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Search of human proteins with 12007646
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12007646 nyctalopin precursor [Homo sapiens]
(481 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12007646 nyctalopin precursor [Homo sapiens] 957 0.0
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 143 3e-34
gi|153251229 chondroadherin precursor [Homo sapiens] 139 6e-33
gi|198041768 synleurin [Homo sapiens] 139 7e-33
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 135 6e-32
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 135 6e-32
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 134 2e-31
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 133 3e-31
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 132 5e-31
gi|194440719 chondroadherin-like [Homo sapiens] 132 9e-31
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 131 2e-30
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 127 2e-29
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 126 5e-29
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 121 1e-27
gi|225579152 insulin-like growth factor binding protein, acid la... 121 2e-27
gi|4826772 insulin-like growth factor binding protein, acid labi... 121 2e-27
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 120 3e-27
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 116 4e-26
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 116 5e-26
gi|188528675 slit homolog 1 [Homo sapiens] 115 1e-25
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 114 2e-25
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 114 2e-25
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 112 1e-24
gi|51317373 netrin-G1 ligand [Homo sapiens] 112 1e-24
gi|11321571 slit homolog 3 [Homo sapiens] 111 2e-24
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 110 2e-24
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 110 2e-24
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 109 5e-24
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 108 1e-23
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 108 1e-23
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 957 bits (2473), Expect = 0.0
Identities = 481/481 (100%), Positives = 481/481 (100%)
Query: 1 MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL 60
MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL
Sbjct: 1 MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL 60
Query: 61 PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 120
PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN
Sbjct: 61 PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 120
Query: 121 GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG 180
GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG
Sbjct: 121 GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG 180
Query: 181 LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240
LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN
Sbjct: 181 LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240
Query: 241 LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQN 300
LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQN
Sbjct: 241 LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQN 300
Query: 301 LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDV 360
LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDV
Sbjct: 301 LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDV 360
Query: 361 PCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKL 420
PCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKL
Sbjct: 361 PCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKL 420
Query: 421 LAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQM 480
LAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQM
Sbjct: 421 LAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQM 480
Query: 481 D 481
D
Sbjct: 481 D 481
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 143 bits (361), Expect = 3e-34
Identities = 124/374 (33%), Positives = 166/374 (44%), Gaps = 39/374 (10%)
Query: 28 ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPS 87
A CPA C C+ R +V C R L VP +P E ++L RN +R L LP+
Sbjct: 22 AGGCPARCECTVQTR--AVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79
Query: 88 LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRL 147
L L L N ++ + PGAF LPRL LRL N L+ + F L L LDL+ +L
Sbjct: 80 LEELDLSENAIAHVEPGAFANLPRLRVLRLRGN-QLKLIPPGVFTRLDNLTLLDLSENKL 138
Query: 148 FSVPERLLAELPALRELAAFDN----LFRRVPGALRGLANLTHAHLERGRIEAVASSSLQ 203
+ + +L +LR L DN + RR A GL L LER + A++ SL
Sbjct: 139 VILLDYTFQDLHSLRRLEVGDNDLVFVSRR---AFAGLLALEELTLERCNLTALSGESLG 195
Query: 204 GLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLL-NDNLLAELPADAFRGLR-------- 254
LR L +L L+ + ++ F L HL + N LL E+ A + RGL
Sbjct: 196 HLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTH 255
Query: 255 ---------------RLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 299
L LNL N + V R F DL L L+L +A VE AF
Sbjct: 256 TNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFL 315
Query: 300 NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWL---RDWMEGSGR 356
L + L+L+ N L+ L F L L + NP CDCRL W+ R + GR
Sbjct: 316 GLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGR 375
Query: 357 VTDVPCASPGSVAG 370
+ CA+P V G
Sbjct: 376 LP--ACATPAEVRG 387
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 139 bits (350), Expect = 6e-33
Identities = 116/379 (30%), Positives = 169/379 (44%), Gaps = 37/379 (9%)
Query: 4 RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCE 63
R ML+L L ++ GL A A ACP C C + + V CD+ GL ++P ++ +
Sbjct: 3 RPMLLLSL-GLLAGLLPALA------ACPQNCHCHSDLQ--HVICDKVGLQKIP-KVSEK 52
Query: 64 AVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDL 123
++L RN L +F +P+L L L+H + + GAF+GL +L L L+HN D+
Sbjct: 53 TKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DI 111
Query: 124 RYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLAN 183
R L A F L+ L L L ++ +P LL+ L N
Sbjct: 112 RVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPL-----------------------VN 148
Query: 184 LTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLA 243
L L +I + + + QG + LR L L N + ++ GA D L ++ N L+
Sbjct: 149 LFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLS 208
Query: 244 ELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAE-LELLYLDRNSIAFVEEGAFQNLS 302
P+ A LR + L L N L + F LE L+LD ++ +GAF ++
Sbjct: 209 SYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVT 268
Query: 303 GLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPC 362
L +HL NRL L + P L L L NPW C C+L LR W+E D C
Sbjct: 269 TLKHVHLENNRLNQLP--SNFPFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDATC 326
Query: 363 ASPGSVAGLDLSQVTFGRS 381
ASP G + RS
Sbjct: 327 ASPAKFKGQHIRDTDAFRS 345
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 139 bits (349), Expect = 7e-33
Identities = 115/396 (29%), Positives = 175/396 (44%), Gaps = 43/396 (10%)
Query: 7 LVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVS 66
L+LLLH +LG C + C T G + C GL +P P V
Sbjct: 21 LLLLLHKEILG-------------CSSVCQLCT---GRQINCRNLGLSSIPKNFPESTVF 64
Query: 67 IDLDRNGLRFLGE------------------------RAFGTLPSLRRLSLRHNNLSFIT 102
+ L N + ++ E +AF L L L L +N + +
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 103 PGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALR 162
PG FKGL L L L +N + ++ F L ++ L+L RL + + ALR
Sbjct: 125 PGIFKGLLNLRNLYLQYN-QVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALR 183
Query: 163 EL-AAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAV 221
L + +N+ R + L NL +L + V S++ + L+ LR LSL N + A+
Sbjct: 184 ILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAI 243
Query: 222 HAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELE 281
AF LE+LLL ++ + + D F G+ L+ L L N L+ + F+ L L
Sbjct: 244 QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLI 303
Query: 282 LLYLDRNSIAFVEEGAFQNL-SGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCC 340
L LDRN I ++ F+N+ + L L+L+ N LT L +P L L NPW C
Sbjct: 304 YLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWEC 363
Query: 341 DCRLEWLRDWMEGSGRVTDVPCASPGSVAGLDLSQV 376
+C+L LRDW+ S ++ C +P S+ G L +
Sbjct: 364 NCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYI 399
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 135 bits (341), Expect = 6e-32
Identities = 138/517 (26%), Positives = 204/517 (39%), Gaps = 115/517 (22%)
Query: 21 AWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGER 80
AW G CP+ C CS R V C A ++ VP LP A+S+ + + L E
Sbjct: 21 AWGAGLAYHGCPSECTCS---RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNES 77
Query: 81 AFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRL 140
F + +L L + N LS ITPGAF+ L L L LA+N L+ L F L L L
Sbjct: 78 PFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANN-KLQVLPIGLFQGLDSLESL 136
Query: 141 DLAACRLFSVPERLLAELPALREL------------AAFDNLFRRV-------------P 175
L++ +L + ++ L+EL AFD+L P
Sbjct: 137 LLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISP 196
Query: 176 GALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHL 235
+ L NL L R+ + + GL L+ L+LQ N++ + G F + L+ L
Sbjct: 197 RVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRL 256
