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Search of human proteins with 25914749
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
(1464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 2890 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 723 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 714 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 702 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 686 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 641 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 633 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 633 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 631 e-180
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 620 e-177
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 619 e-177
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 603 e-172
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 597 e-170
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 591 e-168
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 575 e-163
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 573 e-163
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 567 e-161
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 567 e-161
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 524 e-148
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 398 e-110
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 370 e-102
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 266 1e-70
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 206 2e-52
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 187 5e-47
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 172 3e-42
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 164 6e-40
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 162 2e-39
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 154 6e-37
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 151 4e-36
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 151 4e-36
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 2890 bits (7491), Expect = 0.0
Identities = 1464/1464 (100%), Positives = 1464/1464 (100%)
Query: 1 MCLLVFPLVPRSPDYILPCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVL 60
MCLLVFPLVPRSPDYILPCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVL
Sbjct: 1 MCLLVFPLVPRSPDYILPCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVL 60
Query: 61 AGCVAAVAWISHSLALWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPP 120
AGCVAAVAWISHSLALWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPP
Sbjct: 61 AGCVAAVAWISHSLALWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPP 120
Query: 121 LLPGPMARLCLLILQLAALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSR 180
LLPGPMARLCLLILQLAALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSR
Sbjct: 121 LLPGPMARLCLLILQLAALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSR 180
Query: 181 FSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGR 240
FSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGR
Sbjct: 181 FSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGR 240
Query: 241 CYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQ 300
CYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQ
Sbjct: 241 CYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQ 300
Query: 301 YGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWG 360
YGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWG
Sbjct: 301 YGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWG 360
Query: 361 LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVT 420
LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVT
Sbjct: 361 LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVT 420
Query: 421 ELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFI 480
ELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFI
Sbjct: 421 ELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFI 480
Query: 481 TYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQ 540
TYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQ
Sbjct: 481 TYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQ 540
Query: 541 AYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGML 600
AYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGML
Sbjct: 541 AYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGML 600
Query: 601 VGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGK 660
VGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGK
Sbjct: 601 VGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGK 660
Query: 661 TFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYL 720
TFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYL
Sbjct: 661 TFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYL 720
Query: 721 LDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPP 780
LDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPP
Sbjct: 721 LDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPP 780
Query: 781 SEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGAV 840
SEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGAV
Sbjct: 781 SEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGAV 840
Query: 841 ALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSP 900
ALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSP
Sbjct: 841 ALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSP 900
Query: 901 ASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVL 960
ASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVL
Sbjct: 901 ASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVL 960
Query: 961 FAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLA 1020
FAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLA
Sbjct: 961 FAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLA 1020
Query: 1021 NAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLA 1080
NAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLA
Sbjct: 1021 NAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLA 1080
Query: 1081 DTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAG 1140
DTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAG
Sbjct: 1081 DTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAG 1140
Query: 1141 IALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQE 1200
IALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQE
Sbjct: 1141 IALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQE 1200
Query: 1201 PQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSS 1260
PQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSS
Sbjct: 1201 PQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSS 1260
Query: 1261 LLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK 1320
LLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK
Sbjct: 1261 LLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK 1320
Query: 1321 DRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEA 1380
DRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEA
Sbjct: 1321 DRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEA 1380
Query: 1381 TASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRN 1440
TASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRN
Sbjct: 1381 TASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRN 1440
Query: 1441 QPHSLFQQLLQSSQQGVPASLGGP 1464
QPHSLFQQLLQSSQQGVPASLGGP
Sbjct: 1441 QPHSLFQQLLQSSQQGVPASLGGP 1464
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 723 bits (1867), Expect = 0.0
Identities = 457/1284 (35%), Positives = 693/1284 (53%), Gaps = 151/1284 (11%)
Query: 232 RALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYA-LGLAGG 290
+AL FG +L KL+ +L F P LLS+L+ F+ P G L A L
Sbjct: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
Query: 291 AVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPS---RPPTGEALNLLGTDSER 347
+ +LQ+ Y Y ++ ++ R ++ ++Y KAL + S GE +NL+ D++R
Sbjct: 361 MMQSLILQHYYHY-IFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQR 419
Query: 348 LLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQE 407
++ A + W PLQ+ + +Y L+Q +G + + G+ +LL+P+N +A ++ A +
Sbjct: 420 FMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVK 479
Query: 408 MLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLW 467
++ KD+R+KL++E+L+GI+V+K WE + +VE R EL LR YL + W
Sbjct: 480 QMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTW 539
Query: 468 AALPVVISIVIFITYVLM--GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSL 525
P +++++ YV + + L A K F +++L +L LPLN P +I+ L +A VSL
Sbjct: 540 MCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSL 599
Query: 526 DRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSW----DP 581
RIQ FL +PQ+ P + +H F+W P
Sbjct: 600 KRIQQFLSQEELDPQSV-----------------ERKTISPGYAITIHSGTFTWAQDLPP 642
Query: 582 VGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLA 641
SL+ ++V KG LV +VG VGCGKSSL++A+ GE+ +L G V ++G
Sbjct: 643 TLHSLD-----IQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG---SVAYV 694
Query: 642 TQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 701
Q+ WIQ T+++N+LFGK + + Y++ LEACAL DL +LP GDQTE+GEKG+ LSGG
Sbjct: 695 PQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGG 754
Query: 702 QRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTRLLCTHRTEY 759
QR R++LARAVY + +++LLDDPL+AVD+ VA H+ I G+L+ TR+L TH +
Sbjct: 755 QRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISF 814
Query: 760 LERADAVLLMEAGRLIRAGPPSEILP--------LVQAVPKAWAENGQESDSATA-QSVQ 810
L + D ++++ G++ GP +L L P + G DS TA + +
Sbjct: 815 LPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD--EDQGHLEDSWTALEGAE 872
Query: 811 NPE-----------------------------KTKEGLEEEQSTSGRLLQE--------- 832
+ E + L + GR +
Sbjct: 873 DKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKV 932
Query: 833 ---ESKKEGA-----------VALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWL 878
E+K +GA V L V+ Y KAVG LAI + A A+ WL
Sbjct: 933 QVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWL 992
Query: 879 SHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRF 938
S W + A++ Q +TS
Sbjct: 993 SAWTNDAMADS----RQNNTS--------------------------------------L 1010
Query: 939 YLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILN 998
L VYA + + +L A+ AAG +QAA LH+ LLH + +P +FF+ TP+GRILN
Sbjct: 1011 RLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILN 1070
Query: 999 RFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYR 1058
FS D+ D+ L ++ +LL + + L V+ + P +++ PL+++Y VQR Y
Sbjct: 1071 CFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYA 1130
Query: 1059 ASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSA 1118
A+SR+L+RL S++ SP+YSH ++T+ G SV+RA + FE + ++ NQR +
Sbjct: 1131 ATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYII 1190
Query: 1119 TMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFT 1178
+ +WL I ++ +G VV A A++ NPGLVGLS+SY+L +T L+ ++ +
Sbjct: 1191 SNRWLSIGVEFVGNCVVLFAALFAVIGRSS--LNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
Query: 1179 QTEAMLVSVERLEEYT---CDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNAL 1235
E+ +V+VER++EY+ + P +G + GW +G VEF++ + YRPGL L
Sbjct: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGS--RPPEGWPPRGEVEFRNYSVRYRPGLDLVL 1306
Query: 1236 DGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQL 1295
++ V GEK+GIVGRTG+GKSS+ L LFR+LE + G + +DG++ + + L LRSQL
Sbjct: 1307 RDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQL 1366
Query: 1296 AIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSL 1354
IIPQ+P LFSGT+R NLDP G + + +W AL+ HL ++S GLD + EGG +L
Sbjct: 1367 TIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENL 1426
Query: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNT 1414
S+GQRQL+CLARALL ++IL +DEATA++D +TD L+Q TI +F TVLTIAHRLNT
Sbjct: 1427 SVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNT 1486
Query: 1415 ILNSDRVLVLQAGRVVELDSPATL 1438
I++ RVLVL G V E DSPA L
Sbjct: 1487 IMDYTRVLVLDKGVVAEFDSPANL 1510
Score = 92.8 bits (229), Expect = 2e-18
Identities = 120/525 (22%), Positives = 228/525 (43%), Gaps = 67/525 (12%)
Query: 946 IAGVNSLCTLLRAVL--------FAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRIL 997
+AG+ LC+++++++ F G ++ + + + L+ + A+ G I+
Sbjct: 352 VAGLMFLCSMMQSLILQHYYHYIFVTG-VKFRTGIMGVIYRKALVITNSVKRASTVGEIV 410
Query: 998 NRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMY 1050
N S D D PF+ L I+LA L + +G+ +++LL+P L+
Sbjct: 411 NLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIP-LNGAV 469
Query: 1051 YHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLE--- 1107
R ++ +L+ +++ L G+ VL+ Y +E L+ +E
Sbjct: 470 AVKMRAFQVKQMKLK-------DSRIKLMSEILNGIKVLKL----YAWEPSFLKQVEGIR 518
Query: 1108 ------LNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLS 1161
L T+ T W+ + +++ + + + A V +SL
Sbjct: 519 QGELQLLRTAAYLHTTTTFTWMCSPFLV---TLITLWVYVYVDPNNVLDAEKAFVSVSLF 575
Query: 1162 YALSLT-GLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG-QPLQLGTGWLTQGGVE 1219
L L +L L+S+ TQ VS++R++++ +PQ + + G+ +
Sbjct: 576 NILRLPLNMLPQLISNLTQAS---VSLKRIQQFLSQEELDPQSVERKTISPGY----AIT 628
Query: 1220 FQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 1279
+ LP L + V G + +VG G GKSSL+ L +E G+V +
Sbjct: 629 IHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMK 688
Query: 1280 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITS 1339
G +A +PQ+ ++ + T++EN+ + Q L+ C L +
Sbjct: 689 G-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM 735
Query: 1340 M-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICK 1398
+ GG E+GE G +LS GQRQ + LARA+ +DA I +D+ ++VD + + +
Sbjct: 736 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIG 795
Query: 1399 R---FANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDS-PATLR 1439
A KT + + H ++ + +D ++VL G+V E+ PA L+
Sbjct: 796 PEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ 840
Score = 73.9 bits (180), Expect = 1e-12
Identities = 58/203 (28%), Positives = 94/203 (46%), Gaps = 13/203 (6%)
Query: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG----------FGLAT 642
L V G VGIVG+ G GKSS+ + L +G + + GL+ +
Sbjct: 1311 LHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIP 1370
Query: 643 QEPWIQFATIRDNI-LFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 701
Q+P + T+R N+ FG + ++ LE L+ +S PAG + E G LS G
Sbjct: 1371 QDPILFSGTLRMNLDPFGSYSEEDIWW-ALELSHLHTFVSSQPAGLDFQCSEGGENLSVG 1429
Query: 702 QRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLE 761
QR + LARA+ ++ + +LD+ AA+D + N L+ I T L HR +
Sbjct: 1430 QRQLVCLARALLRKSRILVLDEATAAIDLETDN-LIQATIRTQFDTCTVLTIAHRLNTIM 1488
Query: 762 RADAVLLMEAGRLIRAGPPSEIL 784
VL+++ G + P+ ++
Sbjct: 1489 DYTRVLVLDKGVVAEFDSPANLI 1511
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 714 bits (1842), Expect = 0.0
Identities = 439/1279 (34%), Positives = 684/1279 (53%), Gaps = 125/1279 (9%)
Query: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Query: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
Query: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
Query: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
Query: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
+ +++A VSL R+++FL P + G + + + A
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
Query: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
Query: 633 GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
G Q+ WIQ ++R+NILFG + Y+ V++ACAL DL ILP+GD+TE+G
Sbjct: 706 G---SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIG 762
Query: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTR 750
EKGV LSGGQ+ R++LARAVY ++YL DDPL+AVDA V H+ I GML TR
Sbjct: 763 EKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR 822
Query: 751 LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSAT 805
+L TH YL + D +++M G++ G E+L A + A E Q+++
Sbjct: 823 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENG 882
Query: 806 AQSVQNPEKTKEGLEE----------------------------EQSTSGRLLQEESKKE 837
V P K + +E +++ L + E+KKE
Sbjct: 883 VTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKE 942
Query: 838 -------------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQ 884
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 943 ETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD 1002
Query: 885 LKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYA 944
N +QE + L+VY
Sbjct: 1003 -PIVNGTQE-----------------------------------------HTKVRLSVYG 1020
Query: 945 TIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDV 1004
+ + ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++
Sbjct: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
Query: 1005 ACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSREL 1064
D +P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L
Sbjct: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
Query: 1065 RRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLD 1124
+RL S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL
Sbjct: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
Query: 1125 IRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAML 1184
+RL+ +G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +
