Search of human proteins with 26051273

Search of human proteins with 26051273

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|26051273 voltage-gated potassium channel, subfamily H,
member 2 isoform c [Homo sapiens]
         (819 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|26051273 voltage-gated potassium channel, subfamily H, member...  1663   0.0  
gi|4557729 voltage-gated potassium channel, subfamily H, member ...  1598   0.0  
gi|27886653 potassium voltage-gated channel, subfamily H, member...   903   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   872   0.0  
gi|26051271 voltage-gated potassium channel, subfamily H, member...   863   0.0  
gi|27886651 potassium voltage-gated channel, subfamily H, member...   759   0.0  
gi|27886665 potassium voltage-gated channel, subfamily H, member...   592   e-169
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   478   e-135
gi|27886667 potassium voltage-gated channel, subfamily H, member...   476   e-134
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   473   e-133
gi|27437001 potassium voltage-gated channel, subfamily H, member...   462   e-130
gi|22024390 potassium voltage-gated channel, subfamily H, member...   461   e-130
gi|27886648 potassium voltage-gated channel, subfamily H, member...   461   e-130
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   448   e-126
gi|27886646 potassium voltage-gated channel, subfamily H, member...   408   e-113
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   175   2e-43
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   174   2e-43
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   173   7e-43
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   172   1e-42
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   157   3e-38
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   157   3e-38
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   148   2e-35
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   148   2e-35
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    140   6e-33
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    133   6e-31
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    98   3e-20
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]     95   3e-19
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       48   3e-05
gi|5031767 heat shock transcription factor 1 [Homo sapiens]            46   2e-04
gi|58530876 melanoma antigen family C, 1 [Homo sapiens]                44   6e-04

>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score = 1663 bits (4306), Expect = 0.0
 Identities = 819/819 (100%), Positives = 819/819 (100%)

Query: 1   MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTI 60
           MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTI
Sbjct: 1   MAAPAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTI 60

Query: 61  LHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVD 120
           LHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVD
Sbjct: 61  LHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVD 120

Query: 121 IMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEEL 180
           IMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEEL
Sbjct: 121 IMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEEL 180

Query: 181 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 240
           IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD
Sbjct: 181 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 240

Query: 241 SRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF 300
           SRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF
Sbjct: 241 SRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF 300

Query: 301 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY 360
           SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY
Sbjct: 301 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEY 360

Query: 361 FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKT 420
           FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKT
Sbjct: 361 FQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKT 420

Query: 421 THAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG 480
           THAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG
Sbjct: 421 THAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG 480

Query: 481 DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGG 540
           DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGG
Sbjct: 481 DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGG 540

Query: 541 FSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPES 600
           FSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPES
Sbjct: 541 FSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPES 600

Query: 601 SEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSF 660
           SEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSF
Sbjct: 601 SEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSF 660

Query: 661 WGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADM 720
           WGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADM
Sbjct: 661 WGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADM 720

Query: 721 ATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL 780
           ATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL
Sbjct: 721 ATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEEL 780

Query: 781 PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819
           PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS
Sbjct: 781 PPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
            isoform a [Homo sapiens]
          Length = 1159

 Score = 1598 bits (4138), Expect = 0.0
 Identities = 783/784 (99%), Positives = 784/784 (100%)

Query: 36   EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
            +VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE
Sbjct: 376  QVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 435

Query: 96   TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
            TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK
Sbjct: 436  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 495

Query: 156  GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 215
            GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC
Sbjct: 496  GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 555

Query: 216  TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275
            TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL
Sbjct: 556  TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615

Query: 276  YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335
            YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT
Sbjct: 616  YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675

Query: 336  QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395
            QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS
Sbjct: 676  QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735

Query: 396  LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455
            LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV
Sbjct: 736  LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795

Query: 456  VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS 515
            VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS
Sbjct: 796  VAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSS 855

Query: 516  LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 575
            LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA
Sbjct: 856  LEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 915

Query: 576  GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 635
            GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME
Sbjct: 916  GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 975

Query: 636  DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 695
            DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR
Sbjct: 976  DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 1035

Query: 696  GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL 755
            GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL
Sbjct: 1036 GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLL 1095

Query: 756  PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS 815
            PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS
Sbjct: 1096 PVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGS 1155

Query: 816  DPGS 819
            DPGS
Sbjct: 1156 DPGS 1159


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
            isoform 1 [Homo sapiens]
          Length = 1196

 Score =  903 bits (2334), Expect = 0.0
 Identities = 485/721 (67%), Positives = 546/721 (75%), Gaps = 35/721 (4%)

Query: 36   EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
            +VLSLGADVLPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL +
Sbjct: 376  QVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLND 435

Query: 96   TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
             EE     ECGY+C PL VVDLIVDIMFI+DILINFRTTYVN NEEVVS P +IA+HYFK
Sbjct: 436  REE-QKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFK 494

Query: 156  GWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 212
            GWFLIDMVAAIPFDLLIFGSGS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVL L
Sbjct: 495  GWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLML 554

Query: 213  LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKY 271
            LMC FALIAHWLACIWYAIGN+E+P++  +IGWL +LG QIGK YN S    GPSIKDKY
Sbjct: 555  LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614

Query: 272  VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331
            VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA
Sbjct: 615  VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674

Query: 332  RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLH 391
            RYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLH
Sbjct: 675  RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734

Query: 392  LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 451
            LN++LLQ+CK FRGA+KGCLRALAMKFKTTHAPPGDTLVH GD+LTALYF+SRGSIEIL+
Sbjct: 735  LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794

Query: 452  GDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDH 511
             D+VVAILGKNDIFGE ++LYA+PGKSN DVRALTYCDLHKI R+DLLEVLDMYPEFSDH
Sbjct: 795  DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854

Query: 512  FWSSLEITFNLRDTNM---IPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSAL 568
            F ++LE+TFNLR  +    +  S    + EG   + R+RKLSF    +K+        + 
Sbjct: 855  FLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSA 914

Query: 569  GPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPP 628
               R              + E  S   S   S +DE            P  S      P 
Sbjct: 915  DTIRHYQSSKRH------FEEKKSRSSSFISSIDDEQK----------PLFSGIVDSSPG 958

Query: 629  GGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAP---TPSLLNI 685
             G+    D E++     P SG         S    +  R ++     P P   +PS L  
Sbjct: 959  IGKASGLDFEETV----PTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQR 1014

Query: 686  PL----SSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAV 741
                   +      G+VE RLD LQ QLNRLE++++ D+ T+LQLLQ+Q T+VPPAYS V
Sbjct: 1015 AAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMV 1074

