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Search of human proteins with 26190608
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26190608 synaptojanin 2 [Homo sapiens]
(1496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26190608 synaptojanin 2 [Homo sapiens] 3025 0.0
gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 1187 0.0
gi|237757308 synaptojanin 1 isoform b [Homo sapiens] 1175 0.0
gi|237757310 synaptojanin 1 isoform a [Homo sapiens] 1174 0.0
gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 1171 0.0
gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso... 223 1e-57
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso... 223 1e-57
gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs... 206 1e-52
gi|190014578 suppressor of actin 1 [Homo sapiens] 190 1e-47
gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens] 179 1e-44
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas... 179 2e-44
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 155 2e-37
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 155 2e-37
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 153 1e-36
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens] 139 2e-32
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho... 129 3e-29
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H... 123 2e-27
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho... 123 2e-27
gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo sa... 105 3e-22
gi|47132519 Ras association and pleckstrin homology domains 1 is... 69 4e-11
gi|153792074 proline rich 12 [Homo sapiens] 67 1e-10
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 67 1e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 67 1e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 67 1e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 67 1e-10
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 65 5e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 64 8e-10
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 62 4e-09
gi|110349719 titin isoform N2-A [Homo sapiens] 60 1e-08
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 60 1e-08
>gi|26190608 synaptojanin 2 [Homo sapiens]
Length = 1496
Score = 3025 bits (7843), Expect = 0.0
Identities = 1496/1496 (100%), Positives = 1496/1496 (100%)
Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA
Sbjct: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL
Sbjct: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW
Sbjct: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY
Sbjct: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV
Sbjct: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH
Sbjct: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 420
WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV
Sbjct: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 420
Query: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 480
DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA
Sbjct: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 480
Query: 481 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 540
IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN
Sbjct: 481 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 540
Query: 541 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 600
GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS
Sbjct: 541 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 600
Query: 601 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 660
TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG
Sbjct: 601 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 660
Query: 661 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 720
KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY
Sbjct: 661 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 720
Query: 721 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 780
VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY
Sbjct: 721 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 780
Query: 781 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 840
KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG
Sbjct: 781 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 840
Query: 841 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 900
ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT
Sbjct: 841 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 900
Query: 901 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960
LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA
Sbjct: 901 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960
Query: 961 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 1020
VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED
Sbjct: 961 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 1020
Query: 1021 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1080
YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE
Sbjct: 1021 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1080
Query: 1081 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1140
LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ
Sbjct: 1081 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1140
Query: 1141 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200
TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP
Sbjct: 1141 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200
Query: 1201 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1260
RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT
Sbjct: 1201 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1260
Query: 1261 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1320
VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP
Sbjct: 1261 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1320
Query: 1321 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1380
PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ
Sbjct: 1321 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1380
Query: 1381 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1440
GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG
Sbjct: 1381 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1440
Query: 1441 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1496
TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT
Sbjct: 1441 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1496
>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
Length = 1526
Score = 1187 bits (3070), Expect = 0.0
Identities = 642/1400 (45%), Positives = 899/1400 (64%), Gaps = 91/1400 (6%)
Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA
Sbjct: 1 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59
Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ +
Sbjct: 60 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119
Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
+K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW
Sbjct: 120 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178
Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 179 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238
Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
+DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++
Sbjct: 239 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298
Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++
Sbjct: 299 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357
Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
+ D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP +
Sbjct: 358 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417
Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
V RF E F++MWS+NG S+SK++ G+ ALEGKAK GKLKDGARS++RTIQ+NFFD KQE
Sbjct: 418 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKAGKLKDGARSVTRTIQNNFFDSSKQE 477
Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNV 539
AI +LL+G+ ++ADK LL + +L + ++LK+M E +++ K+IR+ +GTWNV
Sbjct: 478 AIDVLLLGNTLNSDLADKARALLTTGSLRASSKVLKSMCENFYKYSKPKKIRVCVGTWNV 537
Query: 540 NGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVELSAGNIVN 598
NGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVEL+AGNIV+
Sbjct: 538 NGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVS 597
Query: 599 ASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGM 658
ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA+DTVKTGM
Sbjct: 598 ASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGM 657
Query: 659 GGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSH 718
GG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FPMGR +FSH
Sbjct: 658 GGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSH 717
Query: 719 DYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGP 778
DYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F EG + F P
Sbjct: 718 DYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAP 777
Query: 779 TYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWS 838
TYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ ++K+ +TW+
Sbjct: 778 TYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWT 837
Query: 839 PGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS 898
PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D TV+V+++S
Sbjct: 838 PGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKS 897
Query: 899 PTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKG 958
+L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL ++G ++
Sbjct: 898 -SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLN 956
Query: 959 RAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDD 1018
R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E + D +
Sbjct: 957 RTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAE 1016
Query: 1019 EDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSPALT----K 1061
+ L+ + QP S S LG +S+ P P+ PS++P+ T
Sbjct: 1017 VEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1075
Query: 1062 KKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKK 1121
+ P A + K + + E + P R ++ P R P PPQRPPPP+G +
Sbjct: 1076 AQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPPPSGR--SQ 1129
Query: 1122 SASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIR 1181
+ A ++ YS TAR P PP+A I + +A R
Sbjct: 1130 PSPQAGLAGPGPAGYS---TAR-----PTIPPRAGV----------ISAPQSHARASAGR 1171
Query: 1182 CLLEARGGASEEAL-SAVAPRDLE-------ASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233
E++ SE + S P L+ SS P P +P P A P+ P P
Sbjct: 1172 LTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQP 1231
Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQ---QTVHFTIGPPETSVEAPP-------------V 1277
+ +P R P E Q +T + G E+ ++ P
Sbjct: 1232 NLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKA 1291
Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRK 1337
+ + PVP P P + + PS ++V + P +P +P R +
Sbjct: 1292 QLSVQTSPVPTP---DPKRLIQLPS-----------ATQSNVLSSVSCMPTMPPIPARSQ 1337
Query: 1338 -----KSAPAAFHLQVLQSN 1352
+S+P F + ++N
Sbjct: 1338 SQENMRSSPNPFITGLTRTN 1357
>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
Length = 1350
Score = 1175 bits (3039), Expect = 0.0
Identities = 630/1349 (46%), Positives = 878/1349 (65%), Gaps = 81/1349 (6%)
Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA
Sbjct: 40 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 98
Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ +
Sbjct: 99 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 158
Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
+K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW
Sbjct: 159 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 217
Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 218 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 277
Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
+DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++
Sbjct: 278 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 337
Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++
Sbjct: 338 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 396
Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
+ D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP +
Sbjct: 397 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 456
Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
V RF E F++MWS+NG S+SK++ G+ ALEGKAK LKDGARS++RTIQ+NFFD KQE
Sbjct: 457 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 513
Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531
AI +LL+G+ ++ADK LL + +L V+ ++LK+M E +++ K+IR
Sbjct: 514 AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 573
Query: 532 IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590
+ +GTWNVNGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVE
Sbjct: 574 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 633
Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
L+AGNIV+ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 634 LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 693
Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710
+DTVKTGMGG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FP
Sbjct: 694 VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 753
Query: 711 MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770
MGR +FSHDYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F
Sbjct: 754 MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813
Query: 771 EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830
EG + F PTYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ +
Sbjct: 814 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 873
Query: 831 TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890
+K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D
Sbjct: 874 SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 933
Query: 891 TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950
TV+V+++S +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL
Sbjct: 934 TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 992
Query: 951 VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010
++G ++ R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E
Sbjct: 993 LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1052
Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057
+ D + + L+ + QP S S LG +S+ P P+ PS++P
Sbjct: 1053 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1111
Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113
+ T + P A + K + + E + P R ++ P R P PPQRPPP
Sbjct: 1112 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1167
Query: 1114 PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNA 1173
P+G A + T ++ + GAP P AR + P + + N
Sbjct: 1168 PSG---------ARSPAPTRKEFGGI-------GAPPSPGVARREMEAPKSPGTTRKDNI 1211
Query: 1174 QEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233
++ + + L G A P S P+ A+ A L P
Sbjct: 1212 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS------AGRLTPESQSK 1265
Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV-VTAP----------R 1282
K T +PL P+ F Q+ ++ PP ++ P V V AP
Sbjct: 1266 TSETSKGSTF--LPEPLKPQAAFPPQS---SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1320
Query: 1283 VPPVPKPRTFQ----PGKAAERPSHRKPA 1307
PP P PR+ P +A+ +P +P+
Sbjct: 1321 TPPQPPPRSRSSHSLPSEASSQPQQEQPS 1349
Score = 35.0 bits (79), Expect = 0.54
Identities = 47/200 (23%), Positives = 66/200 (33%), Gaps = 47/200 (23%)
Query: 1268 PETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP- 1326
P TS P ++ VP +P +P +A R + P++ +P A + P P + P
Sbjct: 1085 PRTSPCQSPTISEGPVPSLP----IRPSRAPSR-TPGPPSAQSSPIDAQPATPLPQKDPA 1139
Query: 1327 -PLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385
PL PK PP + AP P PP +G P
Sbjct: 1140 QPLEPKRPPPPRPVAPPT-------------------RPAPPQRPPPPSGARSPAPTRKE 1180
Query: 1386 TSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPK 1445
+P S G + EA PK T D + SP+
Sbjct: 1181 FGGIGAPPSPGVARREMEA-----------------PKSPGTT----RKDNIGRSQPSPQ 1219
Query: 1446 RDPIDPVSAGASAAKAELPP 1465
