Guide to the Human Genome
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Search of human proteins with 26190608

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|26190608 synaptojanin 2 [Homo sapiens]
         (1496 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|26190608 synaptojanin 2 [Homo sapiens]                            3025   0.0  
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                 1187   0.0  
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                 1175   0.0  
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                 1174   0.0  
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                 1171   0.0  
gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso...   223   1e-57
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso...   223   1e-57
gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs...   206   1e-52
gi|190014578 suppressor of actin 1 [Homo sapiens]                     190   1e-47
gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens]      179   1e-44
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas...   179   2e-44
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ...   155   2e-37
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ...   155   2e-37
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap...   153   1e-36
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]     139   2e-32
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho...   129   3e-29
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H...   123   2e-27
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho...   123   2e-27
gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo sa...   105   3e-22
gi|47132519 Ras association and pleckstrin homology domains 1 is...    69   4e-11
gi|153792074 proline rich 12 [Homo sapiens]                            67   1e-10
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   67   1e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   67   1e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   67   1e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    67   1e-10
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     65   5e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    64   8e-10
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    62   4e-09
gi|110349719 titin isoform N2-A [Homo sapiens]                         60   1e-08
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    60   1e-08

>gi|26190608 synaptojanin 2 [Homo sapiens]
          Length = 1496

 Score = 3025 bits (7843), Expect = 0.0
 Identities = 1496/1496 (100%), Positives = 1496/1496 (100%)

Query: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
            MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA
Sbjct: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60

Query: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
            YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL
Sbjct: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120

Query: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
            KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW
Sbjct: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180

Query: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
            LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY
Sbjct: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240

Query: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
            MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV
Sbjct: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300

Query: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
            VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH
Sbjct: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360

Query: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 420
            WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV
Sbjct: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 420

Query: 421  DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 480
            DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA
Sbjct: 421  DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 480

Query: 481  IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 540
            IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN
Sbjct: 481  IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 540

Query: 541  GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 600
            GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS
Sbjct: 541  GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 600

Query: 601  TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 660
            TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG
Sbjct: 601  TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 660

Query: 661  KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 720
            KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY
Sbjct: 661  KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 720

Query: 721  VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 780
            VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY
Sbjct: 721  VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 780

Query: 781  KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 840
            KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG
Sbjct: 781  KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 840

Query: 841  ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 900
            ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT
Sbjct: 841  ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 900

Query: 901  LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960
            LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA
Sbjct: 901  LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960

Query: 961  VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 1020
            VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED
Sbjct: 961  VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 1020

Query: 1021 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1080
            YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE
Sbjct: 1021 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1080

Query: 1081 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1140
            LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ
Sbjct: 1081 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1140

Query: 1141 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200
            TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP
Sbjct: 1141 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200

Query: 1201 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1260
            RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT
Sbjct: 1201 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1260

Query: 1261 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1320
            VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP
Sbjct: 1261 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1320

Query: 1321 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1380
            PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ
Sbjct: 1321 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1380

Query: 1381 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1440
            GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG
Sbjct: 1381 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1440

Query: 1441 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1496
            TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT
Sbjct: 1441 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1496


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 1187 bits (3070), Expect = 0.0
 Identities = 642/1400 (45%), Positives = 899/1400 (64%), Gaps = 91/1400 (6%)

Query: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
            MA SKG R+  +L      S+++E R +++CL+FE+G VA L+  EKE IKG Y K+ DA
Sbjct: 1    MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59

Query: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
            YG LG LRL  G T L +LVLVTGC SVG+I ++E++++T+T+F  L+ ++ +E+R+  +
Sbjct: 60   YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119

Query: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
            +K+L+SG FYF+W   G   DL++   +   + +   N FFWNQ LH+ L+ + V+C DW
Sbjct: 120  RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178

Query: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
            LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 179  LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238

Query: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
            +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH   LK  YG+Q++
Sbjct: 239  LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298

Query: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
            VNLLGS+ GE +L++AF+  L AS HA D  M+NFD+HQ  KGGK EKL ++L+PQ++  
Sbjct: 299  VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357

Query: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
            + D+  F    +   R Q GT+R NCLDCLDRTN+VQ+F+ LE+L  QL+ LGL+ KP +
Sbjct: 358  FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417

Query: 420  VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
            V RF E F++MWS+NG S+SK++ G+ ALEGKAK GKLKDGARS++RTIQ+NFFD  KQE
Sbjct: 418  VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKAGKLKDGARSVTRTIQNNFFDSSKQE 477

Query: 480  AIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNV 539
            AI +LL+G+    ++ADK   LL + +L  + ++LK+M E   +++  K+IR+ +GTWNV
Sbjct: 478  AIDVLLLGNTLNSDLADKARALLTTGSLRASSKVLKSMCENFYKYSKPKKIRVCVGTWNV 537

Query: 540  NGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVELSAGNIVN 598
            NGGKQFRS   +   LTDWLLD+P+L+G  + QD  S P DIFA+GFEEMVEL+AGNIV+
Sbjct: 538  NGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVS 597

Query: 599  ASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGM 658
            ASTTN+K+W  +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA+DTVKTGM
Sbjct: 598  ASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGM 657

Query: 659  GGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSH 718
            GG  GNKGAV IR  FH+TS CF+CSH  AGQSQVKERNED+ EI +KL FPMGR +FSH
Sbjct: 658  GGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSH 717

Query: 719  DYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGP 778
            DYVFWCGDFNYRIDL  EEV   +++Q+W  L+  DQL  QK++G++F+ F EG + F P
Sbjct: 718  DYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAP 777

Query: 779  TYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWS 838
            TYKYD+ S  YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++    ++K+ +TW+
Sbjct: 778  TYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWT 837

Query: 839  PGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS 898
            PG L +YGRAEL+ SDHRPV+A++++++ EV+   R+ +++EV + QGP D TV+V+++S
Sbjct: 838  PGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKS 897

Query: 899  PTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKG 958
             +L E N F + L  EL+Q   S+G ++L+R  + +M VTF +  SAL+VL ++G ++  
Sbjct: 898  -SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLN 956

Query: 959  RAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDD 1018
            R + I  K+ DW+K L EE+  ++ S+A  S T+++ L E+       D E + D    +
Sbjct: 957  RTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAE 1016

Query: 1019 EDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSPALT----K 1061
             + L+ +  QP  S S LG                +S+ P P+    PS++P+ T     
Sbjct: 1017 VEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1075

Query: 1062 KKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKK 1121
             +  P     A  +  K   + + E +   P R ++ P R   P PPQRPPPP+G    +
Sbjct: 1076 AQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPPPSGR--SQ 1129

Query: 1122 SASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIR 1181
             +  A ++      YS   TAR     P  PP+A            I    +    +A R
Sbjct: 1130 PSPQAGLAGPGPAGYS---TAR-----PTIPPRAGV----------ISAPQSHARASAGR 1171

Query: 1182 CLLEARGGASEEAL-SAVAPRDLE-------ASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233
               E++   SE +  S   P  L+        SS P P     +P  P A P+    P P
Sbjct: 1172 LTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQP 1231

Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQ---QTVHFTIGPPETSVEAPP-------------V 1277
             +    +P  R       P E   Q   +T   + G  E+ ++  P              
Sbjct: 1232 NLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKA 1291

Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRK 1337
              + +  PVP P    P +  + PS              ++V   +   P +P +P R +
Sbjct: 1292 QLSVQTSPVPTP---DPKRLIQLPS-----------ATQSNVLSSVSCMPTMPPIPARSQ 1337

Query: 1338 -----KSAPAAFHLQVLQSN 1352
                 +S+P  F   + ++N
Sbjct: 1338 SQENMRSSPNPFITGLTRTN 1357


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score = 1175 bits (3039), Expect = 0.0
 Identities = 630/1349 (46%), Positives = 878/1349 (65%), Gaps = 81/1349 (6%)

Query: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
            MA SKG R+  +L      S+++E R +++CL+FE+G VA L+  EKE IKG Y K+ DA
Sbjct: 40   MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 98

Query: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
            YG LG LRL  G T L +LVLVTGC SVG+I ++E++++T+T+F  L+ ++ +E+R+  +
Sbjct: 99   YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 158

Query: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
            +K+L+SG FYF+W   G   DL++   +   + +   N FFWNQ LH+ L+ + V+C DW
Sbjct: 159  RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 217

Query: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
            LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 218  LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 277

Query: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
            +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH   LK  YG+Q++
Sbjct: 278  LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 337

Query: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
            VNLLGS+ GE +L++AF+  L AS HA D  M+NFD+HQ  KGGK EKL ++L+PQ++  
Sbjct: 338  VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 396

Query: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
            + D+  F    +   R Q GT+R NCLDCLDRTN+VQ+F+ LE+L  QL+ LGL+ KP +
Sbjct: 397  FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 456

Query: 420  VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
            V RF E F++MWS+NG S+SK++ G+ ALEGKAK   LKDGARS++RTIQ+NFFD  KQE
Sbjct: 457  VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 513

Query: 480  AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531
            AI +LL+G+    ++ADK   LL + +L V+         ++LK+M E   +++  K+IR
Sbjct: 514  AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 573

Query: 532  IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590
            + +GTWNVNGGKQFRS   +   LTDWLLD+P+L+G  + QD  S P DIFA+GFEEMVE
Sbjct: 574  VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 633

Query: 591  LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
            L+AGNIV+ASTTN+K+W  +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 634  LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 693

Query: 651  IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710
            +DTVKTGMGG  GNKGAV IR  FH+TS CF+CSH  AGQSQVKERNED+ EI +KL FP
Sbjct: 694  VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 753

Query: 711  MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770
            MGR +FSHDYVFWCGDFNYRIDL  EEV   +++Q+W  L+  DQL  QK++G++F+ F 
Sbjct: 754  MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813

Query: 771  EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830
            EG + F PTYKYD+ S  YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++    +
Sbjct: 814  EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 873

Query: 831  TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890
            +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+   R+ +++EV + QGP D 
Sbjct: 874  SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 933

Query: 891  TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950
            TV+V+++S +L E N F + L  EL+Q   S+G ++L+R  + +M VTF +  SAL+VL 
Sbjct: 934  TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 992

Query: 951  VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010
            ++G ++  R + I  K+ DW+K L EE+  ++ S+A  S T+++ L E+       D E 
Sbjct: 993  LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1052

Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057
            + D    + + L+ +  QP  S S LG                +S+ P P+    PS++P
Sbjct: 1053 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1111

Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113
            + T      +  P     A  +  K   + + E +   P R ++ P R   P PPQRPPP
Sbjct: 1112 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1167

Query: 1114 PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNA 1173
            P+G         A   + T  ++  +       GAP  P  AR  +  P +    +  N 
Sbjct: 1168 PSG---------ARSPAPTRKEFGGI-------GAPPSPGVARREMEAPKSPGTTRKDNI 1211

Query: 1174 QEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233
              ++ + +  L   G A         P      S P+    A+      A  L P     
Sbjct: 1212 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS------AGRLTPESQSK 1265

Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV-VTAP----------R 1282
                 K  T     +PL P+  F  Q+   ++ PP   ++ P V V AP           
Sbjct: 1266 TSETSKGSTF--LPEPLKPQAAFPPQS---SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1320

Query: 1283 VPPVPKPRTFQ----PGKAAERPSHRKPA 1307
             PP P PR+      P +A+ +P   +P+
Sbjct: 1321 TPPQPPPRSRSSHSLPSEASSQPQQEQPS 1349



 Score = 35.0 bits (79), Expect = 0.54
 Identities = 47/200 (23%), Positives = 66/200 (33%), Gaps = 47/200 (23%)

Query: 1268 PETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP- 1326
            P TS    P ++   VP +P     +P +A  R +   P++  +P  A  + P P + P 
Sbjct: 1085 PRTSPCQSPTISEGPVPSLP----IRPSRAPSR-TPGPPSAQSSPIDAQPATPLPQKDPA 1139

Query: 1327 -PLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385
             PL PK PP  +  AP                         P   PP +G   P      
Sbjct: 1140 QPLEPKRPPPPRPVAPPT-------------------RPAPPQRPPPPSGARSPAPTRKE 1180

Query: 1386 TSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPK 1445
                 +P S G    + EA                 PK    T      D +     SP+
Sbjct: 1181 FGGIGAPPSPGVARREMEA-----------------PKSPGTT----RKDNIGRSQPSPQ 1219

Query: 1446 RDPIDPVSAGASAAKAELPP 1465
                 P  AG S A+  +PP
Sbjct: 1220 AGLAGPGPAGYSTARPTIPP 1239



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 50/240 (20%), Positives = 77/240 (32%), Gaps = 46/240 (19%)

Query: 1170 TTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE--PTPGAAKPETPQAPPLL 1227
            T   ++AE A    +E         +  + P+ L+ SS      +P ++   +P   P +
Sbjct: 1036 TLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTI 1095

Query: 1228 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1287
               P P +P        RT  P S +                + ++A P    P+  P  
Sbjct: 1096 SEGPVPSLPIRPSRAPSRTPGPPSAQS---------------SPIDAQPATPLPQKDPA- 1139

Query: 1288 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVP-------PRRKK-- 1338
                             +P   + PP      PP   APP  P  P       P RK+  
Sbjct: 1140 -----------------QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182

Query: 1339 --SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDG 1396
               AP +  +   +  +    G T   +   S   P AG   P     ST+  T P   G
Sbjct: 1183 GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1242


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 1174 bits (3036), Expect = 0.0
 Identities = 628/1343 (46%), Positives = 873/1343 (65%), Gaps = 69/1343 (5%)

Query: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
            MA SKG R+  +L      S+++E R +++CL+FE+G VA L+  EKE IKG Y K+ DA
Sbjct: 40   MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 98

Query: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
            YG LG LRL  G T L +LVLVTGC SVG+I ++E++++T+T+F  L+ ++ +E+R+  +
Sbjct: 99   YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 158

Query: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
            +K+L+SG FYF+W   G   DL++   +   + +   N FFWNQ LH+ L+ + V+C DW
Sbjct: 159  RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 217

Query: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
            LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 218  LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 277

Query: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
            +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH   LK  YG+Q++
Sbjct: 278  LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 337

Query: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
            VNLLGS+ GE +L++AF+  L AS HA D  M+NFD+HQ  KGGK EKL ++L+PQ++  
Sbjct: 338  VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 396

Query: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
            + D+  F    +   R Q GT+R NCLDCLDRTN+VQ+F+ LE+L  QL+ LGL+ KP +
Sbjct: 397  FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 456

Query: 420  VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
            V RF E F++MWS+NG S+SK++ G+ ALEGKAK   LKDGARS++RTIQ+NFFD  KQE
Sbjct: 457  VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 513

Query: 480  AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531
            AI +LL+G+    ++ADK   LL + +L V+         ++LK+M E   +++  K+IR
Sbjct: 514  AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 573

Query: 532  IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590
            + +GTWNVNGGKQFRS   +   LTDWLLD+P+L+G  + QD  S P DIFA+GFEEMVE
Sbjct: 574  VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 633

Query: 591  LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
            L+AGNIV+ASTTN+K+W  +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 634  LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 693

Query: 651  IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710
            +DTVKTGMGG  GNKGAV IR  FH+TS CF+CSH  AGQSQVKERNED+ EI +KL FP
Sbjct: 694  VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 753

Query: 711  MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770
            MGR +FSHDYVFWCGDFNYRIDL  EEV   +++Q+W  L+  DQL  QK++G++F+ F 
Sbjct: 754  MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813

Query: 771  EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830
            EG + F PTYKYD+ S  YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++    +
Sbjct: 814  EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 873

Query: 831  TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890
            +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+   R+ +++EV + QGP D 
Sbjct: 874  SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 933

Query: 891  TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950
            TV+V+++S +L E N F + L  EL+Q   S+G ++L+R  + +M VTF +  SAL+VL 
Sbjct: 934  TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 992

Query: 951  VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010
            ++G ++  R + I  K+ DW+K L EE+  ++ S+A  S T+++ L E+       D E 
Sbjct: 993  LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1052

Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057
            + D    + + L+ +  QP  S S LG                +S+ P P+    PS++P
Sbjct: 1053 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1111

Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113
            + T      +  P     A  +  K   + + E +   P R ++ P R   P PPQRPPP
Sbjct: 1112 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1167

Query: 1114 PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNA 1173
            P+G         A   + T  ++  +       GAP  P  AR  +  P +    +  N 
Sbjct: 1168 PSG---------ARSPAPTRKEFGGI-------GAPPSPGVARREMEAPKSPGTTRKDNI 1211

Query: 1174 QEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPP 1233
              ++ + +  L   G A         P      S P+    A+      A  L P     
Sbjct: 1212 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS------AGRLTPESQSK 1265

Query: 1234 RVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVP---PVPKPR 1290
                 K  T     +PL P+  F  Q+   ++ PP   ++ P V  A  +P   P P   
Sbjct: 1266 TSETSKGSTF--LPEPLKPQAAFPPQS---SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1320

