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Search of human proteins with 24497485
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens] 1107 0.0
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens] 659 0.0
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 560 e-159
gi|148664184 solute carrier family 22, member 10 [Homo sapiens] 508 e-144
gi|211059435 solute carrier family 22, member 24 [Homo sapiens] 482 e-136
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 474 e-134
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 473 e-133
gi|153791484 putative UST1-like organic anion transporter [Homo ... 468 e-132
gi|42542386 solute carrier family 22 (organic anion/cation trans... 454 e-128
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 430 e-120
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 419 e-117
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 419 e-117
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 418 e-117
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 314 2e-85
gi|166064021 solute carrier family 22 (organic anion transporter... 310 2e-84
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 309 4e-84
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 248 1e-65
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 241 1e-63
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 234 1e-61
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 224 2e-58
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 223 3e-58
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 216 6e-56
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 192 5e-49
gi|157426885 organic cation transporter like 4 [Homo sapiens] 186 5e-47
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 182 7e-46
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1... 137 3e-32
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6... 131 2e-30
gi|169202895 PREDICTED: similar to solute carrier family 22, mem... 129 9e-30
gi|239750073 PREDICTED: similar to solute carrier family 22, mem... 129 9e-30
gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo ... 129 9e-30
>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
Length = 553
Score = 1107 bits (2862), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
Sbjct: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
Sbjct: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
Sbjct: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH 540
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
Sbjct: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH 540
Query: 541 GTLGNSVLKSTQF 553
GTLGNSVLKSTQF
Sbjct: 541 GTLGNSVLKSTQF 553
>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
Length = 332
Score = 659 bits (1701), Expect = 0.0
Identities = 332/332 (100%), Positives = 332/332 (100%)
Query: 222 MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 281
MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE
Sbjct: 1 MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60
Query: 282 SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 341
SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL
Sbjct: 61 SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120
Query: 342 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 401
RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180
Query: 402 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 461
HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240
Query: 462 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 521
TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 300
Query: 522 PLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF 553
PLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
Sbjct: 301 PLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF 332
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 560 bits (1443), Expect = e-159
Identities = 284/534 (53%), Positives = 372/534 (69%), Gaps = 5/534 (0%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAFS+LL+ GG+G FQ LQ + ++ + + +Q +LENFSAA+P HRCW +LDN +A
Sbjct: 1 MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
++ +++P+ALL ISIPPGPNQ PHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
Sbjct: 61 ST---NMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 117
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VYDRS+FTSTIVAKW+LVC S LKP++QSI+++GILVG+ G S RFGR+ +L+W
Sbjct: 118 VYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCC 177
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ+AV GT+ FAP F +YC RF+ AF +AG+ +++ TL++EWT R + MT+
Sbjct: 178 LQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCA 237
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
FS G +A+ +RDW LQL SVPFF L SWWL ESARWL+ G+ D LQEL
Sbjct: 238 FSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELR 297
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
+VA ING ++ LT EVL+S+++EE++ + P S+ L +P LR+R+C + F+
Sbjct: 298 KVARINGHKEAKN-LTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSL 356
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
+++GL DLQ+LG +IFLLQ G VD + LLLS LGRR A S +AGL I
Sbjct: 357 LISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAI 416
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
LAN LVP ++ LR AVLG G G + TC+TIY +ELFPT +RMTA G+ R GA
Sbjct: 417 LANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGA 476
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAAL-LLPETQSLPLPDTIQDVQNQ 533
++GPL+ + P LP L+YG + + S L L LPETQ LPLPDTIQD+++Q
Sbjct: 477 MMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQ 530
>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
Length = 541
Score = 508 bits (1309), Expect = e-144
Identities = 268/533 (50%), Positives = 341/533 (63%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF ELL VGGLGRFQ+L + ++ S+M L +LENF+AA+P HRCW +LDN+T
Sbjct: 1 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G LS +ALL ISIP N RP +CRRF PQWQLL N T S SEADTEPCVDGW
