Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 120433600
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
(676 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 1345 0.0
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 1332 0.0
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 847 0.0
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 847 0.0
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 832 0.0
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 598 e-171
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 315 7e-86
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 308 1e-83
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 191 1e-48
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 186 8e-47
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 181 2e-45
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 181 3e-45
gi|27886653 potassium voltage-gated channel, subfamily H, member... 163 4e-40
gi|13540549 potassium voltage-gated channel, subfamily H, member... 162 9e-40
gi|26051273 voltage-gated potassium channel, subfamily H, member... 157 2e-38
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 157 2e-38
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 155 9e-38
gi|27886667 potassium voltage-gated channel, subfamily H, member... 153 4e-37
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 153 6e-37
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 152 7e-37
gi|22024390 potassium voltage-gated channel, subfamily H, member... 150 4e-36
gi|27886648 potassium voltage-gated channel, subfamily H, member... 148 2e-35
gi|27437001 potassium voltage-gated channel, subfamily H, member... 147 4e-35
gi|27886651 potassium voltage-gated channel, subfamily H, member... 143 6e-34
gi|26051271 voltage-gated potassium channel, subfamily H, member... 138 2e-32
gi|27886646 potassium voltage-gated channel, subfamily H, member... 133 6e-31
gi|27886665 potassium voltage-gated channel, subfamily H, member... 93 7e-19
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 44 5e-04
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 44 5e-04
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 42 0.001
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 1345 bits (3481), Expect = 0.0
Identities = 676/676 (100%), Positives = 676/676 (100%)
Query: 1 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS
Sbjct: 1 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
Query: 61 GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN
Sbjct: 61 GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
Query: 121 VGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSE 180
VGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSE
Sbjct: 121 VGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSE 180
Query: 181 YLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVP 240
YLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVP
Sbjct: 181 YLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVP 240
Query: 241 TDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNA 300
TDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNA
Sbjct: 241 TDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNA 300
Query: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360
CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY
Sbjct: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360
Query: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420
LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI
Sbjct: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420
Query: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480
RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL
Sbjct: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480
Query: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540
RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS
Sbjct: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540
Query: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAR 600
KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAR
Sbjct: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAR 600
Query: 601 AGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLA 660
AGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLA
Sbjct: 601 AGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLA 660
Query: 661 DGEVPGDATKTEDKQQ 676
DGEVPGDATKTEDKQQ
Sbjct: 661 DGEVPGDATKTEDKQQ 676
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 1332 bits (3447), Expect = 0.0
Identities = 675/694 (97%), Positives = 675/694 (97%), Gaps = 18/694 (2%)
Query: 1 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS
Sbjct: 1 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
Query: 61 GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN
Sbjct: 61 GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
Query: 121 VGSQEPADRGR------------------RKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 162
VGSQEPADRGR KKTKKKDAIVVDPSSNLYYRWLTAIALPVF
Sbjct: 121 VGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 180
Query: 163 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 222
YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW
Sbjct: 181 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 240
Query: 223 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 282
QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM
Sbjct: 241 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 300
Query: 283 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 342
FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST
Sbjct: 301 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 360
Query: 343 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 402
LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI
Sbjct: 361 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 420
Query: 403 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 462
KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV
Sbjct: 421 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 480
Query: 463 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 522
RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV
Sbjct: 481 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 540
Query: 523 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 582
LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE
Sbjct: 541 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 600