Query: 1291 TFQPGKAAERPSHRKPASDEAPP 1313
            T        R SH  P+   + P
Sbjct: 1321 TPPQPPPRSRSSHSLPSEASSQP 1343



 Score = 35.0 bits (79), Expect = 0.54
 Identities = 47/200 (23%), Positives = 66/200 (33%), Gaps = 47/200 (23%)

Query: 1268 PETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP- 1326
            P TS    P ++   VP +P     +P +A  R +   P++  +P  A  + P P + P 
Sbjct: 1085 PRTSPCQSPTISEGPVPSLP----IRPSRAPSR-TPGPPSAQSSPIDAQPATPLPQKDPA 1139

Query: 1327 -PLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385
             PL PK PP  +  AP                         P   PP +G   P      
Sbjct: 1140 QPLEPKRPPPPRPVAPPT-------------------RPAPPQRPPPPSGARSPAPTRKE 1180

Query: 1386 TSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPK 1445
                 +P S G    + EA                 PK    T      D +     SP+
Sbjct: 1181 FGGIGAPPSPGVARREMEA-----------------PKSPGTT----RKDNIGRSQPSPQ 1219

Query: 1446 RDPIDPVSAGASAAKAELPP 1465
                 P  AG S A+  +PP
Sbjct: 1220 AGLAGPGPAGYSTARPTIPP 1239



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 50/240 (20%), Positives = 77/240 (32%), Gaps = 46/240 (19%)

Query: 1170 TTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE--PTPGAAKPETPQAPPLL 1227
            T   ++AE A    +E         +  + P+ L+ SS      +P ++   +P   P +
Sbjct: 1036 TLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTI 1095

Query: 1228 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1287
               P P +P        RT  P S +                + ++A P    P+  P  
Sbjct: 1096 SEGPVPSLPIRPSRAPSRTPGPPSAQS---------------SPIDAQPATPLPQKDPA- 1139

Query: 1288 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVP-------PRRKK-- 1338
                             +P   + PP      PP   APP  P  P       P RK+  
Sbjct: 1140 -----------------QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182

Query: 1339 --SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDG 1396
               AP +  +   +  +    G T   +   S   P AG   P     ST+  T P   G
Sbjct: 1183 GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1242


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 1171 bits (3029), Expect = 0.0
 Identities = 628/1341 (46%), Positives = 868/1341 (64%), Gaps = 81/1341 (6%)

Query: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60
            MA SKG R+  +L      S+++E R +++CL+FE+G VA L+  EKE IKG Y K+ DA
Sbjct: 1    MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59

Query: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120
            YG LG LRL  G T L +LVLVTGC SVG+I ++E++++T+T+F  L+ ++ +E+R+  +
Sbjct: 60   YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119

Query: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180
            +K+L+SG FYF+W   G   DL++   +   + +   N FFWNQ LH+ L+ + V+C DW
Sbjct: 120  RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178

Query: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240
            LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 179  LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238

Query: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300
            +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH   LK  YG+Q++
Sbjct: 239  LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298

Query: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360
            VNLLGS+ GE +L++AF+  L AS HA D  M+NFD+HQ  KGGK EKL ++L+PQ++  
Sbjct: 299  VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357

Query: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419
            + D+  F    +   R Q GT+R NCLDCLDRTN+VQ+F+ LE+L  QL+ LGL+ KP +
Sbjct: 358  FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417

Query: 420  VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479
            V RF E F++MWS+NG S+SK++ G+ ALEGKAK   LKDGARS++RTIQ+NFFD  KQE
Sbjct: 418  VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 474

Query: 480  AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531
            AI +LL+G+    ++ADK   LL + +L V+         ++LK+M E   +++  K+IR
Sbjct: 475  AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 534

Query: 532  IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590
            + +GTWNVNGGKQFRS   +   LTDWLLD+P+L+G  + QD  S P DIFA+GFEEMVE
Sbjct: 535  VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 594

Query: 591  LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
            L+AGNIV+ASTTN+K+W  +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 595  LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 654

Query: 651  IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710
            +DTVKTGMGG  GNKGAV IR  FH+TS CF+CSH  AGQSQVKERNED+ EI +KL FP
Sbjct: 655  VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 714

Query: 711  MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770
            MGR +FSHDYVFWCGDFNYRIDL  EEV   +++Q+W  L+  DQL  QK++G++F+ F 
Sbjct: 715  MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 774

Query: 771  EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830
            EG + F PTYKYD+ S  YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++    +
Sbjct: 775  EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 834

Query: 831  TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890
            +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+   R+ +++EV + QGP D 
Sbjct: 835  SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 894

Query: 891  TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950
            TV+V+++S +L E N F + L  EL+Q   S+G ++L+R  + +M VTF +  SAL+VL 
Sbjct: 895  TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 953

Query: 951  VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010
            ++G ++  R + I  K+ DW+K L EE+  ++ S+A  S T+++ L E+       D E 
Sbjct: 954  LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1013

Query: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057
            + D    + + L+ +  QP  S S LG                +S+ P P+    PS++P
Sbjct: 1014 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1072

Query: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113
            + T      +  P     A  +  K   + + E +   P R ++ P R   P PPQRPPP
Sbjct: 1073 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1128

Query: 1114 PTGL---MVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKT 1170
            P+G       +    A  S GT  + +I        G  Q  P+A      P      + 
Sbjct: 1129 PSGARSPAPTRKEFGAPKSPGTTRKDNI--------GRSQPSPQAGLAGPGPAGYSTARP 1180

Query: 1171 TNAQEAEAAIRCLLEARGGA---SEEALSAVAPRDLEASSEPEP-TPGAAKPETPQAPPL 1226
            T    A         AR  A   + E+ S  +     ++  PEP  P AA P     PP 
Sbjct: 1181 TIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPP 1240

Query: 1227 LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPV 1286
              R   P VP                              P   S   P + T P+ PP 
Sbjct: 1241 AQRLQEPLVP---------------------------VAAPMPQSGPQPNLETPPQPPPR 1273

Query: 1287 PKPRTFQPGKAAERPSHRKPA 1307
             +     P +A+ +P   +P+
Sbjct: 1274 SRSSHSLPSEASSQPQQEQPS 1294



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 52/221 (23%), Positives = 78/221 (35%), Gaps = 27/221 (12%)

Query: 1206 SSEPEPTPGAAKPETPQAP----PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261
            SS P  +P    P   + P    P+ P R P R P    P+ + +     P     Q+  
Sbjct: 1043 SSSPRTSP-CQSPTISEGPVPSLPIRPSRAPSRTPG--PPSAQSSPIDAQPATPLPQKD- 1098

Query: 1262 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP-GKAAERPSHRKPASDEAP-------- 1312
                 P E     PP   AP   P P  R   P G  +  P+ ++  + ++P        
Sbjct: 1099 --PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNI 1156

Query: 1313 ------PGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDS 1366
                  P AG + P P       P +PPR    +    H +   S  +L       +S++
Sbjct: 1157 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA--SAGRLTPESQSKTSET 1214

Query: 1367 PSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL 1407
              G       + PQ  F   SS   P     + + P AAP+
Sbjct: 1215 SKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPM 1255


>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
           isoform b [Homo sapiens]
          Length = 893

 Score =  223 bits (568), Expect = 1e-57
 Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%)

Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576
           + +R+ E+ N +  R  +GTWNVNG           + L  WL              D +
Sbjct: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267

Query: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636
           P DI+ +GF+E+ +LS        +  ++ W   +++ +    +Y  +   +LVG+ L I
Sbjct: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326

Query: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696
           F R     +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A     + R
Sbjct: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386

Query: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749
           N+DYK+I  ++ F +        N+  H+ V W GD NYR+ +    EV   + ++D ++
Sbjct: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446

Query: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809
           LL+FDQL +Q++  K F DF+EG I F PTYKYD  +  +D+S KCR PAW DR+LW   
Sbjct: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503

Query: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869
                                   R T +   L Y    EL+ SDH+PV A+  + V+ V
Sbjct: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538

Query: 870 DVGARERVFQE 880
           D     +VF++
Sbjct: 539 DERRYRKVFED 549


>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
           isoform a [Homo sapiens]
          Length = 901

 Score =  223 bits (568), Expect = 1e-57
 Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%)

Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576
           + +R+ E+ N +  R  +GTWNVNG           + L  WL              D +
Sbjct: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267

Query: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636
           P DI+ +GF+E+ +LS        +  ++ W   +++ +    +Y  +   +LVG+ L I
Sbjct: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326

Query: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696
           F R     +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A     + R
Sbjct: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386

Query: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749
           N+DYK+I  ++ F +        N+  H+ V W GD NYR+ +    EV   + ++D ++
Sbjct: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446

Query: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809
           LL+FDQL +Q++  K F DF+EG I F PTYKYD  +  +D+S KCR PAW DR+LW   
Sbjct: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503

Query: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869
                                   R T +   L Y    EL+ SDH+PV A+  + V+ V
Sbjct: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538

Query: 870 DVGARERVFQE 880
           D     +VF++
Sbjct: 539 DERRYRKVFED 549


>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
           [Homo sapiens]
          Length = 913

 Score =  206 bits (525), Expect = 1e-52
 Identities = 133/423 (31%), Positives = 212/423 (50%), Gaps = 63/423 (14%)

Query: 494 VADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTA 553
           V+DK  +L      L    +   + +++ ++T  +  R   GT+NVNG  Q     LR  
Sbjct: 229 VSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNG--QSPKECLRL- 285

Query: 554 ELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQK 613
               WL +  Q              D++ VGF+E+ +LS        T  ++ W + + +
Sbjct: 286 ----WLSNGIQAP------------DVYCVGFQEL-DLSKEAFFFHDTPKEEEWFKAVSE 328

Query: 614 AISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQ 673
            +    +Y  +   +LVG+ L ++V+  H  +I +V  +TV TG+ G+ GNKG V IRFQ
Sbjct: 329 GLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQ 388

Query: 674 FHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCF--------PMGRNVFSHDYVFWCG 725
           FH+TS C + SHL A   + + RN+DYK+I  ++ F        P+   + +HD + W G
Sbjct: 389 FHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL--TISNHDVILWLG 446

Query: 726 DFNYRI-DLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDV 784
           D NYRI +L  E+V   ++ +D++ L  +DQL++Q ++  +F+ F EG + F PTYKYD 
Sbjct: 447 DLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDT 506

Query: 785 GSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQY 844
           GS  +DTS+KCR PAW DR+LW  K           N+                   L Y
Sbjct: 507 GSDDWDTSEKCRAPAWCDRILWKGK-----------NITQ-----------------LSY 538

Query: 845 YGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEK 904
                L+ SDH+PV ++ ++ V+ V+     +  +E+      LD     N+ S +L  K
Sbjct: 539 QSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVR---SLDKMENANIPSVSL-SK 594

Query: 905 NEF 907
            EF
Sbjct: 595 REF 597


>gi|190014578 suppressor of actin 1 [Homo sapiens]
          Length = 587

 Score =  190 bits (482), Expect = 1e-47
 Identities = 147/492 (29%), Positives = 244/492 (49%), Gaps = 51/492 (10%)

Query: 27  GRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCT 86
           G DD L  +  +       +K+V      +    +G LG + L +G    ++L+++T   
Sbjct: 26  GADDVLTIDRVSTEVTLAVKKDVPPSAVTR--PIFGILGTIHLVAG----NYLIVITKKI 79

Query: 87  SVGRIPDAEIYKITATDFYPLQE--------EAKEEERLIA-LKKILSSGVFYFSWPNDG 137
            VG      ++K T  D    ++        + ++ +  +A L  +L+   FYFS     
Sbjct: 80  KVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFS----- 134

Query: 138 SRFDLTVRTQKQGDDSSEW---------GNSFFWN-QLLHVPLRQHQVSCCDWLLKIICG 187
           + +DLT   Q+  + S E+            F WN  LL     Q +V    + L ++ G
Sbjct: 135 TTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVH--RFALPVLHG 192

Query: 188 VVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSS 247
            +T+ +   + K     L+SR SC R G R++ RG++ +GH +NFVETEQ+++ +   +S
Sbjct: 193 FITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKAS 252

Query: 248 FVQIRGSVPLFWEQ-PGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGS 306
           FVQ RGS+P+FW Q P L+     L     +  +   F RH       YG+QV++NL+  
Sbjct: 253 FVQTRGSIPVFWSQRPNLKY--KPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQ 310

Query: 307 RGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWE--DF 364
           +G E+ L + F  ++ +S  +G    I FDFH+  K  + ++L  LL    ++  E   F
Sbjct: 311 KGSEKPLEQTFATMV-SSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYF 369

Query: 365 DVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL----SSKPIV 420
            V + G+ V+   Q+G  R NC+DCLDRTN +QS +A   L  QL+ LG+          
Sbjct: 370 LVDSAGQVVAN--QEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQ 427

Query: 421 DRFVESFKAMWSLNGHSLSKVFTGSRALE-------GKAKVGKLKDGARSMSRTIQSNFF 473
           D F + +K  W+ N ++ +K + G+ AL+        +  +G + DG  SM R  ++NF 
Sbjct: 428 DEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFS 487

Query: 474 DGVKQEAIKLLL 485
           DG +Q++I L L
Sbjct: 488 DGFRQDSIDLFL 499


>gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens]
          Length = 1132

 Score =  179 bits (455), Expect = 1e-44
 Identities = 135/430 (31%), Positives = 211/430 (49%), Gaps = 70/430 (16%)

Query: 108 QEEAKEEERLIA--LKKILSSGVFYFSWPNDGSRFDLTVRTQKQG----DDSSEW---GN 158
           +E+ K E RL+   LK  + S  FY+S       +DLT   Q+Q     D    W    +
Sbjct: 153 KEKEKLERRLLEELLKMFMDSESFYYSLT-----YDLTNSVQRQSTGERDGRPLWQKVDD 207

Query: 159 SFFWNQLLHVPLRQHQVSCCD-WLLKIICGVVTIRTVYASHKQAK--------------- 202
            FFWN+ +   L +      D W++ +I G V I  +  ++ ++                
Sbjct: 208 RFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQEST 267

Query: 203 ----------ACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIR 252
                       L+SR S  R G R+  RGV+ +G+V+N+VETEQ+I++ +   SFVQ R
Sbjct: 268 CVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTR 327

Query: 253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEV 312
           GSVP+FW Q G +      RL R  +     F  H       Y +QV++NL+   G E++
Sbjct: 328 GSVPVFWSQVGYRYNPRP-RLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKI 386

Query: 313 LNRAFKK--LLWASCHAGDTPMINFDFHQFAKGGKLEKLETL------LRPQLKLHW-ED 363
           +  A+ K  LL+ + H      ++FDFH+  +G K E ++TL      +   +K  W ++
Sbjct: 387 IGDAYLKQVLLFNNSH---LTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDE 443

Query: 364 FDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL--SSKPIVD 421
             V  K        Q+G  R+NC+DCLDRTN VQ+ IA  V+  QLK LG+    +P+  
Sbjct: 444 AGVICK--------QEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPV 495

Query: 422 RFVESFKAMWSLNGHSLSKVFTGSRALEG-------KAKVGKLKDGARSMSRTIQSNFFD 474
           +    ++ MW+ NG S+S+ + G+ AL+G       +   G +KDG  S +R   + F D
Sbjct: 496 KCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKD 555

Query: 475 GVKQEAIKLL 484
             +Q  I L+
Sbjct: 556 AYRQAVIDLM 565


>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase,
           A [Homo sapiens]
          Length = 638

 Score =  179 bits (453), Expect = 2e-44
 Identities = 113/334 (33%), Positives = 167/334 (50%), Gaps = 35/334 (10%)

Query: 531 RIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVE 590
           RI + TWNV            TA   D +     L G     DDS  AD+ A+G +E+  
Sbjct: 56  RITVVTWNVG-----------TAMPPDDVTSLLHLGGG----DDSDGADMIAIGLQEVNS 100

Query: 591 LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650
           +    + +A  T++  W E    A+     ++L++S ++ GV L +F + YH+PF+RDV 
Sbjct: 101 MLNKRLKDALFTDQ--WSELFMDALG-PFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQ 157

Query: 651 IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEIT--QKLC 708
            D  +TG+GG  GNKG V +R        CF+  HL A   + ++R ++++ I   Q+  
Sbjct: 158 TDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQ 217

Query: 709 FPMGRNVFSHDYVFWCGDFNYRIDLTYEEVF--YFVKRQDWKKLLEFDQLQLQKSSGKIF 766
            P  + +  HD VFW GD N+RI+ +Y+  F  + +      +L E DQL + K++  I 
Sbjct: 218 GPGAQGILDHDLVFWFGDLNFRIE-SYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPIL 276

Query: 767 KDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSD 826
           K F EG +NF PT+K+DVG+  YDTS K R PAWTDR+L W+ K P              
Sbjct: 277 KGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRIL-WKVKAP-----------GGG 324

Query: 827 LDVDTKVRHTWSPGALQYYGRAELQASDHRPVLA 860
                +  H        Y    E   SDH+PV A
Sbjct: 325 PSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAA 358