P AG S A+ +PP
Sbjct: 1220 AGLAGPGPAGYSTARPTIPP 1239
Score = 32.3 bits (72), Expect = 3.5
Identities = 50/240 (20%), Positives = 77/240 (32%), Gaps = 46/240 (19%)
Query: 1170 TTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE--PTPGAAKPETPQAPPLL 1227
T ++AE A +E + + P+ L+ SS +P ++ +P P +
Sbjct: 1036 TLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTI 1095
Query: 1228 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1287
P P +P RT P S + + ++A P P+ P
Sbjct: 1096 SEGPVPSLPIRPSRAPSRTPGPPSAQS---------------SPIDAQPATPLPQKDPA- 1139
Query: 1288 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVP-------PRRKK-- 1338
+P + PP PP APP P P P RK+
Sbjct: 1140 -----------------QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182
Query: 1339 --SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDG 1396
AP + + + + G T + S P AG P ST+ T P G
Sbjct: 1183 GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1242
>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
Length = 1612
Score = 1174 bits (3036), Expect = 0.0
Identities = 628/1343 (46%), Positives = 873/1343 (65%), Gaps = 69/1343 (5%)
Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA
Sbjct: 40 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 98
Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ +
Sbjct: 99 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 158
Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
+K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW
Sbjct: 159 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 217
Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 218 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 277
Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
+DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++
Sbjct: 278 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 337
Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++
Sbjct: 338 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 396
Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
+ D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP +
Sbjct: 397 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 456
Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
V RF E F++MWS+NG S+SK++ G+ ALEGKAK LKDGARS++RTIQ+NFFD KQE
Sbjct: 457 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 513
Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531
AI +LL+G+ ++ADK LL + +L V+ ++LK+M E +++ K+IR
Sbjct: 514 AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 573
Query: 532 IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590
+ +GTWNVNGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVE
Sbjct: 574 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 633
Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
L+AGNIV+ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 634 LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 693
Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710
+DTVKTGMGG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FP
Sbjct: 694 VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 753
Query: 711 MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770
MGR +FSHDYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F
Sbjct: 754 MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813
Query: 771 EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830
EG + F PTYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ +
Sbjct: 814 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 873
Query: 831 TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890
+K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D
Sbjct: 874 SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 933
Query: 891 TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950
TV+V+++S +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL
Sbjct: 934 TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 992
Query: 951 VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010
++G ++ R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E
Sbjct: 993 LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1052
Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057
+ D + + L+ + QP S S LG +S+ P P+ PS++P
Sbjct: 1053 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1111
Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113
+ T + P A + K + + E + P R ++ P R P PPQRPPP
Sbjct: 1112 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1167
Query: 1114 PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNA 1173
P+G A + T ++ + GAP P AR + P + + N
Sbjct: 1168 PSG---------ARSPAPTRKEFGGI-------GAPPSPGVARREMEAPKSPGTTRKDNI 1211
Query: 1174 QEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233
++ + + L G A P S P+ A+ A L P
Sbjct: 1212 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS------AGRLTPESQSK 1265
Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVP---PVPKPR 1290
K T +PL P+ F Q+ ++ PP ++ P V A +P P P
Sbjct: 1266 TSETSKGSTF--LPEPLKPQAAFPPQS---SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1320
Query: 1291 TFQPGKAAERPSHRKPASDEAPP 1313
T R SH P+ + P
Sbjct: 1321 TPPQPPPRSRSSHSLPSEASSQP 1343
Score = 35.0 bits (79), Expect = 0.54
Identities = 47/200 (23%), Positives = 66/200 (33%), Gaps = 47/200 (23%)
Query: 1268 PETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP- 1326
P TS P ++ VP +P +P +A R + P++ +P A + P P + P
Sbjct: 1085 PRTSPCQSPTISEGPVPSLP----IRPSRAPSR-TPGPPSAQSSPIDAQPATPLPQKDPA 1139
Query: 1327 -PLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385
PL PK PP + AP P PP +G P
Sbjct: 1140 QPLEPKRPPPPRPVAPPT-------------------RPAPPQRPPPPSGARSPAPTRKE 1180
Query: 1386 TSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPK 1445
+P S G + EA PK T D + SP+
Sbjct: 1181 FGGIGAPPSPGVARREMEA-----------------PKSPGTT----RKDNIGRSQPSPQ 1219
Query: 1446 RDPIDPVSAGASAAKAELPP 1465
P AG S A+ +PP
Sbjct: 1220 AGLAGPGPAGYSTARPTIPP 1239
Score = 32.3 bits (72), Expect = 3.5
Identities = 50/240 (20%), Positives = 77/240 (32%), Gaps = 46/240 (19%)
Query: 1170 TTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE--PTPGAAKPETPQAPPLL 1227
T ++AE A +E + + P+ L+ SS +P ++ +P P +
Sbjct: 1036 TLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTI 1095
Query: 1228 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1287
P P +P RT P S + + ++A P P+ P
Sbjct: 1096 SEGPVPSLPIRPSRAPSRTPGPPSAQS---------------SPIDAQPATPLPQKDPA- 1139
Query: 1288 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVP-------PRRKK-- 1338
+P + PP PP APP P P P RK+
Sbjct: 1140 -----------------QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182
Query: 1339 --SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDG 1396
AP + + + + G T + S P AG P ST+ T P G
Sbjct: 1183 GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1242
>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
Length = 1295
Score = 1171 bits (3029), Expect = 0.0
Identities = 628/1341 (46%), Positives = 868/1341 (64%), Gaps = 81/1341 (6%)
Query: 1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
MA SKG R+ +L S+++E R +++CL+FE+G VA L+ EKE IKG Y K+ DA
Sbjct: 1 MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59
Query: 61 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
YG LG LRL G T L +LVLVTGC SVG+I ++E++++T+T+F L+ ++ +E+R+ +
Sbjct: 60 YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119
Query: 121 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
+K+L+SG FYF+W G DL++ + + + N FFWNQ LH+ L+ + V+C DW
Sbjct: 120 RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178
Query: 181 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 179 LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238
Query: 241 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
+DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH LK YG+Q++
Sbjct: 239 LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298
Query: 301 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
VNLLGS+ GE +L++AF+ L AS HA D M+NFD+HQ KGGK EKL ++L+PQ++
Sbjct: 299 VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357
Query: 361 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
+ D+ F + R Q GT+R NCLDCLDRTN+VQ+F+ LE+L QL+ LGL+ KP +
Sbjct: 358 FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417
Query: 420 VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
V RF E F++MWS+NG S+SK++ G+ ALEGKAK LKDGARS++RTIQ+NFFD KQE
Sbjct: 418 VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 474
Query: 480 AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531
AI +LL+G+ ++ADK LL + +L V+ ++LK+M E +++ K+IR
Sbjct: 475 AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 534
Query: 532 IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590
+ +GTWNVNGGKQFRS + LTDWLLD+P+L+G + QD S P DIFA+GFEEMVE
Sbjct: 535 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 594
Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
L+AGNIV+ASTTN+K+W +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 595 LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 654
Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710
+DTVKTGMGG GNKGAV IR FH+TS CF+CSH AGQSQVKERNED+ EI +KL FP
Sbjct: 655 VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 714
Query: 711 MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770
MGR +FSHDYVFWCGDFNYRIDL EEV +++Q+W L+ DQL QK++G++F+ F
Sbjct: 715 MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 774
Query: 771 EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830
EG + F PTYKYD+ S YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++ +
Sbjct: 775 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 834
Query: 831 TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890
+K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+ R+ +++EV + QGP D
Sbjct: 835 SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 894
Query: 891 TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950
TV+V+++S +L E N F + L EL+Q S+G ++L+R + +M VTF + SAL+VL
Sbjct: 895 TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 953
Query: 951 VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010
++G ++ R + I K+ DW+K L EE+ ++ S+A S T+++ L E+ D E
Sbjct: 954 LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1013
Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057
+ D + + L+ + QP S S LG +S+ P P+ PS++P
Sbjct: 1014 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1072
Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113
+ T + P A + K + + E + P R ++ P R P PPQRPPP
Sbjct: 1073 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1128
Query: 1114 PTGL---MVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKT 1170
P+G + A S GT + +I G Q P+A P +
Sbjct: 1129 PSGARSPAPTRKEFGAPKSPGTTRKDNI--------GRSQPSPQAGLAGPGPAGYSTARP 1180
Query: 1171 TNAQEAEAAIRCLLEARGGA---SEEALSAVAPRDLEASSEPEP-TPGAAKPETPQAPPL 1226
T A AR A + E+ S + ++ PEP P AA P PP
Sbjct: 1181 TIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPP 1240
Query: 1227 LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPV 1286
R P VP P S P + T P+ PP
Sbjct: 1241 AQRLQEPLVP---------------------------VAAPMPQSGPQPNLETPPQPPPR 1273
Query: 1287 PKPRTFQPGKAAERPSHRKPA 1307
+ P +A+ +P +P+
Sbjct: 1274 SRSSHSLPSEASSQPQQEQPS 1294
Score = 42.0 bits (97), Expect = 0.004
Identities = 52/221 (23%), Positives = 78/221 (35%), Gaps = 27/221 (12%)
Query: 1206 SSEPEPTPGAAKPETPQAP----PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261
SS P +P P + P P+ P R P R P P+ + + P Q+
Sbjct: 1043 SSSPRTSP-CQSPTISEGPVPSLPIRPSRAPSRTPG--PPSAQSSPIDAQPATPLPQKD- 1098
Query: 1262 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP-GKAAERPSHRKPASDEAP-------- 1312
P E PP AP P P R P G + P+ ++ + ++P
Sbjct: 1099 --PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNI 1156
Query: 1313 ------PGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDS 1366
P AG + P P P +PPR + H + S +L +S++
Sbjct: 1157 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA--SAGRLTPESQSKTSET 1214
Query: 1367 PSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL 1407
G + PQ F SS P + + P AAP+
Sbjct: 1215 SKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPM 1255
>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
isoform b [Homo sapiens]
Length = 893
Score = 223 bits (568), Expect = 1e-57
Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%)
Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576
+ +R+ E+ N + R +GTWNVNG + L WL D +
Sbjct: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267
Query: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636
P DI+ +GF+E+ +LS + ++ W +++ + +Y + +LVG+ L I
Sbjct: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326
Query: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696
F R +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A + R
Sbjct: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386
Query: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749
N+DYK+I ++ F + N+ H+ V W GD NYR+ + EV + ++D ++
Sbjct: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446
Query: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809
LL+FDQL +Q++ K F DF+EG I F PTYKYD + +D+S KCR PAW DR+LW
Sbjct: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503
Query: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869
R T + L Y EL+ SDH+PV A+ + V+ V
Sbjct: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538
Query: 870 DVGARERVFQE 880
D +VF++
Sbjct: 539 DERRYRKVFED 549
>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
isoform a [Homo sapiens]
Length = 901
Score = 223 bits (568), Expect = 1e-57
Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%)
Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576
+ +R+ E+ N + R +GTWNVNG + L WL D +
Sbjct: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267
Query: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636
P DI+ +GF+E+ +LS + ++ W +++ + +Y + +LVG+ L I
Sbjct: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326
Query: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696
F R +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A + R
Sbjct: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386
Query: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749
N+DYK+I ++ F + N+ H+ V W GD NYR+ + EV + ++D ++
Sbjct: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446
Query: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809
LL+FDQL +Q++ K F DF+EG I F PTYKYD + +D+S KCR PAW DR+LW
Sbjct: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503
Query: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869
R T + L Y EL+ SDH+PV A+ + V+ V
Sbjct: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538
Query: 870 DVGARERVFQE 880
D +VF++
Sbjct: 539 DERRYRKVFED 549
>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
[Homo sapiens]
Length = 913
Score = 206 bits (525), Expect = 1e-52
Identities = 133/423 (31%), Positives = 212/423 (50%), Gaps = 63/423 (14%)
Query: 494 VADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTA 553
V+DK +L L + + +++ ++T + R GT+NVNG Q LR
Sbjct: 229 VSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNG--QSPKECLRL- 285
Query: 554 ELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQK 613
WL + Q D++ VGF+E+ +LS T ++ W + + +
Sbjct: 286 ----WLSNGIQAP------------DVYCVGFQEL-DLSKEAFFFHDTPKEEEWFKAVSE 328
Query: 614 AISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQ 673
+ +Y + +LVG+ L ++V+ H +I +V +TV TG+ G+ GNKG V IRFQ
Sbjct: 329 GLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQ 388
Query: 674 FHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCF--------PMGRNVFSHDYVFWCG 725
FH+TS C + SHL A + + RN+DYK+I ++ F P+ + +HD + W G
Sbjct: 389 FHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL--TISNHDVILWLG 446
Query: 726 DFNYRI-DLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDV 784
D NYRI +L E+V ++ +D++ L +DQL++Q ++ +F+ F EG + F PTYKYD
Sbjct: 447 DLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDT 506
