BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|26051273 voltage-gated potassium channel, subfamily H, member 2 isoform c [Homo sapiens] (819 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|26051273 voltage-gated potassium channel, subfamily H, member... 1663 0.0 gi|4557729 voltage-gated potassium channel, subfamily H, member ... 1598 0.0 gi|27886653 potassium voltage-gated channel, subfamily H, member... 903 0.0 gi|13540549 potassium voltage-gated channel, subfamily H, member... 872 0.0 gi|26051271 voltage-gated potassium channel, subfamily H, member... 863 0.0 gi|27886651 potassium voltage-gated channel, subfamily H, member... 759 0.0 gi|27886665 potassium voltage-gated channel, subfamily H, member... 592 e-169 gi|6912446 potassium voltage-gated channel, subfamily H, member ... 478 e-135 gi|27886667 potassium voltage-gated channel, subfamily H, member... 476 e-134 gi|4504831 potassium voltage-gated channel, subfamily H, member ... 473 e-133 gi|27437001 potassium voltage-gated channel, subfamily H, member... 462 e-130 gi|22024390 potassium voltage-gated channel, subfamily H, member... 461 e-130 gi|27886648 potassium voltage-gated channel, subfamily H, member... 461 e-130 gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 448 e-126 gi|27886646 potassium voltage-gated channel, subfamily H, member... 408 e-113 gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 175 2e-43 gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 174 2e-43 gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 173 7e-43 gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 172 1e-42 gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 157 3e-38 gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 157 3e-38 gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 148 2e-35 gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 148 2e-35 gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 140 6e-33 gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 133 6e-31 gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 98 3e-20 gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 95 3e-19 gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 48 3e-05 gi|5031767 heat shock transcription factor 1 [Homo sapiens] 46 2e-04 gi|58530876 melanoma antigen family C, 1 [Homo sapiens] 44 6e-04 >gi|26051273 voltage-gated potassium channel, subfamily H, member 2 isoform c [Homo sapiens] Length = 819 Score = 1663 bits (4306), Expect = 0.0 Identities = 819/819 (100%), Positives = 819/819 (100%) Query: 1 MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTI 60 MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTI Sbjct: 1 MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTI 60 Query: 61 LHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVD 120 LHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVD Sbjct: 61 LHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVD 120 Query: 121 IMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEEL 180 IMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEEL Sbjct: 121 IMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEEL 180 Query: 181 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 240 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD Sbjct: 181 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 240 Query: 241 SRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF 300 SRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF Sbjct: 241 SRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF 300 Query: 301 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY 360 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY Sbjct: 301 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY 360 Query: 361 FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKT 420 FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKT Sbjct: 361 FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKT 420 Query: 421 THAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG 480 THAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG Sbjct: 421 THAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG 480 Query: 481 DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGG 540 DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGG Sbjct: 481 DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGG 540 Query: 541 FSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPES 600 FSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPES Sbjct: 541 FSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPES 600 Query: 601 SEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSF 660 SEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSF Sbjct: 601 SEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSF 660 Query: 661 WGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADM 720 WGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADM Sbjct: 661 WGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADM 720 Query: 721 ATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL 780 ATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL Sbjct: 721 ATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL 780 Query: 781 PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819 PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS Sbjct: 781 PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819 >gi|4557729 voltage-gated potassium channel, subfamily H, member 2 isoform a [Homo sapiens] Length = 1159 Score = 1598 bits (4138), Expect = 0.0 Identities = 783/784 (99%), Positives = 784/784 (100%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 +VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE Sbjct: 376 QVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 435 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK Sbjct: 436 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 495 Query: 156 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 215 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC Sbjct: 496 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 555 Query: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL Sbjct: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615 Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT Sbjct: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675 Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS Sbjct: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735 Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV Sbjct: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795 Query: 456 VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS 515 VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS Sbjct: 796 VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS 855 Query: 516 LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 575 LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA Sbjct: 856 LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 915 Query: 576 GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 635 GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME Sbjct: 916 GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 975 Query: 636 DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 695 DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR Sbjct: 976 DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 1035 Query: 696 GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL 755 GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL Sbjct: 1036 GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL 1095 Query: 756 PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS 815 PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS Sbjct: 1096 PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS 1155 Query: 816 DPGS 819 DPGS Sbjct: 1156 DPGS 1159 >gi|27886653 potassium voltage-gated channel, subfamily H, member 7 isoform 1 [Homo sapiens] Length = 1196 Score = 903 bits (2334), Expect = 0.0 