>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
            sapiens]
          Length = 1188

 Score =  155 bits (393), Expect = 2e-37
 Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%)

Query: 450  GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507
            GK  + K KDG+     +        +K +    KL+++ +   E++  K  +  DS   
Sbjct: 322  GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 380

Query: 508  LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567
                ++L+ M  + SE      I I +GTWN+        N     ++T W L   Q   
Sbjct: 381  EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 433

Query: 568  ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627
              DS D   P DI+ +G +E               ++K W E L+ ++         T A
Sbjct: 434  RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 480

Query: 628  --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685
               L  + + +  +P H   I  +  D VKTG+    GNKGAVG+ F F+ TS  F+ SH
Sbjct: 481  IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 540

Query: 686  LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735
            LT+G  +   RN++Y  I + L   +G    S         ++FW GD NYR+DL     
Sbjct: 541  LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 598

Query: 736  EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790
            E +   +K+Q +  LL  DQL  ++   K+F  F E  I F PTY+++       AY   
Sbjct: 599  ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 658

Query: 791  --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848
              T  K   P+W DRVLW  K +P      +                        Y   +
Sbjct: 659  KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 693

Query: 849  ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906
            ++  SDH PV A  E  V    V           +  G +D+   +       TL+ K++
Sbjct: 694  DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 744

Query: 907  --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964
              F  +  +  +++            ++G+++V F ++   L  +  D   +  + + I 
Sbjct: 745  TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 804

Query: 965  PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019
             K+ D  +   E  I  R    ++  P+ +P  +   L  +F        S+G   E   
Sbjct: 805  IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 864

Query: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076
            D++    DE + P    S    D +      T+ APP    ++T +  +P Y        
Sbjct: 865  DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 915

Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131
                   VG F    P   L V     P Q P      +PP  + L   +  S  +    
Sbjct: 916  ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 962

Query: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191
              GQ  I    + LP    +    RT  S+P ++ +                  A     
Sbjct: 963  PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1004

Query: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245
            +E L    P   E       SS P+P      P   Q  P +PR+ PP  P   +P +  
Sbjct: 1005 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1054

Query: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299
                LSP       ++  T        E P      +  P P+ R+F    +AE      
Sbjct: 1055 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1098

Query: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347
               +   + P S +AP  A   + P       + PP     PP   KS PA  HLQ
Sbjct: 1099 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1153


>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
            sapiens]
          Length = 1189

 Score =  155 bits (393), Expect = 2e-37
 Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%)

Query: 450  GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507
            GK  + K KDG+     +        +K +    KL+++ +   E++  K  +  DS   
Sbjct: 323  GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 381

Query: 508  LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567
                ++L+ M  + SE      I I +GTWN+        N     ++T W L   Q   
Sbjct: 382  EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 434

Query: 568  ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627
              DS D   P DI+ +G +E               ++K W E L+ ++         T A
Sbjct: 435  RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 481

Query: 628  --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685
               L  + + +  +P H   I  +  D VKTG+    GNKGAVG+ F F+ TS  F+ SH
Sbjct: 482  IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 541

Query: 686  LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735
            LT+G  +   RN++Y  I + L   +G    S         ++FW GD NYR+DL     
Sbjct: 542  LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 599

Query: 736  EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790
            E +   +K+Q +  LL  DQL  ++   K+F  F E  I F PTY+++       AY   
Sbjct: 600  ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 659

Query: 791  --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848
              T  K   P+W DRVLW  K +P      +                        Y   +
Sbjct: 660  KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 694

Query: 849  ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906
            ++  SDH PV A  E  V    V           +  G +D+   +       TL+ K++
Sbjct: 695  DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 745

Query: 907  --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964
              F  +  +  +++            ++G+++V F ++   L  +  D   +  + + I 
Sbjct: 746  TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 805

Query: 965  PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019
             K+ D  +   E  I  R    ++  P+ +P  +   L  +F        S+G   E   
Sbjct: 806  IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 865

Query: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076
            D++    DE + P    S    D +      T+ APP    ++T +  +P Y        
Sbjct: 866  DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 916

Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131
                   VG F    P   L V     P Q P      +PP  + L   +  S  +    
Sbjct: 917  ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 963

Query: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191
              GQ  I    + LP    +    RT  S+P ++ +                  A     
Sbjct: 964  PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1005

Query: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245
            +E L    P   E       SS P+P      P   Q  P +PR+ PP  P   +P +  
Sbjct: 1006 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1055

Query: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299
                LSP       ++  T        E P      +  P P+ R+F    +AE      
Sbjct: 1056 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1099

Query: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347
               +   + P S +AP  A   + P       + PP     PP   KS PA  HLQ
Sbjct: 1100 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1154


>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens]
          Length = 1258

 Score =  153 bits (387), Expect = 1e-36
 Identities = 206/870 (23%), Positives = 326/870 (37%), Gaps = 175/870 (20%)

Query: 512  RILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDS 571
            ++L+ M  + S+      I + +GTWN+        +V     +T W   S  L    D 
Sbjct: 406  QLLQLMKNKHSKQDEPDMISVFIGTWNMG-------SVPPPKNVTSWFT-SKGLGKTLDE 457

Query: 572  QDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISR----SHRYILLTSA 627
               + P DI+  G +E            ++   + W + L+  +       +R I + S 
Sbjct: 458  VTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQS- 504

Query: 628  QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT 687
             L  + + + V+P H   I  V+  +VKTG+    GNKGAVG+ F F+ TSF F+  HLT
Sbjct: 505  -LWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLT 563

Query: 688  AGQSQVKERNEDYKEITQKLCFPMGR-NVFS----HDYVFWCGDFNYRIDLTYEEVFYFV 742
            +G  +   RN++Y +I + L     + N F       ++FW GD NYR+D+  +E+  ++
Sbjct: 564  SGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYI 623

Query: 743  KRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGS-------AAYDTSDKC 795
             R++++ LL  DQL L++   K+F  F E  I+F PTY+Y+ GS           T  + 
Sbjct: 624  SRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 683

Query: 796  RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
              P+W DR+LW  K +P      E +++ +                  Y    ++  SDH
Sbjct: 684  NVPSWCDRILW--KSYP------ETHIICN-----------------SYGCTDDIVTSDH 718

Query: 856  RPVLAIVEVEVQEVDVGAR------ERVFQEVSSFQGPLDAT----VVVNLQSPTLEE-K 904
             PV    EV V    +  +      ++ + E  S +  +         +   S  LEE K
Sbjct: 719  SPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYK 778

Query: 905  NEFPEDLRT----ELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960
              F  D ++      ++   S   +  ++      +    D H  L+V  +DG +  G  
Sbjct: 779  KSFENDAQSSDNINFLKVQWSSRQLPTLKPILAD-IEYLQDQHLLLTVKSMDGYESYGEC 837

Query: 961  V-----KIRPKTKDWLKGLR---EEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEG 1012
            V      I    + +L  L    EE    R SM    PT      E  +++ S+D +  G
Sbjct: 838  VVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAG 897

Query: 1013 DILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDA 1072
                        +   P VS         S  P  T  + P        +K  PT +  A
Sbjct: 898  -----------AKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPA 946

Query: 1073 DLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGT 1132
                               P R+        P   P+  P P G+     A+    +S  
Sbjct: 947  -------------------PPRAAPREEPLTPRLKPEGAPEPEGV-----AAPPPKNSFN 982

Query: 1133 HGQYSILQTA--RLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA 1190
            +  Y +L+    +LLP  P  P +A                +A + + AI       G  
Sbjct: 983  NPAYYVLEGVPHQLLPPEPPSPARA-------------PVPSATKNKVAITVPAPQLGHH 1029

Query: 1191 SEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRR--PPPRVPAIKKPTLRRTGK 1248
                     PR  E SS  E + G   P     PPL       PP +  +  P +R  G 
Sbjct: 1030 RH-------PRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGG 1082

Query: 1249 PLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE--------- 1299
              +              GPP      P     P +PP P P +   G+ A          
Sbjct: 1083 AEAR-------------GPP-----PPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVL 1124

Query: 1300 RPSHRKPASDEAP--PGAGASVPPPLEAPP 1327
            + +      D AP  P   A +P PLE  P
Sbjct: 1125 QMAKTLSEVDYAPAGPARSALLPGPLELQP 1154



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 43/164 (26%), Positives = 61/164 (37%), Gaps = 13/164 (7%)

Query: 1175 EAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPP-- 1232
            +A +  R   E R G+ + A +  +        EPE  P   +P  P  P   PR  P  
Sbjct: 901  KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAP--PRAAPREEPLT 958

Query: 1233 PRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP---KP 1289
            PR+     P       P  P+  F     +   G P   +  PP   +P   PVP   K 
Sbjct: 959  PRLKPEGAPEPEGVAAP-PPKNSFNNPAYYVLEGVPHQLL--PPEPPSPARAPVPSATKN 1015

Query: 1290 RTFQPGKAAERPSHRKPASDEAPPG---AGASVPPPLEAPPLVP 1330
            +      A +   HR P   E       +G ++PPP   PP +P
Sbjct: 1016 KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLP 1059


>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
          Length = 644

 Score =  139 bits (351), Expect = 2e-32
 Identities = 114/386 (29%), Positives = 174/386 (45%), Gaps = 82/386 (21%)

Query: 499 GMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDW 558
           G LL S ALL    + +   +R         + + + TWN+ G K+   +      L ++
Sbjct: 276 GSLLASGALLGADELARYFPDRN--------VALFVATWNMQGQKELPPS------LDEF 321

Query: 559 LLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRS 618
           LL +          +     D++ +G +E              ++++ W  +LQ+ +   
Sbjct: 322 LLPA----------EADYAQDLYVIGVQE------------GCSDRREWETRLQETLGP- 358

Query: 619 HRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTS 678
             Y+LL+SA    + + +F+R   + F  +V   TV T +  +   KGA+GI F F  TS
Sbjct: 359 -HYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTS 417

Query: 679 FCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNV--------------FSHDYVFWC 724
           F FI SH T+G  +V ER  DY    Q L  P  RNV                 D VFW 
Sbjct: 418 FLFITSHFTSGDGKVAERLLDYTRTVQALVLP--RNVPDTNPYRSSAADVTTRFDEVFWF 475

Query: 725 GDFNYRID---LTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK 781
           GDFN+R+       + +       D   LL+ DQL  +   G IFK F E  I+F P+YK
Sbjct: 476 GDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYK 535

Query: 782 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA 841
           +D+G   YD++ K RTP++TDRVL +R +H  D                  V ++  PG 
Sbjct: 536 FDIGKDTYDSTSKQRTPSYTDRVL-YRSRHKGD---------------ICPVSYSSCPG- 578

Query: 842 LQYYGRAELQASDHRPVLAIVEVEVQ 867
                   ++ SDHRPV  +  V+V+
Sbjct: 579 --------IKTSDHRPVYGLFRVKVR 596



 Score = 34.7 bits (78), Expect = 0.71
 Identities = 50/196 (25%), Positives = 73/196 (37%), Gaps = 25/196 (12%)

Query: 1091 SPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
            SP+ + S P  P    PP R  P       +   + ++S    G        R   G+ Q
Sbjct: 47   SPALACSTPATPSGEDPPARAAPIAPRPPARPRLERALSLDDKGW-----RRRRFRGS-Q 100

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLL-------EARGGASEEALSAVA---P 1200
            +  +AR G S      Q +   A     +  CL        ++RG  S E  S  +   P
Sbjct: 101  EDLEARNGTSPSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNP 160

Query: 1201 RDLEASSEPE--PTPGAAKPETPQAPPLLPRRPPPRVPA-IKKPTLRRTGKPLSPEEQFE 1257
                ASS P       A    +P+ P LLP RPPP +   I   +LR   K  S    ++
Sbjct: 161  LSGVASSSPNLPHRDAAVAGSSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYK 220

Query: 1258 QQT------VHFTIGP 1267
             +        H ++GP
Sbjct: 221  LRAQPLLVRAHSSLGP 236



 Score = 31.2 bits (69), Expect = 7.8
 Identities = 50/223 (22%), Positives = 78/223 (34%), Gaps = 32/223 (14%)

Query: 1284 PPVPKPRTFQPGKAAERPSHRKPASDEAP----PGAGASVP-------PPLEAPPLVPKV 1332
            P  P+ RT Q       P+ R  +  +AP    P    S P       PP  A P+ P+ 
Sbjct: 15   PQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPPARAAPIAPRP 74

Query: 1333 PPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSP 1392
            P R +     A  L       +  +G +    ++ +G  P+ G+V  +G      S + P
Sbjct: 75   PARPR--LERALSLDDKGWRRRRFRG-SQEDLEARNGTSPSRGSVQSEGPGAPAHSCSPP 131

Query: 1393 DSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDS-GTRSPKRDPIDP 1451
                +    P++  +L   +                  S   +PL    + SP     D 
Sbjct: 132  CLSTSLQEIPKSRGVLSSERGS---------------PSSGGNPLSGVASSSPNLPHRDA 176

Query: 1452 VSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLA 1494
              AG+S     L P      L   + I+    RTA +V   LA
Sbjct: 177  AVAGSSPRLPSLLPPRPPPALS--LDIASDSLRTANKVDSDLA 217


>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
           sapiens]
          Length = 448

 Score =  129 bits (323), Expect = 3e-29
 Identities = 102/357 (28%), Positives = 165/357 (46%), Gaps = 40/357 (11%)

Query: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWL-LDSPQLSGATDSQDDS 575
           M+ R+      +R+ I + TWNV       ++     +L+D L L++  L+         
Sbjct: 1   MSSRKLSGPKGRRLSIHVVTWNV-------ASAAPPLDLSDLLQLNNRNLN--------- 44

Query: 576 SPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLY 635
              DI+ +G +E+       + +A+  +   W   L   +S    +I ++  ++ G+ L 
Sbjct: 45  --LDIYVIGLQELNSGIISLLSDAAFNDS--WSSFLMDVLSPLS-FIKVSHVRMQGILLL 99

Query: 636 IFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKE 695
           +F +  H+P+I+ ++  +  TG+ G  GNKG V I  + +      I  HL    S   +
Sbjct: 100 VFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQ 159

Query: 696 RNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTYEEVFYFVKRQDWKKL 750
           R E +  I + + C   GR   N+  HD + W GD N+RI D     V   +K + +  L
Sbjct: 160 RLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGL 217

Query: 751 LEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKK 810
            E DQL + K    + ++F EG + F PTYK+D  S  YDTS+K R PAWTDR+LW  K+
Sbjct: 218 WEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKR 277

Query: 811 HPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ 867
            P    AG         D        +S     Y        SDH+PV    ++E++
Sbjct: 278 QP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELK 323


>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  123 bits (308), Expect = 2e-27
 Identities = 81/252 (32%), Positives = 123/252 (48%), Gaps = 18/252 (7%)

Query: 621 YILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680
           +I ++  ++ G+ L +F +  H+P+I+ ++  +  TG+ G  GNKG V I  + +     
Sbjct: 9   FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68

Query: 681 FICSHLTAGQSQVKERNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTY 735
            I  HL    S   +R E +  I + + C   GR   N+  HD + W GD N+RI D   
Sbjct: 69  IINCHLPPHISNNYQRLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGL 126

Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKC 795
             V   +K + +  L E DQL + K    + ++F EG + F PTYK+D  S  YDTS+K 
Sbjct: 127 HFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKK 186

Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
           R PAWTDR+LW  K+ P    AG         D        +S     Y        SDH
Sbjct: 187 RKPAWTDRILWRLKRQP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDH 235

Query: 856 RPVLAIVEVEVQ 867
           +PV    ++E++
Sbjct: 236 KPVSGTFDLELK 247


>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  123 bits (308), Expect = 2e-27
 Identities = 81/252 (32%), Positives = 123/252 (48%), Gaps = 18/252 (7%)

Query: 621 YILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680
           +I ++  ++ G+ L +F +  H+P+I+ ++  +  TG+ G  GNKG V I  + +     
Sbjct: 9   FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68

Query: 681 FICSHLTAGQSQVKERNEDYKEITQ-KLCFPMGR---NVFSHDYVFWCGDFNYRI-DLTY 735
            I  HL    S   +R E +  I + + C   GR   N+  HD + W GD N+RI D   
Sbjct: 69  IINCHLPPHISNNYQRLEHFDRILEMQNC--EGRDIPNILDHDLIIWFGDMNFRIEDFGL 126

Query: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKC 795
             V   +K + +  L E DQL + K    + ++F EG + F PTYK+D  S  YDTS+K 
Sbjct: 127 HFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKK 186

Query: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
           R PAWTDR+LW  K+ P    AG         D        +S     Y        SDH
Sbjct: 187 RKPAWTDRILWRLKRQP---CAGP--------DTPIPPASHFSLSLRGYSSHMTYGISDH 235

Query: 856 RPVLAIVEVEVQ 867
           +PV    ++E++
Sbjct: 236 KPVSGTFDLELK 247


>gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo
           sapiens]
          Length = 907

