Guide to the Human Genome
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Search of human proteins with 120433600

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
         (676 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...  1345   0.0  
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...  1332   0.0  
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   847   0.0  
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   847   0.0  
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    832   0.0  
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    598   e-171
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   315   7e-86
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    308   1e-83
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   191   1e-48
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   186   8e-47
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   181   2e-45
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   181   3e-45
gi|27886653 potassium voltage-gated channel, subfamily H, member...   163   4e-40
gi|13540549 potassium voltage-gated channel, subfamily H, member...   162   9e-40
gi|26051273 voltage-gated potassium channel, subfamily H, member...   157   2e-38
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   157   2e-38
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   155   9e-38
gi|27886667 potassium voltage-gated channel, subfamily H, member...   153   4e-37
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   153   6e-37
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   152   7e-37
gi|22024390 potassium voltage-gated channel, subfamily H, member...   150   4e-36
gi|27886648 potassium voltage-gated channel, subfamily H, member...   148   2e-35
gi|27437001 potassium voltage-gated channel, subfamily H, member...   147   4e-35
gi|27886651 potassium voltage-gated channel, subfamily H, member...   143   6e-34
gi|26051271 voltage-gated potassium channel, subfamily H, member...   138   2e-32
gi|27886646 potassium voltage-gated channel, subfamily H, member...   133   6e-31
gi|27886665 potassium voltage-gated channel, subfamily H, member...    93   7e-19
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H...    44   5e-04
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho...    44   5e-04
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]      42   0.001

>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score = 1345 bits (3481), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
           MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS
Sbjct: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60

Query: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
           GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN
Sbjct: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120

Query: 121 VGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSE 180
           VGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSE
Sbjct: 121 VGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSE 180

Query: 181 YLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVP 240
           YLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVP
Sbjct: 181 YLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVP 240

Query: 241 TDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNA 300
           TDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNA
Sbjct: 241 TDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNA 300

Query: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360
           CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY
Sbjct: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360

Query: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420
           LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI
Sbjct: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420

Query: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480
           RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL
Sbjct: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480

Query: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540
           RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS
Sbjct: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540

Query: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAR 600
           KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAR
Sbjct: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAR 600

Query: 601 AGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLA 660
           AGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLA
Sbjct: 601 AGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLA 660

Query: 661 DGEVPGDATKTEDKQQ 676
           DGEVPGDATKTEDKQQ
Sbjct: 661 DGEVPGDATKTEDKQQ 676


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score = 1332 bits (3447), Expect = 0.0
 Identities = 675/694 (97%), Positives = 675/694 (97%), Gaps = 18/694 (2%)

Query: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
           MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS
Sbjct: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60

Query: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
           GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN
Sbjct: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120

Query: 121 VGSQEPADRGR------------------RKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 162
           VGSQEPADRGR                   KKTKKKDAIVVDPSSNLYYRWLTAIALPVF
Sbjct: 121 VGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 180

Query: 163 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 222
           YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW
Sbjct: 181 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 240

Query: 223 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 282
           QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM
Sbjct: 241 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 300

Query: 283 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 342
           FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST
Sbjct: 301 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 360

Query: 343 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 402
           LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI
Sbjct: 361 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 420

Query: 403 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 462
           KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV
Sbjct: 421 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 480

Query: 463 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 522
           RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV
Sbjct: 481 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 540

Query: 523 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 582
           LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE
Sbjct: 541 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 600

Query: 583 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 642
           KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ
Sbjct: 601 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 660

Query: 643 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 676
           RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
Sbjct: 661 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 694


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  847 bits (2189), Expect = 0.0
 Identities = 424/677 (62%), Positives = 524/677 (77%), Gaps = 19/677 (2%)

Query: 4   INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63
           INTQ S  +  ++ V   ++++ R ENG   + S  ++++S  +     E+       +G
Sbjct: 79  INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 133

Query: 64  SFTGQGIAR---LSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
           SF+ + + +     R  +L    A  +V++         ++ +  + K+  S + N   N
Sbjct: 134 SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKN 193

Query: 121 VGSQEPADRGRRKKTK-----------KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 169
              ++   + + KK K           KK+ +V+DPS N YY WL  I LPV YNW ++I
Sbjct: 194 DPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 253

Query: 170 CRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTT 229
            RACFDELQS+YL  WL+LDY +D++Y++D+ VR RTG+LEQGL+V +  +L   YK+  
Sbjct: 254 ARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNL 313

Query: 230 QFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLV 289
           QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNYPN+FRI NLV
Sbjct: 314 QFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLV 373

Query: 290 LYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIG 349
           +YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLYWSTLTLTTIG
Sbjct: 374 MYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIG 433

Query: 350 ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFR 409
           ETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+ID+IKQYM FR
Sbjct: 434 ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFR 493

Query: 410 KVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCE 469
            V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTLKKVRIF DCE
Sbjct: 494 NVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCE 553

Query: 470 AGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYF 529
           AGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQFVVLSDGSYF
Sbjct: 554 AGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYF 613