Sbjct: 1201 VRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
Query: 1185 VSVERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQ 1243
V+VERL+EY+ + P Q Q + W G VEF++ L YR L L + +
Sbjct: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
Query: 1244 PGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPF 1303
GEK+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P
Sbjct: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
Query: 1304 LFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLL 1362
LFSG++R NLDP + D +W +L+ HL + ++++ LD E EGG +LS+GQRQL+
Sbjct: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1438
Query: 1363 CLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVL 1422
CLARALL KIL +DEATA+VD +TD L+Q TI +F + TVLTIAHRLNTI++ RV+
Sbjct: 1439 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI 1498
Query: 1423 VLQAGRVVELDSPATLRNQ 1441
VL G + E +P+ L Q
Sbjct: 1499 VLDKGEIQEYGAPSDLLQQ 1517
Score = 90.5 bits (223), Expect = 1e-17
Identities = 114/500 (22%), Positives = 219/500 (43%), Gaps = 60/500 (12%)
Query: 990 ATPTGRILNRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLL 1042
++ G I+N S D D +I L ++LA L L + +G+ ++L+
Sbjct: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM 476
Query: 1043 LPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEEN 1102
+P ++M + + A + L + + L G+ VL+ F+++
Sbjct: 477 VPVNAVMAMKTKTYQVAHMKSKDNRIKL--------MNEILNGIKVLKLYAWELAFKDKV 528
Query: 1103 LRLLE-----LNQRCQFATSATMQWL--DIRLQLMGAAVVSAIAGIALVQHQQGLANPGL 1155
L + + L + + T W+ + L AV I ++ Q + L
Sbjct: 529 LAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLAL 588
Query: 1156 VGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG---QPLQLGTGW 1212
+ L + L++ L ++SS Q VS++RL + EP +P++ G G
Sbjct: 589 FNI-LRFPLNI---LPMVISSIVQAS---VSLKRLRIFLSHEELEPDSIERRPVKDGGG- 640
Query: 1213 LTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
+ ++ + P L+G+TF + G + +VG+ G GKSSLL L ++
Sbjct: 641 --TNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKV 698
Query: 1273 SGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQ-C 1331
G V + G +A +PQ+ ++ + ++REN+ G + ++++ Q C
Sbjct: 699 EGHVAIKG-------------SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQAC 744
Query: 1332 HL---SEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
L E++ S G E+GE G +LS GQ+Q + LARA+ ++A I D+ ++VD
Sbjct: 745 ALLPDLEILPS--GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 802
Query: 1389 DQLLQQTIC---KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL--RNQPH 1443
+ + + + NKT + + H ++ + D ++V+ G++ E+ S L R+
Sbjct: 803 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
Query: 1444 SLFQQLLQSSQQGVPASLGG 1463
+ F + S++Q A G
Sbjct: 863 AEFLRTYASTEQEQDAEENG 882
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 702 bits (1811), Expect = 0.0
Identities = 429/1278 (33%), Positives = 693/1278 (54%), Gaps = 127/1278 (9%)
Query: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAG 289
L +AL+ F L LLKLV + F P LL LL+ F + L G L A+ L
Sbjct: 310 LMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFT 369
Query: 290 GAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKAL---QLGPSRPPTGEALNLLGTDSE 346
A++ + Y +K+ ++ R A++ +Y KAL L GE +NL+ D++
Sbjct: 370 AALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQ 429
Query: 347 RLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQ 406
+L++ H W LQ+ ++++ L++++G + + G+ + +L++P+N +++T+
Sbjct: 430 KLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQV 489
Query: 407 EMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYL 466
+ +++KD R+K++ E+LSGI+++K+ WE + +V+ R +EL L L +++
Sbjct: 490 KNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFV 549
Query: 467 WAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVINGLLEAKVS 524
+ PV++S+V F YVL+ L A K FT++ L +L PL+ P +I+ +L+A VS
Sbjct: 550 FQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVS 609
Query: 525 LDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGT 584
+R++ +L + + A DC ++ A F+W+
Sbjct: 610 TERLEKYLGGDDLDTSAIRH-DCNF-----------------DKAMQFSEASFTWEHDSE 651
Query: 585 SLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQE 644
+ ++ L++ G LV ++G VG GKSSL++A+ GE+ + GH+ ++G + Q+
Sbjct: 652 ATVRDVN-LDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT---AYVPQQ 707
Query: 645 PWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRA 704
WIQ TI+DNILFG F+ + Y++VLEACAL DL +LP GD E+GEKG+ LSGGQ+
Sbjct: 708 SWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQ 767
Query: 705 RIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTRLLCTHRTEYLER 762
RI+LARA YQ ++YLLDDPL+AVDA V H+ ++ + G+L TRLL TH +L +
Sbjct: 768 RISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQ 827
Query: 763 ADAVLLMEAGRLIRAGPPSEILPL------------------------------------ 786
D ++++ G ++ G S +L
Sbjct: 828 VDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGL 887
Query: 787 ---VQAVPKAWAE--------------NGQESDSATAQSVQNPEKTKEG---LEEEQSTS 826
V+ +P+ A S+ +S++N KT+ E+E+
Sbjct: 888 ISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVK 947
Query: 827 G-RLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQL 885
G +L+++E + G V +Y Y +A+G I+ + ++ ++ WLS W S
Sbjct: 948 GQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDS 1007
Query: 886 KAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYAT 945
K NS+ P D+R + VY
Sbjct: 1008 KIFNSTDY------------------------------------PASQRDMR--VGVYGA 1029
Query: 946 IAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVA 1005
+ + + A G + A+ LH++LL+ +L AP+ FF+ TPTGRI+NRF+ D++
Sbjct: 1030 LGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDIS 1089
Query: 1006 CADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELR 1065
DD+LP L + G++ L ++ P +++ PL I+Y VQ Y ++SR+LR
Sbjct: 1090 TVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLR 1149
Query: 1066 RLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDI 1125
RL S+T SP+YSH ++T++GL V+RA RF + N ++ NQ+C F+ + +WL I
Sbjct: 1150 RLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAI 1209
Query: 1126 RLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLV 1185
RL+L+G V + + +V ++ L+ VG LS AL++T L+ LV ++ E +V
Sbjct: 1210 RLELVGNLTV-FFSALMMVIYRDTLSG-DTVGFVLSNALNITQTLNWLVRMTSEIETNIV 1267
Query: 1186 SVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPG 1245
+VER+ EYT + P + W ++G ++F + + YRP L L G+T +
Sbjct: 1268 AVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSM 1327
Query: 1246 EKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLF 1305
EK+G+VGRTG+GKSSL LFR+LE + G++++DGVD + + L LR +L IIPQ+P LF
Sbjct: 1328 EKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILF 1387
Query: 1306 SGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLGQRQLLCL 1364
SG++R NLDP + D +W+AL+ HL + S+ GL E+ E G +LS+GQRQLLCL
Sbjct: 1388 SGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCL 1447
Query: 1365 ARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVL 1424
RALL +KIL +DEATA+VD +TD L+Q TI FA+ TV+TIAHRL+TI++SD+V+VL
Sbjct: 1448 GRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVL 1507
Query: 1425 QAGRVVELDSPATLRNQP 1442
G+++E SP L P
Sbjct: 1508 DNGKIIECGSPEELLQIP 1525
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 686 bits (1770), Expect = 0.0
Identities = 452/1354 (33%), Positives = 707/1354 (52%), Gaps = 123/1354 (9%)
Query: 161 LLPEDQE--PEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLAR 218
+LP QE P +D + SR + WL PL G L + LP + +L
Sbjct: 1 MLPVYQEVKPNPLQDA-NLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPED-RSQHLGE 58
Query: 219 VFQAHWQEGA----------RLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVG 268
Q W + L RA+ + + YL LG+ L+ P+ L ++
Sbjct: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIIN 118
Query: 269 FLEE----GQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKA 324
+ E L+ YA L ++ A+L + Y Y V ++ R A+ +++Y KA
Sbjct: 119 YFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKA 178
Query: 325 LQLGP---SRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFV 381
L+L + TG+ +NLL D + H W PLQ LL+ ++G++ +
Sbjct: 179 LRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCL 238
Query: 382 GGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGAR 441
G+ + ++L+P+ + + DAR++ + E+++GIR+IK WE++
Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
Query: 442 VEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALV 501
+ R +E+ ++ L + + + +I V F TYVL+G +TA++VF A+ L
Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
Query: 502 RMLILPLNNF-PWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIK----- 555
+ L + F P I + EA VS+ RIQ FL L + + P G+ ++
Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
Query: 556 WLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLL 615
W S+ P L G F+ V+ G L+ +VG VG GKSSLL
Sbjct: 419 WDKASETPT-------LQGLSFT----------------VRPGELLAVVGPVGAGKSSLL 455
Query: 616 AAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACA 675
+A+ GEL G V+V G +Q+PW+ T+R NILFGK ++ + Y++V++ACA
Sbjct: 456 SAVLGELAPSHGLVSVHGR---IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACA 512
Query: 676 LNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANH 735
L DL +L GD T +G++G TLSGGQ+AR+ LARAVYQ+ ++YLLDDPL+AVDA+V+ H
Sbjct: 513 LKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRH 572
Query: 736 LLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEIL----------- 784
L CI +L +L TH+ +YL+ A +L+++ G++++ G +E L
Sbjct: 573 LFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK 632
Query: 785 --------PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGR--LLQEES 834
P V P N S+S+ + K+G E Q T L EE+
Sbjct: 633 KDNEESEQPPVPGTPTL--RNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEEN 690
Query: 835 KKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA---ADWWLSHWISQLKAENSS 891
+ EG V Y+ Y++A + +F +LL A + A DWWLS+W ++ N
Sbjct: 691 RSEGKVGFQAYKNYFRAGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLN-- 746
Query: 892 QEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNS 951
+ + GN+ D+ +YL +Y+ +
Sbjct: 747 ------------------VTVNGGGNV------------TEKLDLNWYLGIYSGLTVATV 776
Query: 952 LCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSL 1011
L + R++L + ++ TLH ++ +L APV FF+ P GRILNRFS D+ DD L
Sbjct: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
Query: 1012 PFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLT 1071
P + ++G+++V + +PW+ + L PL I++ ++R++ +SR+++RL S T
Sbjct: 837 PLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTT 896
Query: 1072 LSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMG 1131
SP++SHL+ +L GL +RA A R +E +L+ F T +W +RL +
Sbjct: 897 RSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAIC 956
Query: 1132 AAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLE 1191
A V +A +L+ + + G VGL+LSYAL+L G+ V + E M++SVER+
Sbjct: 957 AMFVIIVAFGSLILAKT--LDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVI 1014
Query: 1192 EYTC---DLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKL 1248
EYT + P E Q +P W +G + F +V Y PG P L +T ++ EK+
Sbjct: 1015 EYTDLEKEAPWEYQKRP---PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKV 1071
Query: 1249 GIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGT 1308
GIVGRTG+GKSSL+ LFRL EP G++ +D + T+++ L LR +++IIPQEP LF+GT
Sbjct: 1072 GIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1130
Query: 1309 VRENLDPQGLHKDRALWQALKQCHLSEVITSMGG-LDGELGEGGRSLSLGQRQLLCLARA 1367
+R+NLDP H D LW AL++ L E I + G +D EL E G + S+GQRQL+CLARA
Sbjct: 1131 MRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARA 1190
Query: 1368 LLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAG 1427
+L +IL IDEATA+VD +TD+L+Q+ I ++FA+ TVLTIAHRLNTI++SD+++VL +G
Sbjct: 1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250
Query: 1428 RVVELDSPATLRNQPHSLFQQLLQSSQQGVPASL 1461
R+ E D P L SLF +++Q + A+L
Sbjct: 1251 RLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAAL 1284
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 641 bits (1654), Expect = 0.0
Identities = 414/1312 (31%), Positives = 671/1312 (51%), Gaps = 138/1312 (10%)
Query: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQ----------EPLSH 279
+W A+Y AFGR L + + +LGF+GPL +S +V + E Q E LS
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 280 G--LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQA----RGAVLNILYCKALQLGPSRPP 333
L A LA L +LQ + Y VT++ RGA+L ++Y K L+L S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 334 TGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILAL 388
GE NL+ ++ +L+ F W +P+Q+ + + LLY +G + + G + +
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 389 LLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRAR 448
LL P+ IAT++ + + L + R+K E+L GI+++K WE VE R +
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 449 ELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM-GHQLTATKVFTALALVRMLILP 507
EL L+ + +++ AA+P+ + F+T+ G+ L + F +L+L +L+ P
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP 584
Query: 508 LNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCG--------RLGAQIKWLLC 559
L V+ ++A +S+ ++ FL ++ + + G Q K +
Sbjct: 585 LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINR 644
Query: 560 SDP----------------PAEPSTV-LELHGALFSWDPVGTSLETFISHLEVK--KGML 600
P PAE + +++ FSW G+ L T +S+++++ G L
Sbjct: 645 KQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSW---GSGLAT-LSNIDIRIPTGQL 700
Query: 601 VGIVGKVGCGKSSLLAAIAGELHRLRGHV-------------AVRGLSK-GFGLATQEPW 646
IVG+VGCGKSSLL AI GE+ L G V A R ++ A Q+PW
Sbjct: 701 TMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPW 760
Query: 647 IQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
+ AT+ +NI FG F+ Q YK V +AC+L D+ +LP GDQTE+GE+G+ LSGGQR RI
Sbjct: 761 LLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 820
Query: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR--LLCTHRTEYLERAD 764
+ARA+YQ + LDDP +A+D +++HL+ IL L R +L TH+ +YL AD
Sbjct: 821 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHAD 880
Query: 765 AVLLMEAGRLIRAGPPSEILPLVQAVPKAWA----------ENGQESDSATAQS-----V 809
++ M+ G ++R G +I + + W E E+D T +
Sbjct: 881 WIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRA 940
Query: 810 QNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHV---YQAYWKAVGQG---LALAILFS 863
+ K +E+E E+ + L ++ W+ + G L + ++FS
Sbjct: 941 MYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFS 1000
Query: 864 LLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVF 923
LL + A D+WL+ W S+ N+
Sbjct: 1001 KLLKHSVIVAIDYWLATWTSEYSINNT--------------------------------- 1027
Query: 924 PLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMA 983
G +D +Y+ ++ + G L+ ++ L AA LH LL+++++
Sbjct: 1028 --------GKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILG 1079
Query: 984 PVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLL 1043
P+ FF+ TP G ILNRFS+D D +P L L + L + ++ P L+ L
Sbjct: 1080 PIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVAL 1139
Query: 1044 PPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENL 1103
PL + +Y +Q+++R +S++L+ L T PL H ++T GL+ +RA RF++ L
Sbjct: 1140 LPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML 1199
Query: 1104 RLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYA 1163
L + N SA +WL++R +GA +V A IA + G +N GLVGL L YA
Sbjct: 1200 ELTDTNNIAYLFLSAANRWLEVRTDYLGACIV-LTASIASI---SGSSNSGLVGLGLLYA 1255
Query: 1164 LSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG--QPLQLGTGWLTQGGVEFQ 1221
L++T L+ +V + E + +V+++ + + +G P Q+ W +G ++
Sbjct: 1256 LTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH 1315
Query: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
D+ + Y L L V ++PG+K+GI GRTGSGKSSL L FR+++ G++++DG+
Sbjct: 1316 DLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGI 1375
Query: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM- 1340
D S+L L LRS+L+II Q+P LFSG++R NLDP+ D LW+AL+ L ++ S+
Sbjct: 1376 DISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLP 1435
Query: 1341 GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRF 1400
GGLD + EGG + S+GQRQL CLARA + + IL +DEATAS+D T+ +LQ+ + F
Sbjct: 1436 GGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF 1495
Query: 1401 ANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQS 1452
A++TV+TIAHR++TIL +D V+V++ G ++E D+P +L Q + +F +++
Sbjct: 1496 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRA 1547
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 633 bits (1632), Expect = 0.0
Identities = 413/1314 (31%), Positives = 668/1314 (50%), Gaps = 138/1314 (10%)
Query: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQ----------EPLSH 279
+W A+Y AFGR L + + +LGF+GPL +S +V + E Q E LS
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 280 G--LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQA----RGAVLNILYCKALQLGPSRPP 333
L A LA L +LQ + Y VT++ RGA+L ++Y K L+L S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 334 TGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILAL 388
GE NL+ ++ +L+ F W +P+Q+ + + LLY +G + + G + +
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 389 LLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRAR 448
LL P+ IAT++ + + L + R+K E+L GI+++K WE VE R +
