Guide to the Human Genome
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Search of human proteins with 24308394

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24308394 hypothetical protein LOC140893 [Homo sapiens]
         (664 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24308394 hypothetical protein LOC140893 [Homo sapiens]            1348   0.0  
gi|42718017 retinoblastoma binding protein 8 isoform b [Homo sap...   138   2e-32
gi|42718015 retinoblastoma binding protein 8 isoform a [Homo sap...   138   2e-32
gi|4506441 retinoblastoma binding protein 8 isoform a [Homo sapi...   138   2e-32
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         75   2e-13
gi|163965366 nascent polypeptide-associated complex alpha subuni...    74   6e-13
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    71   3e-12
gi|210032580 SET domain containing 1B [Homo sapiens]                   66   1e-10
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    64   4e-10
gi|150170670 piccolo isoform 2 [Homo sapiens]                          62   2e-09
gi|150378539 piccolo isoform 1 [Homo sapiens]                          62   2e-09
gi|116256464 hypothetical protein LOC343990 [Homo sapiens]             62   2e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        59   1e-08
gi|188536004 zinc finger protein 469 [Homo sapiens]                    59   2e-08
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    58   3e-08
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    57   5e-08
gi|91208420 bassoon protein [Homo sapiens]                             56   9e-08
gi|50428935 BPY2 interacting protein 1 [Homo sapiens]                  56   9e-08
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         56   1e-07
gi|146219832 myosin light chain kinase 3 [Homo sapiens]                56   1e-07
gi|169658367 BAH domain and coiled-coil containing 1 [Homo sapiens]    55   2e-07
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    55   2e-07
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]         55   3e-07
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   54   5e-07
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   54   5e-07
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   54   5e-07
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    54   5e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    54   5e-07
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              54   5e-07
gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Ho...    54   5e-07

>gi|24308394 hypothetical protein LOC140893 [Homo sapiens]
          Length = 664

 Score = 1348 bits (3489), Expect = 0.0
 Identities = 664/664 (100%), Positives = 664/664 (100%)

Query: 1   MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKEN 60
           MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKEN
Sbjct: 1   MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKEN 60

Query: 61  LRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKE 120
           LRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKE
Sbjct: 61  LRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKE 120

Query: 121 EVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRG 180
           EVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRG
Sbjct: 121 EVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRG 180

Query: 181 EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240
           EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN
Sbjct: 181 EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240

Query: 241 GTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHL 300
           GTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHL
Sbjct: 241 GTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHL 300

Query: 301 QSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLA 360
           QSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLA
Sbjct: 301 QSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLA 360

Query: 361 QQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPA 420
           QQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPA
Sbjct: 361 QQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPA 420

Query: 421 GPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQ 480
           GPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQ
Sbjct: 421 GPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQ 480

Query: 481 SGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPP 540
           SGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPP
Sbjct: 481 SGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPP 540

Query: 541 PHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGP 600
           PHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGP
Sbjct: 541 PHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGP 600

Query: 601 ECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660
           ECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP
Sbjct: 601 ECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660

Query: 661 WEET 664
           WEET
Sbjct: 661 WEET 664


>gi|42718017 retinoblastoma binding protein 8 isoform b [Homo
           sapiens]
          Length = 867

 Score =  138 bits (347), Expect = 2e-32
 Identities = 80/173 (46%), Positives = 108/173 (62%), Gaps = 4/173 (2%)

Query: 4   FMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRV 63
           F +   +LKE H++EV GLQ K+ +L  ER  DAQR+EE F+KN QLREQQK L E ++V
Sbjct: 20  FKDLWTKLKECHDREVQGLQVKVTKLKQERILDAQRLEEFFTKNQQLREQQKVLHETIKV 79

Query: 64  LENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVK 123
           LE+RLRAGLCDRC VT+E  RK+QQEFE+   QNL+ I  L NE N L+EEN+ L E+++
Sbjct: 80  LEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQ 139

Query: 124 RLRVLGDRPKPRAK---EGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           + ++  D+    A+   E    P SP+   S  G   +  K        E+ H
Sbjct: 140 Q-KIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH 191


>gi|42718015 retinoblastoma binding protein 8 isoform a [Homo
           sapiens]
          Length = 897

 Score =  138 bits (347), Expect = 2e-32
 Identities = 80/173 (46%), Positives = 108/173 (62%), Gaps = 4/173 (2%)

Query: 4   FMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRV 63
           F +   +LKE H++EV GLQ K+ +L  ER  DAQR+EE F+KN QLREQQK L E ++V
Sbjct: 20  FKDLWTKLKECHDREVQGLQVKVTKLKQERILDAQRLEEFFTKNQQLREQQKVLHETIKV 79

Query: 64  LENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVK 123
           LE+RLRAGLCDRC VT+E  RK+QQEFE+   QNL+ I  L NE N L+EEN+ L E+++
Sbjct: 80  LEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQ 139

Query: 124 RLRVLGDRPKPRAK---EGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           + ++  D+    A+   E    P SP+   S  G   +  K        E+ H
Sbjct: 140 Q-KIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH 191


>gi|4506441 retinoblastoma binding protein 8 isoform a [Homo
           sapiens]
          Length = 897

 Score =  138 bits (347), Expect = 2e-32
 Identities = 80/173 (46%), Positives = 108/173 (62%), Gaps = 4/173 (2%)

Query: 4   FMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRV 63
           F +   +LKE H++EV GLQ K+ +L  ER  DAQR+EE F+KN QLREQQK L E ++V
Sbjct: 20  FKDLWTKLKECHDREVQGLQVKVTKLKQERILDAQRLEEFFTKNQQLREQQKVLHETIKV 79

Query: 64  LENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVK 123
           LE+RLRAGLCDRC VT+E  RK+QQEFE+   QNL+ I  L NE N L+EEN+ L E+++
Sbjct: 80  LEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQ 139

Query: 124 RLRVLGDRPKPRAK---EGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           + ++  D+    A+   E    P SP+   S  G   +  K        E+ H
Sbjct: 140 Q-KIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH 191


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 149/693 (21%), Positives = 239/693 (34%), Gaps = 88/693 (12%)

Query: 4   FMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQ-RIEELFSKNHQLREQQKTLKENLR 62
           FM  L  L    ++ + G+ +  LEL  E  +  Q   E+L S   Q  ++ K  KE   
Sbjct: 101 FMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKE 160

Query: 63  VLENRLRAGLCDRCMVTQELARKRQ-----QEFESSHLQNLQRIFILTNEMNGLKEENET 117
               +       R   ++  + +R+     +E + SH ++ +      +     +++ +T
Sbjct: 161 SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKT 220

Query: 118 LKEEVKRLRVLGDRPKPRAKEGTSD---PPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQ 174
              E+    V    P  +    TSD    P P  +P P        K P   + ++++ +
Sbjct: 221 --PELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEP--------KEPSPEKNSKKEKE 270

Query: 175 GVGLRGEEKPAGHRTSPVAKISPGATLPE----SRAPDMSPQRISNQLHGTIAVVRPGSQ 230
               R   +      S     SP  T P     SR+   SP+R            RP  +
Sbjct: 271 KEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRR------------RPSPR 318

Query: 231 ACPADRG---PANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVD 287
             P+ R    P    PPP   RS  P     R  +  S   +S  S+ +   PK  PK  
Sbjct: 319 RRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRT 378

Query: 288 RLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQ 347
                + P      SP +SP      PS P     K R +     P +      +   + 
Sbjct: 379 S----SPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPT---PQQSNRTRKSRVSVS 431

Query: 348 DLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALA 407
             R  G +       + +   +  S  P  +P   E+         SE  E++G + A A
Sbjct: 432 PGRTSGKV------TKHKGTEKRESPSPAPKPRKVEL---------SESEEDKGGKMAAA 476

Query: 408 AAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKP----LDLSEWGRARGQD-----TPKP 458
            +     ++ +      +    +++++D   ++P    +   E GR R        +P P
Sbjct: 477 DSVQQRRQYRRQNQQSSSDSGSSSSSED---ERPKRSHVKNGEVGRRRRHSPSRSASPSP 533

Query: 459 AGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPM------DP 512
             +    SP      SP PP      + SP       +    P +    +P        P
Sbjct: 534 RKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSP 593

Query: 513 SRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSK---AEVLRPE 569
            R  P  Q   S P       T  P PPP  +  P P P     H  P K   + V +  
Sbjct: 594 RRYSPPIQRRYS-PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRR 652

Query: 570 SDELDETDTPGSEVGLSSQAEATTSTT---GEGPECICTQEHGQGPPRKRKRASEPGDKA 626
           S  L      GS    S++   +          P     Q     PP +R  +S P  + 
Sbjct: 653 SPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQ 712

Query: 627 SKKPS-RGRRKLTATEGPGSPRDAEDHSPSPNS 658
           S  PS R  R+++ T  P   + A   SPSP S
Sbjct: 713 SPSPSTRPIRRVSRTPEPKKIKKAA--SPSPQS 743



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 51/216 (23%), Positives = 83/216 (38%), Gaps = 21/216 (9%)

Query: 464 SLSPAAAHTASPEPPTQSGPL--------TRSPQALSNGTKGTRVPEQEEASTPMDPSRP 515
           S SP    + SP P  +S P+        +RSP+  +     +  PE++E  TP      
Sbjct: 169 SRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE-KTP-----E 222

Query: 516 LPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSK-AEVLRPESDELD 574
           LP   + +  P   E   T   L  P P+P P P+ P  + + +  K  E  RP S    
Sbjct: 223 LPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRS 282

Query: 575 ETDT---PGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRK---RKRASEPGDKASK 628
           ++ +     S      +    + +    P    +      P R+   R+    P  + S+
Sbjct: 283 KSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSR 342

Query: 629 KPSRGRRKLTATEGPGSPRDAEDHSPSPNSSPWEET 664
            P R RR+ +A+    S   +   S SP   P + T
Sbjct: 343 SPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRT 378



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/190 (24%), Positives = 69/190 (36%), Gaps = 38/190 (20%)

Query: 455 TPKPAGQHG-SLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPS 513
           +P+P  +H  S  P A  T+S  PP + G  + SPQ   + +  TR P +  + TP +P 
Sbjct: 675 SPQPNKRHSPSPRPRAPQTSSSPPPVRRGA-SSSPQRRQSPSPSTR-PIRRVSRTP-EPK 731

Query: 514 R------PLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPE-PSKAEVL 566
           +      P P S   +SS  S           PP P  P   Q P  +  P  P K    
Sbjct: 732 KIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVK---- 787

Query: 567 RPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKA 626
                                  +A + T    P     QE G    +K+K      DK 
Sbjct: 788 -----------------------KAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKK 824

Query: 627 SKKPSRGRRK 636
            KK  + +++
Sbjct: 825 HKKHKKHKKE 834



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 52/234 (22%), Positives = 72/234 (30%), Gaps = 38/234 (16%)

Query: 457 KPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPL 516
           +P+ Q  + +        PEP  +  P   SP+      K ++  +++E + P   SR  
Sbjct: 232 EPSVQEATSTSDILKVPKPEPIPE--PKEPSPE------KNSKKEKEKEKTRPRSRSRSK 283

Query: 517 PGSQLSLSSPGSTEDE-----------DTGRPLPPPHPQP----PPHPQPPDLDGHPEPS 561
             S+    SP  T                 RP P   P P    PP   PP        S
Sbjct: 284 SRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRS 343

Query: 562 KAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASE 621
                R  S  L  + +  S     S  +     T   P           PPR+R R S 
Sbjct: 344 PVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSP 403

Query: 622 PGDKASK-------KPSRGRRKLTATEGPGSPR--------DAEDHSPSPNSSP 660
           P     K       + S   RK   +  PG             +  SPSP   P
Sbjct: 404 PATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKP 457


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 138/577 (23%), Positives = 185/577 (32%), Gaps = 80/577 (13%)

Query: 129  GDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHR 188
            G +  P A   +  PPSP   P+P    A+T   P          +GV L  +E P    
Sbjct: 845  GSKDSP-ATTHSPTPPSPKGAPTPS---AVTPLSP----------KGVTLPPKETP---- 886

Query: 189  TSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANG-TPP--- 244
            T  V  +      P + AP  +P           A   P  +  PA   P    TPP   
Sbjct: 887  TPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAAT 946

Query: 245  ----------------PLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDR 288
                            P P  ++PPSP  + G +  S   A  P A T  +PK  P    
Sbjct: 947  PPSPKGGPATPSPKWAPTPPAATPPSP--KGGPATPSPKGAPTPPAATPPSPKGGPATPS 1004

Query: 289  LCLLNRPLSLHLQSPHSSPLA----------PAAAPSDPRLQDLKAREAEAWEEPTELLG 338
                  P ++   SP  SP A          PAA P  P+     A         T    
Sbjct: 1005 PKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPK-GSPAATPLPKGAPTTPAAT 1063

Query: 339  LPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGP- 397
            LPS   G     L+GA     A      +    +  P+G P P    P  P G  +  P 
Sbjct: 1064 LPSPKGGPATPSLKGA-PTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPH 1122

Query: 398  ENEGTRAALAAAGLSGGRHTQP--AGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDT 455
            +   T  A       GG  T P    P     T  +     A   P        A     
Sbjct: 1123 KGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAA---TP 1179

Query: 456  PKPAGQHGSLSPAAAHT--ASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPS 513
            P P G   + SP  A T  A+  P  + G  T SP+        T    +   +TP    
Sbjct: 1180 PSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKG 1239

Query: 514  RPLPGSQLSLSSPGSTEDEDTGRP-LPPPHPQP-PPHPQPPDLDG------HPEPSKAEV 565
             P        ++P +T     G P  PPP   P PP   PP L G      H       V
Sbjct: 1240 AP--------TTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAV 1291

Query: 566  LRPESDELDETDTP--GSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPG 623
            + P S +     +P  G+    ++   +   + G  P           PP  +   + P 
Sbjct: 1292 VTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPA 1351

Query: 624  DKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660
               S K   G    ++ EGP  P     H   P  +P
Sbjct: 1352 TTPSSK--GGPTTPSSKEGPTPPAATPSHKGGPAMTP 1386



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 138/561 (24%), Positives = 187/561 (33%), Gaps = 61/561 (10%)

Query: 134  PRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVA 193
            P + +G    PSP   P+P    A+T   P G   A    +G        PA   T P  
Sbjct: 993  PPSPKGGPATPSPKGAPTP---PAVTPPSPKGSPAATPFPKGAST----PPAA--TPPSP 1043

Query: 194  KISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPA------DRGPANGTP--PP 245
            K SP AT     AP      + +   G       G+   PA        GPA  +P   P
Sbjct: 1044 KGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP 1103

Query: 246  LPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPK-----LSPKVDRLCLLNRPLS--- 297
            +P  ++PPSP  + GL+      A    A T  +PK       PK         P S   
Sbjct: 1104 MPPAATPPSP--KGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1161

Query: 298  -LHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALH 356
             L    P  +P  PAA P  P+     A  +      T     PS   G+     +GA  
Sbjct: 1162 GLATPPPKGAPTTPAATPPSPK--GGLATPSPKGAPTTPAATPPSPKGGLATPSPKGA-P 1218

Query: 357  LLLAQQQLRARARAGSVRPRGQP-TPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGR 415
               A      +    +  P+G P TP    PS   G  +  P+   T  A     L GG 
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGL 1278

Query: 416  HTQP--AGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHT- 472
             T P    P  A  T  +     A   P        A     P P G  G+  P  A T 
Sbjct: 1279 ATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA---TPPSPKGSPGTPPPKGAPTP 1335

Query: 473  ASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTP------------MDPSRPLPGSQ 520
             +  PP+  G  T  P    +   G   P  +E  TP            M P  P  G  
Sbjct: 1336 PAVTPPSPKGTPT-LPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPA 1394

Query: 521  LSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPG 580
            +      S + + T   + P  P+  P   P   +G   PSK ++  P    +     P 
Sbjct: 1395 IP-----SPKGDPTSPAVIPLSPKKAP-ATPVTREGAATPSKGDLTPPAVTPVSLKKAPA 1448

Query: 581  SEVGLSSQAEATTSTTGEGPECICTQEHGQGPPR-KRKRASEPGDKASKKPSRGRRKLTA 639
            +         AT S+ G+      T    + PP  K+   S    KA   P+        
Sbjct: 1449 TSA--PKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLP 1506

Query: 640  TEGPGSPRDAEDHSPSPNSSP 660
               P SP++    +PS    P
Sbjct: 1507 AVIPSSPKEV-PATPSSRRDP 1526



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 108/459 (23%), Positives = 145/459 (31%), Gaps = 67/459 (14%)

Query: 221  TIAVVRPGSQACPADRGPANGTPP-----------------PLPARSSPPSPAYERGLSL 263
            T+ +V   S+ CP    P N   P                  LP   +PP      G+S 
Sbjct: 697  TLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISH 756

Query: 264  DSFLR--ASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQD 321
             S L   AS P     E P               L+    SP  SPL  + +P   R   
Sbjct: 757  TSALAPVASSPK----ECPTEDSGASATASSKGTLTYLADSP--SPLGVSVSPQTKRPPT 810

Query: 322  LKAREAEAWEEPTELLGLPSALAGMQDLRL-EGALHLLLAQQQLRARARAGSVRPRGQPT 380
             K          T +  L S ++ ++   L E +L    ++             P+G PT
Sbjct: 811  KKGSAGP----DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866

Query: 381  PGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDK 440
            P  + P  P G     P+   T + +       G    PA P   Q    + T       
Sbjct: 867  PSAVTPLSPKGVTLP-PKETPTPSVVNLPFPKEG----PATPAPKQAPALSMTSSSP--- 918

Query: 441  PLDLSEWGRARGQDTPKPAGQHGSLSPAAAHT--ASPEPPTQSGPLTRSPQALSNGTKGT 498
                      + + TP P G   S SP  A T  A+  P  + GP T SP+        T
Sbjct: 919  ---------KKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAAT 969

Query: 499  RVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRP-LPPPHPQP-PPHPQPPDLDG 556
                +   +TP     P P        P +T     G P  P P   P PP   PP    
Sbjct: 970  PPSPKGGPATPSPKGAPTP--------PAATPPSPKGGPATPSPKGAPTPPAVTPPS--- 1018

Query: 557  HPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKR 616
             P+ S A    P+        TP S  G      AT    G       T    +G P   
Sbjct: 1019 -PKGSPAATPFPKGASTPPAATPPSPKG---SPAATPLPKGAPTTPAATLPSPKGGPATP 1074

Query: 617  KRASEPGDKASKKPS-RGRRKLTATEGPGSPRDAEDHSP 654
                 P   A+  PS +G     + +G   P  A   SP
Sbjct: 1075 SLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSP 1113



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 119/532 (22%), Positives = 185/532 (34%), Gaps = 83/532 (15%)

Query: 132  PKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSP 191
            P P+    +S P      P+P G   +    P   +E                   R  P
Sbjct: 1479 PAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSS------------RRDP 1526

Query: 192  VAKISPGATLPESRAP-DMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPAR- 249
            +A   P ATL   + P  ++P+          A++ P        + PA  TP   PA  
Sbjct: 1527 IA---PTATLLSKKTPATLAPKE---------ALIPPAMTVPSPKKTPAIPTPKEAPATP 1574

Query: 250  -----SSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPH 304
                 SSPP+          S      P A+T  +PK +P    +   +        +P 
Sbjct: 1575 SSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPK 1634

Query: 305  SSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLG--LPSALAGMQDLRLEGALHLLLAQQ 362
             +P +P   PS   L+D     A      T  +G  +P A  G+   +   AL  +L   
Sbjct: 1635 GTPTSPPVTPSS--LKDSPTSPASV----TCKMGATVPQASKGLPAKKGPTALKEVLVAP 1688

Query: 363  Q------LRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRH 416
                   + A  R G    +   T   + P     + S+GP +    A L        + 
Sbjct: 1689 APESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKT 1748

Query: 417  TQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPE 476
             +      + +   A  +  A   PL  + + +      PKP         +A+ +A+P 
Sbjct: 1749 AKGKDASHSPKGPLAPPESKA-STPLTAAAFEKV----LPKPE--------SASVSAAPS 1795

Query: 477  PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGR 536
            PP  S PL  SP         T  P+Q+    P  P   L     S S P +  DED   
Sbjct: 1796 PPV-SLPLAPSPVP-------TLPPKQQ--FLPSSPGLVLE----SPSKPLAPADEDELL 1841

Query: 537  PLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRP---------ESDELDETDTPGSEVGLSS 587
            PL PP P     P    L   P P  A +  P         ++++   T++   E     
Sbjct: 1842 PLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPEL 1901

Query: 588  QAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSR-GRRKLT 638
            + + +T  T +  +     E  + P  K K+ S    KA K  S+ G R++T
Sbjct: 1902 EEQDSTQATTQQAQLAAAAEIDEEPVSKAKQ-SRSEKKARKAMSKLGLRQVT 1952



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 7/121 (5%)

Query: 197 PGATLPE--SRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPS 254
           PG TLP   S AP   P   +NQ     +     S        P + +   LP  ++P +
Sbjct: 41  PGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPF-PQSSSGTALPLGTAPEA 99

Query: 255 PAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAP 314
           P +   L          P+A+   +P ++P +      + PL+L   +PHS   + A  P
Sbjct: 100 PTFLPNLIGPPI----SPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPP 155

Query: 315 S 315
           +
Sbjct: 156 N 156


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 149/575 (25%), Positives = 193/575 (33%), Gaps = 110/575 (19%)

Query: 131 RPKPRAKEGTSDPPS--PLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHR 188
           RP P A+     PP+  P    S     + TE  P           G GL   ++PA   
Sbjct: 182 RPAPSARPR---PPTEGPRKSVSSASEHSTTEPSPAARRRPSA---GGGL---QRPASRS 232

Query: 189 TSPVAK--ISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGS------QACPADRGPAN 240
            S  A    SP  + P +R    +P   S      +  +RP         A PA  GP +
Sbjct: 233 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA-LGPLS 291

Query: 241 GTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPL--SL 298
            +P   P+ S+PPSP             ++ PS  T  +P  +P       L  P   + 
Sbjct: 292 SSPLATPSPSAPPSP-------------SAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 338

Query: 299 H--LQSPHSSPLA--PAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGA 354
           H  L SP  SPLA  P  AP    L  L+A  +     P   L  PS  A         A
Sbjct: 339 HSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN-----ALA 393

Query: 355 LHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGG 414
           +HLL A                  P+P    P  P  S    P    T  + A   L+  
Sbjct: 394 VHLLQAPFS-------------PPPSPPVQAPFSPPASPPVSP--SATPPSQAPPSLAAP 438

Query: 415 RHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARG-------------QDTPKPAGQ 461
               P  P  +     +AT       PL       A+              Q  P P   
Sbjct: 439 PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPAS 498

Query: 462 ---HGSLSPAAAHTASP--EPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSR-- 514
                  SP+A+   SP   PP Q+ P+  +P          +VP    AS  +   R  
Sbjct: 499 FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL--------LQVPPSPPASPTLQAPRRP 550

Query: 515 PLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELD 574
           P PG   S+S P  T     G P PPP   P      PDL GH   S +    PE     
Sbjct: 551 PTPGPDTSVSGPRLTLALAPGPP-PPPSRSPSSTLSGPDLAGH---SSSATSTPE----- 601

Query: 575 ETDTPGSEVGLSSQAEATTSTTGEGPEC-ICTQEHGQGPPRKRKRASEPGDKASKKPSRG 633
             +  G + G    A A+     E   C       G  PP   + A  PG      P+ G
Sbjct: 602 --ELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGA--PGAPLPWPPATG 657

Query: 634 RRK------LTATEGPGSPRDAE---DHSPSPNSS 659
                    +  TEGP S   A    D  PSP +S
Sbjct: 658 PGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 692



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 129/552 (23%), Positives = 171/552 (30%), Gaps = 86/552 (15%)

Query: 117 TLKEEVKRLRVLGDRPKPRAKEGTSDPP----SPLLLPSPGGWKAITEKPPGGHEEAEED 172
           T+ E   R         P +  G   PP    SP  + SPG     T   P G +     
Sbjct: 69  TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128

Query: 173 HQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQA- 231
            +    RG+   A  R++  A      + P    P  +  R S      + + RP   A 
Sbjct: 129 AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR 188

Query: 232 -CPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLS------- 283
             P   GP           ++ PSPA  R  S    L+     +++  A  LS       
Sbjct: 189 PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 248

Query: 284 --------------PKVDRLCLLNRP--------LSLHLQSPHSSPLA---PAAAPS--- 315
                         PK   L  L  P         +  L    SSPLA   P+A PS   
Sbjct: 249 SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA 308

Query: 316 DPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRP 375
            P LQ L +  A    + T  LG P+            A H  L    L   A      P
Sbjct: 309 PPSLQTLPSPPATPPSQATTSLGSPTL----------QATHSFLPSPPLSPLATPPPQAP 358

Query: 376 RGQPTPGEMLPSLPVGSDSEGP---ENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAA 432
                P    P  P  S    P    +     ALA   L       P+ P +A  +  A+
Sbjct: 359 PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 418

Query: 433 TQDCALDKPLDLSEWGRARG--QDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQA 490
                   P   +    A    Q  P P       SP  + +A+P PP    PL   P  
Sbjct: 419 PPVSPSATPPSQAPPSLAAPPLQVPPSPPA-----SPPMSPSATP-PPQAPPPLAAPPLQ 472

Query: 491 LSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSL--SSPGSTEDEDTGRPLPPPHPQPPPH 548
           L+      + P Q   +    P + LP    S    +P S        PL  P PQ PP 
Sbjct: 473 LA------KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 526

Query: 549 PQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEH 608
              P L   P P  +  L+          TPG +  +S            GP        
Sbjct: 527 LAAPLLQVPPSPPASPTLQAPR----RPPTPGPDTSVS------------GPRLTLALAP 570

Query: 609 GQGPPRKRKRAS 620
           G  PP  R  +S
Sbjct: 571 GPPPPPSRSPSS 582



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 94/363 (25%), Positives = 115/363 (31%), Gaps = 85/363 (23%)

Query: 365 RARARAGSV-RPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSG---------- 413
           R +A+AG+  R      PG + P  P       P        L AAG  G          
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64

Query: 414 -GRHTQP-----AGPGRAQRTEAAATQDCALD----KPLDLSEWGRARGQDTPKPAGQHG 463
            G  T P     AGP R  R  A+   + A       P  +S  GRA G   P P GQ G
Sbjct: 65  IGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG 124

Query: 464 ---------------------SLSPAAAH-TASPEPPTQSGPLTRSPQALSNG------- 494
                                +LS  A   T+ P P T S  + R  +A           
Sbjct: 125 LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA 184

Query: 495 --------TKGTR--VPEQEEAST--PMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPH 542
                   T+G R  V    E ST  P   +R  P +   L  P S     +  PL  P 
Sbjct: 185 PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 244

Query: 543 PQPPPHPQPPDLDGH---PEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEG 599
              P     P    H   P+P   + LRP        D   +   LSS   AT S +   
Sbjct: 245 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS--- 301

Query: 600 PECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHS--PSPN 657
                       PP  +   S P    S+          AT   GSP     HS  PSP 
Sbjct: 302 -----APPSPSAPPSLQTLPSPPATPPSQ----------ATTSLGSPTLQATHSFLPSPP 346

Query: 658 SSP 660
            SP
Sbjct: 347 LSP 349


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 128/518 (24%), Positives = 184/518 (35%), Gaps = 88/518 (16%)

Query: 155  WKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPD-----M 209
            +++ +E  P   E+ EE      +  EE+        VA+ S  +  PE    D     +
Sbjct: 1121 FESSSESSPSSSEDEEEV-----VAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAAL 1175

Query: 210  SPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPS----PAYERGLSLD- 264
            +P   +    G    V   ++A   +  P+    PPLP     P+    P  E GLS + 
Sbjct: 1176 APGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEG 1235

Query: 265  SFLRASRPSAMTHEA-PKLSPK--------VDRLCLLNRPLSLHLQSPHSSPLAPAAAPS 315
            + L +  P A   EA P LSP+        V+    +  PL L    P   P  P + P 
Sbjct: 1236 AMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPP 1295

Query: 316  DPRLQDLK----AREAEAWEEPTELLGLPSALAGMQDLRLE------------GALHLLL 359
            +P   D        E  A + P    GL  +LA  Q                 G+  L L
Sbjct: 1296 EPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSL 1355

Query: 360  AQQQLRAR-----ARAGSVRPRGQP-TPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSG 413
            +  Q+        A + S+   G P TPG      P  S+  GP        L    L  
Sbjct: 1356 SSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGP------LLLPVCPLPT 1409

Query: 414  GRHTQPAGP-GRAQRTEAAATQDCALDKPLDLSEWGRARGQ---DTPKPAGQHGSLS--- 466
            GR  + +GP       E        L  PL L+     R Q    TP P      L+   
Sbjct: 1410 GRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCP 1469

Query: 467  ------PAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQ 520
                  P     + P   +  GPL R P   + G +   +P Q +  TP+ PS   P + 
Sbjct: 1470 PPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQ--TPVFPSTHDPRTV 1527

Query: 521  LSLSSPGSTEDEDTGRPLPPPH--PQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDT 578
                   + +  + G P PPP   PQPPP P PP +    EP+K      ++    E   
Sbjct: 1528 -------TLDFRNAGIPAPPPPLPPQPPPPPPPPPV----EPTKLPFKELDNQWPSEAIP 1576