Query: 530 GEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILM 589
           GEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK  LEEKG+QILM
Sbjct: 614 GEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 673

Query: 590 KDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLES 649
           KD L+D  +A AG+DPKDLEEKV ++  S+D LQTRFAR+LAEY + Q K+KQRL+++E 
Sbjct: 674 KDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEK 733

Query: 650 QVKGGGDKPLADGEVPG 666
            +K   D   +  E PG
Sbjct: 734 FLKPLIDTEFSSIEGPG 750


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  847 bits (2189), Expect = 0.0
 Identities = 424/677 (62%), Positives = 524/677 (77%), Gaps = 19/677 (2%)

Query: 4   INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63
           INTQ S  +  ++ V   ++++ R ENG   + S  ++++S  +     E+       +G
Sbjct: 10  INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 64

Query: 64  SFTGQGIAR---LSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
           SF+ + + +     R  +L    A  +V++         ++ +  + K+  S + N   N
Sbjct: 65  SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKN 124

Query: 121 VGSQEPADRGRRKKTK-----------KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 169
              ++   + + KK K           KK+ +V+DPS N YY WL  I LPV YNW ++I
Sbjct: 125 DPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 184

Query: 170 CRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTT 229
            RACFDELQS+YL  WL+LDY +D++Y++D+ VR RTG+LEQGL+V +  +L   YK+  
Sbjct: 185 ARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNL 244

Query: 230 QFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLV 289
           QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNYPN+FRI NLV
Sbjct: 245 QFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLV 304

Query: 290 LYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIG 349
           +YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLYWSTLTLTTIG
Sbjct: 305 MYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIG 364

Query: 350 ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFR 409
           ETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+ID+IKQYM FR
Sbjct: 365 ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFR 424

Query: 410 KVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCE 469
            V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTLKKVRIF DCE
Sbjct: 425 NVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCE 484

Query: 470 AGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYF 529
           AGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQFVVLSDGSYF
Sbjct: 485 AGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYF 544

Query: 530 GEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILM 589
           GEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK  LEEKG+QILM
Sbjct: 545 GEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 604

Query: 590 KDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLES 649
           KD L+D  +A AG+DPKDLEEKV ++  S+D LQTRFAR+LAEY + Q K+KQRL+++E 
Sbjct: 605 KDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEK 664

Query: 650 QVKGGGDKPLADGEVPG 666
            +K   D   +  E PG
Sbjct: 665 FLKPLIDTEFSSIEGPG 681


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  832 bits (2150), Expect = 0.0
 Identities = 421/666 (63%), Positives = 517/666 (77%), Gaps = 23/666 (3%)

Query: 3   KINTQYSHPSRTHLK-----VKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGL 57
           K N   S P+  H       +K + +D +R     SR HS++++ +S        E + L
Sbjct: 4   KTNGVKSSPANNHNHHAPPAIKANGKDDHRTS---SRPHSAADDDTS-------SELQRL 53

Query: 58  ADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
           AD         G  R+ RL+ ++R WA ++   ++  PDSF +RFRG EL+ V++QE + 
Sbjct: 54  ADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDG 113

Query: 118 QANVGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDEL 177
           +   G ++  D+G +KK    +  V+DP+ + YY WL  IA+PV YNW LL+ RACF +L
Sbjct: 114 K---GDKDGEDKGTKKKF---ELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDL 167

Query: 178 QSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLS 237
           Q  Y ++WLVLDY +DV+Y+ D+ +R RTGFLEQGL+V DT +L  +Y  T QFKLDV S
Sbjct: 168 QKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVAS 227

Query: 238 LVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIH 297
           ++PTDL Y  V  + PEVRFNRLL F+R+FEFFDRTETRTNYPN+FRI NLVLYIL+IIH
Sbjct: 228 IIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIH 287

Query: 298 WNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKD 357
           WNACIY+AISK IGFG D+WVYPNI+ PE+G L+R+YIY LYWSTLTLTTIGETPPPVKD
Sbjct: 288 WNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKD 347

Query: 358 EEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLET 417
           EEYLFV+ DFL+GVLIFATIVGNVGSMISNMNA+RAEFQAKID++K YMQFRKV+K +E 
Sbjct: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407

Query: 418 RVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELV 477
           +VIRWFDYLW NKKTVDE+E+LK+LP KL+AEIAINVHL TLKKVRIF DCEAGLLVELV
Sbjct: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467

Query: 478 LKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNI 537
           LKLRP VFSPGDYIC+KGDIGKEMYII EGKLAVVADDGVTQ+ +LS GS FGEISILNI
Sbjct: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527

Query: 538 KGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 597
           KGSK GNRRTANIRS+GYSDLFCLSKDDLMEA+TEYP+AKK LEE+GR+ILMK+ L+DE 
Sbjct: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDEN 587

Query: 598 LARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVK-GGGD 656
                 +  D++EK+ QL ++++TL TRF RLLAEY   Q K+KQR++ LE+++K    D
Sbjct: 588 EVATSME-VDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNED 646