Sbjct: 61 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VYD+S F STIV KW+LVCD +LK + Q + L G+LVG G SDRFGRR +L W
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ+A+ T AAFAP FPVYC+ RFL F+ ++ N + EW ++ LV+ L+S
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
S G + +AY RDW L +V SVPFF+ FL S WL ESARWL+ T +LD GL+ L
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
+VA NG ++TL EV+ S M+EEL Q ++ L R P +R R CI FA
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
F+G ++LQ +GSNIFLLQ+ G V + + ALL L+H+GRR + + L GL I
Sbjct: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
LANT VP EM LR ALA LG+G A F+ + ++ EL PTVLR A G+ A+R GA
Sbjct: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533
L PL+ L V LP ++YG P++ GL LLPET++LPLPDTI+DV+NQ
Sbjct: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533
>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
Length = 551
Score = 482 bits (1240), Expect = e-136
Identities = 256/555 (46%), Positives = 348/555 (62%), Gaps = 6/555 (1%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M F LLD VGG+GRFQ+ ++ + L +LENF+A PSHRCW PLLDN T
Sbjct: 1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G+LS + LL ISIP N RP +C+RF PQWQLL N T + +E DTEPCVDGW
Sbjct: 61 DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VYDRS F STIV +W+LVC+S +LK M QS+++AG L+G G SDR GR+++ +
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ+A+ T AAFAP F VYC+ RFL F+ ++ NT L +EWT R+R + + +
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
+S G L +A+ ++DW +LQL VS P + FL SW + ESARWL+ +LD GL+EL
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVA INGK ++TLT E++ S M++EL + S+ +L R P LR R + LC+ F
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMR--VFGLCFVRF 358
Query: 361 GFT--FFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGL 418
T F+GL L+LQ LGSN+ L Q+ G V A+ +LL L+H+GRR + GL
Sbjct: 359 AITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGL 418
Query: 419 CILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG 478
IL NT +P EM LR LA LG+G V AA +++ +EL PT+LR T G+ ++ R
Sbjct: 419 FILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRT 478
Query: 479 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKA 538
GA L PL+ L + P LP + YG P+L+ LLLPET+ LPLP+TIQDV+N+ K +
Sbjct: 479 GAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE--KDS 536
Query: 539 THGTLGNSVLKSTQF 553
+ ++ +K TQF
Sbjct: 537 RNIKQEDTCMKVTQF 551
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 474 bits (1220), Expect = e-134
Identities = 245/537 (45%), Positives = 341/537 (63%), Gaps = 11/537 (2%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF++LL VGG+GRFQ +Q +++ ++ + + + L+NF+AA+P+H C P N
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
LS L + +P +P C RF PQW L N T + + A TEPC DGW
Sbjct: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
+YD S F STIV +W+LVC AL+ +AQS+Y+ G+L+GA G +DR GRR VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ AV GT AAFAP FP+YC FR L A+AG+ +N TL +EW R V TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
+S G L A VAY V W LQL+VS PFF F+YSW+ ESARW ++GRLD L+ L
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVA INGK L+ EVL +++++EL+MG+ AS LLR P LR ++ WFA
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
F ++GL +DLQ G +I+L+Q+ G VD+PAK+ L+++ LGRRP A+LLLAG+CI
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
L N ++P + +R++LAVLG G + A+F CI +Y+ EL+PT++R T +G+G AR G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKK 537
I+ PLV + P +PL +YG VPV + +LLPET PLPDT+QD++++ K+
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQ 526
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 473 bits (1218), Expect = e-133
Identities = 244/533 (45%), Positives = 339/533 (63%), Gaps = 11/533 (2%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF++LL VGG+GRFQ +Q +++ ++ + + + L+NF+AA+P+H C P N
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
LS L + +P +P C RF PQW L N T + + A TEPC DGW
Sbjct: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
+YD S F STIV +W+LVC AL+ +AQS+Y+ G+L+GA G +DR GRR VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ AV GT AAFAP FP+YC FR L A+AG+ +N TL +EW R V TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
+S G L A VAY V W LQL+VS PFF F+YSW+ ESARW ++GRLD L+ L
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVA INGK L+ EVL +++++EL+MG+ AS LLR P LR ++ WFA
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
F ++GL +DLQ G +I+L+Q+ G VD+PAK+ L+++ LGRRP A+LLLAG+CI
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
L N ++P + +R++LAVLG G + A+F CI +Y+ EL+PT++R T +G+G AR G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533
I+ PLV + P +PL +YG VPV + +LLPET PLPDT+QD++++
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR 522
>gi|153791484 putative UST1-like organic anion transporter [Homo
sapiens]
Length = 547
Score = 468 bits (1203), Expect = e-132
Identities = 248/535 (46%), Positives = 334/535 (62%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF +LLD VGGLGRFQ+LQ + L++ + + Q+ LENF+A + HRCW +LDN T
Sbjct: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G+LS +ALL ISIP N RP +CRRF PQW+L+ N T + SE DTEPCVDGW
Sbjct: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VYD+S F STIV KW+LVC+S L +A+ +++AG++VG G SDRFGR+ VL WSY
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ+A++GT AAFAP VYC RFL A +++NT L++EW + + +TL
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
S GH ++A+ +RD +LQLV+S P F+ FL+S WLAESARWL+ + + GL+EL
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
+ A NG +D LT EVL S M++EL Q SL LLR+P + R C + FA
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
F+GL L LQ LG+N+FLLQ G V + A A L+H+ RR + + L C+
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
LA VP EM LR LA LG+G TC T +EL P+++R A G+ A G
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAV 535
L L+ +L ++ LP ++YG +LSGL LLLPET++ PL D+IQDV+N+ V
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGV 535
>gi|42542386 solute carrier family 22 (organic anion/cation