Query: 579  PGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKR 616
            PG               T E  E   ++   + PP+KR
Sbjct: 1577 PG--------PRGRDEVTEEYMELAKSRGPWRRPPKKR 1606



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 93/396 (23%), Positives = 132/396 (33%), Gaps = 73/396 (18%)

Query: 211 PQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRAS 270
           P +   Q   T A   P +QA PA    +  +P   P    PP P  E   +  +F   +
Sbjct: 367 PFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPP--EEPTATAAF--GA 422

Query: 271 RPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAW 330
           R S     AP   P       L     L  + P + P  P   P D    +L  R    W
Sbjct: 423 RDSGEFRRAPAPPP-------LPPAEPLAKEKPGTPPGPP---PPDTNSMELGGRPTFGW 472

Query: 331 E-EPTELLGLP---SALAGMQDLR--LEGALHLLLAQQQ-----LRARARAGSVRPRGQP 379
             EP +  G P   S+ AG +     L+  + +LL +Q+     LR       ++  G P
Sbjct: 473 SPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSP 532

Query: 380 ---TPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDC 436
              +  ++ P  P G++S+ P   G     +    +G     P               D 
Sbjct: 533 ISSSSSQLSPLAPFGTNSQ-PGFRGPTPPSSRPSSTGLEDISPT-----------PLPDS 580

Query: 437 ALDKPLDLSEWGRARGQD-TPKPAGQHGSLSPAAAHTASPEPPTQ--------------- 480
             D+ LDL    R   +   P PAG     +  A        PT                
Sbjct: 581 DEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDME 640

Query: 481 -------SGPLTRS----PQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGST 529
                  S P+T +    P  ++ G      P     + P+ P    P     L  P   
Sbjct: 641 ISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFP----PLPPPPPP 696

Query: 530 EDEDTGRPLPPPHPQPPPHPQP--PDLDGHPEPSKA 563
                G P+PPP P PPP P P  P +   P P  A
Sbjct: 697 PPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPA 732


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 153/592 (25%), Positives = 196/592 (33%), Gaps = 114/592 (19%)

Query: 131 RPKPRAKEGTSDPPS--PLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHR 188
           RP P A+     PP+  P    S     + TE  P           G GL   ++PA   
Sbjct: 191 RPAPSARPR---PPTEGPRKSVSSASEHSTTEPSPAARRRPSA---GGGL---QRPASRS 241

Query: 189 TSPVAK--ISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPA-DRGPANG---- 241
            S  A    SP  + P +R    +P   S      +  +RP     P  D  PA G    
Sbjct: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 242 ----TPPP---LPARSSPPSPAYERGLSLDSFLR----------ASRPSAMTHEAPKLSP 284
               TP P   L +++ P  PA     SL   L           ++ PS  T  +P  +P
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP 361

Query: 285 KVDRLCLLNRPL--SLH--LQSPHSSPLA--PAAAPSDPRLQDLKAREAEAWEEPTELLG 338
                  L  P   + H  L SP  SPLA  P  AP    L  L+A  +     P   L 
Sbjct: 362 PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLA 421

Query: 339 LPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPE 398
            PS  A         A+HLL A                  P+P    P  P  S    P 
Sbjct: 422 TPSPQAPNAL-----AVHLLQAPFS-------------PPPSPPVQAPFSPPASPPVSPS 463

Query: 399 NEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKP 458
              T  + A   L+      P  P  +     +AT       PL       A+      P
Sbjct: 464 --ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP 521

Query: 459 A-----------------GQHGSLSPAAAHTASP--EPPTQSGPLTRSPQALSNGTKGTR 499
           A                 GQ    SP+A+   SP   PP Q+ P+  +P          +
Sbjct: 522 ALATPPLQALPSPPASFPGQ-APFSPSASLPMSPLATPPPQAPPVLAAPLL--------Q 572

Query: 500 VPEQEEASTPMDPSR--PLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGH 557
           VP    AS  +   R  P PG   S+S P  T     G P PPP   P      PDL GH
Sbjct: 573 VPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP-PPPSRSPSSTLSGPDLAGH 631

Query: 558 PEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPEC-ICTQEHGQGPPRKR 616
              S +    PE       +  G + G    A A+     E   C       G  PP   
Sbjct: 632 ---SSSATSTPE-------ELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 681

Query: 617 KRASEPGDKASKKPSRGRRK------LTATEGPGSPRDAE---DHSPSPNSS 659
           + A  PG      P+ G         +  TEGP S   A    D  PSP +S
Sbjct: 682 RGA--PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 731



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 90/331 (27%), Positives = 107/331 (32%), Gaps = 57/331 (17%)

Query: 369 RAGSVRPRGQ---------PTPGEMLPSLPVGSDSEGPENEGTRAALAAA----GLSGGR 415
           RAG  R  G          P  G    + P  + S GP +   RA+        G  G R
Sbjct: 76  RAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 135

Query: 416 HTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLS-------PA 468
            +      R + TEA      +     D S  G   G  TP PA    S +       P 
Sbjct: 136 ISAEETVARGKATEAPKRSALSAGARRDTS--GPTPG--TPSPAMARRSRAAGTEVGLPR 191

Query: 469 AAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEAST----PMDPSRPLPGSQLSLS 524
            A +A P PPT+ GP      A  + T       +   S         SR L  S   LS
Sbjct: 192 PAPSARPRPPTE-GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250

Query: 525 SPGSTEDEDTGRPLPPPHP-QPPPHP----QPPDLDGHPEPSKAEVLRPESDELDETDTP 579
           SP  +     G P  P HP QP P      +PP +   P    A  L P S       TP
Sbjct: 251 SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT-PPRKDAAPALGPLSS--SPLATP 307

Query: 580 GSEVGLSSQAEATTSTTGEGPECIC--------TQEHGQGPPRKRKRASEPGDKASKKPS 631
                L SQA  T   T       C               PP  +   S P    S+   
Sbjct: 308 SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ--- 364

Query: 632 RGRRKLTATEGPGSPRDAEDHS--PSPNSSP 660
                  AT   GSP     HS  PSP  SP
Sbjct: 365 -------ATTSLGSPTLQATHSFLPSPPLSP 388



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 134/566 (23%), Positives = 174/566 (30%), Gaps = 118/566 (20%)

Query: 134 PRAKEGTSDPP----SPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRT 189
           P +  G   PP    SP  + SPG     T   P G +      +    RG+   A  R+
Sbjct: 95  PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 154

Query: 190 SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACP---------------- 233
           +  A      + P    P  +  R S      + + RP   A P                
Sbjct: 155 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 214

Query: 234 ---------ADRGPANG---------------TPPPLPARSSPPSPAYERGLSLDS---- 265
                    A R P+ G               TP   PARS P +    R  +  S    
Sbjct: 215 HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP 274

Query: 266 -FLRASRPSAMT----HEAPKLSPKVDRLCLLNRPLSLHLQS---------PHSS----- 306
             L+A RP  +T      AP L P          P S  LQS         PHSS     
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP-SAALQSQAPPTLPATPHSSSLTCQ 333

Query: 307 -----PLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQ 361
                PLAP +  + P LQ L +  A    + T  LG P+            A H  L  
Sbjct: 334 LATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL----------QATHSFLPS 383

Query: 362 QQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGP---ENEGTRAALAAAGLSGGRHTQ 418
             L   A      P     P    P  P  S    P    +     ALA   L       
Sbjct: 384 PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443

Query: 419 PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARG--QDTPKPAGQHGSLSPAAAHTASPE 476
           P+ P +A  +  A+        P   +    A    Q  P P       SP  + +A+P 
Sbjct: 444 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA-----SPPMSPSATP- 497

Query: 477 PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSL--SSPGSTEDEDT 534
           PP    PL   P  L+      + P Q   +    P + LP    S    +P S      
Sbjct: 498 PPQAPPPLAAPPLQLA------KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP 551

Query: 535 GRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTS 594
             PL  P PQ PP    P L   P P  +  L+          TPG +  +S        
Sbjct: 552 MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR----RPPTPGPDTSVS-------- 599

Query: 595 TTGEGPECICTQEHGQGPPRKRKRAS 620
               GP        G  PP  R  +S
Sbjct: 600 ----GPRLTLALAPGPPPPPSRSPSS 621



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 136/572 (23%), Positives = 184/572 (32%), Gaps = 119/572 (20%)

Query: 130 DRPKPRAKEGTSDPPSP-LLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHR 188
           D+ K  A   T    +P LL P P G    + +PP     A     G       KP   R
Sbjct: 6   DKAKAGAAARTPAARAPGLLTPRPPG----SPRPPPPVTPAALRVLGAAGAVGRKPLAER 61

Query: 189 TSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLP- 247
              +     GAT+PES AP   P R +    GT       S   PA R PA+G     P 
Sbjct: 62  AGGIG----GATIPES-APRAGPTRSA----GT-------SSRNPASRPPASGRGERAPP 105

Query: 248 ARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSP 307
           A+++ P P    G +  +    +RP  +  +  ++S +                      
Sbjct: 106 AKNTSPGPVSSPGRASGT----TRPGPLGQKGLRISAE--------------------ET 141

Query: 308 LAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRAR 367
           +A   A   P+   L A        PT   G PS                 +A++   A 
Sbjct: 142 VARGKATEAPKRSALSAGARRDTSGPTP--GTPSPA---------------MARRSRAAG 184

Query: 368 ARAGSVRPR--GQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRA 425
              G  RP    +P P    P   V S SE    E + AA       GG   +PA   R+
Sbjct: 185 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ-RPAS--RS 241

Query: 426 QRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHG----SLSPAAAHTASPEPPTQS 481
             + A      A   P              PKP G        ++P     A    P  S
Sbjct: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 482 GPL-TRSPQALSNGTKGTRVPEQEEAS-------TPMD---PSRPLPGSQLSLSSPGSTE 530
            PL T SP A         +P    +S       TP+    PS   P S  +L SP +T 
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP 361

Query: 531 DEDTGR--------------------PLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPES 570
                                     PL  P PQ PP    P L   P P  +  L P +
Sbjct: 362 PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLA 421

Query: 571 DELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKP 630
                T +P +   L+        +    P      +    PP     AS P   ++  P
Sbjct: 422 -----TPSPQAPNALAVHLLQAPFSPPPSPPV----QAPFSPP-----ASPPVSPSATPP 467

Query: 631 SRGRRKLTA--TEGPGSPRDAEDHSPSPNSSP 660
           S+    L A   + P SP  +   SPS    P
Sbjct: 468 SQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 499


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 113/473 (23%), Positives = 168/473 (35%), Gaps = 63/473 (13%)

Query: 93  SHLQNLQRIFILTNEMN--GLKEENETLKEEV--KRLRVLGDRPKPRAKEGTSDPPSPLL 148
           S +  L  +  + N+ N   L  ++E  +EE   K+  V  ++ KP   EG   PP    
Sbjct: 158 SEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKP---EGIIKPPLQQQ 214

Query: 149 LPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPD 208
            P P     I ++   G +  ++D       G  K    +     K  P  T    + P 
Sbjct: 215 PPKP-----IPKQQGPGRDPLQQD-------GTPKSISSQQPEKIKSQPPGTGKPIQGPT 262

Query: 209 MSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPP--------SPAYERG 260
            +PQ    +L       RP ++     RG +    P LP+ S PP         PA + G
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGES--VKPSLPSPSKPPIQQPTPGKPPAQQPG 320

Query: 261 LSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQ 320
                   A  P+  +     L+ +   +    +P       P + PL PA  P+     
Sbjct: 321 HEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGT--TKPPAQPLGPAKPPA----- 373

Query: 321 DLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPT 380
                +    E+P+     P ALA    +    A      QQ   A+     V   G P 
Sbjct: 374 -----QQTGSEKPSSEQPGPKALAQPPGVGKTPA------QQPGPAKPPTQQV---GTPK 419

Query: 381 PGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDK 440
           P    P L   + + GP    T+  +   G  G    Q AGPG+    +   T+  +   
Sbjct: 420 PLAQQPGLQSPAKAPGP----TKTPVQQPG-PGKIPAQQAGPGKTSAQQTGPTKPPS-QL 473

Query: 441 PLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQS-GPLTRSPQALSNGTKGTR 499
           P       +  G   P P  Q GS  P +    S +PP Q  GP   SPQ   +    T+
Sbjct: 474 PGPAKPPPQQPGPAKPPPQ-QPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS----TK 528

Query: 500 VPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPP 552
            P Q+  S      +P P    +  S        +G+PL PP   P    QPP
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSA-KQPP 580



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 69/290 (23%), Positives = 92/290 (31%), Gaps = 66/290 (22%)

Query: 371 GSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEA 430
           G+ +P  QP      P+   GS+    E  G +A     G+ G    Q  GP +      
Sbjct: 357 GTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV-GKTPAQQPGPAKPP---- 411

Query: 431 AATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQA 490
             TQ     KPL                A Q G  SPA A   +  P  Q GP     Q 
Sbjct: 412 --TQQVGTPKPL----------------AQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ 453

Query: 491 LSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQ 550
              G          + + P  P   LPG                  P  PP  QP P   
Sbjct: 454 AGPGKTSA------QQTGPTKPPSQLPG------------------PAKPPPQQPGPAKP 489

Query: 551 PPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQ 610
           PP      +P  A   +P S +   T  P  + G    A+ +    G       T+   Q
Sbjct: 490 PPQ-----QPGSA---KPPSQQPGSTKPPPQQPG---PAKPSPQQPGS------TKPPSQ 532

Query: 611 GPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660
            P   +  A +P    +K  ++   K  +  G G P      SPS    P
Sbjct: 533 QPGSAKPSAQQP--SPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP 580



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 137/650 (21%), Positives = 217/650 (33%), Gaps = 121/650 (18%)

Query: 116 ETLKEEVKRLRVLGDRPKPRAKE-----GTSDPPSPLLLPSPGGWKAITEKPPGGHEEAE 170
           +T + +  +L +  D  +P+ K+     G S  PS   LPSP   K   ++P  G   A+
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPS---LPSPS--KPPIQQPTPGKPPAQ 317

Query: 171 EDHQGVGLRGEEKPAGHR---TSPVAKIS---------PGATLPESR--------APDMS 210
           +        G  KP       T P+A+           PG T P ++        A    
Sbjct: 318 QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTG 377

Query: 211 PQRISNQLHGTIAVVRP-GSQACPADR-GPAN------GTPPPLPARSSPPSPAYERGLS 262
            ++ S++  G  A+ +P G    PA + GPA       GTP PL  +    SPA   G +
Sbjct: 378 SEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPT 437

Query: 263 LDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLH--LQSPHSSPLAPAAAPSDPRLQ 320
                +         +A        +      P  L    + P   P      P  P   
Sbjct: 438 KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSA 497

Query: 321 DLKAREAEAWEEPTELLG----LPSALAGMQDLRLEGALHLLLAQQQLRARARAG-SVRP 375
              +++  + + P +  G     P      +    +       AQQ   A+  A  S +P
Sbjct: 498 KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 557

Query: 376 RGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQD 435
             Q   G+ L    V   ++ P ++G    +    L          P +A        Q 
Sbjct: 558 VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICP--LCNTTELLLHVPEKANFNTCTECQT 615

Query: 436 -----CALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTR---- 486
                C  +    L+E       +        G L+P  +   SP+P  ++ P+T     
Sbjct: 616 TVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS---SPQPKLKTAPVTTTSAV 672

Query: 487 ---SPQALSNGTKGTRVPEQEEASTPMDPSRPLP--------GSQLSLSSPGSTEDEDTG 535
              SPQ      K    P+Q+ +  P +P +P P        GS  S  +    E +   
Sbjct: 673 SKSSPQPQQTSPKKDAAPKQDLSKAP-EPKKPPPLVKQPTLHGSP-SAKAKQPPEADSLS 730

Query: 536 RPLPPPHPQ-PPPHPQPPDLDGHPEPSKAEVLRPESDELDET------DTPGSEVGLSSQ 588
           +P PP  P  P    + P  D  P+  K  +++P +D +  +      D P S+V   SQ
Sbjct: 731 KPAPPKEPSVPSEQDKAPVADDKPKQPK--MVKPTTDLVSSSSATTKPDIPSSKV--QSQ 786

Query: 589 AEATTST---------------TGE-----------------------GPECICTQEHGQ 610
           AE  T+                TGE                       GP      +   
Sbjct: 787 AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQV 846

Query: 611 GPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660
            P +K++   +   K S KP        +   PG    A    P+P  SP
Sbjct: 847 DPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP 896



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 54/215 (25%), Positives = 77/215 (35%), Gaps = 30/215 (13%)

Query: 452 GQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPL---TRSPQALSNGTKGTRVPEQEEAST 508
           G+D  +  G   S+S         +PP    P+   T++PQ     T   ++P Q +AS 
Sbjct: 226 GRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQ-----TDHAKLPLQRDASR 280

Query: 509 PMDPSRPLP-GSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGH----PEPSKA 563
           P      +  G  +  S P          P  PP  QP P   P    GH    P P+K 
Sbjct: 281 PQTKQADIVRGESVKPSLPS---------PSKPPIQQPTPGKPPAQQPGHEKSQPGPAKP 331

Query: 564 EVLRPESDELDETDTPGSEVGLSSQAEATTSTTGE--GPECICTQEHGQGPPRKRKRASE 621
              +P          PG+ V    Q   TT    +  GP     Q+ G   P     + +
Sbjct: 332 PA-QPSGLTKPLAQQPGT-VKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP----SSEQ 385

Query: 622 PGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSP 656
           PG KA  +P    +      GP  P   +  +P P
Sbjct: 386 PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP 420



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 84/408 (20%), Positives = 135/408 (33%), Gaps = 42/408 (10%)

Query: 181  EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQ-LHGTIAVVRPGSQACPADRGPA 239
            +  P   +TSP    +P   L ++  P   P  +    LHG+ +          +   PA
Sbjct: 674  KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733

Query: 240  NGTPPPLPARS-----SPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
                P +P+       +   P   + +   + L +S  +    + P    +         
Sbjct: 734  PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 295  PLSLHLQSPHSS--PLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLR-L 351
            PL      P  S  P     +P D +     A +++    P    G  S   G + +  +
Sbjct: 794  PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHP----GPSSESKGQKQVDPV 849

Query: 352  EGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPS----LPVGSDSEGPENEGTRAALA 407
            +       AQ ++  +  A  + P+G PTP    P+    +P    S  P+ +  R +L 
Sbjct: 850  QKKEEPKKAQTKMSPKPDAKPM-PKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLN 908

Query: 408  AAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSP 467
               ++    +QP  P   Q T                S      GQ  P P  Q G  +P
Sbjct: 909  LGSITDAPKSQPTTP---QETVTGKLFGFGASIFSQASNLISTAGQ--PGPHSQSGPGAP 963

Query: 468  AAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPG 527
                 A  +PPT  GP   + QA     K   +P ++E   P          Q       
Sbjct: 964  MKQAPAPSQPPTSQGPPKSTGQAPPAPAKS--IPVKKETKAPAAEKLEPKAEQAPTVKRT 1021

Query: 528  STEDEDTGRPLPPPHPQPPPHPQPPDLDGHPE----PSKAEVL-RPES 570
             TE             +PPP      L   P+    P+K E   +PES
Sbjct: 1022 ETE------------KKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 119/569 (20%), Positives = 199/569 (34%), Gaps = 86/569 (15%)

Query: 105  TNEMNGLKEENETLKEEVKRLRVLGDRPKPRAK---EGTSDPPSPLLLPSPGGWKAITEK 161
            ++E  G K+ +   K+E  +       PKP AK   +G+  PP P   P+ G      ++
Sbjct: 837  SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR--PTAGQTVPTPQQ 894

Query: 162  PPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISP-----GATLPESRAPDMS----PQ 212
             P   E++      +G    + P    T+P   ++      GA++    +  +S    P 
Sbjct: 895  SPKPQEQSRRFSLNLGSI-TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPG 953

Query: 213  RISNQLHGTIAVVRPGSQACPADRGP--ANGTPPPLPARSSP-----PSPAYERGLSLDS 265
              S    G      P     P  +GP  + G  PP PA+S P      +PA E+   L+ 
Sbjct: 954  PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK---LEP 1010

Query: 266  FLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSP-HSSPLAPAAAPSDPRLQDLKA 324
                +     T    K  P  D   L   P    L +    SP   +  P      ++ +
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGS 1070

Query: 325  REAEAWEEPTELLGLPSALAGMQDLRLEGALH---LLLAQQQLRARARAGSVRPRGQPTP 381
            ++   +   TE       L G         +     L  Q Q     + G +R       
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPS 1130

Query: 382  GEMLPSLPVGSDSEGPEN-------------------------EGTRAALAAAGLSGGRH 416
            G     +PV ++S   +                          E  +  L+   +     
Sbjct: 1131 GPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVT 1190

Query: 417  T-QPAGPGRAQRTEAAATQDCALDKPLD-----LSEWGRARGQDTP------KPAGQHGS 464
            T Q     + ++ +A+A Q+    KPL      + E  + R ++        KP  +   
Sbjct: 1191 TDQKQEESKLEKDKASALQE---KKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKK 1247

Query: 465  LSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQ--EEASTPMDPSRPLP-GSQL 521
            L P A  +A   P  Q   L +S   ++      RV  +  +E   P      LP G+  
Sbjct: 1248 LLPEAKTSA---PEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQ 1304

Query: 522  SLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGS 581
            SL      ED+ T + +    PQPP   +P  ++   E ++ E    +  +   +  P S
Sbjct: 1305 SLPK----EDDKTTKTIKE-QPQPPCTAKPDQVEPGKEKTEKE---DDKSDTSSSQQPKS 1356

Query: 582  EVGLSS---QAEATTSTTGEGPECICTQE 607
              GLS     ++  +S+ GE P  I T E
Sbjct: 1357 PQGLSDTGYSSDGISSSLGEIPSLIPTDE 1385



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 37/140 (26%), Positives = 52/140 (37%), Gaps = 25/140 (17%)

Query: 500  VPEQEEASTPMDPS-----RPLPGSQLSLSSPG-------------STEDEDTGRPLPPP 541
            +P +E+ ST    S     +  P SQL   SP              S+  + + +P PPP
Sbjct: 2350 LPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPP 2409

Query: 542  HPQPPPHPQPPDLDGHPEP---SKAEVLRPESD----ELDETDTPGSEVGLSSQAEATTS 594
             P PPP P PP     P P   S    + P+          T TP  +   + +  A   
Sbjct: 2410 PPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLR 2469

Query: 595  TTGEGPECICTQEHGQGPPR 614
            + G     ICT      PP+
Sbjct: 2470 SNGLPVTRICTTAPPPVPPK 2489



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 10/74 (13%)

Query: 190  SPVAKISPGATLPESRAP-------DMSPQRISNQLHGTIAVVRPGSQACPADRGPANGT 242
            SP++ +SPG  L  +  P       D+SPQ++   LH  +A V P S         +   
Sbjct: 3625 SPISPLSPGKALESAFVPYEKPLPDDISPQKV---LHPDMAKVPPASPKTAKMMQRSMSD 3681

Query: 243  PPPLPARSSPPSPA 256
            P PL   +   S A
Sbjct: 3682 PKPLSPTADESSRA 3695


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 113/473 (23%), Positives = 168/473 (35%), Gaps = 63/473 (13%)

Query: 93  SHLQNLQRIFILTNEMN--GLKEENETLKEEV--KRLRVLGDRPKPRAKEGTSDPPSPLL 148
           S +  L  +  + N+ N   L  ++E  +EE   K+  V  ++ KP   EG   PP    
Sbjct: 158 SEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKP---EGIIKPPLQQQ 214

Query: 149 LPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPD 208
            P P     I ++   G +  ++D       G  K    +     K  P  T    + P 
Sbjct: 215 PPKP-----IPKQQGPGRDPLQQD-------GTPKSISSQQPEKIKSQPPGTGKPIQGPT 262

Query: 209 MSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPP--------SPAYERG 260
            +PQ    +L       RP ++     RG +    P LP+ S PP         PA + G
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGES--VKPSLPSPSKPPIQQPTPGKPPAQQPG 320

Query: 261 LSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQ 320
                   A  P+  +     L+ +   +    +P       P + PL PA  P+     
Sbjct: 321 HEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGT--TKPPAQPLGPAKPPA----- 373

Query: 321 DLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPT 380
                +    E+P+     P ALA    +    A      QQ   A+     V   G P 
Sbjct: 374 -----QQTGSEKPSSEQPGPKALAQPPGVGKTPA------QQPGPAKPPTQQV---GTPK 419

Query: 381 PGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDK 440
           P    P L   + + GP    T+  +   G  G    Q AGPG+    +   T+  +   
Sbjct: 420 PLAQQPGLQSPAKAPGP----TKTPVQQPG-PGKIPAQQAGPGKTSAQQTGPTKPPS-QL 473

Query: 441 PLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQS-GPLTRSPQALSNGTKGTR 499
           P       +  G   P P  Q GS  P +    S +PP Q  GP   SPQ   +    T+
Sbjct: 474 PGPAKPPPQQPGPAKPPPQ-QPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS----TK 528

Query: 500 VPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPP 552
            P Q+  S      +P P    +  S        +G+PL PP   P    QPP
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSA-KQPP 580



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 69/290 (23%), Positives = 92/290 (31%), Gaps = 66/290 (22%)

Query: 371 GSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEA 430
           G+ +P  QP      P+   GS+    E  G +A     G+ G    Q  GP +      
Sbjct: 357 GTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV-GKTPAQQPGPAKPP---- 411

Query: 431 AATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQA 490
             TQ     KPL                A Q G  SPA A   +  P  Q GP     Q 
Sbjct: 412 --TQQVGTPKPL----------------AQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ 453

Query: 491 LSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQ 550
              G          + + P  P   LPG                  P  PP  QP P   
Sbjct: 454 AGPGKTSA------QQTGPTKPPSQLPG------------------PAKPPPQQPGPAKP 489

Query: 551 PPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQ 610
           PP      +P  A   +P S +   T  P  + G    A+ +    G       T+   Q
Sbjct: 490 PPQ-----QPGSA---KPPSQQPGSTKPPPQQPG---PAKPSPQQPGS------TKPPSQ 532

Query: 611 GPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660
            P   +  A +P    +K  ++   K  +  G G P      SPS    P
Sbjct: 533 QPGSAKPSAQQP--SPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP 580



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 137/650 (21%), Positives = 217/650 (33%), Gaps = 121/650 (18%)

Query: 116 ETLKEEVKRLRVLGDRPKPRAKE-----GTSDPPSPLLLPSPGGWKAITEKPPGGHEEAE 170
           +T + +  +L +  D  +P+ K+     G S  PS   LPSP   K   ++P  G   A+
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPS---LPSPS--KPPIQQPTPGKPPAQ 317

Query: 171 EDHQGVGLRGEEKPAGHR---TSPVAKIS---------PGATLPESR--------APDMS 210
           +        G  KP       T P+A+           PG T P ++        A    
Sbjct: 318 QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTG 377

Query: 211 PQRISNQLHGTIAVVRP-GSQACPADR-GPAN------GTPPPLPARSSPPSPAYERGLS 262
            ++ S++  G  A+ +P G    PA + GPA       GTP PL  +    SPA   G +
Sbjct: 378 SEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPT 437

Query: 263 LDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLH--LQSPHSSPLAPAAAPSDPRLQ 320
                +         +A        +      P  L    + P   P      P  P   
Sbjct: 438 KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSA 497

Query: 321 DLKAREAEAWEEPTELLG----LPSALAGMQDLRLEGALHLLLAQQQLRARARAG-SVRP 375
              +++  + + P +  G     P      +    +       AQQ   A+  A  S +P
Sbjct: 498 KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 557

Query: 376 RGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQD 435
             Q   G+ L    V   ++ P ++G    +    L          P +A        Q 
Sbjct: 558 VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICP--LCNTTELLLHVPEKANFNTCTECQT 615

Query: 436 -----CALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTR---- 486
                C  +    L+E       +        G L+P  +   SP+P  ++ P+T     
Sbjct: 616 TVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS---SPQPKLKTAPVTTTSAV 672

Query: 487 ---SPQALSNGTKGTRVPEQEEASTPMDPSRPLP--------GSQLSLSSPGSTEDEDTG 535
              SPQ      K    P+Q+ +  P +P +P P        GS  S  +    E +   
Sbjct: 673 SKSSPQPQQTSPKKDAAPKQDLSKAP-EPKKPPPLVKQPTLHGSP-SAKAKQPPEADSLS 730

Query: 536 RPLPPPHPQ-PPPHPQPPDLDGHPEPSKAEVLRPESDELDET------DTPGSEVGLSSQ 588
           +P PP  P  P    + P  D  P+  K  +++P +D +  +      D P S+V   SQ
Sbjct: 731 KPAPPKEPSVPSEQDKAPVADDKPKQPK--MVKPTTDLVSSSSATTKPDIPSSKV--QSQ 786

Query: 589 AEATTST---------------TGE-----------------------GPECICTQEHGQ 610
           AE  T+                TGE                       GP      +   
Sbjct: 787 AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQV 846

Query: 611 GPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP 660
            P +K++   +   K S KP        +   PG    A    P+P  SP
Sbjct: 847 DPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP 896



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 54/215 (25%), Positives = 77/215 (35%), Gaps = 30/215 (13%)