 Score =  105 bits (262), Expect = 3e-22
 Identities = 138/531 (25%), Positives = 218/531 (41%), Gaps = 112/531 (21%)

Query: 51  KGQYG--KLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQ 108
           KG  G  +   A+G +G +R   G     ++VL+T    +  I    IYK+  T+   + 
Sbjct: 81  KGSSGLFRAVSAFGVVGFVRFLEG----YYIVLITKRRKMADIGGHAIYKVEDTNMIYIP 136

Query: 109 EEA------KEEERLIALKKILSSGVFYFSWPNDGS---RFDLTV-----------RTQK 148
            ++       E   L   + +  S  FYFS+  D S   +++LTV            TQ 
Sbjct: 137 NDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQN 196

Query: 149 QGDD--------------------SSEWGNSFFWN-QLLHV-PLRQHQVSCCDWLLKIIC 186
           + +                      SE    + WN +LL +     H+    DWLL II 
Sbjct: 197 RQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHR----DWLLYIIH 252

Query: 187 GVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQ-------MI 239
           G      +    +     L++R S +  GTRF  RG N +G V+N VETEQ       M 
Sbjct: 253 GFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMS 312

Query: 240 YMDDGVSSFVQIRGSVPLFWEQP-GLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQ 298
           +     SS+VQ+RGSVPL+W Q     +    + L +  +  A     H   + +++G  
Sbjct: 313 FTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQA-DPFAHVAALHFDQMFQRFGSP 371

Query: 299 VVV-NLLGSRGGEEVLNRAFKKLLWASCHAGD-------TPMINFDFHQFAKGGKLEKLE 350
           +++ NL+  R   +      ++L+ A  +             I +D  ++ K      L+
Sbjct: 372 IIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLD 431

Query: 351 ------------------------TLLRPQLKLHWEDFDVFTKGENVSP--RFQKGTLRM 384
                                   ++LRP  K  W +      G  V P  R Q G LR 
Sbjct: 432 RLNVIAESVVKKTGFFVNRPDSYCSILRPDEK--WNEL-----GGCVIPTGRLQTGILRT 484

Query: 385 NCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD---RFVESFKAMWSLNGHSLSKV 441
           NC+DCLDRTNT Q  +    L  QL +LGL  KP +      V  F+ ++  +G +LS  
Sbjct: 485 NCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQ 544

Query: 442 FTGSRALEGKAKVGKL-------KDGARSMSRTIQSNFFDGVKQEAIKLLL 485
           + GS+ +       K+       KD  +++SR   + F D  +Q++I L L
Sbjct: 545 YGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFL 595


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 102/429 (23%), Positives = 146/429 (34%), Gaps = 57/429 (13%)

Query: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQY 1136
            L  + + V  +    PS  L  P  P PP PP  PPPP  L   +SA  A  ++    +Y
Sbjct: 609  LSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL-PSQSAPSAGSAAPMFVKY 667

Query: 1137 SI---LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE 1193
            S    LQ A    GA  +PP      S+    + +   N               G A  +
Sbjct: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQ 727

Query: 1194 ALSAVAPRDLEASSEPEP-------------TPGAAKPETPQAPPLLPRRPPPRVPAIKK 1240
               A     L   S P P              P    P  P   PL P+ PP  +  I  
Sbjct: 728  LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPA 787

Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKP-------RTF- 1292
            PT  +T  P+  +      T        + +  A  +  +P  PPVP P       ++F 
Sbjct: 788  PTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFC 847

Query: 1293 ---QPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVL 1349
                P   +  PS  K  + + PP      PP +E+ PL P       +S PA       
Sbjct: 848  AKPPPSPLSPVPSVVKQIASQFPP---PPTPPAMESQPLKPVPANVAPQSPPAVKAKPKW 904

Query: 1350 QSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLST---------SSATSPDSDGTKAM 1400
            Q +S     +   S D P   PP +  VFP                +++ +PD  G+   
Sbjct: 905  QPSS-----IPVPSPDFPP-PPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK 958

Query: 1401 KPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPI----DPVSAGA 1456
            K       G  + P       P    N+ +  SS       + P  D +     P +   
Sbjct: 959  KTSKTSSPGGKKPP-------PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESG 1011

Query: 1457 SAAKAELPP 1465
            S +K  LPP
Sbjct: 1012 SPSKETLPP 1020



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 66/267 (24%), Positives = 97/267 (36%), Gaps = 36/267 (13%)

Query: 1086 EFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLL 1145
            +F    P  SL  P  P PP P   PPPP       +AS     SG+ G+ +   ++   
Sbjct: 915  DFPPPPPESSLVFP--PPPPSPVPAPPPPP----PPTASPTPDKSGSPGKKTSKTSS--- 965

Query: 1146 PGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEA 1205
            PG  + PP        P     IK+++  E         E +  + +  +S   P     
Sbjct: 966  PGGKKPPPT-------PQRNSSIKSSSGAEHP-------EPKRPSVDSLVSKFTPPAESG 1011

Query: 1206 SSEPEPTPGAAKPETPQAPPL----LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261
            S   E  P  A P  P    L    LP        + K P L   GK    E        
Sbjct: 1012 SPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDS 1071

Query: 1262 HFTIGPPETSVEAPPVV--------TAPRVPPV-PKPRTFQPGKAAERPSHRKPASDEAP 1312
             F   PPET +  PP+         T+P+V  V P+P+ +      + P   +P  +++ 
Sbjct: 1072 DFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDST 1131

Query: 1313 PGAGASVPPPLEAPPLVPKVPPRRKKS 1339
                A +        +VP+VP   K S
Sbjct: 1132 RLTQAEISEQPTMATVVPQVPTSPKSS 1158



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 70/341 (20%), Positives = 104/341 (30%), Gaps = 77/341 (22%)

Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRP 1104
            P  T  APP+ +P +   K+ P +                          +  +P  P P
Sbjct: 796  PVVTQAAPPTPTPPVPPAKKQPAFP-------------------------ASYIP--PSP 828

Query: 1105 PQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYN 1164
            P PP   PPPT    +   +    S  +     + Q A   P  P  P       S+P  
Sbjct: 829  PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP-- 882

Query: 1165 VKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPET---- 1220
            +K +    A ++  A++                 A    + SS P P+P    P      
Sbjct: 883  LKPVPANVAPQSPPAVK-----------------AKPKWQPSSIPVPSPDFPPPPPESSL 925

Query: 1221 --PQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVV 1278
              P  PP     PPP  P    PT  ++G P                G   +   +P   
Sbjct: 926  VFPPPPPSPVPAPPPPPPPTASPTPDKSGSP----------------GKKTSKTSSP--- 966

Query: 1279 TAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKK 1338
               + PP P P+     K++    H +P             PP     P    +PP    
Sbjct: 967  -GGKKPP-PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP 1024

Query: 1339 SAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFP 1379
              P   +L  +     L QG     +   SG    +   FP
Sbjct: 1025 PKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFP 1065



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 72/334 (21%), Positives = 108/334 (32%), Gaps = 72/334 (21%)

Query: 1042 SDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNR 1101
            S VP P    PP+ SP   K                             SP +  S  + 
Sbjct: 933  SPVPAPPPPPPPTASPTPDKS---------------------------GSPGKKTSKTSS 965

Query: 1102 PRPPQPPQRPPPPTGLMVKKSAS-----------DASISSGTHGQYSILQTARLLPGAPQ 1150
            P   +PP  P P     +K S+            D+ +S  T    S   +   LP  P 
Sbjct: 966  PGGKKPP--PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLP-PPA 1022

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210
             PPK         N+  +       A+A +   L  RG  S        P     S  P 
Sbjct: 1023 APPKPGKLNLSGVNLPGVLQQGCVSAKAPV---LSGRGKDSVVEF----PSPPSDSDFPP 1075

Query: 1211 PTPGAAKPETP-QAPPLLPRRPPPRVPAI-------KKPTLRRTGKPLSPEEQFEQQTVH 1262
            P P    P  P + P +      P+V  +        K ++++   P  P+     +   
Sbjct: 1076 PPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQ 1135

Query: 1263 FTIGPPETSVEAPPVVT-APRVPPVPKPR-TFQPGKAAE--RPSHRKPASDEAPPGAGAS 1318
              I       E P + T  P+VP  PK   + QPG  A+  R   RK  +      +  S
Sbjct: 1136 AEIS------EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMS 1189

Query: 1319 VPPP------LEAPPLVPKVPPRRKKSAPAAFHL 1346
               P      +  PP  P++   ++K+     H+
Sbjct: 1190 RAEPTATMDDMALPPPPPELLSDQQKAGYGGSHI 1223


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 70/258 (27%), Positives = 98/258 (37%), Gaps = 37/258 (14%)

Query: 1091 SPSRSL--SVPNRPRPPQPPQRP----PPPTGLMVKKSASDASISSGTHGQYSILQTARL 1144
            SP +S+  SVP R   PQPP  P    PPP+G      A +A+ S G            L
Sbjct: 1308 SPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEG------------L 1355

Query: 1145 LPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLE 1204
              G P   P  R       N++ + + ++ E ++       A+    +E++S+     + 
Sbjct: 1356 GLGCPS--PCKRLDEELKRNLETLPSFSSDEEDSV------AKNRDLQESISSA----IS 1403

Query: 1205 ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
            A  +P P  G     TP  PPL P    P  P +  P L       +PE    ++    T
Sbjct: 1404 ALDDP-PLAGPKDTSTPDGPPLAPAAAVPGPPPL--PGLPSANSNGTPEPPLLEEKPPPT 1460

Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLE 1324
              P  T    PP    P  P +P P    P   A  PS   P     PP      PPP  
Sbjct: 1461 PPPAPTPQPQPPPPPPPPQPALPSP----PPLVAPTPSSPPPPPLPPPPPPAMPSPPPPP 1516

Query: 1325 APPLVPKVPPRRKKSAPA 1342
             P   P   P  + +AP+
Sbjct: 1517 PPAAAPLAAPPEEPAAPS 1534



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 85/357 (23%), Positives = 117/357 (32%), Gaps = 67/357 (18%)

Query: 1029 PGVSDSELGGDDLSDVPGPTA-LAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEF 1087
            PGV      G  LS V      LAPP           +    D ++L+         G  
Sbjct: 578  PGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLA-----GPGGPP 632

Query: 1088 RHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPG 1147
              R+      + +  + P PP R     GL+ +  A+DAS   G  G            G
Sbjct: 633  AERTEDEEFLIQHLLQAPSPP-RTSGADGLVGEDGAADASKGLGGSGGAG---------G 682

Query: 1148 APQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLL------------EARGGASEEAL 1195
             P  P +      + Y+++ +  T+A   E A   L               RGG + E L
Sbjct: 683  PPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAALELGLGRLKEKKKGPERGGETPEGL 742

Query: 1196 SA------VAPRDLEA---SSEPEPTPGAAKPET-----------PQAPPLLPRRPPPRV 1235
            +          ++L A    S P P P A   +            P  P +LP  PP  +
Sbjct: 743  ATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLL 802

Query: 1236 PAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP- 1294
            P++            SP     +  VH     P T   AP     P  PP P P   +  
Sbjct: 803  PSV-------LSHAPSPSPSASKVGVHLL--EPATRDGAPQPPPPPPPPPPPMPLQLEAH 853

Query: 1295 ----GKAAERPSHR-KPASDEAPPGAGASVPPPLEAPPLVP----KVPPRRKKSAPA 1342
                G     PS R +P     PPGA   +   LE  P  P      PP  +   PA
Sbjct: 854  LRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPA 910



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 84/336 (25%), Positives = 107/336 (31%), Gaps = 93/336 (27%)

Query: 1035 ELGGDDLSDV--PGPTALAP------PSKSPALTKKKQH---PTYKDDADLVELKRELEA 1083
            E GG DL  V  P P  L P      PS SP+ +K   H   P  +D A           
Sbjct: 784  EAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGA----------- 832

Query: 1084 VGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAR 1143
                              P+PP PP  PPPP  L +     +A + S  HG      + R
Sbjct: 833  ------------------PQPPPPPPPPPPPMPLQL-----EAHLRS--HGLEPAAPSPR 867

Query: 1144 LLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL 1203
            L P     PP A                  QE   A+  L  A G       + V P   
Sbjct: 868  LRPEESLDPPGA-----------------MQELLGALEPLPPAPGD------TGVGP--- 901

Query: 1204 EASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP--EEQFEQQTV 1261
              +SE +   GA +  +PQ     PR  P          L+   +   P  EE F     
Sbjct: 902  -PNSEGKDPAGAYRSPSPQGTK-APRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAA 959

Query: 1262 --HFTIGPPETSVEAPPVVTAPRVPPVPKP-RTFQPGKAA-------------ERPSHRK 1305
              +   GPPE   +       P  PP   P   + PG+A+              +P    
Sbjct: 960  DDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELP 1019

Query: 1306 PASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341
               +  P G   S P     PP  P  PP    S P
Sbjct: 1020 STVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEP 1055



 Score = 36.6 bits (83), Expect = 0.19
 Identities = 67/270 (24%), Positives = 95/270 (35%), Gaps = 60/270 (22%)

Query: 1071 DADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASI-- 1128
            DA ++ L   LE+ G     S S  LS    P   Q     P PT L +  +   +S   
Sbjct: 85   DASVMNLISALESRGPQPGPSASSLLSQFRSPSW-QTAMHTPGPTELFISGALPGSSTFP 143

Query: 1129 SSGTHGQYSI----------LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEA 1178
            SS     Y            + ++  L   P  PP    G+  P++V  +K + A    +
Sbjct: 144  SSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPA--NGLLSPHDVLHLKPSQAPTVPS 201

Query: 1179 AIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAI 1238
            ++     A GG        + P  L  +  P   PG      P  PP     PPPR    
Sbjct: 202  SLGFERLAGGGV-------LGPAGLGPAQTPPYRPG------PPDPP-----PPPRHLPT 243

Query: 1239 KKPTLRRTGKPLSPEEQFEQQTVHFT---IGPPETSVEAPPVVTAPRVPPVPKPRTFQPG 1295
            +   L  +    +  EQ   Q  +F+    GPP      PP    PR   V K       
Sbjct: 244  QFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPP------PPERALPRQDTVIK------- 290

Query: 1296 KAAERPSHRKPASDEAPPGAGASVPPPLEA 1325
                   +++PAS + PP      PPP  A
Sbjct: 291  ------HYQRPASAQPPP-----PPPPAHA 309



 Score = 35.4 bits (80), Expect = 0.42
 Identities = 30/112 (26%), Positives = 46/112 (41%), Gaps = 11/112 (9%)

Query: 1231 PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRV-PPVPKP 1289
            PPP+ PA          KP +PE+   ++    T   PET++  PP    P +  PV K 
Sbjct: 1692 PPPKAPAPPP-------KPETPEKTTSEKPPEQT---PETAMPEPPAPEKPSLLRPVEKE 1741

Query: 1290 RTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341
            +  +     ERP   + A+         S+     A   +PK  P + K+ P
Sbjct: 1742 KEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEP 1793



 Score = 31.2 bits (69), Expect = 7.8
 Identities = 28/120 (23%), Positives = 43/120 (35%), Gaps = 2/120 (1%)

Query: 1099 PNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTG 1158
            P  P PP PP+  P    L+   SA+ A+    +   Y+    A   P   +  P+  T 
Sbjct: 229  PGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTV 288

Query: 1159 ISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKP 1218
            I         +         A++  L    G S  ++   A          EP+PGA +P
Sbjct: 289  IKHYQRPASAQPPPPPPPAHALQHYLSC--GGSYPSMGHRANLACSPLGGGEPSPGAGEP 346


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)

Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
            P PT    P+    K PA T  K  PT  K+ A     K       E    +P      P
Sbjct: 270  PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 327

Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
              P+ P P  + P PT        +    +  T  + +        P  P++P    T  
Sbjct: 328  TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 379

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
              P   K+   T  + A    +   E     ++ A +         + EP PT P    P
Sbjct: 380  PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436

Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
             TP+ P P  P+ P P  P    PT  +   P +P+E             P+      P 
Sbjct: 437  TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 496

Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
              AP  P  P P T +   A   P    P + E  AP    A+ P  P E  P  PK P 
Sbjct: 497  KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 555

Query: 1335 RRKKSAPA 1342
                  PA
Sbjct: 556  PTTPKEPA 563



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)

Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
            P PT +  AP + K PA T  K  PT   +      K       +       +  +P+ +
Sbjct: 232  PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 291

Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
             S P  P+ P P  P++P P T    + + +     + T  +     T    P  P++P 
Sbjct: 292  KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 348

Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
             A T   KP      +       E A     E      +E            + EP PT 
Sbjct: 349  -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 407

Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
              + P TP+ P         P  P+ P P  P    PT  +   P +P+E     T    
Sbjct: 408  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467

Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
               P+      P  TAP  P    P T +      P K A   P    P + E P     
Sbjct: 468  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 527

Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
              P P     A P  PK P       PA
Sbjct: 528  EEPAPTTPKAAAPNTPKEPAPTTPKEPA 555



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)

Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
            P PT   P   +P  TKK    T K+ A     +       +    +P + + + P +P 
Sbjct: 450  PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 507

Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
            P  P    P  P  PT    ++ A  +  + +  T  + +        P  P++P     
Sbjct: 508  PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 567

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
              + P   K    T  +E           +    E A +           +P PT P   
Sbjct: 568  KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623

Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
             P TP+ P P  P+ P P  P    PT  +   P +P++   ++    T  GP  T+ + 
Sbjct: 624  APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 683

Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
            P    P  TAP  P  P P T         P    P + E PP   +  S P   + P  
Sbjct: 684  PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 734

Query: 1329 VPKVP 1333
            + K P
Sbjct: 735  IHKSP 739



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)

Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
            +L+ P  P P  P +     P  PT   +K + +     + T        T +  P  P+
Sbjct: 209  ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 260

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
            +P    T    P   K+   T  +E       +     +     + +  +   P++   +
Sbjct: 261  EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 320

Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
            +  EPTP   K   P T +  P  P+ P P  P    PT  +   P +P+E     T   
Sbjct: 321  TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 380

Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
                        T   P T+ E  P  T  AP  P  P P T +   A   P    P + 
Sbjct: 381  SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 439

Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
            + P     +   P E  P  PK   P   KK AP
Sbjct: 440  KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 468



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 67/264 (25%), Positives = 98/264 (37%), Gaps = 33/264 (12%)

Query: 1091 SPSRSLSVPNRPRPPQPPQR-PPPPTGLMVKKSAS-DASISSGTHGQYSILQTARLLPGA 1148
            SP  + + P  PRP  PP       T L V K  + +   ++ T+ Q S         G 
Sbjct: 115  SPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS-------TDGK 167

Query: 1149 PQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA--SEEALSAVAPRDLEAS 1206
             +      T   +  + K +  T+   A+   +     +G A  + +  +   P++  ++
Sbjct: 168  EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST 227

Query: 1207 SEPEPTPGAAK--PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
            +  EPTP   K  P TP+ P     +  P  P    PT  +   P +P+E          
Sbjct: 228  TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP--------- 278

Query: 1265 IGPPETSVEAPPVVT--APRVPPVPKPRTFQPGK-AAERPSHRKPASDEAPPGAGASVPP 1321
               P T+ E  P  T  AP  P  P P T  P K A   P    P + + P       P 
Sbjct: 279  --APTTTKEPAPTTTKSAPTTPKEPAPTT--PKKPAPTTPKEPAPTTPKEPTPTTPKEPA 334

Query: 1322 PL--EAPPLVPK--VPPRRKKSAP 1341
            P   E  P  PK   P   KK AP
Sbjct: 335  PTTKEPAPTTPKEPAPTAPKKPAP 358



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 43/260 (16%)

Query: 1105 PQPPQRPPPPTGLM---VKKSASDASISSGTHGQYSI---LQTARLLPGAPQQPPKARTG 1158
            P+PP      +GL     K +  D S +   H + S    + TA+ +   P  PP + T 
Sbjct: 80   PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNKVSTSPKITTAKPINPRPSLPPNSDTS 137

Query: 1159 ------ISKPYNV--KQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSE-- 1208
                  ++K   V  K+  TTN Q +         A+   S E  SA   +DL  +S+  
Sbjct: 138  KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA---KDLAPTSKVL 194

Query: 1209 PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
             +PTP   K ET    P L  P+ P P  P   K     T K  +P           TI 
Sbjct: 195  AKPTP---KAETTTKGPALTTPKEPTPTTP---KEPASTTPKEPTPT----------TIK 238

Query: 1267 PPETSVEAPPVVTAPRVPPVPK----PRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322
               T+ + P   T    P  PK      T +P     +        + AP    ++   P
Sbjct: 239  SAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 298

Query: 1323 LEAPPLVPKVPPRRKKSAPA 1342
             E  P  PK P       PA
Sbjct: 299  KEPAPTTPKKPAPTTPKEPA 318


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)

Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
            P PT    P+    K PA T  K  PT  K+ A     K       E    +P      P
Sbjct: 311  PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 368

Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
              P+ P P  + P PT        +    +  T  + +        P  P++P    T  
Sbjct: 369  TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 420

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
              P   K+   T  + A    +   E     ++ A +         + EP PT P    P
Sbjct: 421  PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477

Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
             TP+ P P  P+ P P  P    PT  +   P +P+E             P+      P 
Sbjct: 478  TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 537

Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
              AP  P  P P T +   A   P    P + E  AP    A+ P  P E  P  PK P 
Sbjct: 538  KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 596

Query: 1335 RRKKSAPA 1342
                  PA
Sbjct: 597  PTTPKEPA 604



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)

Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
            P PT +  AP + K PA T  K  PT   +      K       +       +  +P+ +
Sbjct: 273  PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 332

Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
             S P  P+ P P  P++P P T    + + +     + T  +     T    P  P++P 
Sbjct: 333  KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 389

Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
             A T   KP      +       E A     E      +E            + EP PT 
Sbjct: 390  -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 448

Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
              + P TP+ P         P  P+ P P  P    PT  +   P +P+E     T    
Sbjct: 449  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508

Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
               P+      P  TAP  P    P T +      P K A   P    P + E P     
Sbjct: 509  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 568

Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
              P P     A P  PK P       PA
Sbjct: 569  EEPAPTTPKAAAPNTPKEPAPTTPKEPA 596



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)

Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
            P PT   P   +P  TKK    T K+ A     +       +    +P + + + P +P 
Sbjct: 491  PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 548

Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
            P  P    P  P  PT    ++ A  +  + +  T  + +        P  P++P     
Sbjct: 549  PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 608

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
              + P   K    T  +E           +    E A +           +P PT P   
Sbjct: 609  KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664

Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
             P TP+ P P  P+ P P  P    PT  +   P +P++   ++    T  GP  T+ + 
Sbjct: 665  APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 724

Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
            P    P  TAP  P  P P T         P    P + E PP   +  S P   + P  
Sbjct: 725  PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 775

Query: 1329 VPKVP 1333
            + K P
Sbjct: 776  IHKSP 780



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)

Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
            +L+ P  P P  P +     P  PT   +K + +     + T        T +  P  P+
Sbjct: 250  ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 301

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
            +P    T    P   K+   T  +E       +     +     + +  +   P++   +
Sbjct: 302  EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 361

Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
            +  EPTP   K   P T +  P  P+ P P  P    PT  +   P +P+E     T   
Sbjct: 362  TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 421

Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
                        T   P T+ E  P  T  AP  P  P P T +   A   P    P + 
Sbjct: 422  SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 480

Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
            + P     +   P E  P  PK   P   KK AP
Sbjct: 481  KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 509



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 67/264 (25%), Positives = 98/264 (37%), Gaps = 33/264 (12%)

Query: 1091 SPSRSLSVPNRPRPPQPPQR-PPPPTGLMVKKSAS-DASISSGTHGQYSILQTARLLPGA 1148
            SP  + + P  PRP  PP       T L V K  + +   ++ T+ Q S         G 
Sbjct: 156  SPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTS-------TDGK 208

Query: 1149 PQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA--SEEALSAVAPRDLEAS 1206
             +      T   +  + K +  T+   A+   +     +G A  + +  +   P++  ++
Sbjct: 209  EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST 268

Query: 1207 SEPEPTPGAAK--PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
            +  EPTP   K  P TP+ P     +  P  P    PT  +   P +P+E          
Sbjct: 269  TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP--------- 319

Query: 1265 IGPPETSVEAPPVVT--APRVPPVPKPRTFQPGK-AAERPSHRKPASDEAPPGAGASVPP 1321
               P T+ E  P  T  AP  P  P P T  P K A   P    P + + P       P 
Sbjct: 320  --APTTTKEPAPTTTKSAPTTPKEPAPTT--PKKPAPTTPKEPAPTTPKEPTPTTPKEPA 375

Query: 1322 PL--EAPPLVPK--VPPRRKKSAP 1341
            P   E  P  PK   P   KK AP
Sbjct: 376  PTTKEPAPTTPKEPAPTAPKKPAP 399



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 43/260 (16%)

Query: 1105 PQPPQRPPPPTGLM---VKKSASDASISSGTHGQYSI---LQTARLLPGAPQQPPKARTG 1158
            P+PP      +GL     K +  D S +   H + S    + TA+ +   P  PP + T 
Sbjct: 121  PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNKVSTSPKITTAKPINPRPSLPPNSDTS 178

Query: 1159 ------ISKPYNV--KQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSE-- 1208
                  ++K   V  K+  TTN Q +         A+   S E  SA   +DL  +S+  
Sbjct: 179  KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA---KDLAPTSKVL 235

Query: 1209 PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
             +PTP   K ET    P L  P+ P P  P   K     T K  +P           TI 
Sbjct: 236  AKPTP---KAETTTKGPALTTPKEPTPTTP---KEPASTTPKEPTPT----------TIK 279

Query: 1267 PPETSVEAPPVVTAPRVPPVPK----PRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322
               T+ + P   T    P  PK      T +P     +        + AP    ++   P
Sbjct: 280  SAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 339

Query: 1323 LEAPPLVPKVPPRRKKSAPA 1342
             E  P  PK P       PA
Sbjct: 340  KEPAPTTPKKPAPTTPKEPA 359


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)

Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
            P PT    P+    K PA T  K  PT  K+ A     K       E    +P      P
Sbjct: 363  PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 420

Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
              P+ P P  + P PT        +    +  T  + +        P  P++P    T  
Sbjct: 421  TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 472

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
              P   K+   T  + A    +   E     ++ A +         + EP PT P    P
Sbjct: 473  PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529

Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
             TP+ P P  P+ P P  P    PT  +   P +P+E             P+      P 
Sbjct: 530  TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 589

Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
              AP  P  P P T +   A   P    P + E  AP    A+ P  P E  P  PK P 
Sbjct: 590  KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 648

Query: 1335 RRKKSAPA 1342
                  PA
Sbjct: 649  PTTPKEPA 656



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)

Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
            P PT +  AP + K PA T  K  PT   +      K       +       +  +P+ +
Sbjct: 325  PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 384

Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
             S P  P+ P P  P++P P T    + + +     + T  +     T    P  P++P 
Sbjct: 385  KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 441

Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
             A T   KP      +       E A     E      +E            + EP PT 
Sbjct: 442  -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 500

Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
              + P TP+ P         P  P+ P P  P    PT  +   P +P+E     T    
Sbjct: 501  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560

Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
               P+      P  TAP  P    P T +      P K A   P    P + E P     
Sbjct: 561  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 620

Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
              P P     A P  PK P       PA
Sbjct: 621  EEPAPTTPKAAAPNTPKEPAPTTPKEPA 648



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)

Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
            P PT   P   +P  TKK    T K+ A     +       +    +P + + + P +P 
Sbjct: 543  PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 600

Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
            P  P    P  P  PT    ++ A  +  + +  T  + +        P  P++P     
Sbjct: 601  PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 660

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
              + P   K    T  +E           +    E A +           +P PT P   
Sbjct: 661  KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716

Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
             P TP+ P P  P+ P P  P    PT  +   P +P++   ++    T  GP  T+ + 
Sbjct: 717  APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 776

Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
            P    P  TAP  P  P P T         P    P + E PP   +  S P   + P  
Sbjct: 777  PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 827

Query: 1329 VPKVP 1333
            + K P
Sbjct: 828  IHKSP 832



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)

Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
            +L+ P  P P  P +     P  PT   +K + +     + T        T +  P  P+
Sbjct: 302  ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 353

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
            +P    T    P   K+   T  +E       +     +     + +  +   P++   +
Sbjct: 354  EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 413

Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
            +  EPTP   K   P T +  P  P+ P P  P    PT  +   P +P+E     T   
Sbjct: 414  TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 473

Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
                        T   P T+ E  P  T  AP  P  P P T +   A   P    P + 
Sbjct: 474  SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 532

Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
            + P     +   P E  P  PK   P   KK AP
Sbjct: 533  KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 561



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 72/286 (25%), Positives = 104/286 (36%), Gaps = 47/286 (16%)

Query: 1079 RELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM---VKKSASDASISSGTHGQ 1135
            REL+   + +    +R+   P     P+PP      +GL     K +  D S +   H +
Sbjct: 151  RELQKKLKVKDNKKNRTKKKPT----PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNK 204

Query: 1136 YSI---LQTARLLPGAPQQPPKARTG------ISKPYNV--KQIKTTNAQEAEAAIRCLL 1184
             S    + TA+ +   P  PP + T       ++K   V  K+  TTN Q +        
Sbjct: 205  VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 264

Query: 1185 EARGGASEEALSAVAPRDLEASSE--PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKK 1240
             A+   S E  SA   +DL  +S+   +PTP   K ET    P L  P+ P P  P   K
Sbjct: 265  SAKETQSIEKTSA---KDLAPTSKVLAKPTP---KAETTTKGPALTTPKEPTPTTP---K 315

Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPK----PRTFQPGK 1296
                 T K  +P           TI    T+ + P   T    P  PK      T +P  
Sbjct: 316  EPASTTPKEPTPT----------TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 365

Query: 1297 AAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA 1342
               +        + AP    ++   P E  P  PK P       PA
Sbjct: 366  TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411



 Score = 39.3 bits (90), Expect = 0.029
 Identities = 54/261 (20%), Positives = 90/261 (34%), Gaps = 27/261 (10%)

Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASIS-----SGTHGQYSILQTARLLPGAPQQPPKART 1157
            R P+PP +      +  ++   + S+S     S +    S   T R +  +      A  
Sbjct: 94   RSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSA--ANR 151

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217
             + K   VK  K    ++       +++  G   +     V   D   +S  +    +  
Sbjct: 152  ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPD---TSTTQHNKVSTS 208

Query: 1218 PETPQAPPLLPRRP-PPRVPAIKKPTLR-------------RTGKPLSPEEQFEQQTVHF 1263
            P+   A P+ PR   PP     K+ +L               T K  S + + +  +   
Sbjct: 209  PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 268

Query: 1264 TIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP- 1322
            T    +TS +     +     P PK  T   G A   P    P + + P       P P 
Sbjct: 269  TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT 328

Query: 1323 -LEAPPLVPKVP-PRRKKSAP 1341
             +++ P  PK P P   KSAP
Sbjct: 329  TIKSAPTTPKEPAPTTTKSAP 349


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 77/308 (25%), Positives = 104/308 (33%), Gaps = 24/308 (7%)

Query: 1045 PGPTALAPPS----KSPALTKKKQHPTY-KDDADLVELKRELEAVGEFRHRSPSRSLSVP 1099
            P PT    P+    K PA T  K  PT  K+ A     K       E    +P      P
Sbjct: 404  PAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP--TP 461

Query: 1100 NRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
              P+ P P  + P PT        +    +  T  + +        P  P++P    T  
Sbjct: 462  TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA--------PTTPKEPAPTTTKE 513

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAAKP 1218
              P   K+   T  + A    +   E     ++ A +         + EP PT P    P
Sbjct: 514  PSPTTPKEPAPTTTKSAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570

Query: 1219 ETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
             TP+ P P  P+ P P  P    PT  +   P +P+E             P+      P 
Sbjct: 571  TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 630

Query: 1278 VTAPRVPPVPKPRTFQPGKAAERPSHRKPASDE--APPGAGASVP-PPLEAPPLVPKVPP 1334
              AP  P  P P T +   A   P    P + E  AP    A+ P  P E  P  PK P 
Sbjct: 631  KLAPTTPEKPAPTTPEE-LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 689

Query: 1335 RRKKSAPA 1342
                  PA
Sbjct: 690  PTTPKEPA 697



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 79/328 (24%), Positives = 109/328 (33%), Gaps = 34/328 (10%)

Query: 1045 PGPTAL--APPS-KSPALTKKKQHPTYKDDADLVELKRELEAVGE------FRHRSPSRS 1095
            P PT +  AP + K PA T  K  PT   +      K       +       +  +P+ +
Sbjct: 366  PTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 425

Query: 1096 LSVPNRPRPPQP--PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
             S P  P+ P P  P++P P T    + + +     + T  +     T    P  P++P 
Sbjct: 426  KSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP- 482

Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
             A T   KP      +       E A     E      +E            + EP PT 
Sbjct: 483  -APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 541

Query: 1214 GAAKPETPQAP---------PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
              + P TP+ P         P  P+ P P  P    PT  +   P +P+E     T    
Sbjct: 542  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601

Query: 1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQ------PGK-AAERPSHRKPASDEAPPGAGA 1317
               P+      P  TAP  P    P T +      P K A   P    P + E P     
Sbjct: 602  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 661

Query: 1318 SVPPPL---EAPPLVPKVPPRRKKSAPA 1342
              P P     A P  PK P       PA
Sbjct: 662  EEPAPTTPKAAAPNTPKEPAPTTPKEPA 689



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 71/305 (23%), Positives = 108/305 (35%), Gaps = 31/305 (10%)

Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSR-SLSVPNRPR 1103
            P PT   P   +P  TKK    T K+ A     +       +    +P + + + P +P 
Sbjct: 584  PAPTT--PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 641

Query: 1104 PPQP----PQRPPPPTGLMVKKSA--SDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
            P  P    P  P  PT    ++ A  +  + +  T  + +        P  P++P     
Sbjct: 642  PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 701

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT-PGAA 1216
              + P   K    T  +E           +    E A +           +P PT P   
Sbjct: 702  KETAPTTPKGTAPTTLKEPAPTT----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757

Query: 1217 KPETPQAP-PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI-GPPETSVEA 1274
             P TP+ P P  P+ P P  P    PT  +   P +P++   ++    T  GP  T+ + 
Sbjct: 758  APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 817

Query: 1275 P----PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP--GAGASVPPPLEAPPL 1328
            P    P  TAP  P  P P T         P    P + E PP   +  S P   + P  
Sbjct: 818  PAPTTPKETAPTTPKEPAPTT---------PKKPAPTTPETPPPTTSEVSTPTTTKEPTT 868

Query: 1329 VPKVP 1333
            + K P
Sbjct: 869  IHKSP 873



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 64/274 (23%), Positives = 95/274 (34%), Gaps = 41/274 (14%)

Query: 1095 SLSVPNRPRPPQPPQ----RPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
            +L+ P  P P  P +     P  PT   +K + +     + T        T +  P  P+
Sbjct: 343  ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT--------TTKSAPTTPK 394

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQE----AEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
            +P    T    P   K+   T  +E       +     +     + +  +   P++   +
Sbjct: 395  EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 454

Query: 1207 SEPEPTPGAAK---PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH- 1262
            +  EPTP   K   P T +  P  P+ P P  P    PT  +   P +P+E     T   
Sbjct: 455  TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP 514

Query: 1263 -----------FTIGPPETSVEAPPVVT--APRVPPVPKPRTFQPGKAAERPSHRKPASD 1309
                        T   P T+ E  P  T  AP  P  P P T +   A   P    P + 
Sbjct: 515  SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE-PAPTTPKEPAPTTP 573

Query: 1310 EAPPGAGASVPPPLEAPPLVPK--VPPRRKKSAP 1341
            + P     +   P E  P  PK   P   KK AP
Sbjct: 574  KKP-----APTTPKEPAPTTPKEPAPTTTKKPAP 602



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 72/286 (25%), Positives = 104/286 (36%), Gaps = 47/286 (16%)

Query: 1079 RELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM---VKKSASDASISSGTHGQ 1135
            REL+   + +    +R+   P     P+PP      +GL     K +  D S +   H +
Sbjct: 192  RELQKKLKVKDNKKNRTKKKPT----PKPPVVDEAGSGLDNGDFKVTTPDTSTTQ--HNK 245

Query: 1136 YSI---LQTARLLPGAPQQPPKARTG------ISKPYNV--KQIKTTNAQEAEAAIRCLL 1184
             S    + TA+ +   P  PP + T       ++K   V  K+  TTN Q +        
Sbjct: 246  VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 305

Query: 1185 EARGGASEEALSAVAPRDLEASSE--PEPTPGAAKPETPQAPPLL--PRRPPPRVPAIKK 1240
             A+   S E  SA   +DL  +S+   +PTP   K ET    P L  P+ P P  P   K
Sbjct: 306  SAKETQSIEKTSA---KDLAPTSKVLAKPTP---KAETTTKGPALTTPKEPTPTTP---K 356

Query: 1241 PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPK----PRTFQPGK 1296
                 T K  +P           TI    T+ + P   T    P  PK      T +P  
Sbjct: 357  EPASTTPKEPTPT----------TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 406

Query: 1297 AAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA 1342
               +        + AP    ++   P E  P  PK P       PA
Sbjct: 407  TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452



 Score = 39.3 bits (90), Expect = 0.029
 Identities = 54/261 (20%), Positives = 90/261 (34%), Gaps = 27/261 (10%)

Query: 1103 RPPQPPQRPPPPTGLMVKKSASDASIS-----SGTHGQYSILQTARLLPGAPQQPPKART 1157
            R P+PP +      +  ++   + S+S     S +    S   T R +  +      A  
Sbjct: 135  RSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSA--ANR 192

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217
             + K   VK  K    ++       +++  G   +     V   D   +S  +    +  
Sbjct: 193  ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPD---TSTTQHNKVSTS 249

Query: 1218 PETPQAPPLLPRRP-PPRVPAIKKPTLR-------------RTGKPLSPEEQFEQQTVHF 1263
            P+   A P+ PR   PP     K+ +L               T K  S + + +  +   
Sbjct: 250  PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 309

Query: 1264 TIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP- 1322
            T    +TS +     +     P PK  T   G A   P    P + + P       P P 
Sbjct: 310  TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT 369

Query: 1323 -LEAPPLVPKVP-PRRKKSAP 1341
             +++ P  PK P P   KSAP
Sbjct: 370  TIKSAPTTPKEPAPTTTKSAP 390


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 81/322 (25%), Positives = 104/322 (32%), Gaps = 33/322 (10%)

Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP----KART 1157
            P PP  PQ PPP  G   +          G   Q          PG PQ PP    K+R+
Sbjct: 51   PSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS 110

Query: 1158 GISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAK 1217
              S P                      + +G   +       P       +  P  G  K
Sbjct: 111  PRSPPG---------------------KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 149

Query: 1218 PETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPV 1277
            P+ P  PP  P+ PPP+     + +    GKP  P  Q   Q       P +     P  
Sbjct: 150  PQGP-PPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 208

Query: 1278 VTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335
               P+ PP P KP+   P G    + +   P   + PP  G + P     PP  P+ PP 
Sbjct: 209  GNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 268

Query: 1336 RKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGH---PPAAGTVFPQGDFLSTSSATSP 1392
            +  + P                G    SS SP G    PP  G   PQG          P
Sbjct: 269  QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 328

Query: 1393 DSDGTKAMKPEAAPLLGDYQDP 1414
               G    KP+  P  G  Q P
Sbjct: 329  PPQG--GNKPQGPPPPGKPQGP 348



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 17/324 (5%)

Query: 1100 NRPRPPQPPQRP--PPPTGLMVKKSASDASISSGTHGQ-YSILQTARLLPGAPQQPP--- 1153
            N+P+ P PP +P  PPP G   +   S      G   Q  +  Q     PG PQ PP   
Sbjct: 87   NKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 146

Query: 1154 -KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPT 1212
                 G   P   +        ++ ++     + +G   +       P       +  P 
Sbjct: 147  GNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 206

Query: 1213 PGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSV 1272
             G  KP+ P  PP  P+ PPP+     +      GKP  P  Q   Q       P +   
Sbjct: 207  QGGNKPQGP-PPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 265

Query: 1273 EAPPVVTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVP 1330
              P     P+ PP P KP+   P G +  R S   P   + PP  G + P     PP  P
Sbjct: 266  PPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 325

Query: 1331 KVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSAT 1390
            + PP +  + P                G    S+ SP G P       PQ +    +   
Sbjct: 326  QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGP----PQQE--GNNPQG 379

Query: 1391 SPDSDGTKAMKPEAAPLLGDYQDP 1414
             P   G    +P+A P  G  Q P
Sbjct: 380  PPPPAGGNPQQPQAPP-AGQPQGP 402



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 65/261 (24%), Positives = 92/261 (35%), Gaps = 12/261 (4%)

Query: 1092 PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSIL-QTARLLPGAPQ 1150
            P +  + P  P PP  PQ PPP      + S S      G   Q     Q     PG PQ
Sbjct: 143  PPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 202

Query: 1151 QPP----KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEAS 1206
             PP        G   P   +        ++++A     + +G   +       P      
Sbjct: 203  GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGK 262

Query: 1207 SEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
             +  P  G  KP+ P  PP  P+ PPP+  +  + +    GKP  P  Q   Q       
Sbjct: 263  PQGPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 321

Query: 1267 PPETSVEAPPVVTAPRVPPVP-KPRTFQP-GKAAERPSHRKPASDEAPPGAGAS----VP 1320
            P +     P     P+ PP P KP+   P G +  R +   P   + PP    +     P
Sbjct: 322  PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP 381

Query: 1321 PPLEAPPLVPKVPPRRKKSAP 1341
            PP    P  P+ PP  +   P
Sbjct: 382  PPAGGNPQQPQAPPAGQPQGP 402



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 67/286 (23%), Positives = 90/286 (31%), Gaps = 43/286 (15%)

Query: 1184 LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTL 1243
            L +    +E+     +P  +  + +  P  G  KP+ P +PP  P+ PPP+     +   
Sbjct: 13   LSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPP 72

Query: 1244 RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP-KPRTFQPGKAAERPS 1302
               GKP  P              PP+           P+ PP P KP+   P     R  
Sbjct: 73   PPPGKPQGP--------------PPQGG-------NKPQGPPPPGKPQGPPPQGDKSRSP 111

Query: 1303 HRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYN 1362
               P   + PP  G + P     PP  P+ PP +  + P                     
Sbjct: 112  RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171

Query: 1363 SSDSPSGH---PPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLL 1419
            SS SP G    PP  G   PQG          P   G    KP+  P  G  Q P     
Sbjct: 172  SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGP----- 224

Query: 1420 HHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPP 1465
                           D      RSP   P  P   G +  +   PP
Sbjct: 225  -----------PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 41/152 (26%), Positives = 55/152 (36%), Gaps = 7/152 (4%)

Query: 1092 PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSIL-QTARLLPGAPQ 1150
            P +  + P  P PP  PQ PPP  G   + S S      G   Q     Q     PG PQ
Sbjct: 267  PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210
             PP    G +KP              +   +    +R   S        P+    + +  
Sbjct: 327  GPPPQ--GGNKPQGPPPPGKPQGPPPQGGSK----SRSARSPPGKPQGPPQQEGNNPQGP 380

Query: 1211 PTPGAAKPETPQAPPLLPRRPPPRVPAIKKPT 1242
            P P    P+ PQAPP    + PPR P   +P+
Sbjct: 381  PPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPS 412


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 96/367 (26%), Positives = 131/367 (35%), Gaps = 62/367 (16%)

Query: 1045 PGPTALA-PPSKSP--ALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSV--- 1098
            P P+A   PP++ P  +++   +H T +         R   + G    R  SRSLS    
Sbjct: 183  PAPSARPRPPTEGPRKSVSSASEHSTTEPSP----AARRRPSAGGGLQRPASRSLSSSAT 238

Query: 1099 ----PNRPRP-----PQPPQRP--PPPTGLM------VKKSASDASISSGTHGQYSILQT 1141
                P R  P     P+ P  P  P P GL       V     DA+ + G      +   
Sbjct: 239  PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 298

Query: 1142 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR 1201
            +   P +P  PP  +T  S P       TT+               G  + +A  +  P 
Sbjct: 299  SPSAPPSPSAPPSLQTLPSPPATPPSQATTSL--------------GSPTLQATHSFLP- 343

Query: 1202 DLEASSEPEPTPGAAKPETPQAPPLL---PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQ 1258
                   P  +P A  P  PQAPP L   P + PP  PA    +   T  P +P      
Sbjct: 344  ------SPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395

Query: 1259 QTVHFTIGPPETSVEAP-PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGA 1317
                    PP   V+AP     +P V P   P +  P   A  P    P+   +PP + +
Sbjct: 396  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 455

Query: 1318 SVPPPL-----EAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
            + PPP       APPL    PP +   A A   LQ L S      G    +  SPS   P
Sbjct: 456  ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG---QAPFSPSASLP 512

Query: 1373 AAGTVFP 1379
             +    P
Sbjct: 513  MSPLATP 519



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 80/338 (23%), Positives = 111/338 (32%), Gaps = 26/338 (7%)

Query: 1045 PGPTALAPPSKSPALTKKKQHPTYKDDADLVEL-KRELEAVGEFRHRSPSRSLSVPNRPR 1103
            P P+A   PS  P+L      P          L    L+A   F    P   L+ P    
Sbjct: 298  PSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357

Query: 1104 PPQ----PPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
            PP     P Q PP P         +  S  +       +LQ     P +P          
Sbjct: 358  PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
            S P +      + A  + AA    +     AS                 P  TP    P 
Sbjct: 418  SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SPSATPPPQAPP 464

Query: 1220 TPQAPPLLPRRPPPRVP-AIKKPTLRRTGKPLS--PEEQFEQQTVHFTIGPPETSV-EAP 1275
               APPL   +PPP+ P A+  P L+    P +  P +     +    + P  T   +AP
Sbjct: 465  PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 524

Query: 1276 PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335
            PV+ AP +   P P      +A  RP    P +  + P    ++ P    PP  P   P 
Sbjct: 525  PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPS 581

Query: 1336 RKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
               S P  A H     S  + L+G         +  PP
Sbjct: 582  STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 619



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 101/424 (23%), Positives = 137/424 (32%), Gaps = 71/424 (16%)

Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASIS-------SGTHGQYSILQTA-RLLPGAPQQPP 1153
            PRPP  P+ PPP T   ++   +  ++        +G  G  +I ++A R  P    +PP
Sbjct: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86

Query: 1154 KARTG-------------ISKPYNVKQIKTTNAQEAEAAIRCLLE---ARGGASE----E 1193
             +  G             +S P       T      +  +R   E   ARG A+E     
Sbjct: 87   ASGRGERAPPAKNTSPGPVSSPGRASG-TTRPGPLGQKGLRISAEETVARGKATEAPKRS 145

Query: 1194 ALSAVAPRDLEASSEPEPTPGAAKPE--------TPQAPPLLPRRPPPRVP--------- 1236
            ALSA A RD    +   P+P  A+           P+  P    RPP   P         
Sbjct: 146  ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 205

Query: 1237 ---AIKKPTLRRT----GKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKP 1289
                   P  RR     G    P  +    +      P  +   A     AP  P  PKP
Sbjct: 206  HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP 265

Query: 1290 RTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAP----PLVPKVPP--RRKKSAPAA 1343
            +    G  A RP    P   +A P  G     PL  P    P  P  PP  +   S PA 
Sbjct: 266  K----GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT 321

Query: 1344 FHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPE 1403
               Q   S        T++   SP   P A                  P    +  + P 
Sbjct: 322  PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381

Query: 1404 AAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAEL 1463
            A P     Q P    +H   LL   +    S P+ +    P   P+ P +   S A   L
Sbjct: 382  ATP---SPQAPNALAVH---LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 435

Query: 1464 --PP 1465
              PP
Sbjct: 436  AAPP 439


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 73/278 (26%), Positives = 111/278 (39%), Gaps = 40/278 (14%)

Query: 1090 RSPSRSLSVPNRPRPPQPPQRP--PPPTGLMVKKSASDASISSGTHGQYSILQTARL--L 1145
            ++ S  L+ P+   PP P   P   PP+ L      + +SI++        L +  L  L
Sbjct: 547  QTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGL 606

Query: 1146 PGAPQQP-----PKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1200
            P  P  P     P+A   ++ P     ++   +  A   +  L       S +A +A+A 
Sbjct: 607  PSPPLSPLATPPPQAPPXLALP----PLQAPPSPPASPPLSPLATP----SPQAPNALAV 658

Query: 1201 RDLEASSEPEPTPGAAKPETPQA-PPLLPRRPPPRV--PAIKKPTLRRTGKPLSPEEQFE 1257
              L+A   P P+P    P +P A PP+ P   PP    P++  P L+    P +      
Sbjct: 659  HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 718

Query: 1258 QQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKP-----ASDEAP 1312
              T      PP    +APP + AP +   P P    P   +  P  R P        + P
Sbjct: 719  SAT------PPP---QAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVP 769

Query: 1313 PGAGASVP------PPLEAPPLVPKVPPRRKKSAPAAF 1344
            P   AS+P      PP +APP +   P +   S PA+F
Sbjct: 770  PSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASF 807



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 89/374 (23%), Positives = 129/374 (34%), Gaps = 81/374 (21%)

Query: 1081 LEAVGEFRHRSPSR---SLSVPNRPR---PPQPPQRPP------PPTGLMVKKSASDASI 1128
            L+A   F   SP +   SL+ P+RP    P  PP + P      PP    +  + S  S 
Sbjct: 423  LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482

Query: 1129 SSGTHGQYSILQTARLLPGAP-----QQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCL 1183
                H   ++   A   P AP       P + ++ ++ P     ++T  A      +   
Sbjct: 483  PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPP----SLQTPPASLTTPPL--- 535

Query: 1184 LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETP-----QAPPLLPRRPPPRV--- 1235
                     E L ++AP  L+ +S P  TP    P  P     QAPP     PPP     
Sbjct: 536  ---------ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSS 586

Query: 1236 ---------PAIKKPTLR-RTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPP 1285
                     PA+  P L+     PLSP      Q       PP  +  +PP   +P + P
Sbjct: 587  IATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPP--ASPPLSP 644

Query: 1286 VPKPRTFQPGKAA-----------ERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPP 1334
            +  P    P   A             P  + P S  A P    S  PP +APP +   P 
Sbjct: 645  LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 704