Query: 583 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 642
KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ
Sbjct: 601 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 660
Query: 643 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 676
RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
Sbjct: 661 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 694
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 847 bits (2189), Expect = 0.0
Identities = 424/677 (62%), Positives = 524/677 (77%), Gaps = 19/677 (2%)
Query: 4 INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63
INTQ S + ++ V ++++ R ENG + S ++++S + E+ +G
Sbjct: 79 INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 133
Query: 64 SFTGQGIAR---LSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
SF+ + + + R +L A +V++ ++ + + K+ S + N N
Sbjct: 134 SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKN 193
Query: 121 VGSQEPADRGRRKKTK-----------KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 169
++ + + KK K KK+ +V+DPS N YY WL I LPV YNW ++I
Sbjct: 194 DPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 253
Query: 170 CRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTT 229
RACFDELQS+YL WL+LDY +D++Y++D+ VR RTG+LEQGL+V + +L YK+
Sbjct: 254 ARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNL 313
Query: 230 QFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLV 289
QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNYPN+FRI NLV
Sbjct: 314 QFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLV 373
Query: 290 LYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIG 349
+YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLYWSTLTLTTIG
Sbjct: 374 MYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIG 433
Query: 350 ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFR 409
ETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+ID+IKQYM FR
Sbjct: 434 ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFR 493
Query: 410 KVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCE 469
V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTLKKVRIF DCE
Sbjct: 494 NVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCE 553
Query: 470 AGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYF 529
AGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQFVVLSDGSYF
Sbjct: 554 AGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYF 613
Query: 530 GEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILM 589
GEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK LEEKG+QILM
Sbjct: 614 GEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 673
Query: 590 KDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLES 649
KD L+D +A AG+DPKDLEEKV ++ S+D LQTRFAR+LAEY + Q K+KQRL+++E
Sbjct: 674 KDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEK 733
Query: 650 QVKGGGDKPLADGEVPG 666
+K D + E PG
Sbjct: 734 FLKPLIDTEFSSIEGPG 750
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 847 bits (2189), Expect = 0.0
Identities = 424/677 (62%), Positives = 524/677 (77%), Gaps = 19/677 (2%)
Query: 4 INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63
INTQ S + ++ V ++++ R ENG + S ++++S + E+ +G
Sbjct: 10 INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 64
Query: 64 SFTGQGIAR---LSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
SF+ + + + R +L A +V++ ++ + + K+ S + N N
Sbjct: 65 SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKN 124
Query: 121 VGSQEPADRGRRKKTK-----------KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 169
++ + + KK K KK+ +V+DPS N YY WL I LPV YNW ++I
Sbjct: 125 DPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 184
Query: 170 CRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTT 229
RACFDELQS+YL WL+LDY +D++Y++D+ VR RTG+LEQGL+V + +L YK+
Sbjct: 185 ARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNL 244
Query: 230 QFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLV 289
QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNYPN+FRI NLV
Sbjct: 245 QFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLV 304
Query: 290 LYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIG 349
+YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLYWSTLTLTTIG
Sbjct: 305 MYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIG 364
Query: 350 ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFR 409
ETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+ID+IKQYM FR
Sbjct: 365 ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFR 424
Query: 410 KVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCE 469
V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTLKKVRIF DCE
Sbjct: 425 NVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCE 484
Query: 470 AGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYF 529
AGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQFVVLSDGSYF
Sbjct: 485 AGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYF 544
Query: 530 GEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILM 589
GEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK LEEKG+QILM
Sbjct: 545 GEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 604
Query: 590 KDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLES 649
KD L+D +A AG+DPKDLEEKV ++ S+D LQTRFAR+LAEY + Q K+KQRL+++E
Sbjct: 605 KDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEK 664
Query: 650 QVKGGGDKPLADGEVPG 666
+K D + E PG
Sbjct: 665 FLKPLIDTEFSSIEGPG 681
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 832 bits (2150), Expect = 0.0
Identities = 421/666 (63%), Positives = 517/666 (77%), Gaps = 23/666 (3%)
Query: 3 KINTQYSHPSRTHLK-----VKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGL 57
K N S P+ H +K + +D +R SR HS++++ +S E + L
Sbjct: 4 KTNGVKSSPANNHNHHAPPAIKANGKDDHRTS---SRPHSAADDDTS-------SELQRL 53
Query: 58 ADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
AD G R+ RL+ ++R WA ++ ++ PDSF +RFRG EL+ V++QE +
Sbjct: 54 ADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDG 113
Query: 118 QANVGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDEL 177
+ G ++ D+G +KK + V+DP+ + YY WL IA+PV YNW LL+ RACF +L
Sbjct: 114 K---GDKDGEDKGTKKKF---ELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDL 167
Query: 178 QSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLS 237
Q Y ++WLVLDY +DV+Y+ D+ +R RTGFLEQGL+V DT +L +Y T QFKLDV S
Sbjct: 168 QKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVAS 227