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 449 ELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM-GHQLTATKVFTALALVRMLILP 507
EL L+ + +++ AA+P+ + F+T+ G+ L + F +L+L +L+ P
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP 584
Query: 508 LNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCG--------RLGAQIKWLLC 559
L V+ ++A +S+ ++ FL ++ + + G Q K +
Sbjct: 585 LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINR 644
Query: 560 SDP----------------PAEPSTV-LELHGALFSWDPVGTSLETFISHLEVK--KGML 600
P PAE + +++ FSW G+ L T +S+++++ G L
Sbjct: 645 KQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSW---GSGLAT-LSNIDIRIPTGQL 700
Query: 601 VGIVGKVGCGKSSLLAAIAGELHRLRGHV-------------AVRGLSK-GFGLATQEPW 646
IVG+VGCGKSSLL AI GE+ L G V A R ++ A Q+PW
Sbjct: 701 TMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPW 760
Query: 647 IQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
+ AT+ +NI FG F+ Q YK V +AC+L D+ +LP GDQTE+GE+G+ LSGGQR RI
Sbjct: 761 LLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 820
Query: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR--LLCTHRTEYLERAD 764
+ARA+YQ + LDDP +A+D +++HL+ IL L R +L TH+ +YL AD
Sbjct: 821 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHAD 880
Query: 765 AVLLMEAGRLIRAGPPSEILPLVQAVPKAWA----------ENGQESDSATAQS-----V 809
++ M+ G ++R G +I + + W E E+D T +
Sbjct: 881 WIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRA 940
Query: 810 QNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHV---YQAYWKAVGQG---LALAILFS 863
+ K +E+E E+ + L ++ W+ + G L + ++FS
Sbjct: 941 MYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFS 1000
Query: 864 LLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVF 923
LL + A D+WL+ W S+ N+
Sbjct: 1001 KLLKHSVIVAIDYWLATWTSEYSINNT--------------------------------- 1027
Query: 924 PLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMA 983
G +D +Y+ ++ + G L+ ++ L AA LH LL+++++
Sbjct: 1028 --------GKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILG 1079
Query: 984 PVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLL 1043
P+ FF+ TP G ILNRFS+D D +P L L + L + ++ P L+ L
Sbjct: 1080 PIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVAL 1139
Query: 1044 PPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENL 1103
PL + +Y +Q+++R +S++L+ L T PL H ++T GL+ +RA RF++ L
Sbjct: 1140 LPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML 1199
Query: 1104 RLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYA 1163
L + N SA +WL++R +GA +V A IA + G +N GLVGL L YA
Sbjct: 1200 ELTDTNNIAYLFLSAANRWLEVRTDYLGACIV-LTASIASI---SGSSNSGLVGLGLLYA 1255
Query: 1164 LSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG--QPLQLGTGWLTQGGVEFQ 1221
L++T L+ +V + E + +V+++ + + +G P Q+ W +G ++
Sbjct: 1256 LTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH 1315
Query: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
D+ + Y L L V ++PG+K+GI GRTGSGKSSL L FR+++ G++++DG+
Sbjct: 1316 DLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGI 1375
Query: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM- 1340
D S+L L LRS+L+II Q+P LFSG++R NLDP+ D LW+AL+ L ++ S+
Sbjct: 1376 DISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLP 1435
Query: 1341 GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRF 1400
GGLD + EGG + S+GQRQL CLARA + + IL +DEATAS+D T+ +LQ+ + F
Sbjct: 1436 GGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF 1495
Query: 1401 ANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQ 1454
A++TV+TIAHR+++I+++ VLV G +VE D+ L + LF L+ +++
Sbjct: 1496 ADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1549
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 633 bits (1632), Expect = 0.0
Identities = 415/1334 (31%), Positives = 675/1334 (50%), Gaps = 139/1334 (10%)
Query: 226 EGAR-LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEE------------ 272
+GAR +W+AL AFGR + +++ +LGF+GPL + +V L +
Sbjct: 282 QGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFL 341
Query: 273 ------GQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQ 326
QE L++ + A+ L +L Y + + RGA+ +Y K +
Sbjct: 342 GVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMH 401
Query: 327 LGPSRPPTGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFV 381
L S GE NL+ D+ +L+ F W +P+Q+ + + LLY +GV+ +
Sbjct: 402 LSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSAL 461
Query: 382 GGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGAR 441
G + +LL PV +AT++ + + L++ + R+K E+L GI+++K WE R
Sbjct: 462 IGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTR 521
Query: 442 VEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALA 499
VE R +E+ LR + +++ A+P+ ++ F+ +V + + + F +L+
Sbjct: 522 VETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLS 581
Query: 500 LVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPN-------------HNPQAYYSP- 545
L +L+ PL V+ ++A VS+ ++ FL P + Y
Sbjct: 582 LFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAV 641
Query: 546 -------------DCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISH 592
DC L ++ L+ S + +++ G F+W P G + I+
Sbjct: 642 PLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNIT- 700
Query: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG--------------- 637
+ + +G L IVG+VGCGKSSLL A GE+ ++ G V L
Sbjct: 701 IRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATD 760
Query: 638 --------FGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQT 689
A+Q+PW+ AT+ +NI+F F+ Q YK V+EAC+L D+ ILP GDQT
Sbjct: 761 LDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQT 820
Query: 690 EVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTT 749
++GE+G+ LSGGQR RI++ARA+YQ + LDDP +A+D +++HL+ IL +L
Sbjct: 821 QIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDK 880
Query: 750 R--LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQ 807
R +L TH+ +YL AD ++ M+ G + R G + + + W D +
Sbjct: 881 RTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEK 940
Query: 808 SVQNPEKTKE---GLEEEQSTSGRLLQEESKKEGAVA-----------LHVY-QAYWKAV 852
K E GL S+ LLQ+E ++E A LH + W+A
Sbjct: 941 ETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
Query: 853 GQGLALA-------ILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGL 905
+ L+ A ++FS LL A D+WL+ W +S+ P+ S+
Sbjct: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWT------DSALTLTPAARNCSL-- 1052
Query: 906 FSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGT 965
+ + D Y V+ + + + L+ +V
Sbjct: 1053 -----------------------SQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTG 1089
Query: 966 LQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGL 1025
L+ A LHR LL+R+++AP+ FF TP G ILNRFSSD D +P L L +
Sbjct: 1090 LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLC 1149
Query: 1026 LGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAG 1085
+ LAV+ P L+ L PL+I+ Y +Q+++R +SR+L++L T PL SH A+T+ G
Sbjct: 1150 VSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEG 1209
Query: 1086 LSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVV--SAIAGIAL 1143
L+ +RA RF+++ L + N +A +WL++R++ +GA VV +A+ I+
Sbjct: 1210 LTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISN 1269
Query: 1144 VQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG 1203
H++ + GLVGL L+YAL ++ L+ +V + E L +V+R+ + +G
Sbjct: 1270 SLHRE--LSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEG 1327
Query: 1204 --QPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSL 1261
P + W QG ++ Q++ + Y L L V + PG+K+GI GRTGSGKSS
Sbjct: 1328 LLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSF 1387
Query: 1262 LLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKD 1321
L FR+++ G +++DG+D ++L L LRS+L+II Q+P LFSGT+R NLDP+ D
Sbjct: 1388 SLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSD 1447
Query: 1322 RALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEA 1380
LW+AL+ L V+ ++ GGLD + EGG + S GQRQL CLARA + I +DEA
Sbjct: 1448 STLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEA 1507
Query: 1381 TASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRN 1440
TAS+D T+ +LQ+ + FA++TV+TIAHR++TIL++D V+VL+ G ++E D P L +
Sbjct: 1508 TASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLS 1567
Query: 1441 QPHSLFQQLLQSSQ 1454
+ S+F +++ +
Sbjct: 1568 RKDSVFASFVRADK 1581
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 631 bits (1628), Expect = e-180
Identities = 409/1289 (31%), Positives = 665/1289 (51%), Gaps = 124/1289 (9%)
Query: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQ----------EPLSH 279
+W A+Y AFGR L + + +LGF+GPL +S +V + E Q E LS
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 280 G--LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQA----RGAVLNILYCKALQLGPSRPP 333
L A LA L +LQ + Y VT++ RGA+L ++Y K L+L S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 334 TGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILAL 388
GE NL+ ++ +L+ F W +P+Q+ + + LLY +G + + G + +
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 389 LLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRAR 448
LL P+ IAT++ + + L + R+K E+L GI+++K WE VE R +
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 449 ELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM-GHQLTATKVFTALALVRMLILP 507
EL L+ + +++ AA+P+ + F+T+ G+ L + F +L+L +L+ P
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP 584
Query: 508 LNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPS 567
L V+ ++A +S+ ++ FL ++ + + + + + C +
Sbjct: 585 LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGE-----SSLPFESC-----KKH 634
Query: 568 TVLELHGALFSWDPVGTSLETFISHLEVK--KGMLVGIVGKVGCGKSSLLAAIAGELHRL 625
T + +G FSW G+ L T +S+++++ G L IVG+VGCGKSSLL AI GE+ L
Sbjct: 635 TGVVTNG-YFSW---GSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTL 689
Query: 626 RGHV-------------AVRGLSK-GFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVL 671
G V A R ++ A Q+PW+ AT+ +NI FG F+ Q YK V
Sbjct: 690 EGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVT 749
Query: 672 EACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDAD 731
+AC+L D+ +LP GDQTE+GE+G+ LSGGQR RI +ARA+YQ + LDDP +A+D
Sbjct: 750 DACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIH 809
Query: 732 VANHLLHRCILGMLSYTTR--LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQA 789
+++HL+ IL L R +L TH+ +YL AD ++ M+ G ++R G +I
Sbjct: 810 LSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVE 869
Query: 790 VPKAWA----------ENGQESDSATAQS-----VQNPEKTKEGLEEEQSTSGRLLQEES 834
+ + W E E+D T + + K +E+E E+
Sbjct: 870 LYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD 929
Query: 835 KKEGAVALHV---YQAYWKAVGQG---LALAILFSLLLMQATRNAADWWLSHWISQLKAE 888
+ L ++ W+ + G L + ++FS LL + A D+WL+ W S+
Sbjct: 930 NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSIN 989
Query: 889 NSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAG 948
N+ G +D +Y+ ++ + G
Sbjct: 990 NT-----------------------------------------GKADQTYYVAGFSILCG 1008
Query: 949 VNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACAD 1008
L+ ++ L AA LH LL+++++ P+ FF+ TP G ILNRFS+D D
Sbjct: 1009 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1068
Query: 1009 DSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLG 1068
+P L L + L + ++ P L+ L PL + +Y +Q+++R +S++L+ L
Sbjct: 1069 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELD 1128
Query: 1069 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQ 1128
T PL H ++T GL+ +RA RF++ L L + N SA +WL++R
Sbjct: 1129 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTD 1188
Query: 1129 LMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVE 1188
+GA +V A IA + G +N GLVGL L YAL++T L+ +V + E + +V+
Sbjct: 1189 YLGACIV-LTASIASI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVK 1244
Query: 1189 RLEEYTCDLPQEPQG--QPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGE 1246
++ + + +G P Q+ W +G ++ D+ + Y L L V ++PG+
Sbjct: 1245 KVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQ 1304
Query: 1247 KLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFS 1306
K+GI GRTGSGKSSL L FR+++ G++++DG+D S+L L LRS+L+II Q+P LFS
Sbjct: 1305 KVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFS 1364
Query: 1307 GTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLA 1365
G++R NLDP+ D LW+AL+ L ++ S+ GGLD + EGG + S+GQRQL CLA
Sbjct: 1365 GSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLA 1424
Query: 1366 RALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQ 1425
RA + + IL +DEATAS+D T+ +LQ+ + FA++TV+TIAHR+++I+++ VLV
Sbjct: 1425 RAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFS 1484
Query: 1426 AGRVVELDSPATLRNQPHSLFQQLLQSSQ 1454
G +VE D+ L + LF L+ +++
Sbjct: 1485 EGILVECDTVPNLLAHKNGLFSTLVMTNK 1513
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 620 bits (1599), Expect = e-177
Identities = 388/1192 (32%), Positives = 619/1192 (51%), Gaps = 125/1192 (10%)
Query: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Query: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
Query: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
Query: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
Query: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
+ +++A VSL R+++FL P + G + + + A
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
Query: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
Query: 633 GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
G Q+ WIQ ++R+NILFG + Y+ V++ACAL DL ILP+GD+TE+G
Sbjct: 706 G---SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIG 762
Query: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTR 750
EKGV LSGGQ+ R++LARAVY ++YL DDPL+AVDA V H+ I GML TR
Sbjct: 763 EKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR 822
Query: 751 LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSAT 805
+L TH YL + D +++M G++ G E+L A + A E Q+++
Sbjct: 823 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENG 882
Query: 806 AQSVQNPEKTKEGLE----------------------------EEQSTSGRLLQEESKKE 837
V P K + +E +++ L + E+KKE
Sbjct: 883 VTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKE 942
Query: 838 -------------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQ 884
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 943 ETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD 1002
Query: 885 LKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYA 944
N +QE + L+VY
Sbjct: 1003 -PIVNGTQE-----------------------------------------HTKVRLSVYG 1020
Query: 945 TIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDV 1004
+ + ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++
Sbjct: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
Query: 1005 ACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSREL 1064
D +P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L
Sbjct: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
Query: 1065 RRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLD 1124
+RL S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL
Sbjct: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
Query: 1125 IRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAML 1184
+RL+ +G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +
Sbjct: 1201 VRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
Query: 1185 VSVERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQ 1243
V+VERL+EY+ + P Q Q + W G VEF++ L YR L L + +
Sbjct: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
Query: 1244 PGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPF 1303
GEK+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P
Sbjct: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
Query: 1304 LFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSL 1354
LFSG++R NLDP + D +W +L+ HL + ++++ LD E EGG +L
Sbjct: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1430
Score = 90.5 bits (223), Expect = 1e-17
Identities = 114/500 (22%), Positives = 219/500 (43%), Gaps = 60/500 (12%)
Query: 990 ATPTGRILNRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLL 1042
++ G I+N S D D +I L ++LA L L + +G+ ++L+
Sbjct: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM 476
Query: 1043 LPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEEN 1102
+P ++M + + A + L + + L G+ VL+ F+++
Sbjct: 477 VPVNAVMAMKTKTYQVAHMKSKDNRIKL--------MNEILNGIKVLKLYAWELAFKDKV 528
Query: 1103 LRLLE-----LNQRCQFATSATMQWL--DIRLQLMGAAVVSAIAGIALVQHQQGLANPGL 1155
L + + L + + T W+ + L AV I ++ Q + L
Sbjct: 529 LAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLAL 588
Query: 1156 VGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG---QPLQLGTGW 1212
+ L + L++ L ++SS Q VS++RL + EP +P++ G G
Sbjct: 589 FNI-LRFPLNI---LPMVISSIVQAS---VSLKRLRIFLSHEELEPDSIERRPVKDGGG- 640
Query: 1213 LTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
+ ++ + P L+G+TF + G + +VG+ G GKSSLL L ++
Sbjct: 641 --TNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKV 698
Query: 1273 SGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQ-C 1331
G V + G +A +PQ+ ++ + ++REN+ G + ++++ Q C
Sbjct: 699 EGHVAIKG-------------SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQAC 744
Query: 1332 HL---SEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
L E++ S G E+GE G +LS GQ+Q + LARA+ ++A I D+ ++VD