Query: 236 LLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA-----------RAW----------- 273
L++N +++LP F L +L L L GN+L ++ W
Sbjct: 257 YLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPD 316
Query: 274 --FADLAELELLYLDRNSIAFVEEGAFQ-------------------------------- 299
F++L +L++L L RN I+F+ GAF
Sbjct: 317 NVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 376
Query: 300 ----------------NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCR 343
N++GL+A+ L N+L L F L L L+ NPW CD
Sbjct: 377 SLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSD 436
Query: 344 LEWLRDWM----EGSGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNL--TTS 397
+ LR+W+ G T C SP +V G L + + + V PE + T
Sbjct: 437 ILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHV-PEVPSYPETPW 495
Query: 398 SPGPSPEPAATTVSRFSSLLSKLLAPRVPVEEAANTT 434
P P T+VS + L S PVE+ + T
Sbjct: 496 YPDTPSYPDTTSVSSTTELTS-------PVEDYTDLT 525
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 135 bits (341), Expect = 6e-32
Identities = 138/517 (26%), Positives = 204/517 (39%), Gaps = 115/517 (22%)
Query: 21 AWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGER 80
AW G CP+ C CS R V C A ++ VP LP A+S+ + + L E
Sbjct: 15 AWGAGLAYHGCPSECTCS---RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNES 71
Query: 81 AFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRL 140
F + +L L + N LS ITPGAF+ L L L LA+N L+ L F L L L
Sbjct: 72 PFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANN-KLQVLPIGLFQGLDSLESL 130
Query: 141 DLAACRLFSVPERLLAELPALREL------------AAFDNLFRRV-------------P 175
L++ +L + ++ L+EL AFD+L P
Sbjct: 131 LLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISP 190
Query: 176 GALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHL 235
+ L NL L R+ + + GL L+ L+LQ N++ + G F + L+ L
Sbjct: 191 RVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRL 250
Query: 236 LLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA-----------RAW----------- 273
L++N +++LP F L +L L L GN+L ++ W
Sbjct: 251 YLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPD 310
Query: 274 --FADLAELELLYLDRNSIAFVEEGAFQ-------------------------------- 299
F++L +L++L L RN I+F+ GAF
Sbjct: 311 NVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNI 370
Query: 300 ----------------NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCR 343
N++GL+A+ L N+L L F L L L+ NPW CD
Sbjct: 371 SLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSD 430
Query: 344 LEWLRDWM----EGSGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNL--TTS 397
+ LR+W+ G T C SP +V G L + + + V PE + T
Sbjct: 431 ILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHV-PEVPSYPETPW 489
Query: 398 SPGPSPEPAATTVSRFSSLLSKLLAPRVPVEEAANTT 434
P P T+VS + L S PVE+ + T
Sbjct: 490 YPDTPSYPDTTSVSSTTELTS-------PVEDYTDLT 519
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 134 bits (336), Expect = 2e-31
Identities = 134/472 (28%), Positives = 192/472 (40%), Gaps = 46/472 (9%)
Query: 4 RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL--- 60
R + +LL+ L LP CP C C + + C GL VP
Sbjct: 5 RALRLLLVVCGCLALPPL-----AEPVCPERCDCQHPQH---LLCTNRGLRVVPKTSSLP 56
Query: 61 -PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAH 119
P + ++ L N + + F L LRRL L++N + + P F+ L RL EL L +
Sbjct: 57 SPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGN 116
Query: 120 NGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALR 179
N L+ L T A L +LR L + + L +L +L N +P A+
Sbjct: 117 NL-LQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVF 175
Query: 180 G-LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAV--HAGAFGDCGVLEHLL 236
L NL + HLE RI + ++ L +LR L+L AN ++ HA F L L+
Sbjct: 176 APLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLI 235
Query: 237 LN------------------------DNLLAELPADAFRGLRRLRTLNLGGNALDRVARA 272
L+ N L L +AF GL LR L L GN L ++ A
Sbjct: 236 LSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTA 295
Query: 273 WFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLF 332
L LE L L N ++ + F +L L L L N L+ L+ F L RL
Sbjct: 296 LLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLD 355
Query: 333 LFRNPWCCDCRLEWLRDWM---EGSGRVTD--VPCASPGSVAGLDLSQVTFGRSSDGLCV 387
L N W CDCRL L+ WM GR+ V C P ++ G L + + +G C
Sbjct: 356 LDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCA 415
Query: 388 DPEELNLTTSSPGPSPEPAATTVSRFSSL-LSKLLAPRVPVEEAANTTGGLA 438
DP T+ P P A L++ L P+ +++ G+A
Sbjct: 416 DPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVA 467
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 133 bits (335), Expect = 3e-31
Identities = 126/400 (31%), Positives = 171/400 (42%), Gaps = 46/400 (11%)
Query: 45 SVRCDRAGLLRVPAELPCEAVSID---LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFI 101
++R R + +P L + V ++ LD N LR + + F L +L+ L+L N L F+
Sbjct: 102 TLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFL 161
Query: 102 TPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPAL 161
F L L L L+ N +L +L A ++L RL L + RL S+ LL L AL
Sbjct: 162 PASLFTNLENLKLLDLSGN-NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGAL 220
Query: 162 RELAAFDNLFRRV-PGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRA 220
EL N R + PGA L NL+ L R + + S+ L L+L N +
Sbjct: 221 TELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAE 280
Query: 221 VHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLG-GNALDRVARAWFADLAE 279
+ FG+ G L+ L LN L LPA AFR L RLR L + L + + F L E
Sbjct: 281 LPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGE 340
Query: 280 LELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQ---------------- 323
L++L L N + + +G + L L + L NRL L F+
Sbjct: 341 LQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE 400
Query: 324 --PGFFLGRL------FLFRNPWCCDCR----LEWLRDWMEGSGRVTDVPCASPGSVAGL 371
PG G L L N W CDC L WLR + G CA PG+ AGL
Sbjct: 401 TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGL 460
Query: 372 DLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVS 411
L + G D C P GP P PAA + S
Sbjct: 461 PLWALPGG---DAECPGPR---------GPPPRPAADSSS 488
Score = 68.6 bits (166), Expect = 1e-11
Identities = 50/162 (30%), Positives = 69/162 (42%)
Query: 175 PGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEH 234
PG L L L R +I + + L + L L L N +R + F L+
Sbjct: 91 PGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQE 150
Query: 235 LLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVE 294
L LN N L LPA F L L+ L+L GN L + + A+LE L L N + ++
Sbjct: 151 LALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLD 210
Query: 295 EGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
G +L L L + N + +A AF L L L RN
Sbjct: 211 SGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRN 252
Score = 62.8 bits (151), Expect = 7e-10
Identities = 50/154 (32%), Positives = 68/154 (44%)
Query: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
NLTH L + S S G+ L+ L + + + AV G F D L+ L L+ N +
Sbjct: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
Query: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLS 302
LP + L L L NAL + + F L L+ L L++N + F+ F NL
Sbjct: 111 THLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLE 170
Query: 303 GLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
L L L+GN LT L L RL L N
Sbjct: 171 NLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSN 204
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 132 bits (333), Expect = 5e-31
Identities = 124/435 (28%), Positives = 168/435 (38%), Gaps = 86/435 (19%)
Query: 18 LPSAWAVGAC-------ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLD 70
LP AW + A+ CP C C E V C L VP ++P +I
Sbjct: 2 LPGAWLLWTSLLLLARPAQPCPMGCDCFVQE----VFCSDEELATVPLDIPPYTKNIIFV 57
Query: 71 RNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLA------------ 118
L RAFG+ P+L ++ + L P AF GLPRL +L +
Sbjct: 58 ETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIF 117
Query: 119 -------------------------HNGDLRYLHA----------RTFAALSRLRRLDLA 143
H L LH R F L+ L+ L+LA
Sbjct: 118 SNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLA 177
Query: 144 ACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG----------------------- 180
L +PE L L +L+ L +N +P + G
Sbjct: 178 QNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVF 237
Query: 181 --LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLN 238
L L L+R I + S L L LSLQ N +R + AG F L L L
Sbjct: 238 SQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLT 297
Query: 239 DNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAF 298
N L + F L LR+L L NA+ + F DL EL LYL N++ + F
Sbjct: 298 HNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALF 357
Query: 299 QNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG-SGRV 357
QNLS L L L+ N+LT L F + L L L NPW CDC L +L +W++ + R+
Sbjct: 358 QNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL 417
Query: 358 TDVP--CASPGSVAG 370
++ CA P + G
Sbjct: 418 LNIQTYCAGPAYLKG 432
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 132 bits (331), Expect = 9e-31
Identities = 114/343 (33%), Positives = 150/343 (43%), Gaps = 32/343 (9%)
Query: 31 CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRR 90
CP AC C R S C+ GL VP P + +DL RN + AF L L
Sbjct: 396 CPRACVCVPESRHSS--CEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVS 453
Query: 91 LSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSV 150