Query: 238 LVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIH 297
++PTDL Y V + PEVRFNRLL F+R+FEFFDRTETRTNYPN+FRI NLVLYIL+IIH
Sbjct: 228 IIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIH 287
Query: 298 WNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKD 357
WNACIY+AISK IGFG D+WVYPNI+ PE+G L+R+YIY LYWSTLTLTTIGETPPPVKD
Sbjct: 288 WNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKD 347
Query: 358 EEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLET 417
EEYLFV+ DFL+GVLIFATIVGNVGSMISNMNA+RAEFQAKID++K YMQFRKV+K +E
Sbjct: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407
Query: 418 RVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELV 477
+VIRWFDYLW NKKTVDE+E+LK+LP KL+AEIAINVHL TLKKVRIF DCEAGLLVELV
Sbjct: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467
Query: 478 LKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNI 537
LKLRP VFSPGDYIC+KGDIGKEMYII EGKLAVVADDGVTQ+ +LS GS FGEISILNI
Sbjct: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527
Query: 538 KGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 597
KGSK GNRRTANIRS+GYSDLFCLSKDDLMEA+TEYP+AKK LEE+GR+ILMK+ L+DE
Sbjct: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDEN 587
Query: 598 LARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVK-GGGD 656
+ D++EK+ QL ++++TL TRF RLLAEY Q K+KQR++ LE+++K D
Sbjct: 588 EVATSME-VDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNED 646
Query: 657 KPLADG 662
L+DG
Sbjct: 647 DYLSDG 652
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 598 bits (1542), Expect = e-171
Identities = 288/534 (53%), Positives = 396/534 (74%), Gaps = 9/534 (1%)
Query: 142 VVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 201
V+DPS + YY WL + PV YN +L+CRACF +LQ YL+ WLVLDY++D+LY+LD++
Sbjct: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
Query: 202 VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLL 261
VR TGFLEQG++V D R+ Y T F LD+ SL+PTD+ Y+++G + P +R NR L
Sbjct: 86 VRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFL 145
Query: 262 KFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPN 321
+ RLFE FDRTETRT YPN FRI L+LYI ++IHWN+C+YFA+S+++GFG D+WVYP+
Sbjct: 146 RAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPD 205
Query: 322 ISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNV 381
+ P RL R+Y+YS Y+STL LTT+G+TPPP ++EEYLF+V DFL+ V+ FATI+G++
Sbjct: 206 PAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSM 265
Query: 382 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 441
S+I NMN + A F +K+YM+ + V + LE RVI W+ +L NKK +E +L+
Sbjct: 266 SSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQH 325
Query: 442 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 501
LP++L+AE+A++VHL TL +V+IFQ+CEA LL ELVLKL+P +SPG+Y+C+KGDIG+EM
Sbjct: 326 LPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEM 385
Query: 502 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
YII EG+LAVVADDG+TQ+ VL G YFGEISI+NIKG+ SGNRRTANI+S+GYSDLFCL
Sbjct: 386 YIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCL 445
Query: 562 SKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAG-ADPKDLEEKVEQLGSSLD 620
SK+DL E L+EYP+A+ +EEKGR+IL+K N +D A A + E ++ L LD
Sbjct: 446 SKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLD 505
Query: 621 TLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDK 674
LQT+FARLLAE ++ +K+ R+ +LE Q + + +P D + +D+
Sbjct: 506 DLQTKFARLLAELESSALKIAYRIERLEWQTR--------EWPMPEDLAEADDE 551
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 315 bits (808), Expect = 7e-86
Identities = 165/458 (36%), Positives = 272/458 (59%), Gaps = 15/458 (3%)
Query: 143 VDPSSNLYY-RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 201
+DP +NL Y WL + + +N +L+ R F + + WL++DY D++Y LD+
Sbjct: 648 IDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDIT 707
Query: 202 V-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRL 260
V + R F+ G +++D + +Y + +FK+D+LSL+P D YLKVG N P +R R
Sbjct: 708 VFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRC 766
Query: 261 LKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYP 320
LK+ FEF R E+ + ++R+ Y+L +H N+C+Y+ S + G G+ WVY
Sbjct: 767 LKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYD 826
Query: 321 NISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGN 380
+ YI Y++ TL TIG P P E +F ++++ GV F+ ++G
Sbjct: 827 GVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQ 878
Query: 381 VGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLK 440
+ ++ A + +++ +DS +YM F K+ K ++ RV W++Y W ++ +DE E++
Sbjct: 879 MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMV 938
Query: 441 SLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKE 500
LPDK++ ++AI+V+ + + KV +FQ C+ ++ +++ +LR V+ P DY+CKKG+IG+E
Sbjct: 939 QLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGRE 998
Query: 501 MYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLF 559
MYII G++ V+ DG + V L GS FGEIS+L + G GNRRTAN+ + G+++LF
Sbjct: 999 MYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLF 1055
Query: 560 CLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 597
L K DL E L YPE++K L +K R++L +N EE
Sbjct: 1056 ILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEE 1093
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 308 bits (788), Expect = 1e-83
Identities = 181/542 (33%), Positives = 303/542 (55%), Gaps = 38/542 (7%)
Query: 146 SSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL-VRA 204
+ LY WL + L +N + R F ++ + WL+ D D++Y+ D+L ++
Sbjct: 214 TDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQP 273
Query: 205 RTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFS 264
R F+ G ++ D+N L +HY+T+T+F+LDV S++P D+ YL G N P R NR+LK++
Sbjct: 274 RLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYT 332
Query: 265 RLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISI 324
FEF E+ + ++R+ Y+L I+H NAC+Y+ S + G GT WVY
Sbjct: 333 SFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEG- 391
Query: 325 PEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSM 384
+Y+ YW+ TL TIG P P E +F +++F GV +F++++G + +
Sbjct: 392 -------NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDV 444
Query: 385 ISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPD 444
I A++ F+A +D YM + K ++ RV W++Y W +++ +DE ++LK+LP
Sbjct: 445 IGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPT 504
Query: 445 KLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYII 504
++ +AI+V+ + KV +F+ C+ ++ +++L+L+ ++ PGD++CKKG+IGKEMYII