Query: 785 GSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQY 844
GS +DTS+KCR PAW DR+LW K N+ L Y
Sbjct: 507 GSDDWDTSEKCRAPAWCDRILWKGK-----------NITQ-----------------LSY 538
Query: 845 YGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEK 904
L+ SDH+PV ++ ++ V+ V+ + +E+ LD N+ S +L K
Sbjct: 539 QSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVR---SLDKMENANIPSVSL-SK 594
Query: 905 NEF 907
EF
Sbjct: 595 REF 597
>gi|190014578 suppressor of actin 1 [Homo sapiens]
Length = 587
Score = 190 bits (482), Expect = 1e-47
Identities = 147/492 (29%), Positives = 244/492 (49%), Gaps = 51/492 (10%)
Query: 27 GRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCT 86
G DD L + + +K+V + +G LG + L +G ++L+++T
Sbjct: 26 GADDVLTIDRVSTEVTLAVKKDVPPSAVTR--PIFGILGTIHLVAG----NYLIVITKKI 79
Query: 87 SVGRIPDAEIYKITATDFYPLQE--------EAKEEERLIA-LKKILSSGVFYFSWPNDG 137
VG ++K T D ++ + ++ + +A L +L+ FYFS
Sbjct: 80 KVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFS----- 134
Query: 138 SRFDLTVRTQKQGDDSSEW---------GNSFFWN-QLLHVPLRQHQVSCCDWLLKIICG 187
+ +DLT Q+ + S E+ F WN LL Q +V + L ++ G
Sbjct: 135 TTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVH--RFALPVLHG 192
Query: 188 VVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSS 247
+T+ + + K L+SR SC R G R++ RG++ +GH +NFVETEQ+++ + +S
Sbjct: 193 FITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKAS 252
Query: 248 FVQIRGSVPLFWEQ-PGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGS 306
FVQ RGS+P+FW Q P L+ L + + F RH YG+QV++NL+
Sbjct: 253 FVQTRGSIPVFWSQRPNLKY--KPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQ 310
Query: 307 RGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWE--DF 364
+G E+ L + F ++ +S +G I FDFH+ K + ++L LL ++ E F
Sbjct: 311 KGSEKPLEQTFATMV-SSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYF 369
Query: 365 DVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL----SSKPIV 420
V + G+ V+ Q+G R NC+DCLDRTN +QS +A L QL+ LG+
Sbjct: 370 LVDSAGQVVAN--QEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQ 427
Query: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALE-------GKAKVGKLKDGARSMSRTIQSNFF 473
D F + +K W+ N ++ +K + G+ AL+ + +G + DG SM R ++NF
Sbjct: 428 DEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFS 487
Query: 474 DGVKQEAIKLLL 485
DG +Q++I L L
Sbjct: 488 DGFRQDSIDLFL 499
>gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens]
Length = 1132
Score = 179 bits (455), Expect = 1e-44
Identities = 135/430 (31%), Positives = 211/430 (49%), Gaps = 70/430 (16%)
Query: 108 QEEAKEEERLIA--LKKILSSGVFYFSWPNDGSRFDLTVRTQKQG----DDSSEW---GN 158
+E+ K E RL+ LK + S FY+S +DLT Q+Q D W +
Sbjct: 153 KEKEKLERRLLEELLKMFMDSESFYYSLT-----YDLTNSVQRQSTGERDGRPLWQKVDD 207
Query: 159 SFFWNQLLHVPLRQHQVSCCD-WLLKIICGVVTIRTVYASHKQAK--------------- 202
FFWN+ + L + D W++ +I G V I + ++ ++
Sbjct: 208 RFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQEST 267
Query: 203 ----------ACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIR 252
L+SR S R G R+ RGV+ +G+V+N+VETEQ+I++ + SFVQ R
Sbjct: 268 CVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTR 327
Query: 253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEV 312
GSVP+FW Q G + RL R + F H Y +QV++NL+ G E++
Sbjct: 328 GSVPVFWSQVGYRYNPRP-RLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKI 386
Query: 313 LNRAFKK--LLWASCHAGDTPMINFDFHQFAKGGKLEKLETL------LRPQLKLHW-ED 363
+ A+ K LL+ + H ++FDFH+ +G K E ++TL + +K W ++
Sbjct: 387 IGDAYLKQVLLFNNSH---LTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDE 443
Query: 364 FDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL--SSKPIVD 421
V K Q+G R+NC+DCLDRTN VQ+ IA V+ QLK LG+ +P+
Sbjct: 444 AGVICK--------QEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPV 495
Query: 422 RFVESFKAMWSLNGHSLSKVFTGSRALEG-------KAKVGKLKDGARSMSRTIQSNFFD 474
+ ++ MW+ NG S+S+ + G+ AL+G + G +KDG S +R + F D
Sbjct: 496 KCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKD 555
Query: 475 GVKQEAIKLL 484
+Q I L+
Sbjct: 556 AYRQAVIDLM 565
>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase,
A [Homo sapiens]
Length = 638
Score = 179 bits (453), Expect = 2e-44
Identities = 113/334 (33%), Positives = 167/334 (50%), Gaps = 35/334 (10%)
Query: 531 RIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVE 590
RI + TWNV TA D + L G DDS AD+ A+G +E+
Sbjct: 56 RITVVTWNVG-----------TAMPPDDVTSLLHLGGG----DDSDGADMIAIGLQEVNS 100
Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
+ + +A T++ W E A+ ++L++S ++ GV L +F + YH+PF+RDV
Sbjct: 101 MLNKRLKDALFTDQ--WSELFMDALG-PFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQ 157
Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEIT--QKLC 708
D +TG+GG GNKG V +R CF+ HL A + ++R ++++ I Q+
Sbjct: 158 TDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQ 217
Query: 709 FPMGRNVFSHDYVFWCGDFNYRIDLTYEEVF--YFVKRQDWKKLLEFDQLQLQKSSGKIF 766
P + + HD VFW GD N+RI+ +Y+ F + + +L E DQL + K++ I
Sbjct: 218 GPGAQGILDHDLVFWFGDLNFRIE-SYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPIL 276
Query: 767 KDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSD 826
K F EG +NF PT+K+DVG+ YDTS K R PAWTDR+L W+ K P
Sbjct: 277 KGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRIL-WKVKAP-----------GGG 324
Query: 827 LDVDTKVRHTWSPGALQYYGRAELQASDHRPVLA 860
+ H Y E SDH+PV A
Sbjct: 325 PSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAA 358
>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
sapiens]
Length = 1188
Score = 155 bits (393), Expect = 2e-37
Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%)
Query: 450 GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507
GK + K KDG+ + +K + KL+++ + E++ K + DS
Sbjct: 322 GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 380
Query: 508 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567
++L+ M + SE I I +GTWN+ N ++T W L Q
Sbjct: 381 EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 433
Query: 568 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627
DS D P DI+ +G +E ++K W E L+ ++ T A
Sbjct: 434 RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 480
Query: 628 --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685
L + + + +P H I + D VKTG+ GNKGAVG+ F F+ TS F+ SH
Sbjct: 481 IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 540
Query: 686 LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735
LT+G + RN++Y I + L +G S ++FW GD NYR+DL
Sbjct: 541 LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 598
Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790
E + +K+Q + LL DQL ++ K+F F E I F PTY+++ AY
Sbjct: 599 ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 658
Query: 791 --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848
T K P+W DRVLW K +P + Y +
Sbjct: 659 KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 693
Query: 849 ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906
++ SDH PV A E V V + G +D+ + TL+ K++
Sbjct: 694 DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 744
Query: 907 --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964
F + + +++ ++G+++V F ++ L + D + + + I
Sbjct: 745 TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 804
Query: 965 PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019
K+ D + E I R ++ P+ +P + L +F S+G E
Sbjct: 805 IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 864
Query: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076
D++ DE + P S D + T+ APP ++T + +P Y
Sbjct: 865 DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 915
Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131
VG F P L V P Q P +PP + L + S +
Sbjct: 916 ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 962
Query: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191
GQ I + LP + RT S+P ++ + A
Sbjct: 963 PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1004
Query: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245
+E L P E SS P+P P Q P +PR+ PP P +P +
Sbjct: 1005 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1054
Query: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299
LSP ++ T E P + P P+ R+F +AE
Sbjct: 1055 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1098
Query: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347
+ + P S +AP A + P + PP PP KS PA HLQ
Sbjct: 1099 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1153
>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
sapiens]
Length = 1189
Score = 155 bits (393), Expect = 2e-37
Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%)
Query: 450 GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507
GK + K KDG+ + +K + KL+++ + E++ K + DS
Sbjct: 323 GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 381
Query: 508 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567
++L+ M + SE I I +GTWN+ N ++T W L Q
Sbjct: 382 EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 434
Query: 568 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627
DS D P DI+ +G +E ++K W E L+ ++ T A
Sbjct: 435 RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 481
Query: 628 --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685
L + + + +P H I + D VKTG+ GNKGAVG+ F F+ TS F+ SH
Sbjct: 482 IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 541
Query: 686 LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735
LT+G + RN++Y I + L +G S ++FW GD NYR+DL
Sbjct: 542 LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 599
Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790
E + +K+Q + LL DQL ++ K+F F E I F PTY+++ AY
Sbjct: 600 ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 659
Query: 791 --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848
T K P+W DRVLW K +P + Y +
Sbjct: 660 KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 694
Query: 849 ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906
++ SDH PV A E V V + G +D+ + TL+ K++
Sbjct: 695 DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 745
Query: 907 --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964
F + + +++ ++G+++V F ++ L + D + + + I
Sbjct: 746 TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 805
Query: 965 PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019
K+ D + E I R ++ P+ +P + L +F S+G E
Sbjct: 806 IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 865
Query: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076
D++ DE + P S D + T+ APP ++T + +P Y
Sbjct: 866 DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 916
Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131
VG F P L V P Q P +PP + L + S +
Sbjct: 917 ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 963
Query: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191
GQ I + LP + RT S+P ++ + A
Sbjct: 964 PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1005
Query: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245
+E L P E SS P+P P Q P +PR+ PP P +P +
Sbjct: 1006 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1055
Query: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299
LSP ++ T E P + P P+ R+F +AE
Sbjct: 1056 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1099
Query: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347
+ + P S +AP A + P + PP PP KS PA HLQ
Sbjct: 1100 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1154
>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens]
Length = 1258
Score = 153 bits (387), Expect = 1e-36
Identities = 206/870 (23%), Positives = 326/870 (37%), Gaps = 175/870 (20%)
Query: 512 RILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDS 571
++L+ M + S+ I + +GTWN+ +V +T W S L D
Sbjct: 406 QLLQLMKNKHSKQDEPDMISVFIGTWNMG-------SVPPPKNVTSWFT-SKGLGKTLDE 457
Query: 572 QDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISR----SHRYILLTSA 627
+ P DI+ G +E ++ + W + L+ + +R I + S
Sbjct: 458 VTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQS- 504
Query: 628 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT 687
L + + + V+P H I V+ +VKTG+ GNKGAVG+ F F+ TSF F+ HLT
Sbjct: 505 -LWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLT 563
Query: 688 AGQSQVKERNEDYKEITQKLCFPMGR-NVFS----HDYVFWCGDFNYRIDLTYEEVFYFV 742
+G + RN++Y +I + L + N F ++FW GD NYR+D+ +E+ ++
Sbjct: 564 SGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYI 623
Query: 743 KRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGS-------AAYDTSDKC 795
R++++ LL DQL L++ K+F F E I+F PTY+Y+ GS T +
Sbjct: 624 SRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 683
Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
P+W DR+LW K +P E +++ + Y ++ SDH
Sbjct: 684 NVPSWCDRILW--KSYP------ETHIICN-----------------SYGCTDDIVTSDH 718
Query: 856 RPVLAIVEVEVQEVDVGAR------ERVFQEVSSFQGPLDAT----VVVNLQSPTLEE-K 904
PV EV V + + ++ + E S + + + S LEE K
Sbjct: 719 SPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYK 778
Query: 905 NEFPEDLRT----ELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960
F D ++ ++ S + ++ + D H L+V +DG + G
Sbjct: 779 KSFENDAQSSDNINFLKVQWSSRQLPTLKPILAD-IEYLQDQHLLLTVKSMDGYESYGEC 837
Query: 961 V-----KIRPKTKDWLKGLR---EEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEG 1012
V I + +L L EE R SM PT E +++ S+D + G
Sbjct: 838 VVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAG 897
Query: 1013 DILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDA 1072
+ P VS S P T + P +K PT + A
Sbjct: 898 -----------AKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPA 946
Query: 1073 DLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGT 1132
P R+ P P+ P P G+ A+ +S
Sbjct: 947 -------------------PPRAAPREEPLTPRLKPEGAPEPEGV-----AAPPPKNSFN 982
Query: 1133 HGQYSILQTA--RLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA 1190
+ Y +L+ +LLP P P +A +A + + AI G
Sbjct: 983 NPAYYVLEGVPHQLLPPEPPSPARA-------------PVPSATKNKVAITVPAPQLGHH 1029
Query: 1191 SEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRR--PPPRVPAIKKPTLRRTGK 1248
PR E SS E + G P PPL PP + + P +R G
Sbjct: 1030 RH-------PRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGG 1082
Query: 1249 PLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE--------- 1299
+ GPP P P +PP P P + G+ A
Sbjct: 1083 AEAR-------------GPP-----PPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVL 1124
Query: 1300 RPSHRKPASDEAP--PGAGASVPPPLEAPP 1327
+ + D AP P A +P PLE P
Sbjct: 1125 QMAKTLSEVDYAPAGPARSALLPGPLELQP 1154
Score = 42.0 bits (97), Expect = 0.004
Identities = 43/164 (26%), Positives = 61/164 (37%), Gaps = 13/164 (7%)
Query: 1175 EAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPP-- 1232
+A + R E R G+ + A + + EPE P +P P P PR P
Sbjct: 901 KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAP--PRAAPREEPLT 958
Query: 1233 PRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP---KP 1289
PR+ P P P+ F + G P + PP +P PVP K
Sbjct: 959 PRLKPEGAPEPEGVAAP-PPKNSFNNPAYYVLEGVPHQLL--PPEPPSPARAPVPSATKN 1015
Query: 1290 RTFQPGKAAERPSHRKPASDEAPPG---AGASVPPPLEAPPLVP 1330
+ A + HR P E +G ++PPP PP +P
Sbjct: 1016 KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLP 1059
>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
Length = 644
Score = 139 bits (351), Expect = 2e-32
Identities = 114/386 (29%), Positives = 174/386 (45%), Gaps = 82/386 (21%)
Query: 499 GMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDW 558
G LL S ALL + + +R + + + TWN+ G K+ + L ++
Sbjct: 276 GSLLASGALLGADELARYFPDRN--------VALFVATWNMQGQKELPPS------LDEF 321
Query: 559 LLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRS 618
LL + + D++ +G +E ++++ W +LQ+ +
Sbjct: 322 LLPA----------EADYAQDLYVIGVQE------------GCSDRREWETRLQETLGP- 358
Query: 619 HRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTS 678
Y+LL+SA + + +F+R + F +V TV T + + KGA+GI F F TS
Sbjct: 359 -HYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTS 417
Query: 679 FCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNV--------------FSHDYVFWC 724
F FI SH T+G +V ER DY Q L P RNV D VFW
Sbjct: 418 FLFITSHFTSGDGKVAERLLDYTRTVQALVLP--RNVPDTNPYRSSAADVTTRFDEVFWF 475
Query: 725 GDFNYRID---LTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK 781