Identities = 485/721 (67%), Positives = 546/721 (75%), Gaps = 35/721 (4%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 +VLSLGADVLPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL + Sbjct: 376 QVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLND 435 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 EE ECGY+C PL VVDLIVDIMFI+DILINFRTTYVN NEEVVS P +IA+HYFK Sbjct: 436 REE-QKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFK 494 Query: 156 GWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 212 GWFLIDMVAAIPFDLLIFGSGS+E LIGLLKTARLLRLVRVARKLDRYSEYGAAVL L Sbjct: 495 GWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLML 554 Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKY 271 LMC FALIAHWLACIWYAIGN+E+P++ +IGWL +LG QIGK YN S GPSIKDKY Sbjct: 555 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614 Query: 272 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA Sbjct: 615 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674 Query: 332 RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLH 391 RYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLH Sbjct: 675 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734 Query: 392 LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 451 LN++LLQ+CK FRGA+KGCLRALAMKFKTTHAPPGDTLVH GD+LTALYF+SRGSIEIL+ Sbjct: 735 LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794 Query: 452 GDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDH 511 D+VVAILGKNDIFGE ++LYA+PGKSN DVRALTYCDLHKI R+DLLEVLDMYPEFSDH Sbjct: 795 DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854 Query: 512 FWSSLEITFNLRDTNM---IPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSAL 568 F ++LE+TFNLR + + S + EG + R+RKLSF +K+ + Sbjct: 855 FLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSA 914 Query: 569 GPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPP 628 R + E S S S +DE P S P Sbjct: 915 DTIRHYQSSKRH------FEEKKSRSSSFISSIDDEQK----------PLFSGIVDSSPG 958 Query: 629 GGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAP---TPSLLNI 685 G+ D E++ P SG S + R ++ P P +PS L Sbjct: 959 IGKASGLDFEETV----PTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQR 1014 Query: 686 PL----SSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAV 741 + G+VE RLD LQ QLNRLE++++ D+ T+LQLLQ+Q T+VPPAYS V Sbjct: 1015 AAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMV 1074 Query: 742 T 742 T Sbjct: 1075 T 1075 >gi|13540549 potassium voltage-gated channel, subfamily H, member 6 isoform 1 [Homo sapiens] Length = 994 Score = 872 bits (2254), Expect = 0.0 Identities = 507/846 (59%), Positives = 577/846 (68%), Gaps = 89/846 (10%) Query: 7 KASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPF 66 ++S T + A V R ++ V Q VLSLGADVLPEYKLQAPRIHRWTILHYSPF Sbjct: 197 RSSSTTEIEIIAPHKVVERTQNVTEKVTQ-VLSLGADVLPEYKLQAPRIHRWTILHYSPF 255 Query: 67 KAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVD 126 KAVWDWLILLLVIYTAVFTPYSAAFLL + +E C Y C PL VVDLIVDIMF+VD Sbjct: 256 KAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA-CSYTCSPLTVVDLIVDIMFVVD 314 Query: 127 ILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGL 183 I+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVAAIPFDLLIF +GS+E LIGL Sbjct: 315 IVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGL 374 Query: 184 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 243 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGN+E+P+++ +I Sbjct: 375 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKI 434 Query: 244 GWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSI 302 GWL +LG Q+GK YN S GPS++DKYVTALYFTFSSLTSVGFGNVSPNTNSEK+FSI Sbjct: 435 GWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSI 494 Query: 303 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQ 362 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+EFIRFHQIPNPLRQRLEEYFQ Sbjct: 495 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQ 554 Query: 363 HAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTH 422 HAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC F GA KGCLRALA+KFKTTH Sbjct: 555 HAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTH 614 Query: 423 APPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDV 482 APPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGKNDIFGEP++L+A+PGKS+ DV Sbjct: 615 APPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADV 674 Query: 483 RALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDT-----NMIPGSPGSTEL 537 RALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFNLRD + +PGS + Sbjct: 675 RALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDH 734 Query: 538 EGGFSRQRKRKLSFRRRTDKDTEQPGEV---------SALGPG---RAGAGPSSRGRPGG 585 +G F +D + P E+ S LGPG GAGP + G P Sbjct: 735 QGFF------------LSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHPDA 782 Query: 586 --PWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLM--EDCEKSS 641 P S +SG PE ++ + P SP+ P E P PL E+ Sbjct: 783 APPLSISDASG-LWPELLQE-----------MPPRHSPQSPQEDPDCWPLKLGSRLEQLQ 830 Query: 642 DTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESR 701 N L S S++ SR Q + P +L P S+ + Sbjct: 831 AQMNRLESRVS--SDL------SRILQLLQKPMPQGHASYILEAPASN---------DLA 873 Query: 702 LDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLP 761 L + + RL Q P+Y + P ++SP +P L Sbjct: 874 LVPIASETTSPGPRLPQGFLPPAQ---------TPSYGDLDDCSPKHRNSSPRMP--HLA 922 Query: 762 TLTLDSLSQVSQFMACEEL--PPGAPELPQE------GPTRRLSLPGQLGALTSQ-PLHR 812 T +L+ S+ E L P +P P E GP SLP LG++ Q R Sbjct: 923 VATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFS-SLPEHLGSVPKQLDFQR 981 Query: 813 HGSDPG 818 HGSDPG Sbjct: 982 HGSDPG 987 >gi|26051271 voltage-gated potassium channel, subfamily H, member 2 isoform b [Homo sapiens] Length = 888 Score = 863 bits (2231), Expect = 0.0 Identities = 424/425 (99%), Positives = 425/425 (100%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 +VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE Sbjct: 376 QVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 435 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK Sbjct: 436 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 495 Query: 156 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 215 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC Sbjct: 496 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 555 Query: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL Sbjct: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615 Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT Sbjct: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675 Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS Sbjct: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735 Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV Sbjct: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795 Query: 456 VAILG 460 VAILG Sbjct: 796 VAILG 800 >gi|27886651 potassium voltage-gated channel, subfamily H, member 6 isoform 2 [Homo sapiens] Length = 905 Score = 759 bits (1960), Expect = 0.0 Identities = 397/543 (73%), Positives = 428/543 (78%), Gaps = 62/543 (11%) Query: 7 KASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPF 66 ++S T + A V R ++ V Q VLSLGADVLPEYKLQAPRIHRWTILHYSPF Sbjct: 197 RSSSTTEIEIIAPHKVVERTQNVTEKVTQ-VLSLGADVLPEYKLQAPRIHRWTILHYSPF 255 Query: 67 KAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVD 126 KAVWDWLILLLVIYTAVFTPYSAAFLL + +E C Y C PL VVDLIVDIMF+VD Sbjct: 256 KAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA-CSYTCSPLTVVDLIVDIMFVVD 314 Query: 127 ILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGL 183 I+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVAAIPFDLLIF +GS+E LIGL Sbjct: 315 IVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGL 374 Query: 184 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 243 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI Sbjct: 375 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI---------------- 418 Query: 