Sbjct: 505 TVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYII 564
Query: 505 NEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSK 563
G++ V+ DG V L GS FGEIS+L G GNRRTAN+ + G+++L L K
Sbjct: 565 KHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDK 621
Query: 564 DDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDL------EEKVEQLGS 617
L E L YP++++ L +K R +L + + A A KDL +E+ +L
Sbjct: 622 KTLQEILVHYPDSERILMKKARVLLKQ----KAKTAEATPPRKDLALLFPPKEETPKLFK 677
Query: 618 SL--DTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATK-TEDK 674
+L T + ARLL K+K+ + + + GG++ +G+ D K EDK
Sbjct: 678 TLLGGTGKASLARLL--------KLKREQAAQKKENSEGGEE---EGKENEDKQKENEDK 726
Query: 675 QQ 676
Q+
Sbjct: 727 QK 728
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 191 bits (486), Expect = 1e-48
Identities = 137/486 (28%), Positives = 241/486 (49%), Gaps = 42/486 (8%)
Query: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
GSQ+ +R +++ K ++ P S+ + W + L + N L+I + E
Sbjct: 235 GSQKAVER-EQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN--LIIIPVGITFFKDEN 291
Query: 182 LMLWLVLDYSADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLV 239
W+V + +D +++D+++ RTG + + ++ D R+ Y + F +D +S +
Sbjct: 292 TTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKY-LKSWFMVDFISSI 350
Query: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
P D +L V T VRF RLL+ SRL + + E T
Sbjct: 351 PVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 410
Query: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
+ RI NL+ +L++ HW+ C+ F + F D WV N + + ++Y Y+
Sbjct: 411 LASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMV--NNSWGKQYSYA 468
Query: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
L+ + + IG PV + ++ +VG +A +G+ ++I ++++SR ++Q
Sbjct: 469 LFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQ 528
Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
K ++QYM F K+ D R+ ++++ + K DE+ +L L + L+ EI IN +
Sbjct: 529 EKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQG-KMFDEESILGELSEPLREEI-INFNC 586
Query: 457 DTL-KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADD 515
L + +F + + + ++ KLR VF PGDYI ++G IGK+MY I G ++V+
Sbjct: 587 RKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG 646
Query: 516 GVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
+ L+DGSYFGEI +L + RRTA++R+ Y L+ LS D+ E L EYP
Sbjct: 647 --NKETKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPM 698
Query: 576 AKKALE 581
++A E
Sbjct: 699 MRRAFE 704
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 186 bits (471), Expect = 8e-47
Identities = 131/485 (27%), Positives = 241/485 (49%), Gaps = 40/485 (8%)
Query: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
GSQ+ ++ +++ K ++ P S+ + W + + + N ++ F Q+
Sbjct: 115 GSQKAVEK-EQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTT- 172
Query: 182 LMLWLVLDYSADVLYVLDVLVRARTGFLEQGL--MVSDTNRLWQHYKTTTQFKLDVLSLV 239
W++ + ++D +++LD+++ RTG + + ++ D + +Y + F +D +S +
Sbjct: 173 -TPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNY-LKSWFVVDFISSI 230
Query: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
P D +L V VRF RLL+ SRL + + E T
Sbjct: 231 PVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 290
Query: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
+ RI NL+ +L++ HW+ C+ F + F D WV N + + ++Y Y+
Sbjct: 291 LASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW--GKQYSYA 348
Query: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
L+ + + IG PV + ++ +VG +A VG+ ++I ++++SR ++Q
Sbjct: 349 LFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQ 408
Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
K ++QYM F K+ D+ ++ ++++ + K DE+ +L L D L+ EI
Sbjct: 409 EKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQG-KIFDEENILNELNDPLREEIVNFNCR 467
Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
+ + +F + + + ++ KLR VF PGDYI ++G +GK+MY I G V+
Sbjct: 468 KLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS- 526
Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
++ + L+DGSYFGEI +L KG RRTA++R+ Y L+ LS D+ E L EYP
Sbjct: 527 -SKEMKLTDGSYFGEICLLT-KG-----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMM 579
Query: 577 KKALE 581
++A E
Sbjct: 580 RRAFE 584
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 181 bits (460), Expect = 2e-45
Identities = 131/485 (27%), Positives = 236/485 (48%), Gaps = 40/485 (8%)
Query: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
GSQ+ +R +++ K A ++ P S+ + W + L + N L+I + E
Sbjct: 184 GSQKAVER-EQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGN--LIIIPVGITFFKDET 240
Query: 182 LMLWLVLDYSADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLV 239
W+V + +D +++D+++ RTG + + ++ D ++ + Y T F +D +S +
Sbjct: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSI 299
Query: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
P D +L V VRF RLL+ SRL + + E T
Sbjct: 300 PVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 359
Query: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
+ RI NL+ +L++ HW+ C+ F + F + WV N + + S Y ++
Sbjct: 360 LASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMV--NHSWSELYSFA 417
Query: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
L+ + + IG P + ++ +VG +A +G+ ++I ++++SR ++Q
Sbjct: 418 LFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQ 477
Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
K ++QYM F K+ D ++ ++++ + K DE +L L L+ EI
Sbjct: 478 EKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG-KMFDEDSILGELNGPLREEIVNFNCR 536
Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
+ + +F + + + ++ KL+ VF PGDYI ++G IGK+MY I G ++V+
Sbjct: 537 KLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG- 595
Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
+ + LSDGSYFGEI +L + RRTA++R+ Y L+ LS D+ E L EYP
Sbjct: 596 -NKEMKLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMM 648
Query: 577 KKALE 581
++A E
Sbjct: 649 RRAFE 653
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 181 bits (458), Expect = 3e-45
Identities = 132/500 (26%), Positives = 238/500 (47%), Gaps = 39/500 (7%)
Query: 132 RKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
+++ K A ++ P S+ + W + L + N +L F + E W+V +
Sbjct: 75 QERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNVL 132
Query: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 246
+D ++LD+++ RTG + E+G + R + T F +D++S +P D +L
Sbjct: 133 SDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVEL 192