Query: 452 GQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPL---TRSPQALSNGTKGTRVPEQEEAST 508
           G+D  +  G   S+S         +PP    P+   T++PQ     T   ++P Q +AS 
Sbjct: 226 GRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQ-----TDHAKLPLQRDASR 280

Query: 509 PMDPSRPLP-GSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGH----PEPSKA 563
           P      +  G  +  S P          P  PP  QP P   P    GH    P P+K 
Sbjct: 281 PQTKQADIVRGESVKPSLPS---------PSKPPIQQPTPGKPPAQQPGHEKSQPGPAKP 331

Query: 564 EVLRPESDELDETDTPGSEVGLSSQAEATTSTTGE--GPECICTQEHGQGPPRKRKRASE 621
              +P          PG+ V    Q   TT    +  GP     Q+ G   P     + +
Sbjct: 332 PA-QPSGLTKPLAQQPGT-VKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP----SSEQ 385

Query: 622 PGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSP 656
           PG KA  +P    +      GP  P   +  +P P
Sbjct: 386 PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP 420



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 84/408 (20%), Positives = 135/408 (33%), Gaps = 42/408 (10%)

Query: 181  EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQ-LHGTIAVVRPGSQACPADRGPA 239
            +  P   +TSP    +P   L ++  P   P  +    LHG+ +          +   PA
Sbjct: 674  KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733

Query: 240  NGTPPPLPARS-----SPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
                P +P+       +   P   + +   + L +S  +    + P    +         
Sbjct: 734  PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 295  PLSLHLQSPHSS--PLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLR-L 351
            PL      P  S  P     +P D +     A +++    P    G  S   G + +  +
Sbjct: 794  PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHP----GPSSESKGQKQVDPV 849

Query: 352  EGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPS----LPVGSDSEGPENEGTRAALA 407
            +       AQ ++  +  A  + P+G PTP    P+    +P    S  P+ +  R +L 
Sbjct: 850  QKKEEPKKAQTKMSPKPDAKPM-PKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLN 908

Query: 408  AAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSP 467
               ++    +QP  P   Q T                S      GQ  P P  Q G  +P
Sbjct: 909  LGSITDAPKSQPTTP---QETVTGKLFGFGASIFSQASNLISTAGQ--PGPHSQSGPGAP 963

Query: 468  AAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPG 527
                 A  +PPT  GP   + QA     K   +P ++E   P          Q       
Sbjct: 964  MKQAPAPSQPPTSQGPPKSTGQAPPAPAKS--IPVKKETKAPAAEKLEPKAEQAPTVKRT 1021

Query: 528  STEDEDTGRPLPPPHPQPPPHPQPPDLDGHPE----PSKAEVL-RPES 570
             TE             +PPP      L   P+    P+K E   +PES
Sbjct: 1022 ETE------------KKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 119/569 (20%), Positives = 199/569 (34%), Gaps = 86/569 (15%)

Query: 105  TNEMNGLKEENETLKEEVKRLRVLGDRPKPRAK---EGTSDPPSPLLLPSPGGWKAITEK 161
            ++E  G K+ +   K+E  +       PKP AK   +G+  PP P   P+ G      ++
Sbjct: 837  SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR--PTAGQTVPTPQQ 894

Query: 162  PPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISP-----GATLPESRAPDMS----PQ 212
             P   E++      +G    + P    T+P   ++      GA++    +  +S    P 
Sbjct: 895  SPKPQEQSRRFSLNLGSI-TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPG 953

Query: 213  RISNQLHGTIAVVRPGSQACPADRGP--ANGTPPPLPARSSP-----PSPAYERGLSLDS 265
              S    G      P     P  +GP  + G  PP PA+S P      +PA E+   L+ 
Sbjct: 954  PHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK---LEP 1010

Query: 266  FLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSP-HSSPLAPAAAPSDPRLQDLKA 324
                +     T    K  P  D   L   P    L +    SP   +  P      ++ +
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGS 1070

Query: 325  REAEAWEEPTELLGLPSALAGMQDLRLEGALH---LLLAQQQLRARARAGSVRPRGQPTP 381
            ++   +   TE       L G         +     L  Q Q     + G +R       
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPS 1130

Query: 382  GEMLPSLPVGSDSEGPEN-------------------------EGTRAALAAAGLSGGRH 416
            G     +PV ++S   +                          E  +  L+   +     
Sbjct: 1131 GPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVT 1190

Query: 417  T-QPAGPGRAQRTEAAATQDCALDKPLD-----LSEWGRARGQDTP------KPAGQHGS 464
            T Q     + ++ +A+A Q+    KPL      + E  + R ++        KP  +   
Sbjct: 1191 TDQKQEESKLEKDKASALQE---KKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKK 1247

Query: 465  LSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQ--EEASTPMDPSRPLP-GSQL 521
            L P A  +A   P  Q   L +S   ++      RV  +  +E   P      LP G+  
Sbjct: 1248 LLPEAKTSA---PEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQ 1304

Query: 522  SLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGS 581
            SL      ED+ T + +    PQPP   +P  ++   E ++ E    +  +   +  P S
Sbjct: 1305 SLPK----EDDKTTKTIKE-QPQPPCTAKPDQVEPGKEKTEKE---DDKSDTSSSQQPKS 1356

Query: 582  EVGLSS---QAEATTSTTGEGPECICTQE 607
              GLS     ++  +S+ GE P  I T E
Sbjct: 1357 PQGLSDTGYSSDGISSSLGEIPSLIPTDE 1385



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 37/140 (26%), Positives = 52/140 (37%), Gaps = 25/140 (17%)

Query: 500  VPEQEEASTPMDPS-----RPLPGSQLSLSSPG-------------STEDEDTGRPLPPP 541
            +P +E+ ST    S     +  P SQL   SP              S+  + + +P PPP
Sbjct: 2350 LPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPP 2409

Query: 542  HPQPPPHPQPPDLDGHPEP---SKAEVLRPESD----ELDETDTPGSEVGLSSQAEATTS 594
             P PPP P PP     P P   S    + P+          T TP  +   + +  A   
Sbjct: 2410 PPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLR 2469

Query: 595  TTGEGPECICTQEHGQGPPR 614
            + G     ICT      PP+
Sbjct: 2470 SNGLPVTRICTTAPPPVPPK 2489



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 10/74 (13%)

Query: 190  SPVAKISPGATLPESRAP-------DMSPQRISNQLHGTIAVVRPGSQACPADRGPANGT 242
            SP++ +SPG  L  +  P       D+SPQ++   LH  +A V P S         +   
Sbjct: 3625 SPISPLSPGKALESAFVPYEKPLPDDISPQKV---LHPDMAKVPPASPKTAKMMQRSMSD 3681

Query: 243  PPPLPARSSPPSPA 256
            P PL   +   S A
Sbjct: 3682 PKPLSPTADESSRA 3695


>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
          Length = 962

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 137/558 (24%), Positives = 189/558 (33%), Gaps = 107/558 (19%)

Query: 142 DPPSPLL---LPSPGGWKAITEKPPGGH-EEAEEDHQGVGLRGEEK--------PAGHRT 189
           +PPSP      P P G K   E PP G    A +  + V    E+         P G  T
Sbjct: 353 EPPSPPEGPPNPGPDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPTAIPEGDTT 412

Query: 190 SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPAR 249
            P  +  P AT     A D   + +  +   T  V+         ++GP    P P P R
Sbjct: 413 PP--ETDPAATSEAPSARDGPERSVPKEAEPTPPVLPD------EEKGPPG--PAPEPER 462

Query: 250 SSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLA 309
            +   P  ERG   +     + PS     AP  SP   + CL +RP +       S PLA
Sbjct: 463 EAETEP--ERGAGTEPERIGTEPST----APAPSPPAPKSCLKHRPAAASEGPAASPPLA 516

Query: 310 PAAAPS-DPRLQDL----------KAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLL 358
            A +P  +P    L          KA  AEA     E    P   A      L GA    
Sbjct: 517 AAESPPVEPGPGSLDAEAAAPERPKAERAEAPPAGAE-RAAPERKAERGGAELRGAKKFS 575

Query: 359 LAQQQLRARARAGSVRP--------------------------RGQPTPGEMLPSLPVGS 392
           ++    RAR R G  RP                          +G P P    P  P   
Sbjct: 576 VS--SCRARPRPGVSRPLERASGRLPLARSGPVWRSEAALDDLQGLPEPQHAKPG-PRKL 632

Query: 393 DSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDK---PLDLS---- 445
              GP++ G RAA + AG         A PG  +   AA     + D+   P+ L     
Sbjct: 633 AERGPQDSGDRAA-SPAGPRKSPQEAAAAPGTREPCPAAQEPAPSEDRNPFPVKLRSTSL 691

Query: 446 --EWGRARGQDTPKPAGQHGSLSPAAAHTASPEP---PTQSGPLTRSPQALSNGTKGTRV 500
             ++     Q+          +    + T  P+    P  + P  R  +A S+  KG   
Sbjct: 692 SLKYRDGASQEVKGVKRYSAEVRLERSLTVLPKEEKCPLGTAPALRGTRAPSDQGKGKAR 751

Query: 501 PEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEP 560
           P +  +S P  P +PL  S                     PH   PP   P + +   EP
Sbjct: 752 PPEPLSSKPPLPRKPLLQS------------------FTLPHQPAPPDAGPGEREPRKEP 793

Query: 561 SKAEVLRPESDELDETDTPGSEVGLSSQAEAT----TSTTGEGPECICTQEHGQGPPRKR 616
             AE  RP      E   P +  G  +  +      T T  +    +    + +  P  R
Sbjct: 794 RTAE-KRPLRRGA-EKSLPPAATGPGADGQPAPPWITVTRQKRRGTLDQPPNQEDKPGAR 851

Query: 617 KRASEPGDKASKKPSRGR 634
              SEPG K +K P RG+
Sbjct: 852 TLKSEPG-KQAKVPERGQ 868



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 114/456 (25%), Positives = 154/456 (33%), Gaps = 45/456 (9%)

Query: 183 KPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVV---RP--GSQACPADRG 237
           KP   R+S + ++S  A          +P+   N+    + V    RP  G Q    DRG
Sbjct: 231 KPRNQRSSKMRRLSSRAQSESLSDLTCTPEEEENEEKPLLEVSPEERPSSGQQDVAPDRG 290

Query: 238 PANGTPPPLPARSSPPSPAYERGLSL--DSFLRAS-RPSAMTHEAPKLSPKVDRLCLLNR 294
           P  G P PLP    PP  A  R   L   S L AS     +  E P   P    L     
Sbjct: 291 PEPGPPAPLP----PPGGARARRARLQHSSALTASVEEGGVPGEDPSSRPATPELAEPES 346

Query: 295 PLSLHLQSPHSSPLAPAAAPSDPRLQDLKARE----AEAWEEPTELLGLPSALAGMQDLR 350
             +L ++ P S P  P     D   QD +A      A A ++  E++  P  +A      
Sbjct: 347 APTLRVEPP-SPPEGPPNPGPDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPTA 405

Query: 351 L-EGALHLLLAQQQLRARARAGSVRPRGQ-PTPGEMLPSLPVGSDSE----GPENEGTRA 404
           + EG       +    A + A S R   +   P E  P+ PV  D E    GP  E  R 
Sbjct: 406 IPEG--DTTPPETDPAATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPERE 463

Query: 405 ALAAAGLSGGRHTQPAG--PGRAQRTEAAATQDCALDKPLDLSEWGRA----RGQDTPKP 458
           A        G   +  G  P  A      A + C   +P   SE   A       ++P  
Sbjct: 464 AETEPERGAGTEPERIGTEPSTAPAPSPPAPKSCLKHRPAAASEGPAASPPLAAAESPPV 523

Query: 459 AGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTK---GTRVPEQEEASTPMDPSRP 515
               GSL   AA    P+      P   + +A         G  +   ++ S     +RP
Sbjct: 524 EPGPGSLDAEAAAPERPKAERAEAPPAGAERAAPERKAERGGAELRGAKKFSVSSCRARP 583

Query: 516 LPGSQLSLSSPGSTEDEDTGR-PLPPPHPQPPPHPQPPDLDGHPEPSKAEV---LRPESD 571
            PG    L       +  +GR PL    P         DL G PEP  A+       E  
Sbjct: 584 RPGVSRPL-------ERASGRLPLARSGPVWRSEAALDDLQGLPEPQHAKPGPRKLAERG 636

Query: 572 ELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQE 607
             D  D   S  G     +   +  G    C   QE
Sbjct: 637 PQDSGDRAASPAGPRKSPQEAAAAPGTREPCPAAQE 672



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 56/224 (25%), Positives = 81/224 (36%), Gaps = 53/224 (23%)

Query: 474 SPEPPTQSGPLTRS----PQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGST 529
           +P PP       R+      AL+   +   VP ++ +S P  P    P            
Sbjct: 297 APLPPPGGARARRARLQHSSALTASVEEGGVPGEDPSSRPATPELAEP------------ 344

Query: 530 EDEDTGRPLPPPHPQPPPHPQPP--DLDGHPEPS--------KAE--------VLRPESD 571
           E   T R  PP  P+ PP+P P     DG   P+        KAE        V  P   
Sbjct: 345 ESAPTLRVEPPSPPEGPPNPGPDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPT 404

Query: 572 ELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQE---------------HGQGPPRKR 616
            + E DT   E   ++ +EA ++   +GPE    +E                G  P  +R
Sbjct: 405 AIPEGDTTPPETDPAATSEAPSAR--DGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPER 462

Query: 617 KRASEPGDKASKKPSR-GRRKLTA-TEGPGSPRDAEDHSPSPNS 658
           +  +EP   A  +P R G    TA    P +P+    H P+  S
Sbjct: 463 EAETEPERGAGTEPERIGTEPSTAPAPSPPAPKSCLKHRPAAAS 506


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 100/517 (19%), Positives = 183/517 (35%), Gaps = 58/517 (11%)

Query: 180  GEEKPAGHRTSPVAKIS---------PGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQ 230
            G  +P G   +P++ +          PG  +P+ +   +      +++   +  +  G+ 
Sbjct: 2134 GMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTA 2193

Query: 231  ACPADRGPA------NGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLS- 283
              P     A      +  P P+P  S   +PA     +L S + A+  +AM   + +   
Sbjct: 2194 RPPPSMSAAGLAARMSQVPAPVPLMSLRTAPA----ANLASRIPAASAAAMNLASARTPA 2249

Query: 284  -PKVDRLCLLNRPLS---LHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGL 339
             P    L     P +   ++L SP ++    A   +DPR     A        P  L  L
Sbjct: 2250 IPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAAL 2309

Query: 340  PSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPEN 399
                +G        A +   + +  +A A A  V PR       +  ++     +     
Sbjct: 2310 SLTGSGTPPT----AANYPSSSRTPQAPASANLVGPRSAHATAPV--NIAGSRTAAALAP 2363

Query: 400  EGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDK-----PLDLSEWGRARGQD 454
                +A  A  LSG   T P  P  A    +  T    LD+     P       R   + 
Sbjct: 2364 ASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSER 2423

Query: 455  TPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSR 514
             P P+ + G      A + S  PP Q  P +  P A S+ ++          +TP+  S+
Sbjct: 2424 APSPSSRMGQ-----APSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQ-----TTPVAGSQ 2473

Query: 515  PLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELD 574
             L    ++ ++  S  D +    +P P        +PP   G  +PS    L+P  +   
Sbjct: 2474 SLSSGAVATTT-SSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRS 2532

Query: 575  ETDTPGSEVGLSSQAEATTSTTGEGPECICTQ------------EHGQGPPRKRKRASEP 622
             + +  S    SS + +++S++  G     ++            +    P    K A   
Sbjct: 2533 SSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVRE 2592

Query: 623  GDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSS 659
            G      P++ +R+ +++    S   +   S S +SS
Sbjct: 2593 GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSS 2629



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 125/555 (22%), Positives = 191/555 (34%), Gaps = 73/555 (13%)

Query: 172  DHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAP-DMSPQRISNQLHGTIAVV----- 225
            DHQ   +     P  H  S +A      +L  +R P  MS   ++ ++    A V     
Sbjct: 2166 DHQRTSV-----PENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSL 2220

Query: 226  RPGSQACPADRGPA---------NGTPPPLPAR---SSPPSPAYERGLSLDSFLRASRPS 273
            R    A  A R PA         +   P +P     +   +PA    ++L S   A  PS
Sbjct: 2221 RTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPS 2280

Query: 274  AMTHEAPKL--SPKVDRLCLLNRPLSLHLQSPHSSPLAPAAA--------PSDPRLQDLK 323
            A+    P+   +P V+ L     P +L   S   S   P AA        P  P   +L 
Sbjct: 2281 AVNLADPRTPTAPAVN-LAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLV 2339

Query: 324  AREAEAWEEPTELLGLPSALA----GMQDLRLEGAL---HLLLAQQQLRARAR-AGSVRP 375
               +     P  + G  +A A     +   R+  AL   +L   +  L A  R +G   P
Sbjct: 2340 GPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSP 2399

Query: 376  ----RGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGP---GRAQRT 428
                R +       PS    +    P          +  L      QP  P     + ++
Sbjct: 2400 PLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQS 2459

Query: 429  EAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSL----SPAAAHTASPEPPTQSGPL 484
                 Q   +     LS    A    T   AG H  +    +P   H+   EPP  +G  
Sbjct: 2460 RCLIAQTTPVAGSQSLSSGAVAT---TTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQ 2516

Query: 485  TRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPH-- 542
              S  A     K  R      +S+    S     S  S S   S++ E +  P+ P    
Sbjct: 2517 QPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVAL 2576

Query: 543  ---PQPPPHPQPPDLDGHP-EPSKAE-VLRPESDELDETDTPGSEVGLSSQAEATTSTTG 597
               P P P P+    +G P EP+ A+   R  S     + +  S    SS + +++S++ 
Sbjct: 2577 KRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2636

Query: 598  EGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGP-GSPRDA------- 649
                   +      P +   +A  P   + KKP  G R+  +   P  S RD+       
Sbjct: 2637 SSSSSSSSSSSSPSPAKPGPQAL-PKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP 2695

Query: 650  -EDHSPSPNSSPWEE 663
             E   PSP  SP ++
Sbjct: 2696 VERRRPSPQPSPRDQ 2710



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 111/523 (21%), Positives = 171/523 (32%), Gaps = 74/523 (14%)

Query: 131 RPKPRAKEGTSDP----PSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAG 186
           RP P  +  ++ P    P+PLL    GG        P   E      +    R    P  
Sbjct: 349 RPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKS 408

Query: 187 HRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPL 246
               P +  S      ES  P   P ++S                  A   P +  P P 
Sbjct: 409 PEKLPQSSSS------ESSPPSPQPTKVSRH----------------ASSSPESPKPAPA 446

Query: 247 PAR-----SSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQ 301
           P       SSP S     G       RA R  + +H   +   +        R  S   +
Sbjct: 447 PGSHREISSSPTSKNRSHG-------RAKRDKSHSHTPSRRMGRSRSPATAKRGRS-RSR 498

Query: 302 SPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQ 361
           +P     + + +P     Q  ++R A+ W         P      +  +  G       Q
Sbjct: 499 TPTKRGHSRSRSP-----QWRRSRSAQRWGRSRS----PQRRGRSRSPQRPGWSRSRNTQ 549

Query: 362 QQLRAR-ARAGSVRPRGQPTPGEMLPSLPVG---SDSEGPENEGTRAALAAAGLSGGRHT 417
           ++ R+R AR G    R   T G      P     S S  P    +R+       S  R  
Sbjct: 550 RRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSR-- 607

Query: 418 QPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEP 477
            PA  GR+ R+   A +      P+      R+R +   + +G+  S +PA    +    
Sbjct: 608 TPARRGRS-RSRTPARRRSRTRSPVRR----RSRSRSPARRSGRSRSRTPARRGRSRSRT 662

Query: 478 PTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGR- 536
           P + G       A  +G   +R P +   S    P R    S+ SL   G +      R 
Sbjct: 663 PARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSR-SLVRRGRSHSRTPQRR 721

Query: 537 ----PLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEAT 592
                      +     +    +  PE  K+ +    S  L    +P S+    S+    
Sbjct: 722 GRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSL---SSPRSKA--KSRLSLR 776

Query: 593 TSTTGEGPECICTQEHGQGPPRK-RKRASEPGDKASKKPSRGR 634
            S +G  P   C ++  Q PPR+ R  +S+P  K+   P R R
Sbjct: 777 RSLSGSSP---CPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSR 816



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 120/589 (20%), Positives = 180/589 (30%), Gaps = 88/589 (14%)

Query: 131  RPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPG-----GHEEAEEDHQ----------- 174
            +P   ++  +S P SP   P+PG  + I+  P       G  + ++ H            
Sbjct: 426  QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485

Query: 175  --GVGLRGEEKPA-----GH--------RTSPVAKISPGATLPESRAPDMSPQRI----- 214
                  RG  +       GH        R S  A+    +  P+ R    SPQR      
Sbjct: 486  SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRS 545

Query: 215  -SNQLHGTIAVVRPGSQ--ACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASR 271
             + Q  G     R G      PA RG +    P    RS   +PA  R  S     R SR
Sbjct: 546  RNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSR 605

Query: 272  PSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWE 331
                       S    R     R          S       + S    +  ++R      
Sbjct: 606  SRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPAR 665

Query: 332  EPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVG 391
                    P+  +G    R         ++   R R+R+ S+  RG+            G
Sbjct: 666  RGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSG 725

Query: 392  SDSE----------------GPENEGTR-AALAAAGLSGGRH--------------TQPA 420
            S SE                 PE + +R ++  +  LS  R               + P 
Sbjct: 726  SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPC 785

Query: 421  GPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQ 480
               ++Q     +    +  K    +   R+R   +P P  +  + S  +  ++SP P  +
Sbjct: 786  PKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK 845

Query: 481  SGPLTR-----SPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTG 535
            SG   R     SPQA        R    E +  P   SR       S SSP   +     
Sbjct: 846  SGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPP 905

Query: 536  RPLPPPHPQPPP------HPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLS--- 586
            R  P     P P       P+     G   PS + V    +     + +P S V      
Sbjct: 906  RQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLP 965

Query: 587  --SQAEATTSTTGEGPECICTQEHGQ--GPPRKRKRASEPGDKASKKPS 631
              S + +++  T   PE    Q H     P  K K  + PG   S   S
Sbjct: 966  RYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKS 1014



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 54/268 (20%), Positives = 89/268 (33%), Gaps = 22/268 (8%)

Query: 391  GSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRA--QRTEAAATQDCALDKPLDLSEWG 448
            GS+S   +    R  L     SG        P  +  +R+E+ ++ D        L +  
Sbjct: 1518 GSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQ-- 1575

Query: 449  RARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEAST 508
            R+R   +P+       LSP  + + S      S  +   P+A      G+    + +A  
Sbjct: 1576 RSRSGSSPE-VDSKSRLSPRRSRSGS------SPEVKDKPRAAPRAQSGSDSSPEPKAPA 1628

Query: 509  PMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRP 568
            P    R LP    S SS         G       P+ PP  +         P      R 
Sbjct: 1629 P----RALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRT 1684

Query: 569  ESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASK 628
                     +P  E+   ++    + +    PE        + PPR R+  S    + ++
Sbjct: 1685 PPRRRSSRSSP--ELTRKARLSRRSRSASSSPET-----RSRTPPRHRRSPSVSSPEPAE 1737

Query: 629  KPSRGRRKLTATEGPGSPRDAEDHSPSP 656
            K    RR+ +A+            SPSP
Sbjct: 1738 KSRSSRRRRSASSPRTKTTSRRGRSPSP 1765



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 103/514 (20%), Positives = 166/514 (32%), Gaps = 92/514 (17%)

Query: 139  GTSDPPSPLLLPSPGGW-----KAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVA 193
            G+  PP+    PS          A    P   H  A  +  G        PA   ++ +A
Sbjct: 2313 GSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMA 2372

Query: 194  KISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPP 253
                GA L   R P  + +R+S +                        T PPL  R+   
Sbjct: 2373 PALSGANLTSPRVPLSAYERVSGR------------------------TSPPLLDRARSR 2408

Query: 254  SPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAA 313
            +P      S  +  RA  PS+   +AP  S        L  P     +SP      P+A 
Sbjct: 2409 TPPSAPSQSRMTSERAPSPSSRMGQAPSQS--------LLPPAQDQPRSP-----VPSAF 2455

Query: 314  PSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSV 373
                R                 L+   + +AG Q L   GA+    A     A    G +
Sbjct: 2456 SDQSRC----------------LIAQTTPVAGSQSLS-SGAV----ATTTSSAGDHNGML 2494

Query: 374  RPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAAT 433
                 P PG  +P   VG   E P + G +   A A L   +  + +    +  + ++++
Sbjct: 2495 ---SVPAPG--VPHSDVG---EPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSS 2546

Query: 434  QDCALDKPLDLSEWGRARGQDTPKPAG----QHGSLSPAAAHTASPEPPTQSGPLTRSPQ 489
               +       S    + G   P        +  S +PA         P +  P  R  +
Sbjct: 2547 SSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRR 2606

Query: 490  ALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHP 549
            + S+ +  +       +S+    S     S  S SS  S+      +P P   P+P    
Sbjct: 2607 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPK 2666

Query: 550  QPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHG 609
            +PP     P   ++   R   D L ++ +        S  E    +    P     ++  
Sbjct: 2667 KPP-----PGERRSRSPRKPIDSLRDSRSLS-----YSPVERRRPSPQPSP-----RDQQ 2711

Query: 610  QGPPRKRKRASEPGDKASKKPSRGRRKLTATEGP 643
                 +  R  + GD  S+ PS  RR+ T +  P
Sbjct: 2712 SSSSERGSRRGQRGD--SRSPSHKRRRETPSPRP 2743



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 56/259 (21%), Positives = 88/259 (33%), Gaps = 16/259 (6%)

Query: 417  TQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPE 476
            T P+   + Q T ++      L  P  + + G +  Q    P       +P+   ++S  
Sbjct: 1365 TDPSLDMKEQSTRSSGHSSSELS-PDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSAS 1423

Query: 477  PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGR 536
             P     L R+P   S       + +     +    S   PG +    +P     E    
Sbjct: 1424 SPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSS 1483

Query: 537  PLPPPHPQPPP----HPQPPDLDGHPEPSKAEVLRPES--DELDETDTP-------GSEV 583
            P P   PQ P      P  P+L+      + E    ES  D+     TP       GS  
Sbjct: 1484 PEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQ 1543

Query: 584  GLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRA--SEPGDKASKKPSRGRRKLTATE 641
             L  +  A+     E      ++   + P R+R R+  S   D  S+   R  R  ++ E
Sbjct: 1544 ELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPE 1603

Query: 642  GPGSPRDAEDHSPSPNSSP 660
                PR A       +SSP
Sbjct: 1604 VKDKPRAAPRAQSGSDSSP 1622



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 74/322 (22%), Positives = 111/322 (34%), Gaps = 60/322 (18%)

Query: 365 RARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGR 424
           R+R+R+ + +       G   PS   G   EG       A  +  G +  +  +P+ P  
Sbjct: 276 RSRSRSAAAKTHTTALAGRS-PSPASGRRGEGD------APFSEPGTTSTQ--RPSSPET 326

Query: 425 AQRTEAAATQDCALDKPL----------DLSEWGRARGQDTPKPAGQHG-SLSPAAAHTA 473
           A +  ++  +D   DK            + S  G      TP  A +HG S  P A    
Sbjct: 327 ATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPL 386

Query: 474 SPEP--------PTQSGPLTRSPQALSNGTKGTRVPEQEE--------ASTPMDPS-RPL 516
           S EP        PT+     +SP+ L   +     P   +        +S+P  P   P 
Sbjct: 387 SQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPA 446

Query: 517 PGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDET 576
           PGS   +SS  ++++   GR       +   H   P        S A   R  S     T
Sbjct: 447 PGSHREISSSPTSKNRSHGRA-----KRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPT 501

Query: 577 DTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQG-PPRKRKRASEPGDKASKKPSRGRR 635
              G     S Q   + S           Q  G+   P++R R+  P     ++P   R 
Sbjct: 502 KR-GHSRSRSPQWRRSRS----------AQRWGRSRSPQRRGRSRSP-----QRPGWSRS 545

Query: 636 KLTATEGPG-SPRDAEDHSPSP 656
           + T   G   S R    HS SP
Sbjct: 546 RNTQRRGRSRSARRGRSHSRSP 567



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 120/641 (18%), Positives = 209/641 (32%), Gaps = 119/641 (18%)

Query: 83   ARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRVL-GDRPKPRAKEGTS 141
            +R  Q+   S+    +++  I +     L       K  +   R L G  P P+ K  T 
Sbjct: 734  SRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTP 793

Query: 142  DPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGA-- 199
               S      P   KA +  PP     +         +   + +   +SP  K+  G   
Sbjct: 794  PRRSRSGSSQP---KAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPP 850

Query: 200  -----TLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPS 254
                 T P++    ++PQR S           P  ++    R   +G+ PP    S+PP 
Sbjct: 851  RQGSITSPQANEQSVTPQRRSCFESSP----DPELKSRTPSRHSCSGSSPPRVKSSTPPR 906

Query: 255  PAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSP----------- 303
             +  R  S    ++A         +   SP   R+     P      SP           
Sbjct: 907  QSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPR 966