Query: 657 KPLADG 662
             L+DG
Sbjct: 647 DYLSDG 652


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  598 bits (1542), Expect = e-171
 Identities = 288/534 (53%), Positives = 396/534 (74%), Gaps = 9/534 (1%)

Query: 142 VVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 201
           V+DPS + YY WL  +  PV YN  +L+CRACF +LQ  YL+ WLVLDY++D+LY+LD++
Sbjct: 26  VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85

Query: 202 VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLL 261
           VR  TGFLEQG++V D  R+   Y  T  F LD+ SL+PTD+ Y+++G + P +R NR L
Sbjct: 86  VRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFL 145

Query: 262 KFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPN 321
           +  RLFE FDRTETRT YPN FRI  L+LYI ++IHWN+C+YFA+S+++GFG D+WVYP+
Sbjct: 146 RAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPD 205

Query: 322 ISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNV 381
            + P   RL R+Y+YS Y+STL LTT+G+TPPP ++EEYLF+V DFL+ V+ FATI+G++
Sbjct: 206 PAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSM 265

Query: 382 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 441
            S+I NMN + A F      +K+YM+ + V + LE RVI W+ +L  NKK  +E  +L+ 
Sbjct: 266 SSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQH 325

Query: 442 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 501
           LP++L+AE+A++VHL TL +V+IFQ+CEA LL ELVLKL+P  +SPG+Y+C+KGDIG+EM
Sbjct: 326 LPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEM 385

Query: 502 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
           YII EG+LAVVADDG+TQ+ VL  G YFGEISI+NIKG+ SGNRRTANI+S+GYSDLFCL
Sbjct: 386 YIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCL 445

Query: 562 SKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAG-ADPKDLEEKVEQLGSSLD 620
           SK+DL E L+EYP+A+  +EEKGR+IL+K N +D     A  A  +  E ++  L   LD
Sbjct: 446 SKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLD 505

Query: 621 TLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDK 674
            LQT+FARLLAE  ++ +K+  R+ +LE Q +        +  +P D  + +D+
Sbjct: 506 DLQTKFARLLAELESSALKIAYRIERLEWQTR--------EWPMPEDLAEADDE 551


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  315 bits (808), Expect = 7e-86
 Identities = 165/458 (36%), Positives = 272/458 (59%), Gaps = 15/458 (3%)

Query: 143  VDPSSNLYY-RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 201
            +DP +NL Y  WL  + +   +N +L+  R  F     + +  WL++DY  D++Y LD+ 
Sbjct: 648  IDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDIT 707

Query: 202  V-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRL 260
            V + R  F+  G +++D   +  +Y  + +FK+D+LSL+P D  YLKVG N P +R  R 
Sbjct: 708  VFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRC 766

Query: 261  LKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYP 320
            LK+   FEF  R E+  +   ++R+     Y+L  +H N+C+Y+  S + G G+  WVY 
Sbjct: 767  LKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYD 826

Query: 321  NISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGN 380
             +           YI   Y++  TL TIG  P P    E +F ++++  GV  F+ ++G 
Sbjct: 827  GVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQ 878

Query: 381  VGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLK 440
            +  ++    A +  +++ +DS  +YM F K+ K ++ RV  W++Y W ++  +DE E++ 
Sbjct: 879  MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMV 938

Query: 441  SLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKE 500
             LPDK++ ++AI+V+ + + KV +FQ C+  ++ +++ +LR  V+ P DY+CKKG+IG+E
Sbjct: 939  QLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGRE 998

Query: 501  MYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLF 559
            MYII  G++ V+   DG +  V L  GS FGEIS+L + G   GNRRTAN+ + G+++LF
Sbjct: 999  MYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLF 1055

Query: 560  CLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 597
             L K DL E L  YPE++K L +K R++L  +N   EE
Sbjct: 1056 ILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEE 1093


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  308 bits (788), Expect = 1e-83
 Identities = 181/542 (33%), Positives = 303/542 (55%), Gaps = 38/542 (7%)

Query: 146 SSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL-VRA 204
           +  LY  WL  + L   +N   +  R  F    ++ +  WL+ D   D++Y+ D+L ++ 
Sbjct: 214 TDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQP 273

Query: 205 RTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFS 264
           R  F+  G ++ D+N L +HY+T+T+F+LDV S++P D+ YL  G N P  R NR+LK++
Sbjct: 274 RLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYT 332

Query: 265 RLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISI 324
             FEF    E+  +   ++R+     Y+L I+H NAC+Y+  S + G GT  WVY     
Sbjct: 333 SFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEG- 391

Query: 325 PEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSM 384
                   +Y+   YW+  TL TIG  P P    E +F +++F  GV +F++++G +  +
Sbjct: 392 -------NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDV 444

Query: 385 ISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPD 444
           I    A++  F+A +D    YM    + K ++ RV  W++Y W +++ +DE ++LK+LP 
Sbjct: 445 IGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPT 504

Query: 445 KLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYII 504
            ++  +AI+V+   + KV +F+ C+  ++ +++L+L+  ++ PGD++CKKG+IGKEMYII
Sbjct: 505 TVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYII 564