Query: 247 ---------KVGTNYPEVRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 286
K VRF RLL+ SRL + + E T + RI
Sbjct: 193 EPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 252
Query: 287 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 346
NL+ +L++ HW+ C+ F + F D WV N + + R+Y ++L+ + +
Sbjct: 253 NLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMV--NHSWGRQYSHALFKAMSHML 310
Query: 347 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405
IG PV + ++ +VG +A +G+ ++I ++++SR ++Q K ++QY
Sbjct: 311 CIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 370
Query: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465
M F K+ D R+ ++++ + K DE+ +L L + L+ EI + + +F
Sbjct: 371 MSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEIINFTCRGLVAHMPLF 429
Query: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525
+ + ++ KLR VF PGD + ++G +G++MY I G L+V+A + L+D
Sbjct: 430 AHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTD 487
Query: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGR 585
GSYFGEI +L + RRTA++R+ Y L+ LS D L E+P ++A E
Sbjct: 488 GSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAM 541
Query: 586 QILMKDNLIDEELARAGADP 605
L++ + L R ++P
Sbjct: 542 DRLLRIGKKNSILQRKRSEP 561
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 163 bits (413), Expect = 4e-40
Identities = 112/409 (27%), Positives = 203/409 (49%), Gaps = 31/409 (7%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++++D+L+ RT ++ Q +VSD ++ HY F +D+++ +P DL
Sbjct: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 511
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
G++ LLK +RL Y G VL +L +I HW A
Sbjct: 512 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 567
Query: 301 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 347
CI++AI + TD W+ Y + + KY+ +LY++ +LT+
Sbjct: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627
Query: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
+G P + E +F + L+G L++A+I GNV ++I + + A + ++ +K+++
Sbjct: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687
Query: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 466
+F ++ L R+ +F + W +D VLK P+ L+A+I ++++ L+ + F+
Sbjct: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747
Query: 467 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 526
G L L +K + T PGD + GD+ +Y ++ G + ++ DD V +L
Sbjct: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805
Query: 527 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
FGE+ L K KS A++R++ Y DL + ++DL+E L YPE
Sbjct: 806 DIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 162 bits (410), Expect = 9e-40
Identities = 114/408 (27%), Positives = 202/408 (49%), Gaps = 31/408 (7%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++V+D+++ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
+ G++ LLK +RL Y G VL++L +I HW A
Sbjct: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416
Query: 301 CIYFAISKF--------IGF----GTDSWVYPNISIPEHG-RLSRKYIYSLYWSTLTLTT 347
CI++AI IG+ G N S P G + KY+ +LY++ +LT+
Sbjct: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
Query: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
+G P + E +F + L+G L++A+I GNV ++I + + A + ++ +K+++
Sbjct: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
Query: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 466
+F ++ L R+ +F + W+ +D VLK P+ L+A+I +++H L+ F
Sbjct: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
Query: 467 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 526
G L L +K + T PGD + GD+ +Y I+ G + ++ DD V +L
Sbjct: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKN 654
Query: 527 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 574
FGE L+ + KS +A++R++ Y DL + + DL+E L YP
Sbjct: 655 DIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 157 bits (398), Expect = 2e-38
Identities = 110/408 (26%), Positives = 200/408 (49%), Gaps = 33/408 (8%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++++D+L+ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
G+ LLK +RL Y G VL++L +I HW A
Sbjct: 173 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 225
Query: 301 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 348
CI++AI DS W++ I P + + KY+ +LY++ +LT++
Sbjct: 226 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 285
Query: 349 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 407
G P + E +F + L+G L++A+I GNV ++I + + A + ++ ++++++
Sbjct: 286 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 345
Query: 408 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 467
F ++ L R+ +F + W+ +D VLK P+ L+A+I ++++ L+ + F+
Sbjct: 346 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 405
Query: 468 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 527
G L L +K + T PGD + GD+ +Y I+ G + ++ D V +L
Sbjct: 406 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKND 463
Query: 528 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
FGE L + KS ++R++ Y DL + +DDL+E L YPE
Sbjct: 464 IFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 157 bits (398), Expect = 2e-38
Identities = 110/408 (26%), Positives = 200/408 (49%), Gaps = 33/408 (8%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++++D+L+ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
G+ LLK +RL Y G VL++L +I HW A
Sbjct: 513 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 565
Query: 301 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 348
CI++AI DS W++ I P + + KY+ +LY++ +LT++
Sbjct: 566 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 625
Query: 349 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 407
G P + E +F + L+G L++A+I GNV ++I + + A + ++ ++++++
Sbjct: 626 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 685
Query: 408 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 467
F ++ L R+ +F + W+ +D VLK P+ L+A+I ++++ L+ + F+
Sbjct: 686 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 745
Query: 468 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 527
G L L +K + T PGD + GD+ +Y I+ G + ++ D V +L
Sbjct: 746 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKND 803
Query: 528 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575
FGE L + KS ++R++ Y DL + +DDL+E L YPE
Sbjct: 804 IFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 155 bits (393), Expect = 9e-38
Identities = 132/515 (25%), Positives = 239/515 (46%), Gaps = 61/515 (11%)
Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
K++A P L+Y W I + FY L+ F Q+ + WLV+D
Sbjct: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256