GDFN+R+ + + D LL+ DQL + G IFK F E I+F P+YK
Sbjct: 476 GDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYK 535
Query: 782 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA 841
+D+G YD++ K RTP++TDRVL +R +H D V ++ PG
Sbjct: 536 FDIGKDTYDSTSKQRTPSYTDRVL-YRSRHKGD---------------ICPVSYSSCPG- 578
Query: 842 LQYYGRAELQASDHRPVLAIVEVEVQ 867
++ SDHRPV + V+V+
Sbjct: 579 --------IKTSDHRPVYGLFRVKVR 596
Score = 34.7 bits (78), Expect = 0.71
Identities = 50/196 (25%), Positives = 73/196 (37%), Gaps = 25/196 (12%)
Query: 1091 SPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
SP+ + S P P PP R P + + ++S G R G+ Q
Sbjct: 47 SPALACSTPATPSGEDPPARAAPIAPRPPARPRLERALSLDDKGW-----RRRRFRGS-Q 100
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLL-------EARGGASEEALSAVA---P 1200
+ +AR G S Q + A + CL ++RG S E S + P
Sbjct: 101 EDLEARNGTSPSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNP 160
Query: 1201 RDLEASSEPE--PTPGAAKPETPQAPPLLPRRPPPRVPA-IKKPTLRRTGKPLSPEEQFE 1257
ASS P A +P+ P LLP RPPP + I +LR K S ++
Sbjct: 161 LSGVASSSPNLPHRDAAVAGSSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYK 220
Query: 1258 QQT------VHFTIGP 1267
+ H ++GP
Sbjct: 221 LRAQPLLVRAHSSLGP 236
Score = 31.2 bits (69), Expect = 7.8
Identities = 50/223 (22%), Positives = 78/223 (34%), Gaps = 32/223 (14%)
Query: 1284 PPVPKPRTFQPGKAAERPSHRKPASDEAP----PGAGASVP-------PPLEAPPLVPKV 1332
P P+ RT Q P+ R + +AP P S P PP A P+ P+
Sbjct: 15 PQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPPARAAPIAPRP 74
Query: 1333 PPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSP 1392
P R + A L + +G + ++ +G P+ G+V +G S + P
Sbjct: 75 PARPR--LERALSLDDKGWRRRRFRG-SQEDLEARNGTSPSRGSVQSEGPGAPAHSCSPP 131
Query: 1393 DSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDS-GTRSPKRDPIDP 1451
+ P++ +L + S +PL + SP D
Sbjct: 132 CLSTSLQEIPKSRGVLSSERGS---------------PSSGGNPLSGVASSSPNLPHRDA 176
Query: 1452 VSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLA 1494
AG+S L P L + I+ RTA +V LA
Sbjct: 177 AVAGSSPRLPSLLPPRPPPALS--LDIASDSLRTANKVDSDLA 217
>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
sapiens]
Length = 448
Score = 129 bits (323), Expect = 3e-29
Identities = 102/357 (28%), Positives = 165/357 (46%), Gaps = 40/357 (11%)
Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWL-LDSPQLSGATDSQDDS 575
M+ R+ +R+ I + TWNV ++ +L+D L L++ L+
Sbjct: 1 MSSRKLSGPKGRRLSIHVVTWNV-------ASAAPPLDLSDLLQLNNRNLN--------- 44
Query: 576 SPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLY 635
DI+ +G +E+ + +A+ + W L +S +I ++ ++ G+ L
Sbjct: 45 --LDIYVIGLQELNSGIISLLSDAAFNDS--WSSFLMDVLSPLS-FIKVSHVRMQGILLL 99
Query: 636 IFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKE 695
+F + H+P+I+ ++ + TG+ G GNKG V I + + I HL S +
Sbjct: 100 VFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQ 159
Query: 696 RNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTYEEVFYFVKRQDWKKL 750
R E + I + + C GR N+ HD + W GD N+RI D V +K + + L
Sbjct: 160 RLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGL 217
Query: 751 LEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKK 810
E DQL + K + ++F EG + F PTYK+D S YDTS+K R PAWTDR+LW K+
Sbjct: 218 WEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKR 277
Query: 811 HPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ 867
P AG D +S Y SDH+PV ++E++
Sbjct: 278 QP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELK 323
>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
sapiens]
Length = 372
Score = 123 bits (308), Expect = 2e-27
Identities = 81/252 (32%), Positives = 123/252 (48%), Gaps = 18/252 (7%)
Query: 621 YILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680
+I ++ ++ G+ L +F + H+P+I+ ++ + TG+ G GNKG V I + +
Sbjct: 9 FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68
Query: 681 FICSHLTAGQSQVKERNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTY 735
I HL S +R E + I + + C GR N+ HD + W GD N+RI D
Sbjct: 69 IINCHLPPHISNNYQRLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGL 126
Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKC 795
V +K + + L E DQL + K + ++F EG + F PTYK+D S YDTS+K
Sbjct: 127 HFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKK 186
Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
R PAWTDR+LW K+ P AG D +S Y SDH
Sbjct: 187 RKPAWTDRILWRLKRQP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDH 235
Query: 856 RPVLAIVEVEVQ 867
+PV ++E++
Sbjct: 236 KPVSGTFDLELK 247
>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
sapiens]
Length = 372
Score = 123 bits (308), Expect = 2e-27
Identities = 81/252 (32%), Positives = 123/252 (48%), Gaps = 18/252 (7%)
Query: 621 YILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680
+I ++ ++ G+ L +F + H+P+I+ ++ + TG+ G GNKG V I + +
Sbjct: 9 FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68
Query: 681 FICSHLTAGQSQVKERNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTY 735
I HL S +R E + I + + C GR N+ HD + W GD N+RI D
Sbjct: 69 IINCHLPPHISNNYQRLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGL 126
Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKC 795
V +K + + L E DQL + K + ++F EG + F PTYK+D S YDTS+K
Sbjct: 127 HFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKK 186
Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
R PAWTDR+LW K+ P AG D +S Y SDH
Sbjct: 187 RKPAWTDRILWRLKRQP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDH 235
Query: 856 RPVLAIVEVEVQ 867
+PV ++E++
Sbjct: 236 KPVSGTFDLELK 247
>gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo
sapiens]
Length = 907
Score = 105 bits (262), Expect = 3e-22
Identities = 138/531 (25%), Positives = 218/531 (41%), Gaps = 112/531 (21%)
Query: 51 KGQYG--KLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQ 108
KG G + A+G +G +R G ++VL+T + I IYK+ T+ +
Sbjct: 81 KGSSGLFRAVSAFGVVGFVRFLEG----YYIVLITKRRKMADIGGHAIYKVEDTNMIYIP 136
Query: 109 EEA------KEEERLIALKKILSSGVFYFSWPNDGS---RFDLTV-----------RTQK 148
++ E L + + S FYFS+ D S +++LTV TQ
Sbjct: 137 NDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQN 196
Query: 149 QGDD--------------------SSEWGNSFFWN-QLLHV-PLRQHQVSCCDWLLKIIC 186
+ + SE + WN +LL + H+ DWLL II
Sbjct: 197 RQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHR----DWLLYIIH 252
Query: 187 GVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQ-------MI 239
G + + L++R S + GTRF RG N +G V+N VETEQ M
Sbjct: 253 GFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMS 312
Query: 240 YMDDGVSSFVQIRGSVPLFWEQP-GLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQ 298
+ SS+VQ+RGSVPL+W Q + + L + + A H + +++G
Sbjct: 313 FTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQA-DPFAHVAALHFDQMFQRFGSP 371
Query: 299 VVV-NLLGSRGGEEVLNRAFKKLLWASCHAGD-------TPMINFDFHQFAKGGKLEKLE 350
+++ NL+ R + ++L+ A + I +D ++ K L+
Sbjct: 372 IIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLD 431
Query: 351 ------------------------TLLRPQLKLHWEDFDVFTKGENVSP--RFQKGTLRM 384
++LRP K W + G V P R Q G LR
Sbjct: 432 RLNVIAESVVKKTGFFVNRPDSYCSILRPDEK--WNEL-----GGCVIPTGRLQTGILRT 484
Query: 385 NCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD---RFVESFKAMWSLNGHSLSKV 441
NC+DCLDRTNT Q + L QL +LGL KP + V F+ ++ +G +LS
Sbjct: 485 NCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQ 544
Query: 442 FTGSRALEGKAKVGKL-------KDGARSMSRTIQSNFFDGVKQEAIKLLL 485
+ GS+ + K+ KD +++SR + F D +Q++I L L
Sbjct: 545 YGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFL 595
>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
1 [Homo sapiens]
Length = 1250
Score = 68.6 bits (166), Expect = 4e-11
Identities = 102/429 (23%), Positives = 146/429 (34%), Gaps = 57/429 (13%)
Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQY 1136
L + + V + PS L P P PP PP PPPP L +SA A ++ +Y
Sbjct: 609 LSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL-PSQSAPSAGSAAPMFVKY 667
Query: 1137 SI---LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE 1193
S LQ A GA +PP S+ + + N G A +
Sbjct: 668 STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQ 727
Query: 1194 ALSAVAPRDLEASSEPEP-------------TPGAAKPETPQAPPLLPRRPPPRVPAIKK 1240
A L S P P P P P PL P+ PP + I
Sbjct: 728 LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPA 787
Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKP-------RTF- 1292
PT +T P+ + T + + A + +P PPVP P ++F
Sbjct: 788 PTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFC 847
Query: 1293 ---QPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVL 1349
P + PS K + + PP PP +E+ PL P +S PA
Sbjct: 848 AKPPPSPLSPVPSVVKQIASQFPP---PPTPPAMESQPLKPVPANVAPQSPPAVKAKPKW 904
Query: 1350 QSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLST---------SSATSPDSDGTKAM 1400
Q +S + S D P PP + VFP +++ +PD G+
Sbjct: 905 QPSS-----IPVPSPDFPP-PPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK 958
Query: 1401 KPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPI----DPVSAGA 1456
K G + P P N+ + SS + P D + P +
Sbjct: 959 KTSKTSSPGGKKPP-------PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESG 1011
Query: 1457 SAAKAELPP 1465
S +K LPP
Sbjct: 1012 SPSKETLPP 1020
Score = 53.9 bits (128), Expect = 1e-06
Identities = 66/267 (24%), Positives = 97/267 (36%), Gaps = 36/267 (13%)
Query: 1086 EFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLL 1145
+F P SL P P PP P PPPP +AS SG+ G+ + ++
Sbjct: 915 DFPPPPPESSLVFP--PPPPSPVPAPPPPP----PPTASPTPDKSGSPGKKTSKTSS--- 965
Query: 1146 PGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEA 1205
PG + PP P IK+++ E E + + + +S P
Sbjct: 966 PGGKKPPPT-------PQRNSSIKSSSGAEHP-------EPKRPSVDSLVSKFTPPAESG 1011
Query: 1206 SSEPEPTPGAAKPETPQAPPL----LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261
S E P A P P L LP + K P L GK E
Sbjct: 1012 SPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDS 1071
Query: 1262 HFTIGPPETSVEAPPVV--------TAPRVPPV-PKPRTFQPGKAAERPSHRKPASDEAP 1312
F PPET + PP+ T+P+V V P+P+ + + P +P +++
Sbjct: 1072 DFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDST 1131
Query: 1313 PGAGASVPPPLEAPPLVPKVPPRRKKS 1339
A + +VP+VP K S
Sbjct: 1132 RLTQAEISEQPTMATVVPQVPTSPKSS 1158
Score = 42.7 bits (99), Expect = 0.003
Identities = 70/341 (20%), Positives = 104/341 (30%), Gaps = 77/341 (22%)
Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRP 1104
P T APP+ +P + K+ P + + +P P P
Sbjct: 796 PVVTQAAPPTPTPPVPPAKKQPAFP-------------------------ASYIP--PSP 828
Query: 1105 PQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYN 1164
P PP PPPT + + S + + Q A P P P S+P
Sbjct: 829 PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP-- 882
Query: 1165 VKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPET---- 1220
+K + A ++ A++ A + SS P P+P P
Sbjct: 883 LKPVPANVAPQSPPAVK-----------------AKPKWQPSSIPVPSPDFPPPPPESSL 925
Query: 1221 --PQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVV 1278
P PP PPP P PT ++G P G + +P
Sbjct: 926 VFPPPPPSPVPAPPPPPPPTASPTPDKSGSP----------------GKKTSKTSSP--- 966
Query: 1279 TAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKK 1338
+ PP P P+ K++ H +P PP P +PP
Sbjct: 967 -GGKKPP-PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP 1024
Query: 1339 SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFP 1379
P +L + L QG + SG + FP
Sbjct: 1025 PKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFP 1065
Score = 32.7 bits (73), Expect = 2.7
Identities = 72/334 (21%), Positives = 108/334 (32%), Gaps = 72/334 (21%)
Query: 1042 SDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNR 1101
S VP P PP+ SP K SP + S +
Sbjct: 933 SPVPAPPPPPPPTASPTPDKS---------------------------GSPGKKTSKTSS 965
Query: 1102 PRPPQPPQRPPPPTGLMVKKSAS-----------DASISSGTHGQYSILQTARLLPGAPQ 1150
P +PP P P +K S+ D+ +S T S + LP P
Sbjct: 966 PGGKKPP--PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLP-PPA 1022
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210
PPK N+ + A+A + L RG S P S P
Sbjct: 1023 APPKPGKLNLSGVNLPGVLQQGCVSAKAPV---LSGRGKDSVVEF----PSPPSDSDFPP 1075
Query: 1211 PTPGAAKPETP-QAPPLLPRRPPPRVPAI-------KKPTLRRTGKPLSPEEQFEQQTVH 1262
P P P P + P + P+V + K ++++ P P+ +
Sbjct: 1076 PPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQ 1135
Query: 1263 FTIGPPETSVEAPPVVT-APRVPPVPKPR-TFQPGKAAE--RPSHRKPASDEAPPGAGAS 1318
I E P + T P+VP PK + QPG A+ R RK + + S
Sbjct: 1136 AEIS------EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMS 1189
Query: 1319 VPPP------LEAPPLVPKVPPRRKKSAPAAFHL 1346
P + PP P++ ++K+ H+
Sbjct: 1190 RAEPTATMDDMALPPPPPELLSDQQKAGYGGSHI 1223
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 67.4 bits (163), Expect = 1e-10
Identities = 70/258 (27%), Positives = 98/258 (37%), Gaps = 37/258 (14%)
Query: 1091 SPSRSL--SVPNRPRPPQPPQRP----PPPTGLMVKKSASDASISSGTHGQYSILQTARL 1144
SP +S+ SVP R PQPP P PPP+G A +A+ S G L
Sbjct: 1308 SPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEG------------L 1355
Query: 1145 LPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLE 1204
G P P R N++ + + ++ E ++ A+ +E++S+ +
Sbjct: 1356 GLGCPS--PCKRLDEELKRNLETLPSFSSDEEDSV------AKNRDLQESISSA----IS 1403
Query: 1205 ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
A +P P G TP PPL P P P + P L +PE ++ T
Sbjct: 1404 ALDDP-PLAGPKDTSTPDGPPLAPAAAVPGPPPL--PGLPSANSNGTPEPPLLEEKPPPT 1460
Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLE 1324
P T PP P P +P P P A PS P PP PPP
Sbjct: 1461 PPPAPTPQPQPPPPPPPPQPALPSP----PPLVAPTPSSPPPPPLPPPPPPAMPSPPPPP 1516
Query: 1325 APPLVPKVPPRRKKSAPA 1342
P P P + +AP+
Sbjct: 1517 PPAAAPLAAPPEEPAAPS 1534
Score = 43.1 bits (100), Expect = 0.002
Identities = 85/357 (23%), Positives = 117/357 (32%), Gaps = 67/357 (18%)
Query: 1029 PGVSDSELGGDDLSDVPGPTA-LAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEF 1087
PGV G LS V LAPP + D ++L+ G
Sbjct: 578 PGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLA-----GPGGPP 632
Query: 1088 RHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPG 1147
R+ + + + P PP R GL+ + A+DAS G G G
Sbjct: 633 AERTEDEEFLIQHLLQAPSPP-RTSGADGLVGEDGAADASKGLGGSGGAG---------G 682
Query: 1148 APQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLL------------EARGGASEEAL 1195
P P + + Y+++ + T+A E A L RGG + E L
Sbjct: 683 PPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAALELGLGRLKEKKKGPERGGETPEGL 742
Query: 1196 SA------VAPRDLEA---SSEPEPTPGAAKPET-----------PQAPPLLPRRPPPRV 1235
+ ++L A S P P P A + P P +LP PP +
Sbjct: 743 ATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLL 802
Query: 1236 PAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP- 1294
P++ SP + VH P T AP P PP P P +
Sbjct: 803 PSV-------LSHAPSPSPSASKVGVHLL--EPATRDGAPQPPPPPPPPPPPMPLQLEAH 853
Query: 1295 ----GKAAERPSHR-KPASDEAPPGAGASVPPPLEAPPLVP----KVPPRRKKSAPA 1342
G PS R +P PPGA + LE P P PP + PA
Sbjct: 854 LRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPA 910
Score = 42.0 bits (97), Expect = 0.004
Identities = 84/336 (25%), Positives = 107/336 (31%), Gaps = 93/336 (27%)
Query: 1035 ELGGDDLSDV--PGPTALAP------PSKSPALTKKKQH---PTYKDDADLVELKRELEA 1083
E GG DL V P P L P PS SP+ +K H P +D A
Sbjct: 784 EAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGA----------- 832
Query: 1084 VGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAR 1143
P+PP PP PPPP L + +A + S HG + R
Sbjct: 833 ------------------PQPPPPPPPPPPPMPLQL-----EAHLRS--HGLEPAAPSPR 867
Query: 1144 LLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL 1203
L P PP A QE A+ L A G + V P
Sbjct: 868 LRPEESLDPPGA-----------------MQELLGALEPLPPAPGD------TGVGP--- 901
Query: 1204 EASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP--EEQFEQQTV 1261
+SE + GA + +PQ PR P L+ + P EE F
Sbjct: 902 -PNSEGKDPAGAYRSPSPQGTK-APRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAA 959
Query: 1262 --HFTIGPPETSVEAPPVVTAPRVPPVPKP-RTFQPGKAA-------------ERPSHRK 1305
+ GPPE + P PP P + PG+A+ +P
Sbjct: 960 DDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELP 1019
Query: 1306 PASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341
+ P G S P PP P PP S P
Sbjct: 1020 STVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEP 1055
Score = 36.6 bits (83), Expect = 0.19