Query: 742  T 742
            T
Sbjct: 1075 T 1075


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  872 bits (2254), Expect = 0.0
 Identities = 507/846 (59%), Positives = 577/846 (68%), Gaps = 89/846 (10%)

Query: 7   KASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPF 66
           ++S T  +   A    V R   ++  V Q VLSLGADVLPEYKLQAPRIHRWTILHYSPF
Sbjct: 197 RSSSTTEIEIIAPHKVVERTQNVTEKVTQ-VLSLGADVLPEYKLQAPRIHRWTILHYSPF 255

Query: 67  KAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVD 126
           KAVWDWLILLLVIYTAVFTPYSAAFLL + +E      C Y C PL VVDLIVDIMF+VD
Sbjct: 256 KAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA-CSYTCSPLTVVDLIVDIMFVVD 314

Query: 127 ILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGL 183
           I+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVAAIPFDLLIF +GS+E   LIGL
Sbjct: 315 IVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGL 374

Query: 184 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 243
           LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGN+E+P+++ +I
Sbjct: 375 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKI 434

Query: 244 GWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSI 302
           GWL +LG Q+GK YN S    GPS++DKYVTALYFTFSSLTSVGFGNVSPNTNSEK+FSI
Sbjct: 435 GWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSI 494

Query: 303 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQ 362
           CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+EFIRFHQIPNPLRQRLEEYFQ
Sbjct: 495 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQ 554

Query: 363 HAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTH 422
           HAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC  F GA KGCLRALA+KFKTTH
Sbjct: 555 HAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTH 614

Query: 423 APPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDV 482
           APPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGKNDIFGEP++L+A+PGKS+ DV
Sbjct: 615 APPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADV 674

Query: 483 RALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDT-----NMIPGSPGSTEL 537
           RALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFNLRD      +    +PGS + 
Sbjct: 675 RALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDH 734

Query: 538 EGGFSRQRKRKLSFRRRTDKDTEQPGEV---------SALGPG---RAGAGPSSRGRPGG 585
           +G F             +D  +  P E+         S LGPG     GAGP + G P  
Sbjct: 735 QGFF------------LSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHPDA 782

Query: 586 --PWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLM--EDCEKSS 641
             P   S +SG   PE  ++           + P  SP+ P E P   PL      E+  
Sbjct: 783 APPLSISDASG-LWPELLQE-----------MPPRHSPQSPQEDPDCWPLKLGSRLEQLQ 830

Query: 642 DTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESR 701
              N L    S  S++      SR  Q  + P        +L  P S+         +  
Sbjct: 831 AQMNRLESRVS--SDL------SRILQLLQKPMPQGHASYILEAPASN---------DLA 873

Query: 702 LDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLP 761
           L  +  +      RL        Q          P+Y  +    P   ++SP +P   L 
Sbjct: 874 LVPIASETTSPGPRLPQGFLPPAQ---------TPSYGDLDDCSPKHRNSSPRMP--HLA 922

Query: 762 TLTLDSLSQVSQFMACEEL--PPGAPELPQE------GPTRRLSLPGQLGALTSQ-PLHR 812
             T  +L+  S+    E L  P  +P  P E      GP    SLP  LG++  Q    R
Sbjct: 923 VATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFS-SLPEHLGSVPKQLDFQR 981

Query: 813 HGSDPG 818
           HGSDPG
Sbjct: 982 HGSDPG 987


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  863 bits (2231), Expect = 0.0
 Identities = 424/425 (99%), Positives = 425/425 (100%)

Query: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
           +VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE
Sbjct: 376 QVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 435

Query: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
           TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK
Sbjct: 436 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 495

Query: 156 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 215
           GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC
Sbjct: 496 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 555

Query: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275
           TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL
Sbjct: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615

Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335
           YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT
Sbjct: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675

Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395
           QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS
Sbjct: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735

Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455
           LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV
Sbjct: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795

Query: 456 VAILG 460
           VAILG
Sbjct: 796 VAILG 800


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  759 bits (1960), Expect = 0.0
 Identities = 397/543 (73%), Positives = 428/543 (78%), Gaps = 62/543 (11%)

Query: 7   KASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPF 66
           ++S T  +   A    V R   ++  V Q VLSLGADVLPEYKLQAPRIHRWTILHYSPF
Sbjct: 197 RSSSTTEIEIIAPHKVVERTQNVTEKVTQ-VLSLGADVLPEYKLQAPRIHRWTILHYSPF 255

Query: 67  KAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVD 126
           KAVWDWLILLLVIYTAVFTPYSAAFLL + +E      C Y C PL VVDLIVDIMF+VD
Sbjct: 256 KAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA-CSYTCSPLTVVDLIVDIMFVVD 314

Query: 127 ILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGL 183
           I+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVAAIPFDLLIF +GS+E   LIGL
Sbjct: 315 IVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGL 374

Query: 184 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 243
           LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI                
Sbjct: 375 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI---------------- 418

Query: 244 GWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSIC 303
                                                SLTSVGFGNVSPNTNSEK+FSIC
Sbjct: 419 ------------------------------------CSLTSVGFGNVSPNTNSEKVFSIC 442

Query: 304 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQH 363
           VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+EFIRFHQIPNPLRQRLEEYFQH
Sbjct: 443 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQH 502

Query: 364 AWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHA 423
           AWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC  F GA KGCLRALA+KFKTTHA
Sbjct: 503 AWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHA 562

Query: 424 PPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVR 483
           PPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGKNDIFGEP++L+A+PGKS+ DVR
Sbjct: 563 PPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVR 622

Query: 484 ALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDT-----NMIPGSPGSTELE 538
           ALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFNLRD      +    +PGS + +
Sbjct: 623 ALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQ 682

Query: 539 GGF 541
           G F
Sbjct: 683 GFF 685



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 79/250 (31%), Positives = 103/250 (41%), Gaps = 71/250 (28%)

Query: 619 SSPRP-PGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPA 677
           SSPR  PG        + D    SD   PLS     +S+    W +      QE+P   +
Sbjct: 670 SSPRQAPGSQDHQGFFLSD--NQSDAAPPLS-----ISDASGLWPEL----LQEMPPRHS 718

Query: 678 PTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQM------ 731
           P       P   P   P   + SRL+ LQ Q+NRLE+R+S+D++ +LQLLQ+ M      
Sbjct: 719 PQS-----PQEDPDCWPL-KLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHAS 772

Query: 732 -----------TLVPPAYSAVTTPGP-------GPTST----------------SPLLPV 757
                       LVP A S  T+PGP        P  T                SP +P 
Sbjct: 773 YILEAPASNDLALVPIA-SETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMP- 830