L L+H ++ + GA GL RL L L+ N +L L AA
Sbjct: 454 LHLQHCGIAELEAGALAGLGRLIYLYLSDN---------------QLAGLSAAA------ 492
Query: 151 PERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGLRRLR 209
L P L L N F +VPG ALR L +L HL+ ++ +A L R LR
Sbjct: 493 ----LEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALR 548
Query: 210 SLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRV 269
+ L NR+ V GA G LE L L+ N L E+P A GL L L L GN L +
Sbjct: 549 WVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRAL 608
Query: 270 ARAWFADLA-ELELLYLDRNSIAFVEEGAFQNLS-GLLALHLNGNRLTVLAWVAFQPGFF 327
F + L+ L+L+ + + + GAF L GL +LHL N+L L A
Sbjct: 609 RDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQ 666
Query: 328 LGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAG 370
L + L NP+ CDC+L L W+ G CA+P + G
Sbjct: 667 LELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGATCATPPNARG 709
Score = 119 bits (299), Expect = 5e-27
Identities = 115/364 (31%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 7 LVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVS 66
LVL L ++L P A A A+ CP AC C R V C L VP +P
Sbjct: 12 LVLPLLVLLLLAP---ARQAAAQRCPQACICDNSRR--HVACRYQNLTEVPDAIPELTQR 66
Query: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
+DL N L+ + AF +P L L LRH + + GAF+GL RL L LA N LR L
Sbjct: 67 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN-HLREL 125
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
L LRRL+L E AL EL PG L L
Sbjct: 126 PQEALDGLGSLRRLEL--------------EGNALEELR---------PGTFGALGALAT 162
Query: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELP 246
+L + + + + QGL R+R L L N + + A L L L+ N L LP
Sbjct: 163 LNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALP 222
Query: 247 ADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLA 306
R L L LG N L L L L LD ++ + AF + L
Sbjct: 223 GPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHT 282
Query: 307 LHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPG 366
L L GN+L L Q L RL L NP C C+ L +W+ + +D C P
Sbjct: 283 LDLRGNQLDTLP--PLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPR 340
Query: 367 SVAG 370
+ G
Sbjct: 341 RLRG 344
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 131 bits (329), Expect = 2e-30
Identities = 120/392 (30%), Positives = 168/392 (42%), Gaps = 40/392 (10%)
Query: 6 MLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAV 65
+L+L+L +V+ G A CP C CS +R +V C R + VP +P E
Sbjct: 26 ILLLVLGSVLSG---------SATGCPPRCECSAQDR--AVLCHRKRFVAVPEGIPTETR 74
Query: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
+DL +N ++ L + F + P L L L N +S + PGAF L L L L N L+
Sbjct: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR-LKL 133
Query: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDN----LFRRVPGALRGL 181
+ F LS L +LD++ ++ + + + +L L+ L DN + R L L
Sbjct: 134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
Query: 182 ANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLE-------- 233
LT I A S L GL LR L N +R VLE
Sbjct: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLD 253
Query: 234 ----HLLLNDNL---------LAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL 280
+ L NL L +P A R L LR LNL N + + + +L L
Sbjct: 254 TMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRL 313
Query: 281 ELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCC 340
+ + L +A VE AF+ L+ L L+++GN+LT L F L L L NP C
Sbjct: 314 QEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLAC 373
Query: 341 DCRLEWL--RDWMEGSGRVTDVPCASPGSVAG 370
DCRL W+ R W R CA+P V G
Sbjct: 374 DCRLLWVFRRRWRLNFNR-QQPTCATPEFVQG 404
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 127 bits (320), Expect = 2e-29
Identities = 101/342 (29%), Positives = 155/342 (45%), Gaps = 28/342 (8%)
Query: 31 CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRR 90
CPA C CS + SV C R L+ +P +P E +DL +N L+ + F + P L
Sbjct: 28 CPARCECSAQNK--SVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
Query: 91 LSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSV 150
+ L N ++ + PGAF L L LRL N L+ + F LS L +LD++ ++ +
Sbjct: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNR-LKLVPLGVFTGLSNLTKLDISENKIVIL 144
Query: 151 PERLLAELPALRELAAFDN-LFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLR 209
+ + +L L+ L DN L A GL +L LE+ + AV + +L LR L
Sbjct: 145 LDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI 204
Query: 210 SLSLQANRVRAVHAGAFGDCGVLEHLLLN------------------------DNLLAEL 245
SL L+ + + AF L+HL ++ + L+ +
Sbjct: 205 SLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTV 264
Query: 246 PADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLL 305
P AF+ L L LNL N + + F+DL L+ L++ + +E +FQ L L
Sbjct: 265 PFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLR 324
Query: 306 ALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWL 347
L+++ N L L F L L + NP CDCRL W+
Sbjct: 325 VLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWI 366
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 126 bits (316), Expect = 5e-29
Identities = 118/377 (31%), Positives = 160/377 (42%), Gaps = 29/377 (7%)
Query: 25 GACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGT 84
G +CPA C C++ + +V C L VP LP + +DL N L L +
Sbjct: 25 GGSGGSCPAVCDCTSQPQ--AVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSR 82
Query: 85 LPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAA 144
L L+ L L +N LS + PGAF GL L LRL N LR + F+ LS L LDL
Sbjct: 83 LSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGN-RLRIMGPGVFSGLSALTLLDLRL 141
Query: 145 CRLFSVPERLLAELPALRELAAFDN-LFRRVPGALRGLANLTHAHLERGRIEAVASSSLQ 203
++ + EL +L++L DN L PGA GLA L+ LER + V +L
Sbjct: 142 NQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALA 201
Query: 204 GLRRLRSLSLQANRVRAVHAGAFGDCGVLEHL---------------LLNDNL------- 241
L L +L L+ + + AGA G L+ L L+ NL
Sbjct: 202 RLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITR 261
Query: 242 --LAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 299
L+ +P A L LR L+L N + + + L L+ L L + + AF
Sbjct: 262 CNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFH 321
Query: 300 NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEW-LRDWMEGSGRVT 358
L+ L + N L L AF L L L NP CDCRL W LR ++
Sbjct: 322 GLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMS 381
Query: 359 DVPCASPGSVAGLDLSQ 375
CA P V G L +
Sbjct: 382 PPACAGPHHVQGKSLKE 398
Score = 59.7 bits (143), Expect = 6e-09
Identities = 60/202 (29%), Positives = 81/202 (40%), Gaps = 37/202 (18%)
Query: 211 LSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA 270
L L NR+ + G +L+ L L+ N L+ L AF GL+ L TL L GN L +
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 271 RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQ------- 323
F+ L+ L LL L N I +GAF L L L + N L +A AF
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 324 -----------PGFFLGRLFLFRNPWCCDCRLEWL------RDWMEGSGRVTDVP----- 361
PG L RL P RL L + G G++ ++
Sbjct: 185 LTLERCNLSTVPGLALARL-----PALVALRLRELDIGRLPAGALRGLGQLKELEIHLWP 239
Query: 362 ---CASPGSVAGLDLSQVTFGR 380
PGS+ GL+LS + R
Sbjct: 240 SLEALDPGSLVGLNLSSLAITR 261
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 121 bits (304), Expect = 1e-27
Identities = 91/245 (37%), Positives = 113/245 (46%), Gaps = 5/245 (2%)
Query: 21 AWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGER 80
AW V A CP AC C E + C + GL VP +P + I L N + +
Sbjct: 20 AWQVAA---PCPGACVCYN-EPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAA 75
Query: 81 AFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRL 140
+F +L L L N L+ I AF GL L +L L+ N LR + TF L RL L
Sbjct: 76 SFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTL 135
Query: 141 DLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHAHLERGRIEAVAS 199
L C L + L L AL+ L DN + +P R L NLTH L RI +V
Sbjct: 136 HLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPE 195
Query: 200 SSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTL 259
+ +GL L L L NRV VH AF D G L L L N L+ LP +A LR L+ L
Sbjct: 196 RAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYL 255
Query: 260 NLGGN 264
L N
Sbjct: 256 RLNDN 260
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 121 bits (303), Expect = 2e-27
Identities = 118/378 (31%), Positives = 156/378 (41%), Gaps = 58/378 (15%)
Query: 3 GRGMLVLLLHAVVLGLPSAWAVG------ACARACPAACACSTVERG--CSVRCDRAGLL 54
G + +LLL V LG S A ACPAAC CS + SV C L
Sbjct: 45 GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 104
Query: 55 RVPAELP--CEAVSID-------------------------------------------- 68
R+P +P +A+ +D
Sbjct: 105 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 164
Query: 69 --LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
L+RN LR L F P+L L L +N LS + G F+GL L +L L N L L
Sbjct: 165 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS-LAVL 223
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLT 185
F L LR L LA RL + L + L LREL N R + L L
Sbjct: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 283
Query: 186 HAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAEL 245
+L+R I AVA + GL+ LR L L NRV + F L L L+ N +A L
Sbjct: 284 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
Query: 246 PADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLL 305
F+ L L L LG N + ++A F L +LE+L LD N + V+ GAF L+ +
Sbjct: 344 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