Query: 505 NEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSK 563
             G++ V+   DG    V L  GS FGEIS+L   G   GNRRTAN+ + G+++L  L K
Sbjct: 565 KHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDK 621

Query: 564 DDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDL------EEKVEQLGS 617
             L E L  YP++++ L +K R +L +      + A A    KDL      +E+  +L  
Sbjct: 622 KTLQEILVHYPDSERILMKKARVLLKQ----KAKTAEATPPRKDLALLFPPKEETPKLFK 677

Query: 618 SL--DTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATK-TEDK 674
           +L   T +   ARLL        K+K+  +  + +   GG++   +G+   D  K  EDK
Sbjct: 678 TLLGGTGKASLARLL--------KLKREQAAQKKENSEGGEE---EGKENEDKQKENEDK 726

Query: 675 QQ 676
           Q+
Sbjct: 727 QK 728


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  191 bits (486), Expect = 1e-48
 Identities = 137/486 (28%), Positives = 241/486 (49%), Gaps = 42/486 (8%)

Query: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
           GSQ+  +R  +++ K     ++ P S+  + W   + L +  N  L+I        + E 
Sbjct: 235 GSQKAVER-EQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN--LIIIPVGITFFKDEN 291

Query: 182 LMLWLVLDYSADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLV 239
              W+V +  +D  +++D+++  RTG +  +   ++ D  R+   Y   + F +D +S +
Sbjct: 292 TTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKY-LKSWFMVDFISSI 350

Query: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
           P D  +L V T               VRF       RLL+ SRL  +  + E     T  
Sbjct: 351 PVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 410

Query: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
               + RI NL+  +L++ HW+ C+ F +     F  D WV  N  +  +    ++Y Y+
Sbjct: 411 LASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMV--NNSWGKQYSYA 468

Query: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
           L+ +   +  IG     PV   +    ++  +VG   +A  +G+  ++I ++++SR ++Q
Sbjct: 469 LFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQ 528

Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
            K   ++QYM F K+  D   R+  ++++ +   K  DE+ +L  L + L+ EI IN + 
Sbjct: 529 EKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQG-KMFDEESILGELSEPLREEI-INFNC 586

Query: 457 DTL-KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADD 515
             L   + +F + +   +  ++ KLR  VF PGDYI ++G IGK+MY I  G ++V+   
Sbjct: 587 RKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG 646

Query: 516 GVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
              +   L+DGSYFGEI +L      +  RRTA++R+  Y  L+ LS D+  E L EYP 
Sbjct: 647 --NKETKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPM 698

Query: 576 AKKALE 581
            ++A E
Sbjct: 699 MRRAFE 704


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  186 bits (471), Expect = 8e-47
 Identities = 131/485 (27%), Positives = 241/485 (49%), Gaps = 40/485 (8%)

Query: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
           GSQ+  ++  +++ K     ++ P S+  + W   + + +  N  ++     F   Q+  
Sbjct: 115 GSQKAVEK-EQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTT- 172

Query: 182 LMLWLVLDYSADVLYVLDVLVRARTGFLEQGL--MVSDTNRLWQHYKTTTQFKLDVLSLV 239
              W++ + ++D +++LD+++  RTG + +    ++ D   +  +Y   + F +D +S +
Sbjct: 173 -TPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNY-LKSWFVVDFISSI 230

Query: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
           P D  +L V                 VRF       RLL+ SRL  +  + E     T  
Sbjct: 231 PVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 290

Query: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
               + RI NL+  +L++ HW+ C+ F +     F  D WV  N  + +     ++Y Y+
Sbjct: 291 LASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW--GKQYSYA 348

Query: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
           L+ +   +  IG     PV   +    ++  +VG   +A  VG+  ++I ++++SR ++Q
Sbjct: 349 LFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQ 408

Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
            K   ++QYM F K+  D+  ++  ++++ +   K  DE+ +L  L D L+ EI      
Sbjct: 409 EKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQG-KIFDEENILNELNDPLREEIVNFNCR 467

Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
             +  + +F + +   +  ++ KLR  VF PGDYI ++G +GK+MY I  G   V+    
Sbjct: 468 KLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS- 526

Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
            ++ + L+DGSYFGEI +L  KG     RRTA++R+  Y  L+ LS D+  E L EYP  
Sbjct: 527 -SKEMKLTDGSYFGEICLLT-KG-----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMM 579

Query: 577 KKALE 581
           ++A E
Sbjct: 580 RRAFE 584


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  181 bits (460), Expect = 2e-45
 Identities = 131/485 (27%), Positives = 236/485 (48%), Gaps = 40/485 (8%)

Query: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
           GSQ+  +R  +++ K   A ++ P S+  + W   + L +  N  L+I        + E 
Sbjct: 184 GSQKAVER-EQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGN--LIIIPVGITFFKDET 240

Query: 182 LMLWLVLDYSADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLV 239
              W+V +  +D  +++D+++  RTG +  +   ++ D  ++ + Y   T F +D +S +
Sbjct: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSI 299