Query: 758 SPLPTLTLDSLSQVSQFMACEEL--PPGAPELPQE------GPTRRLSLPGQLGALTSQ- 808
             L   T  +L+  S+    E L  P  +P  P E      GP    SLP  LG++  Q 
Sbjct: 831 -HLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFS-SLPEHLGSVPKQL 888

Query: 809 PLHRHGSDPG 818
              RHGSDPG
Sbjct: 889 DFQRHGSDPG 898


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  592 bits (1527), Expect = e-169
 Identities = 296/345 (85%), Positives = 315/345 (91%), Gaps = 5/345 (1%)

Query: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
           +VLSLGADVLPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL +
Sbjct: 369 QVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLND 428

Query: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
            EE     ECGY+C PL VVDLIVDIMFI+DILINFRTTYVN NEEVVS P +IA+HYFK
Sbjct: 429 REE-QKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFK 487

Query: 156 GWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 212
           GWFLIDMVAAIPFDLLIFGSGS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVL L
Sbjct: 488 GWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLML 547

Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKY 271
           LMC FALIAHWLACIWYAIGN+E+P++  +IGWL +LG QIGK YN S    GPSIKDKY
Sbjct: 548 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 607

Query: 272 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331
           VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA
Sbjct: 608 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 667

Query: 332 RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAV 376
           RYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN V
Sbjct: 668 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 712


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  478 bits (1231), Expect = e-135
 Identities = 316/800 (39%), Positives = 437/800 (54%), Gaps = 77/800 (9%)

Query: 45  LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 104
           +PEYK+ +    R  +LHYS  KA+WD LILL   Y AV  PY+  F     ++  P T 
Sbjct: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260

Query: 105 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 164
                +   V D+ V+++FI+DI++NFRTTYV+ + +V+S P  I +HY   WF ID++A
Sbjct: 261 -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315

Query: 165 AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 223
           A+PFDLL IF      L+ LLKT RLLRL+R+ +KL+RYS+  A VL LLM  FAL+AHW
Sbjct: 316 ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375

Query: 224 LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 280
           +ACIWY IG  E    D     IGWLH LG ++  PY +  +GGPS +  Y+ ALYFT S
Sbjct: 376 MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435

Query: 281 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 340
           SLTSVGFGNV  NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS  + YH++M  +
Sbjct: 436 SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495

Query: 341 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 400
           ++FIR H++P PL+QR+ EYFQ  W+  +GID N +L+ FP+ L+ADI +HLNR +LQ  
Sbjct: 496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554

Query: 401 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 460
             F  A++GCLRAL++  KT+   PG+ L+  GD L A Y++  GS+E+LR ++V+AILG
Sbjct: 555 PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614

Query: 461 KNDIFGEPL-------NLYARPG---KSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSD 510
           K D+ G  +        L A P    K++ DV+ALTYC L ++    L EVL +YPE+  
Sbjct: 615 KGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGA 674

Query: 511 HFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSR-QRKRKLSFRRRTDKDTEQPGEVSA 567
            F + L  ++TFNLR      GS  S     G SR  R  +LS  R     +     + +
Sbjct: 675 AFRAGLPRDLTFNLRQ-----GSDTS-----GLSRFSRSPRLSQPRSESLGSSSDKTLPS 724

Query: 568 LGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESS-----EDEGPGRS---SSPLRLVPFS 619
           +    +GA P    RP  P    P+  P+ P  S      +E P  S   SSP  L P  
Sbjct: 725 ITEAESGAEPGGGPRPRRPL-LLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSL 782

Query: 620 SPRPPGE----PPGGEPLMEDCEKSSDTCNPLSGAF----------SGVSNIFSFWGDSR 665
           SP   G+     P G P      K      P  G F           G+ +  S   ++ 
Sbjct: 783 SPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGS-TAEAP 841

Query: 666 GRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQ 725
             ++   P  P P            G RP  ++ S  + ++ ++ RL   +S     V Q
Sbjct: 842 SFRFSRRPELPRPRSQ-----APPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQ 896

Query: 726 LLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAP 785
            L R++  +     A   P PG  + S   P  P P L    LS       C   PP  P
Sbjct: 897 -LSRELRHIMGLLQARLGP-PGHPAGSAWTPDPPCPQLRPPCLS------PCASRPP--P 946

Query: 786 ELPQEGPTRRLSLPGQLGAL 805
            L Q+     +  P  +G +
Sbjct: 947 SL-QDTTLAEVHCPASVGTM 965


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  476 bits (1226), Expect = e-134
 Identities = 290/725 (40%), Positives = 415/725 (57%), Gaps = 52/725 (7%)

Query: 46  PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATEC 105
           PEYK+   +  ++ +LH+S FKA WDWLILL   Y AV  PY+  F+  +      +T  
Sbjct: 200 PEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST-- 257

Query: 106 GYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAA 165
                   V D+ V+I+FI+DI++NFRTTYV+ + +V+     I +HY   WF+ID++AA
Sbjct: 258 -------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAA 310

Query: 166 IPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL 224
           +PFDLL  F      L+ LLKT RLLRL+R+ +KLDRYS++   VL LLM  FAL+AHW+
Sbjct: 311 LPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWM 370

Query: 225 ACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSIKDKYVTALYFTFS 280
           ACIWY IG ME+     +   +GWLH LG ++  PY  ++ LGGPSI+  Y+ ALYFT S
Sbjct: 371 ACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLS 430

Query: 281 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 340
           SLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS  + YHT+   +
Sbjct: 431 SLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDL 490

Query: 341 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 400
           ++FIR H +P  L+QR+ EYFQ  WS  NGID N +LK FP+ L++DI +HLN+ +LQ  
Sbjct: 491 KDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-L 549

Query: 401 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 460
             F  A++GCLR+L++  KT+   PG+ L+  GD L A+YF+  GS+E+L+  +V+AILG
Sbjct: 550 SLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILG 609

Query: 461 KNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EI 518
           K D+ G  L++  +  K+N DV+ALTYCDL  I    L EVLD+YPE++  F   +  ++
Sbjct: 610 KGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDL 669

Query: 519 TFNLRD-------TNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPG 571
           T+NLR+       + +   S  S     G     KR  S     +++ E   E +     
Sbjct: 670 TYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSP 729

Query: 572 RAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGE--PPG 629
               G SSR +  G        G S  + +    P    SP+R+   +SP+   E  PP 
Sbjct: 730 ICTRGSSSRNKKVG--SNKAYLGLSLKQLASGTVP--FHSPIRVSRSNSPKTKQEIDPPN 785