Query: 306 ALHLNGNRLTVLAWVAFQ 323
++L+GN L L F+
Sbjct: 404 VMNLSGNCLRNLPEQVFR 421
Score = 112 bits (281), Expect = 6e-25
Identities = 91/274 (33%), Positives = 124/274 (45%), Gaps = 26/274 (9%)
Query: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
S+ L N L L + F L SL L+L N+L+ + AF+GL L EL LA N L Y
Sbjct: 188 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR-LAY 246
Query: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANL 184
L F+ L+ LR LDL+ L ++ + +LP L++L NL V PGA GL L
Sbjct: 247 LQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKAL 306
Query: 185 THAHLERGRIEAVASSSLQGLRRLR------------------------SLSLQANRVRA 220
L R+ + + GL LR L L NR+R
Sbjct: 307 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 366
Query: 221 VHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL 280
+ +F G LE L L+ N L E+ A AF GL + +NL GN L + F L +L
Sbjct: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
Query: 281 ELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 314
L+L+ + + + F LSGL L L N L
Sbjct: 427 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Score = 111 bits (277), Expect = 2e-24
Identities = 98/331 (29%), Positives = 142/331 (42%), Gaps = 51/331 (15%)
Query: 69 LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128
L N + L R F L L L L HN + + +F+GL +L L L HN L+ + A
Sbjct: 335 LSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN-QLQEVKA 393
Query: 129 RTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHA 187
F L+ + ++L+ L ++PE++ L L L + R+ P GL+ L
Sbjct: 394 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 453
Query: 188 HLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPA 247
L+ + + SL GL L L L +N++ + F G LE+LLL+ N LAELPA
Sbjct: 454 FLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA 513
Query: 248 DAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLAL 307
DA L+R L++ N L+ + + A L L L L NS+
Sbjct: 514 DALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR---------------- 557
Query: 308 HLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDW---------------ME 352
+ PG L RL+L NPW C C L+ LRD+ E
Sbjct: 558 ----------TFTPQPPG--LERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICE 605
Query: 353 GSG------RVTDVPCASPGSVAGLDLSQVT 377
G ++ CASP V GLDL ++
Sbjct: 606 GDDCQPPAYTYNNITCASPPEVVGLDLRDLS 636
Score = 32.0 bits (71), Expect = 1.3
Identities = 24/62 (38%), Positives = 30/62 (48%), Gaps = 8/62 (12%)
Query: 58 AELPCEAVS-------IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLP 110
AELP +A+ +D+ N L L L LR LSLR+N+L TP GL
Sbjct: 509 AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP-PGLE 567
Query: 111 RL 112
RL
Sbjct: 568 RL 569
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 121 bits (303), Expect = 2e-27
Identities = 118/378 (31%), Positives = 156/378 (41%), Gaps = 58/378 (15%)
Query: 3 GRGMLVLLLHAVVLGLPSAWAVG------ACARACPAACACSTVERG--CSVRCDRAGLL 54
G + +LLL V LG S A ACPAAC CS + SV C L
Sbjct: 7 GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 66
Query: 55 RVPAELP--CEAVSID-------------------------------------------- 68
R+P +P +A+ +D
Sbjct: 67 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 126
Query: 69 --LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
L+RN LR L F P+L L L +N LS + G F+GL L +L L N L L
Sbjct: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS-LAVL 185
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLT 185
F L LR L LA RL + L + L LREL N R + L L
Sbjct: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
Query: 186 HAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAEL 245
+L+R I AVA + GL+ LR L L NRV + F L L L+ N +A L
Sbjct: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
Query: 246 PADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLL 305
F+ L L L LG N + ++A F L +LE+L LD N + V+ GAF L+ +
Sbjct: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
Query: 306 ALHLNGNRLTVLAWVAFQ 323
++L+GN L L F+
Sbjct: 366 VMNLSGNCLRNLPEQVFR 383
Score = 112 bits (281), Expect = 6e-25
Identities = 91/274 (33%), Positives = 124/274 (45%), Gaps = 26/274 (9%)
Query: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
S+ L N L L + F L SL L+L N+L+ + AF+GL L EL LA N L Y
Sbjct: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR-LAY 208
Query: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANL 184
L F+ L+ LR LDL+ L ++ + +LP L++L NL V PGA GL L
Sbjct: 209 LQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKAL 268
Query: 185 THAHLERGRIEAVASSSLQGLRRLR------------------------SLSLQANRVRA 220
L R+ + + GL LR L L NR+R
Sbjct: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328
Query: 221 VHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL 280
+ +F G LE L L+ N L E+ A AF GL + +NL GN L + F L +L
Sbjct: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
Query: 281 ELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 314
L+L+ + + + F LSGL L L N L
Sbjct: 389 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Score = 111 bits (277), Expect = 2e-24
Identities = 98/331 (29%), Positives = 142/331 (42%), Gaps = 51/331 (15%)
Query: 69 LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128
L N + L R F L L L L HN + + +F+GL +L L L HN L+ + A
Sbjct: 297 LSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN-QLQEVKA 355
Query: 129 RTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHA 187
F L+ + ++L+ L ++PE++ L L L + R+ P GL+ L
Sbjct: 356 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
Query: 188 HLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPA 247
L+ + + SL GL L L L +N++ + F G LE+LLL+ N LAELPA
Sbjct: 416 FLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA 475
Query: 248 DAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLAL 307
DA L+R L++ N L+ + + A L L L L NS+
Sbjct: 476 DALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR---------------- 519
Query: 308 HLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDW---------------ME 352
+ PG L RL+L NPW C C L+ LRD+ E
Sbjct: 520 ----------TFTPQPPG--LERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICE 567
Query: 353 GSG------RVTDVPCASPGSVAGLDLSQVT 377
G ++ CASP V GLDL ++
Sbjct: 568 GDDCQPPAYTYNNITCASPPEVVGLDLRDLS 598
Score = 32.0 bits (71), Expect = 1.3
Identities = 24/62 (38%), Positives = 30/62 (48%), Gaps = 8/62 (12%)
Query: 58 AELPCEAVS-------IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLP 110
AELP +A+ +D+ N L L L LR LSLR+N+L TP GL
Sbjct: 471 AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP-PGLE 529
Query: 111 RL 112
RL
Sbjct: 530 RL 531
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 120 bits (301), Expect = 3e-27
Identities = 103/308 (33%), Positives = 134/308 (43%), Gaps = 6/308 (1%)
Query: 5 GMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEA 64
G L LL + L SA GA C A C+C R V C GL VP L
Sbjct: 3 GPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRR---VDCSGKGLTAVPEGLSAFT 59
Query: 65 VSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLR 124
++D+ N + L E AF P L L L N+LSFI P A GL L L L N L+
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL-QNNQLK 118
Query: 125 YLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLAN 183
+ + LS L+ L L A + SVPE L LR L DN VP L L
Sbjct: 119 TVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPT 178
Query: 184 LTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLA 243
L L +I ++ + L L L L N++R++ F LE L LN N L
Sbjct: 179 LQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG 238
Query: 244 ELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSG 303
E P A + L L+ L N++ + F L ++L N ++FV AF NLS
Sbjct: 239 EFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297
Query: 304 LLALHLNG 311
L +L + G
Sbjct: 298 LHSLVIRG 305
Score = 85.9 bits (211), Expect = 7e-17
Identities = 57/176 (32%), Positives = 84/176 (47%), Gaps = 1/176 (0%)
Query: 140 LDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHAHLERGRIEAVA 198
LD++ + +PE P L EL N + P AL GL L L+ +++ V
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 199 SSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRT 258
S +++GL L+SL L AN + +V +F L HL L+DN L E+P L L+
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181
Query: 259 LNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 314
L L N + + F +L+ L +L+L N I + + F L L L LN N L
Sbjct: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237
Score = 84.3 bits (207), Expect = 2e-16
Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 2/185 (1%)
Query: 138 RRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAV 197
RR+D + L +VPE L A AL + +N+ + A + L L + +
Sbjct: 39 RRVDCSGKGLTAVPEGLSAFTQALD--ISMNNITQLPEDAFKNFPFLEELQLAGNDLSFI 96
Query: 198 ASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLR 257
+L GL+ L+ L+LQ N+++ V + A L+ L L+ N + +P D+F GL +LR
Sbjct: 97 HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLR 156
Query: 258 TLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVL 317
L L N+L V ++L L+ L L N I+ + + AF NLS L+ LHL+ N++ L
Sbjct: 157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSL 216
Query: 318 AWVAF 322
+ F
Sbjct: 217 SQHCF 221
Score = 81.3 bits (199), Expect = 2e-15
Identities = 78/271 (28%), Positives = 113/271 (41%), Gaps = 28/271 (10%)
Query: 69 LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128