transporter), member 9 [Homo sapiens]
Length = 553
Score = 454 bits (1169), Expect = e-128
Identities = 243/534 (45%), Positives = 326/534 (61%), Gaps = 1/534 (0%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF +LL G L RFQ+LQT+ L + + MLENF+A +P HRCW +LDN T
Sbjct: 1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G+LS +ALL ISIP N RP +CRRF PQWQLL N T + S+AD EPCVDGW
Sbjct: 61 DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VYDR F+STIV +W+LVCDS +L +A+ +++AG++VG G SDRFGRR VL W Y
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ+A++GT AA AP F +YC RFL A ++ NT L+ EW R + + +TL
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
A +A+ +RDW +LQLVVSVP+F+ FL S WL ESARWL+ + + GL+EL
Sbjct: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQ-PPASLGTLLRMPGLRFRTCISTLCWFA 359
+ A +G +DTLT E+L S M++EL Q SL +L MP + R + + FA
Sbjct: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
Query: 360 FGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLC 419
+FGL L +Q LG+N+FLLQ G V + A A L ++ RR + + L +C
Sbjct: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
Query: 420 ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGG 479
+LA VP EM LR LA LGLG A T + +E+ PT++R A+G+ A
Sbjct: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
Query: 480 AILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533
L PL+ +L V+ P LP ++YG P +SG A LLLPET++ PL DTIQD +N+
Sbjct: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNE 534
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 430 bits (1105), Expect = e-120
Identities = 223/536 (41%), Positives = 335/536 (62%), Gaps = 23/536 (4%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M FSE+LD VG +G FQ L L + I+ + ++L+ F+AA P H C P N++
Sbjct: 1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPP--HNASTG 58
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+L P GPN +P +C RF P PNA+ + ++ EPC+DGW
Sbjct: 59 PWVL-------------PMGPNGKPERCLRFVHP------PNASLPNDTQRAMEPCLDGW 99
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VY+ + +IV +W+LVC+S+ LK MAQSI++AGIL+G G SDRFGRR +LT SY
Sbjct: 100 VYNST--KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
L +A G+ AAF+P FP+Y +FRFL F ++G+ ++T L +EW R R ++ T
Sbjct: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
++FG + +AY + W LQL VS+PFF+ FL SWW ES RWL+ +G+ L+ L
Sbjct: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVA NGK + L+ E L +++E+S+ + + L R+P LR T +L WFA
Sbjct: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
GF ++ LA+ ++ G N+++LQ+ G VD+PAK +L LS+LGR T AA+LLLAG I
Sbjct: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
LA T VP ++ +R+ LAV G G + ++F+C+ +Y+SEL+PTV+R T +G+ + R G+
Sbjct: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVK 536
++ PLV++ G P++P ++YG +L G AAL LPET + PLP+TI+D++N +++
Sbjct: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLR 513
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 419 bits (1078), Expect = e-117
Identities = 215/533 (40%), Positives = 325/533 (60%), Gaps = 9/533 (1%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF++LLD +G +GRFQ+ T L++ L + L+NF+AAVP H C P +++ A
Sbjct: 1 MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA-NHTEAS 59
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G A L +IP P CRRF +PQW LL PN++ A TE C DGW
Sbjct: 60 TNDSG-----AWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGW 111
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
VY+RS+F STIV +W+LVC++ L+ +AQS+Y+AG+LVGAA G +DR G + L WSY
Sbjct: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ+A G A A+ +F YC+FRFL+ +G+++N+ +L++EW R R + L
Sbjct: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
F+ G + A VAY +R W LQ +S PF + FLYSWWL ES+RWLL G+ +Q L
Sbjct: 232 FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQ 291
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
+VAA+NG+ + LT EV+ S ++ E + S+ L R P +R TC + WF+
Sbjct: 292 KVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSN 351
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
++GLA+DLQ G +++L+Q G+++ PA + A + ++GRR T+A+ L+LAGL +
Sbjct: 352 SVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
+AN VP L +A A LG G + ++F C+ +++ EL+PT +R +G + AR G
Sbjct: 412 IANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533
+ PLV LG + LP + +G +L+GLA +L ET+++PL +TI ++ +
Sbjct: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 419 bits (1077), Expect = e-117
Identities = 228/537 (42%), Positives = 315/537 (58%), Gaps = 55/537 (10%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF++LL VGG+GRFQ +Q +++ ++ + + + L+NF+AA+P+H C P N
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
LS L + +P +P C RF PQW L N T + + A TEPC DGW
Sbjct: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
+YD S F STIV +W+LVC AL+ +AQS+Y+ G+L+GA G +DR GRR VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ AV GT AAFAP FP+YC FR L A+AG+ +N TL +EW R V TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
+S G L A VAY V W LQL+VS PFF F+YSW+ ESARW ++GRLD L+ L
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVA INGK L+ EVL +++++EL+MG+ AS LLR P LR ++ WFA
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
F ++GL +DLQ G +I+L+Q+ G VD+PAK+ L+++ LGRRP A+LLLAG+CI
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
L N ++P + +R++LAVLG G + A+F CI +Y+ EL+PT++R V
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAVTV----------- 458
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKK 537
LLPET PLPDT+QD++++ K+
Sbjct: 459 ---------------------------------LLPETLGQPLPDTVQDLESRKGKQ 482
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 418 bits (1075), Expect = e-117
Identities = 227/533 (42%), Positives = 313/533 (58%), Gaps = 55/533 (10%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
MAF++LL VGG+GRFQ +Q +++ ++ + + + L+NF+AA+P+H C P N
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
LS L + +P +P C RF PQW L N T + + A TEPC DGW
Sbjct: 57 ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