Query: 630 GEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSS 689
                E   K   +    +G       I    G   G   +E       +  + + P  S
Sbjct: 786 HNKRKEKNLKLQLSTLNNAGPPDLSPRIVD--GIEDGNSSEESQTFDFGSERIRSEPRIS 843

Query: 690 PGRRPRGDVE-------SRLDALQRQLNRLE----------TRLSADMATVLQLLQRQMT 732
           P   P GD E        + +  ++Q+N+L           ++L  DM  V+QLL+  ++
Sbjct: 844 P---PLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS 900

Query: 733 LVPPA 737
              P+
Sbjct: 901 PQQPS 905


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  473 bits (1216), Expect = e-133
 Identities = 244/525 (46%), Positives = 340/525 (64%), Gaps = 32/525 (6%)

Query: 14  LRPRAQKGR-VRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDW 72
           L P  QKG  V +  R++     EVL LG+D+LP+YK +AP+     ILHY  FK  WDW
Sbjct: 168 LAPSVQKGENVHKHSRLA-----EVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDW 222

Query: 73  LILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 132
           +IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI++NF 
Sbjct: 223 IILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDIVLNFH 270

Query: 133 TTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTAR 188
           TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   LK  R
Sbjct: 271 TTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVR 330

Query: 189 LLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI----G 244
           LLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E    D++      
Sbjct: 331 LLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNS 390

Query: 245 WLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 298
           WL+ L   IG PY  +G G      GPS    Y+++LYFT +SLTSVGFGN++P+T+ EK
Sbjct: 391 WLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK 450

Query: 299 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLE 358
           IF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ 
Sbjct: 451 IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVM 510

Query: 359 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKF 418
           +Y    WS + GID   VL+  P+ ++ADIC+HLNR + +    FR A+ GCLRALAM+F
Sbjct: 511 DYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEF 570

Query: 419 KTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKS 478
           +T H  PGD + HAG+ + +L F+  GS+E+++ D VVAILGK D+FG+     A   +S
Sbjct: 571 QTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQS 630

Query: 479 NGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 523
             +VRALTYCDLH I RD L +VL+ Y  FS  F  +L +T+NLR
Sbjct: 631 CANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  462 bits (1189), Expect = e-130
 Identities = 244/552 (44%), Positives = 340/552 (61%), Gaps = 59/552 (10%)

Query: 14  LRPRAQKGR-VRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDW 72
           L P  QKG  V +  R++     EVL LG+D+LP+YK +AP+     ILHY  FK  WDW
Sbjct: 168 LAPSVQKGENVHKHSRLA-----EVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDW 222

Query: 73  LILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 132
           +IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI++NF 
Sbjct: 223 IILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDIVLNFH 270

Query: 133 TTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF------------------- 173
           TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++                     
Sbjct: 271 TTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGF 330

Query: 174 ------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 221
                         G   L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L A
Sbjct: 331 ADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAA 390

Query: 222 HWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPSIKDKY 271
           HW+ACIWY+IG+ E    D++      WL+ L   IG PY  +G G      GPS    Y
Sbjct: 391 HWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVY 450

Query: 272 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331
           +++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T 
Sbjct: 451 ISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTN 510

Query: 332 RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLH 391
           RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++ADIC+H
Sbjct: 511 RYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVH 570

Query: 392 LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 451
           LNR + +    FR A+ GCLRALAM+F+T H  PGD + HAG+ + +L F+  GS+E+++
Sbjct: 571 LNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ 630

Query: 452 GDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDH 511
            D VVAILGK D+FG+     A   +S  +VRALTYCDLH I RD L +VL+ Y  FS  
Sbjct: 631 DDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHS 690

Query: 512 FWSSLEITFNLR 523
           F  +L +T+NLR
Sbjct: 691 FSRNLILTYNLR 702


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  461 bits (1187), Expect = e-130
 Identities = 234/501 (46%), Positives = 329/501 (65%), Gaps = 25/501 (4%)

Query: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
           EVL LG+D+LP+YK +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F  K+
Sbjct: 183 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 242

Query: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
                             V+D +VD++F+VDI++NF TT+V    EV+S P  I ++Y K
Sbjct: 243 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 290

Query: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211
            WF+ID+++ +P+D++        G   L   LK  RLLRL RVARKLD Y EYGAAVL 
Sbjct: 291 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 350

Query: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262
           LL+C F L+AHWLACIWY+IG+ E    + + I    WL+ L   IG PY    S+G+  
Sbjct: 351 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 410

Query: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322
           GGPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I
Sbjct: 411 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 470

Query: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382
            Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL   P+
Sbjct: 471 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 530

Query: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442
            ++ADIC+HLNR +      FR A+ GCLRALA++F+T H  PGD + HAG+ + AL F+
Sbjct: 531 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 590

Query: 443 SRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 502
             GS+E+++ D VVAILGK D+FG+          +  +VRALTYCDLH I R+ LL+VL
Sbjct: 591 VSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVL 650

Query: 503 DMYPEFSDHFWSSLEITFNLR 523
           D Y  F++ F  +L +T NLR
Sbjct: 651 DFYTAFANSFSRNLTLTCNLR 671


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  461 bits (1187), Expect = e-130
 Identities = 234/501 (46%), Positives = 329/501 (65%), Gaps = 25/501 (4%)

Query: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
           EVL LG+D+LP+YK +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F  K+
Sbjct: 125 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 184

Query: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
                             V+D +VD++F+VDI++NF TT+V    EV+S P  I ++Y K
Sbjct: 185 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 232

Query: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211
            WF+ID+++ +P+D++        G   L   LK  RLLRL RVARKLD Y EYGAAVL 
Sbjct: 233 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 292

Query: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262
           LL+C F L+AHWLACIWY+IG+ E    + + I    WL+ L   IG PY    S+G+  
Sbjct: 293 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 352

Query: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322
           GGPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I
Sbjct: 353 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 412

Query: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382
            Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL   P+
Sbjct: 413 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 472

Query: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442
            ++ADIC+HLNR +      FR A+ GCLRALA++F+T H  PGD + HAG+ + AL F+
Sbjct: 473 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 532

Query: 443 SRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 502
             GS+E+++ D VVAILGK D+FG+          +  +VRALTYCDLH I R+ LL+VL
Sbjct: 533 VSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVL 592

Query: 503 DMYPEFSDHFWSSLEITFNLR 523
           D Y  F++ F  +L +T NLR
Sbjct: 593 DFYTAFANSFSRNLTLTCNLR 613


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  448 bits (1153), Expect = e-126
 Identities = 300/782 (38%), Positives = 408/782 (52%), Gaps = 119/782 (15%)

Query: 45  LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 104
           LPEYK+ A R   + +LH    +A WD  ILL  +Y AV  PYS             A E
Sbjct: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253