Query: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
           P D  +L V                 VRF       RLL+ SRL  +  + E     T  
Sbjct: 300 PVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 359

Query: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
               + RI NL+  +L++ HW+ C+ F +     F  + WV  N  +  +   S  Y ++
Sbjct: 360 LASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMV--NHSWSELYSFA 417

Query: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
           L+ +   +  IG     P    +    ++  +VG   +A  +G+  ++I ++++SR ++Q
Sbjct: 418 LFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQ 477

Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
            K   ++QYM F K+  D   ++  ++++ +   K  DE  +L  L   L+ EI      
Sbjct: 478 EKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG-KMFDEDSILGELNGPLREEIVNFNCR 536

Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
             +  + +F + +   +  ++ KL+  VF PGDYI ++G IGK+MY I  G ++V+    
Sbjct: 537 KLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG- 595

Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
             + + LSDGSYFGEI +L      +  RRTA++R+  Y  L+ LS D+  E L EYP  
Sbjct: 596 -NKEMKLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMM 648

Query: 577 KKALE 581
           ++A E
Sbjct: 649 RRAFE 653


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  181 bits (458), Expect = 3e-45
 Identities = 132/500 (26%), Positives = 238/500 (47%), Gaps = 39/500 (7%)

Query: 132 RKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
           +++ K   A ++ P S+  + W   + L +  N  +L     F   + E    W+V +  
Sbjct: 75  QERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNVL 132

Query: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 246
           +D  ++LD+++  RTG + E+G  +    R  +     T F +D++S +P D  +L    
Sbjct: 133 SDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVEL 192

Query: 247 ---------KVGTNYPEVRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 286
                    K       VRF       RLL+ SRL  +  + E     T      + RI 
Sbjct: 193 EPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 252

Query: 287 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 346
           NL+  +L++ HW+ C+ F +     F  D WV  N  +  +    R+Y ++L+ +   + 
Sbjct: 253 NLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMV--NHSWGRQYSHALFKAMSHML 310

Query: 347 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405
            IG     PV   +    ++  +VG   +A  +G+  ++I ++++SR ++Q K   ++QY
Sbjct: 311 CIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 370

Query: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465
           M F K+  D   R+  ++++ +   K  DE+ +L  L + L+ EI        +  + +F
Sbjct: 371 MSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEIINFTCRGLVAHMPLF 429

Query: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525
              +   +  ++ KLR  VF PGD + ++G +G++MY I  G L+V+A     +   L+D
Sbjct: 430 AHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTD 487

Query: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGR 585
           GSYFGEI +L      +  RRTA++R+  Y  L+ LS D     L E+P  ++A E    
Sbjct: 488 GSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAM 541

Query: 586 QILMKDNLIDEELARAGADP 605
             L++    +  L R  ++P
Sbjct: 542 DRLLRIGKKNSILQRKRSEP 561


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  163 bits (413), Expect = 4e-40
 Identities = 112/409 (27%), Positives = 203/409 (49%), Gaps = 31/409 (7%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++++D+L+  RT ++ Q   +VSD  ++  HY     F +D+++ +P DL  
Sbjct: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 511

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
              G++        LLK +RL            Y      G  VL +L     +I HW A
Sbjct: 512 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 567

Query: 301 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 347
           CI++AI      + TD   W+          Y +        +  KY+ +LY++  +LT+
Sbjct: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627

Query: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687

Query: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 466
           +F ++   L  R+  +F + W     +D   VLK  P+ L+A+I ++++   L+  + F+
Sbjct: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747

Query: 467 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 526
               G L  L +K + T   PGD +   GD+   +Y ++ G + ++ DD V    +L   
Sbjct: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805

Query: 527 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
             FGE+  L  K  KS     A++R++ Y DL  + ++DL+E L  YPE
Sbjct: 806 DIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  162 bits (410), Expect = 9e-40
 Identities = 114/408 (27%), Positives = 202/408 (49%), Gaps = 31/408 (7%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++V+D+++  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
            + G++        LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416

Query: 301 CIYFAISKF--------IGF----GTDSWVYPNISIPEHG-RLSRKYIYSLYWSTLTLTT 347
           CI++AI           IG+    G       N S P  G  +  KY+ +LY++  +LT+
Sbjct: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476

Query: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536

Query: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 466
           +F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I +++H   L+    F 
Sbjct: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596

Query: 467 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 526
               G L  L +K + T   PGD +   GD+   +Y I+ G + ++ DD V    +L   
Sbjct: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKN 654

Query: 527 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 574
             FGE   L+ +  KS    +A++R++ Y DL  + + DL+E L  YP
Sbjct: 655 DIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  157 bits (398), Expect = 2e-38
 Identities = 110/408 (26%), Positives = 200/408 (49%), Gaps = 33/408 (8%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
              G+         LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 173 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 225

Query: 301 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 348
           CI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT++
Sbjct: 226 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 285

Query: 349 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 407
           G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++++
Sbjct: 286 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 345

Query: 408 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 467
           F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F+ 
Sbjct: 346 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 405