Query: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 246
DV++++D+++ T F+ G ++SD + +Y T F +D+LS +P D+
Sbjct: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315
Query: 247 --KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWN 299
+ + + ++ RLL+ R+ D + G VL +L+ + HW
Sbjct: 316 DEGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGLAAHWM 366
Query: 300 ACIYFAISKFIGFGTD-------SWVYP---NISIPE--HGRLSRK----------YIYS 337
ACI+++I + F D SW+Y +I P +G S K YI S
Sbjct: 367 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 426
Query: 338 LYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
LY++ +LT++G P D E +F V ++G L++ATI GNV ++ M A+ +
Sbjct: 427 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 486
Query: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
++S++ +++ +V K L RV+ + W+ + +D ++VL+ P ++A+I ++++
Sbjct: 487 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 546
Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
K+ F+ G L L ++ + +PGD I G+ + + G L V+ DD
Sbjct: 547 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 606
Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
V +L G FG++ ++S AN+R++ Y DL + +D L + L Y
Sbjct: 607 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFYTAF 660
Query: 577 KKALEEKGRQILMKDNLIDEELARAGADPKDLEEK 611
+ R +++ NL + R +D K EE+
Sbjct: 661 SHSF---SRNLILTYNLRKRIVFRKISDVKREEEE 692
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 153 bits (387), Expect = 4e-37
Identities = 114/485 (23%), Positives = 228/485 (47%), Gaps = 33/485 (6%)
Query: 120 NVGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACF---DE 176
NV +PA + KK ++ S W I L FY + CF D+
Sbjct: 191 NVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDD 250
Query: 177 LQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDV 235
L + V D + ++L+++D+++ RT ++ + G ++ + + HY TT F +D+
Sbjct: 251 LSTTRSTT--VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY-VTTWFIIDL 307
Query: 236 LSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILII 295
++ +P DL Y T V + ++ RL + + + + + + L+ ++
Sbjct: 308 IAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV-LTLLMSMFALL 366
Query: 296 IHWNACIYFAISKFIGFGTD------SWVYP---NISIPEHGR-------LSRKYIYSLY 339
HW ACI++ I K W++ + P +G + YI +LY
Sbjct: 367 AHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALY 426
Query: 340 WSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
++ +LT++G D E +F + L+G L+ A + GNV ++I M + + + +
Sbjct: 427 FTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTR 486
Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
+K +++ + + L+ R++ +F W+ +D E+LK PD+L+++I ++++ +
Sbjct: 487 TKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEI 546
Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
L ++ +F+ G L L L ++ + +PG+Y+ ++GD + +Y + G + V+ D V
Sbjct: 547 L-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV- 604
Query: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE-AK 577
+L G G N+ + A+++++ Y DL C+ L E L YPE A
Sbjct: 605 -LAILGKGDLIG----ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAH 659
Query: 578 KALEE 582
K +E+
Sbjct: 660 KFVED 664
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 153 bits (386), Expect = 6e-37
Identities = 127/499 (25%), Positives = 238/499 (47%), Gaps = 39/499 (7%)
Query: 153 WLTAIALPVFYNWYLLICRACF--DELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLE 210
W I L FY + CF D+ LV D + ++L++LD+++ RT ++
Sbjct: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288
Query: 211 Q-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEF 269
Q G ++S + HY T F +D+++ +P DL Y+ T V + ++ RL
Sbjct: 289 QSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRL 347
Query: 270 FDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTD------SWV----- 318
+ E R + + + L+ ++ HW ACI++ I + D W+
Sbjct: 348 LQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGK 406
Query: 319 -----YPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVL 372
Y N S+ R S YI +LY++ +LT++G D E +F + L+G L
Sbjct: 407 RLEVPYVNGSVGGPSRRSA-YIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465
Query: 373 IFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKT 432
+ A + GNV ++I M + R+ + +++ +K +++ ++ + L+ R++ +F WA
Sbjct: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525
Query: 433 VDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYIC 492
+D E+L+ PD+L+A+IA++++ + L ++ +F G L L L ++ + +PG+Y+
Sbjct: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584
Query: 493 KKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSG--------N 544
++GD + Y + G L V+ D+ V +L G G + + G + G
Sbjct: 585 RRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVL 640
Query: 545 RRTANIRSIGYSDLFCLSKDDLMEALTEYPE---AKKALEEKGRQILMKDNLIDEELARA 601
+ +A+++++ Y L LS L E L YPE A +A + ++ L+R
Sbjct: 641 KTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF 700
Query: 602 GADPKDLEEKVEQLGSSLD 620
P+ + + E LGSS D
Sbjct: 701 SRSPRLSQPRSESLGSSSD 719
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 152 bits (385), Expect = 7e-37
Identities = 114/434 (26%), Positives = 201/434 (46%), Gaps = 54/434 (12%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V D + +VL++LD+++ RT F+ + G +V + HY TT F LDV++ +P DL +
Sbjct: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHY-VTTWFLLDVIAALPFDLLH 321
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFA 305
Y + ++ RL R + + Y + + L+ ++ HW AC++F
Sbjct: 322 AFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380
Query: 306 ISKF-----------IGF---------------------GTDSWVYPNISIPEHGR---- 329
I + IG+ G S N S
Sbjct: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440
Query: 330 -------LSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNV 381
L YI SLY++ +LT++G D E +F + L+G L+ A + GNV
Sbjct: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500
Query: 382 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 441
++I M A R + ++ ++ Y++ ++ K L+ R++ +F WA +D E+L+S
Sbjct: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560
Query: 442 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 501
LPD+L+A+IA+++H + L ++ +F+ G L L L LRP +PG+Y+ +GD + +
Sbjct: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619
Query: 502 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
Y + G + V+ G T +L G G + + + A+++ + Y L CL
Sbjct: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673
Query: 562 SKDDLMEALTEYPE 575
L ++L YPE
Sbjct: 674 QLAGLHDSLALYPE 687