Query: 105 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 164
              A  P +V DL V+++FI+DI++NFRTT+V+ + +VV  P  I +HY   WFL+D++A
Sbjct: 254 PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313

Query: 165 AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 217
           A+PFDLL        FG+       LLKT RLLRL+R+  +LDRYS+Y A VL LLM  F
Sbjct: 314 ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367

Query: 218 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 261
           AL+AHW+AC+W+ IG  E    +S    IGWL  L  ++  PY          NSSG   
Sbjct: 368 ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427

Query: 262 ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 306
                          LGGPS++  Y+T+LYF  SSLTSVGFGNVS NT++EKIFSIC ML
Sbjct: 428 NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487

Query: 307 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 366
           IG+LM+A +FGNV+AIIQR+Y+    YH++   +R++IR H+IP PL+QR+ EYFQ  W+
Sbjct: 488 IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547

Query: 367 YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 426
             NGID   +L+  P+ L+ADI +HL++ +LQ    F  A++GCLRAL++  +     PG
Sbjct: 548 VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606

Query: 427 DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALT 486
           + L+H GD L ALYF+  GS+E+L+G  V+AILGK D+ G  L    +  K+N DV+ LT
Sbjct: 607 EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLT 666

Query: 487 YCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSRQ 544
           YC L  +    L + L +YPEF+  F   L  E+++NL          GS E++      
Sbjct: 667 YCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL------GAGGGSAEVDTSSLSG 720

Query: 545 RKRKLSFRRRTDKDTEQ------------------PGEVSA------LGPGRAGAGP--S 578
               +S     + D EQ                  PG  S+      L P R    P   
Sbjct: 721 DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780

Query: 579 SRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCE 638
            RGRPG        +GPS+P         R+   LRL P     PP   P    +++  E
Sbjct: 781 GRGRPGRAGALKAEAGPSAPP--------RALEGLRLPPMPWNVPPDLSP---RVVDGIE 829

Query: 639 KSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDV 698
               +  P           FSF     G +    P  P P   LL +P   P      D 
Sbjct: 830 DGCGSDQPK----------FSFRVGQSGPECSSSP-SPGPESGLLTVP-HGPSEARNTDT 877

Query: 699 ESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTP-----GPGPTSTSP 753
              LD L++ +  L  ++   M   LQ L++ + LV   +     P     GP P STS 
Sbjct: 878 ---LDKLRQAVTELSEQV-LQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSG 933

Query: 754 LL 755
           LL
Sbjct: 934 LL 935


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  408 bits (1048), Expect = e-113
 Identities = 204/437 (46%), Positives = 289/437 (66%), Gaps = 25/437 (5%)

Query: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95
           EVL LG+D+LP+YK +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F  K+
Sbjct: 183 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 242

Query: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155
                             V+D +VD++F+VDI++NF TT+V    EV+S P  I ++Y K
Sbjct: 243 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 290

Query: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211
            WF+ID+++ +P+D++        G   L   LK  RLLRL RVARKLD Y EYGAAVL 
Sbjct: 291 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 350

Query: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262
           LL+C F L+AHWLACIWY+IG+ E    + + I    WL+ L   IG PY    S+G+  
Sbjct: 351 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 410

Query: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322
           GGPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I
Sbjct: 411 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 470

Query: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382
            Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL   P+
Sbjct: 471 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 530

Query: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442
            ++ADIC+HLNR +      FR A+ GCLRALA++F+T H  PGD + HAG+ + AL F+
Sbjct: 531 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 590

Query: 443 SRGSIEILRGDVVVAIL 459
             GS+E+++ D VVAIL
Sbjct: 591 VSGSLEVIQDDEVVAIL 607


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  175 bits (443), Expect = 2e-43
 Identities = 176/783 (22%), Positives = 318/783 (40%), Gaps = 107/783 (13%)

Query: 58  WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117
           W I  YS F+  WD ++L++++   V  P    F  ++T              P  + ++
Sbjct: 133 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTT------------PWIIFNV 180

Query: 118 IVDIMFIVDILINFRTTYVNANE-EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 173
             D +F++D+++NFRT  VN +  E++  P  I ++Y K WF++D +++IP D +     
Sbjct: 181 ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE 240

Query: 174 -GSGSE--------------ELIGLLKTARLLRLVRVARKLDR-----YSEYGAAV-LFL 212
            G  SE              +++ LL+  RL RL+R   + +      Y    A V +F 
Sbjct: 241 KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN 300

Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272
           L+    L+ HW  C+ + +  ++    D  +     + D  GK Y+              
Sbjct: 301 LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSY------------- 347

Query: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332
            AL+   S +  +G+G  +P + S+   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 348 -ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQ 406

Query: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392
           Y  +  +V +++ FH++P  +RQ++ +Y++H +      D   +L    + L+ +I    
Sbjct: 407 YQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFN 465

Query: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452
            R L+     F  A    + A+  K +     PGD ++  G +   +YFI  G   ++  
Sbjct: 466 CRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK 525

Query: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 512
                 L     FGE   L    G+    VRA TYC L+ +  D+  EVL+ YP     F
Sbjct: 526 SSKEMKLTDGSYFGEICLL--TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 583

Query: 513 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQP------GE 564
            + +++    +   N I       +L  G F+ Q    L    + D++  Q        +
Sbjct: 584 ETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQ 643

Query: 565 VSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPP 624
           ++ L    +   P+SR R   P                   P  +++ L      SP P 
Sbjct: 644 MTTLNSTSSTTTPTSRMRTQSP-------------------PVYTATSLSHSNLHSPSPS 684

Query: 625 GEPPGGEPLMEDCEKSSDTCNP------LSGAF---SGVSNIFSFWGDSRGRQYQE---- 671
            + P    ++  C  ++  C+P       +  F   S  ++  S       +Q Q+    
Sbjct: 685 TQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPP 744

Query: 672 --LPRCPAPTPSLLNIPLSSPG-RRPRGDVESRLDALQR-QLNRLETRLSADMATVLQLL 727
              P+ P+P P        +PG   P+ +V     AL    L R    LSA   ++   +
Sbjct: 745 QTQPQQPSPQP-------QTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEV 797

Query: 728 QRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPP--GAP 785
              ++   P         P P +  P   +      T+     + + M+   +PP  G P
Sbjct: 798 STLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVP 857

Query: 786 ELP 788
             P
Sbjct: 858 PAP 860


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  174 bits (442), Expect = 2e-43
 Identities = 124/474 (26%), Positives = 214/474 (45%), Gaps = 54/474 (11%)