Query: 468 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 527
              G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L    
Sbjct: 406 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKND 463

Query: 528 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
            FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 464 IFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  157 bits (398), Expect = 2e-38
 Identities = 110/408 (26%), Positives = 200/408 (49%), Gaps = 33/408 (8%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
              G+         LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 513 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 565

Query: 301 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 348
           CI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT++
Sbjct: 566 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 625

Query: 349 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 407
           G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++++
Sbjct: 626 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 685

Query: 408 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 467
           F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F+ 
Sbjct: 686 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 745

Query: 468 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 527
              G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L    
Sbjct: 746 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKND 803

Query: 528 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
            FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 804 IFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  155 bits (393), Expect = 9e-38
 Identities = 132/515 (25%), Positives = 239/515 (46%), Gaps = 61/515 (11%)

Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256

Query: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 246
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315

Query: 247 --KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWN 299
              + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW 
Sbjct: 316 DEGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGLAAHWM 366

Query: 300 ACIYFAISKFIGFGTD-------SWVYP---NISIPE--HGRLSRK----------YIYS 337
           ACI+++I  +  F  D       SW+Y    +I  P   +G  S K          YI S
Sbjct: 367 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 426

Query: 338 LYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
           LY++  +LT++G     P  D E +F V   ++G L++ATI GNV ++   M A+   + 
Sbjct: 427 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 486

Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
             ++S++ +++  +V K L  RV+ +    W+  + +D ++VL+  P  ++A+I ++++ 
Sbjct: 487 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 546

Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
              K+   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 547 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 606

Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
           V    +L  G  FG++       ++S     AN+R++ Y DL  + +D L + L  Y   
Sbjct: 607 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFYTAF 660

Query: 577 KKALEEKGRQILMKDNLIDEELARAGADPKDLEEK 611
             +     R +++  NL    + R  +D K  EE+
Sbjct: 661 SHSF---SRNLILTYNLRKRIVFRKISDVKREEEE 692


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  153 bits (387), Expect = 4e-37
 Identities = 114/485 (23%), Positives = 228/485 (47%), Gaps = 33/485 (6%)

Query: 120 NVGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACF---DE 176
           NV   +PA    +    KK   ++   S     W   I L  FY    +    CF   D+
Sbjct: 191 NVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDD 250

Query: 177 LQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDV 235
           L +       V D + ++L+++D+++  RT ++ + G ++ +   +  HY  TT F +D+
Sbjct: 251 LSTTRSTT--VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY-VTTWFIIDL 307

Query: 236 LSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILII 295
           ++ +P DL Y    T    V   + ++  RL     + +  + +  +  +  L+    ++
Sbjct: 308 IAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV-LTLLMSMFALL 366

Query: 296 IHWNACIYFAISKFIGFGTD------SWVYP---NISIPEHGR-------LSRKYIYSLY 339
            HW ACI++ I K              W++     +  P +G        +   YI +LY
Sbjct: 367 AHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALY 426

Query: 340 WSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
           ++  +LT++G        D E +F +   L+G L+ A + GNV ++I  M +  + +  +
Sbjct: 427 FTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTR 486

Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
              +K +++   + + L+ R++ +F   W+    +D  E+LK  PD+L+++I ++++ + 
Sbjct: 487 TKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEI 546

Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
           L ++ +F+    G L  L L ++ +  +PG+Y+ ++GD  + +Y +  G + V+ D  V 
Sbjct: 547 L-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV- 604

Query: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE-AK 577
              +L  G   G     N+       +  A+++++ Y DL C+    L E L  YPE A 
Sbjct: 605 -LAILGKGDLIG----ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAH 659

Query: 578 KALEE 582
           K +E+
Sbjct: 660 KFVED 664


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  153 bits (386), Expect = 6e-37
 Identities = 127/499 (25%), Positives = 238/499 (47%), Gaps = 39/499 (7%)

Query: 153 WLTAIALPVFYNWYLLICRACF--DELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLE 210
           W   I L  FY    +    CF  D+         LV D + ++L++LD+++  RT ++ 
Sbjct: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288

Query: 211 Q-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEF 269
           Q G ++S    +  HY   T F +D+++ +P DL Y+   T    V   + ++  RL   
Sbjct: 289 QSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRL 347

Query: 270 FDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTD------SWV----- 318
             + E R +  +   +  L+    ++ HW ACI++ I +      D       W+     
Sbjct: 348 LQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGK 406

Query: 319 -----YPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVL 372
                Y N S+    R S  YI +LY++  +LT++G        D E +F +   L+G L
Sbjct: 407 RLEVPYVNGSVGGPSRRSA-YIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465

Query: 373 IFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKT 432
           + A + GNV ++I  M + R+ + +++  +K +++  ++ + L+ R++ +F   WA    
Sbjct: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525

Query: 433 VDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYIC 492
           +D  E+L+  PD+L+A+IA++++ + L ++ +F     G L  L L ++ +  +PG+Y+ 
Sbjct: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584

Query: 493 KKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSG--------N 544
           ++GD  +  Y +  G L V+ D+ V    +L  G   G  + +   G + G         
Sbjct: 585 RRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVL 640