244 GWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSIC 303 SLTSVGFGNVSPNTNSEK+FSIC Sbjct: 419 ------------------------------------CSLTSVGFGNVSPNTNSEKVFSIC 442 Query: 304 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQH 363 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+EFIRFHQIPNPLRQRLEEYFQH Sbjct: 443 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQH 502 Query: 364 AWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHA 423 AWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC F GA KGCLRALA+KFKTTHA Sbjct: 503 AWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHA 562 Query: 424 PPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVR 483 PPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGKNDIFGEP++L+A+PGKS+ DVR Sbjct: 563 PPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVR 622 Query: 484 ALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDT-----NMIPGSPGSTELE 538 ALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFNLRD + +PGS + + Sbjct: 623 ALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQ 682 Query: 539 GGF 541 G F Sbjct: 683 GFF 685 Score = 53.9 bits (128), Expect = 6e-07 Identities = 79/250 (31%), Positives = 103/250 (41%), Gaps = 71/250 (28%) Query: 619 SSPRP-PGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPA 677 SSPR PG + D SD PLS +S+ W + QE+P + Sbjct: 670 SSPRQAPGSQDHQGFFLSD--NQSDAAPPLS-----ISDASGLWPEL----LQEMPPRHS 718 Query: 678 PTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQM------ 731 P P P P + SRL+ LQ Q+NRLE+R+S+D++ +LQLLQ+ M Sbjct: 719 PQS-----PQEDPDCWPL-KLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHAS 772 Query: 732 -----------TLVPPAYSAVTTPGP-------GPTST----------------SPLLPV 757 LVP A S T+PGP P T SP +P Sbjct: 773 YILEAPASNDLALVPIA-SETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMP- 830 Query: 758 SPLPTLTLDSLSQVSQFMACEEL--PPGAPELPQE------GPTRRLSLPGQLGALTSQ- 808 L T +L+ S+ E L P +P P E GP SLP LG++ Q Sbjct: 831 -HLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFS-SLPEHLGSVPKQL 888 Query: 809 PLHRHGSDPG 818 RHGSDPG Sbjct: 889 DFQRHGSDPG 898 >gi|27886665 potassium voltage-gated channel, subfamily H, member 7 isoform 2 [Homo sapiens] Length = 732 Score = 592 bits (1527), Expect = e-169 Identities = 296/345 (85%), Positives = 315/345 (91%), Gaps = 5/345 (1%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 +VLSLGADVLPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL + Sbjct: 369 QVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLND 428 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 EE ECGY+C PL VVDLIVDIMFI+DILINFRTTYVN NEEVVS P +IA+HYFK Sbjct: 429 REE-QKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFK 487 Query: 156 GWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 212 GWFLIDMVAAIPFDLLIFGSGS+E LIGLLKTARLLRLVRVARKLDRYSEYGAAVL L Sbjct: 488 GWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLML 547 Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKY 271 LMC FALIAHWLACIWYAIGN+E+P++ +IGWL +LG QIGK YN S GPSIKDKY Sbjct: 548 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 607 Query: 272 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA Sbjct: 608 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 667 Query: 332 RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAV 376 RYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN V Sbjct: 668 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 712 >gi|6912446 potassium voltage-gated channel, subfamily H, member 4 [Homo sapiens] Length = 1017 Score = 478 bits (1231), Expect = e-135 Identities = 316/800 (39%), Positives = 437/800 (54%), Gaps = 77/800 (9%) Query: 45 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 104 +PEYK+ + R +LHYS KA+WD LILL Y AV PY+ F ++ P T Sbjct: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260 Query: 105 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 164 + V D+ V+++FI+DI++NFRTTYV+ + +V+S P I +HY WF ID++A Sbjct: 261 -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315 Query: 165 AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 223 A+PFDLL IF L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW Sbjct: 316 ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375 Query: 224 LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 280 +ACIWY IG E D IGWLH LG ++ PY + +GGPS + Y+ ALYFT S Sbjct: 376 MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435 Query: 281 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 340 SLTSVGFGNV NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YH++M + Sbjct: 436 SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495 Query: 341 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 400 ++FIR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HLNR +LQ Sbjct: 496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554 Query: 401 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 460 F A++GCLRAL++ KT+ PG+ L+ GD L A Y++ GS+E+LR ++V+AILG Sbjct: 555 PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614 Query: 461 KNDIFGEPL-------NLYARPG---KSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSD 510 K D+ G + L A P K++ DV+ALTYC L ++ L EVL +YPE+ Sbjct: 615 KGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGA 674 Query: 511 HFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSR-QRKRKLSFRRRTDKDTEQPGEVSA 567 F + L ++TFNLR GS S G SR R +LS R + + + Sbjct: 675 AFRAGLPRDLTFNLRQ-----GSDTS-----GLSRFSRSPRLSQPRSESLGSSSDKTLPS 724 Query: 568 LGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESS-----EDEGPGRS---SSPLRLVPFS 619 + +GA P RP P P+ P+ P S +E P S SSP L P Sbjct: 725 ITEAESGAEPGGGPRPRRPL-LLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSL 782 Query: 620 SPRPPGE----PPGGEPLMEDCEKSSDTCNPLSGAF----------SGVSNIFSFWGDSR 665 SP G+ P G P K P G F G+ + S ++ Sbjct: 783 SPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGS-TAEAP 841 Query: 666 GRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQ 725 ++ P P P G RP ++ S + ++ ++ RL +S V Q Sbjct: 842 SFRFSRRPELPRPRSQ-----APPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQ 896 Query: 726 LLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAP 785 L R++ + A P PG + S P P P L LS C PP P Sbjct: 897 -LSRELRHIMGLLQARLGP-PGHPAGSAWTPDPPCPQLRPPCLS------PCASRPP--P 946 Query: 786 ELPQEGPTRRLSLPGQLGAL 805 L Q+ + P +G + Sbjct: 947 SL-QDTTLAEVHCPASVGTM 965 >gi|27886667 potassium voltage-gated channel, subfamily H, member 8 [Homo sapiens] Length = 1107 Score = 476 bits (1226), Expect = e-134 Identities = 290/725 (40%), Positives = 415/725 (57%), Gaps = 52/725 (7%) Query: 46 PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATEC 105 PEYK+ + ++ +LH+S FKA WDWLILL Y AV PY+ F+ + +T Sbjct: 200 PEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST-- 257 Query: 106 GYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAA 165 V D+ V+I+FI+DI++NFRTTYV+ + +V+ I +HY WF+ID++AA Sbjct: 258 -------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAA 310 Query: 166 IPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL 224 +PFDLL F L+ LLKT RLLRL+R+ +KLDRYS++ VL LLM FAL+AHW+ Sbjct: 311 LPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWM 370 Query: 225 ACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSIKDKYVTALYFTFS 280 ACIWY IG ME+ + +GWLH LG ++ PY ++ LGGPSI+ Y+ ALYFT S Sbjct: 371 ACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLS 430 Query: 281 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 340 SLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YHT+ + Sbjct: 431 SLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDL 490 Query: 341 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 400 ++FIR H +P L+QR+ EYFQ WS NGID N +LK FP+ L++DI +HLN+ +LQ Sbjct: 491 KDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-L 549 Query: 401 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 460 F A++GCLR+L++ KT+ PG+ L+ GD L A+YF+ GS+E+L+ +V+AILG Sbjct: 550 SLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILG 609 Query: 461 KNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EI 518 K D+ G L++ + K+N DV+ALTYCDL I L EVLD+YPE++ F + ++ Sbjct: 610 KGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDL 669 Query: 519 TFNLRD-------TNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPG 571 T+NLR+ + + S S G KR S +++ E E + Sbjct: 670 TYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSP 729 Query: 572 RAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGE--PPG 629 G SSR + G G S + + P SP+R+ +SP+ E PP Sbjct: 730 ICTRGSSSRNKKVG--SNKAYLGLSLKQLASGTVP--FHSPIRVSRSNSPKTKQEIDPPN 785 Query: 630 GEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSS 689 E K + +G I G G +E + + + P S Sbjct: 786 HNKRKEKNLKLQLSTLNNAGPPDLSPRIVD--GIEDGNSSEESQTFDFGSERIRSEPRIS 843 Query: 690 PGRRPRGDVE-------SRLDALQRQLNRLE----------TRLSADMATVLQLLQRQMT 732 P P GD E + + ++Q+N+L ++L DM V+QLL+ ++ Sbjct: 844 P---PLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS 900 Query: 733 LVPPA 737 P+ Sbjct: 901 PQQPS 905 >gi|4504831 potassium voltage-gated channel, subfamily H, member 1 isoform 2 [Homo sapiens] Length = 962 Score = 473 bits (1216), Expect = e-133 Identities = 244/525 (46%), Positives = 340/525 (64%), Gaps = 32/525 (6%) Query: 14 LRPRAQKGR-VRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDW 72 L P QKG V + R++ EVL LG+D+LP+YK +AP+ ILHY FK WDW Sbjct: 168 LAPSVQKGENVHKHSRLA-----EVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDW 222 Query: 73 LILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 132 +IL+L YTA+ PY+ +F ++ VVD IVD++F+VDI++NF Sbjct: 223 IILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDIVLNFH 270 Query: 133 TTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTAR 188 TT+V EV+S P I ++Y K WF+ID+++ +P+D++ G L LK R Sbjct: 271 TTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVR 330 Query: 189 LLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI----G 244 LLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E D++ Sbjct: 331 LLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNS 390 Query: 245 WLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 298 WL+ L IG PY +G G GPS Y+++LYFT +SLTSVGFGN++P+T+ EK Sbjct: 391 WLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK 450 Query: 299 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLE 358 IF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH + VR+F++ +Q+P L +R+ Sbjct: 451 IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVM 510 Query: 359 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKF 418 +Y WS + GID VL+ P+ ++ADIC+HLNR + + FR A+ GCLRALAM+F Sbjct: 511 DYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEF 570 Query: 419 KTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKS 478 +T H PGD + HAG+ + +L F+ GS+E+++ D VVAILGK D+FG+ A +S Sbjct: 571 QTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQS 630 Query: 479 NGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 523 +VRALTYCDLH I RD L +VL+ Y FS F +L +T+NLR Sbjct: 631 CANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675 >gi|27437001 potassium voltage-gated channel, subfamily H, member 1 isoform 1 [Homo sapiens] Length = 989 Score = 462 bits (1189), Expect = e-130 Identities = 244/552 (44%), Positives = 340/552 (61%), Gaps = 59/552 (10%) Query: 14 LRPRAQKGR-VRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDW 72 L P QKG V + R++ EVL LG+D+LP+YK +AP+ ILHY FK WDW Sbjct: 168 LAPSVQKGENVHKHSRLA-----EVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDW 222 Query: 73 LILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 132 +IL+L YTA+ PY+ +F ++ VVD IVD++F+VDI++NF Sbjct: 223 IILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDIVLNFH 270 Query: 133 TTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF------------------- 173 TT+V EV+S P I ++Y K WF+ID+++ +P+D++ Sbjct: 271 TTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGF 330 Query: 174 ------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 221 G L LK RLLRL RVARKLD Y EYGAAVL LL+C F L A Sbjct: 331 ADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAA 390 Query: 222 HWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPSIKDKY 271 HW+ACIWY+IG+ E D++ WL+ L IG PY +G G GPS Y Sbjct: 391 HWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVY 450 Query: 272 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331 +++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T Sbjct: 451 ISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTN 510 Query: 332 RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLH 391 RYH + VR+F++ +Q+P L +R+ +Y WS + GID VL+ P+ ++ADIC+H Sbjct: 511 RYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVH 570 Query: 392 LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 451 LNR + + FR A+ GCLRALAM+F+T H PGD + HAG+ + +L F+ GS+E+++ Sbjct: 571 LNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ 630 Query: 452 GDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDH 511 D VVAILGK D+FG+ A +S +VRALTYCDLH I RD L +VL+ Y FS Sbjct: 631 DDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHS 690 Query: 512 FWSSLEITFNLR 523 F +L +T+NLR Sbjct: 691 FSRNLILTYNLR 702 >gi|22024390 potassium voltage-gated channel, subfamily H, member 5 isoform 1 [Homo sapiens] Length = 988 Score = 461 bits (1187), Expect = e-130 Identities = 234/501 (46%), Positives = 329/501 (65%), Gaps = 25/501 (4%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 EVL LG+D+LP+YK +AP+ ILHY FK WDW+IL+L YTA+ PY+ +F K+ Sbjct: 183 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 242 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 V+D +VD++F+VDI++NF TT+V EV+S P I ++Y K Sbjct: 243 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 290 Query: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211 WF+ID+++ +P+D++ G L LK RLLRL RVARKLD Y EYGAAVL Sbjct: 291 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 350 Query: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262 LL+C F L+AHWLACIWY+IG+ E + + I WL+ L IG PY S+G+ Sbjct: 351 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 410 Query: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322 GGPS YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Sbjct: 411 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 470 Query: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382 Q++Y+ T RYH + VR+F++ +Q+P L +R+ +Y WS + GID VL P+ Sbjct: 471 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 530 Query: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442 ++ADIC+HLNR + FR A+ GCLRALA++F+T H PGD + HAG+ + AL F+ Sbjct: 531 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 590 Query: 443 SRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 502 GS+E+++ D VVAILGK D+FG+ + +VRALTYCDLH I R+ LL+VL Sbjct: 591 VSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVL 650 Query: 503 DMYPEFSDHFWSSLEITFNLR 523 D Y F++ F +L +T NLR Sbjct: 651 DFYTAFANSFSRNLTLTCNLR 671 >gi|27886648 potassium voltage-gated channel, subfamily H, member 5 isoform 2 [Homo sapiens] Length = 624 Score = 461 bits (1187), Expect = e-130 Identities = 234/501 (46%), Positives = 329/501 (65%), Gaps = 25/501 (4%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 EVL LG+D+LP+YK +AP+ ILHY FK WDW+IL+L YTA+ PY+ +F K+ Sbjct: 125 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 184 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 V+D +VD++F+VDI++NF TT+V EV+S P I ++Y K Sbjct: 185 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 232 Query: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211 WF+ID+++ +P+D++ G L LK RLLRL RVARKLD Y EYGAAVL Sbjct: 233 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 292 Query: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262 LL+C F L+AHWLACIWY+IG+ E + + I WL+ L IG PY S+G+ Sbjct: 293 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 352 Query: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322 GGPS YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Sbjct: 353 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 412 Query: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382 Q++Y+ T RYH + VR+F++ +Q+P L +R+ +Y WS + GID VL P+ Sbjct: 413 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 472 Query: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442 ++ADIC+HLNR + FR A+ GCLRALA++F+T H PGD + HAG+ + AL F+ Sbjct: 473 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 532 Query: 443 SRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 502 GS+E+++ D VVAILGK D+FG+ + +VRALTYCDLH I R+ LL+VL Sbjct: 533 VSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVL 592 Query: 503 DMYPEFSDHFWSSLEITFNLR 523 D Y F++ F +L +T NLR Sbjct: 593 DFYTAFANSFSRNLTLTCNLR 613 >gi|38569493 potassium voltage-gated channel, subfamily H (eag-related), member 3 [Homo sapiens] Length = 1083 Score = 448 bits (1153), Expect = e-126 Identities = 300/782 (38%), Positives = 408/782 (52%), Gaps = 119/782 (15%) Query: 45 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 104 LPEYK+ A R + +LH +A WD ILL +Y AV PYS A E Sbjct: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253 Query: 105 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 164 A P +V DL V+++FI+DI++NFRTT+V+ + +VV P I +HY WFL+D++A Sbjct: 254 PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313 Query: 165 AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 217 A+PFDLL FG+ LLKT RLLRL+R+ +LDRYS+Y A VL LLM F Sbjct: 314 ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367 Query: 218 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 261 AL+AHW+AC+W+ IG E +S IGWL L ++ PY NSSG Sbjct: 368 ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427 Query: 262 ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 306 LGGPS++ Y+T+LYF SSLTSVGFGNVS NT++EKIFSIC ML Sbjct: 428 NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487 Query: 307 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 366 IG+LM+A +FGNV+AIIQR+Y+ YH++ +R++IR H+IP PL+QR+ EYFQ W+ Sbjct: 488 IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547 Query: 367 YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 426 NGID +L+ P+ L+ADI +HL++ +LQ F A++GCLRAL++ + PG Sbjct: 548 VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606 Query: 427 DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALT 486 + L+H GD L ALYF+ GS+E+L+G V+AILGK D+ G L + K+N DV+ LT Sbjct: 607 EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLT 666 Query: 487 YCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSRQ 544 YC L + L + L +YPEF+ F L E+++NL GS E++ Sbjct: 667 YCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL------GAGGGSAEVDTSSLSG 720 Query: 545 RKRKLSFRRRTDKDTEQ------------------PGEVSA------LGPGRAGAGP--S 578 +S + D EQ PG S+ L P R P Sbjct: 721 DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780 Query: 579 SRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCE 638 RGRPG +GPS+P R+ LRL P PP P +++ E Sbjct: 781 GRGRPGRAGALKAEAGPSAPP--------RALEGLRLPPMPWNVPPDLSP---RVVDGIE 829 Query: 639 KSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDV 698 + P FSF G + P P P LL +P P D Sbjct: 830 DGCGSDQPK----------FSFRVGQSGPECSSSP-SPGPESGLLTVP-HGPSEARNTDT 877 Query: 699 ESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTP-----GPGPTSTSP 753 LD L++ + L ++ M LQ L++ + LV + P GP P STS Sbjct: 878 ---LDKLRQAVTELSEQV-LQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSG 933 Query: 754 LL 755 LL Sbjct: 934 LL 935 >gi|27886646 potassium voltage-gated channel, subfamily H, member 5 isoform 3 [Homo sapiens] Length = 611 Score = 408 bits (1048), Expect = e-113 Identities = 204/437 (46%), Positives = 289/437 (66%), Gaps = 25/437 (5%) Query: 36 EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95 EVL LG+D+LP+YK +AP+ ILHY FK WDW+IL+L YTA+ PY+ +F K+ Sbjct: 183 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 242 Query: 96 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155 V+D +VD++F+VDI++NF TT+V EV+S P I ++Y K Sbjct: 243 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 290 Query: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211 WF+ID+++ +P+D++ G L LK RLLRL RVARKLD Y EYGAAVL Sbjct: 291 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 350 Query: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262 LL+C F L+AHWLACIWY+IG+ E + + I WL+ L IG PY S+G+ Sbjct: 351 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 410 Query: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322 GGPS YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Sbjct: 411 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 470 Query: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382 Q++Y+ T RYH + VR+F++ +Q+P L +R+ +Y WS + GID VL P+ Sbjct: 471 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 530 Query: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442 ++ADIC+HLNR + FR A+ GCLRALA++F+T H PGD + HAG+ + AL F+ Sbjct: 531 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 590 Query: 443 SRGSIEILRGDVVVAIL 459 GS+E+++ D VVAIL Sbjct: 591 VSGSLEVIQDDEVVAIL 607 >gi|116325989 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 [Homo sapiens] Length = 890 Score = 175 bits (443), Expect = 2e-43 Identities = 176/783 (22%), Positives = 318/783 (40%), Gaps = 107/783 (13%) Query: 58 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117 W I YS F+ WD ++L++++ V P F ++T P + ++ Sbjct: 133 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTT------------PWIIFNV 180 Query: 118 IVDIMFIVDILINFRTTYVNANE-EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 173 D +F++D+++NFRT VN + E++ P I ++Y K WF++D +++IP D + Sbjct: 181 ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE 240 Query: 174 -GSGSE--------------ELIGLLKTARLLRLVRVARKLDR-----YSEYGAAV-LFL 212 G SE +++ LL+ RL RL+R + + Y A V +F Sbjct: 241 KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN 300 Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272 L+ L+ HW C+ + + ++ D + + D GK Y+ Sbjct: 301 LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSY------------- 347 Query: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332 AL+ S + +G+G +P + S+ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 348 -ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQ 406 Query: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392 Y + +V +++ FH++P +RQ++ +Y++H + D +L + L+ +I Sbjct: 407 YQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFN 465 Query: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452 R L+ F A + A+ K + PGD ++ G + +YFI G ++ Sbjct: 466 CRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK 525 Query: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 512 L FGE L G+ VRA TYC L+ + D+ EVL+ YP F Sbjct: 526 SSKEMKLTDGSYFGEICLL--TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 583 Query: 513 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQP------GE 564 + +++ + N I +L G F+ Q L + D++ Q + Sbjct: 584 ETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQ 643 Query: 565 VSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPP 624 ++ L + P+SR R P P +++ L SP P Sbjct: 644 MTTLNSTSSTTTPTSRMRTQSP-------------------PVYTATSLSHSNLHSPSPS 684 Query: 625 GEPPGGEPLMEDCEKSSDTCNP------LSGAF---SGVSNIFSFWGDSRGRQYQE---- 671 + P ++ C ++ C+P + F S ++ S +Q Q+ Sbjct: 685 TQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPP 744 Query: 672 --LPRCPAPTPSLLNIPLSSPG-RRPRGDVESRLDALQR-QLNRLETRLSADMATVLQLL 727 P+ P+P P +PG P+ +V AL L R LSA ++ + Sbjct: 745 QTQPQQPSPQP-------QTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEV 797 Query: 728 QRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPP--GAP 785 ++ P P P + P + T+ + + M+ +PP G P Sbjct: 798 STLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVP 857 Query: 786 ELP 788 P Sbjct: 858 PAP 860 >gi|4885407 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Homo sapiens] Length = 1203 Score = 174 bits (442), Expect = 2e-43 Identities = 124/474 (26%), Positives = 214/474 (45%), Gaps = 54/474 (11%) Query: 58 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117 W I YS F+ WD +LLL++ + P F E P V ++ Sbjct: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300 Query: 118 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 176 + D F++D+++NFRT V N E++ P RI + Y K WF++D +++IP D + Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 Query: 177 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 212 + + KTAR LR+VR + +L R Y +AV+ + Sbjct: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272 L+ L+ HW C+ + + ++ D + + + + GK Y+ Sbjct: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467 Query: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526 Query: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392 Y + +V +++ FH++P RQR+ +Y++H + D ++L E L+ +I Sbjct: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585 Query: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452 R L+ F A + ++ K + PGD ++ G + +YFI G + +L Sbjct: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645 Query: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 506 L FGE + L R G+ VRA TYC L+ + D+ EVL+ YP Sbjct: 646 GNKETKLADGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYP 697 Score = 35.0 bits (79), Expect = 0.28 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 22/102 (21%) Query: 563 GEVSALGPGRAGAGPSSRGRPGGPWGESP------SSGPSSPE--------SSEDEGPGR 608 G +++LG G+G + G G +S + G +SP ++E E PG Sbjct: 98 GSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGA 157 Query: 609 SSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSS-DTCNPLSG 649 S+ P +SP PP +PP +P CE+ S DT + G Sbjct: 158 SAQPA-----ASPPPPQQPP--QPASASCEQPSVDTAIKVEG 192 Score = 30.4 bits (67), Expect = 6.9 Identities = 24/72 (33%), Positives = 28/72 (38%), Gaps = 4/72 (5%) Query: 561 QPGEVSALGPGRAGAGPSSRGRPGGPWGESP----SSGPSSPESSEDEGPGRSSSPLRLV 616 QPG S + A P +RG G P P S PSS + PG S L Sbjct: 930 QPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATG 989 Query: 617 PFSSPRPPGEPP 628 P S+P P P Sbjct: 990 PLSTPETPPRQP 1001 Score = 30.4 bits (67), Expect = 6.9 Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 4/63 (6%) Query: 570 PGRAGAGPS--SRGRPGGPWGESPSSGPSSPES-SEDEGPGRSSSPLRLVPFSSPRPPGE 626 PG+ G P S G GP +P + P PE S G +SP+ P PPG Sbjct: 972 PGQLGQPPGELSLGLATGPLS-TPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGH 1030 Query: 627 PPG 629 PG Sbjct: 1031 SPG 1033 Score = 30.0 bits (66), Expect = 9.1 Identities = 25/84 (29%), Positives = 33/84 (39%), Gaps = 11/84 (13%) Query: 560 EQPGEVS-ALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEG----PGRSSSPLR 614 + PGE+S L G + +P P + +SG +SP G PG S P R Sbjct: 977 QPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPR 1036 Query: 615 LVPFSSPRPPGE------PPGGEP 632 P + PR G PP P Sbjct: 1037 TFPSAPPRASGSHGSLLLPPASSP 1060 >gi|156071470 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 [Homo sapiens] Length = 889 Score = 173 bits (438), Expect = 7e-43 Identities = 161/659 (24%), Positives = 271/659 (41%), Gaps = 103/659 (15%) Query: 58 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117 W I YS F+ WD+ +LL ++ + P F ET P V ++ Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249 Query: 118 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 173 + D F++D+++NFRT V N E++ P +I Y + WF++D V++IP D + Sbjct: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309 Query: 174 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 216 G SE +L RLLRL R+ R + ++ E Y A + +C Sbjct: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369 Query: 217 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272 L+ HW C+ + + ++ R W+ + +G+ S + Y Sbjct: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415 Query: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332 AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475 Query: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392 Y + +V +++ FH++P RQ++ +Y++H + D +++L L+ +I Sbjct: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534 Query: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452 R L+ F A + A+ K K PGD ++ G + +YFI G + +L Sbjct: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 594 Query: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 512 L FGE + L R G+ VRA TYC L+ + D+ EVL+ YP F Sbjct: 595 GNKEMKLSDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652 Query: 513 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQPGEVS---- 566 + +++ + N I +L G F+ Q + + D++ Q E+ Sbjct: 653 ETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVG 712 Query: 567 ---------------------------------ALGPGRAGAGPSSRGRPGGPWGESPSS 593 +GP G+ R P GP + S Sbjct: 713 LFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASP 772 Query: 594 GPSSPESSEDEGPGRSSSPLRLVPFSSPRP--PGEPPGGEPLMEDCEKSSDTCNPLSGA 650 GP P S PG +SP P +SP P P G L + S PLS + Sbjct: 773 GPPPPASP----PGAPASP--RAPRTSPYGGLPAAPLAGPAL--PARRLSRASRPLSAS 823 Score = 31.2 bits (69), Expect = 4.1 Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 13/75 (17%) Query: 570 PGRAGAGPSSRGRPGGPWGE-SPSSGPSSPES------------SEDEGPGRSSSPLRLV 616 PG GA +++G P G G P P+ PE GP P Sbjct: 85 PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEA 144 Query: 617 PFSSPRPPGEPPGGE 631 P GEP G + Sbjct: 145 GSEEAGPAGEPRGSQ 159 Score = 30.4 bits (67), Expect = 6.9 Identities = 29/109 (26%), Positives = 39/109 (35%), Gaps = 24/109 (22%) Query: 735 PPAYSAVTTPGPGPTSTSPLLPVSPL-----------------PTLTLDSLSQVSQFMAC 777 P A +PGP P ++ P P SP P L LS+ S+ ++ Sbjct: 763 PGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSA 822 Query: 778 EE--LPPGAP-----ELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819 + LP GAP P T RL A P R + PG+ Sbjct: 823 SQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGA 871 Score = 30.0 bits (66), Expect = 9.1 Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 9/58 (15%) Query: 581 GRPGGPWGESPSSG-----PSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPL 633 GRPG G +P+ G P +P + P + P P P PP PP E L Sbjct: 8 GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP----PGPGPAPPQHPPRAEAL 61 >gi|38327037 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 [Homo sapiens] Length = 774 Score = 172 bits (436), Expect = 1e-42 Identities = 137/536 (25%), Positives = 232/536 (43%), Gaps = 62/536 (11%) Query: 4 PAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYK---LQAPRIHR--- 57 P T A P + G + + +L+ V V +K ++ R+ Sbjct: 24 PVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGA 83 Query: 58 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117 W I YS F+ WD ++LLL++ + P F EE P P V ++ Sbjct: 84 WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131 Query: 118 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 176 + D F++D+++NFRT V E++ P I Y + WFL+D++++IP D + Sbjct: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191 Query: 177 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 210 E + + KTAR LR+VR + +L R Y +AV + Sbjct: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251 Query: 211 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 270 F L+ L+ HW C+ + + ++ D + H + G+ Y+ Sbjct: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300 Query: 271 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 330 AL+ S + +G+G +P + ++ M++G+ YA G+ +A+IQ L S Sbjct: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357 Query: 331 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 390 +Y + +V +++ FH++P RQR+ EY++H + D ++L E L+ +I Sbjct: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416 Query: 391 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 450 R L+ H F A + A+ K + PGD +V G + +YFI G + +L Sbjct: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476 Query: 451 RGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 506 L FGE + L R G+ VRA TYC L+ + D VL+ +P Sbjct: 477 ARGARDTRLTDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDHFNAVLEEFP 530 >gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [Homo