RP P PP + P PP + + S S Sbjct: 423 LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482 Query: 1129 SSGTHGQYSILQTARLLPGAP-----QQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCL 1183 H ++ A P AP P + ++ ++ P ++T A + Sbjct: 483 PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPP----SLQTPPASLTTPPL--- 535 Query: 1184 LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETP-----QAPPLLPRRPPPRV--- 1235 E L ++AP L+ +S P TP P P QAPP PPP Sbjct: 536 ---------ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSS 586 Query: 1236 ---------PAIKKPTLR-RTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPP 1285 PA+ P L+ PLSP Q PP + +PP +P + P Sbjct: 587 IATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPP--ASPPLSP 644 Query: 1286 VPKPRTFQPGKAA-----------ERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPP 1334 + P P A P + P S A P S PP +APP + P Sbjct: 645 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 704 Query: 1335 RRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDS 1394 + S PA+ ++ +++ P PP A + S SP Sbjct: 705 QVPPSPPAS-------------PPMSPSATPPPQAPPPLAAPPLQ----VPPSPPASPPM 747 Query: 1395 DGTKAMKPEAAPLL 1408 + P PLL Sbjct: 748 SPSATPPPRVPPLL 761 Score = 55.5 bits (132), Expect = 4e-07 Identities = 69/278 (24%), Positives = 97/278 (34%), Gaps = 49/278 (17%) Query: 1104 PPQPPQRPPP--PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPK-ARTGIS 1160 PP P PPP P+ + + +++S + L PQ PP A + Sbjct: 572 PPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQ 631 Query: 1161 KPYN------VKQIKTTNAQEAEAAIRCLLEA----------RGGASEEALSAVAPRDLE 1204 P + + + T + Q A LL+A + S A V+P Sbjct: 632 APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 691 Query: 1205 ASSEPE----------PTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEE 1254 S P P+P A+ P +P A P PP P ++ P P+SP Sbjct: 692 PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSA 751 Query: 1255 QFEQQTVHFTIGPP-----------------ETSVEAPPVVTAPRVPPVPKPRTFQPGKA 1297 + PP + +APP + P + +P P PG+A Sbjct: 752 TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQA 811 Query: 1298 AERPSHRKPASDEAPPGAGASVPPPLEAPPL-VPKVPP 1334 PS P S A P A PP L AP L VP PP Sbjct: 812 PFSPSASLPMSPLATPPPQA--PPVLAAPLLQVPPSPP 847 Score = 50.8 bits (120), Expect = 1e-05 Identities = 92/375 (24%), Positives = 134/375 (35%), Gaps = 68/375 (18%) Query: 1091 SPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 +P RS R P P P+ M ++S + +GT + R P A Sbjct: 150 APKRSALSAGARRDTSGPT-PGTPSPAMARRSRA-----AGTE-----VGLPRPAPSARP 198 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210 +PP G K +V + E A R A GG L A R L +S+ P Sbjct: 199 RPPTE--GPRK--SVSSASEHSTTEPSPAARRRPSAGGG-----LQRPASRSLSSSATPL 249 Query: 1211 PTPGAAKPE---TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGP 1267 +P + P TP+AP + P + A++ P + K +P +GP Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP-----------ALGP 298 Query: 1268 PETSVEAPPVVTAPRVPPVPKP--------RTFQPGKAAERPSHRKPASDEAPP------ 1313 +S A P + + PVP P T P P P S APP Sbjct: 299 LSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLP 358 Query: 1314 ---------GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSS 1364 + PP++APP + +PP + + + LQ S L S Sbjct: 359 SPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL 418 Query: 1365 DSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKL 1424 SP+ A + + +S TSP + P++ PL Q P +L P L Sbjct: 419 GSPT--LQATHSFLTMSPRQTQASLTSPSRPA--STPPDSPPL----QAPL-SLPASPPL 469 Query: 1425 LNNTWLSKSSDPLDS 1439 T LS + PL S Sbjct: 470 --QTSLSPAVSPLSS 482 Score = 49.3 bits (116), Expect = 3e-05 Identities = 68/291 (23%), Positives = 100/291 (34%), Gaps = 38/291 (13%) Query: 1096 LSVPNRPRPPQPPQRPP--PPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153 L P P PP PP + P PP V SA+ S + + + ++ P P PP Sbjct: 661 LQAPFSP-PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL----QVPPSPPASPP 715 Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213 + + P + Q + A P A+ P P Sbjct: 716 MSPSATPPPQAPPPLAAPPLQVPPSP----------------PASPPMSPSATPPPRVPP 759 Query: 1214 GAAKP--ETPQAPPL------LPRRPPPRVPAIKKPTLRRTGKPLS--PEEQFEQQTVHF 1263 A P + P +PP L + PP PA+ P L+ P + P + + Sbjct: 760 LLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 819 Query: 1264 TIGPPETSV-EAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322 + P T +APPV+ AP + P P +A RP P + + P ++ P Sbjct: 820 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP- 878 Query: 1323 LEAPPLVPKVPPRRKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372 PP P P S P A H S + L+G + PP Sbjct: 879 --GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 927 Score = 42.0 bits (97), Expect = 0.004 Identities = 97/383 (25%), Positives = 135/383 (35%), Gaps = 95/383 (24%) Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGA--PQQPPKARTGI 1159 PRPP P RPPPP V +A ++G G+ + + A + GA P+ P+A Sbjct: 27 PRPPGSP-RPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA---- 77 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219 ++ A R RG AP S P +PG A Sbjct: 78 ------GPTRSAGTSSRNPASRPPASGRGER--------APPAKNTSPGPVSSPGRASGT 123 Query: 1220 TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEA-PPVV 1278 T RP P L + G +S EE + T P +++ A Sbjct: 124 T---------RPGP---------LGQKGLRISAEETVARGKA--TEAPKRSALSAGARRD 163 Query: 1279 TAPRVPPVPKPRTFQPGKAA------ERPSHRKPASDEAPP--GAGASVPPPLEAPPLVP 1330 T+ P P P + +AA RP+ P++ PP G SV E P Sbjct: 164 TSGPTPGTPSPAMARRSRAAGTEVGLPRPA---PSARPRPPTEGPRKSVSSASEHSTTEP 220 Query: 1331 KVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSAT 1390 RR+ SA +S L T SS + SG P A GT P+ + + + Sbjct: 221 SPAARRRPSAGGGLQRPASRS---LSSSATPLSSPARSG-PSARGT--PR----APAHPS 270 Query: 1391 SPDSDGTKAMKP--------EAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTR 1442 P G +A++P +AAP LG S + P SGT Sbjct: 271 QPKPKGLQALRPPQVTPPRKDAAPALGPLSS-----------------SPLATPSPSGT- 312 Query: 1443 SPKRDPIDPVSAGASAAKAELPP 1465 K P+ P A+ A LPP Sbjct: 313 --KARPVPPPDNAATPLPATLPP 333 Score = 31.2 bits (69), Expect = 7.8 Identities = 75/286 (26%), Positives = 100/286 (34%), Gaps = 47/286 (16%) Query: 1051 APPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSP-SRSLSVPNRPRPPQPPQ 1109 +PP+ P K P L+ F ++P S S S+P P PPQ Sbjct: 771 SPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830 Query: 1110 RPPPPTGLMVKKSAS-------DASISSGTHGQYSILQTARL-LPGAPQQPPKARTGISK 1161 PP +++ S A T G + + RL L AP PP S Sbjct: 831 APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 890 Query: 1162 PYNVKQIKTTNAQEAEAAIRCLLEARG--GASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219 + + A + +A E RG E +A P D E ++ P + P Sbjct: 891 TLSGPDL----AGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA-CHPAAWSRGPA 945 Query: 1220 TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVT 1279 P A P P P PA TG P T++ T G PE++ AP Sbjct: 946 PPLAFRGAPGAPLPWPPA--------TG----PGSADGLCTIYETEG-PESATPAPGA-- 990 Query: 1280 APRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEA 1325 + P P P T GKAA A GAGAS P +A Sbjct: 991 ---LDPGPSPGT-SGGKAA------------AGAGAGASSRSPKQA 1020 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 60.5 bits (145), Expect = 1e-08 Identities = 73/277 (26%), Positives = 102/277 (36%), Gaps = 41/277 (14%) Query: 1093 SRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQP 1152 S + P +P P++ PP V K +++ +P P+ P Sbjct: 10446 SEKIIPPKKPPTKVVPRKEPPAKVPEVPKKI--------------VVEEKVRVPEEPRVP 10491 Query: 1153 PKARTGISKPYNV---KQIKTTNAQEAEAAIRCLLEA-RGGASEEALSAVAPRDLEASSE 1208 P + P V K++ A++ EA + EA + E+ + P+ E Sbjct: 10492 PTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT 10551 Query: 1209 PEP-TPGAAKPE--TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI 1265 P P AA PE P+A P P PPP VP K + P +P ++ E V Sbjct: 10552 KVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPE 10611 Query: 1266 GP----PETSVEAP----PVVTAPRVPPVPK---PRTFQPGKAAERPSHRKPASDEAPPG 1314 P PE V P P V +VP VPK P P +P P E P Sbjct: 10612 APKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEE 10671 Query: 1315 AGASVPP------PLEAPPLVPKVPPRR---KKSAPA 1342 PP P A P VPP++ +K APA Sbjct: 10672 VALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPA 10708 Score = 58.9 bits (141), Expect = 4e-08 Identities = 93/383 (24%), Positives = 147/383 (38%), Gaps = 75/383 (19%) Query: 998 EENFDFTSLDYESEGDILEDDEDY-LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKS 1056 EE ++ DY+ E + E E+Y +E+ + E + +++ P + P + Sbjct: 9743 EEYEEYEEYDYK-EFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEE 9801 Query: 1057 PALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTG 1116 P TK K P K +AV E + P +P + +PP PP+ P P Sbjct: 9802 PVPTKPKAPPA----------KVLKKAVPEEKVPVP-----IPKKLKPP-PPKVPEEPKK 9845 Query: 1117 LMVKKSASDASISSGTHGQYSILQTARLLPGAP------QQPPKARTGISKPYNVKQIK- 1169 + +K IS + + + A +P P ++ P R ++ P V ++ Sbjct: 9846 VFEEK----IRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPK 9901 Query: 1170 -------------TTNAQE--AEAAIRCLLEARGGASEEALSAVAPRDLE------ASSE 1208 T+ +E E + E +EE + V P + E Sbjct: 9902 ELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEE 9961 Query: 1209 PEPTPGAAKPETPQAP-PLLPRRPPPRVPAI--KKPTLRRTGKPLSPEEQFEQQTVHFTI 1265 +P P K E P A P +P++P +VP + KK P P++ ++ V Sbjct: 9962 KKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPV-- 10019 Query: 1266 GPPETSVEAPPVVTAPRVPP---------VPKPRTFQ--PGKAAERPSHRKPASDEAPPG 1314 P VEAPP P VP VP P+ + P K E P P + P Sbjct: 10020 -PVPKKVEAPPA-KVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTP- 10076 Query: 1315 AGASVPPPLEAPPLVPKVPPRRK 1337 VP +EAPP PKVP +R+ Sbjct: 10077 ----VPKKVEAPP--PKVPKKRE 10093 Score = 56.2 bits (134), Expect = 2e-07 Identities = 74/320 (23%), Positives = 112/320 (35%), Gaps = 54/320 (16%) Query: 1052 PPSKSPALTK----KKQHPTY---KDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRP 1104 PP+K P + K +K+ P K ++ E+ E E V P+ + P P Sbjct: 10633 PPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVA--LEEPPAEVVEEPEPAAP 10690 Query: 1105 PQ---PPQRPPP----PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157 PQ PP++P P P + K + + ++P P+ PP Sbjct: 10691 PQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVP 10750 Query: 1158 GISK-----------------PYNVKQIKTTNAQEAEAAIRCLLEARGGASE--EALSAV 1198 + K P V ++ E + A+ A E E + Sbjct: 10751 EVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEI 10810 Query: 1199 APRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQ 1258 AP + A E +P P A + E PP +P P +P K P +++ P E + Sbjct: 10811 APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPE--- 10867 Query: 1259 QTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGAS 1318 PE +E P + P PP P+ K + + K E P Sbjct: 10868 ---------PEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKP-----Q 