Sbjct: 745 ALLPDLEILPS--GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 802
Query: 1389 DQLLQQTIC---KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL--RNQPH 1443
+ + + + NKT + + H ++ + D ++V+ G++ E+ S L R+
Sbjct: 803 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
Query: 1444 SLFQQLLQSSQQGVPASLGG 1463
+ F + S++Q A G
Sbjct: 863 AEFLRTYASTEQEQDAEENG 882
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 619 bits (1596), Expect = e-177
Identities = 407/1277 (31%), Positives = 643/1277 (50%), Gaps = 177/1277 (13%)
Query: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Query: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
Query: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
Query: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
Query: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
+ +++A VSL R+++FL P + G + + + A
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
Query: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
Query: 633 GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
G Q+ WIQ ++R+NILFG + Y+ V++ACAL DL ILP+
Sbjct: 706 G---SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS------- 755
Query: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL 752
G R I EK TR+L
Sbjct: 756 --------GDRTEIG-------EK--------------------------------TRIL 768
Query: 753 CTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSATAQ 807
TH YL + D +++M G++ G E+L A + A E Q+++
Sbjct: 769 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVT 828
Query: 808 SVQNPEKTKEGLEE----------------------------EQSTSGRLLQEESKKE-- 837
V P K + +E +++ L + E+KKE
Sbjct: 829 GVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET 888
Query: 838 -----------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLK 886
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 889 WKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD-P 947
Query: 887 AENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATI 946
N +QE + L+VY +
Sbjct: 948 IVNGTQE-----------------------------------------HTKVRLSVYGAL 966
Query: 947 AGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVAC 1006
+ ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++
Sbjct: 967 GISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDT 1026
Query: 1007 ADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRR 1066
D +P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L+R
Sbjct: 1027 VDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKR 1086
Query: 1067 LGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIR 1126
L S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL +R
Sbjct: 1087 LESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVR 1146
Query: 1127 LQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVS 1186
L+ +G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +V+
Sbjct: 1147 LECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1204
Query: 1187 VERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPG 1245
VERL+EY+ + P Q Q + W G VEF++ L YR L L + + G
Sbjct: 1205 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1264
Query: 1246 EKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLF 1305
EK+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P LF
Sbjct: 1265 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1324
Query: 1306 SGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCL 1364
SG++R NLDP + D +W +L+ HL + ++++ LD E EGG +LS+GQRQL+CL
Sbjct: 1325 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL 1384
Query: 1365 ARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVL 1424
ARALL KIL +DEATA+VD +TD L+Q TI +F + TVLTIAHRLNTI++ RV+VL
Sbjct: 1385 ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1444
Query: 1425 QAGRVVELDSPATLRNQ 1441
G + E +P+ L Q
Sbjct: 1445 DKGEIQEYGAPSDLLQQ 1461
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 603 bits (1556), Expect = e-172
Identities = 443/1377 (32%), Positives = 683/1377 (49%), Gaps = 146/1377 (10%)
Query: 158 QEPLLPED--QEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTY 215
Q P PED Q E G ++ S+ ++ W++ L+ RG LR P+D+ L
Sbjct: 189 QPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLR-PKDLWSLGRENSSEE 247
Query: 216 LARVFQAHW----------------------------------QEGAR---LWRALYGAF 238
L + W QEG++ L +A++ F
Sbjct: 248 LVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVF 307
Query: 239 GRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQ 298
+L L ++ + F+ P LLSL + F+ + + P G L A+ + A L + +
Sbjct: 308 HSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFE 367
Query: 299 NQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTGEALNLLGTDSERLLNFAGSF 355
Q Y + + ++ R A+ ++Y K L L G+ +NL+ D +RL
Sbjct: 368 QQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYL 427
Query: 356 HEAWGLPLQLAITLYL-LYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDA 414
+ W LPL + ++ L+Q +G + + + + L L+P+N I+ + +E ++ KD+
Sbjct: 428 NGLW-LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDS 486
Query: 415 RVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVI 474
R +L + +L + IKF GWE A RV R +ELG LR L + + + ++
Sbjct: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546
Query: 475 SIVIFITYVLMGHQ-LTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLD 533
++V+F + L+ + A K F L ++ +L P+ I+ L++A+VS DR+ FL
Sbjct: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606
Query: 534 LPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHL 593
L +P S G A + +H A F+W I+ L
Sbjct: 607 LEEVDPGVVDSSSSGS--------------AAGKDCITIHSATFAWSQESPPCLHRIN-L 651
Query: 594 EVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIR 653
V +G L+ +VG VG GKSSLL+A+ GEL ++ G V++ G QE W+Q ++
Sbjct: 652 TVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG---AVAYVPQEAWVQNTSVV 708
Query: 654 DNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVY 713
+N+ FG+ D + VLEACAL D+ P G T +GE+G+ LSGGQ+ R++LARAVY
Sbjct: 709 ENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVY 768
Query: 714 QEKELYLLDDPLAAVDADVANHLLHRCIL--GMLSYTTRLLCTHRTEYLERADAVLLMEA 771
++ +YLLDDPLAA+DA V H+ ++ I G+L TTR+L TH L +AD ++++
Sbjct: 769 RKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLAN 828
Query: 772 GRLIRAGPPSEILP----LVQAVPKAWAENGQ-ESDSATAQSVQNPEKTKEGL------- 819
G + G E+L LV + +A + E ++ S ++P T G
Sbjct: 829 GAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRE 888
Query: 820 -------EEEQSTS--------------GRLLQEESKKEGAVALHVYQAYWKAVGQGLAL 858
E++++TS G ++S + G V V+ AY +AVG L L
Sbjct: 889 RSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCL 948
Query: 859 AILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNL 918
LF L Q +WLS W A++ + Q + + G+F L + G
Sbjct: 949 YALFLFLCQQVASFCRGYWLSLW-----ADDPAVGGQQTQAALRGGIFGLLGCLQAIG-- 1001
Query: 919 YIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLH 978
++A++A V G +A+ L +RLL
Sbjct: 1002 -----------------------LFASMAAV------------LLGGARASRLLFQRLLW 1026
Query: 979 RVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPW 1038
V+ +P++FF TP G +LNRFS + D +P L LL A GLL + V+ P
Sbjct: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPL 1086
Query: 1039 LLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRF 1098
+ + PL ++Y Q Y SS +LRRL S + S + SH+A+T G +V+RA F
Sbjct: 1087 ATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPF 1146
Query: 1099 EEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGL 1158
+N ++ +QR F +WL ++L+G +V A A A++ + GLVG
Sbjct: 1147 VAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAH--LSAGLVGF 1204
Query: 1159 SLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGG- 1217
S+S AL +T L +V ++T E +VSVER+++Y + P P QGG
Sbjct: 1205 SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQ 1264
Query: 1218 VEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVL 1277
+EF+D L YRP LP A+ GV+F + GEK+GIVGRTG+GKSSL L RL E + G +
Sbjct: 1265 IEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 1324
Query: 1278 LDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVI 1337
+DGV + + L LRS+++IIPQ+P LF G++R NLD H D A+W AL+ L ++
Sbjct: 1325 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALV 1384
Query: 1338 TSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTI 1396
S+ G L + + G LS+GQ+QLLCLARALL +IL +DEATA+VD T+ +Q +
Sbjct: 1385 ASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAML 1444
Query: 1397 CKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
FA TVL IAHRL ++++ RVLV+ G+V E SPA L Q LF +L Q S
Sbjct: 1445 GSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ-KGLFYRLAQES 1500
Score = 79.7 bits (195), Expect = 2e-14
Identities = 77/282 (27%), Positives = 120/282 (42%), Gaps = 29/282 (10%)
Query: 1185 VSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQP 1244
VS +RL + C +P + + A+ P L + V
Sbjct: 596 VSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQ 655
Query: 1245 GEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFL 1304
G L +VG G+GKSSLL L L G V ++G +A +PQE ++
Sbjct: 656 GCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA-------------VAYVPQEAWV 702
Query: 1305 FSGTVREN------LDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLG 1357
+ +V EN LDP L + L+ C L + S G+ +GE G +LS G
Sbjct: 703 QNTSVVENVCFGQELDPPWLER------VLEACALQPDVDSFPEGIHTSIGEQGMNLSGG 756
Query: 1358 QRQLLCLARALLTDAKILCIDEATASVDQKTDQ-LLQQTICK--RFANKTVLTIAHRLNT 1414
Q+Q L LARA+ A + +D+ A++D Q + Q I T + + H L+
Sbjct: 757 QKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHI 816
Query: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQG 1456
+ +D ++VL G + E+ S L + +L L Q+ Q G
Sbjct: 817 LPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 858
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 597 bits (1540), Expect = e-170
Identities = 438/1361 (32%), Positives = 677/1361 (49%), Gaps = 144/1361 (10%)
Query: 172 EDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHW------- 224
E G ++ S+ ++ W++ L+ RG LR P+D+ L L + W
Sbjct: 14 ETGAAFPSKATFWWVSGLVWRGYRRPLR-PKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72
Query: 225 ---------------------------QEGAR---LWRALYGAFGRCYLALGLLKLVGTM 254
QEG++ L +A++ F +L L ++ +
Sbjct: 73 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 132
Query: 255 LGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARG 314
F+ P LLSL + F+ + + P G L A+ + A L + + Q Y + + ++ R
Sbjct: 133 FRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRS 192
Query: 315 AVLNILYCKALQLGPSR---PPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYL 371
A+ ++Y K L L G+ +NL+ D +RL + W LPL + ++
Sbjct: 193 AITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW-LPLVWIVVCFV 251
Query: 372 -LYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIK 430
L+Q +G + + + + L L+P+N I+ + +E ++ KD+R +L + +L + IK
Sbjct: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 311
Query: 431 FCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQ-L 489
F GWE A RV R +ELG LR L + + + ++++V+F + L+ +
Sbjct: 312 FHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 371
Query: 490 TATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGR 549
A K F L ++ +L P+ I+ L++A+VS DR+ FL L +P A S G
Sbjct: 372 NAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSSSSGS 431
Query: 550 LGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGC 609
A + + A F+W I+ L V +G L+ +VG VG
Sbjct: 432 --------------AAGKDCITIQSATFAWSQESPPCLHRIN-LTVPQGCLLAVVGPVGA 476
Query: 610 GKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKE 669
GKSSLL+A+ GEL ++ G V++ G QE W+Q ++ +N+ FG+ D +
Sbjct: 477 GKSSLLSALLGELSKVEGFVSIEG---AVAYVPQEAWVQNTSVVENVCFGQELDPPWLER 533
Query: 670 VLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVD 729
VLEACAL D+ P G T +GE+G+ LSGGQ+ R++LARAVY++ +YLLDDPLAA+D
Sbjct: 534 VLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 593
Query: 730 ADVANHLLHRCIL--GMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILP-- 785
A V H+ ++ I G+L TTR+L TH L +AD ++++ G + G E+L
Sbjct: 594 AHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRK 653
Query: 786 --LVQAVPKAWAENGQ-ESDSATAQSVQNPEKTKEGL--------------EEEQSTS-- 826
LV + +A + E ++ S ++P T G E++++TS
Sbjct: 654 GALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEA 713
Query: 827 ------------GRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAA 874
G ++S + G V V+ AY +AVG L L LF L Q
Sbjct: 714 QTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR 773
Query: 875 DWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSS 934
+WLS W A++ + Q + + G+F L + G
Sbjct: 774 GYWLSLW-----ADDPAVGGQQTQAALRGGIFGLLGCLQAIG------------------ 810
Query: 935 DIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTG 994
++A++A V G +A+ L +RLL V+ +P++FF TP G
Sbjct: 811 -------LFASMAAV------------LLGGARASRLLFQRLLWDVVRSPISFFERTPIG 851
Query: 995 RILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQ 1054
+LNRFS + D +P L LL A GLL + V+ P + + PL ++Y Q
Sbjct: 852 HLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQ 911
Query: 1055 RHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQF 1114
Y SS +LRRL S + S + SH+A+T G +V+RA F +N ++ +QR F
Sbjct: 912 SLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISF 971
Query: 1115 ATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLV 1174
+WL ++L+G +V A A A++ + GLVG S+S AL +T L +V
Sbjct: 972 PRLVADRWLAANVELLGNGLVFAAATCAVLSKAH--LSAGLVGFSVSAALQVTQTLQWVV 1029
Query: 1175 SSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGG-VEFQDVVLAYRPGLPN 1233
++T E +VSVER+++Y + P P QGG +EFQD L YRP LP
Sbjct: 1030 RNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPL 1089
Query: 1234 ALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRS 1293
A+ GV+F + GEK+GIVGRTG+GKSSL L RL E + G + +DGV + + L LRS
Sbjct: 1090 AVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRS 1149
Query: 1294 QLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGR 1352
+++IIPQ+P LF G++R NLD H D A+W AL+ L ++ S+ G L + + G
Sbjct: 1150 RISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGE 1209
Query: 1353 SLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL 1412
LS+GQ+QLLCLARALL +IL +DEATA+VD T+ +Q + FA TVL IAHRL
Sbjct: 1210 DLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRL 1269
Query: 1413 NTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
++++ RVLV+ G+V E SPA L Q LF +L Q S
Sbjct: 1270 RSVMDCARVLVMDKGQVAESGSPAQLLAQ-KGLFYRLAQES 1309
Score = 82.8 bits (203), Expect = 2e-15
Identities = 78/282 (27%), Positives = 121/282 (42%), Gaps = 29/282 (10%)
Query: 1185 VSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQP 1244
VS +RL + C +P + + Q A+ P L + V
Sbjct: 405 VSFDRLVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQ 464
Query: 1245 GEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFL 1304
G L +VG G+GKSSLL L L G V ++G +A +PQE ++
Sbjct: 465 GCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA-------------VAYVPQEAWV 511
Query: 1305 FSGTVREN------LDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLG 1357
+ +V EN LDP L + L+ C L + S G+ +GE G +LS G
Sbjct: 512 QNTSVVENVCFGQELDPPWLER------VLEACALQPDVDSFPEGIHTSIGEQGMNLSGG 565
Query: 1358 QRQLLCLARALLTDAKILCIDEATASVDQKTDQ-LLQQTICK--RFANKTVLTIAHRLNT 1414
Q+Q L LARA+ A + +D+ A++D Q + Q I T + + H L+
Sbjct: 566 QKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHI 625
Query: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQG 1456
+ +D ++VL G + E+ S L + +L L Q+ Q G
Sbjct: 626 LPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 667
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 591 bits (1524), Expect = e-168
Identities = 340/883 (38%), Positives = 504/883 (57%), Gaps = 50/883 (5%)
Query: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATI 652
LE+++G LVGI G VG GK+SL++AI G++ L G +A+ G F Q+ WI AT+
Sbjct: 583 LEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---FAYVAQQAWILNATL 639
Query: 653 RDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAV 712
RDNILFGK +D + Y VL +C L DL+ILP+ D TE+GE+G LSGGQR RI+LARA+
Sbjct: 640 RDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARAL 699
Query: 713 YQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAG 772
Y ++ +Y+LDDPL+A+DA V NH+ + I L T L TH+ +YL D V+ M+ G
Sbjct: 700 YSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEG 759
Query: 773 RLIRAGPPSEILP------------LVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLE 820
+ G E++ L+ P + +E+ + +S KT +
Sbjct: 760 CITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKK 819
Query: 821 EE--QSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA-ADWW 877
E+ + G+L+Q E K +G+V VY Y +A G LA ++ +L ++ A + WW
Sbjct: 820 EKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWW 879
Query: 878 LSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIR 937
LS+WI Q + ++ SM + ++
Sbjct: 880 LSYWIKQGSGNTTVTRGNETSVSDSM---------------------------KDNPHMQ 912
Query: 938 FYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRIL 997
+Y ++YA V + +R V+F GTL+A++ LH L R+L +P+ FF+ TPTGRIL
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 998 NRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHY 1057
NRFS D+ D LPF + + N + + ++ PW L+ + PL I++ +
Sbjct: 973 NRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVS 1032
Query: 1058 RASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATS 1117