Query: 304  ----------------------HSSPLAP-----AAAPSDPRLQDLKAREAEAWEEPTEL 336
                                  HS  ++P     A  P  P L   K+   +   + + +
Sbjct: 967  YSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLV 1026

Query: 337  LGLPSAL---AGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSD 393
               P +L   AG++     G  +  ++  QL+ ++         Q +P          SD
Sbjct: 1027 QSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQS---------QTSPDHR-------SD 1070

Query: 394  SEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQ 453
            +  PE   + +   +  L     T P G GR++   ++   + A   P+      + RG+
Sbjct: 1071 TSSPEVRQSHS--ESPSLQSKSQTSPKG-GRSR--SSSPVTELASRSPI-----RQDRGE 1120

Query: 454  DTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPS 513
             +  P  + G +SP  +   S    + S P   S   L      T   +++ A  P + +
Sbjct: 1121 FSASPMLKSG-MSPEQSRFQS---DSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDA 1176

Query: 514  RPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDE- 572
               P  Q    SP   +D      +     + PP  +       PE  +     P S + 
Sbjct: 1177 TASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPR-ERSGAGSSPETKEQNSALPTSSQD 1235

Query: 573  ------LDETDTPGSEV--GLSSQ-AEATTSTTGEGPECICTQEHGQGPPRKRKRASEPG 623
                  +++++ P  ++   LSS+  E +TS     PE                    P 
Sbjct: 1236 EELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEV----------------EERPA 1279

Query: 624  DKASKKPSRGRRKLTATEGP------GSPRDAEDHSPSPNS 658
               +   S+ +  L A E P      G P  + +H    NS
Sbjct: 1280 VSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNS 1320


>gi|188536004 zinc finger protein 469 [Homo sapiens]
          Length = 3925

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 122/526 (23%), Positives = 178/526 (33%), Gaps = 121/526 (23%)

Query: 130  DRPKPRAKEGT-SDPPSPLLL--------PSPGGWKAITEKP--PGGHEEAEEDHQGVGL 178
            DRP PR      S+   P LL         +  GW    E+P  P  H           +
Sbjct: 3461 DRPPPRGSSPILSEGSLPALLHLCSEVAPSTTKGWPETLERPVDPVTHP----------I 3510

Query: 179  RGEEKPAGHRTSPVAKISP-GATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRG 237
            RG E P+ H+  P   +SP  A L + R            L G  A+ RP ++A P   G
Sbjct: 3511 RGCELPSNHQECPPPSLSPFPAALADGRG--------DCALDG--ALERPENEASPGSPG 3560

Query: 238  PANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLS 297
            P       LP  +S P P   RG   +      + + +     + +P     C  +    
Sbjct: 3561 PL--LQQALPLGASLPRPG-ARGQDAEG-----KRAPLVFSGKRRAPGARGRCAPDHFQE 3612

Query: 298  LHL----QSPHSSPLAPAAAP---------SDPRLQDLKAREAEAWEEPTELLGLPSALA 344
             HL    +   SS +     P         + P      +++  A   P++ L  P    
Sbjct: 3613 DHLLQKEKEVSSSHMVSEGGPRGTFHKGSATKPAGCQSSSKDRSAASTPSKALKFP---- 3668

Query: 345  GMQDLRLEGALHLLLAQQQLRARARAGSVRPR--GQPTPGEMLPSLPVGSDSEGPENEGT 402
                               +  R   GS+ P    + T   M P+ P      GP ++G+
Sbjct: 3669 -------------------VHPRKAVGSLAPGELARGTENGMKPATPKAKP--GPSSQGS 3707

Query: 403  RAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDT-----PK 457
             +        GG   QPA  G+ Q   A      +        E   AR Q       P+
Sbjct: 3708 GSPRPGTKTGGGSQPQPAS-GQLQSETATTPAKPSFPSRSPAPERLPARAQAKSCTKGPR 3766

Query: 458  PAGQ---HGSLSPAAAHTASPEP-------PTQSGPLTRSPQALSNGTKGTRVPEQEEAS 507
             AG+   HGSL P     +S +        P +S  +    +A S   K  R P ++   
Sbjct: 3767 EAGEQGPHGSLGPKEKGESSTKRKKGQVPGPARSESVGSFGRAPSAPDKPPRTPRKQATP 3826

Query: 508  TPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQ---PPPHPQPPDLDGHPEPSKAE 564
            + + P++P P SQ               +P PPP  Q    P H Q  D  G   P    
Sbjct: 3827 SRVLPTKPKPNSQ--------------NKPRPPPSEQRKAEPGHTQRKDRLGKAFPQGRP 3872

Query: 565  VLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQ 610
            +LRP           G+ V  +  AE  T  T E    + +Q  GQ
Sbjct: 3873 LLRPPK--------RGTAVHGAEPAEPHTHRTAEAQSDLLSQLFGQ 3910



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 143/555 (25%), Positives = 191/555 (34%), Gaps = 106/555 (19%)

Query: 112 KEENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKP--PGGHEEA 169
           + E +   EE+   R   + P        + P +    P+PG  ++    P  PG + E 
Sbjct: 168 RTEAQPAAEELGFHRCFQEPPSSFTSTNYTSPSATPRPPAPGPPQSRGTSPLQPGSYPEY 227

Query: 170 EEDHQGVGLRGEEK--PAGHRTSPVAKISPGATLPESRAPDMSPQRISNQ-----LHGTI 222
           +           E   P  +   P A+  P   +P+   P  SP+ +S Q     LHG  
Sbjct: 228 QASGADSWPPAAENSFPGANFGVPPAEPEP---IPKGSRPGGSPRGVSFQFPFPALHGAS 284

Query: 223 AVVRPGSQACPA-DRGP---------------ANGTPP--PLPARSSP-PSPAYER---G 260
               P   A  A   GP               A GT P  PLP + +P P P Y+    G
Sbjct: 285 TKPFPADVAGHAFTNGPLVFAFHQPQGAWPEEAVGTGPAYPLPTQPAPSPLPCYQGQPGG 344

Query: 261 LSLDSFLRASRPS-AMTHEAPKLSPKVDRL------CLLNRPLSLH-----LQSPHSS-- 306
           L+  S L  +  S    H AP+  P  D L       L  RP S        + P SS  
Sbjct: 345 LNRHSDLSGALSSPGAAHSAPR--PFSDSLHKSLTKILPERPPSAQDGLGSTRGPPSSLP 402

Query: 307 --------------------PLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSA--LA 344
                               P    AAP  P      AR  + W+        P    LA
Sbjct: 403 QRHFPGQAYRASGVDTSPGPPDTELAAPGPP-----PARLPQLWDPTAAPYPTPPGGPLA 457

Query: 345 GMQDLRLEG----ALHLLLAQQQLRARARAGSVRPRGQPTPG--EMLPSLPVGSDSEGPE 398
             + +   G       L L Q    A      V P  +P+P   EML  LP  +   GPE
Sbjct: 458 ATRSMFFNGQPSPGQRLCLPQS---APLPWPQVLPTARPSPHGMEMLSRLPFPAG--GPE 512

Query: 399 NEG-TRAALAAAGLSGG-RHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTP 456
            +G ++ AL  AG + G R   PA       + A  T +   D       +G A+ Q +P
Sbjct: 513 WQGGSQGALGTAGKTPGPREKLPAVRSSQGGSPALFTYNGMTDPGAQPLFFGVAQPQVSP 572

Query: 457 KPAGQHG--SLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSR 514
                HG  SL P     ASP       P T +    +  T  +  P     + P     
Sbjct: 573 -----HGTPSLPPPRVVGASPSESPLPSPATNT----AGSTCSSLSPMSSSPANPSSEES 623

Query: 515 PLPGSQ-LSLSSPGSTEDEDTGRPLPPPHPQP--PPHPQPPDLDGHPEPSKAEVLRPESD 571
            LPG    S      T  ++TG P P P P    P H QP      P P+          
Sbjct: 624 QLPGPLGPSAFFHPPTHPQETGSPFPSPEPPHSLPTHYQPEPAKAFPFPADGLGAEGAFQ 683

Query: 572 ELDETDTP--GSEVG 584
            L+ET  P  G EVG
Sbjct: 684 CLEETPFPHEGPEVG 698



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 131/535 (24%), Positives = 183/535 (34%), Gaps = 89/535 (16%)

Query: 151  SPGGWKAITEKPPGGHEEAEEDHQGVGLRGE-EKPAGHRTS----PVAKISPGATLPESR 205
            SPGG +  T     GH+   E     GL G+ EK  G  T+    P   +SPG T   + 
Sbjct: 1930 SPGGVQVTTLPAVAGHQLGLEADGHWGLLGQAEKTQGQGTANQLQPENGVSPGGTDNHAS 1989

Query: 206  APDMSPQRISNQLHGTIAVVR-PGSQACPADRGPANGTPPPLPARSSPPSPAYER-GLSL 263
                    ++    G + + +  GS+A  + +  A  TP       SPPSP  E   L+L
Sbjct: 1990 VNASPKTALTGPTEGAVLLEKCKGSRAAMSLQEEAEPTP-------SPPSPNRESLALAL 2042

Query: 264  DSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLK 323
             +    S     T E    SP       LN+PL     SP         APS   L    
Sbjct: 2043 TAAHSRSGSEGRTPERAS-SPG------LNKPLLATGDSP---------APSVGDLAACA 2086

Query: 324  AREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGE 383
                 A   P  L  LP         R +G L       QL A     S   R  P P +
Sbjct: 2087 PSPTSAAHMPCSLGPLPREDPLTSPSRAQGGLG-----GQLPA-----SPSCRDPPGPQQ 2136

Query: 384  MLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLD 443
            +L   P  +  E  E +G +A         G    P  P       +  T  C    P +
Sbjct: 2137 LLACSPAWAPLE--EADGVQATTDT-----GAEDSPVAP------PSLTTSPC---DPKE 2180

Query: 444  LSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQ 503
                   +G+ +P            +A T +    T      R P+     ++  ++ E 
Sbjct: 2181 ALAGCLLQGEGSPLEDPSSWPPGSVSAVTCTHSGDTPKDSTLRIPE----DSRKEKLWES 2236

Query: 504  EEASTPMDPSRPLPGS--------QLSLSSPGSTEDEDTGRPLPPPHPQ---PPPHPQPP 552
               +T    S PL G+           LSS  + ++   GR LP P PQ    PPH  P 
Sbjct: 2237 PGRAT----SPPLAGAVSPSVAVRATGLSSTPTGDEAQAGRGLPGPDPQSRGAPPHTNPD 2292

Query: 553  DLD-GHPEPSKAEVLRPESDELDETDTPGSE------VGLSSQA--EATTSTTGEGPECI 603
             +  GH   S +   R    E        +E       G  S A  E    T+ + PE  
Sbjct: 2293 RMPRGHSSYSPSNTARLGHREGQAVTAVPTEPPTLQGAGPDSPACLEGEMGTSSKEPEDP 2352

Query: 604  CTQEHGQGPPRKRKRASEP----GDKASKKPSRGRRKLTATEGPGSPRDAEDHSP 654
             T E G+    K  R + P    G   +  PS        ++ P S R+A   +P
Sbjct: 2353 GTPETGRSGATKMPRVTCPSTGLGLGRTTAPSSTASDF-QSDSPQSHRNASHQTP 2406



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 107/484 (22%), Positives = 149/484 (30%), Gaps = 113/484 (23%)

Query: 167  EEAEEDHQGVGLRGEEKPAGHR---TSPVAKISPGATLPESRAPDMSPQRISNQLHGTIA 223
            +  E D   + +  +E+P+G R   +    K   G T PES+AP   P    +       
Sbjct: 856  DNPEIDSSFIDVFADEEPSGPRGPSSGHPLKSKAGVT-PESKAPPPLPAATPDP-----Q 909

Query: 224  VVRPGSQACPADRGPANGTPPPLPARSSPPSPAYE--RGLSLDSF--------------- 266
              RPG + CPA   P   +    P  +  PS   +  RG  L  F               
Sbjct: 910  TPRPGDRGCPARGRPKTRSLGLAPTEADAPSQGRQQRRGKQLKLFRKDLDSGGAAEGSGS 969

Query: 267  --------LRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHS----SPLAPAAAP 314
                    LR  R   +    P             RP     Q+P S    +P  P AA 
Sbjct: 970  GGGGRASGLRPRRNDGLGERPPP------------RPRRPRTQAPGSRADPAPRVPRAAA 1017

Query: 315  SDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVR 374
                 +  + R     ++P +      A         E  L ++  + +LR    A    
Sbjct: 1018 LPEETRSSRRRRLPPRKDPRKRKARGGAWGK------ELILKIVQQKNRLREYDFASESE 1071

Query: 375  PRGQPTP-----------GEMLPSLPVGSDSEGPENEGTR-AALAAAGLSG--------- 413
               QP P           GE    + +       E +  R AA   AG  G         
Sbjct: 1072 EDEQPPPRGPGFRGRRGRGEKRKEVELTQGPREDEPQKPRKAARQEAGGDGAPANPEEPG 1131

Query: 414  ------GRHTQPAGPGRAQRTEAAATQ---------DCALDKPLDLSEWGRARGQDTPKP 458
                  GR  Q  GP R+  T AAA +           A   PL +        +  P  
Sbjct: 1132 GSRPGPGRSPQARGPSRSLETGAAAREGGPKCADRPSVAPKDPLQVPTNTETSEETRPSL 1191

Query: 459  AGQHGSLSPAAAHTASPE-----------PPTQSGPLTRSPQAL-------SNGTKGTRV 500
                 +  P  A  ++P+           P   +G +  SP  L       S    GT  
Sbjct: 1192 DFPQEAKEPETAEESAPDSTEFTEALRSPPAACAGEMGASPGLLIPEQPPPSRHDTGTPK 1251

Query: 501  PEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQP---PDLDGH 557
            P    A+T    S P PG    L  PG T+   +     PP  QP     P   P     
Sbjct: 1252 PSGSLANTAPHGSSPTPGVGSLLGGPGGTQAPVSHNSKDPPARQPGEFLAPVANPSSTAC 1311

Query: 558  PEPS 561
            P+PS
Sbjct: 1312 PKPS 1315



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 122/535 (22%), Positives = 165/535 (30%), Gaps = 111/535 (20%)

Query: 184  PAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTP 243
            P    T P    SP      S  PD+   R    L+G+++  R            A   P
Sbjct: 1406 PGTAETEPGRAASPPTLESSSLFPDLPVDRFDPPLYGSLSANRDSGLPF------ACADP 1459

Query: 244  PPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSP 303
            P     S PP P++         L    P   +H       KV           L    P
Sbjct: 1460 PQKTVPSDPPYPSF-------LLLEEVSPMLPSHFPDLSGGKV-----------LSKTCP 1501

Query: 304  HSSPLAPAAAPSDP---------RLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGA 354
                + P AAPS P          +  L   E E  +  TE   L S L   +D R    
Sbjct: 1502 PERTVVPGAAPSLPGKGSGCSVALMSHLSEDELEIQKLVTE---LESQLQRSKDTR-GAP 1557

Query: 355  LHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSE-------GPENEGTRAALA 407
              L  A+   R     G+  P  + T    +P     S ++           EG  +A+A
Sbjct: 1558 RELAEAESVGRVELGTGTEPPSQRRTCQATVPHEDTFSAADLTRVGESTAHREGAESAVA 1617

Query: 408  AA----GLSGGRHTQPAG--PGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQ 461
                  G  GG    PA   PG A      A +D     P           Q   K    
Sbjct: 1618 TVEAVQGRPGGTWPCPASFHPGHAALL-PCAQEDLVSGAPFS-PRGANFHFQPVQKAGAS 1675

Query: 462  HGSLSPAAAHT------ASPEPPTQSGP-LTRSPQALSNGTKGTRVPEQEEASTPM---D 511
               L  A   +        PEP  Q GP L     A  +  +    P+ +EA++     D
Sbjct: 1676 KTGLCQAEGDSRPPQDVCLPEPSKQPGPQLDAGSLAKCSPDQELSFPKNKEAASSQESED 1735

Query: 512  PSRPLPGSQLS--LSSPGSTEDEDTGRPLPPPHPQPPPHPQP---------PDLD----- 555
              R LP  Q    L  PG+ +    G P P     P  H  P         P LD     
Sbjct: 1736 SLRLLPCEQRGGFLPEPGTADQPHRGAPAPEAFGSPAVHLAPDLAFQGDGAPPLDATWPF 1795

Query: 556  ---------GHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEG------- 599
                     GH        L P +        PG E    + A A++ T   G       
Sbjct: 1796 GASPSHAAQGHSAGRAGGHLHPTAGR------PGFEGNEFAPAGASSLTAPRGREAWLVP 1849

Query: 600  ---PECIC-------TQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLT-ATEGP 643
               P C+        +Q+    PP ++ +   PG   SK    G ++LT A + P
Sbjct: 1850 VPSPACVSNTHPSRRSQDPALSPPIRQLQLPGPGVAKSKDGILGLQELTPAAQSP 1904



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 139/600 (23%), Positives = 180/600 (30%), Gaps = 147/600 (24%)

Query: 146  PLLLPSPGGWKAITEKP-PGGHEEAEEDHQG-VGLRG------EEKPA------------ 185
            P   PSP G + ++  P P G  E +   QG +G  G      E+ PA            
Sbjct: 489  PTARPSPHGMEMLSRLPFPAGGPEWQGGSQGALGTAGKTPGPREKLPAVRSSQGGSPALF 548

Query: 186  --GHRTSPVAK----------ISPGAT--LPESRAPDMSPQRISNQLHGTIAVVRPGSQA 231
                 T P A+          +SP  T  LP  R    SP         T       S  
Sbjct: 549  TYNGMTDPGAQPLFFGVAQPQVSPHGTPSLPPPRVVGASPSESPLPSPATNTAGSTCSSL 608

Query: 232  CPADRGPANGT-----------------PPPLPARSSPPSPAYERGLSLDSFLRASRPSA 274
             P    PAN +                 PP  P  +  P P+ E   SL +  +     A
Sbjct: 609  SPMSSSPANPSSEESQLPGPLGPSAFFHPPTHPQETGSPFPSPEPPHSLPTHYQPEPAKA 668

Query: 275  MTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSP-LAPAAAPSDPRLQDLKAREAEAWEEP 333
                A  L  +    CL   P       PH  P +        PR              P
Sbjct: 669  FPFPADGLGAEGAFQCLEETPF------PHEGPEVGRGGLQGFPRAPP---------PYP 713

Query: 334  TELLGLPSALAGMQDLRLE--------GALHLLLAQQQ----LRARARAGSVRPRGQPTP 381
            T    L SA     D+ L          +L   LA +Q    L ARA+ G  R  G P  
Sbjct: 714  THHFSLSSASLDQLDVLLTCRQCDRNYSSLAAFLAHRQFCGLLLARAKDGHQRSPGPPG- 772

Query: 382  GEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKP 441
               LPS P         + G         LS  +    AG  +A+            D P
Sbjct: 773  ---LPSPPAAPRVPADAHAGL--------LSHAKTFLLAGDAQAE----------GKDDP 811

Query: 442  LDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVP 501
            L             P PA        A   +   E        + +P+  S+      V 
Sbjct: 812  LRTGFLPSLAATPFPLPASDLDMEDDAKLDSLITEALNGMEYQSDNPEIDSSFID---VF 868

Query: 502  EQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPS 561
              EE S P  PS   P     L S      E      PPP P   P PQ P       P+
Sbjct: 869  ADEEPSGPRGPSSGHP-----LKSKAGVTPESKA---PPPLPAATPDPQTPRPGDRGCPA 920

Query: 562  KAEVLRPESDEL----DETDTPGS-------------EVGLSSQAEATTSTTGEGPECIC 604
            +    RP++  L     E D P                  L S   A  S +G G     
Sbjct: 921  RG---RPKTRSLGLAPTEADAPSQGRQQRRGKQLKLFRKDLDSGGAAEGSGSGGG----- 972

Query: 605  TQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSPWEET 664
                G+    + +R    G++   +P R R     T+ PGS  D     P   + P EET
Sbjct: 973  ----GRASGLRPRRNDGLGERPPPRPRRPR-----TQAPGSRADPAPRVPRAAALP-EET 1022



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 99/404 (24%), Positives = 131/404 (32%), Gaps = 82/404 (20%)

Query: 168  EAEEDHQ----GVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIA 223
            E+EED Q    G G RG       R        P    P+       P++ + Q  G   
Sbjct: 1069 ESEEDEQPPPRGPGFRGRRGRGEKRKEVELTQGPREDEPQK------PRKAARQEAGGDG 1122

Query: 224  VV---------RPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSA 274
                       RPG    P  RGP+        AR   P  A                  
Sbjct: 1123 APANPEEPGGSRPGPGRSPQARGPSRSLETGAAAREGGPKCA------------------ 1164

Query: 275  MTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAA-APSDPRLQDLKAREAEAWEEP 333
               + P ++PK         PL +   +  S    P+   P + +  +     A    E 
Sbjct: 1165 ---DRPSVAPK--------DPLQVPTNTETSEETRPSLDFPQEAKEPETAEESAPDSTEF 1213

Query: 334  TELL-GLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRG---QPTPGEMLPSLP 389
            TE L   P+A AG     +  +  LL+ +Q   +R   G+ +P G      P    P+  
Sbjct: 1214 TEALRSPPAACAG----EMGASPGLLIPEQPPPSRHDTGTPKPSGSLANTAPHGSSPTPG 1269

Query: 390  VGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGR 449
            VGS   GP   GT+A      +S      PA          A     A  KP  LS    
Sbjct: 1270 VGSLLGGP--GGTQAP-----VSHNSKDPPARQPGEFLAPVANPSSTACPKPSVLSSKIS 1322

Query: 450  ARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGP---LTRSPQALSNGTKGTRVPEQEEA 506
            + G D   PAG   +  P     A   P   S P   L   P+ L+        P+    
Sbjct: 1323 SFGCD---PAG--FNRDPLGVPVAKKGPQPYSSPHSELFLGPKDLAGCFLEELHPKPSAR 1377

Query: 507  STPMDPSRPL------PGS---QLSLSSPGSTEDEDTGRPLPPP 541
              P   S  L       GS   QL  S PG+ E E  GR   PP
Sbjct: 1378 DAPPASSSCLCQDGEDAGSLEPQLPRSPPGTAETE-PGRAASPP 1420



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 45/203 (22%), Positives = 71/203 (34%), Gaps = 18/203 (8%)

Query: 469  AAHTASPEPPTQSGPLTRSPQALSNGTKG---TRVPEQEEASTPMDPSRPLPGSQLSLSS 525
            A+ +   E P   GP  R  +      K    T+ P ++E   P   +R   G      +
Sbjct: 1067 ASESEEDEQPPPRGPGFRGRRGRGEKRKEVELTQGPREDEPQKPRKAARQEAGGD---GA 1123

Query: 526  PGSTEDEDTGRPLPPPHPQPPPHPQPPDL-----DGHPEPSKAEVLRPESDELDETDTPG 580
            P + E+    RP P   PQ     +  +      +G P+ +    + P+      T+T  
Sbjct: 1124 PANPEEPGGSRPGPGRSPQARGPSRSLETGAAAREGGPKCADRPSVAPKDPLQVPTNTET 1183

Query: 581  SE---VGLSSQAEATTSTTGE--GPECICTQEHGQGPPR--KRKRASEPGDKASKKPSRG 633
            SE     L    EA    T E   P+     E  + PP     +  + PG    ++P   
Sbjct: 1184 SEETRPSLDFPQEAKEPETAEESAPDSTEFTEALRSPPAACAGEMGASPGLLIPEQPPPS 1243

Query: 634  RRKLTATEGPGSPRDAEDHSPSP 656
            R      +  GS  +   H  SP
Sbjct: 1244 RHDTGTPKPSGSLANTAPHGSSP 1266



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 37/145 (25%), Positives = 54/145 (37%), Gaps = 20/145 (13%)

Query: 456  PKPAGQHGSLSPAAAHTASP-EPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSR 514
            P P G     SPAA     P EP  Q     + P+  S+   G   P       P   ++
Sbjct: 2469 PHP-GAPAEPSPAALPAQQPLEPLAQK---CQPPRKKSHRVSGKERPNHSRGD-PSHVTQ 2523

Query: 515  PLP--GSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDE 572
            P P  GS+  L +PGS   +    P P  H       + P     P+ ++ + L P+  E
Sbjct: 2524 PPPAQGSKEVLRAPGSPHSQQLHPPSPTEH---EVDVKTPASKPRPDQAREDELHPKQAE 2580

Query: 573  LDE---------TDTPGSEVGLSSQ 588
              E          D+P    G S++
Sbjct: 2581 KREGRRWRREPTVDSPSHSEGKSNK 2605


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
           sapiens]
          Length = 2462

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/231 (21%), Positives = 88/231 (38%), Gaps = 17/231 (7%)

Query: 424 RAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGP 483
           + ++  AAA+++ A    ++  E       +    +G    +   A  T +    T+S P
Sbjct: 682 KKKKAPAAASEEAAFPPVVEDEE------MEASGVSGNEEEMVEEAEATVNNSSDTESIP 735

Query: 484 LTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHP 543
              +  A   G  G + P    A  P       P   +   +  +   E TG P PP  P
Sbjct: 736 SPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP--P 793

Query: 544 QPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECI 603
            PP    PP +    E  +     P  +E +E   P +E     +    T    E  +  
Sbjct: 794 APPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAE-----ELAVDTGKAEEPVKSE 848

Query: 604 CTQEHGQGPPR----KRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAE 650
           CT+E  +GP +    +   A+  G   ++K   G  + T  +  G+P+D++
Sbjct: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 121/565 (21%), Positives = 181/565 (32%), Gaps = 109/565 (19%)

Query: 28   ELNSERCRDAQRIEELFS-----KNHQLREQQKTLKENLRVLENRLRAGLCDRCMVTQEL 82
            E NSE     Q+  EL S      +    E+ +T K+ L  LE+        R + ++ +
Sbjct: 589  EANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGL--LEHGRNWSAIARMVGSKTV 646

Query: 83   ARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRVLGDRPKPRAKE---- 138
            ++ +   F     QNL  I +  +++   KE N   K++        +   P   E    
Sbjct: 647  SQCKNFYFNYKKRQNLDEI-LQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEM 705

Query: 139  ---GTSDPPSPLLLPSPG--GWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVA 193
               G S     ++  +       + TE  P  H EA +D    G  G + PA        
Sbjct: 706  EASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKD---TGQNGPKPPA-------- 754

Query: 194  KISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPP 253
              + GA  P    P   P+ I      T           PA       TPPP P   S P
Sbjct: 755  --TLGADGPPPGPPTPPPEDIPAPTEPT-----------PASEATGAPTPPPAPPSPSAP 801

Query: 254  SPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAA 313
             P   +    +    A+ P     E  K  P  + L +         + P  S     A 
Sbjct: 802  PPVVPKEEKEEE--TAAAPPVEEGEEQK-PPAAEELAVDTG----KAEEPVKSECTEEAE 854

Query: 314  PSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSV 373
                + +D +A EA A                      EGAL    A+++     RA + 
Sbjct: 855  EGPAKGKDAEAAEATA----------------------EGALK---AEKKEGGSGRATTA 889

Query: 374  RPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAAT 433
            +  G P   +   +       E    +  R       L       P G  RA        
Sbjct: 890  KSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL-----LTPTGDPRA-------- 936

Query: 434  QDCALDKPLDLSEWGRARG-----QDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSP 488
             + +  KPLDL +  +        Q T          +P      +P PP    P + +P
Sbjct: 937  -NASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP 995

Query: 489  QALSNGTKG----TRVPEQEEASTPM-DPSRPLPGSQLSLSSPGSTEDEDTGRPLP-PPH 542
            Q   +  +G       P  +EA  P+  P+      +L    PG      +G P P PP 
Sbjct: 996  QQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKL----PGDPPCWTSGLPFPVPPR 1051

Query: 543  PQPPPHPQPPDLD-------GHPEP 560
                  P  PD         GHP P
Sbjct: 1052 EVIKASPHAPDPSAFSYAPPGHPLP 1076



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 67/319 (21%), Positives = 99/319 (31%), Gaps = 77/319 (24%)

Query: 377  GQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDC 436
            G PTP    PS P       P+ E      AA  +  G   +P         +    ++ 
Sbjct: 787  GAPTPPPAPPS-PSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA-AEELAVDTGKAEEP 844

Query: 437  ALDKPLDLSEWGRARGQDTP----------KPAGQHGSLSPAAAHTASPEPPTQSGPLTR 486
               +  + +E G A+G+D            K   + G    A    +S  P       T 
Sbjct: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904

Query: 487  SPQALSN---GTKGTRVPEQEEASTPM-------DPSRPLPGSQLSLSSPGSTEDEDTGR 536
            S   +     G K   +  +    TP         P +PL   QL   +      + T  
Sbjct: 905  SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964

Query: 537  PLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTT 596
              PP     P  P PP       P   + L+PESD                         
Sbjct: 965  HEPPREDAAPTKPAPP------APPPPQNLQPESD------------------------- 993

Query: 597  GEGPECICTQEHGQGPPRKRKRASEPGDKASKKP------SRGRRKLTA-----TEG--- 642
                     Q+ G  P  K +  + P DK ++KP      +   +KL       T G   
Sbjct: 994  -------APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPF 1046