10913 Query: 1319 VPPPLEAPPLVPKVPPRRKK 1338 VP +E PL KVP KK Sbjct: 10914 VPEKVELTPL--KVPGGEKK 10931 Score = 55.8 bits (133), Expect = 3e-07 Identities = 78/332 (23%), Positives = 122/332 (36%), Gaps = 63/332 (18%) Query: 1008 YESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPT 1067 YE +I ++E +E P + E + P + P K P + K + P Sbjct: 10804 YEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPP 10863 Query: 1068 YKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDAS 1127 + + + V K +L +PRPP PP P PP + +K + Sbjct: 10864 KEPEPEKVIEKPKL-------------------KPRPPPPP--PAPPKEDVKEKIFQLKA 10902 Query: 1128 ISSGTHGQYSILQTARLLPGAPQQPPKAR-TGISKPYNVKQIKTTNAQ-----EAEAAIR 1181 I + +P PQ P K T + P K+++ + + E ++ Sbjct: 10903 IPK------------KKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLK 10950 Query: 1182 CLLEARGGASEEALSAVAPRDLEASSEPE-PTPGAAKPETPQAPPLLPRRP-----PPRV 1235 +L R EE V P+ LE +P P P KP P + +R P +V Sbjct: 10951 SVLRKR---PEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKV 11007 Query: 1236 PAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPG 1295 P IK P + P+ + E +T+ PP E P+ VP V G Sbjct: 11008 PEIK-PAIPLPAPEPKPKPEAEVKTIK----PPPVEPEPTPIAAPVTVPVV--------G 11054 Query: 1296 KAAERPSHRKPASDEAPP--GAGASVPPPLEA 1325 K AE + ++ A+ P G P P+EA Sbjct: 11055 KKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEA 11086 Score = 54.3 bits (129), Expect = 9e-07 Identities = 66/261 (25%), Positives = 93/261 (35%), Gaps = 57/261 (21%) Query: 1092 PSRSLSVPNRPRPPQPPQRPPP-PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 P + + VP +P PP + P P + +K +A +P P+ Sbjct: 10534 PEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEA------------------IPPKPE 10575 Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL-EASSE- 1208 PP + EA + E + A+ V P + EA E Sbjct: 10576 SPPP-------------------EVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEV 10616 Query: 1209 -PEPTPGAAKPETPQAPPL-LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266 PE P+ P+ PP +P P VP K P P E FE+ Sbjct: 10617 VPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEE 10676 Query: 1267 PPETSVE-----APPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP 1321 PP VE APP VT P PVP+ + P A++P E PP VP Sbjct: 10677 PPAEVVEEPEPAAPPQVTVPPKKPVPEKKA--PAVVAKKP--------ELPPVKVPEVPK 10726 Query: 1322 PLEAPPLVPKVPPRRKKSAPA 1342 + VP V P++ ++ PA Sbjct: 10727 EVVPEKKVPLVVPKKPEAPPA 10747 Score = 52.8 bits (125), Expect = 3e-06 Identities = 74/310 (23%), Positives = 119/310 (38%), Gaps = 30/310 (9%) Query: 1044 VPGPTA-LAPPSKSPALTKKKQHPTYKDDADLVELKRE--LEAVGEFRHRS--------- 1091 VP P +APP + P + K+ + + ++V E +E E+ H Sbjct: 9883 VPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEV 9942 Query: 1092 -PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150 P + VP PR P P ++ P P + KK A A + + L+P + Sbjct: 9943 VPVIPVKVPEVPRKPVPEEKKPVP--VPKKKEAPPAKVPEVPKKPEEKVPV--LIPKKEK 9998 Query: 1151 QPP-KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEA-RGGASEEALSAVAPRDLEASSE 1208 PP K KP +++ ++ EA + E + E+ + AP+ +EA Sbjct: 9999 PPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPA 10058 Query: 1209 PEP-TPGAAKPETPQAPPLLPRR---PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264 P P PE + P+ P++ PPP+VP ++P P E FE++ V Sbjct: 10059 KVPEVPKKLIPEEKKPTPV-PKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIV--- 10114 Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRK-PASDEAPPGAGASVPPPL 1323 P E + V +P+ P + P + P +E P VP Sbjct: 10115 --PEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEE 10172 Query: 1324 EAPPLVPKVP 1333 P + PKVP Sbjct: 10173 VLPEVKPKVP 10182 Score = 51.6 bits (122), Expect = 6e-06 Identities = 62/208 (29%), Positives = 82/208 (39%), Gaps = 22/208 (10%) Query: 1146 PGAPQQPPKARTGI----SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEA------L 1195 P AP + P+ I P V K A+ E + ++E + EE + Sbjct: 10436 PKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKV 10495 Query: 1196 SAVAPRDLEASSEPEPTPGAAKPET-----PQAP-PLLPRRPPPRVPAIKKPTLRRTGKP 1249 V P + P P A KPE P+AP ++P + P VP KKP + T P Sbjct: 10496 PEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVP-VPPPKKPEVPPTKVP 10554 Query: 1250 LSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPR-VPPVPKPRTFQPGKAAERPSHRKPAS 1308 P+ ++ V I PP+ P V AP+ V P K P K P A Sbjct: 10555 EVPKAAVPEKKVPEAI-PPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAP 10613 Query: 1309 DEAPPGAGASVPPPL--EAPPL-VPKVP 1333 E P VPPP E PP VP+VP Sbjct: 10614 KEVVPEKKVPVPPPKKPEVPPTKVPEVP 10641 Score = 48.9 bits (115), Expect = 4e-05 Identities = 40/143 (27%), Positives = 54/143 (37%), Gaps = 11/143 (7%) Query: 1209 PEPTPGAAKPETPQAPPLLPRRPPPR----VPAIKK-----PTLRRTGKPLSPEEQFEQQ 1259 P P P +P P+ P + P++P P VP KK P + K PEE+ Sbjct: 9302 PVPIPKKVEPPAPKVPEV-PKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP 9360 Query: 1260 TVHFTIGPPETSVEAPP-VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGAS 1318 PP E VVT ++ V + P E P + P + P Sbjct: 9361 VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEE 9420 Query: 1319 VPPPLEAPPLVPKVPPRRKKSAP 1341 VPPP + P L K P K + P Sbjct: 9421 VPPPPKVPALPKKPVPEEKVAVP 9443 Score = 48.1 bits (113), Expect = 6e-05 Identities = 63/291 (21%), Positives = 105/291 (36%), Gaps = 26/291 (8%) Query: 1062 KKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP-PQRPPPPTGLMVK 1120 ++ PT + D +RE E E +P +P P +P P +P P ++K Sbjct: 9757 EEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLK 9816 Query: 1121 KSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAI 1180 K+ + + + +L P P+ P + + + + K Q E A Sbjct: 9817 KAVPEEKVP--------VPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAA 9868 Query: 1181 RCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETP-QAPPLLPRRPPPRVPAIK 1239 + ++ + +EE + PR E P PE P + P V ++ Sbjct: 9869 KVPMKPKRVVAEEKVPV--PRK-------EVAPPVRVPEVPKELEPEEVAFEEEVVTHVE 9919 Query: 1240 KPTLRRTGKPLSPEEQFEQQTVHFTIGPPET-SVEAPPVVTAPRVPPVPKPRTFQPGKAA 1298 + + + + EE+F + + P + V PV + PVPK + P K Sbjct: 9920 EYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVP 9979 Query: 1299 E---RPSHRKPA---SDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAA 1343 E +P + P E PP A P P VP +K AP A Sbjct: 9980 EVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPA 10030 Score = 43.9 bits (102), Expect = 0.001 Identities = 40/134 (29%), Positives = 52/134 (38%), Gaps = 17/134 (12%) Query: 1219 ETPQAPPLLPRRPPPRVPAIKKPT--LRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPP 1276 E P+APP P +P K PT + R P E ++ V + PE P Sbjct: 10434 EKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPE-----EP 10488 Query: 1277 VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPL-------EAPPLV 1329 V +VP V P+ P K P +KP EAPP P + PP Sbjct: 10489 RVPPTKVPEVLPPKEVVPEKKVPVPPAKKP---EAPPPKVPEAPKEVVPEKKVPVPPPKK 10545 Query: 1330 PKVPPRRKKSAPAA 1343 P+VPP + P A Sbjct: 10546 PEVPPTKVPEVPKA 10559 Score = 43.1 bits (100), Expect = 0.002 Identities = 43/153 (28%), Positives = 60/153 (39%), Gaps = 18/153 (11%) Query: 1193 EALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP 1252 E + + R E + P +K PQ P P + V +K P + +S Sbjct: 9187 EKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQE--EVIEVKVPAVHTKKMVISE 9244 Query: 1253 EEQF----EQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPAS 1308 E+ F ++ V T+ PE E +VT ++ R P K E P KPA Sbjct: 9245 EKMFFASHTEEEVSVTV--PEVQKE---IVTEEKIHVAISKRVEPPPKVPELPE--KPAP 9297 Query: 1309 DEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341 +E P VP P + P PKVP KK P Sbjct: 9298 EEVAP-----VPIPKKVEPPAPKVPEVPKKPVP 9325 Score = 42.0 bits (97), Expect = 0.004 Identities = 77/329 (23%), Positives = 122/329 (37%), Gaps = 63/329 (19%) Query: 1044 VPGPTAL-APPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRP 1102 VP P + APP+K P + KK ++ + +++EA P Sbjct: 10047 VPAPKKVEAPPAKVPEVPKK----LIPEEKKPTPVPKKVEA------------------P 10084 Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKP 1162 P P +R P P + + + + + + +LP + P+ + + Sbjct: 10085 PPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEE 10144 Query: 1163 YNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQ 1222 + + E E E EE L V P+ P P P K T + Sbjct: 10145 EEIPPEEEEVPPEEEYVPE---EEEFVPEEEVLPEVKPK----VPVPAPVPEIKKKVT-E 10196 Query: 1223 APPLLPRR---PPPRVPAI-KKPTLRRTGKPLSPE-------EQFEQQTVHFTIGPPET- 1270 ++P++ PP +VP + KK +R P E E+ E++ + P E Sbjct: 10197 KKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP 10256 Query: 1271 SVEAPPVVTAPRVP------------PVPKPRTFQPGKAAER-PSHRKPA---SDEAPPG 1314 S+E V PRVP PVPK P K +++ P + P EAPP Sbjct: 10257 SIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPA 10316 Query: 1315 AGASVPPPL-EAPPLVPK---VPPRRKKS 1339 VP + E LVPK VPP + ++ Sbjct: 10317 KVPEVPKKVPEKKVLVPKKEAVPPAKGRT 10345 Score = 41.2 bits (95), Expect = 0.008 Identities = 81/352 (23%), Positives = 130/352 (36%), Gaps = 71/352 (20%) Query: 1044 VPGPTAL---APPSKSPALTK------KKQHPTYKDDAD---LVELKRELEAVGEFRHRS 1091 +P P A APP+K P + K K T ++++ + E+ ++ V E R Sbjct: 9357 IPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKK--KVPEERKPV 9414 Query: 1092 PSRSLSVPNRPRPPQPPQRPPP------PTGLMVKKSASDASISSGT-HGQYSILQTARL 1144 P + VP P+ P P++P P P + K A +S T + + +L Sbjct: 9415 PRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKL 9474 Query: 1145 LPGAPQQPPKARTGIS-----------KPYNVKQIKTTNAQEAEAA----IRCLLEARGG 1189 PQ+ R +S + ++ + +E E A + E Sbjct: 9475 SFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEY 9534 Query: 1190 ASEEALSAVAPRDLEASSEPEPTPGAAKPE-----TPQAPPLLPRRPPPRVPAIKKPTL- 1243 EE L ++ R E EP + E P+ P + PP +VP K + Sbjct: 9535 VVEEKLHIISKR-----VEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVP 9589 Query: 1244 -RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPP-VPKPRTFQPGKAAERP 1301 ++ P+ +E+ + PP+ E V +VPP V K P K ER Sbjct: 9590 EKKVPAPVPKKEK---------VPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTER- 9639 Query: 1302 SHRKPASD----------EAPPGAGASVPPPLEAP-PLVPKVPPRRKKSAPA 1342 H + + EAPP A P P V K+ P+R++ PA Sbjct: 9640 -HMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPA 9690 Score = 40.4 bits (93), Expect = 0.013 Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 11/117 (9%) Query: 1203 LEASSEPEPTPGAAKPETPQAPPLLPRRP---PPRVPAIKKPTLRRTGKPL-----SPEE 1254 +E + EPE P ++ E P+ PP + PPRVP + K + P+ +P Sbjct: 10235 VEVTEEPEEEP-ISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPA 10293 Query: 1255 QFEQQTVHFTIGPPETSVEAPPVVTAPRVP-PVPKPRTFQPGKAAERPSHRKPASDE 1310 + ++ + P EAPP P VP VP+ + P K A P+ + +E Sbjct: 10294 KVSKKIPEEKVPVPVQKKEAPP-AKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEE 10349 Score = 38.9 bits (89), Expect = 0.038 