R REL+RL ++T SP SH+ ++ GL+ + A F LL+ NQ F +
Sbjct: 1033 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFT 1092
Query: 1118 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSF 1177
M+WL +RL L+ A+++ + ++ H G P GL++SYA+ LTGL V
Sbjct: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMH--GQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
Query: 1178 TQTEAMLVSVERLEEY--TCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNAL 1235
++TEA SVER+ Y T L + + W +G V F++ + YR LP L
Sbjct: 1151 SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVL 1210
Query: 1236 DGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQL 1295
V+F ++P EK+GIVGRTGSGKSSL + LFRL+E S G + +DGV S + LA LRS+L
Sbjct: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
Query: 1296 AIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSL 1354
+IIPQEP LFSGTVR NLDP + + +W AL++ H+ E I + L+ E+ E G +
Sbjct: 1271 SIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1330
Query: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNT 1414
S+G+RQLLC+ARALL KIL +DEATA++D +TD L+Q+TI + FA+ T+LTIAHRL+T
Sbjct: 1331 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHT 1390
Query: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGV 1457
+L SDR++VL G+VVE D+P+ L + S F + +++ V
Sbjct: 1391 VLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
Score = 100 bits (250), Expect = 8e-21
Identities = 109/431 (25%), Positives = 188/431 (43%), Gaps = 41/431 (9%)
Query: 173 DGESWLSRFSYAWLAPLLARGAC--GELRQPQDICRLPHRLQPTYLARVFQAHWQE---- 226
D S +++WL+ L AR A GEL +D+ L R + WQE
Sbjct: 102 DNAGLFSCMTFSWLSSL-ARVAHKKGELSM-EDVWSLSKHESSDVNCRRLERLWQEELNE 159
Query: 227 ---GARLWRALYGAFGRCYLALGLLKLVGTML-GFSGP-LLLSLLVGFLEEGQEPLSHGL 281
A R + F R L L ++ L+ T L GFSGP ++ L+ + + + L + L
Sbjct: 160 VGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSL 219
Query: 282 LYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT-GEALNL 340
L LGL ++ + Y+ ++ RGA+L + + K L+L + + GE +N+
Sbjct: 220 LLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINI 279
Query: 341 LGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVG--GLILALLLVPVNKVIA 398
D +R+ A G P+ L ++Y + + G G + +L P + A
Sbjct: 280 CSNDGQRMFEAAAVGSLLAGGPV--VAILGMIYNVIILGPTGFLGSAVFILFYPA-MMFA 336
Query: 399 TRIMAS-NQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
+R+ A ++ + D RV+ + E+L+ I+ IK W +A V+ R E L
Sbjct: 337 SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAG 396
Query: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVING 517
Y + V + + V+ S+V F ++ +G LTA + FT + + + L P+ +
Sbjct: 397 YFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKS 456
Query: 518 LLEAKVSLDRIQ-LFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGAL 576
L EA V++DR + LFL H + + PA P +E+ A
Sbjct: 457 LSEASVAVDRFKSLFLMEEVH--------------------MIKNKPASPHIKIEMKNAT 496
Query: 577 FSWDPVGTSLE 587
+WD +S++
Sbjct: 497 LAWDSSHSSIQ 507
Score = 85.1 bits (209), Expect = 4e-16
Identities = 57/212 (26%), Positives = 101/212 (47%), Gaps = 15/212 (7%)
Query: 1231 LPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQ 1290
L L + +Q G+ +GI G GSGK+SL+ + + G + + G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
Query: 1291 LRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLD-GELGE 1349
A + Q+ ++ + T+R+N+ + + L C L + + D E+GE
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1350 GGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT-DQLLQQTICKRFANKTVLTI 1408
G +LS GQRQ + LARAL +D I +D+ +++D + + I K +KTVL +
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
Query: 1409 AHRLNTILNSDRVLVLQAGRVVELDSPATLRN 1440
H+L +++ D V+ ++ G + E + L N
Sbjct: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMN 772
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 575 bits (1481), Expect = e-163
Identities = 394/1200 (32%), Positives = 607/1200 (50%), Gaps = 148/1200 (12%)
Query: 335 GEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVN 394
GE LN+L +DS L A +P+ + + +G + G+ + ++ +PV
Sbjct: 218 GEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQ 277
Query: 395 KVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLR 454
+A A + + D RV+ + E L+ IR+IK WE++ ++ R RE L
Sbjct: 278 MFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLE 337
Query: 455 VIKYLDAACVYLWAALPVVISIVIFIT---YVLMGHQLTATKVFTALALVRMLILPLNNF 511
++ + A P+V +I I +T ++L+ +LTA F+ +A+ ++ +
Sbjct: 338 KAGFVQSGNS---ALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAIL 394
Query: 512 PWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLE 571
P+ I + EA VSL R++ L + +P +Y + P +P TVL
Sbjct: 395 PFSIKAMAEANVSLRRMKKILI--DKSPPSYITQ-----------------PEDPDTVLL 435
Query: 572 LHGALFSWDPVGT------------------------------------------SLETF 589
L A +W+ + SL++
Sbjct: 436 LANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSV 495
Query: 590 ISHLE--VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWI 647
+ + V+KG ++GI G VG GKSSLLAA+ G++ +G VAV G +Q+ WI
Sbjct: 496 LHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT---LAYVSQQAWI 552
Query: 648 QFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIA 707
+R+NILFG+ +D Q Y+ + C L DLS LP GD TE+GE+G+ LSGGQR RI+
Sbjct: 553 FHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRIS 612
Query: 708 LARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVL 767
LARAVY +++LYLLDDPL+AVDA V H+ CI L T +L TH+ ++LE D V+
Sbjct: 613 LARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVI 672
Query: 768 LMEAGRLIRAGPPSEILP-------LVQ----------------AVPKAWAENGQESDSA 804
L+E G + G E++ L+ A+ +A+ E+ E +
Sbjct: 673 LLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREED 732
Query: 805 TAQSVQNPEKTK-EGLEEEQSTS--------GRLLQEESKKEGAVALHVYQAYWKAVGQG 855
V P K EG E E + +L+Q ES +EG V Y Y KA G
Sbjct: 733 AGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGY 792
Query: 856 L-ALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFS 914
L +L +F LLM + ++WWL W+ K + Q + + +G +L
Sbjct: 793 LLSLFTVFLFLLMIGSAAFSNWWLGLWLD--KGSRMTCGPQGNRTMCEVGA-----VLAD 845
Query: 915 PGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHR 974
G Y VY + + + +F TL A+++LH
Sbjct: 846 IGQ-------------------HVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHD 886
Query: 975 RLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGS 1034
+ ++L +P++FF+ TPTGR++NRFS D+ D LPF L ++ +L +L +
Sbjct: 887 TVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAA 946
Query: 1035 GLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGA 1094
P +LL++ L++ ++ + R + +EL+++ +++ SP ++H+ ++ GL ++ A G
Sbjct: 947 VFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGK 1006
Query: 1095 TYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPG 1154
+E + L C ++W +R+ ++ + +A LV +
Sbjct: 1007 ----KESCITYHLLYFNC------ALRWFALRMDVLMNILTFTVA--LLVTLSFSSISTS 1054
Query: 1155 LVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGT---G 1211
GLSLSY + L+GLL V + T+T+A SVE L EY E PL++GT
Sbjct: 1055 SKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECT-HPLKVGTCPKD 1113
Query: 1212 WLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEP 1271
W ++G + F+D + YR P LD + +Q G+ +GIVGRTGSGKSSL + LFRL+EP
Sbjct: 1114 WPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEP 1173
Query: 1272 SSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQC 1331
+SG + +D VD L L LR++L +IPQ+P LF GTVR NLDP H D LWQ L++
Sbjct: 1174 ASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERT 1233
Query: 1332 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1390
+ + I + L E+ E G + S+G+RQLLC+ARALL ++KI+ +DEATAS+D KTD
Sbjct: 1234 FMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDT 1293
Query: 1391 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 1450
L+Q TI F TVLTIAHRLNT+LN D VLV++ G+V+E D P L +P S F LL
Sbjct: 1294 LVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLL 1353
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 573 bits (1476), Expect = e-163
Identities = 389/1240 (31%), Positives = 638/1240 (51%), Gaps = 106/1240 (8%)
Query: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Query: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
Query: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
Query: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
Query: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
+ +++A VSL R+++FL P + G + + + A
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
Query: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
Query: 633 GLSKGFGLATQEPWIQFA-TIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEV 691
G++ G Q+ + A + N D L+ + L A + I + +
Sbjct: 706 GVNLSGG---QKQRVSLARAVYSNA------DIYLFDDPLSAVDAHVGKHIF----ENVI 752
Query: 692 GEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRL 751
G KG+ + + RI + ++ L +D + ++ ++ +L
Sbjct: 753 GPKGMLKN---KTRILVTHSM---SYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEF 806
Query: 752 LCTHRTEYLERADAVLLMEAGRLIRAGPPSEI------LPLVQAVPKAWAENGQESDSAT 805
L T+ + E+ DA E G +GP E + + + K S S +
Sbjct: 807 LRTYASTEQEQ-DA---EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYS 862
Query: 806 AQSVQNPEKTKE--GLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFS 863
++ T E E ++ + +L++ + + G V L VY Y KA+G ++ +F
Sbjct: 863 GDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFL 922
Query: 864 LLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVF 923
+ + A+++WLS W N +QE
Sbjct: 923 FMCNHVSALASNYWLSLWTDD-PIVNGTQE------------------------------ 951
Query: 924 PLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMA 983
+ L+VY + + ++ + G + A+ LH LLH +L +
Sbjct: 952 -----------HTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRS 1000
Query: 984 PVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLL 1043
P++FF TP+G ++NRFS ++ D +P ++ + + + ++G V+ P +++
Sbjct: 1001 PMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIII 1060
Query: 1044 PPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENL 1103
PPL ++Y+ VQR Y ASSR+L+RL S++ SP+YSH +TL G+SV+RA RF ++
Sbjct: 1061 PPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSD 1120
Query: 1104 RLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYA 1163
++ NQ+ + + +WL +RL+ +G +V A A++ + GLVGLS+SY+
Sbjct: 1121 LKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYS 1178
Query: 1164 LSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQD 1222
L +T L+ LV ++ E +V+VERL+EY+ + P Q Q + W G VEF++
Sbjct: 1179 LQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRN 1238
Query: 1223 VVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVD 1282
L YR L L + + GEK+GIVGRTG+GKSSL L LFR+ E + G +++DG++
Sbjct: 1239 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1298
Query: 1283 TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-G 1341
+++ L LR ++ IIPQ+P LFSG++R NLDP + D +W +L+ HL + ++++
Sbjct: 1299 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1358
Query: 1342 GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA 1401
LD E EGG +LS+GQRQL+CLARALL KIL +DEATA+VD +TD L+Q TI +F
Sbjct: 1359 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1418
Query: 1402 NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQ 1441
+ TVLTIAHRLNTI++ RV+VL G + E +P+ L Q
Sbjct: 1419 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
Score = 51.2 bits (121), Expect = 7e-06
Identities = 36/140 (25%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 1329 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
K LS ++ M ++G + G +LS GQ+Q + LARA+ ++A I D+ ++VD
Sbjct: 684 KSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 743
Query: 1389 DQLLQQTIC---KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL--RNQPH 1443
+ + + + NKT + + H ++ + D ++V+ G++ E+ S L R+
Sbjct: 744 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 803
Query: 1444 SLFQQLLQSSQQGVPASLGG 1463
+ F + S++Q A G
Sbjct: 804 AEFLRTYASTEQEQDAEENG 823
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 567 bits (1462), Expect = e-161
Identities = 424/1373 (30%), Positives = 673/1373 (49%), Gaps = 142/1373 (10%)
Query: 155 PWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPT 214
P+ +P P Q D S + +WL PL+ + LR D +P P
Sbjct: 73 PFRPKPRFPAPQPL----DNAGLFSYLTVSWLTPLMIQS----LRSRLDENTIP----PL 120
Query: 215 YLARVFQAHWQEGARLWRALYGAFG--RCYLALGLLKLVGTMLGFS-------------G 259
+ + Q RLW G + + L +L+ T L F G
Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
Query: 260 PLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVY----KVTLQARGA 315
P+L+ + LE +E L + +++ +GL L +++ + + ++ R A
Sbjct: 181 PILI--IPKILEYSEEQLGN-VVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAA 237
Query: 316 VLNILYCKALQL-GPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQ 374
V + + K +Q +GEA++ D L F G + PL L L+
Sbjct: 238 VSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYL--FEGVCYG----PLVLITCASLVIC 291
Query: 375 QVGVAFVGGL-----ILALLLVPVNKVIATRIMASNQEMLQH-KDARVKLVTELLSGIRV 428
+ F+ G IL LLV V TR+ Q D R+++ +E+L+ I++
Sbjct: 292 SISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKL 351
Query: 429 IKFCGWEQALGARVEACRARE---LGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM 485
IK WE+ +E R +E L + +++ L + +++ +P V + V + + +
Sbjct: 352 IKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI---IPTVATAVWVLIHTSL 408
Query: 486 GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--DLPNHNPQAYY 543
+LTA+ F+ LA + +L L + P + GL +K ++ R + F + P Q
Sbjct: 409 KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQ 468
Query: 544 SPDCGRL--GAQIKWLLCSDPPAEPSTVLELHGALFSW----------DPVGTSL--ETF 589
P + A + W + LE +G + G SL E
Sbjct: 469 DPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528
Query: 590 ISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQF 649
+L V KGM++G+ G G GKSSLL+AI E+H L G V V+G Q+ WI
Sbjct: 529 KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG---SLAYVPQQAWIVS 585
Query: 650 ATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALA 709
IR+NIL G +D Y +VL C+LN DL +LP GD TE+GE+G+ LSGGQ+ RI+LA
Sbjct: 586 GNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLA 645
Query: 710 RAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLM 769
RAVY ++++YLLDDPL+AVDA V H+ CI L T +L TH+ +YLE ++L+
Sbjct: 646 RAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILL 705
Query: 770 EAGRLIRAGPPSEILP----LVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEE--EQ 823
E G++ G SE++ Q + K E + TA+ + P+ + L E+
Sbjct: 706 ENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEE 765
Query: 824 STSG------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAAD-W 876
S +G +L QEE +EG+++ VY Y +A G + I+F +++ W
Sbjct: 766 SLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFW 825
Query: 877 WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 936
WLS+W+ Q NSS+E+ + + +PQL
Sbjct: 826 WLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL-------------------------- 859
Query: 937 RFYLTVYATIAGVNSLCTLLRAV----LFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
FY VY G+N+L + V +F T +A+ LH +L ++V P++FF+ P
Sbjct: 860 SFYQLVY----GLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP 915
Query: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052
GR+LN F+ D+ D LP L + ++ +L ++ P++LL+ + ++ +
Sbjct: 916 IGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFI 975
Query: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112
++ + +RL + + SPL+SH+ ++L GLS + G T F + RL +
Sbjct: 976 YYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNY 1035
Query: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172
++ +W+ +RL++M V A+A G+ S+ + ++
Sbjct: 1036 LLLFLSSTRWMALRLEIMTNLVTLAVALFVAF---------GISSTPYSFKVMAVNIVLQ 1086
Query: 1173 LVSSFT-------QTEAMLVSVERLEEY----TCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
L SSF +TEA +VER+ +Y + P +G GW G + FQ
Sbjct: 1087 LASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCP--QGWPQHGEIIFQ 1144
Query: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
D + YR P L G+ ++ E +GIVGRTGSGKSSL + LFRL+EP +GR+L+DGV
Sbjct: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
Query: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM- 1340
D + L LRS+L++IPQ+P L SGT+R NLDP H D+ +W AL++ L++ I+
Sbjct: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFP 1264
Query: 1341 GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRF 1400
L ++ E G + S+G+RQLLC+ARA+L ++KI+ IDEATAS+D +TD L+Q+TI + F
Sbjct: 1265 KKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAF 1324
Query: 1401 ANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
TVL IAHR+ T+LN D +LV+ G+VVE D P LR +P SLF L+ ++
Sbjct: 1325 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1377
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 567 bits (1462), Expect = e-161
Identities = 424/1373 (30%), Positives = 673/1373 (49%), Gaps = 142/1373 (10%)
Query: 155 PWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPT 214
P+ +P P Q D S + +WL PL+ + LR D +P P
Sbjct: 73 PFRPKPRFPAPQPL----DNAGLFSYLTVSWLTPLMIQS----LRSRLDENTIP----PL 120
Query: 215 YLARVFQAHWQEGARLWRALYGAFG--RCYLALGLLKLVGTMLGFS-------------G 259
+ + Q RLW G + + L +L+ T L F G
Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
Query: 260 PLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVY----KVTLQARGA 315