+YD S F STIV +W+LVC AL+ +AQS+Y+ G+L+GA G +DR GRR VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
LQ AV GT AAFAP FP+YC FR L A+AG+ +N TL +EW R V TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
+S G L A VAY V W LQL+VS PFF F+YSW+ ESARW ++GRLD L+ L
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
RVA INGK L+ EVL +++++EL+MG+ AS LLR P LR ++ WFA
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
F ++GL +DLQ G +I+L+Q+ G VD+PAK+ L+++ LGRRP A+LLLAG+CI
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
L N ++P + +R++LAVLG G + A+F CI +Y+ EL+PT++R V
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAVTV----------- 458
Query: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533
LLPET PLPDT+QD++++
Sbjct: 459 ---------------------------------LLPETLGQPLPDTVQDLESR 478
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 314 bits (804), Expect = 2e-85
Identities = 200/544 (36%), Positives = 284/544 (52%), Gaps = 25/544 (4%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M F ELL+ VGG G FQ+ L + + L +L F AAVP+HRC P + A
Sbjct: 1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP---GAPAN 57
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSW--------SEAD 112
S + L +P P+ C RF PQ PN T E
Sbjct: 58 FS-----HQDVWLEAHLPREPDGTLSSCLRFAYPQAL---PNTTLGEERQSRGELEDEPA 109
Query: 113 TEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGR 172
T PC GW YD S F+STI +W+LVC+ L A + + AG+LVGA A G SDRFGR
Sbjct: 110 TVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGR 169
Query: 173 RLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPL 232
R +L +Y+ V+G A+A + ++ ++ + R L A+AG + L +EW R +
Sbjct: 170 RRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTV 229
Query: 233 VMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 292
L+S ++ G L A V Y +RDW L L V++P L WW+ ESARWLLT G +
Sbjct: 230 AGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHV 289
Query: 293 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI 352
+ L A +NG+ +D+ + E + E + +P S L R P LR +
Sbjct: 290 KEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP--SYLDLFRTPRLRHISLC 347
Query: 353 STLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 412
+ WF F+++GL+LD+ LG N++ Q+ G V++P+K+ L + + GRR T A +
Sbjct: 348 CVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGT 407
Query: 413 LLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472
LL L LV +M + + LAV+G AAFT +++SEL+PTVLR T +GL
Sbjct: 408 LLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 467
Query: 473 QMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDV 530
+ R G L PL LL G W LP L YG + +L+ ALLLPET+ LP+TIQDV
Sbjct: 468 ALVGRLGGSLAPLAALL--DGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDV 525
Query: 531 QNQA 534
+ ++
Sbjct: 526 ERKS 529
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 310 bits (795), Expect = 2e-84
Identities = 186/530 (35%), Positives = 283/530 (53%), Gaps = 19/530 (3%)
Query: 3 FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLEN-FSAAVPSHRCWAPLLDNSTAQA 61
F ++L +G GRFQ+ Q + L+ + +L + F H C + N T
Sbjct: 4 FVQVLAEIGDFGRFQI-QLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF-- 60
Query: 62 SILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWV 121
+LS L +S+P P C FR P + + ++E T+PC GW
Sbjct: 61 ----NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWE 114
Query: 122 YDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYL 181
Y + S + ++NLVCD LK QS+++AG+LVG GP DR GR+ + L
Sbjct: 115 YPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLL 173
Query: 182 QMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGF 241
++G A AF P+F +Y RF +A AVAG+ + TLL EW R + L F
Sbjct: 174 LFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNF 233
Query: 242 SFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWR 301
S G + A +AYG R+W LLQ+ + P L F Y W L ESARWLLT GR+D +Q + +
Sbjct: 234 SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQK 293
Query: 302 VAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFG 361
A++N + L+PE++ + E+ P + L R P LR T I WF
Sbjct: 294 AASVNRR-----KLSPELMNQLVPEKTG---PSGNALDLFRHPQLRKVTLIIFCVWFVDS 345
Query: 362 FTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCIL 421
++GL+L + G +++L Q+ G V++PA+ ++ ++ GR+ + +L+L GL +
Sbjct: 346 LGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCI 405
Query: 422 ANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAI 481
+P ++ + + LAV+G AAFT +YS+ELFPT+LR T +GL + +R G I
Sbjct: 406 IIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGI 465
Query: 482 LGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 531
L PLV LLG + LP+L+YG++P+++GL LLPET L DT+QD++
Sbjct: 466 LTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 309 bits (792), Expect = 4e-84
Identities = 200/546 (36%), Positives = 285/546 (52%), Gaps = 27/546 (4%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M F ELL+ VGG G FQ+ L + + L +L F AAVP+HRC P + A
Sbjct: 1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP---GAPAN 57
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSW--------SEAD 112
S + L +P P+ C RF PQ PN T E
Sbjct: 58 FS-----HQDVWLEAHLPREPDGTLSSCLRFAYPQAL---PNTTLGEERQSRGELEDEPA 109
Query: 113 TEPCVDGWVYDRSIFTSTIV--AKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRF 170
T PC GW YD S F+STI ++W+LVC+ L A + + AG+LVGA A G SDRF
Sbjct: 110 TVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRF 169
Query: 171 GRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARAR 230
GRR +L +Y+ V+G A+A + ++ ++ + R L A+AG + L +EW R
Sbjct: 170 GRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHR 229
Query: 231 PLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTG 290
+ L+S ++ G L A V Y +RDW L L V++P L WW+ ESARWLLT G
Sbjct: 230 TVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQG 289
Query: 291 RLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRT 350
+ + L A +NG+ +D+ + E + E + +P S L R P LR +
Sbjct: 290 HVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP--SYLDLFRTPRLRHIS 347
Query: 351 CISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLA 410