Query: 58  WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117
           W I  YS F+  WD  +LLL++   +  P    F   E               P  V ++
Sbjct: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300

Query: 118 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 176
           + D  F++D+++NFRT   V  N E++  P RI + Y K WF++D +++IP D +     
Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360

Query: 177 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 212
           +     + KTAR LR+VR  +        +L R   Y               +AV+ +  
Sbjct: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420

Query: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272
           L+    L+ HW  C+ + +  ++    D  +   + + +  GK Y+              
Sbjct: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467

Query: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332
            AL+   S +  +G+G  +P   S+   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526

Query: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392
           Y  +  +V +++ FH++P   RQR+ +Y++H +      D  ++L    E L+ +I    
Sbjct: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585

Query: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452
            R L+     F  A    + ++  K +     PGD ++  G +   +YFI  G + +L  
Sbjct: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645

Query: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 506
                 L     FGE + L  R G+    VRA TYC L+ +  D+  EVL+ YP
Sbjct: 646 GNKETKLADGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYP 697



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 22/102 (21%)

Query: 563 GEVSALGPGRAGAGPSSRGRPGGPWGESP------SSGPSSPE--------SSEDEGPGR 608
           G +++LG    G+G +  G   G   +S       + G +SP         ++E E PG 
Sbjct: 98  GSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGA 157

Query: 609 SSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSS-DTCNPLSG 649
           S+ P      +SP PP +PP  +P    CE+ S DT   + G
Sbjct: 158 SAQPA-----ASPPPPQQPP--QPASASCEQPSVDTAIKVEG 192



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 24/72 (33%), Positives = 28/72 (38%), Gaps = 4/72 (5%)

Query: 561  QPGEVSALGPGRAGAGPSSRGRPGGPWGESP----SSGPSSPESSEDEGPGRSSSPLRLV 616
            QPG  S      + A P +RG  G P    P    S  PSS      + PG  S  L   
Sbjct: 930  QPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATG 989

Query: 617  PFSSPRPPGEPP 628
            P S+P  P   P
Sbjct: 990  PLSTPETPPRQP 1001



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 4/63 (6%)

Query: 570  PGRAGAGPS--SRGRPGGPWGESPSSGPSSPES-SEDEGPGRSSSPLRLVPFSSPRPPGE 626
            PG+ G  P   S G   GP   +P + P  PE  S   G    +SP+   P     PPG 
Sbjct: 972  PGQLGQPPGELSLGLATGPLS-TPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGH 1030

Query: 627  PPG 629
             PG
Sbjct: 1031 SPG 1033



 Score = 30.0 bits (66), Expect = 9.1
 Identities = 25/84 (29%), Positives = 33/84 (39%), Gaps = 11/84 (13%)

Query: 560  EQPGEVS-ALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEG----PGRSSSPLR 614
            + PGE+S  L  G      +   +P  P   + +SG +SP      G    PG S  P R
Sbjct: 977  QPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPR 1036

Query: 615  LVPFSSPRPPGE------PPGGEP 632
              P + PR  G       PP   P
Sbjct: 1037 TFPSAPPRASGSHGSLLLPPASSP 1060


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  173 bits (438), Expect = 7e-43
 Identities = 161/659 (24%), Positives = 271/659 (41%), Gaps = 103/659 (15%)

Query: 58  WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117
           W I  YS F+  WD+ +LL ++   +  P    F   ET              P  V ++
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249

Query: 118 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 173
           + D  F++D+++NFRT  V   N E++  P +I   Y + WF++D V++IP D +     
Sbjct: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309

Query: 174 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 216
            G  SE               +L   RLLRL R+ R + ++ E     Y  A   + +C 
Sbjct: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369

Query: 217 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272
                 L+ HW  C+ + +  ++      R  W+           + +G+   S  + Y 
Sbjct: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415

Query: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332
            AL+   S +  +G+G  +P + ++   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475

Query: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392
           Y  +  +V +++ FH++P   RQ++ +Y++H +      D +++L      L+ +I    
Sbjct: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534

Query: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452
            R L+     F  A    + A+  K K     PGD ++  G +   +YFI  G + +L  
Sbjct: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 594

Query: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 512
                 L     FGE + L  R G+    VRA TYC L+ +  D+  EVL+ YP     F
Sbjct: 595 GNKEMKLSDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652

Query: 513 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQPGEVS---- 566
            + +++    +   N I       +L  G F+ Q    +    + D++  Q  E+     
Sbjct: 653 ETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVG 712

Query: 567 ---------------------------------ALGPGRAGAGPSSRGRPGGPWGESPSS 593
                                             +GP   G+    R  P GP   + S 
Sbjct: 713 LFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASP 772

Query: 594 GPSSPESSEDEGPGRSSSPLRLVPFSSPRP--PGEPPGGEPLMEDCEKSSDTCNPLSGA 650
           GP  P S     PG  +SP    P +SP    P  P  G  L     + S    PLS +
Sbjct: 773 GPPPPASP----PGAPASP--RAPRTSPYGGLPAAPLAGPAL--PARRLSRASRPLSAS 823



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 13/75 (17%)

Query: 570 PGRAGAGPSSRGRPGGPWGE-SPSSGPSSPES------------SEDEGPGRSSSPLRLV 616
           PG  GA  +++G P G  G   P   P+ PE                 GP     P    
Sbjct: 85  PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEA 144

Query: 617 PFSSPRPPGEPPGGE 631
                 P GEP G +
Sbjct: 145 GSEEAGPAGEPRGSQ 159



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 29/109 (26%), Positives = 39/109 (35%), Gaps = 24/109 (22%)

Query: 735 PPAYSAVTTPGPGPTSTSPLLPVSPL-----------------PTLTLDSLSQVSQFMAC 777
           P    A  +PGP P ++ P  P SP                  P L    LS+ S+ ++ 
Sbjct: 763 PGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSA 822

Query: 778 EE--LPPGAP-----ELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819
            +  LP GAP       P    T RL       A    P  R  + PG+
Sbjct: 823 SQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGA 871



 Score = 30.0 bits (66), Expect = 9.1
 Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 9/58 (15%)

Query: 581 GRPGGPWGESPSSG-----PSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPL 633
           GRPG   G +P+ G     P +P   +   P   + P    P   P PP  PP  E L
Sbjct: 8   GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP----PGPGPAPPQHPPRAEAL 61


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  172 bits (436), Expect = 1e-42
 Identities = 137/536 (25%), Positives = 232/536 (43%), Gaps = 62/536 (11%)

Query: 4   PAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYK---LQAPRIHR--- 57
           P      T A  P  + G   +   + +L+   V      V   +K   ++  R+     
Sbjct: 24  PVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGA 83