LD N L + LP+L+ L+L N +S I AF L L L L HN +R L
Sbjct: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL-HNNKIRSLSQ 218
Query: 129 RTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHA 187
F L L LDL L P+ + A LP+L+EL N +P GA G L
Sbjct: 219 HCFDGLDNLETLDLNYNNLGEFPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTI 277
Query: 188 HLERGRIEAVASSS-----------------------LQGLRRLRSLSLQANRVRAVHAG 224
HL + V +S+ L G L SL+L ++ ++
Sbjct: 278 HLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNN 337
Query: 225 AFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLY 284
+ +L L L+ N + +LP+ F G L ++L N + ++ F L L +L
Sbjct: 338 LCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILD 395
Query: 285 LDRNSIAFVEEGAFQNLSGLLALHLNGNRLT 315
L RN I + AF L + L ++ N LT
Sbjct: 396 LSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/245 (29%), Positives = 105/245 (42%), Gaps = 33/245 (13%)
Query: 66 SIDLDRNGLRFLGE--RAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNG-- 121
++DL+ N L GE +A LPSL+ L N++S I GAF G P L + L N
Sbjct: 229 TLDLNYNNL---GEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLS 285
Query: 122 --------DLRYLHARTFAALS------------RLRRLDLAACRLFSVPERLLAELPAL 161
+L LH+ S L L L ++ S+P L E L
Sbjct: 286 FVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKML 345
Query: 162 RELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAV 221
R L N R +P + G L L+R +I + + QGL LR L L N + +
Sbjct: 346 RTLDLSYNNIRDLP-SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI 404
Query: 222 HAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGN--ALDRVARAWFADLAE 279
H+ AF G + +L ++ N L P + GL +L+ L GN + +A F +L
Sbjct: 405 HSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK---LVGNFKLKEALAAKDFVNLRS 461
Query: 280 LELLY 284
L + Y
Sbjct: 462 LSVPY 466
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/97 (32%), Positives = 48/97 (49%)
Query: 240 NLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 299
N + +LP DAF+ L L L GN L + + L EL++L L N + V A +
Sbjct: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
Query: 300 NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
LS L +L L+ N +T + +F+ L L+L N
Sbjct: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDN 163
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 116 bits (291), Expect = 4e-26
Identities = 98/274 (35%), Positives = 123/274 (44%), Gaps = 20/274 (7%)
Query: 7 LVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVS 66
L+L+L A+ L PS CP C C + +V C VP LP
Sbjct: 17 LLLMLLALPLAAPS----------CPMLCTCYSSPP--TVSCQANNFSSVPLSLPPSTQR 64
Query: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
+ L N +R L FG+ +L L L NNLS I PG F+ L L EL L N LR L
Sbjct: 65 LFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDN-LFRRVPGALRGLANLT 185
TF L RL+ L L C+L S+P + L +L+ L +N L LANL+
Sbjct: 123 EPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLS 182
Query: 186 HAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAEL 245
H L R+ + +GL L L L NR++ VH AF L L L +N LA L
Sbjct: 183 HLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASL 242
Query: 246 PADAFRGLRRLRTLNLGGN--ALDRVAR---AWF 274
P +A L L L L N A D AR AWF
Sbjct: 243 PGEALADLPSLEFLRLNANPWACDCRARPLWAWF 276
Score = 36.6 bits (83), Expect = 0.052
Identities = 42/120 (35%), Positives = 47/120 (39%), Gaps = 26/120 (21%)
Query: 69 LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128
L N LR L E F L SL RL L N L + AF+GL RL L L +N L L
Sbjct: 186 LHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNS-LASLPG 244
Query: 129 RTFAALSRLRRLDLAA------CRLFSV-------------------PERLLAELPALRE 163
A L L L L A CR + PER +L ALRE
Sbjct: 245 EALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALRE 304
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 116 bits (290), Expect = 5e-26
Identities = 121/475 (25%), Positives = 176/475 (37%), Gaps = 108/475 (22%)
Query: 4 RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCE 63
R +LLL ++L L A C AAC C+ G S+ C GL +P +LP
Sbjct: 14 RSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCA----GDSLDCGGRGLAALPGDLPSW 69
Query: 64 AVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDL 123
S++L N L + F LP+L+ + L +N L+ + P + L L HN +
Sbjct: 70 TRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHN-KI 127
Query: 124 RYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALREL------------AAFDNLF 171
R + A L LDL+ + V P ++EL AFD L
Sbjct: 128 RSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
Query: 172 R-------------RVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRV 218
R ++P L LT L R RI + + QGL L L LQ N +
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 219 RAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVAR-AW---- 273
+ GAF + L L N L E+ + + GL L L+L N++ R+ R W
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
Query: 274 -------------------FADLAELELLYLDRNSIAFVEEGAFQ--------------- 299
A+L+ L +L L NSI+ + EGAF+
Sbjct: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
Query: 300 ------------------------------------NLSGLLALHLNGNRLTVLAWVAFQ 323
L GL L+L GN + + + AF
Sbjct: 368 SGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFV 427
Query: 324 PGFFLGRLFLFRNPWCCDCRLEWLRDWMEGS--GRVTDVPCASPGSVAGLDLSQV 376
L L + + + CDC+L+WL W+ G CA P S+ G + V
Sbjct: 428 KMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSV 482
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 115 bits (287), Expect = 1e-25
Identities = 101/346 (29%), Positives = 157/346 (45%), Gaps = 39/346 (11%)
Query: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
+DL N ++ + +AF L+ L L N +S I GAF+ L L L L +N ++ +
Sbjct: 138 LDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTL-NNNNITTI 196
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV--PGALRGL--A 182
+F + +LR L + LF + LA L LF + P +LRGL A
Sbjct: 197 PVSSFNHMPKLRTFRLHSNHLFC--DCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVA 254
Query: 183 NLTHAHL------ERGRIEAVASSSL-----------------QGL--------RRLRSL 211
+ + E GR+ SS +GL + +
Sbjct: 255 EVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEI 314
Query: 212 SLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVAR 271
L+ N ++++ GAF L + L++N +AE+ DAF+GLR L +L L GN + + R
Sbjct: 315 RLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPR 374
Query: 272 AWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRL 331
F L L+LL L+ N I + AFQ+L L L L N++ LA F + L
Sbjct: 375 GVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTL 434
Query: 332 FLFRNPWCCDCRLEWLRDWMEGSG-RVTDVPCASPGSVAGLDLSQV 376
L +NP+ CDC L+WL D++ + + CASP +A + Q+
Sbjct: 435 HLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480
Score = 112 bits (280), Expect = 7e-25
Identities = 69/195 (35%), Positives = 97/195 (49%), Gaps = 1/195 (0%)
Query: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
N L I + + GL++LR L L N++ AV GAF D LE L LN N L
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLS 302
LP F+ + L L+L NA+ + R F +L+ L LD+N I+ +EEGAF+ L
Sbjct: 122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALR 181
Query: 303 GLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRV-TDVP 361
GL L LN N +T + +F L L N CDC L WL W+ +
Sbjct: 182 GLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQ 241
Query: 362 CASPGSVAGLDLSQV 376
C+ P S+ GL++++V
Sbjct: 242 CSGPASLRGLNVAEV 256
Score = 85.5 bits (210), Expect = 1e-16
Identities = 100/379 (26%), Positives = 157/379 (41%), Gaps = 27/379 (7%)
Query: 69 LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128
L+ N + + AF L +L LSL N + + G F L + L LA N + +
Sbjct: 388 LNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNL 447
Query: 129 RTFAALSRLRRLDLAACRLFSVPERL----LAELPALR-ELAAFDNLFRRVPGA----LR 179
+ A R ++ + R S P RL + ++ + + +A + F +PG L
Sbjct: 448 KWLADFLRTNPIETSGARCAS-PRRLANKRIGQIKSKKFRCSAKEQYF--IPGTEDYQLN 504
Query: 180 GLANLTHAHLERGRIEA--VASSSLQGLR-------RLRSLSLQANRVRAVHA-GAFGDC 229
N + R EA V SSL+ + L L N + + A G F
Sbjct: 505 SECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKL 564
Query: 230 GVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNS 289
L+ + L++N ++E+ AF G + L+L N L+ + F L L L L N
Sbjct: 565 THLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNR 624
Query: 290 IAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRD 349
I+ + +F L + L L N++T ++ AF L L L NP+ C+C+L WL
Sbjct: 625 ISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGG 684
Query: 350 WMEGSGRVTDVP-CASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAA- 407
W+ VT P C +P + + L V F D C + +E P E A
Sbjct: 685 WLRKRKIVTGNPRCQNPDFLRQIPLQDVAF---PDFRCEEGQEEGGCLPRPQCPQECACL 741
Query: 408 TTVSRFSSLLSKLLAPRVP 426
TV R S+ + L +P
Sbjct: 742 DTVVRCSNKHLRALPKGIP 760
Score = 82.4 bits (202), Expect = 8e-16
Identities = 60/224 (26%), Positives = 93/224 (41%), Gaps = 32/224 (14%)
Query: 20 SAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGE 79
+AW +GA A CPA C C+ G +V C GL +P +P ++L+ N + + +
Sbjct: 25 AAWRLGASA--CPALCTCT----GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHK 78
Query: 80 RAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRR 139
F L LR L L N + + GAF + L LRL N
Sbjct: 79 NDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRN------------------- 119
Query: 140 LDLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHAHLERGRIEAVA 198