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 150 bits (379), Expect = 4e-36
Identities = 128/513 (24%), Positives = 228/513 (44%), Gaps = 58/513 (11%)
Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
K++A P L+Y W I + FY ++ F Q+ + WLVLD
Sbjct: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253
Query: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246
DV++++D+++ T F+ G V +L + T F +D+LS +P D+
Sbjct: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313
Query: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300
+ + + ++ RLL+ R+ D + G VL +L+ + HW A
Sbjct: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364
Query: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339
CI+++I + DSW+Y +I P S Y+ SLY
Sbjct: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424
Query: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
++ +LTTIG P D E +F V +VG L++ATI GNV ++ M A+ +
Sbjct: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484
Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
+++++ +++ +V K L RV+ + W+ K +D ++VL P ++A+I ++++
Sbjct: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544
Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
+ F+ G L L ++ + +PGD I G+ + + G L V+ DD V
Sbjct: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 604
Query: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 578
+L G FG+I + AN+R++ Y DL + ++ L++ L Y
Sbjct: 605 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658
Query: 579 ALEEKGRQILMKDNLIDEELARAGADPKDLEEK 611
+ R + + NL + R +D K EE+
Sbjct: 659 SF---SRNLTLTCNLRKRIIFRKISDVKKEEEE 688
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 148 bits (373), Expect = 2e-35
Identities = 120/475 (25%), Positives = 214/475 (45%), Gaps = 55/475 (11%)
Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
K++A P L+Y W I + FY ++ F Q+ + WLVLD
Sbjct: 138 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 195
Query: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246
DV++++D+++ T F+ G V +L + T F +D+LS +P D+
Sbjct: 196 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 255
Query: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300
+ + + ++ RLL+ R+ D + G VL +L+ + HW A
Sbjct: 256 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 306
Query: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339
CI+++I + DSW+Y +I P S Y+ SLY
Sbjct: 307 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 366
Query: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
++ +LTTIG P D E +F V +VG L++ATI GNV ++ M A+ +
Sbjct: 367 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 426
Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
+++++ +++ +V K L RV+ + W+ K +D ++VL P ++A+I ++++
Sbjct: 427 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 486
Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
+ F+ G L L ++ + +PGD I G+ + + G L V+ DD V
Sbjct: 487 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 546
Query: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 573
+L G FG+I + AN+R++ Y DL + ++ L++ L Y
Sbjct: 547 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFY 595
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 147 bits (370), Expect = 4e-35
Identities = 135/542 (24%), Positives = 244/542 (45%), Gaps = 88/542 (16%)
Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
K++A P L+Y W I + FY L+ F Q+ + WLV+D
Sbjct: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256
Query: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL------- 243
DV++++D+++ T F+ G ++SD + +Y T F +D+LS +P D+
Sbjct: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315
Query: 244 ----AYL----KVG------------------TNYPEVRFNRLLKFSRLFEFFDRTETRT 277
A++ K+G + + ++ RLL+ R+ D
Sbjct: 316 DEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD------ 369
Query: 278 NYPNMFRIGNLVLYILIII-----HWNACIYFAISKFIGFGTD-------SWVYP---NI 322
+ G VL +L+ + HW ACI+++I + F D SW+Y +I
Sbjct: 370 ---HYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDI 426
Query: 323 SIPE--HGRLSRK----------YIYSLYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLV 369
P +G S K YI SLY++ +LT++G P D E +F V ++
Sbjct: 427 GTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMI 486
Query: 370 GVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWAN 429
G L++ATI GNV ++ M A+ + ++S++ +++ +V K L RV+ + W+
Sbjct: 487 GSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSM 546
Query: 430 KKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGD 489
+ +D ++VL+ P ++A+I ++++ K+ F+ G L L ++ + +PGD
Sbjct: 547 SRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGD 606
Query: 490 YICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTAN 549
I G+ + + G L V+ DD V +L G FG++ ++S AN
Sbjct: 607 LIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS----CAN 660
Query: 550 IRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLE 609
+R++ Y DL + +D L + L Y + R +++ NL + R +D K E
Sbjct: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISDVKREE 717
Query: 610 EK 611
E+
Sbjct: 718 EE 719
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 143 bits (360), Expect = 6e-34
Identities = 104/394 (26%), Positives = 183/394 (46%), Gaps = 56/394 (14%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++V+D+++ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
+ G++ LLK +RL Y G VL++L +I HW A
Sbjct: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416
Query: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360
CI S +GFG N+S P + E
Sbjct: 417 CICSLTS--VGFG-------NVS------------------------------PNTNSEK 437
Query: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420
+F + L+G L++A+I GNV ++I + + A + ++ +K++++F ++ L R+
Sbjct: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497
Query: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480
+F + W+ +D VLK P+ L+A+I +++H L+ F G L L +K
Sbjct: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557
Query: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540
+ T PGD + GD+ +Y I+ G + ++ DD V +L FGE L+ +
Sbjct: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615
Query: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 574
KS +A++R++ Y DL + + DL+E L YP
Sbjct: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 138 bits (347), Expect = 2e-32
Identities = 100/394 (25%), Positives = 189/394 (47%), Gaps = 31/394 (7%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++++D+L+ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
G+ LLK +RL Y G VL++L +I HW A