+ WF F+++GL+LD+ LG N++ Q+ G V++P+K+ L + + GRR T A
Sbjct: 348 LCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQA 407
Query: 411 ASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVG 470
+LL L LV +M + + LAV+G AAFT +++SEL+PTVLR T +G
Sbjct: 408 GTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMG 467
Query: 471 LGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQ 528
L + R G L PL LL G W LP L YG + +L+ ALLLPET+ LP+TIQ
Sbjct: 468 LTALVGRLGGSLAPLAALL--DGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQ 525
Query: 529 DVQNQA 534
DV+ ++
Sbjct: 526 DVERKS 531
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 248 bits (633), Expect = 1e-65
Identities = 176/573 (30%), Positives = 281/573 (49%), Gaps = 41/573 (7%)
Query: 3 FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQAS 62
+ E+ +G G FQ L L SI+ + F A P HRC P A+
Sbjct: 4 YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP-------DAA 56
Query: 63 ILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQL-----LDPNATATSWSEADTEPCV 117
L S + + + G + PH CRR+R L+P + + E C+
Sbjct: 57 NLSSAWRNHTVPLRLRDG-REVPHSCRRYRLATIANFSALGLEPGRDV-DLGQLEQESCL 114
Query: 118 DGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLT 177
DGW + + ++ STIV +WNLVC+ P+ S++ G+L+G+ G SDRFGR+ VL
Sbjct: 115 DGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVL- 173
Query: 178 WSYLQMAVMGTAAAFAPAFPV-YCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL 236
++ M M T +F F + +F L G + N + T + + +
Sbjct: 174 --FVTMG-MQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230
Query: 237 NSLG----FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 292
++LG ++FG+ + AY +RDW +L + +++P LC W++ ES RWL++ GR
Sbjct: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290
Query: 293 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI 352
+ + + A NG P S +++ S Q ++ LLR +R T +
Sbjct: 291 EEAEVIIRKAAKANGIVVPSTIFDP----SELQDLSSKKQQSHNILDLLRTWNIRMVTIM 346
Query: 353 STLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 412
S + W +FGL+LD L +IF+ +V++PA + A LLL +L RR ++A +
Sbjct: 347 SIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATA 406
Query: 413 LLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472
L L G +L LVP ++ L + L ++G GV AAF+ + +Y++EL+PTV+R VG+
Sbjct: 407 LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVS 466
Query: 473 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQN 532
A+R G+IL P LG + +LP ++ G++ +L+ + L LPE+ PLPDTI Q
Sbjct: 467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID--QM 524
Query: 533 QAVKKATH------------GTLGNSVLKSTQF 553
VK H G ++LKST F
Sbjct: 525 LRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF 557
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 241 bits (616), Expect = 1e-63
Identities = 180/562 (32%), Positives = 277/562 (49%), Gaps = 63/562 (11%)
Query: 2 AFSELLDLVGGLGRFQ----VLQTMA------LMVSIMWLCTQS---MLENFSAAVPSHR 48
+F E L VG GRFQ +L + L V +++L TQ SAA + R
Sbjct: 3 SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
Query: 49 C-WAPLLD-NSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATAT 106
C W+P + N TA AS P P +R +C+R+ + + +A+AT
Sbjct: 63 CGWSPEEEWNRTAPASR--------------GPEPPERRGRCQRYLL---EAANDSASAT 105
Query: 107 SW------------SEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLA 154
S A PC GW Y ++ STIV++++LVC + + + Q+I
Sbjct: 106 SALSCADPLAAFPNRSAPLVPCRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNL 163
Query: 155 GILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVM 214
G L GA G A+DR+GR ++ S L + V G AFAP FPV+ +FRFL G
Sbjct: 164 GFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTW 223
Query: 215 MNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFL 274
M ++ E ++ R +V + + F+ G + +AY + +W +QL +++P FL L
Sbjct: 224 MTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLL 283
Query: 275 YSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP 334
Y W + ES RWL+T + D LQ L R+A NGK LS+ E+++
Sbjct: 284 YYWVVPESPRWLITRKKGDKALQILRRIAKCNGK-----------YLSSNYSEITVTDEE 332
Query: 335 ASLGT---LLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIP 391
S + L+R P +R T I WF + GL + L +G N+++ GVV++P
Sbjct: 333 VSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELP 392
Query: 392 AKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTC 451
+ LL + LGRR AAS ++AG+ L +P + LR+ +A LG G+ AF
Sbjct: 393 GALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEI 452
Query: 452 ITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSG 509
+ + +SEL+PT LR V L G I+ P + L + W LPL+++G + + G
Sbjct: 453 VYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFL-LFRLAAVWLELPLIIFGILASICG 511
Query: 510 LAALLLPETQSLPLPDTIQDVQ 531
+LLPET+ + LP+T+ DV+
Sbjct: 512 GLVMLLPETKGIALPETVDDVE 533
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 234 bits (598), Expect = 1e-61
Identities = 162/539 (30%), Positives = 263/539 (48%), Gaps = 29/539 (5%)
Query: 3 FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQAS 62
+ E++ +G G FQ L L SI+ M F A P HRC P A+
Sbjct: 4 YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP-------DAA 56
Query: 63 ILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQL-----LDPNATATSWSEADTEPCV 117
L S + + + G + PH C R+R L+P + + E C+
Sbjct: 57 NLSSAWRNNSVPLRLRDG-REVPHSCSRYRLATIANFSALGLEPGRDV-DLGQLEQESCL 114
Query: 118 DGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLT 177
DGW + + ++ ST+V +WNLVC+ + P+ S++ G+L+G+ G SDRFGR+ VL
Sbjct: 115 DGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVL- 173
Query: 178 WSYLQMAVMGTAAAFAPAFPV-YCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL 236
+ MAV T +F F + + +F L G + N + T + + +
Sbjct: 174 --FATMAVQ-TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIF 230
Query: 237 NSLG----FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 292
++LG F+ G+ L AY +RDW +L L ++VP LC W++ ES RWL++ R
Sbjct: 231 STLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRF 290
Query: 293 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI 352