Identities = 78/385 (20%), Positives = 125/385 (32%), Gaps = 98/385 (25%) Query: 1039 DDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSV 1098 ++++ VP P + PP+ KK P K + + + P+ V Sbjct: 9298 EEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPK-------------KEPAAPPKV 9344 Query: 1099 PNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHG----QYSILQTAR------LLPGA 1148 P P+ P P ++ P P + KK A A + G + + T R +P Sbjct: 9345 PEVPKKPVPEEKIPVP--VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEI 9402 Query: 1149 PQQ------------------PPKARTGISKPYNVKQI-------KTTNAQEAEAAIRCL 1183 P++ PPK KP +++ K AE + + + Sbjct: 9403 PKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTV 9462 Query: 1184 LEARGGASEEALSAVAPRDLEAS----------SEPEPTPGAA----------KPETPQA 1223 +E + +EE LS P+ +E + S E G + + E + Sbjct: 9463 VEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEV 9522 Query: 1224 PPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPP-ETSVEAPPVVTAPR 1282 P +K + P E E+Q + P +E PP P Sbjct: 9523 TEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPE 9582 Query: 1283 VP-----------PVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPK 1331 P PVPK P K E P +KP ++ P + PL A K Sbjct: 9583 APKKIVPEKKVPAPVPKKEKVPPPKVPEEP--KKPVPEKKVPPKVIKMEEPLPA-----K 9635 Query: 1332 VPPRRKKSAPAAFHLQVLQSNSQLL 1356 V R H+Q+ Q L+ Sbjct: 9636 VTER---------HMQITQEEKVLV 9651 Score = 37.0 bits (84), Expect = 0.14 Identities = 75/354 (21%), Positives = 125/354 (35%), Gaps = 56/354 (15%) Query: 1010 SEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSD-----------VPGPTALAPPSKSPA 1058 +E +++E+ E+Y+V+E E ++++ +P PP+K P Sbjct: 9523 TEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPE 9582 Query: 1059 LTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM 1118 KK +V K+ V + P + VP P+ P P ++ PP + Sbjct: 9583 APKK-----------IVPEKKVPAPVPKKEKVPPPK---VPEEPKKPVPEKKVPPK---V 9625 Query: 1119 VKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNV---KQIKTTNAQE 1175 +K + + H Q + + + + PPKAR V K +K +E Sbjct: 9626 IKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKRE 9685 Query: 1176 AEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRV 1235 E + + EE +S AP+ EP+P E + L V Sbjct: 9686 EEPPAKVTEFRKRVVKEEKVSIEAPK-----REPQPIKEVTIMEEKERAYTLEEE---AV 9737 Query: 1236 PAIKKPTLR-------RTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVP---- 1284 ++ + + P E+++Q + E E +T P P Sbjct: 9738 SVQREEEYEEYEEYDYKEFEEYEPTEEYDQYE-EYEEREYERYEEHEEYITEPEKPIPVK 9796 Query: 1285 PVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKK 1338 PVP+ KA +K +E P VP P + P PKVP KK Sbjct: 9797 PVPEEPVPTKPKAPPAKVLKKAVPEEKVP-----VPIPKKLKPPPPKVPEEPKK 9845 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 60.5 bits (145), Expect = 1e-08 Identities = 82/322 (25%), Positives = 117/322 (36%), Gaps = 55/322 (17%) Query: 1090 RSPSRSLSVPNRPRPP-----QPPQRPPP------------------PTGLMVKKSASDA 1126 R R+ + P++P+P +PPQ PP P+ +S + Sbjct: 260 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP 319 Query: 1127 SISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEA 1186 ++ + H Q A LP AP P S P +++ + + A A L Sbjct: 320 TLPATPHSSSLTCQLATPLPLAPPSP-------SAPPSLQTLPSPPATPPSQATTSL--- 369 Query: 1187 RGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL---PRRPPPRVPAIKKPTL 1243 G + +A + P P +P A P PQAPP L P + PP PA + Sbjct: 370 -GSPTLQATHSFLP-------SPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSP 419 Query: 1244 RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAP-PVVTAPRVPPVPKPRTFQPGKAAERPS 1302 T P +P PP V+AP +P V P P + P A P Sbjct: 420 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 479 Query: 1303 HRKPASDEAPPGAGASVPPPL-----EAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQ 1357 P+ +PP + ++ PPP APPL PP + A A LQ L S Sbjct: 480 QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539 Query: 1358 GLTYNSSDSPSGHPPAAGTVFP 1379 G + SPS P + P Sbjct: 540 G---QAPFSPSASLPMSPLATP 558 Score = 57.4 bits (137), Expect = 1e-07 Identities = 82/338 (24%), Positives = 112/338 (33%), Gaps = 28/338 (8%) Query: 1047 PTALAPPSKS--PALTKKKQHPTYKDDADLVEL-KRELEAVGEFRHRSPSRSLSVPNRPR 1103 P LAPPS S P+L P L L+A F P L+ P Sbjct: 337 PLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396 Query: 1104 PPQ----PPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159 PP P Q PP P + S + +LQ P +P Sbjct: 397 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 456 Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219 S P + + A + AA + AS P TP P Sbjct: 457 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SPSATPPPQAPP 503 Query: 1220 TPQAPPLLPRRPPPRVP-AIKKPTLRRTGKPLS--PEEQFEQQTVHFTIGPPETSV-EAP 1275 APPL +PPP+ P A+ P L+ P + P + + + P T +AP Sbjct: 504 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 563 Query: 1276 PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335 PV+ AP + P P +A RP P + + P ++ P PP P P Sbjct: 564 PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPS 620 Query: 1336 RKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372 S P A H S + L+G + PP Sbjct: 621 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 658 Score = 43.9 bits (102), Expect = 0.001 Identities = 92/385 (23%), Positives = 123/385 (31%), Gaps = 89/385 (23%) Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGA--PQQPPKA---- 1155 PRPP P RPPPP V +A ++G G+ + + A + GA P+ P+A Sbjct: 27 PRPPGSP-RPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTR 81 Query: 1156 ------RTGISKP------YNVKQIKTTN----------------AQEAEAAIRCLLE-- 1185 R S+P K T+ + +R E Sbjct: 82 SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141 Query: 1186 -ARGGASE----EALSAVAPRDLEASSEPEPTPGAAKPE--------TPQAPPLLPRRPP 1232 ARG A+E ALSA A RD + P+P A+ P+ P RPP Sbjct: 142 VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 201 Query: 1233 PRVP------------AIKKPTLRRT----GKPLSPEEQFEQQTVHFTIGPPETSVEAPP 1276 P P RR G P + + P + A Sbjct: 202 TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARG 261 Query: 1277 VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPL-----------EA 1325 AP P PKP+ G A RP P +A P G PL +A Sbjct: 262 TPRAPAHPSQPKPK----GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQA 317 Query: 1326 PPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385 PP +P P + A L + + L + SP PP+ T L Sbjct: 318 PPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSL--QTLPSPPATPPSQATTSLGSPTLQ 375 Query: 1386 T--SSATSPDSDGTKAMKPEAAPLL 1408 S SP P+A P L Sbjct: 376 ATHSFLPSPPLSPLATPPPQAPPAL 400 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 63,866,620 Number of Sequences: 37866 Number of extensions: 3423158 Number of successful extensions: 34350 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 172 Number of HSP's successfully gapped in prelim test: 1175 Number of HSP's that attempted gapping in prelim test: 20298 Number of HSP's gapped (non-prelim): 9385 length of query: 1496 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1381 effective length of database: 13,892,928 effective search space: 19186133568 effective search space used: 19186133568 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.