Query: 1335 RRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDS 1394
            +   S PA+               ++ +++  P   PP A         +  S   SP  
Sbjct: 705  QVPPSPPAS-------------PPMSPSATPPPQAPPPLAAPPLQ----VPPSPPASPPM 747

Query: 1395 DGTKAMKPEAAPLL 1408
              +    P   PLL
Sbjct: 748  SPSATPPPRVPPLL 761



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 69/278 (24%), Positives = 97/278 (34%), Gaps = 49/278 (17%)

Query: 1104 PPQPPQRPPP--PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPK-ARTGIS 1160
            PP P   PPP  P+ +      +  +++S           + L    PQ PP  A   + 
Sbjct: 572  PPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQ 631

Query: 1161 KPYN------VKQIKTTNAQEAEAAIRCLLEA----------RGGASEEALSAVAPRDLE 1204
             P +      +  + T + Q   A    LL+A          +   S  A   V+P    
Sbjct: 632  APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 691

Query: 1205 ASSEPE----------PTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEE 1254
             S  P           P+P A+ P +P A P     PP   P ++ P       P+SP  
Sbjct: 692  PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSA 751

Query: 1255 QFEQQTVHFTIGPP-----------------ETSVEAPPVVTAPRVPPVPKPRTFQPGKA 1297
                +       PP                 +   +APP +  P +  +P P    PG+A
Sbjct: 752  TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQA 811

Query: 1298 AERPSHRKPASDEAPPGAGASVPPPLEAPPL-VPKVPP 1334
               PS   P S  A P   A  PP L AP L VP  PP
Sbjct: 812  PFSPSASLPMSPLATPPPQA--PPVLAAPLLQVPPSPP 847



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 92/375 (24%), Positives = 134/375 (35%), Gaps = 68/375 (18%)

Query: 1091 SPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
            +P RS       R    P  P  P+  M ++S +     +GT      +   R  P A  
Sbjct: 150  APKRSALSAGARRDTSGPT-PGTPSPAMARRSRA-----AGTE-----VGLPRPAPSARP 198

Query: 1151 QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPE 1210
            +PP    G  K  +V      +  E   A R    A GG     L   A R L +S+ P 
Sbjct: 199  RPPTE--GPRK--SVSSASEHSTTEPSPAARRRPSAGGG-----LQRPASRSLSSSATPL 249

Query: 1211 PTPGAAKPE---TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGP 1267
             +P  + P    TP+AP    +  P  + A++ P +    K  +P            +GP
Sbjct: 250  SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP-----------ALGP 298

Query: 1268 PETSVEAPPVVTAPRVPPVPKP--------RTFQPGKAAERPSHRKPASDEAPP------ 1313
              +S  A P  +  +  PVP P         T  P      P    P S  APP      
Sbjct: 299  LSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLP 358

Query: 1314 ---------GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSS 1364
                        +   PP++APP +  +PP +   +  +  LQ   S   L       S 
Sbjct: 359  SPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL 418

Query: 1365 DSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKL 1424
             SP+    A  +        + +S TSP      +  P++ PL    Q P  +L   P L
Sbjct: 419  GSPT--LQATHSFLTMSPRQTQASLTSPSRPA--STPPDSPPL----QAPL-SLPASPPL 469

Query: 1425 LNNTWLSKSSDPLDS 1439
               T LS +  PL S
Sbjct: 470  --QTSLSPAVSPLSS 482



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 68/291 (23%), Positives = 100/291 (34%), Gaps = 38/291 (13%)

Query: 1096 LSVPNRPRPPQPPQRPP--PPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
            L  P  P PP PP + P  PP    V  SA+  S +  +     +    ++ P  P  PP
Sbjct: 661  LQAPFSP-PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL----QVPPSPPASPP 715

Query: 1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP 1213
             + +    P     +     Q   +                  A  P    A+  P   P
Sbjct: 716  MSPSATPPPQAPPPLAAPPLQVPPSP----------------PASPPMSPSATPPPRVPP 759

Query: 1214 GAAKP--ETPQAPPL------LPRRPPPRVPAIKKPTLRRTGKPLS--PEEQFEQQTVHF 1263
              A P  + P +PP       L + PP   PA+  P L+    P +  P +     +   
Sbjct: 760  LLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 819

Query: 1264 TIGPPETSV-EAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPP 1322
             + P  T   +APPV+ AP +   P P      +A  RP    P +  + P    ++ P 
Sbjct: 820  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP- 878

Query: 1323 LEAPPLVPKVPPRRKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
               PP  P   P    S P  A H     S  + L+G         +  PP
Sbjct: 879  --GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 927



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 97/383 (25%), Positives = 135/383 (35%), Gaps = 95/383 (24%)

Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGA--PQQPPKARTGI 1159
            PRPP  P RPPPP    V  +A     ++G  G+  + + A  + GA  P+  P+A    
Sbjct: 27   PRPPGSP-RPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA---- 77

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
                     ++        A R     RG          AP     S  P  +PG A   
Sbjct: 78   ------GPTRSAGTSSRNPASRPPASGRGER--------APPAKNTSPGPVSSPGRASGT 123

Query: 1220 TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEA-PPVV 1278
            T         RP P         L + G  +S EE   +     T  P  +++ A     
Sbjct: 124  T---------RPGP---------LGQKGLRISAEETVARGKA--TEAPKRSALSAGARRD 163

Query: 1279 TAPRVPPVPKPRTFQPGKAA------ERPSHRKPASDEAPP--GAGASVPPPLEAPPLVP 1330
            T+   P  P P   +  +AA       RP+   P++   PP  G   SV    E     P
Sbjct: 164  TSGPTPGTPSPAMARRSRAAGTEVGLPRPA---PSARPRPPTEGPRKSVSSASEHSTTEP 220

Query: 1331 KVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSAT 1390
                RR+ SA         +S   L    T  SS + SG P A GT  P+    + +  +
Sbjct: 221  SPAARRRPSAGGGLQRPASRS---LSSSATPLSSPARSG-PSARGT--PR----APAHPS 270

Query: 1391 SPDSDGTKAMKP--------EAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTR 1442
             P   G +A++P        +AAP LG                     S  + P  SGT 
Sbjct: 271  QPKPKGLQALRPPQVTPPRKDAAPALGPLSS-----------------SPLATPSPSGT- 312

Query: 1443 SPKRDPIDPVSAGASAAKAELPP 1465
              K  P+ P    A+   A LPP
Sbjct: 313  --KARPVPPPDNAATPLPATLPP 333



 Score = 31.2 bits (69), Expect = 7.8
 Identities = 75/286 (26%), Positives = 100/286 (34%), Gaps = 47/286 (16%)

Query: 1051 APPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSP-SRSLSVPNRPRPPQPPQ 1109
            +PP+  P     K  P          L+        F  ++P S S S+P  P    PPQ
Sbjct: 771  SPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830

Query: 1110 RPPPPTGLMVKKSAS-------DASISSGTHGQYSILQTARL-LPGAPQQPPKARTGISK 1161
             PP     +++   S        A     T G  + +   RL L  AP  PP      S 
Sbjct: 831  APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 890

Query: 1162 PYNVKQIKTTNAQEAEAAIRCLLEARG--GASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
              +   +    A  + +A     E RG     E   +A  P D E ++   P   +  P 
Sbjct: 891  TLSGPDL----AGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA-CHPAAWSRGPA 945

Query: 1220 TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVT 1279
             P A    P  P P  PA        TG    P       T++ T G PE++  AP    
Sbjct: 946  PPLAFRGAPGAPLPWPPA--------TG----PGSADGLCTIYETEG-PESATPAPGA-- 990

Query: 1280 APRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEA 1325
               + P P P T   GKAA            A  GAGAS   P +A
Sbjct: 991  ---LDPGPSPGT-SGGKAA------------AGAGAGASSRSPKQA 1020


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 73/277 (26%), Positives = 102/277 (36%), Gaps = 41/277 (14%)

Query: 1093  SRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQP 1152
             S  +  P +P     P++ PP     V K                +++    +P  P+ P
Sbjct: 10446 SEKIIPPKKPPTKVVPRKEPPAKVPEVPKKI--------------VVEEKVRVPEEPRVP 10491

Query: 1153  PKARTGISKPYNV---KQIKTTNAQEAEAAIRCLLEA-RGGASEEALSAVAPRDLEASSE 1208
             P     +  P  V   K++    A++ EA    + EA +    E+ +    P+  E    
Sbjct: 10492 PTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT 10551

Query: 1209  PEP-TPGAAKPE--TPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTI 1265
               P  P AA PE   P+A P  P  PPP VP   K  +     P +P ++ E   V    
Sbjct: 10552 KVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPE 10611

Query: 1266  GP----PETSVEAP----PVVTAPRVPPVPK---PRTFQPGKAAERPSHRKPASDEAPPG 1314
              P    PE  V  P    P V   +VP VPK   P    P     +P    P   E P  
Sbjct: 10612 APKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEE 10671

Query: 1315  AGASVPP------PLEAPPLVPKVPPRR---KKSAPA 1342
                  PP      P  A P    VPP++   +K APA
Sbjct: 10672 VALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPA 10708



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 93/383 (24%), Positives = 147/383 (38%), Gaps = 75/383 (19%)

Query: 998   EENFDFTSLDYESEGDILEDDEDY-LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKS 1056
             EE  ++   DY+ E +  E  E+Y   +E+ +      E   + +++   P  + P  + 
Sbjct: 9743  EEYEEYEEYDYK-EFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEE 9801

Query: 1057  PALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTG 1116
             P  TK K  P           K   +AV E +   P     +P + +PP PP+ P  P  
Sbjct: 9802  PVPTKPKAPPA----------KVLKKAVPEEKVPVP-----IPKKLKPP-PPKVPEEPKK 9845

Query: 1117  LMVKKSASDASISSGTHGQYSILQTARLLPGAP------QQPPKARTGISKPYNVKQIK- 1169
             +  +K      IS     +  + + A  +P  P      ++ P  R  ++ P  V ++  
Sbjct: 9846  VFEEK----IRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPK 9901

Query: 1170  -------------TTNAQE--AEAAIRCLLEARGGASEEALSAVAPRDLE------ASSE 1208
                           T+ +E   E     + E     +EE +  V P  +          E
Sbjct: 9902  ELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEE 9961

Query: 1209  PEPTPGAAKPETPQAP-PLLPRRPPPRVPAI--KKPTLRRTGKPLSPEEQFEQQTVHFTI 1265
              +P P   K E P A  P +P++P  +VP +  KK        P  P++   ++ V    
Sbjct: 9962  KKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPV-- 10019

Query: 1266  GPPETSVEAPPVVTAPRVPP---------VPKPRTFQ--PGKAAERPSHRKPASDEAPPG 1314
              P    VEAPP    P VP          VP P+  +  P K  E P    P   +  P 
Sbjct: 10020 -PVPKKVEAPPA-KVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTP- 10076

Query: 1315  AGASVPPPLEAPPLVPKVPPRRK 1337
                 VP  +EAPP  PKVP +R+
Sbjct: 10077 ----VPKKVEAPP--PKVPKKRE 10093



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 74/320 (23%), Positives = 112/320 (35%), Gaps = 54/320 (16%)

Query: 1052  PPSKSPALTK----KKQHPTY---KDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRP 1104
             PP+K P + K    +K+ P     K ++   E+  E E V       P+  +  P    P
Sbjct: 10633 PPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVA--LEEPPAEVVEEPEPAAP 10690

Query: 1105  PQ---PPQRPPP----PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKART 1157
             PQ   PP++P P    P  +  K       +           +   ++P  P+ PP    
Sbjct: 10691 PQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVP 10750

Query: 1158  GISK-----------------PYNVKQIKTTNAQEAEAAIRCLLEARGGASE--EALSAV 1198
              + K                 P  V ++      E + A+     A     E  E    +
Sbjct: 10751 EVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEI 10810

Query: 1199  APRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQ 1258
             AP +  A  E +P P A + E    PP +P  P   +P  K P +++   P   E +   
Sbjct: 10811 APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPE--- 10867

Query: 1259  QTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGAS 1318
                      PE  +E P +   P  PP   P+     K  +  +  K    E P      
Sbjct: 10868 ---------PEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKP-----Q 10913

Query: 1319  VPPPLEAPPLVPKVPPRRKK 1338
             VP  +E  PL  KVP   KK
Sbjct: 10914 VPEKVELTPL--KVPGGEKK 10931



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 78/332 (23%), Positives = 122/332 (36%), Gaps = 63/332 (18%)

Query: 1008  YESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPT 1067
             YE   +I  ++E    +E   P   + E      +    P  + P  K P + K +  P 
Sbjct: 10804 YEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPP 10863

Query: 1068  YKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDAS 1127
              + + + V  K +L                   +PRPP PP  P PP   + +K     +
Sbjct: 10864 KEPEPEKVIEKPKL-------------------KPRPPPPP--PAPPKEDVKEKIFQLKA 10902

Query: 1128  ISSGTHGQYSILQTARLLPGAPQQPPKAR-TGISKPYNVKQIKTTNAQ-----EAEAAIR 1181
             I              + +P  PQ P K   T +  P   K+++    +     + E  ++
Sbjct: 10903 IPK------------KKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLK 10950

Query: 1182  CLLEARGGASEEALSAVAPRDLEASSEPE-PTPGAAKPETPQAPPLLPRRP-----PPRV 1235
              +L  R    EE    V P+ LE   +P  P P   KP      P + +R      P +V
Sbjct: 10951 SVLRKR---PEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKV 11007

Query: 1236  PAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPG 1295
             P IK P +        P+ + E +T+     PP    E  P+     VP V        G
Sbjct: 11008 PEIK-PAIPLPAPEPKPKPEAEVKTIK----PPPVEPEPTPIAAPVTVPVV--------G 11054

Query: 1296  KAAERPSHRKPASDEAPP--GAGASVPPPLEA 1325
             K AE  + ++ A+    P  G     P P+EA
Sbjct: 11055 KKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEA 11086



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 66/261 (25%), Positives = 93/261 (35%), Gaps = 57/261 (21%)

Query: 1092  PSRSLSVPNRPRPPQPPQRPPP-PTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
             P + + VP   +P  PP + P  P   + +K   +A                  +P  P+
Sbjct: 10534 PEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEA------------------IPPKPE 10575

Query: 1151  QPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL-EASSE- 1208
              PP                    +  EA    + E +  A+      V P  + EA  E 
Sbjct: 10576 SPPP-------------------EVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEV 10616

Query: 1209  -PEPTPGAAKPETPQAPPL-LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIG 1266
              PE       P+ P+ PP  +P  P   VP  K P          P E FE+        
Sbjct: 10617 VPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEE 10676

Query: 1267  PPETSVE-----APPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP 1321
             PP   VE     APP VT P   PVP+ +   P   A++P        E PP     VP 
Sbjct: 10677 PPAEVVEEPEPAAPPQVTVPPKKPVPEKKA--PAVVAKKP--------ELPPVKVPEVPK 10726

Query: 1322  PLEAPPLVPKVPPRRKKSAPA 1342
              +     VP V P++ ++ PA
Sbjct: 10727 EVVPEKKVPLVVPKKPEAPPA 10747



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 74/310 (23%), Positives = 119/310 (38%), Gaps = 30/310 (9%)

Query: 1044  VPGPTA-LAPPSKSPALTKKKQHPTYKDDADLVELKRE--LEAVGEFRHRS--------- 1091
             VP P   +APP + P + K+ +      + ++V    E  +E   E+ H           
Sbjct: 9883  VPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEV 9942

Query: 1092  -PSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQ 1150
              P   + VP  PR P P ++ P P  +  KK A  A +          +    L+P   +
Sbjct: 9943  VPVIPVKVPEVPRKPVPEEKKPVP--VPKKKEAPPAKVPEVPKKPEEKVPV--LIPKKEK 9998

Query: 1151  QPP-KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEA-RGGASEEALSAVAPRDLEASSE 1208
              PP K      KP   +++     ++ EA    + E  +    E+ +   AP+ +EA   
Sbjct: 9999  PPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPA 10058

Query: 1209  PEP-TPGAAKPETPQAPPLLPRR---PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
               P  P    PE  +  P+ P++   PPP+VP  ++P       P   E  FE++ V   
Sbjct: 10059 KVPEVPKKLIPEEKKPTPV-PKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIV--- 10114

Query: 1265  IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRK-PASDEAPPGAGASVPPPL 1323
               P E  +     V       +P+     P +    P   + P  +E  P     VP   
Sbjct: 10115 --PEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEE 10172

Query: 1324  EAPPLVPKVP 1333
               P + PKVP
Sbjct: 10173 VLPEVKPKVP 10182



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 62/208 (29%), Positives = 82/208 (39%), Gaps = 22/208 (10%)

Query: 1146  PGAPQQPPKARTGI----SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEA------L 1195
             P AP + P+    I      P  V   K   A+  E   + ++E +    EE       +
Sbjct: 10436 PKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKV 10495