Query: 643  PGSPRD---AEDHSPSPNS 658
            P  PR+   A  H+P P++
Sbjct: 1047 PVPPREVIKASPHAPDPSA 1065



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 55/285 (19%), Positives = 89/285 (31%), Gaps = 38/285 (13%)

Query: 375  PRGQPTPGEMLPSLPVGSDSEG-PENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAAT 433
            P G PTP    P   + + +E  P +E T A              P  P   +  E AA 
Sbjct: 762  PPGPPTP----PPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAA 817

Query: 434  QDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSN 493
                   P++        G++   PA +       A  T   E P +S     + +  + 
Sbjct: 818  P------PVE-------EGEEQKPPAAEE-----LAVDTGKAEEPVKSECTEEAEEGPAK 859

Query: 494  GTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPD 553
            G          E +   +      G   +  S G+ +D D+                  +
Sbjct: 860  GKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC-----------SADE 908

Query: 554  LDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATT--STTGEGPECICTQEHGQG 611
            +D      K  +L P    L  T  P +        +           P    T+ H   
Sbjct: 909  VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHE-- 966

Query: 612  PPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSP 656
            PPR+    ++P   A   P   + +  A + PGS    +  SP+P
Sbjct: 967  PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP 1011


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 122/503 (24%), Positives = 185/503 (36%), Gaps = 76/503 (15%)

Query: 204  SRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSL 263
            S AP    Q    Q+  ++A     +Q+ PA  GPA  T   L   + PPS A     + 
Sbjct: 543  SAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTV--LQGVTLPPS-AVAMLNTP 599

Query: 264  DSFLRASRPSAMTHEAPKL---SPKVDRLCLLNRPLSLHLQSPHSS--PLAP---AAAPS 315
            D  ++ + P+A T EA  +    P       ++ PL L LQ P +   P AP   AAAP 
Sbjct: 600  DGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAP- 658

Query: 316  DPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARA----- 370
             P+    +     A      +LG P + A    +  + +L + L Q++ +    A     
Sbjct: 659  -PQATTPQPSPGLASSPEKIVLGQPPS-ATPTAILTQDSLQMFLPQERSQQPLSAEGPHL 716

Query: 371  ---GSVRPRGQPTPGEMLPSLPV----GSDSEGPENEGTRAAL----AAAGLSG-GRHTQ 418
                SV     P   +  P+ PV    G   + P+++ + A      AAA L G G  + 
Sbjct: 717  SVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSS 776

Query: 419  PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPE-- 476
            P+ P +A   ++         +P        +R Q   +P  +   L P     A P   
Sbjct: 777  PSLPHQAPLGDSPHLPSPHPTRPPSRPP---SRPQSVSRPPSEP-PLHPCPPPQAPPTLP 832

Query: 477  -----------PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSS 525
                       PP  S P   +P       +    P+ +    P+ P+  LP S  S + 
Sbjct: 833  GIFVIQNQLGVPPPASNPAPTAPGPPQPPLR----PQSQPPEGPLPPAPHLPPSSTSSAV 888

Query: 526  PGSTEDEDTGRPLPPPHPQ------PP---PHPQ---PPDLDGHPEPSKAEVLRPESDEL 573
              S+E   T   LP P P       PP   PH     PP L   PEP+      P + ++
Sbjct: 889  ASSSE---TSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQM 945

Query: 574  DETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRG 633
              T  P        Q +A      + P  I  Q    G P   + ++  G   S   S  
Sbjct: 946  VTTPFPA-----LPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAAS-- 998

Query: 634  RRKLTATEGPGSPRDAEDHSPSP 656
               L + + P     A  H+P+P
Sbjct: 999  --VLVSGQAPSGTPTAPSHAPAP 1019



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 80/350 (22%), Positives = 120/350 (34%), Gaps = 36/350 (10%)

Query: 272 PSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWE 331
           P+  T  AP   P       L++P+S+HL +  SS + PA     P         A A +
Sbjct: 428 PATTTGAAPPQPPGA-----LSKPMSVHLLNQGSSIVIPAQHML-PGQNQFLLPGAPAVQ 481

Query: 332 EPTELLGLPSALAGMQDLRLEGALHL--------LLAQQQLRARARAGSV-RPRGQPTPG 382
            P +L  LP+ + G   +    A H         +L  Q L      G V  P       
Sbjct: 482 LPQQLSALPANVGG--QILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSA 539

Query: 383 EMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCAL---- 438
            +L + P+      P       +LAA  L       PAGP      +       A+    
Sbjct: 540 HILSAAPIQVGQ--PALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLN 597

Query: 439 --DKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASP----EPPTQSGPLTRSPQALS 492
             D  +  +    A G+  P    Q    +P A  T  P    +P  Q  P   +PQA +
Sbjct: 598 TPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAA 657

Query: 493 NGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPP 552
                T  P    AS+   P + + G   S +       +     LP    Q P   + P
Sbjct: 658 PPQATTPQPSPGLASS---PEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGP 714

Query: 553 DLDGHPEPSKAEVLRPESDELDETDTPGSE-VGLSSQAEATTSTTGEGPE 601
            L     P+   V  P   +     TP ++  GL  QA  + ++    P+
Sbjct: 715 HLS---VPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQ 761


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 133/569 (23%), Positives = 199/569 (34%), Gaps = 120/569 (21%)

Query: 135  RAKEGTSDPPSPLLLPSPGGWKAITEKPPGG--HEEA------EEDHQGVGLRGEEKPAG 186
            R  EG+   P+PL  P+       +++PP G  H  +      ++  QG+G      PA 
Sbjct: 519  RLLEGSLGEPTPLPPPT-------SQQPPVGAPHRASGTSPLKQKGPQGLGQPSGPLPA- 570

Query: 187  HRTSPVA-KISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPP 245
             + SP++ K SP   LP   +P   P R S           P S      R P    P P
Sbjct: 571  -KASPLSTKASP---LPSKASPQAKPLRASEPSK------TPSSVQEKKTRVPTKAEPMP 620

Query: 246  LPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHS 305
             P   + P+PA  +   + S +R + P+    +A   +PK               +    
Sbjct: 621  KPPPETTPTPATPK---VKSGVRRAEPATPVVKAVPEAPKGGEA-----------EDLVG 666

Query: 306  SPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLR 365
             P +  A+ S   L D            +E+ G+                     QQ++ 
Sbjct: 667  KPYSQDASRSPQSLSDTGYSSDGISSSQSEITGV--------------------VQQEVE 706

Query: 366  ARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQP--AGPG 423
                AG   P   P+P E+     VGS          R  L A GL+    ++P  +G G
Sbjct: 707  QLDSAGVTGPH-PPSPSEIHK---VGSSM--------RPLLQAQGLAPSERSKPLSSGTG 754

Query: 424  RAQR--------TEAAATQDCALDKPL----DLSEWGRARGQ-DTPKPAGQHGSL----- 465
              Q+        T  A   D  L+  L    D +EW R R Q DT + +   GS      
Sbjct: 755  EEQKQRPHSLSITPEAFDSDEELEDILEEDEDSAEWRRRREQQDTAESSDDFGSQLRHDY 814

Query: 466  ----SPAAAHTASPEPPTQSGPLTRSP----QALSNGTKGTRVPEQEEASTPMDPSRPLP 517
                S        P+PP ++  LT       Q L    +   + E + A+          
Sbjct: 815  VEDSSEGGLSPLPPQPPARAAELTDEDFMRRQILEMSAEEDNLEEDDTAT---------- 864

Query: 518  GSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETD 577
             S   L+  G+ +    G P P P P   P   P     H   +  E L PE    + TD
Sbjct: 865  -SGRGLAKHGTQK----GGPRPRPEPSQEPAALPKRRLPHNATTGYEELLPEGGSAEATD 919

Query: 578  TPGS-EVGLSSQAEATTSTTGE-GPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRR 635
              G+ + GL        ++TG  G E    Q  G  P   R+   E          R R 
Sbjct: 920  GSGTLQGGLRRFKTIELNSTGSYGHELDLGQ--GPDPSLDREPELEMESLTGSPEDRSRG 977

Query: 636  KLTATEGPGSPRDAEDHSPSPNSSPWEET 664
            + ++T    +P      SP+  SS  E++
Sbjct: 978  EHSSTLPASTPSYTSGTSPTSLSSLEEDS 1006



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 134/608 (22%), Positives = 205/608 (33%), Gaps = 128/608 (21%)

Query: 105  TNEMNGLKEENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPG 164
            ++E   L+EE E L+E+ K   V   R +  A++   D             +  ++ PP 
Sbjct: 1040 SSEEEELREEEELLREQEKMREVEQQRIRSTARKTRRDKEELRAQRR----RERSKTPPS 1095

Query: 165  GHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATL-PESRAPDMSPQRISNQLHGTIA 223
                 E+      LR   +      S  ++ SP  +L  E+ A D  P R+         
Sbjct: 1096 NLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSPSLDSEAEALDGGPSRL--------- 1146

Query: 224  VVRPGSQ-ACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKL 282
              + GS+   P      + T  P  + ++P S                RP     EA + 
Sbjct: 1147 -YKSGSEYNLPTFMSLYSPTETPSGSSTTPSS---------------GRPLKSAEEAYEE 1190

Query: 283  SPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPR------LQDLKAREAEAWEEPTEL 336
              +   L    +  +   + PH  P    + P+ PR       QD   RE     +P   
Sbjct: 1191 MMRKAELLQRQQGQAAGARGPHGGP----SQPTGPRGLGSFEYQDTTDREYGQAAQPA-A 1245

Query: 337  LGLPSALA------------GMQDLRLEGALHLLLAQQQLRAR-------ARAGSVRPRG 377
             G P++L              +  +R   +  L  A+ + + +       A    ++  G
Sbjct: 1246 EGTPASLGAAVYEEILQTSQSIVRMRQASSRDLAFAEDKKKEKQFLNAESAYMDPMKQNG 1305

Query: 378  QP-TPGEMLPSL--------PVGSDSEG----PENEGTRAALAAAGLSGGRHTQPAGPGR 424
             P TPG     L        P  SDS G    P+   T+            H+ PA P  
Sbjct: 1306 GPLTPGTSPTQLAAPVSFSTPTSSDSSGGRVIPDVRVTQHFAKETQDPLKLHSSPASPSS 1365

Query: 425  AQR------TEAAATQDCALDKPLDLSEWGRARGQDTP-KPAGQHGSLSPAA-AHTASPE 476
            A +      ++   T       P      G  RG  TP  PAG   S SP++ AH+    
Sbjct: 1366 ASKEIGMPFSQGPGTPATTAVAPCPA---GLPRGYMTPASPAGSERSPSPSSTAHSYGHS 1422

Query: 477  PPT-----QSGPLTRSPQAL--------------SNGTKGTRVPEQ-----EEASTPMDP 512
            P T     Q+  L ++P  L              S+G  GT  P +       +S P+ P
Sbjct: 1423 PTTANYGSQTEDLPQAPSGLAAAGRAAREKPLSASDGEGGTPQPSRAYSYFASSSPPLSP 1482

Query: 513  SRPLPGSQLS--LSSPGSTEDEDTGRPLPPPHPQPP-----PHPQPPDLDGHPEPSKAEV 565
            S P      S     P +T +  T  P P P    P     P P P    G   P +   
Sbjct: 1483 SSPSESPTFSPGKMGPRATAEFSTQTPSPAPASDMPRSPGAPTPSPMVAQGTQTPHRPST 1542

Query: 566  LRPESDELDETDTPGSEVGLSSQAEATT----STTGEGPECICTQ----EHGQG---PPR 614
             R    E  + + P   + L+S A + T    ++    P C  T+     HG     PP 
Sbjct: 1543 PRLVWQESSQ-EAPFMVITLASDASSQTRMVHASASTSPLCSPTETQPTTHGYSQTTPPS 1601

Query: 615  KRKRASEP 622
              +   EP
Sbjct: 1602 VSQLPPEP 1609



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 82/340 (24%), Positives = 108/340 (31%), Gaps = 78/340 (22%)

Query: 150  PSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDM 209
            P  G W    E  PG H  A+E   G   R   +  G          PG    +  A D+
Sbjct: 3624 PEEGLWPH-DEGGPGRHASAKEHRHGDHGRHSGRHTGEE--------PGRRAAKPHARDL 3674

Query: 210  SPQRISNQLHGTIAVVRPGSQACPADRGPANGTPP-PLPARSSPPSPAYERGLSLDSFLR 268
                            RP SQ   A   P  G P  P  A  S PS A           +
Sbjct: 3675 GRHE-----------ARPHSQPSSAPAMPKKGQPGYPSSAEYSQPSRASSAYHHASDSKK 3723

Query: 269  ASR-----PSAMTHEA-PKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDL 322
             SR     P+A+  +A P+  P++        P     QSP S  +   AA   P+ Q  
Sbjct: 3724 GSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQS--QSPSSRQIPSGAASRQPQTQ-- 3779

Query: 323  KAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPG 382
                     +  + LGL      +   RL+       +Q   R  A A S +P G+P PG
Sbjct: 3780 ---------QQQQGLGLQPPQQALTQARLQQQ-----SQPTTRGSAPAAS-QPAGKPQPG 3824

Query: 383  EMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPL 442
                     S + GP                    QPAGP RA++T  +        K  
Sbjct: 3825 P--------STATGP--------------------QPAGPPRAEQTNGSK----GTAKAP 3852

Query: 443  DLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSG 482
                  +A+    P PAG      P     A    P   G
Sbjct: 3853 QQGRAPQAQPAPGPGPAGVKAGARPGGTPGAPAGQPGADG 3892



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 39/152 (25%), Positives = 54/152 (35%), Gaps = 24/152 (15%)

Query: 512 PSRPLPGSQLSLSSPGSTEDEDTG-RPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPES 570
           PS P  G QL    P +     T   P+P P P P P P P       +P +     P  
Sbjct: 37  PSAPAGGGQL----PAAGAARSTAVPPVPGPGPGPGPGPGPGSTSRRLDPKE-----PLG 87

Query: 571 DELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRK---RASEPGDKAS 627
           ++   + TP      +   E+   T  +GP      +   GP R  +   R    G   S
Sbjct: 88  NQRAASPTPKQASATTPGHESPRETRAQGP----AGQEADGPRRTLQVDSRTQRSGRSPS 143

Query: 628 KKPSRGRRKLTATEGPGSPRDAEDHSPSPNSS 659
             P RG         P SP      +P P+S+
Sbjct: 144 VSPDRG-------STPTSPYSVPQIAPLPSST 168



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 127/514 (24%), Positives = 174/514 (33%), Gaps = 66/514 (12%)

Query: 168  EAEEDHQGVGLRGEEKPAGHRTSP----VAKISPGATLP-ESRAPDMSPQRISNQLHGTI 222
            + E D Q  G+ G +       SP    +  ++PG     E + PD  P  I  Q H   
Sbjct: 2719 QTEPDGQAQGVAGPQLVGPTAISPYLPGIQIVTPGPLGRFEKKKPD--PLEIGYQAH--- 2773

Query: 223  AVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKL 282
              + P S +    R P   +P  L +  SP SP       LD+   +S      H +P+ 
Sbjct: 2774 --LPPESLSQLVSRQPPK-SPQVLYSPVSPLSPHR----LLDTSFASSERLNKAHVSPQK 2826

Query: 283  SPKVD---RLCLLNRPL-SLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLG 338
                D   R   L RP+ +L        PL+P A  S      L   +     + + L  
Sbjct: 2827 HFTADSALRQQTLPRPMKTLQRSLSDPKPLSPTAEESAKERFSLYQHQGGLGSQVSALP- 2885

Query: 339  LPSALAGMQDLRLEGA----LHLLLAQQ---QLRARA--RAGSVRPRGQP-TPGEMLPSL 388
             P++L       L        HL LA Q   QL A +  + G   P   P T   +L  L
Sbjct: 2886 -PNSLVRKVKRTLPSPPPEEAHLPLAGQASPQLYAASLLQRGLTGPTTVPATKASLLREL 2944

Query: 389  PVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGP-----GRAQRTEAAATQDCALDKP-- 441
                D    E+E T+     A L        A       G  QR E+ A      D P  
Sbjct: 2945 D--RDLRLVEHESTKLRKKQAELDEEEKEIDAKLKYLELGITQRKESLAKDRGGRDYPPL 3002

Query: 442  ---------LDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPT-----QSGPLTRS 487
                     L  SE  + R Q    PAGQ       AA  A+P  PT     +  P    
Sbjct: 3003 RGLGEHRDYLSDSELNQLRLQGCTTPAGQFVDFPATAAAPATPSGPTAFQQPRFQPPAPQ 3062

Query: 488  PQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPG--STEDEDTGRPLPPPHPQP 545
              A S G      P  +  + P   + P P      S P      ++   RP      Q 
Sbjct: 3063 YSAGSGGPTQNGFPAHQAPTYPGPSTYPAPAFPPGASYPAEPGLPNQQAFRPTGHYAGQT 3122

Query: 546  PPHPQPPDLDGHPEPSKAEVLRPESDELD--ETDTPGSEVGLSS----QAEATTSTTGEG 599
            P       L   P  S+A + +P    L   E   P +   ++S     + A + T+  G
Sbjct: 3123 PMPTTQSTLFPVPADSRAPLQKPRQTSLADLEQKVPTNYEVIASPVVPMSSAPSETSYSG 3182

Query: 600  PECICTQEHGQGP--PRKRKRASEPGDKASKKPS 631
            P      E G+ P  PR   R S     A   PS
Sbjct: 3183 PAVSSGYEQGKVPEVPRAGDRGSVSQSPAPTYPS 3216



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 27/111 (24%), Positives = 44/111 (39%), Gaps = 8/111 (7%)

Query: 527  GSTEDEDTGRPLPPPHP------QPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPG 580
            G    E+ GR    PH       +  PH QP      P+  K +   P S E  +     
Sbjct: 3655 GRHTGEEPGRRAAKPHARDLGRHEARPHSQPSSAPAMPK--KGQPGYPSSAEYSQPSRAS 3712

Query: 581  SEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPS 631
            S    +S ++  +     GP  + ++   Q  P+ + R + PG + S+ PS
Sbjct: 3713 SAYHHASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPS 3763



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 46/190 (24%), Positives = 69/190 (36%), Gaps = 21/190 (11%)

Query: 375  PRGQPTPGEMLPSLPVG-SDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQR------ 427
            P G    G      P+  SD EG   + +RA    A  S      P+ P  +        
Sbjct: 1439 PSGLAAAGRAAREKPLSASDGEGGTPQPSRAYSYFA--SSSPPLSPSSPSESPTFSPGKM 1496

Query: 428  -TEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASP--EPPTQSGPL 484
               A A        P   S+  R+ G  TP P    G+ +P    T     +  +Q  P 
Sbjct: 1497 GPRATAEFSTQTPSPAPASDMPRSPGAPTPSPMVAQGTQTPHRPSTPRLVWQESSQEAPF 1556

Query: 485  TRSPQALSNGTKGTRVPEQEEASTPM-DPSRPLPGSQ-LSLSSPGSTEDEDTGRPLPPPH 542
                 A S+ +  TR+     +++P+  P+   P +   S ++P S         LPP  
Sbjct: 1557 MVITLA-SDASSQTRMVHASASTSPLCSPTETQPTTHGYSQTTPPSVSQ------LPPEP 1609

Query: 543  PQPPPHPQPP 552
            P PP  P+ P
Sbjct: 1610 PGPPGFPRVP 1619



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 52/214 (24%), Positives = 75/214 (35%), Gaps = 37/214 (17%)

Query: 440 KPLDLSEWGRARGQDTPKPAGQHGSLS-----PAAAHTA--------SPEPPTQSGPLT- 485
           +PL   +  R+RG   P+P  +    +     P  A  A        SP+PP  + P T 
Sbjct: 256 QPLGKPDQERSRGPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPSTA 315

Query: 486 --RSPQALSNGTKGTRVPEQEEAS--TPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPP 541
             R P   +     T VP    A+  T    +  L G   SL +  ST        L   
Sbjct: 316 EPRPPAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASLLTQAST--------LMSV 367

Query: 542 HPQPPPHPQPPDLDGHP-----EPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTT 596
            P+     QP    G P     + SK    +P    L     PG   G  ++  A     
Sbjct: 368 QPEADTQGQPAPSKGTPKIVFNDASKEAGPKP----LGSGPGPGPAPGAKTEPGARMG-P 422

Query: 597 GEGPECICTQEHGQGPPRKRKRASEPGDKASKKP 630
           G GP  +  +  G   P+  +   +   KA+ KP
Sbjct: 423 GSGPGAL-PKTGGTTSPKHGRAEHQAASKAAAKP 455


>gi|50428935 BPY2 interacting protein 1 [Homo sapiens]
          Length = 1059

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 119/516 (23%), Positives = 173/516 (33%), Gaps = 99/516 (19%)

Query: 180 GEEKPAGHRTSPVAKISPGATLPESRAPD------------MSPQRISNQLHGTIAVVRP 227
           G+E+P   R  P    +P  T  E++ P               P+ +         + + 
Sbjct: 495 GQERPGVARKEPARAEAPRKTEKEAKTPRELKKDPKPSVSRTQPREVRRAASSVPNLKKT 554

Query: 228 GSQACPADR-GPA---NGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLS 283
            +QA P  R  P+   +G PP      SPPS              AS PSA         
Sbjct: 555 NAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGE---------ASPPSAAC------- 598

Query: 284 PKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSAL 343
                                 SP +   A     L  + A E +A E P     +P   
Sbjct: 599 ---------------------GSPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPR 637

Query: 344 AGMQDLR---LEGALHLLLAQQQLRARARAGSVRPRGQPT---PGEMLPSLP--VGSDSE 395
               +      EG+  L L+        R G   P   PT   P    PSLP  VGS   
Sbjct: 638 TPSPESHRSPAEGSERLSLSP------LRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHS 691

Query: 396 GPENEGTRAALA-----AAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRA 450
              +E    +       +A  S    + P    RA+R+ +    D  L  P +     R 
Sbjct: 692 TEVDESLSVSFEQVLPPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLVSPCEFEH--RK 749

Query: 451 RGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPM 510
                P PA      SP +++ +S     ++G L         G + T      E+   +
Sbjct: 750 AVPMAPAPA------SPGSSNDSSARSQERAGGL---------GAEETPPTSVSESLPTL 794

Query: 511 DPSRPLPGSQLSLSSPGSTEDEDTGR--PLPPPHPQPPPHPQPPDL-DGHPEPSKAEVLR 567
             S P+P +  +  S   TE     R  PLP P   PPP P P  +    PE    +  R
Sbjct: 795 SDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTAR 854

Query: 568 PESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKA- 626
            +++ +  T  P +     + A   T       + +   +    P   R   SE G +A 
Sbjct: 855 -QTENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAP 913

Query: 627 -SKKPSRGRRKLTATEGP-GSPRDAEDHSPSPNSSP 660
            S+K S  +   TAT GP GS       S +P  SP
Sbjct: 914 LSRKSSTPK---TATRGPSGSASSRPGVSATPPKSP 946


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 104/490 (21%), Positives = 175/490 (35%), Gaps = 68/490 (13%)

Query: 113  EENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEED 172
            ++ +T +  +  +R+L     P  K   ++P   LL+PS       T K  G  ++    
Sbjct: 2265 DDGDTGRIPLSHIRLL----PPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDG--- 2317

Query: 173  HQGVGLRGEEKPA------GHRTSPVAKISPGATLPESRAPDMSPQR-ISNQLHGTIAVV 225
                G  G E+P       G + S  AK    ATL E    D  P   ++ +   T    
Sbjct: 2318 ----GTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSST---- 2369

Query: 226  RPGSQACPADRGPANGTPP---PLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKL 282
             PGS+  P +        P   P P + SP  PA+    + + F     P+     AP +
Sbjct: 2370 -PGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLI 2428

Query: 283  S-------PKVDRLCLLN------RP---LSLHLQSPHSSPLAPAAAPSDPRLQDLKARE 326
            +       PK  R    +      RP     L ++  H    +P +  +   L   +   
Sbjct: 2429 TMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPG 2488

Query: 327  AEAWEEPTELLGL----PSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPG 382
            A  W+EP  LL L    P+A +         A    LAQ+         S  P+  P   
Sbjct: 2489 AGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPK-SPDKA 2547

Query: 383  EMLPSLPVGSDSEGPENEGTRAALAAAGLSG--------GRHTQPAGPGRAQRTEAAATQ 434
            +        S+S    + G+ ++ +++  SG        G      G G   R  +AA+ 
Sbjct: 2548 QAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASS 2607

Query: 435  DCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNG 494
              A       S    +    +   +    S S +++ ++S    + S   + S  + S+ 
Sbjct: 2608 RAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2667

Query: 495  TKGTRVPEQEEASTPMDPSRPL----PGSQLSLSSPGSTE-------DEDTGRPLPPPHP 543
            +  +   E    S+  D + P     P +Q +L +  + +           G+  P P P
Sbjct: 2668 SSSSTTDEDSSCSSD-DEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQP 2726

Query: 544  Q-PPPHPQPP 552
            Q PPP P  P
Sbjct: 2727 QAPPPQPTQP 2736



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 59/241 (24%), Positives = 81/241 (33%), Gaps = 47/241 (19%)

Query: 436  CALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGT 495
            CA   P  L    + R + T K  G+      A     S EP  ++    R P A + G 
Sbjct: 2288 CAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAG----SEEPGAKARGRGRKPSAKAKGD 2343

Query: 496  KGTRV----PEQEEASTPM--DPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHP 549
            +   +    P  E  STP+  +PS   PGS+    SP    D+    P   P P P P P
Sbjct: 2344 RAATLEEGNPTDEVPSTPLALEPSST-PGSK---KSPPEPVDKRAKAPKARPAP-PQPSP 2398

Query: 550  QPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHG 609
             PP     P P                            AE     T   P  + T    
Sbjct: 2399 APPAFTSCPAPEPF-------------------------AELPAPATSLAPAPLITMPAT 2433

Query: 610  QGPPRKRKRASEPGDKASKKPSRGRRKLTAT--EGPGSPRDAEDHS-----PSPNSSPWE 662
            +  P+K + A E G K  ++P      L     EG  SP+  +          P +  W+
Sbjct: 2434 RPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQ 2493

Query: 663  E 663
            E
Sbjct: 2494 E 2494



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 89/356 (25%), Positives = 122/356 (34%), Gaps = 76/356 (21%)

Query: 231 ACPADRGPANGTPPPLPARSSPPSPAYERGLSLD---------SFLRASR-PSAMTHEAP 280
           A  A R PA+G P PLP         Y  GL+L          SF+ +   PSA +H +P
Sbjct: 32  AATAGRLPASGLPGPLPPGK------YMAGLNLHPHPGEAFLGSFVASGMGPSASSHGSP 85

Query: 281 KLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAA----------PSD--PRLQDLKAREAE 328
              P           LS    +P + P+    A          PS   P    L   E  
Sbjct: 86  VPLPS---------DLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPSYLHLNHLEPP 136

Query: 329 AWEEPT-ELLGLPSALAGMQDLRLEG-ALHLLLAQQQLRARARAGSVRPRGQPTPGEMLP 386
           +   P    LG PS     +     G   +L  A       + A S R     TPG    
Sbjct: 137 SSGSPLLSQLGQPSIFDTQKGQGPGGDGFYLPTAGAPGSLHSHAPSAR-----TPG---- 187

Query: 387 SLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSE 446
               G  S G   +G+ +    A    GR  +P      +   A   +       +DL++
Sbjct: 188 ----GGHSSGAPAKGSSSRDGPAKERAGRGGEPPPLFGKKDPRARGEEASGPRGVVDLTQ 243

Query: 447 WGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKG-----TRVP 501
             RA G+    P      LSP  A     E  T++  L  S   + NG  G       V 
Sbjct: 244 EARAEGRQDRGPPRLAERLSPFLA-----ESKTKNAALQPSVLTMCNGGAGDVGLPALVA 298

Query: 502 EQ-----EEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPP 552
           E      +EA+   + +R L  ++  L  P         RP P P P PP  P+ P
Sbjct: 299 EAGRGGAKEAARQDEGARLLRRTETLLPGP---------RPCPSPLPPPPAPPKGP 345



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 31/130 (23%), Positives = 47/130 (36%), Gaps = 17/130 (13%)

Query: 135  RAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAK 194
            R K+G  +P   L  P+PG        P       E+  +   LRG ++P          
Sbjct: 1931 RPKKGLGEPGPSLAAPTPGARGPDPSSPDKAKLAVEKGRKARKLRGPKEPGFEAG----- 1985

Query: 195  ISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPS 254
                   PE+   D+  +R S ++      +   S A PA    A  T     A+  P S
Sbjct: 1986 -------PEASDDDLWTRRRSERI-----FLHDASAAAPAPVSTAPATKTSRCAKGGPLS 2033

Query: 255  PAYERGLSLD 264
            P  + G + D
Sbjct: 2034 PRKDAGRAKD 2043



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 86/344 (25%), Positives = 118/344 (34%), Gaps = 72/344 (20%)

Query: 295 PLSLHLQSP--------HSSPLAPAAAPSDPRLQDLKARE-AEAWEEPTELLGLPSALAG 345
           P SLH  +P        HSS  APA   S    +D  A+E A    EP  L G     A 
Sbjct: 173 PGSLHSHAPSARTPGGGHSSG-APAKGSSS---RDGPAKERAGRGGEPPPLFGKKDPRAR 228