Query: 58  WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117
           W I  YS F+  WD ++LLL++   +  P    F     EE  P         P  V ++
Sbjct: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131

Query: 118 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 176
           + D  F++D+++NFRT   V    E++  P  I   Y + WFL+D++++IP D +     
Sbjct: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191

Query: 177 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 210
            E  +   + KTAR LR+VR  +        +L R   Y               +AV  +
Sbjct: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251

Query: 211 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 270
           F L+    L+ HW  C+ + +  ++    D  +   H +    G+ Y+            
Sbjct: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300

Query: 271 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 330
              AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357

Query: 331 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 390
            +Y  +  +V +++ FH++P   RQR+ EY++H +      D  ++L    E L+ +I  
Sbjct: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416

Query: 391 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 450
              R L+ H   F  A    + A+  K +     PGD +V  G +   +YFI  G + +L
Sbjct: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476

Query: 451 RGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 506
                   L     FGE + L  R G+    VRA TYC L+ +  D    VL+ +P
Sbjct: 477 ARGARDTRLTDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDHFNAVLEEFP 530


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  157 bits (398), Expect = 3e-38
 Identities = 110/410 (26%), Positives = 203/410 (49%), Gaps = 37/410 (9%)

Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245

Query: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223
              G+      ++  RLL+  R+    DR             G  VL++L     +I HW
Sbjct: 246 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 298

Query: 224 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 283
            ACI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT
Sbjct: 299 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 346

Query: 284 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 343
           ++G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++
Sbjct: 347 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405

Query: 344 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 403
           ++F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F
Sbjct: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465

Query: 404 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGK 461
           +    G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L  
Sbjct: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525

Query: 462 NDIFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
              FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  157 bits (398), Expect = 3e-38
 Identities = 110/410 (26%), Positives = 203/410 (49%), Gaps = 37/410 (9%)

Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263

Query: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223
              G+      ++  RLL+  R+    DR             G  VL++L     +I HW
Sbjct: 264 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 316

Query: 224 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 283
            ACI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT
Sbjct: 317 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 364

Query: 284 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 343
           ++G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++
Sbjct: 365 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423

Query: 344 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 403
           ++F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F
Sbjct: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 483

Query: 404 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGK 461
           +    G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L  
Sbjct: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543

Query: 462 NDIFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
              FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  148 bits (373), Expect = 2e-35
 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 173
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330

Query: 174 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 231
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390

Query: 232 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 291
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437

Query: 292 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 351
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497

Query: 352 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 411
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557

Query: 412 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 469
             L +K +     PGD +   GD+   +Y I  G + ++  D V    +L     FGE  
Sbjct: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617

Query: 470 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
            L  +  K+      +++++ Y DL  + +DDL+E L  YP+
Sbjct: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 659


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  148 bits (373), Expect = 2e-35
 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 173
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 202 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 261

Query: 174 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 231
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 262 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 321

Query: 232 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 291
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 322 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 368

Query: 292 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 351
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 369 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 428

Query: 352 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 411
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 429 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 488

Query: 412 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 469
             L +K +     PGD +   GD+   +Y I  G + ++  D V    +L     FGE  
Sbjct: 489 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 548

Query: 470 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
            L  +  K+      +++++ Y DL  + +DDL+E L  YP+
Sbjct: 549 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 590


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  140 bits (352), Expect = 6e-33
 Identities = 107/418 (25%), Positives = 194/418 (46%), Gaps = 53/418 (12%)

Query: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 172
           V+D + D+++I D+ I  RT ++     +V    ++  +Y     F +D+ + IP DL+ 
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235

Query: 173 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 223
           F          ++  RLL   R+    DR                VL++L+     I HW
Sbjct: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288

Query: 224 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKD--------KYVTAL 275
            ACI+YAI       +D+   W++                 P+I D        +Y+  L
Sbjct: 289 NACIYYAISKSIGFGVDT---WVY-----------------PNITDPEYGYLAREYIYCL 328

Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335
           Y++  +LT++G     P  + E +F I   LIG L++A+I GNV ++I  + +  A +  
Sbjct: 329 YWSTLTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQA 387

Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395
           ++  V+ +++F ++   +  ++  +F + W+    +D   +LK  P  L+A+I ++++ S
Sbjct: 388 KIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLS 447

Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455
            L+  + F     G L  L +K +     PGD +   GD+   +Y I  G + ++  D V
Sbjct: 448 TLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGV 507

Query: 456 V--AILGKNDIFGEPLNLYARPGK----SNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
              A+L     FGE   L  +  K       ++R+L Y DL  + +DDL+E +  YP+
Sbjct: 508 TQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  133 bits (335), Expect = 6e-31
 Identities = 100/419 (23%), Positives = 201/419 (47%), Gaps = 30/419 (7%)

Query: 101 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 159
           P  + GY    L V+D   D+++++D+++ F T ++     VV   GRI+  Y + W F 
Sbjct: 59  PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116

Query: 160 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 215
           +D+ + +P D++    G       L+  R LR  R+    DR         A  +  LM 
Sbjct: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174

Query: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275
              ++ HW +C+++A+        D+   W++          + +  G   ++ +Y+ + 
Sbjct: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222

Query: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335
           YF+   LT+VG     P    E +F +   L+  + +A+I G++S++I  + +  A ++ 
Sbjct: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281

Query: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395
               V+++++   +   L +R+ +++QH        +  A+L+  PE L+A++ + ++ S
Sbjct: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341

Query: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455
            L   + F+      L  L +K +     PG+ +   GD+   +Y I  G + ++  D +
Sbjct: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401

Query: 456 V--AILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE 507
              A+LG    FGE +++    G  +G     ++++L Y DL  + ++DL EVL  YP+
Sbjct: 402 TQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 80/404 (19%), Positives = 185/404 (45%), Gaps = 35/404 (8%)

Query: 114  VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 171
            ++D + D+++ +DI +   R  +V   + +++    +  +Y K   F +D+++ +P D L
Sbjct: 693  LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751

Query: 172  IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 228
                G   L+ L +  + +       +L+  S    A ++ ++ T A + + L   +C++
Sbjct: 752  YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809

Query: 229  YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 288
            Y     +       +G  H + D +G              + Y+   YF   +L ++G G
Sbjct: 810  YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848

Query: 289  NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 348
               P T  E +F +     G   ++ + G +  ++    +G   Y + M    +++ F++
Sbjct: 849  LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908

Query: 349  IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 408
            IP  ++ R++ ++++ W     +D + ++   P+ ++ D+ + +N +++     F+G  +
Sbjct: 909  IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968

Query: 409  GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIF 465
              +  +  + ++    P D +   G++   +Y I  G +++L    G  V+  L    +F
Sbjct: 969  QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028