Query: 545 RRTANIRSIGYSDLFCLSKDDLMEALTEYPE---AKKALEEKGRQILMKDNLIDEELARA 601
           + +A+++++ Y  L  LS   L E L  YPE   A +A   +     ++       L+R 
Sbjct: 641 KTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF 700

Query: 602 GADPKDLEEKVEQLGSSLD 620
              P+  + + E LGSS D
Sbjct: 701 SRSPRLSQPRSESLGSSSD 719


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  152 bits (385), Expect = 7e-37
 Identities = 114/434 (26%), Positives = 201/434 (46%), Gaps = 54/434 (12%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V D + +VL++LD+++  RT F+ + G +V     +  HY  TT F LDV++ +P DL +
Sbjct: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHY-VTTWFLLDVIAALPFDLLH 321

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFA 305
                 Y      + ++  RL     R +  + Y  +  +  L+    ++ HW AC++F 
Sbjct: 322 AFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380

Query: 306 ISKF-----------IGF---------------------GTDSWVYPNISIPEHGR---- 329
           I +            IG+                     G  S    N S          
Sbjct: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440

Query: 330 -------LSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNV 381
                  L   YI SLY++  +LT++G        D E +F +   L+G L+ A + GNV
Sbjct: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500

Query: 382 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 441
            ++I  M A R  + ++   ++ Y++  ++ K L+ R++ +F   WA    +D  E+L+S
Sbjct: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560

Query: 442 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 501
           LPD+L+A+IA+++H + L ++ +F+    G L  L L LRP   +PG+Y+  +GD  + +
Sbjct: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619

Query: 502 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
           Y +  G + V+   G T   +L  G   G      +   +   +  A+++ + Y  L CL
Sbjct: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673

Query: 562 SKDDLMEALTEYPE 575
               L ++L  YPE
Sbjct: 674 QLAGLHDSLALYPE 687


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  150 bits (379), Expect = 4e-36
 Identities = 128/513 (24%), Positives = 228/513 (44%), Gaps = 58/513 (11%)

Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253

Query: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313

Query: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364

Query: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424

Query: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484

Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544

Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 604

Query: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 578
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y     
Sbjct: 605 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658

Query: 579 ALEEKGRQILMKDNLIDEELARAGADPKDLEEK 611
           +     R + +  NL    + R  +D K  EE+
Sbjct: 659 SF---SRNLTLTCNLRKRIIFRKISDVKKEEEE 688


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  148 bits (373), Expect = 2e-35
 Identities = 120/475 (25%), Positives = 214/475 (45%), Gaps = 55/475 (11%)

Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 138 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 195

Query: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 196 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 255

Query: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 256 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 306

Query: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 307 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 366

Query: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 367 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 426

Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 427 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 486

Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 487 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 546

Query: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 573
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y
Sbjct: 547 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFY 595


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  147 bits (370), Expect = 4e-35
 Identities = 135/542 (24%), Positives = 244/542 (45%), Gaps = 88/542 (16%)

Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256

Query: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL------- 243
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315

Query: 244 ----AYL----KVG------------------TNYPEVRFNRLLKFSRLFEFFDRTETRT 277
               A++    K+G                  + +  ++  RLL+  R+    D      
Sbjct: 316 DEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD------ 369

Query: 278 NYPNMFRIGNLVLYILIII-----HWNACIYFAISKFIGFGTD-------SWVYP---NI 322
              +    G  VL +L+ +     HW ACI+++I  +  F  D       SW+Y    +I
Sbjct: 370 ---HYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDI 426

Query: 323 SIPE--HGRLSRK----------YIYSLYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLV 369
             P   +G  S K          YI SLY++  +LT++G     P  D E +F V   ++
Sbjct: 427 GTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMI 486

Query: 370 GVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWAN 429
           G L++ATI GNV ++   M A+   +   ++S++ +++  +V K L  RV+ +    W+ 
Sbjct: 487 GSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSM 546

Query: 430 KKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGD 489
            + +D ++VL+  P  ++A+I ++++    K+   F+    G L  L ++ +    +PGD
Sbjct: 547 SRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGD 606

Query: 490 YICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTAN 549
            I   G+    +  +  G L V+ DD V    +L  G  FG++       ++S     AN
Sbjct: 607 LIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS----CAN 660

Query: 550 IRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLE 609
           +R++ Y DL  + +D L + L  Y     +     R +++  NL    + R  +D K  E
Sbjct: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISDVKREE 717

Query: 610 EK 611
           E+
Sbjct: 718 EE 719


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  143 bits (360), Expect = 6e-34
 Identities = 104/394 (26%), Positives = 183/394 (46%), Gaps = 56/394 (14%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++V+D+++  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
            + G++        LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416

Query: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360
           CI    S  +GFG       N+S                              P  + E 
Sbjct: 417 CICSLTS--VGFG-------NVS------------------------------PNTNSEK 437

Query: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420
           +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K++++F ++   L  R+ 
Sbjct: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497