Query: 346 MQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSE---------- 395
            ++    G   ++   Q+ RA  R    + RG P   E L      S ++          
Sbjct: 229 GEEA--SGPRGVVDLTQEARAEGR----QDRGPPRLAERLSPFLAESKTKNAALQPSVLT 282

Query: 396 ----GPENEGTRAALAAAGLSGGRHT--QPAGPGRAQRTEAAATQDCALDKPLDLSEWGR 449
               G  + G  A +A AG  G +    Q  G    +RTE           PL       
Sbjct: 283 MCNGGAGDVGLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLP------ 336

Query: 450 ARGQDTPKPAGQHG-----SLSPAAAHTASPE-------------PPTQSGPLTRSPQAL 491
                 P PA   G     + +PA  +T   E             P  ++      P  +
Sbjct: 337 ------PPPAPPKGPPAPPAATPAGVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQI 390

Query: 492 SNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSP-GSTEDEDTGRPLPPPHPQPPPHPQ 550
           ++  +  R  E+E A  P     P PGS   L  P G  E     R L  P P   P  +
Sbjct: 391 ASQARDARARERE-AGRPGVLQAP-PGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVR 448

Query: 551 PPDLDGHPE---PSKAEVLRPESDELDETDTPGSEVGLSSQAEA 591
                  P    P+K E+L+PE+D       P    G ++Q  A
Sbjct: 449 ATRASPDPRAYVPAK-ELLKPEADPRPCERAPRGPAGPAAQQAA 491



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 73/327 (22%), Positives = 104/327 (31%), Gaps = 74/327 (22%)

Query: 380  TPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALD 439
            TP  + PS   GS    PE    RA    A        +PA P  +    A  +  C   
Sbjct: 2360 TPLALEPSSTPGSKKSPPEPVDKRAKAPKA--------RPAPPQPSPAPPAFTS--CPAP 2409

Query: 440  KPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTR 499
            +P            + P PA    SL+PA   T    P T+  P  ++  A  +G KG R
Sbjct: 2410 EPF----------AELPAPAT---SLAPAPLITM---PATRPKP-KKARAAEESGAKGPR 2452

Query: 500  VP----------EQEEASTPM------------DPSR---PLPGSQLSLSS-PGSTEDED 533
             P          + E  ++P             DP       P S LSL S P +    +
Sbjct: 2453 RPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSE 2512

Query: 534  TGRPLPPPHP-----QPPPHPQPPDLDGHPEPSKAEVLR--PESDELDETDTPGSEVGLS 586
               P P         +P P     D      P KA+  +   E  E   + + GS    S
Sbjct: 2513 PKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSS 2572

Query: 587  SQAEATTSTTGE--------------GPECICTQEHGQGPPRKRKRASEPGDKASKKPSR 632
            S + + + T GE              G  C         P      +S     +S   S 
Sbjct: 2573 SSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSS 2632

Query: 633  GRRKLTATEGPGSPRDAEDHSPSPNSS 659
                 +++    S   +   S S +SS
Sbjct: 2633 SSSSSSSSSSSSSSSSSSSSSSSSSSS 2659



 Score = 30.8 bits (68), Expect = 4.2
 Identities = 37/142 (26%), Positives = 52/142 (36%), Gaps = 30/142 (21%)

Query: 443  DLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPE 502
            ++ E G  RG +    AG           TA P      G L R P  L+ G  GT    
Sbjct: 945  EMEEKGSKRGLEAAGKAG---------LATAGP------GLLPRKPPGLAAGPAGT---- 985

Query: 503  QEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRP-------LPPPHPQPPPHPQPPDLD 555
              +A +P  P  P      +L +    + ED  +P        P  HP  PP   PP   
Sbjct: 986  YGKAVSP--PPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPTSPPPASPPPTP 1043

Query: 556  G--HPEPSKAEVLRPESDELDE 575
            G    E +   V+  +  EL++
Sbjct: 1044 GITRKEEAPENVVEKKDLELEK 1065



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 47/204 (23%), Positives = 65/204 (31%), Gaps = 31/204 (15%)

Query: 227 PGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKV 286
           PG + CP+        PPP P +  P  PA         F    R   +   AP   P V
Sbjct: 326 PGPRPCPSPL-----PPPPAPPKGPPAPPAATPAGVYTVFREQGREHRVV--APTFVPSV 378

Query: 287 DRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGM 346
           +                   P+  A+   D R ++ +A      + P    G P  L   
Sbjct: 379 EAF------------DERPGPIQIASQARDARAREREAGRPGVLQAPP---GSPRPLDRP 423

Query: 347 QDLRLEGALHLLLAQ----QQLRARARAGSVRPRGQPTPGEML----PSLPVGSDSEGPE 398
           + LR + ++   L +         RA   S  PR      E+L       P      GP 
Sbjct: 424 EGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPEADPRPCERAPRGPA 483

Query: 399 NEGTRAALAAAGLSGGRHTQPAGP 422
               + A    GL  GR   P GP
Sbjct: 484 GPAAQQAAKLFGLEPGR-PPPTGP 506


>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
          Length = 819

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/384 (23%), Positives = 130/384 (33%), Gaps = 25/384 (6%)

Query: 275 MTHEAPKLSPKVDRLC--LLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEE 332
           + H    ++ K+  +C  + +    LH      +P  P  A   P + D +A     W E
Sbjct: 39  LLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAP-GPGGADGVPHI-DTQA----GWPE 92

Query: 333 PTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGS 392
             EL+      A     RLE    ++ A    RA A  G+   + +     M   +P   
Sbjct: 93  VLELVRAMQQDAAQHGARLEALFRMVAAVD--RAIALVGATFQKSKVADFLMQGRVPWRR 150

Query: 393 DSEGPENEGTRAALAAAG-------LSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLS 445
            S G   E  +  +   G        + G  +    PG   +             P+  S
Sbjct: 151 GSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRAS 210

Query: 446 EWGRARGQDTPKPAGQHGSLSPAAA---HTASPEPPTQSGPLTRSPQALSNGTKGTRVPE 502
             G    Q    P    G   PA A   H   P       P T S + L  G +    P 
Sbjct: 211 GLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPS-ENLRTGLELAPAPG 269

Query: 503 QEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSK 562
           +    +P     P  G   S S P     E+  R  P P PQ P  P  P        S 
Sbjct: 270 RVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLP-AQARATHSG 328

Query: 563 AEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEP 622
            E     S  + E DTPG E+ ++ +     + T E P     Q   QGPP   +    P
Sbjct: 329 GETPPRISIHIQEMDTPG-EMLMTGRGSLGPTLTTEAPAA--AQPGKQGPPGTGRCLQAP 385

Query: 623 GDKASKKPSRGRRKLTATEGPGSP 646
           G +  ++   G R+L+  +   SP
Sbjct: 386 GTEPGEQTPEGARELSPLQESSSP 409


>gi|169658367 BAH domain and coiled-coil containing 1 [Homo sapiens]
          Length = 2608

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 125/541 (23%), Positives = 192/541 (35%), Gaps = 100/541 (18%)

Query: 130  DRPKPRAKEGTSDPPSPLLLP----SPGGWKAITEKPPGGHEEAEEDHQG-VGLRGEEKP 184
            +R +   ++G S   S  +L     SPG  +   E+P    +E EED  G   +   E+ 
Sbjct: 1184 ERSREEGEQGPSSGASSQVLEQRAGSPGALEDEGEQPAPEEDELEEDELGQQSMEDSEED 1243

Query: 185  AGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPP 244
             G           GA  P++  P  +   +   +  TI +    S + P  + PA   PP
Sbjct: 1244 CG-----------GA--PDNSHPPRALPGLDALVAATINLGDLPSDSPPDPQPPAASGPP 1290

Query: 245  ---PLPARSSPPSPAYERGLS-LDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHL 300
               PLP  S     A    L+ L    + S  +    E   L+  +  L  L    SL  
Sbjct: 1291 STVPLPHSSGIHGIALLSELADLAIQRQRSERTVPEEEEDVLAFNLQHLATLATAWSLVE 1350

Query: 301  QSPHSSPLAPAAAPS---------DPRLQDLKARE-------------AEAWEEPTELLG 338
             +   S  APA  P+          PR+Q L+ ++             A      T+ +G
Sbjct: 1351 AAGLDSSTAPAQPPTANPCSGPRLTPRMQILQRKDTWTPKTKPVCPLKAAIDRLDTQEVG 1410

Query: 339  LPSALAGMQDLRLEGALHLLLAQ--------QQLRARARAGSVRPRGQPTPGEMLPSLPV 390
            +   LA +Q    E    L   Q        +  R+ AR G  RPR +     +    P 
Sbjct: 1411 MRVRLAELQRRYKEKQRELARLQRKHDHERDESSRSPARRGPGRPRKRKHSSSLPAPRPT 1470

Query: 391  G----SDSEGPENEGTRAALAAAGLSGGRHTQPAGP-GRAQRTEAAATQDCALDKPLDLS 445
            G    SD +  +   T   L  A L GG   +PA    + +R+  A  Q  +++K     
Sbjct: 1471 GPLPRSDGKKVKAVRTSLGLLCAELRGGSGGEPAKKRSKLERSVYAGLQTASVEKA---- 1526

Query: 446  EWGRARGQDTPKPAGQHGSLSPAAAH-TASPEPPTQSGPLTRSPQALSNGTKGTRVPEQE 504
                       K +   G L+P+ AH  A  +P  +S  L   P  LS+         Q+
Sbjct: 1527 ---------QCKKSSCQGGLAPSVAHRVAQLKPKVKSKGL---PTGLSS--------FQQ 1566

Query: 505  EASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPH--PQPPDLDGHPEPSK 562
            + +TP    R       S    G+T            HPQP  H   + P     P  + 
Sbjct: 1567 KEATPGGRIREKLSRAKSAKVSGATR-----------HPQPKGHGSRETPRCPAQPSVAA 1615

Query: 563  AEVLRPESDELD-----ETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRK 617
            ++      D  D      T+ P  E GL     A+ +  G  P  +   E  Q   +K++
Sbjct: 1616 SQEAGNGYDSEDCEGLLGTEAPPREAGLLLHTGASVAVLGPSPSSVVKMEANQKAKKKKE 1675

Query: 618  R 618
            R
Sbjct: 1676 R 1676



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 129/557 (23%), Positives = 183/557 (32%), Gaps = 91/557 (16%)

Query: 161  KPPGGHEEAEEDHQGVGLRGEEKP------AGHRTSPVA---KISPGATLPESRAPDMSP 211
            KP   H + EE  Q    +   KP      A    SP A   K+ P    P+ + P  SP
Sbjct: 947  KPEDQHLDLEEPAQEKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHPPDPKPPASSP 1006

Query: 212  Q---RISNQLHGTIAVVR---PGSQACPADRGPANGTPPPLPARSSPPS--PAYER---- 259
                R S      +       PGS+   A+     G        +S P   P Y R    
Sbjct: 1007 TPPPRPSAPCTLNVCPASSPGPGSRVRSAEEKNGEGQQSTADIITSEPDLPPGYLRPMAG 1066

Query: 260  -GLSLDSFLRASR---PSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPS 315
             G SL S + +S    P  M   AP   P+  R  L   P     +S     L   A  +
Sbjct: 1067 LGFSLPSDVHSSNLEDPETMQTTAPGAQPEPTRTFLPGEPPPCSPRSLEEPGLLSGAREA 1126

Query: 316  DPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRP 375
                QDL A        P      PS L G+Q+L+    L     +   +A +  G  R 
Sbjct: 1127 T---QDLAATPYPTERGPQGKAADPSPLEGLQELQCAALLEAGGPEATGQAHSTQGGARE 1183

Query: 376  RGQPTPGEMLPSLPVGSDSEGPENE-GTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQ 434
                  GE  PS   G+ S+  E   G+  AL   G       QPA P   +  E    Q
Sbjct: 1184 ERSREEGEQGPS--SGASSQVLEQRAGSPGALEDEG------EQPA-PEEDELEEDELGQ 1234

Query: 435  DCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTA--------SPEPPTQSGPLTR 486
                D   D    G       P+      +L  A  +           P+PP  SGP + 
Sbjct: 1235 QSMEDSEEDCG--GAPDNSHPPRALPGLDALVAATINLGDLPSDSPPDPQPPAASGPPST 1292

Query: 487  SPQALSNGTKG------------------TRVPEQEEASTPMDPSRPLPGSQLSLSSPGS 528
             P   S+G  G                    VPE+EE     +  + L     + S   +
Sbjct: 1293 VPLPHSSGIHGIALLSELADLAIQRQRSERTVPEEEEDVLAFN-LQHLATLATAWSLVEA 1351

Query: 529  TEDEDTGRPLPPPHPQPPPHPQ-PPDLD----GHPEPSKAEVLRPESDELDETDTPGSEV 583
               + +  P  PP   P   P+  P +           K + + P    +D  DT   EV
Sbjct: 1352 AGLDSSTAPAQPPTANPCSGPRLTPRMQILQRKDTWTPKTKPVCPLKAAIDRLDT--QEV 1409

Query: 584  GLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGP 643
            G+  +                 +E  +   R +++     D++S+ P+R         GP
Sbjct: 1410 GMRVRLAELQRR---------YKEKQRELARLQRKHDHERDESSRSPAR--------RGP 1452

Query: 644  GSPRDAEDHSPSPNSSP 660
            G PR  +  S  P   P
Sbjct: 1453 GRPRKRKHSSSLPAPRP 1469



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 77/298 (25%), Positives = 104/298 (34%), Gaps = 65/298 (21%)

Query: 426  QRTEAAATQDCALDKPLDLSEWGRARG-QDTPKPAG----QHGSLSPAAAHTASPE---- 476
            Q+  AA  Q    D+ LDL E  + +  + T KP        G+ SPAA  T  P     
Sbjct: 937  QQQRAAQFQRKPEDQHLDLEEPAQEKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHP 996

Query: 477  ------------PPTQSGPLTRSPQALSNGTKGTRVPEQEEAS----------------T 508
                        PP  S P T +    S+   G+RV   EE +                 
Sbjct: 997  PDPKPPASSPTPPPRPSAPCTLNVCPASSPGPGSRVRSAEEKNGEGQQSTADIITSEPDL 1056

Query: 509  PMDPSRPLPGSQLSLSS---PGSTEDEDTGRPLPP-PHPQP-----PPHPQPPDLDGHPE 559
            P    RP+ G   SL S     + ED +T +   P   P+P     P  P P       E
Sbjct: 1057 PPGYLRPMAGLGFSLPSDVHSSNLEDPETMQTTAPGAQPEPTRTFLPGEPPPCSPRSLEE 1116

Query: 560  PSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTG------------EGPECICTQE 607
            P      R  + +L  T  P +E G   +A   +   G             GPE      
Sbjct: 1117 PGLLSGAREATQDLAATPYP-TERGPQGKAADPSPLEGLQELQCAALLEAGGPEATGQAH 1175

Query: 608  HGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAED--HSPSPNSSPWEE 663
              QG  R+ +R+ E G++    PS G       +  GSP   ED    P+P     EE
Sbjct: 1176 STQGGARE-ERSREEGEQG---PSSGASSQVLEQRAGSPGALEDEGEQPAPEEDELEE 1229



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 33/114 (28%), Positives = 42/114 (36%), Gaps = 7/114 (6%)

Query: 167 EEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVR 226
           E     H+         PAG    P A   PG   P S  P M+    S++L G+     
Sbjct: 15  ERGSLGHRSAAAAARLAPAGPAAQPPAHFQPGKYFP-SPLP-MASHTASSRLMGSSPASS 72

Query: 227 PGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAP 280
                  +  G A  T P  P+ SSPP  AY       S +  S     +HEAP
Sbjct: 73  FMGSFLTSSLGSAASTHPSGPS-SSPPEQAYRGSHPTTSQIWFSH----SHEAP 121


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
           sapiens]
          Length = 2524

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 49/205 (23%), Positives = 78/205 (38%), Gaps = 18/205 (8%)

Query: 450 ARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTP 509
           A G + P+     G  S  A  T +    T+S P   +  A   G  G + P    A  P
Sbjct: 726 ASGNEVPR-----GECSGPA--TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGP 778

Query: 510 MDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPE 569
                  P   +   +  +   E TG P PP  P PP    PP +    E  +     P 
Sbjct: 779 PPGPPTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPP 836

Query: 570 SDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPR----KRKRASEPGDK 625
            +E +E   P +E     +    T    E  +  CT+E  +GP +    +   A+  G  
Sbjct: 837 VEEGEEQKPPAAE-----ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGAL 891

Query: 626 ASKKPSRGRRKLTATEGPGSPRDAE 650
            ++K   G  + T  +  G+P+D++
Sbjct: 892 KAEKKEGGSGRATTAKSSGAPQDSD 916



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 107/471 (22%), Positives = 149/471 (31%), Gaps = 101/471 (21%)

Query: 107  EMNGLKEENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGH 166
            E +G+    E + EE + L   G+   PR   G    P+ +   S       TE  P  H
Sbjct: 706  EASGVSGNEEEMVEEAEALHASGNEV-PR---GECSGPATVNNSSD------TESIPSPH 755

Query: 167  EEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVR 226
             EA +D    G  G + PA          + GA  P    P   P+ I      T     
Sbjct: 756  TEAAKD---TGQNGPKPPA----------TLGADGPPPGPPTPPPEDIPAPTEPT----- 797

Query: 227  PGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKV 286
                  PA       TPPP P   S P P   +    +    A+ P     E  K  P  
Sbjct: 798  ------PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEE--TAAAPPVEEGEEQK-PPAA 848

Query: 287  DRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGM 346
            + L +         + P  S     A     + +D +A EA A                 
Sbjct: 849  EELAVDTG----KAEEPVKSECTEEAEEGPAKGKDAEAAEATA----------------- 887

Query: 347  QDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAAL 406
                 EGAL    A+++     RA + +  G P   +   +       E    +  R   
Sbjct: 888  -----EGALK---AEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLS 939

Query: 407  AAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLS 466
                L       P G  RA         + +  KPLDL +  +      P     H    
Sbjct: 940  PRPSL-----LTPTGDPRA---------NASPQKPLDLKQLKQRAAAIPPIVTKVHEPPR 985

Query: 467  PAAAHT----ASPEPPTQSGPLTRSPQALSNGTKG----TRVPEQEEASTPM-DPSRPLP 517
              AA T     +P PP    P + +PQ   +  +G       P  +EA  P+  P+    
Sbjct: 986  EDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAE 1045

Query: 518  GSQLSLSSPGSTEDEDTGRPLP-PPHPQPPPHPQPPDLD-------GHPEP 560
              +L    PG      +G P P PP       P  PD         GHP P
Sbjct: 1046 AQKL----PGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLP 1092



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 135/656 (20%), Positives = 214/656 (32%), Gaps = 188/656 (28%)

Query: 28   ELNSERCRDAQRIEELFS-----KNHQLREQQKTLKENLRVLENRLRAGLCDRCMVTQEL 82
            E NSE     Q+  EL S      +    E+ +T K+ L  LE+        R + ++ +
Sbjct: 589  EANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGL--LEHGRNWSAIARMVGSKTV 646

Query: 83   ARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRVLGDRPKPRAKEGTSD 142
            ++ +   F     QNL  I     + + LK E E      K+      +    A E  + 
Sbjct: 647  SQCKNFYFNYKKRQNLDEIL----QQHKLKMEKERNARRKKK------KAPAAASEEAAF 696

Query: 143  PPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLP 202
            PP           +       G  EE  E+ + +   G E P G  + P       AT+ 
Sbjct: 697  PPVV------EDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGP-------ATV- 742

Query: 203  ESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPP--LPARSSPPSPAYERG 260
                         N    T ++  P ++A   D G  NG  PP  L A   PP P     
Sbjct: 743  -------------NNSSDTESIPSPHTEAAK-DTGQ-NGPKPPATLGADGPPPGP----- 782

Query: 261  LSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQ 320
                       P+    + P  +           P S    +P + P AP +  + P + 
Sbjct: 783  -----------PTPPPEDIPAPTEPT--------PASEATGAP-TPPPAPPSPSAPPPVV 822

Query: 321  DLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPT 380
              + +E E    P    G        ++L ++        + +    A  G  +      
Sbjct: 823  PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAK------ 876

Query: 381  PGEMLPSLPVGSDSEGPENEGTRAALAAAGLSG-GRHTQPAGPGRAQRTEAAATQDCALD 439
                      G D+E  E     A  A     G GR T     G  Q ++++AT  C+ D
Sbjct: 877  ----------GKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSAT--CSAD 924

Query: 440  KPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTR 499
            + +D +E G      +P+P+    +  P A   ASP+ P     L +   A+        
Sbjct: 925  E-VDEAEGGDKNRLLSPRPSLLTPTGDPRA--NASPQKPLDLKQLKQRAAAIPPIVTKVH 981

Query: 500  VPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPE 559
             P +E+A+    P++P P                       P P PP + QP        
Sbjct: 982  EPPREDAA----PTKPAP-----------------------PAPPPPQNLQP-------- 1006

Query: 560  PSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRA 619
                           E+D P                          Q+ G  P  K +  
Sbjct: 1007 ---------------ESDAP--------------------------QQPGSSPRGKSRSP 1025

Query: 620  SEPGDKASKKP------SRGRRKLTA-----TEG---PGSPRD---AEDHSPSPNS 658
            + P DK ++KP      +   +KL       T G   P  PR+   A  H+P P++
Sbjct: 1026 APPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSA 1081


>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
          Length = 1312

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 100/434 (23%), Positives = 156/434 (35%), Gaps = 77/434 (17%)

Query: 233 PADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLL 292
           P+   P+   PPP PA  +PP+P ++             P   T EA    P  ++    
Sbjct: 201 PSSSSPSPPPPPPPPAPPAPPAPRFD----------IYDPFHPTDEAYSPPPAPEQKYDP 250

Query: 293 NRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLE 352
             P         S+P + A  PS    ++ +  E E  E+  E  GL  +++ + +  L 
Sbjct: 251 FEPTG-------SNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISE-TLA 302

Query: 353 GALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRA--ALAAAG 410
           G        Q         S RP  QPT     P  P       P+ + TRA  A+    
Sbjct: 303 GIYDDNSLSQDFPGDE---SPRPDAQPTQPTPAPGTP-------PQVDSTRADGAMRRRV 352

Query: 411 LSGGRHTQPAGPGRAQRTEAAATQDCALDKPL------DLSEWGRARGQDTP-------K 457
              G   +    G+    E       AL  PL      ++ E    + ++ P       +
Sbjct: 353 FVVGTEAEACREGKVS-VEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFR 411

Query: 458 PAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQ--------ALSNGTKGTRVPEQEEASTP 509
           P G+    +PAA+ T + +P  Q  P  R+P+        A S+G    +V   E A  P
Sbjct: 412 PGGRAARPTPAASATPTAQPLPQP-PAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAP 470

Query: 510 MDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPE 569
             P+       L L     T+  +  R      P P P P P    G P   K+   R  
Sbjct: 471 --PAADSRWGGLDLRRKILTQRRERYR---QRSPSPAPAPAPAAAAGPPTRKKSRRERKR 525

Query: 570 SDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKAS-- 627
           S E             + +A +++S T   P    +    +   + R R  +PG  AS  
Sbjct: 526 SGE-------------AKEAASSSSGTQPAPPAPASPWDSK---KHRSRDRKPGSHASSS 569

Query: 628 -KKPSRGRRKLTAT 640
            ++ SR R +  +T
Sbjct: 570 ARRRSRSRSRSRST 583



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 44/184 (23%), Positives = 67/184 (36%), Gaps = 16/184 (8%)

Query: 485 TRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQ 544
           T SPQ  SN ++ T        +    P+ P P    + SSP  +    +  P PPP P 
Sbjct: 159 TVSPQ--SNSSRPTCARHLTLGTGDGGPAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPP 215

Query: 545 PPPHPQPPDLDGHP--EPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPEC 602
            PP P  P  D +    P+      P + E  +   P    G +  + A T +  E    
Sbjct: 216 APPAPPAPRFDIYDPFHPTDEAYSPPPAPE--QKYDPFEPTGSNPSSSAGTPSPEE---- 269

Query: 603 ICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRD--AEDHSPSPNSSP 660
              +E  +    + +   E  +  S+  SR    L       S       D SP P++ P
Sbjct: 270 ---EEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQP 326

Query: 661 WEET 664
            + T
Sbjct: 327 TQPT 330



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 37/152 (24%), Positives = 49/152 (32%), Gaps = 33/152 (21%)

Query: 448 GRARGQDTPKPAGQHGSLSPA-AAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEA 506
           G   G   P PA    S SP+ +  ++SP PP    P                       
Sbjct: 178 GTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPP----------------------- 214

Query: 507 STPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHP---QPPDLDGHPEPSKA 563
             P  P+ P P  +  +  P    DE    P  P     P  P    P    G P P + 
Sbjct: 215 --PAPPAPPAP--RFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEE 270

Query: 564 EVLRPESDELDETDTPGSEVGLSSQAEATTST 595
           E    E +E +E +    E GLS      + T
Sbjct: 271 E--EEEEEEEEEEEDEEEEEGLSQSISRISET 300



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 99/457 (21%), Positives = 153/457 (33%), Gaps = 71/457 (15%)

Query: 247  PARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDR-LCLLNRPLSLHLQSPHS 305
            PA + PPS +   G   DS  R + P       P +    D  L  + R +++  +   S
Sbjct: 663  PAPAPPPSGSTSCG-DRDSRRRGAVP-------PSIQDLTDHDLFAIKRTITVG-RLDKS 713

Query: 306  SPLAPAAAP-SDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQL 364
             P  P+ AP S P+ + L   E  + EE           +  +D R  GA     + ++ 
Sbjct: 714  DPRGPSPAPASSPKREVLYDSEGLSGEER-------GGKSSQKDRRRSGAASSSSSSREK 766

Query: 365  RARARA--GSVRPRGQPT-------------PGEMLPSLPVGSDSEGPENEGTRAALAAA 409
             +R +A  G  R R +               P E  PS   G   + P + G+ ++ +++
Sbjct: 767  GSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSS--GPPPKPPVSSGSGSSSSSS 824

Query: 410  GLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGR--ARGQDTPKPAGQHGSLSP 467
              S  +    +      R   ++T          L   G   +R +++  P  +    +P
Sbjct: 825  SCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAP 884

Query: 468  AAAHTASP--EPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLS- 524
                 A+P    P ++    ++    + GTKG   P +              G Q+SL  
Sbjct: 885  TEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKK 944

Query: 525  -----------SPGSTEDEDTGRP-------LPPPHPQPPPHPQPPDLDGHPEPSKAEVL 566
                       + G+ E   +G          PPP   PPP    PD        K    
Sbjct: 945  SKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKT--- 1001

Query: 567  RPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKA 626
             PE   L E  T   E G+   AE       E  E    +E  +  P      S      
Sbjct: 1002 -PEVSFLPEEAT--EEAGVRGGAEEEEEEEEEEEE---EEEEEEQQPATTTATSTAAAAP 1055

Query: 627  SKKPSRGRR--KLTATEGPGSPRDAEDHSPSPNSSPW 661
            S  PS G       A +GP S        P P   PW
Sbjct: 1056 STAPSAGSTAGDSGAEDGPASRVSQLPTLPPP--MPW 1090


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 106/498 (21%), Positives = 159/498 (31%), Gaps = 42/498 (8%)

Query: 181 EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240
           E+  +   T  + K S     P S+       +      G  A+  P        + PA+
Sbjct: 168 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-ALTTPKEPTPTTPKEPAS 226

Query: 241 GTPP-PLP-----ARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
            TP  P P     A ++P  PA     S  +  +   P+     AP  +PK         
Sbjct: 227 TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT-TPKEPAPTTTKE 285

Query: 295 PLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEG 353
           P     +S  ++P  PA   P  P     K       +EPT     P+          E 
Sbjct: 286 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT-----PTTPKEPAPTTKEP 340

Query: 354 ALHLLLAQQQLRARARAGSVRPRGQPT-PGEMLPSL---PVGSDSEGPENEGTRAALAAA 409
           A            +  A +      PT P E  P+    P  +  + P    T++A    
Sbjct: 341 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 400

Query: 410 GLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRAR-GQDTPKPAGQHGSLSPA 468
                  T+ A P   +      T++ A   P + +     +    TPK         PA
Sbjct: 401 KEPAPTTTKSA-PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 459

Query: 469 AAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGS 528
              T  P P T   P   +P+  +  T     P   E   P  P +P P +   L+   +
Sbjct: 460 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAP--T 517

Query: 529 TEDEDTGRPLPPPHPQP-PPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSS 587
           T +E T  P  P  P P  P    P+    P P+  +   P + +     TP        
Sbjct: 518 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP-------- 567

Query: 588 QAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRKLTAT 640
             + T  TT +G      +E     P+K            EP      KP+    K TA 
Sbjct: 568 --KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 625

Query: 641 EGPGSPRDAEDHSPSPNS 658
             P  P       P+P +
Sbjct: 626 TTPKEPAPTTPKEPAPTT 643



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 109/562 (19%), Positives = 169/562 (30%), Gaps = 46/562 (8%)

Query: 114 ENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           E  + K+     +VL  +P P+A+  T  P     L +P      T K P      E   
Sbjct: 180 EKTSAKDLAPTSKVLA-KPTPKAETTTKGPA----LTTPKEPTPTTPKEPASTTPKEPTP 234