+L +PE L AL L +N + +P A RG +L + L++ +I +
Sbjct: 120 ------QLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIE 173
Query: 199 SSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
+ + LR L L+L N + + +F L L+ N L
Sbjct: 174 EGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Score = 76.6 bits (187), Expect = 5e-14
Identities = 90/397 (22%), Positives = 148/397 (37%), Gaps = 65/397 (16%)
Query: 31 CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERA-FGTLPSLR 89
CP C C V C L ++P +P + L+ N + L F L L+
Sbjct: 513 CPHKCRCEANV----VECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
Query: 90 RLSLRHNNLSFITPGAFKGLPRLAELRLA-----------------------HNGDLRYL 126
+++L +N +S I GAF+G ++EL L N + +
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLF--------------- 171
H +F L +R L L ++ +V L +L L N F
Sbjct: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688
Query: 172 RRV---------PGALRGLANLTHA----HLERGRIEAVASSSLQGLRRLRSLSLQAN-- 216
R++ P LR + A E G+ E Q + L
Sbjct: 689 RKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCS 748
Query: 217 --RVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWF 274
+RA+ G + + L L+ N +P + L+ ++L N + ++ + F
Sbjct: 749 NKHLRALPKGIPKN---VTELYLDGNQFTLVPGQ-LSTFKYLQLVDLSNNKISSLSNSSF 804
Query: 275 ADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLF 334
++++L L L N++ + AFQ L L L L+GN ++ L F L L +
Sbjct: 805 TNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIG 864
Query: 335 RNPWCCDCRLEWLRDWMEGSGRVTDVP-CASPGSVAG 370
NP CDC L WL W++ + + CA P + G
Sbjct: 865 ANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEG 901
Score = 67.4 bits (163), Expect = 3e-11
Identities = 56/187 (29%), Positives = 82/187 (43%), Gaps = 28/187 (14%)
Query: 30 ACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLR 89
+CPA C CS V C GL +PA LP I L+ NG++ + AF LR
Sbjct: 281 SCPAMCTCSNG----IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLR 336
Query: 90 RLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFS 149
R+ L +N ++ I P AF+GL L L L + + L F L L+ L L A ++
Sbjct: 337 RIDLSNNQIAEIAPDAFQGLRSLNSLVL-YGNKITDLPRGVFGGLYTLQLLLLNANKI-- 393
Query: 150 VPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLR 209
N R P A + L NL+ L +I+++A + LR ++
Sbjct: 394 -------------------NCIR--PDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ 432
Query: 210 SLSLQAN 216
+L L N
Sbjct: 433 TLHLAQN 439
Score = 52.8 bits (125), Expect = 7e-07
Identities = 33/83 (39%), Positives = 43/83 (51%)
Query: 254 RRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNR 313
R L L GN + R+ + FA L +L +L L N I VE GAF ++ L L LN N+
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 314 LTVLAWVAFQPGFFLGRLFLFRN 336
L +L + FQ L RL L N
Sbjct: 121 LHMLPELLFQNNQALSRLDLSEN 143
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 114 bits (285), Expect = 2e-25
Identities = 105/403 (26%), Positives = 171/403 (42%), Gaps = 37/403 (9%)
Query: 1 MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL 60
+KG ++++LL ++L + + RACP C C G V C+ +P +
Sbjct: 9 LKGMSVVLVLLPTLLLVM-----LTGAQRACPKNCRCD----GKIVYCESHAFADIPENI 59
Query: 61 PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 120
+ + L N ++ L F L L L L HN +S + AF+G+ RL EL L+ N
Sbjct: 60 SGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSN 119
Query: 121 GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG 180
+ YLH +TF + LR LDL+ +L ++ +G
Sbjct: 120 -KITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE-----------------------QFKG 155
Query: 181 LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240
L L HL ++ V Q R L L L NR+R++ AF L+ L L N
Sbjct: 156 LRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN 215
Query: 241 LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQN 300
+++ F L LR++ L N + +++ + L L L N I +E G F+
Sbjct: 216 QFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKC 275
Query: 301 LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG--SGRVT 358
L L L+L+ N+LT ++ L + L N W C + L W++ + +
Sbjct: 276 LPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKES 335
Query: 359 DVPCASPGSVAGLDLSQV--TFGRSSDGLCVDPEELNLTTSSP 399
+ CA P + G +S T+ S+ V+ E +L +P
Sbjct: 336 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTP 378
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 114 bits (285), Expect = 2e-25
Identities = 105/403 (26%), Positives = 171/403 (42%), Gaps = 37/403 (9%)
Query: 1 MKGRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL 60
+KG ++++LL ++L + + RACP C C G V C+ +P +
Sbjct: 9 LKGMSVVLVLLPTLLLVM-----LTGAQRACPKNCRCD----GKIVYCESHAFADIPENI 59
Query: 61 PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 120
+ + L N ++ L F L L L L HN +S + AF+G+ RL EL L+ N
Sbjct: 60 SGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSN 119
Query: 121 GDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG 180
+ YLH +TF + LR LDL+ +L ++ +G
Sbjct: 120 -KITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE-----------------------QFKG 155
Query: 181 LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240
L L HL ++ V Q R L L L NR+R++ AF L+ L L N
Sbjct: 156 LRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN 215
Query: 241 LLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQN 300
+++ F L LR++ L N + +++ + L L L N I +E G F+
Sbjct: 216 QFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKC 275
Query: 301 LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG--SGRVT 358
L L L+L+ N+LT ++ L + L N W C + L W++ + +
Sbjct: 276 LPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKES 335
Query: 359 DVPCASPGSVAGLDLSQV--TFGRSSDGLCVDPEELNLTTSSP 399
+ CA P + G +S T+ S+ V+ E +L +P
Sbjct: 336 TMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTP 378
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 112 bits (279), Expect = 1e-24
Identities = 106/376 (28%), Positives = 150/376 (39%), Gaps = 61/376 (16%)
Query: 28 ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPS 87
A +CP AC+CS + V C R L VPA +P ++L NG++ + F L
Sbjct: 54 ATSCPVACSCSN--QASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111
Query: 88 LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRL 147
L L L N + I GAF GLP L L L N L + + F LS+LR L L +
Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDN-RLTTVPTQAFEYLSKLRELWLRNNPI 170
Query: 148 FSVPERLLAELPALR--ELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGL 205
S+P +P+LR +L L A GL NL + +L ++ + +L L
Sbjct: 171 ESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDI--PNLTAL 228
Query: 206 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNA 265
RL L L NR+ + G+F L L L +A + +AF L+ L LNL N
Sbjct: 229 VRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNN 288
Query: 266 LDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPG 325
L + F L LE +HLN
Sbjct: 289 LMSLPHDLFTPLHRLE------------------------RVHLN--------------- 309
Query: 326 FFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAGL------DLSQVTFG 379
NPW C+C + WL W++ + CA + AGL +L Q F
Sbjct: 310 ---------HNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFT 360
Query: 380 RSSDGLCVDPEELNLT 395
+ + P +LN+T
Sbjct: 361 CYAPVIVEPPTDLNVT 376
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 112 bits (279), Expect = 1e-24
Identities = 107/394 (27%), Positives = 161/394 (40%), Gaps = 59/394 (14%)
Query: 28 ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPS 87
A+ CP+ C+CS + V C R L VP G +
Sbjct: 44 AQTCPSVCSCSN--QFSKVICVRKNLREVPD------------------------GISTN 77
Query: 88 LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRL 147
R L+L N + I +FK L L L+L+ N +R + F L+ L L+L RL
Sbjct: 78 TRLLNLHENQIQIIKVNSFKHLRHLEILQLSRN-HIRTIEIGAFNGLANLNTLELFDNRL 136
Query: 148 FSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRR 207
++P L L+EL L IE++ S + +
Sbjct: 137 TTIPNGAFVYLSKLKEL-----------------------WLRNNPIESIPSYAFNRIPS 173
Query: 208 LRSLSL-QANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNAL 266
LR L L + R+ + GAF L +L L L E+P L +L L+L GN L
Sbjct: 174 LRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHL 231
Query: 267 DRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGF 326
+ F L L+ L++ ++ I +E AF NL L+ ++L N LT+L F P
Sbjct: 232 SAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLH 291
Query: 327 FLGRLFLFRNPWCCDCRLEWLRDW---MEGSGRVTDVPCASPGSVAGL---DLSQVTFGR 380
L R+ L NPW C+C + WL W M S C +P ++ G +L Q F
Sbjct: 292 HLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351
Query: 381 SSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFS 414
+ + P +LN+T A+T+++ S
Sbjct: 352 YAPVIVEPPADLNVTEGMAAELKCRASTSLTSVS 385
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 111 bits (277), Expect = 2e-24
Identities = 94/323 (29%), Positives = 155/323 (47%), Gaps = 17/323 (5%)
Query: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
++ LD N + + + AF L L L+L +NN+S I +F +P++ LRL N
Sbjct: 161 NLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCD 220
Query: 126 LHARTFAALSRLRR------LDLAACRL--FSVPERLLAEL--PALRELAAFDNLFR-RV 174
H + R RR L +A L F+V + E PA N
Sbjct: 221 CHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISC 280
Query: 175 PGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEH 234
P N+ +G +E A+ +G+ +R L+ N ++A+ AGAF L+
Sbjct: 281 PSPCTCSNNIVDCR-GKGLMEIPANLP-EGIVEIR---LEQNSIKAIPAGAFTQYKKLKR 335
Query: 235 LLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVE 294