Query: 1196  SAVAPRDLEASSEPEPTPGAAKPET-----PQAP-PLLPRRPPPRVPAIKKPTLRRTGKP 1249
               V P       +  P P A KPE      P+AP  ++P +  P VP  KKP +  T  P
Sbjct: 10496 PEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVP-VPPPKKPEVPPTKVP 10554

Query: 1250  LSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPR-VPPVPKPRTFQPGKAAERPSHRKPAS 1308
               P+    ++ V   I PP+     P V  AP+ V P  K     P K    P     A 
Sbjct: 10555 EVPKAAVPEKKVPEAI-PPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAP 10613

Query: 1309  DEAPPGAGASVPPPL--EAPPL-VPKVP 1333
              E  P     VPPP   E PP  VP+VP
Sbjct: 10614 KEVVPEKKVPVPPPKKPEVPPTKVPEVP 10641



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 40/143 (27%), Positives = 54/143 (37%), Gaps = 11/143 (7%)

Query: 1209 PEPTPGAAKPETPQAPPLLPRRPPPR----VPAIKK-----PTLRRTGKPLSPEEQFEQQ 1259
            P P P   +P  P+ P + P++P P     VP  KK     P +    K   PEE+    
Sbjct: 9302 PVPIPKKVEPPAPKVPEV-PKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP 9360

Query: 1260 TVHFTIGPPETSVEAPP-VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGAS 1318
                   PP    E    VVT  ++  V +     P    E P  + P   +  P     
Sbjct: 9361 VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEE 9420

Query: 1319 VPPPLEAPPLVPKVPPRRKKSAP 1341
            VPPP + P L  K  P  K + P
Sbjct: 9421 VPPPPKVPALPKKPVPEEKVAVP 9443



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 63/291 (21%), Positives = 105/291 (36%), Gaps = 26/291 (8%)

Query: 1062  KKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP-PQRPPPPTGLMVK 1120
             ++  PT + D      +RE E   E           +P +P P +P P +P  P   ++K
Sbjct: 9757  EEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLK 9816

Query: 1121  KSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAI 1180
             K+  +  +         +    +L P  P+ P + +    +   +   K    Q  E A 
Sbjct: 9817  KAVPEEKVP--------VPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAA 9868

Query: 1181  RCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETP-QAPPLLPRRPPPRVPAIK 1239
             +  ++ +   +EE +    PR        E  P    PE P +  P         V  ++
Sbjct: 9869  KVPMKPKRVVAEEKVPV--PRK-------EVAPPVRVPEVPKELEPEEVAFEEEVVTHVE 9919

Query: 1240  KPTLRRTGKPLSPEEQFEQQTVHFTIGPPET-SVEAPPVVTAPRVPPVPKPRTFQPGKAA 1298
             +  +    + +  EE+F  +     + P +   V   PV    +  PVPK +   P K  
Sbjct: 9920  EYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVP 9979

Query: 1299  E---RPSHRKPA---SDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAA 1343
             E   +P  + P      E PP A     P    P     VP  +K  AP A
Sbjct: 9980  EVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPA 10030



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 40/134 (29%), Positives = 52/134 (38%), Gaps = 17/134 (12%)

Query: 1219  ETPQAPPLLPRRPPPRVPAIKKPT--LRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPP 1276
             E P+APP  P      +P  K PT  + R   P    E  ++  V   +  PE      P
Sbjct: 10434 EKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPE-----EP 10488

Query: 1277  VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPL-------EAPPLV 1329
              V   +VP V  P+   P K    P  +KP   EAPP      P  +         PP  
Sbjct: 10489 RVPPTKVPEVLPPKEVVPEKKVPVPPAKKP---EAPPPKVPEAPKEVVPEKKVPVPPPKK 10545

Query: 1330  PKVPPRRKKSAPAA 1343
             P+VPP +    P A
Sbjct: 10546 PEVPPTKVPEVPKA 10559



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 43/153 (28%), Positives = 60/153 (39%), Gaps = 18/153 (11%)

Query: 1193 EALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP 1252
            E +   + R  E   +    P  +K   PQ P   P +    V  +K P +      +S 
Sbjct: 9187 EKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQE--EVIEVKVPAVHTKKMVISE 9244

Query: 1253 EEQF----EQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPAS 1308
            E+ F     ++ V  T+  PE   E   +VT  ++      R   P K  E P   KPA 
Sbjct: 9245 EKMFFASHTEEEVSVTV--PEVQKE---IVTEEKIHVAISKRVEPPPKVPELPE--KPAP 9297

Query: 1309 DEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAP 1341
            +E  P     VP P +  P  PKVP   KK  P
Sbjct: 9298 EEVAP-----VPIPKKVEPPAPKVPEVPKKPVP 9325



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 77/329 (23%), Positives = 122/329 (37%), Gaps = 63/329 (19%)

Query: 1044  VPGPTAL-APPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRP 1102
             VP P  + APP+K P + KK       ++     + +++EA                  P
Sbjct: 10047 VPAPKKVEAPPAKVPEVPKK----LIPEEKKPTPVPKKVEA------------------P 10084

Query: 1103  RPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKP 1162
              P  P +R P P  + + +             +  + +   +LP   +  P+    + + 
Sbjct: 10085 PPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEE 10144

Query: 1163  YNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQ 1222
               +   +     E E       E      EE L  V P+       P P P   K  T +
Sbjct: 10145 EEIPPEEEEVPPEEEYVPE---EEEFVPEEEVLPEVKPK----VPVPAPVPEIKKKVT-E 10196

Query: 1223  APPLLPRR---PPPRVPAI-KKPTLRRTGKPLSPE-------EQFEQQTVHFTIGPPET- 1270
                ++P++   PP +VP + KK   +R   P   E       E+ E++ +     P E  
Sbjct: 10197 KKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP 10256

Query: 1271  SVEAPPVVTAPRVP------------PVPKPRTFQPGKAAER-PSHRKPA---SDEAPPG 1314
             S+E    V  PRVP            PVPK     P K +++ P  + P      EAPP 
Sbjct: 10257 SIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPA 10316

Query: 1315  AGASVPPPL-EAPPLVPK---VPPRRKKS 1339
                 VP  + E   LVPK   VPP + ++
Sbjct: 10317 KVPEVPKKVPEKKVLVPKKEAVPPAKGRT 10345



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 81/352 (23%), Positives = 130/352 (36%), Gaps = 71/352 (20%)

Query: 1044 VPGPTAL---APPSKSPALTK------KKQHPTYKDDAD---LVELKRELEAVGEFRHRS 1091
            +P P A    APP+K P + K      K    T ++++    + E+ ++   V E R   
Sbjct: 9357 IPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKK--KVPEERKPV 9414

Query: 1092 PSRSLSVPNRPRPPQPPQRPPP------PTGLMVKKSASDASISSGT-HGQYSILQTARL 1144
            P +   VP  P+ P  P++P P      P  +  K     A +S  T   +   +   +L
Sbjct: 9415 PRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKL 9474

Query: 1145 LPGAPQQPPKARTGIS-----------KPYNVKQIKTTNAQEAEAA----IRCLLEARGG 1189
                PQ+    R  +S           +  ++   +    +E E A       + E    
Sbjct: 9475 SFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEY 9534

Query: 1190 ASEEALSAVAPRDLEASSEPEPTPGAAKPE-----TPQAPPLLPRRPPPRVPAIKKPTL- 1243
              EE L  ++ R      E EP     + E      P+ P  +   PP +VP   K  + 
Sbjct: 9535 VVEEKLHIISKR-----VEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVP 9589

Query: 1244 -RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPP-VPKPRTFQPGKAAERP 1301
             ++   P+  +E+         + PP+   E    V   +VPP V K     P K  ER 
Sbjct: 9590 EKKVPAPVPKKEK---------VPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTER- 9639

Query: 1302 SHRKPASD----------EAPPGAGASVPPPLEAP-PLVPKVPPRRKKSAPA 1342
             H +   +          EAPP A     P    P   V K+ P+R++  PA
Sbjct: 9640 -HMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPA 9690



 Score = 40.4 bits (93), Expect = 0.013
 Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 11/117 (9%)

Query: 1203  LEASSEPEPTPGAAKPETPQAPPLLPRRP---PPRVPAIKKPTLRRTGKPL-----SPEE 1254
             +E + EPE  P  ++ E P+ PP +       PPRVP + K  +     P+     +P  
Sbjct: 10235 VEVTEEPEEEP-ISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPA 10293

Query: 1255  QFEQQTVHFTIGPPETSVEAPPVVTAPRVP-PVPKPRTFQPGKAAERPSHRKPASDE 1310
             +  ++     +  P    EAPP    P VP  VP+ +   P K A  P+  +   +E
Sbjct: 10294 KVSKKIPEEKVPVPVQKKEAPP-AKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEE 10349



 Score = 38.9 bits (89), Expect = 0.038
 Identities = 78/385 (20%), Positives = 125/385 (32%), Gaps = 98/385 (25%)

Query: 1039 DDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSV 1098
            ++++ VP P  + PP+       KK  P  K    + +             + P+    V
Sbjct: 9298 EEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPK-------------KEPAAPPKV 9344

Query: 1099 PNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHG----QYSILQTAR------LLPGA 1148
            P  P+ P P ++ P P  +  KK A  A +     G    +   + T R       +P  
Sbjct: 9345 PEVPKKPVPEEKIPVP--VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEI 9402

Query: 1149 PQQ------------------PPKARTGISKPYNVKQI-------KTTNAQEAEAAIRCL 1183
            P++                  PPK      KP   +++       K      AE + + +
Sbjct: 9403 PKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTV 9462

Query: 1184 LEARGGASEEALSAVAPRDLEAS----------SEPEPTPGAA----------KPETPQA 1223
            +E +   +EE LS   P+ +E +          S  E   G +          + E  + 
Sbjct: 9463 VEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEV 9522

Query: 1224 PPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPP-ETSVEAPPVVTAPR 1282
                    P      +K  +        P E  E+Q     + P     +E PP    P 
Sbjct: 9523 TEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPE 9582

Query: 1283 VP-----------PVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPK 1331
             P           PVPK     P K  E P  +KP  ++  P     +  PL A     K
Sbjct: 9583 APKKIVPEKKVPAPVPKKEKVPPPKVPEEP--KKPVPEKKVPPKVIKMEEPLPA-----K 9635

Query: 1332 VPPRRKKSAPAAFHLQVLQSNSQLL 1356
            V  R         H+Q+ Q    L+
Sbjct: 9636 VTER---------HMQITQEEKVLV 9651



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 75/354 (21%), Positives = 125/354 (35%), Gaps = 56/354 (15%)

Query: 1010 SEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSD-----------VPGPTALAPPSKSPA 1058
            +E +++E+ E+Y+V+E         E    ++++           +P      PP+K P 
Sbjct: 9523 TEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPE 9582

Query: 1059 LTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLM 1118
              KK           +V  K+    V +     P +   VP  P+ P P ++ PP    +
Sbjct: 9583 APKK-----------IVPEKKVPAPVPKKEKVPPPK---VPEEPKKPVPEKKVPPK---V 9625

Query: 1119 VKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNV---KQIKTTNAQE 1175
            +K      +  +  H Q +  +   +     + PPKAR        V   K +K    +E
Sbjct: 9626 IKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKRE 9685

Query: 1176 AEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRV 1235
             E   +     +    EE +S  AP+      EP+P       E  +    L       V
Sbjct: 9686 EEPPAKVTEFRKRVVKEEKVSIEAPK-----REPQPIKEVTIMEEKERAYTLEEE---AV 9737

Query: 1236 PAIKKPTLR-------RTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVP---- 1284
               ++           +  +   P E+++Q    +     E   E    +T P  P    
Sbjct: 9738 SVQREEEYEEYEEYDYKEFEEYEPTEEYDQYE-EYEEREYERYEEHEEYITEPEKPIPVK 9796

Query: 1285 PVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKK 1338
            PVP+       KA      +K   +E  P     VP P +  P  PKVP   KK
Sbjct: 9797 PVPEEPVPTKPKAPPAKVLKKAVPEEKVP-----VPIPKKLKPPPPKVPEEPKK 9845


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 82/322 (25%), Positives = 117/322 (36%), Gaps = 55/322 (17%)

Query: 1090 RSPSRSLSVPNRPRPP-----QPPQRPPP------------------PTGLMVKKSASDA 1126
            R   R+ + P++P+P      +PPQ  PP                  P+     +S +  
Sbjct: 260  RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP 319

Query: 1127 SISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEA 1186
            ++ +  H      Q A  LP AP  P       S P +++ + +  A     A   L   
Sbjct: 320  TLPATPHSSSLTCQLATPLPLAPPSP-------SAPPSLQTLPSPPATPPSQATTSL--- 369

Query: 1187 RGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL---PRRPPPRVPAIKKPTL 1243
             G  + +A  +  P        P  +P A  P  PQAPP L   P + PP  PA    + 
Sbjct: 370  -GSPTLQATHSFLP-------SPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSP 419

Query: 1244 RRTGKPLSPEEQFEQQTVHFTIGPPETSVEAP-PVVTAPRVPPVPKPRTFQPGKAAERPS 1302
              T  P +P              PP   V+AP     +P V P   P +  P   A  P 
Sbjct: 420  LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 479

Query: 1303 HRKPASDEAPPGAGASVPPPL-----EAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQ 1357
               P+   +PP + ++ PPP       APPL    PP +   A A   LQ L S      
Sbjct: 480  QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539

Query: 1358 GLTYNSSDSPSGHPPAAGTVFP 1379
            G    +  SPS   P +    P
Sbjct: 540  G---QAPFSPSASLPMSPLATP 558



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 82/338 (24%), Positives = 112/338 (33%), Gaps = 28/338 (8%)

Query: 1047 PTALAPPSKS--PALTKKKQHPTYKDDADLVEL-KRELEAVGEFRHRSPSRSLSVPNRPR 1103
            P  LAPPS S  P+L      P          L    L+A   F    P   L+ P    
Sbjct: 337  PLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396

Query: 1104 PPQ----PPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGI 1159
            PP     P Q PP P         +  S  +       +LQ     P +P          
Sbjct: 397  PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 456

Query: 1160 SKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPE 1219
            S P +      + A  + AA    +     AS                 P  TP    P 
Sbjct: 457  SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SPSATPPPQAPP 503

Query: 1220 TPQAPPLLPRRPPPRVP-AIKKPTLRRTGKPLS--PEEQFEQQTVHFTIGPPETSV-EAP 1275
               APPL   +PPP+ P A+  P L+    P +  P +     +    + P  T   +AP
Sbjct: 504  PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 563

Query: 1276 PVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPR 1335
            PV+ AP +   P P      +A  RP    P +  + P    ++ P    PP  P   P 
Sbjct: 564  PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPS 620

Query: 1336 RKKSAP-AAFHLQVLQSNSQLLQGLTYNSSDSPSGHPP 1372
               S P  A H     S  + L+G         +  PP
Sbjct: 621  STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP 658



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 92/385 (23%), Positives = 123/385 (31%), Gaps = 89/385 (23%)

Query: 1102 PRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGA--PQQPPKA---- 1155
            PRPP  P RPPPP    V  +A     ++G  G+  + + A  + GA  P+  P+A    
Sbjct: 27   PRPPGSP-RPPPP----VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTR 81

Query: 1156 ------RTGISKP------YNVKQIKTTN----------------AQEAEAAIRCLLE-- 1185
                  R   S+P            K T+                    +  +R   E  
Sbjct: 82   SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141

Query: 1186 -ARGGASE----EALSAVAPRDLEASSEPEPTPGAAKPE--------TPQAPPLLPRRPP 1232
             ARG A+E     ALSA A RD    +   P+P  A+           P+  P    RPP
Sbjct: 142  VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 201

Query: 1233 PRVP------------AIKKPTLRRT----GKPLSPEEQFEQQTVHFTIGPPETSVEAPP 1276
               P                P  RR     G    P  +    +      P  +   A  
Sbjct: 202  TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARG 261

Query: 1277 VVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPL-----------EA 1325
               AP  P  PKP+    G  A RP    P   +A P  G     PL           +A
Sbjct: 262  TPRAPAHPSQPKPK----GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQA 317

Query: 1326 PPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLS 1385
            PP +P  P     +   A  L +   +      L   +  SP   PP+  T       L 
Sbjct: 318  PPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSL--QTLPSPPATPPSQATTSLGSPTLQ 375

Query: 1386 T--SSATSPDSDGTKAMKPEAAPLL 1408
               S   SP         P+A P L
Sbjct: 376  ATHSFLPSPPLSPLATPPPQAPPAL 400


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,866,620
Number of Sequences: 37866
Number of extensions: 3423158
Number of successful extensions: 34350
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 1175
Number of HSP's that attempted gapping in prelim test: 20298
Number of HSP's gapped (non-prelim): 9385
length of query: 1496
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1381
effective length of database: 13,892,928
effective search space: 19186133568
effective search space used: 19186133568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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