Query: 174 QGVGLRG----EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGS 229
             +        E  P   +++P     P  T  +  AP    +                +
Sbjct: 235 TTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA 294

Query: 230 QACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRL 289
              P +  P   T P  PA ++P  PA        +      P+  T E    +PK    
Sbjct: 295 PTTPKEPAP---TTPKKPAPTTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAP 350

Query: 290 CLLNRPLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQD 348
               +P         ++P  PA   P +P     K       +EP      P+       
Sbjct: 351 TAPKKPAP-------TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPA-----PTTTKSAPT 398

Query: 349 LRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAA 408
              E A     +           + +     TP E  P+ P       P+          
Sbjct: 399 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 458

Query: 409 AGLSGGRH--TQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGS-L 465
           A  +  +   T P  P      E A T      K L  +   +       KPA      L
Sbjct: 459 APTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEEL 514

Query: 466 SPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGS--QLSL 523
           +P      +P  P +  P T  P+A +  T     P   +   P  P  P P +  + + 
Sbjct: 515 APTTPEEPTPTTPEEPAPTT--PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 572

Query: 524 SSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEV 583
           ++P  T       P P    +P P    P     P  +  +   P + +     TP    
Sbjct: 573 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 632

Query: 584 GLSSQAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRK 636
             + +  A T+  G  P  +  +E     P+K             P    S KP+    K
Sbjct: 633 PTTPKEPAPTTPKGTAPTTL--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 690

Query: 637 LTATEGPGSPRDAEDHSPSPNS 658
            TA   P  P       P+P +
Sbjct: 691 ETAPTTPKEPAPTTPKKPAPTT 712



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/278 (21%), Positives = 91/278 (32%), Gaps = 32/278 (11%)

Query: 386 PSLPVGSD-SEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDL 444
           PSLP  SD S+       +        +   + Q +  G+ + T A  TQ        DL
Sbjct: 128 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 187

Query: 445 SEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQE 504
           +   +   + TPK   +  +  PA      P P T   P + +P+  +  T         
Sbjct: 188 APTSKVLAKPTPK--AETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI-------- 237

Query: 505 EASTPMDPSRPLPGSQLSL-SSPGSTEDEDTGRPLP--PPHPQPPPHPQPPDLDGHPEPS 561
             S P  P  P P +  S  ++P       T  P P  P  P P    +P        P+
Sbjct: 238 -KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 296

Query: 562 KAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASE 621
             +   P + +     TP  E   ++  E T +T                P        E
Sbjct: 297 TPKEPAPTTPKKPAPTTP-KEPAPTTPKEPTPTT----------------PKEPAPTTKE 339

Query: 622 PGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSS 659
           P     K+P+    K  A   P  P       P+P ++
Sbjct: 340 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 377



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 93/429 (21%), Positives = 136/429 (31%), Gaps = 48/429 (11%)

Query: 190 SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPAR 249
           SP     P  T P+  AP  +P++ +       A   P   A    + PA  TP   PA 
Sbjct: 419 SPTTTKEPAPTTPKEPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-PAP 476

Query: 250 SSPPSPAYERGLSLDSFLRASRPSAMTHEAP-KLSPKVDRLCLLNRPLSLHLQSPHS--- 305
           ++P   A             + P  +T   P KL+P          P  L   +P     
Sbjct: 477 TTPKETA------------PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 524

Query: 306 ------SPLAP-AAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLL 358
                 +P  P AAAP+ P+       +  A   P E    P+          +G     
Sbjct: 525 TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE--PAPTTPKETAPTTPKGTAPTT 582

Query: 359 LAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQ 418
           L +             P+ +P P E+ P+      S   +          A  +  +   
Sbjct: 583 LKEP--------APTTPK-KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP-KEPA 632

Query: 419 PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPA-GQHGSLSPAAAHTASPE- 476
           P  P     T    T    L +P   +    A  +  P    G   + S   A T   E 
Sbjct: 633 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 692

Query: 477 -PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTG 535
            P T   P   +P+  +  T  T  P   E STP     P    +    SP  +  E + 
Sbjct: 693 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK----SPDESTPELSA 748

Query: 536 RPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETD---TPGSEVGLSSQAEAT 592
            P P      P  P  P     P  +K E+     D+  E D   TP +        + T
Sbjct: 749 EPTPKALENSPKEPGVPTTK-TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKET 807

Query: 593 TSTTGEGPE 601
            +TT +  E
Sbjct: 808 ATTTEKTTE 816



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 47/221 (21%), Positives = 73/221 (33%), Gaps = 20/221 (9%)

Query: 455 TPKPAGQHGSLSPAA------AHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEAST 508
           T KP     SL P +      + T + E   ++   T + +  S   K      +E  S 
Sbjct: 120 TAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSI 179

Query: 509 PMDPSRPLPGSQLSLSSPGSTEDEDTGRP-LPPPHPQPPPHPQPPDLDGHPEPSKAEVLR 567
               ++ L  +   L+ P    +  T  P L  P    P  P+ P      EP+   +  
Sbjct: 180 EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 239

Query: 568 PESDELDETDTPGSEVGLSSQAEATTST------TGEGPECICTQEHGQGPPRKRKRA-- 619
             +   +   T       + +  A T+T      T + P    T+E     P   K A  
Sbjct: 240 APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSAPT 296

Query: 620 --SEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNS 658
              EP     KKP+    K  A   P  P       P+P +
Sbjct: 297 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 337


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 106/498 (21%), Positives = 159/498 (31%), Gaps = 42/498 (8%)

Query: 181 EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240
           E+  +   T  + K S     P S+       +      G  A+  P        + PA+
Sbjct: 209 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-ALTTPKEPTPTTPKEPAS 267

Query: 241 GTPP-PLP-----ARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
            TP  P P     A ++P  PA     S  +  +   P+     AP  +PK         
Sbjct: 268 TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT-TPKEPAPTTTKE 326

Query: 295 PLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEG 353
           P     +S  ++P  PA   P  P     K       +EPT     P+          E 
Sbjct: 327 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT-----PTTPKEPAPTTKEP 381

Query: 354 ALHLLLAQQQLRARARAGSVRPRGQPT-PGEMLPSL---PVGSDSEGPENEGTRAALAAA 409
           A            +  A +      PT P E  P+    P  +  + P    T++A    
Sbjct: 382 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 441

Query: 410 GLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRAR-GQDTPKPAGQHGSLSPA 468
                  T+ A P   +      T++ A   P + +     +    TPK         PA
Sbjct: 442 KEPAPTTTKSA-PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 500

Query: 469 AAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGS 528
              T  P P T   P   +P+  +  T     P   E   P  P +P P +   L+   +
Sbjct: 501 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAP--T 558

Query: 529 TEDEDTGRPLPPPHPQP-PPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSS 587
           T +E T  P  P  P P  P    P+    P P+  +   P + +     TP        
Sbjct: 559 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP-------- 608

Query: 588 QAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRKLTAT 640
             + T  TT +G      +E     P+K            EP      KP+    K TA 
Sbjct: 609 --KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 666

Query: 641 EGPGSPRDAEDHSPSPNS 658
             P  P       P+P +
Sbjct: 667 TTPKEPAPTTPKEPAPTT 684



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 109/562 (19%), Positives = 169/562 (30%), Gaps = 46/562 (8%)

Query: 114 ENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           E  + K+     +VL  +P P+A+  T  P     L +P      T K P      E   
Sbjct: 221 EKTSAKDLAPTSKVLA-KPTPKAETTTKGPA----LTTPKEPTPTTPKEPASTTPKEPTP 275

Query: 174 QGVGLRG----EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGS 229
             +        E  P   +++P     P  T  +  AP    +                +
Sbjct: 276 TTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA 335

Query: 230 QACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRL 289
              P +  P   T P  PA ++P  PA        +      P+  T E    +PK    
Sbjct: 336 PTTPKEPAP---TTPKKPAPTTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAP 391

Query: 290 CLLNRPLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQD 348
               +P         ++P  PA   P +P     K       +EP      P+       
Sbjct: 392 TAPKKPAP-------TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPA-----PTTTKSAPT 439

Query: 349 LRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAA 408
              E A     +           + +     TP E  P+ P       P+          
Sbjct: 440 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 499

Query: 409 AGLSGGRH--TQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGS-L 465
           A  +  +   T P  P      E A T      K L  +   +       KPA      L
Sbjct: 500 APTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEEL 555

Query: 466 SPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGS--QLSL 523
           +P      +P  P +  P T  P+A +  T     P   +   P  P  P P +  + + 
Sbjct: 556 APTTPEEPTPTTPEEPAPTT--PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 613

Query: 524 SSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEV 583
           ++P  T       P P    +P P    P     P  +  +   P + +     TP    
Sbjct: 614 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 673

Query: 584 GLSSQAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRK 636
             + +  A T+  G  P  +  +E     P+K             P    S KP+    K
Sbjct: 674 PTTPKEPAPTTPKGTAPTTL--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 731

Query: 637 LTATEGPGSPRDAEDHSPSPNS 658
            TA   P  P       P+P +
Sbjct: 732 ETAPTTPKEPAPTTPKKPAPTT 753



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/278 (21%), Positives = 91/278 (32%), Gaps = 32/278 (11%)

Query: 386 PSLPVGSD-SEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDL 444
           PSLP  SD S+       +        +   + Q +  G+ + T A  TQ        DL
Sbjct: 169 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 228

Query: 445 SEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQE 504
           +   +   + TPK   +  +  PA      P P T   P + +P+  +  T         
Sbjct: 229 APTSKVLAKPTPK--AETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI-------- 278

Query: 505 EASTPMDPSRPLPGSQLSL-SSPGSTEDEDTGRPLP--PPHPQPPPHPQPPDLDGHPEPS 561
             S P  P  P P +  S  ++P       T  P P  P  P P    +P        P+
Sbjct: 279 -KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 337

Query: 562 KAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASE 621
             +   P + +     TP  E   ++  E T +T                P        E
Sbjct: 338 TPKEPAPTTPKKPAPTTP-KEPAPTTPKEPTPTT----------------PKEPAPTTKE 380

Query: 622 PGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSS 659
           P     K+P+    K  A   P  P       P+P ++
Sbjct: 381 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 418



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 93/429 (21%), Positives = 136/429 (31%), Gaps = 48/429 (11%)

Query: 190 SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPAR 249
           SP     P  T P+  AP  +P++ +       A   P   A    + PA  TP   PA 
Sbjct: 460 SPTTTKEPAPTTPKEPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-PAP 517

Query: 250 SSPPSPAYERGLSLDSFLRASRPSAMTHEAP-KLSPKVDRLCLLNRPLSLHLQSPHS--- 305
           ++P   A             + P  +T   P KL+P          P  L   +P     
Sbjct: 518 TTPKETA------------PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 565

Query: 306 ------SPLAP-AAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLL 358
                 +P  P AAAP+ P+       +  A   P E    P+          +G     
Sbjct: 566 TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE--PAPTTPKETAPTTPKGTAPTT 623

Query: 359 LAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQ 418
           L +             P+ +P P E+ P+      S   +          A  +  +   
Sbjct: 624 LKEP--------APTTPK-KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP-KEPA 673

Query: 419 PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPA-GQHGSLSPAAAHTASPE- 476
           P  P     T    T    L +P   +    A  +  P    G   + S   A T   E 
Sbjct: 674 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 733

Query: 477 -PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTG 535
            P T   P   +P+  +  T  T  P   E STP     P    +    SP  +  E + 
Sbjct: 734 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK----SPDESTPELSA 789

Query: 536 RPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETD---TPGSEVGLSSQAEAT 592
            P P      P  P  P     P  +K E+     D+  E D   TP +        + T
Sbjct: 790 EPTPKALENSPKEPGVPTTK-TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKET 848

Query: 593 TSTTGEGPE 601
            +TT +  E
Sbjct: 849 ATTTEKTTE 857



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 47/221 (21%), Positives = 73/221 (33%), Gaps = 20/221 (9%)

Query: 455 TPKPAGQHGSLSPAA------AHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEAST 508
           T KP     SL P +      + T + E   ++   T + +  S   K      +E  S 
Sbjct: 161 TAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSI 220

Query: 509 PMDPSRPLPGSQLSLSSPGSTEDEDTGRP-LPPPHPQPPPHPQPPDLDGHPEPSKAEVLR 567
               ++ L  +   L+ P    +  T  P L  P    P  P+ P      EP+   +  
Sbjct: 221 EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 280

Query: 568 PESDELDETDTPGSEVGLSSQAEATTST------TGEGPECICTQEHGQGPPRKRKRA-- 619
             +   +   T       + +  A T+T      T + P    T+E     P   K A  
Sbjct: 281 APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSAPT 337

Query: 620 --SEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNS 658
              EP     KKP+    K  A   P  P       P+P +
Sbjct: 338 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 378


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 106/498 (21%), Positives = 159/498 (31%), Gaps = 42/498 (8%)

Query: 181 EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240
           E+  +   T  + K S     P S+       +      G  A+  P        + PA+
Sbjct: 261 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-ALTTPKEPTPTTPKEPAS 319

Query: 241 GTPP-PLP-----ARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
            TP  P P     A ++P  PA     S  +  +   P+     AP  +PK         
Sbjct: 320 TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT-TPKEPAPTTTKE 378

Query: 295 PLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEG 353
           P     +S  ++P  PA   P  P     K       +EPT     P+          E 
Sbjct: 379 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT-----PTTPKEPAPTTKEP 433

Query: 354 ALHLLLAQQQLRARARAGSVRPRGQPT-PGEMLPSL---PVGSDSEGPENEGTRAALAAA 409
           A            +  A +      PT P E  P+    P  +  + P    T++A    
Sbjct: 434 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493

Query: 410 GLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRAR-GQDTPKPAGQHGSLSPA 468
                  T+ A P   +      T++ A   P + +     +    TPK         PA
Sbjct: 494 KEPAPTTTKSA-PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 552

Query: 469 AAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGS 528
              T  P P T   P   +P+  +  T     P   E   P  P +P P +   L+   +
Sbjct: 553 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAP--T 610

Query: 529 TEDEDTGRPLPPPHPQP-PPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSS 587
           T +E T  P  P  P P  P    P+    P P+  +   P + +     TP        
Sbjct: 611 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP-------- 660

Query: 588 QAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRKLTAT 640
             + T  TT +G      +E     P+K            EP      KP+    K TA 
Sbjct: 661 --KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 718

Query: 641 EGPGSPRDAEDHSPSPNS 658
             P  P       P+P +
Sbjct: 719 TTPKEPAPTTPKEPAPTT 736



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 109/562 (19%), Positives = 169/562 (30%), Gaps = 46/562 (8%)

Query: 114 ENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           E  + K+     +VL  +P P+A+  T  P     L +P      T K P      E   
Sbjct: 273 EKTSAKDLAPTSKVLA-KPTPKAETTTKGPA----LTTPKEPTPTTPKEPASTTPKEPTP 327

Query: 174 QGVGLRG----EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGS 229
             +        E  P   +++P     P  T  +  AP    +                +
Sbjct: 328 TTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA 387

Query: 230 QACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRL 289
              P +  P   T P  PA ++P  PA        +      P+  T E    +PK    
Sbjct: 388 PTTPKEPAP---TTPKKPAPTTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAP 443

Query: 290 CLLNRPLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQD 348
               +P         ++P  PA   P +P     K       +EP      P+       
Sbjct: 444 TAPKKPAP-------TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPA-----PTTTKSAPT 491

Query: 349 LRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAA 408
              E A     +           + +     TP E  P+ P       P+          
Sbjct: 492 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 551

Query: 409 AGLSGGRH--TQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGS-L 465
           A  +  +   T P  P      E A T      K L  +   +       KPA      L
Sbjct: 552 APTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEEL 607

Query: 466 SPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGS--QLSL 523
           +P      +P  P +  P T  P+A +  T     P   +   P  P  P P +  + + 
Sbjct: 608 APTTPEEPTPTTPEEPAPTT--PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 665

Query: 524 SSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEV 583
           ++P  T       P P    +P P    P     P  +  +   P + +     TP    
Sbjct: 666 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 725

Query: 584 GLSSQAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRK 636
             + +  A T+  G  P  +  +E     P+K             P    S KP+    K
Sbjct: 726 PTTPKEPAPTTPKGTAPTTL--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 783

Query: 637 LTATEGPGSPRDAEDHSPSPNS 658
            TA   P  P       P+P +
Sbjct: 784 ETAPTTPKEPAPTTPKKPAPTT 805



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/278 (21%), Positives = 91/278 (32%), Gaps = 32/278 (11%)

Query: 386 PSLPVGSD-SEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDL 444
           PSLP  SD S+       +        +   + Q +  G+ + T A  TQ        DL
Sbjct: 221 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 280

Query: 445 SEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQE 504
           +   +   + TPK   +  +  PA      P P T   P + +P+  +  T         
Sbjct: 281 APTSKVLAKPTPK--AETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI-------- 330

Query: 505 EASTPMDPSRPLPGSQLSL-SSPGSTEDEDTGRPLP--PPHPQPPPHPQPPDLDGHPEPS 561
             S P  P  P P +  S  ++P       T  P P  P  P P    +P        P+
Sbjct: 331 -KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 389

Query: 562 KAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASE 621
             +   P + +     TP  E   ++  E T +T                P        E
Sbjct: 390 TPKEPAPTTPKKPAPTTP-KEPAPTTPKEPTPTT----------------PKEPAPTTKE 432

Query: 622 PGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSS 659
           P     K+P+    K  A   P  P       P+P ++
Sbjct: 433 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 470



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 93/429 (21%), Positives = 136/429 (31%), Gaps = 48/429 (11%)

Query: 190 SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPAR 249
           SP     P  T P+  AP  +P++ +       A   P   A    + PA  TP   PA 
Sbjct: 512 SPTTTKEPAPTTPKEPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-PAP 569

Query: 250 SSPPSPAYERGLSLDSFLRASRPSAMTHEAP-KLSPKVDRLCLLNRPLSLHLQSPHS--- 305
           ++P   A             + P  +T   P KL+P          P  L   +P     
Sbjct: 570 TTPKETA------------PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 617

Query: 306 ------SPLAP-AAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLL 358
                 +P  P AAAP+ P+       +  A   P E    P+          +G     
Sbjct: 618 TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE--PAPTTPKETAPTTPKGTAPTT 675

Query: 359 LAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQ 418
           L +             P+ +P P E+ P+      S   +          A  +  +   
Sbjct: 676 LKEP--------APTTPK-KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP-KEPA 725

Query: 419 PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPA-GQHGSLSPAAAHTASPE- 476
           P  P     T    T    L +P   +    A  +  P    G   + S   A T   E 
Sbjct: 726 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 785

Query: 477 -PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTG 535
            P T   P   +P+  +  T  T  P   E STP     P    +    SP  +  E + 
Sbjct: 786 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK----SPDESTPELSA 841

Query: 536 RPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETD---TPGSEVGLSSQAEAT 592
            P P      P  P  P     P  +K E+     D+  E D   TP +        + T
Sbjct: 842 EPTPKALENSPKEPGVPTTK-TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKET 900

Query: 593 TSTTGEGPE 601
            +TT +  E
Sbjct: 901 ATTTEKTTE 909



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 47/221 (21%), Positives = 73/221 (33%), Gaps = 20/221 (9%)

Query: 455 TPKPAGQHGSLSPAA------AHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEAST 508
           T KP     SL P +      + T + E   ++   T + +  S   K      +E  S 
Sbjct: 213 TAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSI 272

Query: 509 PMDPSRPLPGSQLSLSSPGSTEDEDTGRP-LPPPHPQPPPHPQPPDLDGHPEPSKAEVLR 567
               ++ L  +   L+ P    +  T  P L  P    P  P+ P      EP+   +  
Sbjct: 273 EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 332

Query: 568 PESDELDETDTPGSEVGLSSQAEATTST------TGEGPECICTQEHGQGPPRKRKRA-- 619
             +   +   T       + +  A T+T      T + P    T+E     P   K A  
Sbjct: 333 APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSAPT 389

Query: 620 --SEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNS 658
              EP     KKP+    K  A   P  P       P+P +
Sbjct: 390 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 430


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 106/498 (21%), Positives = 159/498 (31%), Gaps = 42/498 (8%)

Query: 181 EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240
           E+  +   T  + K S     P S+       +      G  A+  P        + PA+
Sbjct: 302 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-ALTTPKEPTPTTPKEPAS 360

Query: 241 GTPP-PLP-----ARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
            TP  P P     A ++P  PA     S  +  +   P+     AP  +PK         
Sbjct: 361 TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT-TPKEPAPTTTKE 419

Query: 295 PLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEG 353
           P     +S  ++P  PA   P  P     K       +EPT     P+          E 
Sbjct: 420 PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT-----PTTPKEPAPTTKEP 474

Query: 354 ALHLLLAQQQLRARARAGSVRPRGQPT-PGEMLPSL---PVGSDSEGPENEGTRAALAAA 409
           A            +  A +      PT P E  P+    P  +  + P    T++A    
Sbjct: 475 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534

Query: 410 GLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRAR-GQDTPKPAGQHGSLSPA 468
                  T+ A P   +      T++ A   P + +     +    TPK         PA
Sbjct: 535 KEPAPTTTKSA-PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 593

Query: 469 AAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGS 528
              T  P P T   P   +P+  +  T     P   E   P  P +P P +   L+   +
Sbjct: 594 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAP--T 651

Query: 529 TEDEDTGRPLPPPHPQP-PPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSS 587
           T +E T  P  P  P P  P    P+    P P+  +   P + +     TP        
Sbjct: 652 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP-------- 701

Query: 588 QAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRKLTAT 640
             + T  TT +G      +E     P+K            EP      KP+    K TA 
Sbjct: 702 --KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 759

Query: 641 EGPGSPRDAEDHSPSPNS 658
             P  P       P+P +
Sbjct: 760 TTPKEPAPTTPKEPAPTT 777



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 109/562 (19%), Positives = 169/562 (30%), Gaps = 46/562 (8%)

Query: 114 ENETLKEEVKRLRVLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDH 173
           E  + K+     +VL  +P P+A+  T  P     L +P      T K P      E   
Sbjct: 314 EKTSAKDLAPTSKVLA-KPTPKAETTTKGPA----LTTPKEPTPTTPKEPASTTPKEPTP 368

Query: 174 QGVGLRG----EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGS 229
             +        E  P   +++P     P  T  +  AP    +                +
Sbjct: 369 TTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA 428

Query: 230 QACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRL 289
              P +  P   T P  PA ++P  PA        +      P+  T E    +PK    
Sbjct: 429 PTTPKEPAP---TTPKKPAPTTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAP 484

Query: 290 CLLNRPLSLHLQSPHSSPLAPA-AAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQD 348
               +P         ++P  PA   P +P     K       +EP      P+       
Sbjct: 485 TAPKKPAP-------TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPA-----PTTTKSAPT 532

Query: 349 LRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAA 408
              E A     +           + +     TP E  P+ P       P+          
Sbjct: 533 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 592

Query: 409 AGLSGGRH--TQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGS-L 465
           A  +  +   T P  P      E A T      K L  +   +       KPA      L
Sbjct: 593 APTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEEL 648

Query: 466 SPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGS--QLSL 523
           +P      +P  P +  P T  P+A +  T     P   +   P  P  P P +  + + 
Sbjct: 649 APTTPEEPTPTTPEEPAPTT--PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 706

Query: 524 SSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEV 583
           ++P  T       P P    +P P    P     P  +  +   P + +     TP    
Sbjct: 707 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 766

Query: 584 GLSSQAEATTSTTGEGPECICTQEHGQGPPRK-------RKRASEPGDKASKKPSRGRRK 636
             + +  A T+  G  P  +  +E     P+K             P    S KP+    K
Sbjct: 767 PTTPKEPAPTTPKGTAPTTL--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 824

Query: 637 LTATEGPGSPRDAEDHSPSPNS 658
            TA   P  P       P+P +
Sbjct: 825 ETAPTTPKEPAPTTPKKPAPTT 846



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/278 (21%), Positives = 91/278 (32%), Gaps = 32/278 (11%)

Query: 386 PSLPVGSD-SEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDL 444
           PSLP  SD S+       +        +   + Q +  G+ + T A  TQ        DL
Sbjct: 262 PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL 321

Query: 445 SEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQE 504
           +   +   + TPK   +  +  PA      P P T   P + +P+  +  T         
Sbjct: 322 APTSKVLAKPTPK--AETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI-------- 371

Query: 505 EASTPMDPSRPLPGSQLSL-SSPGSTEDEDTGRPLP--PPHPQPPPHPQPPDLDGHPEPS 561
             S P  P  P P +  S  ++P       T  P P  P  P P    +P        P+
Sbjct: 372 -KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 430

Query: 562 KAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASE 621
             +   P + +     TP  E   ++  E T +T                P        E
Sbjct: 431 TPKEPAPTTPKKPAPTTP-KEPAPTTPKEPTPTT----------------PKEPAPTTKE 473

Query: 622 PGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSS 659
           P     K+P+    K  A   P  P       P+P ++
Sbjct: 474 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 511



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 93/429 (21%), Positives = 136/429 (31%), Gaps = 48/429 (11%)

Query: 190 SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPAR 249
           SP     P  T P+  AP  +P++ +       A   P   A    + PA  TP   PA 
Sbjct: 553 SPTTTKEPAPTTPKEPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-PAP 610

Query: 250 SSPPSPAYERGLSLDSFLRASRPSAMTHEAP-KLSPKVDRLCLLNRPLSLHLQSPHS--- 305
           ++P   A             + P  +T   P KL+P          P  L   +P     
Sbjct: 611 TTPKETA------------PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 658

Query: 306 ------SPLAP-AAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLL 358
                 +P  P AAAP+ P+       +  A   P E    P+          +G     
Sbjct: 659 TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE--PAPTTPKETAPTTPKGTAPTT 716

Query: 359 LAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQ 418
           L +             P+ +P P E+ P+      S   +          A  +  +   
Sbjct: 717 LKEP--------APTTPK-KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP-KEPA 766

Query: 419 PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPA-GQHGSLSPAAAHTASPE- 476
           P  P     T    T    L +P   +    A  +  P    G   + S   A T   E 
Sbjct: 767 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 826

Query: 477 -PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTG 535
            P T   P   +P+  +  T  T  P   E STP     P    +    SP  +  E + 
Sbjct: 827 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK----SPDESTPELSA 882

Query: 536 RPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETD---TPGSEVGLSSQAEAT 592
            P P      P  P  P     P  +K E+     D+  E D   TP +        + T
Sbjct: 883 EPTPKALENSPKEPGVPTTK-TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKET 941

Query: 593 TSTTGEGPE 601
            +TT +  E
Sbjct: 942 ATTTEKTTE 950



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 47/221 (21%), Positives = 73/221 (33%), Gaps = 20/221 (9%)

Query: 455 TPKPAGQHGSLSPAA------AHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEAST 508
           T KP     SL P +      + T + E   ++   T + +  S   K      +E  S 
Sbjct: 254 TAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSI 313

Query: 509 PMDPSRPLPGSQLSLSSPGSTEDEDTGRP-LPPPHPQPPPHPQPPDLDGHPEPSKAEVLR 567
               ++ L  +   L+ P    +  T  P L  P    P  P+ P      EP+   +  
Sbjct: 314 EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 373

Query: 568 PESDELDETDTPGSEVGLSSQAEATTST------TGEGPECICTQEHGQGPPRKRKRA-- 619
             +   +   T       + +  A T+T      T + P    T+E     P   K A  
Sbjct: 374 APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSAPT 430

Query: 620 --SEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNS 658
              EP     KKP+    K  A   P  P       P+P +
Sbjct: 431 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 471


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 123/534 (23%), Positives = 164/534 (30%), Gaps = 74/534 (13%)

Query: 163 PGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTI 222
           PG     E D   V  +G+ K  GH TS   K  PG    E++                 
Sbjct: 377 PGDTPTDEPDALYVACQGQPK-GGHVTSMQPK-EPGPLQCEAKP---------------- 418

Query: 223 AVVRPGSQACPADRGPANGTPPPLPA-RSSPPSPAYERGLSLDSFLRASRPSAMTHEAPK 281
            + + G Q  P    P N   P LP    SP SP  E             P++   EA +
Sbjct: 419 -LGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEES-----------PTSPPPEASR 466

Query: 282 LSPKVDRLCLLNRPLSLHLQSP-HSSPLAPAAAPSD----PRLQDLKAREAEAWEEPTEL 336
           LSP  + L     P +LHL  P   SPL+P    S     P        E      P E 
Sbjct: 467 LSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEES 526

Query: 337 LGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEG 396
              P+    +        L     +  L          P   P    + P       S  
Sbjct: 527 PPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSP--PPEASRLSPPPEESPMSPP 584

Query: 397 PENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTP 456
           PE         A+ L       P  P   +   +   +   L  P + S       +   
Sbjct: 585 PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPM 644

Query: 457 KPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPL 516
            P  +   LSP    +    PP +S PL+  P+           PE    S P + S   
Sbjct: 645 SPPPEVSRLSPLPVVSRLSPPPEES-PLSPPPEESPTSPP----PEASRLSPPPEDSPTS 699

Query: 517 PGSQLSLSSPGSTEDEDTGRPLP---------PPHPQPPPHPQPPDLDGHPE-----PSK 562
           P  +    SP S   ED+   LP         P  PQ  P  + P L   PE     P  
Sbjct: 700 PPPE---DSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRP 756