P+L+ + LE +E L + +++ +GL L +++ + + ++ R A
Sbjct: 181 PILI--IPKILEYSEEQLGN-VVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAA 237
Query: 316 VLNILYCKALQL-GPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQ 374
V + + K +Q +GEA++ D L F G + PL L L+
Sbjct: 238 VSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYL--FEGVCYG----PLVLITCASLVIC 291
Query: 375 QVGVAFVGGL-----ILALLLVPVNKVIATRIMASNQEMLQH-KDARVKLVTELLSGIRV 428
+ F+ G IL LLV V TR+ Q D R+++ +E+L+ I++
Sbjct: 292 SISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKL 351
Query: 429 IKFCGWEQALGARVEACRARE---LGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM 485
IK WE+ +E R +E L + +++ L + +++ +P V + V + + +
Sbjct: 352 IKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI---IPTVATAVWVLIHTSL 408
Query: 486 GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--DLPNHNPQAYY 543
+LTA+ F+ LA + +L L + P + GL +K ++ R + F + P Q
Sbjct: 409 KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQ 468
Query: 544 SPDCGRL--GAQIKWLLCSDPPAEPSTVLELHGALFSW----------DPVGTSL--ETF 589
P + A + W + LE +G + G SL E
Sbjct: 469 DPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528
Query: 590 ISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQF 649
+L V KGM++G+ G G GKSSLL+AI E+H L G V V+G Q+ WI
Sbjct: 529 KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG---SLAYVPQQAWIVS 585
Query: 650 ATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALA 709
IR+NIL G +D Y +VL C+LN DL +LP GD TE+GE+G+ LSGGQ+ RI+LA
Sbjct: 586 GNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLA 645
Query: 710 RAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLM 769
RAVY ++++YLLDDPL+AVDA V H+ CI L T +L TH+ +YLE ++L+
Sbjct: 646 RAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILL 705
Query: 770 EAGRLIRAGPPSEILP----LVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEE--EQ 823
E G++ G SE++ Q + K E + TA+ + P+ + L E+
Sbjct: 706 ENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEE 765
Query: 824 STSG------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAAD-W 876
S +G +L QEE +EG+++ VY Y +A G + I+F +++ W
Sbjct: 766 SLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFW 825
Query: 877 WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 936
WLS+W+ Q NSS+E+ + + +PQL
Sbjct: 826 WLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL-------------------------- 859
Query: 937 RFYLTVYATIAGVNSLCTLLRAV----LFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
FY VY G+N+L + V +F T +A+ LH +L ++V P++FF+ P
Sbjct: 860 SFYQLVY----GLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP 915
Query: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052
GR+LN F+ D+ D LP L + ++ +L ++ P++LL+ + ++ +
Sbjct: 916 IGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFI 975
Query: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112
++ + +RL + + SPL+SH+ ++L GLS + G T F + RL +
Sbjct: 976 YYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNY 1035
Query: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172
++ +W+ +RL++M V A+A G+ S+ + ++
Sbjct: 1036 LLLFLSSTRWMALRLEIMTNLVTLAVALFVAF---------GISSTPYSFKVMAVNIVLQ 1086
Query: 1173 LVSSFT-------QTEAMLVSVERLEEY----TCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
L SSF +TEA +VER+ +Y + P +G GW G + FQ
Sbjct: 1087 LASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCP--QGWPQHGEIIFQ 1144
Query: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
D + YR P L G+ ++ E +GIVGRTGSGKSSL + LFRL+EP +GR+L+DGV
Sbjct: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
Query: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM- 1340
D + L LRS+L++IPQ+P L SGT+R NLDP H D+ +W AL++ L++ I+
Sbjct: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFP 1264
Query: 1341 GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRF 1400
L ++ E G + S+G+RQLLC+ARA+L ++KI+ IDEATAS+D +TD L+Q+TI + F
Sbjct: 1265 KKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAF 1324
Query: 1401 ANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
TVL IAHR+ T+LN D +LV+ G+VVE D P LR +P SLF L+ ++
Sbjct: 1325 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1377
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 524 bits (1349), Expect = e-148
Identities = 411/1372 (29%), Positives = 647/1372 (47%), Gaps = 178/1372 (12%)
Query: 155 PWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPT 214
P+ +P P Q D S + +WL PL+ + LR D +P P
Sbjct: 73 PFRPKPRFPAPQPL----DNAGLFSYLTVSWLTPLMIQS----LRSRLDENTIP----PL 120
Query: 215 YLARVFQAHWQEGARLWRALYGAFG--RCYLALGLLKLVGTMLGFS-------------G 259
+ + Q RLW G + + L +L+ T L F G
Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
Query: 260 PLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVY----KVTLQARGA 315
P+L+ + LE +E L + +++ +GL L +++ + + ++ R A
Sbjct: 181 PILI--IPKILEYSEEQLGN-VVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAA 237
Query: 316 VLNILYCKALQL-GPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQ 374
V + + K +Q +GEA++ D L F G + PL L L+
Sbjct: 238 VSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYL--FEGVCYG----PLVLITCASLVIC 291
Query: 375 QVGVAFVGGL-----ILALLLVPVNKVIATRIMASNQEMLQH-KDARVKLVTELLSGIRV 428
+ F+ G IL LLV V TR+ Q D R+++ +E+L+ I++
Sbjct: 292 SISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKL 351
Query: 429 IKFCGWEQALGARVEACRARE---LGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM 485
IK WE+ +E R +E L + +++ L + +++ +P V + V + + +
Sbjct: 352 IKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI---IPTVATAVWVLIHTSL 408
Query: 486 GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--DLPNHNPQAYY 543
+LTA+ F+ LA + +L L + P + GL +K ++ R + F + P Q
Sbjct: 409 KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQ 468
Query: 544 SPDCGRL--GAQIKWLLCSDPPAEPSTVLELHGALFSW----------DPVGTSL--ETF 589
P + A + W + LE +G + G SL E
Sbjct: 469 DPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528
Query: 590 ISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQF 649
+L V KGM++G+ G G GKSSLL+AI E+H L G V V+G Q+ WI
Sbjct: 529 KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG---SLAYVPQQAWIVS 585
Query: 650 ATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALA 709
IR+NIL G +D Y +VL C+LN DL +LP GD TE+GE+G+ LSGGQ+ RI+LA
Sbjct: 586 GNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLA 645
Query: 710 RAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLM 769
RAVY ++++YLLDDPL+AVDA V H+ CI L T +L TH+ +YLE ++L+
Sbjct: 646 RAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILL 705
Query: 770 EAGRLIRAGPPSEILP----LVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEE--EQ 823
E G++ G SE++ Q + K E + TA+ + P+ + L E+
Sbjct: 706 ENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEE 765
Query: 824 STSG------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAAD-W 876
S +G +L QEE +EG+++ VY Y +A G + I+F +++ W
Sbjct: 766 SLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFW 825
Query: 877 WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 936
WLS+W+ Q NSS+E+ + + +PQL
Sbjct: 826 WLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL-------------------------- 859
Query: 937 RFYLTVYATIAGVNSLCTLLRAV----LFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
FY VY G+N+L + V +F T +A+ LH +L ++V P++FF+ P
Sbjct: 860 SFYQLVY----GLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP 915
Query: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052
GR+LN F+ D+ D LP L + ++ +L ++ P++LL+ + ++ +
Sbjct: 916 IGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFI 975
Query: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112
++ + +RL + + SPL+SH+ ++L GLS + G T F + RL +
Sbjct: 976 YYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNY 1035
Query: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172
++ +W+ +RL++M V A+A G+ S+ + ++
Sbjct: 1036 LLLFLSSTRWMALRLEIMTNLVTLAVALFVAF---------GISSTPYSFKVMAVNIVLQ 1086
Query: 1173 LVSSFT-------QTEAMLVSVERLEEY----TCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
L SSF +TEA +VER+ +Y + P +G GW G + FQ
Sbjct: 1087 LASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCP--QGWPQHGEIIFQ 1144
Query: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
D + YR P L G+ ++ E +GIVGRTGSGKSSL + LFRL+EP +GR+L+DGV
Sbjct: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
Query: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG 1341
D + L LRS+L++IPQ+P L SGT+R NLDP H D+ +W AL+
Sbjct: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252
Query: 1342 GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA 1401
R LT A I+ IDEATAS+D +TD L+Q+TI + F
Sbjct: 1253 ------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQ 1287
Query: 1402 NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
TVL IAHR+ T+LN D +LV+ G+VVE D P LR +P SLF L+ ++
Sbjct: 1288 GCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1339
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 398 bits (1023), Expect = e-110
Identities = 260/795 (32%), Positives = 410/795 (51%), Gaps = 103/795 (12%)
Query: 695 GVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCT 754
G+T S + A +A+ V K LL LA +D + G ++ TR+L T
Sbjct: 663 GITFSIPEGALVAVVGQVGCGKSS-LLSALLAEMDK----------VEGHVAIKTRILVT 711
Query: 755 HRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSATAQSV 809
H YL + D +++M G++ G E+L A + A E Q+++ V
Sbjct: 712 HSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGV 771
Query: 810 QNPEKTKEGLEE----------------------------EQSTSGRLLQEESKKE---- 837
P K + +E +++ L + E+KKE
Sbjct: 772 SGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK 831
Query: 838 ---------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAE 888
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 832 LMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD-PIV 890
Query: 889 NSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAG 948
N +QE + L+VY +
Sbjct: 891 NGTQE-----------------------------------------HTKVRLSVYGALGI 909
Query: 949 VNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACAD 1008
+ ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++ D
Sbjct: 910 SQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVD 969
Query: 1009 DSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLG 1068
+P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L+RL
Sbjct: 970 SMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLE 1029
Query: 1069 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQ 1128
S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL +RL+
Sbjct: 1030 SVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLE 1089
Query: 1129 LMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVE 1188
+G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +V+VE
Sbjct: 1090 CVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE 1147
Query: 1189 RLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEK 1247
RL+EY+ + P Q Q + W G VEF++ L YR L L + + GEK
Sbjct: 1148 RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEK 1207
Query: 1248 LGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSG 1307
+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P LFSG
Sbjct: 1208 VGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSG 1267
Query: 1308 TVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLAR 1366
++R NLDP + D +W +L+ HL + ++++ LD E EGG +LS+GQRQL+CLAR
Sbjct: 1268 SLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLAR 1327
Query: 1367 ALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQA 1426
ALL KIL +DEATA+VD +TD L+Q TI +F + TVLTIAHRLNTI++ RV+VL
Sbjct: 1328 ALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDK 1387
Query: 1427 GRVVELDSPATLRNQ 1441
G + E +P+ L Q
Sbjct: 1388 GEIQEYGAPSDLLQQ 1402
Score = 212 bits (539), Expect = 2e-54
Identities = 133/420 (31%), Positives = 218/420 (51%), Gaps = 28/420 (6%)
Query: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Query: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
Query: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
Query: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
Query: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
+ +++A VSL R+++FL P + G + + + A
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
Query: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
Score = 73.6 bits (179), Expect = 1e-12
Identities = 60/212 (28%), Positives = 99/212 (46%), Gaps = 15/212 (7%)
Query: 586 LETFISHLEV--KKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG------ 637
L+ + H+ V G VGIVG+ G GKSSL + G + + G++
Sbjct: 1191 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1250
Query: 638 ----FGLATQEPWIQFATIRDNI-LFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
+ Q+P + ++R N+ F + D +++ LE L D +S LP E
Sbjct: 1251 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS-LELAHLKDFVSALPDKLDHECA 1309
Query: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL 752
E G LS GQR + LARA+ ++ ++ +LD+ AAVD + + L+ I T L
Sbjct: 1310 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQFEDCTVLT 1368
Query: 753 CTHRTEYLERADAVLLMEAGRLIRAGPPSEIL 784
HR + V++++ G + G PS++L
Sbjct: 1369 IAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1400
Score = 47.0 bits (110), Expect = 1e-04
Identities = 66/306 (21%), Positives = 125/306 (40%), Gaps = 35/306 (11%)
Query: 990 ATPTGRILNRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLL 1042
++ G I+N S D D +I L ++LA L L + +G+ ++L+
Sbjct: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM 476
Query: 1043 LPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEEN 1102
+P ++M + + A + L + + L G+ VL+ F+++
Sbjct: 477 VPVNAVMAMKTKTYQVAHMKSKDNRIKL--------MNEILNGIKVLKLYAWELAFKDKV 528
Query: 1103 LRLLE-----LNQRCQFATSATMQWL--DIRLQLMGAAVVSAIAGIALVQHQQGLANPGL 1155
L + + L + + T W+ + L AV I ++ Q + L
Sbjct: 529 LAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLAL 588
Query: 1156 VGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG---QPLQLGTGW 1212
+ L + L++ L ++SS Q VS++RL + EP +P++ G G
Sbjct: 589 FNI-LRFPLNI---LPMVISSIVQAS---VSLKRLRIFLSHEELEPDSIERRPVKDGGG- 640
Query: 1213 LTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
+ ++ + P L+G+TF + G + +VG+ G GKSSLL L ++
Sbjct: 641 --TNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKV 698
Query: 1273 SGRVLL 1278
G V +
Sbjct: 699 EGHVAI 704
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 370 bits (949), Expect = e-102
Identities = 266/901 (29%), Positives = 425/901 (47%), Gaps = 113/901 (12%)
Query: 161 LLPEDQE--PEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLAR 218
+LP QE P +D + SR + WL PL G L + LP + +L
Sbjct: 1 MLPVYQEVKPNPLQDA-NLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPED-RSQHLGE 58
Query: 219 VFQAHWQEGA----------RLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVG 268
Q W + L RA+ + + YL LG+ L+ P+ L ++
Sbjct: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIIN 118
Query: 269 FLEE----GQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKA 324
+ E L+ YA L ++ A+L + Y Y V ++ R A+ +++Y KA
Sbjct: 119 YFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKA 178
Query: 325 LQLGP---SRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFV 381
L+L + TG+ +NLL D + H W PLQ LL+ ++G++ +
Sbjct: 179 LRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCL 238
Query: 382 GGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGAR 441
G+ + ++L+P+ + + DAR++ + E+++GIR+IK WE++
Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
Query: 442 VEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALV 501
+ R +E+ ++ L + + + +I V F TYVL+G +TA++VF A+ L
Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
Query: 502 RMLILPLNNF-PWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIK----- 555
+ L + F P I + EA VS+ RIQ FL L + + P G+ ++
Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
Query: 556 WLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLL 615
W S+ P L G F+ V+ G L+ +VG VG GKSSLL
Sbjct: 419 WDKASETPT-------LQGLSFT----------------VRPGELLAVVGPVGAGKSSLL 455
Query: 616 AAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACA 675
+A+ GEL G V+V G +Q+PW+ T+R NILFGK ++ + Y++V++ACA
Sbjct: 456 SAVLGELAPSHGLVSVHGR---IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACA 512
Query: 676 LNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANH 735
L DL +L GD T +G++G TLSGGQ+AR+ LARAVYQ+ ++YLLDDPL+AVDA+V+ H
Sbjct: 513 LKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRH 572
Query: 736 LLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEIL----------- 784
L CI +L +L TH+ +YL+ A +L+++ G++++ G +E L
Sbjct: 573 LFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK 632
Query: 785 --------PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSG--RLLQEES 834
P V P N S+S+ + K+G E Q T L EE+
Sbjct: 633 KDNEESEQPPVPGTPT--LRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEEN 690
Query: 835 KKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA---ADWWLSHWISQLKAENSS 891
+ EG V Y+ Y++A + +F +LL A + A DWWLS+W ++ N
Sbjct: 691 RSEGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLN-- 746
Query: 892 QEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNS 951
+ + GN+ D+ +YL +Y+ +