Query: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480
            +F + W+    +D   VLK  P+ L+A+I +++H   L+    F     G L  L +K 
Sbjct: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557

Query: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540
           + T   PGD +   GD+   +Y I+ G + ++ DD V    +L     FGE   L+ +  
Sbjct: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615

Query: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 574
           KS    +A++R++ Y DL  + + DL+E L  YP
Sbjct: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  138 bits (347), Expect = 2e-32
 Identities = 100/394 (25%), Positives = 189/394 (47%), Gaps = 31/394 (7%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
              G+         LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 513 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 565

Query: 301 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 348
           CI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT++
Sbjct: 566 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 625

Query: 349 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 407
           G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++++
Sbjct: 626 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 685

Query: 408 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 467
           F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F+ 
Sbjct: 686 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 745

Query: 468 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 527
              G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V   + +  G+
Sbjct: 746 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGA 805

Query: 528 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
             G    L +  + S      N++S+G     CL
Sbjct: 806 GTG----LEMPSAASRGASLLNMQSLGLWTWDCL 835


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  133 bits (334), Expect = 6e-31
 Identities = 106/419 (25%), Positives = 189/419 (45%), Gaps = 49/419 (11%)

Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253

Query: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313

Query: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364

Query: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424

Query: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484

Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544

Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGV 517
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V
Sbjct: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEV 603


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 70/276 (25%), Positives = 132/276 (47%), Gaps = 25/276 (9%)

Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
           V+D   D+++++D+L+  RT ++ Q   +VSD  ++  HY     F +D+++ +P DL  
Sbjct: 446 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 504

Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
              G++        LLK +RL            Y      G  VL +L     +I HW A
Sbjct: 505 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 560

Query: 301 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 347
           CI++AI      + TD   W+          Y +        +  KY+ +LY++  +LT+
Sbjct: 561 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 620

Query: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 621 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 680

Query: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSL 442
           +F ++   L  R+  +F + W     +D   V  S+
Sbjct: 681 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVCMSV 716


>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
           sapiens]
          Length = 671

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 10/100 (10%)

Query: 455 HLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD 514
           +++ LK V  FQ     +L +L   L  T +  G+YI ++G  G   +II++G + V  +
Sbjct: 212 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 271

Query: 515 DGVTQFVV----LSDGSYFGEISILNIKGSKSGNRRTANI 550
           D  ++  V    L  G +FGE      K  +  + RTAN+
Sbjct: 272 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 305



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525
           ++ E   + E+V  + P  +     I K+GD+G  +Y++ +GK+ V  +    +   +  
Sbjct: 105 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 162

Query: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEAL--------TEYPEAK 577
           G  FGE++IL          RTA ++++    L+ + +      +        TEY E  
Sbjct: 163 GKVFGELAIL------YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFL 216

Query: 578 KAL 580
           K++
Sbjct: 217 KSV 219


>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
           sapiens]
          Length = 686

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 10/100 (10%)

Query: 455 HLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD 514
           +++ LK V  FQ     +L +L   L  T +  G+YI ++G  G   +II++G + V  +
Sbjct: 227 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 286

Query: 515 DGVTQFVV----LSDGSYFGEISILNIKGSKSGNRRTANI 550
           D  ++  V    L  G +FGE      K  +  + RTAN+
Sbjct: 287 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 320



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525
           ++ E   + E+V  + P  +     I K+GD+G  +Y++ +GK+ V  +    +   +  
Sbjct: 120 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 177

Query: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEAL--------TEYPEAK 577
           G  FGE++IL          RTA ++++    L+ + +      +        TEY E  
Sbjct: 178 GKVFGELAIL------YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFL 231

Query: 578 KAL 580
           K++
Sbjct: 232 KSV 234


>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
          Length = 762

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 13/129 (10%)

Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVV----AD 514
           L+ V + ++     L +++  L    +  GDYI ++G+ G   +I+ +GK+ V       
Sbjct: 281 LRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

Query: 515 DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL--SKDDLMEALTE 572
           D       L  G YFGE +++      S + R+ANI +   +D+ CL   ++   + +  
Sbjct: 341 DQPQLIKTLQKGEYFGEKALI------SDDVRSANIIA-EENDVACLVIDRETFNQTVGT 393

Query: 573 YPEAKKALE 581
           + E +K LE
Sbjct: 394 FEELQKYLE 402



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 11/138 (7%)

Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
           D L K +  +  +   + ++V  +    +  G YI K+G+ G  ++++ EG+L V   + 
Sbjct: 161 DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEK 220

Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
           +   + +   + FGE++IL          RTA++++I     + L ++     +    +A
Sbjct: 221 LLSSIPM--WTTFGELAIL------YNCTRTASVKAITNVKTWALDREVFQNIMRRTAQA 272

Query: 577 KKALEEKGRQILMKDNLI 594
           +   +E+ R  L   +L+
Sbjct: 273 R---DEQYRNFLRSVSLL 287


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,898,795
Number of Sequences: 37866
Number of extensions: 1018367
Number of successful extensions: 4079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 3704
Number of HSP's gapped (non-prelim): 344
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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