sapiens] Length = 676 Score = 157 bits (398), Expect = 3e-38 Identities = 110/410 (26%), Positives = 203/410 (49%), Gaps = 37/410 (9%) Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172 V+D D+++++D+L+ RT ++ +VS R+ HY F +D+++ +P DL Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245 Query: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223 G+ ++ RLL+ R+ DR G VL++L +I HW Sbjct: 246 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 298 Query: 224 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 283 ACI++AI DS W++ I P + + KY+ +LY++ +LT Sbjct: 299 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 346 Query: 284 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 343 ++G P + E +F + L+G L++A+I GNV ++I + + A + ++ ++++ Sbjct: 347 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405 Query: 344 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 403 ++F ++ L R+ +F + W+ +D VLK P+ L+A+I ++++ L+ + F Sbjct: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465 Query: 404 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGK 461 + G L L +K + T PGD + GD+ +Y I+ G + ++ D V +L Sbjct: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525 Query: 462 NDIFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 FGE L + KS ++R++ Y DL + +DDL+E L YPE Sbjct: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575 >gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo sapiens] Length = 694 Score = 157 bits (398), Expect = 3e-38 Identities = 110/410 (26%), Positives = 203/410 (49%), Gaps = 37/410 (9%) Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172 V+D D+++++D+L+ RT ++ +VS R+ HY F +D+++ +P DL Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263 Query: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223 G+ ++ RLL+ R+ DR G VL++L +I HW Sbjct: 264 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 316 Query: 224 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 283 ACI++AI DS W++ I P + + KY+ +LY++ +LT Sbjct: 317 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 364 Query: 284 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 343 ++G P + E +F + L+G L++A+I GNV ++I + + A + ++ ++++ Sbjct: 365 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423 Query: 344 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 403 ++F ++ L R+ +F + W+ +D VLK P+ L+A+I ++++ L+ + F Sbjct: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 483 Query: 404 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGK 461 + G L L +K + T PGD + GD+ +Y I+ G + ++ D V +L Sbjct: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543 Query: 462 NDIFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 FGE L + KS ++R++ Y DL + +DDL+E L YPE Sbjct: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593 >gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [Homo sapiens] Length = 759 Score = 148 bits (373), Expect = 2e-35 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%) Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 173 ++D + DI++++D+ + RT Y+ V I + F +D+++ IP DLL F Sbjct: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330 Query: 174 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 231 G + I L + R R+ ++ + + Y + L+ +I HW AC++Y+I Sbjct: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390 Query: 232 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 291 D+ W++ N G + KYV +LY++ +LT++G Sbjct: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437 Query: 292 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 351 P +SE +F + LIG L++A+I GN+ ++I + + A + ++ +++++ F + Sbjct: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497 Query: 352 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 411 + +R+ ++F + W+ +D VLK P+ L+A+I ++++ L+ + F G L Sbjct: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557 Query: 412 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 469 L +K + PGD + GD+ +Y I G + ++ D V +L FGE Sbjct: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617 Query: 470 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 L + K+ +++++ Y DL + +DDL+E L YP+ Sbjct: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 659 >gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo sapiens] Length = 690 Score = 148 bits (373), Expect = 2e-35 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%) Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 173 ++D + DI++++D+ + RT Y+ V I + F +D+++ IP DLL F Sbjct: 202 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 261 Query: 174 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 231 G + I L + R R+ ++ + + Y + L+ +I HW AC++Y+I Sbjct: 262 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 321 Query: 232 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 291 D+ W++ N G + KYV +LY++ +LT++G Sbjct: 322 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 368 Query: 292 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 351 P +SE +F + LIG L++A+I GN+ ++I + + A + ++ +++++ F + Sbjct: 369 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 428 Query: 352 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 411 + +R+ ++F + W+ +D VLK P+ L+A+I ++++ L+ + F G L Sbjct: 429 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 488 Query: 412 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 469 L +K + PGD + GD+ +Y I G + ++ D V +L FGE Sbjct: 489 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 548 Query: 470 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 L + K+ +++++ Y DL + +DDL+E L YP+ Sbjct: 549 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 590 >gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] Length = 664 Score = 140 bits (352), Expect = 6e-33 Identities = 107/418 (25%), Positives = 194/418 (46%), Gaps = 53/418 (12%) Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 172 V+D + D+++I D+ I RT ++ +V ++ +Y F +D+ + IP DL+ Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235 Query: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223 F ++ RLL R+ DR VL++L+ I HW Sbjct: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288 Query: 224 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKD--------KYVTAL 275 ACI+YAI +D+ W++ P+I D +Y+ L Sbjct: 289 NACIYYAISKSIGFGVDT---WVY-----------------PNITDPEYGYLAREYIYCL 328 Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335 Y++ +LT++G P + E +F I LIG L++A+I GNV ++I + + A + Sbjct: 329 YWSTLTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQA 387 Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395 ++ V+ +++F ++ + ++ +F + W+ +D +LK P L+A+I ++++ S Sbjct: 388 KIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLS 447 Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455 L+ + F G L L +K + PGD + GD+ +Y I G + ++ D V Sbjct: 448 TLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGV 507 Query: 456 V--AILGKNDIFGEPLNLYARPGK----SNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 A+L FGE L + K ++R+L Y DL + +DDL+E + YP+ Sbjct: 508 TQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565 >gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] Length = 575 Score = 133 bits (335), Expect = 6e-31 Identities = 100/419 (23%), Positives = 201/419 (47%), Gaps = 30/419 (7%) Query: 101 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 159 P + GY L V+D D+++++D+++ F T ++ VV GRI+ Y + W F Sbjct: 59 PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116 Query: 160 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 215 +D+ + +P D++ G L+ R LR R+ DR A + LM Sbjct: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174 Query: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275 ++ HW +C+++A+ D+ W++ + + G ++ +Y+ + Sbjct: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222 Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335 YF+ LT+VG P E +F + L+ + +A+I G++S++I + + A ++ Sbjct: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281 Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395 