Identities = 67/270 (24%), Positives = 95/270 (35%), Gaps = 60/270 (22%)
Query: 1071 DADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASI-- 1128
DA ++ L LE+ G S S LS P Q P PT L + + +S
Sbjct: 85 DASVMNLISALESRGPQPGPSASSLLSQFRSPSW-QTAMHTPGPTELFISGALPGSSTFP 143
Query: 1129 SSGTHGQYSI----------LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEA 1178
SS Y + ++ L P PP G+ P++V +K + A +
Sbjct: 144 SSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPA--NGLLSPHDVLHLKPSQAPTVPS 201
Query: 1179 AIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAI 1238
++ A GG + P L + P PG P PP PPPR
Sbjct: 202 SLGFERLAGGGV-------LGPAGLGPAQTPPYRPG------PPDPP-----PPPRHLPT 243
Query: 1239 KKPTLRRTGKPLSPEEQFEQQTVHFT---IGPPETSVEAPPVVTAPRVPPVPKPRTFQPG 1295
+ L + + EQ Q +F+ GPP PP PR V K
Sbjct: 244 QFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPP------PPERALPRQDTVIK------- 290
Query: 1296 KAAERPSHRKPASDEAPPGAGASVPPPLEA 1325
+++PAS + PP PPP A
Sbjct: 291 ------HYQRPASAQPPP-----PPPPAHA 309
Score = 35.4 bits (80), Expect = 0.42
Identities = 30/112 (26%), Positives = 46/112 (41%), Gaps = 11/112 (9%)
Query: 1231 PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRV-PPVPKP 1289
PPP+ PA KP +PE+ ++ T PET++ PP P + PV K
Sbjct: 1692 PPPKAPAPPP-------KPETPEKTTSEKPPEQT---PETAMPEPPAPEKPSLLRPVEKE 1741
Query: 1290 RTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341
+ + ERP + A+ S+ A +PK P + K+ P
Sbjct: 1742 KEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEP 1793
Score = 31.2 bits (69), Expect = 7.8
Identities = 28/120 (23%), Positives = 43/120 (35%), Gaps = 2/120 (1%)
Query: 1099 PNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTG 1158
P P PP PP+ P L+ SA+ A+ + Y+ A P + P+ T
Sbjct: 229 PGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTV 288
Query: 1159 ISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKP 1218
I + A++ L G S ++ A EP+PGA +P
Sbjct: 289 IKHYQRPASAQPPPPPPPAHALQHYLSC--GGSYPSMGHRANLACSPLGGGEPSPGAGEP 346
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 67.0 bits (162), Expect = 1e-10
Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)
Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
P PT P+ K PA T K PT K+ A K E +P P
Sbjct: 270 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 327
Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
P+ P P + P PT + + T + + P P++P T
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 379
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
P K+ T + A + E ++ A + + EP PT P P
Sbjct: 380 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436
Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
TP+ P P P+ P P P PT + P +P+E P+ P
Sbjct: 437 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 496
Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
AP P P P T + A P P + E AP A+ P P E P PK P
Sbjct: 497 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 555
Query: 1335 RRKKSAPA 1342
PA
Sbjct: 556 PTTPKEPA 563
Score = 63.2 bits (152), Expect = 2e-09
Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)
Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
P PT + AP + K PA T K PT + K + + +P+ +
Sbjct: 232 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 291
Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
S P P+ P P P++P P T + + + + T + T P P++P
Sbjct: 292 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 348
Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
A T KP + E A E +E + EP PT
Sbjct: 349 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 407
Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
+ P TP+ P P P+ P P P PT + P +P+E T
Sbjct: 408 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467
Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
P+ P TAP P P T + P K A P P + E P
Sbjct: 468 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 527
Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
P P A P PK P PA
Sbjct: 528 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 555
Score = 63.2 bits (152), Expect = 2e-09
Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)
Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
P PT P +P TKK T K+ A + + +P + + + P +P
Sbjct: 450 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 507
Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
P P P P PT ++ A + + + T + + P P++P
Sbjct: 508 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 567
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
+ P K T +E + E A + +P PT P
Sbjct: 568 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623
Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ +
Sbjct: 624 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 683
Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
P P TAP P P P T P P + E PP + S P + P
Sbjct: 684 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 734
Query: 1329 VPKVP 1333
+ K P
Sbjct: 735 IHKSP 739
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)
Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
+L+ P P P P + P PT +K + + + T T + P P+
Sbjct: 209 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 260
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
+P T P K+ T +E + + + + + P++ +
Sbjct: 261 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 320
Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
+ EPTP K P T + P P+ P P P PT + P +P+E T
Sbjct: 321 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 380
Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
T P T+ E P T AP P P P T + A P P +
Sbjct: 381 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 439
Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
+ P + P E P PK P KK AP
Sbjct: 440 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 468
Score = 56.2 bits (134), Expect = 2e-07
Identities = 67/264 (25%), Positives = 98/264 (37%), Gaps = 33/264 (12%)
Query: 1091 SPSRSLSVPNRPRPPQPPQR-PPPPTGLMVKKSAS-DASISSGTHGQYSILQTARLLPGA 1148
SP + + P PRP PP T L V K + + ++ T+ Q S G
Sbjct: 115 SPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS-------TDGK 167
Query: 1149 PQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA--SEEALSAVAPRDLEAS 1206
+ T + + K + T+ A+ + +G A + + + P++ ++
Sbjct: 168 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST 227
Query: 1207 SEPEPTPGAAK--PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
+ EPTP K P TP+ P + P P PT + P +P+E
Sbjct: 228 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP--------- 278
Query: 1265 IGPPETSVEAPPVVT--APRVPPVPKPRTFQPGK-AAERPSHRKPASDEAPPGAGASVPP 1321
P T+ E P T AP P P P T P K A P P + + P P
Sbjct: 279 --APTTTKEPAPTTTKSAPTTPKEPAPTT--PKKPAPTTPKEPAPTTPKEPTPTTPKEPA 334
Query: 1322 PL--EAPPLVPK--VPPRRKKSAP 1341
P E P PK P KK AP
Sbjct: 335 PTTKEPAPTTPKEPAPTAPKKPAP 358
Score = 43.5 bits (101), Expect = 0.002
Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 43/260 (16%)
Query: 1105 PQPPQRPPPPTGLM---VKKSASDASISSGTHGQYSI---LQTARLLPGAPQQPPKARTG 1158
P+PP +GL K + D S + H + S + TA+ + P PP + T
Sbjct: 80 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNKVSTSPKITTAKPINPRPSLPPNSDTS 137
Query: 1159 ------ISKPYNV--KQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSE-- 1208
++K V K+ TTN Q + A+ S E SA +DL +S+
Sbjct: 138 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA---KDLAPTSKVL 194
Query: 1209 PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
+PTP K ET P L P+ P P P K T K +P TI
Sbjct: 195 AKPTP---KAETTTKGPALTTPKEPTPTTP---KEPASTTPKEPTPT----------TIK 238
Query: 1267 PPETSVEAPPVVTAPRVPPVPK----PRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322
T+ + P T P PK T +P + + AP ++ P
Sbjct: 239 SAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 298
Query: 1323 LEAPPLVPKVPPRRKKSAPA 1342
E P PK P PA
Sbjct: 299 KEPAPTTPKKPAPTTPKEPA 318
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 67.0 bits (162), Expect = 1e-10
Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)
Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
P PT P+ K PA T K PT K+ A K E +P P
Sbjct: 311 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 368
Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
P+ P P + P PT + + T + + P P++P T
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 420
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
P K+ T + A + E ++ A + + EP PT P P
Sbjct: 421 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477
Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
TP+ P P P+ P P P PT + P +P+E P+ P
Sbjct: 478 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 537
Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
AP P P P T + A P P + E AP A+ P P E P PK P
Sbjct: 538 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 596
Query: 1335 RRKKSAPA 1342
PA
Sbjct: 597 PTTPKEPA 604
Score = 63.2 bits (152), Expect = 2e-09
Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)
Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
P PT + AP + K PA T K PT + K + + +P+ +
Sbjct: 273 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 332
Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
S P P+ P P P++P P T + + + + T + T P P++P
Sbjct: 333 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 389
Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
A T KP + E A E +E + EP PT
Sbjct: 390 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 448
Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
+ P TP+ P P P+ P P P PT + P +P+E T
Sbjct: 449 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508
Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
P+ P TAP P P T + P K A P P + E P
Sbjct: 509 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 568
Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
P P A P PK P PA
Sbjct: 569 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 596
Score = 63.2 bits (152), Expect = 2e-09
Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)
Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
P PT P +P TKK T K+ A + + +P + + + P +P
Sbjct: 491 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 548
Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
P P P P PT ++ A + + + T + + P P++P
Sbjct: 549 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 608
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
+ P K T +E + E A + +P PT P
Sbjct: 609 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664
Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ +
Sbjct: 665 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 724
Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
P P TAP P P P T P P + E PP + S P + P
Sbjct: 725 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 775
Query: 1329 VPKVP 1333
+ K P
Sbjct: 776 IHKSP 780
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)
Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
+L+ P P P P + P PT +K + + + T T + P P+
Sbjct: 250 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 301
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
+P T P K+ T +E + + + + + P++ +
Sbjct: 302 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 361
Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
+ EPTP K P T + P P+ P P P PT + P +P+E T
Sbjct: 362 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 421
Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
T P T+ E P T AP P P P T + A P P +
Sbjct: 422 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 480
Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
+ P + P E P PK P KK AP
Sbjct: 481 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 509
Score = 56.2 bits (134), Expect = 2e-07
Identities = 67/264 (25%), Positives = 98/264 (37%), Gaps = 33/264 (12%)
Query: 1091 SPSRSLSVPNRPRPPQPPQR-PPPPTGLMVKKSAS-DASISSGTHGQYSILQTARLLPGA 1148
SP + + P PRP PP T L V K + + ++ T+ Q S G
Sbjct: 156 SPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS-------TDGK 208
Query: 1149 PQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA--SEEALSAVAPRDLEAS 1206
+ T + + K + T+ A+ + +G A + + + P++ ++
Sbjct: 209 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST 268
Query: 1207 SEPEPTPGAAK--PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
+ EPTP K P TP+ P + P P PT + P +P+E
Sbjct: 269 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP--------- 319
Query: 1265 IGPPETSVEAPPVVT--APRVPPVPKPRTFQPGK-AAERPSHRKPASDEAPPGAGASVPP 1321
P T+ E P T AP P P P T P K A P P + + P P
Sbjct: 320 --APTTTKEPAPTTTKSAPTTPKEPAPTT--PKKPAPTTPKEPAPTTPKEPTPTTPKEPA 375
Query: 1322 PL--EAPPLVPK--VPPRRKKSAP 1341
P E P PK P KK AP
Sbjct: 376 PTTKEPAPTTPKEPAPTAPKKPAP 399
Score = 43.5 bits (101), Expect = 0.002
Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 43/260 (16%)
Query: 1105 PQPPQRPPPPTGLM---VKKSASDASISSGTHGQYSI---LQTARLLPGAPQQPPKARTG 1158
P+PP +GL K + D S + H + S + TA+ + P PP + T
Sbjct: 121 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNKVSTSPKITTAKPINPRPSLPPNSDTS 178
Query: 1159 ------ISKPYNV--KQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSE-- 1208
++K V K+ TTN Q + A+ S E SA +DL +S+
Sbjct: 179 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA---KDLAPTSKVL 235
Query: 1209 PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
+PTP K ET P L P+ P P P K T K +P TI
Sbjct: 236 AKPTP---KAETTTKGPALTTPKEPTPTTP---KEPASTTPKEPTPT----------TIK 279
Query: 1267 PPETSVEAPPVVTAPRVPPVPK----PRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322
T+ + P T P PK T +P + + AP ++ P
Sbjct: 280 SAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 339
Query: 1323 LEAPPLVPKVPPRRKKSAPA 1342
E P PK P PA
Sbjct: 340 KEPAPTTPKKPAPTTPKEPA 359
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 67.0 bits (162), Expect = 1e-10
Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)
Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
P PT P+ K PA T K PT K+ A K E +P P
Sbjct: 363 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 420
Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
P+ P P + P PT + + T + + P P++P T
Sbjct: 421 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 472
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
P K+ T + A + E ++ A + + EP PT P P
Sbjct: 473 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529
Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
TP+ P P P+ P P P PT + P +P+E P+ P
Sbjct: 530 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 589
Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
AP P P P T + A P P + E AP A+ P P E P PK P
Sbjct: 590 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 648
Query: 1335 RRKKSAPA 1342
PA
Sbjct: 649 PTTPKEPA 656
Score = 63.2 bits (152), Expect = 2e-09
Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)
Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
P PT + AP + K PA T K PT + K + + +P+ +
Sbjct: 325 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 384
Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
S P P+ P P P++P P T + + + + T + T P P++P
Sbjct: 385 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 441
Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
A T KP + E A E +E + EP PT
Sbjct: 442 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 500
Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
+ P TP+ P P P+ P P P PT + P +P+E T
Sbjct: 501 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560
Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
P+ P TAP P P T + P K A P P + E P
Sbjct: 561 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 620
Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
P P A P PK P PA
Sbjct: 621 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 648
Score = 63.2 bits (152), Expect = 2e-09
Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)
Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
P PT P +P TKK T K+ A + + +P + + + P +P
Sbjct: 543 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 600
Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
P P P P PT ++ A + + + T + + P P++P