Query: 563 AEV-LRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASE 621
            E  L P+++E   +  P      +   E   S   EGP      E     P+  +    
Sbjct: 757 EEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLS 816

Query: 622 PGDK---ASKKPSRGRRKLTATEGPGSPRDAEDH----------SPSPNSSPWE 662
           P  +    S +P        + E   SPR  E H          SP P   P E
Sbjct: 817 PVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEE 870



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 104/436 (23%), Positives = 145/436 (33%), Gaps = 75/436 (17%)

Query: 184  PAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANG-- 241
            P   R SP  + SP +  PE       P+         ++ + P  +  P    P     
Sbjct: 621  PEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPT 680

Query: 242  TPPPLPARSSPP------SPAYERGL-------SLDSFLRASRPSAMTHEAPKLSPKVDR 288
            +PPP  +R SPP      SP  E          SL S      P     E P+L P+ + 
Sbjct: 681  SPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEG 740

Query: 289  LCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQD 348
              L  RP     + PH SP      P +P L   +A E     +P E    P   A  ++
Sbjct: 741  PHLSPRP-----EEPHLSP-----RPEEPHLSP-QAEEPHLSPQPEE----PCLCAVPEE 785

Query: 349  LRL----EGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRA 404
              L    EG  HL    ++L    +  +  P   P P E   S         P++E    
Sbjct: 786  PHLSPQAEGP-HLSPQPEELHLSPQ--TEEPHLSPVPEEPCLSPQPEESHLSPQSE--EP 840

Query: 405  ALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGS 464
             L+          +   P  + R E    +      P +L  +          P     S
Sbjct: 841  CLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLF----------PPPGEPS 890

Query: 465  LSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLS 524
            LSP     A  EP     PL+  P+ L     G   P       P DP  P     ++ +
Sbjct: 891  LSPLLGEPALSEPGEP--PLSPLPEELPLSPSGE--PSLSPQLMPPDPLPPPLSPIITAA 946

Query: 525  SP-------------GSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESD 571
            +P             G+  D D   PL  P  + P  P P      PEP    +L P   
Sbjct: 947  APPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPP--- 1003

Query: 572  ELDETDTPGSEVGLSS 587
                  +PGS VG +S
Sbjct: 1004 ------SPGSPVGPAS 1013



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 133/572 (23%), Positives = 207/572 (36%), Gaps = 110/572 (19%)

Query: 22   LQNKLLELNSERCRDAQRIEEL--FSKNHQLREQQKTLKENLRVLENRLRAGLCDRCMVT 79
            LQ  L+  + +    AQ +  L    +  QL++QQ+  ++  + L+ + +       +  
Sbjct: 3876 LQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQ-------LQQ 3928

Query: 80   QELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRVLGDRPKPRAKEG 139
            Q+L +++QQ       Q LQ+      +   L+++ + L+++ ++ +    + + + + G
Sbjct: 3929 QQLQQQQQQ-------QQLQQ-----QQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMG 3976

Query: 140  TSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGA 199
              +    LL P                ++ ++    +G     KP  H +SP A + P  
Sbjct: 3977 LLNQSRTLLSP----------------QQQQQQQVALGPGMPAKPLQHFSSPGA-LGPTL 4019

Query: 200  TLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYER 259
             L       + P   S                  A  GP+     PL   ++P S A E 
Sbjct: 4020 LLTGKEQNTVDPAVSSE-----------------ATEGPSTHQGGPLAIGTTPESMATEP 4062

Query: 260  GLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHS-SPLAPAAAPSDPR 318
            G    S    S  S +    P+  P+   L  L  PL L  Q     S L  A   S  +
Sbjct: 4063 GEVKPSL---SGDSQLLLVQPQPQPQPSSL-QLQPPLRLPGQQQQQVSLLHTAGGGSHGQ 4118

Query: 319  LQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQ 378
            L    + EA +      LL  PS   G Q   +    +LL  QQ +  R    +  P+  
Sbjct: 4119 LGSGSSSEASS---VPHLLAQPSVSLGDQPGSM--TQNLLGPQQPMLERPMQNNTGPQ-P 4172

Query: 379  PTPGEMLPSLPVGSDSEG----PENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQ 434
            P PG +L S   G    G    P     RA L    L+     +   P + Q+ +A   Q
Sbjct: 4173 PKPGPVLQS---GQGLPGVGIMPTVGQLRAQLQGV-LAKNPQLRHLSPQQQQQLQALLMQ 4228

Query: 435  -----DCALDKPLDLSEWGRARGQDTPK-------------PAGQHGSLSPAAAHTASPE 476
                   A+ +     E G    Q +P              P  Q G L    A      
Sbjct: 4229 RQLQQSQAVRQTPPYQEPGT---QTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQG 4285

Query: 477  PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGR 536
            PP    P    P ALS G     V      S+P +P RP   SQL    P  +    T  
Sbjct: 4286 PPRLPAP----PGALSTGPVLGPVHPTPPPSSPQEPKRP---SQL----PSPSSQLPTEA 4334

Query: 537  PLPPPHPQPPPHPQPPDLD---GHPEPSKAEV 565
             LPP HP   P PQ P L+   G   P+ A++
Sbjct: 4335 QLPPTHP-GTPKPQGPTLEPPPGRVSPAAAQL 4365



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 111/479 (23%), Positives = 154/479 (32%), Gaps = 87/479 (18%)

Query: 184  PAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTP 243
            P   R S V   SPG  L     P       S   H  I   RPGS   P  + P    P
Sbjct: 2330 PLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDI--FRPGSYTDPYAQPPLTPRP 2387

Query: 244  PPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSP 303
             P P  S    P   R L  D F R   P++   ++   SP      L  RPLS     P
Sbjct: 2388 QPPPPESCCALP--PRSLPSDPFSRV--PASPQSQSSSQSP------LTPRPLSAEAFCP 2437

Query: 304  HSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGAL-HLLLAQQ 362
              SP+ P     DP  +     ++    +P   L  P      +     G+L H  L   
Sbjct: 2438 --SPVTPRFQSPDPYSRPPSRPQS---RDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAG 2492

Query: 363  QLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGP 422
               A   AG          GE+   +P G       + GT A +               P
Sbjct: 2493 GFPAALPAGPA--------GELHAKVPSGQPPNFVRSPGTGAFVGT-------------P 2531

Query: 423  GRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSG 482
               + T   A  + +L  P+             P P G +    P              G
Sbjct: 2532 SPMRFTFPQAVGEPSLKPPVP--------QPGLPPPHGINSHFGP--------------G 2569

Query: 483  PLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPH 542
            P    PQ+ +N T  T       + +P+ PS    G    LS            PL PP 
Sbjct: 2570 PTLGKPQS-TNYTVAT--GNFHPSGSPLGPSSGSTGESYGLS------------PLRPPS 2614

Query: 543  PQPPPHPQP--PDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGP 600
              PPP P    P L  H    ++ +  P    +++ + PG+ +G S        T   G 
Sbjct: 2615 VLPPPAPDGSLPYL-SHGASQRSGITSP----VEKREDPGTGMGSSLATAELPGTQDPGM 2669

Query: 601  ECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATE----GPGSPRDAEDHSPS 655
              +   E  +   R+R R      +  +   R  ++  A      GP     AE  SP+
Sbjct: 2670 SGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPA 2728



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 113/476 (23%), Positives = 154/476 (32%), Gaps = 89/476 (18%)

Query: 184 PAGHRTSPVAKISPGATLPE----SRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPA 239
           P   R SP  +  P + LPE    SR  + SP             + P  +  P    P 
Sbjct: 462 PEASRLSPPPEELPASPLPEALHLSRPLEESP-------------LSPPPEESPLSPPPE 508

Query: 240 NGTPPPL------PARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLN 293
           +    PL      P   SPPSPA E  LS      AS  S    E+P LSP  + L    
Sbjct: 509 SSPFSPLEESPLSPPEESPPSPALETPLSPPP--EASPLSPPFEESP-LSPPPEELPTSP 565

Query: 294 RPLSLHLQSP-HSSPLAPAAAPSDPRLQDLKAREAEAWEE------PTEL-LGLPSALAG 345
            P +  L  P   SP++P    S        +R    +EE      P E  L  P   + 
Sbjct: 566 PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASR 625

Query: 346 MQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAA 405
           +     +  +     +  +        + P   P    + P       S  PE   T   
Sbjct: 626 LSPPPEDSPMSPPPEESPMSPPPEVSRLSPL--PVVSRLSPPPEESPLSPPPEESPTSPP 683

Query: 406 LAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEW----------GRARGQD- 454
             A+ LS      P  P       +   +D  +  PL+ S             R+ G   
Sbjct: 684 PEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHL 743

Query: 455 TPKPAGQHGSLSPAAAHTA--------SPEP---------------PTQSGP-LTRSPQA 490
           +P+P   H S  P   H +        SP+P               P   GP L+  P+ 
Sbjct: 744 SPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEE 803

Query: 491 LSNGTKGTRVPEQEEASTPMDPSRPL--PGSQLSLSSPGSTEDEDTGRP----LPPPHPQ 544
           L         P+ EE      P  P   P  + S  SP S E   + RP    L P   +
Sbjct: 804 LHLS------PQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEK 857

Query: 545 PPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGP 600
           PP  P+P       +P +     P  +EL     PG         E   S  GE P
Sbjct: 858 PPLSPRPE------KPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPP 907



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 124/587 (21%), Positives = 208/587 (35%), Gaps = 86/587 (14%)

Query: 6    ESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRVLE 65
            + +  L+++ +++ L  Q +L +   ++ +  Q++++      QL++QQ+  +     L+
Sbjct: 3892 QPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQ-----QQLQQQQQQQQ-----LQ 3941

Query: 66   NRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRL 125
             + +  L  +    Q+  +++QQ+F+    Q  Q+   L N+   L    +  +++V   
Sbjct: 3942 QQQQQQLQQQQQQLQQQQQQQQQQFQQ---QQQQQQMGLLNQSRTLLSPQQQQQQQV--- 3995

Query: 126  RVLGDRPKPRAKEGTSDPPS--PLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEK 183
              LG     +  +  S P +  P LL +      +         E    HQG  L     
Sbjct: 3996 -ALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTT 4054

Query: 184  PAGHRTSPVAKISPGATLPESR---APDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN 240
            P    T P  ++ P  +         P   PQ  S QL   + +     Q          
Sbjct: 4055 PESMATEP-GEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGG 4113

Query: 241  GTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHL 300
            G+   L + SS  + +    L+  S     +P +MT     L P+     +L RP+  + 
Sbjct: 4114 GSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNL--LGPQQP---MLERPMQNNT 4168

Query: 301  --QSPHSSPLAPAAAPSD-----PRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEG 353
              Q P   P+  +          P +  L+A+      +  +L      L+  Q  +L+ 
Sbjct: 4169 GPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQL----RHLSPQQQQQLQA 4224

Query: 354  ALHLLLAQQQLRARARAGSVRPRGQPTPGEML----PSL---------PVGSDSEGPENE 400
             L     QQ    R       P  Q +P + L    P L         P+     GP  +
Sbjct: 4225 LLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQ 4284

Query: 401  GTRAALAAAG-LSGGRHTQPAGPGRAQRTEAAATQDCALDKP---LDLSEWGRARGQDTP 456
            G     A  G LS G    P  P     +     +   L  P   L            TP
Sbjct: 4285 GPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTP 4344

Query: 457  KPAG-----QHGSLSPAAAHTA--------SPEPPTQSGPLTRSPQALS------NGTKG 497
            KP G       G +SPAAA  A         P  P  +   T+ P+  S      +   G
Sbjct: 4345 KPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNG 4404

Query: 498  TRVPEQEEASTPMDPSRPLP---GSQLSLSSPGSTEDEDTGRPLPPP 541
              VPE  + S   +P R  P   G+Q       S + E  G P+  P
Sbjct: 4405 QVVPEASQLSIKQEP-REEPCALGAQ-------SVKREANGEPIGAP 4443



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 112/487 (22%), Positives = 162/487 (33%), Gaps = 88/487 (18%)

Query: 179  RGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGP 238
            + ++  A HR + V K +      +++  D++ +     LH  I   +PG          
Sbjct: 2063 KAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRPALHLRIPP-QPG---------- 2111

Query: 239  ANGTPPPLPARS----SPPSPAYERGLSL--DSFLRASRPSAMTHEAP-----KLSPKVD 287
            A G+PPP  A +    SP +PA   GLS   D FL+    S    ++P     KL P+V 
Sbjct: 2112 ALGSPPPAAAPTIFIGSPTTPA---GLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVP 2168

Query: 288  RLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQ 347
                   P  L    P   P  P A P+ P         A+       +LG  S     Q
Sbjct: 2169 AQVPSQDPFGLAPAYP-LEPRFPTAPPTYPPYPSPTGAPAQP-----PMLGASSRPGAGQ 2222

Query: 348  DLRLEGALHLLLAQQQLRARARAGSVRPRGQP-TPGEML-PSLPVGSDSEGPENEGTRAA 405
                 G  H                  PR QP TP   L P  P   +   PE+ G    
Sbjct: 2223 P----GEFHT------------TPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGG 2266

Query: 406  LAAAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLSEWGRAR--GQDTPKPAGQHG 463
             A+  L       P   G +++      ++     P     +G       D+P      G
Sbjct: 2267 KASEPL-----LSPPPFGESRKALEVKKEELGASSP----SYGPPNLGFVDSPSSGTHLG 2317

Query: 464  SLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSL 523
             L           P     PLT     +   + G  +  QE    P     P P S   +
Sbjct: 2318 GLELKT-------PDVFKAPLTPRASQVEPQSPGLGLRPQEPP--PAQALAPSPPSHPDI 2368

Query: 524  SSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEV 583
              PGS  D     PL P   QPPP            P     L P S   D    P S V
Sbjct: 2369 FRPGSYTDPYAQPPLTPRP-QPPP------------PESCCALPPRSLPSD----PFSRV 2411

Query: 584  GLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGP 643
              S Q++ ++S +   P  +  +     P   R ++ +P  +   +P + R        P
Sbjct: 2412 PASPQSQ-SSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRP-QSRDPFAPLHKP 2469

Query: 644  GSPRDAE 650
              P+  E
Sbjct: 2470 PRPQPPE 2476



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 63/267 (23%), Positives = 82/267 (30%), Gaps = 69/267 (25%)

Query: 456  PKPAGQHGSLSPAAAHTASPEPPTQSGPLTRS------------PQALSNGTKGTRVPEQ 503
            P   G  GS  PAAA T     PT    L+ S            P   S G    ++P Q
Sbjct: 2107 PPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQ 2166

Query: 504  EEASTP-MDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQP------PP--------- 547
              A  P  DP    P   L    P       T  P  PP+P P      PP         
Sbjct: 2167 VPAQVPSQDPFGLAPAYPLEPRFP-------TAPPTYPPYPSPTGAPAQPPMLGASSRPG 2219

Query: 548  -------HPQPPDLDGHPEPSKAEVLRPESDELDE---TDTPGSEVGLSSQAEATTSTTG 597
                   H  PP    H   +    L+P    LD     ++PG   G +S+   +    G
Sbjct: 2220 AGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFG 2279

Query: 598  EGPECICTQEH-------GQGPPR-----KRKRASEPGDKASKKPSRGRRKLTATEG--- 642
            E  + +  ++          GPP           +  G    K P   +  LT       
Sbjct: 2280 ESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVE 2339

Query: 643  ---------PGSPRDAEDHSPSPNSSP 660
                     P  P  A+  +PSP S P
Sbjct: 2340 PQSPGLGLRPQEPPPAQALAPSPPSHP 2366



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 36/133 (27%), Positives = 49/133 (36%), Gaps = 16/133 (12%)

Query: 168  EAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRA-----PDMSPQRISNQLHGTI 222
            + E    G+GLR +E P     +P     P    P S       P ++P+          
Sbjct: 2337 QVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCC 2396

Query: 223  AVVRPGSQACPADRGPANG----------TPPPLPARSSPPSPAYERGLSLDSFLR-ASR 271
            A+      + P  R PA+           TP PL A +  PSP   R  S D + R  SR
Sbjct: 2397 ALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSR 2456

Query: 272  PSAMTHEAPKLSP 284
            P +    AP   P
Sbjct: 2457 PQSRDPFAPLHKP 2469



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 50/226 (22%), Positives = 77/226 (34%), Gaps = 23/226 (10%)

Query: 456  PKPAGQHGSLSPAAAHTASPEPPTQSGPLTRS---PQALSNGTKGTRVPEQEEASTPMDP 512
            P+P    GSL+     +     P +  P+T     P+      +G+   EQEE   P+ P
Sbjct: 1135 PEPGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAP 1194

Query: 513  SRPLPGSQLSLSSPGSTEDEDTGRPLPPPHP---QPPPH-----PQPPDLDGHPEPSKAE 564
            + P       ++   +    D     P   P    P P           +     P++ E
Sbjct: 1195 TPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDE 1254

Query: 565  -VLRPESDELDETD-----TPGSEV-GLSSQAEATTSTTGEGPECICTQEHGQGPPRKRK 617
              LR  +D L ETD       G+ + G  ++ E     +      I        P R+R 
Sbjct: 1255 GSLRLCTDSLPETDDSLLCDAGTAISGGKAEGEKGRRRSSPARSRIKQGRSSSFPGRRRP 1314

Query: 618  RASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSPWEE 663
            R    G +      RGR +L +T          D   SP+    EE
Sbjct: 1315 RGGAHGGR-----GRGRARLKSTASSIETLVVADIDSSPSKEEEEE 1355



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 66/252 (26%), Positives = 96/252 (38%), Gaps = 54/252 (21%)

Query: 131  RPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPP-GGHEEAEEDHQGVGLRGEEKPAGHRT 189
            RP P A   + D  S  L+   GG +A  ++ P  G    ++  Q +    +++ A   T
Sbjct: 2774 RPPPPATPSSMDVNSRQLV---GGSQAFYQRAPYPGSLPLQQQQQQLW---QQQQATAAT 2827

Query: 190  SPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPA---------- 239
            S   + +  A  P +  P++  Q + + L G    +    +  P   GPA          
Sbjct: 2828 S--MRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQ 2885

Query: 240  -----NGTP-----PPLPARSSPPS-------PAYERGLSLDSFLRASRPSAMTHEAPKL 282
                  GTP     PP   R  P S       P   RGL++ S L   +PSA    AP+L
Sbjct: 2886 KGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAV-SGLPPQKPSA--PPAPEL 2942

Query: 283  SPKV------------DRLCLLNR-PLSLHLQSPHSSPLAPAAAP-SDPRL-QDLKAREA 327
            +  +              L L+NR P S  L  P+   L     P  DP L  D  A +A
Sbjct: 2943 NNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNPLALEAGKLPCEDPELDDDFDAHKA 3002

Query: 328  EAWEEPTELLGL 339
               +E    LGL
Sbjct: 3003 LEDDEELAHLGL 3014


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 112/494 (22%), Positives = 151/494 (30%), Gaps = 87/494 (17%)

Query: 134  PRAKEGTSDPPSP---LLLPSPGGW--KAITEKPPGGHEEAEEDHQG------VGLR--- 179
            P A  G + PP P     L SPG     ++T       + A  D  G      +G R   
Sbjct: 601  PPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVI 660

Query: 180  --GEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRG 237
                + PA     P    SP    P   AP + P  +S       +   P +   P    
Sbjct: 661  PPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQES 720

Query: 238  PA---NGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNR 294
            P    + +PPP P  S  P P   +           +P  +  EAP  S   +       
Sbjct: 721  PVISKDQSPPPSPPPSYHPPPPPTK-----------KPEVVV-EAPSASETAEE------ 762

Query: 295  PLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGA 354
                    P   P  P   P  P  QDL   +    EE    +  P            G+
Sbjct: 763  --------PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGP------SGS 808

Query: 355  LHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSL-----------------PVG-SDSEG 396
              L+ +     + A A  ++P G P P    P+                  PVG S   G
Sbjct: 809  PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGG 868

Query: 397  PENEGTRAALA-----------AAGLSGGRHTQPAGPGRAQRTEAAATQDCALDKPLDLS 445
            P  E   A L            + G  GG  T   GP   Q+    A    A   P   S
Sbjct: 869  PPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSS 928

Query: 446  EWGRARGQDTPKPAGQHG--SLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQ 503
                A        A   G  S  P     A P PP    P + +    S G++  ++   
Sbjct: 929  GLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPP--QSPASTASFIFSKGSRKLQLERP 986

Query: 504  EEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKA 563
                T  D  R L     S+S     +        PPP  + P    PP     P   +A
Sbjct: 987  VSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPP--PASPSYPRA 1044

Query: 564  EVL-RPESDELDET 576
            E L  P ++ L  T
Sbjct: 1045 EPLTAPPTNGLPHT 1058



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 117/495 (23%), Positives = 167/495 (33%), Gaps = 86/495 (17%)

Query: 224 VVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLS 283
           + RP S A P   G A    P  PA S  P   Y         L    P A+      L 
Sbjct: 317 LTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATY---------LSKLIPHAV------LP 361

Query: 284 PKVDRLCLLNRPL------SLHLQSPHS-SPLAPAAAPSDPRLQDLK-AREAEAWEEPTE 335
           P VD + L    L      SLH  SP S   L   ++ S P+ +    +  ++ W     
Sbjct: 362 PTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQS 421

Query: 336 LLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSE 395
                + ++    L  +G      ++ Q  +   + SV P  Q   G   PS   GS +E
Sbjct: 422 S---DTIVSDGSTLSSKGG-----SEGQPESSTASNSVVPPPQGGSGRGSPS--GGSTAE 471

Query: 396 GPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEAAATQDCAL-DKPLDLSEWGRARGQ- 453
             +    R++   +G S         P   +RT +   +  A+ D PL L      + Q 
Sbjct: 472 ASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQP 531

Query: 454 DTPKPAGQHGSLSPAAAHTASPEP---------------PTQSGPLTRSPQALSNGTKGT 498
             P+P    GS    AA    P P               P +S   T SP +  +   GT
Sbjct: 532 QLPRPPTTGGSEGAGAA-PCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGT 590

Query: 499 -RVPEQEEASTPMDPSR---PLPGSQLSLSSPGSTEDED-------TGRPLP-------- 539
             +P +  A  P  P +   P P    SL SPG++           +  P P        
Sbjct: 591 PTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQI 650

Query: 540 ----------PPHPQ-PPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQ 588
                     PPHP+ P P   PP     P P+   +  P          P S    S Q
Sbjct: 651 LTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAV-----VPGPVSTTDASPQ 705

Query: 589 AEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRD 648
           +  T  TT    +        Q PP     +  P    +KKP       +A+E    P  
Sbjct: 706 SPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQ 765

Query: 649 AEDHSPSPNSSPWEE 663
             +  P P  +P E+
Sbjct: 766 DPNWPPPPPPAPEEQ 780



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/185 (25%), Positives = 71/185 (38%), Gaps = 11/185 (5%)

Query: 467 PAAAHTASPE-PPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSS 525
           P +   ASP+ PPT    LT   ++       +  P    +  P  P    P   +   S
Sbjct: 696 PVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPS 755

Query: 526 PGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKA--EVLRPESDELDETDTPGSEV 583
              T +E    P  PP P P P  Q   +   P P +A   V  PE          GS  
Sbjct: 756 ASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPE-----PAGPSGSPE 810

Query: 584 GLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGP 643
            +SS A +++S T    +   + +    PP     +S PG  A K P   +  +  ++G 
Sbjct: 811 LVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVA-KLPQ--KEPVGCSKGG 867

Query: 644 GSPRD 648
           G PR+
Sbjct: 868 GPPRE 872



 Score = 30.8 bits (68), Expect = 4.2
 Identities = 63/257 (24%), Positives = 86/257 (33%), Gaps = 53/257 (20%)

Query: 139  GTSDPPSPLLLPSP-----GGWKAITEKPPGGHEEA----EEDH----------QGVGLR 179
            G+ DPP     P+P     G    + +K P G  +      ED           Q V LR
Sbjct: 831  GSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLR 890

Query: 180  GEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRI-SNQLHGTI-------AVVRPGSQA 231
                P G  T  +   +P   L  + +   SP    S+ LH  +       A     S A
Sbjct: 891  SVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSA 950

Query: 232  CPADRGPANGTPPPLPARSS---------------PPSPAYERGL--SLDSFLRA---SR 271
             P     A   PP  PA ++               P SP  +  L  +L + LR+    R
Sbjct: 951  QPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQR 1010

Query: 272  PSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAE--- 328
            P     ++PK  P V R   +  P       P + PL        P  QD   RE     
Sbjct: 1011 PPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENG 1070

Query: 329  ---AWEEPTELLGLPSA 342
                   P E +GLP +
Sbjct: 1071 GVLQLVGPEEKMGLPGS 1087


>gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Homo
           sapiens]
          Length = 247

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 58/232 (25%), Positives = 89/232 (38%), Gaps = 27/232 (11%)

Query: 336 LLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSD-S 394
           LL L SA +  +D+  E +L L+  + + R R + G+   R  P PG+     P G + S
Sbjct: 10  LLALSSAESSSEDVSQEESLFLISGKPEGR-RPQGGNQPQRPPPPPGKPQGPPPQGGNQS 68

Query: 395 EGPENEGTRAALAAAGLSGGRHTQ--PAGPGRAQRTEAAATQDCALDKPLDLSEWGRARG 452
           +GP     +         GG  +Q  P  PG+ +R                    G  + 
Sbjct: 69  QGPPPPPGKPE--GRPPQGGNQSQGPPPHPGKPERPPPQ----------------GGNQS 110

Query: 453 QDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDP 512
           Q TP P G+     P   + +   PP    P    PQ  +        P + E   P + 
Sbjct: 111 QGTPPPPGKPERPPPQGGNQSHRPPPPPGKPERPPPQGGNQSQGPPPHPGKPEGPPPQEG 170

Query: 513 SRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQ-PPDLDGHPEPSKA 563
           ++    S+ + S PG  +         P  P PP  PQ PP   G+P+  +A
Sbjct: 171 NK----SRSARSPPGKPQGPPQQEGNKPQGPPPPGKPQGPPPAGGNPQQPQA 218



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 50/215 (23%), Positives = 71/215 (33%), Gaps = 25/215 (11%)

Query: 440 KPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTR 499
           KP      G  + Q  P P G+     P   + +   PP    P    PQ   N ++GT 
Sbjct: 56  KPQGPPPQGGNQSQGPPPPPGKPEGRPPQGGNQSQGPPPHPGKPERPPPQG-GNQSQGTP 114

Query: 500 VPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPE 559
            P       P  P RP P                + RP PPP     P PQ  +    P 
Sbjct: 115 PP-------PGKPERPPPQG-----------GNQSHRPPPPPGKPERPPPQGGNQSQGPP 156

Query: 560 PSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRA 619
           P   +   P   E +++ +  S  G   + +      G  P+        QGPP      
Sbjct: 157 PHPGKPEGPPPQEGNKSRSARSPPG---KPQGPPQQEGNKPQGPPPPGKPQGPPPAGGNP 213

Query: 620 SEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSP 654
            +P    + KP   +      +G   PR A+   P
Sbjct: 214 QQPQAPPAGKP---QGPPPPPQGGRPPRPAQGQQP 245



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 37/159 (23%), Positives = 49/159 (30%), Gaps = 22/159 (13%)

Query: 501 PEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQ------------PPPH 548
           PE         P RP P        P    ++  G P PP  P+            PPPH
Sbjct: 36  PEGRRPQGGNQPQRPPPPPGKPQGPPPQGGNQSQGPPPPPGKPEGRPPQGGNQSQGPPPH 95

Query: 549 PQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEH 608
           P  P+    P P      +       + + P  + G  S          E P      + 
Sbjct: 96  PGKPE---RPPPQGGNQSQGTPPPPGKPERPPPQGGNQSHRPPPPPGKPERPPPQGGNQ- 151

Query: 609 GQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPR 647
            QGPP        PG      P  G +  +A   PG P+
Sbjct: 152 SQGPPPH------PGKPEGPPPQEGNKSRSARSPPGKPQ 184



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 42/145 (28%), Positives = 53/145 (36%), Gaps = 22/145 (15%)

Query: 130 DRPKPRA---KEGTSDPPSPLLLPSP-GGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPA 185
           +RP P+     +GT  PP     P P GG ++    PP G  E      G   +G     
Sbjct: 100 ERPPPQGGNQSQGTPPPPGKPERPPPQGGNQSHRPPPPPGKPERPPPQGGNQSQGPPPHP 159

Query: 186 GHRTSPVAKI---SPGATLPESRAPDMSPQRISNQLHGTIAVVRPGS-----------QA 231
           G    P  +    S  A  P  + P   PQ+  N+  G     +P             QA
Sbjct: 160 GKPEGPPPQEGNKSRSARSPPGK-PQGPPQQEGNKPQGPPPPGKPQGPPPAGGNPQQPQA 218

Query: 232 CPADRGPANGTPPPLPARSSPPSPA 256
            PA  G   G PPP P    PP PA
Sbjct: 219 PPA--GKPQGPPPP-PQGGRPPRPA 240


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.128    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,309,307
Number of Sequences: 37866
Number of extensions: 2520507
Number of successful extensions: 30191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 381
Number of HSP's successfully gapped in prelim test: 2060
Number of HSP's that attempted gapping in prelim test: 15519
Number of HSP's gapped (non-prelim): 10803
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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