Sbjct: 747 ------------------VTVNGGGNV------------TEKLDLNWYLGIYSGLTVATV 776
Query: 952 LCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSL 1011
L + R++L + ++ TLH ++ +L APV FF+ P GRILNRFS D+ DD L
Sbjct: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
Query: 1012 P 1012
P
Sbjct: 837 P 837
Score = 110 bits (275), Expect = 1e-23
Identities = 128/515 (24%), Positives = 231/515 (44%), Gaps = 58/515 (11%)
Query: 941 TVYATIAGVNSLCTLLRAVLF--------AAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
T YA A V + CTL+ A+L AG A H + + L T
Sbjct: 133 TAYA-YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHM-IYRKALRLSNMAMGKTT 190
Query: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLG--------SGLPWLLLLLP 1044
TG+I+N S+DV D F L+ L A + + A+L +G+ L++LLP
Sbjct: 191 TGQIVNLLSNDVNKFDQVTVF-LHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP 249
Query: 1045 PLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEE--EN 1102
+Q + LR + + + + G+ +++ F N
Sbjct: 250 --------LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITN 301
Query: 1103 LRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGL-ANPGLVGLSLS 1161
LR E+++ S+ ++ +++ + ++ + V + A+ V ++L
Sbjct: 302 LRKKEISK---ILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
Query: 1162 YALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
A+ LT L S+ + +VS+ R++ + L E + QL + V Q
Sbjct: 359 GAVRLTVTLF-FPSAIERVSEAIVSIRRIQTFL--LLDEISQRNRQLPSDGKKM--VHVQ 413
Query: 1222 DVVLAY-RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDG 1280
D + + L G++F V+PGE L +VG G+GKSSLL + L PS G V + G
Sbjct: 414 DFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG 473
Query: 1281 VDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM 1340
++A + Q+P++FSGT+R N+ ++ + +K C L + + +
Sbjct: 474 -------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLL 520
Query: 1341 GGLDGEL---GEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ-LLQQTI 1396
DG+L G+ G +LS GQ+ + LARA+ DA I +D+ ++VD + + L + I
Sbjct: 521 E--DGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
Query: 1397 CKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1431
C+ K + + H+L + + ++L+L+ G++V+
Sbjct: 579 CQILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 266 bits (680), Expect = 1e-70
Identities = 170/546 (31%), Positives = 291/546 (53%), Gaps = 33/546 (6%)
Query: 933 SSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
SS FY +Y +A R + + + LH ++LH VL AP++ N
Sbjct: 911 SSYYVFY--IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
Query: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052
G ILNRFS D+A DD LP + + ++G +AV+ P++ + P+ + +
Sbjct: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
Query: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112
++ ++ +S++L++L S SP+++HL +L GL LRA G FE + L L+
Sbjct: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
Query: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172
F +T++W +R++++ A+ I+++ +G G VG+ L+ A+++ L
Sbjct: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEG---EGRVGIILTLAMNIMSTLQW 1145
Query: 1173 LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQP----------------------LQLGT 1210
V+S ++++ SV R+ ++ D+P E G+P ++
Sbjct: 1146 AVNSSIDVDSLMRSVSRVFKF-IDMPTE--GKPTKSTKPYKNGQLSKVMIIENSHVKKDD 1202
Query: 1211 GWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 1270
W + G + +D+ Y G L+ ++F + PG+++G++GRTGSGKS+LL RLL
Sbjct: 1203 IWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN 1262
Query: 1271 PSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQ 1330
+ G + +DGV + L Q R +IPQ+ F+FSGT R+NLDP D+ +W+ +
Sbjct: 1263 -TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
Query: 1331 CHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD 1389
L VI G LD L +GG LS G +QL+CLAR++L+ AKIL +DE +A +D T
Sbjct: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTY 1381
Query: 1390 QLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQL 1449
Q++++T+ + FA+ TV+ HR+ +L + LV++ +V + DS L N+ SLF+Q
Sbjct: 1382 QIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNE-RSLFRQA 1440
Query: 1450 LQSSQQ 1455
+ S +
Sbjct: 1441 ISPSDR 1446
Score = 210 bits (535), Expect = 7e-54
Identities = 157/637 (24%), Positives = 298/637 (46%), Gaps = 42/637 (6%)
Query: 176 SWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHW------QEGAR 229
S +S+ ++W P+L +G L + DI ++P L+ + W ++ +
Sbjct: 10 SVVSKLFFSWTRPILRKGYRQRL-ELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPK 68
Query: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLE-EGQEPLSHGLLYALGLA 288
L AL F ++ G+ +G + PLLL ++ + + +E S + +GL
Sbjct: 69 LINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLC 128
Query: 289 GGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGP---SRPPTGEALNLLGTDS 345
++ +L + + ++ + +Q R A+ +++Y K L+L + G+ ++LL +
Sbjct: 129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNL 188
Query: 346 ERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASN 405
+ H W PLQ+A+ + L+++ + + GL ++L + +M
Sbjct: 189 NKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYR 248
Query: 406 QEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLR---VIKYLDAA 462
+ R+ + +E++ I+ +K WE+A+ +E R EL R ++Y +++
Sbjct: 249 DQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSS 308
Query: 463 CVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLEA 521
+ V +S+ + Y L+ + K+FT ++ +L + + FPW + ++
Sbjct: 309 AFFFSGFFVVFLSV---LPYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDS 364
Query: 522 KVSLDRIQLFLDLPNH---------------NPQAYYSPDCGRLGAQIKWLLCSDPPAEP 566
++++IQ FL + N A++ G L + K + +
Sbjct: 365 LGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNG 424
Query: 567 STVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLR 626
L PV + + ++++G L+ + G G GK+SLL I GEL
Sbjct: 425 DDSLFFSNFSLLGTPVLKDI-----NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSE 479
Query: 627 GHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAG 686
G + G +Q WI TI++NI+FG ++D Y+ V++AC L +D+S
Sbjct: 480 GKIKHSGR---ISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536
Query: 687 DQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLS 746
D +GE G+TLSGGQRARI+LARAVY++ +LYLLD P +D + C+ +++
Sbjct: 537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMA 596
Query: 747 YTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEI 783
TR+L T + E+L++AD +L++ G G SE+
Sbjct: 597 NKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
Score = 99.0 bits (245), Expect = 3e-20
Identities = 59/195 (30%), Positives = 102/195 (52%), Gaps = 15/195 (7%)
Query: 1235 LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQ 1294
L + F ++ G+ L + G TG+GK+SLL+V+ LEPS G++ G +
Sbjct: 441 LKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-------------R 487
Query: 1295 LAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDG-ELGEGGRS 1353
++ Q ++ GT++EN+ + + +K C L E I+ D LGEGG +
Sbjct: 488 ISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGIT 547
Query: 1354 LSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD-QLLQQTICKRFANKTVLTIAHRL 1412
LS GQR + LARA+ DA + +D +D T+ ++ + +CK ANKT + + ++
Sbjct: 548 LSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKM 607
Query: 1413 NTILNSDRVLVLQAG 1427
+ +D++L+L G
Sbjct: 608 EHLKKADKILILHEG 622
Score = 73.9 bits (180), Expect = 1e-12
Identities = 98/443 (22%), Positives = 178/443 (40%), Gaps = 37/443 (8%)
Query: 361 LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMA------SNQEMLQ-HKD 413
LPL + + LL +G V ++ + V VI IM ++Q++ Q +
Sbjct: 987 LPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESE 1046
Query: 414 ARVKLVTEL---LSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAAL 470
R + T L L G+ ++ G + +A L YL W +
Sbjct: 1047 GRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFH--KALNLHTANWFLYLSTL---RWFQM 1101
Query: 471 PVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPL-NNFPWVINGLLEAKV---SLD 526
+ + VIF V LT + + ++ L + + + W +N ++ S+
Sbjct: 1102 RIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVS 1161
Query: 527 RIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSL 586
R+ F+D+P S + G K ++ + + + G + D
Sbjct: 1162 RVFKFIDMPTEGKPTK-STKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYT 1220
Query: 587 ETFISHLE-----VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLS------ 635
E + LE + G VG++G+ G GKS+LL+A L G + + G+S
Sbjct: 1221 EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITL 1279
Query: 636 ----KGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEV 691
K FG+ Q+ +I T R N+ + + Q +V + L + P +
Sbjct: 1280 QQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVL 1339
Query: 692 GEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRL 751
+ G LS G + + LAR+V + ++ LLD+P A +D V ++ R + + T +
Sbjct: 1340 VDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVI 1398
Query: 752 LCTHRTEYLERADAVLLMEAGRL 774
LC HR E + L++E ++
Sbjct: 1399 LCEHRIEAMLECQQFLVIEENKV 1421
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 206 bits (523), Expect = 2e-52
Identities = 223/912 (24%), Positives = 405/912 (44%), Gaps = 97/912 (10%)
Query: 592 HLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLA 641
+L+V+ G V +VG GCGKS+ + + G V+V G L + G+
Sbjct: 414 NLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVV 473
Query: 642 TQEPWIQFATIRDNILFGK---TFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTL 698
+QEP + TI +NI +G+ T D ++ K V EA A D + LP T VGE+G L
Sbjct: 474 SQEPVLFATTIAENIRYGRENVTMD-EIEKAVKEANAY-DFIMKLPHKFDTLVGERGAQL 531
Query: 699 SGGQRARIALARAVYQEKELYLLDDPLAAVDAD---VANHLLHRCILGMLSYTTRLLCTH 755
SGGQ+ RIA+ARA+ + ++ LLD+ +A+D + V L + G T ++ H
Sbjct: 532 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGR----TTIVIAH 587
Query: 756 RTEYLERADAVLLMEAGRLIRAGPPSEILP----LVQAVPKAWAENGQESDSATAQSVQN 811
R + AD + + G ++ G E++ + V A N E ++A +S
Sbjct: 588 RLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSE 647
Query: 812 PEKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATR 871
+ + + +S+ R G+ A + +A+ + + + ++ +
Sbjct: 648 IDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKL---- 703
Query: 872 NAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPN 931
N +W +++ + + QP+ + ++FS I VF
Sbjct: 704 NLTEW--PYFVVGVFCAIINGGLQPAFA-----------IIFSK---IIGVFTRIDDPET 747
Query: 932 GSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFN-- 989
+ + ++ + ++ + L+ F L + +L V++F+
Sbjct: 748 KRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDP 807
Query: 990 ATPTGRILNRFSSDVACADDSLPFILNILLANAAGL-LGLLA--VLGSGLPWLLLLLPPL 1046
TG + R ++D A ++ L ++ N A L G++ + G L LLL + P+
Sbjct: 808 KNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPI 867
Query: 1047 SIMYYHVQRHYRASS-----RELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEE 1101
+ V+ + +EL G + + + + + +FE
Sbjct: 868 IAIAGVVEMKMLSGQALKDKKELEGSGKIA--------TEAIENFRTVVSLTQEQKFEHM 919
Query: 1102 NLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIA-----LVQHQ-QGLANPGL 1155
+ L++ R + I A + + AG LV H+ + L
Sbjct: 920 YAQSLQVPYRNSLRKAHIF---GITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLL 976
Query: 1156 VGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQ 1215
V ++ + G +S + + + + + E T L + L T +
Sbjct: 977 VFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKT-PLIDSYSTEGLMPNT---LE 1032
Query: 1216 GGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 1273
G V F +VV Y RP +P L G++ V+ G+ L +VG +G GKS+++ +L R +P +
Sbjct: 1033 GNVTFGEVVFNYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1091
Query: 1274 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENL---DPQGLHKDRALWQALKQ 1330
G+VLLDG + +L + LR+ L I+ QEP LF ++ EN+ D + + +A K+
Sbjct: 1092 GKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKE 1151
Query: 1331 CHLSEVITSMGG-LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD 1389
++ I S+ ++G+ G LS GQ+Q + +ARAL+ IL +DEAT+++D +++
Sbjct: 1152 ANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE 1211
Query: 1390 QLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQL 1449
+++Q+ + K +T + IAHRL+TI N+D ++V Q GRV E H QQL
Sbjct: 1212 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE-----------HGTHQQL 1260
Query: 1450 LQSSQQGVPASL 1461
L +Q+G+ S+
Sbjct: 1261 L--AQKGIYFSM 1270
Score = 122 bits (307), Expect = 2e-27
Identities = 73/221 (33%), Positives = 130/221 (58%), Gaps = 5/221 (2%)
Query: 1215 QGGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 1273
+G +EF++V +Y L G+ VQ G+ + +VG +G GKS+ + ++ RL +P+
Sbjct: 389 KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE 448
Query: 1274 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENL--DPQGLHKDRALWQALKQC 1331
G V +DG D + + LR + ++ QEP LF+ T+ EN+ + + D + +A+K+
Sbjct: 449 GMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDE-IEKAVKEA 507
Query: 1332 HLSEVITSMGG-LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1390
+ + I + D +GE G LS GQ+Q + +ARAL+ + KIL +DEAT+++D +++
Sbjct: 508 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 567
Query: 1391 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1431
++Q + K +T + IAHRL+T+ N+D + G +VE
Sbjct: 568 VVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVE 608
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 187 bits (476), Expect = 5e-47
Identities = 156/516 (30%), Positives = 253/516 (49%), Gaps = 31/516 (6%)
Query: 930 PNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFN 989
P+ + F++ +++ + +++ C R F + + +L +L + FF
Sbjct: 186 PHAFASAIFFMCLFSFGSSLSAGC---RGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQ 242
Query: 990 ATPTGRILNRFSSDVACADDSLPFILNILLAN---AAGLLGLLAVLGSGLPWLLLLLPPL 1046
T TG + +R SSD + LP N+LL + GL G + + L L LL P
Sbjct: 243 ETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPF 302
Query: 1047 SIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLL 1106
+I ++ Y +E+ R ++ + + + GL +R+ GA E E R
Sbjct: 303 TIA---AEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAE---EHEVCRYK 356
Query: 1107 ELNQRCQFA-----TSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLS 1161
E ++C+ + L R+ +G ++ G L Q Q G G + +
Sbjct: 357 EALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCG--LQQMQDGELTQGSLLSFMI 414
Query: 1162 YALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
Y S+ + LV + + + + E++ Y P P L T QG V+FQ
Sbjct: 415 YQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTT---LQGVVKFQ 471
Query: 1222 DVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 1279
DV AY RP P L G+TF ++PGE +VG GSGKS++ +L L +P+ G+VLLD
Sbjct: 472 DVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLD 530
Query: 1280 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLH--KDRALWQALKQCHLSEVI 1337
SQ E L SQ+ + QEP LFSG+VR N+ GL +D + A + H + I
Sbjct: 531 EKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNI-AYGLQSCEDDKVMAAAQAAHADDFI 589
Query: 1338 TSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTI 1396
M G+ ++GE G L+ GQ+Q L +ARAL+ D ++L +DEAT+++D + +Q LQ
Sbjct: 590 QEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWN 649
Query: 1397 CKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVEL 1432
+ ++TVL IAHRL + + ++LVLQ G++ +L
Sbjct: 650 SR--GDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL 683
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/196 (25%), Positives = 95/196 (48%), Gaps = 24/196 (12%)
Query: 595 VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQE 644
++ G + +VG G GKS++ A + G V + L QE
Sbjct: 493 LRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQE 552
Query: 645 PWIQFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQR 703
P + ++R+NI +G ++ + +A +D + + G T+VGEKG L+ GQ+
Sbjct: 553 PVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQK 612
Query: 704 ARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR-----LLCTHRTE 758
R+A+ARA+ ++ + +LD+ +A+D +C + + +R L+ HR +
Sbjct: 613 QRLAIARALVRDPRVLILDEATSALDV--------QCEQALQDWNSRGDRTVLVIAHRLQ 664
Query: 759 YLERADAVLLMEAGRL 774
++RA +L+++ G+L
Sbjct: 665 AVQRAHQILVLQEGKL 680
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 172 bits (435), Expect = 3e-42
Identities = 148/516 (28%), Positives = 252/516 (48%), Gaps = 37/516 (7%)
Query: 956 LRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFIL 1015
+R L + L L +L V FF+ T TG ++NR SSD A S+ L
Sbjct: 231 IRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENL 290
Query: 1016 NILLANAA----GLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLT 1071
+ L A G+ + V + ++L ++PP+SI+ R+ R +L ++ +
Sbjct: 291 SDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLR----KLTKVTQDS 346
Query: 1072 LSPLYSHLADTLAGLSVLRATGATY----RFEEENLRLLELNQRCQFATSATMQWLDIRL 1127
L+ + + + +RA G ++ + +++L ++ FA R
Sbjct: 347 LAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFA----------RA 396
Query: 1128 QLMGAAVVSAIAGIALVQHQQGLA------NPGLVGLSLSYALSLTGLLSGLVSSFTQTE 1181
GA +S + V ++ GL G + L YA + + GL S +++
Sbjct: 397 GFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELM 456
Query: 1182 AMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAY--RPGLPNALDGVT 1239
L + RL E P+ P + + L QG +EF++V AY RP +P D +
Sbjct: 457 KGLGAGGRLWELLEREPKLPFNEGVILNEKSF-QGALEFKNVHFAYPARPEVPIFQD-FS 514
Query: 1240 FCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIP 1299
+ G +VG +GSGKS++L +L RL +P+SG + LDG D QL LRS++ +