Sbjct: 601 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 660
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
+ P K T +E + E A + +P PT P
Sbjct: 661 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716
Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ +
Sbjct: 717 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 776
Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
P P TAP P P P T P P + E PP + S P + P
Sbjct: 777 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 827
Query: 1329 VPKVP 1333
+ K P
Sbjct: 828 IHKSP 832
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)
Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
+L+ P P P P + P PT +K + + + T T + P P+
Sbjct: 302 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 353
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
+P T P K+ T +E + + + + + P++ +
Sbjct: 354 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 413
Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
+ EPTP K P T + P P+ P P P PT + P +P+E T
Sbjct: 414 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 473
Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
T P T+ E P T AP P P P T + A P P +
Sbjct: 474 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 532
Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
+ P + P E P PK P KK AP
Sbjct: 533 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 561
Score = 45.1 bits (105), Expect = 5e-04
Identities = 72/286 (25%), Positives = 104/286 (36%), Gaps = 47/286 (16%)
Query: 1079 RELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM---VKKSASDASISSGTHGQ 1135
REL+ + + +R+ P P+PP +GL K + D S + H +
Sbjct: 151 RELQKKLKVKDNKKNRTKKKPT----PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNK 204
Query: 1136 YSI---LQTARLLPGAPQQPPKARTG------ISKPYNV--KQIKTTNAQEAEAAIRCLL 1184
S + TA+ + P PP + T ++K V K+ TTN Q +
Sbjct: 205 VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 264
Query: 1185 EARGGASEEALSAVAPRDLEASSE--PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKK 1240
A+ S E SA +DL +S+ +PTP K ET P L P+ P P P K
Sbjct: 265 SAKETQSIEKTSA---KDLAPTSKVLAKPTP---KAETTTKGPALTTPKEPTPTTP---K 315
Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPK----PRTFQPGK 1296
T K +P TI T+ + P T P PK T +P
Sbjct: 316 EPASTTPKEPTPT----------TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 365
Query: 1297 AAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA 1342
+ + AP ++ P E P PK P PA
Sbjct: 366 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411
Score = 39.3 bits (90), Expect = 0.029
Identities = 54/261 (20%), Positives = 90/261 (34%), Gaps = 27/261 (10%)
Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASIS-----SGTHGQYSILQTARLLPGAPQQPPKART 1157
R P+PP + + ++ + S+S S + S T R + + A
Sbjct: 94 RSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSA--ANR 151
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217
+ K VK K ++ +++ G + V D +S + +
Sbjct: 152 ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPD---TSTTQHNKVSTS 208
Query: 1218 PETPQAPPLLPRRP-PPRVPAIKKPTLR-------------RTGKPLSPEEQFEQQTVHF 1263
P+ A P+ PR PP K+ +L T K S + + + +
Sbjct: 209 PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 268
Query: 1264 TIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP- 1322
T +TS + + P PK T G A P P + + P P P
Sbjct: 269 TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT 328
Query: 1323 -LEAPPLVPKVP-PRRKKSAP 1341
+++ P PK P P KSAP
Sbjct: 329 TIKSAPTTPKEPAPTTTKSAP 349
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 67.0 bits (162), Expect = 1e-10
Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)
Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
P PT P+ K PA T K PT K+ A K E +P P
Sbjct: 404 PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 461
Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
P+ P P + P PT + + T + + P P++P T
Sbjct: 462 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 513
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
P K+ T + A + E ++ A + + EP PT P P
Sbjct: 514 PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570
Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
TP+ P P P+ P P P PT + P +P+E P+ P
Sbjct: 571 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 630
Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
AP P P P T + A P P + E AP A+ P P E P PK P
Sbjct: 631 KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 689
Query: 1335 RRKKSAPA 1342
PA
Sbjct: 690 PTTPKEPA 697
Score = 63.2 bits (152), Expect = 2e-09
Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)
Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
P PT + AP + K PA T K PT + K + + +P+ +
Sbjct: 366 PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 425
Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
S P P+ P P P++P P T + + + + T + T P P++P
Sbjct: 426 KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 482
Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
A T KP + E A E +E + EP PT
Sbjct: 483 -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 541
Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
+ P TP+ P P P+ P P P PT + P +P+E T
Sbjct: 542 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601
Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
P+ P TAP P P T + P K A P P + E P
Sbjct: 602 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 661
Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
P P A P PK P PA
Sbjct: 662 EEPAPTTPKAAAPNTPKEPAPTTPKEPA 689
Score = 63.2 bits (152), Expect = 2e-09
Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)
Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
P PT P +P TKK T K+ A + + +P + + + P +P
Sbjct: 584 PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 641
Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
P P P P PT ++ A + + + T + + P P++P
Sbjct: 642 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 701
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
+ P K T +E + E A + +P PT P
Sbjct: 702 KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757
Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
P TP+ P P P+ P P P PT + P +P++ ++ T GP T+ +
Sbjct: 758 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 817
Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
P P TAP P P P T P P + E PP + S P + P
Sbjct: 818 PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 868
Query: 1329 VPKVP 1333
+ K P
Sbjct: 869 IHKSP 873
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)
Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
+L+ P P P P + P PT +K + + + T T + P P+
Sbjct: 343 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 394
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
+P T P K+ T +E + + + + + P++ +
Sbjct: 395 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 454
Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
+ EPTP K P T + P P+ P P P PT + P +P+E T
Sbjct: 455 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 514
Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
T P T+ E P T AP P P P T + A P P +
Sbjct: 515 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 573
Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
+ P + P E P PK P KK AP
Sbjct: 574 KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 602
Score = 45.1 bits (105), Expect = 5e-04
Identities = 72/286 (25%), Positives = 104/286 (36%), Gaps = 47/286 (16%)
Query: 1079 RELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM---VKKSASDASISSGTHGQ 1135
REL+ + + +R+ P P+PP +GL K + D S + H +
Sbjct: 192 RELQKKLKVKDNKKNRTKKKPT----PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNK 245
Query: 1136 YSI---LQTARLLPGAPQQPPKARTG------ISKPYNV--KQIKTTNAQEAEAAIRCLL 1184
S + TA+ + P PP + T ++K V K+ TTN Q +
Sbjct: 246 VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 305
Query: 1185 EARGGASEEALSAVAPRDLEASSE--PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKK 1240
A+ S E SA +DL +S+ +PTP K ET P L P+ P P P K
Sbjct: 306 SAKETQSIEKTSA---KDLAPTSKVLAKPTP---KAETTTKGPALTTPKEPTPTTP---K 356
Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPK----PRTFQPGK 1296
T K +P TI T+ + P T P PK T +P
Sbjct: 357 EPASTTPKEPTPT----------TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 406
Query: 1297 AAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA 1342
+ + AP ++ P E P PK P PA
Sbjct: 407 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452
Score = 39.3 bits (90), Expect = 0.029
Identities = 54/261 (20%), Positives = 90/261 (34%), Gaps = 27/261 (10%)
Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASIS-----SGTHGQYSILQTARLLPGAPQQPPKART 1157
R P+PP + + ++ + S+S S + S T R + + A
Sbjct: 135 RSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSA--ANR 192
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217
+ K VK K ++ +++ G + V D +S + +
Sbjct: 193 ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPD---TSTTQHNKVSTS 249
Query: 1218 PETPQAPPLLPRRP-PPRVPAIKKPTLR-------------RTGKPLSPEEQFEQQTVHF 1263
P+ A P+ PR PP K+ +L T K S + + + +
Sbjct: 250 PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 309
Query: 1264 TIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP- 1322
T +TS + + P PK T G A P P + + P P P
Sbjct: 310 TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT 369
Query: 1323 -LEAPPLVPKVP-PRRKKSAP 1341
+++ P PK P P KSAP
Sbjct: 370 TIKSAPTTPKEPAPTTTKSAP 390
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 65.1 bits (157), Expect = 5e-10
Identities = 81/322 (25%), Positives = 104/322 (32%), Gaps = 33/322 (10%)
Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP----KART 1157
P PP PQ PPP G + G Q PG PQ PP K+R+
Sbjct: 51 PSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS 110
Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217
S P + +G + P + P G K
Sbjct: 111 PRSPPG---------------------KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 149
Query: 1218 PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
P+ P PP P+ PPP+ + + GKP P Q Q P + P
Sbjct: 150 PQGP-PPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 208
Query: 1278 VTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335
P+ PP P KP+ P G + + P + PP G + P PP P+ PP
Sbjct: 209 GNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 268
Query: 1336 RKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGH---PPAAGTVFPQGDFLSTSSATSP 1392
+ + P G SS SP G PP G PQG P
Sbjct: 269 QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 328
Query: 1393 DSDGTKAMKPEAAPLLGDYQDP 1414
G KP+ P G Q P
Sbjct: 329 PPQG--GNKPQGPPPPGKPQGP 348
Score = 61.2 bits (147), Expect = 7e-09
Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 17/324 (5%)
Query: 1100 NRPRPPQPPQRP--PPPTGLMVKKSASDASISSGTHGQ-YSILQTARLLPGAPQQPP--- 1153
N+P+ P PP +P PPP G + S G Q + Q PG PQ PP
Sbjct: 87 NKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 146
Query: 1154 -KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT 1212
G P + ++ ++ + +G + P + P
Sbjct: 147 GNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 206
Query: 1213 PGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSV 1272
G KP+ P PP P+ PPP+ + GKP P Q Q P +
Sbjct: 207 QGGNKPQGP-PPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 265
Query: 1273 EAPPVVTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVP 1330
P P+ PP P KP+ P G + R S P + PP G + P PP P
Sbjct: 266 PPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 325
Query: 1331 KVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSAT 1390
+ PP + + P G S+ SP G P PQ + +
Sbjct: 326 QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGP----PQQE--GNNPQG 379
Query: 1391 SPDSDGTKAMKPEAAPLLGDYQDP 1414
P G +P+A P G Q P
Sbjct: 380 PPPPAGGNPQQPQAPP-AGQPQGP 402
Score = 60.1 bits (144), Expect = 2e-08
Identities = 65/261 (24%), Positives = 92/261 (35%), Gaps = 12/261 (4%)
Query: 1092 PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSIL-QTARLLPGAPQ 1150
P + + P P PP PQ PPP + S S G Q Q PG PQ
Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 202
Query: 1151 QPP----KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
PP G P + ++++A + +G + P
Sbjct: 203 GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGK 262
Query: 1207 SEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
+ P G KP+ P PP P+ PPP+ + + + GKP P Q Q
Sbjct: 263 PQGPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 321
Query: 1267 PPETSVEAPPVVTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGAS----VP 1320
P + P P+ PP P KP+ P G + R + P + PP + P
Sbjct: 322 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP 381
Query: 1321 PPLEAPPLVPKVPPRRKKSAP 1341
PP P P+ PP + P
Sbjct: 382 PPAGGNPQQPQAPPAGQPQGP 402
Score = 56.2 bits (134), Expect = 2e-07
Identities = 67/286 (23%), Positives = 90/286 (31%), Gaps = 43/286 (15%)
Query: 1184 LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTL 1243
L + +E+ +P + + + P G KP+ P +PP P+ PPP+ +
Sbjct: 13 LSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPP 72
Query: 1244 RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP-KPRTFQPGKAAERPS 1302
GKP P PP+ P+ PP P KP+ P R
Sbjct: 73 PPPGKPQGP--------------PPQGG-------NKPQGPPPPGKPQGPPPQGDKSRSP 111
Query: 1303 HRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYN 1362
P + PP G + P PP P+ PP + + P
Sbjct: 112 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171
Query: 1363 SSDSPSGH---PPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLL 1419
SS SP G PP G PQG P G KP+ P G Q P
Sbjct: 172 SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGP----- 224
Query: 1420 HHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPP 1465
D RSP P P G + + PP
Sbjct: 225 -----------PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259
Score = 47.4 bits (111), Expect = 1e-04
Identities = 41/152 (26%), Positives = 55/152 (36%), Gaps = 7/152 (4%)
Query: 1092 PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSIL-QTARLLPGAPQ 1150
P + + P P PP PQ PPP G + S S G Q Q PG PQ
Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210
PP G +KP + + +R S P+ + +
Sbjct: 327 GPPPQ--GGNKPQGPPPPGKPQGPPPQGGSK----SRSARSPPGKPQGPPQQEGNNPQGP 380
Query: 1211 PTPGAAKPETPQAPPLLPRRPPPRVPAIKKPT 1242
P P P+ PQAPP + PPR P +P+
Sbjct: 381 PPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPS 412
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 64.3 bits (155), Expect = 8e-10
Identities = 96/367 (26%), Positives = 131/367 (35%), Gaps = 62/367 (16%)
Query: 1045 PGPTALA-PPSKSP--ALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSV--- 1098
P P+A PP++ P +++ +H T + R + G R SRSLS
Sbjct: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSP----AARRRPSAGGGLQRPASRSLSSSAT 238
Query: 1099 ----PNRPRP-----PQPPQRP--PPPTGLM------VKKSASDASISSGTHGQYSILQT 1141
P R P P+ P P P P GL V DA+ + G +
Sbjct: 239 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 298
Query: 1142 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR 1201
+ P +P PP +T S P TT+ G + +A + P
Sbjct: 299 SPSAPPSPSAPPSLQTLPSPPATPPSQATTSL--------------GSPTLQATHSFLP- 343
Query: 1202 DLEASSEPEPTPGAAKPETPQAPPLL---PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQ 1258
P +P A P PQAPP L P + PP PA + T P +P
Sbjct: 344 ------SPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395
Query: 1259 QTVHFTIGPPETSVEAP-PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGA 1317
PP V+AP +P V P P + P A P P+ +PP + +
Sbjct: 396 LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 455
Query: 1318 SVPPPL-----EAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
+ PPP APPL PP + A A LQ L S G + SPS P
Sbjct: 456 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG---QAPFSPSASLP 512
Query: 1373 AAGTVFP 1379
+ P
Sbjct: 513 MSPLATP 519
Score = 58.2 bits (139), Expect = 6e-08
Identities = 80/338 (23%), Positives = 111/338 (32%), Gaps = 26/338 (7%)
Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVEL-KRELEAVGEFRHRSPSRSLSVPNRPR 1103
P P+A PS P+L P L L+A F P L+ P
Sbjct: 298 PSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357