Query: 466  GEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
            GE ++L A  G  +   +V A  + +L  + + DL E+L  YPE
Sbjct: 1029 GE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 84/402 (20%), Positives = 171/402 (42%), Gaps = 31/402 (7%)

Query: 114 VVDLIVDIMFIVDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 171
           + D+I DI+++ D+L I  R  +V   + +V     +  HY     F +D+ + IPFD+ 
Sbjct: 255 IADIICDIIYLYDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDIC 313

Query: 172 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYA 230
               G   +    +  +          L+   +       +    + L I H  AC++Y 
Sbjct: 314 YLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYW 373

Query: 231 IGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNV 290
             N E         W+          Y+  G       ++Y+   Y+   +L ++G G  
Sbjct: 374 ASNYEGI---GTTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLP 412

Query: 291 SPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIP 350
            P T  E +F +     G  +++S+ G +  +I    +    +   M     ++  + IP
Sbjct: 413 EPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIP 472

Query: 351 NPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGC 410
             +++R+  ++++ W     +D + +LK  P  +Q  + + +N S++     F+G     
Sbjct: 473 KLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQM 532

Query: 411 LRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIFGE 467
           +  + ++ K+    PGD +   G++   +Y I  G +++L    G  V+  L    +FGE
Sbjct: 533 IYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE 592

Query: 468 PLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
            ++L A  G  +   +V A  + +L  + +  L E+L  YP+
Sbjct: 593 -ISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPD 633


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 61/222 (27%), Positives = 82/222 (36%), Gaps = 27/222 (12%)

Query: 592  SSGPSSPESSEDE-GPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGA 650
            SS P +P S  +   PG   SP  + P +SP     P    P+      S+ + +P S  
Sbjct: 804  SSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVS-SNPSPHPTSSP 862

Query: 651  FSGVSNIFSFWGDSRGRQYQELPRCPAPT--PSLLNIPLSSPGRRPRGDVESRLDALQRQ 708
                S+   F        +  LP    PT  P+   + LSSP   P     S        
Sbjct: 863  LPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAP 922

Query: 709  LNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTL--- 765
            L  L +  S  + TV Q L               +P PG  S SP  P SPLP+L L   
Sbjct: 923  LLSLASAFSLAVMTVAQSL--------------LSPSPGLLSQSPPAPPSPLPSLPLPPP 968

Query: 766  ------DSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQ 801
                  +S S  +  +  E  PP A  LP E     +S  G+
Sbjct: 969  VAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGK 1010


>gi|5031767 heat shock transcription factor 1 [Homo sapiens]
          Length = 529

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 63/236 (26%), Positives = 92/236 (38%), Gaps = 33/236 (13%)

Query: 590 SPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEP------PGGEPLMEDCEKSSDT 643
           +P+S  +SP  S DE P  SSSPL  V    P PP  P      PG    ++     +  
Sbjct: 272 APASPMASPGGSIDERP-LSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTAL 330

Query: 644 CNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLD 703
            + +           +   D+RG    E  R P+P P+       S     + ++   LD
Sbjct: 331 IDSILRESEPAPASVTALTDARGHTDTE-GRPPSPPPTSTPEKCLSVACLDKNELSDHLD 389

Query: 704 ALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTL 763
           A+   L+ L+T LS+                   +S  T+      S S  +P   LP L
Sbjct: 390 AMDSNLDNLQTMLSSH-----------------GFSVDTSALLDLFSPSVTVPDMSLPDL 432

Query: 764 TLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819
              SL+ + + ++ +E PP  PE     P        QL   T+QPL     DPGS
Sbjct: 433 D-SSLASIQELLSPQE-PPRPPEAENSSP----DSGKQLVHYTAQPLFL--LDPGS 480


>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
          Length = 1142

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 67/255 (26%), Positives = 97/255 (38%), Gaps = 56/255 (21%)

Query: 590 SPSSGPSS-PESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLM--EDCEKSSDTCNP 646
           +PSS P S PESS+    G   SPL     S   PP       PL   E   +  D+ +P
Sbjct: 636 TPSSLPQSFPESSQSPPEGPVQSPLH----SPQSPPEGMHSQSPLQSPESAPEGEDSLSP 691

Query: 647 LS---GAFSGVSNIFSF--------WGDS-----------RGRQYQELPRCPAP---TPS 681
           L        G  ++ S         W DS           +G  +Q   + P     + +
Sbjct: 692 LQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSST 751

Query: 682 LLNIPLS---SPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAY 738
            L++P S   SP   P G  +S    LQR ++      S  +A++LQ           ++
Sbjct: 752 SLSLPQSFPESPQSPPEGPAQS---PLQRPVSSF---FSYTLASLLQ----------SSH 795

Query: 739 SAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQ---VSQF--MACEELPPGAPELPQEGPT 793
            +  +P  GP  +    PVS  P+ T  SLSQ   VS F       L   +PE P + P 
Sbjct: 796 ESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPV 855

Query: 794 RRLSLPGQLGALTSQ 808
              S    L   + +
Sbjct: 856 ISFSSSTSLSPFSEE 870



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 46/203 (22%), Positives = 76/203 (37%), Gaps = 43/203 (21%)

Query: 596 SSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCN---------- 645
           SSPES++    G   SPL++        PG P     L+   + S +  +          
Sbjct: 356 SSPESAQSTFEGFPQSPLQI--------PGSPSFSSTLLSLFQSSPERTHSTFEGFPQSP 407

Query: 646 ---PLSGAFSG-VSNIFSFWGDSRGRQYQELPRCPAPTP-------SLLNIPLSSPGRRP 694
              P++ +FS  + +I     +S    ++  P+ P   P       +LL++  SSP R  
Sbjct: 408 LQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSSFSYTLLSLFQSSPER-- 465

Query: 695 RGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAV--------TTPGP 746
                S  +   +   ++    S+  +T+L L Q         +            +P  
Sbjct: 466 ---THSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEGFPQSPLQIPQSPPE 522

Query: 747 GPTSTSPLLPVSPLPTLTLDSLS 769
           G  + SPL  V  LP    DSLS
Sbjct: 523 GENTHSPLQIVPSLPEWE-DSLS 544


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,985,031
Number of Sequences: 37866
Number of extensions: 2077221
Number of successful extensions: 15614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 707
Number of HSP's that attempted gapping in prelim test: 12398
Number of HSP's gapped (non-prelim): 3403
length of query: 819
length of database: 18,247,518
effective HSP length: 111
effective length of query: 708
effective length of database: 14,044,392
effective search space: 9943429536
effective search space used: 9943429536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.