+ + A +N + P V+ ++ E + Q A + L R + T +
Sbjct: 291 REAEDIIQKAAKMN------NIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIM 344
Query: 353 STLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 412
S L W +F L+LD L + +L +++IPA + A LLL L RR +AA
Sbjct: 345 SLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAV 404
Query: 413 LLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472
L G +L LVP + L L +LG G+ +AF+ + ++++EL+PT++R AVG+
Sbjct: 405 LFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVT 464
Query: 473 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 531
A+R G+I+ P LG + LP +V G++ VL G+ L PE+ + LP+T++ +Q
Sbjct: 465 STASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 224 bits (570), Expect = 2e-58
Identities = 172/541 (31%), Positives = 254/541 (46%), Gaps = 29/541 (5%)
Query: 5 ELLDLVGGLGRFQ---VLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQA 61
++L+ VG G FQ L L + +C + F+ P H C +P A+
Sbjct: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFT---PDHHCQSP----GVAEL 58
Query: 62 SILGSLSPEALLAISIP---PGPNQRPHQCRRFR----QPQWQLLDPNAT-ATSWSEADT 113
S SP L ++P P QCRR+ Q +DP A+ AT+ S
Sbjct: 59 SQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPL 118
Query: 114 EPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRR 173
PC DGWVYD S+IV ++NLVC + QS AG L G+ G +DRFGR+
Sbjct: 119 GPCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRK 176
Query: 174 LVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLV 233
L L + L AV G AF+P + LFR L G M TL+ E+ + +R V
Sbjct: 177 LCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTV 236
Query: 234 MTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLD 293
+ + F+ G +AY + W LQL VS+P FL LY W + ES RWLL+ R
Sbjct: 237 AIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNT 296
Query: 294 WGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCIS 353
++ + +A NGK L P L EE + S L R P LR RT I
Sbjct: 297 EAIKIMDHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFIL 350
Query: 354 TLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASL 413
WF + GL L + A N++L ++ +V+IP AL+ + +GR +A S
Sbjct: 351 MYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSN 410
Query: 414 LLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQ 473
LLAG L + ++ L + +G G+ A I + ++EL+PT +R V +
Sbjct: 411 LLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCS 470
Query: 474 MAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 531
G I+ P + + + W LPL+++ + +L+ LLLPET+ + LP+T++D +
Sbjct: 471 SLCDIGGIITPFI-VFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAE 529
Query: 532 N 532
N
Sbjct: 530 N 530
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 223 bits (569), Expect = 3e-58
Identities = 155/505 (30%), Positives = 248/505 (49%), Gaps = 27/505 (5%)
Query: 40 FSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIP-PGP--NQRPHQCRRFR---- 92
F P HRC +P A+ S+ SP L ++P PGP P QCRR+
Sbjct: 42 FLGFTPDHRCRSP----GVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWN 97
Query: 93 QPQWQLLDPNATA-TSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSI 151
Q + +DP A+ T+ S PC DGWVY+ S+IV ++NLVC + + + QS
Sbjct: 98 QSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSS 155
Query: 152 YLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVA 211
G +G+ + G +DRFGR+L L + L A G A +P + +FR +
Sbjct: 156 VNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSK 215
Query: 212 GVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFL 271
+ L+ E+ R R V + ++ G + A VAY + W LQ V++P F
Sbjct: 216 AGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFF 275
Query: 272 CFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMG 331
LY W + ES RWL++ + ++ + +A NGK +L + + EE
Sbjct: 276 FLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGK-----SLPASLQRLRLEEETGKK 330
Query: 332 QPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIP 391
P+ L L+R P +R T I WF + GL + + G NI+L + +V+ P
Sbjct: 331 LNPSFLD-LVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFP 389
Query: 392 AKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTC 451
A +L + +GRR AAS ++AG LA+ +P ++ L+ ++ LG G+ A+
Sbjct: 390 AAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEI 449
Query: 452 ITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLV--RLLGVHGPW--LPLLVYGTVPVL 507
+ + ++EL+PT +R V + G I+ P + RL + W LPL+V+G + ++
Sbjct: 450 VCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNI---WLELPLMVFGVLGLV 506
Query: 508 SGLAALLLPETQSLPLPDTIQDVQN 532
+G LLLPET+ LP+TI++ +N
Sbjct: 507 AGGLVLLLPETKGKALPETIEEAEN 531
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 216 bits (549), Expect = 6e-56
Identities = 171/577 (29%), Positives = 260/577 (45%), Gaps = 43/577 (7%)
Query: 3 FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAP------LLDN 56
F + D VG GRFQ + + + F P H C P + N
Sbjct: 6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65
Query: 57 ----STAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEAD 112
S L S + + + + G +C R ++ L T +
Sbjct: 66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK----K 121
Query: 113 TEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGR 172
PCVDG++YD++ + ST V +WNLVCD L + Q +++ G+L+G+ G SDR GR
Sbjct: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181
Query: 173 RLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPL 232
R+VL + M + G AAAFA + + RF LA +G ++ +ME+ ++R
Sbjct: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
Query: 233 VMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLV---VSVPFFLCFLYSWWLAESARWLLTT 289
F+ G L A Y VR W L Q++ V+VPF LC W L E+ WLL+
Sbjct: 242 ASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILC---CWVLPETPFWLLSE 298
Query: 290 GRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRF- 348
GR +E ++ I K + LLS L + P ++ T ++ L +
Sbjct: 299 GR----YEEAQKIVDIMAKWNRASSCKLSELLS-----LDLQGPVSNSPTEVQKHNLSYL 349
Query: 349 --------RTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLL 400
RT L WF F+ +L+ LG N +L +GVV+IPA + +