+ ++ N ++++ DAF+GL+ L +L L GN + +A+ F L L+LL L+ N I +
Sbjct: 336 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLR 395
Query: 295 EGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGS 354
FQ+L L L L N+L ++ F P + L L +NP+ CDC L+WL D+++ +
Sbjct: 396 VNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN 455
Query: 355 G-RVTDVPCASPGSVAGLDLSQV 376
+ C+SP +A +SQ+
Sbjct: 456 PIETSGARCSSPRRLANKRISQI 478
Score = 104 bits (259), Expect = 2e-22
Identities = 75/247 (30%), Positives = 111/247 (44%), Gaps = 2/247 (0%)
Query: 132 AALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLA-NLTHAHLE 190
AA+ L LA + S P + A+ D + RG+ N L+
Sbjct: 10 AAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLD 69
Query: 191 RGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAF 250
R I + GL+ LR L L+ N+V + GAF D LE L LN N L LP F
Sbjct: 70 RNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLF 129
Query: 251 RGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLN 310
+ +L L+L N + + R F + +++ L LD N I+ +E+GAF+ L L L LN
Sbjct: 130 QSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLN 189
Query: 311 GNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVP-CASPGSVA 369
N ++ + +F + L L N CDC L WL DW+ V C +P +
Sbjct: 190 NNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLR 249
Query: 370 GLDLSQV 376
G +++ V
Sbjct: 250 GFNVADV 256
Score = 98.2 bits (243), Expect = 1e-20
Identities = 121/474 (25%), Positives = 175/474 (36%), Gaps = 100/474 (21%)
Query: 30 ACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLR 89
+CP+ C CS V C GL+ +PA LP V I L++N ++ + AF L+
Sbjct: 279 SCPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334
Query: 90 RLSLRHNNLSFITPGAFKGLPRLAELRLAHN-----------------------GDLRYL 126
R+ + N +S I P AF+GL L L L N + L
Sbjct: 335 RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL 394
Query: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
TF L L L L +L ++ + L A L +++ L N F L+ LA+
Sbjct: 395 RVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPF-VCDCHLKWLAD--- 450
Query: 187 AHLERGRIEAVAS--SSLQGLRRLRSLSLQANRVRAVHA--------------------- 223
+L+ IE + SS + L R +++ + R +
Sbjct: 451 -YLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKC 509
Query: 224 ---GAFGDCG-------------VLEHLLLNDNLLAELPADA-FRGLRRLRTLNLG---- 262
G DC + L LNDN ++ L A F+ L LR +NL
Sbjct: 510 RCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKI 569
Query: 263 --------------------GNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLS 302
GN L+ V F L+ L+ L L N I V F LS
Sbjct: 570 KEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLS 629
Query: 303 GLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVP- 361
+ L L NR+T + AF L + L NP+ C+C L WL W+ V+ P
Sbjct: 630 SVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR 689
Query: 362 CASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSS 415
C P + + + V D C EE + S P TV R S+
Sbjct: 690 CQKPFFLKEIPIQDVAI---QDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSN 740
Score = 97.8 bits (242), Expect = 2e-20
Identities = 117/422 (27%), Positives = 171/422 (40%), Gaps = 71/422 (16%)
Query: 31 CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERA-FGTLPSLR 89
CP C C G V C L+R+P+ LP + L+ N + L F LP+LR
Sbjct: 505 CPEKCRCE----GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560
Query: 90 RLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFS 149
+++L +N + + GAF G + EL L N L +H R F LS L+ L L + +
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGN-QLETVHGRVFRGLSGLKTLMLRSNLIGC 619
Query: 150 VPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHAHLERGRIEAVASSSLQG--LR 206
V A L ++R L+ +DN + PGA L +L+ +L + G LR
Sbjct: 620 VSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLR 679
Query: 207 RLRSLS----------LQANRVRAVHAGAF-----------------GDCGVLEHLLLND 239
+ R +S L+ ++ V F C +E ++
Sbjct: 680 KRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCS 739
Query: 240 NL-LAELPADAFRGL-RRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGA 297
N L LP RG+ + + L L GN L V R A L L L+ L NSI+ +
Sbjct: 740 NKGLRALP----RGMPKDVTELYLEGNHLTAVPRELSA-LRHLTLIDLSNNSISMLTNYT 794
Query: 298 FQNLSGLLALHLNGNRLTVLAWVAFQ-------------------PGFF-----LGRLFL 333
F N+S L L L+ NRL + AF G F L L L
Sbjct: 795 FSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLAL 854
Query: 334 FRNPWCCDCRLEWLRDWMEGSGRVTDVP-CASPGSVAGLDLSQVTFGRSSDGLCVDPEEL 392
NP CDC L WL +W++ + + C+SP +A L R C P ++
Sbjct: 855 GTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQ---CKGPVDI 911
Query: 393 NL 394
N+
Sbjct: 912 NI 913
Score = 93.2 bits (230), Expect = 5e-19
Identities = 98/365 (26%), Positives = 152/365 (41%), Gaps = 37/365 (10%)
Query: 3 GRGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPC 62
G G V A+ L L S + G A ACP C CS SV C GL VP +P
Sbjct: 7 GVGAAVRARLALALALASVLS-GPPAVACPTKCTCSAA----SVDCHGLGLRAVPRGIPR 61
Query: 63 EAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGD 122
A +DLDRN + + + F L +LR L L N +S I GAF+ L +L LRL N
Sbjct: 62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKN-K 120
Query: 123 LRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGL 181
L+ L F + +L RLDL+ ++ +P + + ++ L +N + GA R L
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
Query: 182 ANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANR------------------------ 217
+L L I + +S + ++R+L L +N
Sbjct: 181 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 240
Query: 218 --VRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWF- 274
+ VH F V + + +E P+ + N +D +
Sbjct: 241 LCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLME 300
Query: 275 --ADLAE-LELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRL 331
A+L E + + L++NSI + GAF L + ++ N+++ +A AFQ L L
Sbjct: 301 IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL 360
Query: 332 FLFRN 336
L+ N
Sbjct: 361 VLYGN 365
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 110 bits (276), Expect = 2e-24
Identities = 113/422 (26%), Positives = 167/422 (39%), Gaps = 53/422 (12%)
Query: 11 LHAVVLGLPSAWAVGACARA--------CPAACAC---------STVERGCSVRCDRAGL 53
+ +V L AW GA A CP CAC S+ +V C+ L
Sbjct: 1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
Query: 54 LRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLA 113
VP LP ++ L N + + + G L +L L L N+ S F LP+L
Sbjct: 61 TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
Query: 114 ELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRR 173
L L N L L +FA L+ L+ L L +L+ + R + L L L NL R
Sbjct: 121 SLHLEEN-QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179
Query: 174 VPGA-LRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVL 232
+ L NL + +++A+ + + L LRSL L +R + A L
Sbjct: 180 IDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSL 239
Query: 233 EHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL---------ELL 283
E L DN LA +P A + L+ L+L N L RV FA++ L EL+
Sbjct: 240 ESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELV 299
Query: 284 YLDRNS-----------------IAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGF 326
+D+ + ++F+ AF +L + L LN N L+ L +
Sbjct: 300 SIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLP 359
Query: 327 FLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVP-----CASPGSVAGLDLSQVTFGRS 381
L + L NP CDC + W RV + CA P + L + +V F
Sbjct: 360 NLQEVGLHGNPIRCDCVIRWAN---ATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREM 416
Query: 382 SD 383
+D
Sbjct: 417 TD 418
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 110 bits (276), Expect = 2e-24
Identities = 113/422 (26%), Positives = 167/422 (39%), Gaps = 53/422 (12%)
Query: 11 LHAVVLGLPSAWAVGACARA--------CPAACAC---------STVERGCSVRCDRAGL 53
+ +V L AW GA A CP CAC S+ +V C+ L
Sbjct: 1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL 60
Query: 54 LRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLA 113
VP LP ++ L N + + + G L +L L L N+ S F LP+L
Sbjct: 61 TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL 120
Query: 114 ELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRR 173
L L N L L +FA L+ L+ L L +L+ + R + L L L NL R
Sbjct: 121 SLHLEEN-QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179
Query: 174 VPGA-LRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVL 232
+ L NL + +++A+ + + L LRSL L +R + A L
Sbjct: 180 IDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSL 239
Query: 233 EHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL---------ELL 283
E L DN LA +P A + L+ L+L N L RV FA++ L EL+
Sbjct: 240 ESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELV 299
Query: 284 YLDRNS-----------------IAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGF 326
+D+ + ++F+ AF +L + L LN N L+ L +
Sbjct: 300 SIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLP 359
Query: 327 FLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVP-----CASPGSVAGLDLSQVTFGRS 381
L + L NP CDC + W RV + CA P + L + +V F
Sbjct: 360 NLQEVGLHGNPIRCDCVIRWAN---ATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREM 416
Query: 382 SD 383
+D
Sbjct: 417 TD 418
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 109 bits (273), Expect = 5e-24
Identities = 99/283 (34%), Positives = 119/283 (42%), Gaps = 3/283 (1%)
Query: 30 ACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLR 89