Sbjct: 513 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 565
Query: 301 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 348
CI++AI DS W++ I P + + KY+ +LY++ +LT++
Sbjct: 566 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 625
Query: 349 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 407
G P + E +F + L+G L++A+I GNV ++I + + A + ++ ++++++
Sbjct: 626 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 685
Query: 408 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 467
F ++ L R+ +F + W+ +D VLK P+ L+A+I ++++ L+ + F+
Sbjct: 686 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 745
Query: 468 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 527
G L L +K + T PGD + GD+ +Y I+ G + ++ D V + + G+
Sbjct: 746 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGA 805
Query: 528 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
G L + + S N++S+G CL
Sbjct: 806 GTG----LEMPSAASRGASLLNMQSLGLWTWDCL 835
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 133 bits (334), Expect = 6e-31
Identities = 106/419 (25%), Positives = 189/419 (45%), Gaps = 49/419 (11%)
Query: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191
K++A P L+Y W I + FY ++ F Q+ + WLVLD
Sbjct: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253
Query: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246
DV++++D+++ T F+ G V +L + T F +D+LS +P D+
Sbjct: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313
Query: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300
+ + + ++ RLL+ R+ D + G VL +L+ + HW A
Sbjct: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364
Query: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339
CI+++I + DSW+Y +I P S Y+ SLY
Sbjct: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424
Query: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
++ +LTTIG P D E +F V +VG L++ATI GNV ++ M A+ +
Sbjct: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484
Query: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
+++++ +++ +V K L RV+ + W+ K +D ++VL P ++A+I ++++
Sbjct: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544
Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGV 517
+ F+ G L L ++ + +PGD I G+ + + G L V+ DD V
Sbjct: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEV 603
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 93.2 bits (230), Expect = 7e-19
Identities = 70/276 (25%), Positives = 132/276 (47%), Gaps = 25/276 (9%)
Query: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
V+D D+++++D+L+ RT ++ Q +VSD ++ HY F +D+++ +P DL
Sbjct: 446 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 504
Query: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
G++ LLK +RL Y G VL +L +I HW A
Sbjct: 505 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 560
Query: 301 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 347
CI++AI + TD W+ Y + + KY+ +LY++ +LT+
Sbjct: 561 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 620
Query: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
+G P + E +F + L+G L++A+I GNV ++I + + A + ++ +K+++
Sbjct: 621 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 680
Query: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSL 442
+F ++ L R+ +F + W +D V S+
Sbjct: 681 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVCMSV 716
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 455 HLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD 514
+++ LK V FQ +L +L L T + G+YI ++G G +II++G + V +
Sbjct: 212 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 271
Query: 515 DGVTQFVV----LSDGSYFGEISILNIKGSKSGNRRTANI 550
D ++ V L G +FGE K + + RTAN+
Sbjct: 272 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 305
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 16/123 (13%)
Query: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525
++ E + E+V + P + I K+GD+G +Y++ +GK+ V + + +
Sbjct: 105 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 162
Query: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEAL--------TEYPEAK 577
G FGE++IL RTA ++++ L+ + + + TEY E
Sbjct: 163 GKVFGELAIL------YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFL 216
Query: 578 KAL 580
K++
Sbjct: 217 KSV 219
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 455 HLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD 514
+++ LK V FQ +L +L L T + G+YI ++G G +II++G + V +
Sbjct: 227 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 286
Query: 515 DGVTQFVV----LSDGSYFGEISILNIKGSKSGNRRTANI 550
D ++ V L G +FGE K + + RTAN+
Sbjct: 287 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 320
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 16/123 (13%)
Query: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525
++ E + E+V + P + I K+GD+G +Y++ +GK+ V + + +
Sbjct: 120 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 177
Query: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEAL--------TEYPEAK 577
G FGE++IL RTA ++++ L+ + + + TEY E
Sbjct: 178 GKVFGELAIL------YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFL 231
Query: 578 KAL 580
K++
Sbjct: 232 KSV 234
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 13/129 (10%)
Query: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVV----AD 514
L+ V + ++ L +++ L + GDYI ++G+ G +I+ +GK+ V
Sbjct: 281 LRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340
Query: 515 DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL--SKDDLMEALTE 572
D L G YFGE +++ S + R+ANI + +D+ CL ++ + +
Sbjct: 341 DQPQLIKTLQKGEYFGEKALI------SDDVRSANIIA-EENDVACLVIDRETFNQTVGT 393
Query: 573 YPEAKKALE 581
+ E +K LE
Sbjct: 394 FEELQKYLE 402
Score = 37.0 bits (84), Expect = 0.060
Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 11/138 (7%)
Query: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
D L K + + + + ++V + + G YI K+G+ G ++++ EG+L V +
Sbjct: 161 DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEK 220
Query: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
+ + + + FGE++IL RTA++++I + L ++ + +A
Sbjct: 221 LLSSIPM--WTTFGELAIL------YNCTRTASVKAITNVKTWALDREVFQNIMRRTAQA 272
Query: 577 KKALEEKGRQILMKDNLI 594
+ +E+ R L +L+
Sbjct: 273 R---DEQYRNFLRSVSLL 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,898,795
Number of Sequences: 37866
Number of extensions: 1018367
Number of successful extensions: 4079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 3704
Number of HSP's gapped (non-prelim): 344
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.