Sbjct: 350 FYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAM 409
Query: 401 SHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELF 460
+GRR LA SL + L ++P + L A++G +GAAF I +Y++EL+
Sbjct: 410 DKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELY 469
Query: 461 PTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQS 520
PT++R AVG G M R +IL P L ++P L GT+ +LSG+ L LPET
Sbjct: 470 PTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLG 529
Query: 521 LPLPDTIQDV-----QNQAVKKATHGTLGNSVLKSTQ 552
L T ++ +N++ T NS L+ T+
Sbjct: 530 KRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTE 566
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 192 bits (489), Expect = 5e-49
Identities = 151/469 (32%), Positives = 215/469 (45%), Gaps = 26/469 (5%)
Query: 5 ELLDLVGGLGRFQ---VLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQA 61
++L+ VG G FQ L L + +C + F+ P H C +P A+
Sbjct: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFT---PDHHCQSP----GVAEL 58
Query: 62 SILGSLSPEALLAISIP---PGPNQRPHQCRRFR----QPQWQLLDPNAT-ATSWSEADT 113
S SP L ++P P QCRR+ Q +DP A+ AT+ S
Sbjct: 59 SQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPL 118
Query: 114 EPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRR 173
PC DGWVYD S+IV ++NLVC + QS AG L G+ G +DRFGR+
Sbjct: 119 GPCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRK 176
Query: 174 LVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLV 233
L L + L AV G AF+P + LFR L G M TL+ E+ + +R V
Sbjct: 177 LCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTV 236
Query: 234 MTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLD 293
+ + F+ G +AY + W LQL VS+P FL LY W + ES RWLL+ R
Sbjct: 237 AIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNT 296
Query: 294 WGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCIS 353
++ + +A NGK L P L EE + S L R P LR RT I
Sbjct: 297 EAIKIMDHIAQKNGK------LPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFIL 350
Query: 354 TLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASL 413
WF + GL L + A N++L ++ +V+IP AL+ + +GR +A S
Sbjct: 351 MYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSN 410
Query: 414 LLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 462
LLAG L + ++ L + +G G+ A I + ++EL+PT
Sbjct: 411 LLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPT 459
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 186 bits (472), Expect = 5e-47
Identities = 145/563 (25%), Positives = 258/563 (45%), Gaps = 38/563 (6%)
Query: 3 FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQAS 62
F+ LLD VG G FQ + + ++F C N++ +
Sbjct: 52 FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYC------NTSWILA 105
Query: 63 ILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122
+ LS L ++IP PN C + W L + + DT+ C DGW+Y
Sbjct: 106 VGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNL----DSIIQFGLNDTDTCQDGWIY 161
Query: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182
+ S ++ +++LVC K AQ +++AG+ +G+ +D+ GR + S L
Sbjct: 162 PDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLG 220
Query: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242
+ + G AF +F +Y FRF ++ +V G +++ +L EW R + L F+
Sbjct: 221 LIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFA 280
Query: 243 FGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRV 302
G L +AY + W LL LV + Y W L ES RWL+ G++ Q L
Sbjct: 281 VGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYA 340
Query: 303 AAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGF 362
A++N K + L E+ L R++++ AS+ + L T + + WF +
Sbjct: 341 ASVN-KKTIPSNLLDELQLP--RKKVTR----ASVLDFCKNRQLCKVTLVMSCVWFTVSY 393
Query: 363 TFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILA 422
T+F L+L ++ LG ++ + ++++PA++ + LL +GR+ +LA +LL A + L
Sbjct: 394 TYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLL 453
Query: 423 NTLVPH---------------EMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMT 467
+P E+ ++ + +L + A T +Y++EL PTVLR T
Sbjct: 454 LLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRAT 513
Query: 468 AVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTI 527
+GL +A+ GAIL + ++ LP+ + + +++ + LLPET+ PL +++
Sbjct: 514 GLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
Query: 528 ---QDVQNQAVKKATHGTLGNSV 547
++N+ T T + V
Sbjct: 572 NHSSQIRNKVKDMKTKETSSDDV 594
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 182 bits (462), Expect = 7e-46
Identities = 132/440 (30%), Positives = 208/440 (47%), Gaps = 17/440 (3%)
Query: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
V+ S FTS I ++W L+ + A S + +G+ VG + G SDRFGR+ V +
Sbjct: 88 VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGF 146
Query: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
+ A F+P++ + + RFL+ G+ + LL E L ++ L
Sbjct: 147 ALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLF 206
Query: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
F+ G A + Y +R W L ++V++ + FL S ++ ES RWL + GRL + L+
Sbjct: 207 FAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALY 266
Query: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
+A N K +LT S + S L R L T I WF
Sbjct: 267 LIAKRNRKLKCTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVC 318
Query: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTLAASLLLAGL 418
++GL L LG +I+ G+++IP+ + L++ GR+ TL+A L L GL
Sbjct: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
Query: 419 CILANTLVPHE-----MGALRS-ALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472
L +P + + S +L++LG + AAF + IY+SEL+PTV+R +G
Sbjct: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438
Query: 473 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQN 532
M +R G I+ P + L LP +V+G + SGL +LLLPET + PL +T D+Q
Sbjct: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQV 498
Query: 533 QAVKKATHGTLGNSVLKSTQ 552
+ ++ L L Q
Sbjct: 499 YSYRRLGEEALSLQALDPQQ 518
>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
[Homo sapiens]
Length = 558
Score = 137 bits (345), Expect = 3e-32