V+++++ + L +R+ +++QH + A+L+ PE L+A++ + ++ S Sbjct: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341 Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455 L + F+ L L +K + PG+ + GD+ +Y I G + ++ D + Sbjct: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401 Query: 456 V--AILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE 507 A+LG FGE +++ G +G ++++L Y DL + ++DL EVL YP+ Sbjct: 402 TQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459 >gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo sapiens] Length = 1251 Score = 98.2 bits (243), Expect = 3e-20 Identities = 80/404 (19%), Positives = 185/404 (45%), Gaps = 35/404 (8%) Query: 114 VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 171 ++D + D+++ +DI + R +V + +++ + +Y K F +D+++ +P D L Sbjct: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751 Query: 172 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 228 G L+ L + + + +L+ S A ++ ++ T A + + L +C++ Sbjct: 752 YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809 Query: 229 YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 288 Y + +G H + D +G + Y+ YF +L ++G G Sbjct: 810 YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848 Query: 289 NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 348 P T E +F + G ++ + G + ++ +G Y + M +++ F++ Sbjct: 849 LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908 Query: 349 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 408 IP ++ R++ ++++ W +D + ++ P+ ++ D+ + +N +++ F+G + Sbjct: 909 IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968 Query: 409 GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIF 465 + + + ++ P D + G++ +Y I G +++L G V+ L +F Sbjct: 969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028 Query: 466 GEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 GE ++L A G + +V A + +L + + DL E+L YPE Sbjct: 1029 GE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071 >gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] Length = 809 Score = 94.7 bits (234), Expect = 3e-19 Identities = 84/402 (20%), Positives = 171/402 (42%), Gaps = 31/402 (7%) Query: 114 VVDLIVDIMFIVDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 171 + D+I DI+++ D+L I R +V + +V + HY F +D+ + IPFD+ Sbjct: 255 IADIICDIIYLYDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDIC 313 Query: 172 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYA 230 G + + + L+ + + + L I H AC++Y Sbjct: 314 YLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYW 373 Query: 231 IGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNV 290 N E W+ Y+ G ++Y+ Y+ +L ++G G Sbjct: 374 ASNYEGI---GTTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLP 412 Query: 291 SPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIP 350 P T E +F + G +++S+ G + +I + + M ++ + IP Sbjct: 413 EPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIP 472 Query: 351 NPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGC 410 +++R+ ++++ W +D + +LK P +Q + + +N S++ F+G Sbjct: 473 KLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQM 532 Query: 411 LRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIFGE 467 + + ++ K+ PGD + G++ +Y I G +++L G V+ L +FGE Sbjct: 533 IYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE 592 Query: 468 PLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507 ++L A G + +V A + +L + + L E+L YP+ Sbjct: 593 -ISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPD 633 >gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] Length = 1243 Score = 48.1 bits (113), Expect = 3e-05 Identities = 61/222 (27%), Positives = 82/222 (36%), Gaps = 27/222 (12%) Query: 592 SSGPSSPESSEDE-GPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGA 650 SS P +P S + PG SP + P +SP P P+ S+ + +P S Sbjct: 804 SSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVS-SNPSPHPTSSP 862 Query: 651 FSGVSNIFSFWGDSRGRQYQELPRCPAPT--PSLLNIPLSSPGRRPRGDVESRLDALQRQ 708 S+ F + LP PT P+ + LSSP P S Sbjct: 863 LPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAP 922 Query: 709 LNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTL--- 765 L L + S + TV Q L +P PG S SP P SPLP+L L Sbjct: 923 LLSLASAFSLAVMTVAQSL--------------LSPSPGLLSQSPPAPPSPLPSLPLPPP 968 Query: 766 ------DSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQ 801 +S S + + E PP A LP E +S G+ Sbjct: 969 VAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGK 1010 >gi|5031767 heat shock transcription factor 1 [Homo sapiens] Length = 529 Score = 45.8 bits (107), Expect = 2e-04 Identities = 63/236 (26%), Positives = 92/236 (38%), Gaps = 33/236 (13%) Query: 590 SPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEP------PGGEPLMEDCEKSSDT 643 +P+S +SP S DE P SSSPL V P PP P PG ++ + Sbjct: 272 APASPMASPGGSIDERP-LSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTAL 330 Query: 644 CNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLD 703 + + + D+RG E R P+P P+ S + ++ LD Sbjct: 331 IDSILRESEPAPASVTALTDARGHTDTE-GRPPSPPPTSTPEKCLSVACLDKNELSDHLD 389 Query: 704 ALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTL 763 A+ L+ L+T LS+ +S T+ S S +P LP L Sbjct: 390 AMDSNLDNLQTMLSSH-----------------GFSVDTSALLDLFSPSVTVPDMSLPDL 432 Query: 764 TLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819 SL+ + + ++ +E PP PE P QL T+QPL DPGS Sbjct: 433 D-SSLASIQELLSPQE-PPRPPEAENSSP----DSGKQLVHYTAQPLFL--LDPGS 480 >gi|58530876 melanoma antigen family C, 1 [Homo sapiens] Length = 1142 Score = 43.9 bits (102), Expect = 6e-04 Identities = 67/255 (26%), Positives = 97/255 (38%), Gaps = 56/255 (21%) Query: 590 SPSSGPSS-PESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLM--EDCEKSSDTCNP 646 +PSS P S PESS+ G SPL S PP PL E + D+ +P Sbjct: 636 TPSSLPQSFPESSQSPPEGPVQSPLH----SPQSPPEGMHSQSPLQSPESAPEGEDSLSP 691 Query: 647 LS---GAFSGVSNIFSF--------WGDS-----------RGRQYQELPRCPAP---TPS 681 L G ++ S W DS +G +Q + P + + Sbjct: 692 LQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSST 751 Query: 682 LLNIPLS---SPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAY 738 L++P S SP P G +S LQR ++ S +A++LQ ++ Sbjct: 752 SLSLPQSFPESPQSPPEGPAQS---PLQRPVSSF---FSYTLASLLQ----------SSH 795 Query: 739 SAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQ---VSQF--MACEELPPGAPELPQEGPT 793 + +P GP + PVS P+ T SLSQ VS F L +PE P + P Sbjct: 796 ESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPV 855 Query: 794 RRLSLPGQLGALTSQ 808 S L + + Sbjct: 856 ISFSSSTSLSPFSEE 870 Score = 31.2 bits (69), Expect = 4.1 Identities = 46/203 (22%), Positives = 76/203 (37%), Gaps = 43/203 (21%) Query: 596 SSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCN---------- 645 SSPES++ G SPL++ PG P L+ + S + + Sbjct: 356 SSPESAQSTFEGFPQSPLQI--------PGSPSFSSTLLSLFQSSPERTHSTFEGFPQSP 407 Query: 646 ---PLSGAFSG-VSNIFSFWGDSRGRQYQELPRCPAPTP-------SLLNIPLSSPGRRP 694 P++ +FS + +I +S ++ P+ P P +LL++ SSP R Sbjct: 408 LQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSSFSYTLLSLFQSSPER-- 465 Query: 695 RGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAV--------TTPGP 746 S + + ++ S+ +T+L L Q + +P Sbjct: 466 ---THSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEGFPQSPLQIPQSPPE 522 Query: 747 GPTSTSPLLPVSPLPTLTLDSLS 769 G + SPL V LP DSLS Sbjct: 523 GENTHSPLQIVPSLPEWE-DSLS 544 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.138 0.423 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 36,985,031 Number of Sequences: 37866 Number of extensions: 2077221 Number of successful extensions: 15614 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 117 Number of HSP's successfully gapped in prelim test: 707 Number of HSP's that attempted gapping in prelim test: 12398 Number of HSP's gapped (non-prelim): 3403 length of query: 819 length of database: 18,247,518 effective HSP length: 111 effective length of query: 708 effective length of database: 14,044,392 effective search space: 9943429536 effective search space used: 9943429536 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.