Query: 1104 PPQ----PPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
PP P Q PP P + S + +LQ P +P
Sbjct: 358 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
S P + + A + AA + AS P TP P
Sbjct: 418 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SPSATPPPQAPP 464
Query: 1220 TPQAPPLLPRRPPPRVP-AIKKPTLRRTGKPLS--PEEQFEQQTVHFTIGPPETSV-EAP 1275
APPL +PPP+ P A+ P L+ P + P + + + P T +AP
Sbjct: 465 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 524
Query: 1276 PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335
PV+ AP + P P +A RP P + + P ++ P PP P P
Sbjct: 525 PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPS 581
Query: 1336 RKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
S P A H S + L+G + PP
Sbjct: 582 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 619
Score = 50.8 bits (120), Expect = 1e-05
Identities = 101/424 (23%), Positives = 137/424 (32%), Gaps = 71/424 (16%)
Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASIS-------SGTHGQYSILQTA-RLLPGAPQQPP 1153
PRPP P+ PPP T ++ + ++ +G G +I ++A R P +PP
Sbjct: 27 PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86
Query: 1154 KARTG-------------ISKPYNVKQIKTTNAQEAEAAIRCLLE---ARGGASE----E 1193
+ G +S P T + +R E ARG A+E
Sbjct: 87 ASGRGERAPPAKNTSPGPVSSPGRASG-TTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
Query: 1194 ALSAVAPRDLEASSEPEPTPGAAKPE--------TPQAPPLLPRRPPPRVP--------- 1236
ALSA A RD + P+P A+ P+ P RPP P
Sbjct: 146 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205
Query: 1237 ---AIKKPTLRRT----GKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKP 1289
P RR G P + + P + A AP P PKP
Sbjct: 206 HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP 265
Query: 1290 RTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP----PLVPKVPP--RRKKSAPAA 1343
+ G A RP P +A P G PL P P P PP + S PA
Sbjct: 266 K----GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT 321
Query: 1344 FHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPE 1403
Q S T++ SP P A P + + P
Sbjct: 322 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381
Query: 1404 AAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAEL 1463
A P Q P +H LL + S P+ + P P+ P + S A L
Sbjct: 382 ATP---SPQAPNALAVH---LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 435
Query: 1464 --PP 1465
PP
Sbjct: 436 AAPP 439
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 62.0 bits (149), Expect = 4e-09
Identities = 73/278 (26%), Positives = 111/278 (39%), Gaps = 40/278 (14%)
Query: 1090 RSPSRSLSVPNRPRPPQPPQRP--PPPTGLMVKKSASDASISSGTHGQYSILQTARL--L 1145
++ S L+ P+ PP P P PP+ L + +SI++ L + L L
Sbjct: 547 QTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGL 606
Query: 1146 PGAPQQP-----PKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200
P P P P+A ++ P ++ + A + L S +A +A+A
Sbjct: 607 PSPPLSPLATPPPQAPPXLALP----PLQAPPSPPASPPLSPLATP----SPQAPNALAV 658
Query: 1201 RDLEASSEPEPTPGAAKPETPQA-PPLLPRRPPPRV--PAIKKPTLRRTGKPLSPEEQFE 1257
L+A P P+P P +P A PP+ P PP P++ P L+ P +
Sbjct: 659 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 718
Query: 1258 QQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKP-----ASDEAP 1312
T PP +APP + AP + P P P + P R P + P
Sbjct: 719 SAT------PPP---QAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVP 769
Query: 1313 PGAGASVP------PPLEAPPLVPKVPPRRKKSAPAAF 1344
P AS+P PP +APP + P + S PA+F
Sbjct: 770 PSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASF 807
Score = 60.5 bits (145), Expect = 1e-08
Identities = 89/374 (23%), Positives = 129/374 (34%), Gaps = 81/374 (21%)
Query: 1081 LEAVGEFRHRSPSR---SLSVPNRPR---PPQPPQRPP------PPTGLMVKKSASDASI 1128
L+A F SP + SL+ P+RP P PP + P PP + + S S
Sbjct: 423 LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482
Query: 1129 SSGTHGQYSILQTARLLPGAP-----QQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCL 1183
H ++ A P AP P + ++ ++ P ++T A +
Sbjct: 483 PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPP----SLQTPPASLTTPPL--- 535
Query: 1184 LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETP-----QAPPLLPRRPPPRV--- 1235
E L ++AP L+ +S P TP P P QAPP PPP
Sbjct: 536 ---------ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSS 586
Query: 1236 ---------PAIKKPTLR-RTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPP 1285
PA+ P L+ PLSP Q PP + +PP +P + P
Sbjct: 587 IATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPP--ASPPLSP 644
Query: 1286 VPKPRTFQPGKAA-----------ERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPP 1334
+ P P A P + P S A P S PP +APP + P
Sbjct: 645 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 704
Query: 1335 RRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDS 1394
+ S PA+ ++ +++ P PP A + S SP
Sbjct: 705 QVPPSPPAS-------------PPMSPSATPPPQAPPPLAAPPLQ----VPPSPPASPPM 747
Query: 1395 DGTKAMKPEAAPLL 1408
+ P PLL
Sbjct: 748 SPSATPPPRVPPLL 761
Score = 55.5 bits (132), Expect = 4e-07
Identities = 69/278 (24%), Positives = 97/278 (34%), Gaps = 49/278 (17%)
Query: 1104 PPQPPQRPPP--PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPK-ARTGIS 1160
PP P PPP P+ + + +++S + L PQ PP A +
Sbjct: 572 PPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQ 631
Query: 1161 KPYN------VKQIKTTNAQEAEAAIRCLLEA----------RGGASEEALSAVAPRDLE 1204
P + + + T + Q A LL+A + S A V+P
Sbjct: 632 APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 691
Query: 1205 ASSEPE----------PTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEE 1254
S P P+P A+ P +P A P PP P ++ P P+SP
Sbjct: 692 PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSA 751
Query: 1255 QFEQQTVHFTIGPP-----------------ETSVEAPPVVTAPRVPPVPKPRTFQPGKA 1297
+ PP + +APP + P + +P P PG+A
Sbjct: 752 TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQA 811
Query: 1298 AERPSHRKPASDEAPPGAGASVPPPLEAPPL-VPKVPP 1334
PS P S A P A PP L AP L VP PP
Sbjct: 812 PFSPSASLPMSPLATPPPQA--PPVLAAPLLQVPPSPP 847
Score = 50.8 bits (120), Expect = 1e-05
Identities = 92/375 (24%), Positives = 134/375 (35%), Gaps = 68/375 (18%)
Query: 1091 SPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
+P RS R P P P+ M ++S + +GT + R P A
Sbjct: 150 APKRSALSAGARRDTSGPT-PGTPSPAMARRSRA-----AGTE-----VGLPRPAPSARP 198
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210
+PP G K +V + E A R A GG L A R L +S+ P
Sbjct: 199 RPPTE--GPRK--SVSSASEHSTTEPSPAARRRPSAGGG-----LQRPASRSLSSSATPL 249
Query: 1211 PTPGAAKPE---TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGP 1267
+P + P TP+AP + P + A++ P + K +P +GP
Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP-----------ALGP 298
Query: 1268 PETSVEAPPVVTAPRVPPVPKP--------RTFQPGKAAERPSHRKPASDEAPP------ 1313
+S A P + + PVP P T P P P S APP
Sbjct: 299 LSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLP 358
Query: 1314 ---------GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSS 1364
+ PP++APP + +PP + + + LQ S L S
Sbjct: 359 SPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL 418
Query: 1365 DSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKL 1424
SP+ A + + +S TSP + P++ PL Q P +L P L
Sbjct: 419 GSPT--LQATHSFLTMSPRQTQASLTSPSRPA--STPPDSPPL----QAPL-SLPASPPL 469
Query: 1425 LNNTWLSKSSDPLDS 1439
T LS + PL S
Sbjct: 470 --QTSLSPAVSPLSS 482
Score = 49.3 bits (116), Expect = 3e-05
Identities = 68/291 (23%), Positives = 100/291 (34%), Gaps = 38/291 (13%)
Query: 1096 LSVPNRPRPPQPPQRPP--PPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
L P P PP PP + P PP V SA+ S + + + ++ P P PP
Sbjct: 661 LQAPFSP-PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL----QVPPSPPASPP 715
Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
+ + P + Q + A P A+ P P
Sbjct: 716 MSPSATPPPQAPPPLAAPPLQVPPSP----------------PASPPMSPSATPPPRVPP 759
Query: 1214 GAAKP--ETPQAPPL------LPRRPPPRVPAIKKPTLRRTGKPLS--PEEQFEQQTVHF 1263
A P + P +PP L + PP PA+ P L+ P + P + +
Sbjct: 760 LLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 819
Query: 1264 TIGPPETSV-EAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322
+ P T +APPV+ AP + P P +A RP P + + P ++ P
Sbjct: 820 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP- 878
Query: 1323 LEAPPLVPKVPPRRKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
PP P P S P A H S + L+G + PP
Sbjct: 879 --GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 927
Score = 42.0 bits (97), Expect = 0.004
Identities = 97/383 (25%), Positives = 135/383 (35%), Gaps = 95/383 (24%)
Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGA--PQQPPKARTGI 1159
PRPP P RPPPP V +A ++G G+ + + A + GA P+ P+A
Sbjct: 27 PRPPGSP-RPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA---- 77
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
++ A R RG AP S P +PG A
Sbjct: 78 ------GPTRSAGTSSRNPASRPPASGRGER--------APPAKNTSPGPVSSPGRASGT 123
Query: 1220 TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEA-PPVV 1278
T RP P L + G +S EE + T P +++ A
Sbjct: 124 T---------RPGP---------LGQKGLRISAEETVARGKA--TEAPKRSALSAGARRD 163
Query: 1279 TAPRVPPVPKPRTFQPGKAA------ERPSHRKPASDEAPP--GAGASVPPPLEAPPLVP 1330
T+ P P P + +AA RP+ P++ PP G SV E P
Sbjct: 164 TSGPTPGTPSPAMARRSRAAGTEVGLPRPA---PSARPRPPTEGPRKSVSSASEHSTTEP 220
Query: 1331 KVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSAT 1390
RR+ SA +S L T SS + SG P A GT P+ + + +
Sbjct: 221 SPAARRRPSAGGGLQRPASRS---LSSSATPLSSPARSG-PSARGT--PR----APAHPS 270
Query: 1391 SPDSDGTKAMKP--------EAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTR 1442
P G +A++P +AAP LG S + P SGT
Sbjct: 271 QPKPKGLQALRPPQVTPPRKDAAPALGPLSS-----------------SPLATPSPSGT- 312
Query: 1443 SPKRDPIDPVSAGASAAKAELPP 1465
K P+ P A+ A LPP
Sbjct: 313 --KARPVPPPDNAATPLPATLPP 333
Score = 31.2 bits (69), Expect = 7.8
Identities = 75/286 (26%), Positives = 100/286 (34%), Gaps = 47/286 (16%)
Query: 1051 APPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSP-SRSLSVPNRPRPPQPPQ 1109
+PP+ P K P L+ F ++P S S S+P P PPQ
Sbjct: 771 SPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830
Query: 1110 RPPPPTGLMVKKSAS-------DASISSGTHGQYSILQTARL-LPGAPQQPPKARTGISK 1161
PP +++ S A T G + + RL L AP PP S
Sbjct: 831 APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 890
Query: 1162 PYNVKQIKTTNAQEAEAAIRCLLEARG--GASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
+ + A + +A E RG E +A P D E ++ P + P
Sbjct: 891 TLSGPDL----AGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA-CHPAAWSRGPA 945
Query: 1220 TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVT 1279
P A P P P PA TG P T++ T G PE++ AP
Sbjct: 946 PPLAFRGAPGAPLPWPPA--------TG----PGSADGLCTIYETEG-PESATPAPGA-- 990
Query: 1280 APRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEA 1325
+ P P P T GKAA A GAGAS P +A
Sbjct: 991 ---LDPGPSPGT-SGGKAA------------AGAGAGASSRSPKQA 1020
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 60.5 bits (145), Expect = 1e-08
Identities = 73/277 (26%), Positives = 102/277 (36%), Gaps = 41/277 (14%)
Query: 1093 SRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQP 1152
S + P +P P++ PP V K +++ +P P+ P
Sbjct: 10446 SEKIIPPKKPPTKVVPRKEPPAKVPEVPKKI--------------VVEEKVRVPEEPRVP 10491
Query: 1153 PKARTGISKPYNV---KQIKTTNAQEAEAAIRCLLEA-RGGASEEALSAVAPRDLEASSE 1208
P + P V K++ A++ EA + EA + E+ + P+ E
Sbjct: 10492 PTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT 10551
Query: 1209 PEP-TPGAAKPE--TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI 1265
P P AA PE P+A P P PPP VP K + P +P ++ E V
Sbjct: 10552 KVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPE 10611
Query: 1266 GP----PETSVEAP----PVVTAPRVPPVPK---PRTFQPGKAAERPSHRKPASDEAPPG 1314
P PE V P P V +VP VPK P P +P P E P
Sbjct: 10612 APKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEE 10671
Query: 1315 AGASVPP------PLEAPPLVPKVPPRR---KKSAPA 1342
PP P A P VPP++ +K APA
Sbjct: 10672 VALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPA 10708
Score = 58.9 bits (141), Expect = 4e-08
Identities = 93/383 (24%), Positives = 147/383 (38%), Gaps = 75/383 (19%)
Query: 998 EENFDFTSLDYESEGDILEDDEDY-LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKS 1056
EE ++ DY+ E + E E+Y +E+ + E + +++ P + P +
Sbjct: 9743 EEYEEYEEYDYK-EFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEE 9801
Query: 1057 PALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTG 1116
P TK K P K +AV E + P +P + +PP PP+ P P
Sbjct: 9802 PVPTKPKAPPA----------KVLKKAVPEEKVPVP-----IPKKLKPP-PPKVPEEPKK 9845
Query: 1117 LMVKKSASDASISSGTHGQYSILQTARLLPGAP------QQPPKARTGISKPYNVKQIK- 1169
+ +K IS + + + A +P P ++ P R ++ P V ++
Sbjct: 9846 VFEEK----IRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPK 9901
Query: 1170 -------------TTNAQE--AEAAIRCLLEARGGASEEALSAVAPRDLE------ASSE 1208
T+ +E E + E +EE + V P + E
Sbjct: 9902 ELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEE 9961
Query: 1209 PEPTPGAAKPETPQAP-PLLPRRPPPRVPAI--KKPTLRRTGKPLSPEEQFEQQTVHFTI 1265
+P P K E P A P +P++P +VP + KK P P++ ++ V
Sbjct: 9962 KKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPV-- 10019
Query: 1266 GPPETSVEAPPVVTAPRVPP---------VPKPRTFQ--PGKAAERPSHRKPASDEAPPG 1314
P VEAPP P VP VP P+ + P K E P P + P
Sbjct: 10020 -PVPKKVEAPPA-KVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTP- 10076
Query: 1315 AGASVPPPLEAPPLVPKVPPRRK 1337
VP +EAPP PKVP +R+
Sbjct: 10077 ----VPKKVEAPP--PKVPKKRE 10093
Score = 56.2 bits (134), Expect = 2e-07
Identities = 74/320 (23%), Positives = 112/320 (35%), Gaps = 54/320 (16%)
Query: 1052 PPSKSPALTK----KKQHPTY---KDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRP 1104
PP+K P + K +K+ P K ++ E+ E E V P+ + P P
Sbjct: 10633 PPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVA--LEEPPAEVVEEPEPAAP 10690
Query: 1105 PQ---PPQRPPP----PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
PQ PP++P P P + K + + ++P P+ PP
Sbjct: 10691 PQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVP 10750
Query: 1158 GISK-----------------PYNVKQIKTTNAQEAEAAIRCLLEARGGASE--EALSAV 1198
+ K P V ++ E + A+ A E E +
Sbjct: 10751 EVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEI 10810
Query: 1199 APRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQ 1258
AP + A E +P P A + E PP +P P +P K P +++ P E +
Sbjct: 10811 APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPE--- 10867
Query: 1259 QTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGAS 1318
PE +E P + P PP P+ K + + K E P
Sbjct: 10868 ---------PEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKP-----Q 10913
Query: 1319 VPPPLEAPPLVPKVPPRRKK 1338
VP +E PL KVP KK
Sbjct: 10914 VPEKVELTPL--KVPGGEKK 10931
Score = 55.8 bits (133), Expect = 3e-07
Identities = 78/332 (23%), Positives = 122/332 (36%), Gaps = 63/332 (18%)
Query: 1008 YESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPT 1067
YE +I ++E +E P + E + P + P K P + K + P
Sbjct: 10804 YEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPP 10863
Query: 1068 YKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDAS 1127
+ + + V K +L +PRPP PP P PP + +K +
Sbjct: 10864 KEPEPEKVIEKPKL-------------------KPRPPPPP--PAPPKEDVKEKIFQLKA 10902
Query: 1128 ISSGTHGQYSILQTARLLPGAPQQPPKAR-TGISKPYNVKQIKTTNAQ-----EAEAAIR 1181
I + +P PQ P K T + P K+++ + + E ++
Sbjct: 10903 IPK------------KKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLK 10950
Query: 1182 CLLEARGGASEEALSAVAPRDLEASSEPE-PTPGAAKPETPQAPPLLPRRP-----PPRV 1235
+L R EE V P+ LE +P P P KP P + +R P +V
Sbjct: 10951 SVLRKR---PEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKV 11007
Query: 1236 PAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPG 1295
P IK P + P+ + E +T+ PP E P+ VP V G
Sbjct: 11008 PEIK-PAIPLPAPEPKPKPEAEVKTIK----PPPVEPEPTPIAAPVTVPVV--------G 11054
Query: 1296 KAAERPSHRKPASDEAPP--GAGASVPPPLEA 1325
K AE + ++ A+ P G P P+EA
Sbjct: 11055 KKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEA 11086
Score = 54.3 bits (129), Expect = 9e-07
Identities = 66/261 (25%), Positives = 93/261 (35%), Gaps = 57/261 (21%)
Query: 1092 PSRSLSVPNRPRPPQPPQRPPP-PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
P + + VP +P PP + P P + +K +A +P P+
Sbjct: 10534 PEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEA------------------IPPKPE 10575
Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL-EASSE- 1208
PP + EA + E + A+ V P + EA E
Sbjct: 10576 SPPP-------------------EVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEV 10616
Query: 1209 -PEPTPGAAKPETPQAPPL-LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
PE P+ P+ PP +P P VP K P P E FE+
Sbjct: 10617 VPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEE 10676
Query: 1267 PPETSVE-----APPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP 1321
PP VE APP VT P PVP+ + P A++P E PP VP
Sbjct: 10677 PPAEVVEEPEPAAPPQVTVPPKKPVPEKKA--PAVVAKKP--------ELPPVKVPEVPK 10726
Query: 1322 PLEAPPLVPKVPPRRKKSAPA 1342
+ VP V P++ ++ PA
Sbjct: 10727 EVVPEKKVPLVVPKKPEAPPA 10747
Score = 52.8 bits (125), Expect = 3e-06
Identities = 74/310 (23%), Positives = 119/310 (38%), Gaps = 30/310 (9%)
Query: 1044 VPGPTA-LAPPSKSPALTKKKQHPTYKDDADLVELKRE--LEAVGEFRHRS--------- 1091
VP P +APP + P + K+ + + ++V E +E E+ H
Sbjct: 9883 VPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEV 9942
Query: 1092 -PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
P + VP PR P P ++ P P + KK A A + + L+P +
Sbjct: 9943 VPVIPVKVPEVPRKPVPEEKKPVP--VPKKKEAPPAKVPEVPKKPEEKVPV--LIPKKEK 9998
Query: 1151 QPP-KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEA-RGGASEEALSAVAPRDLEASSE 1208
PP K KP +++ ++ EA + E + E+ + AP+ +EA
Sbjct: 9999 PPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPA 10058
Query: 1209 PEP-TPGAAKPETPQAPPLLPRR---PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
P P PE + P+ P++ PPP+VP ++P P E FE++ V
Sbjct: 10059 KVPEVPKKLIPEEKKPTPV-PKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIV--- 10114
Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRK-PASDEAPPGAGASVPPPL 1323
P E + V +P+ P + P + P +E P VP
Sbjct: 10115 --PEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEE 10172
Query: 1324 EAPPLVPKVP 1333
P + PKVP
Sbjct: 10173 VLPEVKPKVP 10182
Score = 51.6 bits (122), Expect = 6e-06
Identities = 62/208 (29%), Positives = 82/208 (39%), Gaps = 22/208 (10%)
Query: 1146 PGAPQQPPKARTGI----SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEA------L 1195
P AP + P+ I P V K A+ E + ++E + EE +
Sbjct: 10436 PKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKV 10495
Query: 1196 SAVAPRDLEASSEPEPTPGAAKPET-----PQAP-PLLPRRPPPRVPAIKKPTLRRTGKP 1249
V P + P P A KPE P+AP ++P + P VP KKP + T P
Sbjct: 10496 PEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVP-VPPPKKPEVPPTKVP 10554
Query: 1250 LSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPR-VPPVPKPRTFQPGKAAERPSHRKPAS 1308
P+ ++ V I PP+ P V AP+ V P K P K P A
Sbjct: 10555 EVPKAAVPEKKVPEAI-PPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAP 10613
Query: 1309 DEAPPGAGASVPPPL--EAPPL-VPKVP 1333
E P VPPP E PP VP+VP
Sbjct: 10614 KEVVPEKKVPVPPPKKPEVPPTKVPEVP 10641
Score = 48.9 bits (115), Expect = 4e-05
Identities = 40/143 (27%), Positives = 54/143 (37%), Gaps = 11/143 (7%)
Query: 1209 PEPTPGAAKPETPQAPPLLPRRPPPR----VPAIKK-----PTLRRTGKPLSPEEQFEQQ 1259
P P P +P P+ P + P++P P VP KK P + K PEE+
Sbjct: 9302 PVPIPKKVEPPAPKVPEV-PKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP 9360
Query: 1260 TVHFTIGPPETSVEAPP-VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGAS 1318
PP E VVT ++ V + P E P + P + P
Sbjct: 9361 VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEE 9420
Query: 1319 VPPPLEAPPLVPKVPPRRKKSAP 1341
VPPP + P L K P K + P
Sbjct: 9421 VPPPPKVPALPKKPVPEEKVAVP 9443
Score = 48.1 bits (113), Expect = 6e-05
Identities = 63/291 (21%), Positives = 105/291 (36%), Gaps = 26/291 (8%)
Query: 1062 KKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP-PQRPPPPTGLMVK 1120
++ PT + D +RE E E +P +P P +P P +P P ++K
Sbjct: 9757 EEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLK 9816
Query: 1121 KSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAI 1180
K+ + + + +L P P+ P + + + + K Q E A
Sbjct: 9817 KAVPEEKVP--------VPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAA 9868
Query: 1181 RCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETP-QAPPLLPRRPPPRVPAIK 1239
+ ++ + +EE + PR E P PE P + P V ++
Sbjct: 9869 KVPMKPKRVVAEEKVPV--PRK-------EVAPPVRVPEVPKELEPEEVAFEEEVVTHVE 9919
Query: 1240 KPTLRRTGKPLSPEEQFEQQTVHFTIGPPET-SVEAPPVVTAPRVPPVPKPRTFQPGKAA 1298
+ + + + EE+F + + P + V PV + PVPK + P K
Sbjct: 9920 EYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVP 9979
Query: 1299 E---RPSHRKPA---SDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAA 1343
E +P + P E PP A P P VP +K AP A
Sbjct: 9980 EVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPA 10030
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/134 (29%), Positives = 52/134 (38%), Gaps = 17/134 (12%)
Query: 1219 ETPQAPPLLPRRPPPRVPAIKKPT--LRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPP 1276
E P+APP P +P K PT + R P E ++ V + PE P
Sbjct: 10434 EKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPE-----EP 10488
Query: 1277 VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPL-------EAPPLV 1329
V +VP V P+ P K P +KP EAPP P + PP
Sbjct: 10489 RVPPTKVPEVLPPKEVVPEKKVPVPPAKKP---EAPPPKVPEAPKEVVPEKKVPVPPPKK 10545
Query: 1330 PKVPPRRKKSAPAA 1343
P+VPP + P A
Sbjct: 10546 PEVPPTKVPEVPKA 10559
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/153 (28%), Positives = 60/153 (39%), Gaps = 18/153 (11%)
Query: 1193 EALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP 1252
E + + R E + P +K PQ P P + V +K P + +S
Sbjct: 9187 EKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQE--EVIEVKVPAVHTKKMVISE 9244
Query: 1253 EEQF----EQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPAS 1308
E+ F ++ V T+ PE E +VT ++ R P K E P KPA
Sbjct: 9245 EKMFFASHTEEEVSVTV--PEVQKE---IVTEEKIHVAISKRVEPPPKVPELPE--KPAP 9297
Query: 1309 DEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341
+E P VP P + P PKVP KK P
Sbjct: 9298 EEVAP-----VPIPKKVEPPAPKVPEVPKKPVP 9325
Score = 42.0 bits (97), Expect = 0.004
Identities = 77/329 (23%), Positives = 122/329 (37%), Gaps = 63/329 (19%)
Query: 1044 VPGPTAL-APPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRP 1102
VP P + APP+K P + KK ++ + +++EA P
Sbjct: 10047 VPAPKKVEAPPAKVPEVPKK----LIPEEKKPTPVPKKVEA------------------P 10084
Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKP 1162
P P +R P P + + + + + + +LP + P+ + +
Sbjct: 10085 PPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEE 10144
Query: 1163 YNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQ 1222
+ + E E E EE L V P+ P P P K T +
Sbjct: 10145 EEIPPEEEEVPPEEEYVPE---EEEFVPEEEVLPEVKPK----VPVPAPVPEIKKKVT-E 10196
Query: 1223 APPLLPRR---PPPRVPAI-KKPTLRRTGKPLSPE-------EQFEQQTVHFTIGPPET- 1270
++P++ PP +VP + KK +R P E E+ E++ + P E
Sbjct: 10197 KKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP 10256
Query: 1271 SVEAPPVVTAPRVP------------PVPKPRTFQPGKAAER-PSHRKPA---SDEAPPG 1314
S+E V PRVP PVPK P K +++ P + P EAPP
Sbjct: 10257 SIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPA 10316
Query: 1315 AGASVPPPL-EAPPLVPK---VPPRRKKS 1339
VP + E LVPK VPP + ++
Sbjct: 10317 KVPEVPKKVPEKKVLVPKKEAVPPAKGRT 10345
Score = 41.2 bits (95), Expect = 0.008
Identities = 81/352 (23%), Positives = 130/352 (36%), Gaps = 71/352 (20%)
Query: 1044 VPGPTAL---APPSKSPALTK------KKQHPTYKDDAD---LVELKRELEAVGEFRHRS 1091
+P P A APP+K P + K K T ++++ + E+ ++ V E R
Sbjct: 9357 IPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKK--KVPEERKPV 9414
Query: 1092 PSRSLSVPNRPRPPQPPQRPPP------PTGLMVKKSASDASISSGT-HGQYSILQTARL 1144
P + VP P+ P P++P P P + K A +S T + + +L
Sbjct: 9415 PRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKL 9474
Query: 1145 LPGAPQQPPKARTGIS-----------KPYNVKQIKTTNAQEAEAA----IRCLLEARGG 1189
PQ+ R +S + ++ + +E E A + E
Sbjct: 9475 SFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEY 9534
Query: 1190 ASEEALSAVAPRDLEASSEPEPTPGAAKPE-----TPQAPPLLPRRPPPRVPAIKKPTL- 1243
EE L ++ R E EP + E P+ P + PP +VP K +
Sbjct: 9535 VVEEKLHIISKR-----VEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVP 9589
Query: 1244 -RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPP-VPKPRTFQPGKAAERP 1301
++ P+ +E+ + PP+ E V +VPP V K P K ER
Sbjct: 9590 EKKVPAPVPKKEK---------VPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTER- 9639
Query: 1302 SHRKPASD----------EAPPGAGASVPPPLEAP-PLVPKVPPRRKKSAPA 1342
H + + EAPP A P P V K+ P+R++ PA
Sbjct: 9640 -HMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPA 9690
Score = 40.4 bits (93), Expect = 0.013
Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 11/117 (9%)
Query: 1203 LEASSEPEPTPGAAKPETPQAPPLLPRRP---PPRVPAIKKPTLRRTGKPL-----SPEE 1254
+E + EPE P ++ E P+ PP + PPRVP + K + P+ +P
Sbjct: 10235 VEVTEEPEEEP-ISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPA 10293
Query: 1255 QFEQQTVHFTIGPPETSVEAPPVVTAPRVP-PVPKPRTFQPGKAAERPSHRKPASDE 1310
+ ++ + P EAPP P VP VP+ + P K A P+ + +E
Sbjct: 10294 KVSKKIPEEKVPVPVQKKEAPP-AKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEE 10349
Score = 38.9 bits (89), Expect = 0.038
Identities = 78/385 (20%), Positives = 125/385 (32%), Gaps = 98/385 (25%)
Query: 1039 DDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSV 1098
++++ VP P + PP+ KK P K + + + P+ V
Sbjct: 9298 EEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPK-------------KEPAAPPKV 9344
Query: 1099 PNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHG----QYSILQTAR------LLPGA 1148
P P+ P P ++ P P + KK A A + G + + T R +P
Sbjct: 9345 PEVPKKPVPEEKIPVP--VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEI 9402
Query: 1149 PQQ------------------PPKARTGISKPYNVKQI-------KTTNAQEAEAAIRCL 1183
P++ PPK KP +++ K AE + + +
Sbjct: 9403 PKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTV 9462
Query: 1184 LEARGGASEEALSAVAPRDLEAS----------SEPEPTPGAA----------KPETPQA 1223
+E + +EE LS P+ +E + S E G + + E +
Sbjct: 9463 VEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEV 9522
Query: 1224 PPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPP-ETSVEAPPVVTAPR 1282
P +K + P E E+Q + P +E PP P
Sbjct: 9523 TEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPE 9582
Query: 1283 VP-----------PVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPK 1331
P PVPK P K E P +KP ++ P + PL A K
Sbjct: 9583 APKKIVPEKKVPAPVPKKEKVPPPKVPEEP--KKPVPEKKVPPKVIKMEEPLPA-----K 9635
Query: 1332 VPPRRKKSAPAAFHLQVLQSNSQLL 1356
V R H+Q+ Q L+
Sbjct: 9636 VTER---------HMQITQEEKVLV 9651
Score = 37.0 bits (84), Expect = 0.14
Identities = 75/354 (21%), Positives = 125/354 (35%), Gaps = 56/354 (15%)
Query: 1010 SEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSD-----------VPGPTALAPPSKSPA 1058
+E +++E+ E+Y+V+E E ++++ +P PP+K P
Sbjct: 9523 TEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPE 9582
Query: 1059 LTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM 1118
KK +V K+ V + P + VP P+ P P ++ PP +
Sbjct: 9583 APKK-----------IVPEKKVPAPVPKKEKVPPPK---VPEEPKKPVPEKKVPPK---V 9625
Query: 1119 VKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNV---KQIKTTNAQE 1175
+K + + H Q + + + + PPKAR V K +K +E
Sbjct: 9626 IKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKRE 9685
Query: 1176 AEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRV 1235
E + + EE +S AP+ EP+P E + L V
Sbjct: 9686 EEPPAKVTEFRKRVVKEEKVSIEAPK-----REPQPIKEVTIMEEKERAYTLEEE---AV 9737
Query: 1236 PAIKKPTLR-------RTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVP---- 1284
++ + + P E+++Q + E E +T P P
Sbjct: 9738 SVQREEEYEEYEEYDYKEFEEYEPTEEYDQYE-EYEEREYERYEEHEEYITEPEKPIPVK 9796
Query: 1285 PVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKK 1338
PVP+ KA +K +E P VP P + P PKVP KK
Sbjct: 9797 PVPEEPVPTKPKAPPAKVLKKAVPEEKVP-----VPIPKKLKPPPPKVPEEPKK 9845
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 60.5 bits (145), Expect = 1e-08
Identities = 82/322 (25%), Positives = 117/322 (36%), Gaps = 55/322 (17%)
Query: 1090 RSPSRSLSVPNRPRPP-----QPPQRPPP------------------PTGLMVKKSASDA 1126
R R+ + P++P+P +PPQ PP P+ +S +
Sbjct: 260 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP 319
Query: 1127 SISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEA 1186
++ + H Q A LP AP P S P +++ + + A A L
Sbjct: 320 TLPATPHSSSLTCQLATPLPLAPPSP-------SAPPSLQTLPSPPATPPSQATTSL--- 369
Query: 1187 RGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL---PRRPPPRVPAIKKPTL 1243
G + +A + P P +P A P PQAPP L P + PP PA +
Sbjct: 370 -GSPTLQATHSFLP-------SPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSP 419
Query: 1244 RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAP-PVVTAPRVPPVPKPRTFQPGKAAERPS 1302
T P +P PP V+AP +P V P P + P A P
Sbjct: 420 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 479
Query: 1303 HRKPASDEAPPGAGASVPPPL-----EAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQ 1357
P+ +PP + ++ PPP APPL PP + A A LQ L S
Sbjct: 480 QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539
Query: 1358 GLTYNSSDSPSGHPPAAGTVFP 1379
G + SPS P + P
Sbjct: 540 G---QAPFSPSASLPMSPLATP 558
Score = 57.4 bits (137), Expect = 1e-07
Identities = 82/338 (24%), Positives = 112/338 (33%), Gaps = 28/338 (8%)
Query: 1047 PTALAPPSKS--PALTKKKQHPTYKDDADLVEL-KRELEAVGEFRHRSPSRSLSVPNRPR 1103
P LAPPS S P+L P L L+A F P L+ P
Sbjct: 337 PLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396
Query: 1104 PPQ----PPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
PP P Q PP P + S + +LQ P +P
Sbjct: 397 PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 456
Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
S P + + A + AA + AS P TP P
Sbjct: 457 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SPSATPPPQAPP 503
Query: 1220 TPQAPPLLPRRPPPRVP-AIKKPTLRRTGKPLS--PEEQFEQQTVHFTIGPPETSV-EAP 1275
APPL +PPP+ P A+ P L+ P + P + + + P T +AP
Sbjct: 504 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 563
Query: 1276 PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335
PV+ AP + P P +A RP P + + P ++ P PP P P
Sbjct: 564 PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPS 620
Query: 1336 RKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
S P A H S + L+G + PP
Sbjct: 621 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 658
Score = 43.9 bits (102), Expect = 0.001
Identities = 92/385 (23%), Positives = 123/385 (31%), Gaps = 89/385 (23%)
Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGA--PQQPPKA---- 1155
PRPP P RPPPP V +A ++G G+ + + A + GA P+ P+A
Sbjct: 27 PRPPGSP-RPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTR 81
Query: 1156 ------RTGISKP------YNVKQIKTTN----------------AQEAEAAIRCLLE-- 1185
R S+P K T+ + +R E
Sbjct: 82 SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141
Query: 1186 -ARGGASE----EALSAVAPRDLEASSEPEPTPGAAKPE--------TPQAPPLLPRRPP 1232
ARG A+E ALSA A RD + P+P A+ P+ P RPP
Sbjct: 142 VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 201
Query: 1233 PRVP------------AIKKPTLRRT----GKPLSPEEQFEQQTVHFTIGPPETSVEAPP 1276
P P RR G P + + P + A
Sbjct: 202 TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARG 261
Query: 1277 VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPL-----------EA 1325
AP P PKP+ G A RP P +A P G PL +A
Sbjct: 262 TPRAPAHPSQPKPK----GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQA 317
Query: 1326 PPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385
PP +P P + A L + + L + SP PP+ T L
Sbjct: 318 PPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSL--QTLPSPPATPPSQATTSLGSPTLQ 375
Query: 1386 T--SSATSPDSDGTKAMKPEAAPLL 1408
S SP P+A P L
Sbjct: 376 ATHSFLPSPPLSPLATPPPQAPPAL 400
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,866,620
Number of Sequences: 37866
Number of extensions: 3423158
Number of successful extensions: 34350
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 1175
Number of HSP's that attempted gapping in prelim test: 20298
Number of HSP's gapped (non-prelim): 9385
length of query: 1496
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1381
effective length of database: 13,892,928
effective search space: 19186133568
effective search space used: 19186133568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.