Identities = 157/551 (28%), Positives = 232/551 (42%), Gaps = 59/551 (10%)
Query: 4 SELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASI 63
+ +L GG GR + L A V + L E A P+ C + T
Sbjct: 5 ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHC----RPDPTLLPPA 60
Query: 64 LGSLSPEALLAISIPP-GPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122
L +L ALL +IP GP + P + P + L P A P W
Sbjct: 61 LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRA---------PRPSSWA- 108
Query: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182
S + WNLVC P+ Q +L G L+G G DRFGRR V S +
Sbjct: 109 --SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVL 166
Query: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242
+G + A A +FP + R L +AG ++ +E L + L FS
Sbjct: 167 TTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLE--------LCDPPHRLAFS 218
Query: 243 FGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLLTTGR 291
G GL + V A V+DW LLQ + ++ L L+ + A ES WLL TG+
Sbjct: 219 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQ 278
Query: 292 LDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLRMPGL 346
+ + LWR A +G G +L L +A + + P + LG L
Sbjct: 279 VARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL------ 332
Query: 347 RFRTCISTLCWFAFGFTFF---GLALDLQ-ALGSNI--FLLQMFIGV-VDIPAKMGALLL 399
RT ++ GF+ G+ + +L + F L F+ ++ A + LL
Sbjct: 333 --RTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLT 390
Query: 400 LSHLGRRPTLAASLLLAGLC-ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSE 458
GRRP L ++ GL +L + G L+VLGL A +++++E
Sbjct: 391 ADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAE 450
Query: 459 LFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPET 518
+FPTV+R +GL A G GPL L G G +L +V+ ++ VL+ L LLLPE+
Sbjct: 451 VFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPES 510
Query: 519 QSLPLPDTIQD 529
+S LP ++QD
Sbjct: 511 RSRGLPQSLQD 521
>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
[Homo sapiens]
Length = 560
Score = 131 bits (329), Expect = 2e-30
Identities = 155/551 (28%), Positives = 228/551 (41%), Gaps = 57/551 (10%)
Query: 4 SELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASI 63
+ +L GG GR + L A V + L E A P+ C + T
Sbjct: 5 ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHC----RPDPTLLPPA 60
Query: 64 LGSLSPEALLAISIPP-GPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122
L +L ALL +IP GP + C L P A P W
Sbjct: 61 LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRA---------PRPSSWA- 110
Query: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182
S + WNLVC P+ Q +L G L+G G DRFGRR V S +
Sbjct: 111 --SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVL 168
Query: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242
+G + A A +FP + R L +AG ++ +E L + L FS
Sbjct: 169 TTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLE--------LCDPPHRLAFS 220
Query: 243 FGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLLTTGR 291
G GL + V A V+DW LLQ + ++ L L+ + A ES WLL TG+
Sbjct: 221 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQ 280
Query: 292 LDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLRMPGL 346
+ + LWR A +G G +L L +A + + P + LG L
Sbjct: 281 VARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL------ 334
Query: 347 RFRTCISTLCWFAFGFTFF---GLALDLQ-ALGSNI--FLLQMFIGV-VDIPAKMGALLL 399
RT ++ GF+ G+ + +L + F L F+ ++ A + LL
Sbjct: 335 --RTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLT 392
Query: 400 LSHLGRRPTLAASLLLAGLC-ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSE 458
GRRP L ++ GL +L + G L+VLGL A +++++E
Sbjct: 393 ADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAE 452
Query: 459 LFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPET 518
+FPTV+R +GL A G G L L G G +L +V+ ++ VL+ L LLLPE+
Sbjct: 453 VFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPES 512
Query: 519 QSLPLPDTIQD 529
+S LP ++QD
Sbjct: 513 RSRGLPQSLQD 523
>gi|169202895 PREDICTED: similar to solute carrier family 22, member
24 [Homo sapiens]
Length = 139
Score = 129 bits (323), Expect = 9e-30
Identities = 67/132 (50%), Positives = 81/132 (61%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M F LLD VGGLGRFQ+ + L +SI+ +LENF A +P H W +LDN T
Sbjct: 1 MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G+LS ALL ISIP N RP +CR F PQW LL N T ++ SE +TEPCV GW
Sbjct: 61 DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120
Query: 121 VYDRSIFTSTIV 132
VY +S F TIV
Sbjct: 121 VYHQSSFLFTIV 132
>gi|239750073 PREDICTED: similar to solute carrier family 22, member
24 [Homo sapiens]
Length = 139
Score = 129 bits (323), Expect = 9e-30
Identities = 67/132 (50%), Positives = 81/132 (61%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M F LLD VGGLGRFQ+ + L +SI+ +LENF A +P H W +LDN T
Sbjct: 1 MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G+LS ALL ISIP N RP +CR F PQW LL N T ++ SE +TEPCV GW
Sbjct: 61 DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120
Query: 121 VYDRSIFTSTIV 132
VY +S F TIV
Sbjct: 121 VYHQSSFLFTIV 132
>gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo
sapiens]
Length = 139
Score = 129 bits (323), Expect = 9e-30
Identities = 67/132 (50%), Positives = 81/132 (61%)
Query: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
M F LLD VGGLGRFQ+ + L +SI+ +LENF A +P H W +LDN T
Sbjct: 1 MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60
Query: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
+ G+LS ALL ISIP N RP +CR F PQW LL N T ++ SE +TEPCV GW
Sbjct: 61 DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120
Query: 121 VYDRSIFTSTIV 132
VY +S F TIV
Sbjct: 121 VYHQSSFLFTIV 132
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.138 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,087,025
Number of Sequences: 37866
Number of extensions: 875065
Number of successful extensions: 2948
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2783
Number of HSP's gapped (non-prelim): 109
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.