Sbjct: 515 LSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVS 574
Query: 1300 QEPFLFSGTVRENL-----DPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSL 1354
QEP LFS ++ EN+ DP + + A ++ + G + +GE G L
Sbjct: 575 QEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLL 634
Query: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNT 1414
S GQ+Q + +ARALL + KIL +DEAT+++D + + L+Q+ + + +TVL IAHRL+T
Sbjct: 635 SGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLST 694
Query: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 1450
I N++ V VL G++ E L ++P+ ++++L+
Sbjct: 695 IKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
Score = 90.1 bits (222), Expect = 1e-17
Identities = 60/206 (29%), Positives = 104/206 (50%), Gaps = 15/206 (7%)
Query: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 642
L + G + +VG G GKS++L+ + G +++ G L G +
Sbjct: 515 LSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVS 574
Query: 643 QEPWIQFATIRDNILFG----KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTL 698
QEP + +I +NI +G + A+ + V E + P G T VGEKGV L
Sbjct: 575 QEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLL 634
Query: 699 SGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTE 758
SGGQ+ RIA+ARA+ + ++ LLD+ +A+DA+ +L+ + ++ T L+ HR
Sbjct: 635 SGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGRTVLVIAHRLS 693
Query: 759 YLERADAVLLMEAGRLIRAGPPSEIL 784
++ A+ V +++ G++ G E+L
Sbjct: 694 TIKNANMVAVLDQGKITEYGKHEELL 719
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 164 bits (415), Expect = 6e-40
Identities = 155/540 (28%), Positives = 260/540 (48%), Gaps = 44/540 (8%)
Query: 948 GVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACA 1007
GV L T VL + + A + R L +L +TFF+A TG++++R ++DV
Sbjct: 186 GVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEF 245
Query: 1008 DDSLPFILNILLANA---AGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSREL 1064
S +++ L + AG L L++L + L LL++ P + V + R+L
Sbjct: 246 KSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALM---GVGTLMGSGLRKL 302
Query: 1065 RRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLD 1124
R ++ + L + +RA R EE LE RC
Sbjct: 303 SRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEAC-RC------------ 349
Query: 1125 IRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTG--LLSGLVSSFTQTEA 1182
R + +G + + G++ + + +G SL LTG L+S LV+S T +
Sbjct: 350 -RAEELGRGI-ALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS 407
Query: 1183 M-------------LVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAY-- 1227
M L + R+ EY P P + L +G V FQ+V +Y
Sbjct: 408 MANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQL-RGSVTFQNVCFSYPC 466
Query: 1228 RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLE 1287
RPG L T + PG+ + +VG++G GK+++ +L R +P++G V+LDG D L+
Sbjct: 467 RPGF-EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLD 525
Query: 1288 LAQLRSQLA-IIPQEPFLFSGTVRENLDPQGLH-KDRALWQALKQCHLSEVITSMG-GLD 1344
+ LR Q+ I QEP LF T+ EN+ L D ++ A ++ + E ITS G +
Sbjct: 526 PSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYN 585
Query: 1345 GELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKT 1404
+GE G +LS GQ+Q L +ARAL+ +L +DEAT+++D ++++++Q+ + + A +T
Sbjct: 586 TVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRT 645
Query: 1405 VLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP 1464
VL IAHRL+T+ + ++V+ GRV E + L + L+ +L++ P + P
Sbjct: 646 VLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK-GGLYAELIRRQALDAPRTAAPP 704
Score = 94.4 bits (233), Expect = 7e-19
Identities = 147/602 (24%), Positives = 248/602 (41%), Gaps = 86/602 (14%)
Query: 231 WRALYGAFGRCYLALGL---LKLVGTMLGFSGPLLLSLLV------------GFLEEGQE 275
W+ + L LG+ L L ++ PLLL LV F+ E Q
Sbjct: 117 WKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQN 176
Query: 276 PLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTG 335
+H LL G+ G G ++ + E ++ + R A+ + L + + + TG
Sbjct: 177 LSTH-LLILYGVQGLLTFGYLVLLSHVGE--RMAVDMRRALFSSLLRQDITFFDANK-TG 232
Query: 336 EALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNK 395
+ ++ L TD + F SF L+ + + + +L ++ P
Sbjct: 233 QLVSRLTTDVQE---FKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALM 289
Query: 396 VIATRIMASNQEML----QHKDARVKLVT-ELLSGIRVIKFCGWEQA----LGARVEACR 446
+ T +M S L Q + AR V E L +R ++ EQ GA +EACR
Sbjct: 290 GVGT-LMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACR 348
Query: 447 AR--ELGR----LRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALAL 500
R ELGR + + + C+ V+ + ++ G QLT + + L
Sbjct: 349 CRAEELGRGIALFQGLSNIAFNCM--------VLGTLFIGGSLVAGQQLTGGDLMSFLVA 400
Query: 501 VRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCS 560
+ + + N + ++ + R+ ++ L NP C L C
Sbjct: 401 SQTVQRSMANLSVLFGQVVRGLSAGARVFEYMAL---NP-------CIPLSGG-----CC 445
Query: 561 DPPAEPSTVLELHGALFSWD--PVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAI 618
P + + FS+ P L+ F L + G +V +VG+ G GK+++ + +
Sbjct: 446 VPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFT--LTLPPGKIVALVGQSGGGKTTVASLL 503
Query: 619 AGELHRLRGHVAVRGLS-----------KGFGLATQEPWIQFATIRDNILFGK--TFDAQ 665
G V + G + G +QEP + TI +NI FGK D +
Sbjct: 504 ERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEE 563
Query: 666 LYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPL 725
+Y EA A ++ ++ P G T VGE+G TLSGGQ+ R+A+ARA+ ++ + +LD+
Sbjct: 564 VYTAAREANA-HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEAT 622
Query: 726 AAVDAD---VANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSE 782
+A+DA+ V L R G T L+ HR + A +++M GR+ AG E
Sbjct: 623 SALDAESERVVQEALDRASAG----RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEE 678
Query: 783 IL 784
+L
Sbjct: 679 LL 680
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B isoform
2 [Homo sapiens]
Length = 653
Score = 162 bits (411), Expect = 2e-39
Identities = 140/474 (29%), Positives = 227/474 (47%), Gaps = 29/474 (6%)
Query: 930 PNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFN 989
P+ + F++ +++ + +++ C R F + + +L +L + FF
Sbjct: 186 PHAFASAIFFMCLFSFGSSLSAGC---RGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQ 242
Query: 990 ATPTGRILNRFSSDVACADDSLPFILNILLAN---AAGLLGLLAVLGSGLPWLLLLLPPL 1046
T TG + +R SSD + LP N+LL + GL G + + L L LL P
Sbjct: 243 ETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPF 302
Query: 1047 SIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLL 1106
+I ++ Y +E+ R ++ + + + GL +R+ GA E E R
Sbjct: 303 TIA---AEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAE---EHEVCRYK 356
Query: 1107 ELNQRCQFA-----TSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLS 1161
E ++C+ + L R+ +G ++ G L Q Q G G + +
Sbjct: 357 EALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCG--LQQMQDGELTQGSLLSFMI 414
Query: 1162 YALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
Y S+ + LV + + + + E++ Y P P L T QG V+FQ
Sbjct: 415 YQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTT---LQGVVKFQ 471
Query: 1222 DVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 1279
DV AY RP P L G+TF ++PGE +VG GSGKS++ +L L +P+ G+VLLD
Sbjct: 472 DVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLD 530
Query: 1280 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLH--KDRALWQALKQCHLSEVI 1337
SQ E L SQ+ + QEP LFSG+VR N+ GL +D + A + H + I
Sbjct: 531 EKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNI-AYGLQSCEDDKVMAAAQAAHADDFI 589
Query: 1338 TSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1390
M G+ ++GE G L+ GQ+Q L +ARAL+ D ++L +DEAT+++D + +Q
Sbjct: 590 QEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
Score = 57.0 bits (136), Expect = 1e-07
Identities = 39/146 (26%), Positives = 72/146 (49%), Gaps = 11/146 (7%)
Query: 595 VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQE 644
++ G + +VG G GKS++ A + G V + L QE
Sbjct: 493 LRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQE 552
Query: 645 PWIQFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQR 703
P + ++R+NI +G ++ + +A +D + + G T+VGEKG L+ GQ+
Sbjct: 553 PVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQK 612
Query: 704 ARIALARAVYQEKELYLLDDPLAAVD 729
R+A+ARA+ ++ + +LD+ +A+D
Sbjct: 613 QRLAIARALVRDPRVLILDEATSALD 638
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 154 bits (389), Expect = 6e-37
Identities = 153/551 (27%), Positives = 255/551 (46%), Gaps = 37/551 (6%)
Query: 903 MGLFSPQLLLFSPGNLYIPVFP---LPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAV 959
+ LF ++L S G + IP F +GS+D + + S+ T+ AV
Sbjct: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD------TFTRNLTLMSILTIASAV 300
Query: 960 LFAAG------TL-QAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLP 1012
L G T+ + L + VL FF TG I++R + D + DSL
Sbjct: 301 LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS 360
Query: 1013 FILNILLANAAGLLGLLAVLGSGLPWL----LLLLPPLSIMYYHVQRHYRASSRELRRLG 1068
L++ L L LL ++ G L L+ LP L ++ V + Y+ ++R
Sbjct: 361 ENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL 420
Query: 1069 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQ 1128
+ + L+ S G +F E+ + LNQ+ A + I
Sbjct: 421 AKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGM 480
Query: 1129 LMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVE 1188
L+ ++ G LV G + G + + Y + T + L+S + + + + S E
Sbjct: 481 LLKVGIL--YIGGQLVT--SGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSE 536
Query: 1189 RLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNAL--DGVTFCVQPGE 1246
++ EY L + P+ P L T +G V+FQDV AY P P+ L G+TF ++PGE
Sbjct: 537 KIFEY---LDRTPRCPPSGLLTPLHLEGLVQFQDVSFAY-PNRPDVLVLQGLTFTLRPGE 592
Query: 1247 KLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFS 1306
+VG GSGKS++ +L L +P+ G++LLDG Q E L Q+A + QEP +F
Sbjct: 593 VTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFG 652
Query: 1307 GTVRENLDPQGLHKDRALWQ----ALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLL 1362
+++EN+ GL + + + A+K S + G D E+ E G LS GQRQ +
Sbjct: 653 RSLQENI-AYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV 711
Query: 1363 CLARALLTDAKILCIDEATASVDQKTDQLLQQTICK--RFANKTVLTIAHRLNTILNSDR 1420
LARAL+ +L +D+AT+++D + ++Q + + +++VL I L+ + +D
Sbjct: 712 ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 771
Query: 1421 VLVLQAGRVVE 1431
+L L+ G + E
Sbjct: 772 ILFLEGGAIRE 782
Score = 73.9 bits (180), Expect = 1e-12
Identities = 58/205 (28%), Positives = 98/205 (47%), Gaps = 17/205 (8%)
Query: 595 VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQE 644
++ G + +VG G GKS++ A + G + + G L + QE
Sbjct: 588 LRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQE 647
Query: 645 PWIQFATIRDNILFGKTFDAQLYKEVLEACALNDD----LSILPAGDQTEVGEKGVTLSG 700
P + ++++NI +G T + E + A A+ +S LP G TEV E G LSG
Sbjct: 648 PQVFGRSLQENIAYGLTQKPTM--EEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSG 705
Query: 701 GQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYT-TRLLCTHRTEY 759
GQR +ALARA+ ++ + +LDD +A+DA+ + Y+ + LL T
Sbjct: 706 GQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSL 765
Query: 760 LERADAVLLMEAGRLIRAGPPSEIL 784
+E+AD +L +E G + G +++
Sbjct: 766 VEQADHILFLEGGAIREGGTHQQLM 790
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 151 bits (382), Expect = 4e-36
Identities = 141/540 (26%), Positives = 251/540 (46%), Gaps = 60/540 (11%)
Query: 952 LCTLLRAVLFAAGTLQAAATLH--------RRLLHRVLMAPVT-FFNATPTGRILNRFSS 1002
+C L FAAG TL R L R L++ T FF+ TG +++R +S
Sbjct: 232 VCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTS 291
Query: 1003 DVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLP----PLSIMYYHVQ-RHY 1057
D D + +N+ L N + G++ + S L W L L+ P+ +M ++ ++Y
Sbjct: 292 DTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS-LSWQLSLVTFMGFPIIMMVSNIYGKYY 350
Query: 1058 RASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATS 1117
+ S+E++ L+ + +T++ + +R+ E LR L+ + +
Sbjct: 351 KRLSKEVQN----ALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
Query: 1118 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLV--GLSLSYAL----------S 1165
A + + G+ + + ++++ + L G + G +++ + S
Sbjct: 407 AAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMES 461
Query: 1166 LTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLT----QGGVEFQ 1221
+ + SGL+ E + ++R QP + G L +G V+F+
Sbjct: 462 VGSVYSGLMQGVGAAEKVFEFIDR--------------QPTMVHDGSLAPDHLEGRVDFE 507
Query: 1222 DVVLAYRPGL-PNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDG 1280
+V YR L V+F + PG+ +VG +GSGKSS + +L GRVLLDG
Sbjct: 508 NVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDG 567
Query: 1281 VDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK---DRALWQALKQCHLSEVI 1337
S + L ++++ QEP LF+ ++ +N+ GL + + A K ++
Sbjct: 568 KPISAYDHKYLHRVISLVSQEPVLFARSITDNIS-YGLPTVPFEMVVEAAQKANAHGFIM 626
Query: 1338 TSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTIC 1397
G E GE G LS GQ+Q + +ARAL+ + +L +DEAT+++D +++ L+QQ I
Sbjct: 627 ELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIH 686
Query: 1398 KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGV 1457
TVL IAHRL+T+ ++ ++VL GRVV+ + L Q L+ +L+Q G+
Sbjct: 687 GNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLGL 745
Score = 91.7 bits (226), Expect = 5e-18
Identities = 60/198 (30%), Positives = 102/198 (51%), Gaps = 12/198 (6%)
Query: 598 GMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQEPWI 647
G + +VG G GKSS + + G V + G L + L +QEP +
Sbjct: 532 GKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVL 591
Query: 648 QFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
+I DNI +G T ++ E + + + L G TE GEKG LSGGQ+ R+
Sbjct: 592 FARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRV 651
Query: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAV 766
A+ARA+ + + +LD+ +A+DA+ + +L+ + I G L T L+ HR +E A +
Sbjct: 652 AMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLI 710
Query: 767 LLMEAGRLIRAGPPSEIL 784
++++ GR+++ G ++L
Sbjct: 711 VVLDKGRVVQQGTHQQLL 728
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 151 bits (382), Expect = 4e-36
Identities = 141/540 (26%), Positives = 251/540 (46%), Gaps = 60/540 (11%)
Query: 952 LCTLLRAVLFAAGTLQAAATLH--------RRLLHRVLMAPVT-FFNATPTGRILNRFSS 1002
+C L FAAG TL R L R L++ T FF+ TG +++R +S
Sbjct: 232 VCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTS 291
Query: 1003 DVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLP----PLSIMYYHVQ-RHY 1057
D D + +N+ L N + G++ + S L W L L+ P+ +M ++ ++Y
Sbjct: 292 DTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS-LSWQLSLVTFMGFPIIMMVSNIYGKYY 350
Query: 1058 RASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATS 1117
+ S+E++ L+ + +T++ + +R+ E LR L+ + +
Sbjct: 351 KRLSKEVQN----ALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
Query: 1118 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLV--GLSLSYAL----------S 1165
A + + G+ + + ++++ + L G + G +++ + S
Sbjct: 407 AAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMES 461
Query: 1166 LTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLT----QGGVEFQ 1221
+ + SGL+ E + ++R QP + G L +G V+F+
Sbjct: 462 VGSVYSGLMQGVGAAEKVFEFIDR--------------QPTMVHDGSLAPDHLEGRVDFE 507
Query: 1222 DVVLAYRPGL-PNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDG 1280
+V YR L V+F + PG+ +VG +GSGKSS + +L GRVLLDG
Sbjct: 508 NVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDG 567
Query: 1281 VDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK---DRALWQALKQCHLSEVI 1337
S + L ++++ QEP LF+ ++ +N+ GL + + A K ++
Sbjct: 568 KPISAYDHKYLHRVISLVSQEPVLFARSITDNIS-YGLPTVPFEMVVEAAQKANAHGFIM 626
Query: 1338 TSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTIC 1397
G E GE G LS GQ+Q + +ARAL+ + +L +DEAT+++D +++ L+QQ I
Sbjct: 627 ELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIH 686
Query: 1398 KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGV 1457
TVL IAHRL+T+ ++ ++VL GRVV+ + L Q L+ +L+Q G+
Sbjct: 687 GNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLGL 745
Score = 91.7 bits (226), Expect = 5e-18
Identities = 60/198 (30%), Positives = 102/198 (51%), Gaps = 12/198 (6%)
Query: 598 GMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQEPWI 647
G + +VG G GKSS + + G V + G L + L +QEP +
Sbjct: 532 GKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVL 591
Query: 648 QFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
+I DNI +G T ++ E + + + L G TE GEKG LSGGQ+ R+
Sbjct: 592 FARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRV 651
Query: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAV 766
A+ARA+ + + +LD+ +A+DA+ + +L+ + I G L T L+ HR +E A +
Sbjct: 652 AMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLI 710
Query: 767 LLMEAGRLIRAGPPSEIL 784
++++ GR+++ G ++L
Sbjct: 711 VVLDKGRVVQQGTHQQLL 728
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,621,781
Number of Sequences: 37866
Number of extensions: 2682141
Number of successful extensions: 8433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 7697
Number of HSP's gapped (non-prelim): 355
length of query: 1464
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1349
effective length of database: 13,892,928
effective search space: 18741559872
effective search space used: 18741559872
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.