ACPA C C S C GL VP +L +DL N L L F L L
Sbjct: 34 ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLE 93
Query: 90 RLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFS 149
L L N+LS I AF GL L L L N L + A L L+ L L A +
Sbjct: 94 ELRLSGNHLSHIPGQAFSGLYSLKILML-QNNQLGGIPAEALWELPSLQSLRLDANLISL 152
Query: 150 VPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHAHLERGRIEAVASSSLQGLRRL 208
VPER L +LR L DN +P AL L L L RI + + Q L L
Sbjct: 153 VPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSL 212
Query: 209 RSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDR 268
L L NR++ + +F LE L LN N L E P A R L RL+ L N +
Sbjct: 213 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKA 271
Query: 269 VARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNG 311
+ F L+ ++ N I FV AFQ L L L LNG
Sbjct: 272 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Score = 84.0 bits (206), Expect = 3e-16
Identities = 92/303 (30%), Positives = 132/303 (43%), Gaps = 37/303 (12%)
Query: 45 SVRCDRAGLLRVPAELPCEAVS----IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSF 100
S+R D A L+ + E E +S + LD N L + RA LP+L+ ++L N +S
Sbjct: 142 SLRLD-ANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 200
Query: 101 ITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPA 160
I AF+ L L L L HN +++L +F L L LDL +L P + L
Sbjct: 201 IPDYAFQNLTSLVVLHL-HNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRT-LGR 258
Query: 161 LRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVR 219
L+EL +N + +P A G L H I+ V S+ Q L +L +LSL
Sbjct: 259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG---- 314
Query: 220 AVHAGAFGDCG---VLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA------ 270
A+ F D LE L L + LP+ + L RLR L L N ++ +
Sbjct: 315 AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ 374
Query: 271 ----------RAW------FADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 314
R W F+ L+ L+ L L N+I + AF L L+ L L N+L
Sbjct: 375 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
Query: 315 TVL 317
T L
Sbjct: 435 TTL 437
Score = 78.6 bits (192), Expect = 1e-14
Identities = 56/176 (31%), Positives = 82/176 (46%), Gaps = 1/176 (0%)
Query: 140 LDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVA 198
LDL+ L + L L L EL N +PG A GL +L L+ ++ +
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 199 SSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRT 258
+ +L L L+SL L AN + V +F L HL L+DN L E+P A L L+
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
Query: 259 LNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 314
+ L N + + F +L L +L+L N I + +F+ L L L LN N+L
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
Score = 77.8 bits (190), Expect = 2e-14
Identities = 50/158 (31%), Positives = 79/158 (50%)
Query: 166 AFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGA 225
+ +NL PG L L L + + + GL L+ L LQ N++ + A A
Sbjct: 74 SMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA 133
Query: 226 FGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYL 285
+ L+ L L+ NL++ +P +F GL LR L L NAL + +L L+ + L
Sbjct: 134 LWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTL 193
Query: 286 DRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQ 323
N I+ + + AFQNL+ L+ LHL+ NR+ L +F+
Sbjct: 194 ALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 231
Score = 70.5 bits (171), Expect = 3e-12
Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 8/215 (3%)
Query: 72 NGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTF 131
N ++ + E+AF P L+ + N + F+ AF+ LP+L L L NG +
Sbjct: 267 NNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDL 324
Query: 132 AALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLER 191
+ L L L + +P + +LP LR L N +P +L L L+
Sbjct: 325 KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQH 383
Query: 192 GRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFR 251
RI + + + L L++L L N +R++H AF L L L DN L LP
Sbjct: 384 NRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LA 440
Query: 252 GLRRLRTLNLGGN-ALDRV-ARAWFADLAELELLY 284
GL L L L GN AL + ++ F L LE+ Y
Sbjct: 441 GLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPY 475
Score = 60.5 bits (145), Expect = 3e-09
Identities = 39/105 (37%), Positives = 52/105 (49%)
Query: 211 LSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA 270
L L N + + G F LE L L+ N L+ +P AF GL L+ L L N L +
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 271 RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLT 315
+L L+ L LD N I+ V E +F+ LS L L L+ N LT
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT 175
Score = 31.6 bits (70), Expect = 1.7
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 5/77 (6%)
Query: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
++DL N +R + AF TL SL +L L N L+ + GL + L G+L
Sbjct: 402 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGL-----MHLKLKGNLAL 456
Query: 126 LHARTFAALSRLRRLDL 142
A + + +LR L++
Sbjct: 457 SQAFSKDSFPKLRILEV 473
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 108 bits (270), Expect = 1e-23
Identities = 111/371 (29%), Positives = 160/371 (43%), Gaps = 56/371 (15%)
Query: 16 LGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLR 75
LG PS A R CP C C G + C R L R+P LP +DL N L
Sbjct: 35 LGQPSGVAA---ERPCPTTCRCL----GDLLDCSRKRLARLPEPLPSWVARLDLSHNRLS 87
Query: 76 FLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL--HARTFAA 133
F+ + L SLR + L +N L I P + L LA N + L H + F +
Sbjct: 88 FIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQS 146
Query: 134 LSRLRRLDLAACRLFSVPERLLAELPALR--------------ELAAFDNL--------- 170
L L DL++ + L PAL+ E FDNL
Sbjct: 147 LETL---DLSSNNI----SELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKL 199
Query: 171 ----FRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAF 226
+P + L L H L R +I+ V + QGL L+SL +Q N V + GAF
Sbjct: 200 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 259
Query: 227 GDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA-RAW--FADLAELELL 283
+E L L+ N L E+ GL L+ L+L NA++R++ AW L+EL+L
Sbjct: 260 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 319
Query: 284 YLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCR 343
+ N ++ +++ +F LS L LH+ NR++ +A AF+ L L L N
Sbjct: 320 F---NHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN------E 370
Query: 344 LEWLRDWMEGS 354
+ W + M G+
Sbjct: 371 ISWTIEDMNGA 381
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/205 (32%), Positives = 101/205 (49%), Gaps = 5/205 (2%)
Query: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
S+ + RNG+ L + AF L ++ L L HNNL+ IT G GL L EL L+ N +
Sbjct: 243 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA-INR 301
Query: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANL 184
+ + +L LDL L + + L L L +N + A RGL++L
Sbjct: 302 ISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSL 361
Query: 185 THAHLERGRIEAVA---SSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNL 241
L+ I + + GL +LR L LQ NR+R++ AF LEHL L+DN
Sbjct: 362 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 421
Query: 242 LAELPADAFRGLRRLRTLNLGGNAL 266
+ L +AF +++L+ L+L ++L
Sbjct: 422 IMSLQGNAFSQMKKLQQLHLNTSSL 446
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 108 bits (269), Expect = 1e-23
Identities = 92/254 (36%), Positives = 116/254 (45%), Gaps = 25/254 (9%)
Query: 143 AACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHAHLERGRIEAVASSS 201
AACR +S E ALR R VP G G L L+ I + +
Sbjct: 25 AACRCYSAT----VECGALR--------LRVVPLGIPPGTQTL---FLQDNNIARLEPGA 69
Query: 202 LQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNL 261
L L LR L L N +RA+ AGAF L L L N L L + AF GL +LR L L
Sbjct: 70 LAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYL 129
Query: 262 GGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVA 321
GN L R+ F L L+ L+L NSI +E+ A LS L L L+ N+L ++ A
Sbjct: 130 AGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREA 189
Query: 322 FQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSG------RVTDVPCASPGSVAGLDLSQ 375
QP L L L NPW CDC L WL W++ G R + CA P +A L
Sbjct: 190 LQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLD 249
Query: 376 VTFGRSSDGLCVDP 389
V+ S +C+ P
Sbjct: 250 VS---HSSLICIPP 260
Score = 87.4 bits (215), Expect = 3e-17
Identities = 66/190 (34%), Positives = 94/190 (49%), Gaps = 6/190 (3%)
Query: 28 ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPS 87
A CPAAC C + +V C L VP +P ++ L N + L A L +
Sbjct: 20 AAGCPAACRCYSA----TVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAA 75
Query: 88 LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRL 147
LRRL L +N+L + GAF+ PRL EL L N LR L + F L++LR L LA +L
Sbjct: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSN-RLRGLRSGAFVGLAQLRVLYLAGNQL 134
Query: 148 FSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGLR 206
+ + LP L+EL +N + AL GL++L L R ++ ++ +LQ L
Sbjct: 135 ARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLA 194
Query: 207 RLRSLSLQAN 216
L+ L L N
Sbjct: 195 SLQVLRLTEN 204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,403,074
Number of Sequences: 37866
Number of extensions: 843726
Number of successful extensions: 6513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 3634
Number of HSP's gapped (non-prelim): 1176
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.